>seq_1
MDTGTVPEKKRVSSDRRKEKSRDAARSRRGKESEVFYELAQELPLPHSVSSSLDKASIMRLIISYLRMRKLLSTEEPMAEEETDLDAQLNGSYLKALEGF
LMVLSEDGDMIYLTENVNKCLGLAQFDLTGYSVFDFIHPCDQEELREMLVHKTGSKKTKEPNTARSFFLRMKCTLTSRGRTVNVKSAAWKVLHCSGHVRV
YDGCTEETPNGHKEPPVPYLVLICDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLLNRSVYDYYHAMDSDHLTKTHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCIVCVNFVLSGIQEEKLVLSLEQMEDVKPVEEEEEEQQQQQQQQQEEEEEEQQQQQQQEEEEEEVKA
VVEIRELVMSPALKEVEEKGPELDVIKLFTQAAEAQPFVSLYDQLKEEPEALTLLAPAAGDAIISLDFSCPDSEIQLLKEVPLYNDVMLPSTSDKLALPL
SPLPPCEPLHVSTISSEAAKAESFPSSTFTSLRSTEAGSLMDFCFPMDSEMKSDSKLDFVEKLFAIDTDPKNLFTTQAMEDLDLEMLAPYIPMDDDFQLR
SLTPEEPLSCGPVKSLQSSPIHITQDIHSYPFSPVSAPSSRTASPALLRAPQTAPIIAMRTPQLDKEVSLRTLAAQNAQRKRKMGDIKEIIGQGTLPQEQ
VEQGKKLKASASGTTRTILLLPSDMASRLLGCTSENTSSLFSLPHLTRDDCEVNAPLQGRQCLLQGEELLCALDHVNVI
>tr|H3B2A5|H3B2A5_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=HIF3A PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------CCIFSQLELIGHSVFDFVHPCDLEELKDMLCPRQGFSKKKKVNTERSFFIRMKSTLTSRGRTVNLKSASWKVLQCTGHMKT
YTSSEH-PEDGYPDLPMTYLIMTCEPIPHPSNIEVLLDSRTFLTRHNMDMKFTYCDERITELAGYHPDELIGQSAYEYFHALDSDPLSKCIHDVLSKGQA
VTGLYRFLTREGGYMWTQTQATVIYNSKNSQPESIVCLNFVVSGIEEKDVVFSLEQRESQLKPIVKILEK------------------------------
------------------------------RQSGADTKEDLFTKLKEDPEELTQLAPTPGDTIIPLDFSLDCKEPKVFVKPPDVSDAVFSATPEKFCSPE
LPIDPE-PRSVVSFQQQGPVAEVKPGLTGLVFSDPEGW-EQGLYAIVSSGEEFNLEMENVQKLFATNKEAQDTDI-SQVRSLDLEMLAPYISMDDDFQLT
VMEAKPLKEDDALPKSCGGSMTIINQQEQLAD-EANGVKDTVETEVTTSSGTLSSPAKKRPLDLEDGLNSEALSVQNVKRRHCSGSEEPSASLGSLFDTE
A-PAEKLWVWDEVFFNTFLYFSSALVQKLLFLSSEDS----VLPDITSYECGAASPLQSSRHLIQVEDLLRVLDQTT--
>tr|A5H735|A5H735_SANLU Hypoxia-inducible factor 1 alpha OS=Sander lucioperca GN=HIF-1a PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVFDFIHPCDQDELREMLVYKTGPKKTKESNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YDSHTEETPNGHKEPPVPYLVLICDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQV
STGQYRMLAKKGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKQILSLEQIEDVRPVKEEEKA-VVESSQPNMSPTLPK---------------
---------------DEEKGPELDVIKLFTQAV--QPLTSLYDQLKEEPEALTLLAPAAGDAIISLDFSCPDSEIQLLKEVPVYNDVMLPSTSDKLALPL
YPLPPREPLHVTT-SSEDAKAKSYTSTTSTSHSSTEADSPLDFCFPMDSEMSSDFKLDLVEKLFAIDTEPKTPFNTQAMEDLDLEMLAPYIPMDDDFQLR
SLSPEEALSGGPVKSLESSPVHVTQDIHSYPSSPFSAPGSRTASPAPLNAPNPATVVAKRTPQLDKEVSLRTLAAQNAQRKRKLGDLIEIIEQGTLPQKE
VEQGKKLKASESGTTRTILLLPSDMASRLLGSTSEGTGSLFTLPQLTRYDCEVNAPLQGRQFLLQGEELLRALDHVN--
>tr|Q5IGQ2|Q5IGQ2_EPICO Hypoxia-inducible factor 1 alpha (Fragment) OS=Epinephelus coioides GN=HIF-1a PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVYDFIHPCDQEELREMLIHKIGSKKTKEPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCAGHIRV
YDNHVEDTSNGHKEPPVPYLVLICDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPDDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKMIFSLEQTEDVKPVKEEQMG-EEKVVVESSQPDMSPTLL------------
-------------KEEEEKVPELDVIRLFTQAV--QPLVSLYDQLKEEPEALTLLAPAAGDAIISLDFSCPDSEIQLLKEVPLYNDVMVSSTSDKLALPL
SPLPPSEPLDVTT-SSEVAKAESLPSTTSTSHSSSETDSSLDFCFPMDSEMSSDFKLDLVEKLFAIDTEPKTPFSTQAMDDLDLEMLAPYIPMDDDFQLR
SLTPDEPLSCGSVKSLQSSPVHVTQDIHSYPSSPFSAPSSRTASPAPLSARHPVTMVTKRTPQLDKEVSLRTLAAQNAQRKRKLDDVKEMIEQQTLPKEQ
VEKGKKLKPSESGTTRTILLLPTDVASRLLGSTAEGTSSLFTLPQLTRYDCEVN-------------------------
>tr|L7NCR4|L7NCR4_CYNSE HIF-alpha OS=Cynoglossus semilaevis PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVFDFTHPCDQEELREMLIHRSGSKKNKEQNTERSLFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YDNNTE-QTNGHKDPPVPYLILICDPIPHPSNIEAPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLLNRSVYEYYHALDSDHLNKTHHSLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQTEDVKPVKEEQEEEKAEVLSGLSDMPLTLLK-------------
-------------EEEDTKVPELDVTKVFTQSV----SSSLYDQLKGEPEALTLLAPAAGDTIISLDFSCPDSEIQLLNDAPLYNDVMLP----------
----PSEPLNITV-GSDNSKSESYPPAATTSNCSSETDSQLDFCFPMDS----DFKLDYVEKLFAIDTEPKTSFNSEIMADIDLEMLAPYIPMDDDFQLR
CLTPEEPLTGVQVKSQHSSPLHIKQDLTSYPSS----PASRTASPALPESLNLARLIGKRSPQSDKDVSLRTLVAQNTQRKRKLCDLKEIIEQGTLLEGQ
GEQGKKLKATELGSTTTILLLPSDLASRLLGSTSDGTGSLFTLPHLTRYDCEVNAPLQGRQYLLQGEELLRALDHVI--
>tr|S5YDM3|S5YDM3_SEBSC Hypoxia inducible factor-1alpha OS=Sebastes schlegelii PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVFDFIHPCDQEELREMLVYKTGSKKAKEPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YDGHTEETSSGHKEPPVPYLVLICDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYSNKNSQPQCVVCVNFVLSGIQEEKLILSLEQIEDVKPVKEEEQH-EEEKVVVESSQPKD----------------
----------------EEKGRELDVIKLFTQTV--KPLVSLYDQLKEEPEALTLLAPAAGDAIISLDFSCPDSEIQ-----PLYNDVMLPSTSEKLALPL
SPLPPSEPLHVAT-SCKDAKAEGYPSTTS---PSSEADSPMDFCFPMDSEMNSDFKLDLVEKLFAIDTEPKTPFITQAMEDLDLEMLAPYIPMDDDFQLR
SLTPDEPLSCGPVKSLESSPVHVTQDIHSFPSSPFSEPGSRTASPALLTAPQPATIVAKRTPQLHKEVSLRTLAAQNAQRKRKLGDIKDLIGQGTFPQEQ
VDQGKKLKASEAGTTRTVLLLPSDLASRLLGSTSDGTSSLLNLPQLTRYDCEVNAPVKGRQYLLQGEELLRALDHVN--
>tr|Q30HW1|Q30HW1_PACBR Hypoxia inducible factor 1 alpha OS=Pachycara brachycephalum PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLEQFDLCGHSVFDYIHPCDQEELREMLVHKTGSKKAKEPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YDT--EETPNGHQEPPVPYLVLVCDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLLNRSVYEYYHALDSDHLTKTHHNLFTKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCLNFVLSGIQEEKLILSLEQIEDVKPVKEEEQQEEEKDVVESSQPDMSQFL-------------
-------------LKDEKKGPELDVIKLFTQAV--KPLASLYDQLKAEPEALTLLALAAGEAIISLDFSCPDSEILLLKEVPLYNDVMLPSTSDKLALPL
-----SEPLRVAT-SSEDDKAKSYRCTSS--SSSSEADSPLDFCYPMDSEMSSDFKLDLVEKLFAIDTEPKTPFTTQAMEDLDLEMLAPYIPMDDDFQLR
SLTPEESLSCGPVQSLQSSPVHVIQDIHSYPSSPFSAPGSRTASPAPLTAPHPATIVAKRTPQLDKEVSLRTLAAQNSQRKRKLGDIKEIIGQETLPKEQ
VEQGKKLKASKSATTRTILLLPSDLASRLLGSTAESTGSLFTLPQLTSYDCEVNAPLQGRQSLLQGEELLCALDHVN--
>tr|T1Q054|T1Q054_9TELE Hypoxia-inducible factor 1 alpha subunit OS=Gymnocypris namensis PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------SMGPPQFDLTGHSIFEFSHPCDHEELREMLVHRTGSKKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCAGHVRV
QERGEDSGDSGFKEPPLTYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGYEPDDLLNKSVYEYYHALDSDHLTKTHHNLFAKGQA
TTGQYRMLAKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDVVLSLQQTVTEPKAEEKENQAFEDEASEV----------------------
-----------------------DILKLFKLKSCPMKNLDLYEKLKEDSEALTVLAPAAGDTIISLDFNN-DSDMQLLKEVPLYNDVMLPSGSEKLSISL
SPLTPSGSTPVLTFSSASDLGPDSPSTSGLGS--SGPNSPVNYCFQVDSDISSEFKLDLVEKMFANDTEAKTPFSSQAMEDLDPEMLAPYIPMDDDFQLH
-PSPLDPLPSGPHSSRAPSPLHLLQEVCNAPVSPFSGT--RDVSPAR--IPQSSNQLNN------RELSPKMLAIQNAQRKRKLEEVTEAVGLSALLQSA
IEPGKRAKVFLLGGNKTILILPSDVASRLLCSSLENSS---GLPQLTRYDCEVNAPVQDRHHLLQGEDLLRALDQVN--
>tr|A5H737|A5H737_PLAFE Hypoxia-inducible factor 1 alpha OS=Platichthys flesus GN=HIF-1a PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVFDFTHPCDQEELREMLIHKTGSKKTKESNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YDTKTEETSNGLKEAPVPYLVLICDPVPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERITELMGYDPEDLLNRSVYEYYHAMDSDHLTKSHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATDIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQTEDEILVKKEQKRQEKEEKVVVESILPDMSTTLLKEEDEEVE--
---EVEVEEQVEVEEAAEKGPELDVIKLFTQAS--QPLASLYDQLKEKPEALTLLAPAAGDTIISLDFSCPDSEMQLLKDAPLYNDVMLPSSSEKLALPL
SPLPPSEPLNTRG-KSEESKAESYPSTTITCQRSSEADSPMDYCFPMDSDMSSDFKLDLVEKLFAIDTEPKTPFNTQAMEDLDLEMLAPYIPMDDDFQLR
SLTLDEPLTSGQVKSLKSSPVQVTQQVDSYPSSPFSGVGSSTSSPAPLEVAHLATIIAKRTPQLDKEVSLRTLAAQNAQRKRKLGELKDMFGQGNLLEEQ
LVQGKKLKAAESGTTTTTFLLSSDLASCLLGSTSDVTRP-LYLPQLTRYDCEVNAPLPGRQFLLQGEELLRALDHVN--
>tr|W5LPR6|W5LPR6_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLPQIDLSGQSVFDLTHPCDHEEIREMLVHRTGSSKIKEPNTERRFLLRMKCTLTSRGRNVNIRSASWKVLHCSGHIRA
PVRVCVQDDCEDRGVPASYLVLICNPIPHPASIEKPLDSRTFLSRHTLNMHFTYCDDRIKELLGYDPKDLLQQSVYEYYHALDSDSLTKTHHNLFAKGQA
CTGQYRMLVKTGGFVWMETQATVIYNSKNSQPQCVVCVNYVLSGVEDPELVLSLHQSGSMVVKQEKKEEEEEEKKEEEEE--------------------
---------------------EREKQECFQK----IETAVLQDDLKEEPEVLNQLHFSSAACSASFTLKNRDIDAAVLKDVPLYNDVMLPSSSVLLPLSP
LLPPPCASLPDTTFPLSSDTDTS-STAGDTTTCSTQPTSP------LTSDHSYQCKMNSEEEIFSIETETKTLLDAQAVKDLDLEMLAPYIPMDDDYQLR
VH---Q---SGCVSADPPPPAQPLQSSSFYAFQCFTGFQDTNVSEL--E----TLQISSKTDSF--QVHGNMLALQQKLLKRKLE-TIQAVGLGSVVQVI
PTAGKKVRRSALPETVTILLLPSDVVAQLLAGPSEGRTLPVPLPQLTRYDCEVNVPVAGRQNLLQGEELLYALD-----
>tr|G4WI71|G4WI71_MYXAS Hypoxia-inducible factor 1a OS=Myxocyprinus asiaticus GN=HIF-1a PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------SMGLTQFDLTGHSIFEFSHPCDHEELREMLVHRMGSKKNKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRV
QERSEESGDCGFKEPPQAYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGHEPDDLLNKSVYEYYHALDSDHLTKTHHDLFAKGQA
TTGQYRMLAKKGGYVWVETQATVIYNPKNSQPQCIVCVNYVLCDIVEGNIVLSLQQTMTEPKAVVKESQEMEDEPSEV----------------------
-----------------------DVLKLFRPEGCKESSSSLYEKLKEQPEALAGLAPAAGDTIISLDFNN-DSDVQLLKEVPLYNDVMLPSSSEKLPMTL
SCLTTSESIPPLTFSSDSQRVPD-PSTPGLGS--SGPNCPMDYCFQVDSDISSEFKLDLVEKLFAIDTEAKTPFTTQDMEDLDLEMLAPYIPMDDDFQLH
IPSPLEQLPSGLNSSRAPSPLHLLQKVCSAPVSHFSSS--REASPAR--TPQGGNQLNNRMPMGDRELSPKMQAIQNAQRKRKLEEVTEAVGLGALLQSA
IESGKRAKILVLGGNKTILILPSDVASRLLSSSLESSG---GLPQLTSYDCEVNAPVQDRHHLLQGNELLRALDQVN--
>tr|W5LJA8|W5LJA8_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFDLTGHSVFDFAHPCDHEEMREMLVHRTGSKKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRV
QESGEGSADSSFREPPITYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGHEPDDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQA
TTGQYRMLAKKGGYVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDMILSLEQTVTEPKAVEKEEKQKDKEEETE----------------------
-----------------------VDMDSFKQEKSVESLESLYEKLK-EPEALTVLAPAAGDTIISLDFNS-ESEMQLLKEVPLYNDVMLPSTSEKLPLPL
SPLAPSEPPPALDFPSTSHRSADAPSTPSTGSSTSAPNSPIDYCFQVDSDIGSEFKLDLVEKLFAIDTEAKTPYSTQDMGDLDLEMLAPYIPMDDDFQLL
IPSPLDPLPSGPHTSRVPSPLHMLQEVRSAPVSPFSGNRSREASPAR--TPQGSRTLTTGMSAVDRELSPKVLAIQNAQRKRKLEEVTQAVGLGALLQSA
IEPGKRAKVLLLGGNKTILILPSDVASRLLCSSFESSG---GLPRLTRYDCEVNAPVQDRHPLLQGEELLRALDQVN--
>tr|V9P247|V9P247_CLABA Hypoxia induced factor 1 alpha OS=Clarias batrachus GN=HIF-1 alpha PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFDLIGHSIFDFAHPCDLEEVREMMVHRPGSKKTKVQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRV
QEHSDGSGEGGFKEPSVTYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGHEPDDLLNRSVYEYYHALDSDHLNKTHHNLFAKGQA
TTGQYRMLAKKAGYVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEEDTVLSLQQTLPEKTEEKEEELQIEHEDSSV----------------------
----------------------MDMMKLFKKDHSVESPKSLYDTLKDEPEALTVLAPAPGDTFVSLDFDS-DSDLQVLKEVPLYNDVMLPSTSEKLPLPL
SPLAPSDPSPALVISSTSRLTPDTPPSSTSS---SEASSPSH-YFHVDSDI--NFKLDLVEKMFATDTESNSDFNTDEMGDLDLEMLAPYIPMDDDFQLH
IPSSLNPLPSGPQTSHVPSPLHLLQELSSIFGTPFN-----EASQTL--SPEPGIPLAKRMQVDDDEFASKVLTVQNGQRKRKLE-ITQAVGLDALLQSV
GEPGKRAKVLLLGGNKTILILPSDLASRLLSSSFESSG---GLPQLTRYDCEVNAPIQDRHPLLQGEELLRALDQVN--
>tr|W5UA58|W5UA58_ICTPU Hypoxia-inducible factor 1-alpha OS=Ictalurus punctatus GN=HIF1A PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFDLTGHSIFDFTHPCDHEEVREMLVHRTGSKKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRV
QEHSESSGGVGFKEPSITYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGYEPDELLNRSVYEYYHALDSDHLSKTHHNLFAKGQV
TTGQYRMLAKKAGYVWVETQATVIYNPKNSQPQCVVCVNYVLSGIVEEDMVLSLQQTVPEKTVEKEEELQVEQEDKSV----------------------
----------------------MDMMKLFKKDPSVESPKSLYEKLKDKPEALTVLAPAAGDTIISLDFDS-DSEIHVLKEVPLYNDVMLPSTSEKLPLPM
SPLAPSDPSPDLVFSSTSHHVSDTPSISASS---SEPSSPAD-YFHVDSDIGSEFKLDLVEKMFATDTEADTHFNTDEMCDLDLEMLAPYIPMDDDFQLH
IPSPLDPLSSGPQTPHVPSPLHLLQEVSSIFVTSFD-----EASGAH--TPQTGK-AAKRMQVEDQDLSTKSLN---VQRKRKLE-ITQAVGLDVLLQSA
