>seq_1
MDTGTVPEKKRVSSDRRKEKSRDAARSRRGKESEVFYELAQELPLPHSVSSSLDKASIMRLIISYLRMRKLLSTEEPMAEEETDLDAQLNGSYLKALEGF
LMVLSEDGDMIYLTENVNKCLGLAQFDLTGYSVFDFIHPCDQEELREMLVHKTGSKKTKEPNTARSFFLRMKCTLTSRGRTVNVKSAAWKVLHCSGHVRV
YDGCTEETPNGHKEPTVPYLVLICDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPDDLLNRSVYEYYHAMDSDHLTKTHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCIVCLNFVLSGIQDEKLVLSLEQMEDVKPVDQEEEEEQEEVKAVVEIRELDMSPAPKEVEEKGPELD
VIKLFTQAAEAQPFVSLYDQLKEEPEALNLLAPAAGDAIISLDFSCPDSEIQLVKEVPLYNDVMLPSTSDKLALPLSTLPPCEPLHVSTISSEAAKAESF
PSSTFTSLRSAEAGSLMDFCFPMDSEMKSDSKLDFVEKLFAIDTDPKNLFTTQAMEDLDLEMLAPYIPMDDDFQLRSLTPEEPLSCGPVKSLQSSPIHIT
QDIHSYPFSPVSAPGSRTASPALLRAPQTAPIIAMRTPQLDKEVSLRTLAAQNAQRKRKMGDIKEIIGQGTLPQEQVEQGKKLKASESGTTRTILLLPSD
MASRLLGCTSENTSSLFSLPHLTRDDCEVNAPLQGRQCLLQGEELLCALDHVNVI
>tr|H3B2A5|H3B2A5_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=HIF3A PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------CCIFSQLELIGHSVFDFVHPCDLEELKDMLCPRQGFSKKKKVNTERSFFIRMKSTLTSRGRTVNLKSASWKVLQCTGHMKT
YTSSEH-PEDGYPDLPMTYLIMTCEPIPHPSNIEVLLDSRTFLTRHNMDMKFTYCDERITELAGYHPDELIGQSAYEYFHALDSDPLSKCIHDVLSKGQA
VTGLYRFLTREGGYMWTQTQATVIYNSKNSQPESIVCLNFVVSGIEEKDVVFSLEQRESQLKPIVKILEK------------------------------
------RQSNADTKEDLFTKLKEDPEELTQLAPTPGDTIIPLDFSLDCKEPKVFVKPPDVSDAVFSATPEKFCSPELPIDPE-PRSVVSFQQQGPVAEVK
PGLTGLVFSDPEGW-EQGLYAIVSSGEEFNLEMENVQKLFATNKEAQDTDI-SQVRSLDLEMLAPYISMDDDFQLTVMEAKPLKEDDALPKSCGGSMTII
NQQEQLAD-EANGVKDTVETEVTTSSGTLSSPAKKRPLDLEDGLNSEALSVQNVKRRHCSGSEEPSASLGSLFDTEA-PAEKLWVWDEVFFNTFLYFSSA
LVQKLLFLSSEDS----VLPDITSYECGAASPLQSSRHLIQVEDLLRVLDQTT--
>tr|Q5IGQ2|Q5IGQ2_EPICO Hypoxia-inducible factor 1 alpha (Fragment) OS=Epinephelus coioides GN=HIF-1a PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVYDFIHPCDQEELREMLIHKIGSKKTKEPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCAGHIRV
YDNHVEDTSNGHKEPPVPYLVLICDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPDDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKMIFSLEQTEDVKPVKEEQMG-EEKVVVESSQPDMSPTLL-KEEEEKVPELD
VIRLFTQAVE-QPLVSLYDQLKEEPEALTLLAPAAGDAIISLDFSCPDSEIQLLKEVPLYNDVMVSSTSDKLALPLSPLPPSEPLDVTT-SSEVAKAESL
PSTTSTSHSSSETDSSLDFCFPMDSEMSSDFKLDLVEKLFAIDTEPKTPFSTQAMDDLDLEMLAPYIPMDDDFQLRSLTPDEPLSCGSVKSLQSSPVHVT
QDIHSYPSSPFSAPSSRTASPAPLSARHPVTMVTKRTPQLDKEVSLRTLAAQNAQRKRKLDDVKEMIEQQTLPKEQVEKGKKLKPSESGTTRTILLLPTD
VASRLLGSTAEGTSSLFTLPQLTRYDCEVN-------------------------
>tr|L7NCR4|L7NCR4_CYNSE HIF-alpha OS=Cynoglossus semilaevis PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVFDFTHPCDQEELREMLIHRSGSKKNKEQNTERSLFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YDNNTE-QTNGHKDPPVPYLILICDPIPHPSNIEAPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLLNRSVYEYYHALDSDHLNKTHHSLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQTEDVKPVKEEQEEEKAEVLSGLSDMPLTLLK--EEEDTKVPELD
VTKVFTQSVD---SSSLYDQLKGEPEALTLLAPAAGDTIISLDFSCPDSEIQLLNDAPLYNDVMLP--------------PSEPLNITV-GSDNSKSESY
PPAATTSNCSSETDSQLDFCFPMDS----DFKLDYVEKLFAIDTEPKTSFNSEIMADIDLEMLAPYIPMDDDFQLRCLTPEEPLTGVQVKSQHSSPLHIK
QDLTSYPSS----PASRTASPALPESLNLARLIGKRSPQSDKDVSLRTLVAQNTQRKRKLCDLKEIIEQGTLLEGQGEQGKKLKATELGSTTTILLLPSD
LASRLLGSTSDGTGSLFTLPHLTRYDCEVNAPLQGRQYLLQGEELLRALDHVI--
>tr|S5YDM3|S5YDM3_SEBSC Hypoxia inducible factor-1alpha OS=Sebastes schlegelii PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVFDFIHPCDQEELREMLVYKTGSKKAKEPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YDGHTEETSSGHKEPPVPYLVLICDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYSNKNSQPQCVVCVNFVLSGIQEEKLILSLEQIEDVKPVKEEEQH-EEEKVVVESSQPKD--------EEKGRELD
VIKLFTQTVE-KPLVSLYDQLKEEPEALTLLAPAAGDAIISLDFSCPDSEIQ-----PLYNDVMLPSTSEKLALPLSPLPPSEPLHVAT-SCKDAKAEGY
PSTTS---PSSEADSPMDFCFPMDSEMNSDFKLDLVEKLFAIDTEPKTPFITQAMEDLDLEMLAPYIPMDDDFQLRSLTPDEPLSCGPVKSLESSPVHVT
QDIHSFPSSPFSEPGSRTASPALLTAPQPATIVAKRTPQLHKEVSLRTLAAQNAQRKRKLGDIKDLIGQGTFPQEQVDQGKKLKASEAGTTRTVLLLPSD
LASRLLGSTSDGTSSLLNLPQLTRYDCEVNAPVKGRQYLLQGEELLRALDHVN--
>tr|Q30HV7|Q30HV7_ZOAVI Hypoxia inducible factor 1 alpha OS=Zoarces viviparus PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLEQFDLCGHSVFDYIHPCDTEELREMLVHKTGSKKAKEPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YDT--EETPNGHQEPPVPYLVLVCDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLLNRSVYEYYHALDSDHLTKTHHNLFTKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQIEDVKPVKEEEQQEEENDVVESSQPDISQFL--LEDEKKGPELD
VIKLFTQALE-KPLASLYDQLKAEPEALTLLAPAAGDAIISLDFSCPDAEILLLKEVPLYNDVMLPSTSDKLALPL-----SEPLRVAT-SSEDDKAKSY
WCTSS--SSSSEADSPLDLCYPMDSEMSSDSKLDLVEKLFAIDTEPKTPFITQAMEDLDLEMLAPYIPMDDDFQLRSLTPEESLSCGPVQSLQSSPVHVI
QDIHSYPSSPFSASGSHTASPAPLTAPHPATIVAKSTPQLDKEVSLRTLAAQNSQRKRKLGDIREIIGQETLPQEQVEQGKKLKASKSATTRTILLLPSD
LASRLLGSTSEGTDSLFTLPQLTRYDCEVNAPLQGRQSLLQGEELLCALDHVN--
>tr|A5H734|A5H734_PERFL Hypoxia-inducible factor 1 alpha OS=Perca fluviatilis GN=HIF-1a PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVFDFIHPCDQDELREMLVYKTGPKKAKESNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YDSHTEETPNGHKEPPVPYLVLICDPIQHLSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKQILSLEQIEDVKPVKEEEKA-VVESSQPDMSLTLPK------DEEKGPELD
VIKLFTQAVE-QPLASLYDQLKEEPEALTLLAPAAGDTIISLDFSCPDSEIQLLKEVPVYNDVMLPSTSDKLALPLYPLPPSEPLHVTT-SSEDAKAKSY
TSTTSTSHSSTEADSPLDFCFPMDSEMSSDFKLDLVEKLFAIDTEPKTPFNTQAMEDLDLEMLAPYIPMDDDFQLRSLSPEEPQSGGPVKSLESSPVHVT
QDIHSYPSSPFSAPGSRTASPAPLNAPNPATVVAKRTPQLDKEVSLRTLAAQNAQRKRKLGDLIEIIEQGTLPQEEVEQGKKLKASESGTTRTILLLPSD
MASRLLGSTSEVTGSLFTLPQLTRYDCEVNAPLQGRQFLLQGEELLRALDHVN--
>tr|A0A0B5KPC9|A0A0B5KPC9_9TELE Hypoxia-inducible factor 1 alpha B OS=Platypharodon extremus PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------SMGLTQFDLTGHSIFEFSHPCDHEELREMLVHRTGSKKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCAGHVRV
QERGEDSGDSGFKEPPLTYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGYEPDDLLNKSVYEYYHALDSDHLTKTHHNLFAKGQA
TTGQYRMLAKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDVVLSLQQTVTEPKAEEKENQTLEDEASEV---------------------D
ILKLFKLESLPMKNLDLYEKLKEDSEALTVLAPAAGDTIISLDFNN-DSDMQLLKEVPLYNDVMLPSGSEKLSISLSPLTPSDSTPVLTFSSASDLVPDS
PSTSGLGS--SGPNSPVDYCFQVDSDISSEFKLDLVEKMFAIDTEAKTPFSSQAMEDLDPEMLAPYIPMDDDFQLH-PSPLDPLPSGPHSSRAPSPLHLL
QEVCNAPVSPFSGT--RDVSPAR--IPQSSNQLNN------RELSPKMLAIQNAQRKRKLEEVTEAVGLSALLQSAIEPGKRAKVFLLGGNKTILILPSD
VASRLLCSSLENSS---GLPQLTRYDCEVNAPVQDRHHLLQGEDLLRALDQVN--
>tr|A5H737|A5H737_PLAFE Hypoxia-inducible factor 1 alpha OS=Platichthys flesus GN=HIF-1a PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVFDFTHPCDQEELREMLIHKTGSKKTKESNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YDTKTEETSNGLKEAPVPYLVLICDPVPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLLNRSVYEYYHAMDSDHLTKSHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATDIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQTEDEILVKKEQKRQEKEEKVVVESILPDMSTTVEEAAEKGPELD
VIKLFTQASK-QPLASLYDQLKEKPEALTLLAPAAGDTIISLDFSCPDSEMQLLKDAPLYNDVMLPSSSEKLALPLSPLPPSEPLNTRG-KSEESKAESY
PSTTITCQRSSEADSPMDYCFPMDSDMSSDFKLDLVEKLFAIDTEPKTPFNTQAMEDLDLEMLAPYIPMDDDFQLRSLTLDEPLTSGQVKSLKSSPVQVT
QQVDSYPSSPFSGVGSSTSSPAPLEVAHLATIIAKRTPQLDKEVSLRTLAAQNAQRKRKLGELKDMFGQGNLLEEQLVQGKKLKAAESGTTTTTFLLSSD
LASCLLGSTSDVTRP-LYLPQLTRYDCEVNAPLPGRQFLLQGEELLRALDHVN--
>tr|W5LPR6|W5LPR6_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLPQIDLSGQSVFDLTHPCDHEEIREMLVHRTGSSKIKEPNTERRFLLRMKCTLTSRGRNVNIRSASWKVLHCSGHIRA
PVRVCVQDDCEDRGVPASYLVLICNPIPHPASIEKPLDSRTFLSRHTLNMHFTYCDDRIKELLGYDPKDLLQQSVYEYYHALDSDSLTKTHHNLFAKGQA
CTGQYRMLVKTGGFVWMETQATVIYNSKNSQPQCVVCVNYVLSGVEDPELVLSLHQSGSMVVKQEKKEEEEEEKKEEEEE-----------------ERE
KQECFQK----IETAVLQDDLKEEPEVLNQLHFSSAACSASFTLKNRDIDAAVLKDVPLYNDVMLPSSSVLLPLSPLLPPPCASLPDTTFPLSSDTDTS-
STAGDTTTCSTQPTSP------LTSDHSYQCKMNSEEEIFSIETETKTLLDAQAVKDLDLEMLAPYIPMDDDYQLRVH---Q---SGCVSADPPPPAQPL
QSSSFYAFQCFTGFQDTNVSEL--E----TLQISSKTDSF--QVHGNMLALQQKLLKRKLE-TIQAVGLGSVVQVIPTAGKKVRRSALPETVTILLLPSD
VVAQLLAGPSEGRTLPVPLPQLTRYDCEVNVPVAGRQNLLQGEELLYALD-----
>tr|G4WI71|G4WI71_MYXAS Hypoxia-inducible factor 1a OS=Myxocyprinus asiaticus GN=HIF-1a PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------SMGLTQFDLTGHSIFEFSHPCDHEELREMLVHRMGSKKNKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRV
QERSEESGDCGFKEPPQAYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGHEPDDLLNKSVYEYYHALDSDHLTKTHHDLFAKGQA
TTGQYRMLAKKGGYVWVETQATVIYNPKNSQPQCIVCVNYVLCDIVEGNIVLSLQQTMTEPKAVVKESQEMEDEPSEV---------------------D
VLKLFRPEGLKESSSSLYEKLKEQPEALAGLAPAAGDTIISLDFNN-DSDVQLLKEVPLYNDVMLPSSSEKLPMTLSCLTTSESIPPLTFSSDSQRVPD-
PSTPGLGS--SGPNCPMDYCFQVDSDISSEFKLDLVEKLFAIDTEAKTPFTTQDMEDLDLEMLAPYIPMDDDFQLHIPSPLEQLPSGLNSSRAPSPLHLL
QKVCSAPVSHFSSS--REASPAR--TPQGGNQLNNRMPMGDRELSPKMQAIQNAQRKRKLEEVTEAVGLGALLQSAIESGKRAKILVLGGNKTILILPSD
VASRLLSSSLESSG---GLPQLTSYDCEVNAPVQDRHHLLQGNELLRALDQVN--
>tr|W5LJA8|W5LJA8_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFDLTGHSVFDFAHPCDHEEMREMLVHRTGSKKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRV
QESGEGSADSSFREPPITYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGHEPDDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQA
TTGQYRMLAKKGGYVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDMILSLEQTVTEPKAVEKEEKQKDKEEETE---------------------V
DMDSFKQEKLVESLESLYEKLK-EPEALTVLAPAAGDTIISLDFNS-ESEMQLLKEVPLYNDVMLPSTSEKLPLPLSPLAPSEPPPALDFPSTSHRSADA
PSTPSTGSSTSAPNSPIDYCFQVDSDIGSEFKLDLVEKLFAIDTEAKTPYSTQDMGDLDLEMLAPYIPMDDDFQLLIPSPLDPLPSGPHTSRVPSPLHML
QEVRSAPVSPFSGNRSREASPAR--TPQGSRTLTTGMSAVDRELSPKVLAIQNAQRKRKLEEVTQAVGLGALLQSAIEPGKRAKVLLLGGNKTILILPSD
VASRLLCSSFESSG---GLPRLTRYDCEVNAPVQDRHPLLQGEELLRALDQVN--
>tr|V9P247|V9P247_CLABA Hypoxia induced factor 1 alpha OS=Clarias batrachus GN=HIF-1 alpha PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFDLIGHSIFDFAHPCDLEEVREMMVHRPGSKKTKVQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRV
QEHSDGSGEGGFKEPSVTYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGHEPDDLLNRSVYEYYHALDSDHLNKTHHNLFAKGQA
TTGQYRMLAKKAGYVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEEDTVLSLQQTLPEKTEEKEEELQIEHEDSSV--------------------MD
MMKLFKKDHLVESPKSLYDTLKDEPEALTVLAPAPGDTFVSLDFDS-DSDLQVLKEVPLYNDVMLPSTSEKLPLPLSPLAPSDPSPALVISSTSRLTPDT
PPSSTSS---SEASSPSH-YFHVDSDI--NFKLDLVEKMFATDTESNSDFNTDEMGDLDLEMLAPYIPMDDDFQLHIPSSLNPLPSGPQTSHVPSPLHLL
QELSSIFGTPFN-----EASQTL--SPEPGIPLAKRMQVDDDEFASKVLTVQNGQRKRKLE-ITQAVGLDALLQSVGEPGKRAKVLLLGGNKTILILPSD
LASRLLSSSFESSG---GLPQLTRYDCEVNAPIQDRHPLLQGEELLRALDQVN--
>tr|W5UA58|W5UA58_ICTPU Hypoxia-inducible factor 1-alpha OS=Ictalurus punctatus GN=HIF1A PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFDLTGHSIFDFTHPCDHEEVREMLVHRTGSKKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRV
QEHSESSGGVGFKEPSITYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGYEPDELLNRSVYEYYHALDSDHLSKTHHNLFAKGQV
TTGQYRMLAKKAGYVWVETQATVIYNPKNSQPQCVVCVNYVLSGIVEEDMVLSLQQTVPEKTVEKEEELQVEQEDKSV--------------------MD
MMKLFKKDPLVESPKSLYEKLKDKPEALTVLAPAAGDTIISLDFDS-DSEIHVLKEVPLYNDVMLPSTSEKLPLPMSPLAPSDPSPDLVFSSTSHHVSDT
PSISASS---SEPSSPAD-YFHVDSDIGSEFKLDLVEKMFATDTEADTHFNTDEMCDLDLEMLAPYIPMDDDFQLHIPSPLDPLSSGPQTPHVPSPLHLL
QEVSSIFVTSFD-----EASGAH--TPQTGK-AAKRMQVEDQDLSTKSLN---VQRKRKLE-ITQAVGLDVLLQSAVEPGKRAKVLLLGGNKTILILPSD
VASRLLSSSFESRG---GLPQLTRYDCEVNAPIQDRQSLLQGEELLRALDQVN--
>tr|T1Q049|T1Q049_9ACTI Hypoxia-inducible factor 1 alpha subunit OS=Lepisosteus platostomus PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFDLTGHSVFDFTHPCDHEEMREMLTYRTGSLKKAKQNSERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIQV
YESSDGHNNCGYKEPPMTYLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYQPEDLLGRSVYEYYHALDSDHLTKTHHDLFAKGQA
TTGQYRMLAKKGGFVWVETQATVIYNTKNSQPQCIVCVNYVLSGVVQEDLVFSLGQTESV-LKPLE----SPDVEM------------------------
-PKIFTKAE-LESSNTLFEKLKEEPEALTLLAPAAGDTIISLDFTS-DSEIQPLEEVPLYNDVMLPSSSEKLPLSPLPPDPALNVEVVSFSFSIPRTQDS
PSGTSTRQNSPEPSSPGDYCFQVDSDIGSEFKLDLVEKLFAIDTEAKTPFATQTMDDLDLEMLAPYIPMDDDFQLRTLSPSETLSASAPVARAASPLHLV
QEVRNALNSPFSGSRSRTSSPAPSSTSSAT-SPSRRIPALEGALSPKMLAIQNAQRKRKLETGTQAVGIGTLLHEPAAIEKRAKVFAL-THKTILLLPTD
LASRLLECSFG-SD---GLPQLTRYDCEVNAPVQGRQHLLQGEELLRALDQVN--
