>seq_1
MSPRLSALRLSLAYLAIAIAWAFLSDHLLQNQVQDHDQLVFWMTAKRLFFFAATGLLLYLYLVRQFRRKAQAYDELHGSEQRLNRALEAVRDGLWDWDLV
TDRMFVSPGYAALIGLAPEELGDPIETWKKRLHPEEYATVLEAHRNHLQGLTDNLDHIYRLRHKDGDYRWIHSRGRVLRDALGKPLHYTGVARDITLQRL
KEDHLRQAAAVFDSTREGVLVTDAQAVIVHVNPSFERITGYRSEDVLGKTPAILRSGRQDQAFYQRLWLALREQDVWSGEIWNRRKSGEIYPQWLHIRAV
RNDQGQLTHYVGVFSDLSSIKRSENELDFLAHHDSLTGLPNRVLLRERIEQALENGKDRTVAGALLLIDLDHFKHINDSLGHTTGDMLLKEVSKRLQHQL
DERCLLSRLGGDEFAILVENDDPEAVARLSQRILDGFNAPFDIHCQPIYISASLGVSLYPEDASDVDHLMQHADAALFQAKDSGRNAYAFYTRVLTARAR
AHVQVESALRHALEHDELRVHYQPVHDLASGRIVGVESLVRWQHPERGLVPPGEFVPVAEECGLIAALDNWVLKRACRQMREWQQRGVELEFVAVNVSSR
LFNRGGLEERIANALEESGLEPRYLELEVTESAVMEDFEQSLNLLCRLRILGVNLAIDDFGTGYSSLMRLKRLPVHKLKIDQGFVAGLPGAVDDAAIARA
IVALAQSMGLRVVAEGIEHQDQALFLREHGCDFGQGYWYGRPQPAEALRFDLPPVALPED
>tr|A0A081B6H2|A0A081B6H2_9PROT PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=alpha proteobacterium MA2 GN=M2A_0139 PE=4 SV=1
-----------------------------------KRRGFLSAAARN---------------KAPGRRAAAARARAKQAEAQL--QFHENQINTAEENSA
FGSWFWDKNAWRLLGIEKRARAGLTDALAERAH-PDDQETLISAIRGQVDRGEAYDIEVRFLSEEGYRW-IRARGYALRDTGMRVHAVGGSIEDITERVE
MLEQLQENESLVSAAPFPLIITNLRKVIYT--------NAMANDLFGVTPDFFVDKA--DLAQLR--ADLLNQGYSTGREARLKKTSG--EEFWAFISCL
IEHNGQP-CAYVIMHDLTERKRLEDELRQRAQFDVLTGLYNRQTFADLMAEAVRETEATGEVFGLLLIDLDRFKNVNDTLGHEAGDQLLIQASTRLQDLS
PENCQIARLGGDEFAILYRGLDSPAIEELAGALISEISAPYEVIGNMVNVGCSIGIAIYPWHNGLSNELMRYADMALYKAKELGRGQYFVVDDKLTEEVH
ERGKLQQDMRQAIERGEFRLVYHPRMCARTRKPIAAEALLRWDHPERGPIPPDQFIPIAEETGFITVLSRWVVQTAVFQLRSWMAMGLQPLPVSLNLSAA
DLMLQDQAQEIGALLSELEVPPSLLQVEMTESSLLSD-RERVQQLAELAGMGVELLIDDFGTGYSSLAYLHQFQVHKLKIDRSFVQRLTHAPDA-LLTRQ
IVEIGKGLGLCVVAEGVETASQADLLTAMGCDELQGFYFNKPLDLAAY------------
>tr|E6TT13|E6TT13_BACCJ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Bacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM 
-----------------------------------RIEGIYG-VIRD---------------ISQ---LRIYEKNLSFIERSLNNAQYIANIGSWDYDPH
NDKLYWS-QMFRIFGLDEKTNTAPSMEQYLKYVHHDDRLRDIVAIQDAMEKKKSFNYESRIFRKDGMKRIVKIQGNPIIDNEGNVVKIIGNTHDITEQKE
ANQRLVDNEIIFNNLDE----IDIRKVIFCSNGF-EQLFGYCLDDLIDE-QKVIH--EEDIKGIPEKLITLSQGNQLKFECRVQHTSA--EVRWIEIKAI
IDDLGDFIRVDGIIRDITEKKKLDAKMHHIAHHDHLTNLPNRRSFDIKLHELIHHAKKTKSIFSVFYLDIDRFKHVNDMLGHNYGDDLLKEISYRLKQVL
Q-SHFIARTSGDEFAVLLHDVTEEEVIVFAHNIVNVMRQAFHISEVESYVTASIGIAFYPKDGENAVTLLKNADTALSFAKIDGKDNYKHYIPEMNEDSH
NIYFLEKDMRLALEKEEFYLEYQPKIDVKTKKVIGCEALIRWTHPKRGIVSPAQFIPIAEESDLICDIGNWVIKKVCKQLKKWHLEGINTVPVSINISAQ
HLLKTSLLDTIFTALKANHVSPSLLELEITETSLIQP-NQSVFTIRSLKKLGVKLSLDDFGVGYSSLTHIRKFPLDTLKIDKSFISKVPTEKDDAVIISS
IIEMAHGLGLTILAEGVETEEQLLFLEEKNCDHIQGFLFSKPISNDHF------------
>tr|A0A0A5G5F2|A0A0A5G5F2_9BACI Uncharacterized protein OS=Pontibacillus litoralis JSM 072002 GN=N784_05085 PE=4 SV=1
-----------------------------------EVQSVI-MTLHD---------------VTD---VHQLQAELQMEKTHLYYSQQIAKVGSWDYDVL
KDKM----YHYYLYGFNDKQAAEVESDWFFNRIHPDDQERMKQVVEHTFCTGEAQHVQYRIQRINDERTLTIESDIYAIKEQGQVVRLFGVVYDITEYDQ
MRKELNKQNNIYNSLN-----FDYNQVTFCSEGV-QHLYETPTEAFQNDKKCIYPDDRQRVLDMQ---APLHVGQEINHEYRIVTSTG--KVRWVKDQTK
VDENGELVSLMGIMLDITDRKLYEQKLEHSIRHDRLSKLGNGYYLE----ETFQKQVMQQQPMALFLIEVQRMKEMKESFGYALKDEVIQMIARRLEKGF
PAPFILARISDDELVALVKHGS-EAMVDRCERVHNEIKKEMTVQGYRLQISCNIGVSFYPRDGETCDEVLQSARKACNRGKESGQDRYFFYPNSDDAICF
KQIAIERDLRHAIKFNQFELHYQPKVDIQ-GTLQGAEALIRWNHPELGVIPPSEFIPIAEEGDFIIDIGNWVIAEVCRQLQDWSRRGFPLCPVSFNISPV
HLYKQHLICTIKGELRKHNVHGKWLEMELTETSFMNET--LVNLAKELKKLGMKMTIDDFGVGFTSLQYFQRIDRDKVKIDKSYIQGLNEGKGQNIIVSS
IIQLSHDLETKVVAEGVETIEQYEFLKAKQVDELQGFYFARPLPVSQF------------
>tr|A0A0D7QB88|A0A0D7QB88_9BRAD Diguanylate cyclase OS=Bradyrhizobium sp. LTSPM299 GN=UP10_16960 PE=4 SV=1
------------------------------------------MTARR---------------LSQGQAPMGVARRRWHEERSLRSAIRMARMGYWESQSA
AATDFWIPELAAFYEFETVDGLIPIVTASRRYV-PESRKILEAHYATCWAEGRPYAVQARLRRSDGSLLDCVVHGEPEFDALGQVRRVSGIVRDVTEETS
ALRRLAESEDFVSTASDPKSL-------------------------------------------------------------------------------
--------------------KEAERQLEQLAYSDPLTGLANRALFKRQLAALIEVCTLEGRGAAVLLIDLDRFKEVNDSLGHAAGDELLIRVAAALRQEL
GPRAFIARLGGDEFAVLAEGCGTAALTGLADRLIGRLSGPVDLTEGEAFVGATIGIARLPEHGVTAETAVRNADLALYMAKEAGRGRAQLFEPVYAQAVD
QRLDLARHLRHAVEADALQAHYQPQVDLRTGRVTGFEALLRWTHPERGPISPAEFIPIAESSGLIVDLGLWVLREACRQGRAWLDAGLPRRSVSVNVSPA
QIWSGDFETAVSAVLAETGFPAELLCLELTESLFVDHTEQRISTLTALSGLGVRLALDDFGSGYSSLGYLTRLPFHSLKVDRAFVDGISTAPEKRKLLGG
IIALSHGLGMKVVAEGAELPAELDLLGGLDCDVVQGFVFSPPIAADEA------------
>tr|A0A0D1LL07|A0A0D1LL07_BRAEL Bradyrhizobium elkanii strain UASWS1015 Contig180, whole genome shotgun sequence OS=Bradyrhizobium elkanii GN=QU41_18675 PE=4 S
------------------------------------------MAARR---------------LPQGQAPTRVARRRWNEERSLRCAIRMARMGYWESHSA
AATDVWIPEFAAFYEFETVDGFIPIATVRGRYL-PESQKVLETHYAACWADGQPYAVQTRLRKSDGSVLDCVVHGEPEFDARGQVRRVSGIVRDVTEETS
ALRRLAESEDFVSTASDPRSLYRLGRTTWASEL--YQLLGFDPDTFEPTRPRFLGADADRFRDVQ--KRVLRTRATEATDLRIVHADG--TPRDLAVICE
VA-HDKVIGIIGTVQDVTERKEAERQLEQLAYTDPLTGLANRALFTRQLATLIEGCAQQGRRGALLLIDLDRFKEVNDSLGHAAGDKLLVQVAAALRQEL
GPRAFIARLGGDEFAVLAEGYGMVALTELANRLIVKLSVPVDLTEGEACVGATIGIARLPEHGATAETAARNADLALYMAKEAGRGRAQLFEPVYAQAVD
QRLDLGRHLRHAVEAGTLEAHYQPQLDLRTGRVTGFEALLRWTHPERGPISPAEFIPIAESSGLIVDLGLWVLREACRQGRIWLDAGLPPRAVSVNVSPA
QIWNVDFETAVSAVLAETGFPAKLLCLELTENLFVDHTEQRISTLTALSDLGVRLALDDFGSGYSSLGYLTRLPFDCLKVDRAFVDGISTAPEKRKLLGG
IIALSHGLGMTVVAEGAELPAEVDVLGGLDCDQVQGFVFSPPVAADKA------------
>tr|Q2J2Z8|Q2J2Z8_RHOP2 Diguanylate cyclase/phosphodiesterase OS=Rhodopseudomonas palustris (strain HaA2) GN=RPB_0451 PE=4 SV=1
------------------------------------------MTVQR---------------ASL-RQPHAREARGWHQEWSLRRAMRMARIGYWESYSA
AATDFWIPEFASLFDFQTSKGSVPVDAMQQRRL-ADSRDVLHVHYAACWAEGRPFAVETKLVTSDGRQLDCVVHGEAEFDASGRVQRVFGAVRDVTPETS
AHRRLAESEDFVGTASDPDLIHRLGRTVWSPEL--YHLLGLDPAAFDPTKAYFLDDAAERMLEIQ--KRVVRTGTTEAADIRILHGDG--TPRDMAIICE
IR-DGKVVGLIGTAQDVTDRKEAERRLELLAYTDPLTGLANRALFKRKLAGLFEQPISGDGRNALLLIDLDRFKEVNDSLGHSTGDSLLIHVASVLRQEL
DPQAFIARIGGDEFAVLTNGQCADDPIALADRLIAKLSVPVELAEGEACIGATIGVAILPEHGATAEKASRNADLALYMAKEAGRGRAQLFEPIYAEAVD
QRLDLGRRLRQAVESGGLTTHYQPQIDLKTGRVSGFEALLRWSHPERGPISPSEFIPVAESTGLIVQLGHWVLRDACRQMRAWLDAGLPPRSMSVNVSPA
QIWNGDFEAVVAAVLAETGLPAELLCLELTENLFVDHTKQKVSTLAALSKLGIQLALDDFGSGYSSLGYLTRLPFNCLKIDRSFVDGIATVPEKRKLLGG
IIALSHGLGMSVVAEGAELAAEVDLLTGFDCDFVQGYVFSPPITADQA------------
>tr|Q6NCU9|Q6NCU9_RHOPA Complete genome; segment 2/16 OS=Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) GN=RPA0370 PE=4 SV=1
------------------------------------------MAVRG---------------VSL-RQPYPREPRGWHQEWSLRRAMRMARAAYWESYSA
TATDFWMAEFTSLYDADTPDDSVPLAPARDHDL-TDSHAILQAHYAACWTEGRPFAVETKLIKPDGRLLDCVVHGEPEFDANGQVQRVFGIVRDATPETS
ALRQLAVSEDFVSTASDPKSLHRLGRTVWSPEL--YQLLGLEPDAFEPTEPYFLDDDAARLLKIQ--KRVLRTSTTEATDIRILHTDG--TPRDLAIICE
IS-NGNVIGLIGTAQDVTDRKEAERRLEQLAYTDPLTGLANRALYKRKLADLFENPMAEHGQNALYLIDLDRFKEVNDSLGHSTGDSLLIHVAGVLRQEL
GPQAFIARIGGDEFAVLTNSPNTEATTALADRLIAKLSVPVELAEGEACIGATIGIAILPEHGATAEKASRNADLALYMAKEAGRGRAQLFEPMYAEAVD
QKLDLGRRLRHAVDSGGLNTHYQPQIDLKTGRVIGFEALLRWSHPERGPISPAEFIPIAETTGLIVDLGHWVLRDACKQMRGWLDAGLPARTISVNVSPA
QIWNGDFEKVVATVLADTGLPPELLCLELTENLFVDHTKQKVSTLAALSKLGIQLALDDFGSGYSSLGYLTRLPFNRLKIDRSFVDGIATVPEKRKLLGG
IIALSHGLGMSVVAEGAELQAEVDLLAAFDCDFVQGYAFSKPVAADQA------------
>tr|A0A0A1PQH5|A0A0A1PQH5_9BACT Cyclic di-GMP phosphodiesterase Gmr OS=bacterium YEK0313 GN=gmr_1 PE=4 SV=1
---------------------------------------------------------------------------------MLARALHLARMGYWKANGP
EATQLWIPELAELYQLSTPTGMVALETIRSSYL-GDGPDELARHFDACWRTGRSYTVRGTYLRPDGERREMIVHGEAERDADGRIAAVCGICRDITDETE
ALRRLAESEDFVSTASDAPGTYRLERVTWAHEC--FALLGLDRDRFDPTLAHFLGDGAGRIVALQ--KLVIRTKRTETIDVQARRADG--SIGDFALTCE
IDAEGRVLGLIGTLQDISERKEAERRLEALAYRDPLTGLANRALFKRELATVIDGCFRQGRAAALLLIDLDRFKEVNDSLGHAAGDELLAKVAGLLRAEL
GPKAFIARLGGDEFAVLPERRGEADIAAMADTIVARLTGPIDLTDGEAFIGATVGIAKLPEDGATVDEAMRNADLALYMAKEAGRGRSMVFAPAYAQAVE
QRLDLGRHLRRAIDEGTLHAHYQAQVELPARKVVGFEALLRWNHPERGPVSPAEFIPVAESSGLIVDLGLWVLREACRQAQSWIEEGLPTRGVAVNVSPA
QFWNMDFETAVSAVLAETGLPPHLLCLELTESLFVDHTEQRISTLTALSALGVRLALDDFGTGYSSLGYLTRLPFDRLKVDRSFVDGIATRPEKRKLLGG
IIALSRGLGMSVVAEGAEREAEVEVLTELGCDCVQGFVFARPVPPEAA------------
>tr|D6CJW3|D6CJW3_9BACT Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=uncultured bacterium GN=JG2_0110 PE=4 SV=
----------------------------------------------------------------------KFEEAVKKGEEQLKLFIEHAPAAIAMLDRN
LNYLVISRRWVEDFKLQSQNIIGKN--HFPEIPDRWKEV-LNCALEGLFSGKDSYSLSKRFIRKNGDMMHASTNIRCVRKSDGSVDYFVALVQDITDQVR
IEHERIRSEGLYNSSRDGILFLNMNGNIIDANPAFLEMIGYSREEVIGVNQFHITP---------PQWHSLERDIIMTGEKEFRRKDGSATPVTVRMWIS
K-ESGLTAGMWCTVHDISERKKTQEQLTHLSYYDVLTDLPNRMLFVDRLQQAIIAARYAGTAVAILFIGLDHFKRVNDTLGRTVGDHLLQEVAKRLKTCL
EEMQTVTRVAGDEFAVLLPNVEKDDAINICNQIFFAFKEPFKIDDHELFLSCCIGISLFPTDGKEPEILLRNANAAMDRAKGFGRNQYRLYSATMHEKTH
ERFILENSLRHAVDRNELCLVYQPQINLSTGDIMGVEALVRWKHPELGLITPTEFLPLAEETGLIVSIDDWVMREACLQAKKWLEMGFSPIRMAVNLTAR
QFQYTDVVDSVKKILRETSLSPYNLEIELTEHVIMQNVEETVQCLKQLSDMGVKISIDDFGTGYSSLSYLKRFPIHSLKIDEAFVRDITTDPDDAAIVKA
IISLAHHLKLEVVAENVETEPQRMFLKTEQCDRMQGFLYSRPVAPNVFTDLL--------
>tr|A0A0A1H4U9|A0A0A1H4U9_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Burkholderiales bacterium GJ-E10 GN=E1O_11140 PE=4 SV=1
----------------------------------------------------------------------EAEIALAYEREIFRNLADISSDYFWELDEQ
FRFRAISPSIAVRSQIDHQAYLGKA--R----FVGISED---QWKE---------------IEK-DDADWIGIYGNVAYR--PAPRQCSVTFQDITERKR
AESELR---TAFEVQ-EGILVTDVHSRILKVNAALTRITGYPVAECIGRTPRIFSSGRHDQRYYKDMWERLQETGRWEG----RRKNGETYPARLSITAV
RDVEGRVTNYVANIADITMSLAAAEEIRDLAFYDTLTRLPNRRLFLDRLHQAMASSARNGQKGALLLLDLDNFKTINDTLGHDMGDSLLQQVADRILRAL
REGDTVARLGGDEFVVLVVN-GDAFAKEVGNKLLVPLNRPFRLGG-R-HNTPSIGVTLFSGKE-TAEELMKQADIAMYHAKRAGKNTIRFFDRQMQDAVN
AHATRERDLRIAIDQQQFELHYQVQVDG--GKAIGAEALIRWHHPVEGLVGPTAFIPIAEESSLIVGIGDWVIDTACAQLAAWNLMPATRLVISVNVSSR
QLRHPDFAAKLEHSIASHGIDVRRLKLEITESMLLEETESTVAVMERLHALGLRLTLDDFGTGYSSLSYLKRLPIDRIKIDQSFIRDMASDPHDLAIIRT
IIAMAYNLQIGTIAEGVETDDQLRLLADSGCNTFQGYLFGKPMSIAEFERAL--------
>tr|H8FVI9|H8FVI9_PHAMO Putative diguanylate cyclase (GGDEF)/phosphodiesterase (EAL) with PAS sensor Putative two-component sensor histidine kinase OS=
----------------------------------------------------------------------RADAALRESEARFRALFDNAGAGVILTDAE
GRYLHCNPAFCAMVGYSESELHL-----FRDISHPDD---RDSV-------------------------------TPIRDEAGQLRHAVAVVEDVTETKR
LEDHMR---TVFENTGEGLFVTDERRRIIHVNPAFTVLTGYAPEDVLGKTPRILASGRHPPEFYDRMNESLVKTGRWQG----RRKTGEMFAEWLNIAEV
RDEHDRLTHYVAVFSDITSRKEDEERLSYQANHDPLTRLPNRTLFQERLSRALTRAHRNHSIVTLLFIDLDHFKQVNDTLGHLAGDCLLQQVAERLSSCV
RQGDTIARLAGDEFTVILEDVTERDSAIVAQKILSLMAEPFDLQGHEARISSSIGVALYPNDGDDPQTLIKLADAAMYQAKNQGRNACRFHSESVYAQAF
ERLGLENSLRLAVERNEFELYYQPVFAADTGRVMAVEALLRWHHPEIGLMTPDHFLPLAEETGLIFPIGRLVLESACRQTRLWLDQGIAPPRVCLNLSAR
QFHASTLADEIAAALAESNLPAAMLEFDLPESCLTEKGPKTDSLFTSLKTLGIGIAIDDFGSGHSSFSLLRQMRTDTLKISQDLVRDPAGSSGNTEVIQA
IVAVAHGLHIRVVAPGIETVEQLTSMIGYECDLLQGFLFSPPLPTEEMTAFL--------
>tr|S9SCJ7|S9SCJ7_PHAFV Uncharacterized protein OS=Phaeospirillum fulvum MGU-K5 GN=K678_09096 PE=4 SV=1
----------------------------------------------------------------------RADAALRESEARFRALFENAGAGVILTDAE
GHYLHSNPAFCAMVGYSEAELHL-----FRDISHPDD---RDAV-------------------------------TPIRDEAGHLHRAVAVVEDVTATKR
LEDHMR---TVFENTGEGLFVTDDRRRIIHVNPAFTVLTGYTPEDVLGKTPRILASGRHSPEFYDRMNESLANTGRWQG----RRKTGEMFAEWLNIAEV
RDERDQLTHYVAVFSDITSRKEDEERLSYQANHDPLTRLPNRTLFLERLSRALTRAHRNHSIVTLLFIDLDHFKQVNDTLGHLAGDCLLQHVADRLSSCV
RQGDTIARLAGDEFTVILEDITERDSAVVAQKILSLMAEPFDLQGHEARISASIGVALYPTDAEDTQTLIKLADAAMYQAKNQGRNACRFHSESVYAQAF
ERLGLENALRLAVERNQFEVYYQPVFAADTGQIAAVEALLRWHHPEIGMMLPDHFLPLAEETGLILPIGRLALDSVCRQARSWLDQGIAPPRVCLNLSPH
QFHSADLIADIQEALDRYALPASILELDLPESCLTEREPDTDAQFASLKALGVGIAIDDFGSGHSSFSLLRQVRTDTLKISQDLVRDPAGSSGNAEVIQA
IVAVAHGLHILVVAPGIETEAQLATMTGYECDMLQGFLFSPPLPAAEITTYL--------
>tr|M3AAZ6|M3AAZ6_9PROT Uncharacterized protein OS=Magnetospirillum sp. SO-1 GN=H261_12141 PE=4 SV=1
----------------------------------------------------------------------AADAALRTSESRFRALFDNAGTGVILSDAG
GSYIHCNPAFCTMVGYSDAELQT-----YRDITHPDD---VDAH-------------------------------TAMREADSDLRFTVAVVEDVTERKR
LEDHMR---TVFESTGEGLFVTDEKRRIIHVNPAFTELTGYPADEVIGRTPKFLASGRHTPEFYDVIFKALGETGKWQG----RRKTGEMFAEWLNISIV
RNERGELTNYVAVFSDITSRKQDEERLSYQANHDPLTRLPNRTLFQERLSRALTRAHRNQSIVALLFIDLDFFKQVNDTLGHLAGDILLQQVAERLSSCV
RQGDTVARLAGDEFTVILEDITERDGAVVAHKILSLMAEPFDLQGHEARISSSIGVALYPSDGGDAQTLIKLADAAMYRAKHQGRNACRFHSETVNAQAF
ERLALEGALRHAVERREFLLHYQPIFDSRSGKVVAVEALLRWRHPEFGMIMPNHFLPLAEETGLIVPVGRFVLEEACRQAKSWLDAGHAGLRVGINLSNR
QLRAPELIEDIAAALESSALPPGALELDVPESAILDKGQDVDAIFTQFKTLGVRMAIDAFGSGYSSFAFLRKLPSNTLKIDQSFVRDAASGAEESEIVTA
IVAVARGLHLSVVAPGIETQEQLDHLVKYDCDMVQGFLFAHPMPAEELTEFL--------
>tr|A4U4T7|A4U4T7_9PROT Two-component sensory box protein OS=Magnetospirillum gryphiswaldense GN=MGR_3962 PE=4 SV=1
----------------------------------------------------------------------HAASALKRSEGRFRALFANAGLGVVLADAH
GRMVEANPAFLSMVGYGEVELRG-----FRDITHPDD---IGLN-------------------------------TVMRE-DGQQPFTVTVVEDITERKR
LEDNMR---TVFENSGDGLFVTDAENRIIHVNPAFTRITGFTADEVLGRNPRLLASGRHDHDFFIQLWTVLLRDGKWQG----RRKDGEMFAGWQNIAVV
RDTDGKVQNFVAVISDITTRKQVEERLSYAANHDPLTRLPNRTLFQERLTRAIARASRNHNLVALLFIDLDRFKQVNDTMGHLAGDMLLQQVAERLSSCI
RQGDTVARLSGDEFTIILEDVQDRDAAVVGHKVLRLLQEPVALTGGEAHISSSIGVSLYPTDAGDPQTLLKLADAAMYRAKHLGRNSCQFHSEAVNAEAF
ERLALENALRGAVDQGQFLLHYQPIFDVKSGRAVAVEALLRWRHPEVGVVAPNQFLALAEETGMIVPIGRWVFDQACRQAKLWRDAGHVDLRLHINLSPR
QLRQPDLIEMVAAALEVSQLPPQALVLEVMETCVIDKAFDPSALFARFAALGVGLAIDEFGSGYSSFAFLRRLPVTILKVAQSFVRNLSSSEDESEIVTA
IVALARGLHMTVVAPGIENKAQLDFLTGFGCDKVQGFLLSKPLPGTEMTEFL--------
>tr|B0TF94|B0TF94_HELMI Predicted signal transduction domain protein OS=Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) GN=HM1_1853 PE=4 SV=1
----------------------------------------------------------------------------KARETQLSAVASALGEGLIVLDAE
GRLTFMNPEAERLLGWSLPELL------IHSIIHNRRPE-GDPIAEA-------------------TPL-----------ITGAVTA----FHDISDRKK
VEERLLLAA--IETTTEGIMITDAGGVIESVNPAFCRSTGYSESEAIGNSPRILKSGRHDGEFYRKMWKALLETGQWQG----RRKSGELYAAWLTISAI
KDSHGRTTQYAAIFSDITEDKRNQERIKHQAYHDALTDLPNRLLFIDRLTQAIAQATRNCYMLAVLFLDLDRFKQINDTYGHALGDLLLQGVAGRLRRAV
RDSDTVARLGGDEFTILLPQIGSEDAAKVAQKILASLRQPWSFEGIPSCITTSIGIAVCPTDGEEAETLMHNADAAMYRAKAQGRNHYQLYTPELNAWAF
ERLAMETRLRRALDQGEFVLYYQPKVEAATGNWCAVEALIRWQHPDLGLVSPTEFLRLAEDTGLIVPIGEWCLEEACVRNKAWQDAGLPPVRMAVNLSAR
QFQHPNLLAAVEKALQKSGLPPAWLELEISEEVILRFADLAPIVLGDLKSLGLSLTMDQYGKRDSRITLLQKLPIDRVKIAASQVIDLSACHDARKSVKA
LIALARSLDLHVAADGVGTREQCDFLTAAGCDEIQGHLFSDPLSAEEMGRKM--------
>tr|A1K5Q6|A1K5Q6_AZOSB Uncharacterized protein OS=Azoarcus sp. (strain BH72) GN=azo1544 PE=4 SV=1
-----------------------------------------------------------------------------MDQGFLQNVLDAIPAPVFFKDAA
GRYLGCNTAFLDFLGYTADRILGKSV---FELSPPDL---AARYHAQVWQQGMRQM-LEIVEDGQGRRLVFEATRIPLFD-VGQRKGIVVVGRDITERRA
AEERLR---TVFDNTVEGISITDRDGIIQSVNPAFSRITGYAEAEVIGCHTRILQSGRHGADYYRAMWRTLARTGQWQG----RRKTGEVYPQWLTIGTV
RDDEGEVSNYVAVFSDISQIKDAQSQLERLAHYDPLTGLPNRALLGDRLAHAISRARRAGTSVAVLFLDLDGFKNVNDSLGHPAGDRLLQIIAERLCGAL
RSEGSVSRFGGDEFAVVLEDVVREAVSEVAEHLIAEIARPLDLDGHGAHVSASIGIALFPRDGDDATTLIKAADTAMYRSKALGRNTFSFHHEDMAQAAH
RRLSLEHGLRQALEQGRFELWYQPQIDLRTGVLAGAEALLRWRDPERGLVSPAEFVPLAEETGLILPIGLWVLEEACRAGRAWLDVGLAPGRIAVNVAAP
QIERGGFDQAVARVLSASGLPPAALEVEITEGSLLRSAENARLAVAALRALGVGVAIDDFGTGYSSLAYLKNLAVQTLKIDREFVRDLPHDAGNLAITRA
IIAMCRSLGFGVVAEGVEEPAQAAFLVSEGCTLAQGYLFAKPMPGAEFAEWL--------
>tr|B1Y3M1|B1Y3M1_LEPCP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) GN=L
----------------------------------------------------------------------------------------------------
-------MSRRVRS----QPGASRQ--G----AAAAAATPATEAER---------------LVQ---------GAG--MAANHDAPLLRIALTDISERKH
AESELR---TAFEAQ-EGMMITDAHGVIERVNKAFTQMTGYSAAEAIGQTARLLHSGRHDPAFYAAMWDSLQRTGTWQG----RRKCGEVYAEWLTITAV
QDEHRTVTRYVGTMLDISQRKAREEEIAQLAFYDPLTGLPNRRLLKDRLNQAMAISARSQREGALLFIDLDHFKDINDTRGHDKGDLLLQNVAQRLSGCV
REGDTVARIGGDEFVVMLGADSTTDARSVAEKILAALNLPYLMSEFV-HCSASLGVALFNDHHDTVDELLKRADQAMYQAKAGGRNTLRFFDTAVQQTMM
LRAALEAELRLAVQRDELVLCYQPVIDH--NRLLGAEALVRWKHPRRGLVSPAEFIPIAEDRGLIQAIGRWVLETACTQLATWAADPATALVLSVNVSAR
ELHEPQFVERVIEILACTGARPARLKIELTENAVLDHVDDSIAKMKRLKAHGIRLALDDFGTGHGSLSLLKRLPLDELKIDRTFVQDLLTDTHDAAIART
IAALGLNLGISVVAEGVETPAQRDLLIACGCRIFQGDLFGPPAALEALARMA--------
>tr|A1WXR7|A1WXR7_HALHL Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halorhodospira halophila (strain DSM 244 / SL1) GN=Hhal_1715 PE
----------------------------------------------------------------------------------------------------
-------MGEDERRTLSPEALREAA--R----RR----VTVSDWSR---------------AVE-LTLAWAE------EPADRSPCRFRCALMDITERRR
SEEQLR---RVFEDAGDAIVVTDPDGHVQTINNAFTRITGYTEGEALGNTVALLDSGRHSEAFHKEKQESLDRSGYWQG----RRKGGELYPEWLTINRI
DDATGQPQHFVAVFSDITQLKDAHSRSEYLANHDPLTGLPNRSLFQDRLQQAIAQTQRHEGQVGLMFLDLDHFKTINDTLGHEVGDELLVQVAERLGELV
RDVDTVARIGGDEFTVVLTDC----VGSIAQRLVEGLGGTFVVDR-E-QATPSAGLALYPRDGEDVHTLCKAADMAMYRAKEDGRNRLRLCESGLHQRLL
KDTALEEALRRALTQGELRLVYQPQFDASDGRVVGAEALLRWHDPASGPISPGRFIPIAERSDLILELDRRVEELLCEQLNTWSAGHAP-APISFNVSAK
SFRQGHWTKRLFRILSRYGVAAEQLQVEFAEGTLSERAGVVPEEIRRLHEGGIALAIDDFGTGFTSLVNLKQLPLAELKIDQSFVAGLGQDEDAEAIVRA
SLAVAEAMGLRTVAEGVETQRQLTWLQEQGCQRIQGSLLSAPLEAEDFEALI--------
>tr|A0A0C1Y8K5|A0A0C1Y8K5_9BURK Diguanylate cyclase OS=Herbaspirillum sp. TSA66 GN=TSA66_24460 PE=4 SV=1
----------------------------------------------------------------------------RESEHKFRTFVEQSLVGLYVVQ-D
GKIAYANTKTADLLAYDSPEQLI-----VADLTHPDDT----RLLQ--------------------SLC-----------RPAIMGV----ALDVSQQVD
FEHQSRLAN--FESASEGIVMTDAECRIEAVNPAFTRITGYTAEEARGKLSRMMTGEGAKAKVNRDMLSHLARDGHWQG----RRKSGEWYPAWLSISTV
RDADRNITNYVGVFTDNTARKEAESRLQYLASHDSLTGMLNRSGLMVRFAAEIERAAVASRQLALLFIDLDRFKTVNDTLGHVAGDQLLVAASERMRHEL
RHSNIAARLGGDEFTVLLEDPPSGAAARLAERLITSMSQPFVIDGQEMFVTASIGIACYPADGTDANTLLKNADVAMYRAKERGKNNFQFFTSDMNAETF
EQMLLENSLRRALERGEFELHYQPQVATATGKLAGVEALIRWRHPELGLVLPATFITLAEQNGLIVPIGAWVMREACRQGRAWLDAGWDFGHIAVNLSAR
QFSSGDLLDTIRGALDQSGLPPRMLEFEITESTIMHNPQESITLLGRIRDMGVALSIDDFGTGYSSLASLKQYPLDSLKIDRSFVTGIPQDADDVAITEA
IIAIAHKMGLQVVAEGVENSEQAEFLRRAGCDIAQGFLLGRPMPASEIARQY--------
>tr|J2UN02|J2UN02_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Herbaspirillum sp. CF444 GN=PMI16_00979 PE=4 SV=1
----------------------------------------------------------------------------ADLARSFRYFADQSLVGVYMLRSD
GTVLHANDKMANMLGYECAADLT-----IGNLTAPEDL----ALLE--------------------SVC-----------GTALVEM----ALDVNQKVQ
SEWQSRLAD--FESTSEGILITDAEFRILAVNPAFTRITGYHPEEAMDKRSRMMTGPSAQAEINRGMLQRLASDGHWQG----RRKDGSWYPAWLSISAI
RDNQGGITNYVGVFTDNTIRKEAENKLAFLADHDSLTGLLNRNSLMRIFAQQIEAAQISGDTLALFFIDLDRFKTVNDTLGHHAGDQLLVAAAERLREQL
RPDDVLARFGGDEFVVILGGSPPEMIAAIAQRLINSILRPFTVNGHEMFISASIGSAAYPEHGEDAIAILKNADIAMYHAKERGKNAFQLFNKEMSNHAL
EQMLLENSLRHAIERKEFELYYQPQFSALDGAICGAEALIRWRHPTRGLVAPGMFITLAEQTGLIVPLGAWVLREACRQGKAWLDRGYQFGRIAVNLSPR
QFSSDDLLSTIDNALAQSGLPSAMLELEITEGAIMQNPQEAVVLLKRMRELGVTISVDDFGTGYSSLASLKQYPLDTLKIDRSFVKGIPGDADDIAITEA
IIAIAHKLHLQVVAEGVESQEQHDFLRAAGCDIVQGYLHSQPLSAGEIEARW--------
>tr|G2E3C3|G2E3C3_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_2786 PE=4 SV=1
----------------------------------------------------------------------------LSRLERFRALLDCAGEMLLVALPS
GQVIDANAAAAELLDLPLDGVI------LDVLGFSH----A-EVILA-------------------RAA-----------VLYGVLL----GRDATRRVA
AESRLRLAA--FADSAEGILVGDRRGRVVEINHAFEAITGYARDEVMGWPMHAFVSSRHDPGFFRSARQALKADNSWQG----QRKNREIYPLWLSLSLI
RDHRGRVQNFVAMFSDISERKENEARIQHMAHHDFLTGLPNRFLLIDRLTQLLATARRDGRRFAVLFIDLDRFKTINDSLGHRVGDRLLCAIGERLRGRL
RTSDTVARQGGDEFIVLLSYIEGTEVVRVCNMLLSALSEPCLFEGHELSVTPSIGVAIGPDDGTDSDTLLKHADLAMYQVKRRGRNDFEFFRNEMRVHVT
TLLQLERDLRHAVERDELEVFYQPQMDLRRGGLAAVEALLRWHHPERGLVLPGDFIPLAEESRLIVPIGEWVLRTACRQLAAWRAGQWPELRLAVNLSPV
QFQQAELIEVVRSALDDSGLDPEVLELEVTEGLLMDNRDLTLQALADLKAMGIRLSIDDFGTGYSSLVYLKRFPVGQLKIDRSFVRDLLEDRGDAAICET
IIALAGHLDLEVVAEGVEQVEQLDWLREAGCDRAQGYLLGRPMSVDALERRL--------
>tr|G4SZ26|G4SZ26_META2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 /
---------------------------------------------------------------------------------MHSANNDTKPA--------
--------------------------------KNPADIDDRHEAEA---------------LDRHKKPIYIELSGRLI-AVDFNHDCLLVNIITIGERKK
MEEQLK---KVFEHSQESIMITAPDTTILKINFAFTAVTGYKPAEVIGRTPKILSSGRQSPEFYRDMWQKINKEGCWQG----RRKNGDLYAEWLSICRI
NDKFGRVSHYIGIFSDITLRKLNEKQIEQLAYFDPLTELPNRALLNDRLKQGIVQAVRHKLWLSVFFLDLDRFKILNDTLGHFAGDLLLQNVAKRLKSCV
RESDTVARFGGDEFVILLTDF-VEQSAEIAKKILDVLSQPFDLSNQF-ITSTSIGFTLFPKDGSSVDELIKNADAAMYHAKASGRNNYQYFSDNMRSEAL
TRSTLENDLHHALPNHEFIVYYQPLIDLQTNQIIGFEALLRWNHPRKGLISPDDFIPIAEETGMIVAIGEWVLKSACKQFKIWRDQDQPQKKICVNLSAR
QFLQNDLVHSIRQCLDSTGLDARFLEIEITETVMMQHMSAVIRILQQLMQMGITVSLDDFGTGYSSLTYLKKFPINSIKIDRSFVRDILNDPDDKVIVHS
IISIARHMRLDIIAEGIENNEQATYLMQAGCRFGQGFLYSKPLPADGLIDLF--------
>tr|Q478F7|Q478F7_DECAR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (strain RCB) GN=Daro_4048 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------MKSSQ--G----CCP-------DDAR---------------KIR-DEADWTYVRKD--LRAKGGVQGYLGIASDISERRR
MEHDLR---IAFESQ-AAIMVTDVNQRILRVNQAFTKLTGYSAEEAIGQTPGMLKSGRQDADFYAAMWCSLGQCGHWQG----RRKNGEIFPEWLTISGV
RDGRGKVTHYVSTFSDISNLKVAESEIHHLAFYDPLTAMPNRRLLLNRLDQACVSAKRSGQFGALLIIDIDHFKTLNDTLGHDVGDHLLVEVARRLSACI
REGDTAARQGGDEFVVMLEE-GSQEAEIVAEKIRLELARPYLLNDTE-FRSASIGISLFFGQEKTIDILLKQADIALYKAKDAGRNAIRFFDTAMQTTLD
ERAELEAGLRRALVRDEFVLYVQPQVDA--RRLIGAEALLRWQPPGRAMVAPNDFIPLAEETGLIVPIGIWVLDQACAELRRWADDPRSALFLSVNVSAR
QFRQADFVAQVADALARHGANPRLLKLELTESLLLDNVEEVIEKMQALRTIGVRFSLDDFGTGYASLSYLKRFPFEQLKVDRSFIRDININPDDAAIVRA
IIAMGNTLRLSVVAEGVEDDLQHAYLVKHECSLFQGYLFGRPMSFDDFRASL--------
>tr|G3IRV4|G3IRV4_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_2660 PE=4 SV=
----------------------------------------------------------------------RVSEVLRLNEDRLYQATLVSGTGVFEQTYG
NDSIYCSPELRTHFGWDADELVT-----FTASIYPDDRK---RVIEA---------------FETDGDV-------S---AVRTVGA----VRDITKKKL
AEQEQRI-F--AFQTQEGIIVTDANQIIVRVNQAFTIITGYSTEEAIGNKPSMLKSGRHDNFFYHAMHKTLHSEGYWQG----RHKDGRIYPKWLTITAV
KDSDDKTTHYVGNFSDITERKRAEEHIHYLANFDWLTGLPNRTQLNDHLKYALSLAKRSNGHLALMFLDLDHFKDINDSLGHSIGDALLIKLAKRLRAAL
REEDTVTRLGGDEFILLLPGVDAGAAHV-AQKLLDTIAESYRIEHYDLILTASIGIALYPEDGEDLEALSKSADTAMYRAKQEGRQCYRFFTQEMQARSA
RNLQLVNALRHALDRSQLQVHYQPQISMRDGAIIGAEALLRWQHPELGMVSPAEFIPVAEGSGLILPIGEWVLRCAVQQAKAWVNEGFGPLIMAVNLSAV
QFRHPDLPELVTRILDEEGLPPEYLELELTEGVAMHNPQSAIAVMNNLQERGVRMSIDDFGTGYSSLSYLKEFKVYKLKIDQSFVRDISTDPEDKVIVSA
IINLAKSLGLKTIAEGVETEGQQAFLREQGCDEMQGYLFSKPVSAEQFDALL--------
>tr|G0A7C6|G0A7C6_METMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylomonas methanica (strain MC09) GN=Metme_0982 PE=4
----------------------------------------------------------------------ATLAALRVSEQQNRLILDNAGDGIIILNDQ
GLIESFNHTAQEMFGYPANTVIG-------KSLF-----------AD---------------YADKSSF-------PV--GRVYTLI----VRDITLRKH
FEQKLSQTH--FENTSEGIVITDTDNRIVAVNKALCAMTGYTQAELIGQFPSKWKSGLHDEVFFSKLWRALLDEGQWQG----RHKSGEVIPMLENINVI
RDSKGAISSYVAIMTDITGIKQYEERLSHLAHHDPLTGLANRILLEKRVSFAMRQAKLQKHLLAVLFIDLDRFKNINDSFGHSVGDLLLKEVGSRIASSV
RETDTVSRLGGDEFVVILGELDGEFAHVVAHKLLRILGHAIVIEGREFIVTPSIGIAMYPDDALTIEDLFKHADTAMYHAKNQGRNNCQFYSAGLSWKVY
ENLMLESALHNAEERGELSVHFQPQFDLKSGKLMGAEALVRWLHPELGLISPSQFIALAEESGQIIKLGEWVVRNACVQIKQWLDQGFNLGRVSVNVSAL
QIQRGNFAELVGRVLRETRLAPGFLELEVTESFIIEAE-QSLAMLDTLREMGVELAIDDFGTSYSSLKYLKLLPIQRLKIDQSFVRDIPKDPNSNAIARA
VIAMAKSLQLETVAEGIENAQQRDFFMAEGCQCGQGYYLGKPVSAAAFVELY--------
>tr|A0A028V2Z4|A0A028V2Z4_PSEPS Diguanylate cyclase OS=Pseudomonas pseudoalcaligenes AD6 GN=AU05_22120 PE=4 SV=1
----------------------------------------------------------------------RARLALAGNEERLRLALDATRDGLWDWDVS
RRKVFFSEGYARLLGLTPQAL-GDTRDW--SRLHPDDMERLH---AL---------NIYRLHHADGSYRWIHSRGRLL--ENGQPQRFIGIASDITQQRA
IDDSLR---AVFDATQEGVLVTDAEQNIVHVNPAFSRITGYSSEEILGQHP-LLKSGRHDTAFYQSLWHALQNRGAWSG----RRKSGEIYPQWQCIRVI
HDEQGRVSHYVAVFSDITALKRSQRELDYLAHHDPLSNLPNRLLFTERVAHALERSKIEELRGAVLLIDLDHFKHINESLGHNVGDLLLKGVGERLLQNL
PNGCTLARLGGDEFGLLSENCAEAQAAELAQCLLRSLETPFRLNDHELYIGASIGISLFPEDADSVEQVLRNADSALFKAKSSGREGYAFYEQELTDYAR
QRVELASSLRHALDNDELRVYYQPLHDLRDGRQVGMEALVRWQHPQRGLVAPGEFIPIAEDNGMIGAIDAWVLEQACQQMMRWNGEGNT-SFVAVNISSR
LFSRGELAQKVASVLTQTGLPPEQLELEVTESAIMEDPDAAQKLLISLRALGVRLAIDDFGTGYSSLARLKRLPVDKLKLDQSFVRGLPDDAEDAAIARA
VIALGKSLGLKVLAEGIEQRAQADFLRELGCNYGQGYHFGRPQPVASKSVDP--------
>tr|A4Y0E0|A4Y0E0_PSEMY Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudomonas mendocina (strain ymp) GN=Pmen_4309 PE=4 SV=1
----------------------------------------------------------------------RARLQLTSNEERLRLALDATRDGLWDWDFA
AQRVFFSPSYAALLGLTPQAL-GDTRAW--ERLHPEDRERLQ---AL---------NVYRLRHADGTYRWFHSRGRLL--EGGRPQRFIGIASDITQQRA
NDESLR---AVFDATQEGVLVTDPEQRIVHVNPAFSRITGYSAEEVLGQHP-LLKSGRHDAAFYQSLWQALHNRDAWSG----RRKSGEIYPQWQCIRVI
HDEHGRISHYVAVFSDITALKRSQRELDYLAHHDPLSNLPNRLLFTERIAHALERSKSEQLRGAVLLIDLDHFKHINESLGHNVGDLLLKSVGERLQQDL
PGGCTLARLGGDEFGLLSETCADPQAAELAQNLLRCLEAPFRLDEHELYIGASIGISLFPDDADSVEQVLRNADSALFKAKSSGREGYAFYVQELTDYAR
QRVELASSLRHALDNHELRVFYQPLHDLENGNPVGMEALVRWQHPQRGLIPPAEFIPIAEDNGMIGPIDAWVLEQACGQMMRWNAEGSA-RFVAVNVSSR
LFSRGELDLKVAQVLAETGLSPQQLELEVTESAIMEDPDAALSLLTRLRALGVRLAIDDFGTGYSSLARLKRLPVDKLKLDQSFVRGLPDDIEDAAIARA
VIALGHSLGLNVLAEGIESPAQVDFLRALGCDYGQGYHFGRPAPVTANHGGT--------
>tr|U2B6X2|U2B6X2_9PSED Diguanylate cyclase OS=Pseudomonas sp. EGD-AK9 GN=N878_17735 PE=4 SV=1
----------------------------------------------------------------------RARLQLADNEERLRLALDATRDGLWDWDYA
SQRVFFSDGYAALLGLTPQAL-GDTRAW--ARLHPEDRERLQ---AL---------NIYRMRHADGSYRWLHSRGRLL--EAGQPQRFIGVASDITQRRA
DEDSLR---AVFDATQEGVLVTDPEQRIVHVNPAFSRITGYAAEEILGQQP-LLKSGRHDAAFYHSLWHALQSRGAWSG----RRKSGEIYPQWQCIRVI
HDEQGRISHYVAVFSDITALKRSQRELDYLAHHDPLSNLPNRLLFTERVAHALERSAGEQLCGAVLLIDLDHFKHINESLGHNVGDLLLKEVGERLLAAV
PAGSTLARLGGDEFGLLCEHCAETQAAELAQRLLRCLDAPFRLHGHELYIGASIGISLFPDDAASVEQVLRNADSALFKAKSSGREGYAFYVQELTDYAR
QRVELASSLRHALDNQELRVYYQPLHDLQDGSAVGMEALVRWQHPQRGLVSPAEFIPIAEDNGLIGAIDAWVLEQACRQMVRWHAAGSA-RFVAVNVSSR
LFGRGELEQRVAQVLADTGLAPAQLELEVTESAIMEDPDAALLLLTRLRGLGVRLAIDDFGTGYSSLARLKRLPVDKLKLDQSFVRGLPDDAEDAAIARA
VIALGHSLGIKVLAEGIEQAAQADFLRELGCHYGQGYHFGRPQPVPSQPIGV--------
>tr|A0A0A1YLE4|A0A0A1YLE4_9PSED Diguanylate cyclase OS=Pseudomonas taeanensis MS-3 GN=TMS3_0101965 PE=4 SV=1
----------------------------------------------------------------------RMRNALTASEERLSLALDAAKDGLWDWNLQ
TLKVFFSPGYTRLLGLEPGDL-GDSRSW--HHLHPDDHAHQQSIVQL---------NTYRLRHRDGSYRWIQARGRLL--AQGRPQRLIGTASDITQRRA
DEDSRR---AVFDATQEGVLVTDAAQRIVHINPAFSRITGYSEAEILGQQP-LLKSGRHDPAFYAALWQTLQSLGAWSG----RRKNGEIYPQWQCIRAI
HDEQGGVSHYVAVFSDISALKRSQHELDYLAHHDPLSDLPNRLLFTERVAHALQRAQREQHGGAVLLIDLDHFKHINESLGHNVGDLLLKAVGERLSAQL
TTGMTLARLGGDEFGVLCEDCLHQLAAEFAQQLLDTLNTPFRLDGHELFIAASIGISLFPGDAQSVEQVLRNVDSALFKAKSNGREGFAFYAQELTEYAR
QRVELVGALRHALEGNELRVHYQPLLCLQSQRLIGVEALVRWQHPQRGLVPPGEFIPIAEESGLIGAIDAWVMAHACRQMVAWQAAGSA-QFVAVNVSSR
LFSHGKLDGQVAQVLAESGLDPACLELEVTESAVMQDPDAAQGLLERLRDLGIRLSIDDFGTGYSSLARLKRLPVHKLKLDQSFVRGLPHDHDDATITRA
VIALGHNLGLKVLAEGIEQPQQMEFLRQLGCDQGQGYYLGRPQPAEQLPTAF--------
>tr|A0A0D0JH39|A0A0D0JH39_9PSED Strain MEJ086 contig_6, whole genome shotgun sequence OS=Pseudomonas fulva GN=RU08_03510 PE=4 SV=1
----------------------------------------------------------------------RIGTALHASEERLSLALSATEDGLWDWDLR
NQSVFYSAGYHALLGMKDGEL-SADRQW--QLLHPDDRPHQRVLADI---------NTYRLRHRDGSYRWVLSHGRLQ--AQGRPERFIGTVRDITQRRA
DAESLR---AVFEATQEGVLVTDARQNIVHINPAFSRITGYSEAEILGKHP-LLKSGRHDAAFYQHLWHTLQTQGTWSG----RRKNGEIYPQWQCIRAI
HDDNGLLGHYVAVFSDITVLKHSQHELDHLAHHDPLSNLPNRLLFTERVEHALERAQSEADRGAVLVVDLDHFKHINESLGHNVGDLLLKATGERLASQL
GKGTTLARLGGDEFGLLSEDCTQEQAAHLAQRLIDCLNEPFILDGQELFISASVGICLYPDDAQTVEQVLRNVDSALFKAKSSGREGFAFYDQEQTEYAR
HRVELVAGMRHALDNEELRVHYQPLRCLTDGRMIGVEALVRWQHPQRGLVPPGEFIPIAEDSGMISAIDAWVLDHACRQMVSWRAAGST-QFVAVNISSR
LFSRGELDQRVAQVLADTGLPAQCLELEVTESAVMDDPDQAQALLERLRSLGVRLAIDDFGTGYSSLARLKRLPVQKLKLDQSFVAGLPHDKDDRAITRA
VIALAHSMEMKVLAEGVERGEQQDYLRQLGCDYAQGYFIGRPVPADVLEQT---------
>tr|F6AG02|F6AG02_PSEF1 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudomonas fulva (strain 12-X) GN=Psefu_0356 PE=4 SV=1
----------------------------------------------------------------------KIGTALRASEERLSLALSATEDGLWDWDLI
RQRVYYSPAYHALLGMNDGEL-SADRHW--QLLHPDDRAVQRVLDQL---------NSYRLRHRDGSYRWVLSRGRLQ--AQGRPARFIGTVKDITQRRA
DADSLR---AVFESTQEGVLVTDAQQNIVHINPAFSRITGYSEAEILGKHP-LLKSGRHDAAFYQNLWHTLQTQGTWSG----RRKNGEIYPQWQCIRAI
RGDHGLLSHYVAVFSDITVLKHSQHELDHLVHHDPLSGLPNRLLFSERVEHALQRAQRDEERGAVLVVDLDHFKHINESLGHNLGDLLLKATGERLASQL
GNGSTLARLGGDEFAVLSEDCTQEQAAHLAQTLIDCLDAPFLLDGQELFISASVGICLYPDDANSVDQVLRNVDSALFKAKSIGRGGFAFYDQEQTEYAR
QRVELIAGMRHAIENGELRVHYQPLHCLSSNRLIGVEALVRWQHPQRGLVPPGEFIPIAEDSGMIAAIDAWVLEHACRQMVAWRSEGQS-QFVAVNVSSR
LFSRGELDQRVAQVLASTGLPAGCLELEVTESAVMDDPDQAQALLERLRSLGVRLAIDDFGTGYSSLARLKRLPVHKLKLDQSFVAGLPDDKDDLAITRA
VIALAHSMEMKVLAEGVERAEQLERLRQLGCDYVQGYFIGRPVAAQDLQLA---------
>tr|U2YZR1|U2YZR1_PSEAC Uncharacterized protein OS=Pseudomonas alcaligenes NBRC 14159 GN=PA6_003_01400 PE=4 SV=1
----------------------------------------------------------------------LARAALKGSEERLALALDSAQEGMWDWDMK
SNRVFYSRRYCEMLGYSPEDF-GTDRAW--SRLHPEDRHLEERLRAL---------GIFRLRHRNGDYRWLYARGQLL--EDGEPSRFIGTSSDITQRRA
DEESLR---VVFDSTLEGVLVTDRELKIVHVNPAFSRITGYSSDEVLGKAP-MFKSGHHDPDFYRSLWHALEQRGSWSG----RRKGGDVFPIWQCIRSI
HDENGNLSHYVAVFSDISAIKHSQQELDYLAHHDPLTSLPNRLLFGERIDQALQRARQDGRRGALLLVDLDHFKIVNESLGHNTGDQLLKLIGERLHNAL
GQGVTLARLGGDEFGLLSGDCAQEHASLLAQRLLDCLEQPFSIGDETLFVGASIGISLFPDDGDSVEKLLRNADSALFRAKSSGRQTFSFYSQEMTAQAR
QRIKLEAELRVALEQEQLRVHYQPIHRLDDGAMLGVEALVRWQHPERGLVAPGEFIPVAEDSGLIGAIDAWVLEQACAQMVRWLAEGRA-EFVAVNVSSR
LFGRGELDRRVERVLRQTGLAATHLELEVTESAVMDNPERAQELLGHLQGLGVRLAIDDFGTGYSSLARLKRLPVHKLKLDQSFVRGLPQDSEDAAIARA
VVSLGQSLGLRVLAEGIETAEQAAYLREAGCNLGQGYWFGRPQPAEQLLAVS--------
>tr|A0A081YDX7|A0A081YDX7_9PSED Diguanylate cyclase OS=Pseudomonas sp. AAC GN=FG99_07925 PE=4 SV=1
----------------------------------------------------------------------RTFAARERSERRFERALDALDDGLWEWDIE
RHRVFYSPGYARLLGLSEEAL-GDSFTW--QRLHPDDRDSLAQHRDL---------CTYRLRHADGNYRWVHARARLS--HDGEPLRMTGVSRDVTEQRK
ANDHLR---AVFEATQEGLLVTDDKGMILHVNPSFQRITGYSADEVVGRNP-MLKSGRQDDAFYQRMWQALNAEGLWCG----RRKSGEVYPQWQHICAV
HDEQGRLTHYVAVFSDLSSIKRSQHELDFLAHHDPLTGLPNRLLLRERIEQALARAEREQGSGALLLLDLDHFKHVNDSLGHSAGDQLVKTVAERLRGCL
DEHASLARLGGDEFAVVLE-SQQHHASSLAQRLLEAMHAPFEVQGQPIYISASMGVSLFPDDARDVDHLLRHADAALFQAKASGRNLYAFYTPELTARAR
SHVQVEAALRQALEHDELRVYYQPVHDLASGQVVGVESLVRWQHPQRGLVPPCEFIPVAEECGLIAAIDAWVLDQACRQMRQWLDDGVA-DFVAVNLSSR
LFGRDGLEQRVARALQESGLQPRHLELEVTESAIMQNIDQSVALLQRLRALGVQLAIDDFGTGYSSLMRLKRMPVQKLKIDQGFVAGLPGDAEDAAIARA
IIALARSMGLSVVAEGIERPDQAAFLLDHACDFGQGYWYGRPQPADELPWAR--------
>tr|A0A024HQS4|A0A024HQS4_PSESB Uncharacterized protein OS=Pseudomonas knackmussii B13 GN=PKB_5603 PE=4 SV=1
----------------------------------------------------------------------RAYAALMASEQRLNRALNAVEDGLWEWDLR
SDRVFYSSGFARLLGLPAEEL-GDSKFW--DRLHPDDREALQAHREH---------CTYRLRHADGGHRWIHSRGRAI--THGDPVLMTGVSRDVTRQRS
LDDHLR---AVFEATQEGLLVTDEHGVILHINPSFQRITGYTADEVLGRNP-MLKSGLQDNDFYQRMWQTLGRDGVWCG----RRKNGEVYPQWQHICAV
HDDRGQLTRYVAVFSDLSSIKRSQRELDFLAHHDPLTGLPNRLLLRERIDQAIVRAGREMGSGALLLLDLDHFKHINDSLGHSAGDQVVKAVAERLRTCL
DQTDTLARLGGDEFAVLLE-CRQNHASSLAQRLLQSMSAPFDIQGQRVYVSASLGISLFPDDAGNVDHLLQHADAALFQAKASGRNLYAFYTPELTARAR
SHVEVESALRRALEQDELRVHYQPVHDLATGRPVGAEALVRWQHPQRGLVPPGEFIPVAEECGLIGALDTWVLNQACRQMRRWLDAGSE-EFVAVNLSSR
LFAREGIEQQVARALADSGLQARHLELEVTESAIMQNIDQSVALLQRLRDLGVQLAIDDFGTGYSSLMRLKRMPVQKLKIDQGFVAGLPGCAEDVAIACA
IIALARSMGLKVVAEGIERADQATFLLSQACDYGQGYWYGRPQPPEALPLNQ--------
>tr|M4X2J3|M4X2J3_PSEDE Sensory box/GGDEF domain/EAL domain-containing protein OS=Pseudomonas denitrificans ATCC 13867 GN=H681_23855 PE=4 SV=1
----------------------------------------------------------------------ATLSALSDREERLNRALNVVEDGVWDWDLR
THRVYYSQGYANLIGLPSERL-SDDFLW--NRLHPEDRSALAAYQEH---------CVYRILHSHGGYRWIHSRGRVE--ADGEALRMTGISRDITRQRS
NEDHLR---AVFEATQEGLLVTDSRGIIVHINPSFSRITGYQAEDVLGAQP-ILKSGRQGAAFYRRMWESLLRDDVWSG----RRKSGEVYPQWQHIRAV
RNEQGELTHYVAVFSDLSSLKRSQHELDFLAHHDPLTGLPNRLLLRERIEQALARAEREQGGGALLSIDLDHFKHINDSLGHSTGDLLIKAVAERLQTCL
DERCTLARLGGDEFAVILE-SPRQHASSLAQRLLEAMDPPFEVNGQTIYMSVSLGVSLFPEDARNVDHLMQHADAALFQAKASGRSLYAFYTPELTARAR
SHVQVEAALRHALDHNELRIYFQPVHDLLSGRMIGVESLVRWQHPQRGLVSPSEFIPVAEECGLITALDAWMLDQACRQMRAWLDTGIA-DYIAVNVSSR
LFGRGGLEQRVALALEQSGLEPHHLELEITESAVMQNFDQALELLCQLRLLGVHLAIDDFGTGYSSLMRLKRMPVHKLKIDQGFIAGLPDEAEDAAIACA
VIALGQSMGLRVVAEGIERPDQAAFLLTHACDFGQGYWYGKPQPAEALLAKL--------
>tr|G3J020|G3J020_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_3688 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------ARTGPV---MGLFNSERQNYFWVVVNSVPE--GERQPHQVLMTLTDITLQKQ
SEGKLS---VIFNNIGEGIFVTDKDKKIISVNEAFTTITGFTQQEVYGKNAHFLHSKKNSIKIDDELSNLTGTVNSWQG----RHKNTMDFPSWTTVSEV
KDSSGEVAHYVHVFMDITHFKKAQDHLGFLAYHDPLTRLPNRLLLKDRIDHSLQNALREGSQAAVLFLDLDRFKGINDTYGHAVGDGLLREVAKRIKNLV
RKEDTVSRYAGDEFVVFMENIPDKNPAKLAQKLIETFNAPVYI-GYRLKISTSVGISLFPQDGRDTDTLIKNADAAMYRAKKEGRNNFQYYSLELTTEAF
EKMSMEYALRQSIERHELILYYQPQVCLKTGKLVGVESLVRWMHPELGLMSPKQFIYIAEESGFIVALGEWVLQNACMQMRRWLDEGLQVNKMVVNVSAI
QFLRSDFIATVERILRSTGLEPSSLELELTGNGFMDNSEQTIKALNQLVALGIDLTIDDFGVGCFSFNNLKRIPVKKLKINSSFVVDVLNNANDEDIARA
VIALGHGLHLRVIAMGIESTAQQRRLMDLGCDEGQGHLYSSPVLPWSNRTLI--------
>tr|A4ACX6|A4ACX6_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Congregibacter litoralis KT71 GN=KT71_18916 PE=4 SV=2
----------------------------------------------------------------------YASPD-------------------------
--------------------------------------------------GMTLYF-ENRYRHRDGSYRVIAWSAA----TAERESVICAVGRDISQEHA
ARRGLF---AVFKNSGEGILISDKDGRIRDVNAAFSRITGYSREDAIGQPTSLLRSGRHDGDFYADMWQTLQRDGVWRG----RRKSGTVFPELLTISKI
DG---PDGGFMAIFTDISQLKETEEQLQKLAHYDPLTNLPNRFLVNECLEHSIRRAQRRSDHLAVFFLDIDSFKNINDSLGHFAGDKLLKTTANRLKALL