VEPGKRAKVLLLGGNKTILILPSDVASRLLSSSFESRG---GLPQLTRYDCEVNAPIQDRQSLLQGEELLRALDQVN--
>tr|T1Q049|T1Q049_9ACTI Hypoxia-inducible factor 1 alpha subunit OS=Lepisosteus platostomus PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFDLTGHSVFDFTHPCDHEEMREMLTYRTGSLKKAKQNSERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIQV
YESSDGHNNCGYKEPPMTYLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYQPEDLLGRSVYEYYHALDSDHLTKTHHDLFAKGQA
TTGQYRMLAKKGGFVWVETQATVIYNTKNSQPQCIVCVNYVLSGVVQEDLVFSLGQTESV-LKPLE----SPDVEM------------------------
-------------------------PKIFTKAEDLESSNTLFEKLKEEPEALTLLAPAAGDTIISLDFTS-DSEIQPLEEVPLYNDVMLPSSSEKLPLSP
LPPDPALNVEVVSFSFSIPRTQDSPSGTSTRQNSPEPSSPGDYCFQVDSDIGSEFKLDLVEKLFAIDTEAKTPFATQTMDDLDLEMLAPYIPMDDDFQLR
TLSPSETLSASAPVARAASPLHLVQEVRNALNSPFSGSRSRTSSPAPSSTSSAT-SPSRRIPALEGALSPKMLAIQNAQRKRKLETGTQAVGIGTLLHEP
AAIEKRAKVFAL-THKTILLLPTDLASRLLECSFG-SD---GLPQLTRYDCEVNAPVQGRQHLLQGEELLRALDQVN--
>tr|A0A0P7YFP3|A0A0P7YFP3_9TELE Hypoxia-inducible factor 1 alpha subunit-like OS=Scleropages formosus GN=Z043_116106 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------CLGLAQFDLTGHSVFDFTHPCDHEELREMLVHRTGPSKKAKKNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCTGHVRV
YENIEGESHCGYKEPPVPYLVLICEPIPHPANIEVPLDSKTFLSRHTLDMKFSYCDERVTELMGYEPEDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQA
TTGQYRMLAKKGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSNIVEEKLVLSLEQTEKDVKGDVKEDVEDVNEDTEELKFSE-----------------
-----------------PTGLEADMIKLFTKAE--ECADSLYDKLKEEPDGLTMLAPAAGDTIIHLDFSC-DPEQPLLKEVALYNDVMLPSTSVKPPLPP
SEPDPPLSTKVRAFSMVRT--ADSTPGPSAGRASPQPDSPLDFCFQVDSDIGSEFKLNLVEKLFAIDTEPKTPFT-QAMEDLDLEMLAPYIPMDDDFQLH
VLSPAESLAST---RHAASPLHLLQEVQSAPCSPFSGSCSRTSSPAPPDIPRCATPVGKRITGADVELSPKMLALHNAQRKRKLEGEAQALGLGALLEGT
VNKGKRARVLGL-SHKTMLFLPSDLASRLIGGSVD-GN---SLPQLTRYDCEVNAPVLDRQHLLQGEELLRALDQVN--
>tr|A5H729|A5H729_ACIGU Hypoxia-inducible factor 1 alpha OS=Acipenser gueldenstaedtii GN=HIF-1a PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFELTGHSLFDFAHPCDHEELREMLTHRTGSTKKGKHNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
CDPSKGENNCGYKERPMTSMVLICDPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYQPEDLLGRSVYEYYHALDSDHLTKTHHDLFAKGQA
ITGQYRMLAKKGGFVWVETQATVIYNTKNSQPQCIVCVNYVLSGVVGEDLVFSLGQTENV-LKPVE----SPDADI------------------------
-------------------------TKLLMQVDPEENTNSLFEKLKEEPEALTLLAPAAGDTIISLDFSKDNSEIKKLEEVPLYNDVMLPSSSEKMLMSP
LPPDPVLNVEVVTISFTIPQTPDL--LPSATQSLPEPSSPSDYCFKVETDFSGEFKMDLVEKLFAIDTEARTPFTTQVADDFDLEMLAPYIPMDDDFQLR
TLSSIEPISASPPDMSIVSPLHMTEEVKSAPNSPFSGKNSRTSSPIRKSLVPGTPLRSKRPTAFDEELSPK----MLAQRKRKLESGLKAVGIGTQLHQ-
--TLKRSKASVL-THKTILLLPTDLASRLLACSFE-NS---GLPQLTRYDCEVNAPVQGKQTLLQGEDLIRALDQVS--
>tr|T1Q067|T1Q067_POLSE Hypoxia-inducible factor 1 alpha subunit OS=Polypterus senegalus PE=2 SV=1
----------------------------------------------------------------------------------------------------
-------------------CMGLTQFELTGHSVFDFTHPCDHEELREVLTHRAGAAKKGKVNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCLGHIRA
YESCE-ENDCGYKKPLVTSLVVICEPIPHPSNIEVPLDSKTFLSRHSLEMKFSYCDERITELMGYQPEDLLGRSVYEYYHAMDSDHLTKTHHNLFAKGQA
TTGQYRMLAKNGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSGVVEKDLIFSLSQTETLPVKAIE----DPELET------------------------
-------------------------VKVTGKTVPEGDGDSLFDKLKEEPEALTVLAPAAGDTIISLDFST-ESEMSSFEEVPLYNDVMLPSPNEKMLMSP
VSSDPALNLEVAVLSFSIPQIHNSSSLQSSTQSSPGPNSPVDYSFEVDSDISSEFKLDLVEKLFAIDTEAKTSFVSQAGDDLDLEMLAPYIPMDDDFQLR
TMSPMESLPSNPLILRTVSPLHMIHNVQSLSDSSFSIQTNEAASLLNNSAESIQTLLGKTICTLDEELSPR----TCAQRKRKLQIADKALEIGSVLPVS
VGAWKRAKACAP-KHKTIILLPTDLASRLLASSFE-SS---GLPQLTRYDCEVNAPLQGRQNLLQGEELLRALDQVN--
>tr|S7N5Y1|S7N5Y1_MYOBR Hypoxia-inducible factor 1-alpha OS=Myotis brandtii GN=D623_10027172 PE=4 SV=1
----SSDGSTRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDI--EDEMKAQMNCFYLKALDGF
VMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHV
YDTNGNQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNFVVSGIIQHDLIFSLQQTECVLKPVESSDMK------------------------------
------------------------MTQLFTKVE-SEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNETDDQQLEEVPLYNDVMLPSSNEKLQLAM
SPLPASETPEPALLSFTMPQIQASPSDGSTRQSSPEPTSPSEYCFDVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDT-DLDLEMLAPYIPMDDDFQLR
SFDQLSPLESSSTVTASPSPTHVPKETSSTTTSPYSDNRSRTASPNRAKGVHLSITLSQRTTVPEEELNPKILALQNAQRKRKIEHDGQAVGIAGQWLGR
GPGMERVQAGLRGPMHEFQHRASNLACRLLGQSMDES----GLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN--
>tr|Q6EHI4|Q6EHI4_DANRE Hypoxia inducible factor 1 alpha OS=Danio rerio GN=hif1ab PE=2 SV=1
----VTEK-KRVSSERRKEKSRDAARSRRGKESEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLLNSDEKE-EEENELESQLNGFYLKALEGF
LMVLSEDGDMVYLSENVSKSMGLTQFDLTGHSIFEFSHPCDHEELREMLVHRT-GSKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCAGHVRV
HEGSEASEDSGFKEPPVTYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERT-ELMGYEPDDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQA
TTGQYRMLAKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDVVLSLQQTVTEPKAVEK----------------------------------
---------------------------LFKPESLNCESSTLYNKLKEEPEALTVLAPAAGDAIISLDFNNS--DIQLLKEVPLYNDVMLPSSSEKLPLSL
SPLTPSDSIPA--FPFSSASDRPTPST---------PNSPMDYGFPVEPDISSEFKLDLVEKLFAIDTEAKTPFSTQPMEDLDLEMLAPYIPMDDDFQLR
PS-PLDPLP----SS-------LLQEVCSAPVSPFSG--SRDASPVRSSS----------SQLNNREMSPKMLAFQ-IQRKRKLNEVT---GLGLLH-DA
IDPGKRAKVLEVKGNKTILILPSDVASRLLSSSLEG-----GLPQLTRYDCEVNAPVQDRHHLLQGEELLRALDQVN--
>tr|F7G7B7|F7G7B7_ORNAN Uncharacterized protein OS=Ornithorhynchus anatinus GN=HIF1A PE=4 SV=2
----------------------------------------------------------MRLTISYLRMRKLLDTGDLEA--EAEMEAQLNCFYLKALDGF
VMVLTEDGDMIFMSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTHRNGSVKGREQNTERSFFLRMKCTLTSRGRTVNIKSAAWKVLHCTGHIRV
YDACSNQAQCGYKKPPMTCLVLICEPILHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVQKDLIFSLGQTECVLKPVESPDMK------------------------------
------------------------MTQIFSKAD-PEDTSSLFDKLKKEPDALTLLAPAAGDTIIYLDFGNN-EEQQLLDEVPLYNDVMLPSSSEKLQLAL
SPLPATEPDKPVTLTFTVPQLQASPSDASTDQSSPEPSSPSEYCFNVDNDMASEFKLELVEKLFAEDTEAKNPFSAQDT-DLDLEMLAPYIPMDDDFQLR
SFDQLSPIETGSAIAVSPSPGHT-ETTGAPA-SPYGGARSRTASPARAKGVHLSVTLSKRTTALDEELNPKMLALQNAQRKRKMEQDSQVVGIGSLLQQT
SLSWKRVKGCKSSEQKTVVLLSSDLASRLLGQSMDES----GLPQLTSYDCEVNAPIQGNRNLLQGEELLRALDQVN--
>tr|V8NR02|V8NR02_OPHHA Hypoxia-inducible factor 1-alpha OS=Ophiophagus hannah GN=HIF1A PE=4 SV=1
----GSCEKKRISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHHVSAHLDKASVMRLTISYLRMRKLLDADDLEA--EAEMETQLNCFYLKALDGF
VMVLSEDGDMIYTSENVNKCMGLTQFELTGHR----------------------SVKGKDQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
YENCNNQNVCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELIGYDHEELLGHSVYEYYHALDSDHLTKTHHDMFAKGQV
TTGQYRMLAKQGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVQGDLVFSLQQTERMLKPVDSPEMG------------------------------
------------------------MMKVLNKSD-VEDSSSLFEKLKKEPDALAYLAPAAGDTIIALDFDNDEPDEQPSDDVPLYNDVMLPSSSEKLQLAM
SPLSASETAKTVALTFSSRRTQATPSDGSTSQSSPENSPPNDYCFSMDNEISSEFKLELVEKLFAIDPESKNPFSMQET-DLDLEMLAPYIPMDDDFQLR
TFDQLSPLEGNTAVTINPKVLPPAPIISAPT-SPYAKNESRTSSPIRTKGTSLTVTFG-RSPEVNEDISPRIIALHNIQRKRKMEQDGQAVGIGTLLAQI
SLAWKRVKGCRSNAEKTVILLPSDIASKLLGQSMDEK----GLPQLTSYDCEVNAPIQGNRNLLQGEELFRALDQIN--
>sp|Q9I8A9|HIF1A_XENLA Hypoxia-inducible factor 1-alpha OS=Xenopus laevis GN=hif1a PE=2 SV=1
----VVSEKKRISSERRKEKSRDAARCRRSNESEVFYELSHELPLPHNVSSHLDKASIMRLDHQLPAVEKVADAGDLDG--ETELDKQLNCFYLKALEGF
VLVLTEEGDMIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTFRNGPAKRKRTNHREKFLPSYEMYINQS-----WKNREYKVSHYRTHACI
YDNANNQNHCGYKKPPMTCMVVICEPIPHPSNIEFPLDSKTFLSRHSLDMKFSYCDERVTELVGYEPDELLGRSVYEYYHALDSDHLTKPNYNMFTKGQV
TTGQYRMLAKKGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSEVVEKDLILSLGQTASVLIPVESQEIK------------------------------
------------------------MPEIFTELNEENNSECLFDKLKQEPESLTVLAPDAGDEIIPLDFSSGDS-DKPYEDVPLYNDVMLHSTSNKLE-PI
TPLPAPEMPKPVIASIHHSTAIRQPFRYQFQSEPS-EPNTPEYCFDVDSEMASEFKLDLVEKLFAIDTEAKAPFYYPGN-DLDLEMLAPYIPMDDDFQLR
TFDQLSSLECDSSTT--QSPVHMKESTSAPV-SPYNGNRSRTSSPVRPKAVRPVP---KRCTILDEELNPKMICFTQCTEKRKMESDGQAIGIGTLFQTS
SLQWKRVKGSDSEEQRTILLLSTDMASQLLGQSFDGT----VLPQLTGYDCEVNAPVHGTRNLLQGEELLRALDQAN--
>tr|A5X382|A5X382_XENLA Hypoxia inducible factor 1 alpha OS=Xenopus laevis GN=HIF1a PE=2 SV=1
----VVSEKKRISSERRKEKSRDAARCRRSKESEVFYELSHELPLPHNVSSHLDKASIMRLAISYLRLRRLLDAGDLDG--ETDLDKQLNCFYLKALEGF
VLVLTEEGDMIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTFRNGPAKGKEQITERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHMRV
YDNANNQKHCGYKKPPMKCMVVICEPIPHPSNIEFPLDSKTFLSRHSLDMKFSYCDERVTELVGYDPDELLGRSVYEYYHALDSDHLTKAHHNMFTKGQV
TTGQYRMLAKKGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSEVVEKDLILSLGQTACVLIPAESQEMK------------------------------
------------------------MPEIFTDLSEENNDECLFDKLKQEPESLTALAPDAGDDIIPLDFSSGDS-DKPYEDVPLYNDVMLHSTSKKLE-PV
TPLPASEMLKPVILAFTIPQLSGSPSDIGSSQSST-PSSPPEYCFNVDGEIASEFKLDLVEKLFAIDTEVKAPFTTQET-DLDLEMLAPYIPMDDDFQLR
TFDQLSSLECDSSSA--QSPVHMKESTSAPA-SPYNGNRSRTSSPVRPKAVRPVQ---KRCPVLDEELNPKMIALHNV-RKRKMESDGQAIGIGSLFQTS
SLLWKRVKGSDSDEQRTMLLLSTDMSSQLIRQSLDGT----GLPQLTGYDCEVNAPVHGNRNLLQGEDLLRALDQAN--
>tr|B3FMV7|B3FMV7_RANTE Hypoxia-inducible factor 1 alpha OS=Rana temporaria GN=HIF-1a PE=2 SV=1
----VTD---KKSSERRKEKSRDAARCRRSKESEVFYELSHQLPLPHNVSSHLDKASIMRLTISYLRIRRLLDAGDMDG--ESEMEKQLNCFYLKALEGF
VLVLTEEGDMIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTFRNGPSKGKEQITERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHMRV
YDGCNSQNHCGYKKPPMTCMVLICEPIPHPSNIEFPLDSKTFLSRHSLDMKFSYCDERVTELAGYEPDELLGQSVYDYYHALDSDHLTKAHHDMFTKGQV
TTGQYRMLAKKGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSDIVEKELILSLGQTESTLVSSEPAESK------------------------------
------------------------MPQFFTKLADEEDANVLYEQLKKAPEFLNVLAPDAGDEIIPLDFSSSDS-ESQYDDAPLYNDVMLHSTSKPPE-LV
SPLPVPEKPKPVILAFTIPQLSSSPSEISSNQSST-PGTPAEYCFDEDINVAPEFKMDLVEKLFAMDTEAKAPFSTQET-DLDLEMLAPYIPMDDDFQLR
SFDQLSSMETDSATN-VHPPTPNKEALSAPA-SPYNGNRSRTSSPVRTKAARTSP---KRPAVLDDELSPKMIALHNV-RKRKIESDGQAVGLGTIFQTS
PLLWKCVKVSDSDEQRTILLLSTDMASRLLGQSLDGT----GLPQLTGYDCEVNAPIQGNRNLLQGEDLLKALDQAN--
>tr|T1Q069|T1Q069_PROAN Hypoxia-inducible factor 1 alpha subunit OS=Protopterus annectens PE=2 SV=1
----TICDKKRISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHNISSHLDKASIMRLVISYLRMRALLSTSNIED---DESDKQLNSFYLKALDGF
VMVLTEDGDMIYLSENVNRCIGLTQFELTGHSVFDFMHPCDHEELREMLTHRIGPVKGKGQSTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCSGHIRV
YESGSDQTHCGFKEPPLTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYDPEDLLNHSVYEYYHALDSDNLTKTHHDLFTKGQV
TTGQYRMLAKEGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVEKGLIFSVEQTKSLMKSVPALDAD------------------------------
------------------------KTKHLS----TENPGHLFEKLKEEPEALTLLAPAPGDTIIPLDFNNTDTDAQSLDSVALYDDVMLSSDEKV--MDK
SPLPASEAAKPVTLSFTVAQTQNSPSDPSASQNST-PSSPSDYCFRVESDIDNEFKLDLVEKLFAVDTEAKNPFSAQVE-GLDLEMLAPYISMDDDYQLR
SFDQLPPLESDSVTPSPQSPIRIREISSAPT-SPYSASRSRTSSPVRTKGPRSPVLQ-HRAASSDQELSPKMLALQNVQRKRKMENEGTAAGIGALFQCN
SSTRKRVKGYESSEQMTLLLSSTDLASRLLGQSVESS----KLPQLTSYDCEVNAPIQGNKNLLQGEDLLKALDQVN--
>tr|H3BFX9|H3BFX9_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=HIF1A PE=4 SV=1
----IVTDKKRVSSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLLGAGEFEA--EADLDKQLNSCYLKALDGF
VMVLTEDGDIIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTHRNSPVKSKEQHTERNFFLRMKCTLTSRGRTVNIKSATWKVLQCTGHIQV
YETCKGKTHCGYQEPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELIGYQPEELLGRSVYVLYYALDSDHLTKTHHDLFTKGQA
TSGQYRMLAKEGGYVWVETQATVIYNTKNSQPQCVVCVNYVLSGVVEKELVFSIGQAKKTVESVESPDAK------------------------------
------------------------ITQLFSKIKPAEDSNSLFDQLKEEPEALTLLAPAAGDTIISLDFSKSDSEVQQFDEVPLYNDVMLPSSSENLQLEM
SPLPASETTEAVTLSFSVPQTQSTPSEHHTSQSTP-PKSPPDYCFEVDDDIVSEFKLDLVEKLFAIDTEPKSFFSTQEAEELDLEMLAPYIPMDDDFQLR
SFDQLSPLQSGSETN-TVKSIQPSHINSAPA-SPYSGNRSRTASPVRTSGLCSPVTLN-RTITLNKELNPLTILLHNVQRKRKLENEAQAVGIETLF-D-
-AGCKRTKGIQSSQQKTLILLSTDLASRLLERSED-N----RLPQLTRYDCEVNAPIQDSRNLLQGEELLRALDQIN--
>tr|G1NLD8|G1NLD8_MELGA Uncharacterized protein (Fragment) OS=Meleagris gallopavo GN=HIF1A PE=4 SV=1
-----QDAFKRISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHTVSAHLDKASIMRLTISYLRMRKLLDAGELET--EAKMEKELNCFYLKALDGF
VMVLSEDGDMIYMSENVNKCMGLTQFDLTGHSVFDFTHPCDHEELREMLTHRNGPVKGKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
YDTCNNQTHCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKQGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVQKDLIFSLGQTECMLKPVESPEMK------------------------------
------------------------MTKIFNKDD-LDDTNSLFEKLKQEPDALTVLAPAAGDTIISLDFSSNESDEQQCDEVPLYNDVMLPSSSEKLQMAM
SPLPASETTKPVSLSFTMPQVQTSPSDASTSQSSP-PSSPNDYCFDVDNDMANEFKLELVEKLFAIDTEAKNPFSTQET-DLDLEMLAPYIPMDDDFQLR
SFDQLSPLESSS-ITVPSSPVHINDTSSAPA-SPYSGNRSRTASPIRAKGTCITVTLNKRSTAMDEELNPKMLALHNAQRKRKMEHDGQAVGIGSLFQQA
SLAWKRVKACKTNEQKTIILLSTDIASKLLGQSMDES----GLPQLTSYDCEVNAPIQGNRNLLQGEELLRALDQVN--
>tr|K7FUF4|K7FUF4_PELSI Uncharacterized protein OS=Pelodiscus sinensis GN=HIF1A PE=4 SV=1
----VTPLRYRISSDRRKEKSRDAARCRRSKESEVFYELAHQLPLPHTVSAHLDKASIMRLTISYLRMRKLLDSSDLET--EAKMEKEMNCFYLKALDGF
VMVLSEDGDMIYMSENVNKCMGLTQFELTGHSVFDFTHPCDHEELKEMLTHRNGLVKGKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRV
YDTCNNQTHCGYKKPPMTCLVLICVPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFAKGQV
TTGQYRMLAKHGGYVWVETQATVIYSTKNSQPQCIVCVNYVLSEIVQEELFFSLGQTERVLKPVESVDMN------------------------------
------------------------MTKIFSKAD-LEDSNSLFEKLKKEPDALTLLAPAPGDTIVSLDFDSNESDEQQFDEVPLYNDVMLPSSSEKLQLAI
SPLPASETTKPVSLAFSSRPRQSSPSDTSTNQSSP-PHSPNDYCFDVDNDMANEFKLELVEKLFAIDTEAKNPFSTQET-DLDLEMLAPYIPMDDDFQLR
SFDQPPPLESGCASTVSQSPVLINEIDSTPA-SPYGGNRSRTASPIRAKGTYLTVTLSNRSNPVDEELNPKMLALHNSQRKRKMEYDGQAVGIGSLFQQA
S-LWKRVKGCKSNGQKTIILLSTDIASKLLGQSMDET----GLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN--
>tr|G1KSA4|G1KSA4_ANOCA Uncharacterized protein (Fragment) OS=Anolis carolinensis GN=HIF1A PE=4 SV=1
----GRRTKGRISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHHVSSHLDKASIMRLTISYLRMRKLLDAGDLEA--EAEMETQLNCFYLKALDGF
VMVLSEDGDMIYMSENVNKCMGLTQFDLTGHSVFDFTHPCDHEELREMLTHRNGPVKGKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
YDNCNNQTVCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELIGYDPEELLGRSIYEYYHALDSDHLTKTHHDMFAKGQV
TTGQYRMLAKQGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGVVQGDLIFSLQQTECMLKPVESPEMG------------------------------
------------------------VIKILDQTE-LEDSNSLFEKLKKEPDALTYLAPAAGDTIIALDFDSDETDEQQFDEVPLYNDVMLPSSSEKLQLAM
SPLPASEATKLVSLSFSIRQTQATPSDGSTSQSSPESSTPSDYCFDVDNEMASEFKLELVEKLFAIDPESKKPFSMQET-DLDLEMLAPYIPMDDDFQLR
SFDQLSPLESSSAVA------HPLETNSVPA-SPYTDNSSRTASPVRTKGTSLTVTLGSRSTAANEDINPKIIALHNIQRKRKMEQDGQAVGIGTLLAQV
SLAWKRVKGCKPNAEKTVILLPSDIASKLLGQSMDEK----GLPQLTSYDCEVNAPIQGNRNLLQGEELLKALDQVN--
>tr|F6RGY6|F6RGY6_MONDO Uncharacterized protein OS=Monodelphis domestica GN=HIF1A PE=4 SV=1
----GTNDKKKISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRMRKLLDAGDLEA--EAEMEAQLNCFYLKALDGF
VMVLTEDGDMIYMSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLIHRNGPVKGKEQNTERSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIRV
YDTCNNQSQCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIVQHDLIFSLGQTECMLKPVEAVDRK------------------------------
------------------------ITELLTNVE-TEDTSSLFEKLKKEPDALTLLAPAAGDTIISLDFDNNETDE-QQLEVPLYNDVMLPSSSEKLQLAM
SPLPATETTKPALLSFTMPQIQASPSDASTRQSSP-PSSSSEYCFDVDNDMANEFKLELVEKLFAEDTEAKNPFSTQDT-DLDLEMLAPYIPMDDDFQLR
SFDQLSPLENTSTLNASPYSVYINETASAPA-SPYDGNRSRTASPDRAKGVHLSVTLSYGTTALDEELNPKILALQNSQRKRKMEHEGQAVGIGSLHQQI
SLSWKRVKGCKSNEQKTVILIPSDLVSRLLGPSMDES----GLPQLTSYDCEVNVPIQGNRNLLQGEELQRALDQVN--
>tr|G3SJ03|G3SJ03_GORGO Uncharacterized protein (Fragment) OS=Gorilla gorilla gorilla GN=HIF1A PE=4 SV=1
----IDKSPCRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDI--EDEMKAQMNCFYLKALDGF
VMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHV
YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMK------------------------------
------------------------MTQLFTKVE-SEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNETDDQQLEEVPLYNDVMLPSPNEKLQLAM
SPLPTAETPKPALLSFTMPQIQPSPSDGSTRQSSPE------YKFDSNTYLNH--KLHLCVCL---------NFSTLK----LLQELLPNLDLSTCFRLK
NWSRLFPIAHSKLIDYRGWDIQSEQLFSCTCQSQSVTTHQVTLKPKKTKLLCLSACIS---------IVP-TISLHCYIFSVKLSFDGWGKSVGTLLQQT
SLSWKRVKGCKSSEQKTIILIPSDLACRLLGQSMDES----GLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN--
>tr|V9KA26|V9KA26_CALMI Hypoxia-inducible factor 1 alpha OS=Callorhinchus milii PE=2 SV=1
----VNPEKKRVSSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHSVSSHLDKASIMRLTISYLRMRKLLSPRDVEV--EPDREKQLNSFYLKALEGF
VLVLTQDGDMIYMSENVNKYMGLTQFELIGHSIFDFTHPCDHEEMREMLSHRQGLQKGKDQITERSFFLRMKCTLTSRGRTVNIKSSSWKVLHCTGHIQV
HEGSDEQTPCGYKEPPMTCLALVCEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYQPDELLGRSVYEYYHAMDSDHLTKTHHDLFSKGQA
TTCQYRMLSKEGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGVVEKGVVFSLDQTESVPVTDESPDTI------------------------------
------------------------ETTGKSYNS-PTESNDLFNKLKEEPEALTQLAPAAGDTIISLDFSPS--DS-EMQHFPLYNDVMLPSSTEQ-K--L
SPLPPSDPTKSITLSFTIPQMKNSPSCPSTNQSSP-PSSPSEYCYNVDTDMSNVFKLDIVEKLFAVDPEAKNPFSVQDVDGLDLEMLAPYIPMDDDFQLR
SLDQLSPLTDIQAVNSSPSPLHMDEVSSTPG-SPYSKPTSRTASPVRTGLLRPVKP--KRGGNLQEEVDAKLLSLHNLQRKRKIENAAQAAGIGLLSQNA
PQIWKRAKRSDTTKEKTLASLPTDTVSRLLMHSSETR----KLPTLTSYDCEVNAPIQNNRNLLQGEDVLRALDQVN--
>tr|B7SCS8|B7SCS8_9CHON Hypoxia-inducible factor 1 alpha OS=Hemiscyllium ocellatum GN=HIF-1a PE=2 SV=1
----GTEKKCSGSSERRKEKSRDAARFRRGKESEVFYELARELPLPHSVTSHLDKASIMRLTISYLRMRKLLNAGDMEV--EADLEEQLNSFYLKALEGF
VMVLTQDGDMIYMSENVNKCMGLTQFELIGHSVFDFTHPCDHEEMREMLSHRQGLLKGKDQNTERNFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
YKSSNEQTHCGYKEPPMTCLILICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYQAEELLGRSVYEFYHALDSDHLTKTHHDLFTKGQA
TTGQYRMLGKEGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSGLVEKEVILSLDQIECVPVE--KPEEP------------------------------
---------------------------SKHPVS-STETNNLFDKLKEEPEALTQLAPAAGDTVVSLDFNPS--EMQQFNEVPLYNDVMLPSSTNQ-KMAL
SPLPPSDAKKPIIFSFAIPQMNSSSSCPCSSQNSP-PSSPSDYCFNVDTDISNEFKLDIVEKLFAIDPEAKHPFSVQDIDNLDLEMLAPYIPMDDDFQLR
SLDQLSPFSDCQTVDPLSTP--TIKRDNGPS-SSQNKKSNRTTSPVRTGLLRPVKA--KRGEAPKEELSPQLLILHNSPRKRKLENAAQAVGIGLLFQST
SQTWKRAKGLEDSEQKTLVLVPTDIVSRLLTHSAESS----SLPTLTNYDCEVNAPIQGNRTLLQGEEVLRALDQIN--
>tr|B4Y034|B4Y034_MUSCA Hypoxia-inducible factor 1 alpha OS=Mustelus canis GN=HIF-1a PE=2 SV=1
----GSEKKCGGSSERRKEKSRDAARCRRSKESEVFYELAYELPLPHSITSHLDKASIMRLTISYLRMRKLLDAGNAEI--EADVEKHLNSFYLKALEGF
VMVLTQDGDMIYMSENVNKCVGLTQFELIGHSVFDFTHPCDHEEMREMLSHRQGPLKGKDQNTERNFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIRV
YKSNNEQTHCGYKEPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYQPEELLGRSVYEFYHAMDSDHLTKTHHDLFTKGQA
TTGQYRMLGKEGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSGLVEKEVVLSLDQTECAPVSDEKSEEP------------------------------
---------------------------SKSPVS-STKADNLFDKLKEEPEALTQLAPAAGDTVVSLDFSPS--EMQPFKEVPLYNDVMLPSSTNQ-KMAL
SPLPPTDSKKAIIFSFTIPQMNSSSSCPCTSQNSP-PSSPSDYCFNVDADISNEFKLDIVEKLFAIDPEAKHPFSVQDINDLDLEMLAPYIPMDDDFQLR
SLDQTSPLADSQTVGSLSSL--TNQIVSTPG-SPQNEKSSRTASPVRTELIHPVES--ESREAPNEDLSPMVLLLHNSPRKRKLENAAQAVGIGLLFQST
SQTWKRAKEFDANEQKTLVLLPTDIVTRLLTHSAEGS----SLPTLTNYDCEVNAPIQGNRTLLQGEEVLRALDQVN--
>tr|G5C5I4|G5C5I4_HETGA Hypoxia-inducible factor 1 alpha OS=Heterocephalus glaber GN=GW7_21080 PE=4 SV=1
----VYTLESRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLNTGDLDF--EDEMKAQMNCFYLKALDGF
VMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMKEMLTHRNGPVKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHV
YDTNNNQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMK------------------------------
------------------------ITQLFTKVE-SEDTSSLFDKLKKEPDALTLLAPAAGDIIISLDFSSNETDDQQLEEVPLYNDVMFPSSSEKLQLAM
SPLPASESPKPALLSFTMPQIQASPSDGSTRQSSPEPNSPSDYCFDVDSDMVNVFKLELVEKLFAEDTEAKNPFSTQDN-DLDLEMLAPYIPMDDDFQLR
SFDQLSPLESSSATTVSPSPTHLKETAHATTSSPYSNTPSRTTSPNRAKGAHVPVTLSQRNTIPEEELNPKIQALQNAQRKRKMEHDGQAVGI-TLLQQT
SLSWKRVKGCKSSEQKTIILIPSDLACRLLGQSMDES----GLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN--
>tr|G4WI69|G4WI69_MYXAS Hypoxia-inducible factor 2a OS=Myxocyprinus asiaticus GN=HIF-2a PE=2 SV=1
----AEKEKKRCCSERRKEKSRDAARCRRSKETEVFYELAHQLPLPQSISSHLDKASIMRLAISFLHTRKLLTSDCVTATETTEVDRLMDTWYVKSLGGF
ITVVTSDGDMIFLSENINKFMGLAQVELTGHSIFDFTHPCDHEEIRENLSFKTG--KVKDLNTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQLKV
YNGCPAHVLCGFKEPPLTCVVMMCEPIPHPSNIDTPLDSKTFLSRHSMDMKFTYCDDRVTELMGYNPEDLLGRSAYEFYHALDSDSVTKSHQNLCTKGQA
VSGQYRMLAKHGGYVWVETQGTVIYNSRNSQPQCIVCVNYVLSDIEEKSIIFSLDQTESLLKPQHLS---------------------------------
------------------------SF-FSPSKGL--DSEELYNKLKEEPEDLTQLAPTPGDTFISLNFGR-P-QYEEH---PGYSEVS-------S-IAP
SVSHTIHDGH---STFSVPQGSSA------------PSSPEDYYNTVDT----DLKVELTEKLLSLDTQTKTSYNQTDLSDLDLETLAPYIPMDGDFQLN
IC-QEEPSS-IGGTSVPYSNGPQIPPYHDPASTPLSSMGGRQNLQWPPG--KSVPANQQR--QCYRETRPVQLALASFKRS-------TQMAM---A-EQ
QTMWKRLR---HE--------LSGIASRLIRPSFETY----SLPELTRYDCEVNVPMQGNLHLLQGCDLLKALDQSS--
>tr|W5KA07|W5KA07_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
----AEKDKRRSTSERRKEKSRDAARCRRSKETEVFYELAHQLPLPHSVRSHLDKASIMRLAISFLRTRKLLTSGCRPS--ETEMDRQMDSLYVKSLEGF
VSVVTSDGDIIFLSENINKFMGLTQVELTGHSIFDFTHPCDHDEIRENLSLKTG--KGKELSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLKV
YNSCPPRVLCGFKEPPLTCVVMMCEPIPHPSNIDTPLDSKTFLSRHSMDMKFTYCDDRVTELMGYSPEDLLGHSVYEFYHALDSESCTKSHQNLCTKGQA
VSGQYRMLAKHGGYVWVETQGTVIYNSRNSQPQCIVCVNYVLSDIEEKNKILSINQTESSFKTHHMS---------------------------------
------------------------SF-FSQAGAAVATGGALFTKLKEEPEDLTHLAPTPGDAIIALDFAP----YKDY---PTCSKI-------------
SATHSTDEGQ---ATFSVPQAPSA------------PSSPGDYYSSVDN----DLKVELTEKLFALDTQTKNSCSQTDLSDLDLETLAPYIPMDGDFQLN
IC-PEDSPC-AAGANMVYG-SPQLPPYHDPACTPLSSMGGRQNLQWPPG--NAMPVNRHRPGEAYRDMSPARLAIASMKRS-------SQMTM---G-EP
EMIWKRMR---NENYREYSMLTEGVASRLLGPSFETY----CLPELTRYDCEVNVPLQGNLHLLQGSDLLWALDQAT--
>tr|Q696W2|Q696W2_CTEID Hypoxia-inducible factor 2 alpha OS=Ctenopharyngodon idella GN=hif-2alpha PE=2 SV=1
----AEKEKKRCSSERRKEKSRDAARCRRSKETEVFYELAHQLPIPHSISSHLDKASIMRLAISFLRTRKLLTSGCVAATETTDVDRLMDSWYLKPLGGF
ITVVTSDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKAG--KGKELNTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLKV
CNGCPARVLCGFKEPPLTCVVMMCEPIPHPSNIDTPLDSKAFLSRHSMDMKFTYCDDRVTELMGYSPEDLLGRSAYDFYHALDSDNVTKSHQNLCTKGQA
VSGQYRMLAKNGGYVWVETQGTVIYNSRNSQPQCIVCVNYVLSDVEEKSMIFSMDQTESLFKPHNLN---------------------------------
------------------------SF-FSPSKRSLGQSEALFTKLKEEPEDLTQLAPTPGDTIISLDFGQ-P-QYEEH---PMYSKVS-------S-VAP
PVSHSIHDGH---ATFSVPQAPSA------------PSSPGDYYTPVDS----DLKVELTEKLFSLDTQTKASCNQNDLSDLDLETLAPYIPMDGDFQLN
IC-QEEPAS-IGGTSIPCSRGPQMPPYHDPASTPLSSMGGRQNLQWPPG--KTMPANRQR--QNYRDMSPARLALTGFKRS-------TQMTM---G-EQ
QTLWKRLR---NENYREFSMQMDGIASRLIGPSFETY----SLPELTRYDCEVNVPLQGNLHLLQGSDLLRALDQST--
>tr|A0A0B5KUB3|A0A0B5KUB3_SCHPR Hypoxia-inducible factor 2 alpha A OS=Schizothorax prenanti PE=2 SV=1