>tr|A0A0P7YFP3|A0A0P7YFP3_9TELE Hypoxia-inducible factor 1 alpha subunit-like OS=Scleropages formosus GN=Z043_116106 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVFDFTHPCDHEELREMLVHRTGPSKKAKKNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCTGHVRV
YENIEGESHCGYKEPPVPYLVLICEPIPHPANIEVPLDSKTFLSRHTLDMKFSYCDERVTELMGYEPEDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQA
TTGQYRMLAKKGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSNIVEEKLVLSLEQTEKDVKGDVKEDVEDVNEDTEELKFSE----------PTGLEAD
MIKLFTKAED-ECADSLYDKLKEEPDGLTMLAPAAGDTIIHLDFSC-DPEQPLLKEVALYNDVMLPSTSVKPPLPPSEPDPPLSTKVRAFSMVRT--ADS
TPGPSAGRASPQPDSPLDFCFQVDSDIGSEFKLNLVEKLFAIDTEPKTPFT-QAMEDLDLEMLAPYIPMDDDFQLHVLSPAESLAST---RHAASPLHLL
QEVQSAPCSPFSGSCSRTSSPAPPDIPRCATPVGKRITGADVELSPKMLALHNAQRKRKLEGEAQALGLGALLEGTVNKGKRARVLGL-SHKTMLFLPSD
LASRLIGGSVD-GN---SLPQLTRYDCEVNAPVLDRQHLLQGEELLRALDQVN--
>tr|A5H729|A5H729_ACIGU Hypoxia-inducible factor 1 alpha OS=Acipenser gueldenstaedtii GN=HIF-1a PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFELTGHSLFDFAHPCDHEELREMLTHRTGSTKKGKHNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
CDPSKGENNCGYKERPMTSMVLICDPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYQPEDLLGRSVYEYYHALDSDHLTKTHHDLFAKGQA
ITGQYRMLAKKGGFVWVETQATVIYNTKNSQPQCIVCVNYVLSGVVGEDLVFSLGQTENV-LKPVE----SPDADI------------------------
-TKLLMQVD-EENTNSLFEKLKEEPEALTLLAPAAGDTIISLDFSKDNSEIKKLEEVPLYNDVMLPSSSEKMLMSPLPPDPVLNVEVVTISFTIPQTPDL
--LPSATQSLPEPSSPSDYCFKVETDFSGEFKMDLVEKLFAIDTEARTPFTTQVADDFDLEMLAPYIPMDDDFQLRTLSSIEPISASPPDMSIVSPLHMT
EEVKSAPNSPFSGKNSRTSSPIRKSLVPGTPLRSKRPTAFDEELSPK----MLAQRKRKLESGLKAVGIGTQLHQ---TLKRSKASVL-THKTILLLPTD
LASRLLACSFE-NS---GLPQLTRYDCEVNAPVQGKQTLLQGEDLIRALDQVS--
>tr|T1Q067|T1Q067_POLSE Hypoxia-inducible factor 1 alpha subunit OS=Polypterus senegalus PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFELTGHSVFDFTHPCDHEELREVLTHRAGAAKKGKVNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCLGHIRA
YESCE-ENDCGYKKPLVTSLVVICEPIPHPSNIEVPLDSKTFLSRHSLEMKFSYCDERITELMGYQPEDLLGRSVYEYYHAMDSDHLTKTHHNLFAKGQA
TTGQYRMLAKNGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSGVVEKDLIFSLSQTETLPVKAIE----DPELET------------------------
-VKVTGKTV-EGDGDSLFDKLKEEPEALTVLAPAAGDTIISLDFST-ESEMSSFEEVPLYNDVMLPSPNEKMLMSPVSSDPALNLEVAVLSFSIPQIHNS
SSLQSSTQSSPGPNSPVDYSFEVDSDISSEFKLDLVEKLFAIDTEAKTSFVSQAGDDLDLEMLAPYIPMDDDFQLRTMSPMESLPSNPLILRTVSPLHMI
HNVQSLSDSSFSIQTNEAASLLNNSAESIQTLLGKTICTLDEELSPR----TCAQRKRKLQIADKALEIGSVLPVSVGAWKRAKACAP-KHKTIILLPTD
LASRLLASSFE-SS---GLPQLTRYDCEVNAPLQGRQNLLQGEELLRALDQVN--
>tr|S7N5Y1|S7N5Y1_MYOBR Hypoxia-inducible factor 1-alpha OS=Myotis brandtii GN=D623_10027172 PE=4 SV=1
----SSDGSTRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDI--EDEMKAQMNCFYLKALDGF
VMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHV
YDTNGNQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNFVVSGIIQHDLIFSLQQTECVLKPVESSDMK------------------------------
MTQLFTKVE-SEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNETDDQQLEEVPLYNDVMLPSSNEKLQLAMSPLPASETPEVALLSFTMPQIQAS
PSDGSTRQSSPEPTSPSEYCFDVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDT-DLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSTSTASPSPTHVP
KETSSTTTSPYSDNRSRTASPNRAKGVHLSITLSQRTTVPEEELNPKILALQNAQRKRKIEHDGQAVGIAGQWLGRGPGMERVQAGLRGPMHEFQHRASN
LACRLLGQSMDES----GLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN--
>tr|Q6EHI4|Q6EHI4_DANRE Hypoxia inducible factor 1 alpha OS=Danio rerio GN=hif1ab PE=2 SV=1
----VTEK-KRVSSERRKEKSRDAARSRRGKESEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLLNSDEKE-EEENELESQLNGFYLKALEGF
LMVLSEDGDMVYLSENVSKSMGLTQFDLTGHSIFEFSHPCDHEELREMLVHRT-GSKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCAGHVRV
HEGSEASEDSGFKEPPVTYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERT-ELMGYEPDDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQA
TTGQYRMLAKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDVVLSLQQTVTEPKAVEK----------------------------------
---LFKPESLNCESSTLYNKLKEEPEALTVLAPAAGDAIISLDFNNS--DIQLLKEVPLYNDVMLPSSSEKLPLSLSPLTPSDSIP---FPFSSASDRPT
PST---------PNSPMDYGFPVEPDISSEFKLDLVEKLFAIDTEAKTPFSTQPMEDLDLEMLAPYIPMDDDFQLRPS-PLDPLP----AS-------LL
QEVCSAPVSPFSG--SRDASPVRSSS----------SQLNNREMSPKMLAFQ-IQRKRKLNEVT---GLGLLH-DAIDPGKRAKVLEVKGNKTILILPSD
VASRLLSSSLEG-----GLPQLTRYDCEVNAPVQDRHHLLQGEELLRALDQVN--
>tr|F7G7B7|F7G7B7_ORNAN Uncharacterized protein OS=Ornithorhynchus anatinus GN=HIF1A PE=4 SV=2
----------------------------------------------------------MRLTISYLRMRKLLDTGDLEA--EAEMEAQLNCFYLKALDGF
VMVLTEDGDMIFMSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTHRNGSVKGREQNTERSFFLRMKCTLTSRGRTVNIKSAAWKVLHCTGHIRV
YDACSNQAQCGYKKPPMTCLVLICEPILHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVQKDLIFSLGQTECVLKPVESPDMK------------------------------
MTQIFSKAD-PEDTSSLFDKLKKEPDALTLLAPAAGDTIIYLDFGNN-EEQQLLDEVPLYNDVMLPSSSEKLQLALSPLPATEPDKIVTLTFTVPQLQAS
PSDASTDQSSPEPSSPSEYCFNVDNDMASEFKLELVEKLFAEDTEAKNPFSAQDT-DLDLEMLAPYIPMDDDFQLRSFDQLSPIETGSANAVSPSPGHT-
ETTGAPA-SPYGGARSRTASPARAKGVHLSVTLSKRTTALDEELNPKMLALQNAQRKRKMEQDSQVVGIGSLLQQTSLSWKRVKGCKSSEQKTVVLLSSD
LASRLLGQSMDES----GLPQLTSYDCEVNAPIQGNRNLLQGEELLRALDQVN--
>tr|V8NR02|V8NR02_OPHHA Hypoxia-inducible factor 1-alpha OS=Ophiophagus hannah GN=HIF1A PE=4 SV=1
----GSCEKKRISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHHVSAHLDKASVMRLTISYLRMRKLLDADDLEA--EAEMETQLNCFYLKALDGF
VMVLSEDGDMIYTSENVNKCMGLTQFELTGHR----------------------SVKGKDQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
YENCNNQNVCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELIGYDHEELLGHSVYEYYHALDSDHLTKTHHDMFAKGQV
TTGQYRMLAKQGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVQGDLVFSLQQTERMLKPVDSPEMG------------------------------
MMKVLNKSD-VEDSSSLFEKLKKEPDALAYLAPAAGDTIIALDFDNDEPDEQPSDDVPLYNDVMLPSSSEKLQLAMSPLSASETAKVVALTFSSRRTQAT
PSDGSTSQSSPENSPPNDYCFSMDNEISSEFKLELVEKLFAIDPESKNPFSMQET-DLDLEMLAPYIPMDDDFQLRTFDQLSPLEGNTATTINPKVLPPA
PIISAPT-SPYAKNESRTSSPIRTKGTSLTVTFG-RSPEVNEDISPRIIALHNIQRKRKMEQDGQAVGIGTLLAQISLAWKRVKGCRSNAEKTVILLPSD
IASKLLGQSMDEK----GLPQLTSYDCEVNAPIQGNRNLLQGEELFRALDQIN--
>sp|Q9I8A9|HIF1A_XENLA Hypoxia-inducible factor 1-alpha OS=Xenopus laevis GN=hif1a PE=2 SV=1
----VVSEKKRISSERRKEKSRDAARCRRSNESEVFYELSHELPLPHNVSSHLDKASIMRLDHQLPAVEKVADAGDLDG--ETELDKQLNCFYLKALEGF
VLVLTEEGDMIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTFRNGPAKRKRTNHREKFLPSYEMYINQS-----WKNREYKVSHYRTHACI
YDNANNQNHCGYKKPPMTCMVVICEPIPHPSNIEFPLDSKTFLSRHSLDMKFSYCDERVTELVGYEPDELLGRSVYEYYHALDSDHLTKPNYNMFTKGQV
TTGQYRMLAKKGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSEVVEKDLILSLGQTASVLIPVESQEIK------------------------------
MPEIFTELNEENNSECLFDKLKQEPESLTVLAPDAGDEIIPLDFSSGDS-DKPYEDVPLYNDVMLHSTSNKLE-PITPLPAPEMPKVVIASIHHSTAIRQ
PFRYQFQSEPS-EPNTPEYCFDVDSEMASEFKLDLVEKLFAIDTEAKAPFYYPGN-DLDLEMLAPYIPMDDDFQLRTFDQLSSLECDSSST--QSPVHMK
ESTSAPV-SPYNGNRSRTSSPVRPKAVRPVP---KRCTILDEELNPKMICFTQCTEKRKMESDGQAIGIGTLFQTSSLQWKRVKGSDSEEQRTILLLSTD
MASQLLGQSFDGT----VLPQLTGYDCEVNAPVHGTRNLLQGEELLRALDQAN--
>tr|A0JMU1|A0JMU1_XENLA HIF-1a protein OS=Xenopus laevis GN=HIF-1a PE=2 SV=1
----VVSEKKRISSERRKEKSRDAARCRRSKESEVFYELSHELPLPHNVSSHLDKASIMRLAISYLRLRRLLDAGDLDG--ETDLDKQLNCFYLKALEGF
VLVLTEEGDMIYLSENVNKCMGLTQFEFTGHSVFDFTHPCDHEELREMLTFRNGPAKGKEQITERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHMRV
YDNANNQKHCGYKKPPMKCMVVICEPIPHPSNIEFPLDSKTFLSRHSLDMKFSYCDERVTELVGYDPDELLGRSVYEYYHALDSDHLTKAHHNMFTKGQV
TTGQYRMLAKKGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSEVVEKDLILSLGQTACVLIPAESQEMK------------------------------
MPEIFTDLSEENNDECLFDKLKQEPESLTALAPDAGDDIIPLDFSSGDS-DKPYEDVPLYNDVMLHSTSNKLE-PVTPLPASEMLKVVILAFTIPQPSGS
PSDIGSSQSST-PSSPPEYCFNVDGEIASEFKLDLVEKLFAIDTEVKAPFTTQET-DLDLEMLAPYIPMDDDFQLRTFDQLSSLECDSSSA--QSPVHMK
ESTSAPA-SPYNGNRSRTSSPVRPKAVRPVQ---KRCAVLDEELNPKMIALHNV-RKRKMESDGQAIGIGSLFQTSSLLWKRVKGSDSDEQRTMLLLSTD
MSSQLIRQSLDGT----GLPQLTGYDCEVNAPVHGNRNLLQGEDLLRALDQAN--
>tr|B3FMV7|B3FMV7_RANTE Hypoxia-inducible factor 1 alpha OS=Rana temporaria GN=HIF-1a PE=2 SV=1
----VTD---KKSSERRKEKSRDAARCRRSKESEVFYELSHQLPLPHNVSSHLDKASIMRLTISYLRIRRLLDAGDMDG--ESEMEKQLNCFYLKALEGF
VLVLTEEGDMIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTFRNGPSKGKEQITERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHMRV
YDGCNSQNHCGYKKPPMTCMVLICEPIPHPSNIEFPLDSKTFLSRHSLDMKFSYCDERVTELAGYEPDELLGQSVYDYYHALDSDHLTKAHHDMFTKGQV
TTGQYRMLAKKGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSDIVEKELILSLGQTESTLVSSEPAESK------------------------------
MPQFFTKLADEEDANVLYEQLKKAPEFLNVLAPDAGDEIIPLDFSSSDS-ESQYDDAPLYNDVMLHSTSKPPE-LVSPLPVPEKPKVVILAFTIPQLSSS
PSEISSNQSST-PGTPAEYCFDEDINVAPEFKMDLVEKLFAMDTEAKAPFSTQET-DLDLEMLAPYIPMDDDFQLRSFDQLSSMETDSASN-VHPPTPNK
EALSAPA-SPYNGNRSRTSSPVRTKAARTSP---KRPAVLDDELSPKMIALHNV-RKRKIESDGQAVGLGTIFQTSPLLWKCVKVSDSDEQRTILLLSTD
MASRLLGQSLDGT----GLPQLTGYDCEVNAPIQGNRNLLQGEDLLKALDQAN--
>tr|T1Q069|T1Q069_PROAN Hypoxia-inducible factor 1 alpha subunit OS=Protopterus annectens PE=2 SV=1
----TICDKKRISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHNISSHLDKASIMRLVISYLRMRALLSTSNIED---DESDKQLNSFYLKALDGF
VMVLTEDGDMIYLSENVNRCIGLTQFELTGHSVFDFMHPCDHEELREMLTHRIGPVKGKGQSTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCSGHIRV
YESGSDQTHCGFKEPPLTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYDPEDLLNHSVYEYYHALDSDNLTKTHHDLFTKGQV
TTGQYRMLAKEGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVEKGLIFSVEQTKSLMKSVPALDAD------------------------------
KTKHLS----TENPGHLFEKLKEEPEALTLLAPAPGDTIIPLDFNNTDTDAQSLDSVALYDDVMLSSDEKV--MDKSPLPASEAAKVVTLSFTVAQTQNS
PSDPSASQNST-PSSPSDYCFRVESDIDNEFKLDLVEKLFAVDTEAKNPFSAQVE-GLDLEMLAPYISMDDDYQLRSFDQLPPLESDSVSPSPQSPIRIR
EISSAPT-SPYSASRSRTSSPVRTKGPRSPVLQ-HRAASSDQELSPKMLALQNVQRKRKMENEGTAAGIGALFQCNSSTRKRVKGYESSEQMTLLLSSTD
LASRLLGQSVESS----KLPQLTSYDCEVNAPIQGNKNLLQGEDLLKALDQVN--
>tr|B6ZGN4|B6ZGN4_CRAGI Hypoxia-inducible factor 1 alpha OS=Crassostrea gigas GN=HIF-1a PE=2 SV=1
----MSSNTKRRNSEKRKEKSRDAARCRRGRETEIFSELAEQIPQYSGSNGQLDKASIMRLAISYLKISQIMETQRNN---RHAPCEEFDSLYSKALDGF
VVILSNEGDLIYISESVSKYLGIQQVDLVGQSIYEFVHPCDHEDITDIFHSNGRDKKKKSEEFHHTFFVRMKCTLTNKGKNVNLKSATYKVIKFSGKLVK
DKIKK---ECG-GEGNAPYLLLIGEPIPHPSNIEIPLDQMTFLSRHNMDMKFTYCDDRVKDLLGYNCSDLMNKSLFDYHHAMDSEVIDQAYKNLIAKGQV
MTRQYRFLAKTGGHVWMITQGTVIYNSRTQKPQCIVCVHYVLSGIENPSLILSTAQQVFSQQVPMLPLEV------------------------------
KL-FYFPP-----GVKMPSMKMDETVDLTHLAPTSGDTCVPLIGDDC--QFS--------PDQ--------------PMPALKEE----DMFSARICSIT
------------PISPMDYTTPLTP-----SVVDAMDKFFSNVETQR----NQATADLDMDMRAPYIPMNKDFSLLPTSSD--------RS---------
--YQDPPKEPRMS--------------S------------SIEQPPDTF---NLQLKRPLDMNS---PSK-----YQEPTKKH------AKPYFPAM--G
HR-----DSLSGP----TMPQ---TQE----VIETPDLLLQNPDLLAALELFL--
>tr|F4ZC48|F4ZC48_CRAVI Hypoxia-inducible factor 1 alpha OS=Crassostrea virginica GN=HIF-1a PE=2 SV=1
----MSSTTKRRNSEKRKEKSRDAARCRRGRETEIFSELAEQIPQYSGSHGQLDKASIMRLAISHLKISKIMETQRNN---RHAPCEEFDPLYSRALDGF
VLILSNEGDLIFISESVSKYLGIQQVDLVGQSIYEFVHPCDHEDITEIFHSNGRDKKKSSD-CYHTFFVRMKCTLTNKGKNVNLKSATYKVIKFSGKLVK
DEVKR---EAG-GDGSAPYLLLIGEPIPHPSNIEVPLDRMTFLSRHNMDMKFTYCDDRVKDLLGYNCSDLINKSLFDYHHATDSEVIDHSYRNLVAKGQV
MTGQYRFLAKTGGHVWMITQGTVIYNSRTQKPQCIVCVHYVLSGIENPSLILSTSQQSYSQQVPMLPLEV------------------------------
KL-FYFPP-----GTKIPSMKIDESVDLTHLAPTSGDTCVPLIGDKC--QFS---------DQ--------------PMPALKEE----DMFSTRVCSTT
------------PISPMDYTTPLTP-----SVVDAMDKFFSAVETPR----NQATADLDMDMRAPYIPMNKDFSLLPTSSD--------RS---------
--YQDPPKEPRMS--------------S------------SIEQPPDTF---NLQLKRPLDMNS---PVK-----YQEVPKKH------AEAYYPLL--G
K------GSHSGA----ALPQ---DEE----VMETPDLLLQNPDLLAALELFL--
>tr|H3BFX9|H3BFX9_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=HIF1A PE=4 SV=1
----IVTDKKRVSSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLLGAGEFEA--EADLDKQLNSCYLKALDGF
VMVLTEDGDIIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTHRNSPVKSKEQHTERNFFLRMKCTLTSRGRTVNIKSATWKVLQCTGHIQV
YETCKGKTHCGYQEPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELIGYQPEELLGRSVYVLYYALDSDHLTKTHHDLFTKGQA
TSGQYRMLAKEGGYVWVETQATVIYNTKNSQPQCVVCVNYVLSGVVEKELVFSIGQAKKTVESVESPDAK------------------------------