RDDDSVGRIGGDEFLMVLDDISTDDATHIAEKIIGALRKPMILEGRSISVSASIGISIYPEDGQTAETLMSNADAAMYNAKDQGRDTFRFYSEHLTRQAF
QNVLIDSALREAVSRQEFRLAFQPQVNTDNGSLLGLEVLLRWHHLTLGTVSPSQFIPQAERTGLIRDIGHWVLEQSCLQGSRWIAEGLQFGHLAVNVSAP
QFRAEDFVAQVRKVLADTEFPPEKLELELTESVLVHDTEKLIENMHELRALGVMFAIDDFGTGYSSLSYLKRMPIDRLKLDKSFVDHIVSDDSDRIIAGA
VLALGKAMGLPVIAEGIEQEAQARVLQSLGCKHFQGYLYGRPMYGPRIEVVL--------
>tr|E4PMH1|E4PMH1_MARAH Sensory box/GGDEF/EAL family protein OS=Marinobacter adhaerens (strain HP15) GN=HP15_4115 PE=4 SV=1
----------------------------------------------------------------------TRE---RQTQEALD----SFFTMNAMVDFE
GKFVRVNGLWETKLGYRRDELEG---------------------------EGSEFE--NRYRHKDGFYRWLSWSSV----TSPEAGLIYAVAIDVTEARI
ADDKLR---TVFQSTVEGVMISDLDNRIIEVNDAFSQITGYTEEEAIGKTPDLLDSGKHDPSFFNAIWQSVRENGHWRG----RRKDGSVFPELLTISTI
LN-KDEPVGYVTVFSDISTLKAHQEKLDYLAHHDPLTGLPNRLLFNSRLQQSIRLSERTGRSIAVLFIDIDRFKNINDSMGHPTGDELLKHVAARLREQL
RASDTAARLGGDEFVVLLEDIEGEHAGQVADTLMKAFKETFAMDGVEIGVTVSMGISLFPQDSNDAAELLADADAAMYQAKENGRNTYAFYSSESTARAL
EYVFFENALRRAVSDNQLFLEYQPQFDLEPGKLTGMEALIRWQHPDKGLITPDRFIPIAEQNGTIRNIGQWVLQTACHQGKAWLDAGLDIGRISINVAAS
QFHDENFLAEVLAIVDESGLPPEHLELELTESSFMHQPERAIPKLHALRERNITIAIDDFGTGFSSLSYLKRLPIDKLKIDRSFVMDLPDDEEDKAIVRA
IIGLGKTLKLKTIAEGVETEAQVAFFKQAKCDA-QGFYFSRPLGTDAMDAFL--------
>tr|B8GM77|B8GM77_THISH Uncharacterized protein OS=Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) GN=Tgr7_2589 PE=4 SV=1
-------------------------------------------------------------------------QKLDVARQEIRAIFDSMDAAVVVVNHD
GSIDDCNRQAREWLFDLDAQMLI-----LAELCPCDRE------IQQ-------------------SDI-----------SIKKVVI----CFDVTQQKK
TEASLGLYG--FESTAEGIAITDSRMRFLQVNEAYCRITGYSDGELLGRTPRMLKSGHHDAAFYADISKTLEVRGHWRG----RTRDGRVIPLLQTISVV
RDTQGAVSHYITIVTDISSIKETQSRLDFLAHHDPLTELPNRLLFTARLEHAIDWAVRNQAHFGLLFIDLDRFKTINDSLGHQLGDRLLVQVARRLRGLV
RKSDTIARLGGDEFVVLVEGIHNGEAELLAEKLVHAMRQPFFLEETELHIGCSIGITLYPEDGEDPVTLLKNADAAMYRVKDFGRDGFCKFSQDLAEAVD
ERLALETALRQALRENQLQVHYQPVIDLAQGRMVAVEALARWRHAERGEIAPCSFIRLAEETKLILPLGGWMARTAIGQFRLWRERGMELDYVSINTSGI
ELFDPGFVDGLFEALDEHGLEGRHLQIELTENVLMQDYEACRRVLLRLRQQGVRIAIDDFGTGYSSLAYLKQLPIDMLKIDRSFIKDVPGDPGDCAIVET
IIAMAHRLGLATVAEGVETEEQEDYLLAIGCERLQGYRYARPLDPVSLERLH--------
>tr|B9M6C9|B9M6C9_GEODF Response receiver sensor diguanylate cyclase/phosphodiesterase, GAF and PAS domain-containing OS=Geobacter daltonii (strain DSM
----------------------------------------------------------------------RAEETIRKAKELSEAINQLSLIMERILEKA
GHAIKADSAVIY-----------QLEERISSWGLPGI-V-IGEIYDP-----------KVAKTLSMTLKNY---------------------LLYEERQK
SEERY----YLFQNANDPIFIIDRELKFINVNRRAMDLFGYGLDEFVAMNMVDLVPEEQ----IP----------RIQGMEALDKLSTNIRTKWGYSLNV
EIERNNVMGSIHIVRDVTESKKMEDEIRYQATHDILTGLANRMLFMDHLALSISQGHRYNEIQAVMFLDLDRFKSINDSLGHAAGDKLLQLISGRLKECV
RETDTVARIGGDEYNILITQMAHEDATAIANKILSSMNKPFAIDGHQLHVTISIGISLYPTDGEDAETLLKNADIALYHAKEQGRNNYQFYNPALNTRTL
ERVKMENRLRQALERHELVVLYQPQVAMDTGQVTGAEALVYWLHPELGLLSPGHFIPMAEEIGFITDIDEWVLETACAQNKAWQDEGYRSFNVTVNMSSK
QFRRPDLVDQVRRVLNATGLPPRFLELEITEGTAMKDIEYTIPSLNTLTGMEVGFAIDDFGTGYSSLSCLKKLPIRKLKIDKSFIFGVNTDPNDKAIVAT
IIAMAHNLKLEVIAEGVEDADQLEFLHQNHCDQMQGFLYSRPIPAEDFRRLI--------
>tr|W4PYL9|W4PYL9_9BACI Diguanylate cyclase/phosphodiesterase OS=Bacillus wakoensis JCM 9140 GN=JCM9140_512 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------VVTGNRSEASGYHNHEFYINMWACIHDT----ERGLITNYIGTFTDITKMKN
NEQNLQ---QVFENAREGVMFTNKEGKIISVNPSFTETTGYTKTDVLGKTPRILSSGLHDVDFYISMWEEIHEKGSWQG----KKKNGEIYLESLSINAV
QESDGTIKHYVGIFTDITKKKKSEEQLKHLAHYDSLTGLPNRFYFQEKLKEELDKRQKQDYLTAVLFLDLNGFKMINDAFGHSIGDELLKAVSKRLEISI
EKKGFVARLGGDEFTICLTKVHNNEIKQIVNELDKAFSAPFHI-NQEFFIRLSIGVSLYPDDGQDVDDLIRKADLAMYVAKKQGKY-VEFHQGGFDISGE
SKLTVVNGLRKAIERDELVLFYQPQFNLKTNEVVGLEALLRWNQKGVGITSPATFMSIAEETGLIVPIGEWVIKRVCNQVMNWKEKGLPFTKVSINLSAR
QFVDASLITFLTDVIHETKVDPTYISLEITESISMHSIDYAIKTLEAIRLLGFSVSVDDFGTGHSSLSYLKRFPVNALKIDRSFVKDIWREKENAAIVQA
IISMAKGLKLEVIAEGVETKEELSIIKQLGCTYGQGYYFAKPMSCLEVDHFL--------
>tr|F1VY99|F1VY99_9BURK Uncharacterized protein OS=Oxalobacteraceae bacterium IMCC9480 GN=IMCC9480_2501 PE=4 SV=1
------------------------------------------------------------------------EELQRDSDLRYRSTFDLAPVGIVHTTPD
GDITLANPRFGAMLRLSGPAL-P-----ITDMVAGEDRD-Q---MQ--------------------SLV----------IPRHLLAL----IEDISLRKE
MEQALRESEATIDALSEHICVVDETGRLLAVNKAWANYGNDSD-EVTAIDWRAAASGLEDGQGMRAVLAGTQE-----D----YRCGTAARPSWFLARLT
RFPLDGPMRIVVSHEDITDSKLAQKHLTYLAHYDNLTGLPNRVLFYDRLKQVLLQAERSNWTVGVMFIDLDHFKAVNDTLGHAAGDTVLQQASRRILDSL
RANDTVGRLGGDEFGVFLPDLATQDAAMLAGKITQALSLPFVIAGTELFVTPIIGITLYPRDGNTADVLISSADTAMYRAKELGRNGHQFFTPHMTARMS
AQSRLESGLRKALERQELSLHYQPQVDIASGRITGVEALLRWHHPEMGIISPAQFIPIAEDTGLIVPIGAWVMQAACLQNMAWQRAGLAPIVMAVNLSAR
QFKHNDVETMVREVLQDTGLDGSYLELEVTEGIVMENTEALIATMDALKAIGVRLSLDDFGTGYSNLVYLKRFPLDTIKIDRSFVSGIGQ-GDDAVIAAT
VITLGHHLNLKVIAEGVETPDQRNVLQQLGCDIMQGYLFSRPLTAEATTALL--------
>tr|W0DKL7|W0DKL7_9GAMM Diguanylate cyclase OS=Thioalkalivibrio thiocyanoxidans ARh 4 GN=THITH_03900 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------PP--------------ATRGNPMTWVRLQARAD----MGHR-ALIVATDFRDLGV
SPDEMQ---SVYRVLDHAVMIADGENRIVSVNPRFTEITGYPPDEAIERKTNLLKSGRQDDAFYQRMWHALETRGRWQG----RRKNGEEFLESLSIHTL
HDREGRVLRRVALFSDITDQRRAVEEAQRQANHDPLSGLPNRNLFLDRLEQEVRKGQRNARSVALLYLDLDHFKEVNDTLGHQAGDRLLQEVARRIRASV
RETDTVARLGGDEFTVIMGDL--DFVDLVAQEIVDALARPFPLGEVV-QVSASLGIAFFPADADGSAELVDHADRAMYAAKKAGRNRYQYFTPQLQSSLR
ERHRRIAELRNALSNRQLQVYLQPVVDLLSGETRLLEALLRWQHPDDGLILPAQFLPLAEDIGIMGEIGDLVFEQVSAVVGAAEPSHAENVRIAINQSLR
ELCHGRGERGWVGYLEEYGLPLDRVVFEITERTLLEGGTMVESQVCREIEQGVSVALDDFGTGQSSMTCLERIPFEYVKLDGSVVRRLPHDRPARAFLEA
VIVLTGSLGIRLIAEGVETEAERDYLRASGCRFAQGFLLGPPVPAEFCRYLS--------
>tr|G3IVQ7|G3IVQ7_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_0577 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------ISDNLVP--------------QVGGIP-IWVSIEATVD----SRKT-CLASMIDISEQKR
NVQELQ---TIYLALDEAIMVADANNQIISVNEAFTRLTGYTAAEAINQSTSLLKSGRQNEAFYQEMWHLLNTTGHWQG----LRKNGGEFIGWLSISTI
YSDTGEVVHRVAMFSDITDKKQTEDIIRKQADFDLLTGLPNRRLFYDRLQQAIKKAKREGQKLAVLFLDLDQFKDINDTLGHEIGDRLLNEVAQRLDACI
RDSDTLARPGGDEFIIILDNL--EFIERVANCILGSMALPFQLEESC-YVSLSIGITLFPDDAVVVDELVKKADQAMYAAKRQGGKRFCYFAPSMQAAAD
SRLRITNDLRNALANQQFWVAYQPIVDLATGDIHKAEALIRWQHPTQGLISPAEFIPIAEDTGMIVEIGEWVFHQAAKQVLKWRSKH-HPFQISVNKSPV
QFEQHDNINGWFEHLQHLELPGASITVEITEGLLMDASSIVSEKLLIYRDTGMQVSLDDFGTGYSSMSYLKKFDIDYLKIDQSFVRNVTTDSTDRTLCET
MIMMAHKLGMKVIAEGIETAEQRDFLMQAGCDYGQGYLFSRPVPAEEFELLF--------
>tr|G4SWK9|G4SWK9_META2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 /
----------------------------------------------------------------------------------------------------
----------------------------------------LSKMSAA--------------KIAGRL-IWIEIKAIAD----LLQT-CRASVSDITERKQ
TERRLQ---MAYQAIDEAILITDASYRIVAVNPAFTKLTGYTEEEVVGQFAHFYKSECHDSRFYLNIWKALRKTGHWQG----RRKNGEIYLEWLRINTN
YDSNGKVLQRVAISTDITDRKRAEETMWKRANFDQLTCLPNRYLFYDRMQLAIKQAYREGRTMALMLLDLDRFKEINDTLGHDMGDSLLLEIARRLNHCV
RETDTVARLGGDEFAIILNEM--DRIERIAQGILQQLAEPLLLNKKV-NISASIGITFYPEDASEIETLMKNADQAMYDAKEAGRNRFSYFTHTIQETVR
SQAILDNDLRDALADNQLQLHYQPIIELASGVIYKAEALIRWRHPQQGWLNPTDFIAVAEKTGLIVEISDWVFKEAARQVKLWRRYF-DKFQISINGSPM
LFHGSEHQNSWFEHLQQNGLTVDSIGVEIGEGLLLDTSHAISSTLSSFCEIGMPISIDDFGTGCSSLSCLQKFHIAYLKIDRSFVSQLLNQSNKIMLCEA
MIAMAHKLKIKVIAEGVETHEQREQLEKMGCDFAQGYLLSKPLSAEAFDTLL--------
>tr|W6M0U1|W6M0U1_9GAMM Putative Predicted signal transduction domain protein OS=Candidatus Competibacter denitrificans Run_A_D11 GN=BN873_100024 PE=4 
----------------------------------------------------------------------------AWRVDFQRVLIETLPVPFIVEDTK
GHCLMANPAFATLQGEDAAGVAD-----AESRS---------RVPQP-------------------AMF-----------ETGVISV----LIDITERKK
NEENRRLAE--FQNAADAIMVTSATGIIKSINPAFSTITGYGREEVMGLTPRLLRSGRQDNQFYAAFWASLRQYGKWSG----RRKNGEVYPVWETVAAV
RSPEGRIIEYVSFFNDITARKQAEQEIFYRANYDPLTGLPNRSLFHERLEQALKQARRYDRRVALMFADLDRFKQVNDTLGHSFGDQLLGQAALRLEACV
RDTDTVARQGGDEFVVVLPNVIERDAGVVAEKIISRLREPFDLSGNIVHIGVSIGIALYPDHGDNSEDLVRHADLAMYQAKLAGRNTYRLYESAMADELN
RQLMLETDLRTALQKNELELYFQPILKVEDKSLVRAEALLRWFHPRRGPVAPGEFIPLAEETGLIRDIGLWVFERACQTLEKWHELGLMIP-LAINLTSA
QVFRGLSLEVVSSLLERYHLAPESLVFEIAEGVLLADSAQARQWLKSIRQLGICLDLDDFGTGYSSLSCLKRFPIDRVKIDLSFVRDMVLDLDDRALVEA
ILALSRSLRLEVVAEGVETQEQFDLLRALGCGYAQGYYFSHPVSADAFVEVA--------
>tr|Q1JX80|Q1JX80_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_0921 PE=4 SV=1
---------------------------------------------------------------------------------QYADLLENSNDLIQVVGFD
GRIIYANR----------------M--WGYGKNDLTQLN-F---FDL---------------AEGSIS-----------PGI--QGF----FRDITARKK
TEKALQTSETIYESSVAGIAMLAPDGHFLQANSAFCNFLGYNEEELLQMKITDV--THPD--DIEDTLSRLHSIVCEK-----IRKDGSVFWAQLSSTWF
FDANGNPLYTVPVIQDITRRKEAEERIRELAYYDSLTGLANRTLFNDRLDQVMARSRRRQSRFALMFLDLDRFKGVNDTLGHAVGDAMLRQAAERLNECL
RENDTVARLGGDEFVIILSDYKEANLPRVADKILKALSSPFDLGVREVYSSTSVGIAIYPDDGDEATDLLRHADMAMYAAKESGGDTFRFYSSEMNARAV
SRMDMEANLRRALEQEEFFIEYQPQIDLITNKVAGVEALLRWQHPQLGVIPPTQFIGLAEETNLILPLGEWVMRRVFEQCVMWKQEGYLPFRVGINVSGR
QFVQPDFVDMVCRLLDETGAAPELLEFEITESVVMKDVDAAVLTLEALKKLGINMAIDDFGTGYSSLSCLKHLPLNRLKIDKSFISDLQDNADDRAIVEA
TIAMAKRLELGVTAEGVETEGQYGFVQKRECDEVQGFYFSRPLSPSEVADAW--------
>tr|B3EBJ4|B3EBJ4_GEOLS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) GN=Gl
-------------------------------------------------------------------------------DTPYKQVFSAIPAPVIMLDTQ
GHFAFANK----------------A--AP-----------S---CIP---------------QFT-LT-----------QGI--LIT----LHDISRHKR
AEQALRLSEMLVEHQSDLVVRVDIEGRLQFASPSFCMLFGIDEEQLVGRELCPI--INSSGAVMKEAMQRCHPKSCYH-----SQTLDGLRWIGWAMKGV
VDEKGHIEAIVGIGRDITDRKKAEQEILQLAHYDTLTGLPNRSLLQDRLSQALSLANRGNVTLAVLFLDLDRFKHVNDAFGHQIGDLLLQEVSRRLKDCV
RATDTVSRIGGDEFVIILTNLIKSQAGSIAAKIISSMSRLFQLGGHELYSGTSIGIALYPTDGNDVDTLLKHADMAMYQAKASGRGTFKFFSPEHNEKML
QRMQLEQALRRAIEHQELSLDYQPQIDSATGSINGLEALLRWQHPQLGLLLPGLFITIAEETGLIIPLGEWVLRTACRQARAWQRAGYHRLRIAVNISPR
QFQQRGLIPMIDAILQETGCDPRGLELELTETTLMDSPKEATALLKALKRRGISLAIDDFGTGYSSLSHLKHFPIDRLKIDRSFVNDLTRSREDSAIVEA
IIAMAHRLGLEVVAEGVEHPDQHAILSDWGCKTCQGFLYSKAVSTEEATALL--------
>tr|A0A031GVF9|A0A031GVF9_9BURK Uncharacterized protein OS=Janthinobacterium lividum GN=BW37_01297 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--ARQIEAESARLLLYHASGHTL-------AALLP-------------------------------NSV---------AAQFANLRL----SEDIAARMH
NEKSLRLRE--IEVSANAIILCSAGYLIEYVNPAFERITGYAAGEVIGQRLEDLQGPEQGRQDMHAITAALREQREGKA----FRKDGSCYWSELFVAPV
RDGDGPVSHFVVAQYDISSVMRFEQELEFQARHDILTGLANRALLRERLEQAMAVTRRSGQPLWVVFIDLDRFKFVNDTLGHDAGDLVLKNVAERLRDAT
REVDTVARLGGDEFVLLLPQHGNEPGAAILQRIQDAVAQPLQLGEYEFFLSCCMGVAVYPDDGQNADTLIKHADIAMYRAKEQGRGHWQFYASSMNAGTL
ERLELESELRHALERGQFHLEYQPQLDLASGAVVGMEALLRWQHPQLGRVPPASFIGLAEEMGLITPIGDWVLRTACAQARAWQLAGHGPLRLAVNLSAR
QFKQKNLLHAVAQVLADTGLAAAHLELELTESMVMHDVEQATTIMAKLKALGVQLSIDDFGTGYSSLAYLRHFPIDVLKIDKTFVSDITHSMDDAAIVRA
IISLAHSLRLKVIAEGVETEQQLAFLRQHGCDQMQGYLFSRPLAAAAFETLL--------
>tr|Q1K3I2|Q1K3I2_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_2858 PE=4 SV=1
----------------------------------------------------------------------S-TQRNANHDSQFYAFFQHGGAGMYSYDTA
GRILNANPAFCSMIGYSEHELKS-----ILDVTPPQVRD-E---TLN---------------------------GSTL-ISDNDSIYAVALVQDITEHKN
ADQAVLKERTVIDGIADPIMAISTDYHVILANRAARESHPEH-ALQPGPTLCYQLSHGSDTNQKCPLCQVKTGKEAR------HLRAGHEKTYEIKASPL
YNEDHSIRGIIETSRDLTDILNSTQHLQFVTTHDQLTHLPNKELFFDRLERATFKTHRSPFFTALLFIDLDRFKHINDSLGHEIGDQLLQEVAKRLSTSI
RKTDTLARMGGDEFLIIIEDIKESHVSTVAKNFIDTILPSFTIDGHELFITPSMGISIAPTDTQHPKELLAFAEIAMYQAKGLGGNKCQFYTAEMNSRAK
TRIELESYLRKAVNQDQFVLYYQPQFDIQSGELVGCEALLRWQHPQMGMISPNDFIPLAEETGVIIEIGEWVLQEACLQNKKWQDAGHSPIRVAVNISPR
QFREPGFLEMIERVVQTTGIKPEWLELEITESLLMDDIDSAINILKQLKAKGIHLAIDDFGTGYSSLSYLKRFPLSRLKIDRSFVRDITTDDNDASITKA
VIALAHSMNLKVVAEGIETQEQLLFLKEKGCEVGQGYLYSPPVAKEPFDHFF--------
>tr|B4W5F5|B4W5F5_9CYAN PAS fold family OS=Coleofasciculus chthonoplastes PCC 7420 GN=MC7420_648 PE=4 SV=1
----------------------------------------------------------------------QAEVALRSSEAELRALFAAMTDSIFVLDSQ
GCFLKIAPTNPDP-------------------------------------------IEYS-LTVRDREVWFAATISPT--DS-----VVWVARDITERKQ
AEQALKQAESIFENALEGIFQSTADGHYISANPALARLYGYSSPDELMVRLDL---YVDPQRAEF--SR------LLQEESQVYRKDGSVIWIAENARAV
RDMTGELLYYEGTVEDITEHKLAKDQLQTRAFYDTLTGLPNRALFMDRLSHTVERAK---PRFALLFLDLDRFKVVNDSLGHLVGDQLLIGIARRLESCL
RTEDTVARLGGDEFTILLEDIEDHHATRVAERIQQELAAPFNLDGHEVFTGASVGIVLSRENYDCPEDLLRDADTALYRAKALGRSRYEIFDLTMHQNAL
SVLQLETELRRAVENQEFEIYYQPIVSLSTHQIAGFEALLRWHHPSRGLVYPGEFIPMAEETGLIIPMGWWMLRQACRQLELWHDTVQEHLTIYVNLSSK
QFLQPELLEHLDKILHETHLHPSHLKLEITESCLLADPEIAEERLKELRDRQIGLCIDDFGTGYSSLSYLHRFPIDTIKIDQSLISNISIDVQPLQIVRT
IIMLADSLGMKVIAEGVETKEQLTQLRLLDCDYAQGYLFQAPLDALTAGKLR--------
>tr|D8FVJ8|D8FVJ8_9CYAN PAS fold family OS=[Oscillatoria] sp. PCC 6506 GN=OSCI_860001 PE=4 SV=1
----------------------------------------------------------------------MAEEQLRASEAELKALFAAMTDIITVRDRL
GRCLKIASTNPSL-------------------------------------------FEYS-LPIDNADMWFAVTVSPI--DS-----VLLVARDVTKYKR
TEEALRQAESIFENAVEGIFQTLPNGRYISANPALARIYGYNDAAELIDKLAL---YVDPNRAEF--TG------QMQLESQVYRSDGQPIWVSESARAV
RGKNGELLYYEGIVEDITERKRVEDELLHNAFHDALTGLPNRLMFMERVSLAIKLAK---SRFAVLFLDLDRFKVINDSLGHMVGDQLLIAFAQRLQGVV
WVSFTIARLGGDEFTILVEGIQDSGATEIADRIHKQLSLPFNLNGLEIFTTTSIGIVLNWDIRHSAEDLLRDADIAMYQAKARGKARSAVFDQAMYAGAV
ARLQLETDLRRAISAQEFQVYYQPIVCLANGRISGFEALVRWQHPHRGLVSPSSFIPLAEETGLIIPLGSWVLWEATRQMRAWQLQFQSPIAISVNLSGQ
QFSQPDLIDKFKQILQETGLEGSSLKLEITESVITEGAGNARTILKRLRDLNIQLCIDDFGTGYSSLSRLHHFPINTLKIDRSFVSRMGKTGRLGEIVQT
IVMLAHNLGMDAIAEGVETAEQLAQLKLYNCEYGQGYFFSKPLTSIAATAML--------
>tr|K9Z340|K9Z340_CYAAP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cyanobacterium aponinum (strain PCC 10605) GN=Cyan10605_1517 PE
----------------------------------------------------------------------------------------------------
--------------------------------------------------------IEYRIFTKDNQVKWLWEKGKGI--ESGQLLGIEGIITDIGDRPC
TEKLLSQVENFFENAVEGIFQTTIDGYYLSANKALAKIYGYDTPIQLIKNLDL---YVQPHRKQF--VQ------LLEEESEVYRSDGTTIWISENARAV
RNVKGDLLYYEGTVEDVTKYKLAQEKLHRQAFYDQLTQLPNRSLFMQKLTQCLDKLK--SNQFSILFLDCDRFKAVNDSLGHGVGDLLLIAIGERLRNCL
GEKEIVARLGGDEFTILWDDIDNKEIINLAEKINNAFKPPFVINKHQLFCGISIGIFFSSSNYLSPPQILQYADTALYKAKSQKRSYYQVFQGDMHNEAL
AELQLENEIRQGLEAEEFILYYQPIINLTNNQLKGFESLIRWNHPQKGIVTPFHFINLAEQTGLIIPIGLWVLKEGCKQLDKWHNHILNP-IISINLSSQ
ELNSEKFLPTLDNILKETKVNPEYIKLEITESSPIFQEQSTQYILDAIVDRNIQLWIDDFGTGYSSLSYLHRLPINGLKLDRCFVTDIETNQKKAKMIKA
ILSLAFDLGVEVIIEGVETEKQLEIIQEMGCIWGQGYLFSHPLPPEKAGDIL--------
>tr|T2JCP6|T2JCP6_CROWT Uncharacterized protein OS=Crocosphaera watsonii WH 0401 GN=CWATWH0401_4826 PE=4 SV=1
----------------------------------------------------------------------AAQEALSKSEEKYRQIVETATEGIWMIDQE
DKTSFVNKQMAQM-------------------------------------------F--KFRCRDGRELWTIVSTNPM--HSGNYLGSLAMVTDISKRKK
MEQALSESEGILTSIQDVVWSCHADSRLIYINPAAQMTLGFCLE-ELYDNSLI---YPDDQLVQY--HR------QVVRKYRIRRKDGKIRWLSSRIRCV
YDEKGNIIRIDGIDSDITEQKQAEEQLQYNATHDPLTHLPNRILFMDRLEHAIERQK---PTFAVLFLDLDEFKIINDSLVHEIGDKLLREIAYRLQYGL
ENDDTLARLGGDEFTILLEDIEDKDAIKIAKSIHLDLMEPFVLEGQDIFINTSIGIALSSSGYEKATEILRDADTAMYRAKADAKSCYAIFDRKMHERAV
NRLQLETDLRIGSNKQEFSLYYQPIISLKTGQLTGFEALIRWHHPHKNLISPGQFIPVAEETGLIIPMGEWILKEACQQMKQWHNKFPQSLKIGVNLSSK
QLKYTNLLNMIDSILRETNLDTKSLKLEITETLLMENLQAATEILLNIQEREIEICLDDFGTGYSSLSYLHRFPVNTLKIDRSFVMRMEPNNENAEIVRA
IVHLAHILGLDIIAEGVETELQLEQLEQLGCEQGQGYFFAKPLPSLEVEKLL--------
>tr|Q118H0|Q118H0_TRIEI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Trichodesmium erythraeum (strain IMS101) GN=Tery_0665 PE=4 SV=1
----------------------------------------------------------------------LEDTLIQRSLQKKALIFEYLYDGVILTDTQ
GNIVDWNSAATRM-------------------------------------------GEINFIRKDGSEGICETTVVPI--QQNQMVGSIGVNRDITQQKR
AEAALKESERLVKNSPEAIAVNYM-EKIVYINAAGAKLFGANCPDEIIGQLRI---ETEKQQQVQ-----------EQGEEKLIKLNGEIIDV-------
-EILGIPYTYDGILKDITHRKKTQAKLVYDALHDTLTGLPNRALFFERLKLALCRSR---PQFNVLFLDLDRFKVINDSLGHTIGDRLLIAISKRLQNCI
KASDTLARLGGDEFTILLESPSNQDATKVAGRIHQELVRPIYLEGNEIFTTASIGIVTNRRIYNKPEDLLRDADIAMYRAKTLGKARHEVFDLTMHREAI
SLLQLENDLRRAIENSQFILNYQPIICLNTGIITGFESLLRWAHPTRGLIYPGQFIPLAEETGLIVPLGMWILRSVCHQLTTWQQECSTDFTVSVNLSSK
HLSQPNLLEEINTILEETNCQPSYLELEITETLIMENVSLATQILNKLKNKNIKLLIDDFGTGYSSLSYLHQFPIDSIKIDRSFVSRLDSDTSTCKIVGA
IIGLANNLGLEIIAEGIETRTQMQKLKKLQCNKGQGYLFSKPLEGEDATKLL--------
>tr|B4VXK2|B4VXK2_9CYAN Cyclic diguanylate phosphodiesterase (EAL) domain protein OS=Coleofasciculus chthonoplastes PCC 7420 GN=MC7420_1087 PE=4 SV=1
----------------------------------------------------------------------LTEQLHQQQEFNQ-NLVETHGGFFVAIDPQ
GKTRMMNPRLLET-------------------------------------------HQTGVLTKEGQELWVEWRSQQV--KSGELDFLFAIGRDQNEHCL
----THQETSFPLLTPNPIVEIDLAGRVRYLNPEAMRLLPELLD-----S------HP------F--LA------EMPSQSSLRRE-------VKIGEIV
YE--QVLHYVPEYALDITDRKRAEELLLFNAFYDRLTGLANRALFMDRLQQAGRRAQPSDPRFAVVLLNLNRFKVVNESLGNHLGDQVLQEFGQRLQNCL
RPTDTVARLGGDEFAILLEGIQGCDAIQVADAIEQTLTLPFNLEGRDVFMTTSIGIALNTNQVLSAENILRNANTAMHRARSQGKPGYAIFDNQMLSPTV
DRLQLETDMRRAIERQEFQVHYQPIVSLLTHQITGFEALLRWQHPQRGLVFPAEFIPIAEETGLIIPMGWWILREACRQLSIWQQQFQSQLTMNVNLSCK
QFTQPDLLAQIDQILEETNIAVGSLKLEITESVVIDNPELVKDLLLELKKRQIHLCIDDFGTGYSSLSRLHNFPISTLKIDRSFISRIGALGENSEIVQA
IITLARTMSMDVVAEGIELLEQVSPLVALQCHYGQGFLFSKPVDSDGAIKLL--------
>tr|A0A063B1W3|A0A063B1W3_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. lig30 GN=LIG30_0509 PE=4 SV=1
----------------------------------------------------------------------QLRE----REAT---LLEMIPVPVFSKNRE
GRYLYLNKAFEEFLGRDKA-HFI-----VFEAHQHELAS-T---YHA---------------EFTKSVFRDRE-GTP---GL--IGAILDVQAALQLNQR
LEGELEDARGVLQTIPDFVWLKDTEGVYLFCNPAYERLIGKPEADIVGKSDCDFYSEEEAACREK-DLQAEAGRICIN-----TYPDTGRRLLETRKVPM
RAADGRVKGVLGVARDITERKRFEDTLHRMAYYDPLTSLPNRTLFNERLRQTVADALPDRPLSGVVMLDMDRFKDVNDTFGHAAGDELLREAAKRLLPCV
RPGDTVARLGGDEFAILLPDVRERTLENIAKTILRQFDAPFELDGKGVFVSCSIGIALYPNDSAEAGDLLKYADSAMYFAKQSGRRNYRFYSKELTVHAA
KRLAVESELRGAIERGEFELHYQPKVSLDSNEVIGSEALLRWNRPGMGLVPPDEFIPVAEETGLIGDLGTWVLREACRAAVEWNANGRGCHTVAVNLSAR
QFQFQDLASTVEEILVETGCHPEWLGLEITESVLLEEDDAILAALWTFKTMGLSIAVDDFGTGYSALSYLARFPIDVLKIDRSFVQKVTTDRRHAELVKA
ILSIARCLGQQVVAEGVETDAQAAFLLANGCQVAQGFLYSKPLPKGRMTSLP--------
>tr|S2L7D4|S2L7D4_9GAMM Uncharacterized protein OS=Halomonas anticariensis FP35 = DSM 16096 GN=L861_12725 PE=4 SV=1
----------------------------------------------------------------------YRERDLREALELVEGIINAIPDVLFEVDRD
GTYLNVWTKNPDMLAAPKEELLGRT---VHEVLPPEQAVDLKAIA-----------EEWITHHLTGQPVLLETRKVPV--AHGRMTGVLGVGCDITERKR
MQSALAARETLVEHSPDMVARYDRDLRRLYVNPAFAATLGDDMAALLGKTPE--CPGGSYAIYEQNMSEVETAKGR--------DRSGREL---------
CHEDGSVESVLMVGRDITELSDSRQKIHRMAFYDSLTSLPNRALFNDRLQQMIVDASWHGQMAGVMLIDMDQFKAVNDTMGHAVGDELLREAAARLSACV
RSYDTVARFGGDEFAILLPEVRHDDLARIADKILGKFEECFLLDGREVFVSCSIGIAVYPDDSSDAGDLVKYADAAMYFAKRSGRNNFRYYSKDLTASAK
QRLTLESELRRAAERMELELHYQPKVSLDDGAMVGSEALLRWCHPRLGMVPPTQFIQIAEDTGLIVDLGQWVLREACRTAAKWNAAG--AHKVAINLSAR
QFQSQNLAGVVADILNDTACRPEWIELEITESLLLDDNGKTLDALSELRSMGVSIAIDDFGTGYSALSYLARFPIDTLKIDRSFIQSVITDHYGAELVKA
ILSIARSLGQQVVAEGVETIEQAAFLAAHGCQLAQGFLYSKPMPEAEIAALP--------
>tr|Q60A84|Q60A84_METCA Sensory box protein OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN=MCA0984 PE=4 SV=1
----------------------------------------------------------------------QAEV----QAGKALDH---LAEMVSICNAE
GRFVYVNEAW------------------ALGYRGEEFLN-L---SVA-----------------KTSAQWETI-HRTR-YEHEGCGYVLAL-RDTRLLKR
TDTALLRRESLAENSPDSIMRYDRDCRIVYLNPSLENTLLFSASDMIGRTPTELHPGDERFTYESKLRAVATGKADEI-----QGTHKGPRLLHIRLVAE
HDPDGECTGVLAVGRDITEVDEYRRRIQRLAFFDPLTDLPNRALLNDRIRQCLTDAAARGSQFGLMLLDLDRFKEVNDTLGHSAGDRLLCEAARRLNACV
RGYDTVARLGGDEFSILLPVVRDGDLRAIAGRILEAFGEAFIIEGKELFVSVSIGIVLHMEGQCDADRLFKQADLAMYHAKRQGRNNFQFYAEELAVQVS
DRTAMEGALRKALGNGELELYYQPQVALPAGRIVGAEALLRWRHPQEGIMTPDRFIPIAEETGLIRDLGHWVLTTACRRAVYWHRTVDSPFKVAVNLSTR
QFVRNDLPGELQRIVQDTGCRPEWLELEITESLLLGNDAEVGAALEELHDMGFAISIDDFGTGYSALSYLNRFPLDQIKIDRSFIQGFPADREKVELVKA
IISIAGALQLEVIAEGVETSHQAEYLHAQGCRLAQGHLFGRPLPQDRFERLL--------
>tr|A0A0C2I8I0|A0A0C2I8I0_9PSED Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudomonas batumici GN=UCMB321_2971 PE=4
----------------------------------------------------------------------HPEQQLLSDKQT---LAEHTPDTIARYDRN
LLRTYANPVFVHMIGLPETAVLG-----SHASNTPEILA-----YEA-----------------------------Q--AGE--VTSVLAVGRDITGLRR
AEQALRLKETLVENSPDVIVRYDLEGRRVYVNPAYEQLYGIALSDVVGTPISHRGPLSEELRYQKGIMDVQSARPVAL-----TRANGEQVVQHVRAVPE
FDSHGQVASVLTIARDISEIKAYQQQLHTMAFYDSLTALPNRELFKDRLHQAITHASRYNRQVAVAILDLDNFKVINDTLGHSAGDDLLQETARRLQRAV
RDSDTVARLGGDEFALILPLA-TVSLNALAGKLLQAISGIYPIRERELFISGSIGIACYPGDASTISELLQYADSAMYHAKEQGRNNVQVYSAQLIQTTT
ERMALAASLRDAQPNGELEVHYQPQVDLASGRLIGAEALLRWNHPRHGPVPPDTFIPIAEETGLIVGIGEWVLRKACQVAVAWNRDDRHPLKVSVNLSPR
QFRMNDLANSIRVILQDTGCEPGWLTLEITEGLLLDNNIAVREILERLFAMGLTIAIDDFGTGYSALGYLSRFPVEVLKIDRSFIRGIDHHRESVELVKA
IISMAHALGMALVAEGVEEPSQEAFLQGSGCHSAQGYLYGKAMPREDFEQLL--------
>tr|C6XBI7|C6XBI7_METGS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylovorus glucosetrophus (strain SIP3-4) GN=Msip34_2720 PE=4
----------------------------------------------------------------------I-TA----REKT---LLDNFPFMVWLKDTK
SRLLAANTEYARVAGVSSPHELE-----DFDFFDPELAK-E---YVE--------------------------------IGT--LGY----ARDVTD---
----AIRRESLIENSPNLIVRFDTACRRTFVNQKTANLYGVAEDVLLGKTPSEFPGGDSAYGYEQVVKEVKSGRSAAM-----HAPDGNSRIIHIWLAAE
LDASGLPIAVIGMGQDVTETYEYQERIHHLAYFDTLTKLPNRALLIDRVEQTIAEAERHAYPFGLIMLDLDRFKEINDTLGHTLGDVLLCEVASRLEKCV
RPYDTVARLGGDEFGILVSEMRVENITRVADKVLQAFDQPFVVDGHDVFVTASLGIAAYPSDSQAVDDLLKYADSALFHAKHLGRNNFQFYSADLTIKAA
ERREVETNLRFALKKEEFLLHYQPLVDLATREIIGAEALLRWQHESGKLIMPDKFIGIAEETGLIIPIGEWVMRSACQVAVALNRGRPRPVTVAVNLSTR
QFLHNDLVSSIQAILAETGCHTDWIKLEITESLLLENTDNIQRMLQSLSAMGLCISIDDFGTGYSALSYLHRFPVRELKIDRSFTSDITDNAERALIVQA
IVSLARNLNKNVVAEGVETLEQADYLHKMGCPQAQGYLFSKPLPLEQFLALL--------
>tr|C6X8Z9|C6X8Z9_METGS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylovorus glucosetrophus (strain SIP3-4) GN=Msip34_0371 PE=4
----------------------------------------------------------------------I-RR----REQA---VLNTFPFMVWLKDKQ
SRFLATNRAFADVLQIAHDEDMR-----DFDYFPHAMAE-G---YVA--------------------------------VGT--VGF----ARDITAERW
LEAEIARREMLVQNLPLTVVRYDRECRRVFVNSYCAMKESLKHNQVIGKTPMEFWSGSIVNEYQQRIMAVASGESDTL-----Q--YGEEQVHLVRIVPE
RSASGAVMGAMTVASDVTENSRYRKRIEQLAYHDILTELPNRLLFNQQLQILIEQTPINKHGFCLLFIDLDNFKTINDTLGHSVGDKLLIEVSRRIRQLL
GKDDMLARMGGDEFAISLPHCLSLDAALLAARIIDALNVPFEVSSIKFFVSASMGIAFYPEDSSHLDDLLKHADLAMYHAKRQGRNNFQFYNQELTVNAA
ERLLMENLLRQALAKGELQLYYQPIMELATGELHGAEALLRWNSFDLGMVGPDKFIPIAEERGMIVDIGAWVLREGCRTAVAWNALRSQPCVLAINLSSR
QFMQQDFLSRITDCLQETGCHPQWLKFEITESLLLHDSDHIRQTLEALHSIGITIAIDDFGTGYSALGYLNKFPVSQVKIDRSFISDIATNTESALLVKA
IIAMADSLGKELVAEGVETAEQAKLLSQLGCQYVQGYYYGRPVPLETFNQSL--------
>tr|D7DLT4|D7DLT4_METV0 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylotenera versatilis (strain 301) GN=M301_0381 PE=4 SV=1
----------------------------------------------------------------------I-RR----REYA---LLDTFPFMVWMKDKE
SRFLACNDAFAKVAKQLSVHDLE-----DYDYFSAEAAT-S---YVE--------------------------------VGT--VGF----ARDITKEQY
LQAQVAKRQTLVKNLPITIVRYDLDCKRVFVSAHCDEQYGVSDKVYLFKTPEEEWSPYILNEFTQRLQKVQTQKKQSF-----K--HGGAFVNQVKLIPE
YDEHHNVTGALTIATDITENAEYRQTIEHLAFHDVLTDLPNRRFFNQALNKAIERAEQHQAAFAVLIMDLDHFKTINDTMGHAVGDKLLIGVADRIKQNV
DDSYFFARMGGDEFAILIHGYESEALIAKSASLLEQVVQPYYIAGAGYFVSASIGVACYPKDSRDVDDLIKYADSAMYSAKQKGRNNCQFYSPTLTADMR
YQLEIETALRYALSNDELYLEFQPIIEMQTKRVIGVEALCRWVSAALGEVSPASFIQVAEESGLIVEIGQWIIKQGFIAAKIINEASTELISISINLSSR
QFVELNFLQRIKALLDETKCEPSWIKFEITEGLLLQDAYEVHRVLDAFDEIGIRISIDDFGTGYSALAYLNKFPIHQVKVDRSFINEITTNRSHALLVKA
IVAMVQSLGKELVAEGVETEAQASLLQSYGCQYAQGFLFSKSVGLDNLMLML--------
>tr|A0A0C1X0K5|A0A0C1X0K5_9CYAN Diguanylate cyclase OS=Scytonema millei VB511283 GN=QH73_20310 PE=4 SV=1
----------------------------------------------------------------------QALEAYTQCHPDLVLLDALMPV----MDGF
TCCGQLQ-ALSRSTALEDQESV--D-------------------------------QLAR--------------------------SNRELQTKINELHQ
AQKALQESRLIAQSAHDGLWDWSIRSNHIYYSPRWKSMLGYEEK-EIGNSLEI---HAEDKFQGE-LSA------HLAGEYRLLHQDGSYGWMLCRGLAV
RDSEGKPYRMAGSQTDITQNKAAEAKLLHDAFHDGLTGLPNRLWFMEQLEKAIHQTK---PQFALLFLDLDRFKVVNDSLGHAMGDRLLLEIATRLKACL
PSNSTLSRLGGDEFTILLENCDAR-VRQIAEQIHRELSTPFNLKGNEVFCTASIGIALSHSGYEHSEDVLRDADMTMYRAKAMGKARSEVFEPAIHDRAI
ARMQLEIDLRRALEHKEFMVVYQPIVSLNSGRVTGFEALIRWQHPQRGWVSPAEFIPVAEETGSIVPIGWWILEQVCQQLRTWQQHSVVSLTVNVNLSGK
QLTQPDLAREVKQILHKTGLSPSSLKLEITESVLMDNVDAAVAILQQLKTLGIQLAIDDFGTGYSSLSYLHRLPIDTLKIDRSFVNDIDCDPEKIEMIRT
IVSMAWNLGINVVAEGVETKKQMYQLQALKCDYGQGYFFSRPVDAEAAKTLQ--------
>tr|E1IIA6|E1IIA6_9CHLR Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Oscillochloris trichoides
----------------------------------------------------------------------DALALLRIQNFDLVLLDMVMPE----VDGA
MVLRVIK-HDPHLSGDTNIEHV--V-------------------------------QERR--------------------------QRAELERQI---AE
RAVELERSELAARGANDGLWDWDVPNNHLFLSTRWKSMLGYRDE-DIGNNPEI---HPDDQFKVR-LAA------HFRREYRIRNYDGSYRWVLCRGLAV
WDENDQVLRIAGSQTDISLRRAAEQQLQHDALHDLLTGLPNRGLFLDRLERAITISR---PRFAVLFIDLDRFKTINDSLGHTAGDQLLIAVAQRILGCL
RPSDTVARIGGDEFTILIEDIADQMIQAIVERIHASIAEPIQLGGHRTISTASIGVTTSDLQYTSATEMIRDADTAMYHAKMGGKARHVIFTPAMHAQAM
EKLQMESDLRGALGAGELRLHYQPIMSLEHGTVIGFEALIRWQHPQRGLLYPGAFLDIAEETGLIVPISWWVLRTSCLEASNWQREFPGPLSVNVNLSAR
LFAEPSIVDQIADVLAESGIPPSSLKLELIEHSLMTLSNQTSDVLRRIREMGVQLCIDDFGTGYSSLSYLHSFPVSTLKIDRSFINRMGPLGEQGEIVQT
IIGLARTLNLDVVAEGIETEQQYQQLRDLQCGLGQGLLFAPGLDSEGVRALL--------
>tr|L8MT87|L8MT87_9CYAN Response regulator receiver modulated diguanylate cyclase/phosphodiesterase OS=Pseudanabaena biceps PCC 7429 GN=Pse7429DRAFT_36
---------------------------------------------------------------------------------DY-----RLPS----FNGL
QAFDFLKQSGQDITGSLGEEAA--VEIK--TDYVLKDRLFLPSVLER----------------------------------------I------------
-----SKNN------------------ENVIGLSCDFYAHFRDELIQGEQILI---KDLAAYSIH----------SLLLTYSLYQCDRERVWSDNEISLV
KAAIHQSALYQSAQSELSERKKMEAQLRHDAFHDTLTNLPNRSLFLDRLNHALQLSNRRDSLFAVLFLDLDRFKMINDSLGHLAGDQLLKIVAKRLVACL
RGGDTVARLGGDEFVMLLEEIESNDVIEVAQRIQDSLKVPILIDGNEIFISTSIGIALNSAGYTQPDQLLRDADTAMYRAKEQGRDRYEIFNPAMHTEAL
KKLRLENDLRRAIERQELCLHYQPIVDLQLHKIIGFEALVRWQHPEQGLIAPADFIPLAEDVGLITAIDFWVLHEACYQLTQWQAQFPITLTMNVNLSAK
QFTKSDLPNQIEQILQEFNLDNSRLKIEITESILIEKTTLASQILRELSERNIQTCIDDFGTGYSSLSYLHRFPIHTLKIDRSFVARLNQNPEDGEIVKA
IIILGINLGLTVIAEGVETLDQLEFLRAHHCHAGQGYHLYQPLAADAIATLI--------
>tr|A0A011PXI2|A0A011PXI2_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-92 GN=gmr_9 PE=4 SV=1
----------------------------------------------------------------------REQSKLRQASSRLTHLLSASPTILYALRVD
GVWVSDN--ITRVMGYTPAECLAPD--W--AHLHGDD---RARVVGS-----------------------------------------------------
---RQR---TALESTRDGVMITGLDAGIITVNPAFCAMTGYAAADVIGKNPRFLQSGRHDRAFYQALWASLTQSGHWQG----RRADGEIYPQWATLSVV
KDEQGQACHYVGVFTDLTKLKRSEEQVERLAHYDPLTDLPNRLLLRSLLQHGLDRAQRQGGKSALLIINLDHFKNVNESLGHTLGDELLLAVAVRLQARL
RKEDTLGRLAADEFAAVIEGLHEESAEHTARDLLAALAAPFMLAGHEAYARASVGISLFPQDGTTANELLRTATAAMSRAKEGGGNQLASYTGELGQGAL
ERLEMETALRRVLSKGELLLHYQPKLDLASGVIIGAEALLRWQRPGVGMVPPDSFIPLAEKTGLIIPIGAWVIDEACRQIRAWSDAGLPVVKIAVNVSAR
QFASSELEGVLAAALSRHAVAPRMLTLELTESMLMAVPDQAIKRLERLREIGVGLSLDDFGTGYSSLAYLSRFPVDELKIDRSFVTNIVTDPNAANIATS
VIALAHRLHLKVVAEGVETEAQLGYLKKNRCDQMQGYLFSMPLPADAFSALL--------
>tr|A0A011P927|A0A011P927_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-93 GN=gmr_13 PE=4 SV=1
----------------------------------------------------------------------REQSSLRQTSSRLAHLLAASPTILYALRVD
GVWVSEN--ITRVMGYAPADCMAPD--W--AHLHADD---RDRVLGS-----------------------------------------------------
---RQR---TALESTRDGVMMISLGGEIITVNPAFCEITGYAAADVVGRNPRFLQSGRHDRAFYQAMWASLTQTGHWQG----RRADGEIYPQWATLSVV
NDEQGQASHYVGVFTDLTKLKRSEEQVERLAHYDPLTDLPNRLLLRSLLQHGLDRAQRQGGKSAVLIINLDQFKNVNESLGHTLGDELLLAVAARLKARL
RKEDTLGRLAADEFAAVIEGRQDENAESTVRALLAALATPFMLAGHEAYARASVGISVFPQDGTTANELLRTATAAMSRAKERGGNQYALYTDELGQGAL
ERLEMESALRRVLSNGELLLHYQPKLDLASGVIVGGEALLRWQRPGAGLVPPASFVPLAEKTGLIVPIGAWVIDEACRQIRAWSDAGLPVVKVAVNVSAR
QFSSPELESVLAAALSRHSVAPWMLTLELTESMLMAAPDQAIKRLERLREIGVGLSLDDFGTGYSSLAYLSRFPVDELKIDRSFVTNIVSDPKDANIATS
VIALAHRMHLKVVAEGVETEAQLGYLKKNGCDQMQGYLFSKPLPADDFATLL--------
>tr|C7RQ11|C7RQ11_ACCPU Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Accumulibacter phosphatis
----------------------------------------------------------------------QESSSVRPATTHRQLVLSAGPTVLYACGVD
GLWVSDN--ITRVLHFSPAECLAPD--W--SHVHDAD---RAHVLET-----------------------------------------------------
---RQR---TALESTRDGVLIADLTGRIISVNPAFSEMTGYTAAEAIGRNPRLLQSGRHDRAFYQAMWASLTQAGHWQG----RRADGEIYPQWATLSVV
KDEHGQPTHYLAVFTDLSKLKHREEELEHLAHYDPLTDLPNRLLLRSLLQHALERAQRQGGKSAVLVINLDQFKNVNDSLGHALGDELLLGVTARLKARL
RHEDVVGRLGADEFVAILEASQDENAGSIAGDLLAALAPPFVLAGHETYARASIGISVFPQDGKGANDLLRSADVAMHRAKQRGGNQYAFYTGELGHGAL
QRLEMETALRRALIQGELVLHYQPKLDLASGVIVGGEALLRWQRPGFGLVPPYRFIPLAEETGLIVPIGAWVINETCRQIRAWAEAGQPSVMVAVNVSAR
QFAGGELEAVLATALRKHAVDPRMLGLELTESMLMAAPEQATERLDALRRVGVAVALDDFGTGYSSLSYLSRFPVDELKIDRSFITHIVSDPKAANIATA
VIALAHRMALKVVAEGVETETQLSYLRKNRCDQIQGYLFSAPVPADEFATLV--------
>tr|A1KAZ1|A1KAZ1_AZOSB Uncharacterized protein OS=Azoarcus sp. (strain BH72) GN=azo3381 PE=4 SV=1
----------------------------------------------------------------------RERAALRTMTQRLEEVLDCSPSVNYTLTRG
ETWMSHN--LTRMTGFSVAEALAQG--W--RTVHPDD---LERASRA-----------------------------------------------------
---LLR---AVIESTHDGVVLTDLDGAIVAVNRAFTEVTGYSRDEVVGQNPRFLQSGRHDRGFYLSMWAALKEAGHWQG----RRKNGELFPEWLTLNAV
RNEVGHVTHYVGVFTDISKLKQTEDRLDYLAHHDPLTDLPNRLLVLSRLEHALDGAQRRGCRVAVMFLDLDRFKTVNDSLGHAAGDELLRAVAARLRGAL
REEDTLGRLGGDEFMVLLEHVEAADAAVVAKNLVEVLAAPFALSGHEVFIRASIGISFYPDDGDDFMTLVRNADAAMYRAKAQGRNTYGFYTEDLIRSAT
ERLALETRLRRALEHDEFVVYYQPVLGVKDGRLLGAEALVRWKPQGEPMVSPAAFIPVAEETGLIVALGEWVLRDACRQVREWIDAGYAFGQVAVNLSAE
QFRRQDVSAMLATVLAETGLPATQLELEITESSLLEAGEHAVGLLERLKQQGVGLAIDDFGTGYSSLAYLKRFSIDKLKIDRSFVQDIADDSNDLAIASA
IVAMARALDMAVQAEGVEGEAQLELLRGLGCGSYQGYLCSPPLPADEFEARF--------
>tr|I3YBB6|I3YBB6_THIV6 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiocystis violascens (strain ATCC 17096 / DSM 198 / 
----------------------------------------------------------------------RERANLRETARRLELALASSPVILYTRRLD
DTWVSEN--IFRLLGYTAEQMLQPG--W--AHLHPDD---REDALAC-----------------------------------------------------
---RLR---TVFESTREGVIITDLNSRILSVNRAYTDITGYSEDEVRGRKPSLMQSGRQDPSFYQTLWANIAANGHWQG----RRKNGELYPQLLSISAV
YDSQGQPSHYVGVMTDISQLKESEARLEHLVHYDPLTNLPNRRLVQSRLQHALEHAERYRHRIAVLFLDLDRFKNVNDSLGHPVGDELLEALTRRLSQRL
REDDTLGRLGGDEFLILLENLEREDAGGVAQTLLQLLETPFRLPGPELYVGASIGISLYPDDGDSVTELIKHADVALYQAKEQGRNTYRFYTPKLTAAAN
ERLALEARLHRALANDEFVLHYQPQFETDSGALIGCEALVRWHSPEEGMISPARFIPLTEETGLIVPLGEWVLRSACTQGRRWMDAGHPEVTIAVNLSGR
QFQQHDLARRVAAILDETGLPADRLKLELTESMIMGHGEQVVELLHALKTLGSRLSIDDFGTGYSSLAYLKRFPIDELKIDQGFVRDIPQDENDMEIAAT
IIAMARNLNLKVIAEGVETRAQLDFLTRQGCHACQGYLFGRPMPADEFARTF--------
>tr|D3RML4|D3RML4_ALLVD Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Allochromatium vinosum (s
----------------------------------------------------------------------RERANLRAASERLALALATSPVILYSRRLG
PTWISEN--IARLLGYSPTLALQPG--W--SRLHPED---REAALDW-----------------------------------------------------
---RLR---TVFESTREGVIITDLEGRILDVNRAFTEISGYSEPEVLGRNPSLLRSNRQDHAFYQAMWHSLKTTGHWQG----RRKSGELYPQILTINTV
ADSQGRPSHYVGVMTDISQLKQSEARLEHLVHYDPLTNLPNRRLVQSRLEHALERADRQGGRVAVLFVDLDRFKTVNDSLGHPSGDVLLELLARRLSERV
REDDTLARLGGDEFLVLLENLQREDAAAVAESLLSLLQQPFHLPGQELYVGASIGISLYPDDGHTVTDLIQHADVAMYQAKEEGRNTYRFYTPSLTQTAR
ERLGLEARLHRALASEEFVLHYQAQIDMRDGRLIGCEALVRWHSATEGLVAPDRFIPLAEETGLIVPLGEWVLRQACADCQSWRARGLTDLTVAVNLSGR
QLRSPDLVERVTRVLRETGLPAERLKLELTESMIMDQREQALERLRALKALGVRLSIDDFGTGYSSLAYLKRLPIDELKIDRDFVRDIPEDSSDMEIAAT
IIAMARNLRLNVIAEGVETPEQCDFLIRQGCTAGQGYLFGRPLPAEAFAQVM--------
>tr|H0PYF2|H0PYF2_9RHOO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Azoarcus sp. KH32C GN=AZKH_0032 PE=4 SV=1
----------------------------------------------------------------------HERALLRDTSAHLSHLLAASPVILYTLRMC
DTWVSDN--IERIFGTTPAEAMIPG--W--DHLHPDD---RAAALAV-----------------------------------------------------
---ALR---AVFETTRDGVMITDLERRIVSVNRAWCEMTGYSADDALGKVPQLFKAGLQNAAFYRRMWAQIARSGYWQG----RRRNGEQYPQWLSVSTV
HDAEGTPTHYVGVMTDVSKLRRSEAELERLAHFDPLTDLPNRLLVESRLEHAIEQAARLGSGIGVLFVDLDRFKTVNDSLGHTIGDEVIKSIAHRLREGL
RGDDTLARWGGDEFLVIIENTAKDEAASLAQGLIDRMQQPFQLSGQLIYVGASIGVSLYPQDARTAAALIQHADTALNQAKAQGRNTYRFFTDAMTLEAQ
HHLDLERRLRRALEQQAFVVHYQPQIDLASGRLTGCEALLRWHDPQEGLIPPGNFIPFAEETGLIVPIGEWALETACAQARRWLDAGLPALNLAVNLSAR
QLWQTNLPERIAEILARTGLPPGSLELELTESMIMGHEPEAVERLGQLRRLGLKLAIDDFGTGYSSLSYLKNLPIEVLKIDQSFVRGIPQDRKDMEIAAG
IIALARKLNLRVLAEGVETAEQLAFLREQGCDSYQGYLFSRPLPAEEFEKLL--------
>tr|S6ABT1|S6ABT1_9PROT PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Sulfuricella denitrificans skB26 GN=SCD_n01149 PE=4 S
----------------------------------------------------------------------RERSALREVSERLGRALTTSPVILYTLRLD
PVWVSSN--IERLLGYTEAQALQPG--W--SRLHPDD---RDAALAR-----------------------------------------------------
---ALR---AVLESVGEGVMVTDLQSLIVSVNSAFTTITGYTEAEVLGRNPGLLRSGREDQAFYRAMWSSIKDTGAWQG----RRKNGELFAQLLIISTV
YDSDGLPGNYVGVMTDLSQLKDSEARFEHLVHYDPLTALPNRQLLQSRLQHALATAELHKQRLAVLYIDLDRFKNINDSLGHPVGDELLEALARRMGEQL
RGEGILGRLGGDEFLLIMEDLQREEAAGVAKDLIGLLDQPFHLPGHEVFIGASIGISLFPEDGASCTKLVQHADVAVYQAKESGRNTYAFYTPSLTVIAN
EKLDLEARLRHALTQGEFLLHYQPQLDIQSGGLIGCEALVRWNNPQQGLISPARFIPLAEETGLIVPLGEWVLRQACSQARAWLDAGMPNLSMAVNLSAR
QLQQPDIVARVAAILEETGLPAETLKLELTESMIMGHGEEVVVLLQDLKALGIRLSIDDFGTGYSSLAYLKRFPIDEIKIDQGFVHDIPNDSNDNQIAIA
IIGMAHGLSLKVMAEGVETEAQRDFLAQHGCDAFQGYLFSRPLPAEEFTRFL--------
>tr|N6YLJ7|N6YLJ7_9RHOO Response regulator receiver modulated diguanylate cyclase/phosphodiesterase OS=Thauera sp. 27 GN=B447_00485 PE=4 SV=1