----AEKEKKRHPSERRKEKSRDAARCRRSKETEVFYELAHQLPLPHSVSSHLDKASIMRLAISFLRTRKLFNSGRTVQQTQSQDDSQMDSLYLKSLEGF
VAVVTSDGDMIFLSENVSKFMGLTQVELTGYSIFDFTHPCDHEEIRENLSVKSMYGRGRDMSTGRDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQLQV
CSSRPPHVLCGFSEPPLTCVTMLCSPIPHPSNVDTPLDSKTFMSRHSMDMKFIYCDERVSSLIGYSPEELLGRSVYEFCHALDSESMTNSHQNLCNKGQV
VSGQYRMLAKHGGYVWMETQATVIYNNRNSQPQCIICINYVLSSVEEQSIIFSLDQTESLFKPYHMCNMG------------------------------
------------------------EL-FSQGGASSVAEDILFTKLKEEPEELAQLAPMPGDAIIALDFDR-P-DLEEP---TFFSKTT-------KVPVV
APSWVVDTPP---STFTRPQVPITPC----------PSSPVDYCGSGEC----DLKVELTEKLFASESVAINPKDSLDLSNLDLETLAPYIPMDGDFQLH
IC-LEEPVS--GLAD--TSPDMHVQPYQTAPNVPLSSKEGRQNLQWHPIRCDFTT---QRPV--QKRMSVGQIALVNFKRKRPSEFSSTDIPR------A
DGMQKRMKTMNVDSNRQYHMMHTGMISQLLGPSFDSY----CLPELTRYDCEVNVPLQGNLYLLQGSDLLRALDQST--
>tr|F8W2W5|F8W2W5_DANRE Uncharacterized protein OS=Danio rerio GN=epas1a PE=4 SV=1
----AEREKKRHPSERRKEKSRDAARCRRSKETEVFYELAHQLPLPHSISSHLDKASIMRLAISFLRTRKLFSSGHTVQQMRSQNLGQMDNLYLKSLEGF
VIVVTSDGDMIFLSENVSKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSIKSVYGRGKEMSTSRDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLQV
CSSRPPQILCGFSEPPLTCITMLCAPIPHPSNVDTPLDSKTFMSRHSMDMKFIYCDERVSSLIGYRPEELLGRSVYEFCHALDSENMTKSHQNLCNKGQV
VSGQYRMLAKNGGYVWVETQATVIYNNRNSQPQCIICINYILSSVEEQSVIFSLDQTEALFKPYHTYDMG------------------------------
------------------------EI-FSQNT--SIPQNNLFTTLKEEPEELAQLAPMPGDAIIALDFER-A-EFEEA---TFFSKSS-------KLPAV
GPSWVVDTPP---SSFTVPQVPKTPC----------PNSPVDCCGSGEW----DLKVELTEKLFAPESGATNPTDSLNLSDLDLETLAPYIPMDGDFQLH
IC-LEEPVP--GLAD-----------------------KQRQSLHWPPVGCGFNV---QRPV--QKGMSLGQRALLNFKRKRQSEFPLSDIPK---Q--T
DGMRKRMKPMNDDSSRQYNMMHTGMISQLLAPSFDSY----CLPELTRYDCEVNMPLQGNLHLLQGSDLLRALDQST--
>tr|H2NLG0|H2NLG0_PONAB Uncharacterized protein OS=Pongo abelii GN=LOC100939432 PE=4 SV=2
----GANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDI--EDEMKAQMNCFYLKALDGF
VMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGPVKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHV
YDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSIVIFHTITSSIEDENCNFKVENILMYK------------------------------
------------------------KVEEVSIVD-CKDNSDLCENPCGRAQWLTPVIPALWEAEAGGSLEVRETDDQQLEEVPLYNDVMLPSPNEKLQLAM
SPLPTAETPKPALLSFTMPQIQPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDT-DLDLEMLAPYIPMDDDFQLR
SFDQLSPLESSSAVTASPSPTHIHKETTSATSSPYRDTQSRTASPNRAKGVHLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGQAVGII------
-------------------------------------------------------------------------------
>tr|T1Q070|T1Q070_ACISI Hypoxia-inducible factor 2 alpha subunit OS=Acipenser sinensis PE=2 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELSHQLPLPHNVSSHLDKASIMRLAISFLRTRKLVSSIWPDNES--ESDKQMDGLYLKALEGF
IAVVTQDGDMIFLSENINKIMGLTQVELTGHSIFDFTHPCDHDEMRENLSLRNGFGKNKDLNTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQVKV
YNSCPPHTLCGFKEPPLTCVVMMCEPIPHPSNIDMPLDSKTFLSRHSMDMKFTYCDERVTELMGYWPEELLGRSVYEFYHALDSDRMTKSHQNLCTKGQA
VSSQYRMLAKHGGYVWVETQGTVIYNTRNSHPQCIVCVNFVLSDIEENSVIFSLDQTESLLKPHVLSMNS------------------------------
------------------------FF--NS--GVPAASEQLFTRLKEEPEELAQLAPTPGDTIISLDFG-----GPPFEEAPLYK-AVM--------PPP
NKPWAVEERNPE-AAFSVPQGSRLSTSSCSTP-----SSPGDYYSSLDN----DLKVELTEKLFAMDTAAKAQCTTLELNDLDLETLAPYIPMDGDFQLN
IC-QEEPPLSNSDASLP----TLVPFYHTPTSTPLSSMGGRQNVQWPPKWSC----HSQ-E-QGKD-VTPARTAVAHYKRKRQAEYRDQQLLME-----P
EMMWKRMKALKA-NYREFNML-MGMASRLLGPSFETY----SLPELTRYDCEVNVPVLGNLNLLQGGDLLRALDQAS--
>tr|V9KF35|V9KF35_CALMI Hypoxia-inducible factor 2 alpha OS=Callorhinchus milii PE=2 SV=1
----ADKEKKRSNSERRKEKSRDAARCRRSKETEVFYELAHQLPLPHNVSSHLDKASIMRLTISFLRTRKLLTSGLEN---ETDSERQMDSLYLKALEGF
ITVVTQDGDIIFLSENVNKHMGIAQVELTGHSIFDFTHPCDHEEIRENLTLKNGFGKNKDLNTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGHIKM
YNTCLPHTLCGYKEPPLTCLIMMCEPIQHPSNIDVPLDSKTFLSRHSMDMKFTYCDERVTTLMGYHPEELLGRSVYEFYHALDSDHMTKSHQNLCTKGQA
VTGQYRMLAKHGGYVWVETQGTVIYNSRNSQPQCIVCVNYVLSDVEEKNVMFSMDQTESLFKPCLPLRN-------------------------------
------------------------VN-GRYINGASVDSELLFSKLKEEPEELAQLAPTAGDAIISLDFGINQ-QLEKT---SLYNKGA-------M-PPP
NKQWPVEITK---HSFVVPRVTATPS----------PSSPGDYYSSMDN----DLKIELTEKLFSMDTQAKNQCSQVELSDLDLETLAPYIPMDGDFQLS
IC-CEEPPT-NT-NS-----HIPLPQYHGSVNTPVSSMGGRPSIQWPPKWRTGHPAQRVK--QHGKDISPALTAFTNLKRKRQLEFGELSAEC---P-YA
QFLWKRMKAIKCE--------LTGMASRLLGSSFVSY----SLPELTRYDCEVNAPVVGNSTLLQGRELLRALDQAT--
>tr|T1Q050|T1Q050_POLSE Hypoxia-inducible factor 2 alpha subunit OS=Polypterus senegalus PE=2 SV=1
----ADKEKKRNSSERRKEKSRDAARCRRSKETEVLYELAHQLPLPHSISSHIDKASIMRLTISFLRTRKLLSSTIPSS--DSGSDKYIDSLYLKTLDGF
IAVVTQDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSPKHGFSKNREASSVRDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLKM
YNSHHPHTLCGFKEPPLNCVIMICEPIPHPINIDIPLDSKTYLSRHSMDMKFTYCDERITELMGYSPEELLGRSIYDFYHALDSDSLTKSHHNLCTKGQA
VSGQYRMLAKHGGYVWIETQGTVIYNSRNSQPQCIVCINYVLSEIEEDSIIFSMDQTESLFKPHVIS---------------------------------
------------------------MS-NFFSSGMPTSSELLFTKLKEEPEELAQLAPTPGDAIISLDFGA-Q-PFDEP---PIFNQKA-------I-HPP
KKPWPQVENI---GAFIVPQGACTPS----------PSSPGDYYSTMDS----ELKVELTEKLFAMDTESKSQCKTPELSDLDLETLAPYIPMDGDFQLN
IC-QEEHPL-KPPTSLSYA-GSVAPPYLTPSSTPLSSMGGRQNIQWPPKWRIHQPHHQQR--HQNKEMIAVQQDFISFKRKRHLEFSQQEEAL---G-N-
-ATWKKLKAVKAEGYREFTVLLEGMATRLLGPTFDSY----SLPELTRYDCEVNVPLHGHLNLLQGSDLLRALDQGS--
>tr|T1Q062|T1Q062_9ACTI Hypoxia-inducible factor 2 alpha subunit OS=Lepisosteus platostomus PE=2 SV=1
----TADRKKRSSSERRKEKSRDAARCRRSKETEVFYELAHQLPLPHNVSSHLDKASIMRLTISFLRTRKLLSSTWPDNVS--EADRQMDSLYLKALDGF
IAVVTQDGDMIFLSENINKFLGLTQVELTGHSIFDFTHPCDHDEIRENLSFKPGFGKNKDLNTERDFFMRMKCTVTSRGRTVNLKSASWKVLHCTGHLKV
YNSCPPHVLCGFKEPPLTCVIMMCVPIPHPSNIDMPLDSKTFLSRHSMDMKFTYCDDRVTELMGYCPEDLLGRSVYEFYHALDSDSMTKSHQNLCTKGQA
ISGQYRMLAKHGGYVWVESQGTVIYNSRNSQPQCIVCVNYVLSEIEESLVLFSMDQTESLFKPHVLSMGS------------------------------
------------------------FF--SN--GAAASSELLFTKLKEEPEDLAQLAPTPGDAIIALDFG-----GPQYEEAQMYSKAAM--------APP
SKTWPVEAQQPE-AAFSVTQPPSSTTSSCSTP-----SSPGDYYSPMDN----ELKVELTERLFALDTDPKSPYTTSEVSDLDLETLAPYIPMDGDFQLN
IC-QDELPLPSS-ANLP----TVMPPYHTPSSTPLSSMGGRQNLQWPPKRSN----YRQ-Q-PQKD-MSPSRIALVSFKRKRLLELAEQPLPGE-----S
EMIWKRMRNLKT-SYREYSMP-EGMVSWLLGPSFESY----SLPELTRYDCEVNIPLQGNLNLLQGSDLLRALDQAT--
>tr|T1Q053|T1Q053_PROAN Hypoxia-inducible factor 2 alpha subunit (Fragment) OS=Protopterus annectens PE=2 SV=1
----ADKEKKRTSSERRKEKSRDAARCRRSKETEVFYELARQLPLPHSISTHLDKASIMRLTISFLRTRKLLSSAWP--K-ETESDCQMDGLYLKALEGF
ITVVTQDGDMIFLSENVSKYMGLTQVELTGHSIFDFTHPCDHEEIKENLCLKN-YGKNREMNSERDFFMRMKCTVTSRGRTVNLKSATWKVLHCTGHIQT
HGSCQQHTLCGFKDPLLAYLIIVCAPIQHPSNIDIPLDSKTFLSRHSMDMKFTYCDDRITELMGYHSEELLGRSVYEFYHALDSENMTKTHQNLCTKGQV
ISGQYRMLAKHGGYVWIETHGTVIYNSRNSQPQCIICINYVLSTIEENNTVFSVDQTESVFKPHLMTMNS------------------------------
------------------------IF--SR--SVLAQGDLLYRKLKEEPDDLEQLAPTPGDAVVSLDF-----GTQRFDDSSVYKKSIM--------PLT
NTSWTPEAKKPE-PAFSLPQVPSCSSSSCSTP-----SSPGDYYGPLES----DLKTELVEKLFAMDTESKNQCNTADFNELDLETLAPYIPMDGDFQLN
IC-QEEHPVSYPQSGLAD---KGLPPYQAPASTPLSSQGGRANVQWPPKWRS-GTQQSQ-Q-RGKD-VTPAMIAISSLKRKRQLQYI-QEISGD----AC
HAIWK--------------------------------------------------------------------------
>tr|F7F7N2|F7F7N2_MONDO Uncharacterized protein OS=Monodelphis domestica GN=EPAS1 PE=4 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHNVSSQLDKASIMRLAISFLRTHKLLSSVCTENETEVETDQQMDNLYLKALEGF
IAVVTQDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKSGFGKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKV
YNSCAPHSLCGYKEPLLTCLIVMCEPIQHPSTMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSESMTKSHQNLCTKGQV
ISGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIICVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNN------------------------------
------------------------IF--DT--EIPVKSNFLFAKLKEEPEELAQLAPTPGDAIISLDFG-----NQSFEESSTYNKA-L--------LTP
SQPWPGDMKNHE--SFTVPQMASTSN----------PSSPGDYYSSLDE----NLKMEMIEKLFAMDTESKNQCNTTDFNELDLETLAPYIPMDGDFQLS
IC-QEERPQLNTQSSIFGS--KTLPPCYGPASTPLSSMGGRSNTQWPPKWT-RRSPPNK-P-RGPDKMNPAVIALSKLKMKRQLEYE-QDMSGG----LP
HLMWKRMKSLKG-AYQDYNP-KSGMTSRLLGPSFEPY----LLPELTRYDCEVNVPVPGSSTLLQGSELLRALDQAT--
>tr|Q6GP97|Q6GP97_XENLA MGC80589 protein OS=Xenopus laevis GN=epas1 PE=2 SV=1
----AEKEKKRNSSERRKEKSRDAARCRRSKETEVFYELAHQLPLPQSISSHLDKASIMRLAISFLRTHKLLSSVCADRNIETDSEKQMDNLYLKALEGF
VAVVTQDGDMIFMSENVNKYLGLTQVELTGHSIFDFTHPCDHDEIRENLSMKTGSGKNRDANTEHDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGHVKA
YNSYHPHSLCGFKEPILSCLIMMCQPIQHPSNIDIPLDSKTFLSRHSMDMKFTYCDDRIIELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCAKGQV
VTGHYRMLAKHGGYLWVETQGTVIYNTRNSQPQCIVCVNYVLSEIEKNDVVFSMDQTESLFKPHFLTMNS------------------------------
------------------------IF--SS--S--VKSDFLFTKLKEEPEELAQLAPTPGDEIVSLDF-----GSQTFDEPASFNSSVQ--------TSP
SKPWPLEVKNLD-PSFKAPQVANSSNSTCSTP-----SSPEAYYSSLDE----DLKIELIEKLFAMDTEAKNQCNTNDFNDLDLETLAPYIPMDGDFQLN
IC-QEESTINTPQCSVLEK-MAPLTPYHTGATPPLSSMGGRPNVQWPPKWRS-SLPHNQ-Q-RGKD-LHPTEIPFCSVKRKRPLDYG-PPVDVG----LT
LLMWKRIKALKS-SYHDYNMQRKGLTSCLIGPSFESY----LLPELTRYDCEVNVPVVGNSTLLHGRDLLRALDQTT--
>tr|H3BEE1|H3BEE1_LATCH Uncharacterized protein OS=Latimeria chalumnae PE=4 SV=1
----VFVTPHRVCSEKRREKSRDAARCRRGKESEMFFHLAQQLPAPYSITSRLDKASIMRLTISYLRLRHLLSALTLKGEKEASGFPEETDLVFTALKGF
LMVVSQTGEMIFLSDNATGFLGPTQVELVGQNLFDFIHPCDQEEIRNVLSLKH---IRKKQSKDCDFFVRMKCTLTNQGRMVNLKSASWKVLHCTGQVKL
TPSHQ--------GAPQGCLVLLCEPIPFPSELETPVSKEMFLTRHSLDMKFTYCDKRVKDLIGYQESELLGRSVYEYYHVLDADRIRKSHHNLFAKGQT
STGQYRMLCKHGGYVWVQTDASVIYSDRNSQPRCVICINYVLSRSLETEIIVSLEQTERLFKSWDVLHTD------------------------------
------------------------S--------MLPESRLPFRKLRESPEELVQLSPSPGDVVKSFDFTAQA---TCPVAMVIYP-----P-------PS
SQATPLLTPNT---------TPRTPST---------PNTRRQHYNPRKN----TFEVELIEKLFASDLDSQTRCSPGDFNDLDLETLAPYIPMDGDFELT
IC-QEHPSPS---MSPSCC--------YGEARTCMHYGGIQQRILWPP---AS-----RRPPFHFTGRSVSALIFLSLKRKQELGFPPEECT-------E
EILWKRKRLLSGFNFPFFFPL-ADLTRYWL----TSS----VLPVLNSLDCEVNAPVHGRSRLLQGNELLRVLDQAA--
>tr|S4RYA8|S4RYA8_PETMA Uncharacterized protein (Fragment) OS=Petromyzon marinus PE=4 SV=1
----TEEKNNNATSERRKEKSRNAARCRRSKETEVFCELARELPLPQSVSASLDKASVMRFAISFLRMRKLLASDGSTE--HIDSMGDIDPAFLKVLEGF
FLVMNHDGDIVYLSDNVSKYLGTTHVDLVGQSIFDFTHPCDHEEIKEILSCKQGSAKNKETPTEIDFLMRMKCTITNRGRTVNLKSASWKVLNCSGHQKV
CGSSSTESSHGFKDPAQTYLVLICQPIPHPAELEAPLDSHTFLSRHTLDMKFSYCDDRVVDLIGYCPEELLGKSVYEYYHALDSDNITKSHHSLFSKGQA
KTGQYRMLAKHGGYVWVQTQASVIYNSRSAQPQSVVCIHYVLSGVEENTTIFSLEQTERLFKLQDTAQGA------------------------------
------------------------EGDEACPREAPQDSGRLYAMLKEEPDELAQLAPTPGDTIVPLQFNS-T-VFIYT-----YKNYNSAP----LC---
-----DDTT----SPFTAHQMSSTPS----------PGSPEDVYASC-N----DLRVELVEKLFAKSTD--QNSYTDDYSTVDLEMVAPYIPMDGDFQLC
LS-LQEQMAANPLSS-VTKPAINDSSFYGATDQGLA-AAGKCGSSWPYGRHFASVAAQQRPCKRSPE---------NLKRKWHLDGGITHMV------DS
HPPWKRSKVWDDTPPLQQQYLPTGLASCLLGRSFEGV----HLPTLTSYECEVNAPVQDIQNLLQGKDLLMALDQAT--
>tr|H9G8J6|H9G8J6_ANOCA Uncharacterized protein OS=Anolis carolinensis GN=EPAS1 PE=4 SV=2
----AEKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHNISSHLDKASIMRLAISFLRTHKLLSSVCTENKKEIESDQQMDNLYLKALEGF
ITVITQDGDMIFLSENISKYMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGFGKNKEMSMERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQIKV
YNTCPPHALCGYKEPLLSCLVLMCEPIQHPSNTDIPLDSKTFLSRHSMDMKFTYCDDRITELVGYHPDELLGRSAYEFYHALDSENMTKSHQNLCAKGQV
VTGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIICVNYVLSEIENNDIVFSMDQTESLFKPRMMAMNS------------------------------