ITQLFSKIKPAEDSNSLFDQLKEEPEALTLLAPAAGDTIISLDFSKSDSEVQQFDEVPLYNDVMLPSSSENLQLEMSPLPASETTEVVTLSFSVPQTQST
PSEHHTSQSTP-PKSPPDYCFEVDDDIVSEFKLDLVEKLFAIDTEPKSFFSTQEAEELDLEMLAPYIPMDDDFQLRSFDQLSPLQSGSESN-TVKSIQPS
HINSAPA-SPYSGNRSRTASPVRTSGLCSPVTLN-RTITLNKELNPLTILLHNVQRKRKLENEAQAVGIETLF-D--AGCKRTKGIQSSQQKTLILLSTD
LASRLLERSED-N----RLPQLTRYDCEVNAPIQDSRNLLQGEELLRALDQIN--
>tr|K7FUF4|K7FUF4_PELSI Uncharacterized protein OS=Pelodiscus sinensis GN=HIF1A PE=4 SV=1
----VTPLRYRISSDRRKEKSRDAARCRRSKESEVFYELAHQLPLPHTVSAHLDKASIMRLTISYLRMRKLLDSSDLET--EAKMEKEMNCFYLKALDGF
VMVLSEDGDMIYMSENVNKCMGLTQFELTGHSVFDFTHPCDHEELKEMLTHRNGLVKGKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRV
YDTCNNQTHCGYKKPPMTCLVLICVPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFAKGQV
TTGQYRMLAKHGGYVWVETQATVIYSTKNSQPQCIVCVNYVLSEIVQEELFFSLGQTERVLKPVESVDMN------------------------------
MTKIFSKAD-LEDSNSLFEKLKKEPDALTLLAPAPGDTIVSLDFDSNESDEQQFDEVPLYNDVMLPSSSEKLQLAISPLPASETTKVVSLAFSSRPRQSS
PSDTSTNQSSP-PHSPNDYCFDVDNDMANEFKLELVEKLFAIDTEAKNPFSTQET-DLDLEMLAPYIPMDDDFQLRSFDQPPPLESGCAVTVSQSPVLIN
EIDSTPA-SPYGGNRSRTASPIRAKGTYLTVTLSNRSNPVDEELNPKMLALHNSQRKRKMEYDGQAVGIGSLFQQAS-LWKRVKGCKSNGQKTIILLSTD
IASKLLGQSMDET----GLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN--
>tr|U3JLA1|U3JLA1_FICAL Uncharacterized protein OS=Ficedula albicollis GN=HIF1A PE=4 SV=1
-----CKDSKKISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHTVSAHLDKASIMRLTISYLRMRKLLDAGELET--EAKMEKELNCFYLKALDGF
VMVLSEDGDMIYMSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTHRNGPVKGKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
YDTCGNQTHCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKQGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVQKDLIFSLGQTECMLKPVDSPDMK------------------------------
MTKIFSKDD-LDDTNSLFEKLKQEPDALTVLAPAAGDTIISLDFSSNESDEQQCDEVPLYNDVMLPSSSEKLQMAMSPLPASETTKVVSLSFTMPQVQTS
PSDASTSQSSP-PSSPNDYCFDVDNDMASEFKLELVEKLFAIDTEAKNPFSTQET-DLDLEMLAPYIPMDDDFQLRSFDQLSPLESS-SGTVPSSPARAP
EPGGAPA-SPYGGSSSPTASPIRAKGASLTVTLNKRSTALDEELNPKMLALHNAQRKRKMEHDGQAVGIGSLFQQASLAWKRVKGCKTNEQKTIILLSTD
IASKLLGQSMDES----GLPQLTSYDCEVNAPIQGNRNLLQGEELLRALDQVN--
>tr|G1KSA4|G1KSA4_ANOCA Uncharacterized protein (Fragment) OS=Anolis carolinensis GN=HIF1A PE=4 SV=1
----GRRTKGRISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHHVSSHLDKASIMRLTISYLRMRKLLDAGDLEA--EAEMETQLNCFYLKALDGF
VMVLSEDGDMIYMSENVNKCMGLTQFDLTGHSVFDFTHPCDHEELREMLTHRNGPVKGKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
YDNCNNQTVCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELIGYDPEELLGRSIYEYYHALDSDHLTKTHHDMFAKGQV
TTGQYRMLAKQGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGVVQGDLIFSLQQTECMLKPVESPEMG------------------------------
VIKILDQTE-LEDSNSLFEKLKKEPDALTYLAPAAGDTIIALDFDSDETDEQQFDEVPLYNDVMLPSSSEKLQLAMSPLPASEATKVVSLSFSIRQTQAT
PSDGSTSQSSPESSTPSDYCFDVDNEMASEFKLELVEKLFAIDPESKKPFSMQET-DLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSAAA------HPL
ETNSVPA-SPYTDNSSRTASPVRTKGTSLTVTLGSRSTAANEDINPKIIALHNIQRKRKMEQDGQAVGIGTLLAQVSLAWKRVKGCKPNAEKTVILLPSD
IASKLLGQSMDEK----GLPQLTSYDCEVNAPIQGNRNLLQGEELLKALDQVN--
>tr|F6RGY6|F6RGY6_MONDO Uncharacterized protein OS=Monodelphis domestica GN=HIF1A PE=4 SV=1
----GTNDKKKISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRMRKLLDAGDLEA--EAEMEAQLNCFYLKALDGF
VMVLTEDGDMIYMSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLIHRNGPVKGKEQNTERSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIRV
YDTCNNQSQCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIVQHDLIFSLGQTECMLKPVEAVDRK------------------------------
ITELLTNVE-TEDTSSLFEKLKKEPDALTLLAPAAGDTIISLDFDNNETDE-QQLEVPLYNDVMLPSSSEKLQLAMSPLPATETTKVALLSFTMPQIQAS
PSDASTRQSSP-PSSSSEYCFDVDNDMANEFKLELVEKLFAEDTEAKNPFSTQDT-DLDLEMLAPYIPMDDDFQLRSFDQLSPLENTSTSNASPYSVYIN
ETASAPA-SPYDGNRSRTASPDRAKGVHLSVTLSYGTTALDEELNPKILALQNSQRKRKMEHEGQAVGIGSLHQQISLSWKRVKGCKSNEQKTVILIPSD
LVSRLLGPSMDES----GLPQLTSYDCEVNVPIQGNRNLLQGEELQRALDQVN--
>tr|S9XYU6|S9XYU6_9CETA Hypoxia-inducible factor 1 alpha isoform 7-like protein OS=Camelus ferus GN=CB1_000839028 PE=4 SV=1
---------MGISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDI--EDEMKAQMNCFYLKALDGF
VMVLTDDGDMIYISDNVNKYMGLTQ-----------------------------------------------------------------VLHCTGHIHV
YDTNSNQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMK------------------------------
MTQLFTKVE-TEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNEADDQQLEEVPLYNDVMLPSSNEKLQLAMSPLPSSETPKVALLSFTMPQIQAS
PSDGSTRQSSP-PNSPSEYCFDVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDT-DLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSTSTAFPSPPHPK
ETACATT-SAYSDTGSRTSSPNRAKGVHLSVA------------------------------------------L--LTPKTVN----------------
----IHTDTLRPN----QLESIYTYSCHNAAQTPDLLVLFNF------FYSLV--
>tr|G3SJ03|G3SJ03_GORGO Uncharacterized protein (Fragment) OS=Gorilla gorilla gorilla GN=HIF1A PE=4 SV=1
----IDKSPCRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDI--EDEMKAQMNCFYLKALDGF
VMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHV
YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMK------------------------------
MTQLFTKVE-SEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNETDDQQLEEVPLYNDVMLPSPNEKLQLAMSPLPTAETPKVALLSFTMPQIQPS
PSDGSTRQSSPE------YKFDSNTYLNH--KLHLCVCL---------NFSTLK----LLQELLPNLDLSTCFRLKNWSRLFPIAHSKLFDYRGWDIQSE
QLFSCTCQSQSVTTHQVTLKPKKTKLLCLSACIS---------IVP-TISLHCYIFSVKLSFDGWGKSVGTLLQQTSLSWKRVKGCKSSEQKTIILIPSD
LACRLLGQSMDES----GLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN--
>tr|V9KA26|V9KA26_CALMI Hypoxia-inducible factor 1 alpha OS=Callorhinchus milii PE=2 SV=1
----VNPEKKRVSSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHSVSSHLDKASIMRLTISYLRMRKLLSPRDVEV--EPDREKQLNSFYLKALEGF
VLVLTQDGDMIYMSENVNKYMGLTQFELIGHSIFDFTHPCDHEEMREMLSHRQGLQKGKDQITERSFFLRMKCTLTSRGRTVNIKSSSWKVLHCTGHIQV
HEGSDEQTPCGYKEPPMTCLALVCEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYQPDELLGRSVYEYYHAMDSDHLTKTHHDLFSKGQA
TTCQYRMLSKEGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGVVEKGVVFSLDQTESVPVTDESPDTI------------------------------
ETTGKSYNS-PTESNDLFNKLKEEPEALTQLAPAAGDTIISLDFSPS--DS-EMQHFPLYNDVMLPSSTEQ-K--LSPLPPSDPTKAITLSFTIPQMKNS
PSCPSTNQSSP-PSSPSEYCYNVDTDMSNVFKLDIVEKLFAVDPEAKNPFSVQDVDGLDLEMLAPYIPMDDDFQLRSLDQLSPLTDIQASNSSPSPLHMD
EVSSTPG-SPYSKPTSRTASPVRTGLLRPVKP--KRGGNLQEEVDAKLLSLHNLQRKRKIENAAQAAGIGLLSQNAPQIWKRAKRSDTTKEKTLASLPTD
TVSRLLMHSSETR----KLPTLTSYDCEVNAPIQNNRNLLQGEDVLRALDQVN--
>tr|B7SCS8|B7SCS8_9CHON Hypoxia-inducible factor 1 alpha OS=Hemiscyllium ocellatum GN=HIF-1a PE=2 SV=1
----GTEKKCSGSSERRKEKSRDAARFRRGKESEVFYELARELPLPHSVTSHLDKASIMRLTISYLRMRKLLNAGDMEV--EADLEEQLNSFYLKALEGF
VMVLTQDGDMIYMSENVNKCMGLTQFELIGHSVFDFTHPCDHEEMREMLSHRQGLLKGKDQNTERNFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
YKSSNEQTHCGYKEPPMTCLILICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYQAEELLGRSVYEFYHALDSDHLTKTHHDLFTKGQA
TTGQYRMLGKEGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSGLVEKEVILSLDQIECVPVE--KPEEP------------------------------
---SKHPVS-STETNNLFDKLKEEPEALTQLAPAAGDTVVSLDFNPS--EMQQFNEVPLYNDVMLPSSTNQ-KMALSPLPPSDAKKSIIFSFAIPQMNSS
SSCPCSSQNSP-PSSPSDYCFNVDTDISNEFKLDIVEKLFAIDPEAKHPFSVQDIDNLDLEMLAPYIPMDDDFQLRSLDQLSPFSDCQTADPLSTP--TI
KRDNGPS-SSQNKKSNRTTSPVRTGLLRPVKA--KRGEAPKEELSPQLLILHNSPRKRKLENAAQAVGIGLLFQSTSQTWKRAKGLEDSEQKTLVLVPTD
IVSRLLTHSAESS----SLPTLTNYDCEVNAPIQGNRTLLQGEEVLRALDQIN--
>tr|B4Y034|B4Y034_MUSCA Hypoxia-inducible factor 1 alpha OS=Mustelus canis GN=HIF-1a PE=2 SV=1
----GSEKKCGGSSERRKEKSRDAARCRRSKESEVFYELAYELPLPHSITSHLDKASIMRLTISYLRMRKLLDAGNAEI--EADVEKHLNSFYLKALEGF
VMVLTQDGDMIYMSENVNKCVGLTQFELIGHSVFDFTHPCDHEEMREMLSHRQGPLKGKDQNTERNFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
YKSNNEQTHCGYKEPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYQPEELLGRSVYEFYHAMDSDHLTKTHHDLFTKGQA
TTGQYRMLGKEGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSGLVEKEVVLSLDQTECAPVSDEKSEEP------------------------------
---SKSPVS-STKADNLFDKLKEEPEALTQLAPAAGDTVVSLDFSPS--EMQPFKEVPLYNDVMLPSSTNQ-KMALSPLPPTDSKKSIIFSFTIPQMNSS
SSCPCTSQNSP-PSSPSDYCFNVDADISNEFKLDIVEKLFAIDPEAKHPFSVQDINDLDLEMLAPYIPMDDDFQLRSLDQTSPLADSQTTGSLSSL--TN
QIVSTPG-SPQNEKSSRTASPVRTELIHPVES--ESREAPNEDLSPMVLLLHNSPRKRKLENAAQAVGIGLLFQSTSQTWKRAKEFDANEQKTLVLLPTD
IVTRLLTHSAEGS----SLPTLTNYDCEVNAPIQGNRTLLQGEEVLRALDQVN--
>tr|G5C5I4|G5C5I4_HETGA Hypoxia-inducible factor 1 alpha OS=Heterocephalus glaber GN=GW7_21080 PE=4 SV=1
----VYTLESRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLNTGDLDF--EDEMKAQMNCFYLKALDGF
VMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMKEMLTHRNGPVKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHV
YDTNNNQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMK------------------------------
ITQLFTKVE-SEDTSSLFDKLKKEPDALTLLAPAAGDIIISLDFSSNETDDQQLEEVPLYNDVMFPSSSEKLQLAMSPLPASESPKVALLSFTMPQIQAS
PSDGSTRQSSPEPNSPSDYCFDVDSDMVNVFKLELVEKLFAEDTEAKNPFSTQDN-DLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASTVSPSPTHLK
ETAHATTSSPYSNTPSRTTSPNRAKGAHVPVTLSQRNTIPEEELNPKIQALQNAQRKRKMEHDGQAVGI-TLLQQTSLSWKRVKGCKSSEQKTIILIPSD
LACRLLGQSMDES----GLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN--
>tr|G4WI69|G4WI69_MYXAS Hypoxia-inducible factor 2a OS=Myxocyprinus asiaticus GN=HIF-2a PE=2 SV=1
----AEKEKKRCCSERRKEKSRDAARCRRSKETEVFYELAHQLPLPQSISSHLDKASIMRLAISFLHTRKLLTSDCVTATETTEVDRLMDTWYVKSLGGF
ITVVTSDGDMIFLSENINKFMGLAQVELTGHSIFDFTHPCDHEEIRENLSFKTG--KVKDLNTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQLKV
YNGCPAHVLCGFKEPPLTCVVMMCEPIPHPSNIDTPLDSKTFLSRHSMDMKFTYCDDRVTELMGYNPEDLLGRSAYEFYHALDSDSVTKSHQNLCTKGQA
VSGQYRMLAKHGGYVWVETQGTVIYNSRNSQPQCIVCVNYVLSDIEEKSIIFSLDQTESLLKPQHLS---------------------------------
SF-FSPSKGL--DSEELYNKLKEEPEDLTQLAPTPGDTFISLNFGR-P-QYEEH---PGYSEVS-------S-IAPSVSHTIHDGH---STFSVPQGSSA
------------PSSPEDYYNTVDT----DLKVELTEKLLSLDTQTKTSYNQTDLSDLDLETLAPYIPMDGDFQLNIC-QEEPSS-IGGNSVPYSNGPQI
PPYHDPASTPLSSMGGRQNLQWPPG--KSVPANQQR--QCYRETRPVQLALASFKRS-------TQMAM---A-EQQTMWKRLR---HE--------LSG
IASRLIRPSFETY----SLPELTRYDCEVNVPMQGNLHLLQGCDLLKALDQSS--
>tr|W5KA07|W5KA07_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
----AEKDKRRSTSERRKEKSRDAARCRRSKETEVFYELAHQLPLPHSVRSHLDKASIMRLAISFLRTRKLLTSGCRPS--ETEMDRQMDSLYVKSLEGF
VSVVTSDGDIIFLSENINKFMGLTQVELTGHSIFDFTHPCDHDEIRENLSLKTG--KGKELSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLKV
YNSCPPRVLCGFKEPPLTCVVMMCEPIPHPSNIDTPLDSKTFLSRHSMDMKFTYCDDRVTELMGYSPEDLLGHSVYEFYHALDSESCTKSHQNLCTKGQA
VSGQYRMLAKHGGYVWVETQGTVIYNSRNSQPQCIVCVNYVLSDIEEKNKILSINQTESSFKTHHMS---------------------------------
SF-FSQAGAAVATGGALFTKLKEEPEDLTHLAPTPGDAIIALDFAP----YKDY---PTCSKI-------------SATHSTDEGQ---ATFSVPQAPSA
------------PSSPGDYYSSVDN----DLKVELTEKLFALDTQTKNSCSQTDLSDLDLETLAPYIPMDGDFQLNIC-PEDSPC-AAGNNMVYG-SPQL
PPYHDPACTPLSSMGGRQNLQWPPG--NAMPVNRHRPGEAYRDMSPARLAIASMKRS-------SQMTM---G-EPEMIWKRMR---NENYREYSMLTEG
VASRLLGPSFETY----CLPELTRYDCEVNVPLQGNLHLLQGSDLLWALDQAT--
>tr|Q696W2|Q696W2_CTEID Hypoxia-inducible factor 2 alpha OS=Ctenopharyngodon idella GN=hif-2alpha PE=2 SV=1
----AEKEKKRCSSERRKEKSRDAARCRRSKETEVFYELAHQLPIPHSISSHLDKASIMRLAISFLRTRKLLTSGCVAATETTDVDRLMDSWYLKPLGGF
ITVVTSDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKAG--KGKELNTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLKV
CNGCPARVLCGFKEPPLTCVVMMCEPIPHPSNIDTPLDSKAFLSRHSMDMKFTYCDDRVTELMGYSPEDLLGRSAYDFYHALDSDNVTKSHQNLCTKGQA
VSGQYRMLAKNGGYVWVETQGTVIYNSRNSQPQCIVCVNYVLSDVEEKSMIFSMDQTESLFKPHNLN---------------------------------
SF-FSPSKRSLGQSEALFTKLKEEPEDLTQLAPTPGDTIISLDFGQ-P-QYEEH---PMYSKVS-------S-VAPPVSHSIHDGH---ATFSVPQAPSA
------------PSSPGDYYTPVDS----DLKVELTEKLFSLDTQTKASCNQNDLSDLDLETLAPYIPMDGDFQLNIC-QEEPAS-IGGNSIPCSRGPQM
PPYHDPASTPLSSMGGRQNLQWPPG--KTMPANRQR--QNYRDMSPARLALTGFKRS-------TQMTM---G-EQQTLWKRLR---NENYREFSMQMDG
IASRLIGPSFETY----SLPELTRYDCEVNVPLQGNLHLLQGSDLLRALDQST--
>tr|F8W2W5|F8W2W5_DANRE Uncharacterized protein OS=Danio rerio GN=epas1a PE=4 SV=1
----AEREKKRHPSERRKEKSRDAARCRRSKETEVFYELAHQLPLPHSISSHLDKASIMRLAISFLRTRKLFSSGHTVQQMRSQNLGQMDNLYLKSLEGF
VIVVTSDGDMIFLSENVSKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSIKSVYGRGKEMSTSRDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLQV
CSSRPPQILCGFSEPPLTCITMLCAPIPHPSNVDTPLDSKTFMSRHSMDMKFIYCDERVSSLIGYRPEELLGRSVYEFCHALDSENMTKSHQNLCNKGQV
VSGQYRMLAKNGGYVWVETQATVIYNNRNSQPQCIICINYILSSVEEQSVIFSLDQTEALFKPYHTYDMG------------------------------
EI-FSQNT--SIPQNNLFTTLKEEPEELAQLAPMPGDAIIALDFER-A-EFEEA---TFFSKSS-------KLPAVGPSWVVDTPP---SSFTVPQVPKT
PC----------PNSPVDCCGSGEW----DLKVELTEKLFAPESGATNPTDSLNLSDLDLETLAPYIPMDGDFQLHIC-LEEPVP--GLSD---------
--------------KQRQSLHWPPVGCGFNV---QRPV--QKGMSLGQRALLNFKRKRQSEFPLSDIPK---Q--TDGMRKRMKPMNDDSSRQYNMMHTG
MISQLLAPSFDSY----CLPELTRYDCEVNMPLQGNLHLLQGSDLLRALDQST--
>tr|A0A0B5KPD4|A0A0B5KPD4_9TELE Hypoxia-inducible factor 2 alpha A OS=Schizopygopsis pylzovi PE=2 SV=1
----AEKEKKRHPSERRKEKSRDAARYRRSKETEVFYELAQQLPVPHSVSSHLDKASIMRLAISYLRTRKLFNSGRTVLQTQSQDDSQMDSLFMKSLEGF
VAVVTSDGDMIFLSENVSKCMGLTQVELTGHSIFDFTHPCDHEEIRENLSVKSLYGRGRDMSTGRDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQLQV
CSSRPPQVLCGFSEPPLTCVTMLCAPIPHPSNVDTPLDSKTFMSRHSMDMKFIYCDERVSSLIGYSPEELLGRSVYEFCHALDSESMTKSHQNLCNKGQV
VSGQYRMLARHGGYVWMETQATVIYNNRNSQPQCIICINYVLSSVEEQSVIFSLDQTESLFKPYHMCNMG------------------------------
EL-FSQGGASSVAEDILFTKLKEEPEELAQLAPMPGDAIIALDFDR-P-DFEEP---TFFSKSA-------QLPVVVPSWVVNTPP---STFTRAQVPKT
PC----------PSSPVDYSGSGEC----DLKVELTEKLFNSESVATNLTDSLDPSDLDLETLAPYIPMDGDFELHIC-PEEPVS--GLSD--TCPDTHV
QPYQTAPNVPFSSREGRQILQWPPIRCDFTS---HRPV--QKLMSVGQIALVNFKRKRSSEFSSTDIPK------ADGMQKRMKTTNVDSNRQYHMMHTG
MISQLLGPSFDSY----CLPELTRYDCEVNVPLQGNLHLLQGSDLLRALDQTT--
>tr|H2NLG0|H2NLG0_PONAB Uncharacterized protein OS=Pongo abelii GN=LOC100939432 PE=4 SV=2
----GANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDI--EDEMKAQMNCFYLKALDGF
VMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGPVKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHV
YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSIVIFHTITSSIEDENCNFKVENILMYK------------------------------
KVEEVSIVD-CKDNSDLCENPCGRAQWLTPVIPALWEAEAGGSLEVRETDDQQLEEVPLYNDVMLPSPNEKLQLAMSPLPTAETPKVALLSFTMPQIQPS
PSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDT-DLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASTASPSPTHIH
KETTSATSSPYRDTQSRTASPNRAKGVHLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGQAVGII------------------------------
-------------------------------------------------------
>tr|T1Q070|T1Q070_ACISI Hypoxia-inducible factor 2 alpha subunit OS=Acipenser sinensis PE=2 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELSHQLPLPHNVSSHLDKASIMRLAISFLRTRKLVSSIWPDNES--ESDKQMDGLYLKALEGF
IAVVTQDGDMIFLSENINKIMGLTQVELTGHSIFDFTHPCDHDEMRENLSLRNGFGKNKDLNTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQVKV
YNSCPPHTLCGFKEPPLTCVVMMCEPIPHPSNIDMPLDSKTFLSRHSMDMKFTYCDERVTELMGYWPEELLGRSVYEFYHALDSDRMTKSHQNLCTKGQA
VSSQYRMLAKHGGYVWVETQGTVIYNTRNSHPQCIVCVNFVLSDIEENSVIFSLDQTESLLKPHVLSMNS------------------------------
FF--NS--GVPAASEQLFTRLKEEPEELAQLAPTPGDTIISLDFG-----GPPFEEAPLYK-AVM--------PPPNKPWAVEERNPE-AAFSVPQGSRL
STSSCSTP-----SSPGDYYSSLDN----DLKVELTEKLFAMDTAAKAQCTTLELNDLDLETLAPYIPMDGDFQLNIC-QEEPPLSNSDTSLP----TLV
PFYHTPTSTPLSSMGGRQNVQWPPKWSC----HSQ-E-QGKD-VTPARTAVAHYKRKRQAEYRDQQLLME-----PEMMWKRMKALKA-NYREFNML-MG
MASRLLGPSFETY----SLPELTRYDCEVNVPVLGNLNLLQGGDLLRALDQAS--
>tr|V9KF35|V9KF35_CALMI Hypoxia-inducible factor 2 alpha OS=Callorhinchus milii PE=2 SV=1
----ADKEKKRSNSERRKEKSRDAARCRRSKETEVFYELAHQLPLPHNVSSHLDKASIMRLTISFLRTRKLLTSGLEN---ETDSERQMDSLYLKALEGF
ITVVTQDGDIIFLSENVNKHMGIAQVELTGHSIFDFTHPCDHEEIRENLTLKNGFGKNKDLNTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGHIKM
YNTCLPHTLCGYKEPPLTCLIMMCEPIQHPSNIDVPLDSKTFLSRHSMDMKFTYCDERVTTLMGYHPEELLGRSVYEFYHALDSDHMTKSHQNLCTKGQA
VTGQYRMLAKHGGYVWVETQGTVIYNSRNSQPQCIVCVNYVLSDVEEKNVMFSMDQTESLFKPCLPLRN-------------------------------
VN-GRYINGASVDSELLFSKLKEEPEELAQLAPTAGDAIISLDFGINQ-QLEKT---SLYNKGA-------M-PPPNKQWPVEITK---HSFVVPRVTAT
PS----------PSSPGDYYSSMDN----DLKIELTEKLFSMDTQAKNQCSQVELSDLDLETLAPYIPMDGDFQLSIC-CEEPPT-NT-NS-----HIPL
PQYHGSVNTPVSSMGGRPSIQWPPKWRTGHPAQRVK--QHGKDISPALTAFTNLKRKRQLEFGELSAEC---P-YAQFLWKRMKAIKCE--------LTG
MASRLLGSSFVSY----SLPELTRYDCEVNAPVVGNSTLLQGRELLRALDQAT--
>tr|T1Q050|T1Q050_POLSE Hypoxia-inducible factor 2 alpha subunit OS=Polypterus senegalus PE=2 SV=1
----ADKEKKRNSSERRKEKSRDAARCRRSKETEVLYELAHQLPLPHSISSHIDKASIMRLTISFLRTRKLLSSTIPSS--DSGSDKYIDSLYLKTLDGF
IAVVTQDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSPKHGFSKNREASSVRDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLKM
YNSHHPHTLCGFKEPPLNCVIMICEPIPHPINIDIPLDSKTYLSRHSMDMKFTYCDERITELMGYSPEELLGRSIYDFYHALDSDSLTKSHHNLCTKGQA
VSGQYRMLAKHGGYVWIETQGTVIYNSRNSQPQCIVCINYVLSEIEEDSIIFSMDQTESLFKPHVIS---------------------------------
MS-NFFSSGMPTSSELLFTKLKEEPEELAQLAPTPGDAIISLDFGA-Q-PFDEP---PIFNQKA-------I-HPPKKPWPQVENI---GAFIVPQGACT
PS----------PSSPGDYYSTMDS----ELKVELTEKLFAMDTESKSQCKTPELSDLDLETLAPYIPMDGDFQLNIC-QEEHPL-KPPNSLSYA-GSVA
PPYLTPSSTPLSSMGGRQNIQWPPKWRIHQPHHQQR--HQNKEMIAVQQDFISFKRKRHLEFSQQEEAL---G-N--ATWKKLKAVKAEGYREFTVLLEG
MATRLLGPTFDSY----SLPELTRYDCEVNVPLHGHLNLLQGSDLLRALDQGS--
>tr|W5NHS9|W5NHS9_LEPOC Uncharacterized protein OS=Lepisosteus oculatus PE=4 SV=1
----AEKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHQLPLPHNVSSHLDKASIMRLTISFLRTRKLLSSTWPDNVS--EADRQMDSLYLKALDGF
IAVVTQDGDMIFLSENINKFLGLTQVELTGHSIFDFTHPCDHDEIRENLSFKPGFGKNKDLNTERDFFMRMKCTVTSRGRTVNLKSASWKVLHCTGHLKV
YNSCPPHVLCGFKEPPLTCVIMMCVPIPHPSNIDMPLDSKTFLSRHSMDMKFTYCDDRVTELMGYCPEDLLGRSVYEFYHALDSDSMTKSHQNLCTKGQA
ISGQYRMLAKHGGYVWVESQGTVIYNSRNSQPQCIVCVNYVLSEIEESLVLFSMDQTESLFKPHVLSMGS------------------------------
FF--SN--GAAASSELLFTKLKEEPEDLAQLAPTPGDAIIALDFG-----GPQYEEAQMYSKAAM--------APPSKTWPVEAQQAE-AAFSVTQPPSS
TTSSCSTP-----SSPGDYYSPMDN----ELKVELTERLFALDTDPKSPYTTSEVSDLDLETLAPYIPMDGDFQLNIC-QDEVPLPSS-NNLP----TVM
PPYHTPSSTPLSSMGGRQNLQWPPKRSN----YRQ-Q-PQKD-MSPSRIALVSFKRKRLLELAEQPLPGE-----SEMIWKRMRNLKT-SYREYSMP-EG
MVSWLLGPSFESY----SLPELTRYDCEVNIPLQGNLNLLQGSDLLRALDQAT--
>tr|D7NII2|D7NII2_9CHON Hypoxia-inducible factor 2 alpha (Fragment) OS=Hemiscyllium ocellatum GN=HIF-2a PE=2 SV=1
----------------------------------------------LIVSTHLDKASIMRLTISFLRTRKLLSSGGPE-T-ETETEKQMDALYLKALEGF
IMMATQDGDIIFLSENISKYMGLTQVELTGHSIFDFTHPCDHEEIRENLTIKN-FGKHRDMNTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGHIKI
YNACQAHTLCGYKEPPLTCLIMMCEPIQHPSNIDIPLDSKTFLSRHSMDMKFTYCDERIAALMGYCPEELLGRSVYEFYHALDSDHMIKSHQNLCTKGQS
VTGQYRMLAKHGGYVWVETQGTVIYNSRNSQPQCIVCVNYVLSEIEEKNVVFSMDQTESLFKPCQAMKNM------------------------------
NG--KHICGGPMDGNLLFSKLKEEPEELAQLAPTPGDSIILLDFSV--NGNQQFEEAPLYNKA-I--------IPQNKLWPMEATKGPARQFTVPQVPNC
SSTSC-------PSSPGDYYSSLDN----DLKIELIEKLFALDTEAKKQCSTAELSDLDLETLAPYIPMDGDFQLSIC-HDEQPPSNTPNNLSGN--RSL
AAYHAPGCTPASLMGGRPNVQWPPKWRS----GHQ-Q-HGKDITNE--MIFRNLKRKRQLDFG-QPSADS----ESQMLWKRMKSIKSE-----------
-------------------------------------------------------
>tr|T1Q053|T1Q053_PROAN Hypoxia-inducible factor 2 alpha subunit (Fragment) OS=Protopterus annectens PE=2 SV=1
----ADKEKKRTSSERRKEKSRDAARCRRSKETEVFYELARQLPLPHSISTHLDKASIMRLTISFLRTRKLLSSAWP--K-ETESDCQMDGLYLKALEGF
ITVVTQDGDMIFLSENVSKYMGLTQVELTGHSIFDFTHPCDHEEIKENLCLKN-YGKNREMNSERDFFMRMKCTVTSRGRTVNLKSATWKVLHCTGHIQT
HGSCQQHTLCGFKDPLLAYLIIVCAPIQHPSNIDIPLDSKTFLSRHSMDMKFTYCDDRITELMGYHSEELLGRSVYEFYHALDSENMTKTHQNLCTKGQV
ISGQYRMLAKHGGYVWIETHGTVIYNSRNSQPQCIICINYVLSTIEENNTVFSVDQTESVFKPHLMTMNS------------------------------
IF--SR--SVLAQGDLLYRKLKEEPDDLEQLAPTPGDAVVSLDF-----GTQRFDDSSVYKKSIM--------PLTNTSWTPEAKKAE-PAFSLPQVPSC
SSSSCSTP-----SSPGDYYGPLES----DLKTELVEKLFAMDTESKNQCNTADFNELDLETLAPYIPMDGDFQLNIC-QEEHPVSYPQSGLAD---KGL
PPYQAPASTPLSSQGGRANVQWPPKWRS-GTQQSQ-Q-RGKD-VTPAMIAISSLKRKRQLQYI-QEISGD----ACHAIWK-------------------
-------------------------------------------------------
>tr|G3WFA1|G3WFA1_SARHA Uncharacterized protein OS=Sarcophilus harrisii GN=EPAS1 PE=4 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHNVSSQLDKASIMRLAISFLRTHKLLSSVCTENETEVEADQQMDNLYLKALEGF
IAVVTQDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGFGKSKDVSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKV
YNSCAPHSLCGYKEPLLTCLIIMCEPIQHPSTMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSESMTKSHQNLCTKGQV
ISGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIICVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNS------------------------------
IF--DT--KVPVKSNFLFTKLKEEPEELAQLAPTAGDAIISLDFG-----NQSFEESSTYNKA-L--------LTPSQPWPGDMKNSE--SFTVPQMASS
SN----------PSSPGDYYSSLDE----NLKMEMIEKLFAMDTESKNQCNTTDFNELDLETLAPYIPMDGDFQLSIC-QEERPPLNAQTSIFGS--KTL
PPCYGPASTPLSSMGGRSNTQWPPKWT-R-SPPNK-P-RGPDKMNPAMIALSKLKMKRQLEYE-QDMSGG----LPHLMWKRMKSLKG-HYQDYNPPKSG
MTSRLLGPSFEPY----LLPELTRYDCEVNVPVPGSSTLLQGSELLRALDQAT--
>tr|Q6GP97|Q6GP97_XENLA MGC80589 protein OS=Xenopus laevis GN=epas1 PE=2 SV=1
----AEKEKKRNSSERRKEKSRDAARCRRSKETEVFYELAHQLPLPQSISSHLDKASIMRLAISFLRTHKLLSSVCADRNIETDSEKQMDNLYLKALEGF
VAVVTQDGDMIFMSENVNKYLGLTQVELTGHSIFDFTHPCDHDEIRENLSMKTGSGKNRDANTEHDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGHVKA
YNSYHPHSLCGFKEPILSCLIMMCQPIQHPSNIDIPLDSKTFLSRHSMDMKFTYCDDRIIELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCAKGQV
VTGHYRMLAKHGGYLWVETQGTVIYNTRNSQPQCIVCVNYVLSEIEKNDVVFSMDQTESLFKPHFLTMNS------------------------------
IF--SS--S--VKSDFLFTKLKEEPEELAQLAPTPGDEIVSLDF-----GSQTFDEPASFNSSVQ--------TSPSKPWPLEVKNVD-PSFKAPQVANS
SNSTCSTP-----SSPEAYYSSLDE----DLKIELIEKLFAMDTEAKNQCNTNDFNDLDLETLAPYIPMDGDFQLNIC-QEESTINTPQSSVLEK-MAPL
TPYHTGATPPLSSMGGRPNVQWPPKWRS-SLPHNQ-Q-RGKD-LHPTEIPFCSVKRKRPLDYG-PPVDVG----LTLLMWKRIKALKS-SYHDYNMQRKG
LTSCLIGPSFESY----LLPELTRYDCEVNVPVVGNSTLLHGRDLLRALDQTT--
>tr|H3BEE1|H3BEE1_LATCH Uncharacterized protein OS=Latimeria chalumnae PE=4 SV=1
----VFVTPHRVCSEKRREKSRDAARCRRGKESEMFFHLAQQLPAPYSITSRLDKASIMRLTISYLRLRHLLSALTLKGEKEASGFPEETDLVFTALKGF
LMVVSQTGEMIFLSDNATGFLGPTQVELVGQNLFDFIHPCDQEEIRNVLSLKH---IRKKQSKDCDFFVRMKCTLTNQGRMVNLKSASWKVLHCTGQVKL
TPSHQ--------GAPQGCLVLLCEPIPFPSELETPVSKEMFLTRHSLDMKFTYCDKRVKDLIGYQESELLGRSVYEYYHVLDADRIRKSHHNLFAKGQT
STGQYRMLCKHGGYVWVQTDASVIYSDRNSQPRCVICINYVLSRSLETEIIVSLEQTERLFKSWDVLHTD------------------------------
S--------MLPESRLPFRKLRESPEELVQLSPSPGDVVKSFDFTAQA---TCPVAMVIYP-----P-------PSSQATPLLTPN----------TPRT
PST---------PNTRRQHYNPRKN----TFEVELIEKLFASDLDSQTRCSPGDFNDLDLETLAPYIPMDGDFELTIC-QEHPSPS---PSPSCC-----
---YGEARTCMHYGGIQQRILWPP---AS-----RRPPFHFTGRSVSALIFLSLKRKQELGFPPEECT-------EEILWKRKRLLSGFNFPFFFPL-AD
LTRYWL----TSS----VLPVLNSLDCEVNAPVHGRSRLLQGNELLRVLDQAA--
>tr|S4RYA8|S4RYA8_PETMA Uncharacterized protein (Fragment) OS=Petromyzon marinus PE=4 SV=1
----TEEKNNNATSERRKEKSRNAARCRRSKETEVFCELARELPLPQSVSASLDKASVMRFAISFLRMRKLLASDGSTE--HIDSMGDIDPAFLKVLEGF
FLVMNHDGDIVYLSDNVSKYLGTTHVDLVGQSIFDFTHPCDHEEIKEILSCKQGSAKNKETPTEIDFLMRMKCTITNRGRTVNLKSASWKVLNCSGHQKV
CGSSSTESSHGFKDPAQTYLVLICQPIPHPAELEAPLDSHTFLSRHTLDMKFSYCDDRVVDLIGYCPEELLGKSVYEYYHALDSDNITKSHHSLFSKGQA
KTGQYRMLAKHGGYVWVQTQASVIYNSRSAQPQSVVCIHYVLSGVEENTTIFSLEQTERLFKLQDTAQGA------------------------------
EGDEACPREAPQDSGRLYAMLKEEPDELAQLAPTPGDTIVPLQFNS-T-VFIYT-----YKNYNSAP----LC--------DDTT----SPFTAHQMSST
PS----------PGSPEDVYASC-N----DLRVELVEKLFAKSTD--QNSYTDDYSTVDLEMVAPYIPMDGDFQLCLS-LQEQMAANPLQS-VTKPAIND
SSFYGATDQGLA-AAGKCGSSWPYGRHFASVAAQQRPCKRSPE---------NLKRKWHLDGGITHMV------DSHPPWKRSKVWDDTPPLQQQYLPTG
LASCLLGRSFEGV----HLPTLTSYECEVNAPVQDIQNLLQGKDLLMALDQAT--
>tr|A0A0F7ZE51|A0A0F7ZE51_CROAD Endothelial PAS domain-containing protein 1-like OS=Crotalus adamanteus PE=2 SV=1
----AEKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHNISSHLDKASIMRLAISFLRTHKLLSSVCSHNEREIETDQQLDNLYLKALEGF
ITVITQDGDMIFLSENISKYMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGCGKNKEMSLERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQIKV
YNTCPPHALCGFKEPLLSCLILMCEPIQHPSNTDIPLDSKTFLSRHSMDMKFTYCDDRITELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCGKGQV
VTGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIICVNYVLSEIENNEIVFSMDQTESLFKPHMMSMNS------------------------------
IY--DH--GIPVKSDFLFTKLKEEPEELAQLAPTPGDAIISLDF-----GTQKFEEIPTYNKA-A--------MTPNTQWVTEGKNTE-PSFTLPQVASS