----------------------------------------------------------------------RERETLRATSDRLSRLIDASPTILYSLSLD
ATWVSEN--ITRHLGYTVSEALQPG--W--SKLHADD---RAAAIAR-----------------------------------------------------
---ALK---AVFSATRDGVFITDLQPRIVAVNRAFSEITGYAETEALGRNPSMLQSGRHERSFFQSLWKTLGETGHWHG----RRKSGEIYPQWLSISTV
KDDKGEPHRYVGVFTDIGELKSFEARLEHLAHHDPLTELPNRLLMQSRLQNAIDRAERHGNKVAVLYLDLDRFKTVNDSLGHPVGDELLVQLTQRLSSRL
RDEDTLARLGGDEFLLLVESVTQGHAVAVAQSLIELLHTPFALPGHEVFIGLSIGISLYPDDALTATELVQHADAAMYLAKQQGRNTYRFHTHALTRAAA
ERLSLETRLRHGLDRGEFLLHYQPLVDATTGKALGVEALVRWQPPGEDLVPPGRFIPLTEETGLIVRLGAFVLRAACVQAQAWREQGLALGTVAVNLSAR
QFMDDGLVEEVKTALAISGLPPHCLELELTESLLMEQAPRTIATLSALKQLGLRLAIDDFGTGYSSLAYIKRFSIDKLKIDQSFVRSLERSADDKAIVAT
IVAMARTLRLEVLAEGVETDAQASILASLGCVEHQGYLYARPLPPAELETWL--------
>tr|Q82U13|Q82U13_NITEU Uncharacterized protein OS=Nitrosomonas europaea (strain ATCC 19718 / NBRC 14298) GN=NE1700 PE=4 SV=1
----------------------------------------------------------------------RERINLKQTNLRLSHLLAASPMVLYNLRFT
GVWVSEN--IERLIGYTPGEALAPG--W--SHLYPDD---REQVLER-----------------------------------------------------
---ALR---TVFESIREGIVVTDLEPRIVAVNRAYTEITGYSAAQVVGKNPKIIRSGRHDKSFYQAMWSSLQEEGYWSG----RRKNGEIYPQWLTISAV
SNGRKELCNYVGVFTDISQIKQSEAQLAHLAHYDPLTGLPNRLLVQSRLHHAVERAQRYNLRVATLYIDLDRFKNVNDSLGHPIGDELLIKLTERLKNRL
REEDALARLGGDEFLLVMEDVKDSESAIVAQTLIDLLATPFVLPGHEIFINASIGISLFPDDASNATELIQHADMAMYQAKKEGRNTYRYHTEALSIAAN
ERLIMENRLRHALAAGEFILHYQPLIDARAGHVIGVEALARWQPPDNTIVPPGKFIPIAEETGLIVPLGEWVLRTACEQGRAWIDTGLPPLVMAVNLSVR
QFQSENLVELVQRILEETRLPAVCLELELTESMFMEHAERSIETLNRLKALGIQLAIDDFGTGYSSLTYLKRFPIDKLKIDQSFVRGLAHDPNDREIAAT
IIAMARGLKLGVLAEGIESEQQLDFLRQQGCDYYQGFLFHRPVPAIELEAWL--------
>tr|W9VEM8|W9VEM8_9GAMM Putative signaling protein OS=Thiorhodococcus sp. AK35 GN=D779_1400 PE=4 SV=1
----------------------------------------------------------------------REQANLRSALQRLDMVLAASPAVLYTRRLD
LTWMSEN--VSR-LGCDTAAAMAAD--W--SHLHPED---RQAVQER-----------------------------------------------------
---KLR---AVFESAHEGVIVTDLDSNIIRVNPAYTQITGYSAEEVRDQTPRILQSGHQDITFYRTLWTSLKTVGHWQG----RRKNGELYPQLLSISTV
YDPQGAPSHYVGVMTDISQLKQSEARLEHLVHFDPLTNLPNRRLLLSRVQHAIEQAGRKRKRVALLFIDLDRFKHVNDSLGHPVGDELLVALTERLRTRL
REEDTLGRLGGDEFLVLLENLDREDAGKVARILLELLEEPFWLPGPTLFIGASIGISLFPDDGDSVTELVKHADVAMYQAKEHGRNTYSFYTPTLTIAAN
ERLELDARLRRALTNDEFVLHYQPQFDSMTGMLIGCEALLRWHSPEDGLVPPDRFIPLAEETGLIVPLGDWVLQTACAQHKRWLDSGLPDMVVAVNLSAR
QLQQHDLAERVAAILDNTGLPADRLKLELTESMIMLEGDRAIERLLALKALGLKLSIDDFGTGYSSLAYLKRFPIDELKIDRGFVRDIPHDRNDMEIAAT
IIAMARNLNLRVMAEGVETHQQMEFLTRQGCHGCQGYLLGHPLTAEEFLEQL--------
>tr|Q5P4F9|Q5P4F9_AROAE Azoarcus aromaticum EbN1 complete genome OS=Aromatoleum aromaticum (strain EbN1) GN=ebA2985 PE=4 SV=1
----------------------------------------------------------------------RERAELRATTAHLTHLLSASPTVLYTLQIR
DSWVSDN--IVSILGVSSADALSPG--W--AHVHPDE---RAAWIAT-----------------------------------------------------
---ALR---AVIESTRDGVMVTDLSQRIVSVNRAWCEITGFSEEEALGKTPSMLKSGLQDDAFYRQLWDSVAHTGHWQG----RRKNGELYPQWLSVSTV
YDEDHKPVRYVGVMTDISQLKQSQAQLERLAHYDPLTNLPNRLLVQSRLEHAIEQASRQQLGLGVLFIDLDRFKNINDSLGHATGDELLVAISWRLRTRL
RPEDTLARWGGDEFLVIIDNLRKDESASVAQNLIDLMGEPFSLPGEVVYVGASVGISLYPQDGTSAAELIQHADAALNQAKAQGRNTFRFFTEALSQAAQ
RHVDLERRLRVALEQQAFVVHYQPQIDITTGRVTGCEALVRWQATDEGAVSPNRFIPFAEESGLIVPLGEWVLETACRQARTWRDAGLAPLRVGVNLSAR
QLWQAELPDRIAAILQRTGLPPECLELELTESMIMGHEAQAEQRLGLLKSMGLGLAIDDFGTGYSSLAYLKNFPIEMLKIDQGFVRHIPDDRKDMEITAG
IIALARKLNIKVLAEGVETDAQLAFLTEQGCDAYQGYLFSRPLPAEDFAKLL--------
>tr|G2E434|G2E434_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii A
----------------------------------------------------------------------RERANLRAAAHRLDMALAASPIVLYTRQLN
RTWVSDN--VQR-FGYEAEQLLDQD--W--THLHPDD---RDSAHAA-----------------------------------------------------
---KLR---TVFESTREGVIITDLDSHIIAVNPAYTDITGYTAEEVRGQTPRILRSGRQDDAFYQTLWANITSGGHWQG----RRKSGEIYPQLLSISAV
YDPQGTPTHYVGVMTDISQIKRSEERLEHLVHFDPLTNLPNRRLVLSRLHHAIEQTERSRRRVAVLFLDLDRFKNVNDSLGHPVGDELLQALTQRLRERL
REEDTLGRLGGDEFLVLLENLEREDAGRVARALLQLLQEPFELPGPVLYIGASIGISIFPDDGNSVTELVKHADVAMYQAKEQGRNTYRFYTSTLTIAAN
ERLELDARLRRALINEEFILHYQPQFDSLTGMLIGCEALVRWHSPEHGLIAPDRFIPLAEETGLIVQLGDWVLQTACAQHKLWLDNGLPDIMIAVNLSAR
QLQQQDFAERVAAILDATGLPAERLTLELTESMIMLPGEQAIELLRELKALGLKLSIDDFGTGYSSLAYLKRLPIDELKIDQGFVRDIPQDRNDMEIAAT
IIAMARNLNLKVIAEGVETDQQMEFLTLQGCHGYQGYLLGHPLTPEAFIEQL--------
>tr|F9ZVU6|F9ZVU6_METMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomonas methanica (s
----------------------------------------------------------------------RERVVLKQTAKRLSRVLAASPTILYNLRFF
KTWVSDN--ILRQLGYTPEQAMQPG--W--DHIHPDD---QVDVAEN-----------------------------------------------------
---ILR---AVFDSTREGILITDLKPRIVAVNRAYTDITGYSETDALGKNPSCLKSGRHDKVFFQELWTKLSGTGHWQG----RRKNGEFYPQWLTINTV
YNESGSPCRYVGVFSDISQIKESEARLERLAHFDPLTNLPNRLLAQSRLRHAVEHAGRHGHRVAVLYLDLDRFKTVNDSLGHPSGDELLSLLAGRLSKRL
RDEDTLARLGGDEFLLVLECIEAEVAATVAQSLIDLLLPPFDLSGQEIYLGVSIGISLYPDDAGDVTELIQHADMAMYLAKQEGRNTYRFHTPALSRAAS
ERLSLETCLRRALTEHEFVLHYQMLIDARTEAVIGVEALVRWQPAGKALVPPGIFIPIAEETGLIVPLGEWVLSTACKQGKAWMDAGIPALIMAVNLSVR
QFQSVDVVELVRRVLADSGFPADRLELELTEGMLMDDAKQSIATLNALKELGVRLSIDDFGTGYSSLAYLKRFPIDKLKIDQSFVRGLSDDINDREITAT
IIAMSRVLKLDVLAEGVETEQQLAFLRESGCDYYQGYWFHKPEPAADLQKRL--------
>tr|F9ZG63|F9ZG63_9PROT Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Nitrosomonas sp. AL212 GN
----------------------------------------------------------------------RERISLKKTSLRLSDLLAASPTILYNLRVV
GVWVSEN--IERLLGYTQEEVMAEG--W--LHVHPDD---REAALTH-----------------------------------------------------
---SLK---AVFESTREGVVITDLQPRIVAINRAYAEITGYSEEQVLGKNPRIIKSGRHDKLFYQAMWASLTKAGYWRG----RRRSGDIYPQWLTISTV
FNDRNEPCNYVGVFTDITQIKQSEARLAHLAHYDALTGLPNRLLVQSRLHHAIERTLRHGNQIAALYLDLDRFKNVNDSLGHPIGDELLVMLALRLKKRL
REEDTLARLGGDEFLVVLEDIKDNEPAMVAQTLIDLLATPFSLPGHEIFINTSIGISLFPTDANSVTELIQHADMAMYLAKQEGRNTYRYHTDALSIAAN
ERLVLETQLRQALSAGEFVLHYQPLIDARKGQVMGVEALVRWQPPDKAMVSPGKFIPIAEETGLIVPLGEWVLRTACAQGRAWMDADFPPLVMAVNLSVR
QFQSENLVELIRQVLEETKLPAACLELELTESMFMEHAEQSIEILKTLKSLGVRLSIDDFGTGYSSLTYLKRFPIDKLKIDQSFVHGLAYDPNDREIAAT
IIAMARNLKLDVLAEGVESEQQLDILNQHGCDYYQGYLFHRPVPAQELEVWF--------
>tr|W0E1A8|W0E1A8_MARPU Diguanylate cyclase OS=Marichromatium purpuratum 984 GN=MARPU_02665 PE=4 SV=1
----------------------------------------------------------------------RERAALRQTSTHLGLMLEASPVVLYTLRIE
QTWVSDN--ITALLGFTRDETMRPD--W--RQIHHDD---RESVERA-----------------------------------------------------
---ALR---AVLASAREGVVVTDLRPRILSINPAYTQITGYSAEEVIGRNPNLLRSERQGRAFYQQLWACLLEQGHWQG----RIKSGEVRPVLLSISLV
TDTAGNPERYVGVMTDLSQLRHSEAARERLAHFDPLTGLPNRLLLQSRLSHALERAQRHGHYIAVLLIDLDRFKHINNSLGHPAGDNLLELLAHRFATRL
REGDTLGRLGGDEFLVVLERLHQRQAAGVARDLLELLRRPITLPDHEIHVGASIGIGVYPQDGSSASELIQHAEVALYQVKAQGRGNYGFHTPELSAQAA
ERLELEARLRQALGNEEFLLHFQPQFDCVSGALIGCEALVRWNTPDQGLVPPTRFIPLAEETGLILPLGDWVLRTACRQGMCWLDAGLVLETIAVNLSAR
QLLQPDCVDCIEQALTATGWPAHRLKLELTESMLMGEGDEVEQRLQALRALGIRLSIDDFGTGYSSLAYLRRFAIDELKIDRSFVRDIPAQRDDMEIAAT
IIAMARNLKLRVIAEGVETEAQLEFLRERGCEAYQGYLCAPPLTPEAFAARF--------
>tr|F5R8E3|F5R8E3_METUF Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Methyloversatilis universali
----------------------------------------------------------------------REEQRLRDMNRRMSWLMASSPTIVYNLRTH
GFWVSEN--ASRILGYPMEDICREG--W--THLHPQD---RDAVLAR-----------------------------------------------------
---ELR---AVFESTRDGVFITDLDARIVALNRAFTEISGYPQEEALGQNPRILQSGRHDAAFYQSMWESVLESGYWQG----RRKNGELYQQLLTISTV
RNEAGRASRYVGVMTDISQLKRSEAQLDYLAHHDPLTDLPNRLLLQSRVQHAIERAERQRDHFALLFIDLDHFKNVNDSLGHPVGDELLTEIAHRLRTRL
READTLARLGGDEFVLLLENIQMEDAAQVAQSLLDLLHKPFRVSERDIYIGASIGIAVYPDDGRTVTELVQHSDVAMYQAKEAGRGAFRFYTEAMSRAAQ
DRLHLDTRLRRALERGEFALHYQPQIDMASGRIIGAEALIRWLDPEEGMVSPARFIPVAEESGLIVPIGEWVLRTACAQAQAWQAAGH-ELSIAVNLSAR
QLQHADMAIRLAELFREFGLGPGRLELELTESMLAGDHAQTEARLQALKALGVELSIDDFGTGYSSLAYLKRFPIDVLKIDQSFVRDIPQDRNDMEIAAT
IIAMAHTLKLRVIAEGVETPEQHAFLKERGCDAWQGYLRSRPVPADEFEQRF--------
>tr|A0A011QKB9|A0A011QKB9_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-92 GN=gmr_13 PE=4 SV=1
----------------------------------------------------------------------QRTAALLAMTSQLQATLNAIPDLLFEFDLN
GRYMNIHAPHPEALGAPKETL-L-----IPDVLPPKAA----KVCMA-------------------SRK-----------DARFIFL----SRDITDRKQ
AEAQLRKLS--VEQSPESIIITNLQAEIEYVNEAFVQKTGFSRDEAIGENPRMLQSGRTPPQTYASLWGALKQGLPWKG----KRKDGSEFLEQCIIAPI
RQADGSTSHYVAIKEDITEKRAAEERINTLAFYDSLTGLPNRRLLLDRVQQSLAADTRSPHGSALLFIDLDHFKSLNDTLGHAEGDELLKQVSARLLTCI
RGCDTAARLGGDEFVVLLPDLAKEITRLAGERILSELRQSYSLANGQHHVTASIGVALFGGAASDSSDPVIRADQAMSQAKTAGRDTLCFFDPEVQAAAD
AQTALETELGQGLEAGQFLLHYQPQISLRTGEITGLEALIRWQHPDGKLVPPNDFIPAAERIRLILPVGKWVIEEACRQIRAWGEAGLPPVKVAVNVSAH
QFLNGDLDVIVSQALKRHDVAPHLLDVEMTESVLMHDPVAAGIMLERIKATGVALSLDDFGTGYSSLAYLSRFPFNQLKIDRSFVQKMVTDPGAATIVRM
IIDLAHRMRLNVIAEGVETEAQLGFLQKQDCDQMQGYLFSRPVPAQEISALL--------
>tr|W9VYF0|W9VYF0_9GAMM Diguanylate cyclase OS=Thiorhodococcus sp. AK35 GN=D779_1374 PE=4 SV=1
----------------------------------------------------------------------TAQKALRASERQLMDIIDFLPDPTFAVDRD
GRVIAWNFGLERLTGCSKSQLLGQPIEHFYDTPHPLL---LESILDPAWRQGCEVE--GRARTIDG-IRAYRYNGVPVRD-QGRLIGIAGVGQDISEQLR
DQEDLR---TVLKNTREGVLISDSDTRIVAINPAFTEITGYSETEAIGGSTRMLKSGRHETAFYQAMWALIASSGHWQG----RRKSGEIFPAWLTISTV
RDDAGEITNYVGVLSDISQVKRSEAQLEHLAHYDPLTDLPNRLLLNSRLEHAIQRARRKHTKVAVLFIDLDRFKHVNDSLGHPVGDALLQAVAQRLAGRT
RGEDTLARLGGDEFVILLESIDQREAGRVAQLIIDLMRQPFNLAEREIYVGASIGISIFPDNGEGVTELLRNADTAMYQSKAQGRNTYRYYTESLTRAAN
ARLLLESKLRRALEREEFILHFQPQVAMADERILGVETLVRWQDPEEGLIPPDSFIPLAEETGLIIPLGAWVLRQACRQMRDWRAAGMPTMTLAVNLSIQ
QFAQRDLAVQVGAILDEYDLPASCLELELTESMIMHNDAHGIDILNAMRELGVGLAIDDFGTGYSSLGYLKRLPIDRLKIDKSFVQGIPEDRNDAEIAAT
IIAMAHNLKLQVLAEGVETQEQHAFLREAGCEAYQGYLFSPPVPAEKIEALL--------
>tr|D3SFG5|D3SFG5_THISK Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thioalkalivibrio sp. (str
----------------------------------------------------------------------RERAALAASERRYREVIDQAGNVFFHLDQQ
GRWVFANPAWSEITGFVLEQTLGRP--L--DFVVAED---RGRVGELAMVTGDRTY-SERETLEQHRFFWVNPEGEPPGADEHMARIVAANLGAALERRR
ALTGLR---AVFQSTRDGILITDLSARIVAVNPAFTEISGFSEHDALGRNPRFLKSGRHDAEFYREMWATLGATGHWQG----RRYTGETHPQWLSLDVV
RDEGGEPQYYAGVLTDLSALKRSQNELEYLAQHDSLTDLPNRSQLQTLLGRALERARAERRGLAVLCLDLDRFKTLNDSLGHSVGDRVLLEVARRLADVL
ESPDLLGRLGGDEFLAVLESADTELAEERARALLEVLQRPFVLDGQVVYVNASIGVSRFPADGDTVVDLIQHADAAMYHAKALGRETWSFYTEDLTQAAA
ERLDLENRLRHALNNDELAVHFQPQVRLVDGRFTGVEALVRWRTGSGESIRPDRFIPIAEETGLVVPLGEWVLREACRQGRELLDQVSPDLVMSVNLSPV
QLRRGNLVEQVRAILGETGFPARQLEFEITETGLMQQGDQAVTRLKALKSLGVRVAIDDFGTGYSSLAVLQTFPLDVLKIDRSFVDGVDEEGTDRLIAST
IIAMARNLQLEVIAEGVENEAQARFLIEHGCEFGQGYLYSPALPPEQLLEWA--------
>tr|W0DXK6|W0DXK6_MARPU Diguanylate cyclase OS=Marichromatium purpuratum 984 GN=MARPU_04150 PE=4 SV=1
----------------------------------------------------------------------RAQEALCASERRMTDIINFLPDATFAVDTQ
GRVIVWNLAVERMTGIPREQIIGQGEAYFYGERRALL---VDLILAPALTQGCEIE--GRARTING-IRNYRYNGVPVRD-HGEVIGIAGVGQDITERLR
DQERLR---AVLDNTHEGIMVSNAQDRLVAVNQAFTEISGYGEDEALGRAPNLLKSGRHGRQFYQAMWASILQTGHWQG----RRRNGEVFPAWLTISRV
RDERGDTSNYVGIFSDISQVKQSEARLEHLAHYDALTDLPNRLLLLSRLEHAIHRAKRERSKVAVLFIDLDRFKNVNDSLGHPVGDELLQAVAARLRVRI
RSEDTLARLGGDEFVLLLESIERDEAGNLAQQLIDLMAEPFGLTGREIYLGASIGISLYPDNGTDTTQLLRNADTVMYQAKAQGRNTYRYYTESLTRAAN
ARLSLESRLRRALEREELVLHYQPQVDMRTTRLTGIEALVRWEDPAEGLIPPDRFIPLAEETGLIIPLGAWVLASACRQLQDWIDGGAPPLTLAVNISSH
QFAQPDLALHVDRELTASGLSPERLELELTESTIMQHNRRGMEILEALRALGIALSIDDFGTGYSSLAYLKRLPIDKLKIDKSFVQGIPEDRNDAEIAAT
IIAMARNLNLRVLAEGVETEAQRDFLHQAGCDAYQGYLFSRPLPAAEFARQY--------
>tr|G2DWJ5|G2DWJ5_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii A
----------------------------------------------------------------------QAQRALRESERRLMDIIDFLPDPTFAVDRE
GHLIAWNHALERITGRDKSRVLGQHIKQFYDTPHPTL---LDAVLNPALNKGGEVE--SLALTTNG-LRTYRYNGVPVRD-SGTIIGVAGVGQDITASVR
NHEELR---TVLKNIREGLMISDAQNKVIAINPAFTEITGYTQAEALQGTTRMLRSGRHDPAFYQAMWASIKRSGHWQG----RRKNGEIFPAWLTISTV
RDESGEISNYVAVLSDISKIKQSEAQLEHLAHYDPLTNLPNRLLLNSRLEHAIQRARRNNTKVAVLFIDLDRFKHVNDSLGHPVGDELLQAVARRLSGRI
RSEDTLARLGGDEFVVLLESIAKGECGLVAQMIISLMQPPFRLSEREIFIGASVGISIYPDNGAHAIDLLRNADTAMSQAKIQGRNTYRFYMESLTRAAN
ARLTLESKLRHALDSEEFLVHFQPQVSMSNERILGVEALVRWQDPEEGLIQPDRFIPLAEETRLIVPLGAWVLRQSCRQMRIWRDAGLPPMTIAVNLSIQ
QFAQRDLAVQVADILEAFDLPASCLELELTESMIMQNDAHGIDILNELQELGVGLAIDDFGTGYSSLAYLKRLPIDTLKIDKSFVDGIPNDRNDAEIATT
IIAMAHNLKLSVLAEGVETPEQRIFLRDSGCDSYQGYLFSRPVPAESIEALF--------
>tr|V5V3U7|V5V3U7_9CHRO Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Thermosynechococcus sp. NK55a GN=NK55_046
----------------------------------------------------------------------QVEAALRASEERFRLATLHLPGAIFRPDGR
NCALYLNPMCE--WGVPAEAAAADGELW--VH--PEDREAWQSVLRS---------IDFRLRHCNGTYRWFHSEAVLI--EQGQPCKVVGTNIDITERKA
IELALQESEFLAENTSDILGLYDPQWQCLYVSPSCQTLLGIPPEKLLGQHF-V---NQE----LE----------QMIQTYEVCTAQGDPLWLE------
-TSQGQLHQLQTTSRDVTARVKVQLQLHRQAYHDSLTGLPNRLYFMEQLEAAITEAQTS-PYYAVLFFDLDRFKVINDSLGHGVGDQLLMTFASWLRCLV
ENRYTVARLGGDEFAILLTEVPHQRAIALCEQIIHRLQEPLRVEERQIFLSTSIGVVFCQNEYETGIAVLRDADIAMYAAKRQLTKRYAVFNAQMHKQVL
ERLHFEHDLRHALNGGELQVFYQPVFHLKSQRLVGMEALVRWQHPERGLVSPAHFIPIAEETGLIVALDQWVLEQTCRQLWTWQQQYGIALRLGVNVSAK
TLQDATFLKYLDTLQRRYPLPRQHLLLELTERISIELGSEMLNLLELLRNRNIEIGIDDFGTGYSCLSYLQSLPIQHLKVDRSFVSQLEENERNLQITRM
ILLLSQQLGYRAVAEGIETPRQLQILQELGCDYGQGYLFGPPLPAEEFESLL--------
>tr|B8HRL5|B8HRL5_CYAP4 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Cyanothece sp. (strain PCC 7425 / ATCC 29141) GN=Cyan74
----------------------------------------------------------------------QAEAALRESESRFQNIAANIPGIIYGADGS
DQFTYISSGFC--YGFEPDEALQDSSIW--TH--PDDLERKQSVIES---------------------------------------------IDISDRKQ
VEVALQESELLAENMNDLVCLHDLEGHYLYVSPSCETLLGYRQDEMLGQVP-I---YQE----AF----------IPALTYRMRQKSGNYIWFE------
-TQTGQIVQLQTTSRDVTERIQVQEQLKYDALHDALTGLPNRLLLMERLELAIHRAQRL-PHFAVLFLDLDRFKIINDSLGHLAGDQLLTAVAEKLCSTL
RDIDLVARLGGDEFVILLEEVKDQEIIKFVDEIFAGLQIPILIAGCEVYITASIGIVFSDDKPAQASHLLRNADIAMYRAKAKGKDRYEIFNMEMHAQAL
NRLHLENDLRRAVERQELILHYQPILALDTGHIVGFETLVRWKHPIQGLKFPADFIAMAEETGLITHIDIWAISMACHQLAKWQAAFPGTMKVSVNLSAH
DLRRSNLLEDIDNVLAQANIDGCCLCLEITESMLIEDIESTIKLLNQLKERGVQILIDDFGTGYSSLSYLHRLPVDSLKVDRSFVNQIQVDNRNAKIVET
IASLSVSLGLDAIAEGIETPKQLKRLQKLGYKFGQGYLFSQPLTHKEVEILL--------
>tr|Q31P31|Q31P31_SYNE7 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Synechococcus elongatus (strain PCC 7942) GN=Synpcc7942
----------------------------------------------------------------------KAELALQESQTRFQRIADNLPGIIYGQDGT
DQFTYISSGFR--YGIDPETALENSNVW--IH--PEDIEYKTSIIKS---------------------------------------------IDISDRKK
IEAELQTSELLAENMNDLVCLHQADGTYLYVSPSAEALLGFSSEEMVGQNP-I---RDE----AH----------QAVLVYRMRKKLGGYIWFE------
-TDQGVVIGLQTTSRDVTQRIEIQNQLQYDACHDSLTGLANRNLLIERLELSLKRSKRL-QKYAVLFLDLDRFKVINDSLGHITGDQLLVSIAQKLQSII
RSHDLAARLGGDEFVVLVEDIQTDEPIKVAERILAAIQVPLELEERSIYTSTSIGIVFGSHEYESATQLLRDADTAMYRAKSRGRARYEVFDSAMHSQAL
ARLHLENDLRQAIARQEFVLYYQPIIQLQTGKITGFEALIRWQHPTEGIKLPIDLIPIAEETGLITSIDYWVLNQACRQLSEWQASYSQALSMSVNLSAQ
NLQHDHLMDEIQSVLQATKIKPGSLTLEITESMLIENTDQTIQLLAAINEQGIEISIDDFGTGYSSLSYLHKLPVNNLKVDGSFVRKITTESTNYQIVNT
IIALNNQLGLKAIAEGIETHEQLDLLSQLGYQYGQGYLFARPLNAKDVEQLF--------
>tr|D8FUM3|D8FUM3_9CYAN PAS fold family (Modular protein) OS=[Oscillatoria] sp. PCC 6506 GN=OSCI_530001 PE=4 SV=1
----------------------------------------------------------------------VTERALQESEYRYYTLAKMLPVGIFRTETA
GECLYVNPRFCEM-------------------------------------------LEYR-FQKGSEVTWVYCQAVPE--KNGEVTGYLGTLTDITDRKQ
AEESLKRAESIFENAIEGIFQSTPEGRYLSANPALSKIYGYNSPEELIEQIDV---YVNPRRAEF--VR------EVETESEVYCADGSTIWISENARTV
RNNNGELLYYEGTVEDITVRKMAEEKLLHDALHDTLTGLPNRALFMDRLGHAIELGK---PLFAVLFIDLDRFKVVNDSLGHLVGDQLLIAIAQRLKICL
RTGDTVARLGGDEFAILLENIKDSDATIIAERVQNELAAPFHLSAHKIFSSASIGIVCSGLLYDRPEDLLRDADAAMYHAKAQGKARHEIFDMSMHTRAV
ALLELENDLRRAVERQEFQLYYQPIVSLVNGKISGFEVLLRWQHPQRGLVTPAEFIRVAEETRLIVPIGWWMLRSACHQMYQWQQEFPTPLTISVNLSNQ
QFTQPDLIDQIRKILLETDLNPRSLKLEITESVIMDNAESAAALLLQLRALEIQLYIDDFGTGYSSLSRLHSFPTDALKIDRAFVSRMADDEGNEAIVQT
ILILAGHLGMDVIAEGVETAEQLAQLRALQCEYGQGYFFSKPIDCNAATVLV--------
>tr|Q60A83|Q60A83_METCA Sensory box protein OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN=MCA0985 PE=4 SV=1
----------------------------------------------------------------------RMEE----TLQQRSWATEGEAFFSAIAHHL
GRILGVDYVVIDRLA--RDAELA-----ALYARGEDLPN-I---CYR--------------------PLWDSA-GTAI-MEPESVTALLQLVAAALERDR
SERQLKARESLVEHSPDTVARYDRDCRRIYANPRLVEEAGVPLSELLGKTPVEF-PGGESSAYQAKIRQVETGEPAEF-----KTAQERELISHIRLTPE
FGFDGEVMHALAIGRDITEIDAYRRRIHHLAFFDSLTGLPNREMLNKRIREVMDGNPRPGRQFALMMLDLDRFKEINDTLGHGIGDLLLGRAARRLLGAV
GKDDTVARLGGDEFAVLVPAPAAQELTALAGRILDAFARPFLIEGRELFVSVSLGIALYPRDCTGIDTLFRYADTAMYHAKRQGRNNFQFYSAELTARAA
ERMRIESALRRALGRNELELHFQSQIDMVSGTIVGAEALLRWNRPGRGIILPRKFIPIAEETGLIVGIGDWILAQACQAVVAWNRHREQPLRVAVNLSTR
QFILNDLAGTVQRILDETGCRPEWLELEITESLLLEDSRGVRATLDAFDRMGLSIAIDDFGTGYSALSYLHRFPVKRIKIDRCFVHGIPSDRCKSELVKA
IISIAQALGLEVLAEGVETPRQAVYLQAHGCRLGQGYLFGEPQPLVGFEASI--------
>tr|K9VC28|K9VC28_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Oscillatoria nigro-viridis PCC 7112 GN=Osc7112_0917 PE=4 SV=1
----------------------------------------------------------------------LAELEI---ETLLQATIESTADGILAVDSA
GKVVSFNRKFAEMWQLPDLQVDSRD--NGFGINQLKYPE-I---FLN---------------FERYSL-----------IGR--VFS----FRDVTKRVQ
SEEKLRKSELLTRATNDAVWDFDLLKNEYWLSEEFEKVFGYKLNETQTIELESWWLNIHP-EERERVMLSNSDAECWSE----HRADGGYVFVLDRGYII
RNESGKAVRAIGTMMDITQRKQAEEIIRYQAVYDQLTGLPNRILFNERLLASLKQAQKNQKMLAVMFLDLDRFKKINDTLGHAAGDRLLEGFAARISDTL
RSTDTVARWGGDEFTILLPDINCEDAVKTAQRILNNLKPAFKLEGQPFHVSSSIGIALYPDDGEDAENLVKNADTALYRAKEMGRNNYQLYTSTINPQGS
RLLTIEHRLHEALEQGEFEVFYQPKVNLTTWKIQGMEALLRWQHPQLGLVTPATFIPIAEENGLIVAIGEWVLQTACTQNKAWQDALQPDLRVAVNVSAR
QFQQFNLLEMVANCLEKSGLAPKYLELEITETTAMQDVDYTTKVLTELQNMGVQIALDDFGTGYCSLNYLKKFPLNILKIDKSFVSGMTTDPCERAIAKA
VATLGRDLNLSVVAEGVETKEQLECLRSLHCQEIQGHYFSPALSAGEASKLL--------
>tr|F8GJR3|F8GJR3_NITSI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Nitrosomonas sp. (strain Is79A3) GN=Nit79A3_0663 PE=4 SV=1
----------------------------------------------------------------------QLEIALRNNEQLFRSLTEVAPVGIFRTDAA
GRCLYVNERWCSMAGMD-VVAAAGD--G----IHPDDREKVDEWNAA--------------NNPAGETIWIETSKVPL----EIIG-VLGIYQDITQQKQ
AHDSMR---TIYQSSNEAIMVTDENNRIIQVNPAFTRMTGYEIADVIGKDSTMLRSGWHNEAFYQDMGCKLLNEGCWQG----LRKDGIVHAKWLSIHVI
RHPDGRVHCHVAQFSDITEKNKKDEIILSQANYDQLTGLPNRNLFKNRLELEIRKSYCNESMLTLLLLDLDHFKDINDTLGHDKGDDLLREVALRIRLCV
DQSDTVARLGGDEFAVIVTNS-ANHAETLARKIIQELNKPFNFSSQINFISTSIGIVSYPQDGADMKSLMKHADQAMYAAKLQGRNRFCYFTASMQQEAH
EKMLLIHDLRQAIVKNELHVYYQPILELSSGRIIKAEALLRWKHPLRGMISPATFIPLAEESGLIVEIGEMVFKRSIALIDQWRQEY-GYIQISVNVSPI
QFKMN--NGRWFDHLSQMGLPGNCINVEITEGLLLKDSSVVQEYLLEFRNNGIEVSIDDFGTGFSSLSYLKKFDIDYLKIDRSFINQLIDNATDRALVEA
IIVMAHKLDIKTIAEGVETKEQQDLLIHFGCDYVQGFLYSIPIAQQAFELLL--------
>tr|H1G4A4|H1G4A4_9GAMM EAL and GGDEF domain-containing protein OS=Ectothiorhodospira sp. PHS-1 GN=ECTPHS_08121 PE=4 SV=1
---------------------------------------------------------------------CRAQKELQESEARYRHICAVTSDIAYACLRT
LQIDWMTDSIQAMTGYSVADIRDRG-SWE-FLVLDEDQA-IFKREILELEPGRASCCELRLRSKLGPPRWVRATSECIPSHPTGPVRLYGGLIDITEQKR
QQSRIQRLALVVEQSPSIVLVTDREARIEYINARFSQLTGFSREEIQGQPLALIHPHDAASPDLDGILHDLSAGRIWSGELAVRKKSGEHFWEQATLTPL
KNTQGDITHFVKMSEDLSDRKALSEQLSYLAHYDPLTGLPKRAVMRECLQQAMVRVRHNGDHLAIFSIDVDDLKRVNDSLGHAAGDELLRILSDRLQGLL
GKEDTLARLGGDHFLLLKAHMAQQDALHLAERIQQLVEQPLTIQDQSLVVTASTGIALFPGDADTVDELMRRGDAALHRSKSDGEGAYCFFTSTMDKQLK
DQFQLEQALRRGLERDELLLHFQPRVDMATGQIQSLEALVRWLHPEQGLLPPHRFIPVAESSGLILSLGPLVLRKTCEQIQRWRAAGIPVVPVAINLTTQ
ELYKQGLVTEVLATVSQHDIDPALLEFEITESTAMRSIDDARAILSELKTAGFTLSLDDFGTGYASMSYLSNLPVHGLKIDQSFIAELERDPATMAIVDA
MIGLGLNLGLEVVAEGVETPTQRDFLMAHRCTRGQGFLFSHPQPADVIGGLLQD------
>tr|F9U741|F9U741_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_0743 PE=4 SV=1
---------------------------------------------------------------------TASELGLAASENLYRRVTAMMSDVAYSCLEG
FRIDWMTDSVDALTGYSLAEMRTMG-CWS-CLLIEEDLG-IFNDKVAGLAPGSRTECELRLRRKDGTVRWLRATTECVAEGATALRRLYGGLVDITEHKA
REAEIERLALVVEQSPSIVLITDIAGTIEYVNARFCESTGYRPQEVLGQPVDILRSETRTLDENSAIWSALQHGEFWTGELQNRKKSGDAYWEYAHITPL
RDGQGLITHYVKLAEDISDRKRLSQQVSYLARYDPLTGLPNRTAMRERIEQALVASGHSDRILALLSIDLDDLRSVNDSFGHPAGDQLLRAVAERWQPLL
RDEDTLARFSGDNFITLATGLRREDASVLADRIREALAQPIALGEQGVVVSCSIGIALYPKDSTTAEELLSHADTALHGAKMEGRGLHRFFTSALNDDLQ
EQFRIEQALRRAIDRHELLLHYQPRVDILTGRIRGLEALVRWNHPELGLIPPGRFIPVAESSGLILLVGPIVVQLVCEQIAAWRRAGVPAVPVALNLSAT
ELYQSGLVGRIAKTAAEVGVDPGLLEIEVTESAAMRSIDQAVEVLSELRNLGFTLALDDFGTGYASLSYLNRLPVQALKIDRSFLAEIGSGGLAETIVKA
IIGLGANLGLQVIAEGVETEEQRTFLISHGCREAQGFLFCRPGPADRIERLLRE------
>tr|G4E4B5|G4E4B5_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Thiorhodospira sibirica ATCC 700588 GN=ThisiDRAFT_1144 
---------------------------------------------------------------------QRAEITLRRSEARYRHVSAISSDVAYSCTAR
FQLEWITETISLLTGYTREEMMANG-CWR-CLVHEEDLV-LFDEKVGLLEPGVCGEAELRLLHKEGLIRWVRSSAQCVLDGPMPIARIYGALVDITEQKI
QEAEATRLAQVVEQSASIVLITDVHGMIEYVNRRFCQVTGYMRHEAEGRSIDYFYPDNKEHAIIHTLWETVHQGETWKGELRGHKKNGELYWEQALVSPI
RDAHGEVVHYAKMGEDITDKKGLHEQLAYLTHHDVLTGLPNRILVAERIDFEILTCEREKRCLAVLSLDLDNFKVFNDSLGHATGDFLLREVAKRLRATL
REQDTLARFGGDTFLLLLTDLKQQDAGRVAAKIMRAFSKPFFVDDQALSVTASIGIALYPDDAHTSEDLILYADTAMHRAKEDGRQRYQFYTTALNDQLR
QRLQLEQSMREGISRGEFILHYQPRIDLNDGRILSLEALVRWQHPEWGLVSPGRFIPVAEQTGLILKLGPEVLRMACEQLKRWCKQGLPIVPIAVNLSAH
ELYQEMAVENIAGTVQSIGIDPRYIEFEVTESAAMRSIERSISVLSKLRSYGFHLSIDDFGTGYASLNYLSRLPVHVLKIDQSFLAALMSGSETAAIINA
IIGLGHNLGMEVIAEGVETVSQRDFLLKHECYIAQGYLFSRPLPVAEIEPLLRK------
>tr|G2E649|G2E649_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_3762 PE=4 SV=
---------------------------------------------------------------------QRTGQELRASEARYRQVTSIMSNVAYSCLDG
HRIEWITDSILSLTGHDANEVLSRG-SWR-FLVLAEDQG-RFDAHITTLPPGETSSCELRLRHKDGSLLWVRCTTECIQEIAPRVARLYGGLIDITEQKA
RACELERLELVVKQSPSIVLITDPHGDIEYVNQRFCDVTGYSHQEICGQHLNVLKSDTTPSQYIRKIWLRLMRGNSWQGELQHRKKSGELYWEQALITPL
RNDNGIISHFVKLAEDISDKKTLTEQLAYLIHYDPLTGLPNRTLMRERIDRALAAGRRNGHGLALLSIDLDKLKFINDTLGHASGDGLLREVARRLQTLL
GEDDTLARFGGDNFFLLAGHLGQQDSVRLAEQVNALLDEPIKLGANTVRITACTGISLYPEDAQTTDALIGHADAALHIAKGEGRRLYRFFTPVLNRRLL
EQFHLEQALRIGLERGELVLQYQPRVDITTGKILSMEALARWRHPERGLVSPSQFIPIAESTGLILDLGPLVLREACQQIQRWKAEGVPIVPIAVNLSAN
ELYQEDLTHRIQDIMAASQVDPAQLEFEITESAAMRSIDQAVTILSQLRSCGFTLSIDDFGTGYASLNYLNRLPMQAIKIDRSFLTEIDGKLNGAAIVKA
IIGLGSNLGIHIIAEGVETQAQRRFLIDHGCNVAQGYLFAWPLTPEEIEPLLRA------
>tr|W9VUD3|W9VUD3_9GAMM Diguanylate cyclase OS=Thiorhodococcus sp. AK35 GN=D779_3175 PE=4 SV=1
---------------------------------------------------------------------QTTERELLASEARYRKVTSIMTDVAYSCVSG
YRVEWITESILNLTGYDVREVLARG-GWR-FAILPEDLK-TFDTRIQTLEHGQTSNCELRLRHKDGSVRWVRCATECALQEDPPITRLYGGLVDVTEQKA
RESEFERLVLVLEQSPSIVLITDLNGTVEYANQKFCEVTGYSREEIRGQHVDVLKSDAVPCHMIREVWRHVIRGQSWRGEFQNRKKSGEIYWEQALITPL
RNEHGHISHFVKLAEDVSDKKALSEQLTYLIHYDPLTGLPNRALMRERIDRALASARRNGHGLALLSIDLDKLKFINDTLGHAAGDRLLREVGRRLQSLL
SDEDTLARFGGDNFFLLAGRLRQQDSVGLAEQVNAILDEQVILDADRARITACIGISLYPEDASSTDELIGHADAALHIAKGEGRRIYRFYTPVLNRRLL
EQFHLEQALRIGLERGELVLKYQPRVDITTGRILSLEALARWHHPELGLVSPSRFIPIAESTGLILDLGPLVLREACQQIQRWQSAGVPIVPIAVNLSAN
ELYQEDLTHRIQDIMSAAHVEPEQLEFEITESSAMRSIDQAISILNQLRSRGFALSIDDFGTGYASLSYLNRLPMQAIKIDRSFLAEIDGKLNGAAIVKA
IIGLGSNLGIHIIAEGVETQAQRNFLIDHGCNVAQGYLFAWPLTADEIEPLLRA------
>tr|W8L1X8|W8L1X8_HALHR Uncharacterized protein OS=Halorhodospira halochloris str. A GN=M911_00690 PE=4 SV=1
-------------------------------------------------------------------------------------------------WR-
--EVFLSPELKAQLGYRDHEMEDLE-AWR-SLIHPDERG-IRQFEQYTRQPQGRFRFEVRMRHQTGQWRWILHQASPVYGAEGNLRKILGSTLDITERKL
VEEQSKRLAYAVEQSPGVVVLTDTDGVIEYVNQRFCDITGFAREEVLGQQPGMLRYGEKNVEQCEELWATIRSGETWEGEFNNRTRSGEPYWEQARISPI
RNACGEVTHYIKLAEDISDKRALTQRLEYLAFHDPLTGLPNRSVMLDRIDRAIAQARRDQQTVAVVFIDLDDFKVVNDSLGHAQGDQLLIHIAQRLRTLL
REEDTVARFGGDEFILLLSSLTHEDVIPVIEKLQASLNQPVSLPSQQVSITVSIGIAVYPGDSDCPEELVRHADAAMYRAKAEGRRCYHFYIPEMDAALQ
ERMELDQAMRLALEQDQFHLVYQPRVELVSGRALSLEALVRWRHPQRGMISPGRFIPLAEETGFILSLGPAILRQACEQIRDWKARGVPTVPVAVNLSAR
EFREPGVVERILTVLAETGLDAGDLEIEITESAAMSSIDQTIRTLTELHGHGIRISIDDFGTAYSSLNYLKRLPVHAIKIDRSFVFEMEEDPADAAIIRA
IIGLGETLGLKVIAEGIENTVQRDFLLDHGCVQGQGYLFSRPMPAEEVEHMLLH------
>tr|H1G042|H1G042_9GAMM Uncharacterized protein OS=Ectothiorhodospira sp. PHS-1 GN=ECTPHS_00720 PE=4 SV=1
---------------------------------------------------------------------RATETALQESESRYRSLFENSHSVMLLIDPD
GSIVDANPGAC-----------QFY-GWE-RLTTHPSAL-PDPLSRER----P---IRDVHRLANGELRQVEIY--TGMI-VRGKDLLHAVVHDITERIR
AEEGLRLADRVFQAAAEGIMVTDVQRRIVAVNPAFTEITGYSAQEAIGQTPALLRSGKHDESFYEVLMQQLHDSGNWRGEVWNKRKDGTLYPEWLTISVV
RDDQGEITHYVGVFSDIGQVKEAQRQLELMAHFDPLTGLANRALFKDRLSHSLRKVKRQGDTLALLFIDLDRFKTINDTLGHNQGDLLLQTVARRMADNV
RASDTLARLGGDEFVLLLENDASSNIQTLCQKILAVLSDPIKLNEHEVVVTASIGVAVYPEDGRDAETLLKHADLAMYQAKNDGRNDYHFFAPDLSAGVL
ERLKLEAALCGACSRNELTLHYQPQIDLSTRHLQGVEALVRWMHPDLGMISPADFIPLAEDIGIIGEIGNWVLREACRQMHQWRRDGLPVPQVAVNLSVQ
QLERGNLVIQVRRALSDFNLPAHCLELEVTESLIMRAPEKTLSTLQELKSLGVRLAVDDFGIGYSCLSYLRRLPLDRIKVDQSFVRDVGGGTSDETIVRA
IIGLGRSLGLETVAEGIEETRQVEFLLREGCLSGQGYLFSRPLPAEDLTAQWGE------
>tr|H8Z5X8|H8Z5X8_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiorhodovibrio sp. 970 GN=Thi970DRAFT_04282 PE=4 SV=
----------------------------------------------------------------------------------------------------
----------------------RVG-GWE-LFFHPHDRA-IERALREGV-----FALEVRLTTARGQALWVKIAGDPVYRGKGGILKLIGSLQDITERID
ADNALRRTQTVFEKTSEGIVFTDAETRILMVNQAFSEITGYSEDEVLGKTPQMLRSGRHDDAFYKAMWTSIEETGSWRGEFWNRRKSGEVYPQQSTISAM
HNDAGELTGYIGVFGDLSSLRRSEEALYRLAHHDILTGLPNRALLRASLEQSLARARRSKKLLALLYLDLDLFKNVNETLGHPVGDQLLQQVATAMQKAI
GDSCLIARVGGDEFMVVAEDLAESVAGRLAARILNCFAEPFSADDRELFITASIGISLFPADGDDIDELQSHADLAMYQAKEHGRNTYRFFEATMTSGVS
DRLRLESALRGALARDQLWLAYQPQIALEDETLVGVEALLRWQHPELGLISPGVFIPIAEETGLIREIGDWVLEQGVRQLAQWDRDGIKVPRLAINLAMP
QMESPELVAQVRGVLERTGVSANRIELEVTESMLMRNIDQVRANLEALREMGVYLAIDDFGSGYSSLRYLKRLPIHRLKIDRSFVEQLTQDPNDDAIVRA
VIVLGRSLGLAVLAEGVETRAQADFLAAEGCHEVQGFLFGRPVPPEEISARLRA------
>tr|W8L5P4|W8L5P4_HALHR Uncharacterized protein OS=Halorhodospira halochloris str. A GN=M911_08460 PE=4 SV=1
---------------------------------------------------------------------RATEAALSESEARYRSLFENTHSIMLLVDPD
GQIVDANPGAC-----------QFY-GWT-RINALSDKE-MARVQRGG----H---FRFVHRLATGERRQVEVY--SGRI-VEGRELLHSVVHDITERNR
AEERLRLADRVFQAADEGIMVTDMQGRIVAVNPAFTRISGYTEEDALGQTPALLHSGRQDTSFYQRLWRNLLQLGHWRGEIWNRRKNGEIYPEWLTISAV
RNDDGEIIHYVGVFSDIGQIKEAQQQLEFMAHYDPLTGLANRALLRDRLKHALRRAERKNATLTLLFLDLDRFKTINDTLGHNLGDLLLQTVAQRMKNTV
RASDTLSRLGGDEFVLLLEDEINQEINTLCEKLLNVLEAPMLLEGHELVITASIGVATYPDDGVDADALLKNADMAMYEAKTQGRNAYEFFVPSLSEGVM
DRLKMESALRGAAARNELRVHYQPQVRLKGGSLLGVEALARWEHPTLGLVSPGHFIPLAEEMGVIGEISAWVLREACRQMRVWRDEGRDVSCVAVNLSVQ
QLERDMLVSTVRDCLAEYNLPAECLELEVTESLIMRAPEKAQSVLQKLKMMGVKLSVDDFGTGYSSLSYLKRLPLDRLKIDRSFIQDIGLDTNGEAITRA
IIGLGRSLGLETLAEGVEQKEQVQFLLKEGCDLAQGFLFSRPVPPNQLVFHWDC------
>tr|F9U596|F9U596_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_0097 PE=4 SV=1
-----------------------------------------------------------------------SEAALAESERHYRLLADHATDMISVHDVE
SRYLYVSPACR-----------TLL-GFD-AFIHPEDHL-LAAQQRAGLEAGPLPTLRYRLRRADETHIWVETTSRQCRA-AGGELTLVATTRDITERRE
AEERLRQAARAFESAAEGVTVTDARGNIVSVNLAFTEITGYSEAEVLGQNPRILQSGRHGRAFYEGMWASIGTTGRWCGELWNKRKNGEIYPEWMTIASV
YDDVGTLTNYVAVFADISALRESESQLVFLTHHDALTGLPNRVLLRDRLEHAIAHAARARSPLAVLLVDLDRFKTINETLGHPAGDSLLQQVARRLASRI
RGGDTLARLGGDEFVVLLEDGVSRRAGVFAANLLSVFAEPLTLDDRKLYVTVSIGISLFSSNGETADDLLRHADTAMYTAKEMGRNTYQYYEPDLTASAF
DRLRLENDLRAAVRRGELLVHYQPQIQLSTGRLAGVEALVRWQHPEQGLLAPGCFISVAEEMGIIDEIGVWVLRAACVQMMDWDASGLSVPRVAVNLSAQ
QLGRDSLVGQVSDILEETGLAPARLELELTESMIMQRADRAIDALRGLRALGIAIAVDDFGTGYSSLGYIRQLPLNRLKIDASFVQDLDAAEDGGMIARA
IIGLGKSLGLEVIAEGVEREAQNAFLRREGCDIGQGYLYGRPMPAADLCASWGS------
>tr|I3YD08|I3YD08_THIV6 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiocystis violascens (strain ATCC 17096 / DSM 198 / 
----------------------------------------------------------------------------------------------------
----------------------KVG-GWE-LFFHPSDRF-MDLAISLGQ-----FDIQARLVTTNDRPLWVQVACEP-VM-HGVATKLLGTIQDITARMD
ADKSLRQAARVFENTAEGVVITDPEERILAVNRAFAEITGYAEEEVLGATPRILNSGRHDAEFYQAMWAELNRSGQWRGELWNRHKNGQIYPELMTISAV
VDGNGELTHYVGVFRDISHLKRSEEKLEYLAHHDPLTGLPNRSLFQARLEQCLQRAARHQRQVGLLFLDLDRFKIVNDTLGHSIGDGLLQQVAETLSKQV
RAADTIARLGGDEFVIILEDIPARFAANFAERLMTAFSQPFNVEGHELFITASMGISLYPQDGEEIDALVRHADIAMYQSKNGGRNGFSFFESAMTEGAA
ERLRLEHDLHGALLRDEFVLHYHPQLALADGQLRGVEALCRWQHPTLGLIPPNQFIPVAEDIGLIDRLGAWVLEESCRQMIVWDQAGFHVPRLAVNLSVR
ELERADLVDEIREILHRTGVAPERLELEVTESMIMRNAELAIKTLAALRGLGVTLAVDDFGTGYSSLAYLKRLPLHRLKIDRSFVEKLTQDSNDDAIVRA
ILALGRSLGLETLAEGVETQAQVDFLLQEGCIEGQGYLFSRPVPAADLVATLF-------
>tr|L0GZZ2|L0GZZ2_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thioflavicoccus mobilis 8321 GN=Thimo_2815 PE=4 SV=1
---------------------------------------------------------------------VLAEQGLRVRERQLAAIFRAAPVGIGLIK-H
RQILHTNDHFAELLGYRQDEIIQLG-HWE-LLFHPEDLL-LRRSMTEGV-----FEYVLRIRRADGAIRFLSAQGQARKD-NGEVQSLFGTAQDVTEQHL
AAEHARQAAKVFESTADGVMITDAAERILAVNRAFTEITGFSEAEVLGHTPRLLQSDRHDRTLYQAMWASLRRVGSWRGELWNRRKNGELFPVLLTISAV
SGPDGAVTNYVAVFSDMTSLRRSEEQLEHLAHHDPLTDLPNSSLFRSRLEHGLQRAERDRRALGVLIMDLDRFKVINESMGHASGDEILRQVSLSLGEAL
RSGDTLARLGGDEFGVILEDLKDSAAVAIAQRLMELCARPRELAGREIAVTACVGIGIYPADGRDGESLLRHADVALSKAKDEGPHAFQFFEPMMERGAI
ERLHVESCLRHAQERGELTLHYQPQIRLADGALVGAEALLRWHSAELGQVPPGSFIPLAEEMGLIDEIGAWVLRRACEQLLAWEAGGLCLPRVAVNLSIR
QIEQGDLVERFGEIFRQTGVATEWIELEITESMVMRRADLSVEALNGLRDLGVRLVVDDFGTGYSSLAYLRRLPLHQLKIDKSFVDDLLDDPNSRAIAQA
IIALGHSLGLEVLAEGVELAEQAQILRSDGCDLAQGYHYARPLPPDELVERWLR------
>tr|G2DVF4|G2DVF4_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_0124 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------KIG-GWE-LQFHPKDAA-LDRASNEGI-----FDLSVRLDASSDSQRWLQITCQP-LQ-AGSVVRLLGAIQDITARVE
AEKALRQAARVFESTAEGVIITDPEARILAVNRAFTEITGYSEAEALGGTPKLLRSGRQGDDFYDRMWRGLSDHGHWRGELWDRNKNGEIFPVLLTLSSV
LDDAGELTHYVGVFSDISHIKRAEERLEFLANHDPLTELPNRALFQKRLSECIQRAERYQRQFALLFIDLDRFKDINDTLGHLFGDALLKQVAAILGHQV
RSVDTIARLGGDEFVIVLEDIPARFAARFADRLMEIFAQPLSVESQELFITASIGISLYPQDGCDIESLVRHADIAMYQAKNAGRNAFSFFEPLMSEGVA
QRLKLEHELRGALSREEFVLHYQPQLTLDGRRLRGVEILCRWRHPELGLLPPERFLPMTEELGLIDALGYWILEQGCRQLAHWDQSGVKVPRLAMNLSVR
ELSNEDLVPRIRETLEHYGIAPERLELEVAESKLVRCSEASLANLSALSAMGVTLAIDDFGVASPALASLQRLPLKRLKIDRSIVESLAADSGGRILVRA
ISGLARGLGLEIFAEGVETAEQADILRLEGCDEGQGFFFCHPLPPKDLHLVWPL------
>tr|G4SVS2|G4SVS2_META2 Putative Diguanylate cyclase OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) GN=MEALZ_2451
---------------------------------------------------------------------DLTS---------------------------
----------------------SLG-VWS-GLRRPVIH---ALDNKKGL--------------PEGHATLLRHVSVPVIE--DNVVMIMGV---------
------LDAMVFRYSREAVVVTDGEQRILSVNPAFTLITGYTETEVLGLTPRLLKSGKHDDSFYQQMWAKLNLEDYWQGEIWNRRKNGEIYPQWLGISAA
RTPEGRPSEYIAVFMDITEHQQAREYIEFLAHHDPLTSLPNRTLLKDRFQQTVSYVQRQGKKLGLLYLDLDHFKNVNDSLGHPIGDKLLLEVACRLRDCV
READTVSRLGGDEFVVLLGNVHHDNLADISTKILTALLRPFDIEGNKLQLSCSIGACLYPDDGEEFDGLLQKADTALYQAKFNGRNTYKFYTESMNVAVM
RRMSLENAMRLSLEREDFFVVYQPQFDIKSGQIVGAEALARWHHAELGIISPAEFIPVAEECGLIVTLGQSVLRQACRQMQQWLLQGHY-LRVSVNVSCV
QFLRHNLLQTVIEILEETGLPPHHLELELTESILVTDPEYVLQVVNTLNQRGVQFSIDDFGTGYSSLSYLKRFAVDKLKIDQSFVRDIPGDADDEVLVEA
IVNLAHNLRLKCIAEGVETQVQADFLRQLGCDQIQGYLLGRPLSVDAMQQLLSS------
>tr|G4E2H0|G4E2H0_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodospira sibirica ATCC 700588 GN=ThisiDRAFT_0499 PE=4 SV=
----------------------------------------------------------------------------------------------------
-------------------------------------VA-LDALKTGQT-----LEFENRYRCRDGTYRWLAWNSYPD----IPNQRLFAVVRDITERKL
HEDALRQAATVFENTRDGVIITDLQPRILGVNRAYTDITGYTHDEVFGLNPRILQSERHHKAFYQAMWRSIKDNGYWQGEIWNRRKSGEIYPEWLTISTV
RNADGQPTHYVGVFTDISRLKKTEARLEHLAHHDPLTDLPNRLLFLSRVQHALASARRRKEKIAVLFLDLDRFKTVNDSLGHPSGDELLVAIAKQIGARL
HSEDTLARLGGDEFLILLESVERHQAADIAQDLLETLEAPFTLSGHEVYIGASIGISVYPDDAHGETELIQHADAAMYKAKDQGRNSFHFYTQEMTQAAI
ERLELETAIRRGLEQNEFVLHYQPLIDLRTEKTVGFEALIRWQHPQKGLIYPAAFIPAAEETGLILALGKWVLHTACTQCRRWLDEGIAPAFVAVNLSAR
QFQGQEIDQQVREALDRTGLPGHYLELELTETMVLEPGETAAQKLATLKTLGIQLAIDDFGTGYSSLAYLKRLPINKLKIDRSFISNMIEDEDDQQLVST
IINMAHNLRLSVLSEGVETQAQAELLKQMGCDFAQGYFYSKPQPAEYATARLRA------
>tr|C4L987|C4L987_TOLAT Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Tolumonas auensis (strain DSM 9187 / TA4) GN=Tola_0356 
---------------------------------------------------------------------ANALIALQNA----AEVIDASPTILFRWQP-
---------------------------WK-MLLHPEDLE-VIHHIETRH---YILECRV--RTAAGEYLWVENHVTTSFD-KGKPQRFTGVMTDITQQKN
NELQLRQAAIVFESTREGIVITDAERNIIKVNRALIDLFGYPENELLGQRPRIFHSGKHDGHFYQQMLQALDEHGFWRGEMWNRRQNGELLPMMTSINPV
CDSNGEILYYISIYTDISQLKDSEARLEHMALHDPLTGLPNRAMLGQKLDSALQHAMLNSTRVALLMLDLDHFKNVNDSFGHHFGDELLHQVSARLKQQL
RESDVVCRLGGDEFTVLLQNNPSDDVSLLAERIIHALHQPFLLNAREVMIGTSIGISLYPEHGSTAEELMQQADTAMYRAKHDGRDGYRYFSEELFLKAK
ARLELEQRLHRAITGQEFKVFYQPQISIKTNQIIGAEALLRWDDPEYGLIPPSEFISVAEETGLIQNIGEWVLYETCRQGRDWLDQHLPPINLAVNLSPL
QLHHGDVRQLIGTILHNSGFPAHHLELELTESALMEQQEETVKILQGLRQQGIRIAIDDFGTGYSSLAYLKQFPLDVLKIDKRFVEDIPHERDDMEIAAT
IVAMGHSLRLTVLAEGVETKAQLEFLEQQGCDYYQGYLYSMPLPAEEFAQLLSQ------
>tr|A0A081FT35|A0A081FT35_9ALTE Diguanylate cyclase OS=Marinobacterium sp. AK27 GN=ADIMK_4147 PE=4 SV=1
-------------------------------------------------------------------------QALETA----NQIIESSPVVVLRWSS-
---------------------------NQ-LLVSPQDRL--IQGVV-SR---QLSQCRFRVLTGDGETRWVEAQIICHAT--DQSGCLEALVRDVHARKQ
HEDSLNLAAAVFRSTREGVVITDANQRILEINPACSAMLGYEPEEVIGKTPKLFSSGRHGADFYATMWRDLQAEGYWQGEIWNRRRDGQLIPELLSITRV
DDPDGGDRRYVAVFADVSEIKRSSEKIEFLAHTDPVTGLPNRALFQSMLEQAIRSGKRQSHEVALLILDLDHFKDINDGYGHGIGDELLQQVAQRLQQHL
RGSDSLARLGGDEFAVLLTDLGRLDAASVARQLIELMSEPFHLNGADIQSGVSIGISLNQHADHDAQEMLKQADAALYKAKSLGRGSFSYYSNDLSKRAA