------------------------VY--DN--GIPVKSDFLFTKLKEEPEELAQLAPTPGDAIISLDF-----GTQKFEEISTYNKA-V--------MTP
NKPWPPEAKSQE-PSFTLPQVASSSNSSCSTP-----SSPGDYYTSLDE----DLKIEMIEKLFAMDTNAKNQCSSTDFNELDLETLAPYIPMDGDFQLS
IC-QEERPLSNAQNSAFGNQSA-LLPYYAQATTPLSSMGGRPNTQWPPKWRK-ASTPNK-Q-RGID-INPARIALASLKLKRHLEYE-QHLNGP----GT
HLMWKRMKILRG-PYQDFSVPRSGMTSRLLGSSFEPY----LLPELTRYDCEVNVPMVGSSMLLQGSDLLRALDQAT--
>tr|Q8QGM4|Q8QGM4_FUNHE Hypoxia-inducible factor 2 alpha OS=Fundulus heteroclitus PE=2 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHQLPMPHSVSAHLDKASIMRLAISFLRTRKLIATSSGSGSCNGAEDELMDNMYLKSLEGF
ITVVTSDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKSSFRKGKDVSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLKM
YDGCPSRVLCGYKEPPLTCAVLMCEPIQHPSNIEAPLDSRTFLSRHNMDMKFTYCDDKVTELIGYSPEDLMGRSIYEFYHALDSDSVTKSHHNLCTKGQA
VSGQYRMLAKNGGYVWVETQGTVIYNSRNSQPQCIVCINYVLSDVEEKSVIFSLEQTEALFKTPHMS---------------------------------
------------------------RF-FTAEGAGRTPGDSLFTTFKEEPDELAQLAPTPGDTIISLDFGH-P-ELEKSQHPAPFTPVSSAS----MHPSG
PPSWTSESRK---GAFTVQQNPSA------------PSSPGDYYSSVES----DQRLELTEKLFALETENDSDAHTEDLSDLDLETLAPYIPMDGDFQLN
II-PESEPL-MS-AS-SCMMGPQSPHFRGPASTPLSS------MQWPPKACEQNIS--QR--QAYKDVNPARV---SIKRS-------NQMAL---G--T
DVVWKKMRGDG--SYTEYNPLTEGIASRLLGPTFEPS----CLPELTRYDCEVNVPLQGSLHLLQGCDLLQALDQCI--
>tr|S4R4L9|S4R4L9_PETMA Uncharacterized protein OS=Petromyzon marinus PE=4 SV=1
----TLSLPSRVNSERRKEKSRDAARCRRSNETEVFYELANELPLPHSVTSHLDKASIMRLAISYLRMRKLLHNGAVV----EDCQEEMDSLFGKALEGF
VMALTEEGDMVFLSDGVNKCVGLAQVDLMGHSIFDFVHPCDQEEVREMLVYRQ----VKAPPSEVCQXMRMKCTLTNRGRTVNLKSASWKVLHCSGHMKL
YEGSAASAGGKRARXQVLLLMKSRTPPARRANQQSALDFQTFQNPHVKFMVHACCTEEILMLFENLPEELHFSATPTTGHTAHAHPLVCSSHAVFTKGQA
VTGQYRILAKGGGYAWVETQATVIYSSRNSQPQCVVCVNYVLSGIVENDTIFSLEQTERLFKPNKAAVGQ------------------------------
------------------------V-----SEGTDEDMALLYTQLKNEPDELAQLAPTAGDVVVPLDFGTG---LASFDDVPLYNDVMMAASPEPMPSPA
TPTKAFAELPA--GPVGDPSLTHGPSSPS-------PNSPSDYYS----AVGGDLKVDLIEKLFAVDSEIKEVSRVKSLDDMDLEMLAPYIPMDGDYQLC
LSLPDGPLP----SS-------LPPAAPQPP-----------------SRH---------MPAEDAEIYLLSIIYNANNKN--VTLYS-----------S
VGPVKKMPKHTISISPYAVVQSTDLVSRLLGPTLEDI----TLPMLNSYDCEVNAPVQDSRTLLQGEELLKALDQLS--
>tr|M3ZS27|M3ZS27_XIPMA Uncharacterized protein OS=Xiphophorus maculatus PE=4 SV=1
----------------------------------------------------------MRLAISFLRTRKLLTTS----HCDGEEDRLMDNLYLKSLEGF
VTVVTSDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKSSFRKGKDQSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQLKM
YDGCPSRVLCSYKEPPLTCAILMCEPIPHPSNIDVPLDSRTFLSRHSMDMKFTYCDEKVTELMGYTPEDLLGRSVYEFYHALDSDSVTKSHHNLCSKGQA
VSGQYRMLAKNGGYIWVETQGTVIYNSRNSQPQCIVCINYVLSDVEEKSVIFSLEQTEALFKSPNMS---------------------------------
------------------------SF-FTTEGASMNSGASLYKKFKTEPEDLAQLAPTPGDTIISLDFDR-T-EFEESQQPAPFTPVSSSP----MPPPG
PACWTIESQHA--RAFTVQQKPSA------------PSSPGDYYSSVES----DLRVELTEKLFALETENDSTAHTEDLSDLDLETLAPYIPMDGDFQLN
II-PESEPQ-LS-AS-SYMMPPRNPPFRGLAGTPLSS------MQWPPKACEQNTS--QR--QAYKDLDPARV---SIKRS-------NQMAL---G--T
DAIWKKMRGDG--SNKEYNVM-SGIASRLLVPSFEPS----CLPQLTRYDCEVNVPLQGNLHLLQGCDLLRALDQST--
>tr|F7D2J8|F7D2J8_HORSE Uncharacterized protein OS=Equus caballus GN=EPAS1 PE=4 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGF
IAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGFGKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKV
YNNCPPHSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQV
VSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNG------------------------------
------------------------IF--DNSGEVAAKSNFLFTKLKEEPEELAQLAPTAGDAIISLDFAM-SPWSQNFEESSAYGKA-I--------LPP
SQPWAGELRSHE-PAFTVPQAASSS--S--------PSSPGDYYTSLND----DLKIEAIEKLFAMDTEAKDQCSTTDFNELDLETLAPYIPMDGDFQLS
IC-PEERLLPNPQTNIFGT--KSLPLCCGQASTPLSSMGGRSNTQWPPKWP-GASPPHK-P-RDPDTMSPAMIALSKLKLKRQLEYE-QDMSGA----PS
HLMWKRMKSLRGGQYQDYGL-KSGMASRLLGPSFEPY----LLPELTRYDCEVNVPVPGSSTLLQGGDLLRALDQAS--
>tr|W5P6T6|W5P6T6_SHEEP Uncharacterized protein OS=Ovis aries GN=EPAS1 PE=4 SV=1
----TLVSQLRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEADADQQMDNLYLKALEGF
IAVVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGFGKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKV
YSNCPPPQFCNTHSPNAENLPLLC-PLQHQTHLRIPVQSSVFLERISLNLLFFFSQFRITELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQV
VSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESPFKPHLLTMNS------------------------------
------------------------IF--DNSGKVAVKSNFLFTKLKEEPEELAQLAPTAGDTIISLDFG-----TPNFEESSAYGKG-I--------LPP
SQQWTGEVKSHE-PAFTVPQAANSS--S--------PSSPGDYYTSLDD----NLKIEAIEKLFAMDTEAKDQCGTTDFNELDLETLAPYIPMDGDFQLS
IC-PEESLLPTPQSNTFGS--KSLLQRCGQTYTPLSSMGGISSTQWPPKWP-GTVPPHK-P-QGPDVMSPAMIALSKLKLKRQLEYE-QDLSGG----PS
HLMWKRMKSLRGGQYQDYSL-KSGMASRLLGPSFEPY----LLPELTRYDCEVNVPVPGTSTLLQGGDLLRALDQAT--
>tr|H2SMF4|H2SMF4_TAKRU Uncharacterized protein (Fragment) OS=Takifugu rubripes GN=LOC101067536 PE=4 SV=1
----PRLSLCRTSSERRKEKSRDAARCRRSKETEVFYDLAHQLPLPHSVSAHLDKASIMRLAISFLRTRKLLDTSCSS-GSNCDEDKEMDSLYLKSLEGF
VAVVTSDGDMIYLSENINKFMGLTQVDLTGHSIFDFTHPCDHEEIRENLSLKTAYDKGKELSSERDFFMRMKCTVTTRGRTVNLKSAGWKVLHCTGQLKM
YNSCPPRGLCSFREPPLTCAVLMCEPIPHPSNIDTPMDTRTFLSRHSMDMKFTYCDERVTELMGYTPEDLLGRSVYDFYHALDSDKVTKSHQNLCTKGQA
VTAQYRMLAKNGGFIWVETQGTVIYNSRNSQPQCIVCINYVLSDIEEKSTIFSLEQIEALFKPRHMS---------------------------------
------------------------GF-LTEGGVGVVPGDALFTKLKEEPEDLTQLAPTPGDTIITLDFAR-P-QFEETRQAPGYG----------MALPD
VPSWSNESLK---AAFTMQQHPSA------------PSSPGDYYSSVDS----DLKVELTEKLLILDTEDNGPANTMDLSDLDLETLAPYIPMDGDFELN
IE-PLE----NSNAS-SCMMAHQNPPYRAPARTPLSSMGGRQNLQWPPKSFEQSIP--QS--TGVTSVLWPNVSNILLRSD-------CGGCQ---N---
-LLWVHSRAFIGP--------FPGIASRLLGPSFEST----CLPELTRYDCEVNVPLQGNLHLLQGCDLLRALDQAT--
>tr|M4XYS7|M4XYS7_SEBSC Hypoxia-inducible factor-2 OS=Sebastes schlegelii GN=HIF-2 PE=2 SV=2
----AEKEKKRSSSERRKEKSRDAARCRRSKETEVFYELANQLPLPHSVSSHLDKASIMRLAISFLRTRKVVTTGC---SVDGDEDGQMDSLYLKSLEGF
VTVVTSDGDMIFLSENINKFMGLTQVDLTGHSIFDFTHPCDHEEIRENLSLKTGFGKGKELSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGTLKT
YSSCPPRVLCGFKEPPLTCAVLMCEPITHPSNIDTPLDSRTFLSRHSMDMKFTYCDDRVSELMGYSPEDLLGRSVYDFYHALDSDGVTKSHHNLCSKGQA
VSGKYRMLAKNGGYVWVETQGTVIYNSRNSQPQCIVCINYVLSDIEEKSMIFSLKQTESVFKPHHMN---------------------------------
------------------------NF-FSAGGAGVTPGDALFTKLKEEPEELAQLAPTPGDTIITLDFDR-P-QFEEPQQPAGYTTVSAAA----MPPPG
PPSWASESHKP--GAFTVQQNPSA------------PSSPGDYYSSVDS----DLKVELTEKLFALDTEKDSPENTRDLSDLDLETLAPYIPMDGDFQLN
II-PESEPL-S--AS-SYILGHQSPPYQAPASTPLSSMGGRQNLQWPPKTYEQNAT--QR--QAYRDMSPARV---SIKRS-------TQMSV---G--S
DLIWKKMRGDS--NYT-YNMQSQGIASRLLGHSFESS----CLPQLTRYDCEVNVPLL---------------------
>tr|Q9PTB3|Q9PTB3_COTCO Hypoxia-inducible factor 2 alpha OS=Coturnix coturnix PE=2 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHNVSSHLDKASIMRLAISFLRTHKLLSSVCADNENELEADQQMDNLYLKALEGF
IAVVTQDGDMIFLSENVNKYMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGFGKNKEMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKV
YNTCPPHTLCGYKEPLLTCLIIMCEPIQHPSNIDIPLDSKTFMSRHSMDMKFTYCDDRITELIGYHPEELLGRSVYEFYHALDSENMTKSHQNLCTKGQV
VTGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIICVNYVLSEIEKNDVVFSMDQTESLFKPHLLTIST------------------------------
------------------------AF--EN--GISRKSDLLFTKLKEEPEEVAQLAPTPGDAIISLDFEL-HPGIQKFEEPPDYTSA-V--------LTP
NKPWPVEVKSHE-PSFTMPQIPNSSNSSCSTP----N-SPEDYYTSVDD----DLKIEVIEKLFAMDTESKSQCNSTDFNELDLETLAPYIPMDGDFQLS
IC-QEERPHSSAQSTVFMS-RSSLPPYHNQASTPLSSMGGRPNTQWPPKWRT-SSPPNK-Q-RGID-INPARIALSSLKLKRQLDYE-QQLTGG-----S
QLMWKRMKFLKG-HYQDYTVQKSGVTSRLLGSSYEPY----LLPELTRYDCEVNVPVLGSSTLLQGSELLRALDQTT--
>tr|K7G1Q3|K7G1Q3_PELSI Uncharacterized protein OS=Pelodiscus sinensis GN=EPAS1 PE=4 SV=1
----ADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHNVSSHLDKASIMRLAISFLRTHKLLSSVCVDNESDLDIDQQIDNLYLKALEGF
IAVVTQDGDMIFLSENINKYMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKTGFGKNKEMSTDRDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVKV
YNSCPSHSLCGYKEPLLTCLIIMCEPIQHPSNMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCAKGQI
VTGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIVCVNYVLSEIEKNDIVFSMDQTESLFKPHLLTMNT------------------------------
------------------------IF--DN--GVPVKSDFLFTKLKEEPEELAQLAPTPGDAIISLDFAQ-HNGTQKFEEASIYNKAAV--------LTL
NKQWPGEVKSHE-PSFTMPQVASSSNSSCST-----PSSPGDCYSSLDE----DLKIEMIEKLFAMDTESKNQCNSTDFNELDLETLAPYIPMDGDFQLS
IC-QEERPLPNAPSAVFSNSKSSLPPYHVRGSTPLASMVGRPGTQWPPKWRS-SSSPNK-Q-HGID-INPARTALASLKLKRQMDYE-QQRTGA-----S
HLMWKRMKILKG-HYQNFNVQKSGVTSRLLGQSYEPY----LLPELTRYDCEVNVPVLGSSTLLQGSDLLRALDQAT--
>tr|L7MG71|L7MG71_9ACAR Putative hypoxia-inducible factor 1 alpha subunit basic helix-loop-helix transcription factor b (Fragment) OS=Rhipicephalus pul
----SAPKERRKNSEKRKEKSRDAARCRRSKESEIFTELSQQLPLPESVACQLDKASVMRLAISYLRLREILEPIAEVA--KSAACSPYDSSVLEALDAV
LLVLSAEGEIVFLSDNVGRHLGLNQVDLMGQSVYEYCHPCDHDELKAALLPKP--EDHDLSPQPCHFLMRLRCTLGSKGRGVSVKSASYKMMQCVGTRVS
REVAPPEEEQPKEEERRHFLVCVAQPIPHPSNIEAPLGTHTFLSRHNPSMCFTHVDDRTETFLGYSSEELLGKSVYSYFDPRDVLNLQQDFKTLFAKGQC
ETGQYRFLAKHGGCVWVLTQATLIYENSCSKPQCVVCVNYVLSGASGKHEVLAEQQLTSTAVKPKEPEPK------------------------------
------------------------LQ-FLIFA----DTGFTAVLRDDEPEDLTHLAPRAGDDTIPLEGLPSLGDAFSL--SDIYGDEN-------KLLPD
YALLPPEEDCP--DPLSS----STPPSSD-------------SCSDVPSE-------SPVDRFAGLELKPE----GTDLQDDDFDMRAPYISMNGDFPLL
-PDPQDSSP--GSPT------------------PKSSLAALLVAELPPEWTHSGPHHPQSGLSAASDGRPHAYV--TTALEQKMGMPSTERAL------Q
LASPKRMRIDLRG-YDKRCPPP---APLLLD-----P----TLQDLSQLDAEVNAPIQ---QLLTGEDLLSALDQSV--
>tr|V5HIH3|V5HIH3_IXORI Putative hypoxia-inducible factor 1 (Fragment) OS=Ixodes ricinus PE=2 SV=1
---------RRKNSEKRKEKSRDAARCRRSKESEIFSELSQQLPLAEGVTSQLDKASVMRLAISYLRMHEILEPIVELK--EKKVSSAYDASVLEALDGF
LVVLSADGDVLFLSENISRHLGLNQVDLMGQSLFEFCHPCDHDELKEVLCPGGKAPEGEKFPQPCSFFVRLRCALGSKGRGVGVKSASYKVLHCVGHRVL
RDVAPREDDPEEEEEQRRFVVCVAQPIPHPSNIEVPLGSRTFLSRHSPSMRFTHVDDRIEKFLGYTSDELLGKSVYSYFDARDISALQKDFKTLFSKGQC
ETGQYRFLSKHGGYVWVLTQATLIYENSCSRPQCVVCVNYVLSGTSQEHEVVSEDQVIKAAAAPEPSE-K------------------------------
------------------------RP-FLMFA----DSGLTVLKEDSDPEDLTHLAPQAGDDSIPLEELPSLGDTFVL--SDPYGDNS-------KLLPD
YALLPPEEDCP--DPLSS----STPPASD-------S-CSDSLLSDVPSE-------SPVDRFAGLDLRPD----GTDLQEDEFDMRAPYISMSGDFPLL
PPDPQDSPQ--GSPT------------------PKSSLAALLVSPELPDWGQR-ATGRNAGDTAGDGRRHGVYV--TAPLEQKMAMPSS-GGG------A
LGSPKRMRVDPQG-YDRRFPAP---APLLLD-----P----SLQDLSQLDAEVNAPIQ---QLLTGEDLLNALDQSV--
>tr|C0HAF0|C0HAF0_SALSA Hypoxia-inducible factor 1 alpha OS=Salmo salar GN=HIF1A PE=2 SV=1
----VPEKKSRVSSERRKEKSRDAARYRRGKESEVFYELAQELPLPHSVTSNLDKASIMRLAISYLHMRKLLSTDDKTVEEESEMDSQLNVSYLKALEGF
LMVLSEDGDMIYLSENVNKYLGLAQFDLTGLSVFEYTHPCDHEELREILVHRT-TSKSKGPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHV--
--APAEQNPCGHKEPPVSYLVLVCDPIPHPSNIEAPLDTKTFLSRHTLDMKFTYCDERT-ELMGYDPEDLLNRSVYEYYHALDSDHLIKTHHNLFVKGQV
STGQYRMLAKIGGFVWVETQATVIYNNKNSQPQCVVSVNFVLSGIE-EKMVLSLEQTEDMRSVKKELVEE------------------------------
------------------------E-ELFTQAMEP-PLASLYDRLKEEPEALNLLAPAVGDTIISLDFSNPD---ILLKEVPLYNDVMLPSTSDKLALPH
SMQPPSEQPLI---------KASTP-----------PDIALNFCFPMDSDISAALKLDLVERLFAIDTEPKTPFTSQGMEDLDLEMLAPYIPMDDDFQLR
LS-PEEPLS----SP-------LTQDVHSYTDSPFSAPSIRTASP---PAS---------APQMDREIYLRTLATQ-SQRKRKLALYQ--------G-NP
PGPGKKLKVSEL-SNRTILLLPTDLASCLLGISSEGF----TLPQLTRYDCEVNAPVVGRQHLLQGEDLLCALDQVN--
>tr|A5H732|A5H732_ESOLU Hypoxia-inducible factor 1 alpha OS=Esox lucius GN=HIF-1a PE=2 SV=1
----VPEKKSRVSSERRKEKSRDAARCRRGKESEVFYELAQELPLPHSITSNLDKASIMRLAISYLRMRNLLSTDEGAVEEESELDSQFNGSYLKALEGF