SNSSCSTP-----SSPGDYYTSLDE----DLKIEMIEKLFAMDTDAKNQCSSSDFNELDLETLAPYIPMDGDFQLSIC-QEERPLCSVQNSAFGSQSSFL
LPYYAQANTPLSSMGGRPNTQWPPKWRI--SAPNK-Q-RGID-INPARIALASLKLKRQLNYE-QHLNGT----DTHLMLKRMKILTS-PYQDFSVSRSG
IASRLLGPSFEPY----LLPELTRYDCEVNVPVMGSSTLLQGGDLLQALDQAT--
>tr|Q8QGM4|Q8QGM4_FUNHE Hypoxia-inducible factor 2 alpha OS=Fundulus heteroclitus PE=2 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHQLPMPHSVSAHLDKASIMRLAISFLRTRKLIATSSGSGSCNGAEDELMDNMYLKSLEGF
ITVVTSDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKSSFRKGKDVSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLKM
YDGCPSRVLCGYKEPPLTCAVLMCEPIQHPSNIEAPLDSRTFLSRHNMDMKFTYCDDKVTELIGYSPEDLMGRSIYEFYHALDSDSVTKSHHNLCTKGQA
VSGQYRMLAKNGGYVWVETQGTVIYNSRNSQPQCIVCINYVLSDVEEKSVIFSLEQTEALFKTPHMS---------------------------------
RF-FTAEGAGRTPGDSLFTTFKEEPDELAQLAPTPGDTIISLDFGH-P-ELEKSQHPAPFTPVSSAS----MHPSGPPSWTSESRK---GAFTVQQNPSA
------------PSSPGDYYSSVES----DQRLELTEKLFALETENDSDAHTEDLSDLDLETLAPYIPMDGDFQLNII-PESEPL-MS-NS-SCMMGPQS
PHFRGPASTPLSS------MQWPPKACEQNIS--QR--QAYKDVNPARV---SIKRS-------NQMAL---G--TDVVWKKMRGDG--SYTEYNPLTEG
IASRLLGPTFEPS----CLPELTRYDCEVNVPLQGSLHLLQGCDLLQALDQCI--
>tr|S4R4L9|S4R4L9_PETMA Uncharacterized protein OS=Petromyzon marinus PE=4 SV=1
----TLSLPSRVNSERRKEKSRDAARCRRSNETEVFYELANELPLPHSVTSHLDKASIMRLAISYLRMRKLLHNGAVV----EDCQEEMDSLFGKALEGF
VMALTEEGDMVFLSDGVNKCVGLAQVDLMGHSIFDFVHPCDQEEVREMLVYRQ----VKAPPSEVCQXMRMKCTLTNRGRTVNLKSASWKVLHCSGHMKL
YEGSAASAGGKRARXQVLLLMKSRTPPARRANQQSALDFQTFQNPHVKFMVHACCTEEILMLFENLPEELHFSATPTTGHTAHAHPLVCSSHAVFTKGQA
VTGQYRILAKGGGYAWVETQATVIYSSRNSQPQCVVCVNYVLSGIVENDTIFSLEQTERLFKPNKAAVGQ------------------------------
V-----SEGTDEDMALLYTQLKNEPDELAQLAPTAGDVVVPLDFGTG---LASFDDVPLYNDVMMAASPEPMPSPATPTKAFAELP---GPVGDPSLTHG
PSSPS-------PNSPSDYYS----AVGGDLKVDLIEKLFAVDSEIKEVSRVKSLDDMDLEMLAPYIPMDGDYQLCLSLPDGPLP----ES-------LP
PAAPQPP-----------------SRH---------MPAEDAEIYLLSIIYNANNKN--VTLYS-----------SVGPVKKMPKHTISISPYAVVQSTD
LVSRLLGPTLEDI----TLPMLNSYDCEVNAPVQDSRTLLQGEELLKALDQLS--
>tr|M3ZS27|M3ZS27_XIPMA Uncharacterized protein OS=Xiphophorus maculatus PE=4 SV=1
----------------------------------------------------------MRLAISFLRTRKLLTTS----HCDGEEDRLMDNLYLKSLEGF
VTVVTSDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKSSFRKGKDQSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQLKM
YDGCPSRVLCSYKEPPLTCAILMCEPIPHPSNIDVPLDSRTFLSRHSMDMKFTYCDEKVTELMGYTPEDLLGRSVYEFYHALDSDSVTKSHHNLCSKGQA
VSGQYRMLAKNGGYIWVETQGTVIYNSRNSQPQCIVCINYVLSDVEEKSVIFSLEQTEALFKSPNMS---------------------------------
SF-FTTEGASMNSGASLYKKFKTEPEDLAQLAPTPGDTIISLDFDR-T-EFEESQQPAPFTPVSSSP----MPPPGPACWTIESQH---RAFTVQQKPSA
------------PSSPGDYYSSVES----DLRVELTEKLFALETENDSTAHTEDLSDLDLETLAPYIPMDGDFQLNII-PESEPQ-LS-NS-SYMMPPRN
PPFRGLAGTPLSS------MQWPPKACEQNTS--QR--QAYKDLDPARV---SIKRS-------NQMAL---G--TDAIWKKMRGDG--SNKEYNVM-SG
IASRLLVPSFEPS----CLPQLTRYDCEVNVPLQGNLHLLQGCDLLRALDQST--
>tr|F7D2J8|F7D2J8_HORSE Uncharacterized protein OS=Equus caballus GN=EPAS1 PE=4 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGF
IAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGFGKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKV
YNNCPPHSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQV
VSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNG------------------------------
IF--DNSGEVAAKSNFLFTKLKEEPEELAQLAPTAGDAIISLDFAM-SPWSQNFEESSAYGKA-I--------LPPSQPWAGELRSSE-PAFTVPQAASS
S--S--------PSSPGDYYTSLND----DLKIEAIEKLFAMDTEAKDQCSTTDFNELDLETLAPYIPMDGDFQLSIC-PEERLLPNPQTNIFGT--KSL
PLCCGQASTPLSSMGGRSNTQWPPKWP-GASPPHK-P-RDPDTMSPAMIALSKLKLKRQLEYE-QDMSGA----PSHLMWKRMKSLRGGQYQDYGL-KSG
MASRLLGPSFEPY----LLPELTRYDCEVNVPVPGSSTLLQGGDLLRALDQAS--
>tr|W5P6T6|W5P6T6_SHEEP Uncharacterized protein OS=Ovis aries GN=EPAS1 PE=4 SV=1
----TLVSQLRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEADADQQMDNLYLKALEGF
IAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGFGKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKV
YSNCPPPQFCNTHSPNAENLPLLC-PLQHQTHLRIPVQSSVFLERISLNLLFFFSQFRITELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQV
VSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESPFKPHLLTMNS------------------------------
IF--DNSGKVAVKSNFLFTKLKEEPEELAQLAPTAGDTIISLDFG-----TPNFEESSAYGKG-I--------LPPSQQWTGEVKSSE-PAFTVPQAANS
S--S--------PSSPGDYYTSLDD----NLKIEAIEKLFAMDTEAKDQCGTTDFNELDLETLAPYIPMDGDFQLSIC-PEESLLPTPQTNTFGS--KSL
LQRCGQTYTPLSSMGGISSTQWPPKWP-GTVPPHK-P-QGPDVMSPAMIALSKLKLKRQLEYE-QDLSGG----PSHLMWKRMKSLRGGQYQDYSL-KSG
MASRLLGPSFEPY----LLPELTRYDCEVNVPVPGTSTLLQGGDLLRALDQAT--
>tr|H2SMF4|H2SMF4_TAKRU Uncharacterized protein (Fragment) OS=Takifugu rubripes GN=LOC101067536 PE=4 SV=1
----PRLSLCRTSSERRKEKSRDAARCRRSKETEVFYDLAHQLPLPHSVSAHLDKASIMRLAISFLRTRKLLDTSCSS-GSNCDEDKEMDSLYLKSLEGF
VAVVTSDGDMIYLSENINKFMGLTQVDLTGHSIFDFTHPCDHEEIRENLSLKTAYDKGKELSSERDFFMRMKCTVTTRGRTVNLKSAGWKVLHCTGQLKM
YNSCPPRGLCSFREPPLTCAVLMCEPIPHPSNIDTPMDTRTFLSRHSMDMKFTYCDERVTELMGYTPEDLLGRSVYDFYHALDSDKVTKSHQNLCTKGQA
VTAQYRMLAKNGGFIWVETQGTVIYNSRNSQPQCIVCINYVLSDIEEKSTIFSLEQIEALFKPRHMS---------------------------------
GF-LTEGGVGVVPGDALFTKLKEEPEDLTQLAPTPGDTIITLDFAR-P-QFEETRQAPGYG----------MALPDVPSWSNESLK---AAFTMQQHPSA
------------PSSPGDYYSSVDS----DLKVELTEKLLILDTEDNGPANTMDLSDLDLETLAPYIPMDGDFELNIE-PLE----NSNNS-SCMMAHQN
PPYRAPARTPLSSMGGRQNLQWPPKSFEQSIP--QS--TGVTSVLWPNVSNILLRSD-------CGGCQ---N----LLWVHSRAFIGP--------FPG
IASRLLGPSFEST----CLPELTRYDCEVNVPLQGNLHLLQGCDLLRALDQAT--
>tr|M4XYS7|M4XYS7_SEBSC Hypoxia-inducible factor-2 OS=Sebastes schlegelii GN=HIF-2 PE=2 SV=2
----AEKEKKRSSSERRKEKSRDAARCRRSKETEVFYELANQLPLPHSVSSHLDKASIMRLAISFLRTRKVVTTGC---SVDGDEDGQMDSLYLKSLEGF
VTVVTSDGDMIFLSENINKFMGLTQVDLTGHSIFDFTHPCDHEEIRENLSLKTGFGKGKELSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGTLKT
YSSCPPRVLCGFKEPPLTCAVLMCEPITHPSNIDTPLDSRTFLSRHSMDMKFTYCDDRVSELMGYSPEDLLGRSVYDFYHALDSDGVTKSHHNLCSKGQA
VSGKYRMLAKNGGYVWVETQGTVIYNSRNSQPQCIVCINYVLSDIEEKSMIFSLKQTESVFKPHHMN---------------------------------
NF-FSAGGAGVTPGDALFTKLKEEPEELAQLAPTPGDTIITLDFDR-P-QFEEPQQPAGYTTVSAAA----MPPPGPPSWASESHK---GAFTVQQNPSA
------------PSSPGDYYSSVDS----DLKVELTEKLFALDTEKDSPENTRDLSDLDLETLAPYIPMDGDFQLNII-PESEPL-S--NS-SYILGHQS
PPYQAPASTPLSSMGGRQNLQWPPKTYEQNAT--QR--QAYRDMSPARV---SIKRS-------TQMSV---G--SDLIWKKMRGDS--NYT-YNMQSQG
IASRLLGHSFESS----CLPQLTRYDCEVNVPLL---------------------
>tr|Q9W7C6|Q9W7C6_CHICK Endothelial PAS domain protein 1 OS=Gallus gallus GN=EPAS1 PE=2 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHNVSSHLDKASIMRLAISFLRTHKLLSSVCADNENELEADQQMDNLYLKALEGF
IAVVTQDGDMIFLSENVNKYMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGFGKNKEMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKV
YNTCPPHTLCGYKEPLLTCLIIMCEPIQHPSNIDIPLDSKTFMSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQV
VTGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIICVNYVLSEIEKNDIVFSMDQTESLFKPHLLTMSS------------------------------
AF--EN--GISGKSDLLFTKLKEEPEELAQLAPTPGDAIISLDFEL-HPGIQKFEEAPAYTSA-V--------LTPNKPWPVEVKSGE-PSFTMPQIASS
SNSSCSTP----N-SPEDYYTSVDD----DLKIEVIEKLFAMDTESKSQCNSTDFNELDLETLAPYIPMDGDFQLSIC-QEERTLSSAQSTVFMS-RSSL
PPYHNQASTPLSSMGGRPNTQWPPKWRT-SSPPNK-Q-RGID-INPARIALSSLKLKRQLDYE-QQLSGG-----PQLMWKRMKFLKG-HYQDYTVQKSG
VTSRLLGSSFEPY----LLPELTRYDCEVNVPVLGSSTLLQGSELLRALDQAT--
>tr|K7G1Q3|K7G1Q3_PELSI Uncharacterized protein OS=Pelodiscus sinensis GN=EPAS1 PE=4 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHNVSSHLDKASIMRLAISFLRTHKLLSSVCVDNESDLDIDQQIDNLYLKALEGF
IAVVTQDGDMIFLSENINKYMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKTGFGKNKEMSTDRDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKV
YNSCPSHSLCGYKEPLLTCLIIMCEPIQHPSNMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCAKGQI
VTGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIVCVNYVLSEIEKNDIVFSMDQTESLFKPHLLTMNT------------------------------
IF--DN--GVPVKSDFLFTKLKEEPEELAQLAPTPGDAIISLDFAQ-HNGTQKFEEASIYNKAAV--------LTLNKQWPGEVKSSE-PSFTMPQVASS
SNSSCST-----PSSPGDCYSSLDE----DLKIEMIEKLFAMDTESKNQCNSTDFNELDLETLAPYIPMDGDFQLSIC-QEERPLPNAPSAVFSNSKSSL
PPYHVRGSTPLASMVGRPGTQWPPKWRS-SSSPNK-Q-HGID-INPARTALASLKLKRQMDYE-QQRTGA-----SHLMWKRMKILKG-HYQNFNVQKSG
VTSRLLGQSYEPY----LLPELTRYDCEVNVPVLGSSTLLQGSDLLRALDQAT--
>tr|L7MG71|L7MG71_9ACAR Putative hypoxia-inducible factor 1 alpha subunit basic helix-loop-helix transcription factor b (Fragment) OS=Rhipicephalus pul
----SAPKERRKNSEKRKEKSRDAARCRRSKESEIFTELSQQLPLPESVACQLDKASVMRLAISYLRLREILEPIAEVA--KSAACSPYDSSVLEALDAV
LLVLSAEGEIVFLSDNVGRHLGLNQVDLMGQSVYEYCHPCDHDELKAALLPKP--EDHDLSPQPCHFLMRLRCTLGSKGRGVSVKSASYKMMQCVGTRVS
REVAPPEEEQPKEEERRHFLVCVAQPIPHPSNIEAPLGTHTFLSRHNPSMCFTHVDDRTETFLGYSSEELLGKSVYSYFDPRDVLNLQQDFKTLFAKGQC
ETGQYRFLAKHGGCVWVLTQATLIYENSCSKPQCVVCVNYVLSGASGKHEVLAEQQLTSTAVKPKEPEPK------------------------------
LQ-FLIFA----DTGFTAVLRDDEPEDLTHLAPRAGDDTIPLEGLPSLGDAFSL--SDIYGDEN-------KLLPDYALLPPEEDC---DPLSS----ST
PPSSD-------------SCSDVPSE-------SPVDRFAGLELKPE----GTDLQDDDFDMRAPYISMNGDFPLL-PDPQDSSP--GSNT---------
---------PKSSLAALLVAELPPEWTHSGPHHPQSGLSAASDGRPHAYV--TTALEQKMGMPSTERAL------QLASPKRMRIDLRG-YDKRCPPP--
-APLLLD-----P----TLQDLSQLDAEVNAPIQ---QLLTGEDLLSALDQSV--
>tr|V5HIH3|V5HIH3_IXORI Putative hypoxia-inducible factor 1 (Fragment) OS=Ixodes ricinus PE=2 SV=1
---------RRKNSEKRKEKSRDAARCRRSKESEIFSELSQQLPLAEGVTSQLDKASVMRLAISYLRMHEILEPIVELK--EKKVSSAYDASVLEALDGF
LVVLSADGDVLFLSENISRHLGLNQVDLMGQSLFEFCHPCDHDELKEVLCPGGKAPEGEKFPQPCSFFVRLRCALGSKGRGVGVKSASYKVLHCVGHRVL
RDVAPREDDPEEEEEQRRFVVCVAQPIPHPSNIEVPLGSRTFLSRHSPSMRFTHVDDRIEKFLGYTSDELLGKSVYSYFDARDISALQKDFKTLFSKGQC
ETGQYRFLSKHGGYVWVLTQATLIYENSCSRPQCVVCVNYVLSGTSQEHEVVSEDQVIKAAAAPEPSE-K------------------------------
RP-FLMFA----DSGLTVLKEDSDPEDLTHLAPQAGDDSIPLEELPSLGDTFVL--SDPYGDNS-------KLLPDYALLPPEEDC---DPLSS----ST
PPASD-------S-CSDSLLSDVPSE-------SPVDRFAGLDLRPD----GTDLQEDEFDMRAPYISMSGDFPLLPPDPQDSPQ--GSDT---------
---------PKSSLAALLVSPELPDWGQR-ATGRNAGDTAGDGRRHGVYV--TAPLEQKMAMPSS-GGG------ALGSPKRMRVDPQG-YDRRFPAP--
-APLLLD-----P----SLQDLSQLDAEVNAPIQ---QLLTGEDLLNALDQSV--
>tr|C0HAF0|C0HAF0_SALSA Hypoxia-inducible factor 1 alpha OS=Salmo salar GN=HIF1A PE=2 SV=1
----VPEKKSRVSSERRKEKSRDAARYRRGKESEVFYELAQELPLPHSVTSNLDKASIMRLAISYLHMRKLLSTDDKTVEEESEMDSQLNVSYLKALEGF
LMVLSEDGDMIYLSENVNKYLGLAQFDLTGLSVFEYTHPCDHEELREILVHRT-TSKSKGPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHV--
--APAEQNPCGHKEPPVSYLVLVCDPIPHPSNIEAPLDTKTFLSRHTLDMKFTYCDERT-ELMGYDPEDLLNRSVYEYYHALDSDHLIKTHHNLFVKGQV
STGQYRMLAKIGGFVWVETQATVIYNNKNSQPQCVVSVNFVLSGIE-EKMVLSLEQTEDMRSVKKELVEE------------------------------
E-ELFTQAMEP-PLASLYDRLKEEPEALNLLAPAVGDTIISLDFSNPD---ILLKEVPLYNDVMLPSTSDKLALPHSMQPPSEQPL----------KAST
P-----------PDIALNFCFPMDSDISAALKLDLVERLFAIDTEPKTPFTSQGMEDLDLEMLAPYIPMDDDFQLRLS-PEEPLS----EP-------LT
QDVHSYTDSPFSAPSIRTASP---PAS---------APQMDREIYLRTLATQ-SQRKRKLALYQ--------G-NPPGPGKKLKVSEL-SNRTILLLPTD
LASCLLGISSEGF----TLPQLTRYDCEVNAPVVGRQHLLQGEDLLCALDQVN--
>tr|A5H732|A5H732_ESOLU Hypoxia-inducible factor 1 alpha OS=Esox lucius GN=HIF-1a PE=2 SV=1
----VPEKKSRVSSERRKEKSRDAARCRRGKESEVFYELAQELPLPHSITSNLDKASIMRLAISYLRMRNLLSTDEGAVEEESELDSQFNGSYLKALEGF
VMVLSEDGDMIYLSENVNKCLGLAQFDLTGLSVFEYAHPCDHEELREMLVYRT-TSKSKEPNTDRSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
HEVPAEQGSCGHKEVPVPYLVLVCDPIPHPSNIEAPLDTKTFLSRHTLNMKFTYCDERT-ELMGYNPEDLLNRSVYEYYHALDSDHLTKTHHNLFTKGQV
STGQYRMLAKRGGFVWLETQATVIYNNKNSQPQCVVCVNYVLSGIEEEKLVLSLEQIEDMRPVKKERIEE------------------------------
EEVLFTQAMEK-PVTSLYDRLKAEPEALTVLAPAAGDTIISLDFSSPD---VLLKEVPLYNDVMLPSTSDKLALPLSLLPPSEQPL----------KASN
P-----------PDGPLDFCFPMDSDINSAFKLDLVESLFAIDTEPKTPFSSQAMEDLDLEMLAPYIPMDDDFQLRLS-PEEPLT----DP-------LT
KEVHNYPGSPFSAPSSQTTSPAPASAS---------AP---QEISLSKLVTQ-AQRKRKLSLSQ--------G--PPDLGKKQKVCDR-SNRTVLLLPTD
LASRLLGISSEGF----TLPQLTRYDCEVNAPVAGRQHLLQGEELLRALDQVN--
>sp|Q98SW2|HIF1A_ONCMY Hypoxia-inducible factor 1-alpha OS=Oncorhynchus mykiss GN=hif1a PE=2 SV=1
----VPEKKSRVSSDRRKEKSRDAARCRRGKESEVFYELAQELPLPHSVTSNLDKASIMRLAISYLHMRNLLSTDNE--EEEREMDSQLNGSYLKAIEGF
LMVLSEDGDMIYLSENVNKCLGLAQIDLTGLSVFEYTHPCDHEELREMLVHRT-TSKSKEPNTERSFFLRMKCTLTNRGRTVNVKSATWKVLHCSDHVRV