ERLDMEVRLRRAMQQGLLEVHYQPQVEITTGQIIGAEALVRWHDEERGYIPPDQFIPLAEQSELIVKLGDWVLEQVCRQGKAWLDQGYPELQLAVNLSPG
QMRSNDLVTRIAEIVNRTGYPARLLELELTEGALMHDPEVATQRLTELRELGICLALDDFGTGYSSLAYLKRFPLSVLKIDKSFVRGLPVDSDDCAISRT
VVAMGHSLGMSVLAEGVETEQQLKYLQGLGCDIYQGFLCSPALPEQSFIELLRA------
>tr|B1XZA8|B1XZA8_LEPCP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) GN=L
---------------------------------------------------------------------VDARAALQRSEASLRLAVDGSGDGLWDWDL-
----------------------------K-IRLHPDDRA-VRNSIEY-G---F--VATYRMRCFDGEYRWFQGRGMCHRD-HGTPQRFSGVLTDLTDRLQ
AEERLRLAAQVFDSTQEGVMITDARRRIVSVNRAFTTLLGYTETEVLGQTPRMLSSGRHDRDFYEAMQAQLDHTGLWQGEIWNRHKDGSPVPELLSISAV
RDPHGQVTHYVGVFTDITHLKESEARLEFLAHHDPLTHLPNRLLFNNRLDQALHQAEREGRRLAVLLLDLDRFKDINDSYGHLAGDELLKYVAQRLTQRL
RQSDTLARLGGDEFALLMHDLRHDDAARLASELLSGLSEPWRSEGVEVSVGVSIGICIYPDHGRTPQTLLQGADAALYRAKGDGRGVYRYYADEMTRIAR
ERLHIEARLRRALADGQLLLHYQPQVDLRSGRIIGAEALVRWQDPEQGLIPPVRFIPVAEATGLIGEIGAWVLGEACRQARAWLDAGLPALTVAVNVSPR
QFHQADLATQVMQVLVETGLPPTHLELELTEGALMEREAEALQVLQRLRGLGVGVAIDDFGTGYSSLASLKRFPIDVLKIDRSFITDIPDDPDDMEIAAA
IIAMGHSLGILVLAEGVETAEQLAFLQQRNCDRYQGFLRSRPLPAQAFEQLLRE------
>tr|G0A0Q5|G0A0Q5_METMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomonas methanica (strain MC09) GN=Metme_1570 PE=4 SV=1
----------------------------IQYNQQGKEEGAV-VCATD---------------ITP---LKQQQERLHHSESLLREAQHIAHLGHWEQDLA
TSELTWSEEVCRIFELDADHCPPTFPILI-DPVHPDDRAAINKAYLASQTVDKPITIDHRLLFADGRVKWVRKCFITHRDADDRPSRLVGTVQDITAERL
IDEQLLLAASVFESSLNGILITDAGGRIIKVNQTFTEILGYSPEEVLGHKPGLFKSGYHDKDFYRKLWSTLKLAGKWQGEIWDQRKNGECVPLWQSISAV
SDSEGHVIRYIGVFYDLSEQKRTAEHIHHLAYYDSLTDLPNRQLFTERCELALENVRRTHQLLAVLFLDLDRFKHVNDSLGHPVGDELLRAVAQRLKNIL
RHGDTVARLGGDEFIVLLDDVENEIIEHVATKILEGFAKPFMAREHKLEIGTSIGISRYPEDGKDATTLIKHADLALYQAKEQGRGMFQFYDVRLTERAK
ERLFLESELREALVREELLVHYQPQYSLADDRLIGAEVLLRWHHSEHGIIPPDKFISIAEDTGLIVPIGEWVLQTACRQAKTWLAAGYDFQRMAVNLSGV
QIERSDMLATVRQVLKDTGLPANYLELEITETYIMQQAQQNIRIMEDLRALGVALAVDDFGTGQSSLGYLKRLPVDKLKIDRSFIMDIPQDSNDMAITRA
IIALGHNLHLTVLAEGVETAEQSAFLKELGCDEAQGYYYSRPLEAASYERFLKKRPASV-
>tr|G4SY70|G4SY70_META2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 /
----------------------------LQHNPQGKEEGAV-ICASD---------------ITR---LKQQQERLSRSEKRLKEAQKIARLGHWEMDLT
CDKLTWSEEVCIIFELDSASIPRNYADFL-ELVYPADRAAVDRAFTSALSTHGSYDIEHRLLAAGGQIKWIHERCVIYYDDAGRALRLVGTIQDITEQRL
AEEQLRLAASVFDNSLNGILITDANTRIVKVNRMFSEVMGYSSDEVLGQKPSLLKSEHHDKQFYRSLWAALERDGKWQGEIWDRRKNGELIPLWQNISSV
RDAIGRVTHYISVFYDLTQQKQSAKHIYHLAYYDALTELPNRQLFNERCEHALERANRDYHPLAVLFLDLDRFKHVNDSLGHPAGDELLRMVAHAIKSSL
RQDDTVARLGGDEFIILLENTGSSDVEQVARKIIAYLSRPFIVQGHKLEIGTSIGISCYPEDGKDTMSLIKHADLAMYRAKEKGRGNFQFYETYLTTRAK
ERLFLESELRDALERQEFHLHYQPQFALSGGELIGAEALLRWNHHEHGLIAPDKFIPIAEESGLIVAIGEWVLSAACSQAKAWLDAGYAFKQVAVNLSGA
QIERSDILATVGNVLATTGLPPQHLELEITETYIMRQAKQNVRIMEELRALGVSLAIDDFGTGQSSLSYLKRLPVDKLKIDRSFVMDIPQDSNDMAITRA
ILALGHSLKLTVLAEGVETAEQAAFLNELKCDEVQGYYYSRPLDAESFRKLLAKQKFDA-
>tr|B1Y6A9|B1Y6A9_LEPCP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) GN=L
----------------------------MLYSAQNKEEGAV-LSGTD---------------ISE---LKRQEQHLRASDARFNQAEHVARVGSWDLVPH
TGAMTWSVEMARIFDITAQPHAYSQADFL-AAVHPDERARVVAAQAAASAEHRPCDIEFRIVTSGGKMKWVHLRSTTFHGDDGRPLRSVGTVQDITERRQ
AEDEMRLAASVFDNSLNAILIADANGRIRKVNRAFTAITGYTAEEAVGDTPRLMKSGLHSPGFYGEMWAELQACGKWDGELMNQCKDGRIISVRESIAAV
HDPAGAVAYYIGIFHDITEQKASAQRIHQLAYYDVLTGLPNRALLMDRCQHELARAMRDGKRLAVLFLDLDRFKHINDSLGHPVGDGLLRAVAQRLQGTL
RDSDTIARLGGDEFIVLLEHVETAGVELAARRILDAFRDPFQLEEHRLSVGASVGISLFPDHASDITSLFKYADLALYQAKAAGRGDFRFFEPRFNDAAK
DRMRLERELRQALERNQLSLQYQPVFALPDGRLAGAEALLRWTHPALGSVSPATFIPIAEDSGLIVPIGAWVLEQACRQARQWLDAGLDPGVIAVNLSGM
QIQRNDLVDTVSSVLARTGLPACHLELEISESYITRHAESDLQRLGQLRALGVSMAIDDFGTGQTSLGHLRRLPVSKLKIDRSFMADIEHDAAAAAVTRA
IIGLGHGLGLTVVAEGVESAAQESALVAQHCDLVQGFRYARPLDAPVFAALCARPQPLR-
>tr|K4KM56|K4KM56_SIMAS PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Simiduia agarivorans (strain DSM 21679 / JCM 13881 / BCRC 17
----------------------------L-RDLPGTD-ELI-LIIRN---------------TTD---IHQKTEALQSLQQQLNLALEAAQQGVWDWNVP
SQTWVANERFFTMLGFDYDAKPQPLDYWN-DKVHPDDRDKRSSLYLKAMRDAEALEVEFRAQSASGEYRWLRAKGKVVRTKDGRAKRLVGTHEDITERKA
LQEQLALAAMVYENTSEGVIIADPNGIIVDVNTGFERITGYDKREVVGKPASILNSDNHSESFYQSFWDTLNQNGHWQGEIVHRRKDGTALPEWLTASAV
YDHNHAIRHFVAIFTDITVLKKSEAKLDHIAHHDSLTGLPNRLLLQARLGRALVHASRNQQKLALMFLDVDRFKNVNDSLGHNEGDKLLKQVANRLKHSV
RNEDTVARLGGDEFVILLESLHDNAAAQVADKILKEIRQPFNLGGKQFYTSASIGISIYPEDGTSPSDIMRNADTAMYQVKQRGRDGYAFYARHLTTAAM
RKAEMEAELHKAITGDELLLLFQPQIDLDSEQLVGVEALVRWMHPVKKMIAPDLFIPLAEESNLIIKLGEWVLNRACRQINEWQDMGLTPVPVAINVSGV
ELYNQSFADSFREIMATHGINPQLIKVEVTENHMLEDMDSAIQQLNKLRELGIKIAIDDFGTGYSSLAYLKKLPIHQLKIDRSFIKDIPQDVNDMAITRA
VIAMGATLGMEIIAEGVETREQQKFLQEHQCGLGQGYLFARPLDAKSLENWLDHS-----
>tr|Q2BQI6|Q2BQI6_NEPCE Uncharacterized protein OS=Neptuniibacter caesariensis GN=MED92_05488 PE=4 SV=1
-----------------------------IFNRQGEIESYQ-SIGED---------------ITQ---RMIQERALESSEAQLSTLIQCLNNRNWTMLY-
-----LSDRCEEIFGYTAESLISRYCSYA-QLIEPGYREYVWAAVQNSLKTQTPYKVLYKLKHSSGESRWMEEQGRGVSTDS-TGLTIEGYIEDVTERIE
AENRLNQAAAVFRSTGEGVAITDQNGTIVDVNEAFTKITGFDRDEVIGKNTRILQSGKHDIAFYENMWEQIQKHGHWRGEVWNRAKSGTIYPEILTISAI
DFKKGQPSGYVGVFADITSLKETEARLDHLAHYDALTELPNRLLFRERLIHSLLMSERKKTKVAVLFLDLDRFKNINDTLGHGVGDILLAEIASRLRHVV
RMGDTVGRISGDEFCLILEDIQDTDVVPIVEKILSVFSQTIQINSHMLQISASIGVAISPDNSNDADALLSFSDSAMYEAKEAGRNTYKFYTAEMTQQAL
EHSFVQSALRDALEQSQFFVTYQPQLRIKDYSMVGVEALVRWQHPERGLIPPDSFIPIAENSGLIRELGAWILRTACEQGVQWLNEQVNFGRIYVNVSAT
QLHDESFTEAVIMCLKETGFPAEKLGLEVTESFIMKDPQHAINVLSSFKEIGIELAIDDFGTGYSSLSYLKQLPIDKLKIDQSFIRDIPDDPNDMAIAEA
VIAMGKALNLEVIAEGVESQIQADFLLDKECTEVQGYLYAHPLTADAFSEWEKQRDIK--
>tr|F3GGD7|F3GGD7_PSESJ PAS:GGDEF protein (Fragment) OS=Pseudomonas syringae pv. pisi str. 1704B GN=PSYPI_29044 PE=4 SV=1
----------------------------LAWDAEDRVTRII-GIAKD---------------ITE---QVASSQSLRDSEQRYRMLASTD--GRLAVNY-
-----VSPSVERALGYSAEWILPQQIVGF-D----ALMDRIDKVLDKRLREVTIRMFLFDCLRADGRKIPVELRVVLVWGEHGNFEGIFGVGRDISQQRR
AEKDLRMAATVFEHSTSAILITDPAGYIVQANEAFTRVSGYEVAQVLDQLPGMLTVESEQETRLRHILRQLNGQGTWEGEIRLRRRNGEHYPAWVGITAV
LDDEGDLASYVCFFSDISERRASEDRIHRLAYYDALTHLPNRTLFQDRLHSALQHAERQQAWVVLMFLDLDRFKPINDSLGHAAGDRMLQEMATRLLACV
SVDDTVARMGGDEFTLLLEPDETNRAIHVAERILTSLITPFVLEGREFFVTASIGIALSPQDGKELSQLMKNADTAMYHAKECGKNNFQFYQADMNATAL
ERLELESDLRHALEQKEFTLFYQPQFSGDGKRLTGAEALLRWRHPRRGLVPPNDFIPVLEELGLVVEVGDWVLAEACRQLKHWHQARVRVPKVSVNISAR
QFSDGQLGKRIAHILEQTGLSPACLELELTESILMREVNEAMQILDGLKNLGLSIAVDDFGTGYSSLNYLKQFPIDVLKIDRTFVDGLPSGEQDAQIARA
IIAMAHSLNLSVIAKGVETHEQLEFLREHDCDEVQGYLFGRPMPPAQFEAQFSNDALFM-
>tr|F9U742|F9U742_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_0744 PE=4 SV=1
------------------------------EMAMDGDEVFV-VYLRD---------------VTE---HKLAQAGLNERDRLVRMAADLARIGAWDVDLL
ANRVTWSDEVCRIHEVPPGTVV-PVEDGI-SYYAPEWRERITRVFTACARAGVGYDEELQIITAKGRRVWVRTIGAAVRDVSGRIAHVQGAFQDITERKT
AEEGLRLSAAVFESTSEGVVITDTTPLIIAVNPAFTEINGYPPEEVLGRNPSLLKSGRHEQPFYEEMWQALLDRGHWRGEVWNRRKDGEIYPQWVNINAV
RSELGQTTHYVGVFSDLSDVKRSEAQIERLAHRDPLTDLPNRLLFRTHLEQALLRAGASRARVGMLLVDIDGFRHINDSLGHAVGDLALREVAKRVTLLA
HVEETVARMSGDELALLLEGDDDTRAALMAERIRESLNKTFTVDGSELFMSASIGIAIYPDDGTDVSELMQNCDAALYQAREAGGNTYRHYARGLTDYAR
ERVTMSSELNRAIERDELQLHYQPLVDTASSRVTGLEVLVRWQHPERGMVLPDSFIRLAEETGLIIPLGAWVLRHACLQAREWEAAGIPFGRIAVNVSGV
QIQRSDFARTLESILHETGLGAERLELELTETFVMDLREDAQQLLGDLKDLGIALAMDDFGTGYSSLAYLKGLPFDTLKIDRSFIGGLPDDPASAAIVTA
ITTLGNSLGFEVLAEGVETQAQRRFLIGVGCRRAQGYLFSPPVAPEAVVRLLTRAARHA-
>tr|L0GWU8|L0GWU8_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thioflavicoccus mobilis 8321 GN=Thimo_0953 PE=4 SV=1
------------------------------DMEMRGEPVTV-VYLRN---------------VTE---RK------------------------------
---------------------------------------------------------------------------------------------------Q
AESRLRLFAAAFGNTSEGIMVTDTGPVIITVNEAITEITGFRTDELLGRNPSVLKSGYHGRSFYREMWQQLLGQGHWRGEIWNRCKDGQIAPQWLNINAV
RNDVGQVTHYVGVFSDISDIKRSEAQIERLAHRDPLTNLPNRLLFRTLFEQALSRAQTNNSQVGMLLVDLDAFRHINDSLGHGIGDQVLCEVASRLTALV
RPEETVARLSGDEFAVQIESDSAARASLMAERIIDALGQPLTLGGERIFISASIGIATYPADGSDVTRLMQNSDAALYQARECGGNGYRHYASALSDYAR
ERIVLIADLHRALAEDELVLHYQPQIDMRRGCVIGLEALVRWRHPQRGLLGPDQFIHIAEETGLIIPLGEWVLRHACRQALIWQAAGLPFGRIAVNVSGA
QIQRRNPVETVAAILAETGLAADRLELEVTETVVMDLRQEAPAFLAGLKRLGIALAMDDFGTGYSSLAYLKGLPFDTLKIDKGFISGLPEDEASAAIVDA
ITALAGRLGFKVLAEGVETEAQRRFLLGVGCDLAQGFLFGHPAPAEETTTLLRQPATPP-
>tr|W8KHE0|W8KHE0_HALHR Diguanylate phosphodiesterase OS=Halorhodospira halochloris str. A GN=M911_08450 PE=4 SV=1
------------------------------RLEIAKGLLFV-LV-TS---------------VLL---LRSWAHRLEDSERLMNMAAGLAHVGGWQVDLQ
TGVVHWSREVCRIHDMPPGTRV-KVEDGI-AFYAPAYRDRIRQVFRACAEEGIPYDEEMQILTREGKPVWVRTIGRAVRDEQGRITRVQGAFQDISARKR
DEAKLRQWATVFESSDEGMIITDDRARILMVNASFTRITGYGPKEAVGRNPSLLSSGRHTRLFFRRMWDTISLTGGWRGELWNRRKSGELYPQWSTINAV
RDAEGRLTHFVGVFSDISDLKSSQEQIERLAHRDALTNLPNRLLFRTRLEQALIRARSHASQVSVLLLDLDGFKHINDSLGIRMGDQLLSSLAERFTAIL
QRGETLARMGSDEFAILVEQGADARVEQVAEAIIQAVQLPVKIRNNDVFITASIGIASFPQDGHEQDQLLQHSDASMHHAKQAGGNTYAQYSRDFTDYAR
DRVLLAADLRQALERNELVLHYQPQVDLISGEVVGLEALVRWEHPTQGMISPGRFIPMAEDTGLILPLGRWVLRQACVQARAWREAGLDFGTVAVNVSGV
QVQRSDFVETVGAVLRETGVDPALLELEITESFVMDRRQGSEELLRQLKSLGVFLAVDDFGTGYSSLSYLKSLPFDALKIDQSFIRGISLNPHDAAIASA
ITTLGGHLNMEVLAEGVETREQQEALLALGCHRAQGYRFSHPVAAKDIPEILRRATLMP-
>tr|Q2BJL1|Q2BJL1_NEPCE Signal transduction protein containing membrane, EAL and GGDEF domains-like OS=Neptuniibacter caesariensis GN=MED92_09441 PE=4 
----------------------------LLFNHQGKEEGLI-LSATD---------------ISE---KEK-VRRQKDLEQHILLLKATLVQGVAMFDEQ
GDLLIWNEQFSQIAQSNLQNIDARYQDLF-T---QN--TLVQNAQLQ-----------SSSQLLREKYRWIQHQVNGSCESSPPSGGFVISTRDITQSRR
DEEHIRLLSSTVEQSTNEVIITDTDGIIVYVNPMFTENTGYLPEEAIGRKSSIVQSGEMSAEFYRNLWETIKKDNCWKGEIINRKKSGEKFWQSMSISPI
HDETGAISHYLSLKSDITKQKEAERQLRYQAEHDLLTKLPNRPVLLAEMDSAIDDARNNHCFSAVLFMDLDNFKDVNDTLGHLSGDFLLQLVAKRLEQCI
SITDVIARLGGDEFAIIQRGIKSHEPSVLAEKVINAITTPFRVDDHLLHIGISIGITLIPEDGLETGMLLSNADMAMYEAKAISGSHYKFFDHDLQLSIQ
RKRLIESHLHNAINNNELNLLLQPKIEIHTGHIVGAEALLRWHSTEIGQVSPAEFIPIAEKSGQIIELGNWVLNQALQLIKDWCQKGYKIPKIAVNLSAV
QLKDVNLVQDIKKALEHYQVHSEYLELEITETAAMSDPEFSNSQLSAIKAMNITLAMDDFGTGYSSLSYLASLPIDRVKIDRSFVSDIQHSNEARGIIES
IIHLGKILNKTVIAEGVEETEQLELLKRLGCHEAQGYLISRPVASSEFIALLGKADS---
>tr|L0GZQ9|L0GZQ9_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thioflavicoccus mobilis 8321 GN=Thimo_2055 PE=4 SV=1
----------------------------------------------------------------------AQNQALRDSEARYHSLFENDHAAMLLVDPD
GRIVDANPAACRFYGYSLERLNAAGVGLL--DTRDHQNPLLLGELGSSGPDHFE----GRQRCSDETTRPVEVYSSAV--TIGGRRLRFCIVHDITQRKR
AEEALRLAAAVFECTRDGVVITDLTPGIIAVNRAYTEITGYTEAEVLGKNPAVAASGRNDKDFYERMWRCINDTGYWQGEIWNRRKGGELYPQRLTISVV
HDDQGMPSHYVGVFTDISEIKASEARLQSLALFDSLTGLPNRRSIETGLGGALVRAKRRNRRVGVLFIDLDRFKTINDSLGHVAGDELLKAIAVRLGQRL
REEDTLARLGGDEFLLVVDSLTREDLGTVARSLLQVLEGPFVLATHEVYIGASIGVSLYPDDAADVTALIQHADAAMYQAKEQGRNTYRFYTRVLTQRAN
RRLDLETRLRRALEREEFLLHYQPIVSVDDGRVLGLEALVRWQPAGAPLMRPLEFIPICEETGLILPVGEWILRTACNQVRQWLDAGCVPFKMAVNLSGR
QLRYREVCRQIEGALRDTGIPADRLQLELTEGCFLAQGQEALAALGELESLGVELVIDDFGSGCSSLSHLKRFHVAQLKMDRGFVQNLVLESDDREIASA
IIAMAHVLGVEVVAEGVENEAQSEWLAQMGCDAVQGYLFGRPLTAEAAWQWVRRGG----
>tr|W6LS43|W6LS43_9GAMM Putative Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Candidatus Contendobacter odensis Run_B_J11 GN=BN874_1
----------------------------------------------------------------------EAEQALRESQERFRHLFEAHPLPMWVYDLT
LSFLAVNDAAIQHYGFSRDQFLNMT--IA--DIRPPEVPRLLDNIAQVQNHHIDEAGIWKHRKKDGSLIEVEITSHIL--EFAGRRAEVVLAHDVTERLR
AEERLRQAATVFENTREGITITDADERILRVNRAFCDLTGYTEAEVQGQTPRLLHSGRQTPAFYAAMWVSLRATGHWQGEIWNRRKDGKEFPELLSISAV
KNATGVVTHYVGVFTDLSSLKASEQRLDFLAHYDPLTGLPNRLLLSAQLQHGIDIARRDDEALALLVMDLDRFKDVNDSYGHSAGDALLQQVAERLTSRL
RSADTVTRLGGDEFAVLLENLVQQDAARVAMEIISLLSEPWQLANAELRLGASVGISLFPAHGHSAEELLQQADAALYQAKNEGRGRFQYFSADLTEATR
QRIELEARLRHAINDQQLRVYYQPQVDIATGRIVGAEALVRWQDPEQGLISPARFIPLAEETGLISVIGEWVLRETCRQGKVWLDAGLPPLTLAVNLSAR
QIHQGDIAATVMQILSDTGFPAEWLELELTESALMQRETEAVTILERLRGLGLHLAMDDFGTGYSSLAYLKRFPLDVLKIDKSFVDDIPHQRDDMEIAAT
IIAMGHILGFKVLAEGVETAEQLAFLQLKGCDQYQGYLTSPPVPADAFVTLLRNPI----
>tr|G4E2Y4|G4E2Y4_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodospira sibirica ATCC 700588 GN=ThisiDRAFT_0663 PE=4 SV=
-------------------------------------------------------------------------AALEKTTEELGYIIQHDPNAIAVHDKE
LRYIYVSERYLQDYKVEQTQLI--GYRHY--EVFPDIRRALAGEVLRCEED--------RFERADGHVEWTRWFDQHQ--QIGG---IILYTEVITERKQ
AEMALRQAACVFESTRDGVLITDLNARIVAVNRAYTEITGYHEHESLGQTPHILNAQHHPPGFYTQLWQCLQAQGHWQGEIWNRRKNGELYPQWLTISTV
YNEARQPTHYVGVFTDISQLKQSEARLEHMAHYDPLTNLPNRVLVQSRLQHAIEQAKREKQQLAVLFIDLDRFKNVNDSLGHPTGDALLVAITQRISARL
READTLARLGGDEFLLLMEGVPHRDAGRVAQLVLDLLEKPFLLNDHEIYVGASIGISVYPDDAHSVTHLIQHADAAMYQAKAQGRNTYRFYTRTLTEAAD
RRLRLENQLRRAVEHGEFELYYQPIVCASTHQLHALEALLRWHPVDAPPIPPSEFIPLCEENGLILPLGQWVLQHACTQAKHWLAAGSVPFRLAVNLSAC
QLRIKEIPQQIAQTLEHSQLPADCLELELTESAIMEQGSEAIHLLQEFKAQGLHIAIDDFGTGYSSLAYLKRFAVDTLKIDRQFVMHLTEDQSDYEIVTT
IVAMARNLRLNVVAEGVETEAQIKALEAIGCDALQGYAFSRPLPAAAIHSLLFPAN----
>tr|D5CN45|D5CN45_SIDLE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sideroxydans lithotrophicus (strain ES-1) GN=Slit_2517 PE=4 SV=
----------------------------------------------------------------------QAETALRDSEDRF--IFNNAIDGILLADST
RKFIMGNSAIARMLGYSNEELLQLG--TE--DIHPEQKEYYIAQFAMMVRGESTLSSNAVVKRKDGSVFYADIKASPL--RIGDKVYLMGFFRDITERKQ
TEDALRQGAAVFESSHNGIIITDLDGHILAANQAYADISGYTESELLGQNPRILNSGRQSRDFYRKMWANIKEAGSWQGELWNRRKNGEIYPTWLAVSAV
RNDQGKATHYVGISSDLSQLRQTEAEREHLAHYDPLTDLPNRLLLRSHLTHALAQAKRHHNQVGVLYLDLDRFKNINDSLGYQVGDELLVTLTERLTMHM
RSEDLLARLGGDEFLLVLEHINEEDSAIVARSLLETLAQPFVLHGREIFIGASIGISIFPNDGDSAEQLIQHADAAMHQAKTLGRNTYHFYTEDLSRASN
EHLELENRLRHAITANQLRVYYQPQVDIATGHIIGAEALVRWQDPERGLVQPGQFIPLAEETGLIGAIGEWVLKETCLQGMRWIDAGLPFLTLAVNLSPH
QFLRGNIAGLISKVLAETGFPADRLELELTESALMQQGEDVIKMLHLLRAQDIRLAIDDFGTGYSSLSYLKRFPLDILKIDKSFVDDIPFHQDDMEIAAT
IIAMGHILGFKVLAEGVETREQLEFLQARGCDLYQGYLTSPPIPAEEFEKLLKENM----
>tr|H1G534|H1G534_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Ectothiorhodospira sp. PHS-1 GN=ECTPHS_09537 PE=4 SV=1
-------------------------------------------------------------------------QKARQQERKYQMASTLARLGSWQADLN
GKV-YWSDEVCRIHDMPPGTTIALEDGIR--FYAP-ERPRIIEVFRACAEAGTPYDEELQIQTAKGRRLWIRTRDE-----KGNIIRVQGAFQDITERKQ
AEERLQQSATVFEATSEGVIITDAGTRILAVNRAFTKITGYSEEEALGRNPSLLSSGRHSQSFYEQMWASLHNAGHWRGEIWNRRKNGEVYPQWATINAV
HGDNGTITHYVAVFSDISDIKRTQEEIQRLAYRDPLTNLPNRLLFRTRLEQALLRAESRHSDLAVLQLDLDEFKHINDSLGHSEGDQILSEVADRLETVL
QKDETLARMGGDEFAILVEDSSKRRPEIVAESVLQALQAPIQLRNQEVFVTASIGIATYPHDGQDVEQLLQHSDAATYRAKHAGGNTYRYYAQDLTEYAR
DRVVMATELRHAIQRNELILHYQPQVDLSTGEIHGLEVLVRWEHPSQGLIPPNRFIPMAEDTGLILPLGRWVLEQACRQALHWDREGLVFGRIAVNVSGI
QIQRSNMVETVATVLQDTGLDSRLLELEVTESFIMDRRQGAHELLEALKALGVTLAVDDFGTGYSSLSYLKSLPFDCLKIDQSFIRGIPEDTHDLAIAKA
IITLGTNLGFQVLAEGVETESQRDLLTDLGCHQAQGYLFSRPLPAHQIHEFLRERP----
>tr|G8QPP4|G8QPP4_AZOSU PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Azospira oryzae (strain ATCC BAA-33 / DSM 13638 / PS)
--------------------------------------------------------------------------AMQFKPHRFQNILENLPDGVSLYDPQ
-RMIACNERFRTLLDLPDTL-FAQGYPTLEGEYGPGDERRTRGVLRALQR---PNNTAVLRERPDGTVLEIRQ----V--NLGD-GSTIIIYTDITARHR
AEAELKLAEKVFANSPEAIMICDQGNRIISVNRAFCDITGYAQEEVLGQDPRMLASGRHDKDFYRQMWEILRDTGAWAGEIWDRRKNGEIYPKWMTINAV
HDTSGALTHYITLFSDITERKETEARIHHLAHHDPLTGLPNRFTLEARLEQSLADARRHGHKVAVMFMDLDRFKTINDSLGHAVGDSLLMEIAHRLRSAV
RESDTVARLGGDEFVVVLPDVEGNDAAHVAGKIIEDVARSLRVGAHELHTSASIGISLYPDDGETVPTVMQNADTAMYHAKAIGRNNFQFFASAMNRAAT
ERLELERKLRQAMVNDELELHFQPQFALAADRVTGVEALLRWRHPEDGLIPPDRFIPIAEETGLIVGIGDWVLQAACRQLKAWLDQGLPPLRMAVNLSTR
QLKEKEFPSRVAAILQETGLPAVLLELEITESGVMERPEEAITTLQALNDMGVTLAIDDFGTGYSSLSYLKLFPIDRLKIDRSFVRDIERDPDDAAIARG
TIALAHSLGLEVVAEGVETSAQLDMLAADGCDEVQGYFFSRPLPLAAATAFLAQQA----
>tr|W8KHX3|W8KHX3_HALHR Uncharacterized protein OS=Halorhodospira halochloris str. A GN=M911_09810 PE=4 SV=1
-------------------------------------------------------------------------ASARERSIKFQMAGTLARMGGWMADLS
ETV-EWSDEVCRIHDLEPGSGVSIEQALA--FYMP-GRRRMEEVFRRCANMGEPFDEEMRICTARGREIWVRAQGE-----GGRITHVQGAFQDITDRKR
AEESLRQWSTVFRATSEGVMITDAKGEILAVNQAFTHITGYEQHEVTGKNPRVLKSGRHQPLFYRRLWDAISLSGFWRGELWNRRKSGAIYPQWTVINAV
RDESGVLSHFIGVFSDVSDLKDSQDQIERLAHRDPLTNLPNRLLFRTRLEQALASAKRQSGGLSVLLVDLDGFKHINDSLGIRVGDELLYEVAERFGSVM
KDDEVLARLGSDEFAVMVPGENGQRADLVAEAIRQVVEAPVRIADRDIFITTSIGIASFPRDAHDAEELMQFSDAAMHHAKEQGGNVYFHYTEDLTDHAR
DRVTLSSELRHALDSNQLLLHFQPQVDLIDGSVVGLEALVRWRHPEQGMIPPNRFIPIAEETGLILPLGRWVLRQACLQARHWAAQGLEFGTIAVNVSGI
QVQRSDMVQTVADALQESGLDSSLLELEVTESFVMDRRQGPSAFLGELKAMGVQLAVDDFGTGYSSLSYLKDLPFDVLKIDQSFIRGLPENQRDMAIARA
VNTLGAHLGMEVLAEGVETTEHQEALLDMGCHRAQGYLFSRPVPAEEIPAILRARC----
>tr|Q31GH8|Q31GH8_THICR Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Thiomicrospira crunogena (strain XCL-2) GN=Tcr_1150 PE=
----------------------------------------------------------------------IIEASRQEALDRL-YQF-------RLMPDT
SSFPFASDALYEIYRVKPEDVTEDSSKVFE-VIHPEDVDDVQKSIEESAEHLTPWYQEYRVRFKNDDVRWLSGKQP------DGSILWHGFITDISQHKK
TEAQIELASKVFEQSREGIMITDSNQKILMVNEAFSEISGYSVEETLGKTPRMLASGRHSREFYQNVWKSIKEKGHWQGEIWNRRKNGEIFPEWLSISRG
LDTSGNVTEYVGIFNDISKVKESEEKIKHLAHYDPLTGLVNRELLMDRLNHSISTADRNNTPLALLFIDLDHFKNVNDTLGHQVGDQLLIEVGQRILKIL
RDEDTIARQGGDEFIVVLPDTGEG-AVHVAEKILESISDQLNLKPYKLFITPSIGIAVYPQDGKDADSLLKNADTAMYQAKNDGRNVYRFFTMEMQAHSS
RIMQIESALRVALFDQQFELYYQPQTCAKSGSIIGVEALIRWNHPEMGPVSPQEFIPVAEQSGQILAIGWWVLRTAIRQIKIWSEHGKPCIKVAVNLSAV
QFRYEDLPKQVMKILEEEGVSPEFLELELTESVAMANPEAVIEMMDKLVGHGIKMSIDDFGTGYSSLSYLKRFKVSKLKIDQSFIRDLAVDSDDRSIIEA
IISLSKALGLKTIAEGVETQAQLDFLQEKQCDEIQGFYYSKALTPEAFDAFYEKQS----
>tr|A0A066ZNL3|A0A066ZNL3_HYDMR Uncharacterized protein OS=Hydrogenovibrio marinus GN=EI16_01950 PE=4 SV=1
----------------------------------------------------------------------VIEHERQEALERL-YQF-------QLYKNR
SCFPFASEAMEHIFRVKPESIFEDATAVFD-RVYPDDLEGLNLSIQESAENLASWQYEFRLIFDDGEIKWLSGKQS------DDSILWHGFITDITERRK
TEEQIEMASKVFEQSREGIMITDANLKLLMVNDAFSDITGYSREEVLGSAPSVLSSGKHTKEFYSQMWKQIEGEGHWQGEIWNKHKSGRFYPEWLSISQG
KNKDGEVMQYIGVFTDISKMKESEEHIHRLEHFDSLTNLVNRESLIKRLTKAISQAEENHKNVAVLFIDLDHFKNINDTLGHYVGDKMLMEVGRRISDLL
GAEDQLGRQGGDEFIAVMPNADEE-AAHMAENVLKSVAFEMSLENLNLQITPSVGIAIYPQDGSDAGSLLKNADTAMYQAKSDGRNNYRFFTHEMQQHAA
KIMSIESALRTALVRNEFEMYYQPQVCAHTHKVVGAEALIRWDNPELGRISPTEFIPVAEQSGQILDISNWVMETAIEQIKEWQERGLPFVNIAVNLSAA
QFRDEALPSQIIGLLNKYKVDPSCLTVELTETLAMSNPHSAVQIMDKLTSHGVRIAIDDFGTGYSSLSYLKKFKATKLKLDQSFVRDVVEDADDRSIIIG
MISLAQSLGLKTIAEGVETQYQLSFLEEKGCDEIQGYYFSKPIPSDEFAQFISERK----
>tr|C3X2S1|C3X2S1_OXAFO Diguanylate cyclase (GGDEF) domain-containing protein OS=Oxalobacter formigenes HOxBLS GN=OFAG_00660 PE=4 SV=2
----------------------------------------------------------------------KA-------ENEL----ED--KPVWVQDF-
-----DSDPICDILRN--------STIWK---------------------------------DVTKENQIHAIHKNGK--TIAAQKLLKELVTSILDNFD
RKQQLQLSAQIFTQSNEGLMLLDSACHIVMVNKAFTTITGYSDTEALGHNPRILSSGRHDRDFYENMWNRIDKHGSWQGEIWNRRKDGTFYPEWLSIQTM
RDSFGKLTHYIGLFADMTERKKTEEKVQWLAHFDALTGLPNRTLLRDRSNLAISLAQRRHEPLALMFLDLDGFKNVNDSLGHNTGDELLKQFASRLKSVV
REQDTVSRQGGDEFVLVLPNTDTG-ATSIAEKLLAIAAEPYHIEPHELNLTASIGIAMYPADGIDFDTLSCSADTAMYRTKQGGRNNYCFFTTEMQARSA
RMLELDSALRRALEREQFTLHYQPIMSLKHHIIVGFEALLRWEHPQLGPVSPEEFIPVAESNGQIIPIGEWILRSVISQLRKWIDAGHEEIMVSVNLSAI
QFRDRRLSDMVSTLLKEAQVSPDRLVLELTEGVAMEKPDAAIVVVDSLKERGVKVSVDDFGTGYSSLAYLKRFSAHSLKIDGSFIRNIPDDTENMAIVSA
IVSLAKNLGIKTIAEGVETEEHIAFLTEIGCTAIQGHYLSRPMTADAASDFLNAAL----
>tr|C3X2S2|C3X2S2_OXAFO Diguanylate cyclase (GGDEF) domain-containing protein OS=Oxalobacter formigenes HOxBLS GN=OFAG_00661 PE=4 SV=2
----------------------------------------------------------------------QTQKELEESENNY----EN--KPIWMQDF-
-----LHEPAMK--------------HWQ---------------------------------KHIEHFKWRSSHRNGN--VISSQRLLLELVEDILEHFE
KEEQLQLSAQIFAQSSEGIMLLDPNCHIVMVNSAFTHITGYSEEETLGRNPKMLASGQHDRNFYATMWEAIETEGRWQGEVWNRRKDGSLYPEWLLIQTM
RDSRGTLTHYIGTFTDLTERKETEERVQWLAHFDPLTGLPNRTLLHIRSNLAISLAQRRHEPLALMFLDLDNFKNVNDSLGHGVGDELLKQFSQRLVNAV
REQDTISRLGGDEFVLVLPGTDTG-AAYLAERLLNIAARQYNIERHEINLTVSIGIAMYPTDGTDFDTLWRSADAAMYRAKQSGRNDYCFFTTEMQARSA
RTLQIDNALRRALERNQFSLVYQPQLSLNTNRIVGFEALIRWTHPQFGNTPPDEFIPIAESNGQIIPIGEWVLKTAVRQLRLWQDNGLKDVTISVNLSAV
QFRHPRLPELVMAILEEAGVSPECLQLELTEGVAMENPLAAITVIDELRKKGIRISIDDFGTGYSSLTYLKRFNVYSLKIDRSFVQDLPNDTEDMAIVSA
VISLADSLGMITVAEGVETKEQLEFLRSRGCTEIQGYYLSRPLQADAVFSFIEDDH----
>tr|Q607T2|Q607T2_METCA Sensory box protein/GGDEF domain protein OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN=MCA1673 PE=4 S
----------------------------------------------------------------------RSEMRLRESEERF------APVLIWMGDTR
GCT-FFNDMWLNFTGRSLEYEL--GDGWLE-GMHPEDRSRWICAYSAAFDARKPFEIEYRLRRRDGEYRTILGFDA-----GGEFIGYIGSCIDISDRKK
GDESLLLAGKVFEAVRESIIVTDANRVIVAVNPAFSDMTGYSPEEAVGRTPAFLQSGRHGKEYYAAMWRAVDQEGSWQGEFWNRRKNGELFAVLETIVTV
RDETGAMVNYIGVAADISSLKEAEEHIHHLAYYDPLSALPNRRYLMERAEYALALAERRKEELAVVFLDVDHFKDVNDSLGHQVGDELLVRVATQIKEFT
RETDTVARLGGDEFALLLPDLGRA-VSQVADKILAALRKPFEHSGQTFAVTGSIGISLYPHDGTDFETLLRNADTAMYHAKQQGRNQFRFYDPGMNVDIL
ARLTVLSELREAIPAGELRTFFQPEIDLANGTLVGAEALVRWQHPTRGLLSPDQFIPVAESNDLIIAISDWVLEDTCRHLAQWKKADQAPITVGVNLAAR
HFRDPRLVPRVKSLLCRYGVPGSSLQLELTESTLLDADAQTMIVLQELIALGCSLSIDDFGTGYSSLSYLKNLPIATLKIDQSFVRDIAFDADDRTISGT
VVALGHSLGLKVIAEGVETEEQRRILLEQGCDFGQGYLFSRPLSSKEFIKWRMEHA----
>tr|Q3SIW6|Q3SIW6_THIDA Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Thiobacillus denitrificans (stra
-----------------------------------------------------------------------------------KEAQRIAQVGSWALDLT
GKL-IWSDEMFRIFETDEAAFG-QSYEAFLDALHPEDREHVNKAYMHSVTNHTPYDLVHRLLLPDGRVKWLHGYGK-----NGDPIASCGTVQDITARKK
QEDALRLYASIFEHSGEAILIADQARHIIAVNPAFTNLTGYALDDIRGEEPTILAGGQASEESYRSTWASLEQTGYWQGEIIDRRKDGTLYPKWMAVSVV
RDADGVLTHYVASFTDITERKLAEAQIKHLAYHDPLTGLSNRFSLQTQLDQTLALARREQRTLAVVFLDLDRFKSINDSLGHALGDQLLVEVARRLRDNV
RDSDIVARLGGDEFVVVLTEVGDAGAARVADKLLGALVPRYRIGGHALHTTASIGISLYPHDGDDADALMKNADTAMYHAKSQGRDNVQFFTPEMNQSVL
KRLQFDHDLRVAVEAGQFELHYQPQINSTSGRVVKVEALVRWQHPREGLVSPAEFIPIAEETGLILPLGEWVLNEACRQLRLWRDAGITDLTVAVNLSAH
QLHSPALIPMVARTLGNHGLEGADLCLEITESVAMRDTTASIAQLQALRDLGIHLSIDDFGTGYSSLSYLKLLPIDTLKLDQSFVCEIEFNPSDVAICAA
TIALAHSLGLEVVAEGIETETQRRLLASHRCDFMQGYLFSAPLPAERALAYIREQQ----
>tr|G2E5N9|G2E5N9_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_3602 PE=4 SV=
----------------------------------------------------------------------QAEAALRR----FRTVGEAIPYGVWTTDPG
RCT-YASQSFLEMVGMTLQEVQ--EFGWL--HLLPPEVEPTKTHWLRCIQSGEDFEQEHHFRDRDGAWRHVLAHDG------AAIESWVGINLDITARKD
MEEALREAHDILQGMTEGLVIATPEGMVLDMNPAAQRLHGFTHQGELAEFPNIFEGELQPPESWPL-SRACRGEIFSHHELWVRRHDGQSFIGSYGGTPV
RDVTGRLRLGIVTIHDITEQKRAEERIRQLAFYDPLTGLPNRRLLEERLATALTRAKRQQECLAVIVLDLDFFKQINDSLGHAAGDALLVEVARRMSACV
RTVDTVARPGGDEFMLILPETGTG-TAHLAAKLIARLNAPLHLEGQELSISCSLGISLFPDHGTEASTLISCADTAMYRAKQSGRNRYQFFTEDMQREAR
RAITLEQQLRAVLAGEGLCLHYQPQVTLASGRAIGLEALVRWAHPTHGLLGADAFVPLAERNGLIEDLGAWVLRAVGAQLSAWSRARLPLLPVAVNLSAQ
QFRHSALIAQLNTLLADGTLDPSLIELEITENSLLEETDETLETLQALRTLGVRLTLDDFGTGYSSLHYLNAFPVCCLKIDQSFVRAAPEQPRQAAIVQT
ILALGRHLDFSVIAEGVETAAQLTQLRRLGCEQAQGYYFSRPLPAREVEEWLRRAV----
>tr|W0E354|W0E354_MARPU Diguanylate cyclase OS=Marichromatium purpuratum 984 GN=MARPU_08825 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------AEHGSACFEWLHR-RRDGSRELESGQLRVAIIRDLSEQRR
REDILRLTNAVFENTAEGIIVTDADGEIVAVNPAFSEITGYTPEQVRGRNPRLLKSGRQGPDFYRQLWRALLDQGRWQGELWNRRCNGELYPQWMSINAI
RNHHGRVANYVAIFSDITERYRSAEEIEYLSNHDPLTGLPNARLLKQRLAQAVDLAALHRQRLGVFYVDIDRYNDVIASYGHGVADTVLCVLGERLSEAT
GVGDLVARLSDDTFVILTELGEEATASAFAAHYLAICCQPIEIGHGQLTLSASAGGALYPGDGEDAAELLRNAASALLSAKRCGRRSIAFYRPEITAAAV
ERLALEEALRIALAEEQFVVHYQPLVEPQQNGIHAAEALLRWRRGA-QLVMPGVFIDIIESSDLVVPVGRWVIEAVLRQMRLWRDAGLPEIRVSVNVSEP
QITAGGLTETIADLLERYDIPARLLHIELIERVLLHDPERALAELERLRALGIGISLDDFGTGYSSLSYLIHFPVDFIKIDRSFVNDLATDGRSRAIVRA
ILSMARNLDIGTVAEGVEDIRQQRILTAEGCDLIQGYLISRPVSANTLTRMLEAQ-----
>tr|D9SHH9|D9SHH9_GALCS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Gallionella capsiferriformans (strain ES-2) GN=Galf_1970 PE=4 S
----------------------------------------------------------------------------------------------------
------------------------------------------------------------DITPSGAILWEEV-----S-DAGHLLGLRGTGRNITGRKL
KEEQLRVAAAAFE-THEAIMITDAHGTIIKVNQAFQRITGYSQEEVLGENPRILSAGRNEKSFYSAMWQQLTTLGRWRGEIWDKRKSGQIYPKWMTITAV
RDENGKTTEYVAIFSDITQRKLAEEEIRNLAFYDALTRLPNRRLLLDRLHAALSVSARSRRFGAVLFLDMDRFKTLNDTMGHDYGDLLLIEVAERIKLCV
REIDTVARLGGDEFVILVEEIDTAEIAAIAEKIRSALSVPYRLKEKHHHSSPSIGVCLYRGIEESTDDLLKHADMAMYQAKDSGRNAVRFFDPLMQQAVE
ARVTLENDLRHALPNDQLQLYYQIQVDND-RRAIGAEALVRWIHPIRGMVSPAHFIPIAEETSLILEVGAWVLKTACLQLAVWADRPMTCNILAVNVSVQ
QFKQVGFVEHIAELIRAYCIVPQRLKLELTESVVLNDVSDIVQKMCALKSLGVRLSMDDFGTGYSSLSYLKNLPLDQLKIDQSFVRNIATDENDAVMVKT
IIAMAQNFRLNVIAEGVETEAQLAFLKQNGCMCYQGYYFGKPAPIEQFQSQLEAL-----
>tr|S6AKY6|S6AKY6_9PROT Uncharacterized protein OS=Sulfuricella denitrificans skB26 GN=SCD_n01413 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------GH--DVWM-R-----CRTSRGEPHLLLMLENITEKKA
AEEELRLAASVYQNSSEGILVTDVTGIILSVNPAFTEITGYTEDEALGKKTTLLRSDRHGPEFYRSMWEALTKEGCWRGEIWNRRKDGEVYLEWLSINRI
EASAGAPFRYVAVFHDITELRRKDEEIRHQAFHDTLTGLPNRALMKDRLLHALERAKREGGRLSVIFIDLDRFKAINDGLGHDVGDLLLQEVARRIKIRM
RTVDTVARLGGDEFVVLMEDLRDGDCASLAQELIAEIARPMKLSGHAVEISASMGMAFYPEDGANPLELMKCADLAMYAAKSAGRNTYRFFQQDMQDRIS
QRLTLEMELRLALVQRDLELHYQPKVDLATGNILGVEALLRWWHPLRGLLLPADFIPLAEECGLICELGDWVLDEVCHQSAVWQAAGHTF-KIAFNISPH
QLETGDLVARISELTALHGIAPSDLEIELTESAVMAYSIQAASVLARLRGIGVTVAVSDFCAGYSSLAYLRKLPIDILKINHSFVTDADSNAEDAQIVKT
ILALGRMFKLTMEAEGIETSHQAELLKSFGCGIAQGYFFSRPLPAQEFENWLDAK-----
>tr|K9SGK2|K9SGK2_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudanabaena sp. PCC 7367 GN=Pse7367_0816 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------KTAAGEDPTWLDV------IDSDGVIGILSTVEDIT----
-QAALAKYRNIFENAVEGIFQSDREGQYISANPALAKIYGYDCAEDLLVAIRDQIYVEPE--RRDEF-INQLRSGVF-------CRDGTIIWVSENATAV
HDAEGKLLYFEGIVEDITERLRAEERIRYQAAHDLLTELPNRKLFNQRLREAIGRAK-EGSLMAVMFLDLDRFKTINSSLGHGAGDQLLQEVAQRLKDSL
APTITLARWGGDEFTLLLPIVASEDAVAVAEQILNQLKPAFC-ESCTIHSSCSIGIAIYPKDGEDGSTLIKNADAAMFSAKEQGRNNSQLYARAMNIDAT
SLLELESGLHTALEAGEFVLLYQPKVNPEKSTIVGVEALIRWQHPAMGLIMPNVFVPLAEENGFILPLAEWVLYAACKQNKIWQEQGIATMRVAVNISAR
QFLQPTLVDTVAKILNQTGLEPQYLELEITESLAMQDVYLTRTILDELYDMGVYISIDDFGTGHSSLSSIKNFPVHSLKVDQSFVRDLPEDRHSRAIIAS
IVALAQGLNLKVVVEGVETEAQLNYLRSLHCEEIQGHLYSKPISAQKLIDLIAA------
>tr|A0A0D6AEW9|A0A0D6AEW9_9CHRO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Geminocystis sp. NIES-3708 GN=GM3708_1738 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------F-TKDNQEKWVWE------IDRQGLLGIEGLITDIS----
-EEALSKYRNFFENAIEGIFQTE--GYYLSANKALAKIYGYDTPLQLIENIEKSLYLQPK--RRQEF-IQLLKNEAF-------KRDGSIIWISENARAV
RNTQGNLLYYEGTVEDITKYKEAQEKLHYQAFYDSLTQLPNRTNFLQKLSNSIANLIENSYQFSVLFLDCDRFKAVNDSLGHGIGDLLLIAIGERLQNCV
AEKDFVARLGGDEFTILCDEVTEKEIIKLAEKINTAFQPPFI-NQYQLFCGVSIGIFFSSSIFLNPAQILQYADTALYKAKSQKRGYYQVFQGEMCNEAL
AELELENEIRQGLIEEEFLLYYQPIVDIYSGEIKGFESLIRWNHPQKGLITPNHFLNLAEETGLIIPIGFSVLKQACHQLKQWQEIFKKLPVLSINLSCQ
EFNTENFLTQLDSILEETGINPEYIKLEITESCSIFQEDFNIDILHQIVARKIQLWVDDFGTGYSSLSYLHKLPINGLKLDRFFIIDIEKDLAKAKIVKA
ILSLAQDLNLEVIAEGIESKTQLKILEEIGCKLGQGYLFSRPLSAENAYNFFHYP-----
>tr|A0A023X464|A0A023X464_9ACTN GGDEF: diguanylate cyclase (GGDEF) domain OS=Rubrobacter radiotolerans GN=RradSPS_1835 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------LRHRDGSWLHLEAIGKN-DDPAVGGVVVNARDVTERRR
AEQALDHLKSVTS--AAPIILFDREGTITLARGRGLEALGIK-DDLVGQQ--IFEVYREFPAVLENVQR------ALAGEEVARTVEIGSFFFDARYSPV
RDERGEVTGVIGVATDITERQKLERELEHRAFHDPLTGLANRALCMDRIEHALERARRRNAPVTLLFMDLDDFKVVNDSLGHTTGDELLVEVASRLRACV
RPGDTLARLGGDEFVVLLEETDLG-AVRVTERISDALGAPFYLEARQRFVNVSVGITVARPSGQRAGDLLREADLAMYRAKEDGKAGYKVFDAEMGTRTL
RRVELESDLRRGLENGEFELHYQPVVSLPEGRITGFEALVRWRHPERGLVSPAEFIGLMEKTGLIVPLGRWVLEEACRDLKRWQDARPERWEVCVNLSAR
QFRSPRLYSEVARTVERAGVRPETVNLEITESVAMSGATE-RETLKRLRELGVGLKIDDFGTGQSSLAYLKHLPVDALKICRIFAKDLARSATDREIVGA
IVRLGHALGLRVIAEGVETPEQLEVFRQLGCDLAQGYLFSRPVPAADVLGLLAGN-----
>tr|Q1ASD1|Q1ASD1_RUBXD Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129)
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------GRQTYRGRRVRITAMRDVTERKR
AERELEQYRRLVEQLPAVVYIDDETSSNVYSSPQTEKIFGYSPQEWASDPPRVLHPADR-ESVLAAHARANARGEPLELEYRLIARDGRVVWVRDSSIVL
RDAEGNPRWRQGLMVDITEQKNLEARLVHLAFHDPLTGLPNRALFMDRLEHALARAGRSGDVLAVLFIDLDNFKFVNDSLGHEAGDRLLALVARRLSGAT
RPGDTVARLGGDEFTVLLEGIADGEAARVAGRVAEVLREPFRVAGRELFVSASVGISVSTAGSGSVEELMRGADLAMYEAKREGKDRYRVFDFGMSRTAH
DRLRLENDLRRAVGRDELRLYYQPVVRLGDGRVVAFEALLRWEHPRRGILLPDRFVPLAEETGMIVGIGRRVLELACSRAAGWRRQEPSL-AVSVNISAR
QLVRPDFVEEVGRILQRTGLEPEGLVLEVTESAAMDEPGEAARALQRLRERGVRLALDDFGTGYSSLSYLRRLPVCFLKIDRSFVEGLGGDSGSGVLVGG
VIALSRELGFEPVAEGIETPGQLERLLELGCELGQGYYFASPMPEGAAGELVRSG-----
>tr|A0A0D6AMD4|A0A0D6AMD4_9CHRO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Geminocystis sp. NIES-3709 GN=GM3709_768 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------F-TKDNQEKWVWE------ISREGLLGIEGWITDIS----
-EEALSRYRHFFENAIEGIFQTD--GYYLNANKALARIYGYDTPLQLIENIENRLYVQPD--RRKEF-IQLLQNEAF-------RRDGGIIWISENARAV
RNIQGDLLYYEGTVEDITKYREAQEKLHRQAFYDNLTQLPNRTLFLQHLSNSIHKLREFSYQFSVLFLDCDRFKAVNDSLGHGVGDLLLIAIGERLQNCL
GEKDIVARLGGDEFTILCDEVTDKQVVKLAEQINSVFQPPFV-NKHKLFCGVSIGIFFSSSVHLTSSQVLQYADTALYKAKSQRRGYYQVFQGEMHNEAL
AELQLENEIRQGLIEEEFCLYYQPIMEIYSGQIKGFESLIRWNHPQKGLVTPNQFINLAEQTGLIVPMGFGVLKQACKQLKQWHQLGLELPILSVNLSCQ
EFNVENFLTTLDKTFEETGLDPKYIKLEITESCCIFQEEFTLDILQQIIDRKIQLWIDDFGTGYSSLSYLHKLPIHGLKLDRFFTSNLEENPNKIKIVKA
ILSLAEDLGLEVIAEGIETKKQLIILEEIGCKLGQGYLFSRPLCPENAFDFFHHP-----
>tr|Q3A4W5|Q3A4W5_PELCD Response receiver sensor diguanylate cyclase/phosphodiesterase, PAS, GAF, PAS, PAS and PAS domain-containing OS=Pelobacter carb
----------------------------------------------------------------------------------------------------
------------------------------------------------------------FYKKDGSIVWVRDIIRIES-DAENKLCLHGLLIDITDSKQ
SESQLKKLSRAIEQSPVSVVITDPEGRIEYVNPKFTQLTGYTLEEVIAQNPRILKSGNLLPSVYDSLWKTITSGKEWYGELENKRKDGSIFWESASISPL
FDESGKIINFIGVKEDITQRKLNEKRLEYMATHDGLTGLANRTLLYDHLEIALHQSQRSKKLVAVILLDLDRFKVINDSLGHLVGDQVLKAVGQRLKQYV
RSTDTVARLGGDEFVVLLTDVRDTAAGKIAHNLLRKLNEPFFLHGRELYVSASFGICLSETDNVDGTILLRNADIAMYKAKAEGCGL-YFYSHEMNEHLI
KTLEMENSLRQALEKNEFQLYYQPKVEHATGRIIGCEALLRWRHPQRGMIPPSEFIPLAEETGLIVQIGHWVLAEACRQSKIWETEGLPPLTMAVNISAR
QFYQGNLIQAVKSTLERSQLVPSQLELELTESMVMKDAVNAERTMRKIKQLGVSLSLDDFGTGYSSLNYLRSFPVDSLKIDRSFILDIASDASSAAILNS
IIAIAHTLGLQTVAEGVENNDQLALVANCGCNYIQGYLFSRPLPPEDFVALFLAN-----
>tr|W0H4I4|W0H4I4_PSECI PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Pseudomonas cichorii JBC1 GN=PCH70_05990 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------IRHLDGQVRLCEMSSHPL----IAEECIMTLARDITKL--
-----HLAATVFESTAEGVLITR--QRINAVNRAFSEITGYGEDEALGQTPRLLASGQHDSAFYAAMWHQLSAEGHWQGEICNRRKNGELYPCWLTISAV
RNKDRFITHFVAVFADISSLKHAQARLDYQAHHDPLTGLPNRTLFENRLHSALLHSEES-SLGAVLFIDLDRFKHINDSLGHPVGDLLLKGIAQRLKETL
RDIDTVARLGGDEFIVLLPGLLQGDAQTIGSKLLACFTAPFQAGEHEFFMSASIGSCLFPTDGTDVATLVKNADAAMYRSKAKGRNRIESYTRDLTSQAS
ERIALEQELRRAIERNELSLSYQPKTSLLTNRLVGAEALIRWSHPTFGEVPPEHFIPLAEENGMILQIGDWVLEHACRQMYEWRKNYAPFGPLSVNLAGA
QLRQPNLLKRIEQLLADNGLEPGCLQLEITENFIMSQTEEALSVLHKLKKLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFVRGLPEDTHDAAIVRA
IIALGRSMQLTIIAEGVENPEQQKFLTEQGCEQIQGYIVSLPLPPEEFCSRFLLM-----
>tr|A0A059L4Q8|A0A059L4Q8_9PSED Diguanylate cyclase OS=Pseudomonas mandelii PD30 GN=V466_09640 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------IRRNDGQIRLCEVSSRPL----IGEDCMLTIARDITKL--
-----QQAATVFESTAEGVLITQ--QHISAVNRAFTEITGYSESEALGHTPRLLASGLHDSAFYAAMWHQLTAEGHWQGEISNRRKNGELYPSWLTISAV
RNRDKFVTHFVAVFADISSLKHAQAKLDYQAHHDPLTGLPNRTLFESRLLTALNNQQEN-GQGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAVRLKEQL
RDIDTVARLGGDEFIILLPGLQQSDADNIATKLLNCFSAPFQAGEHEFFISASIGTSLYPKDGCDVATLVKNADAAMYRSKAKGRNRVESYTRDLTAQAS
ERVALEHELRRAIERNELHLHYQPKISLVDHRLVGAEALIRWRHPTFGDVPPEHFIPLAEENGMILQIGDWVLETACRQMFEWNQVYEPVGPLSVNLAGA
QLRQPNLLGRIEQLLKDNRLKPGFLQLEITENFIMSQAEEALAVLHQLKHLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFVRGLPDDPHDAAIVRA
IIALGRSMQFTIIAEGVETLAQQHFLAAEGCEQIQGYIVSLPLSPEEFAATFLRI-----
>tr|A0A0D1NV72|A0A0D1NV72_PSEPU Pseudomonas putida strain UASWS0946 Contig186, whole genome shotgun sequence OS=Pseudomonas putida GN=QV12_22475 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------IRRADGQIRLCEVSARPL----IAVDCMLTIARDITKL--
-----QLAATVFENTAEGVLITD--QHISAVNRAFSEITGYSEFEALGQTPRLLASGQHDSAFYAALWHQLTAEGHWQGEIQNRRKSGELYPAWLTISAV
RNHEREITHFVAVFADISSLKHAQAELDYQAHHDPLTGLPNRTLFESRLQAALSSPQPS-RQGAVLFLDLDRFKHINDSLGHPVGDLLLKAIAQRLKEQV
RDNDTVARLGGDEFIILLPGLHQSDAEHIANKLLACFGAPFQAGEHEFFTSASIGTSLYPQDGTDVASLIRNADAAMYRSKAKGRNRVESYTRDLTAQAA
ERIALEHELRRAIERKELSLSYQPKFSLKTQSLVGAEALIRWRHPTFGDVPPEHFISLAEENGMILQLGDWVLEQACRQMQAWKHSYLAFGPLSVNLAGA
QLRQPLLVQRIEQLLRTHQLKAGDLQLEITENFIMSQAEEALAILHQLKRIGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFIRGLPDDPHDAAIARA
IIALGRSMQLTIIAEGVENQAQQQFLAAEGCEQIQGYIVSLPLAAPEFAATFLRR-----
>tr|U5VKU4|U5VKU4_9PSED PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. VLB120 GN=PVLB_23275 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------IRRSDGQIRLCELSARPL----IAVDCMLTIARDITKL--
-----QLAATVFENTAEGVLITD--QHISAVNRAFSEITGYSEVEALGQTPRLLASGQHDSAFYAAMWHQLTAEGHWQGEIYNKRKNGELYPGWLTISSV
RNSDGEITHFVAVFADISSLKHAQAKLDYQAHHDPLTGLPNRALFENRLQAVLSCAQVS-RQGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAQRLKEQV
RDVDTVARLGGDEFIILLPGLHKSDASAIANKLLACFSAPFQAGEHEFFTSASIGISLYPQDGTDVATLIRNADAAMYRSKAKGRNRVEAYTRDLTIQAS
ERIALEHELRRAIERNEMSLSFQPKFSLKTQSLVGAEALLRWSHPTFGEVPPEHFIHLAEENGTILQLGDWVLEQACRQMHAWKKRYSAFGPLSINLAGA
QLRHPGLAKRIESLLKTYQLKAGDLQLEITENFIMSQAEEALAVLHQLKQLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDKSFIRGLPDDPHDAAIARA
IIALGRSMQLTIIAEGVESQAQQRFLASEGCEQIQGYIVSLPLSPEEFAATFLRI-----