VMVLSEDGDMIYLSENVNKCLGLAQFDLTGLSVFEYAHPCDHEELREMLVYRT-TSKSKEPNTDRSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
HEVPAEQGSCGHKEVPVPYLVLVCDPIPHPSNIEAPLDTKTFLSRHTLNMKFTYCDERT-ELMGYNPEDLLNRSVYEYYHALDSDHLTKTHHNLFTKGQV
STGQYRMLAKRGGFVWLETQATVIYNNKNSQPQCVVCVNYVLSGIEEEKLVLSLEQIEDMRPVKKERIEE------------------------------
------------------------EEVLFTQAMEK-PVTSLYDRLKAEPEALTVLAPAAGDTIISLDFSSPD---VLLKEVPLYNDVMLPSTSDKLALPL
SLLPPSEQPLA---------KASNP-----------PDGPLDFCFPMDSDINSAFKLDLVESLFAIDTEPKTPFSSQAMEDLDLEMLAPYIPMDDDFQLR
LS-PEEPLT----SP-------LTKEVHNYPGSPFSAPSSQTTSPAPASAS---------AP---QEISLSKLVTQ-AQRKRKLSLSQ--------G--P
PDLGKKQKVCDR-SNRTVLLLPTDLASRLLGISSEGF----TLPQLTRYDCEVNAPVAGRQHLLQGEELLRALDQVN--
>sp|Q98SW2|HIF1A_ONCMY Hypoxia-inducible factor 1-alpha OS=Oncorhynchus mykiss GN=hif1a PE=2 SV=1
----VPEKKSRVSSDRRKEKSRDAARCRRGKESEVFYELAQELPLPHSVTSNLDKASIMRLAISYLHMRNLLSTDNE--EEEREMDSQLNGSYLKAIEGF
LMVLSEDGDMIYLSENVNKCLGLAQIDLTGLSVFEYTHPCDHEELREMLVHRT-TSKSKEPNTERSFFLRMKCTLTNRGRTVNVKSATWKVLHCSDHVRV
HESPAEQIPGGHKEPSVPYLVLVCDPIPHPSNIEAPLDTKTFLSRHTLDMKFTYCDERT-ELMGYDPEDLLNRSVYEYYHALDSDHLMKTHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNYVLSGIEEEKMMLSLEQTEDMRPVKKELE--------------------------------
---------------------------LFTRAVET-PLSSLYDRLKEEPEALTLLAPAAGDTIISLDFSSPD---ILQKEVPLYKDVMLPSTSDKLALPL
SLLPPSDQHLV--V------STSTP-----------PDSPLDFCFPMESDINAEFKLDMVETLFAINPEPKTPFTLQAMEDLDLEMLAPYIPMDDDFQLR
LS-PEEPLS----SS-------LTQEVHSYPGSPFNAPGSLTASPALAPAS---------VPQMDREISLRSLASQ-AQRKRKMSLSQ--------G--H
PGPGKKLKVSEL-FNRTILLLPTDLASRLLGISSEGF----TLPQLTRYDCEVNAPVGGRQLLLQGEELLSALDQVN--
>tr|A0A0B5L2B1|A0A0B5L2B1_9TELE Hypoxia-inducible factor 1 alpha A OS=Schizopygopsis pylzovi PE=2 SV=1
----APG-KKRVSSERRKEKSRDAARCRRGKESEVFYELARELPLPHGVTSNLDKASVMRLALSYLRLRKLLNTDVLN-V-ESELDSQWNSSYLKALDGF
LMVLSADGDIVYLSENVSKCLGLPQIDLTGHSVFEFTHPCDHEELREMLAHRT-LSKAKEQHTNRSFLLRMKCTLTSRGRTVNVKSASWKVLRCSGQIHT
TDGI-KKGVCEEKNVCSTYLVLICESIPHPAYIEAPLDSRTFLSRHTLDMRFTYCDERI-ELLGFEPGDLLQHSVYEYYHALDSDHMTKTHHNLFVKGQV
CTGQYRLLAKAGGFAWAETQATVIYNSKNSQPQCVVCVNYILSGIEQPKQILSLQQTNSTKMKQDHEEHH------------------------------
------------------------EES--NEKKEEC-E-ELCDS-------MTVA-----DLVLTLDITST--ALSVLTEIPLYNDVMLPSSSV--LLPL
SPLSPPCSSLN--T------HLD-------------DSSRSQVDFPVDSELSDQLKPDHVERLFSMDIESKTPFNTQGV-GLDLEMLAPYIPMDDDFQLR
VS-PAESMC----TP-------STQTAPALPGAP---LDIVSRDTVPQRTT---------EMIQDDESDISSKCQTTKLLKRKLETIPEAIRLGVLQ-T-
-FPEKKVRKSDS-RHATILVLPSDVASRLLSRSSEGM----PLPQLTRYVCEVNAPVTGRQHLLQGEELLCALDLVI--
>tr|F1QNB9|F1QNB9_DANRE Hypoxia-inducible factor 1 alpha A OS=Danio rerio GN=hif1aa PE=2 SV=2
----APG-KKRVSSERRKEKSRDAARCRRGKESEVFYELSRELPLPHSVTSNLDKASVMRLALSYLRLRKLLNSDVLE-K-ETALDTQWNGSFLKALDGF
LLVLSADGDIVYLSENVSKCLGLPQIELTGHSVFEFTHPCDHEELREMLAHRF-LSKSKDQNTNRSFLLRMKCTLTSRGRTVNVKSASWKVLRCSGRIHT
ADGV-EKEVCEEKNTCSTYLVLICESIPHPANIEAPLDSRTFLSRHTLDMRFTYCDERT-ELLGFDPEDVLQHSVYEYYHALDSDHMTKTHHSLFVKGQV
CTGQYRLLAKAGGFVWAETQATVIYNSKNSQAQCVVCVNYILSGIEQPKQILSLQQTNSTKIKQEEHQE-------------------------------
------------------------------KEDEEC-PVVQHNSLKGETEALTVA-----DPVLTLDINIT--AISVLTEIPLYNDVMLPSSDV--LLPL
SPLSPPCSSLN--G------HLQ-------------DSSRSQVDLPVDSELCDQLKPDHVEKHFSMDIESK----TQGV-GLDLEMLAPYIPMDDDFQLR
VS-PVRPMC----TP-------STQTSPALSAAT---PDSLSCDPVQQKTT---------EIIQD--SDISYKCQTPKLLKRKLETIPEAIRLGVLQ-T-
-FPEKKVRKTDA-RHATILLLPSNVASRLLSRSSEGM----PLPQITHHDCEVNAPVIGRQHLLQGEELLCALDLVI--
>tr|Q3S3U2|Q3S3U2_DICLA Hypoxia-inducible factor OS=Dicentrarchus labrax PE=2 SV=2
----VPETESRVSSERRKEKSRDAARCRRGKESEVFYELAQELPLPHSVSSSLDKASIMRLTISYLRMRKLLNTDEPM-KEETDLDLQLNSSYLKALEGF
LMVLSEDGDMIYLSENINKCLGLAQFDLTGHSVFDFIHPCDQDELREMLVHRT-GSKSKEPNTGRSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVHV
YDSHTEESTNGQKEPPIPYLVLICDPVPHPSNIEVPLDSKTFLSRHTMDMKFTYCDERT-ELMGYDPEDLLNRSVYEYYHAQDSDHLTKTHQNLFAKGQV
CTGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQIEDVKPVKAELQQG------------------------------
------------------------EEKLFTQAVAA-SLVSLYDRLKEEPEALTLLAPAPGDTIISLDFSCP--EIPMMNDVPVYNDVMLPSTSDKLALPL
SPLPPSEPLHV--Q------RYPTPAS---------PGSPLDFCFPMESDMSSDFKLDLVEKLFAIDTEPKTPFTTQAPEDFDLETLAPYIPMDDDFQLR
VT-PDEPLS----SP-------VTQDVHCY-----KSPGSRTASPAPPLAT---------TTQLDKEVSLSTLAAQ-TPRKRKLCDIK-----------Q
LEQGKKLKASES-TTTTILLLPSDLASRLLGSSSEGF----TLPQLTRDDCEVNAPLQGRQYLLQGEELLRALDHVN--
>tr|M9NZ78|M9NZ78_SPAAU Hypoxia inducible factor-1 alpha OS=Sparus aurata GN=HIF-1 PE=2 SV=1
----VPEK-KRVSSERRKEKSRDAARCRRGKESEVLYELAQELPLPHSVSSSLDKASIMRLTISYLRMRKLLSTDEPM-AEEKELDLQLNSSYLKALDGF
LMVLSEDGDMIYLSENINKCLGLAQFDLTGHSVFDFIHPCDQEELREMLVHRT-GSKAKETNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
YESHTEETPNGQKEPPVPYLVLICDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPEDLLNRSVYEYYHAQDSDHLTKTHHNLFAKGQV
CTGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQTEDVKPIKEEPQHD------------------------------
------------------------TDQLFTRVAEA-SVASLYDQLKEEPEALTLLAPAAGDTIISLDFSSP--EIQLLHDVPLYNDVMLPSISDKLVLPL
SPLPPSEPLHI--E------HYTSLAS---------TDSPMDFCFPMDSEMSSDFKLDLVEKLFAIDTEPKNPFTTQAMED--LEMLAPYIPMDDDFQLR
LP-PDEPLT----SP-------VKQDIPSYPSSPFSSPGSRTASPAPPLAT---------TTQLNKEVSLGTLAAL-TQRKRKLGDIK-----------Q
QEQGKKLKSSES-TT-R-TILPSDLASRLLGSTSEGF----TLPQLTRDDCEVNAPLQGRQYLLQGEELLRALDHIN--
>tr|Q2ESI1|Q2ESI1_MICUN Hypoxia-inducible factor 1 alpha OS=Micropogonias undulatus PE=2 SV=1
----VPEK-KRVSSERRKEKSRDAARCRRGKESEVFYELAQELPLPHSVSSSLDKASIMRLTISYLRMRKLLSTDEPI-AEETDLDFQLNGSYLKALDGF
FMVLSEDGDMIYLSENINKCLGLAQFDLTGHSVFDFTHPCDHEELREMLVHRT-GSKAKEPNTERSFFIRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
SDSCTEQTTSGQKEPPVPYLVLICDPIPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPDDLLNRSVYEYYHAQDSDHLTKTHHNLFAKGQV
CTGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQTEDVKPVKEELQPE------------------------------
------------------------EEELFTRAIES-TLVSLYDQLKEEPEALTLLAPAPGDTIVPLDFSCP--EIQ----LPLYNDVMLPSTSDKLALPL
SPLPPSEPLHV--E------RYPTTAS---------ADSPLDFCFPMDSDMSSDFKLDLVEKLFAIDTEPKTPFTTQAVEDLDLEMLAPYIPMDDDFQLR
LP-QEEPLS----SP-------VTQDIQSYPSSPFSSPGSRTASPAPPLAT---------TTQLGNEVSLRTLAAQ-SQRKRKLCDIK-----------E
LEQGKKLKASES-TT-TILLLPSDLASRLLGSTSENF----TLPQLTRDDCEVNAPLQGRQYLLQGEELLRALDHVI--
>tr|G3P0Z7|G3P0Z7_GASAC Uncharacterized protein OS=Gasterosteus aculeatus GN=hif-1a PE=4 SV=1
----VPEK-KRVSSERRKEKSRDAARCRRGKESEVFYELAQELPLPHSVTSGLDKASIMRLIISYLCMRKLLHNDEPV-TEETELESQINSAYLKALDGF
LLVLSEDGDMIYLSENVNKCLGMAQFDLTGQSVFDFIHPCDQEELREMLVHKT-GSKAKEADTKRSFFLRMKCTLTNRGRTVNVKSATWKVLHCSGHVRV
HDNPTEETSNGHKEPPAPYLVLICDPIQHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPEDLLDRSVYEYYHALDSDHLNKTHHNLFAKGQV
STGQYRMLAKRGGFVWVETQATIIYNNKNSQPQCVVCVNFVLRAIAEEKLILSMDQIEDVKPVTEELLQR------------------------------
------------------------AEKLFTRAAEV-SPASLYDQLKAEPEALTLLAPAAGDAVISLDFSCP--EILLVKEVPLYNDVMLPSTGDQLTPPL
SPLPLSETLRV--K------SYRSSAI---------ADSPLDFCYPMDSEMSSDFKLDLVERLFAIDTETKTPFTTQAMEDLDLEMLAPYIPMDDDFQLR
LT-PEESLS----SP-------VAQDIHSYPSSPFSAPGSRTASPAP-PAT---------IPQPDKEVSLMTLAAA-SQRKRKLGDAI-----------Q
VEQGKKLKASPS-TTRTIFLLPSDLASRLLGSTSDGF----TLPQLTRYDCEVNAPLQGRQSLLQGEELLCALDLVN--
>tr|D7R4L3|D7R4L3_9TELE Hypoxia-inducible factor 1 alpha OS=Callionymus valenciennei GN=HIF-1a PE=2 SV=1
----GPEK-KRVSSERRKEKSRDAARCRRGKESEVFFELAKQLPLPPGSSSSLDKASIMRLTISYLRMRKLLGSDKAK-EAGSELDLHFNSSYLKALEGF
LMVLSEDGDMIYVSDNVNKCLGLAQLDLAGHSVFNFTHPCDQEELRETLQHRA-GTKSRDVNSARSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHLYD
SE---------PSDGSVPYLVLICDPIPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPDELLNRSVYEYYHALDSNHLTKTHHNLFAKGQV
ITGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGVQEEQTILSLEQTQDVKSVKEEKAQE------------------------------
------------------------EESLLSPAQED-PPSSLYERLKEEPEGLTQLAPAAGDTIISLDFSCPE--VHIL-KDPLYNDVMLPSTSSKVALS-
---PPSEASAK--K------TFT-------------VVTSLDFCFPVDSDMNPDFKLDLVEKLFTINTQPKTPFASQPLGDLDLDMLAPYIPMDDDFQLR
LN-PDEPVR----SP-----------LHDYSSS----PASRTRSPEP-LAS---------TPQLDKEVSLRTLVAQ-AQRKRKLGELR-----------Q
VEAVKKLKPSDL---KTFILLPSDLASRLLGSTSDGL----SLPQLTRYDCEVNVPLQGRQYLLQGEELLRALDNVN--
>tr|Q2PMW1|Q2PMW1_ORYME Hypoxia-inducible factor 1 alpha OS=Oryzias melastigma PE=2 SV=1
----VPEK-KRVSSERRKEKSRDAARCRRGKESEVFYELATLLPLPHSVSSSLDKASVMRLTISYLRMRKLLGSDEPK-QEETELDMKFNSSYLKALDGF
LMVLSEDGDIIYLSENVNKCLGLAQFDLTGQNVFDYTHPCDQEELREMLVYRT-GSKAKEPNSERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVHV
NGVQAEQNSNGQKEPPVPYLVLICDPIPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPEDLLNRSIYEYYHALDSDHLTKTHHNLFAKGQV
CTGRYRMLAKSGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLIMSLDQIEDVKSVKEEPQEA------------------------------
------------------------DEAHFKKMAQS-PFDTLYDQLKEEPEALTLLAPAAGDTIISLDFSQPEPEIHLLKDAPLYNDVMLLSTSDKLALPL
SPLPPSEALSL--E------SPPTLI----------TDSSIDYCFPMDSEENSEFKLDLVEKMFAIDTESKTPFNTQ---DLDLEMLAPYISMDDDFQLP
VT-VEEPQP----SP-------VTKDALSYPTPQLNPLSGCTASPGPPLPA---------AGNLEKDVHPCSPAAP-TQRKRKLSDLM-----------E
LEKGKKLKPSEL-TTRTVLLVPSDLASRLLGTTSESF----TLPQLTRYDCEVNAPLQGRQYLLQGEELLRALDHVI--
>tr|I3KW40|I3KW40_ORENI Uncharacterized protein OS=Oreochromis niloticus GN=LOC100703737 PE=4 SV=1
----VPEKKSRATSERRKEKSRDAARCRRGKESEVFYELAQQLPLSHSVSSSLDKASIMRLTISYLRMRKLLSTDEPP-TEDAELDMQLNSSYLKALEGF
LMVLSEDGDMIYLSENVSKCLGLAQFDLTGHSVFDFTHPCDQEELREMLVHRT-GSKSKEPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCTGHVRV
YDSPAEEGTNGQKEPPVPYLVLICDPIPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-DLMGYDPEDLLDRSVYEYYHALDSDHLTKTHHNLFAKGQV
CTGQYRMLAKKGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSVKQTADVKPVKEEHQEE------------------------------
------------------------D-QILTDSAVT-LPVNLYDHLKGEPEALTMLAPAAGDTIVSLDFSCPESDIHLLKDVPLYNDVMLPSTDDKLVLPL
SPLPPSEPLNV--E------SYQTTTS---------PGSPLDFCFPMDSEMNSDFKLDLVEKLFAIDTEPKTPFNTQEMEDFDLEMLAPYIPMDDDFQLL
LP-PGEPLS----TP-----------IHSYPSSPFSAPGSRTASPAPPPPT---------APKLEKEVPLRTLAVQ-AQRKRKICDLK-----------Q
VEKGKKLKPSGS-TTRTIVLLSSDLASRLLGSTSEAF----GLPLLTRDDCEVNAPLQGRQYLLQGEELLRALDHIN--
>tr|A0A087XQT7|A0A087XQT7_POEFO Uncharacterized protein OS=Poecilia formosa PE=4 SV=2
----IPEK-KRVSSERRKEKSRDAARCRRGKESEVFYELSKQLPIPHSTSSNLDKASVMRLTISYLRMQKLLCIDEPV-AETTELDIQLNGSYLKALDGF
LVVLSEDGDIIYISENVNKCLGLAQFDLIGHSVFDFTHPCDQEELREMLVYRS-GSKVKEPSTERNFFLRMKCTLTSRGRTVNVKSATWKVLHCSGHVRV
HSS--EQSANGHKEPPVPYLVLICDPIPHPSNIEVPLDTKTFLSRHTMDMKFTYCDERT-ELMGYDPEDLLNRSVYEYYHALDSDYLTKTHHHLFAKGQV
TTGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNFVLSGIQEEKLILSLEQTQEMKPVKKEEEEE------------------------------
------------------------EQQFQDLVIKQ-EQDCLYNLLKGHPDALMLLAPAAGDTIISLDFSRPESETHLLKDVPLYNDVMLPSSGGKLPLPL
SPLAPTEPLEP--N------SFLKPPN---------VDNPLGFSFPMDTEMNSDFKLDLVEKLFAIDPEPKTPFNTEAMEDSELEMFAPYISMDDDFQLP
LG-PDEPLS----CP-------VTPELHSHPSSPFSAPESRTASPAPPPAT---------VAQPEKEVPLRNLAAQ-VQRKRKLSELK-----------Q
PEKGKKLKATEL-ATRTILLLPSDLASRLLGTTSDGL----SLPQLTSYDCEVNAPLQGRQYLLQGEELLRALDHVI--
>tr|H3DIY3|H3DIY3_TETNG Uncharacterized protein OS=Tetraodon nigroviridis PE=4 SV=1
----IVPEKKRVSSERRKEKSRDAARCRRGKESEVFYQLAQELPLPHSVSSSLDKASIMRLTISYLRMRILLNAGEPL-TEETDLDLQLNGCYLKALDGF
LMVLSEDGDMIYLSENISKCLGLAQFDLTGHSVFDFIHPCDQEELREMLIHRT-GSKAKEPNTERRFFLRMKCTLTSRGRTVNVKSATWKVLHCLGHVRV
HESPAEPDPDGAQPSAVPYLVLICDPIPHPANIEFPLDTKTFLSRHTMDMKFTYCDE-T-ELMGYDPEDLLNRSVYEYYHAQDSDHLTKTHHNLFAKGQV
CTGQYRMLAKRGGFVWLETQATVIYNTKNSQPQCVVCVNFVLSGVQEEKMILSLEQTADVKPVKEELVGS------------------------------
------------------------PADLLPEEADG-PLSSLYDHLKRRPGALTMLAPAAGDTVVPLDFSCP--ELQLLKEVPLYNDVMLPSTSDKLVLPL