HESPAEQIPGGHKEPSVPYLVLVCDPIPHPSNIEAPLDTKTFLSRHTLDMKFTYCDERT-ELMGYDPEDLLNRSVYEYYHALDSDHLMKTHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNYVLSGIEEEKMMLSLEQTEDMRPVKKELE--------------------------------
---LFTRAVET-PLSSLYDRLKEEPEALTLLAPAAGDTIISLDFSSPD---ILQKEVPLYKDVMLPSTSDKLALPLSLLPPSDQHL---V------STST
P-----------PDSPLDFCFPMESDINAEFKLDMVETLFAINPEPKTPFTLQAMEDLDLEMLAPYIPMDDDFQLRLS-PEEPLS----ES-------LT
QEVHSYPGSPFNAPGSLTASPALAPAS---------VPQMDREISLRSLASQ-AQRKRKMSLSQ--------G--HPGPGKKLKVSEL-FNRTILLLPTD
LASRLLGISSEGF----TLPQLTRYDCEVNAPVGGRQLLLQGEELLSALDQVN--
>tr|F1QNB9|F1QNB9_DANRE Hypoxia-inducible factor 1 alpha A OS=Danio rerio GN=hif1aa PE=2 SV=2
----APG-KKRVSSERRKEKSRDAARCRRGKESEVFYELSRELPLPHSVTSNLDKASVMRLALSYLRLRKLLNSDVLE-K-ETALDTQWNGSFLKALDGF
LLVLSADGDIVYLSENVSKCLGLPQIELTGHSVFEFTHPCDHEELREMLAHRF-LSKSKDQNTNRSFLLRMKCTLTSRGRTVNVKSASWKVLRCSGRIHT
ADGV-EKEVCEEKNTCSTYLVLICESIPHPANIEAPLDSRTFLSRHTLDMRFTYCDERT-ELLGFDPEDVLQHSVYEYYHALDSDHMTKTHHSLFVKGQV
CTGQYRLLAKAGGFVWAETQATVIYNSKNSQAQCVVCVNYILSGIEQPKQILSLQQTNSTKIKQEEHQE-------------------------------
------KEDEEC-PVVQHNSLKGETEALTVA-----DPVLTLDINIT--AISVLTEIPLYNDVMLPSSDV--LLPLSPLSPPCSSL---G------HLQ-
------------DSSRSQVDLPVDSELCDQLKPDHVEKHFSMDIESK----TQGV-GLDLEMLAPYIPMDDDFQLRVS-PVRPMC----DP-------ST
QTSPALSAAT---PDSLSCDPVQQKTT---------EIIQD--SDISYKCQTPKLLKRKLETIPEAIRLGVLQ-T--FPEKKVRKTDA-RHATILLLPSN
VASRLLSRSSEGM----PLPQITHHDCEVNAPVIGRQHLLQGEELLCALDLVI--
>tr|A0A0B5L0A0|A0A0B5L0A0_9TELE Hypoxia-inducible factor 1 alpha A OS=Gymnocypris namensis PE=2 SV=1
----APG-KKRVSSERRKEKSRDAARCRRGKESEVFYELARELPLPHGVTSNLDKASVMRLALSYLRLRKLLNTDVLN-V-ESELDSQWNSSYLKALDGF
LMVLSADGDIVYLSENVSKCLGLPQIDLTGHSVFEFTHPCDHEELREMLAHRT-LSKAKEQHTNRSFLLRMKCTLTSRGRTVNVKSASWKVLRCSGQIHT
TDGI-KKGVCEEKNVCSTYLVLICESIPHPAYIEAPLDSRTFLSRHTLDMRFTYCDERI-ELLGFEPGDLLQHSVYEYYHALDSDHMTKTHHNLFVKGQV
CTGQYRLLAKAGGFAWAETQATVIYNSKNSQPQCVVCVNYILSGIEQPKQILSLQQTNSTKMKQDHEEHH------------------------------
EES--NEKKEEC-E-ELCDS-------MTVA-----DLVLTLDITST--ALSVLTEIPLYNDVMLPSSSV--LLPLSPLSPPCSSL---T------HLD-
------------DSSRSQVDFPVDSELSDQLKPDHVERLFSMDIESKTPFNTQGV-GLDLEMLAPYIPMDDDFQLRVS-PAESMC----EP-------ST
QTAPALPGAP---LDIVSRDTVPQRTT---------EMIQDDESDISSKCQTTKLLKRKLETIPEAIRLGVLQ-T--FPEKKVRKSDS-RHATILVLPSD
VASRLLSRSSEGM----PLPQLTRYVCEVNAPVTGRQHLLQGEELLCALDLVI--
>tr|Q3S3U2|Q3S3U2_DICLA Hypoxia-inducible factor OS=Dicentrarchus labrax PE=2 SV=2
----VPETESRVSSERRKEKSRDAARCRRGKESEVFYELAQELPLPHSVSSSLDKASIMRLTISYLRMRKLLNTDEPM-KEETDLDLQLNSSYLKALEGF
LMVLSEDGDMIYLSENINKCLGLAQFDLTGHSVFDFIHPCDQDELREMLVHRT-GSKSKEPNTGRSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVHV
YDSHTEESTNGQKEPPIPYLVLICDPVPHPSNIEVPLDSKTFLSRHTMDMKFTYCDERT-ELMGYDPEDLLNRSVYEYYHAQDSDHLTKTHQNLFAKGQV
CTGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQIEDVKPVKAELQQG------------------------------
EEKLFTQAVAA-SLVSLYDRLKEEPEALTLLAPAPGDTIISLDFSCP--EIPMMNDVPVYNDVMLPSTSDKLALPLSPLPPSEPLH---Q------RYPT
PAS---------PGSPLDFCFPMESDMSSDFKLDLVEKLFAIDTEPKTPFTTQAPEDFDLETLAPYIPMDDDFQLRVT-PDEPLS----QP-------VT
QDVHCY-----KSPGSRTASPAPPLAT---------TTQLDKEVSLSTLAAQ-TPRKRKLCDIK-----------QLEQGKKLKASES-TTTTILLLPSD
LASRLLGSSSEGF----TLPQLTRDDCEVNAPLQGRQYLLQGEELLRALDHVN--
>tr|M9NZ78|M9NZ78_SPAAU Hypoxia inducible factor-1 alpha OS=Sparus aurata GN=HIF-1 PE=2 SV=1
----VPEK-KRVSSERRKEKSRDAARCRRGKESEVLYELAQELPLPHSVSSSLDKASIMRLTISYLRMRKLLSTDEPM-AEEKELDLQLNSSYLKALDGF
LMVLSEDGDMIYLSENINKCLGLAQFDLTGHSVFDFIHPCDQEELREMLVHRT-GSKAKETNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YESHTEETPNGQKEPPVPYLVLICDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPEDLLNRSVYEYYHAQDSDHLTKTHHNLFAKGQV
CTGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQTEDVKPIKEEPQHD------------------------------
TDQLFTRVAEA-SVASLYDQLKEEPEALTLLAPAAGDTIISLDFSSP--EIQLLHDVPLYNDVMLPSISDKLVLPLSPLPPSEPLH---E------HYTS
LAS---------TDSPMDFCFPMDSEMSSDFKLDLVEKLFAIDTEPKNPFTTQAMED--LEMLAPYIPMDDDFQLRLP-PDEPLT----QP-------VK
QDIPSYPSSPFSSPGSRTASPAPPLAT---------TTQLNKEVSLGTLAAL-TQRKRKLGDIK-----------QQEQGKKLKSSES-TT-R-TILPSD
LASRLLGSTSEGF----TLPQLTRDDCEVNAPLQGRQYLLQGEELLRALDHIN--
>tr|Q2ESI1|Q2ESI1_MICUN Hypoxia-inducible factor 1 alpha OS=Micropogonias undulatus PE=2 SV=1
----VPEK-KRVSSERRKEKSRDAARCRRGKESEVFYELAQELPLPHSVSSSLDKASIMRLTISYLRMRKLLSTDEPI-AEETDLDFQLNGSYLKALDGF
FMVLSEDGDMIYLSENINKCLGLAQFDLTGHSVFDFTHPCDHEELREMLVHRT-GSKAKEPNTERSFFIRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
SDSCTEQTTSGQKEPPVPYLVLICDPIPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPDDLLNRSVYEYYHAQDSDHLTKTHHNLFAKGQV
CTGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQTEDVKPVKEELQPE------------------------------
EEELFTRAIES-TLVSLYDQLKEEPEALTLLAPAPGDTIVPLDFSCP--EIQ----LPLYNDVMLPSTSDKLALPLSPLPPSEPLH---E------RYPT
TAS---------ADSPLDFCFPMDSDMSSDFKLDLVEKLFAIDTEPKTPFTTQAVEDLDLEMLAPYIPMDDDFQLRLP-QEEPLS----DP-------VT
QDIQSYPSSPFSSPGSRTASPAPPLAT---------TTQLGNEVSLRTLAAQ-SQRKRKLCDIK-----------ELEQGKKLKASES-TT-TILLLPSD
LASRLLGSTSENF----TLPQLTRDDCEVNAPLQGRQYLLQGEELLRALDHVI--
>tr|A5H736|A5H736_GASAC Hypoxia-inducible factor 1 alpha OS=Gasterosteus aculeatus GN=HIF-1a PE=2 SV=1
----VPEK-KRVSSERRKEKSRDAARCRRGKESEVFYELAQELPLPHSVTSGLDKASIMRLIISYLCMRKLLHNDEPV-TEETELESQINSAYLKALDGF
LLVLSEDGDMIYLSENVNKCLGMAQFDLTGQSVFDFIHPCDQEELREMLVHKT-GSKAKEADTKRSFFLRMKCTLTNRGRTVNVKSATWKVLHCSGHVRV
HDNPTEETSNGHKEPPAPYLVLICDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPEDLLDRSVYEYYHALDSDHLNKTHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSMDQIEGVKPVTEELLQQ------------------------------
AEKLFTRAAEV-SPASLYDQLKAEPEALTLLAPAAGDAVISLDFSCP--EILLVKEVPLYNDVMLPSTGDQLTPPLSPLPLSETLR---K------SYRS
STI---------ADSPLDFCYPMDSEMSSDFKLDLVERLFAIDTETKTPFTTQAMEDLDLEMLAPYIPMDDDFQLRLT-PEESLS----QP-------VT
QDIHSYPSSPFSAPGSRTASPAP-PAT---------IPQPDKEVSLMTLAAA-SQRKRKLGDAI-----------QVEQGKKLKASPS-TTRTIFLLPSD
LASRLLGSTSDGF----TLPQLTRYDCEVNAPLQGRQSLLQGEELLCALDLVN--
>tr|D7R4L3|D7R4L3_9TELE Hypoxia-inducible factor 1 alpha OS=Callionymus valenciennei GN=HIF-1a PE=2 SV=1
----GPEK-KRVSSERRKEKSRDAARCRRGKESEVFFELAKQLPLPPGSSSSLDKASIMRLTISYLRMRKLLGSDKAK-EAGSELDLHFNSSYLKALEGF
LMVLSEDGDMIYVSDNVNKCLGLAQLDLAGHSVFNFTHPCDQEELRETLQHRA-GTKSRDVNSARSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHLYD
SE---------PSDGSVPYLVLICDPIPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPDELLNRSVYEYYHALDSNHLTKTHHNLFAKGQV
ITGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGVQEEQTILSLEQTQDVKSVKEEKAQE------------------------------
EESLLSPAQED-PPSSLYERLKEEPEGLTQLAPAAGDTIISLDFSCPE--VHIL-KDPLYNDVMLPSTSSKVALS----PPSEASA---K------TFT-
------------VVTSLDFCFPVDSDMNPDFKLDLVEKLFTINTQPKTPFASQPLGDLDLDMLAPYIPMDDDFQLRLN-PDEPVR-----P---------
--LHDYSSS----PASRTRSPEP-LAS---------TPQLDKEVSLRTLVAQ-AQRKRKLGELR-----------QVEAVKKLKPSDL---KTFILLPSD
LASRLLGSTSDGL----SLPQLTRYDCEVNVPLQGRQYLLQGEELLRALDNVN--
>tr|Q2PMW1|Q2PMW1_ORYME Hypoxia-inducible factor 1 alpha OS=Oryzias melastigma PE=2 SV=1
----VPEK-KRVSSERRKEKSRDAARCRRGKESEVFYELATLLPLPHSVSSSLDKASVMRLTISYLRMRKLLGSDEPK-QEETELDMKFNSSYLKALDGF
LMVLSEDGDIIYLSENVNKCLGLAQFDLTGQNVFDYTHPCDQEELREMLVYRT-GSKAKEPNSERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVHV
NGVQAEQNSNGQKEPPVPYLVLICDPIPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPEDLLNRSIYEYYHALDSDHLTKTHHNLFAKGQV
CTGRYRMLAKSGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLIMSLDQIEDVKSVKEEPQEA------------------------------
DEAHFKKMAQS-PFDTLYDQLKEEPEALTLLAPAAGDTIISLDFSQPEPEIHLLKDAPLYNDVMLLSTSDKLALPLSPLPPSEALS---E------SPPT
LI----------TDSSIDYCFPMDSEENSEFKLDLVEKMFAIDTESKTPFNTQ---DLDLEMLAPYISMDDDFQLPVT-VEEPQP----KP-------VT
KDALSYPTPQLNPLSGCTASPGPPLPA---------AGNLEKDVHPCSPAAP-TQRKRKLSDLM-----------ELEKGKKLKPSEL-TTRTVLLVPSD
LASRLLGTTSESF----TLPQLTRYDCEVNAPLQGRQYLLQGEELLRALDHVI--
>tr|I3KW40|I3KW40_ORENI Uncharacterized protein OS=Oreochromis niloticus GN=LOC100703737 PE=4 SV=1
----VPEKKSRATSERRKEKSRDAARCRRGKESEVFYELAQQLPLSHSVSSSLDKASIMRLTISYLRMRKLLSTDEPP-TEDAELDMQLNSSYLKALEGF
LMVLSEDGDMIYLSENVSKCLGLAQFDLTGHSVFDFTHPCDQEELREMLVHRT-GSKSKEPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCTGHVRV
YDSPAEEGTNGQKEPPVPYLVLICDPIPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-DLMGYDPEDLLDRSVYEYYHALDSDHLTKTHHNLFAKGQV
CTGQYRMLAKKGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSVKQTADVKPVKEEHQEE------------------------------
D-QILTDSAVT-LPVNLYDHLKGEPEALTMLAPAAGDTIVSLDFSCPESDIHLLKDVPLYNDVMLPSTDDKLVLPLSPLPPSEPLN---E------SYQT
TTS---------PGSPLDFCFPMDSEMNSDFKLDLVEKLFAIDTEPKTPFNTQEMEDFDLEMLAPYIPMDDDFQLLLP-PGEPLS----EP---------
--IHSYPSSPFSAPGSRTASPAPPPPT---------APKLEKEVPLRTLAVQ-AQRKRKICDLK-----------QVEKGKKLKPSGS-TTRTIVLLSSD
LASRLLGSTSEAF----GLPLLTRDDCEVNAPLQGRQYLLQGEELLRALDHIN--
>tr|A0A087XQT7|A0A087XQT7_POEFO Uncharacterized protein OS=Poecilia formosa PE=4 SV=2
----IPEK-KRVSSERRKEKSRDAARCRRGKESEVFYELSKQLPIPHSTSSNLDKASVMRLTISYLRMQKLLCIDEPV-AETTELDIQLNGSYLKALDGF
LVVLSEDGDIIYISENVNKCLGLAQFDLIGHSVFDFTHPCDQEELREMLVYRS-GSKVKEPSTERNFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
HSS--EQSANGHKEPPVPYLVLICDPIPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPEDLLNRSVYEYYHALDSDYLTKTHHHLFAKGQV
TTGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQTQEMKPVKKEEEEE------------------------------
EQQFQDLVIKQ-EQDCLYNLLKGHPDALMLLAPAAGDTIISLDFSRPESETHLLKDVPLYNDVMLPSSGGKLPLPLSPLAPTEPLE---N------SFLK
PPN---------VDNPLGFSFPMDTEMNSDFKLDLVEKLFAIDPEPKTPFNTEAMEDSELEMFAPYISMDDDFQLPLG-PDEPLS----EP-------VT
PELHSHPSSPFSAPESRTASPAPPPAT---------VAQPEKEVPLRNLAAQ-VQRKRKLSELK-----------QPEKGKKLKATEL-ATRTILLLPSD
LASRLLGTTSDGL----SLPQLTSYDCEVNAPLQGRQYLLQGEELLRALDHVI--
>tr|Q4H3E3|Q4H3E3_CIOIN Transcription factor protein OS=Ciona intestinalis GN=Ci-HIF PE=2 SV=1
----EEVPPSTYRRQRRREKSRDAARCRRNKECDIFQEICDNLPVAHDVIGQLDRSALLRLVISYIKLRQALPKTMFSDSQENPAPVISNDDYVNALNGF
ILIISTDYDILYASENVKEYLGLSHLDLIVQNILSYTHEGDHDDIRNCFRESE------GKSLRKSFFLRMKSTLTPNGKTTNLKSASYKVLRCTGMITP
SQAQS----------DTSAFVAHVQPIPHPSNIQHVLDSRTFLSRHSPDMKFTYWDERMSEILDYDAEGLMGKSFYDYVHVMDAKAIANSFQKLYRLGQI
ETERYRFLNKNGGYHWVITQATVITGNKNQKAQCVVCIHYVIGESTETEVIFSSEQLQCARLLQIKEQEA------------------------------
TIS-------------VFPVNTAMPEEQ---QPADDCSIVPLTFAVLND--------NLCGDDV--------------------------FFNAPSI---
-------------GDPWSFTSSATS------VQEKLEDLFSYVAVNLAPQ-AQEFCDMSKPQCAPLTH-----QLN--GRGENPS-APVSP---------
QRKRAYQNVPVSSEQYREHQE---RGF-------AK---------RKRYR--ESECNRKLADMPY--EL------TAQPTKQANNMN--LTSNFLLQFAN
TTGRGLPRNSS-G----ILPELSLHDCEVNAPLPGRGFFPVGVECVHALDEVF--
>tr|H3DIY3|H3DIY3_TETNG Uncharacterized protein OS=Tetraodon nigroviridis PE=4 SV=1
----IVPEKKRVSSERRKEKSRDAARCRRGKESEVFYQLAQELPLPHSVSSSLDKASIMRLTISYLRMRILLNAGEPL-TEETDLDLQLNGCYLKALDGF
LMVLSEDGDMIYLSENISKCLGLAQFDLTGHSVFDFIHPCDQEELREMLIHRT-GSKAKEPNTERRFFLRMKCTLTSRGRTVNVKSATWKVLHCLGHVRV
HESPAEPDPDGAQPSAVPYLVLICDPIPHPANIEFPLDTKTFLSRHTMDMKFTYCDE-T-ELMGYDPEDLLNRSVYEYYHAQDSDHLTKTHHNLFAKGQV
CTGQYRMLAKRGGFVWLETQATVIYNTKNSQPQCVVCVNFVLSGVQEEKMILSLEQTADVKPVKEELVGS------------------------------
PADLLPEEADG-PLSSLYDHLKRRPGALTMLAPAAGDTVVPLDFSCP--ELQLLKEVPLYNDVMLPSTSDKLVLPLSPLPPTGPLQ---K------HYSA
AAS---------VDAPHDLCFCTDSDMSSDFKLDLVEKLFTIDTEPRTPLTTQAMEDLDLEMLAPYIPMDYDFQLRLS-PDEALP----HS-------LS
QEIHSYPSSPFSSAGSRTPSPAPPLAT---------TTQLNKEADLRMLAAQ-ATRKRKLGEVP-----------QMEQGKKLKAS---TTRTILLLSTD
VATRLLGTTSEEF----SLPQLTRDDCEVNAPLQGRQYLLQGEELCAPWTTST--
>tr|H2U0Z2|H2U0Z2_TAKRU Uncharacterized protein OS=Takifugu rubripes GN=LOC101071027 PE=4 SV=1
----APEK-KRVSSERRKEKSRDAARCRRGKESEVFYQLAQELPLPHSISSSLDKASIMRLAISYLRMRKLLNAGEPI-TEETDLDLQLNGSYLKALDGF
LMVLSEDGDMIYLSENIIKCLGLAQFDLTGHSVFDFIHPCDQEELREMLIHRT-GSKAKEPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGQVRV
YENHTEPSPDEQKESAVPYLVLICDPIPHPANIEFPLDTKTFLSRHTMDMKFTDCDERT-ELMGYEPEDLLNRSVYEYYHAQDSDHLAKTHHNLFAKGQV
CTGQYRMLAKRGGFVWLETQATVIYNTKNSQPQCVVCVNFVLSGIQEEKMVLSLEQTADVKPVKEELLQE------------------------------
E--MLTEVTES-PVSSLYDKLKEKPEALTLLAPAAGDTIISLDFSCP--EMQLLKEVPLYNDVMLPSTSEKLVLPLSPLPPSEPLH---K------RCST
PASSS-------VDGPHDLCFCMDSDMSSDFKLDLVEKLFTIDTEPKTPFTTQAMEDLDLEMLAPYISMDDDFQLRLS-PDEALP----QS-------LT