>tr|W0DVH2|W0DVH2_MARPU Diguanylate cyclase OS=Marichromatium purpuratum 984 GN=MARPU_00175 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------ERLIAWHHNLVRDGE---GTVIGTLSSGEDVTERRL
AERALAFLQHVIDGIDDPIMVIGTDHHVLRMNRVAQRLAAVDDAGLHEWGCHQLAPHPCPEDPLCPLRTILESGEPCKMLRHHRLPDGGVRQYEVAASPL
LDDTGEVIGIIEVSRDLDRLRERENSYAHLAHHDPLTGLPNRLLFADRLEQAIRLAHREHTRLAVLFIDLDGFKHVNDSFDHSYGDQVLKVVAGRLRAQF
REGDTLARMGGDEFTLILNGIAHDDAARVARAILQLFKDPFEVGEHSVFLGASIGISLYPEHGARAEDLVRNADAAMYRAKDEGRNGFRYYSEELTARAF
ERVLLESSLHRALERDELELFYQPQLDLVSGELRGLEALVRWRHPEMGLVSPGKFIPLAEESGIIIVMGEWILEHACTQMRAWQQGGLLDELISVNLSPK
QFDQHALSEMVGGILTRTGLSPAGLELEITESTMMRSIERTRHVLGALRALGVKIAIDDFGTGYSSLTQLKRLPLTKLKIDKSFVSDIPDDANDVAIAKA
IIALASSLSLEVLAEGVETREQQDFLTREGCHTGQGYLFSHPLEVAALERFLLAL-----
>tr|H2CD26|H2CD26_9LEPT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptonema illini DSM 21528 GN=Lepil_2832 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------AE-----VHLMRLSH---SGRDLLLFSVEDVTGRKA
AEDRLRLSAAVIASTRDGVIITDRDGLIVTVNHAFSEITGFSEEEAVGQNPRILQSGRHPKTFYQQMWHSLEEIGHWQGEIWNRRKNGEVYPQLSSLSAI
HDENGVIAYYVAVFTDISRLKEAEQRLEHLAYHDPLTDLPNRALLHLQMDHALEKARRRGTSLALHLIDLDRFKDVNDGYGHPAGDELLVAIAERLRKRL
RREDLLVRLGGDEFVILQEDLPEGAAAMLARMVIDTLSDPFSIGGRELYIGASIGIAIFPEDGEDGTTLLRNADAALYQAKGQGRNMFHYYTSSLTIAAA
EKLRLEGRMRRALELDQFLVYYQPQISLLGDGIIGAEALIRWIDPEKGSVSPGDFIPAAEECGLIGAIGDRVLEASIKQMRHWMDDGIHLEKLAINISPR
QFRLYDVPERIADLLHRYNVPADRIELEITESALMEHGERAGQALQTLKEIGIRLAIDDFGTGYSSLAYLKRFPIDALKIDRSFVMDIPGDESDAQIAQA
IIAMAQSLKLKVVAEGVETEAQLRFFRERSCDYAQGYLISPAIPADKFADFVRSY-----
>tr|D7DMZ7|D7DMZ7_METV0 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylotenera versatilis (strain 301) GN=M301_0552 PE=4
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------D-KVWWGNIIIERCPELGSLMAIGRSLGVAIQREN
AGKRLHQAKIAFDSASEGIMITDDKVRIVAINKGFTEITGYSEEEVLGKSPKILQSGNQDDRFYKDMWAILKKEERWHGEVFNKRKSGENYYEWLTITAV
KDNAGQVVNYVGVFADITDVKRSQNRLHELVNHDPLTGLPNRRLLNELLEHSIKRAERDNHKIALLFIDLDRFKAVNDTLGHQVGDKLLLEASRRISLSM
RDSDVVARLGGDEFVVMMDMISKSDASLVAKKIIHALQIEFNIDGHEIYISASVGISTFPKDCADVEGLIKAADIAMYQVKNKGKNNHCFYSDDLSKSAV
ERFTLEGQLRHALVRKQFEVYYQPQVSLITGEIIGAEALIRWNHPKLGLVSPATFIPMAEETGLIVQIGEWVLREAAHQIVRWHKAGHAIQWIAVNVSGV
QIMRSNFADTVYGILMETDCNPHMLELEITESTVMQNTEYVIDTFNRIKQLGLKLAIDDFGTGYSSLSNLKRLPLDKIKIDQSFVRDLPDDLDDAAIANA
IYAMAGSLGFSVIAEGVETQAQADFLSAMGCKEGQGYLYSKPVTATEFSKLLTK------
>tr|C6X9G9|C6X9G9_METGS Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylovorus glucosetrophus (strain SIP3-4) GN=Msip34_0
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------H-AHWWGVIMIERDSELGALMSIGRSFGVAIQRES
SDHRLHQAKIAFESTAEGIFITDDELRTIAINQGFTDITGYTEDDVLGNIPNVLEADLKKPEPHREIWKALTREGRWRGEFWNQRKNNEQYAEWVTLTAV
NNEEGKVINYVGVFADISEIKHSQSRLNELVNRDPLTGLPNRRLMHELLDHAIKYAEREQNEIALLFVDLDRFKAINDTLGHQMGDKLLFEVSQRIRAAV
RDSDAVARLGGDEFIVMMDVLREEDAAKVAKKIISSLQNEFLIDGRELFISASVGISVYPDDSLDVDGLIKAADIAMYQVKNKGKNNHCFYSADLSQNAV
ERFTLENQLRRALARDQFEVYYQAQVSLETGRIIGAESLIRWIHPELGVVSPAKFIPLAEETGLIIPIGEWVLRQSAMQVKEWHDQGFDIDWVSVNVSGV
QIQRSNFADTVYGILVETDCESHLLELEITESTVMHNTEYVIDVFDRIKHLGVRLAIDDFGTGYSSLSHLKRLPLDKIKIDQSFVRDLPNNSDDAAIATA
INAMAQSLGFTVIAEGVETRQQASFLKKIGCQQGQGYLYSRPVTASEFTALLRAE-----
>tr|Y0KF67|Y0KF67_9PROT PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Methylophilaceae bacterium 11 GN=Meth11DRAFT_0603 PE=
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------E-HQWWGNIIIERCSELGSLMAIGRSLSVAIQREH
TGRSLNLAKIAFDSASEGIMIIDTNGSIIGINKGFSDITGYSEEEILGATPIVFQQGKH------DLWKSLSSEGKWCGEVINHRKNGEEYHEWLTITVV
KNHEHQITNYVGVFADVTEVKQSQNKLYELVNHDPLTGLPNRRLINELLEHAIKRAERESRQIALLFIDLDRFKAINDSLGHPVGDQLLFEVSRRIKQSI
RESDVVGRLGGDEFIVMMDNLHDDDAAHKAKSILTALQSEFLIDNKELYISASIGISLYPDDGKDVDSVIKAADIAMYQVKNMGKNNYCYYTKKHSADVL
ERFNLENQLRRALERQQFEVYYQPQVSLQTGEIIGAEALVRWNHPEYGLVSPAKFIPLAEETGIILQIGEWVLTQAAMRAKEWIDGSNSLKRIAVNVSGI
QIMQSNFADTVYGVLIHSDCVPSMLELEITESTVMQNTEHVISTFDRIKSLGVRLAIDDFGTGYSSLSNLKRLPLDKLKIDRSFVRDLPDDLDDAAIASA
IYAMANSLGFSVIAEGVETAEQVQFLRKMGCIEAQGYLYSKPITADEFSLLINKN-----
>tr|A0A011QJM1|A0A011QJM1_9PROT Bacteriophytochrome cph2 OS=Candidatus Accumulibacter sp. BA-92 GN=cph2_5 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------QVLRADGEGSGEAAGGLVGIMLDVTDRKR
MEQRLQQAATVFDSSAEGITITSPEGEIIAVNRAFSEITGYCEADVVGVNPRILQSGLQDPDFYREMWRTLRTCGRWRGELWNRRKDGQAFLESLTISAV
EDAQGCVTHYVGVFSDITELRKAHDQLDHQAHHDPLTGLPNRLLLGDRLHKALQRAHRDERGLAVLFVDLDRFKNINDTLGHQVGDRVLCEVARRLTRLR
READTVGRLGGDEFLIIIEDLADAAVSHIADKILSLLQDSPVTVEQEFYVGASIGISLFPQDGGDAETLMKNADVAMYRAKERGRNTYEFFTKELTQSSL
ARLQMETDLRRAIDRGELRVFLQPQFSLRSGELVGAEALVRWLRPELGLVMPGEFIKLAEESGLIVPIGEWVQQTAAGQWAAWVNEGRQPGVLSINVSGI
EFRRGRIQETARKTLDASCLAPQFLELEITESAIMSQAENSVQVLDALRVMGLGLVIDDFGTGYSSLAYLKRLPLNKLKIDQSFVRGLPDDAEDRAITRA
VIALAHSLQLTVIAEGVETEAQRDFLADEGCDEMQGYLRGKPMPLDEFRQRFLAG-----
>tr|F5RCZ7|F5RCZ7_METUF Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Methyloversatilis universalis (strain ATCC BAA-1314 / JCM 13912 / 
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------DE-----ARLLEEVI---MDLSFALRRLRDERERAS
AEQSARLLAAALRSTRDGVLLIDLAGVVVSANEAFCEQTGLDESALVGRALTEQAVFEGAAALFADIDRALRDGDAWQGEVSARRAGGEPWSGWLSCASV
RDDDGQPTHRVLVLTDISQARRAEAELQHLSQYDPLTDLPNRVLIRARLVHAIELAQRRGTRVAVLFLDLDNFKTINDGLGHAAGDEVLAAVAHRLRARL
RRQDTLGRQGSDEFVLVLEGVEAAEAAVVAQGVFDSLASPVRLSGQDIYLQASMGISLYPDNGHDADDLIRDADAAMYQAKLGGRNALRFYSDEYTHAAN
QRLSLETGLRRALESELFELRYQPLIDLASDRLIGAEVLVRLSPAAALNSSPAEFIPIMEANGLIVPLGDFVRSQALRQGRAWLDAGLPPLTLAINLSVT
EIRRGGLEQRIAQQLAESGYPVSLLELEITESGAMEQGERAQQFLEVIGSLGLRLAIDDFGTGYSSLAYLKRLPVHKLKIDRSFVCDLPDDASAVELVDT
IITLGHQLGLSVLAEGVENVGQRDLLRARGCDACQGYLYAPALSAEEFERRFLRS-----
>tr|B1Y791|B1Y791_LEPCP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) GN=L
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------EQ-----QALIAELG---SDMSHALAQFTREAQWQE
SLARTRLHAAALESTQDGVMVTDLRPRIVSVNRAFTEITGYSETEAVGMSPRLLQSGRHEPAFFTRLWNQLLTHGRWQGEVQNRRKNGELYTQWMSVSTV
RDEHDQPTHYVSVFTDITPQKEAEQRLQHLAHFDPLTQLPNRLMVLSRLEHAIASAARAERRVAVLFIDLDNFKTVNDSLGHSAGDDLLRAVADRLGTRT
RREDTLGRLGGDEFILMLEHLREQDAAQVAQELIGLLETPFRVAGQEVYVQASIGISLYPDDGLEVGELVRDADAAMYQAKRAGRGVYRFYTESLTTAAQ
SRLALDTRLRRALENKEFVLWYQPLYRLADRCLIGLEALVRLNQPGLPPIGPAEFIPLLEETGQITTLGAWVTQEACRQGRAWLDEGLDFGRIAINLSPQ
EIRRGQTDERVREALERSGLPAERLELELTESGLMEQGERAEAFLHRLRALGVRLAIDDFGTGYSSLAYLKRFPVSKLKIDRSFVRDLPADANDAQLVQT
MVSMGRNLGISVLAEGVETEAQFDYLRSLGCDAAQGYFFSPPRPADEARHWLRPL-----
>tr|R7XHP9|R7XHP9_9RALS PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Ralstonia sp. GA3-3 GN=C265_15402 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------EE-----MDLLREIG---GDISLALTRLNIVAKHAA
QAARIHLLAAALESSRDGIIITDLDTRIVSANRAFSSLTGYDEVEVVGHPLSLLRSGMHPVEFYREMHDTLAREGCWQGEIWNQSKSGKVLPHFLSISTV
TGDNGKAEHYVTVLTDLTRLKQAENRLDALTHFDPLTDLPNRLLIRARLEQSLAVAQQGGRRLAVLFIDIDHFQTINDGLGHAVGDELLVAVAQRLQAQM
RSHDILGRQSGDEFVVVLHDIEVSGADEFVRQLIEVFSAPFCLTVGELFVQVSIGVAVNPEHGSHAAELIRNAESAMHEAKRSGRATWRTYVPGFTSAAN
SRLALEARLRRALRQGLFELHYQPLVNLEDGKVIGAEALVRLPRDGGSDVGPSEFIPLLEDTGLILPLGAWVQREVCRQGRQWLDEGKAIEVLAVNLSAA
EIRSGHVQEQLRDILAETGFPPERLELEVTESGLMSRGSQAVEFLRSLKSLGIKLALDDFGTGYSSLAYLRRFPVDKLKIDRSFIRYIPDETGDMQLVAT
IVAMARGLGLRVLAEGVETEAQRLFLRKLGCDLWQGYLCSPPLPAAAFADRFLSS-----
>tr|A0A0A0DZP2|A0A0A0DZP2_9BURK Uncharacterized protein OS=Aquabacterium sp. NJ1 GN=JY96_18240 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------DE-----LSLFEDLS---GDLSFALHNLHREALRDE
AEERIRLHAAALESTQDGMMVLSRNRVLVSINPAFTALTGYDEDEVVGRSPEFLLPDRPEE-TLLDMRGEMIGSGYWQGEVWFRRKSGELFMTKLSVSAV
KSAKGRPTHFVGVFTDITQLKQTEERLARMAHFDPLTELPNRVMIHQRLAHAVNLAQRHHTLVGVIFIDLDNFKTVNDGLGHAAGDSLLKQVAQRLRQRV
RQEDTLGRLGGDEFILVLEHLRHQQAAHVATAILETLNQPFTLGGQQVYVRASIGISLFPADGQDAPELVRNADAAMYESKRRGRNSFSFYTESFTSDAT
SRLQLETRLRRAVEHGEFVLHYQPMISLATRKVTAVEALVRLRTPTEPSISPTQFIPVMEETGMIVALSEWVLQEACRQGKAWLDAGLDFGRIAVNLSPS
EIRRGGVVERLSRILNRTGLPPDRLEIEITESGLMESGMGAEQFLQMLHALGVFLSIDDFGTGYSSLAYLKRFPVHQLKIDRSFVQDLPGNDSDAQLVGT
MISMAHGLRMNVVAEGVEMPDQEAFLASRGCDVVQGYLYSRPVPAVQLEHLLENT-----
>tr|G2FFL6|G2FFL6_9GAMM Putative signaling protein OS=endosymbiont of Tevnia jerichonana (vent Tica) GN=TevJSym_am00640 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------RLRCRDGNQDLDQSRYIIATARDITERKA
TDEKLRQAAAVFESTAEGVMICDPQDRIVAVNRAFTEITGYSLEEMVGQKPSILSSGLHDNEFFQQIRSALHNSGRWQGEIWNRRMNGESFPEWLTISEV
RDPNGELTHYVSVFSDITTVKQAQQKLEHLAQHDPLTGLPNRLLIDEMLEHTIGGARREDKRSAVMFLDLDGFKTINDSLGHRVGDRVLQKVADRLRRAL
RGPDMVARLGGDEFLVVIERLDQADVAIIAEKLLAQFREAFPVEGRELFITASIGISLFPGDGATAADLIQHADSAMYRAKESGRNAYQFYETALTTNAQ
RHLDTASQLRHAIARKQFVVHYQPQFDLLSGALSGMEALVRWQQTDSRLVGPGEFITIAEQSGLIGEIGAQVMQQACHQAARWLKAGARFERIAINLSAI
QITRGNLQLQVKQCLQRTGLPPENLELEITESLFIDASEAILEQINALRALGITFSIDDFGTGYSSLAYLKRLPVERLKIDQSFIHDIPGDPGNAAIASA
VIGIGQSLGLRVIAEGIETEQQRLFLLQHNCPYGQGYLLGRPVPTEHFAKQFL-------
>tr|H8FVX9|H8FVX9_PHAMO Putative diguanylate cyclase (GGDEF)/phosphodiesterase (EAL) with PAS sensor Putative two-component sensor histidine kinase OS=
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------KVVTFAGRPRREGHTAVLLVGRDTTEVTA
AMRAVHRIRAIMDTVMDGIVTIDEEGTLLNANLSVERIFGYSLTEVVGSHVSLLLPELDSSRLTVAIHDYLSSFGA--AEAVGRRKDGTAFPVHMSVSEL
RVEN--RRLFTGTLRDLSENKQLAQRVDYLANHDPLTDLPNRTGLAERLGVAVVRARDSSRMVAVVTVDLDGFTTINDSLGHESGNLVLRETARRLAQNT
GPDGTAARLAGDEFAVVLPQLRDAEVSAGVERLREALNRPYIIQGTELTIGADIGVSVYPRDGDDAFDLLRNAEVALHSVKRLDDSRLGFFDAAMSFAVT
ERLTLERSIKAALKAEQFELFFQPQVRLIDFRLVGAEALIRWRHPELGIITPDKFIPVAEETGLIVPMGTWVLQSACRQLRHWDDLGLTGLRMGVNISGR
QFREQDLADLVAEAIAETGVNPAQLDLELTESMLMADGEATLKILRALARLGVTLSIDDFGTGYSSLAYLKRFPVNTVKIDRTFVSDLDQDKDGRAIANA
IISLAHSLGMKTIAEGVETEAQAAMLASHGCNEIQGYLIERPLPAAEFTAFVARY-----
>tr|M3AD07|M3AD07_9PROT Uncharacterized protein OS=Magnetospirillum sp. SO-1 GN=H261_07071 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------KVVTFAGRPRREAHNATLLVGRDTTEVTA
AMRAVHRIRAIMDTVLDGIVTIDEDGTILNANLSVERIFGHSLSELIGANVSTLMPEPDAGKHDGYIRNYLAGIGAVGREVMGKRKDGSLFPVHLSVSEL
RVEK--RRLFTGTIRDLTENKQLAQRVAYLANHDPLTDLPNRTLLTDRLGQAIAMARNAGLHVAIITVDLDGFTTINDSMGHDVGNSLLRETARRLAQAV
ASGGTAARLAGDEFAVVIAQVREDEVTAAVQHIHDILNKPYTIHGSEMVVPVDMGVSVYPRDGDDALELLRNAEMALHNVKRRSDQRMGYFDAAMSFAVT
ERMTLERSIKDALRAGQFELFYQPQVRLADYALVGAEALIRWRHPELGIITPDKFIPVAEETGLIVPMGSWVLRQACTQLRRWNDSGMVGLRLGVNISGR
QFREADLADIVADCISETGVNARDLDLELTESMLMADGEGTLKLLRSLAKLGVTLSIDDFGTGYSSLAYLKRFPVDTVKIDRAFVRDLDQDEDGRVLVNA
IISLAHSLSLKTIAEGVETESQAALLARHGCDEIQGYMIGRPMPAADFTTFAKSY-----
>tr|A4U2M2|A4U2M2_9PROT PAS:GGDEF OS=Magnetospirillum gryphiswaldense GN=MGR_1840 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------KVVTFAGRPRRDGHTAALLVGRDTTEVTA
AMRAVHRIRAIMDTVLDGIVTIDEDGLIVSANLSVERIFGYPLSELIGANVSILMPEPDAGRHDSYIKNYLQQGGGSGREVMARRKDGSLFPVHLSVSEL
RLDK--RRLFTGTIRDLTENKQLAQRVAYLANHDSLTDLPNRTLLCDRLGQALAAARGTGQHVAVMTIDLAGFTMINDSLGHDVGNGVLRETARRLAQWV
SHNGTAARLAGDEFAVILPGLRDAGVSAGTEQVLEMLNRPMTVGGSDLALPVDIGVSVFPRDGDEPLDLLRNAEMALHQVKKREDQRLGFFDTAMSYAVS
ERLTLERSLKEALKAGQFELFYQPQVRLSDYALIGAEALIRWRHPELGTIAPDKFIPVAEETGLIVPLGRWVLEQACRQLNLWQHQGLTQVRMGVNISGR
QFREVDLAETVAEVIRGSGIDARLLDLELTESMLMADGESTLRVLRRLADLGVTLSIDDFGTGYSSLAYLKRFPVHTVKIDRAFVRDLDHDEDGRTIAKA
IVSLAHSLNLKTIAEGVETEAQASLLLHHGCDEIQGYLIGRPMPVADFAVFAAGY-----
>tr|K9H5M2|K9H5M2_9PROT Diguanylate cyclase OS=Caenispirillum salinarum AK4 GN=C882_1720 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------KMLRADGAPDSAGGRSVMLVARDVTERQR
ATRAIERLRKIMETMVDALVIIDDRGIIETFNRAAERIFGYKAAEVVGRSVNILMSEEHATHHDEYIRRYKQGESHVGRVVEGRRKDGSVFPVELALSDL
KIGE--SHLFIGVLRDITERRAQEERLRYLATRDHLTGLPNRALFQTRLDEAVRDADAAGRHVAVLFLDLDHFKNINDTLGHPMGDRVLQAVGRRLEAQA
RPNDTVARLSGDEFTVILDGVDGEEASALATVLLDRLSDPFEIDGREIYTSGSIGIVMYPENAEDIANLMKNVDTAVNFAKKQGRNNFQFYTEKLSDDMV
RRLQIENGLRRALERGEMQVFYQAKIDLDSGDIVGCEALLRWFSKELGFVSPVEFIPVAEETGLIVPIGEWVLRESLRQLDTWMRAGLPPVRVGVNLSAR
QFREAELAGKITAILEETGVSAELLELELTESMLVENADEVIQSLWALKGLGITLSIDDFGTGYSSLSYLKRFPIDELKIDRSFVKDIPDSIDDMSITKA
IISMARSLEMKLVAEGIETDEQWEFLRDNGCHVGQGYLFAKPLPTSEFFDLMERR-----
>tr|C1DB08|C1DB08_LARHH Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Laribacter hongkongensis (stra
----------------------------------------------------------------------------------------------------
------------------------------------------------------------HSVATHEIHFDAVLVTPHG-VVGQGHYVTGSVQDVTSLRR
AERELMLSAQVFEHGSEAVFITDASHRILRVNPAFEAITGYAAGEVLGLTPDFRCVSSPGGTSISQRWELAEQTGRWQGEIVCRRRSGEHYYEWSALSVV
RHANGSVLYFIGQFSDISAVKAAEARALRLACFDPLTGLPNRSLLFDRLQEVLN---REPHNGAVLFCDLDRFKNINDSLGHTLGDAVLKEVARRLVARV
RPGDTVCRYGGDEFVLVLPGLSDVVLEQLAEQLLADVSSPILLDGLDLRVTPSLGVAVFPRDGNDCDALLRHADAALYHAKSRGRNTYRFFTREIDDRVS
EYLHIEHGLRSALERGEFELHYQPQVDMAFGRVVGVEALLRWKHPEQGMISPVRFVPIAEETGLIVPIGMWVIREACRQAMLWRRAGLRPMTMAVNLSGR
QFSRS-VIEAIDEALADSGLDPRWLQVEVTESVIMEDTQEAYTVLEALRARGLTVAVDDFGTGYSSLAYLKRFPIDKLKIDRSFIRDIDLDEDNPVIVDA
IIGMAHNLRIKVLAEGVETRAQWDYLRQQGCDEVQGYLVSRPQPAAALGQWMLER-----
>tr|A0A0C9NNE3|A0A0C9NNE3_9BACT Candidatus Brocadia sinica JPN1 DNA, contig: brosiA OS=Candidatus Brocadia sinica JPN1 GN=BROSI_A1979 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------EPAIRRCLEWASRYGFQSFAEPNADTETIRMLENLALIAM
DQQQLRLQGIAMESVANAVFITNCDGRIKWVNNAFIRLSGYTEGEVSGKTPRLFKSGKQDPSFYQQVWQTILAGKVWRGEIINRRKDGDLYTVNQTITPL
LDTHGKVCHFVAIHEDISDKKKIEERIHYMAHYDALTNLPNRNLFLDYLELELAHAHRNERMVAVMFLDLDRFKIINDTMGHVFGDKLLKAVAERMRACI
REGDTVSRLGGDEFTFIIPDIVQQDVVLIAQKILNAMSRSFQVEGRDIHVTPSIGIALYPSDADDADSLIKKADTAMYHAKEQGKNTFKFYREDMNVSNF
ERLTLENDLRKALEKGELFVYYQPLIDQDTGQIISMEALARWQHPDIGMISPAKFIPIAEETGLIVPIGEWVLMKACDQTRAWHDAGFHALRVMVNLSAR
QFKQQNLVNTITQVLQKTGLDPHYLELELTEGIVMQNDITILSALRELKALGILLSIDDFGTQYSSLSYLKRFPIDTLKIDRSFVHDITTNPDDAAIVTA
IIAIAESLKLKVVAEGVENKEQAAFLRKLRCNNIQGYVYSHPLPARAIEHLLQKG-----
>tr|A0A0A1VDL3|A0A0A1VDL3_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor OS=Acidovorax sp. MR-S7 GN=AVS7_00999 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------------GQQLTASDGTPEHAD--FVENTLRIFAERQT
-DARIS----LLDKARDAI-IVDLDHRITFWNEGAERMYGWTREEVLGRSIATLLYKDT--RDFERATAAVMQQGDWSGEILQYDRNGRAIEAEGRWTLV
RNDRGEPESVLAINADIGQRKESEREIQRLAFFDPLTGLPNRIRLMERIGQALRKAQHQRQGGALLFIDLDNFKTLNDTLGHDKGDQLLQLVAQRLTTCV
RGVDTVARLGGDEFVVMVEDLSAAEARGVGEKILSVLSTPYVLTGYQYRSTPSIGIALFNDAPTTVGELLQQADLAMYQAKTAGRSTLRFFNPGMQLAVA
ERASLEADLRNALSQQEFLLHYQPQIDA-QERIVGVEALLRWAHPQRGMVSPAQFIPLAEETGLILPLGRWVLHTACSMLAAWQHPALAPLTMAVNVSSR
QFRNDGFVDDVARVLAVTGAPPGQLKLELTESLLVEDMEATIATMEALRAHGVGFSLDDFGTGYSSLAYLKRMPLEQLKIDQSFVRDLLTDPNDAAIVRT
IIALADSLGLEAIAEGVETVQQRDWLAQAGCQCYQGYFFSRPLPSDRLEHLLSTR-----
>tr|J1E8T7|J1E8T7_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_06886 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------------GQQLCNADGEAADPN--FIISTLQIFAERQV
-DARIS----LLDKAQDAI-IVDLEHRIIFWNQSAERLYGWSKLQVLGQSIETLLYEDA--TQFRRATEATLEHGEWTGEIVQQHRDGSAIDVEGRWTLV
RGDNGQPHSILAINTDIRQRKATEREIQRLAFYDPLTGLPNRMLLMDRMHQALASARRHQRGGALLFIDLDNFKTLNDTLGHDQGDMLLQQVAQRLNTCV
RAVDTVARLGGDEFVVMLEELSSPDARSVGEKILATLALPYALAGYQYRSTPSIGVAPFTGGQASVGELLKQADLAMYQAKTAGRNTLRFFNPQMQAVVT
ERASLETDLRSALAQEEFLLHFQPQVRQ-SGLVVGVEALLRWAHPQRGMVSPAQFIPLAEETGLILPLGRWVLHTACKLLASWQDPALSHLTVAVNVSSR
QFRHASFVDDVARVLAITGAPSGLLKLELTESLLVEDMETTIATMTALRSYGVGFSLDDFGTGYSSLSYLKRMPLDQLKIDQSFVRDLLTDPNDAAIVDT
IIGLSRSLGLEVIAEGVETAEQRELLARAGCQLYQGYLFSRPLSVDVLEAFLRSP-----
>tr|H0BX89|H0BX89_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Acidovorax sp. NO-1 GN=KYG_09930 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------------GQQLCNGDGEAAETD--FITSTLQIFADRQL
-DARIS----LLDKAQDAI-LVDLQHHIIYWNKSAERLYGWTQLQALGQSIETLLYDDP--THFRHATQAVMDHGEWTGEIVQLHRDGSPIEVEGRWTLV
RGDDGQPQSILAINTDIRQRKANEREIQRLAFYDALTGLPNRMLLMDRMGHALANAQRRQQGGALLFIDLDNFKTLNDTLGHDQGDLLLQQVAQRLNTCV
RSVDTVARLGGDEFVVMLEELSPPHARGVGEKILSMLAVPYALAGYQYRSTPSIGIAPFTGEQTTVGELLKQADLAMYQAKTAGRNTLRFFDPDMQAVVT
ARAGLETDLRAALAQEEFLLHFQPQMHQ-SGRCVGVEALVRWAHPQRGMVAPAQFIPLAEETGLILPLGRWVLHTACKLLASWQDPALSHLTMAVNVSSR
QFRHASFVDDVARVLAITGAPSSLLKLELTESVLVEDMETTIATMAALRSHGVGFSLDDFGTGYSSLSYLKRMPLDQLKIDQSFVRDLLTDPNDAAIVDT
IIGLSRSLGLEVIAEGVETPEQRELLARAGCQLYQGYLVSRPLSVDLLDAFLHAP-----
>tr|B9M9T9|B9M9T9_ACIET Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Acidovorax ebreus (strain TPSY) GN=Dtpsy_0021 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------------GQQLTASDGTAERSR--FVSNTLQIFAQRQT
-DQRIS----LLDKARDAI-IVDLEHRITFWNEGAERMYGWSREEVLGRSIATLLYQNP--EDFLRATQHVMQHGVWSGEILQCDRAGRTLEAEGRWTLV
RNDRGEPESVLAINADIGTRKHQEREIQRLAFFDPLTHLPNRVQLLDRVDQALAKAQRLEQGGALLFIDLDNFKTLNDTLGHDQGDELLQIVAQRLNTCV
RSADTVARLGGDEFVVLVEQLSASDAGAVGEKILAVLSAPYALTGYQYRSTPSIGIALFNHAPTTVGELLKQADLAMYQAKTAGRNTLRFFNPSMQHAVA
ERASLEADLRNALAQKEFLLHYQPQINA-RGAIVGVEALLRWAHPRRGMVSPGRFIPLAEETGLVLPLGHWVLHTACSVLADWQRPALAPLTMAVNVSSR
QFRDAGFVDDVAGVLAATGAPAAQLKLELTESLLVEDLAATIATMAALRALGVGFSLDDFGTGYSSLAYLKRMPLGQLKIDQSFVRDLLTDPNDAAIVRT
IIGLAASLGLEVIAEGVETSAQRDWLAHAGCAVYQGYFFSRPLPLDLLEQLLHDH-----
>tr|F4GBX1|F4GBX1_ALIDK Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Alicycliphilus denitrificans (strain DSM 14773 / CIP 10
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------------GRQLASSDGTPAQVE--FVCSALQIFAQRQM
-DARIS----LLDRARDAI-IVDLEHRITFWNEGAERMYGWSREEALGRSMASLLHHDP--EDFLHATAQVLQHGDWSGEIVQRSRNGRSIEVEGRWTLV
RNDQGEPESILAIDSDIGPRKSHEREIQRLAFFDPLTGLPNRAQFMQRMGHALATARRQHQGGALLFIDLDNFKTLNDTLGHDQGDRLLQLVAQRLSTCV
RSVDTVARLGGDEFVVLLEQLTAAAANKVGEKILNVLCVPYALAGHQYRSTPSIGIALFDDTPTSMGDLLKQADLAMYQAKNAGRSTLRFFDPGMQRAVD
ERATLEADLRNALSQQEFTLHYQPQVDS-RGGILGVEALLRWTHPQRGMVSPAQFIPVAEETGLILPLGRWVLHKACTLLAAWQKPGLAHLTMAVNVSSR
QFRDPGFVGDVARVLAVTGAPSAQLKLELTESLLVEDMVSTIATMEALRAHGVGFSLDDFGTGYSSLAYLKRMPLEQLKIDRSFVRDLLADENNAAIVRT
IVALAASLGLSVIAEGVETDEQRNWLTRAGCTVYQGYFFNRPLSSDRLDGLLRSY-----
>tr|C5T7F6|C5T7F6_ACIDE Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Acidovorax delafieldii 2AN GN=AcdelDRAFT_2836 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------------GQQLCNADGEPKDPD--FVTSTLQIFADRQL
-DMRIS----LLDKAQDAI-IVDLDHRIIYWNKSAERLYGWSQLQALGQSIETLLYDDP--AQFRRATQTTVEQGEWTGEIVQRHRDGSPIDVEGRWTLV
KDDAGRAHSVLAINTDIRERKATEREIQRLAFYDPLTGLPNRMLLMDRIGQALATAQRRHQGGALLFIDLDNFKTLNDTLGHDQGDLLLQQVAHRLNNCV
RSVDTVARLGGDEFVVMLEELSPPDARAVGEKVLAMLAVPYALKGYQYRSTPSIGIAPFDGDQATVGELLKQADLAMYQAKTAGRNTLRFFDPAMQDVVT
ARAALEEDFRTALANDEFLLHYQPQVNL-AGQCVGVEALVRWAHPQRGLVSPAEFIPLAEETGLILSLGRWVLHTACTQLALWQDPMLSELTMAVNVSSR
QFRHASFVDDVARVLAITGAPSGLLKLELTESLLVEDMETTIATMAALGAYGVGFSLDDFGTGYSSLSYLKRMPLDQLKIDQSFVRDLLTDPNDAAIVDT
IIGLSRSLGLEVIAEGVETPEQRDLLARAGCHLYQGYLFSRPLSAGSLEAFLRPC-----
>tr|A1TI51|A1TI51_ACIAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax citrulli (strain AAC00-1) GN=Aave_0022 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------------GLQLRSAEGQPQQPG--MVISTLRIFAARQA
-DAHIS----LLDKARDAI-IVDLDHRITFWNEGAERLYGWTREEATGQSIAELLYQDT--QEFLRATRATQEQGEWAGEIVQFHRDGRRLDVEGRWTLI
QGEQGQPDAILAIDTDIGQRKATEREIQRLAFYDSLTGLPNRMLLMDRMRHALATAQRRRQGGALLFIDLDNFKTLNDTLGHDQGDVLLQQVAARLNTCV
RSVDTVARLGGDEFVVMIEGLSTPGARTVGEKILAVLATPYVLQGYHYRSTPSIGVAPFGDRTSTVGELLKQADLAMYQAKTAGRNTLRFFDPGMQAVVT
ARAELENDLRTALAREQFMLHYQPQIDR-RGSVTGVEALVRWPHPQRGMVSPGEFIPLAEETGLVLPLGRWVLHTACAQLARWQHPGRGHLSMAVNVSSR
QFHHEAFVEDVVRAITATGAPASRLKLELTESLFVEDMETTIATMAALRSHGVGFSLDDFGTGYSSLSYLKRMPLDQLKIDQSFVRDLLADPNDAAIVDT
IIALSRSLGLDVIAEGVETAEQRTRLEQAGCRAYQGYFFSRPLPETALEDFLVQK-----
>tr|J0KE57|J0KE57_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_05934 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------------WRRLDSASGRSELDA--MMASTLHIFAERQE
-DAQIS----LLDKAQDAI-IVCLEDRVLFWNRSAQRLYGWTPQEAIGRSISHLLYDDA--HAYQQAIRNVLALGEWNGEFTQHRKDGSTLTVEAHWTLV
RDEHGMPRSILAINTDITQRKVTELQIQKLAFFDPLTGLPNRIRLVDRLQHALVASARNGRGGALLFIDLDNFKTLNDTLGHDKGDLLLQQVATRLKGCV
RETDTVARLGGDEFVVMLEQLSGASGRTVAENVLHALNQPFDLMGYEHRGTCSIGIAPFAQ-TEEVGELLKRADLAMYQAKTAGRNTLRFFDPDMQQAVT
ARAALESDLRQALAQDEFLLHWQPQVDS-QGEMLGVEALLRWKHPQRGMVSPAVFIPLAEETGSILPLGRWVLEAACAQIAAWSAPETAGLTVAVNVSVL
QFRHPDFVDQVLAVLDKAGANPRRLKLELTESLLVSDMEETVTKMAALKRRGVCFSLDDFGTGYSSLYYLKRLPLDQLKIDQSFVRDLLSDPNDAAIVRT
IVALAQSLGLHVIAEGVENESQQQFLAEHGCHAYQGYLFSRPLAADQLKAFLEAR-----
>tr|B1X1F3|B1X1F3_CYAA5 Uncharacterized protein OS=Cyanothece sp. (strain ATCC 51142) GN=cce_2032 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------FRCRDGQELWTIVSTNPLF-DHQGYLGSLGMITDISQRKK
MEQALQRLEGILNSIQDVVWSFDANFKLIYINPVAQMTLGFSLEKLYDNPLQLIHPEDQEL--VQYHRQIVKEIGY--------RNNDKIRWLSSRMRCV
YNDKNNLIRIDGIDSDITEQKRAEEQLQYNATHDPLTNLPNRILFMDRLEHAIERQKRHPFIFAVLFLDLDEFKVINDSLGHAIGDQLLQEIALRLQNGL
RSDDTLARLGGDEFTILLEDIEDKDAIKIAKRIHLDLTQPFILEDQNIFINTSIGIALNSS-YQEAAEILRDADTAMYRAKADGKACYAIFDHKMHERAV
SRLQLETDLRIGINKQEFCLYYQPIISLKTGHLTGFEALIRWYHPQKNLISPGQFIPIAEETGLIIPIGEWTLKEACQQLKKWQNQFPHYSKVAVNLSSK
QLKYTNLIDTIDQILRDTQLDSKNLKLEITETLLMENLQAATEILLKIQERDIEICLDDFGTGYSSLSYLHRFPVNTLKIDRSFVMRMEPDNENAEIVRA
IVSLAHILGLDIIAEGVETELQLAQLRRLGCEQGQGYLFAKPLPASEVENWLRNP-----
>tr|B7JWK6|B7JWK6_CYAP8 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cyanothece sp. (strain PCC 8801) GN=PCC8801_4425 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------LRRQDGSELWAIVSTNALF-NPEGYMGTLGLITDITKRKR
TEQALKRLEGILNSLQDVIWSADPKTQSLYLNPAIQLVYGRPMEDFFRDPLCMVHPEDQEL--VSHHLKLLEDKGS--------RPDGETRWLHSRSRLV
YDEQGKSLRIDGINSDITERKQAEEQLQYNATHDTLTQLPNRLLFMDRLEHALERRRRYSPLFAVLFLDLDEFKVINDSLGHALGDELLREIARRLQKSL
RADDTLARLGGDEFTILLEEIHDKDAIKIAERIHKDLTRPFNLEGQEIFTNTSIGIALSNG-YEAASEILRDADTAMYRAKAGGKACYAIFDQQMHASAV
SRLQLETDLRRAIERQEFLVYYQPIISLQHDTLTGFEALIRWQHPQQGLVPPARFIPIAEETGLIVPIGEWILEQAAQQLKIWQTQYRNYEKMSVNLSSK
QLRDASLLGTIDRILSKTEIDNNALKVEITESILMENVQVAADVLIALRERNIEICLDDFGTGYSSLSYLHRFPVNTLKIDRSFVMRMRPNDENSEIVRA
IVSLAHILGMEIIAEGIETELQLAQLKWIGCEQGQGYFFAKPLATSEVEALLKNP-----
>tr|K9T5C9|K9T5C9_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Pleurocapsa sp. PCC 7327 GN=Ple7327_1970 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------LRRQDGTDLWTILSSNPLF-DSEGYAGALGMITDITDRKR
IEQALRRLEGILSSIQDVVWSASATTKTLYMNPTAEKVFGRSASEFYNHPFKIVHPEDKKQ--VKHYLKQLHETGS--------RPDGEVRWLYNRSQVI
YDGSGKAIRIDATDTDITERKQAEAQLQRNAFYDPLTDLPNRALFTDRLEHALQRLKRHPSLFAVLFLDLDGFKLINDSLGHLMGDRLLQGFARRLSEYL
RPSDTLARLGGDEFTILVEDIKTKEAVLIAERILQTLTLPFDLDGQQVFTNTSIGIALSNS-YQSSEEILRDADTAMYRAKGQGKGCYAVFDTKMYLLAV
SRLQLETDLRRAINQQEFLVFYQPIVSLKSGKITEFEALIRWQHPKRGLILPAEFIPIAEETGLIIPIGQWMLKEACQQMRTWQEQFPQQLKININLSGK
QLRGTNFIEQIDRVLAETGLDGSTLKLEITESLLIENVEVATDLLLELRKRNIELCLDDFGTGYSSLSYLHRFPVSTIKIDRSFIKQIKPEDDSSEIVRA
IVALADILGMNAIAEGIETKEQLEQLKKLACEKGQGYLFSKPLSKEDAEAFLQKG-----
>tr|A0YYE1|A0YYE1_LYNSP Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensors OS=Lyngbya sp. (strain PCC 8106) GN=L
----------------------------------------------------------------------------------------------------
------------------------------------------------------------NYRKDGRLFWNDLQIAPVF-NDRGLTHFIGVQNDITERYE
AQEEVNFLQTMIDHLPVAVFVKEAYQRFRLWNKACEQLFGLSAVEVLGKT-D-VFPPEQAE-FFHQQDQAVLSAGK--------TQTLGQRILHTVKVPL
LNHYPDTEYLLCIGEDITKRKQAEDQLRHHAFYDTLTNLPNRALFLNRLAHSIKQVQQTSELFAVLFLDLDNFKRVNDSLGHQIGDQLLIAIARRLEGCL
RSRDTLARLGGDEFTILLEQINNTDAIKVARHLHQQLMLPFNLSGNEVFTNVSIGIALSCSHEQHPEELLQNADSAMYRAKEMGKGAYAVFDTRMHRQAV
ERLQLESQLRRALELNEFQVYYQPIVSITTGEVIGFEALIRWLNPYKGFISPALFIPVAEEIGLISKIGQWVLYQACEQLQVWRKQFPLFKTVSVNLSSQ
QLREPDLLEQIDQVLATTGLPSHCLKLEITESLLIENYDQALKILRQIQDRNIQLSLDDFGTGYSSLSYLHRFPINTLKIDRSFVKRLKQNHENTAIIKA
ILRLANALAMNTIAEGIETVFQLEKLKGLGCEYGQGHLFSKALDAQDITHLLSLI-----
>tr|K9VT15|K9VT15_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Crinalium epipsammum PCC 9333 GN=Cri9333_0049 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------QRQFTKDDVYF-------------LQSVANVVATAIERKQ
AEEALERYALAVNGSKEGLWDWNLKADQVYFSPRWKAILGYQDHEIGDRLLDRIHPEDIEP-VRTALNSHLEGLIS--------HQDGRYRWMLCRGLAI
WDANGQAYRMSGSQLDITDRKIAEEQLSYDAVHDALTSLPNRALLMDRLGQAIARQRRHKYQFAVLFLDLDRFKVVNDSLGHIVGDQLLIEIARRLQAPQ
RPGDTVARLGGDEFVILFDEITDQEVTNLVEHLQKELGKPINLDTQTIFISASMGIVLSQDTYDWAGDLLRNADIAMYQAKNLGKARYVVFNSIMHTSAV
ARLQLENDLRQAVEQSKLLLHYQPIISLSTGKITGFEALVRLWHPQRGMVSPSDFIPVAEETNLIMPLGAWVLQEACRQLQIWNLTYPG--TISVNISGK
QFSQPDLVAQIKQILQNTNLSADQLKLEITESVIMENAESATAMLEQLKNLGVQLSIDDFGTGYSSLSYLHRFPIDTLKVDRSFVSRMSIDGNNWKIVQS
IITLAHTMRMDVTAEGVETVNQLEQLRALECEQGQGYFFSKPLDIEAASQFLDKG-----
>tr|U7QIE3|U7QIE3_9CYAN Diguanylate cyclase domain protein OS=Lyngbya aestuarii BL J GN=M595_3807 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------ITTPSGCQKWLQTLAKPER-RLNGV-IWEGLILDISDRKR
AEMALERYRLLAENMSDLVCIHNAEGQYLYVSPSCQLLLGYDDKELIGQD-TFFHPEDCDQ-IFQTSHQ-AALIGQ--------KKSGDYIWLETLTTPI
LDDTGQVVRLQTTSRDVTDRVQVEQQLRYDALHDSLTELPNRHLLIDRIELALQRLKRYQFQFAILFLDLDRFKVINDSLGHVVGDELLISVAQTLQGLI
RQVDLAARFGGDEFVILLEEIDNNEAVQIAKRIITELQSPFILNQQEVFITPSIGIVYGSSDYHQAIDLLRDADAAMYRAKAKGGERYEIFDPSMYLQAL
KRLHLENDLRQALDQKDFILYYQPIVSVETGKITGMEALIRWQHPQKGLIPPSDFIPVAEETGLIVPMGMWVLKTACSQMKTWYQHFPNTQKISVNLSGR
QLREPTLIEQINQALTEIYFPPQLLTLELTESMLLDDVENIITLLSNIRSHSIQLSIDDFGTGYSSLSYLQRLPLNTIKIDQSFVNCIGEQGENSAIIDI
IMTLATKLNLEVIAEGIETRTQFEYLKNIGCPFAQGYLIAKPLTVDALTTLFQED-----
>tr|T1AVW2|T1AVW2_9ZZZZ Diguanylate cyclase/phosphodiesterase OS=mine drainage metagenome GN=B2A_03667 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------RLRGRADETWVEL-GFVRA-RSDT---WYMVARDISRQMR
AEAEARLLQRAVEAVENGVVISDADTPLVYVNPAFTHITGYRADAVIGRNARFLYRDDADQPGLRELDQAMADGSAASVVVRNYRQDGSLFWNRLRIAPV
RDAHGL-SHWVGIQQDISEERRVEDHLQQLALSDELTGLPNRRALLVDVDALLP-----REPLALVHLGLDQFKLINDALGHASGDELLRKLGTRLRAAL
PGTVLLARFGGDEFVALVPRITALQ--RVLELISDNVRRPIELQGTLQQLNCSIGVALAPEHGDGADALMRSADAAMHEAKRLGRNRSVTYSTHLHEAAR
QRLAVISRLRGSDLGRELALHYQTIHDGASGAIVGVELLLRWPHGPEGLRSPGALVPLLEESGLILPVGRWVLHEACRRQQQLQGL--AAAKVALNVSTQ
QLMLGDFVGDVREALAASGADPALLELEITESALMADPGKAEAILQQLKRLGLGIAIDDFGTGYSSLGYLHRLSVDKLKIDRSFVSDVLGDRDDALICAS
IIQLAHSLGLSVVAEGVETEAQRHWLAARGCEQMQGYHFARPIPFADAAD----------
>tr|A0Q539|A0Q539_FRATN Signal transduction protein with a PAS, a PAC, an EAL and a GGDEF domain OS=Francisella tularensis subsp. novicida (strain U112
------------------------------------------------------------------------FYTLLRDRDIFNALEHSSLDGLWYWDLE
NPQNMWLNKWQI-LGYDPDQKKHLASEWQ-NVVYPDDLNKVKQEAKHLADPSYKYSAIVRYKHRNGSIVWIKCSGIAIRDENGKPLRVLGTRSDISDLKQ
IELKLKETQLMFDASEDIIFVKDKNYCLVRANRAFFNLFPKNTHSSIGSTLIE-NFNSSDAEYFLKYDALAFETGSSKTIEYIKLPNGEDRILDTYKIRF
YD-KNNTPYLLGIARDVTELKDTNKKLEEIAYKDDLTGLLNRKGFIKKASNHIAEIQ-NLNLVTLFCIDLDNFKFINDSFGYNIGDELIIKISKRLKNFF
NKDAIIGRSGGDDFLILTDNLQSIEIAQIAENLIKEIAKPYIMKGNTFSQSSSIGIAIYPNVADNFEKLIQFADTAMHHAKAKGKNTYSFYSLDYDQKTQ
RRNSIDRELRNA-EMAEFTIVYQPQFDI-NNEIYGVEALVRWQSPKLGNISPEEFMPIAEKNQTIKNIGKWIFIRTIQDWNKLLSLNLANNKLSINVSSV
QILQENFCSEVINI--ISNIDKHSITLEITETHLLANIDLTRTVISNMNKLGISFALDDFGTGYSSLKYLANLPIDYLKIDKEFVQNLNIQ-NNKEIIIA
ITQLAKNLNKYCIAEGIETLEQFNFLKSIGCNFYQGYYFSKPISFLALKKLLQS------
>tr|H1G3Y9|H1G3Y9_9GAMM Uncharacterized protein OS=Ectothiorhodospira sp. PHS-1 GN=ECTPHS_07536 PE=4 SV=1
------------------------------------------------------------------------YELIRGDAQSFDFLQQATLDGIWFWDLE
HPEHEWMSDWTM-MGYDPAGKQPLASEWQ-SLVHPDDMKSVQQAERHFADPACPFDQVVRYTHRNGSTLWIRCRGMVVRDDQGRPVRMLGAHTDITLIKQ
IQTALETRTRAMDNAQEGIIITDAQARILSVNRAFTQITGYTAQEAVGNNPRMLKSGRHDADFYRAMWWDIIQTGTWQGEIRNRRKNGEEYPQWTAISRV
PGEDGE-HDYVAVFSDLTDKKQADERIAFLAHYDPLTGLPNRHLLMDRLHQALAYHQRQGLHLALITLDIDDFVAINERLGHQAGDQILGRIARRLQDAL
READTVSRLGGDEFVIIIHSLTDEQIHAIIRKLHSGFVQPMDSEHGDISLTASMGIALSLPDV-DADTLLRHSHHAMFLAKQKGRGAFHIFDTSHARMMD
ELREQRQRIHQGVKQGEFVLFYQPKVDLRSGCVRGVEALIRWRHPERGILSPAEFLPRIIGTDLEFQVGDWVLTEALRQMSSWKMNGRNI-AVSVNVAAP
HLLQHGFASKLADMLNHPQLAPGDLEIEILESAAVEDWQMAALAMQDCRTLGVRFALDDFGTGYSSLVHLRRLALDTLKIDKGFVGDMLEDPEDFSIVES
VVSLAISFQLEAVAEGVETERHARVLMKMGCPTVQGFGIARPMEADRIIPWIED------
>tr|H3ZFT7|H3ZFT7_9ALTE PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Alishewanella jeotgali KCTC 22429 GN=AJE_10909 PE=4 SV=1
------------------------------------------------------------------------FSEN-------------VPGFFFQLERQ
PRLVSDSAAQS--LGMALTEIRQNAALAL-ARVHPDDLE-----ILHSAQHLSPWSLQFRYQHAGDY-RWFEGHATPR-------------------EQA
LAEYA----EIVDNILDAIITIDQGGLIETFNNAAIRIFGYQPVEVIGKNVSMLMPEPYRSAQYIDAYQR-TGEAKQSRETKGRRKDGRLFNMELRISRI
ER--VDSYKFIGMVRDLSERKRTEVLIEKLAFYDPLTQLPNRRLLKQRLADILKQRQPGEELGALLYIDLDNFKHLNDSLGHSTGDQLLRQVASRLLQSV
RQHDTVARLGGDEFIILLQNLSPKQAELVAEKVRSTLNTPFTLEQLSYVSSPSIGITLFSDDNHSIDELLQQADLAMYQAKAAGKNSIKQFDVSMQVKAS
ERTRLESELREAINRQQLQLYYQGLHDA-AGQLLGAEVLLRWFHPELGNVSPARFIPIAEESGLIFEIGSWVIEQACQQLSRWQAQQLVPGKLSINISAR
QFHQDNFLPKVMHILDRYSVARDRLQFELTESILVSRVDEVISKMQALKQYGIAFALDDFGTGYSSLSYLKRLPLEQLKIDRSFVADILHDPNDAAIAST
VIALSAALGLGVIAEGVETAAQRDALAALGCYHYQGFYFSRPVPGGDFVALHRH------
>tr|I9NZK5|I9NZK5_9ALTE PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Alishewanella agri BL06 GN=AGRI_12641 PE=4 SV=1
------------------------------------------------------------------------FSEN-------------VPGFFFQLYRK
PQLVSESAGKA--LGIALPQLGQDSAAAL-ARVHPDDVD-----IQHSAQYLSPWSLQFRYQHAGDY-RWFEGNATPR-------------------ELA
LAEYA----EIVDNIIDAIITINEAGLIETFNNAAVRIFGYQPQEVIGKNVSMLMPEPYRSAHYIDAYQR-TGEAKQSRETKGQRKDGRLFNMELRISRI
QR--VDSYKFIGMVRDLSERKRAEVLIEKLAFYDPLTQLPNRRLLKQRLAETLKQRQPGQELGALLYIDLDNFKHLNDSLGHGTGDQLLRQVASRLQQSV
RQHDLVARLGGDEFIILLHNLSPRQAELVAEKVRTALNTPFKLEQLSYVSSPSIGITLFSDDNNSIDELLQQADLAMYQAKAAGKNMIKFFDVAMQVKAS
ERTRLESELREAIKRQQLQLYFQGLHDG-QGKLLGAEVLLRWFHPELGTVSPAVFIPIAEESGLIFEIGSWVIEQACRQLAIWTESKQALQKLSVNISAR
QFHQENFLPQVIQTLERYGVARNRLQFELTESILVSRVDEVVAKMNLLKNYGVAFALDDFGTGYSSLSYLKRLPLEQLKIDRSFVDDILNDPNDAAIAST
VIALSEALGLGVIAEGVETAAQRDALAALGCYHYQGFYFSRPLPGQDFVAMQQQ------
>tr|A0A0C1UBR1|A0A0C1UBR1_9CLOT Diguanylate cyclase domain protein OS=Clostridium argentinense CDC 2741 GN=U732_737 PE=4 SV=1
------------------------------------------------------------------------YHSLSIEEKRCNLALSAFDGAIWEWNLN
T-EFYLSSKGDQLLGIEGSSQSNSINSLS-KFVHPEDLYPLFICFLKKISNDKEFSHEYRIIQKDENIKWVRCSGK-IYRSKK----ASGFIIEITEQKK
QQLALIENQLTIAGSLDSICEVDLKKKIMNFSSSINNILGDDKANEIKY-YRHWMEDE--DKYCKGIKEFLNSNEVYADQYRILNANNEIVWLETRSKAT
FDELGNKDYL--------KEKFEKSKYGRLQYNDDLTGLPNRFFLREALIKKEIDASLKMEKIALISVDIDGFKHINDTFGHNYGDELLRQVAERLKLIV
GEDDILCRFSGDEFSFLIEHIKGIDLENRAKQIIKLFNSPVKIFDNEVFISVSIGMALYPDHGEILSDLVYKADMAMYKAKSLGKNQYYLFEFNDLEKVN
RIFSIEKDLSEALNKNEMYLVFQPKISTDNEEMVGLEALIRWKHLEKGFISPVEFIPIAEYTKTIIPIGRFVFDEACKKCRELLNMGYDNFKISVNLSKV
QLEDKNLTNNFINILKKYNLDPKYIELEITESVIIDVLEKNLDVLDKLHKYGMSISLDDFGTGLSPLKYLKLLNLDCLKIDKSFIDDIGINKKSEHIIDG
LIKLAHSLKLSVIAEGVETEEQIKYLKANNCDIIQGYYYAKPMIFEETVKFLKN------
>tr|A0A0A7FYF6|A0A0A7FYF6_9CLOT Diguanylate cyclase domain protein OS=Clostridium baratii str. Sullivan GN=U729_127 PE=4 SV=1
------------------------------------------------------------------------NKEYNINRLRYKRAIKGLNGVVWELDED
N-SLYISSRARELLKTDEII--DTYEKFE-KYIVEKYRCEVRETFYNFSGKTGNFVIDFDIRDKNGRIIPIEVKGS-IERIDG----GT--AFDLIYKKK
QESLLKESELALNGTKDIMFQWNIEDNRIKLEGNLHSILYVMESKSNVT-LEDFLCEE--DRILDVYKICIEGNESYECEFRMKS-VRGISWIRLRGMVH
--NEEGKQII--------DRKEKEEKIYYMNYYDKITNQPNRRYFEEY-TKTKIEKYLLEKNLAIACIDLDNLKDVNDNYGHDLGDELLKQFCVVIKKEL
YKKGFLARFEGDEFVVSIEGYNSKELEDYLKKIVSMFDKPIRIDTVDVYCTISIGVSFLREDGTDLKTLLKKADIAMYNAKSLGKNQIRFFDKEIENTIK
RNLKITDELKKALERNELYGLLQPKVNTFSKRIEGFEYLIRWNNRELNYVSPYEFITLAEKSGDIIEIGKFIIEDAIKICRKINDISVHQMKVAINISPI
QLRDNEIVNVIRENLKKYGVSAKNIEIEITESTMINSITKNSKVINDIKKLGVTIALDDFGTGYSSFSYLRDLPIDVIKIDKSFIDYIGKDKKSEYIIEK
LIELSHYFNLDIVAEGVEYDSQYKYLKEINCDTIQGYYFYEPLSIEETLKIIKE------
>tr|E6RPP3|E6RPP3_PSEU9 Uncharacterized protein OS=Pseudoalteromonas sp. (strain SM9913) GN=PSM_A1041 PE=4 SV=1
------------------------------------------------------------------------HSQLQLSEKRLKSTVEGSGDTLWDWNIK
TGKVIRIND--VMNS-----NNVEFPPNK-SLIHPRDLTHVDYLKKHFAEESTFFEATYRIKDSFGKWHWVLDRGKIIKDANLSPLRMTGTVRDISQLKS
TEDRL----KCVESLTDALAIYDKDFRLVDINPSFLTLFGGVREQYKKE-------HLAGYDYIESIKNTVRKHEHIQEEVKLRNSDHALLPFEISIDEI
KNAQNQITNYVVVYSDLTERKKTESELNNLSNRDRTTSLPNRNLFFSDLQKLAKQ----HSHHALLVFDLDNFKKINDSLGHQLGDSLLAKLAMRLNKLT
RENDVFYRLGGDEFALVMSNTNDLTITRMAKQFLAAIATPFKMAGHELAITSSVGIVLFPEDGNTPEILLKNADTAMYHAKKKG-NSYLFFNDTMNRQAV
KRLQIENLMRFGLKEDHFEVYYQPKMNIRTGKLAGMEALVRFITPKKGVISPGVFIPIAEETGQIIEIGEVVLNKACRDVKQWLDAGLFNARVAVNLSAK
QFSLPDLTSRIDVILQKNELPSYFLELEITEGTVMDDPQEAIAIMRSLSARGIHLAMDDFGTGYSSLAYLKQFPLNTLKVDKAFIDDMKTE-RGRNMVDS
IVTIAHNLDLHVVAEGVEQASQISILEELNCETLQGYYYSKPLSKDEFTAFLKQ------
>tr|G7G6Z0|G7G6Z0_9GAMM Signaling protein ykoW OS=Pseudoalteromonas sp. BSi20495 GN=ykoW PE=4 SV=1
------------------------------------------------------------------------RRQLRLSERRLKSTVEGSGDTLWDWNIK
TGEVIRIND--MMNS-----TTIGFPPNK-SLIHPLDITNVEHLKKHFAEKTVFFEATYRIKDTFGRWHWVLDRGKIIKDTNLSPLRMTGTVRDISQLKS
TEERL----KCVESLTDALAIYDKNFKLVDINPSFLTLFGGVREQYKKD-------TLPGYEFIDTIIEIVRENEHIQREVKLRNSERVLLPFEISIDEI
KNDQNQITNYVIVYSDLTERKKAESQLHNLSNRDRTTSLPNRNLFFTDLHKLVKQ----NSHHALLVFDLDNFKKINDSLGHQLGDSLLAKLAMRLNKLT
RENDVFYRLGGDEFALVMSDTNDHVITRTAKQFLAAIATPFKMAGHELAITSSVGIVLFPEDGNTPELLLKNADTAMYHAKKKG-NSYLFFNDTMNRQAV
KRLQIENLMRFGLKEDHFEVYYQPKMNIRTGKLTGMEALVRFITPKKGIISPGVFIPIAEETGQIIEIGEVVLNKACRDVKQWLDSGLFSGRVAVNLSAK
QFSLPDLTSRIDVILQKNELPSYFLELEITEGTVMDDPKEAIAIMRSLSARGIHLAMDDFGTGYSSLAYLKQFPLNTLKVDKAFIDDMKNE-RGRNMVDS
IVTIAHNLDLHVVAEGVEQAEQIEILKKLNCETVQGYFYSKPLSKDEFTDFLKQ------
>tr|Z5XQL2|Z5XQL2_9GAMM Diguanylate phosphodiesterase OS=Pseudoalteromonas lipolytica SCSIO 04301 GN=AT00_08495 PE=4 SV=1
------------------------------------------------------------------------RHQLRISEHRLKSTVEGSGDTLWDWNIK
TGEVIRIND--TTDT-----NNNGFPPNR-DLIHPHDLPHVENAKRHFAEHTAFFEASYRIKDSFDRWHWVLDRGKIIKDTNLNPLRMTGTVRDISQLKS
TEARL----KCVESLTDAIAIYDKNFKLVDLNPSFLTLFGGSREQYKKD-------ALLGYDYVDEIKATVKATEHWQQEVKLKNAQRQLLPIEISIDEI
KNEHNQICNYVVVYSDQTERKKAESQLHNLSNRDRTTGLPNRNLFFTNLKKLAKQ----DNHHALLVFDLDNFKKINDSLGHQLGDSLLAKLAMRLNKLT
REKDVFYRLGGDEFALVMSGTNDHTITRMAKLFLAAIATPFNMAGHELVITSSVGIVLFPEDGNTPELLLKNADTAMYHAKKKG-NSYLFFNDTMNREAV
KRLQIENLMRYGLKEDHFEVYYQPKMNIHTGKLDGMEALVRFITPKKGIISPGVFIPIAEETGQIIEIGEVVLNKACRDVKNWIDQGLFNGRVAVNLSAK
QFSLPDLTTRIDLILQKNELPSYFLELEITEGTVMDDPQEAIAVMRSLSARGIHLAMDDFGTGYSSLAYLKQFPLNTLKVDKAFIDDMQTE-RGRNMVDS
IVTIAHNLELHVVAEGVEQAKQVEMLKELKCQTVQGYYYSKPLSHPEFTAFLKS------
>tr|U1JK21|U1JK21_9GAMM Uncharacterized protein OS=Pseudoalteromonas citrea NCIMB 1889 GN=PCIT_16590 PE=4 SV=1