SPLPPTGPLQV--K------HYSAAAS---------VDAPHDLCFCTDSDMSSDFKLDLVEKLFTIDTEPRTPLTTQAMEDLDLEMLAPYIPMDYDFQLR
LS-PDEALP----SS-------LSQEIHSYPSSPFSSAGSRTPSPAPPLAT---------TTQLNKEADLRMLAAQ-ATRKRKLGEVP-----------Q
MEQGKKLKAS---TTRTILLLSTDVATRLLGTTSEEF----SLPQLTRDDCEVNAPLQGRQYLLQGEELCAPWTTST--
>tr|H2U0Z2|H2U0Z2_TAKRU Uncharacterized protein OS=Takifugu rubripes GN=LOC101071027 PE=4 SV=1
----APEK-KRVSSERRKEKSRDAARCRRGKESEVFYQLAQELPLPHSISSSLDKASIMRLAISYLRMRKLLNAGEPI-TEETDLDLQLNGSYLKALDGF
LMVLSEDGDMIYLSENIIKCLGLAQFDLTGHSVFDFIHPCDQEELREMLIHRT-GSKAKEPNTERSFFLRMKCTLTSRGRTVNVKSATWKVLHCSGQVRV
YENHTEPSPDEQKESAVPYLVLICDPIPHPANIEFPLDTKTFLSRHTMDMKFTDCDERT-ELMGYEPEDLLNRSVYEYYHAQDSDHLAKTHHNLFAKGQV
CTGQYRMLAKRGGFVWLETQATVIYNTKNSQPQCVVCVNFVLSGIQEEKMVLSLEQTADVKPVKEELLQE------------------------------
------------------------E--MLTEVTES-PVSSLYDKLKEKPEALTLLAPAAGDTIISLDFSCP--EMQLLKEVPLYNDVMLPSTSEKLVLPL
SPLPPSEPLHV--K------RCSTPASSS-------VDGPHDLCFCMDSDMSSDFKLDLVEKLFTIDTEPKTPFTTQAMEDLDLEMLAPYISMDDDFQLR
LS-PDEALP----TS-------LTPEVPSYPGSPFSLPDSCTASPAPPLATS--------TTQLNKEVELRTLAAQ-TPRKRKLADVKRSQGVNLID-EQ
MEQGKKLKASDM-TTRTILLLPTDLATRLLGTTSEDF----SLPQLTRDDCEVNAPLQGRQFLLQGEELLRALDHVN--
>tr|A0A067Y838|A0A067Y838_BRAFL Hypoxia inducible factor alpha subunit long form OS=Branchiostoma floridae GN=Hifa PE=2 SV=1
----TLCRPKRRNSEKRKEKSRDAARVRRSKETEIFYELAHQLPLAHSKSAQLDKASIMRLAISYLKTRMIFADTEVV-KVESTTDQQMSDQYLKAMEGF
VLSLSDEGDILYLSENVCKYLGLTQLELTGHSIFDFTHPCDHEEIRDVLCTKN-----YTKNKACSFFMRMKCTLTSKGRNVNLKSATYKVIHCQGYLRS
YNNSQ-VNSLGCKEPPLLCLVAIGEPIPHPSNIEFPLDCKTFLSRHSMDMKFTYCDERITELLGHDPASLLGKGVYDYCHALDAERLERMHRCLYQKGQV
TTGQYRLLARRSGYAWVETQATIIYNNRTEKPQCIVCVNYVISDIEEEENVLSSEQASQKKFPKVEKIEE------------------------------
------------------------EPQFFW---------DGEQALRDSPEDLTRVAPAAGDAMIPLGFPSA-----------LFGSSSLPD----TSL--
DPGFGQEDLFG--SPFSSAGSSATPLSDD-------PNSDLDFMDQLMGRTTSDPDLTAINPSLALDTGPIAGKLTRPLTAEELSYRAPYIPAYQ--PLN
PN---NAV-TVTSTPDSCCG--QELPFAAYASPQMMTMNGKHLRVAKVGGS-----NRTRTHMPGKHGPIGKLTFAGSKRKKLDE-DIQQPDRGTEG--D
QPPAKKARVKAPNKIDVYKLL--NFD----DFDLDDD----FLPPLTRADVEVNAPIQT-YKLLQGNDLMSALDQSA--
>tr|V5IV31|V5IV31_BRABE Hypoxia-inducible factor 1-alpha isoform a OS=Branchiostoma belcheri tsingtauense PE=2 SV=1
----TVTRPKRRNSEKRKEKSRDAARVRRTKETEIFYDLAHQLPLAHSKSAQLDKASIMRLTISYLKTRMIFADTEGV-KVESSTDQQMSDQYLKAMDGF
VLSLSDEGDIMYLSENVCKYLGLTQLELTGHSIFDFTHPCDHEEIRDVLCTKN-----YTKNKACSFFMRMKCTLTSKGRNVNLKSATYKVIHCQGYLRS
YNNSQ-VNSMGCKEPPLLCLVAIGEPIPHPSNIEFPLDCKTFLSRHSMDMKFTYCDERITELLGHDPANLLGKGVYDYCHALDAERLERKHRCLYQKGQV
TTGPYRLLARRSGYAWVETQATIIYNNRTEKPQCIVCVNYVISDVEEEGTVLSSEQASQKRLPKVEKVED------------------------------
-------------------------VKFFW---------DGEQALRDSPEDLTRVAPAAGDAMIPLGFPSP-----------LFGSSVLPDSFEKTSL--
DPGFGQEDLFG--SPFSSSDSSV---GDE-------PSGDMDFMDQLMGRTGSNPDLTAINPSMALDTGPIACKLNRPLTAEKLSYRAPHIPSYE--PLI
PD---NSV-TFASTPNSCSG--GELPFAAYASPQMMTMNGKYLRVAKVGGQ--------ITHTPGKHGPVGKLTFAGSKRKELDEDDIQQPDRGTEG--N
QPPAKKARLKAPNKIDVYKLL--NFD----DFALDDD----CLPALKQTDIEVNIPMQT-CKLLQGNDLMSALDQSA--
>tr|A0A0P7UQ91|A0A0P7UQ91_9TELE Hypoxia-inducible factor 3a-like OS=Scleropages formosus GN=Z043_109809 PE=4 SV=1
MPPVSLSLGGRPSLEQRKVRSRDAARSRRSQETEVFYQLAHTLPFPRRVVSDLDKAAIMRVTLSFLRIHSLFHSGEVKVESAEEEEEAIDRFYPRALAGF
IMVLTEEGDMVFLSESVNKYVGITQLELLGQSVYDFVHPCDQEELRDVLTPRPGLSKKKDQRSERNFFLRMKSTLTNRGRVVNLKSAAWRVLRCSGHMRT
YHAADKT-----GPPIGNFLILLCEPIPDPSGVEFPLDCSAFLSRHSTDLRFIDCDDRVTQLVGYQPEDLTGRSAYEFHHALDSDHMTKSLHILFSKGQV
CTNQYRFLAKSGGYVWAETQATVTYNSKTSQPEAVVCLNFILSGVEHADVVFSMEQTPSLKKPKTEPEEKEE----------------------------
---------------------------------VGKGACAELLNLKELSEEVPQSSPTPGDVAVSKTESVEPKNLS------F----YRPPSPNTVPEFP
QELCTPDLRQLLSPIFDRP----E------------AASV----VSKCSGEDQFMDKDSVEKFFTFKPVDTNESTAEGTESMDLDMLAPYISMDDDFQLT
FFTQLPESDLSS--PESP--------------VPGAR--KR-------------YASCAKALEDDVET----SFRGILKDKRQRHTAVEEVLLAAKAPPE
PVPH-HNKLLTDGGVQELRDPPEFSQLSTNKRTFSRRP---PNNLCYGSATRITQLAVISPSYIQGEEYFVFGEG----
>tr|A0A0F8CNY0|A0A0F8CNY0_LARCR Hypoxia-inducible factor 1-alpha OS=Larimichthys crocea GN=EH28_08916 PE=4 SV=1
SSSSSSSSSCRTSSEQRKLRSRDAARCRRSQETEVFYELARTLPLPRRVSTHLDKSAIMRVSLSFLWLQRLLRPGGEKQKEEEEEGDPMDSFYPQALAGF
IMVMTEEGDMIYLTENVNRHIGITQLELLGQSIYDFVHPCDQEELRDLLTPRPGLSKKPEQPTERNFFLRMKSTLTSRGRTVNIKSATWKVLHCTGHVRP
FGGG-ST-----SPPAARVMTLLCEPIPHPSSVEFPLDTCTFLTRHSMDLRFTHCEGRVTELVGYKPDDLIGRSAYEFHHALDSDHVNKSLHTLLSKGQV
NTSHYRFLANSGGFVWAETQATVLYSSKTSQPEAVVCLNFILSAVEQPDVVFSVEQIRCGQAKTHTPAECG-----------------------------
----------------------------------SSSSADLFLKLKEQPGELLQLAPEAGDVIVPLT---DFVELS------F----FSGSSPDSVPDHP
QDLCTPQLRQLLSPIFNPI----S------------PPVSLLLDPEPSSPSEEVMDTSEVEKFFAICPEDVQGDAKDDMEGMDLEMLAPYISMDDDFQLT
FLSGLPEESDKP--SSES--------------SAGTS--AV-------------PLSRKRTHIPDEEL----LSHLMIQDKRQKQSSIEELLLSRLLQSD
PRPGGRSRLLTDGGIQGLCDTAALMRDIFLS------P---PLSPMT--------------------------------
>tr|A0A060WKF5|A0A060WKF5_ONCMY Uncharacterized protein OS=Oncorhynchus mykiss GN=GSONMT00028434001 PE=4 SV=1
MDTKEEPVGKRSSTDQRKVRSRDAARCRRSLETELFYKLAHTLPLPRRVSADLDKAAIMRVTLSFLRMHHLRSG-DTSEDVTDGDEDTVDAFYPRALAGF
ILVMTEEGDMIYLGDSVSKHLGIPQLELLGQSVYDFVHPCDQEELRELLAPRPGVSKKKQQHTEINFFLRMKSTLTSRGRTVNIKSATWKVLHCTGHMRV
CCSGEDS-----SPPAGSFMTVLCEPIPHPSSVEFPLDRSTFLTRHSMDLCFTHCDGRVSELVGYEPEDLIGKSAYKFHHALDSDHVTKSLHILLSKGQV
CTSLYRFLAKSGGFVWAETQATVIYNNKTSQPEAVVCLNFILSVVEQADVVFSVEQTGCGLKSDPVSEASE-----------------------------
----------------------------------NSSSAELSLQLKENQEDLLQLAPVSGDPIVPLT---DFAEPS------F----SLPSSSDSAPDFP
QELCTPELWKLLSPIFSKL----T------------SSAPAL-VRTLIPIEELPIE-DEVAKLFAVCPDESVRNQPEDMEVVDLDMLAPYISMDDDFLLS
V--QLPETPDSP--SPEP--------------P---------------------TATRKRSHEQDEDM----PSQLMSQDKRPRHSPIHKLLLSALLNPG
SIPHRRSQLLTDGEAQGLCDTAALMRDLFPLTSSLT-------------------------------------------
>tr|H3CMV6|H3CMV6_TETNG Uncharacterized protein OS=Tetraodon nigroviridis PE=4 SV=1
---QVNEQRFRGSTEQRKLRSRDAARYRRSQETEVFYELAHTLPLPRRVSTHLDKSAIMRVSLSFLRMRKLLQTADGDKR-ESEEDDPMDGFYPQTLAGF
IMVLTEEGDMIFLTENVNKYIGIVQLELLGQSIYDFVHPCDQEELTDLLAPRPGLNKKQEMPSDINFFLRMKSTLTARGRTVNIKSAEWKVLHCTGHMCP
FDAE-VS-----S--AARVMVLLCEPIPHPSSVEFPLDTYTFLTRHSMDLRFTHCEGRVTELVGYKPDDLIGRSAFEFHHALDSDHISRSLRTLLSKGQV
STSRYRFLANHGGFVWAETQATVLYNGKTSQPEAIVCLNFILSSVEQPDVVFSVEQVHCDRSEASSPA--------------------------------
----------------------------------PSSSAELCFEPEEKPEQLLQLAPEAGD-VVPLT--E-VAELS------F----LSPSSPNMVPENP
QDLCSPQLLQLLTPIFSPM----T------------PPPSSPSE---SDAEPELMDTSKVEKFFTFWSKDGQREKLKDTEEMDLEMLAPYISMDDDFQLT
FLGTLSEEEDKN--PANL--------------SPLST--AL-------------TANNKRSHNPDEEE----VSDLLSQAKRHRKSSMEELLNYYHLPAD
PERGGRSQLLTDGGLQGLSDTAAWMKDIFLS------P---PVSLLT--------------------------------
>tr|G3PIK9|G3PIK9_GASAC Uncharacterized protein OS=Gasterosteus aculeatus PE=4 SV=1
EEKAETVVVKRTSSEQRKLRSRDAARCRRSQETEVFYELSSTLPLPRRVCTHLDKSAIMRVALSFLRMHHFLLQPGEKRVSSSPMEPPMDSFYPQALAGF
IMVMTEEGDMIYLTENVSTHIGIPQLELLGQSIYDFVHPCDQEELRDLLTPRPGSTKKPRQSSERNFFLRMKSTLTSRGRTVNIKSAAWKVLHCTGHVRQ
LGGA-SA-----VPPVGGVMTLLCEPIPHPSSVEFPLDTRTFLTRHSMDLHFTHCEGRVTELVGYKPEDLIGRSAYEFHHALDSDHVNKSLHTLLSKGQV
STRHYRFLANGGGFVWAETQATVLYNSKTSQPEAVVCLNYILSGVEQPDLVLSAEQTRCVRPHEAELCTPAV----------------------------
---------------------------------APSSAAVLVFKLKEESEEVLQLAPEVVNPIGPLT--GEFVGLS------F----SNPPSPNSLPDHP
QDLCTSQLRQLLSPIFSPM----T------------PPSSSSLDVESISCEEEVTDTSEVERFFAVWPDGQKVEPMEQMEVMDLEMLAPYISMDDDFQLT
VHSSFPEDVDKP--PSSP--------------SESSV--VAMA----------ATVSRKRAHNPDEEI----LSQLMVQDKRPKHPSIEELLLNRLLQSS
PVAEGRSQLLTDGGIQ---------------------------------------------------------------
>tr|H2L9F9|H2L9F9_ORYLA Uncharacterized protein OS=Oryzias latipes GN=LOC101165163 PE=4 SV=1
EKEDETVAVKRTSSEQRKLRSRDAARCRRSQETEVFYELARTLPLPRKVCTHLDKAGIMRVTLSFLRMQQLLQPHEAGKETFNKKETPMDAFYPQALAGF
VMVMTEEGDMIFLTENVNKHIGITQLELLGQSIYDFVHPCDQEELRDLLTPRPGLSKKSEQPNEVNFFLRMKSTLTNRGRTVNIKSATWKVLHCSGHIRP
FS-G-SA-----APPGARVMTLLCEPIPHPSSVEFPLDTCTFLTRHSMDLRFTHCEGRVTELVGYKPEDLVGRSAYEFYHALDSDHMKKSLHTLLSKGQV
STSHYRFLANNGGFVWAETQATVLYSSKTSQPEAIVCLNFILSSVEQPDVVFSVEQTRSGLLSKTESP---N----------------------------
---------------------------------TPSSSARLFLKLKEEPEEILQLAPES-GDAVVLV--AAPVELS------F----SSPLSPDSVPDHP
QELCTPQLRQLLSPIFDTL----T------------PSSSPESA--LSAAQEEVMDIGEVERFFALCPEDVQTQTLENVEEMDLDMLAPYISMDDDFQLT
LLNTLPEESIQA--ASES--------------STRKR--VNQVV--------YADRVSFRTFESDDEM----LPQLLIQEKRQKQ---EELLLTRLLQTE
SSPGKCSQLLTDGGIQSLCDTAGLMRDVFLS------P---PLSPMT--------------------------------
>tr|H2T9X1|H2T9X1_TAKRU Uncharacterized protein OS=Takifugu rubripes GN=LOC101062698 PE=4 SV=1
EEKEESISIKRSSSEQRKLRSRDAARYRRSQETEVFYELAHTLPLPRRVSTHLDKSAIMRVALSVLRMRQLVQAASESQK-KEPEEDPMDIFYPQTLGGF
IMVLTEEGDMIYLTENVNKYIGIVQLELLGQSVYDFIHPCDQEELTDLLTPRPGLNKKLDLPNDLNFFLRMKSTLTNRGRTVNIKSAEWKVLHCTGHMCP
FGGE-PS-----SPAAARVMVLLCEPIPHPSSVEFPLDTYTFLTRHSMDLRFTHCEGRVTELVGYKPDDLIGRSAFEFHHALDSDHISKSLRTVLSKGQV
STRHYRFLANNGGFVWAETQATVLYSGKTSQPEAIVCLNFILSSVEQPEFVFSIEQVHSDPPEANVPALAP-----------------------------
----------------------------------SSNAADLFFKLKEKPQELLQLAPEAGD-VVPLT--ADFSKLS------F----FSPSSPDTMPENP
QDLCSPQLLQLLTPIFSPM----T------------PPSSSTDAELPQSASEEVMDTSKVEKFFTIRPENSQGEKLKDSEEMDLAMLAPYISMDDDFQLT
FLSSLSEEEDKR--SAPL--------------RTLSA--AL-------------AANRKRSHNPDEDE----ASDLLIEDKRQKKSCIEELLNYYNLQPS
AEGGGSSRLLTDGGMQGLSDTAAWMKDIFLS------P---PASPLT--------------------------------
>tr|Q5IGQ1|Q5IGQ1_EPICO Hypoxia-inducible factor 4 alpha OS=Epinephelus coioides GN=HIF-4a PE=2 SV=1
EEKEEAVAVRRTSSEQRKLRSRDAARCRRSQESEVFYELAHTLPLPRRVCSHLDKSAIIRAAISFLRMHHLL-QPGEKQKESNEEEDPMDAFYPQALAGF
IMVMTEEGDMTYLTENVSRYIGITQLELLGQSIYDFVHPCDQEELRDLMAPRPGLSKKPQQQNERNFFLRMKSTLTSRGRTVNIKSAAWKVLHCTGYIHQ
FDGS-SR-----LSPAGRVMTLLCEPIPHPSSVEFPLGTCTFLTRHSMDLCFTHCEGRVTELVGYKPEDLIGRSAYEFHHALDSDHVNKSLHTLLSKGQV
STRHYRFLANSGGFVWAETQATVLYSSKMSKPKAVVCLNFVLSAVEQADVVFSMEQVRRGQPAEAEPLSPAL----------------------------
---------------------------------APSNSAELSFKLKEQPEELLQLAPAAGDIIVPLS--GENFELS------F----TRPVSPKSVPDNP
QDLCTPQLRKLLSPIFSPI----T------------PPSSSQNP-KRSPCEDEVLDNGEVDSFLAVWREVFQGQTLEDMEEMDLEMVAPYISMDDDFQLT
VLSSLPEEADKP--LLSW--------------PEPSS--VSRA----------ITVSRKRCHNQDNEM----LSQLMIQEKRQKHSSFEELLLSRLLRSE
PVPGKQTKLLTDQGIQGLGDSAAVMRNIFLS------P---TLSPIT--------------------------------
>tr|I3JLN1|I3JLN1_ORENI Uncharacterized protein OS=Oreochromis niloticus GN=LOC100708832 PE=4 SV=1
EKKEGVVAVKRTSSEQRKLRSRDAARCRRSQETEVFYELAHTLPLPRRVSTHLDKAAIMRVTLSFLRMHHLLRSDKNLKEEEEKDEDPMDAFYPQALAGF
IMVMTEEGDMIYLTENVNKHIGITQLELLGQSIYDFVHPCDQEELRDLLTPRPGLSKKSEQTSERNFFVRMKSTLTTRGRTVNIKSATWKVLHCTGQIRP
FGSG-SA-----SPPAGRVMTLLCEPIPHPSSVEFPLDTCTFLTRHSMDLRFTHCEGRVAELVGYKPDDLIGRSGFEFLHALDSDHINKSLHTLLSKGQV
STSQYRFLANNGGYVWAETQATVLYNSKTSQPDAIVCLNFILSSVEQPDVIFSMEQTRCSRVPKIEPADEDS----------------------------
----------------------------------SSSSAKLFMELREKPEELLQLAPDAGDTIVPLS--PGSVELS------F----ASPPSPDSVPEHP
RDLCTPQLRKLLAPIFDPI----T------------PPPSASPEPEQSRSEEEVMDTSEVEKFFAFWPEDAQD-TLVEMEGMDLDMLAPYISMDDDFQLT
FLSSMTEEAEKP--SSSE--------------SSA--------------------TSRKRTHDSAEEM----LSTVMLQDKRPKKPSIEELLLTKLLQPD
PVPESRSHLLTDGGMQGLCDTAALMKDIFLS------P---PLSPMT--------------------------------
>tr|Q6STN7|Q6STN7_CTEID Hypoxia-inducible factor-1alpha OS=Ctenopharyngodon idella GN=hif-1alpha PE=2 SV=1
MDTGVVTEKKRVSSERRKEKSRDAARSRRGKESEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLLSSDDTDKE--NELEGQLNGFYLKALEGF
LMVLSEDGDMVYLSENVSKSMGLTQFDLTGHSVFEFSHPCDHEELREMLVHRTVSKKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCAGHVRV
QERSEGS---------LTYLVLICDPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGYEPDDLLNRSVYEYYHALDSDHLTKTHHNLFAKGQA
TTGQYHMMAKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDIVLSLQQTMTEPKAVEKESQKVE----------------------------
---------------------------------DPMECSDLYEQLKEEPEALTVLAPAAGDTIISLDFNNSDSDMQ------LVKDVMLPSSSEKLPISL
SALTTPALSKLETRAEDFPFSANT------------PSTSGLMDYQVDSDISSEFKLDLVEKLFAIDTEAK-PFTNQAIEDLDLEMLAPYIPMDDDFQLR
VPSPLDPLPSSS--LS-V--------------SAMSS--LFQPL--------PSPASVKKEPSSRPKM----LAIQNVQRKRKLETSLEAVGLGLLQSVA
IEPGKRAKVLEVGGNRTILILPSDVASRLLCSSLESSG---GLPQLTRYDCEVNAPVQDRHHLLQGEELLRALDQ----
>tr|E9KYT2|E9KYT2_CARAU Hypoxia-inducible factor-1alpha (Fragment) OS=Carassius auratus PE=2 SV=1
---------------------------GDPLEIEVFYELAHQLPLPHNVTSHLDKASIMRLTISYLRMRKLLSSDQSEKE--NEEESQLNSFYLKALEGF
LMVLSEDGDMVYLSENVSKSMGLSQFDLTGHSIFEFSHPCDHEELREMLVYRTGSKKTKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVRV
QECDEGS---------LTYLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELMGYEPDDLLNKSVYEYYHALDSDHLTKTHHNLFAKGQA
TTGQYRMLAKKGGFVWVETQATVIYNPKNSQPQCIVCVNYVLSGIVEGDVVLSLQQTMTEPKAEEKENQEME----------------------------
---------------------------------EPVMSSELYEKLKEEPEALNVLAPSAGDTIISLDFNNSDSDMQ------LLKDVMLPSSSEKLPISL
SPLTTPVLTKLETGAEDFPFCTNS------------SSTSGLMEYQVDSDISSEFKLDLVEKLFAIDTEAK-PFSPQAMEDLDLEMLAPYIPMDDDFQLH
IPSSLDPLPSGP---HSV--------------SAMSS--LFQPL--------PSPASMKQEPSSRPKM----LAIQNAQRKRKLETSLEAVGLGLLQSVV
VEPGKRAKVLEVGGNKTILILPSDVASRLLCSSLESSH---GLPQLTRYDCEVNA------------------------
>tr|M3ZLV4|M3ZLV4_XIPMA Uncharacterized protein OS=Xiphophorus maculatus PE=4 SV=1
DTEHNFLLHQMSSSEQRKLRSRDAARCRRSQETEVFYELARTLPLPRRVCTHLDKAGIMRVTLSFLRMQQLLQPEESVKK---EDEDPMDAFFPQALAGF
VMVMTEEGDMVFLTENVNKHIGITQLELLGQSVYDFIHPCDQEELRDLLTPRPGLSKKLEQPSERNFFLRMKSTLTSRGRTVNIKSATWKVLHCTGHIRP
F--G-SA-----SPPAARVMTLLCEPIPHPSSVEFPLDSSTFLTRHTMDLRFTHCEGRVTELVGYKPEDLIGRSAYEFYHALDSDRIKKSLLTLLSKGQV
NSSPYRFLANCGGFVWAETQATVLYS-KTSQPEAIVCLNFILSAVEQPDVVFSVEQTRCSLLPKTEPSSPER----------------------------
---------------------------------AAGSSAKLLLKLTEKPEELLQLPDGGDGVAPALT--AGRVELS------F----ASPPSPDVVPDHP
KDLCSPQLRQLLSPIFDGL----N------------PSSSPASEPDLSPCEEEVMDTSEVERFFTICPEETQEQAIEDVEGKELEMYAPYISMDDDFQLT
FLSNLPQEANKP--ASLL--------------FQGTD--GIPA----------VTVSRKRTHDLDKEP----PPLLMIQDKRHKPSSIEELLLSRLLQPD
SR---RSQLLTDS---ELCDTAVLMRDIFLS------P---PLSPMT--------------------------------
>tr|A0A0R4IBR4|A0A0R4IBR4_DANRE Uncharacterized protein OS=Danio rerio GN=hif1al PE=4 SV=1
---MVNSTSKRPSLEQRKVRSRDAARCRRSQETEVFYELAHSLPLPRRIASHLDKAAIMRVTLSYLRMNRLIQS-GSTK-QTEKSETPTDGFYQQALAGF
ILVMTEEGDMVFLSESVSKYIGITQLELLGQSVYEFVHPCDQEELRDILATRPGVSKKK---MEHNFFLRMKSTLTHTGRTVNIKSATWKVLHCTGHMQP
FSGDDEN-----SPSAGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHNLDLTYTQCDGRVTELVGYQPDDLIGRSAFEFFHALDFDHVSRSLHILFSKGQV
CTGQYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEQDVVFSLEQTCEKPKPKVERLMVLK----------------------------
---------------------------------EESSTAKLFLQMKENPEELLQLAPHSGDAIISLT---EGLELS------F----CCPQSPNSVPECP
QDFCTPELRKLLSPIFDGP----A------------KSHPA--A---SPAEELPMEMEGVEKFFALKPEESLKGQSEAVDELDLDMLAPYISMDDDFQLT
FLPQSE--ITPP--LEML--------------T---------------------SNSRKRCLEDDDDI----PVLAA--RWDKKQGPIDQLLLSTLLGSE
PPPQKRSQLLTDGGVQALCDTAALMRDTFLRRPVGE-----TLPSLT--------------------------------
>tr|Q1L607|Q1L607_ICTPU Hypoxia induced factor-like factor OS=Ictalurus punctatus PE=2 SV=1
---MTTTEVKRPSSEQRKVRLRDAARCRRSQETEVFYELAHSLPLSRRITSHLDKAGIMRVTLSYLRMRHLLHSSWTKAA--EEEEDPTDAFYQQALAGF
ILVLNEDGDMVFLSDNVNKFIGITQLELLGQSVYEYVHPCDQEELRDLLTTKPGLFKKKDSCTECNFFLRLKSTLTSRGKTVNIKSATWKVVHCTGRMKT
LNQEGEG-----SSPVGSYMTLLCEPIPHPSCVEFPLDSSTFLTRHNMDLHFIQCDGRVTELVGYHPNDLIGRSAYDFIHALDFDHLTRSLHVLLSKGQV
CTYHYRFWLVNGGFVWTETHVHVLYNSRTSQPEAVVCLNFILSAVEEADTVFSVEQTRSEVNQDEPN--VIE----------------------------
---------------------------------V-SSSSELFHRFKNDPEDLLQLAPAPGDTIIPLT---VNTELF------F----CPPSSPTTVPKCP
KELCTPKLRQLLSPIFDSS----C------------PSSPD--L---SSADEVPMDTGEVEKFFANKPEET-KEPVQELDDMDLDMLAPYISMDEDFQLT
FLPQLPEAETQA--AEAP--------------S---------------------TASKKRGLE-KDDM----PSLTS--KWEKRLCPIEEFLLTSSLDLD
PERWKQSQLLTDGGTQALCDTAALMPDSFLMARLTG-----TISLV---------------------------------
>tr|T1Q076|T1Q076_SCHPR Hypoxia-inducible factor 3 alpha subunit OS=Schizothorax prenanti PE=2 SV=1
---MVNSAMK--GLEQRKVRSRDAARCRRSQETEVFYELAHSLPLPRRIASHLDKAAIMRVALSYLRMNRLIQSAGPTK-PTEETENPTDAFYQQALAGF
ILVMTEEGDIVFLSESVSKYIGITQLELLGQSVYEFVHPCDQEELRDILATRPGVSKKKEKLTKHNFFLRMKSTLTHTGRTVNLKSATWKVLHCTGHMQT
FSGDGEN-----EPPAGSFLTLLCEPIPHPSSVEFLLDSSTFLTRHNMDLSFTQCDGRVTELVGYQPDDLIGRSAYEFYHALDFDHVTRSLHILFSKGQV
CTSHYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLYFILSGVEEADVVFSLEQTCEKPKPRAEKLSVPK----------------------------
---------------------------------EESSAANLFLQMKENPEELLQLAPHSGDDVISLT---DCVELS------F----CCPSSPTTVPECP
QDFCTPELRELLSPIFDRP----T------------KSPPA--A---SPAEELPMEMDGVEKFFALKPEESVKRQSEAMDELDLDMLAPYISMDDDFQLT
LLPQGE--MVAP--SDML--------------T---------------------KTSRKRCLEDEDDI----PVLAA--KWEKKPGSIEQFLLSTLLGSE
QPPQKRSQLLTDGGVQALCDTAALMRDTFK-RPVAE-----TMPSLT--------------------------------
>tr|V9P0R0|V9P0R0_CLABA Hypoxia induced factor 3 alpha OS=Clarias batrachus GN=HIF-3 alpha PE=2 SV=1
---MTTTVAKRPSSEQRKVRLRDAARCRRSQETEVFYELAHSLPLSRRITSHLDKAGIMRVTLSYLRMRHLLHSSWTKVSTLEEEEEPTDAFYQQALAGF
ILVLSEEGDMVFLSENVNKFIGITQLELLGQCVYDYVHPCDQEELKDLLTTKPGLFKKKESCTECNFFLRLKSTLTSRGKTVNIKSATWKVVHCTGYMKT
LNQEGEA-----SSLAVSYMTLLCEPIPHPSCVEFPLDSSTFLTRHTMDLHFSQCDGRVTELVGYHPNDLIGRSAYDFFHALDFDHLTRCLHVLLSKGQV
CTSRYRFLAKNGGFVWTETQATVLYNSKTSQPEAVVCLNFILSAVEEADVVFSIEQTRSDLMQDKLS--VIE----------------------------
---------------------------------V--SSSELYHSLKDDPEDLLQLAPAPGDTIIPLT---GHTELF------F----VPPSSPNSVPKCP
KELCTPKLRQLLSPIFDSS----C------------PTSPD--H---SSGDEFSMDTGEVEKFFADKPEET-KKTMEDMDDLDLDMLAPYISMDEDFQLT
FLPKLPEADTQT--PEAQ--------------T---------------------TASKKRALD-EDDM----PSLTS--NWEKRRCPIDEFLLSSSLGLD
PDRWKPSQLLTDGATKALCYTAALMRNSFLMAQLTG-----TISPLA--------------------------------
>tr|G4WI70|G4WI70_MYXAS Hypoxia-inducible factor 3a OS=Myxocyprinus asiaticus GN=HIF-3a PE=2 SV=1
---MVNSSGKRPSLEQRKVRSRDAARCRRSQETDVFYELAHSLPLPRRIASHLDKAAIMRVTLSYLRMNRLIQSGSTKT-SHEETEDPTDGFYQQALAGF
VMVMTEEGDMVFLSESVGKYIGITQLELLGQSVYEFVHPCDQEELRDILTTRPGLSKKKVKLTEHNFFLRMKSTLMHTGRTVNIKSATWKVLHCTGHIQT
LSSEDES-----STPGGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHNMDLTFTQCDGRVTELVGYEPDDLIGRSAYEFYHALDFDHVTSSLHILFSKGQV
CTSHYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEQADVVFSLEQTSDKPLPKAVKLSLLE----------------------------
---------------------------------EVSSTAELFLQMKENPEELLQLAPHSGDTIISLT---EGVDLS------F----GRPTSLNGIPECP
QDFCTPELRQLLSPIFDKP----S------------NSPHA--A---SPAEELPVEMDGVEKFFALKPAESVKGQTENMDELDLDMLAPYISMDDDFQLT
FLPQCPETVTSS--PEML--------------T---------------------NTSRKRCLEDDDDI----PALAA--KLEKRESSIERLLLSTLLGTE
PPPQKRSQLLTDGGVQALCDTAALMRDTFLLRPVAE-----TTSTLT--------------------------------
>tr|W5KMK5|W5KMK5_ASTMX Uncharacterized protein OS=Astyanax mexicanus PE=4 SV=1
----MESSPKRPSSDLRKVRSRDAARCRRSQETEVFYELAHSLPLARRVTSHLDKAGIMRVTLSYLRMRQLLCSSTTKVEGTEEEQDPTDAFYQQALSGF
VLVLTEEGDMIFLSENVSKYIGLAQLELLGQSVYDFVHPCDQEELRDILTSKTGLCKKKEKFIEHNFFLRMKSTLTSRGRTVNIKSAAWKVLHCTGHMQT
FSSELES-----SSATGSYLTLLCEPIPHPSCVEFPLDSSTFLSRHSMDLNFTQCDGRVTELVGYHPDELVGRSAYEFFHALDFDHVTKSLHILFSKGQV
CTSQYRFLAKNGGFVWIETQATVIYSSKTSQPEAVVCLNFILSGVEQAETVFSVEQTRCELKSEKPSLPVIK----------------------------
---------------------------------VSSSSAELFRKLKDNPEDLLQLAPAAEDTIILLT---EEMDLS------F----GPPSSPNGVPECP
KDLCSPKLRQLLSPIFDSP----S------------PASPA--S---NSGDELSMDTGDVEKFFAIKPEENTKELTKELEEMDLDMLAPYISMDDDFQLT
FLPQFSETKLSS--SEEP--------------A---------------------APSRKRGLE-DEDL----PSLTT--TWEKRQCSIDELLLSSSLASN
TSPWRKNLLLTDGEPQLLCNTADLIKNSFLRSQTAG-----TLLPHT--------------------------------
>tr|Q6STN6|Q6STN6_CTEID Hypoxia-inducible factor-4alpha OS=Ctenopharyngodon idella GN=hif-4alpha PE=2 SV=1
---MVNSVNKRPSLEQQKVRSRDAARCRRSQETEVFYELAHSLPLPRRITSHLDKAAIMRVTLSYLRMNRLIQSVGPTK-KTEETENPTDGFYQQALAGF
ILVMTEEGDMIFLSESVSKYIGITQLELLGQSVYEFVHPCDQEELRDILTTRPGISKKKEKLAEHNFFLRMKSTLTHTGRTVNMKSANWKVLHCTGHMQT
FSGDDET-----SLPAGSFLTLLCEPIPHPSSVEFPLDSSTFLTRHSMDLTFTQCDGRVTELVGYQPDDLIGRSAYEFYHALDFDHVTRSLHILFSKGQV
CTSHYRFLAKNGGFVWTETQATVLYNSRTSQPEAVVCLNFILSGVEEADVVFSLEQTCQKPKPKAEKLTVLE----------------------------
---------------------------------EESSTATLFLKIKENPEELMQLAPHSGDTIISLR---EGVELS------F----CQPPSPNSVPECP
QDFCTPELRQLLSPIFDRP----T------------KSPPA--A---SPAEELPMEMEGVEKFFALKPEESVKGQSEAMDELDLDMLAPYISMDDDFQLT
FLPQSE--MAAS--SEML--------------T---------------------NTSRKRCLEDEDDI----PVLAA--KWEKKQSSIEQLLLSTLLASE
PPPQKRCQLLTDGGAQALCDTAALMKDTFLMRPVAE-----TMPITSE--T----------------------------
>tr|K1QJG7|K1QJG7_CRAGI Hypoxia-inducible factor 1 alpha OS=Crassostrea gigas GN=CGI_10017861 PE=4 SV=1
------DDPRNGNSEKRKEKSRDAARCRRGRETEIFSELAEQIPQYSGSNGQLDKASIMRLAISYLKISQIMETQRNNR---HAPCEEFDSLYSKALDGF
VVILSNEGDLIYISESVSKYLGIQQVDLVGQSIYEFVHPCDHEDITDIFHSNGDKKKKKSEEFHHTFFVRMKCTLTNKGKNVNLKSATYKVIKFSGKLVK
DKI---KKECGG-EGNAPYLLLIGEPIPHPSNIEIPLDQMTFLSRHNMDMKFTYCDDRVKDLLGYNCSDLMNKSLFDYHHAMDSEVIDQAYKNLIAKGQV
MTRHG---------------------------------------IENPSLILSTAQQVPMLPLEVKLSTE------------------------------
------DVFKP-----RPDNVKVDEF-YFPP-G--VKMP---SMKMDETVDLTHLAPTSGDTCVPLIGDDC----------------VQFS-------PD
QPMPALKEEP---DMFSARICSHSPL-ATPPSVSPAPISPMDYTTPLTP-----SVVDAMDKFFSVETYQRN---DQATADLDMDMRAPYIPMNKDFSLL
PPTSDALFT-I--NSDF------NP-----------GLFGRTESVFVPKEPRMSIRLVGSTAVASIEQPPDTF---NLQLKRPLDMNSLEKGP-------
-PSKKRFIQDYQEPKKHSVLMPTGVRKPQQH-QAK-P----YFPAMGHRDSLSGVIETP-DLLLQNPDLLAALELF---
>tr|A0A0B6YT30|A0A0B6YT30_9EUPU Uncharacterized protein OS=Arion vulgaris GN=ORF35837 PE=4 SV=1
------AKDKRRNTEKRKEKSRDAARCRRGKETEVFMELANCLPVPESVFSQLDKASIMRISISMLKIFNILQSDSNND---SAKIDKFDHLYQKALEGF
AFILAQEGDIVYLSESVARYLGLQQIELVGQSVFDFTHPCDHDEIKEVLAIKQQQQLI--SSDTRNFFMRMKCTLTAKGRNANLKSATYKVLKCTGRVIT
KKGSGSQDQCQV-QTTLHYLVGIAEPIPHPVNIEVPLDSKTFLSKHSMDMHFIFCDERIKELAGYDCEGMIGQSLYDFHHALDSEVIDKAFKDLFSKGQT
VTGSYRFLARHGGYIWVVTQATIINNSRSQKPQWVVCVHYVLSGIEDNGTILSHIQCPDLLNTKVELNTE------------------------------
------NIFAP-----KTKDMEQ--G-YMKPSE--IKGSI--MFHDKDPEDLSYLAPNAGDELIPLTFNIL----------------LSPS-------H-
----ALKQEP---GTSTPDMCYRSPASALSSNSSSRIASPNDYMSM--A-----VDVESMDKFFQIKTS---E-EDGDAEDIDFDMRAPYIPMDGDLGLL
PPSSSVLFN-L--SSEI------NP-----------RLFGLTESVFGPKPIKLSVRLGGSTAVASIEQPPDTM---YLQLKRPLDMNSLEKGP-------
-PRSKIVRLNPQDNSSSSVLLNYGVSNMLLD-PIK-T----CLPNLTRQDCEVNAPTQA-AHLLQGQELLQALEGI---
>tr|M1K779|M1K779_HALDV Hypoxia inducible factor-1alpha OS=Haliotis diversicolor PE=2 SV=1
------SKDKKRNSDKRKEKSRDAARCRRSKETEVFYELAQNLPLPSSVSTQLDKASIMRLTISFLKICKIREEKKWHD---DDIQKRLHQMYPKALEGF
VLILSREADIVYLSENTAKFLGIQQIELMGQSIFDFTHPCDHEEIRDMMSDRPGSK-A--VSEERTLFIRMKCTLTSKGKSVNLKSATYKVIKCTGRLVV
AKKSKKD--SDD-ASMYPYLLAVGEPIPHPANIEAPLDSSTFLSKHNMNMSFTYCDDRIQDLIGYNNDNLIGKSLYNYHHALDSEIVEKAFKDLFAKGQT
MTGQYRFLAKNGGYAWVITQGTIIYNNRTQKPQWVVCVHYVLSAIQEKNMILSEVQQQDLLSFKMEQSTD------------------------------
------KIFGP-----RTKDMEQ--N-YFVPEE--LKNNI--TLVNNEPADLSYLAPTAGDGCVQLGFPDF----------------ACMD-------KD
LPPPMCKEEP---DPVPRDVHRNNSNNPSPASLSPRIQSPDEYQTIASP-----TDVDLMDKFFSMDTTQKGS-SDSDMEDVDLNMRAPYIPMNADFSLV
PPSTDSLFS-L--QNDF------NP-----------GLFGRTESVFMDKPMQPSVRIGGSTVVASIEQPPDTM---LLQVKRPLDMNSLEKGP-------
-PVAKVVKRNDEGLSKESVLLNHGVNSSLQ--RMH-G----FFTDLTRQDCEVNAPTQS-HHLLQGEDLRAALDAD---