PEVPSYPGSPFSLPDSCTASPAPPLATS--------TTQLNKEVELRTLAAQ-TPRKRKLADVKRSQGVNLID-EQMEQGKKLKASDM-TTRTILLLPTD
LATRLLGTTSEDF----SLPQLTRDDCEVNAPLQGRQFLLQGEELLRALDHVN--
>tr|A0A067Y838|A0A067Y838_BRAFL Hypoxia inducible factor alpha subunit long form OS=Branchiostoma floridae GN=Hifa PE=2 SV=1
----TLCRPKRRNSEKRKEKSRDAARVRRSKETEIFYELAHQLPLAHSKSAQLDKASIMRLAISYLKTRMIFADTEVV-KVESTTDQQMSDQYLKAMEGF
VLSLSDEGDILYLSENVCKYLGLTQLELTGHSIFDFTHPCDHEEIRDVLCTKN-----YTKNKACSFFMRMKCTLTSKGRNVNLKSATYKVIHCQGYLRS
YNNSQ-VNSLGCKEPPLLCLVAIGEPIPHPSNIEFPLDCKTFLSRHSMDMKFTYCDERITELLGHDPASLLGKGVYDYCHALDAERLERMHRCLYQKGQV
TTGQYRLLARRSGYAWVETQATIIYNNRTEKPQCIVCVNYVISDIEEEENVLSSEQASQKKFPKVEKIEE------------------------------
EPQFFW---------DGEQALRDSPEDLTRVAPAAGDAMIPLGFPSA-----------LFGSSSLPD----TSL--DPGFGQEDLF---SPFSSAGSSAT
PLSDD-------PNSDLDFMDQLMGRTTSDPDLTAINPSLALDTGPIAGKLTRPLTAEELSYRAPYIPAYQ--PLNPN---NAV-TVTSNPDSCCG--QE
LPFAAYASPQMMTMNGKHLRVAKVGGS-----NRTRTHMPGKHGPIGKLTFAGSKRKKLDE-DIQQPDRGTEG--DQPPAKKARVKAPNKIDVYKLL--N
FD----DFDLDDD----FLPPLTRADVEVNAPIQT-YKLLQGNDLMSALDQSA--
>tr|V5IV31|V5IV31_BRABE Hypoxia-inducible factor 1-alpha isoform a OS=Branchiostoma belcheri tsingtauense PE=2 SV=1
----TVTRPKRRNSEKRKEKSRDAARVRRTKETEIFYDLAHQLPLAHSKSAQLDKASIMRLTISYLKTRMIFADTEGV-KVESSTDQQMSDQYLKAMDGF
VLSLSDEGDIMYLSENVCKYLGLTQLELTGHSIFDFTHPCDHEEIRDVLCTKN-----YTKNKACSFFMRMKCTLTSKGRNVNLKSATYKVIHCQGYLRS
YNNSQ-VNSMGCKEPPLLCLVAIGEPIPHPSNIEFPLDCKTFLSRHSMDMKFTYCDERITELLGHDPANLLGKGVYDYCHALDAERLERKHRCLYQKGQV
TTGPYRLLARRSGYAWVETQATIIYNNRTEKPQCIVCVNYVISDVEEEGTVLSSEQASQKRLPKVEKVED------------------------------
-VKFFW---------DGEQALRDSPEDLTRVAPAAGDAMIPLGFPSP-----------LFGSSVLPDSFEKTSL--DPGFGQEDLF---SPFSSSDSSV-
--GDE-------PSGDMDFMDQLMGRTGSNPDLTAINPSMALDTGPIACKLNRPLTAEKLSYRAPHIPSYE--PLIPD---NSV-TFASNPNSCSG--GE
LPFAAYASPQMMTMNGKYLRVAKVGGQ--------ITHTPGKHGPVGKLTFAGSKRKELDEDDIQQPDRGTEG--NQPPAKKARLKAPNKIDVYKLL--N
FD----DFALDDD----CLPALKQTDIEVNIPMQT-CKLLQGNDLMSALDQSA--
>tr|A0A0P7UQ91|A0A0P7UQ91_9TELE Hypoxia-inducible factor 3a-like OS=Scleropages formosus GN=Z043_109809 PE=4 SV=1
MPPVSLSLGGRPSLEQRKVRSRDAARSRRSQETEVFYQLAHTLPFPRRVVSDLDKAAIMRVTLSFLRIHSLFHSGEVKVESAEEEEEAIDRFYPRALAGF
IMVLTEEGDMVFLSESVNKYVGITQLELLGQSVYDFVHPCDQEELRDVLTPRPGLSKKKDQRSERNFFLRMKSTLTNRGRVVNLKSAAWRVLRCSGHMRT
YHAADKT-----GPPIGNFLILLCEPIPDPSGVEFPLDCSAFLSRHSTDLRFIDCDDRVTQLVGYQPEDLTGRSAYEFHHALDSDHMTKSLHILFSKGQV
CTNQYRFLAKSGGYVWAETQATVTYNSKTSQPEAVVCLNFILSGVEHADVVFSMEQTPSLKKPKTEPEEKEE----------------------------
---------VGKGACAELLNLKELSEEVPQSSPTPGDVAVSKTESVEPKNLS------F----YRPPSPNTVPEFPQELCTPDLRQLLSPIFDRP----E
------------AASV----VSKCSGEDQFMDKDSVEKFFTFKPVDTNESTAEGTESMDLDMLAPYISMDDDFQLTFFTQLPESDLSS--PESP------
--------VPGAR--KR-------------YASCAKALEDDVET----SFRGILKDKRQRHTAVEEVLLAAKAPPEPVPH-HNKLLTDGGVQELRDPPEF
SQLSTNKRTFSRRP---PNNLCYGSATRITQLAVISPSYIQGEEYFVFGEG----
>tr|T1Q063|T1Q063_POLSE Hypoxia-inducible factor 3 alpha subunit OS=Polypterus senegalus PE=2 SV=1
----------MPRSELRKERSRDAARSRRSQETEVFYQLAHTLPLPRGVTSHLDKAAIMRLTLSFLRMKRILQNDS-----FREAEDDIDGYYLNAIAGF
VMVLSSEGDLIYLSENVSKHLGVPQLELVGQSIFDFVHPCDQEELRDILTSRHGYSKKKDIQTERNFFLRMKSTLTSNGRTVNLKSATWKVLQCSGHLRT
YHTEEDS-----TKE-LTCLTLICEPVPQPSTIDFPLDSRTFQSRHTMDLKYTHCEDRVFELLGYQPEDLIGRSAYEYHHALDSDHITKSFHILLSKGQM
STGHYRFLAKNGGFAWAETCATVLYNRKSSQPEGVICLTFILSGLEETEIVFSVEQTLRIMKLKKEPGSLDE----------------------------
----------ENKENCLFLKTSETTEEHTGMATALENNSVPLPDYAQPKDLS------F----SRAP-NDSLPESPQDLCTPELRQLLAPIFEKS----V
------------NEDSGIFMSSPRSVDEQAFDMDEIEKFFANKKESEMYAGVPQDEPLDLDMLAPYISMDDDFQLNFLSHLPEPLSPN--ADSH------
--------T--------LS----------GSNAKKRALEEEDDL----SSKKM--AWEKPDDSEEPVLLKALLDQMVN---QTKSILDDGVRSLCHSAAL
MSVFLDCLT----------------------------------------------
>tr|A0A0F8CNY0|A0A0F8CNY0_LARCR Hypoxia-inducible factor 1-alpha OS=Larimichthys crocea GN=EH28_08916 PE=4 SV=1
SSSSSSSSSCRTSSEQRKLRSRDAARCRRSQETEVFYELARTLPLPRRVSTHLDKSAIMRVSLSFLWLQRLLRPGGEKQKEEEEEGDPMDSFYPQALAGF
IMVMTEEGDMIYLTENVNRHIGITQLELLGQSIYDFVHPCDQEELRDLLTPRPGLSKKPEQPTERNFFLRMKSTLTSRGRTVNIKSATWKVLHCTGHVRP
FGGG-ST-----SPPAARVMTLLCEPIPHPSSVEFPLDTCTFLTRHSMDLRFTHCEGRVTELVGYKPDDLIGRSAYEFHHALDSDHVNKSLHTLLSKGQV
NTSHYRFLANSGGFVWAETQATVLYSSKTSQPEAVVCLNFILSAVEQPDVVFSVEQIRCGQAKTHTPAECG-----------------------------
----------SSSSADLFLKLKEQPGELLQLAPEAGDVIVPLT---DFVELS------F----FSGSSPDSVPDHPQDLCTPQLRQLLSPIFNPI----S
------------PPVSLLLDPEPSSPSEEVMDTSEVEKFFAICPEDVQGDAKDDMEGMDLEMLAPYISMDDDFQLTFLSGLPEESDKP--SSES------
--------SAGTS--AV-------------PLSRKRTHIPDEEL----LSHLMIQDKRQKQSSIEELLLSRLLQSDPRPGGRSRLLTDGGIQGLCDTAAL
MRDIFLS------P---PLSPMT--------------------------------
>tr|W5NAL6|W5NAL6_LEPOC Uncharacterized protein OS=Lepisosteus oculatus PE=4 SV=1
---PCGSPPRRPSSELRKVRSRDAARSRRSQETEVFYQLAHTLPLPRRVTSHLDKAAIMRITLSYMRMSRLFQAGGLKTDEEEEEEEEMDGYLTRALGGF
VMVLAPEGDMVYLSESVSKHIGITQLDLLGQSVFDFVHPCDQEELRDALTPRAGFSKKQDVPTERSFFIRMKSTLTSRGRTVNIKSASYKVLHCTGHIHT
YKSSGAQ-----EPPALTFLTLLCEPIPHPSNVEFPLDSSTFLSRHSLDLKFTHCDGRVTELVGYKPEDLIGRSAYEYHHALDSDHLTKSLHTLLSKGQV
TTSHYRFLAKNGGFVWAETQATVIYNGKTSQPEGVVCLNFILRGDQWLSSCFVFQSSGDESPMDTDSVEKF-----------------------------
----------PTAAKEVCVQSRHPRVDAGYFLGGSGFTVMTWD-----VMSG------F----A--ISHAS--LPPEKCCKIETRRGSNLYLSCN----T
------------L------------ANVALKDQPGREKMRFLVPNSVFFFPSTGYEALDLDMLAPYISMDDDFQLTFLAQLPESEPPT--LEPA------
--------A---------------------PGARKRTLKMDEDL----PLKESSPDKRKRQ---EEVLLHVLLSTEQLRL-AKSLLNTGGERGLCNSAAL
MSDLLPLTHELEAG---PISPLT--------------------------------
>tr|A0A060WKF5|A0A060WKF5_ONCMY Uncharacterized protein OS=Oncorhynchus mykiss GN=GSONMT00028434001 PE=4 SV=1
MDTKEEPVGKRSSTDQRKVRSRDAARCRRSLETELFYKLAHTLPLPRRVSADLDKAAIMRVTLSFLRMHHLRSG-DTSEDVTDGDEDTVDAFYPRALAGF
ILVMTEEGDMIYLGDSVSKHLGIPQLELLGQSVYDFVHPCDQEELRELLAPRPGVSKKKQQHTEINFFLRMKSTLTSRGRTVNIKSATWKVLHCTGHMRV
CCSGEDS-----SPPAGSFMTVLCEPIPHPSSVEFPLDRSTFLTRHSMDLCFTHCDGRVSELVGYEPEDLIGKSAYKFHHALDSDHVTKSLHILLSKGQV
CTSLYRFLAKSGGFVWAETQATVIYNNKTSQPEAVVCLNFILSVVEQADVVFSVEQTGCGLKSDPVSEASE-----------------------------
----------NSSSAELSLQLKENQEDLLQLAPVSGDPIVPLT---DFAEPS------F----SLPSSSDSAPDFPQELCTPELWKLLSPIFSKL----T
------------SSAPAL-VRTLIPIEELPIE-DEVAKLFAVCPDESVRNQPEDMEVVDLDMLAPYISMDDDFLLSV--QLPETPDSP--SPEP------
--------P---------------------TATRKRSHEQDEDM----PSQLMSQDKRPRHSPIHKLLLSALLNPGSIPHRRSQLLTDGEAQGLCDTAAL
MRDLFPLTSSLT-------------------------------------------
>tr|H3CMV6|H3CMV6_TETNG Uncharacterized protein OS=Tetraodon nigroviridis PE=4 SV=1
---QVNEQRFRGSTEQRKLRSRDAARYRRSQETEVFYELAHTLPLPRRVSTHLDKSAIMRVSLSFLRMRKLLQTADGDKR-ESEEDDPMDGFYPQTLAGF
IMVLTEEGDMIFLTENVNKYIGIVQLELLGQSIYDFVHPCDQEELTDLLAPRPGLNKKQEMPSDINFFLRMKSTLTARGRTVNIKSAEWKVLHCTGHMCP
FDAE-VS-----S--AARVMVLLCEPIPHPSSVEFPLDTYTFLTRHSMDLRFTHCEGRVTELVGYKPDDLIGRSAFEFHHALDSDHISRSLRTLLSKGQV
STSRYRFLANHGGFVWAETQATVLYNGKTSQPEAIVCLNFILSSVEQPDVVFSVEQVHCDRSEASSPA--------------------------------
----------PSSSAELCFEPEEKPEQLLQLAPEAGD-VVPLT--E-VAELS------F----LSPSSPNMVPENPQDLCSPQLLQLLTPIFSPM----T
------------PPPSSPSE---SDAEPELMDTSKVEKFFTFWSKDGQREKLKDTEEMDLEMLAPYISMDDDFQLTFLGTLSEEEDKN--PANL------
--------SPLST--AL-------------TANNKRSHNPDEEE----VSDLLSQAKRHRKSSMEELLNYYHLPADPERGGRSQLLTDGGLQGLSDTAAW
MKDIFLS------P---PVSLLT--------------------------------
>tr|G3PIK9|G3PIK9_GASAC Uncharacterized protein OS=Gasterosteus aculeatus PE=4 SV=1
EEKAETVVVKRTSSEQRKLRSRDAARCRRSQETEVFYELSSTLPLPRRVCTHLDKSAIMRVALSFLRMHHFLLQPGEKRVSSSPMEPPMDSFYPQALAGF
IMVMTEEGDMIYLTENVSTHIGIPQLELLGQSIYDFVHPCDQEELRDLLTPRPGSTKKPRQSSERNFFLRMKSTLTSRGRTVNIKSAAWKVLHCTGHVRQ
LGGA-SA-----VPPVGGVMTLLCEPIPHPSSVEFPLDTRTFLTRHSMDLHFTHCEGRVTELVGYKPEDLIGRSAYEFHHALDSDHVNKSLHTLLSKGQV
STRHYRFLANGGGFVWAETQATVLYNSKTSQPEAVVCLNYILSGVEQPDLVLSAEQTRCVRPHEAELCTPAV----------------------------
---------APSSAAVLVFKLKEESEEVLQLAPEVVNPIGPLT--GEFVGLS------F----SNPPSPNSLPDHPQDLCTSQLRQLLSPIFSPM----T
------------PPSSSSLDVESISCEEEVTDTSEVERFFAVWPDGQKVEPMEQMEVMDLEMLAPYISMDDDFQLTVHSSFPEDVDKP--PSSP------
--------SESSV--VAMA----------ATVSRKRAHNPDEEI----LSQLMVQDKRPKHPSIEELLLNRLLQSSPVAEGRSQLLTDGGIQ--------
-------------------------------------------------------
>tr|H2L9F9|H2L9F9_ORYLA Uncharacterized protein OS=Oryzias latipes GN=LOC101165163 PE=4 SV=1
EKEDETVAVKRTSSEQRKLRSRDAARCRRSQETEVFYELARTLPLPRKVCTHLDKAGIMRVTLSFLRMQQLLQPHEAGKETFNKKETPMDAFYPQALAGF
VMVMTEEGDMIFLTENVNKHIGITQLELLGQSIYDFVHPCDQEELRDLLTPRPGLSKKSEQPNEVNFFLRMKSTLTNRGRTVNIKSATWKVLHCSGHIRP
FS-G-SA-----APPGARVMTLLCEPIPHPSSVEFPLDTCTFLTRHSMDLRFTHCEGRVTELVGYKPEDLVGRSAYEFYHALDSDHMKKSLHTLLSKGQV
STSHYRFLANNGGFVWAETQATVLYSSKTSQPEAIVCLNFILSSVEQPDVVFSVEQTRSGLLSKTESP---N----------------------------
---------TPSSSARLFLKLKEEPEEILQLAPES-GDAVVLV--AAPVELS------F----SSPLSPDSVPDHPQELCTPQLRQLLSPIFDTL----T
------------PSSSPESA--LSAAQEEVMDIGEVERFFALCPEDVQTQTLENVEEMDLDMLAPYISMDDDFQLTLLNTLPEESIQA--ASES------
--------STRKR--VNQVV--------YADRVSFRTFESDDEM----LPQLLIQEKRQKQ---EELLLTRLLQTESSPGKCSQLLTDGGIQSLCDTAGL
MRDVFLS------P---PLSPMT--------------------------------
>tr|H2T9X1|H2T9X1_TAKRU Uncharacterized protein OS=Takifugu rubripes GN=LOC101062698 PE=4 SV=1
EEKEESISIKRSSSEQRKLRSRDAARYRRSQETEVFYELAHTLPLPRRVSTHLDKSAIMRVALSVLRMRQLVQAASESQK-KEPEEDPMDIFYPQTLGGF
IMVLTEEGDMIYLTENVNKYIGIVQLELLGQSVYDFIHPCDQEELTDLLTPRPGLNKKLDLPNDLNFFLRMKSTLTNRGRTVNIKSAEWKVLHCTGHMCP
FGGE-PS-----SPAAARVMVLLCEPIPHPSSVEFPLDTYTFLTRHSMDLRFTHCEGRVTELVGYKPDDLIGRSAFEFHHALDSDHISKSLRTVLSKGQV
STRHYRFLANNGGFVWAETQATVLYSGKTSQPEAIVCLNFILSSVEQPEFVFSIEQVHSDPPEANVPALAP-----------------------------
----------SSNAADLFFKLKEKPQELLQLAPEAGD-VVPLT--ADFSKLS------F----FSPSSPDTMPENPQDLCSPQLLQLLTPIFSPM----T
------------PPSSSTDAELPQSASEEVMDTSKVEKFFTIRPENSQGEKLKDSEEMDLAMLAPYISMDDDFQLTFLSSLSEEEDKR--SAPL------
--------RTLSA--AL-------------AANRKRSHNPDEDE----ASDLLIEDKRQKKSCIEELLNYYNLQPSAEGGGSSRLLTDGGMQGLSDTAAW
MKDIFLS------P---PASPLT--------------------------------
>tr|Q5IGQ1|Q5IGQ1_EPICO Hypoxia-inducible factor 4 alpha OS=Epinephelus coioides GN=HIF-4a PE=2 SV=1
EEKEEAVAVRRTSSEQRKLRSRDAARCRRSQESEVFYELAHTLPLPRRVCSHLDKSAIIRAAISFLRMHHLL-QPGEKQKESNEEEDPMDAFYPQALAGF
IMVMTEEGDMTYLTENVSRYIGITQLELLGQSIYDFVHPCDQEELRDLMAPRPGLSKKPQQQNERNFFLRMKSTLTSRGRTVNIKSAAWKVLHCTGYIHQ
FDGS-SR-----LSPAGRVMTLLCEPIPHPSSVEFPLGTCTFLTRHSMDLCFTHCEGRVTELVGYKPEDLIGRSAYEFHHALDSDHVNKSLHTLLSKGQV
STRHYRFLANSGGFVWAETQATVLYSSKMSKPKAVVCLNFVLSAVEQADVVFSMEQVRRGQPAEAEPLSPAL----------------------------
---------APSNSAELSFKLKEQPEELLQLAPAAGDIIVPLS--GENFELS------F----TRPVSPKSVPDNPQDLCTPQLRKLLSPIFSPI----T
------------PPSSSQNP-KRSPCEDEVLDNGEVDSFLAVWREVFQGQTLEDMEEMDLEMVAPYISMDDDFQLTVLSSLPEEADKP--LLSW------
--------PEPSS--VSRA----------ITVSRKRCHNQDNEM----LSQLMIQEKRQKHSSFEELLLSRLLRSEPVPGKQTKLLTDQGIQGLGDSAAV
MRNIFLS------P---TLSPIT--------------------------------
>tr|I3JLN1|I3JLN1_ORENI Uncharacterized protein OS=Oreochromis niloticus GN=LOC100708832 PE=4 SV=1
EKKEGVVAVKRTSSEQRKLRSRDAARCRRSQETEVFYELAHTLPLPRRVSTHLDKAAIMRVTLSFLRMHHLLRSDKNLKEEEEKDEDPMDAFYPQALAGF
IMVMTEEGDMIYLTENVNKHIGITQLELLGQSIYDFVHPCDQEELRDLLTPRPGLSKKSEQTSERNFFVRMKSTLTTRGRTVNIKSATWKVLHCTGQIRP
FGSG-SA-----SPPAGRVMTLLCEPIPHPSSVEFPLDTCTFLTRHSMDLRFTHCEGRVAELVGYKPDDLIGRSGFEFLHALDSDHINKSLHTLLSKGQV
STSQYRFLANNGGYVWAETQATVLYNSKTSQPDAIVCLNFILSSVEQPDVIFSMEQTRCSRVPKIEPADEDS----------------------------
----------SSSSAKLFMELREKPEELLQLAPDAGDTIVPLS--PGSVELS------F----ASPPSPDSVPEHPRDLCTPQLRKLLAPIFDPI----T
------------PPPSASPEPEQSRSEEEVMDTSEVEKFFAFWPEDAQD-TLVEMEGMDLDMLAPYISMDDDFQLTFLSSMTEEAEKP--SSSE------
--------SSA--------------------TSRKRTHDSAEEM----LSTVMLQDKRPKKPSIEELLLTKLLQPDPVPESRSHLLTDGGMQGLCDTAAL
MKDIFLS------P---PLSPMT--------------------------------
>tr|D9IL33|D9IL33_HYPMO Hypoxia-inducible factor-1alpha OS=Hypophthalmichthys molitrix GN=hif-1alpha PE=2 SV=1
MDTGVVTEKKRVSSERRKEKSRDAARSRRGKESEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLLSSDDNDKE--NGLESQLNGFYLKALDGF
LMVLSEDGDMVYLSENVSKSMGLTQFDLTGHSVFEFSHPCDHEELREMLVHRTVSKKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCAGHVRV
QERSEGS---------LTYLVLICDPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGYEPDDLLNKSVYEYYHALDSDHLTKTHHNLFAKGQA
TTGQYRMMAKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDIVLSLQQTMTEPKAVEKESQKME----------------------------
---------DPMECSDLYEQLKEEPEALTLLAPAAGDTIISLDFNNSDSDMQ------LVKDVMLPSSSEKLPISLSALTTPALSKLETGVEDFPFSANT
------------PSTSGLMDYQVDSDISSEFKLDLVEKLFAIDTEAK-PFTNQAIEDLDLEMRAPYIPMDDDFQLRIPSPLDPLPSSS--LSQI------
--------SVMSS--LFQPL--------PSPASVKKEPSSRPKM----LAIQNVQRKRKLETSLEAVGLGLLQSVVIEPGKRAKVLEVG-NRTILILPSD
VASRLLPSSIESNG---GLPQLTRYDCEVNAPVQDRHHLLQGEELLRALDQ----
>tr|Q2PQU6|Q2PQU6_9TELE Hypoxia inducible factor 1 alpha OS=Carassius carassius GN=HIF-1a PE=2 SV=1
MDSGVVTEKKRVSSERRKEKSRDAARSRRGKESEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLLSSDEEEKE--NELDCQLNSFYLKALEGF
LMVLSEDGDMVYLSENVSKSMGLTQFDLTGHSIFEFSHPCDHEELREMLVHKTGSKKTKEQNTERNFFLRMKCTLTSRGRTVNIKSATWKVLHCAGHVRV
QESSEDS---------LTYLVVICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGYEPDDLLNRSVYEYYHALDSDHLTKTHNNLFAKGQA
TTGQYRMLAKKGGFVWLETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDVVLSLQQTMTEPKAEEKENQEME----------------------------
---------DPVKSSELYEKLKEEPEALNVLAPSAGDTIISLDFNNSDSDMQ------LLKDVMLPSSSEKLPISLSPLTAPVLTKLETGAEDFPFCTNS
------------SSTSGLMEYQVDSDISSEFKLDLVEKLFAIDTEAK-PFSSQAMEDLDLEMLAPYIPMDDDFQLRIPSSLDLLPPGP---HSV------
--------SAMSS--LFQPL--------SSPVSVKQEHSSRPKM----LAVQNAQRKRKLETSLEAVGLNLLQSVAIAPGKRALVLELGGNKTILILPSD
VASRLLCSSLESSH---GLPQLTRYDCEVNAPVQDRHHLLQGEELLRALDQ----
>tr|A0A087YH60|A0A087YH60_POEFO Uncharacterized protein OS=Poecilia formosa PE=4 SV=2
-KEDGVVAVKRSSSEQRKLRSRDAARCRRSQETEVFYELARTLPLPRRVCTHLDKAGIMRVTLSFLRMQQLLRPEQSVKKEEEEEEDPMDAFFPQALAGF
VMVMTEEGDMVFLTENVNKHIGITQLELIGQSVYDFIHPCDQEELRDLLTPRPGLSKKLEQPSERNFFLRMKSTLTSRGRTVNIKSATWKVLHCTGHIRP
F--G-SA-----SPPAARVMTLLCEPIAHPSSVEFPLDSCTFLTRHTMDLRFTHCEGRVTELVGYKPEDLIGRSAYEFYHALDSDRIKKSLLTLLSKGQV
NTSPYRFLANSGGFVWAETQATVLYNNKTSQPEAVVCLNFILSAVEQPDVVFSVEQTRRSLLPKTEPSSPER----------------------------
---------TAGSSAKLLLGLAEKPEELLQLADGGE---PPLT--AGGVELS------F----ASPPSPDTVPDHPKDLCSPQLRQLLSPIFDGL----N
------------PSSSPASEPDLSPCEDEAMDTSEVERFFTICPEETQEQAAEDVEGKELEMYAPYISMDDDFQLTFLSDLPQEADKP--ASLL------
--------LQGAD--GSPA----------VTVSRKRTHDLDKEP----PPLLLIQDKRHKPTSIEELLLSRLLQSDSG---RSQLLTDS---ELCDTAAL
MRDIFLS------P---PLSPMT--------------------------------
>tr|Q6EGR9|Q6EGR9_DANRE Hif3a OS=Danio rerio GN=hif1al PE=2 SV=1
---MVNSTSKRPSLEQRKVRSRDAARCRRSQETEVFYELAHSLPLPRRIASHLDKAAIMRVTLSYLRMNRLIQS-GSTK-QTEKSETPTDGFYQQALAGF
ILVMTEEGDMVFLSESVSKYIGITQLELLGQSVYEFVHPCDQEELRDILATRPGVSKKK---MEHNFFLRMKSTLTHTGRTVNIKSATWKVLHCTGHMQP
FSGDDEN-----SPSAGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHNLDLTYTQCDGRVTELVGYQPDDLIGRSAFEFFHALDFDHVSRSLHILFSKGQV
CTGQYRFLTKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEQDVVFSLEQTCEKPKPKVERLMVLK----------------------------
---------EESSTAKLFLQMKENPEELLQLAPHSGDAIISLT---EGLELS------F----CCPQSPNSVPECPQDFCTPELRKLLSPIFDGP----A
------------KSPPA--A---SPAEELPMEMEGVEKFFALKPEESLKGQSEAVDELDLDMLAPYISMDDDFQLTFLPQSE--ITPP--LEML------
--------T---------------------SNSRKRCLEDDDDI----PVLAA--RWDKKQGSIDQLLLSTLLGSEPPPQKRSQLLTDGGVQALCDTAAL
MRDTFLRRPVAE-----TLPSLT--------------------------------
>tr|Q1L607|Q1L607_ICTPU Hypoxia induced factor-like factor OS=Ictalurus punctatus PE=2 SV=1
---MTTTEVKRPSSEQRKVRLRDAARCRRSQETEVFYELAHSLPLSRRITSHLDKAGIMRVTLSYLRMRHLLHSSWTKAA--EEEEDPTDAFYQQALAGF
ILVLNEDGDMVFLSDNVNKFIGITQLELLGQSVYEYVHPCDQEELRDLLTTKPGLFKKKDSCTECNFFLRLKSTLTSRGKTVNIKSATWKVVHCTGRMKT
LNQEGEG-----SSPVGSYMTLLCEPIPHPSCVEFPLDSSTFLTRHNMDLHFIQCDGRVTELVGYHPNDLIGRSAYDFIHALDFDHLTRSLHVLLSKGQV
CTYHYRFWLVNGGFVWTETHVHVLYNSRTSQPEAVVCLNFILSAVEEADTVFSVEQTRSEVNQDEPN--VIE----------------------------
---------V-SSSSELFHRFKNDPEDLLQLAPAPGDTIIPLT---VNTELF------F----CPPSSPTTVPKCPKELCTPKLRQLLSPIFDSS----C
------------PSSPD--L---SSADEVPMDTGEVEKFFANKPEET-KEPVQELDDMDLDMLAPYISMDEDFQLTFLPQLPEAETQA--AEAP------
--------S---------------------TASKKRGLE-KDDM----PSLTS--KWEKRLCPIEEFLLTSSLDLDPERWKQSQLLTDGGTQALCDTAAL
MPDSFLMARLTG-----TISLV---------------------------------
>tr|T1Q076|T1Q076_SCHPR Hypoxia-inducible factor 3 alpha subunit OS=Schizothorax prenanti PE=2 SV=1
---MVNSAMK--GLEQRKVRSRDAARCRRSQETEVFYELAHSLPLPRRIASHLDKAAIMRVALSYLRMNRLIQSAGPTK-PTEETENPTDAFYQQALAGF
ILVMTEEGDIVFLSESVSKYIGITQLELLGQSVYEFVHPCDQEELRDILATRPGVSKKKEKLTKHNFFLRMKSTLTHTGRTVNLKSATWKVLHCTGHMQT
FSGDGEN-----EPPAGSFLTLLCEPIPHPSSVEFLLDSSTFLTRHNMDLSFTQCDGRVTELVGYQPDDLIGRSAYEFYHALDFDHVTRSLHILFSKGQV
CTSHYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLYFILSGVEEADVVFSLEQTCEKPKPRAEKLSVPK----------------------------
---------EESSAANLFLQMKENPEELLQLAPHSGDDVISLT---DCVELS------F----CCPSSPTTVPECPQDFCTPELRELLSPIFDRP----T
------------KSPPA--A---SPAEELPMEMDGVEKFFALKPEESVKRQSEAMDELDLDMLAPYISMDDDFQLTLLPQGE--MVAP--SDML------
--------T---------------------KTSRKRCLEDEDDI----PVLAA--KWEKKPGSIEQFLLSTLLGSEQPPQKRSQLLTDGGVQALCDTAAL
MRDTFK-RPVAE-----TMPSLT--------------------------------
>tr|V9P0R0|V9P0R0_CLABA Hypoxia induced factor 3 alpha OS=Clarias batrachus GN=HIF-3 alpha PE=2 SV=1
---MTTTVAKRPSSEQRKVRLRDAARCRRSQETEVFYELAHSLPLSRRITSHLDKAGIMRVTLSYLRMRHLLHSSWTKVSTLEEEEEPTDAFYQQALAGF
ILVLSEEGDMVFLSENVNKFIGITQLELLGQCVYDYVHPCDQEELKDLLTTKPGLFKKKESCTECNFFLRLKSTLTSRGKTVNIKSATWKVVHCTGYMKT
LNQEGEA-----SSLAVSYMTLLCEPIPHPSCVEFPLDSSTFLTRHTMDLHFSQCDGRVTELVGYHPNDLIGRSAYDFFHALDFDHLTRCLHVLLSKGQV
CTSRYRFLAKNGGFVWTETQATVLYNSKTSQPEAVVCLNFILSAVEEADVVFSIEQTRSDLMQDKLS--VIE----------------------------
---------V--SSSELYHSLKDDPEDLLQLAPAPGDTIIPLT---GHTELF------F----VPPSSPNSVPKCPKELCTPKLRQLLSPIFDSS----C
------------PTSPD--H---SSGDEFSMDTGEVEKFFADKPEET-KKTMEDMDDLDLDMLAPYISMDEDFQLTFLPKLPEADTQT--PEAQ------
--------T---------------------TASKKRALD-EDDM----PSLTS--NWEKRRCPIDEFLLSSSLGLDPDRWKPSQLLTDGATKALCYTAAL
MRNSFLMAQLTG-----TISPLA--------------------------------
>tr|G4WI70|G4WI70_MYXAS Hypoxia-inducible factor 3a OS=Myxocyprinus asiaticus GN=HIF-3a PE=2 SV=1
---MVNSSGKRPSLEQRKVRSRDAARCRRSQETDVFYELAHSLPLPRRIASHLDKAAIMRVTLSYLRMNRLIQSGSTKT-SHEETEDPTDGFYQQALAGF
VMVMTEEGDMVFLSESVGKYIGITQLELLGQSVYEFVHPCDQEELRDILTTRPGLSKKKVKLTEHNFFLRMKSTLMHTGRTVNIKSATWKVLHCTGHIQT
LSSEDES-----STPGGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHNMDLTFTQCDGRVTELVGYEPDDLIGRSAYEFYHALDFDHVTSSLHILFSKGQV
CTSHYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEQADVVFSLEQTSDKPLPKAVKLSLLE----------------------------
---------EVSSTAELFLQMKENPEELLQLAPHSGDTIISLT---EGVDLS------F----GRPTSLNGIPECPQDFCTPELRQLLSPIFDKP----S
------------NSPHA--A---SPAEELPVEMDGVEKFFALKPAESVKGQTENMDELDLDMLAPYISMDDDFQLTFLPQCPETVTSS--PEML------
--------T---------------------NTSRKRCLEDDDDI----PALAA--KLEKRESSIERLLLSTLLGTEPPPQKRSQLLTDGGVQALCDTAAL
MRDTFLLRPVAE-----TTSTLT--------------------------------
>tr|W5KMK5|W5KMK5_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
----MESSPKRPSSDLRKVRSRDAARCRRSQETEVFYELAHSLPLARRVTSHLDKAGIMRVTLSYLRMRQLLCSSTTKVEGTEEEQDPTDAFYQQALSGF
VLVLTEEGDMIFLSENVSKYIGLAQLELLGQSVYDFVHPCDQEELRDILTSKTGLCKKKEKFIEHNFFLRMKSTLTSRGRTVNIKSAAWKVLHCTGHMQT
FSSELES-----SSATGSYLTLLCEPIPHPSCVEFPLDSSTFLSRHSMDLNFTQCDGRVTELVGYHPDELVGRSAYEFFHALDFDHVTKSLHILFSKGQV
CTSQYRFLAKNGGFVWIETQATVIYSSKTSQPEAVVCLNFILSGVEQAETVFSVEQTRCELKSEKPSLPVIK----------------------------
---------VSSSSAELFRKLKDNPEDLLQLAPAAEDTIILLT---EEMDLS------F----GPPSSPNGVPECPKDLCSPKLRQLLSPIFDSP----S
------------PASPA--S---NSGDELSMDTGDVEKFFAIKPEENTKELTKELEEMDLDMLAPYISMDDDFQLTFLPQFSETKLSS--SEEP------
--------A---------------------APSRKRGLE-DEDL----PSLTT--TWEKRQCSIDELLLSSSLASNTSPWRKNLLLTDGEPQLLCNTADL
IKNSFLRSQTAG-----TLLPHT--------------------------------
>tr|Q6STN6|Q6STN6_CTEID Hypoxia-inducible factor-4alpha OS=Ctenopharyngodon idella GN=hif-4alpha PE=2 SV=1
---MVNSVNKRPSLEQQKVRSRDAARCRRSQETEVFYELAHSLPLPRRITSHLDKAAIMRVTLSYLRMNRLIQSVGPTK-KTEETENPTDGFYQQALAGF
ILVMTEEGDMIFLSESVSKYIGITQLELLGQSVYEFVHPCDQEELRDILTTRPGISKKKEKLAEHNFFLRMKSTLTHTGRTVNMKSANWKVLHCTGHMQT
FSGDDET-----SLPAGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHSMDLTFTQCDGRVTELVGYQPDDLIGRSAYEFYHALDFDHVTRSLHILFSKGQV
CTSHYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEADVVFSLEQTCQKPKPKAEKLTVLE----------------------------
---------EESSTATLFLKIKENPEELMQLAPHSGDTIISLR---EGVELS------F----CQPPSPNSVPECPQDFCTPELRQLLSPIFDRP----T
------------KSPPA--A---SPAEELPMEMEGVEKFFALKPEESVKGQSEAMDELDLDMLAPYISMDDDFQLTFLPQSE--MAAS--SEML------
--------T---------------------NTSRKRCLEDEDDI----PVLAA--KWEKKQSSIEQLLLSTLLASEPPPQKRCQLLTDGGAQALCDTAAL
MKDTFLMRPVAE-----TMPITSE--T----------------------------
>tr|Q2ESI0|Q2ESI0_MICUN Hypoxia-inducible factor 2 alpha OS=Micropogonias undulatus PE=2 SV=1
----AEKEKKRSSSERRKEKSRDAARCRRSKETEVFYDLAHQLPLPHSVSSHLDKASIMRLAISFLRTRKLIATGCSSCSDGGDEDRQMDSLYLKSLEGF
VTVVTSDGDMIFLSENINKFMGLTQVDLTGHSIFDFTHPCDHEEIRENLSLKTGFGKGKELSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQLKM
YDSCPPRGLCGFKEPPLTCAVLMCEPIPHPSNIDTPMDSKTFLSRHSMDMKFTYCDERVTELMGYTPEDLLGRSIYDFYHALDSDSVTKSHHNLCTKGQA
VSGQYRMLAKNGGFVWVETQGTVIYNSRNSQPQCIVCINYVLSDIEEKSMIFSLEQTESLFKPRHMS---------------------------------
--SFFTAGGTGEPGDALFTKLKEEPEDLAQLAPTPGDTIISLDFGRP-----QFEEPQGYTQVSAT----AMPPPGPPSWASESHKTMASTFTVQQNPPT
GSPTPSLSSCSTPSSPGDYYSSVES----DLKVELTEKLFALDTEGNSPANTRDLSDLDLETLAPYIPMDGDFQLNII-PEAGSM-GSNDSQ--MMGHQN
PPYQAPASTPLSSMGGRQNLQWPP----------------------------------------------------------------------------
-------------------------------------------------------
>tr|K1QJG7|K1QJG7_CRAGI Hypoxia-inducible factor 1 alpha OS=Crassostrea gigas GN=CGI_10017861 PE=4 SV=1
------DDPRNGNSEKRKEKSRDAARCRRGRETEIFSELAEQIPQYSGSNGQLDKASIMRLAISYLKISQIMETQRNN---RHAPCEEFDSLYSKALDGF
VVILSNEGDLIYISESVSKYLGIQQVDLVGQSIYEFVHPCDHEDITDIFHSNGRDKKKKSEEFHHTFFVRMKCTLTNKGKNVNLKSATYKVIKFSGKLVK
DKI---KKECG-GEGNAPYLLLIGEPIPHPSNIEIPLDQMTFLSRHNMDMKFTYCDDRVKDLLGYNCSDLMNKSLFDYHHAMDSEVIDQAYKNLIAKGQV
MTRHG---------------------------------------IENPSLILSTAQQVPMLPLEVKLSTE-------------DVF----KPRPDNVKVD
EF-YFPP-G--VKMP---SMKMDETVDLTHLAPTSGDTCVPLIGDDC----------------VQFS-------PDQPMPALKEEP---DMFSARICSHS
PL-ATPPSVSPAPISPMDYTTPLTP-----SVVDAMDKFFSVETYQRN---DQATADLDMDMRAPYIPMNKDFSLLPPTSLFTIN-----SDFN------
P-----------GLFGRTESVFVPKEPRMSIRLVGSTAVASIEQPPDTF---NLQLKRPLDMNSLEKGP--------PSKKRFIQDYQETKKHSVLMPTG
VRKPQQH-QAK-P----YFPAMGHRDSLSGVIETP-DLLLQNPDLLAALELF---
>tr|A0A0B6YT30|A0A0B6YT30_9EUPU Uncharacterized protein OS=Arion vulgaris GN=ORF35837 PE=4 SV=1
------AKDKRRNTEKRKEKSRDAARCRRGKETEVFMELANCLPVPESVFSQLDKASIMRISISMLKIFNILQSDSNN---DSAKIDKFDHLYQKALEGF
AFILAQEGDIVYLSESVARYLGLQQIELVGQSVFDFTHPCDHDEIKEVLAIKQAQQQI--SSDTRNFFMRMKCTLTAKGRNANLKSATYKVLKCTGRVIT
KKGSGSQDQCQ-VQTTLHYLVGIAEPIPHPVNIEVPLDSKTFLSKHSMDMHFIFCDERIKELAGYDCEGMIGQSLYDFHHALDSEVIDKAFKDLFSKGQT
VTGSYRFLARHGGYIWVVTQATIINNSRSQKPQWVVCVHYVLSGIEDNGTILSHIQCPDLLNTKVELNTE-------------NIF----APKTKDMEQ-
-G-YMKPSE--IKGSI--MFHDKDPEDLSYLAPNAGDELIPLTFNIL----------------LSPS-------H-----ALKQEP---GTSTPDMCYRS
PASALSSNSSSRIASPNDYMSM--A-----VDVESMDKFFQIKTS---E-EDGDAEDIDFDMRAPYIPMDGDLGLLPPSSLFNLS-----SEIN------
P-----------RLFGLTESVFGPKPIKLSVRLGGSTAVASIEQPPDTM---YLQLKRPLDMNSLEKGP--------PRSKIVRLNPQDSSSSSVLLNYG
VSNMLLD-PIK-T----CLPNLTRQDCEVNAPTQA-AHLLQGQELLQALEGI---
>tr|M1K779|M1K779_HALDV Hypoxia inducible factor-1alpha OS=Haliotis diversicolor PE=2 SV=1
------SKDKKRNSDKRKEKSRDAARCRRSKETEVFYELAQNLPLPSSVSTQLDKASIMRLTISFLKICKIREEKKWH---DDDIQKRLHQMYPKALEGF
VLILSREADIVYLSENTAKFLGIQQIELMGQSIFDFTHPCDHEEIRDMMSDRPHGSKA--VSEERTLFIRMKCTLTSKGKSVNLKSATYKVIKCTGRLVV
AKKSKKD--SD-DASMYPYLLAVGEPIPHPANIEAPLDSSTFLSKHNMNMSFTYCDDRIQDLIGYNNDNLIGKSLYNYHHALDSEIVEKAFKDLFAKGQT
MTGQYRFLAKNGGYAWVITQGTIIYNNRTQKPQWVVCVHYVLSAIQEKNMILSEVQQQDLLSFKMEQSTD-------------KIF----GPRTKDMEQ-
-N-YFVPEE--LKNNI--TLVNNEPADLSYLAPTAGDGCVQLGFPDF----------------ACMD-------KDLPPPMCKEEP---DPVPRDVHRNN
SNNPSPASLSPRIQSPDEYQTIASP-----TDVDLMDKFFSMDTTQKGS-SDSDMEDVDLNMRAPYIPMNADFSLVPPSTLFSLQ-----NDFN------
P-----------GLFGRTESVFMDKPMQPSVRIGGSTVVASIEQPPDTM---LLQVKRPLDMNSLEKGP--------PVAKVVKRNDEGPSKESVLLNHG
VNSSLQ--RMH-G----FFTDLTRQDCEVNAPTQS-HHLLQGEDLRAALDAD---