------------------------------------------------------------------------HQTLSLSEHRLKSTVEGSGDTLWDWNIA
TGEIIRIND--MMHK-----SAGEFIPNA-NRIHPQDIALVDRLKQHIGEKTAFFEASYRIKDSLDQYHWVLDRGKIIKDNNLNPLRMTGTVRDISHLKS
TEERL----KCVESLTDAIAIYDRNFNLVDLNPSYLKLFGGVRVQYGRP-------TLSGYDYMSEIKACLKDTEHWQEELKLRNHKDILLPIEITIDEI
KNNQGQITNYVVVFSDLTERKKAESQLHNLSNRDRTTGLPNRNLFFTNLKKLAQQ----NTHHALLVFDLDNFKKINDSLGHQLGDSLLAKLAMRLNKLA
RQQDTFYRLGGDEFALVMSGTNDHTITRTAKQFLAAIATPFKMANHELVITSSVGIVLFPEDGATPEILLKNADTAMYHAKQKG-NHYLFFNDSMNEQAV
KRLQIENLMRYGLKEDHFVVYYQPKMDIKTGKLVGMEALVRFITPKKGIISPGVFIPIAEETGQIIEIGEVVLDKACKDVKNWIDQDLFNGRVAVNLSAK
QFSLPDLTTRIDVILQKNQLPSYFLELEITEGTVMDDPKEAISIMRSLSARGIHLAIDDFGTGYSSLAYLKQFPLNTLKVDKAFVDDMNTE-RGRNMVDS
IVTIAHNLDLHVVAEGVEQAEQLVMLEELNCETVQGYYYSKPLSPEEFSEFLKA------
>tr|A0A0C1LKD4|A0A0C1LKD4_9GAMM Diguanylate phosphodiesterase OS=Pseudoalteromonas elyakovii GN=QT15_09720 PE=4 SV=1
------------------------------------------------------------------------TLQLKHSEQRFKSTIEGSGDTLWDWNIQ
SGEIVRIND--GMNS-----AKGSVIPNQ-HRIHPQDLLIVEKLKQHFAEKTPFFEASYRIKDELGQYHWVLDRGKIIKDANLNPLRMTGTVRDISHFKS
TEERL----KCVESLTDAIAIYDRHYNLVDLNPSYLKLFGGQREHYNKH-------SLPGYDFVAQVKAQLKQTEHWQEELKLRNAADVLLPIEITIDEI
KNNHGQISNYVVVYSDLTERKKAESQLHNLSNRDRTTGLPNRNLFFTNLQKLSLQ----GTHHALLVFDLDNFKKINDSLGHQLGDTLLAKLAMRLNKLA
RQQDTFYRLGGDEFALVISGTNDHTITRTAKQFLAAIATPFKIANHELVITSSVGIVLCPEDGKSPESLLKNADTAMYHAKQKG-NHYLFFNDSMNEQAV
KRLQIENLMRYGLKEDHFVVYYQPKMNIKTGELVGMEALVRFITPKKGVISPGVFIPIAEETGQIIEIGEVVLDKACRDVKRWIDKGLFNGRVAVNLSAK
QFSLPDLTTRIDIILQKNQLPSYFLELEITEGTVMDDPKEAISIMRSLSARGIHLAMDDFGTGYSSLAYLKQFPLNTLKVDKAFIDDMGNE-RGRNMVDS
IVTIAHNLDLHVVAEGVENEEQLNILEQLNCQTVQGYYYSKPLSSSEFEQFLKQ------
>tr|L8D6E9|L8D6E9_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudoalteromonas luteoviolacea B = ATCC 
------------------------------------------------------------------------FAQLMLSEQRLKSTVEGSGDTLWDWNIR
SGEIIRIND--NMAD-----APGKIFPNQ-HCIHPQDIPMVERLREHFAEKTAFFEASYRIRNSLKEWHWVLDKGKVIKDENLNPVRMTGIVRDISHLKT
TEERL----KCVESLSDAIAIYDAQFRLVDLNPSYLTLFGGIREQYHKP-------TLPGYDYIEELKLALKETEHWQEELKLSNVSNVMLPIEVTIDEI
KNNHGQITNYVVVFSDLTERKKAESQLHDLSNRDRTTGLPNRNLFFTNLKKLGQQ----GTHHALLVFDLDNFKKINDSLGHQLGDSLLAKLAMRLNKLA
RQQDTFYRLGGDEFALVMSGTNDHTITKTAKQFLAAIATPFKMASHELVITSSVGIVLFPEDGNTPEILLKNADTAMYHAKQKG-NHYLFFNDGMNEQAV
KRLQIENLMRYGLKEDHFVVYYQPKMDIKSGTLVGMEALVRFITPKKGIIPPNVFIPIAEETGQIIEIGEVVLDKACRDVKTWIDAGLFDGRVAVNLSAK
QFSLPDLTTRIDVILQKNQLPSYFLELEITEGTVMDDPQEAIAIMRSLSARGIHLAMDDFGTGYSSLAYLKQFPLNTLKVDKAFIDDMNSE-RGRNMVDS
IVTIAHNLELHVVAEGVESADQLSYLEALNCQTIQGYYYSKPLSYEEFTLFLRN------
>tr|V4I3V0|V4I3V0_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain protein OS=Pseudoalteromonas luteoviolacea 2ta16 GN=PL2TA16_04685 PE=4 SV=1
------------------------------------------------------------------------LDNLRMSEKWLKSTVEGSGDTLWDWNIQ
SGDIIRIND--ALNE-----EKNHFIPNA-KRIHPQDIPLVEKQKLHFAEKTAFFEASYRLRDNLNQYHWVLDKGKVIKDDNLNPLRMTGTVRDINHLKS
TEERL----KCVESLTDAIAIYDHNFKLVDLNPSYIRVFGGKRAQYESD-------QLPGYDFIRQIKSALKETEHWQEELKIYDQKGNMLPIEVTIDEI
KNSHGHVTNYVVVFSDLTERKKAESQLHNLSNRDRITGLPNRNLFFTNLKKLSQQ----GTHHALLVFDLDNFKKINDSLGHQLGDSLLSKLAMRLNKLC
RQQDTFYRLGGDEFALVMSGTNDHTITKVAKQFLAAIATPFKMANHELVITSSVGIVLFPEDGNTPEILLKNADTAMYHAKQKG-NHYLFFNDSMNEQAV
KRLQIENLMRFGLKEDHFVVYYQPKMDIRTGKLVGMEALVRFITPKKGIISPGVFIPIAEETGQIIEIGEVVLDKACKDVKRWVDKGLFNGRVAVNLSAK
QFSLPDLTARIDIILQKNQLPSYFLELEITEGTVMDDPQEAISIMRSLSSRGIHLAMDDFGTGYSSLAYLKQFPLNTLKVDKAFIDDMESE-RGRNMVDS
IVTIAHNLDLHVVAEGVEEEEQLTLLKQLECQTIQGYYYSKPLSSEEFERFLQA------
>tr|U1KU06|U1KU06_9GAMM Uncharacterized protein OS=Pseudoalteromonas rubra ATCC 29570 GN=PRUB_07080 PE=4 SV=1
------------------------------------------------------------------------LRALRHSEQRLKSTVEGSGDTLWDWNIR
SGEITRIND--MLDT-----TPTHLIPNA-SQIHPQDLPLVEKQKLHFAEKTAFFEATYRVKNSLEQYHWVLDKGKIIKDDNLNPLRMTGTIRDINHLKS
TEERL----KCVESLTDAIAIYDHTFRLVDLNPSYIRIFGGVREQYNTE-------KLPGYDFINQIKAALRKSEHWQEELKLYDQTGTMLPIEISIDEI
KNNHGHITNYVVVFSDLTERKKAESQLHNLSNRDRTTGLPNRNLFFTNLKKLVDQ----KRDHALLVFDLDNFKKINDSLGHQLGDSLLAKLAMRLNKLC
RQQDTFYRLGGDEFALVMSGTNDHTISKAAKQFLAVIATPFKMANHELVITSSVGIVLFPEDGSTPEILLKNADTAMYHAKQKG-NHYLFFNDSMNEQAV
KRLQIENLMRFGLKEDHFVVYYQPKMDIASGALVGMEALVRFITPKKGVISPGLFIPIAEETGQIVEIGEVVLDKACKDVKRWVDMGLFNGRVAVNLSAR
QFSLPDLTARIDLILQKNQLPSYFLELEITEGTVMDDPQEAISIMRSLSSRGIHLAMDDFGTGYSSLAYLKQFPLNTLKVDKAFVDDMNTE-RGCNMVDS
IVTIAHNLGLHVVAEGVEQEQQLHQLQRLNCQTIQGYYYAKPLSAEEFEQFLHA------
>tr|A4C679|A4C679_9GAMM Uncharacterized protein OS=Pseudoalteromonas tunicata D2 GN=PTD2_11724 PE=4 SV=1
------------------------------------------------------------------------QKKLQISEDRLKSSFLGSGDTLWDWNIV
TGELTRIND--FFEQ-----DKVTTPPNR-KNIHPQDLPKVELLKQHFSGHTAFFEASYRTKDNLGRWRWVLDRGKVITDPQLKPTRMTGTVKDISRIKS
TEERL----KCVENLSDAIAICDRNFNIIDINPSFLRFFGKQRDHYNKP-------KLHGYKYIEKLKTFLLDKGHWQEELKLPNENKELMPIDLSIDVV
KNSTGKVTHFVVLYSDISERKKAESELQRLSNRDRLTGLPNRNLFFTNLKKLGAQ----KCHHALLVFDLDNFKKINDSLGHQLGDMLLCRLANRLIKLT
RQQDSFYRLGGDEFALVIVGTNDHKITSTAKEFLHEITQPFHMAGHELVITSSVGVVLFPEDGNTPEILLKNADTAMYHAKQQG-NRYLFFNDTMNRQAV
KRLQIENLMRFGLKEDHFCVYYQPKMNTETNELVGMEALVRFITPNKGLISPAQFIPIAEETGQIIEIGEVVLDKACADVKRWLNKGLFSGRVAVNLSAK
QFALPDLTARIDAILQKHSLPSYFLELEITEGTVMDDPKEAIAIMKSLSARGIHLAMDDFGTGYSSLAYLKQFPLNTLKVDKAFIDDMSTE-RGRNMVDS
IVTIAHNLDLSVVAEGVEYAEQVHILSELNCETIQGYYYSKPLSAEHFEQFLEK------
>tr|U1KZS3|U1KZS3_9GAMM Uncharacterized protein OS=Pseudoalteromonas spongiae UST010723-006 GN=PSPO_17901 PE=4 SV=1
------------------------------------------------------------------------QLALKRSEHRFKNSILASGDAVWDWHIS
EHRLERIND--FNAI-----DHPDLPPNK-SNIHPSDLLHVEQIKKHLSGEISHFEASYRAKDANGDWRWVLDKGRVITDTDLKPLRMMGTVKDIGSVKQ
TQERL----NCIENLSDPIVIFDANFNIVEVNQAYLSYFGGTTANHGTP-------RLPGYDKTSQLYKAIQKKSHWHKELTFSKDKQ-STFFSLSIDRI
DNKKSNLRHYIAVYNDVTDNKQTELALQKLTNRDRLTGLPNRNQFFSNMKSLVGS----KNRHALLVFDLDNFKKINDSLGHHAGDILLCRLASRLSKRT
RERDQFYRLGGDEFALVMQNTNDHTITQAAKSFLALIEAPFHMSGHELVITSSVGIVLFPEDGNTPELLLKNADTAMYHAKQHG-NRYLFFNDAMNRQAV
KRLQIENLIRYGLKEDHFKVFYQPKMDINSGELVGMEALVRFITPNKGLISPAQFIPIAEETGQIVEVGEVVLEKACRDVKDWINRGLFDGRVAVNLSAK
QFMQPDLIGSIDKILKREGLASYYLELEITEGTIMEDPKDAIRIMNTLSARGIHLAIDDFGTGYSSLAYLKQFPLNTLKVDKAFIDDMGNE-KGKNMVDS
IVTIAHNLGLSVVAEGVEYEDQVEQLKELNCATVQGYFYSKPLSHEQFEQFLLA------
>tr|I1E1F7|I1E1F7_9GAMM Uncharacterized protein OS=Rheinheimera nanhaiensis E407-8 GN=RNAN_3149 PE=4 SV=1
------------------------------------------------------------------------QLKLEHSEERLRLSLWGSGDELWDWNIE
SGELYRSCSHPVVLQ-----PKADVPPNK-TQIHPQDIERVSQLQDHLSGKTAHFEATYRIKTSDNNWTWVLDRGKAVFSATGKPSRMTGTLKNIHQLKQ
TEEQL----KCLQTISDAVVICDTQFTILEVNPAFSRITGKSREQCQQR-------ELTLYPFMHDIRQTLAQQGSWHDEIKEQRLNGEIYQAELTFDQI
KDEQGQVTQYVAVFSDITERKLREAELSRLANSDTLTGLPNRAVFMQRLGQLVKA----GTEHALLVFDLDNFKKINDSLGHELGDNLLCKLAQRLSSYA
QYASRLYRLGGDEFALLLDNTNDLHITSVAKELLNLINQPILVEQQELAITSSVGIVLFPDDGVDPQALLRNADTAMYHAKSQGANRYLFFNDSMNKQAV
KRLQLENLIRHGLKEDYFAVYYQPKMNIVSGQLAGVEALVRFITPKGGVISPASFIPVAEETGQIIEIGEVVLRKACQAVKGWIDQGLFHGRVAVNLSSR
QFSLPFLCEQIDEILQQTELPSYHLELEITEGTVMQSPPQAIDTMKKLRARGIHLAMDDFGTGYSSLAYLKQFPLNTLKIDKAFIDDMKSA-RGRNMVDT
IMTIAHNLSLSVVAEGVEQPEQLQQLSKLRCDVIQGYYYSKPLSAQELTQFLQQ------
>tr|F7NT70|F7NT70_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Rheinheimera sp. A13L GN=Rhein_0960 PE=4 SV=1
------------------------------------------------------------------------QSKLEQSEERLRLSLWGSGDELWDWDML
EGQLYRSSSQPLEKP-----GDQQFPPNR-SEIHPQDVERVTSSQQHMHGMTPIFEASYRIKAANGQWVWVLDRGKVVLNEQGQAIRMTGTLKNIQQLKE
TEERL----RCLDNISDAVMVCDTNFALLEVNPAFVSMTGKSRESVHSV-------ELCLYPFLHEIRQALLEQGYWAGEIEDKRHNGELFQAELSFDVI
RDELGQVQQFVGVVSDISERKKREAELNRLADTDTLTGLPNRARFSSHLTQLVRE----QVEHALLVFDLDNFKKINDSLGHELGDTLLCKLSERLSLFT
RFKAKLYRLGGDEFAVVLENTNDHSITSLAKDLLKQINLPFFIEQHELAITSSIGIVLYPEDGHDPQALLRNADTAMYHAKHEGANRYLFFNDSMNKLAV
KRLQVENLIRHGLKEDYFTVFYQPKMDIVTGQLVGMEALVRFITPKKGLISPASFIPVAEETGQILEIGEVVLQKTCEDVKRWIDMGLFHGRVAVNLSAK
QFMLPFLCEQIDDILQRSELPSYHLELEITEGTVMQSPTLAIDTMKKLRARGIHLAMDDFGTGYSSLAYLKQFPLNTLKIDKAFIDDMNTA-RGRNMVDT
IVTIAHNLNLTVVAEGVEQAEQLQQLKQLRCEIIQGYFYSKPLSAHDFGLFLKQ------
>tr|H3ZB43|H3ZB43_9ALTE Uncharacterized protein OS=Alishewanella jeotgali KCTC 22429 GN=AJE_02741 PE=4 SV=1
------------------------------------------------------------------------HQALAKSEERLRLSIWGSGDELWDWNID
SGELYRSSAEPLAIA-----PQEDFPPNK-ALIHPQDLERVSHASQHLAGKSPFFEASYRVKTVDDTYIWVLDRGKVVFHEDGKPQRMTGTLKNISQLKQ
AEARM----RCLENISDAVVICDTKFSIIEVNPAFSVITGKSREQVQNR-------QLSLYPFIQEIEKKLVKDGRWSGEIRELKTNGDYYQAELTFDVI
KDDQGCITQYVAVFSDISDRKRREAELSRLANSDTLTGLPNRAVFMNKLASLVTE----KTEHALLVFDLDNFKKINDSLGHELGDALLCKLADRLHNNK
LFRQKLYRLGGDEFAILLDNTNDHAITSLAKNLLEQINKPFAVDQHELAVTSSVGIVLFPEDGKDPQALLRNADTAMYHAKSAGANRYLFFNDTMNKQAV
KRLQIENLIRHGLKEDYFTVFYQPKMDMLSGKVVGMEALVRFITPKGGLVSPASFIPVAEETGQIVDIGTVVLRKACIDVKRWIAQGLFHGRVAVNLSAK
QFMLPFLCDQIDDILQQTDLPSYHLELEITEGTVMQSPKLAIDTMKKLRARGIHLAMDDFGTGYSSLAYLKQFPLNTLKIDKAFIDDMSSA-RGRNMVDT
IVTIAHNLSLSVVAEGVETHEQLEQLRKLRCEIIQGYYYSKPLSAEDFAAFLQE------
>tr|F8E9Q7|F8E9Q7_FLESM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Flexistipes sinusarabici (strain DSM 4947 / MAS 10) GN=Flexsi_0
------------------------------------------------------------------------------------ISL--NNSSFVNLNIS
SRIISESEKRSLFENIMDVQFCINEKGEL-ILISPSGVGLLNYR----EILYKNFSSKLLYDE--AYQDLV-------KKKNGRLV-IEGIFRDITERKN
NEKQL----SVFENTIESIMIVSSDGKIQKINQAFLDSTGYSEEEIVDFSPLEIQPFNENRRYLLKVAAEVRKNDRWKGEIWCRKKTGEIFPQWMSVSVL
KDDSGNVMNYILLLHDITSLKKSEEELRHQATHDMLTGLPNRQLFEDRLKRAVAHHERYGGKFALLFIDLDNFKNINDTLGHKIGDLLLVKAGETLLECC
RESDTVARLGGDEFTIILNDIEDNGIVAVTEKILKAVASAKKVGGHEVYTSASIGIAVYPADGRNSVSLIKNADMAMYKAKELGANDYYFYNSDLKVRLE
RKISLTTKLAKALEENDIKVYFQPLIDLKSGKITGAEALARWQTDTSRFIRPDEFIEAAEESGLIGTLGDHVLNKSCENLRKWHDAGFENLTMSVNLSVK
QMNDQNLVTKTKNALKKYSLKPTDLVYEITENVAMKDFDATLALFKELSGLGVKISMDDFGTGYSSLAYLKQFPLNSIKIDKVFLQNIPENEKDNNLIKG
IVWMAKSLGLNVVAEGVENKFQSEFLREIGCNGCQGYYYSRPLPEDEFFDYLKA------
>tr|D2UCH8|D2UCH8_XANAP Uncharacterized protein OS=Xanthomonas albilineans (strain GPE PC73 / CFBP 7063) GN=XALc_0787 PE=4 SV=1
------------------------------------------------------------------------YEELQQHEHYLKLALWASGEHFWDYDLQ
NRTLRRMRADDANPHLQD-IALVIHEDDP-LRIHPDDIQQAKLASEHLEGLTAIYLAEYRVDLGDGVWRWARVRGR--YDAVGNPRRLAGTARDITSHRQ
ADLER----EVLRSMSEAVAVLDEERRFISVNPAFTRITGYSEREVLGQPMTLIDHAPNVPP-----PPMLDQGRHWRGDAWKRRKDGHEILCHMRRNTV
VDADGRQSFQVVVLEDITEQKRAEQELRYLANYDTLTSLPNRALLSERLARAIVRARRQAGAVAVLFLDLDRFKDINDSQGHPVGDQVLRAVAERLQQAV
GPQHTVARLAGDEFTVVVEDIVSDEAESVAARVLAAFEPPLRLDRREVAVSTSIGISLFPQHALLPSELLKHADTAMYQAKAAGRRNAQVYSASMDEATR
HRATLASTLRKIPLDQELKLVYQPRYSLREQRVVSVEALLRWHSADFGPVSPSQFIPLAEETGLILQIGEWVLRQACSALRDWRQMGLTDLCMSINVSAI
QLERSNLPELMAQILAETGVPAANVELELTESVVMSQVGKSAEILHACRELGLTLAIDDFGTGYSSLAYLKRLPINTLKIDQAFISDLSLDPDDASITST
IIAMGHSLDLKVVAEGVEQPSQLMFLREHGCDEIQGHLVAPALEPDACLKLLQQ------
>tr|A0A0A8DZV8|A0A0A8DZV8_9XANT Sensor protein OS=Xanthomonas sacchari GN=SB85_17545 PE=4 SV=1
------------------------------------------------------------------------HAQLQQRDQHLKLALWASGEHFWDYDLQ
QRRLRLMRADEATPHAQD-IGLVIRENEP-LRIHPDDVQQARQVQEHLQGLTAIYTAEYRVDLGDGVWHWARVRGR--YDASGAPRRLAGTARDITSHRQ
ADLER----EVLRSMGEAVAVLDEDRRFISVNPAFTRITGYSEREVLGQPMALIDHAPETPA-----APVADHGRHWRGEAWKRRKDGQEILCHLRRNTV
VDADGRQSFQVVVLEDITEQKRAEQELRYLANYDTLTSLPNRALLSERLARAIVRARRQAGSVAVLFLDLDRFKDINDSLGHAIGDRVLRAVAERLQQAV
GPQHTVARLAGDEFTVVVEDIVSGEAEAVAARVLAAFEAPLRLDRREVAVSTSIGISLFPQHALLPSELLKHADTAMYQAKAAGRRNAQVYSARMDEATR
HRATLASTLRKIPLDQELKLVYQPRYSLRTQRVVGVEALLRWHSADFGPVSPSQFIPLAEETGLILEIGEWVLRQACGALRDWRRMGLTDLCMSVNVSAI
QLERGNLPELMAGILAETGVPAANIELELTESVVMSQVGKNAELLRACRKLGLTLAIDDFGTGYSSLAYLKRLPINTLKIDQEFIGDLTRDPDDEAITST
IIAMGHSLALKVVAEGVEDAGQLAFLRAHGCDEIQGHLVAPALEPDACLRLLQQ------
>tr|L7G8I7|L7G8I7_XANCT Two-component system sensor protein OS=Xanthomonas translucens DAR61454 GN=A989_15697 PE=4 SV=1
------------------------------------------------------------------------QQQLQQRDRHLKLALWASGEHFWDYDLQ
QRKLRRMRADEAAPHAQE-ITMVIREDDP-LRIHPDDVPQAERAREHLRGLTPVYVAEYRVDLGDGVWLWARVRGR--YSADGKPRRLAGTARDITSHRQ
ADLER----EVLRSMSEAVAVLDEDFRFISVNPAFTRITGYSEREVLGQPMTLLDHAPETPA-----PPSHDRGRPWRGEAWKRRKDGLEILCHVRRNTV
VDADRRHSFHVVVLEDITDQKRAEQELRYLANYDTLTSLPNRALLSERLARAIVRARRQGTAVAVLFLDLDRFKDINDSLGHAVGDRVLRAVAERLQQAV
GPQHTVARLAGDEFTVVVEDIADAEAEAVAARVLAAFDAPLQLEGREVAISSSIGISLFPQHALLPSELLKHADTAMYQAKGAGRRNAQVYSARMDQATR
HRATLASTLRKIPLDQELKLVYQPRYSLREQRVVGVEALLRWHSADFGTVSPSQFIPLAEETGLILEIGEWVLRQACTTLRGWRELGLTALCMSVNVSAI
QLERGDLPALMARILDETGVPAANVELELTESVVMSQVGKNAATLHACRALGLALAIDDFGTGYSSLAYLKRLPINTLKIDQEFISDLTRDPDDEAITST
IIAMGHSLALNVVAEGVEQPGQLAFLRQHGCDEIQGHLVAPALEPEACLQLLRQ------
>tr|G7UTA8|G7UTA8_PSEUP Two-component system sensor protein OS=Pseudoxanthomonas spadix (strain BD-a59) GN=DSC_13550 PE=4 SV=1
------------------------------------------------------------------------AAPVREADDHLKLALWGSGEVFWDYDLI
GRRMHQMRADEQSPSSNA-ITMLTGVGQM-PAIHPQDLPLVVQRRSHLRGDAPQFTSEHRMDMGDGTWSWVRARGR--SDASGRALRLAGTARDITASRN
AEYEH----QVMRSMSEAVAVLDSEYRFITVNPSFSRMTGYDGAEVAGQPLSLLDGRQHPGDGAAGMSAQLQREGRWSGEAWKVRKDGEEILCRIEANMV
PDASEQRLMVVLVLNDITEHKRVEQELRYLANYDTLTSLPNRSLLFERLARAVVRARRERSRVAVLFIDLDRFKDINDSLGHATGDRILRAAAARVQQTV
GTQHTVARLSGDEFTVVLEGIASADAERVAERIIQAFTQPLSFGRLELAVSPSIGISLYPDHAQVPTELLKHADTAMYQAKAAGRHTWAVYSEAMDEKTR
HRAILASALRRALERDELRVVYQPRLSLANNRITGTEALLRWDSHELGEISPAQFIPLAEESGLIVDIGIWTLRQACQTLRQWHAAGLDHLNVAVNVSSL
QLQRGDLADVVARVLAETGIDASLLELELTESVLMANPDHASGVLRDCRALGVSIAIDDFGTGYSSLAYLKRLPLNTLKIDQAFVRDIDHDLEDEAITSA
IIAMARSLDLKVVAEGVETSAQLAFLRQRGCEEVQGHHVSRALEPAQCMAFIRD------
>tr|A0A091AUT3|A0A091AUT3_9GAMM Uncharacterized protein OS=Arenimonas oryziterrae DSM 21050 = YC6267 GN=N789_11630 PE=4 SV=1
------------------------------------------------------------------------LAEIREREARLNLALWGSGDEFWDWNIR
ENSVYRLGASQLLGQGSM-DSMSTDDWRT-HSIHPDDLPRVQKLQEHIVGHSELYESEHRIR-VRGEWIWVRARGK--RDAGGSPLRLAGTARDITLIRR
AERER----EVLRSMSEAVGVIDLDFRFISVNPAFSRITGYSEEEVVGQNSRLLDSSQHSSDFYRRVRDILERTGHWAGEMWQKRKDSEEFLGWIEMSEV
RDAQGMRSHFVAVVNDITDKKRAEQELRYLANYDTLTGLPNRALLSERLGRAIVRARRQETRVAVLFLDLDRFKDINDSLGHAAGDRLLKAAATRLQATV
SASDTVARLGGDEFTVVLEDVESPAVERMAREILNAFSMPLEVDRHDVSITPSLGISLYPDHALVPTDLLKFADTAMYQAKAEGRNTYQIYNETMDAESR
RRATVLASLRKALDRGEFRLVFQPRMALADGRITGVEALLRWHSAELGEISPVVFIPLAEESGLILPIGEWVLEEACQTLKRWRNHGLTELSIGINVSVL
QLLRSNLPEHLTQVIEDTGVPANRIELEVTESMVMQNAEQTTNVLNELRKIGVSLAIDDFGTGYSSLVYLKRLPIDTLKIDKEFIGDLTRDPDDEAITAT
VITMGHSLGLNVIAEGVETEQQLSYLREQGCDEIQGFWLSPPLDSHRCLAFIRS------
>tr|A0A0D0S210|A0A0D0S210_9GAMM NODE_4, whole genome shotgun sequence OS=Lysobacter sp. A03 GN=TI01_0749 PE=4 SV=1
------------------------------------------------------------------------ENRIEEHDERLKLALWASGEQFWDYDLA
AQELHHTRVSTSSLDQPE-VTVERYALDE-LTIHPDDLHQVQDARQHLRGATPIFSSEYRTRREEHSWCWVRARGK--RGPDGRASRVAGTVRNVTDSRS
AEHER----EVLRSMDEAVAVFDRDFRFISVNPAFTRITGHDPGDVLERSTSVLDSSRHDIEFHRRLRHDLLRDGRWSGELWMRRRDGDEFLCLLRISSV
GERDGRRSHYIAVLNDITEKKRAEQELRYLANYDPLTGLPNRSLLLERIAAAIVRARANNTRIGVLFVDLDRFKDINDSLGHGIGDRILRAVATRLHAFA
GPQQTAARLSGDEFMLVLENITSEEATTASQRLIAAFESPVTFGSQEVIISPSIGISVYPDDAQIASELIRQADTAMYRAKAVGRRTSMRYEAAMDVDVQ
RRATLSAALRTVLDRNELSLAYQPRLSLVSNQIAGVEALLRWHSPEHGQIHPVQFIPLAEETGMILEIGEWALTEACRALATWRDAGLVDLPIAVNVSSL
QLLRGDFPQVVERVLAQTGIPANRLELELTESLLMDNRAEASISLQQFRRIGVNLAIDDFGTGYSSLAYLKRLPITMLKIDKEFIDDLAENTDDAAITTT
IIAMGHSLGLTVVAEGVETNTQAQWLREHGCDEIQGYWLAEPMPAAELTKFVQG------
>tr|Q1N3N5|Q1N3N5_9GAMM Sensory box protein OS=Bermanella marisrubri GN=RED65_12239 PE=4 SV=1
------------------------------------------------------------------------EDAVKKSEERHRLAMKSSGTRIWDWDVK
QQKFYFSPDLVEELGYDGQRLEYNVDDFY-NIVHPDDLKAIEKAIRQHFKYNTPYHLNYRLRHDGHYFLYE-NIGQAIRNQDNLVQRFIGSSKNLSTQKA
LNEQA----LVFDNSGEGILIADAHRVIKAVNSAYCYISGYEQHEVIGLESDFLLKENPLDEKQRDIFKSIQRNGYWRGETWYKHKEGHAIAIEMMINTQ
KNSNNEIENYIVLFSDITDKKQTQELIWQQAHYDNLTQLLNRHSFTQYTQNLIQK----ALPFALLFIDLDNFKQVNDTQGHNVGDALLIEAAKRIKQCV
RESDIVARFGGDEFTVLLLGIKNLSTKRICSDITKRLSEPFTLDKEKAYVSASIGIAQFPWDSDNLEDLYKYADQAMYEAKHLGRNRFSFFTHELQQKAS
ERQRISLDLRQALERNEFQVYYQPIVDLKSHQVHKAEALIRWHHPRDGIISPADFIPIAEESGLIIEIGNWIFKQAAMQTKLWRKTLYPDFQISINKSPV
QFYGEDIHQSWSQFLQIINLPGDGISVEITEGLLLDSIPIVKEKLSDFSQSGIQVSLDDFGTGYSALSYLKKFNIDYIKIDMSFVRNIVNDKYDLILCET
IIAWHINSV---------------------------------------------------
>tr|W8KFU8|W8KFU8_HALHR Diguanylate cyclase OS=Halorhodospira halochloris str. A GN=M911_04845 PE=4 SV=1
----------------------------------------------------------------------------------LWEAVQGGNVGLFEWRPD
-GSVILSRELKGQLGYLDHQLHNDMEAWR-SLIHPDERDEDIRLQYTRRPKG-RFRIEVRMRHRTGGWRWILYQASPVYGPDGCLSKILGSSVDVTERKL
AEEQS----YAVEQSPSVMILTNTDGVIEYVNQRFCDNTGFSRDEVLGKRPGMLRYGETNSEKSHQLWTTIQSGKTWEGEFHNRKRSGEPYWEQARISPI
RNARGEVTHYIKLAEDISDKRALNERLEYLAFHDPLTGLPNRSLILDRIGQAVAQAHRDQHALAVMFIDLDDFKVINDSLGHDLGDQLLIQVAHRLRSLL
RQGDTVARFGGDSFILLLPKLSHEDAIPVLEKIQKVLNQPIPLSSQQVSVTVSIGISIHPGDSDRPEDLIRHADAAMYRAKAEGRRCYHFYTPEMDAALQ
ERMELDQSMRQALERGEFHLVYQPRVDLASGRVLSLEALVRWHHPQWGMISPGRFIPLAEETGFILSLGPEVLRQACEQIRAWKARGVPTVTVAVNLSAR
ELREPDVVDRILGVLADTGLEASDLEIEITESAAMSSIEQTIRTLTELNTQGVRISIDDFGTAYSSLNYLKRLPVHAIKIDQSFVSEMKDDPEDAAIIRA
IIGLGETLGLKVIAEGIENTLQRDFLLDHGCVQGQGYLYSRPVPAEDVERLLNP------
>tr|W8KWJ9|W8KWJ9_HALHR Diguanylate cyclase OS=Halorhodospira halochloris str. A GN=M911_13220 PE=4 SV=1
----------------------------------------------------------------------------------LQEAIQAGNIGLFDWDLH
TQKVFYSREWKQQLGHEDREIGNSYEEWS-TRLHPEDRQASEQREFLANPRG-RLVYETRMRHKDGSYRWILAQASLIRGADGLPARMVGSHLDITERHA
TEESL----FAVDQSPSIVVITDTQGHIQYVNHQFCNVTGFSLKDVSGLSAQDLGSTHPPGIEDSRVFSILSEAGLWEGQFRNVKKNGEVYWEQACIYPI
RNTQGEITHYIKLAEDITDKKQLSERLDFLAFHDPLTGLPNRELLIDRLTQAMAMARRDRHVLAVAFLDLDDFKVINDSLGHEQGDALLVQVSQRLREHL
REGDTVARFGGDEFLLLLSNLHKQDLIPVVEHLQEAFSQPFTLGDTPVVISFSIGMAVFPHDSERPEELIRHADAAMHRAKTQGRRSYNFYTRELDEQLQ
DRMQLEQAMRQGLENQEFFLCYQPRVELSTGRIISLEALVRWNHPQWGLVSPGRFIPLAEETGFILALGPEVLRLACLQIRQWDEQGMPAVPVAINLSAR
EFHQPDILERTLTILEQTGVEPARIEFEITESAAMSSVERTIETLALMNARGFHFSIDDFGTAYSSLNYLKRLPVQAVKIDQSFVLDLEDNPEDSAIIRA
IIGLGHTLGLEVIAEGVETPAQRDFLIRHDCQVGQGFLFSPAVPGEQIRSMMLK------
>tr|H1G4T0|H1G4T0_9GAMM PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Ectothiorhodospira sp. PHS-1 GN=ECTPHS_09003 PE=4 SV=1
----------------------------------------------------------------------------------LQEAIKGGRIGLFDWDLQ
TGEVYYSPEWKTQLGYTQEEIGSDYTTWL-ALLHPDDREATERQEYLKCADGRRYVMEFRMRHRDGSYRWILAQGSLIHGPDGRPSHMVGSHLDITERRR
TEGHL----FAVDQSPSIVVITDPDGAIQYVNRRFCEVTGFAPEEMLGVNARALAQTPIEEVIHQNLVFTLRQGHTWEGEFRNRKKSGETYWEQARIYPV
REEDGTIVQYIKLAEDITDRKQLTDRLDFLAFHDTLTGLPNRSLMMDRLGQALVQARRDKTLLAVAFLDLDDFKTVNDSLGHGQGDQLLRMVAERLKGLL
REGDTVARFGGDEFILMLTQLHARDVIPVVEKLQMAFTQPITLGQTPLVTGFSIGLAIYPTDSHRAEDLIRHADIALSRAKAQGPRSYHFYTRDLDDQLH
ERMQLEQAMRCGLEQGQFLLHYQPCMDMRNNRMLSMEALIRWQHPDWGMVMPGRFIPLAEETGLIIELGSEVLRLACLQLKAWQSSGRPLLPLAVNLSPR
EFHQSDLLERIMGIMEEYEVDTRLIEFEITESAAMSSVEQTIDTLSQLTRMGFRISIDDFGTAYSSLNYLKRLPVQSLKIDQSFVRDLADDPQDAAIIRA
IIGLAGNLGLEVIAEGVETSAQREFLLKHGCRVGQGYLFSRPVAAADIETRFAA------
>tr|A0A067ADA2|A0A067ADA2_9PSED Diguanylate cyclase domain protein OS=Pseudomonas sp. P482 GN=BV82_1894 PE=4 SV=1
------------------------------------------------------------------------FRRSNG-----QVFTGLTSAETFQLDST
PRDISQLKETQ--EQLQT---SEEKFAKA-FHASPDGLLLSRQSVNEGFCRLTGYDTHMSLDHSLDLGIWVDLNER--RRSDGRPLPMLTIARDITERHL
MQEKL----TVFENTAEGVLITDTDQRISAVNRAFSEITGYSEFEALGQTPRLLASGQHDSAFYVAMWHQLTAEGHWQGEIHNRRKNGEVYPSWLTISAV
RSSERGITHFVAVFADISSLKHAQAKLDYQAHHDPLTGLPNRTLFESRLQAAINCAQASQRQGAVLFLDLDRFKHINDSLGHPVGDLLLKAIAQRLKDQV
RDIDTVARLGGDEFIILLPGLHQSDAGHIAHKLLACFGAPFQAGEHEFFTSASIGTSLYPQDGTDVASLIRNADAAMYRSKAKGRNRVESYTRDLTAQAS
ERIALEHELRRAIERNELSLCYQPKFSLKTQSLVGAEALIRWTHPSFGDVPPEHFIPLAEENGMILQLGDWVLEQACQQMQAWKHDYLAFGPLSVNLAGA
QLRQPSLVKRIEQLLKTHQLKAGDLQLEITENFIMSQAEEALAILHQLKQLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFIRGLPDDPHDAAIARA
IIALGRSMQLTIIAEGVESQAQQQFLAAEGCEQIQGYIVSLPLPAGEFAATFLR------
>tr|H0J093|H0J093_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halomonas sp. GFAJ-1 GN=M
------------------------------------------------------------------------VSRHVGLPGGINVTLHAYPGEHYNWYMV
GVIVSMSRTKELFLARESLEQSEQHYRSL-FTHHPDAVFS-LNAANNSCGAITGYANADII--GQHFTHFIEGADVERRDRDGLPISIAQ---DVTASRE
QQTRL----RGVEASVNGVLIADADTPVVYANKAFTAITGYSQEDVIGHNCRFLQGPDSDPEVVAQLRRGIKERR-VHVTICNYRQDGTPFWNDLYIAPV
RDQEGQVTHFVGIQHDISQQKASEARLSYYASHDDLTRLPNRMLFEETLCKQFALANMHHQRISVLFVDLDDFKPINDSLGHAVGDQVLVEVAQRLRDTL
RQEDTVARLGGDEFVLLLTNTPHAQAEEVVERLLPALSKPYCIDGRELHLSASVGIAMSQPDTPQPQTLIQQADIAMYRAKQQGRNAYAWFHHNSHDIAS
ERVTLRNDLQEAIERQAFELYYQPIFNR-DGQVASLEALLRWPHPTQGYISPDRFIPLAEATGQIMPISEWVLNRACTDMQQLNDKGLGAKCVAVNLSPL
QFHRASFLETLSATLMDTGMPSAQLTLELTEGILMDNTANAIDILHSVRSMGIKVSIDDFGTGFSSLSYLKHLPISTVKIDRSFIKELTHSDDDAAIVQG
IISMAHHLGLKVVAEGVETDEQHQRLLTYQCDFFQGFGLARPMPLSALEQLMTA------
>tr|W9TWU7|W9TWU7_9PSED Sensory box/GGDEF family protein OS=Pseudomonas sp. BAY1663 GN=BAY1663_00418 PE=4 SV=1
------------------------------------------------------------------------VNNLEGMAYRCLN------NGQWTM-IF
V-------GCLGLCGYSAAELVDTMVSWE-QITHPDDRARVRRSVETAIDGLGRFTVQYRIRTAAGYFKWVMERGVAVPDEQG----IEGFIEDITGQKA
VLEALEQAESIFENASEGIFQSTRDGRYLAANPALARIYGYDTATAVAD-LADIERVEGGRRFCRLME----QQGELNFESEVYRRDGTRIWISENAHVV
HGANGEFICYEGTVQDISERKHYQQQLERQANHDLLTGLPNRILLNDRIEQGLARAARLGYYLPLVFIDLDNFKFINDGLGHVAGDELLKSIAKRLAGSL
RSSDTVARVGGDEFVLVLNDHYRSTVISLLERMLNEIRRPVTLAGREFQVGASLGVAMFPDDGEDAQSLLKHADIAMYAAKKRGRNNFQFFTHDLNRIAD
ERLNLEAAMRLALEGDEFTVHYQPKVD-AACRIVGVEALARWTHAGLGVVGPDRFIPIAEESGLIMPLTLAILRRAFSAARRWNEGRATPLLVAVNLSPL
LFLGDDIVERIAALLEEIGLSPALVELEITETVFLGDGARAVAILTEFKALGFRLAMDDFGTGYSSLSYLRRFPLDIIKIDRSLVTGLEHEDEVAMIARA
AISLGKSLRKTVVAEGVENRAQFEFLCRQGCDEFQGFLLSRPLPEAQVTALLAA------
>tr|V4Q886|V4Q886_PSECO Diguanylate cyclase OS=Pseudomonas chloritidismutans AW-1 GN=F753_18305 PE=4 SV=1
------------------------------------------------------------------------VNNLEGMAYRCRN------DAPWTM-IF
V-------GSQGLCGYSAADLVDNGISWD-RITHPDDRLRVRRCIDNAVAGMGRFTVHYRIRTAAGNLKWVIERGVAVPDEQG----VEGFIEDITAQKA
VLEALEQAESIFENASEGIFQSTRDGRYLAANPALARIYGYDSASEVAD-LADIERVEGGRRFCQLME----QQGELNFESEVYRRDGTRIWISENAHVV
RGASGEFICYEGTVQDISERKHYQQQLERQANHDLLTGLPNRILLNDRIEQGLARAARLGYYLTLVFIDLDNFKFINDGLGHVAGDELLKSIAARLAGSL
RSSDTVARVGGDEFVLVLSDHYRSTVISLLERVLNEIRRPVMLAGREFQVGASLGVAMFPDDGEDAQSLLKHADIAMYAAKKRGRNNFQFFTHDLNRIAD
ERLNLEAAMRVALERNELSVHYQPKVD-ATRRIVGVEALARWTHAELGVIGPDRFIPVAEESGLIMPLTLAILRRAFTDARQWNEGRATPLLIAVNLSPL
LFLGDDVVERILAVLDEIGLPPTQVELEITETVFLGDGTRAVSILAEFKARGFRLAMDDFGTGYSALSYLRRFPLDIIKIDRSLVTGLEQEEEVAMIARA
AISLGKSLHKTVVAEGVENAAQFDFLRRNGCDEFQGYLLSRPLPAAQITALLAD------
>tr|A0A061JV00|A0A061JV00_PSEST Diguanylate cyclase OS=Pseudomonas stutzeri KOS6 GN=B597_004020 PE=4 SV=1
------------------------------------------------------------------------IHNLEGMAFRCRN------DASWTM-IF
V-------GALGLCGYSAAELVATRISWE-QITHPDDRLRVRHCIEAAIAGCGRFSVQYRISTAMGSLKWVIERGVAVPDEQG----VEGFIEDISPQRA
VLDALEQAESIFENASEGIFQSTRDGRYLAANPALARIYGYDSATEVAD-LADIERVQHGRRFCLLME----EQGELNFESEVYRRDGARIWISENAHVV
RGANGEFICYEGTVQDISERKHYQQQLERQANHDLLTGLPNRVLLNDRIDQGLARAARLGYYLTLVFIDLDNFKFINDGLGHVAGDELLKSIAARLASSL
RGSDTVARVGGDEFVLVLSDHYRSTVISLLERVLNEIRRPVALSGREFQVGASLGVAMFPDDGDDAQSLLKHADIAMYAAKKRGRNNFQFFTPELNRIAD
ERLNLEAAMRVALERDEFAVHYQPKVD-ASCRIVGVEALARWTHSELGVIGPDRFIPVAEESGLIMPLTLAVLRRAFSDARRWNEDRDTPLLVAVNLSPL
LFLGDDVVERVAAVLNAVGLPATQVELEITETLFLGDDTRAVTILAEFKALGFRLAMDDFGTGYSSLSYLRRFPLDIIKIDRSLVTGLEQEEEVAMIARA
AISLGKSLHKTVVAEGVENQLQFDYLCDHGCDEFQGYLLSRPLPAAQLTALLDA------
>tr|N6Y5Z8|N6Y5Z8_9RHOO Sensory box/GGDEF family protein OS=Thauera sp. 63 GN=C664_17150 PE=4 SV=1
------------------------------------------------------------------------VNNLDGMAYRCHL------DHDWTM-VF
V-------GCLALTGYPADVLVANALSWE-AVTDPSDRQRVRGEIEAAVRSARRFAVEYRIRTREGDTKWVLERGIPVPDERG----IEGFVEDITEHRA
MVAALEHAEHIFEHASEGIFQTTPEGRYLAANPALAKLYGYAGPDEIAD-LAELDRVEPGRRFRRLME----THGERNFESEVYRRDGSRIWISENAHIV
RGSDGRLICYEGTVQDVSERRHYEAQLERQANRDQLTGLPNRNLLRDRIEQGIARAARRGCMLALVFIDLDGFKFINDSLGHAAGDELLVEIAGRLNASI
RSSDTVGRLGGDEFVLVLNDHEQGSVISTLERVLQDIGRPAALAGRELQVGASLGVAMYPDDGDDADSLLKHADVAMYAAKSRGRNNFQFFTRALNSVAE
ERLTLEAAMRVAIERDEFEVHYQPKLD-HRRRIVGMEALARWFHPVLGDIRPDRFIPIAEECGLILPLTTCILRRAFAAARRWNQGRDQPLRLAVNLSPR
LFLSRDIVAHVSGLLCDAGLPASQVELEVTETVFLGDDELAVGIFRAFKALGLSLAMDDFGTGYSSLSYLRRFPLDTIKIDRSLVVGIEQQDEMAMIARA
VISLGQSLRKTVVAEGVENPAQFDFLRFQGCDEFQGYLFSRPLPEAGFARLLEA------
>tr|A0A016XG49|A0A016XG49_9BURK Diguanylate cyclase OS=Hylemonella gracilis str. Niagara R GN=AZ34_03250 PE=4 SV=1
------------------------------------------------------------------------INNLDGMAYRCLN------DAQWTM-VF
V-------GCLALTGYTPQELVNTAVSWE-QITHPLDRERVRNSVATTSANNLRFAVDYRIVTKDGTVKWVNERGVAVADEQG----IEGFIEDVTAQRE
LAEAQQAAEHIFEHASEGIFQSSPEGHYLAVNPALARLYGYASPEAISG-LANISRVKEGQRFRQMMA----EQGELNFESEVYRADGSRIWISENAHTV
CDAGGKLLYYEGTVQDISERRRYQQELEHQANHDTLTGLPNRMLLSDRVEQGIARAERLGYHLVVVFIDLDHFKFINDSLGHDAGDELLKEVALRLRRCL
RASDTVARLGGDEFVLLLADHFRSTVIDQLQRVLGEIARPVQLSGREFQVGASLGVAMYPGDGEDALALFKHADAAMYAAKGAGRNNFQFFTRELNHVAT
ERLHLEAALRHAIDHEGFDVHYQPKTD-AQRRIIGMEALARWRPPEYGPISPDRFVPIAEDSGLILPLTMTILQRAFIATKRWNEGRDNPLRIAVNLSPR
LFLSDDIVGHVHRLLREADLPPELVELEITETVFMSRSERVLETLILFKQLGMQLAMDDFGTGYSALSYLRRFPLDIIKIDRSLVTGIEREEEVAMIARA
VLSLGQSLHKTVVAEGVENQAQFDFLRSQGCDEFQGYLLSRPLDEAGMTALLQA------
>tr|A0A0C5J8U6|A0A0C5J8U6_9RHOO Uncharacterized protein OS=Rhodocyclaceae bacterium PG1-Ca6 GN=PG1C_07865 PE=4 SV=1
------------------------------------------------------------------------MANLNGMAYRCRL------DAQWTM-RF
V-------GCLDLTGYAPEALVNKRLSWE-DITLADDRLRVREEISAAVAANRHFAVEYRILTCAGQEKWVLERGMAVLDECG----LEGFIEDVSERRQ
ALDAVANAEHIFEHASEGIFQTTPDGHYLSANMSLARLYGYTSPEEIAD-LADIERVDPVQRFRCLMD----AHGEVNFESEVYRRDGSKIWISENAHSV
RGLQGELICYEGTVQDITERRSYQEQLERQANFDQLTGLPNRNLLNDRLEQAISRAARRGYFLALVFIDLDNFKFINDSLGHVAGDELLVEVAHRLRNCL
RTVDTVARQGGDEFVLVLNDHYQASIISLLERILQEISRSITLMGRDWQVGASLGVALYPTDGEDTPTLLKHADVAMYAAKARGRNNFQFFTHEMNRISD
ERLRLEAAMRVALEQDGFSIAFQPKVD-HRRRIVGAEALARWHTKDFGTVPPDCFIPIAEETGLIVPLTEIILRKAFAAASKWSQTPGHAITVAVNLSPR
LFLDGKIVEHVARLISEAGLPPEHVELEITESIFLGDSGRTLSILKGLKQLGVALVMDDFGTGYSSLSYIRRFPLDIIKIDKSLVTGIEYEDDGAMIARA
IISLCQSLRKTVVAEGLENQAQFDFLRYQGCDEFQGYLISKPLPEQEFADLLIA------
>tr|H0PXI7|H0PXI7_9RHOO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Azoarcus sp. KH32C GN=AZKH_0842 PE=4 SV=1
------------------------------------------------------------------------IDNLDGMVCRCAI------DRHWTM-LF
V-------GCRRLLGYSPEELINRYVSYE-ALTHPDDREHVRREIVAALAAGVRYRIEYRVVCRDGSIKWVLERGVGVQDESG----VECFIEDITDQVE
AQQRLAETESLFENAVVGIFQTSADGQYLAANTALARMYGYTTVDEMAG-LRDIEGVQPGRRFKRLIR----DRGYSSFESEVYRLDGSTLWIAETAHAV
HGADGELLYYQGTVEDISDRKRYREQLEHQANHDPLTGLPNRNLLRDRVEQARVHVAREGGEVAVAFVDLDNFKVINDSLGHAVGDELLMVVAARLKSCL
RAIDTVARYGGDEFVLIVHYPGDATIGRVLDRVLQAIARPIQVAGHELMVTCSIGVAMLEGDAG-VDVLLQHADAAMYSAKAAGRSTYAVYTPDLNAAAV
ERLRLESALRHALERGEIDVHFQPKVD-RAGRVCSLEALARWTSAEFGAISPAVFVPIAEDTGLIGPITEFVLRSACEHAARWIGTGVAPLTIAVNLSPR
LFRADGLVSRVSGELAAAGLPAACLELEITEGTLMGEGIDAVQQLRALKAIGVRIAVDDFGTGYSSLAYLTRFPLDILKVDKSFVARAVPGSEEAILARA
IVSLGLELGLTVVAEGVETQEQWQLLSDAGCHEFQGYLFSRPLPVQLADAWLAS------
>tr|A4G434|A4G434_HERAR Chromosome, complete sequence OS=Herminiimonas arsenicoxydans GN=HEAR1092 PE=4 SV=1
------------------------------------------------------------------------LANLEGMVYRCRL------DQQWTM-EF
V-------GCLALTGYTEEDILNSRVSYD-DITHPDDREYVRTAVMQAVTGNRRFDVEYRIVRADGEVRWVWERGTNAMHDNK----LEGFIQDITERKQ
ADEALREAESIFENAIEGIYQSTPSNGYLAVNPALARMYGYDTPQDISM-LRDIEHVDPQRRFMRQMA----ENGITNFESRIYKSNGDIIWISENARAV
HTSTGELLFFEGTVEAITERKLHEAEIQFQATHDALTGLPNRTLLYDRMQQAVLHSARYGNLTAIAFLDLDQFKFINDSLGHQVGDELLKITAQRLTSCL
RESDTVARQGGDEFVLLLTSQPSESITHTMQRVLHEVAQPWMANGLEFRITCSVGVTLCPDDGRDAETLLKNADSAMYKAKELGRNNFQYFATEMNDTAT
DRLALLNRLRQAIPNHEFVLHYQPKINLANGDIIGAEALIRWNSA-EGMVSPGSFIPLAEETGLIIPIGVWVLETACRQNRAWQLAGYAPITISVNLSSR
QLARGDIVEQVEQVLAETGLEAQYLELEITESVMASDVEKSFALLTRLRLLGVKISLDDFGTGYSSLSYLKRFPVDTLKIDQSFVRDLATSQDSAAIVKA
IISLGHNLNLTVLAEGIETEEQFQFLLKSACNEGQGYLMSRPVSHQHFELLLQR------
>tr|A6T0F0|A6T0F0_JANMA Sensory box/GGDEF family protein OS=Janthinobacterium sp. (strain Marseille) GN=mma_2307 PE=4 SV=1
------------------------------------------------------------------------LANLEGMVYRCRL------DAHWTM-EF
V-------GCFALTGYTEEDLLNSRVSYD-QITHPDDRRHVRDTILEAVRNNRRFDIEYRIVRADGSIRHVWERGTNISHDNK----LEGFIQDVTERKQ
ADEALREAESIFENAIEGIYQSTPSDGYLAVNPALARMYGYDSPQAIST-LRDIDNVDPQRRFKRLMA----KHGVTNFESRVHRRNGEVIWISENARSV
YNSDGTLLFFEGTVEAITERKLHEAEIQFQATHDALTGLPNRTLLYDRMQQAVLHSERYGKLTAIAFLDLDQFKFINDSLGHQVGDELLKITAQRLTSCL
RESDTVARQGGDEFVLLLTDQPNEAITHTMQRVLHEVSQPWKANDLEFQITCSIGLTLCPDDGRDAETLLKNADSAMYKAKELGRNNFQYFSAEMNSSVT
DRLELLNRLRQAITNEDFVLHYQPKVSLASHQIIGAEALVRWNSAHSGMVSPASFIPLAEETGLIIPLGEWVLRTACRQNRAWQDAGYPPIPISVNLSPR
QLARGDIVEVVERILTETGLEAQHLELEITESVMTTDVEKSFALLTQLRSLGVKISLDDFGTGYSSLSYLKRFPVDTLKIDQSFVRDIATDQDSAAIVKA
IISLGRNLNLTVLAEGIETEDQFQFLLANGCDEGQGYLMSKPVPNKNFVDLLTQ------
>tr|J3DJX6|J3DJX6_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Herbaspirillum sp. CF444 GN=PMI16_00544 PE=4 SV=1
------------------------------------------------------------------------LANLDGMVYRCRD------DQEWTM-EF
V-------GCLELTGYQPQDLLNHRVSYD-SITHPEDRDAVRKTIQTCLLAKKRFEMEYRIIRADGEVRWVWERGVGIYTAAG----LEGYVQDVTARKE
ADQALLEAESIFENAIEGVFQSTPDGSYIAVNPALARIYGYKSPEDIVS-LRDIKHVEPERRFMKMME----QFNSSNFESRVYRRDGEIIWISENARAV
HDDAGTLMFYEGTVEAITERKLYEAEIRHQATHDALTGLPNRTMLHNHLQRAVQNSRQKGSLTAVVFVDLDQFKFINDSLGHQVGDELLKTVAQRLVSCV
RETDMVARQGGDEFVLVLQNQPDSNITEVLQRILTAVARPWVVGDREFHITCSIGVSRCPTDGRDVETLLKNADSAMYKAKELGRNNFQYFAGWMDAQVS
NRLEMLVSLRRALDRDEFKLHYQPKISLASGRIIGAEALIRWVTPDQGMVSPDRFIPFAEEAGLIVPIGEWVLRTACAQNKIWQDAGLAPIPVAVNLSPR
QLDQ-NLPEFVRQVLLESGLAAAWLELEITENVVMRDAEKTVATLNALKRLGLQVSVDDFGTGYSSLSYLRRFPVDALKIDKSFVRDIARDADSAAIVKA
VISLGHILNLRVIAEGVEDQEQYDFLLENGCDEVQGYLLGKPMPVEDFTRRLEL------
>tr|C6XEG9|C6XEG9_METGS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylovorus glucosetrophus (strain SIP3-4) GN=Msip34_1699 PE=4
------------------------------------------------------------------------LKNMEGMAYCCLV------DAHWTM-LF
I-------GCFDLTGYRPDELLNGCTSFE-ELTLPEDRARIRNTVDDALSRRERFEIEYRIMTIDGQIRWVNERGTGIFNPQG----LEGFIQDITQRKL
NEQALQEAENIFENSIEGIFQTSQDGQYINANPALARIYGYESPEEIQS-LNNIAQVQPESRFLTLMQ----LEDRVNFESQIYRRDGSTIWISENARAV
RNDAGKLLYFEGTVEDITERKSYNALIEYQATHDDLTGLPNRTLMQDRLLQAISYADRTASKLAVVFVDLDKFKDINDSMGHFIGDQLLIAMARRLESCI
RDSDTVARPGGDEFVLLLSNIHGDALSQTLQRVLALTSEPCSIEGKDFTVTSSIGISLYPDDGKTSETLLKNADTAMYKAKQEGKNNFQFYTRELNSILV
ERLEMEYQMRNALGHNEFHLHYQPKLNLRTQRITGVEALIRWHNPRQGLISPNRFIPIAEESSLIEQIGSWVLEKACMESIALSQLSGYDVPVSVNVSPR
QFQQSNLVGNISRVLQETGLKPSLLELEITEGTLADTSPQFIKVLNDLKGLGIKLAIDDFGTGYSSLGYLKHFPIDNLKIDRSFVMGLESDTANQAILKA
IVALGHNLGINLVAEGVETERQRDFLLSIGCDEMQGFLFSQPLPFDQAGKLLLA------
>tr|I3CQP9|I3CQP9_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor domains protein OS=Herbaspirillum sp. GW103 GN=GWL_29700 PE=4 SV=1
------------------------------------------------------------------------LANLDGMVYRCRD------DAHWTL-EF
V-------GCYALTGYTPEDLLNSRISFL-QLTHPEDRAMVRSHIDLCMRERRRIDIEYRIVHADGSLRWVWERGVGLYNAAG----MEGFLQDVTERKE
AAQALQEAESIFENAIEGVFQTTPDGTYIAVNPALARIYGYHSPEDIVG-LRDIRHVEPERRFMRLME----QQGSSNFESRVYRRDGDIIWISENARAV
YDDGGTLVCYEGTVEAITERKLYEAEMRHHATHDALTGLPNRNMLHEHLQRAIQAARQKGGLTAVVFVDLDQFKFINDSLGHQVGDELLKTVAQRLQACL
RDTDMVARQGGDEFVLVLQNQTGLGIAEVMQRILAAVARPWQAGDREFQVTASIGVSRYPIDGKDVETLLKQADSAMYRAKEQGRNNFQFFAPWMDTQVS
NRLEMLINLRRALDQDEFKLYYQPKLSLKDGSVIGAEALIRWQSPEQGMVPPDRFIPFAEEAGLILPIGEWVLRSACHQNKRWQEAGLPTIPVAVNLSPR
QLNQ-SLPEFVAGVLEQSGLAASCLELEITENVVMKDAEKSVATLHALKRLGLQISVDDFGTGYSSLSYLRRFPVDALKIDKSFVRDIARDADSAAIVKA
VISLAHILNLRVIAEGVEDEEQYAFLKENACDEVQGYLFGKPMTVEDFTAWLTR------
>tr|D8IQH6|D8IQH6_HERSS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor domains protein OS=Herbaspirillum seropedicae (strain SmR1) GN=Hsero_
------------------------------------------------------------------------LVNLDGVVYRCRD------DAQWTM-EF
V-------GCLALTGYLPEDLLNQRLSFL-ELTHPEDRTLVRNHVDACMRERRRIDIEYRIVRADGAVRWVWERGVGIYNANG----IEGFLQDVTERKE
AAQALQEAESIFENAIEGVFQTTPDGTYIAVNPALARIYGYHSPEDIVG-LRDISHVEPERRFMRLME----EQGSSNFESRVYRRDGEIIWISENARAV
YDEAGKLSCYEGTVEAITERKAHEAEMRHQATHDALTGLPNRNMLHEHLQRALRVARQKGALTAVAFVDLDQFKFINDSLGHQVGDELLKTVAQRLQACL
READMVARQGGDEFVLVLQNQTGAGIAEVMQRILAAVARPWQAGDREFQVTASIGVSRYPADGKDVESLLKHADSAMYRAKEQGRNNFQFFAPWMDSQVS
NRLEMLINLRRALDQDEFKLYYQPKLSLQDGRLIGAEALIRWESPQQGMVPPDRFIPFAEEAGLIVPIGEWVLRTACRQNQAWQQAGLPPIPVAVNLSPR
QLNQ-SLPDFVAGVLAQSGLAASWLELEITENVVMKDAEKSVATLHALKRLGLQISVDDFGTGYSSLSYLRRFPVDALKIDKSFVRDIVRDADSAAIVKA
IISLAHILNLRVIAEGVEDEEQHAFLKENACDEVQGYYFGKPMEVAVFTAWMSE------
>tr|Q47C60|Q47C60_DECAR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (strain RCB) GN=Daro_2841 PE=4 SV=1
------------------------------------------------------------------------FSKLDGMLFRCLL------DEYWTL-LS
V-------GCHELTGFRADDLVKQQNSLE-SLAHPEDRAAVRGTILAALETGSRYSIEYRIVCRDGEEKWVQERGVGLRDEAG----LEGYLEDITDRVQ
AQIQLTETESIFENSVVGMFQSTESGRYLAANPALARLYGYSTPEAISS-LADIASVDPQRRFKQLIQ----RDGRTNFESEITCRDGSRIWIAEHAHAV
RSADGSFLYYEGTVEDITERHRYQSVLQHQATHDPLTGLPNRNLLEDRLAQAVQLARRKSSKVALAFVDLDNFKVINDSLGHAAGDQLLIEISSRLRAAL
RGLDTVARYGGDEFVLILGEQTSADTMHLLERVLVSIQAPLALEGHGLRINCSIGVSVFPDDAQDLDGLLRVADVAMYHAKESGKGQYCFYTRDLNQAAQ
DRFSLETALGSAIENNELTVVYQPKVD-GEGMVRGFEALVRWNSAGRGLVTPDRFIPLAEETGQILAIGEQVLYAACRTAANWPLIDGQALSVAVNLSAR
QLREPGLPGLVADALAVSGLPPECLELEVTESMIMGDMEHNIRVLKSIKALGVRIAVDDFGTGYSSLAYLQRLPIDTLKIDRSFVSGCNRGGKAMAIPHA
IIFLGKTLDLHIVAEGVETDEERAILAVCGCNEFQGYLFSRPLQSAAVDTYLQA------
>tr|D5CTK4|D5CTK4_SIDLE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sideroxydans lithotrophicus (strain ES-1) GN=Slit_0068 PE=4 SV=
------------------------------------------------------------------------LNNLDGMVYCCLY------DADWTM-VF
V-------GCKQLTGYDAQAFV-SEICLE-AITIPEDREPVNKAIGDAISNGKRFAVEYRIIHADGRTRWVSERGCPLYDDNG----IEGFMQDVTQRKL
SEVAARDAESIFENALEGIYQTTPDGHYLNFNPALARIYGYESAVDVCS-ISDIQQVDPDKRFITLMN----VHGQSNFEAQVYRKGGEIIWISENAHEV
KDRDGKLLFYEGTVEDITERKNYEQQIEYQATHDALTGLPNRTLLADRLQQYIGIADRYTSKLAVAFVDLDQFKLINDSMGHHAGDELLKIMAARLASCV
RESDTVVRLGGDEFVLLLTGLHKEDISESMQRVLSSVAGPCTIEDRDFVVSCSIGISIYPDDARDTTTLLKYADSAMYKSKQSGRNNFQFYTDELNQRLM
ERLDLEYRLRLALENEEFLLHYQPKLALVSGAICGAEALIRWQPAGESMISPASFIPIAEETGLIEDIGLWVLHEACRQAVKLNRLYGRELPIAVNVSPR
QFRQSDLVSMVRSALLNSGLNPACLELEITESSLVHDTGSFIKTLQELKNLGVGLAIDDFGTGYSSMAYLKDFPVDRLKIDQVFVSNLEAEPSNIAILKA
IVALGHSLNMKVIAEGVETAYQKAFLLGIGCDEMQGYHFSKPLHMDTFGKLLSD------
>tr|J3HYX1|J3HYX1_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Herbaspirillum sp. YR522 GN=PMI40_00334 PE=4 SV=1
------------------------------------------------------------------------LANLDGMVYRCRA------DAQRTM-EF
V-------GCLPLTGHLPEALLNQQLSFE-QLIHEDDRELVRWHIGECLRQRRRFDVECRIVCADGSVRWVWDRGVAIYNATG----VEGFMQDVTERKE
AAQALQEAESIFENAIEGVFQTTPDGTYIAVNPALARIYGYRSPEDIVS-LRDIRHVESERRFMRLME----QHGSSNFESRVYRRDGDIIWISENARAV
HDDAGTLMFYEGTVEAITERKLYEAEIRHQATHDALTGLPNRNMLHDHLQRAIQ-ARQKGSMTVVAFVDLDQFKYINDSLGHQVGDELLKTVAQRLLSCL
RDTDMVARQGGDEFVLVLQNQSGAGIAEVMQRILAAVARPWPVGEREFHITSSIGVSRYPEDGKDVETLLKKADSAMYKAKEQGRNNFQFFAPWMDTQVS
NRLDMLISLRRALDQEEFRLFYQPKLSLSNGRIIGAEALIRWQSPEQSMVAPDRFIPFAEEAGLIVPIGEWVLRTACRQNRAWQDAGLLAIPVAVNISPR
QMNQ-SLIDFVANVLRDSGLAASWLELEITENVVMKDAEKTVATLHALKSLGLKISVDDFGTGYSSLSYLRRFPVDALKIDKSFVRDIARDADSAAIVKA
VISLAHILNLRVIAEGVEDEQQHDFLRENGCDEVQGYYFGKPMSVEDFTLRLRD------
>tr|D7DIU0|D7DIU0_METV0 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylotenera versatilis (strain 301) GN=M301_1595 PE=4 SV=1
------------------------------------------------------------------------VDNLEGLVYCNLY------DQHWTM-IY
V-------GCKDLTGYFPDDLINNLVSYE-EIIFKDDRALVRYAIDEAVKQGKRFEVEYRIRHANTDIIWVCERGNPIYNAKG----IEGFIQNITQRKA
AEQSLHDAESIFENAIEGIFQTSPNGHYLIVNPALAKIYGYSSPEEISV-LNNIQQVTPGRRFVQAML----ANQSHNFESLVYKKDNSTIWISENARMV
HDKAGNLLYYEGTVEDITARKNYDHKIEHQAKHDSLTGLPNRYMLNDRLQQSINFADRYKNKMAVAFVDLDQFKLINDSMGHEVGDQLLLIMSKRLSSCI
REVDTVVRLGGDEFVILLTNIENNDVLISMQRVLTAVAAPCVINELDYVVTSSIGISIYPDDGIEPNTLLKNADTAMYKAKKAGRNNYQIYTQELNEALT
ERVTMEYRLRLAIENGELLLHYQPKVDFATGLISGAEALIRWQTPEGELIPPVKFIHIAEETGLIESIGEWVLIEACKKAKELKEKMGRPIPIAVNVSPR
QFKQPNLAQTIKNTLELTNLDPDCLELEITESTLIDDAAKFIQTLHALKTIGIKLAIDDFGTGYSSLAYLKDFPIDRLKIDKAFVSNLENDPANTAILKA
IIVLGQSLGMKVIAEGVETRFQHDYLQSIGCDELQGYYFSKPIPAIEFEALLQN------
>tr|Y0KDK1|Y0KDK1_9PROT PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Methylophilaceae bacterium 11 GN=Meth11DRAFT_0023 PE=
------------------------------------------------------------------------VDNLKGMVYCNIY------DEHWTM-LY
I-------GCEGLTGYSPDQLINQNISYE-EVIAPEYRSYVRVEIAKAVETNTSFEIEYPIHHANGSVIWVSERGYPVYDDHG----LEGYIQDISDRKN
VEASLKKAESIFENAIEGIFQSTLDGQYLVANPALAAIYGYESSAAISA-LNNIQHVLPTRRFVKEIT----TKGKHNFQSQIYRKDKSIIWISENARLV
YDKDNQPIYYEGTVEDITELKNHAVEIEYQATHDNLTGLPNRYILNDRLQQSINFASRYNTKLAIVFVDLDQFKLINDSMGHSVGDQLLVSVSKRISNNV
RDIDTVVRLGGDEFVILIPNVQTQDIELSLGRLLNHMSAPLNINDFNFSITCSMGISVYPDDGKDPDTLLKNADSAMFKAKHTGRNNFQFFTPELNEKLT
DRFNLEYKLRRAIEHKEFVLHYQPKFNLSTGQISGAEALIRWQPSDYETIYPLTFIQVAEETGLIVKIGQWVLNTACKKAKQLQQVTGKAIPIAINVSPK
QFRQPNFVEIVQDALILSDLKPELLELEITENIMIEDTPKFIETLQQLKAIGVKLSLDDFGTGYSSLSYLKDFPIDQLKVDRAFVHAIEEDANNMAILKA
IIILGQSLGLRVVAEGVETEFQFDFVKSVGCDEVQGYYFSKPLPEAHFDRLIEE------
>tr|A0A0B1TTM8|A0A0B1TTM8_9DELT Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Desulfovibrio sp. TomC GN=NY78_4048 PE=4 
------------------------------------------------------------------------PEDVHQRIFQCSPNAALLRDADGIV-LA
V-------AFEALFGVDAAEVVR------------DLRAVVRPAVDRDSLSGAAFLRETRWGAHDGGTVDVSLSQFPVGDSGG----SCVIFRDISGRRR
AEEQLDAAESIFENAVEGIFQTTPGGRYLEANRTLARIYGFVSVAETEY-FRDIKNVDPRRRFVRRLS----AHDEHNFESQIRKKDGAVIWISENARVV
RDASGEAVYYEGTVVDITERKAFEEQITHQAFHDALTGLPNRSLFADRLDRALTRGKRRSYQYAVLMIDLNKFKGINDTLGHQAGDQLLIEVSRRLLSCV
RTMDTVARLGGDEFAIILEELKSKEVMTVVERIGTVLGRPCVLCGSTVTPGASIGIVLRTLDYTSAEDILRDADIAMYRAKESGRTSM-IFDRQMHQEIL
EAITLEADLRAALERGELLLHYQPIVDVQSGRIEGFEALVRWDHPIRGLVPPVRFIPLAEETGLILPLGRFVITEACRQLRSWQLTMPGALSVSVNVSCR
QFVKDGLVEHVSGVLAETGLDPACLKLEITESVLMHDAQHTAGELNRLKKLGVKIAIDDFGTGYSSLSYLRQLPIDHLKIDRSFISGDDCNGESQEIVKS
IIALARSLGLTVIAEGVEHQDQLDKLRFADCDKAQGFMFSRPVDKDAALQLLRE------
>tr|G7QAB8|G7QAB8_9DELT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio sp. FW1012B GN=DFW101_2264 PE=4 SV=1
------------------------------------------------------------------------PDDAFRRVFLCSPNAALLRDADGTV-LA
A-------AFEALFGVEIPEVVL------------DLREVLRPVSSRPSLRGAAFLRETRWAAGEGDAADVRVSQFPVGMLGD----TCMLFRDIASRLL
AEDRLRDAESIFENAVEGIFQTTPAGRYLEVNRTLARIYGFESVAEREF-FRDIRNVDPRRRFVRELA----AHDQRDFESEIRKKDGTVIWISENARVV
RGADGLPAYYEGTVVDITERKAFEEQITHQAFHDALTGLPNRSLFADRLERALTRARRRGSQYAVLMIDLNKFKGVNDTLGHQAGDQLLVEVARRLSGCV
RSMDTVARLGGDEFAVILEEFKTKEVMTVVERIGVGLGKPFVLCGKTVTPEASIGIVLHTRDYAAADDLLRDADIAMYRAKEQGRASM-IFDRKMHQEIL
EAISLETDLRQALEAGELLLHYQPIVDVKDSRIVGFEALVRWDHPDRGLVPPGQFIPLAEETGLILPLGRFVIDEACRQLRAWQLEMPADLSVSVNVSCR
QFVKDGLVEHVAQVLAATGLPPACLKLEITESVLMHDAEHTARELNRLKALGVKIAIDDFGTGYSSLSYLRQLPIDHLKIDRSFISGQGCDGESQEIVKS
IISLARSLGLTVIAEGVECPDQLDRLRLADCDKAQGFMFSRPVEATAAGRLIRQ------
>tr|Q1K234|Q1K234_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_2700 PE=4 SV=1
------------------------------------------------------------------------VVDREGNVVDCNF------AAHGLLQEF
G-------AYNDIQGYAEIQGW--WSDNG-QPVHPDEWGISRSL----SRGETCLREKIDIACTDGVRRTVLYTSLPLKSENG----AMALVQDITEKRK
TDEV----LFSIEQASEAIFWINDEGRFLFVNDQACHSLGYSASELSLH-LWDIDPAE-RWAWERMK------SDPQVFETRHQRKDGRIFPVEVSASQC
------------------IRKKYEKELEHQSNHDALTGLANRVLLDDRIQQAIVHAERAQRNTAVFLLDLDRFKVINDSLGHSQGDAVLLAVAERLSACI
SPGDTLSRLGGDEFAIVMTHVNHADARIMAQKILNAFEQPFPLGNRELRITTSIGASLYPRDGEQSEDLLRHADAAMYQAKKQGGNGFQFCSEEMDTRAH
KALELEGDLRQALQLGSFVLHYQPKVKIASGKIDGCEALVRWNHPDKGMISPDDFIPLAEETGLIIALGEWVLREACRQFKAWQAQGLPPIKIAVNLSAR
QFLQSDFVESIQTILHEFDIDPHWLDLELTESMVMEDPDRIAKLLAELKQIGFALSLDDFGTGYSSLNYLRRFPIDCLKIDRSFILDVASDATAASVANS
VIGIAHSLGIHAIAEGVETREQYAFLAMCECDSIQGYLFSKPLPANDLAALLAN------
>tr|H2CFC2|H2CFC2_9LEPT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptonema illini DSM 21528 GN=Lepil_2069 PE=4 SV=1
------------------------------------------------------------------------L------------KRGQVTIASWIL-VF
NLAISLTSGGVKSPGFAAFFII---IFFA-GL----------------LLGGRVAALIAFLSSLSGLFMWLIERWGPVYRHGDLF--SDRFMRRTVDRLR
SVSVRRLAESVIAALDEGIVVQDRQGIITAHNRRAEEILGMTDDEMGRKSWRAIREPFPGEEAMVTLR----TGAPHNVIMGVHHRDGSQHWISINSQPL
FKGEEEL-----------ERRAVDAMIRRQAFYDSLTELPNRILFLDRLNQAIAHCRRSGTVLAVLFLDLDRFKNINDTLGHGVGDGLLSAVADRLREIL
RSDDTVSRSGGDEFLVLLSDLSQTDAGFVADKILTAMAMPFRVGDYELHLTTSIGISVYPDHGEDAESLIKNADIALYRAKEMGRNTKASFSMAMDR--H
ESMHTENELRRSLKEEHFELHFQPRVELLTGRITGFEALLRWNHPEKAMIGPDRFIPIAEESGLILPLGEWVIREAERVTRKWRGLGLDNFTISVNVSGR
QFFQPGFVHKLLSIV---SENRSCIELEITETIAMKTGEQTLDILRQLDRAGFSLALDDFGTGYSSLRYLQEYPIDTLKIDRSFVEKLEQDERNRHIVET
IIGLGRHLGLRTVAEGVQTPEQRERLASMGCDEIQGFLFSPAVPEAAALAMMQS------
>tr|A0A0C2BTY1|A0A0C2BTY1_9BURK Uncharacterized protein OS=Herbaspirillum sp. TSA66 GN=TSA66_04340 PE=4 SV=1
------------------------------------------------------------------------MLERSRRRKDLELCLSGAEQGLWEWQIN
AETVKFNANWAIPLGYARGEMSPCVLTWQ-HIVHPDDWPTLFAADAYFSGKSRLFDPEIRMRHS-DAFVWMQLHGKAVVDEQ-RPLRLMGTYMNIGRRKH
AEIELRKRETMIASLQDAVLVLDQAGRITMRHVPENSALSFLTPALLGQLYAAALPGAIAQL-LDQAIADIRASRQVQV-ECELAADDCRHYLHLTVNAL
AGSDQDPTGYLVVMQDITPRKMAEEEIRTLAFFDALTKLPNKRMLRDRLRLALGMSGRNGRCGAVLFVDLDNFRRLEQTHGHAVPDHILMEIARRLERCM
QGSSVVACAGRDQFLVLLEDLSDEIVSRVGEKIQTAINQAVVIADQEYRVTASIGAAMINGQSHSEDMLLQQVQLAKDSAKSAGGNTLKFFDPEMQASAQ
NYVALEQAIYKGLQREEFFLVYQPQLDS-DGRIIGAEALVRWQHPEQGLLGPGHFIALAEETGLIVPLGLYVLKAACHQLCRWQLNAATAHTVSVNVSSR
QFEKPGFVDDVELLVQSSGINPRQLKFEITESLLLENTESIVGKMRRLREIGISLSLDDFGTGYASLAYLKNLPLDQLKIDQSFVRNAPQSSVDVAIIRS
IMSLGKSLGIAVIAEGVETEAQWRFLIGEGCTLFQGFHFSRPCGVREFEAQL--------
>tr|T2L4N1|T2L4N1_9GAMM Uncharacterized protein OS=Halomonas sp. A3H3 GN=HALA3H3_320007 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------MYYFASSAALPALGRWGLLLALLLKRRMQHNRAL
LQSNK----TILDSVDAFIYIKSPSLEYQYVNRRMSDLFGLPADKIIGKRDAAFFDAGSAAEINQVDRNVLDSGKKVTVEESNVLRGESRVRTFLSKMPL
SMSPGAPPSLCGISTELTDYLEMQSRTHYLAFYDSLTGLPNRRLLMDSLTATIDHDEWATFFSAVLVIDLDNFRLVNDIQGHESGDQLLVSVAEQLRQRL
DEEVTLARFSSDEFVVLIKNLGEQKAERVGRQLLEVIAQ---LRSHSLPISASIGISLFTGAGYSMDSVLQQADMALQQAKSAGGNTLRFFNSEMQTSVL
ERASLEADLHQALKRNELALHYQVQVDH-QGVTTGVEALLRWYHPQRGWVSPATFIPLAEENRLIVPIGYWVLRSACEQLAKWSHQPAYAPSISVNVSSV
QFQQPEFVRDVEELLAETLAPPNRLVLEVTESLLMHEPVRVRSTMLKLRARGIRFALDDFGTGYSSLSYLKRLPLDELKIDQSFIRELLTDKTDAAIVDT
TILLAVSLGLTVVAEGVEKKEQFDWLRGHGCYRYQGYLFGRPTPIEYLFESY--------
>tr|A0A014NHH8|A0A014NHH8_9BURK Diguanylate phosphodiesterase OS=Comamonas aquatica DA1877 GN=AX13_09155 PE=4 SV=1
------------------------------------------------------------------------SRERLQAERRLRLALDNARMGVVTLTEG
ADLVEIDGHFPPIADKALRGLRMGV--EFLQHLTADSQ----NKVHKLLEDGEDLHLLTRWRRMNGEEGWMEVHAGYVV----SEQAVVGVCRDVTREVE
REEALRQAAVVFESAADAILILDPEGRVTTANPAFTRLTGWPNADIRGRHPNEFLHARRGS-DREL--LNGTPIFLGHAEVVCLRHDGTSFPAWEHVAPV
RDDSGNVTHRVLTFTDISALRMAESRVRHLAYHDPLTGLGNRNQLREVLANLP--APGDEAEWVLMFIDLDGFKVINDSLGHEVGDSLLVVVADRIRGVL
RQGDQAIRLGGDEFVLLVHCAHDSDIEGLADRLLQVMQIPLDVPGSSVQVSASIGVAVFMRDGDTADSLLRSADIAMYAAKTAGRNRFERYHPRMAEVAN
ERLAIEQGLLQAMLNGELSLHWQPQVSLDGRRVVGAEALLRWTSVQLGQVGPDRFIPVAEESGIIRSLGTWVLRQSLATWAEWCRAGLVQGRLAINVSAL
QLQDDTFIDVLARELKEAGLQPQDLEIEVTETAL-QRVPQVEQRLTRIADLGIQIALDDFGTGYSSLSMLKLLPLNRLKVDRAFVHDVVTTPSDQAIVRA
IAAMADALGLELIAEGVEEEDQRQWLANLGFKEAQGWLFAKAMSGVDFMRWLAD------
>tr|F3KRS8|F3KRS8_9BURK Uncharacterized protein OS=Hylemonella gracilis ATCC 19624 GN=HGR_05631 PE=4 SV=1
------------------------------------------------------------------------ERKTRRAERRFRLAMEAGRFGVMEFDAA
RRQFELDGFMESILAQPSQSFTVGH--DFLRHIEESVR----QSIDSLLLAGRMVQVCTAWRRDDGERIWLEIHASYFP----EEDRVVGILRDVSERVQ
AEEHLRQAAVVFETTGDGILILDREQRVCMGNKAFERITGWRVQEVLGQRPDDFLHASRSG-DRRR--VVATDDDSIQVEITCRRRDNSLFPAWEGLSPV
IDRVGKLTHYVLTFCDISALRSVESRLTHVALHDALTGLGNRHQLDICLRHNIARARVDDGGFGLLFIDLDGFKNINDSLGHSVGDEMLVEIARRFRTTL
RQNDVAVRMGGDEFLILLDQLRTEDAMALCRKLLALISEPIRSVGQTVSTTASIGIALFPEHADSADELVKAADTAMYAAKAAGRNRGAVFSQGLARRAL
ERLQLEQGLRQAIVRGELELQWQPVIDLRDGRIIGAEALLRWNHGDSGRISPERFIPLAEETGLILPIGDWVLEQACRNAADWKAQGLEPGRLAINVSAL
QLQQEGYAERVGEALSRHGLSPEMLELELTESSL-QHGEAVQMALHKLRALGVYLALDDFGTGFSSLSMLKFLPLTRLKIDRSFIRDLATDPNDMAIART
IAVMAMTMGLEVTAEGVETEIQRTILLGLNVREVQGWLYHPALPVGKFTELLVA------
>tr|A0A0A5LGG5|A0A0A5LGG5_AERHY Diguanylate phosphodiesterase OS=Aeromonas hydrophila GN=MC69_03535 PE=4 SV=1
------------------------------------------------------------------------VTEQVEAQQRLQLAMSAGQIGVWEWHVT
EDRLQFDGQVERLLGTTASQFQGGM--EFIKRFDPL-G----EQFRAAVNGTAPIHLTLGYLGPDQLRGWVDIHADHVAATDHQGRRITGVIHDATSRCN
QEDKLRQANVVFETAAEGIIIMDGQRQIISVNPAFSSMTQYEEAEIVGKSPEAIMHPRRHT-DIDYPWHTLLPGHAWHGEMMCLRKDGGYFTSWQHVSAV
HDSRHNTTNYVIAFSDISAIRKAEAQLNHLAYHDPLTELGNRNLLQERLELELKTAQLNHQQLALLFIDLDGFKLINDTLGHRAGDELLKLLAERIRRVL
RHNDVAARLGGDEFLVLIPFFEPQELERLAEQLLACLREPVEGN-ERVAVSASIGIALYPEHATSPDTLVSAADSAMYEAKNRGRNGYLFYTPDMTEQTR
ERMSMEQGLFKAIEQHQLCVLYQPMTELASNRMSGLEALLRWQHPSEGMIGPTRFIPVAEECGLIEQIGEWVMRTACRQGQAWLAAGLAVPRLSINVSVR
EMRSAGYVERVAAILAETGFPPEKLEIEVTESII-QRVDQSLQLFRRLKALGVQIAIDDFGTGFSSLSLLKSLPIDRIKIDRTFVQALPDDKHSRELCRT
IINLADSLGMVVTAEGIETQAQRQFLQSLHCQEGQGYLFSHPLAEPHLAEQLGS------
>tr|A0A091A3T3|A0A091A3T3_AERSA Diguanylate phosphodiesterase OS=Aeromonas salmonicida GN=JM66_15990 PE=4 SV=1
------------------------------------------------------------------------VTEQVEAQQRLQLAMSAGQVGVWEWHVA
EDRLQFDGQVERLLGTQANQFQGGM--DFIKRFDPV-G----EQLRSALKGTAPLHLTLSYLGPDQVRGWVDLHADHVAATDSLGRRIMGVLHDATDRCI
QEDRLRQANVVFETTAEGIIIMDGQRQIISVNPAFCNMTQYEADEIVGKSPESIMHPRRHT-DIDYPWHTLLPGHAWHGEMMCLRKDGGYFTSWQHVSAV
YDSRHNTTHYVIAFSDISAIRKAEAQLNHLAYHDPLTELGNRNLLQDRLELELKTAQLNRQRLALLFIDLDGFKLINDNLGHRAGDQLLKLLAERIRLCL
RHNDVATRLGGDEFLVLIPYFEPEELERLAEQLLARLREPVEAH-EHVAVSASIGIALYPEHAQNPDALVSAADNAMYEAKSQGRNGYLFYTPGMAEQIR
ERMSMEQGLIKAIEQHQLCILYQPMTDLTSNRLSGLEALLRWQHPDEGMIAPARFIPVAEECGLIEQIGEWVMRTACQQGQTWLAAGLSVPRLSVNVSVR
EMRSLGYVERVAAILAETGFPPERLEIEVTESII-QRVDQSLLLFTRLKALGVQIAIDDFGTGFSSLSLLKSLPIDRIKIDRTFVQALPDDKHSRELCRT
IINLADSLNMAVTAEGIETQAQRQFLQSLHCQEGQGYLFSHPLTEPHLAAQLAP------
>tr|K1J991|K1J991_9GAMM Diguanylate cyclase (GGDEF) domain-containing protein OS=Aeromonas veronii AMC35 GN=HMPREF1170_01239 PE=4 SV=1
------------------------------------------------------------------------ITEQYETEQRLQLAMRAAQIGVWEWHVA
EDRLLFDGQIEPLLGIEANQFHGGL--QFVDCFEPE-G----SQLKAALQSHDPIHLTLSYLTALNERHWVDIHADHVPATESVGHRVMGVIHNATARRR
QEERLHQANVVFDTTAEGIIILDSEHHILSVNPAFTMLTQYNAEEVIGRTPDIIMHPRRYT-DLDYPWYHLRPGNAWHGEMVCLRKDGSYFSSWQQISAV
YDNFNNTTHYVIALSDISAIRKVEAELNHLAYHDPLTELGNRHLLQERLALELKTAQLNRKRLGLLFIDLDGFKLINDSLGHGVGDELLKRLAERIRGCL
QHNDLATRLGGDEFLVLIPYLEPDELATLANTLLTVLREPVEAH-ELVAISASIGIAIYPDHADSPETLVSAADSAMYEAKSQGRNGFQFYTPCMAARAR
ERMQIEQGLLKALELEQLCIFYQPMTNLANGHLSGLEALLRWQHPNEGMIAPTRFIPVAEECGLIEKIGEWVMRNACKQGQNWLAAGLPVPRLSVNVSVR
EMRSPGYVERVAAILAETGFPPERLEIEVTESII-QRVEQSLDLFTRLKNLGVQIAIDDFGTGFSSLSLLKTLPIDRIKIDRAFVQALPEDKNSRELCRT
IINLADSLDMEVTAEGIETKAQHAFLQSLNCGEGQGYLFSKPLHVEHMGDRLHQ------
>tr|K1IP99|K1IP99_9GAMM Diguanylate cyclase (GGDEF) domain-containing protein OS=Aeromonas veronii AMC34 GN=HMPREF1168_01655 PE=4 SV=1
------------------------------------------------------------------------ITEQYETEQRLQLAMRAAQIGVWEWYVA
EDRLLFNGEIEPLLGIPAHQFKGGL--QFIDCFEPE-G----QQLRTVLQGKEPIHLTLSFITPLNERHWVDIHADHVAATESIGHRVMGVIHNATARRR
QEERLHQANVVFDTTAEGIIILDNNHRIISVNPAFTMLTQYDAEEVIGQDPGIVIHPRRYT-DLDSPWHQLHPDNAWHGEMVCLRKDGSYFSSWQQISAV
YDNFNNTTHYVIALSDISAIRKVEAELNHLAYHDPLTELGNRHLLQERLTLELKTAQLNNKRLGLLFIDLDGFKLINDSLGHGVGDELLKRLAERIRNCL
QPNELATRLGGDEFLVLIPYLEPDELITLANTLLTALREPVESH-EQVAISASIGIAIYPDHATTPETLISAADNAMYEAKSQGRNGFQFYTPYMAEQAR
ERMQIEQGLLKALELEQLCILYQPMTHLAGGHLSGLEALLRWKHPNEGLINPARFIPVAEECGLIEKIGEWVMRNACAQGRNWLAAGLPVPRLSVNVSVR
EMRSPGYVEQVATILAETGFPPERLEIEVTESII-QRVDQSLDLFTRLKNLGVQIAIDDFGTGFSSLSLLKTLPIDRIKIDRAFVQALPEDKNSRELCRT
IISLADSLEMEVTAEGIETRAQYTFLQSLNCGEGQGYLFSKPLHVEQMHERLHC------
>tr|N9VNS4|N9VNS4_9GAMM GGDEF/EAL domain-containing protein OS=Aeromonas diversa 2478-85 GN=G114_04591 PE=4 SV=1
------------------------------------------------------------------------ELGLQESEARLRLAIKAADLGLWEWNRN
QDKLHLSGNDALTLSFEN-GECDGI--EFIERFLIP-Q----NKLRQAIANGGAFNLTLGYVIPNGDLTWIDFYADFRNQEEGPSSQMIGVFLNVTERCR
REEQLPQANVVFDTAAEGIIIMDEHHRIISTNPAFTRLTGYRQEEVLGQTPDHLMHQRRQG-DSVTPWSHLGKQPAWHGEMLFVRKDGTHFTSWQHVSIV
HGSGNTASHYVIAFSDISAIRQAEAQLNHLAYHDPLTGLGNRNQLQDRLTIELQTAHLHQHRLGLLFIDLDGFKLINDTLGHSAGDQLLRLLADRLRSAI
RSNDLLTRQGGDEFLILVPQVQPQELLTLAEKVLQTIRPPIPSP-EPVSISASIGIALFPDDASTPEALLQAADSAMYEAKSQGRNRSLLYSPDMAQRSM
NKLRLEQGLAQALDRSELELHYQPIHSLQQSQPPGVEALLRWRHPERGIIAPDQFIPIAEESGLIEPIGQWVMREACEQGARWLDQGLPLSRLAVNVSVR
ELRAHDYAAQVAAILKQTGFPPHLLELEVTESIM-QQVDQSLRKFAELKQLGVTIAIDDFGTGFSSLSLLKSLPIDRIKIDRSFVQPIPHDRHSCELCRT
IITLAHNLDLTVTAEGIETPEQLTFLQSLGCENGQGYLFNPPMETTQFLSYWSQ------
>tr|F5RCC6|F5RCC6_METUF Uncharacterized protein OS=Methyloversatilis universalis (strain ATCC BAA-1314 / JCM 13912 / FAM5) GN=METUNv1_01930 PE=4 SV=1
------------------------------------------------------------------------EVSVERNEQLFKQALDAASLGVLEWRGD
SMELHGEGHLTGLFGERPVPLDESW--DFQSRVDEAVA----DTLNAALAHGDPVRIEFRTVGNGGARRL-EAHARA-YGGPSGERRIVGILQDVTQRRR
DEDRLRQSSVVFHTTAEAIVITDAQRRISAINAACTRITGHRETEVLGLDPDAVLGTG-HN-DAFYASLAAPSGGYWQGEVQCRRASGEYFPAWQSISAV
RGEDGRVTHFVAAFSDFTAIHRAEEKLNHLAHHDALTDLPNRLLFDDRFERAIEQARRAQQRCTLLFLDLDSFKVVNDTLGHAIGDDLLRGVAQRLRASL
RRSDTLARLGGDEFVVLTG-GTPEDASHLAIKILSALREPFDGD-EQIRISASIGIAVFPDHGSDRNVLMRAADIAMYSAKSQGRNRYQFFTEDMSERTH
ERMQMEQGLRRAIESDALEVHYQPQLRLSDRQRVGVEALVRWPHPDLGMVAPARFIPVAEESGIIEALGLWVLRRACRDIVGLPDCDGRQMRLAVNVSVR
QFLRDDFVTQVLEVLTETGFPAEALELEITESTV-QVIERSAGILDALKRLGVSISIDDFGTGYSSLSVLRGLPIDRIKIDRSFVLDLTENDDARAMIDA
MLALGRSLRMKTIAEGIELAEQADLLTRLGCDEGQGYLFARPMPLADLRLSLTR------
>tr|M5DSJ0|M5DSJ0_9GAMM Uncharacterized protein OS=Thalassolituus oleivorans MIL-1 GN=TOL_1987 PE=4 SV=1
------------------------------------------------------------------------DIEIRLSEQRLRLALDAAHMSVWEWQSP
STLNTTN-TAQLVAVDPPGVISQPL--DLLEHIHPEVQ----QDVENSAHFSRIIRMRK---SQQSEYRRVELFANL-FLWSDNNCRVVGVAQDVDDRYK
ADEKLRQASAVFNCTSEGIVITDGGRKIISVNPAFEEITGYELSEVKGLDPDDFLHARRHS-DQFYPRLH-DEGNFWSGEIGCSTKSGHRFPAWEHVCSV
YDEVGHLTNYVFTFSDISELRRAEKNLARMAYLDALTGLGNRVHMERVLEDAMERRDDSRSSVAVLYMDLDGFKVVNDTLGHSEGDRLLQILAQRFQDSV
REGDIVTRIGGDEFVIVVQDIEEVGLRKMAQKLLRAVQAPIENR-ETVEVSVSIGVAISKPSIKDFDELLRAADTALFEAKHQGKNRICFYDFVLAMESG
ERLRIERHLKQALNNHELTVEYQPLIDIDNQRVRGAEALCRWYHPELGMIPPDRFIPIAEQSDMIINIGAWVLQESCRAIRGWLDAGIKDVSVAVNVSVR
QLCDTSFCNIVAAALKKYDLDVSSLELEITESAL-QSNDRVRNQLDQLRTLGVRLAIDDFGTGYSSLSRLKHLPIDRVKIDRSFVKDLPNDESDIEICRA
ILALCKVLDMQVTAEGVENEAQLNMLRDMGCGCIQGYYFSRSLVYERFIEWAKA------
>tr|A1K3A1|A1K3A1_AZOSB Uncharacterized protein OS=Azoarcus sp. (strain BH72) GN=azo0689 PE=4 SV=1
-------------------------------------------------------------------------------QENLERAQAVARTGSWYVDFV
SGQMDWSAET-----------------CLFGQAPG-YELFVHPEDQALWRQAVARG-LTHRVIVGGEVRWVHERA--ERRADGAALAGIGTVQDITDR-K
--QSLRQAATVFENTGEGVIIADAKNRIIAVNRAFTVITGYGPEEVIGRSPNLLRSGRHDAAYYDAMWRGVHEAGHWQGEIWNRRKNGEIFPELLTLSVV
RDHNGKVSHYVGVFSDISRMKETEARLQRLAHYDALTDLPNRVLLNLRLAHGVERVQRSGEMLAVLFLDIDRFKNVNDSLGHPVGDELLIEIARRLRSRI
RAEDTLARLGGDEFVILLDRIRANDVADFAQEIIDLLNQSFQASGQEVFVGASIGISLYPLDTDDATQLISNADAALYQAKEAGRNVYRFYTADLTRAAH
ERLGLEAALRRGLERGEFVLHFQPVVALDKGEVVGAEALVRWNHPTEGMIAPLRFIPLAEETGLIVPLGEWVLESACRQGREWLDCGR-PLTIAVNLSTR
QFRAGDLTATVRDILDRTGFPAALLELEITESTVMEDADRAVATLAALKGLGVRLSIDDFGTGYSSLAYLKRFAVDALKIDRSFVRDIADDENDRMIVAT
VVAMAHQMRLGVIAEGVETAEQLAFLRSLGCEAYQGYLVGRPQAAADFLGAVER------
>tr|B6BNY2|B6BNY2_SULGG Sensory box protein OS=Sulfurimonas gotlandica (strain DSM 19862 / JCM 16533 / GD1) GN=SMGD1_0410 PE=4 SV=1
------------------------------------------------------------------------------LHERIELALLGSNDGLWDWNIT
DDSIYFSPRWKEMLGFKDD-------------LPN-WQDRLQSALDEI-INGET-D-IHRIRHKNGDWIWTLDRG--KLDEGKAVRMI-GTHRDITNIQE
MQLKYSQQVQIIEQIHDSVISTDLNGYITSWNKGSQILLEYTEEEMLTKHVSSLFLEEDH--ALQEGTQELIKHGEYHADKRLVKKSGDIIFVSLSLSIL
KDEKGNPTALVGYCQDITKRKEAEEKLHYQAHHDELTQLPNRTFFNERLEQAIEKAKRNKTLIALFYIDLDHFKQINDSLGHEVGDIVLKITAERLKNKI
RKEDTLSRLGGDEFTLIIEELNAKDVSLLAQKIIEDLEKPIYIDTHTLYISSSIGISIYPDDDTDAKNLLKYADSAMYKAKEEGRNNFQFYSSEMTELAF
EHVAMEASLRQALQNEEFVVYYQPQMDGRTDRLVGMEALVRWNHPTLGLVQPYKFIPIAEKNGLIVQIDQWVMKSAMTQFVAWYKDGLNPGVLAMNLAVK
QLQKKDFIDTMSNLLKSTQCKPEWIELEVTESQIMTNPQEAIKILKQISEMGIELAVDDFGTGYSSLSYLKRLPIDKLKIDRTFIQDLPDDEEDVGITKS
VIALSKSLNLKVIAEGVETDEQKNFLVENGCQNIQGYLYSKPITANEMKERFLK------
>tr|A0A077LIR2|A0A077LIR2_9PSED Sensory box protein OS=Pseudomonas sp. StFLB209 GN=PSCI_3808 PE=4 SV=1
------------------------------------------------------------------------------TREQLQLALEAAQLGLWEWHIP
SGQLQADQRAAQLHGGSAETRSQPC--EFFAPLPEALLHDIEAQTPQL---------VE---SASGSPRRLETR--VRRDSGNPLRLL-GILRDISELAP
LQNTRDTFARAFYSSPDSITITEQSGRYLEVNEGFCQLTGYRPDEVLGRTAAQVNVWGS-AEQRQQMIVYLEEHRIHHREMLWRNKLGEQLIL--DMCVE
PMILDGVDCLLVTARDIAQLKNAQAQIQHLAYHDPLTNLPNRALLTDRLNQQVSLLRHHQLRGALMFLDLDHFKHINDSLGHPVGDSVLKIITARLEASV
RQEDTVARLGGDEFVVLISGLASREQVEQADALRQLLAEPMFLDGHRLQVTPSIGIALIPDHGTHSADLFKRADIALYRAKDSGRNTSQLFHPRMQQAAV
ERLQLENDLRLALVRNEFYLCYQAQVDARSQRIIGAEALVRWQHPERGLLNPAQFVPVLEETGMILEVGGRVLEQACKACSQLLRRGLHGFKMGVNISPR
QFHQSDFVERIEHHLLTWQLTGSMLKLEITEGMVIQNIDDTIDKMQRLKKLGISFAMDDFGTGYSSLTYLKRLPIDTLKIDQSFVRDATTDPNDAEIVRA
IIAMAQSLALHVIAEGVEHPDQLSFLQEAGCHVYQGYLFSEPLEDPAFEALLRL------
>tr|Q2BRN8|Q2BRN8_NEPCE Signal transduction protein containing membrane, EAL and GGDEF domains-like OS=Neptuniibacter caesariensis GN=MED92_06711 PE=4 
--------------------------------------------------------------------------------------------MDWFSHSS
IGVLVLDRNLNCLDC---NPFASELI-WSFNKTPNQ--HFIQPHIDSLEGDAYATHLLA-----GEHL---LLRSEFTDKGANP-RLFITLRNSS----K
QARELKVFRNAVENTGSAVVITDPKGQIEYANQRFTEITGWNLEEIKGKRPNFLRSEKTTLETYKELWGTVLNHQQWRGTLLNKRKNGSTYWSLQNISPI
HDELGNIINFVSVSEDISQIKEHDAQMEKMAYYDPLTNLGNRRSFRRTLDQYLDSPQEQ-GLNALLLLDLDHFKQINDTMGHEAGDALLTTIASRLNFCT
RQRTSVFRLGGDEFTIIFRNCNRTHVIERTNEVLSLLAQPIHIGPHEISITVSIGITLIGLDSPDASDLLRNADLAMYYAKKSGRNTFAFYEQHMDEEAQ
RTLSIEHDLRSALDGNQLRLVYQPQISADNGKITAIEALLRWDHPLDGPIPPDEFIPHAEETGLIIPIGRWVMAEACKAAKAIQDLGLPPIKVCVNLSTR
QFDDPALISHIEEAIETSGLDPRWLELEITESMLMRDMSTAIDILNSIKQKGISLAIDDFGTGYSSLSYLKKMPVDLLKIDRSFLQDIPSDRDNMAITST
IIAMTKQLGLSVVAEGVENQAQMAFLNRNQCTLMQGYLISQPVSLTQFTSNYTD------
>tr|Q58AF7|Q58AF7_RALME Diguanylate cyclase/phosphodiesterase (GGDEF and EAL domains) with PAS/PAC sensor(S) OS=Ralstonia metallidurans (strain CH34 / 
-------------------------------------------------------------------------MDTLLVSECLDL--------------T
ARRVALDQRYRDLVGVNQTVFDDDG---FLGVVTDRFPARVQGHASAIRMRKEA---CEHLPVFDAQGRYIGIVSMASAE--------FVCRSDINRRER
ELENRKISANVLESTSDAVLVTDARLRIQYINRAFTAATGYPGADIVGRPAGFLRSGRHGRGFYAEIFATLRDGGRWEGEVWLLRADGSIAPDWVTIKTV
HDEHGEVFSFVAMFADIMQRESLRAQYMHLAYYDSLTGLPNRRLFQDRLGHAIERSANKGTEFSLLFLDLNRFKDVNDTLGHSFGDRLLEVVGERFKRLV
KEADFVGRIGGDEFTFILHDTAPAQVESIARRIFDELAKPIVLNGTQSYVSASIGVSRFPADGTTAEALIMNADAAMYRAKEDGIGACHFFSRGLHTKVL
KRLDISNALHRALEANEFSLAWQPQVSLTTGKVIGAEVLLRWMRDGSVPVSPAEFIPVAEETGVIGAIGDWVLRESCRYVAKLEALAIPEFRVAVNFSPL
QLSWHR-QEPVLQTIAQFGVDCRRFKIELTENALFVHEEGLLEFVRELGAAGVGIAIDDFGTGYSNLSSLKHLPVTELKIDRAFIHDMQGSHSDRQIVQA
MISMAHMLGLRVVAEGVEYVWQVSVLREFGCEVGQGYLFSRPIDFDALVKLLDA------
>tr|G4QN46|G4QN46_GLANF Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Glaciecola nitratireducen
------------------------------------------------------------------------SFEAQYVQQRLKQDCAIPNRLIWFDELP
EGLSYLSNNEI----------DVVLL-SHFSQHRG-FNL---------VLEAAPNT-FMQTSTFDNKLTYYSTNESTTRHINYVNAQK----SSINGLRR
LFEEKERAQVTLNSIADAVLVTDNEGNVSYLNSMAEQMTGWSNEEAVGMPSDVVFHLVENSSNNPAMQ-AISENVSISANSSLIRRDGIEFPIEDSSAPI
HNRDNQVTGAVIVFRDISQSQTMANKMAHLAQHDALTGLPNRLLLKERLTQAIGAALRNQTQLALMFLDLDFFKHINDSLGHSMGDRLLVSVASRLASCI
RTTDTVCRQGGDEFVILLRTIDPQDAVHVANKLFAALAPPHHIDGNEIYVSISIGISIFPHDGHTVDQLMQSADIAMYHAKANGRSNFEFFHTEMNIRAA
QRQLVACNLRRAIEHNEFVIHYQPQIDLSTGRLSGAEALLRWKDPLLGLVYPNQFIDVAEECGLIESIGKWVMRDICTQIRKWLDIGLDAVPIAVNVSAL
ELRNLGYASGVEKILLETGLDPKYLEIELTENVLSQDFATSKLNLDALSELGVHLAMDGFGTGFSSLSYLRRFPIDILKLDRSIVRNINTSDKDTAVVSA
AISMGINLNQRIVAEGVESQAQVDFLLDHHCNIGQGYQFSYPLNANAFSRLLHT------
>tr|S7V9K3|S7V9K3_9DELT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio sp. X2 GN=dsx2_2423 PE=4 SV=1
-------------------------------------------------------------------------------VHALATAARVRG-------LM
IGSIG-AASF-----------------AL---PDT-LTI---------LLQSAASS-LE------GLELYSLLRRKNTRESARLAAQEEALRREVDAR-K
--RRLELMGQAFAHAIEAVLVCDARGRVLEANPAFNVLTGFGHEEIGGRLLRRLVVRYNGRETLRAMVAGLREKGEYAGDIACPCKNGGSFPARLSVGAV
PDGPDGTPCYVALFHDMTEDKKKEERIRYQAHHDSLTGLPNRALFQDRLGMAVARAERRNARLGVCFLDIDDFKRINDSMGHQVGDELLCDVARRLTAFM
RAGDTVARLGGDEFVIMAEDLRQADALRVCERITAAFAEPLAAGGVPHHLTVSTGVTVFPDDGVNPQMLIRNADLAMYRAKESGHGRWQLYTRQLTRQAK
KRMQTERLLRRAMERGEIEVHFQPQVDFASSRVIGAEALVRWRRK-GRLEMPAAFVPQAEESGLITLLGEEVLRQACGHAAHWRKLGH-DLRLAVNVSAR
QFEQGDLSEVVAGIIQESGFPADRLEVELTETALLRSEERVRTVLDKLCALGVASAIDDFGTGYSSLSHLRRFPIRSLKIDRGFVRDLPGDQNNASIVEA
ILSMARSLGLTVVAEGIETEDHRRFLRARGCDSYQGYLFSPPLPPEEFVRLLED------
>tr|S7TFT6|S7TFT6_9DELT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio alkalitolerans DSM 16529 GN=dsat_2171 PE=4 SV=1
-------------------------------------------------------------------------------VHALTTASRVRG-------LM
IGRLA-D-GA-----------------GL---PDA-LTI---------LLQGAASS-LE------GHELYKLLRTKNEREGRRLAVQEEALRGEVAAR-K
--GKLELLAQAFVGSLEGMIVTDASGRILEVNPAFTVMTGLSAESVIRRRMRSFLAAAEGRDQFRLMIAELSARGRFEGEVTGRRADGRLFPVWLSASAV
RGEDGRIVNYVAVFHDITERKEKEEQIRHQAQHDALTGLPNRTLLLDRLGVAMIRAMRRGCKVGVFFLDVDDFKRINDSMGHPVGDDLLRAVGQRLEQAM
RGGDTVARLGGDEFVIMADDLRQGDVARLCDRITSLFVEPFMAGGIEHHLTISMGVTVYPDDGDEPNMLIRNADLAMYKAKEGGKGRCHIYTPQLTRHAK
KRLKLERLLRRAIEKDEIEVFYQPQVDFATGQVVGLEALARWRRK-GTLVLPSEFVPLAEECGLIGAVGAVVLRQACIQGALVNGNGH-RIRVAVNVSAR
QLEQSGLVETVTESLDRSGFSPELLEIEITETALMRNEDRARVVLENLRTMGVQVSIDDFGTGYSSLSHLRRFPIKALKIDRGFIQGLPADQNSASIVEA
ILSMAKSLGLFVVAEGIETPAHHDFLRSRGCDSYQGFLFSRPLPAAELEGFLNS------
>tr|S7T7K4|S7T7K4_9DELT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio alkalitolerans DSM 16529 GN=dsat_0543 PE=4 SV=1
-------------------------------------------------------------------------------VNGADSPDGMAGPQVLSLVPI
MSRIG-DGRF-----------------LAFEIIHD-MGMLHR------WLDAAAIG-LL------LLLAYAAVRREVQQELRAYLEMENVVAERTTSL-R
--EELQLMAKVFEHSLDGISITDGDGKILRVNPAFSAITGYSPEEVMGQTPRILKSDRHDDDYYRRMWGAILSEGQWEGEIWNRRKNGEAYPEWLSISSI
TNEAGEPTHYVAVFHDISEIKRSEELMKHQAYHDALTGLPNRLLLLDRLKVAMNHSRRTGDRLALLYLDVDNFKTVNDSLGHSVGDLLLMSFAHRLKNLL
REQDTVARLGGDEFVVMVEDAEESSAVAVGERILDSLGAPFMVKGHELYVTASVGITIFPEDGDTPDALIKNADLAMYRAKETGKNNCQLFTLAMNERAQ
QRLVLEKDLRKAIEGRHFEVWYQPKVHLPTGGIIGMEALVRWRREDGSLTPPLEFIPVAEETGMIVPIGEQVLEAACRQAKTWHDSGYGHLALAVNLSVR
QLAHKGLIDFIERLLRRTDIDPSLLEFEITETAIMSRVEQAVAVLEEIRRLGAHITVDDFGTGYSSLYYLKRFPIRGLKVDRSFVSNLPSDADDLAIVRT
VVSMARGLGLHVTAEGVENVAQMETLRSLDCDFGQGYLYSPPLAAGDFERLLET------
>tr|F3EH60|F3EH60_PSEAV Sensory box protein OS=Pseudomonas amygdali pv. lachrymans str. M301315 GN=PLA107_20488 PE=4 SV=1
------------------------------------------------------------------------------TRDRLELALELAHMGTWDLDIT
GNRLQASARASALHGMAALPFDEDG--RFFGSLPAEMRAVLENQQDCL---------FQ---LQNGTSRLLESR--ARRNEGQAVKLS-GTVLDITQQCV
LEASEEKFAKAFHSSPDSITITEESGRYVEVNDGFCRLTGFSAQEVLGRTAHEIGIWSD-TVQREYMIDELRQKRVHHREMNGQDKHGAPLVL--DISVE
FITLNNTACLLMNARDIGQLKTAQAQVQHLAYHDPLTGLPNRALLMDRLSQQVSLLQHQNLRGALLFLDLDHFKHINDSLGHPVGDSVLSIIAARLEASV
RQEDTVARLGGDEFVVLICGLDTRDEVVLADNLRELLAEPMFLDGHRLQVTPSIGIVLIPDDGLAPADLLKRADIALYRAKDSGRNASQFFHVSMQQAVS
QRLRLENDLRLALTRNEFQLHFQAQIDCRDQYITGAEALLRWEHPEYGLLSPDQFVQILEESGMILEVGSHILDEACKTGGLLLKQGLNKFLMGVNISPR
QFRQNDFIERVQHSLKQHQLPASMLKLEITEGIVIQNLDDTILKMLSLKELGVSFAMDDFGTGYSSLTYLKRLPVDTLKIDQSFVQDATSDPNDAEIIRA
IVAMAQSLNLNVIAEGVETPEQLAFLERVGCYNYQGYLFSEPLPGPQFENLLLK------
>tr|K2SYN6|K2SYN6_PSESY PAS:GGDEF domain-containing protein domain-containing protein OS=Pseudomonas syringae pv. avellanae str. ISPaVe037 GN=Pav037_44
------------------------------------------------------------------------------TRDRLELALDLAQMGTWDLDIV
RNRLQASARAALLHGMPARPFDEPG--GFFGSLPAEMRALLETGQDCL---------FQ---LKNGTSRLLEGR--ARRDEGQPVRLA-GTLMDITQQCA
LEASEEKFAKAFHSSPDSITITEDSGRYVEVNDGFSRLTGFSAHEVLGRTAHEVGIWTD-TLQREHMLEELRQKRVHHREMDGRDKHGAPLVL--DISVE
FITLNNTACLLMNARDIGALKNAQAQIQHLAYHDPLTGLPNRALLLDRLSQQVSLLQHQNLRGALLFLDLDHFKHINDSLGHPVGDSVLSIIAARLEASV
RQEDTVARLGGDEFVVLICGLESQDEVELADNLRNLLAEPMFLDGHRLQVTPSIGVVLIPDDGLTAADLLKRADIALYRAKDCGRNASQFFHVSMQQAVS
QRLRLENDLRLALTRNEFHLHFQAQVDCRNEYITGAEALLRWQHPEYGLLAPDQFVQILEESGMILEVGSHILNEACKTGGLLLRQGLNRFLMGVNISPR
QFLQHDFIERVERSLTLNQLPASMLKLEITEGIVIQNLDDTILKMLSLKALGVSFAMDDFGTGYSSLTYLKRLPVDTLKIDQSFVQDATSDPNDAEIIRA
IVAMAQSLNLNVIAEGVETSEQLAFLEKVGCYTYQGYLFSEPLPGPQFESLLQL------
>tr|F3DVC6|F3DVC6_PSEA0 Sensory box/GGDEF domain/EAL domain-containing protein OS=Pseudomonas amygdali pv. morsprunorum str. M302280 GN=PSYMP_11212 PE=
------------------------------------------------------------------------------TRARLELALDLAQMGTWDLDIT
RSRLQASARASFLHGMDAQPFDDDS--RFFERLPAEVRAALESRQDCL---------FQ---MKDGTSRLIESR--ARRDEGNPVKLS-GTLLDITQQCV
LEASEEKFAKAFHSSPDSITITEESGRYVEVNDGFCRLTGFSAREVLGRTAHEVGIWTD-TVQREYMIDELRQKRMHHREMNGRDKNGAPLVL--DVSVE
FITLNNTACLLMNARDIGQLKSAQAQIQHLTYHDPLTGLPNRALLMDRLSQQVSLLQHQNLRGALLFLDLDHFKHINDSLGHPVGDSVLSVIAARLEASV
RQEDTVARLGGDEFVVLICGLDSLEQVVLADNLRVLLAEPMFLDGHRLQVTPSVGIVLIPDDGLTPADLLKRADIALYRAKDSGRNASQFFHVSMQQAVS
QRLRLENDLRLALARNEFHLHFQAQVDCRTNQITGAEALLRWQHPEYGLLPPDQFVQILEESGMILEVGSRILDDACKIGGLLLSQGLDRFLMGVNVSPR
QFRQSDFVERVEHSLKQHHLPATMLKLEITEGIVIQNLDDTILKMRSLRDLGVGFAMDDFGTGYSSLTYLKRLPVDTLKIDQSFVQDATSDPNDAEIIRA
IVAMAQSLNLHVIAEGVETPEQLAFLERVGCYNYQGYLFSEPLPGPEFETLLQL------
>tr|W0MPT2|W0MPT2_PSESX Diguanylate cyclase OS=Pseudomonas syringae CC1557 GN=N018_09235 PE=4 SV=1
------------------------------------------------------------------------------TGDRLELALDLAQMGTWDLDTT
SNRLRASARTAFLHGMEAQPFDDDA--EFFGKLPVEMREAIENRNDHL---------FQ---LKNGTSRLIESR--ARRDDGQLSRMA-GTLMDITEKRA
LEASEEKFAKAFHSSPDSITITEESGRYVEVNDGFCRLTGFSAQEVVGRTAHEIGIWTD-TLQREFVINELRQKRVHHREMSGHDKHGNPLTL--DISVD
FITLNDTACLLMNARDIGQLKDAQAQIRHLAYHDSLTGLPNRALLIDRLSQQLSLLQHQNLRGALLFLDLDHFKHINDSLGHPVGDSVLNVVAARLEASV
RQEDTVARLGGDEFVVLICGLDALDEVMLSDNLRELLAEPMFLDGHRLQVTPSIGIALIPDDGLTPADLLKRADIALYRAKDTGRNIAQFFHASMQQAVS
QRLRLENDLRLALTRNEFQLYFQAQVDCRTNQITGAEALLRWQHPEYGLLPPDQFVQILEESGMILEVGSRILDDACKIGGMLLSQGLDRFLMGVNISPR
QFRQNDFVERVERSLKQHQLPATMLKLEITEGIVIQNLDDTILKMRRLRDMGVGFAMDDFGTGYSSLTYLKRLPVDTLKIDQSFVQDAASDPNDAEIIRA
IVAMAQSLNLHVIAEGVETTEQLAFLEKVGCYNYQGYLFSEPLPGPQFESLLQL------
>tr|F2ZNN1|F2ZNN1_9PSED Sensory box/GGDEF domain/EAL domain-containing protein OS=Pseudomonas coronafaciens pv. oryzae str. 1_6 GN=POR16_20007 PE=4 SV=
------------------------------------------------------------------------------TGDRLQLALDLAQMGTWDLDVV
SNRMQASTQTAYLHGMGAQPFDDDA--EFFSRLPTEICDAVDNHDDYL---------FQ---LIDGSSRLLESR--ARRDAGQLSRLA-GTLMDITQKRA
LEASEEKFAKAFHSSPDSITITEDSGRYVEVNDGFCRLTGFSAQEVVGRTAHEIGIWTD-TLQREYMIDELRLKRVHHREMNGRDKNGDPLVL--DISVD
FITLNETACLLMNARDIGQLKNAQAQIHHLAYHDPLTGLPNRALLMDRLGQQLSLLKHQNLRGALLFLDLDYFKHINDSLGHPVGDSVLNVVAARLEASV
RQEDTVARLGGDEFVVLICGLDSLDEVVLSDNLRVLLAEPMFLDGHRLQVTPSIGIVLIPDDGLTPADVLKRADIALYRAKDAGRNTSQFFHVSMQQAVS
KRLQLENDLRMALTRNEFHLHFQAQVDCRDNQITGAEALLRWQHPEYGLLPPDQFVQILEESGMILEVGSRILDDACKIGGLLLSQGLDRFLMGVNISPR
QFRQNDFVERVEHSLKQHQLPASMLKLEITEGIVIQNLDDTILKMRSLKSLGVSFAMDDFGTGYSSLTYLKRLPVDTLKIDQSFVQDAANDPNDAEIIRA
IVAMAQSLKLNVIAEGVETPEQLAFLEKVGCYNYQGYLFSEPLPGPEFESLLQL------
>tr|A0A0D0M5N9|A0A0D0M5N9_PSEVI Strain LMCA8 contig_72, whole genome shotgun sequence OS=Pseudomonas viridiflava GN=RT94_26830 PE=4 SV=1
------------------------------------------------------------------------------TLDRLNLALSSAQMGTWEWDIA
TDQLHACARAAQLHGREARSLDYDF--TFLAGVPTVMRSAVAGEQDTF---------FQ---LQNGLSRLLESR--AIRNAGTPSRLV-GTLLDITQQQA
LEASEEKFAKAFHSSPDSITITEGTGRYVEVNDGFCRLTGYSAPEVLGRTVQEIGIWTD-PDQRQSMIDQLRDARVHHREMAGRNKNGDPLTL--DVSVE
FITLNQTACLLMNARDIGQLKSAQAQIQHLAYHDPLTGLPNRALLMDRLSQQLSLLKHHRLRGALLFMDLDHFKHINDSLGHPVGDSVLNIVSARLEASV
RLEDTVARLGGDEFVVLICGLESRHEVELSDNLRELLAEPMFLDGHRLQVTPSIGMVLIPDDGSTPADLLKRADIALYRAKDSGRNTAQFFHSSMQKAVS
QRLRMENDLRLALTRNEFHLHFQAQVDCRNQALTGAEALLRWQHPDYGVLPPTQFVQILEESGMILEVGSWVLDEACKTAGRLLKQGLNGFLMGVNISPR
QFRQTDFVARVERSLKLHKLPATMLKLEITEGIVIQNLEDTIAKMRSLKKLGISFAMDDFGTGYSSLTYLKRLPVDTLKIDQSFVQDATSDPNDAEIIRA
IVAMAQSLNLNVIAEGVETVEQLAFLEKLGCHVYQGYLFSEPLGDSQFEALLRL------
>tr|W0HBT3|W0HBT3_PSECI Histidine kinase OS=Pseudomonas cichorii JBC1 GN=PCH70_31020 PE=4 SV=1
------------------------------------------------------------------------------LRDRLEMALGAAQMGTWDWHIP
SDTLHASAQAAQLHGMSAQPFNDTL--HFFTDVPAEMRQALDSQDDSF---------LQ---LKNGALRLLEGR--AHRDEGAPLKLS-GTLLDITQQHA
LLASEEKFAKAFHSSPDSITITEESGHYVEVNDGFCRLTGFTSQEVLGRTALEAGLWVE-PEQLRQVTDQLRTTKIHHMEMSGRHKNGTPLVL--DISAE
LITLNETACLLVTARDISELKHAQAQVQHLAYHDPLTNLPNRAMLMERLSQQLTQLKQDNLRGALLFLDLDHFKHINDSLGHPMGDCVLTIVTARLEASV
RLEDTVARLGGDEFVVLIGGLESRHEVDLADNLRKLLAEPMFIDRQRLQVTPSIGIALIPDHGSNPADILKRADIALYRAKDSGRNAAQLFHRSMQKAAS
QRLRMENDLRMALTRNELHLYYQAQVNTQSDRIIGAEALLRWQHPDYGLLAPTQFIQILEESGMILEVGGWALEEACKVGGRLLQQDLNDFLLAVNISPR
QFRQTDFVEQVESCLKRHRLPPTMLKLEITEGIVIENLDDTIAKMLRLKKIGVSFAMDDFGTGYSSLTYLKRLPVDVLKIDQSFVHEAATDPNDAEIVRA
IVGMANSLNLSVIAEGVETVEQLAFLEQLNCHTYQGYLFSEPLPPAEFEALLCL------
>tr|L7HFN7|L7HFN7_PSEFL Sensory box/GGDEF domain/EAL domain-containing protein OS=Pseudomonas fluorescens BRIP34879 GN=A986_12834 PE=4 SV=1
------------------------------------------------------------------------------SQERLDLALESAQLGTWDWHIP
TGMLYGSARAAQLHGLPPESFHEPF--EFFEGMPDSMRSARKGPAGNY---------VP---LEDGSARYLESR--ARRDEGAPLRMA-GTLLDITDQVE
LTASEEKFASVFHASPNAISITEDTGRYVEVNDGFCRLTGYRAEEAIGLTLYQIGIWAD-ENQRSALLAELAIKRIPHLEMLWHNRRGEVLSV--EVSVE
PITLNQTPCLLLTARDVSLLKNAQAQVRHLAYHDPLTSLPNRALLMDRLSQQIALLKRHNLRGALLFLDLDHFKHINDSLGHPVGDTVLKMITARLEASV
RMEDTVARLGGDEFVVLLSGLESRTQVDLAETLRRLLSEPMFLDGHRLQVTPSIGVALIPDHGSTPTDLLKRADIALYRAKDSGRNTTQMFHNSMQKAAS
ERLRMETDLRLALARGEFSMHYQPQVDARGNRIVGAEALVRWQHPQLGAQSPAEFIKVLEDSGLILEVGTWILDEACAGVAQLIADGLLNFSLCVNISPR
QFRQNDFVERVEHSLKHYELPFSLLKLEITEGIVIQNLDDTVLKMRRLKKLGVSFAMDDFGTGYSSLTYLKRLPVDALKIDQSFVRDATHDPNDAEIIRA
IVAMARSLNLEVIAEGVETLAQLAFLQGLGCHLYQGYLHSRPLPIERFRTLLM-------
>tr|D6Y0T0|D6Y0T0_BACIE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS
--------------------------------------------------------------------------------TNLDGFFEKSPFAVMVISSD
QEVVYTNGEFEVLFGYEREEVIGMS---VASLFHYGKVRTEAKAAAYAVLRGETVSKQTERHNRFGEAVPVTLYAYPLRSE-TGVSGAVVAYLDRRQDVA
NEETVKLFEMSLRNISDGVMITEQDGTILWVNRAFEVITGYTSEEAIGNNPRLLNAGVHSKAFFRQMWKALEDRGVWRGDIWNRRKSGSVYRQRLSVSKF
RGSADE-RLYIAVIHELSDLDDMQDKLTILETTDPVTGLPNRPEMRKLIERKVNHSDYISDRFAVLTIEITNFNEMNDTLGHKVGDRLLIDIAKRLMLLV
NDESQVGRIGGDDFLIVHDQ--QGDLEPFLEKLVTCLEKPFFVDDSELFIHPSIGVSRFPEDCEETQNLFMTSNVAMTHARESVVDHISYFSTEKAEELK
RRFEIANHLKGAGKREEWALHYQPIVDLESGELKKAEALIRWSNKDLGIVSPGEFIPIAEKTGQIIAIGEWVLDEVFRQLIKWGMEGLVIVPVSVNLSIR
QLEQENFAESLLKRMRDWRIPADYLQVEITESMTKGNIGRIMKNLNRLTRAGVRVAIDDFGKGYSSFSHLTELGLSELKVDQHFIKAMRQETETEKLLRA
MLLVADGLGLDTVAEGVETDFHHEKVKALGFTLGQGYYYAKPLPEKDFRNWL--------
>tr|Q1NQ51|Q1NQ51_9DELT PAS:GGDEF:EAL OS=delta proteobacterium MLMS-1 GN=MldDRAFT_4169 PE=4 SV=1
--------------------------------------------------------------------------------ERFRNTET-SNDWIWEVDTS
GSYTYVSPQVKTLLGYRPDEVIGRT---PFDFMPSGEA---ERVRDFAAISAEQEAIVNTNLHRQGRRVILETSGVPFYDQHGTWQGYRGIDRDITVRQQ
LEEWLRQSAMVYENMWEGAVITDPAGTILDVNPAFSRITGYAKDEVIGKNPRILKSDRHEQAFYQHMWRELIEKGQWRGEIWNRRKNGEVYPEWLSISGV
SDARGQTSYYVGVFTDLSQLKQSEAKLESLAYYDPLTALPNRLLLHSRLEHALEWAERHQTKVGVYFIDLDQFRVVNESLSYQAGDQLLVMVSKRFLSCL
RVDDTLARPGGDEFVLIQEALADQEATETARELLASLDQPFQLGGQEIYLGASIGITVFPGDGTTPPDLLKNAEAAMYHAKENGRNRFSFYAEQMNADAL
ARLQMEMALRQAVENRELLLYYQPQWQLADPSVIGAEALIRWRNKEGELIAPDQFIPLAEKSGLIGAIGDWVIDEACRQLRIWRDQGKKQLRVAVNVSAR
QFRAGNLAEVVAQALRKHEIPAHCFELELTESILMEKPEEAAELLNRCAALGVGIALDDFGTGYSSLAYLSRFPITVLKIDRSFVRDLNHRSEAALIADS
IIALAHRMGLQVVAEGVETEEQRAYLQSRGCDLAQGFLFSPPLPAEQFAEFS--------
>tr|Q47V32|Q47V32_COLP3 Sensory box/GGDEF family protein OS=Colwellia psychrerythraea (strain 34H / ATCC BAA-681) GN=CPS_4696 PE=4 SV=1
--------------------------------------------------------------------------------KGLA--QGEIDTGILVLNLN
GELEEVNEQFLAMTGFLKENVLGQN---IDEIDNC---SAKKILSGSAI----YGHYLTRKDGSNLQVETCYFRQQTQNS----AQILLFIQE---SNYA
ELTKTSIIEQIFDHTNEAIIVTDNQGLIQTVNKSFSNITGYSEEEVIGKTPAILNSGKQDKYFYKKFWQQIIDQGSWQGEIWNKRKNGEVYPEWLNISSI
RNKESQISNYICQFTDITNRKKSEEELHFHAYHDSLTSLPNRHLLFEKLNHLCVLHQEQPTYFAVLFCDLDRFKMINDSLGHDVGDELLKSVANRFEAKL
RDNDIIARTGGDEFIVVIEGEKAKNLDKICLQILSLFEVPFQTKYGEFKTTISIGVSQFPSDSEDVRELISFADVAMYKIKKSGGNHYSFFDVKEKALIQ
QRLELESEITQAIEKDQFAVWYQPQVNTQTHEVYGVECLIRWNHPEQGLIPPDLFIPIAEANGSIKELGYFVLKTACQQLRQWRIKNIFTGVMAINVSLR
QFERNDLLAQVKKTLVDEMLPAESIELEVTESLFSEDNNYHTPILCALRELGVKVAIDDFGTGYSSLQRLKSLPIDNVKIDKCFVDNIEHCPEDVAIVMA
TILLSKTFKVDVIAEGIETQEQADKLSDLGCFNQQGYLYSRPLKAHDFEVWL--------
>tr|U7FM99|U7FM99_9ALTE Uncharacterized protein OS=Marinobacter sp. ES-1 GN=Q666_03830 PE=4 SV=1
--------------------------------------------------------------------------------ARLAL-ATTTSNMVLILDGE
ARIEWVNGAFEAHTGYPLTDIRGKK---PFDLLPGTGTDKETVARIAHFANGEPF-E--LHYTASGTPYWVHTCSMPIGKAEGVDPGFVIIQTNISDRKH
GERGLRIAASVFDRSHEAILITDKHNRIMDVNPAFARITGYSREEVLGLNPNILSSGRHSKAYYQSMWRSIEQNDFWRGELWNRRKNGEEYVELLSVSRV
HLEEPGQYFHVASFSDITALKNHARDLDRAANYDELTGLPNRQLLVERLRTARQHADRQKRSLSVCYLDIDGFKAINDEFGHDAGDKALKTVADRLAHSL
RRGDTIARIGGDEFVILVQS----NPEIVYQRLLAEVSQPIPVADTFITVTASLGAAIYPDDNTDAEGLIRHADQAMYAAKEKGRNQFHIFDPGEDAFRR
QRRNQLVEIGNALEHNEFELYFQPQVRLADYQVVGFEALIRWNHPARGLTTPGEFLPAVENSHLEVPLGSWVLKEAIHQMNLWNEAGEQLAV-SINIGAP
HLMDRSFVHYLESYLQSHEVNPEQITLEVLESTALEDIQRAENVLAKCQTLGLQVALDDFGTGFSSLTYLRTLPINMIKIDQSFIRDMLQDDSDRAIVES
VIFMAQRFEKPTLAEGVETMAQAEALMAMGCNLVQGYAVARPMPASEVLPWL--------
>tr|A1TXD5|A1TXD5_MARHV Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Marinobacter hydrocarbonoclasticus (strain ATCC 700491 / DSM 11
--------------------------------------------------------------------------------KRLAL-ATASRNMALILDAG
GCIEWVNQAFEEHTGYSLSAVRGKL---PSQVLAGPDTDPDTVSRIRHLFRGEAF-E--LHYTASGEPYWVHTYCTPVDGADGVEPGFVVIQTNISDRKN
SERGLRIAASVFDRSHEAIVITDHLNHIIDVNPAFSRITGYSRQEVLGLNPSILSSGRHSREYYRSMWQSIEKTDHWRGEVWNRRKNGEEYVELLSISRV
HLEEPGKHYYVAAFSDITALKNHAKELDRAANYDDLTGLPNRQLLEERLRSAKAHADRQKRSLAICYLDLDGFKGINDELGHDFGDEALRMVAERLTRSL
RSGDTVARIGGDEFVLLIQG----HSEPLYQRILTSVSEPFELADKEVNLTASLGVTLYPEDDTDAEGLVRHADQAMYAAKEKGRNQFHIFDPGQYAFRK
ERRNQLMEISRALENEEFELYFQPQLRMADCQVIAFEALIRWNHPEKGLIAPGAFLPAVANSHLEIPLGQWVLKEAIHQMNRWREAGEALAV-SINISAP
HLMDRKFVDYLEGYLQSHEVSPGQITLEVLESTALEDTKRASNVLARCQSLGLQVALDDFGTGFSSLTYLRTLPVDVIKIDQSFVRNMLTDANDRAIVES
VIFLAQRFDHPVLAEGVETMDHAAALRDMGCNLVQGYGIARPMPSGAVLEWL--------
>tr|E4PKS2|E4PKS2_MARAH Diguanylate cyclase/phosphodiesterase OS=Marinobacter adhaerens (strain HP15) GN=HP15_3980 PE=4 SV=1
--------------------------------------------------------------------------------KRLAM-AAATPNFLVMLDDA
GRIEWVNPSFEEHTGYQLEEVRGCL---PKEVLYGPDTDPETIKRIQKLHRAEII-E--LHYTKAGQPYWVHTYCVPIGTEQGVAPGYIAIQNNISDRKN
SERGLRIAASVFDRSHEAILITDQSNRILDVNPAFSRITGYSRQEVLGLNPAILSSGRHSGAYYRSMWRTIEKTDHWRGEIWNRRKNGEEFVELLSISRV
HLEEPGQYYHVAAFSDITALKNHARELDRAANYDDLTGLPNRQLLEERLRTARSHADRQHRSVSVCYLDLDGFKGINDKWGQSAGDQTLRTLAERLTRAL
RSGDTVARIGGDEFVLLLQG---DNHEAVYQRILATVGDPVTVGDQNVSLTASLGITRYPEDGSDAEGLIRHADQAMYSAKEKGRNQYHLFDPGLDEHRR
NRRNQLMEISRALENEEFELFSSPRSVS-RIANFSVLRRIRWNHPQKGLVSPGEFLPIVENSHLEVPLGQWVLKEAIHQMNAWKEAGENLAI-SINISAP
HLMDRSFADYLESYLHSHEVAPGQITLEVLESTALEDTQRASNVLARCQSLGLQVALDDFGTGFSSLTYLRTLPVDIIKIDQSFVRNMLEDAGDRAIVES
VIFLAQRFAHPVLAEGVETMEHARTLRQMGCNFVQGYGIARPMPAAEVLGWA--------
>tr|M7CQE1|M7CQE1_9ALTE Diguanylate cyclase/phosphodiesterase OS=Marinobacter santoriniensis NKSG1 GN=MSNKSG1_16231 PE=4 SV=1
--------------------------------------------------------------------------------KRLTL-AAATPNLLLILDAA
GCIDWVNPSFEEHTGHLLADIRGKQ---PKDVLYGPDTDPDTAARIRKLHLGDVF-E--LHYTRSGTPYWVHTFCMPVGEKQGVAPGYIVIQNNISDRKH
SERGLRIAASVFDKSHEAILITDRNNRILDVNPAFSRITGYAREEVLGLNPAILSSGRHSPGYYRSMYQSIEKTDHWRGEIWNRRKNGEEYVELLSISRV
HLEEPGQYYHVAAFSDITALKNHARELDRAANYDDLTGLPNRQLLEDRLRTASQHADRQQRAISVCYLDIDGFKTINERLGHAAGDQALRTVAERLTRTL
RSGDTVARIGGDEFILMLQS----ASEHVYQRILSTVSEVMEIGGKDVTLTASLGITRYPDDNADPEGLIRHADQAMYSAKEKGRNQFHFFDPGLDEHRR
QRRNQLTEITRALENDEFKLYFQPQIQVDNGAIVGVEALIRWQHPDHGLLNPAQFLPAVDNSHLEVPLGQWVLKEAIHQMNAWQAEGLSLAV-SINISAR
HLMDRSFVDYLESYLHSHELNPSRVTLEVLESAALEDTNRASNVLNRCRSLGLQIALDDFGTGFSSLTYLRTLPVDVIKIDQSFVLNMLDDANDRAIVES
VIFLAQRFAHPVLAEGVETMEHARLLRDMGCNLVQGYGIARPMPATDLPAWV--------
>tr|R8AY28|R8AY28_9ALTE Diguanylate cyclase/phosphodiesterase OS=Marinobacter lipolyticus SM19 GN=MARLIPOL_14495 PE=4 SV=1
--------------------------------------------------------------------------------PRLAL-AAYTPNMVMITDDA
GCFEWVNPSFEKHTGYALSDLKGKR---VGDVLFGEDTDPQTVRRIQKLYENAAF-E--LQYTRSGAPYWVHIHGFPIGQEQGVKPGFIAIQNNISDRKN
SERGLRIAASVFDRSHEAVLITDHNNRILDVNPAFSRITGYSRNEVLGLNPAILSSGRHTPEYYRSMWHTIEQTDHWRGEIWNRRKNGEEYAELLSISRV
HLDQPGQFYHVAAFSDITALKNHARELDRAANYDVLTGLPNRQLLEERLRTARSHADRLRRGLSVCYLDLDGFHTVNERFGHTAGDEALKTLAERLTRTL
RSGDIVARIGGDEFVLLLQS----TTDPVFQRILSTVGVPLTLGDESVTLTGSLGITRYPDDNSDAEGLIRHADQAMYSAKEKGRNQFHFFDPCLDEHRR
KRRSQLMDITRALENEEFELYFQPQIHLPDGAITGFEALIRWNHPELGLLAPGSFLPAVENSHLEVPMGQWVVKEAIHQLNRWREAGTPLAI-SINISAQ
HLMDRSFTDFIETYLRLHDLDPGLITLEVLESTALEDTQRAGNVLSRCRCLGLKVALDDFGTGFSSLTYLRTLPVDMIKIDQSFVFNMLEDASDRAIVES
VIFLAQRFAHPVLAEGVETIAQAHALKQMGCKFVQGYGIARPMPADDVLDWT--------
>tr|A0A072MZD5|A0A072MZD5_9ALTE Diguanylate cyclase OS=Marinobacter sp. AK21 GN=D777_03239 PE=4 SV=1
--------------------------------------------------------------------------------GRLAS-AFATRNLVVILDEA
GMIEWVNPSFEEQTGYHIDNIRGKA---PRDVLYGPDTDPDTIKKFRALFRGEST-S--LNYTRSGQPFWVHCLCKPIEPVQGARAGFVAILNNISDRKN
GERNLRIAASVFDRSHEAIIITDRNNRILDVNPAFSRITGYGREEVLGLLPSILSSGRHSREYYQSMWHTIETTDHWRGEIWNRRKNGEEYIELLSISRV
HLEEPGQYYHVAAFSDITTLKNHAKELDRAANYDELTGLPNRQLLEERLQSAKAYADRQKRTLSICYLDLDGFKSLNERFGKAEGDRILKTTAERLTHTL
RSGDTVARVGGDEFVLLLKS----GHESVYQRILATVAEPLSAQDQTISLTASLGITRYPEDQGDAEGLIRHADQAMYSAKEKGRNQYHLFDPDLNEFRK
QRREQLTEIARALENDEFCLYFQPQIRLSDNRLMGFEALIRWQHPEHGLLAPGQFLPTLENSYLEVPLGQWVLKEAIHQMNIWREAGHRFGV-SINISAQ
HLMDRSFADYLESYLHSHGLDPGLVTLEVLESTALEDTKHASNVLSRCREMGLQVGLDDFGTGFSSLTYLRTLPVDMIKIDQSFVLNMLTNANDRAIVES
VIFLAQRFSRPVLAEGVETPDHARALRSMGCDQIQGFGIARPLPAGEVLAWA--------
>tr|Q5NWP7|Q5NWP7_AROAE Azoarcus sp. EbN1 plasmid 1 OS=Aromatoleum aromaticum (strain EbN1) GN=p1B362 PE=4 SV=1
--------------------------------------------------------------------------------M-YRL-VNEISDGILVLDAD
FVARFANPAMLRILGYSPDELDGVW---AGDLVWSEAEDLGRFAEEEKRRRGESGNY--RWRRKDGSARWSRISATARF-DPGQFDGSLIVFQDITERKR
TDEALRLWASVFANSREGIAITDRNGIILDVNEAFVRITGYGREEVIGQNPRILQSGRHDSAFYAGMWESLYKASNWCGEIWNRRKDGEIYPQWLNISAV
RDEESEVSHYISVFMDLSQIKSNEKRLELLAYFDPLTGLANRTLLADHMRMAIARSRRESTLFALGYLDLDGFKPVNDQFGHEVGDQFLQEIAKRIKSVV
RGDDTVARLGGDEFVILVQGLRKEECHHTFERLLAKLEEPIQLNGHHLTATGSIGVTLFPCDEADPDTLLRHADHAMYQAKEAGKNRIHLYDTEFDVEVR
VQRELVERIEHALSEREFLLFYQPKVDLRRGRVIGVEALIRWQDPDRGLLPPSAFLPQIQNHLVSQKIDQWVLSEAVAQLMLWHAIGLDLSI-SVNVSGL
SLQTHDFMNTLAKLLAAHEINRSRLEIEVLETVALDDIEHISGIISRRQAEGIRFALDDFGTGYASLRYLKHLPADVLKIDQSFVRDMLNDEEDRVIVEG
VIGLSRAFKREVVAEGVETLEHYLCLMELGCDFAQGFGIARPMPASEFLPWL--------
>tr|G4QE75|G4QE75_GLANF Sensory box protein OS=Glaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064) GN=GNIT_3255 PE=4 SV=1
--------------------------------------------------------------------------------MYLHA-FNNTGDPIFVKDED
FKFILVNDACCRFFGLSRDEIIGST---LAESFPSE-EMEGFFSIDKVLEEGKEILS--LSSAKIGSKR--VLTRKNRFVDHGKFF-IVGVVHDITQRQK
TEEKLKRAASVFIHAHEGIMITDASAAITEVNDSFSRITGYSSEEVLGHNPRIFQSGRHLPEFYTEMWGKLIAQGYWEGEIWNRRKNGEIYPSMLTISAV
KNQADEIQHYVSLYSDITSIKEYQNQLEHIAHFDLLTNLPNRVLLADRLSQAMLQCQRHQQSLAVVFVDLDGFKQVNDTNGHDVGDELLIAISVRMKEAL
REGDSLARIGGDEFVAVLADLSSDNAEPILKRLLLAASKPVTVDGLILKVSASIGVTFYPQDDVDADQLMRHADQAMYAAKEAGKNRYCFFDTDRDNAFR
VQQESLEAIHSGIDNHQFVLHYQPKVNMREGKVIGVEALIRWQHPKRGLLDPIEFMHAFENNSTSVKMGEWVIDKALAQISQWQKIGLNLPVTSVNIAAA
QLQQPDFVNSLVTLLATHDVDPSFLQLEVMETNALYDVNRVSAIMNGCMALGVNFALDDFGTGYSPLIYLRKLPASTIKIDKSFVQNMLSDKDDLAIVEG
VIALAKSFKRDVIAEGVETIQHGTVLMQLGCNLAQGFGIARPMPAADIPAWV--------
>tr|L7H001|L7H001_PSESX PAS:GGDEF protein OS=Pseudomonas syringae BRIP39023 GN=A988_11854 PE=4 SV=1
--------------------------------------------------------------------------------EKFAKFHASPDGMAITRQQD
GMLLEVNEGFCRLTGYSEKYCLEHS---TFDLGIWVDLSERSRLIEMKQ----HGFVRVRIRNSNGDVRLCELSSQPVII--AGEDCLLTTTRDITESRQ
MQEKLHLAATVFESTAEGVLITNTDQTISAVNRAFTEITGYSEAEAIGKTPRLLASGQHDSAFYAAMWHQLAAEGHWQGEISNRRKNGELYPSWLTISAV
RNKDNLLTHFVAVFADISSLKHAQARLDYQAHHDPLTGLPNRTLFENRLQAALLHSEESGSLGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAHRLKETL
RDIDTVARLGGDEFIVLLPGLLQSDAQAIANKLLACFNTPFEAGEHELYISPSIGSCVFPTDGTDVATLVKNADAAMYRSKAKGRNRVESYTCDLSDQAS
ERIALEQELRRALERNQLTLAYQPKINLTTHTLAGAEALIRWNHPTFGDVPPEHFIPLAEENGMILQIGDWVLEQACRQMGVWRKTCQPFGPLSVNLAGA
QLRQTNLLERIEQLLTDNGLEPGCLQLEITENFIMSQTQEALAVLHQLKTLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFVRGLPEDTHDAAIVRA
IIALGRSLQLTVIAEGVENSEQQQFLTSEGCEQIQGYIVSLPLDAEEFRERF--------
>tr|A0A0E2UYB9|A0A0E2UYB9_PSESF Sensory box/GGDEF domain/EAL domain-containing protein OS=Pseudomonas syringae pv. actinidiae ICMP 9617 GN=A250_01785 PE=4 SV=1
--------------------------------------------------------------------------------EKFAKFHAAPDGLAITRQQD
GMLLEVNEGFCRITGYSELHCLEHY---TFDLGIWADLSERSKLTELEQ----HGVVRARLCNVNGSIRVCELSSHPLLI--SGDACLLTISRDITESQL
MQEKLHLAATVFESTAEGVLITDTDQRISAVNRAFTEITGYSESEAIGQTPRLLASGQHDSAFYASMWHQLTAEGHWQGEISNRRKNGELYPSWLTVSAV
RNKENLLTHFVAVFADISSLKHAQARLDYRAHHDPLTGLPNRTLFESRLQSALLHSEESGSLGAVLFLDLDRFKHINDSLGHPIRDLLLKGIAHRLKETL
RDIDTVARLGGDEFIVLLPGLLQSDAKAIANKLLACFSTPFEAGEHDLYISPSIGSCVFPTDGTDVATLVKNADAAMYRSKAQGRNRVESYTRDLTEQAS
ERIALEQERRRALDRNQLSLAYQPKISILTHTLVGAEALIRWSHPTFGEVPPEHFIPLAEENGMILQIGEWVLEQACRQMGAWRKTCKPFGPMSVNLAGA
QLRQPNLVERIEQLLTDNGLMPDCLQLEITENFIMSQTQDALAVLHKLKQLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFIRGLPEDTHDAAIVRA
IIALGRSMQLTVIAEGVETREQQQFLSEEGCEQIQGYIISLPLQPDEFSERF--------
>tr|F3HPR8|F3HPR8_PSEYM Sensory box/GGDEF domain/EAL domain-containing protein OS=Pseudomonas syringae pv. maculicola str. ES4326 GN=PMA4326_21297 PE=4
--------------------------------------------------------------------------------EKFANFHATPDGLSITRQND
GMLLEVNEGFCRITGYSEQYCLEHS---TFDLGVWADLNDRHTMIELKS----HGQVRTRLRDASGNIRICEVSSQPLVI--AGEDCVLTITRDITQHQQ
MQEKLHLAATVFESTAEGVLITDTDQRITAVNRAFTEITGYGESDAIGLTPRLLASGQHDSAFYASMWHQLTAEGHWQGEISNRRKDGELYPSWLTISAV
RSKDGLLTHFVAVFADISSLKQAQARLDYQAHHDPLTGLPNRTLFENRLQSALLHCEESGGLGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAHRLKESL
RDIDTVARVGGDEFIVLLPGLLQSDALTIANKLLACFNAPFEAGEHELFISPSIGSCLFPDDGTDVATLVKNADAAMYRSKAKGRNRVESYTRDLTVQAS
ERIALEQELRRALDRNQFSLAYQPKICLLTQALVGAEALIRWSHPTFGDVPPENFIPLAEENGMILQIGDWVLEQACRQMGKWRKTRQPFGPLSVNLAGA
QLRQPNLVEHIETLLADNGLIPGCLQLEITENFIMSQTQEALAVLHKLKTLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFVRGLPDDTHDAAIVRA
IIALGRSLQLTVIAEGVETREQQQFLASEGCEQMQGYLTSLPLPAEEFSARF--------
>tr|A0A0B8V6U9|A0A0B8V6U9_9PSED Diguanylate phosphodiesterase (Fragment) OS=Pseudomonas coronafaciens GN=OA77_02505 PE=4 SV=1
--------------------------------------------------------------------------------EKFAKFHASPDGLGITRQLD
GMMLEVNEGFCQITGYDEQYCLEHS---TFDLGIWADLNERYQLIEMKR----NGSVRARLRTASGAIKLCELSSQPLII--AGEECLLTISRDITQSQQ
MQEKLLLAATVFESTAEGVLITDTFQRISAVNRAFTEITGYSESDAIGQTPRLLASGHHDSAFYASMWHQLTAEGHWQGEISNRRKNGELYPSWLTISAV
HNKENLLTHFVAVFADISSLKQAQARLDYQAHHDPLTGLPNRTLFESRLQSALLHSEESGSLGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAHRLKETL
RDIDTVARLGGDEFIVLLPGLLHSDAKAIATKLLACFSTPFELGEHELYISSSIGSCVFPTDGTDVATLVKNADAAMYRSKAQGRNRVECYTRDLTEQAS
ERIALEQELRRALDRNQLSLAFQPKISLLDGTLVGAEALIRWSHPTLGEVPPEHFIPLAEENGMILQIGDWVLEQACLKMGKWRKAFKLFGPVSVNLAGA
QLRQPNLVERIEQLLADNGLVPNCLQLEITENFIMSQTQEALAVLHKLKNLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFIRGLPEDTHDAAIVRA
IIALGRSMQLTVIAEGVENSEQQKFLTDEGCEQIQGYIISLPLNPDEFSTKF--------
>tr|A0A085V1G8|A0A085V1G8_PSESX Diguanylate phosphodiesterase OS=Pseudomonas syringae GN=IV02_19600 PE=4 SV=1
--------------------------------------------------------------------------------EKFAKFHSSPDGMLITRQSD
GLLVEVNEGFTRITGYDGAAAVDRS---TVTLGIWVDLQEREQLLKLSR----DGYVRSHIRRKDGQVRVCEISSRPLLI--AGEDCMLTIARDITERQQ
MQQKLQLAATVFESTAEGVLITDTRQRINAVNRAFSEITGYSENEAIGQTPRLLASGLHDSAFYAAMWYQLTAEGHWQGEISNRRKNGEIYPSWLTISAV
RNRDQFITHFVAVFADISSLKHAQARLDYQAHHDPLTGLPNRTLFESRLQAALIHSLESNSLGAVLFLDLDRFKHINDSLGHPVGDLLLQGIAQRLKEHL
RDIDTVARLGGDEFIILLPGLQNSDAEIIATKLLACFTAPFQAGEHEFFISASIGSCLFPTDGEDVATVVKNADAAMYRSKAKGRNRVESYTRDLTSQAS
ERIALEHELRRAIERNELSLSYQPKVSLITHKLVGAEALLRWTHPIFGEVHPEQFITLAEENGMILQIGDWVLEQACQQMCEWNKTYKPFGPLSVNLAGA
QLRQPNLLTRIEQLLAKNQLKPGYLQLEITENFIMSQAEEALKVLHKLKKLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFIRSLPDDPHDAAIARA
IIALGRSMQLTIIAEGVETAEQRQFLTDEGCEQIQGYLISPPLHPDEFSARF--------
>tr|A0A085VHF4|A0A085VHF4_PSESX Diguanylate phosphodiesterase OS=Pseudomonas syringae GN=IV01_14280 PE=4 SV=1
--------------------------------------------------------------------------------EKFAKFHSSPDGMVITRQSD
GLLVEMNDGFTRLTGYDDHLMKDES---TLTLGIWANLHERERLLELSR----DGFVRSHIRHKNGQIRLCEISSRPLLI--GGEDCMLTIARDITERHQ
MQEKLQLAATVFESTAEGVLITDTRQRITAVNRAFSEITGYSEQEAMAGTPRLLASGLHDSAFYAAMWYQLTAEGHWQGEISNRRKNGEVYPSWLTISAV
RNRDQFITHFVAVFADISSLKHAQARLDYQAHHDPLTGLPNRTLFESRLQAALNHSLESNSLGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAQRLKENL
RDIDTVARLGGDEFIILLPGLLHNDAESIANKLLASFAAPFQAGEHEFFISSSIGSCLFPTDGTDVATVVKNADAAMYRSKAKGRNRVESYTRDLTSQAS
ARIALEHELRRAMERNEFSLSYQPKISLLNQQVVGAEALIRWTHPTLGEVPPEHFIALAEENGMILQIGDWVLEHACMQMYEWNKIYQPFGALSVNLAGA
QLRQPKLLARIEQLLADYQLAPECLQLEITENFIMSQAEEALAVLYRLKRLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFVRGLPDDTHDAAIVRA
IIALGRSMQLTVIAEGVETLEQQQFLADEGCEQIQGYIVSLPQRPEEFSAKF--------
>tr|A5V028|A5V028_ROSS1 Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Roseiflexus sp. (strain R
------------------------------------------------------------------------ALALRQQTITLHAILESLSDAVVVIDRE
GNLVHANPVAHTLFGDRLLDVTPQATAPAGVPCATDQLP-LAI----ALRGVEVDSSEFLLSVDPDAVRRIRATARPLRDSNGDIIGSVAIFRDITVSFQ
MAQALRASEERYQATGDGVWEWELRTGIMTFSRRWKEMLGFQDQEI-GNLPSEWFNRVHPDDRDGLDVRLTAYITSFEHEYRILHRDGAYRWMRCRGIAI
WDADGNAAHIVGSQTDITDRKLAEQRLWYNAFHDSLTGLANRARFMDRLGHVIARARRSSPPYAVLILDLDRFKLINDSLGHLVGDQLLIAIARRLEQSL
RPGDTLAHLGGDEFAVLLEDLSEHAAVNVAERILHLFEEPFHLNEHEVFSSASIGIALSDLRYHSPSDMLRDADTAMHHAKMEGRARYAVFHPTMHDRAR
PRLQIEIDLRRGIERNEFFVVYQPIVELSTQRTVGFEALLRWRHPQRGIVTPAEFIAIAEETGLIVPIGQMVLREACRQLSAWKQRPERTLAMNINLSPR
QIADPDLVHRTAALIDEYRLDADALRLEITETAIIEHGDAAGRVLQQLRALGVQICIDDFGTGYSSLSYLHRFPIATIKIDRSFVSQIHRSHENTEIVRS
IISLARSLGMAVIAEGTETEEQLLRLRSMSCAYGQGWLFAHALEPAEATAMLDRE-----
>tr|A7NP64|A7NP64_ROSCS Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Roseiflexus castenholzii 
------------------------------------------------------------------------AAALRQQMLTQQSILDSIGDAIVVIDGD
GRLLHVNPAARDLFGDRVVDLTPQATARVDTSCPPDTLP-LAV----ALRGEALDGAEFLLSPDS-AKRWLSVTARPLRDLDGAISGAVAVFRDVTITRQ
AAEALRASEERYQAANDGLWDWDLTTGKIYFSQRWKASIGFQDHEI-GNDPSEWFDRVHPDDREGLEVRLVAHISGFEYEYRMRHHDGAYRWMSCRGIAV
WNAGGQAVRIVGSQTDINARKLVEQRLLHEALHDSLTGLANRSCFMDRLEHVVARTRRGSSPFAVLFLDLDRFKLINDSLGHVVGDQLLIAIARRLERCL
RPGDTLARLGGDEFAVLLEDLSEQAALTVAERILRLLEEPFHLAGHEVFSSASIGIALNDTRYHSPADVLRDADTAMYHAKMEGRSRYAVFHSAMHDRAR
HRLQIETDLRRGVERNEFFVVYQPIVELNTQQTVGFEALLRWRHPHRGIISPTEFIDVAEETGLIVPIGQMVLREACRQLSEWRQRPARTITMHINLSPR
QIADPHLVDDTIALLNAYHLDAGSLHLEITETAIIEHGDIASRALMHLRSLGAQICIDDFGAGYSSLSYLHRFPIGTIKIDRSFISQIHHSHENAEIVRT
IIALAHSLGMTVIAEGAETEEQLARLRSMSCPYGQGWLFARALEPAAATALLDAA-----
>tr|A7NNP6|A7NNP6_ROSCS Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Roseiflexus castenholzii 
------------------------------------------------------------------------EASLRQQTNLLLAVLDSMGDAVVVTDAA
GRLILYNSAAVHMLGDRLMSLLPSAPDTARSSLTPRDLP-FAR----ALRGESVNAAEVHLAGDAGAEQWLSITARPLRDTEG-LSGSVAIVRDVTEAKR
AEAALRASEERYQGANDGLWDWDLVNDRIYFASRWKAMLGYGDDEI-GTSPDEWFSRVHPDDRERVELRLLAHIASFELEYRILHRDGAYRWMLCRGIAV
WDASGRATRMVGSQTDITDRKRAEERLEYGILHDTLTGLPNRTLFMDRLSLALRRSQRERSLFAVLFLDLDRFKTINDSLGHAAGDELLVVVARRLEGVL
RPGDTVARLGGDEFAVMLDRLDAEDAEWIAERIQQALRAPLTIGGRTVYTTASIGLVLSNQGYERAEEIARDADTAMYQAKMGQRARYVVFDPDMRRKAL
SHFQLENDLRSAIEHGELCVYYQPIVALTSGRIVAVEALARWQHPQYGLIAPDQFIALAEEVGLINAIGQWVLQEACRQLRVWRTYPHYDMWVNVNLSAH
QLAQPDLVAQVADTIARNDVPARALKLEITENTFITHRDVAAAQLNDLRSLGVGVCIDDFGTGYSSLSYLSQFPVDTLKIDRVFINRLGAAREHREIVKA
IITLAHSLGMTVVAEGVETLDQANELRALRCEYAQGWLFGCTAPPEQMEQMLAAH-----
>tr|A5UVR9|A5UVR9_ROSS1 Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Roseiflexus sp. (strain R
------------------------------------------------------------------------EEALRQQTNLLRAILDSMGDAVVVTDTD
GHLIHHNPAAVQILGDRLASLLPGSSSAARSWLTPHDLP-FAR----ALHGESVDAAEVRLATDCHPEQWLSITARPLRDTDG-LSGSVAIVRDVTEAKR
AEEALRASEERYQGANDGLWDWDLVSGKIYFAPRWKAMLGYDDTDI-GTSPDEWFRRLHPDDRERVEWRLLAHITSFELEYRILHRDGNYRWMLCRGMAV
WDEHGRATRMVGSQTDITGRKQAEEQLAYGALHDALTGLPNRTLFMDRLSLALKRAQREKHLFAVLFLDLDRFKTINDSLGHAAGDELLIAVARRLESVL
RPGDTVARLGGDEFAVMLDRLNAEEAEWIVERIHQALQAPLSVRGHTVYTTASIGLALGNEGYERPEELARDADTAMYQAKMQRRARHVVFDPDMRRKAV
SHFQLENDLRSAIERNELRVHYQPIVALNGRRVVAFEALARWQHPQHGLISPDQFIPLSEEIGLINTIGHWVLRDVCHQVREWRRRPRHDMWVNVNLSAH
QLAQPDLVAQIAHAIADAGIPPNAIKIELTENTFVTHREIAIAQLNELRSLGVGVCIDDFGAGYSSLGYLSQFPVDTLKIDRVFIARLGMMREHYEIVKA
IITLAHSLGMTVVAEGVETEEQATMLSALRCEYAQGWLFGRALPADQVEAFLDSR-----
>tr|F4G8H7|F4G8H7_ALIDK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K
-------------------------------------------------------------------------------------LAENTVAGIYMLDES
GRIIYANEQLAQILGYGRAQLSDRFPMEL--FPPPAR--------------QHSARHERSALRADGSKIEIEIFGSAMTF-QGR-PAVIGLVMDITERKR
AEMSARRAALVYQHTSEAMVVTDAQGVVQDINPAFTAITGYEAADILGRRMNVLSSGRQDRAFYEALWTSLRETGSWSGDMRNRRKNGEEFVERLTISTS
YNEDGSVHSHIGLFADVTEARRREASIWRQAHYDHLTQLPNRQMFQQDLQRSMDSARASDLPLALVFLDLDYFKEVNDTFGHDMGDELLRQVARRLQSCV
RSSDQVARLGGDEFTLILRDLKREDAPAICRKVLHAVAQPYELSGSTVHVSVSAGVTFYPRDGDDGVTLLKHADLAMYAAKEQGRNQFCEFAPTMEQEAQ
NRRLLLRDLQQGLDEGEFALHYQPIVEMRSGRTVKAEALLRWNQPVRGMVSPADFIALAEESGLIVPLGDWVMREAACQLAQWREEIAPAFRLSVNVSPV
QLNSSGVQAWV-AHLQDLSLPGSALVAEITERVLLEADKDTDARLQTLQGAGIQLALDDFGTGYSSLSYLKRFDIDYIKIDRSFVSLLSQGNEDATLCQA
IIAMAHQLGICVVAEGVETREQHDILQRAGCDYGQGYWYGRPMPAQELTERLRAQ-----
>tr|A0A0C1YRY0|A0A0C1YRY0_9BURK Uncharacterized protein OS=Herbaspirillum sp. TSA66 GN=TSA66_02975 PE=4 SV=1
-------------------------------------------------------------------------------------LAENSMVGVYVVQD-
GHFRFVNAKMASMFGYERDAMLESVGVYL--VPEGDHNL-VES----NVRKAQSVRYERRARRKDDSVFDVEVFGSVMRL-DGK-PATIGMMLDITERKQ
AEATTRMATMVYQNTGEAMTITDANGLVIDINPAFTRITGYQREEVVGQRISILRSGRQDREFYEAMWRAISSTGYWQGEIWNRRKNGDVYAEWLTINTV
YHPNGTVFRRIALFSDITHKKRTDDLVWRQANFDSLTGLPNRLMFRDRLEQEIRKSHRAALPMALIFIDLDRFKEVNDTLGHAVGDKLLQQAAQRLSRCV
RESDTVARLGGDEFTIILGELNQNNVERIVQDVLKSMAEPFVLGDEIAYVSASLGITFYPDDATEIEDLLKNADQAMYAAKNLGRNRFHYFTPCMQKEAQ
ARRRLISDLRLALADRQFRVQYQPIVDLSTGAISKAEALIRWQHPTRGMVSPAEFIPIAEETGLIVEIGDWVFREVAWQLSRWRERY-PQLVVSLNTSPV
QYRNSGHHGWF-RYLHDMGVPASAISVEITEGLLLDTSTAITNQILRFREAGAGVALDDFGTGYSSMSYLSKLDIDYLKIDRSFILDLAPESESVALYEA
MIVMAHKLGIKVIAEGVETEEQCRILKAVGCDYAQGYLFSRPVLPEEFEALLRDG-----
>tr|J0B6W6|J0B6W6_ALCFA PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Alcaligenes faecalis subsp. faecalis NCIB 8687 GN=QWA_12232 
-------------------------------------------------------------------------------------VSHNPLLGIYVSRD-
GRFDFVNKKLAETLGYSRAQLRQEFTVDI--FLSPRFPS-LTH----TVPDGSSLRYETRALRHDGKSIDVEICAIPIRL-DGR-TAMVAVVQDITTRVR
NEVTGRLAAVVYENTCEAIVVTDRFGHVVDANPAFSRITGYELDEVRGRSLSLLNSGRQDREFYRKMWREISETGRWQGDIWNRRKNGEDFAERLTISTA
WNPDGTVYRHIGLFTDITSHKKREAQMWRQAHYDHLTGLPNRQMFQDRLQQAREQSRRTGLPFALIFMDLDFFKDVNDSLGHEKGDVLLQEVAQRLQRCV
RVTDTVARIGGDEFTVILSDISDSIVERTCRCLLDTIEEPFQLGKNSVSVSASVGITLFPEDGDDAGQLLKNADMAMYAAKACGRNQYCRFLPAMSEAVE
ARLRFSQDLQKALSEKQFQLYYQPIVDMRTGQVTRAEALIRWEHPQLGLVPPSEFIPFSEDSGLIVLIGEWVFETAAQAAVRLRHELDPSFRVSLNVSPA
QFKLNGAREWV-EYLQTQGIPGDALVVEITERLLLDDQGQALQQLRSLREYGMSVALDDFGTGYSSLSHLKRFSINVLKIDQCYIRNLALSSEYLVLTQA
MIVMAQKLGLRVVAEGVTSHEQLDLLNHAGCDYMQGYLCSTPIPADEFVDWCKTW-----
>tr|W8X0G0|W8X0G0_CASDE Uncharacterized protein OS=Castellaniella defragrans 65Phen GN=BN940_15571 PE=4 SV=1
-------------------------------------------------------------------------------------LASNSIVGIFLVEN-
ERFTFVSSKMAEIFGYEPREMVDAMTLLI--VVPRERFL-MAE----SIKADGTLRFERHGRRKDGSEIDIEVFSSTVRV-GEQ-VSVIGIVQDITERKQ
AESSAQLAAIAYENSSEAIAITDSAGVVIDVNPAYSRMTGFWPDEIAGELLPLLRPGRHNRDFYDEMWHAINTQGRWEGEYWSQRKSGEDYAERVVMDTA
WNHDGSVNCRVAMLSDVTQKKQIEAQIWNQAHHDPLTGLPNRQYFNERLQAAVQSADQSGQPLALLFLDLDLFKEINDSMGHATGDRLLVEVARRLQSCA
PETSFVARLGGDEFVVILNDTADARIDALCRAILDRITEPYRLGGDPLRISASLGVALYPQDAEDAESLMRHVDMAMYVAKDSGRNCFHYFDRSMRERAR
MQRDLMYALPQAIQDSQFFLLFQPIHSFRTGRIVLAEVLLRWRHPEFGVIVPADFIPFAEERLLIRPLGDWVFRESIRQLARWREALAPDLRLTINVSPG
QLGLEDLDVVF-GLFDALDLPPDCLVLELSEQMLMTGDLQAQDRLRRLHEAGLRFSVGAVSIGMPALLAVNELPFETLKLERATTERLLDGEHAPMVSEA
IIALAHRLGLRVTAEGIVSQAQYELLRDAGCDEGQGYWFDEPLDQAAFEQRLRRQ-----
>tr|G2IZ17|G2IZ17_PSEUL Diguanylate cyclase/phosphodiesterase with PAS sensor(S) OS=Pseudogulbenkiania sp. (strain NH8B) GN=NH8B_0938 PE=4 SV=1
------------------------------------------------------------------------E-------NKYREL---NLDGIVISSLD
GQVIDANPAFLNLMCYSLDQLK---LQ-FWSLIAPESEG-MER----FNLD-------ASYINRFGNVVPVSVKTVAMRDSFGRINAVWRMVRDISEKRV
AEERMQLAAKVFENTVEGIMITDADKRIRSVNRAFSQITGFGQQEVLGQKPDMLSSGRHDETFYEAMWSAINEHGSWQGELWNRRKNGEVYPEWLAISAV
RNAVGEITHYVAIFSDLSERKAADERIQFLAHFDVLTGLPNRAHIQDRVELAIQNATRDNERLALLLLDLDRFKTINESLGHSAGDALLQVLAERIRSTL
LTGEVVARQGGDEFIVLLPLIADGSAALAAERIREVLEPPVELFNHSISITPSIGISVFPDDGRDFETLVRNADAAMYHAKSAGRNSYKFYTADLNARAR
EILEIESQLRYALDRDEFVLHYQPQVDLKTGEIIGAEALIRWQHPELGLLGPVRFIEVAEERGFIVQIGNWVIQEACRQLAQWRRQGLPRISLAVNLSTL
QFRQQDLAVHLQRALSAHGLVGSDLDVEVTESVIMDDVETTIHTIDRIKSMGLQLSIDDFGTGYSSLSYLKRFKADKLKIDRSFVRDIPMDADDSAIARA
IINMAKNLNMTVIAEGVETIEQWKFLDREGCHAAQGYLLAKPVPAKEFEKLLEKG-----
>tr|A0A0C1CC63|A0A0C1CC63_9NEIS Diguanylate cyclase OS=Chromobacterium piscinae GN=QR66_05485 PE=4 SV=1
------------------------------------------------------------------------E-------NKYREL---NLDGIVISSLD
GQVIDANPAFLNLMCYSLDQLK---QQ-FWGLVAEESEA-LER----FNLD-------ATYLNRFDNQVPVSVKTVAMRDAFGRINAVWRMVRDISEKRA
AEERVQLAAKVFENTVEGIMITDADKRIRSVNRAFTEITGYTQHEVLGQKTSILSSGRHDEPFYEQMWQSISEQGSWQGELWNRRKNGEVYPEWLAINAV
RNSLGEITHYVAIFSDLTERKAADDRIQFLAHFDVLTSLPNRVHMQDRVELAIHNAVRDNQRLALLLLDLDRFKTVNESLGHSAGDTLLQVAADRIRSVL
APGEMLARQGGDEFIILLPLISDGEAALAAERVREVFASPIELHNHVITITPSIGISVYPDDGRDYETLVRNADAAMYHAKSSGRNSYKFYTADLNARAR
EILAIESQLRFALERDEFVLHYQPQVDMKTGCIIGAEALIRWNHPSLGLLGPVRFIQVAEERGFIVQIGNWVIAEATRQMVAWRQAGLPEVTLAINLSAL
QFRQPDLAEQVQQALLSHDLPGHALDIEVTESVIMEDAQATIQAIDTMKSMGLRLSIDDFGTGYSSLSYLKRFKADKLKIDRSFVRDIPQDADDSAIARA
IINMAKNLNMQVVAEGVETMEQWQFLEQEGCDFVQGYLIAKPLPAEEFAALLTQG-----
>tr|L9PSF6|L9PSF6_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Janthinobacterium sp. HH01 GN=Jab_1c24210 PE=4 SV=1
------------------------------------------------------------------------QSYE----VEYRILDAAAENGQPQP-HD
G---EGNAPWVDGIISDISQRK---HNEIEALLAEQSAI-LDN----VMFGGDYFNEERHYRRKDGSLFWCMVSGYALDDKRANEGSIWV-YADITARKE
AEEKLRLSATVIEHIADGVVVLDAAGIIVAVNPAFTQITGYTEAEALGKDRTLTRSGRHDAEFYAQMWQEQVDKGFWRGEIWNQRKNGELYLEWLTVSAV
RDSRGETTHYVGVFSDITKVKESQEKLDHLAHHDPLTALPNRLLFHDRLQHALQRAARDGEQLALLFIDLDRFKNVNDTLGHHIGDELLKQVAKALHERL
REGDTLARLGGDEFIVLLENIENFGASQVAEKLVQMFEQPFMVAGHELFVTCSVGISLFPDDAVDLNMLIRNADVAMYQAKARGRNGYSFYTPSMTGEGV
ERLRLETFLRRSIEKDEIFLNYQPQVEIDTGRLIGVEALVRWNHPELGLVPPIRFIPLAEDTGFINQLGKWVLEEACRQMIRWQAAGLNVPKMAVNLSAK
QFERGSIVNMVADILRETGLEPQRLQLEVTESVIMNTGDAM-VFINDLHSIGVGLAIDDFGTGYSSLAYLKQLPVQTLKIDRSFIKDISTDVNDEAIAIA
IIQLGKSMNLSVIAEGVETEEQAAFLLRHGCHLAQGYFYSKPVAADDMLTRWRTS-----
>tr|G8QH66|G8QH66_AZOSU PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Azospira oryzae (strain ATCC BAA-33 / DSM 13638 / PS)
------------------------------------------------------------------------L----------------D--------AQ
GRYVGCNEAFLTYLGKERH------------------EL-LGK----SVYD-----SQACY--ADGSKHDVIYNKATFMDAEGRVAGLVGVMVDITERKR
QEEELRLAAKVFDTSNEAFLVTDADNNIRSVNRAFCETTGYSAEEVLGRNPRLLSSGHHDKTFYRQMWEALNSQGYWQGEIYDRRKSGEIYPKWTRINVV
KDDQGRVVNHVAVFSDISDRKALEERLQFLAQHDHLTGLPNRNLLRLRLEQAVESAAGGINPVALLLLDLDHFKTINDSLGHHAGDQLLRTVVKRLKNIL
RESSTLCRQGGDEFLIVLPQAQDARVSRAAETVLAALATPFEVDGHPLSITGSIGISLAPDDGSDFDTLLKKADTALVHAKQSGRNAYRFFTEAMNVSTL
ERLTLQQRLHQALERQELVLYYQPQLDLASGRVVGVEALLRWRTPE-GLVPPGKFIPLAEETGLIVPMGAWVIQEACRQARTWLDAGLPPMTMAVNLSAL
QFHRDNLLITVGDALSAASLPAASLELELTESILIQDAEATLATLKAMNAMGVLLSIDDFGTGYSSLAYLKRFTVDKLKIDQSFVRDITSDGDSAAIVRA
VVQMASSLKLKTIAEGVETESQAAALRATGCDEVQGYLYARPMPAAECEAYLRGK-----
>tr|K2JGM1|K2JGM1_9GAMM Uncharacterized protein OS=Gallaecimonas xiamenensis 3-C-1 GN=B3C1_09877 PE=4 SV=1
-----------------------------------------------------------------------------------------DLVS-ITRLDD
GVLVNVNENWVKRIGWSKEEVLGRTTLEVWSNPSDRQQL-VGQ----VK--NLLRNVRLCFQDRWGETVEAEASGCVFEE--NDVPYLLLSFRDIGERLR
KEKDLRLLAQVVEVSLDGVMITDASQHILTVNSAFTTITGFAPEDVIGQTPKVLSSGYQDASFYKTMWQQIAAQGFWKGEIWNKRKSGEVYPQWLSIRAM
EDDYGQVQHYVAVFSDISEHKAAEARIAFLAYHDPLTGLPNRTLLVDRAEQALIQAKRGGDRLAIIYLDLDRFKSVNDSLGHDIGDTLLKEVVKRIKPLC
REGDTLSRQGGDEFLLLIPKLVANQVELIVERILAAMSEPFVIGGHRLWISTSIGVSLYPEDGDNVAQLLRQADTALYHAKDSGRSTYSFFNKDMDRDLN
ERLQLESALKDAIGTPQLTLHYQPQFDVASGDIVGVEALMRWHSPVLGDVSPSKFIPLAEDTGLIMPLGAWCLEEACRQLAQWRKAGFQG-LMAVNISVR
QLVRPDFFDLLESVLAGTDIPAHRLELELTESLMMDNVDASLEVVRRLKALQLTLSIDDFGTGYSSLSYLKQFSVDSLKIDQSFIRGLSDAQQSRPLVRA
IVQMAHSLELRVIAEGVETSEQLAILRQEGVDVAQGYFLGRPEPAKVISGLLAEQ-----
>tr|F9UE48|F9UE48_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_3150 PE=4 SV=1
------------------------------------------------------------------------E-------EKYRFLLEYSYDIIYLFSTD
GSFIFVSPSWSRLMGYSIDETLATHFSV---YVHPEDLH-ICN----AAFSEMRRDIEYRVRHGDGTWRWHSSSAMPFRDENGVIVGFQGIARDFTEQKE
TREQLRIAAIAFEA-QEGMVVTDADGVILQVNGTFTRITGYSAVEAIGQTTRLLKSGRHEPEFYVAMWASILETGSWQGEIWNRRKSGEIYPQWLTISAV
PGPGGQITHYVGTMTDITQRKADEEEIRELAFFDPLTRLPNRRLLLDRLQQALSSGRREGHCGALFYIDLDDFKTLNDTLGHDQGDRLLQLVARRLSTRI
RESDTLARLGGDEFVVMAEHLSASQAEALGNALLGVLRQPYDLGGQTHYSAASIGVTLFEPHPMRVEELMKQGDLAMYRAKAAGRNTIRFFDPSMQSEVS
ARATLEAQLRCGLRDERFLLHYQIQVDR-EGAVIGAECLLRWRDPQGRLVPPVAFIPLAEQSGLILPIGHWVLQTACGQLAAWSAQETAQLTLAVNISAR
QFRRTDFVDQVLTCIRDTGADPSRLKLEITESLLLDDVEDTVAKMIALKARGVGFALDDFGTGYSSLSYLKRLPFDQLKIDRSFVLDVLTDTNAAAIART
IIALGRTLELAVIAEGVETEEQRDWLAAHGCHAYQGYFFGRPEPLDSLSLDTPKA-----
>tr|Q2BN03|Q2BN03_NEPCE Sensory box sensor/GGDEF/EAL domain protein OS=Neptuniibacter caesariensis GN=MED92_03573 PE=4 SV=1
-------------------------------------------------------------------------------------LLDNFPFLIWLKNTD
GEFLSVNKAFAEACGKKDPLEVEGLTDFV--WPVDLAND-YRL----DDLKQG--KVVEEKVESDGERTWIETFKSPVLHNNEV-IGTVGFARDVSDRKH
AAERQRKAEAIFNSASEAILLSDAYSKVKMINPAFTKITGYEESEIIGQNASMLSSGQHDKEFYRTMYAALETEGLWQGEVHNRKKNGELYVQWQTVVAL
KDGNGNVDEYLAIFSDITEKKEAEEEIKYRANYDQLTGLPNRTLLHELLRQELQHSRRESKKCAVMFLDLDHFKRINDTLGHAVGDLLLQTVSELLQETI
RESDVVARLGGDEFIVILSDVDNTDISTVAEKIVSVLDTPLSIDDHEIRTCTSIGIAVYPDDAFEEGELLSHADMAMYKAKESGRGQYRFFNADMAKEIR
SSRSIEIELRNAIENEDLAVAFQPIVSMGDKAILGFESLMRWPESANHNTSIEQSIRNAEEFGLIQPLFEVVFEKAAREFSRLPLRDNPQLYFSINVSSH
QIPERLSLEWIEERLRYYGLANENLVLELTEGIFLSDSPENLRWFKRARDKGIRIALDDFGTGYSSLAYLKRFTVDFLKIDRSFIADLDELGADYSLVKS
VLALSDAFGLKVIAEGVETEKQASILAELGCKTAQGYYYGKPKIVTGSTSSHHKG-----
>tr|S6JEU4|S6JEU4_9PSED Putative sensory box-containing diguanylate cyclase OS=Pseudomonas sp. CF161 GN=CF161_01776 PE=4 SV=1
-----------------------------------------------------------------------ANKALSKSEARLALALKASELGLWDWNLQ
TDEVHH-TQVKELFGLEPDYVTAML-SHLKPRLHPEDLPLLRRALVEH-LKGEDYQVEYRVRHGAGHWVWIEDRGRAVRSASGRVTRMVGTRRDISTSKE
LEEQRNLAATVFEAASEGIVILDPNYALIAINQAFSRVTGYQIEDMLGRNVVELPCSRDARRHYPAIRQALEQHGSWQGELVEARKNGELYPQWLQLSMV
RDKRGQVSHIVGFFADLSARRESEERMRYLTHYDELTGLANRSLFRERLRDAHLRVRQGGRSLALVHINLDRFKLLNDSLGHDVADQLLQKMARRLVNAL
PEADTIARLSGDEFAVLFDAYGSSSLTRVATRLLSKLRLPLTVDGHELVVSASMGISLLPDSAREISALISQSNMAMQYAKHLGGNNFQFYTESLQASTL
ERLQLENQLRKAIDDQQLKVFYQPKLCLASGHLNAAEALVRWDHPTMGRVPPGDFIGLAEETGLIGPIGEFVLRQACWQACEWQRQGLAPIRVSVNLSVY
QLRQGKLVSLVRQVLEETGLEPQYLELELTESQLLDSVEHIISTFQQLRGLGVKLAIDDFGTGYSSLSYLKRIPVDYVKIDQAFIRGLTEGSADAAITRA
IIAMAHGLSLKVVAEGVEHPGQLAFLKAEQCDEVQGYLISRPVEAEGLAALLRADA----
>tr|A0A0D9A7K7|A0A0D9A7K7_9PSED Diguanylate cyclase OS=Pseudomonas sp. ES3-33 GN=UB23_18980 PE=4 SV=1
-----------------------------------------------------------------------ANQALSKSEARLALALKASELGLWDWNLQ
TDEVHH-TQLQELFGLEPELVTAML-RHLKPRLHPEDLPALKRALVEH-LKGEDYQIEYRVRHGDGHWVWIEDRGRAVRGENGRVVRMVGTRRNISVSKH
HETQQQLAATVFEAASEGIVIFDPNYALIAANQAFCRVTGYEIEDLLGLSVVDLPCSRDARRHYSAIRQALEQHGSWQGELVETRKNGELYPQWLQLSAV
RDNRGNVSHLVGFFADLSARRESEERMRFLTHYDELTGLANRSLFRERLREAHQRMRQGGRSLALLHINLDRFKLLNESLGHDIADELLQKIARRLVSAL
PEAETIARLSGDEFAVLFDSYANSSLARVATRVSAKLRLPLNIDGHELVVSASMGISMLPDNAREISALVSQSNMAMQHAKHLGGNNFQFYTESLQASTL
ERLQLENQLRKAIDEKQLKVFYQPKLCLATGRLNAAEALVRWDHPDRGRVSPAEFIGLAEETGLIGPIGEFVLRQACWQACEWQRQGLEPIRVSVNLSVY
QLRQGKLVSLVRQVLEETGLAPQYLELELTESQLLDSVEHIISTFQQLRDLGVKLAIDDFGTGYSSLSYLKRIPVDYVKIDQTFIRGLGEGQMDAAITRA
IIAMAHGLSLKVVAEGVERPEQLEFLRGEHCDEVQGYLISKPVEAQQLASLLQLQG----
>tr|U8M6W2|U8M6W2_PSEAI Uncharacterized protein OS=Pseudomonas aeruginosa BL04 GN=Q058_04468 PE=4 SV=1
-----------------------------------------------------------------------TSQALSQSEARLAMALEASELGLWDWNLE
SGRVQH-SYLEAVFSDAGDGPEDYR--RLIESIHPGDLPRIRRALAEH-LKGELYRVEYRVRDREGGWRWLEDRGRAMRDPRGRVTRMLGTRSDISARKR
LEEQQQLAATVFEAASESIVILDPAYNLLAVNQAFSRITGYRREDVVGRNASLLVNTPEAQRHYRQIRAELRQHGQWQGELVDTRKNGDPYPQWLQLNLL
RDGNGEATHIVGFFTDLSARRDVEERLRHLLHYDELTGLANRRLFRERLHEAAQRARQEEGGLALLLIDLDRFKLLNDSLGHEVADQLLREMAQRLRRTA
PEANTLARLAGDEFAILLDGGTGAALSRLAERLLVQLRQPVSVLGHELILGASLGISLFSEQAREISVLMSQANLAMQHAKQLGGNTFQFFRDNLQDSTL
ERLRLETRLRKAVEEGQLDVHYQPKLCLASGRPDSVEALVRWHHPEEGMIPPSTFIGLAEECGLIGEIGEFVLRRACLQAAEWSQRGL-NLRVSVNLSVH
QLRQGDLLDVVRSALADSGLPAAQLELELTESQWLDALDSVLATFRQLREMGVKLSVDDFGTGYSSLSYLKRLPLDYLKIDQSFVRDLTQNSEDAAIIRA
IIAMAHSLDLKVVAEGVETIEQRDFLVAQRCDELQGYLIGRPLPAHALEEGLRQAR----
>tr|A0A0D9AV01|A0A0D9AV01_PSEST Diguanylate cyclase OS=Pseudomonas stutzeri GN=UF78_01085 PE=4 SV=1
----------------------------------------------------------------------------RESEARLTLALEASELGLWDWNIE
QGEVHH-SRMEVVFGIGQNDSARRI-DPQRPEIHPEDLPRVRKEIIAH-FKGELYRVQYRALRPDGSCLWMEDRGRVIRDAKGRAVRMIGTRRDVSETHR
QAEQQRLAAAVFEAASEGMAIMDAEFRVLAVNNACCALSGYTREELIGRSVARLASSEDSRQQYASIRESLEQDGCWQGELIETRKNGEVYPQWAQLQVV
RDSRGRISNVVAFVSDIGVRRQVEERLRYLTHFDELTGLANRGMLKARLHAACERARNSNRGLAVLYIDLDRFKLLNQSLGHEAADQLLREVSRRLSHTF
SDADTIARLSGDEFVVVLEGYGSSTLAHSGSRLLSRISKPVLVDGQELVVSASVGVSLMPDNAREATSLLLQANMAMQHAKHLGGNTLQFFTERLQTSSL
ENLQLENQLRRALDEGQLEVFYQPRLDVVDDRLDAAEALVRWRHPQQGLMAPGSFIPLAEETGLIIPLGEFVLREACRQARQWQLDGLAAIRVSVNLSVK
QLRQGNLVSLVRQVLEETGLPADRLELELTESQLLDDVDNAVSISHQLRALGVKLAIDDFGTGYSSLSYLKRFPVDFVKIDRSFISELDQFGEDSAIVRA
IIAMVHSLELKVVAEGVETQEQMDFLKAHQCDEVQGYLISRPVPAGEFVKLLA-------
>tr|I6ZAX1|I6ZAX1_PSEST Uncharacterized protein OS=Pseudomonas stutzeri DSM 10701 GN=PSJM300_01190 PE=4 SV=1
-----------------------------------------------------------------------VVEALGQSEARLSLALEASELGLWDWDLR
NDEVHH-SGLSIAIDQSGL-PAGQA-DYHWHSLDADDVPRVRNTMVAH-LKGETYKVEYRVQRDDGSSLWIEDRGRVIRDENGRALRMIGTRRDISEARR
QAEQQRLAAVVFEAASEGVAIMDAGYRLLAVNDACCELSGYSREELVGHSVARLASSAESKQLYASMREALRRDGGWQGELIEARKNGENYPQWVQLRAV
RDAHGAISNVVAFISDLTLRRQVEERLRYLSRYDELTGLANRSLFKERLHDACQRARGANGHLAVLFIDLDRFKVLNESLGHEAADQLLKEVSRRLVYSL
AGADTIARLSGDEFVVLLEGYGSSSLAHVGSRLLGRIRKPMDIAGQELVVSASIGISLLPDNTREPATLLAQANMAMQHAKHLGGNTLQFFTERLQASGL
ENLKLENQLRQALEKGQLEVFYQPRLSLQADRLDAAEALVRWHHPEQGLLTPAYFIALAEETGLIVALGEFVLRQACRQARQWQLDGLASIRVSVNLSAK
QLRQGNLVSLVRQTLEETGLPAAMLELELTESQLLDDVENAINICTQLRALGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDKTFISELEQSKEDTAIIRA
IIAMVHGLELEVVAEGVETQSQMDFLKDQRCDEIQGYLISRPVPAAQFAELLG-------
>tr|U3HSE4|U3HSE4_PSEST Diguanylate cyclase OS=Pseudomonas stutzeri MF28 GN=L686_02225 PE=4 SV=1
----------------------------------------------------------------------------RESEARLTLALEASELGMWDWDMA
NDEVHH-SRMDVIFGVGRSDRLRLA-DQQRPEVHPEDGERVRQDMIDH-LKGDIYSVQYRAMLLDGTSIWIEDRGRVIRDANGRALRMIGTRRDISQSHR
QAEQLRLAATVFEAASEGMAIMDPEFRLLAVNQACCKLSGFTREELIGRSVALLASSEDSRQQYATIRESLVQHGSWQGELIETRKNGEVYPQWAQMRVV
RDAHGNVTNVVAFVSDLSIRRQAEERLRYLTYFDELTGLANRTLLKERLHSACERSRSSNRGLAVLYIDLDRFKILNESLGHEAADQLLHEVSRRLSHTL
SDADTIARLSGDEFVAVLDGYGSASLAHTASRLLARISKPIQIGDQELVVRASIGASLMPDNSREAASLLLQANMAMQHAKHLGGNTLQFFTERLQASSL
ENLKLENQLRRGLEEGQLEVFYQPRLNVADDRLDAAEALVRWRHPQKGLIAPGFFIPLAEETGLIIALGEFVLRQACRQARQWQLDGLAEIRVSVNLSVK
QLRQGNFVSLVRQILDETGLPADRLELELTESQLLDDIDNAITISRQLRALGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDRSFICELDQVGEDSAIVRA
IIAMVHSLELKVVAEGVETQAQADFLKAHGCDEMQGYLISRPVPAEEFVELLM-------
>tr|A0A023WXI7|A0A023WXI7_PSEST Diguanylate cyclase OS=Pseudomonas stutzeri GN=UIB01_20925 PE=4 SV=1
-----------------------------------------------------------------------VAEELGESEARLNLALDASGLGLWDWDLQ
HNRVHH-SRLEVVFGIGLQKRRAED-GAQLPDIHPSDLEAVRATLIAH-LKGELYGVEFRAVRADGSEMFIEDRGRVIRDPSGRALRMIGTRRDVSDVRR
QAEQQRLAATVFEAASEGMVIMDANYRVLAVNDACCELSGYGREELLGRSIARIAGSPESQRQYQAMREALERNGHWQGELIETRKSGEVYPQWVQLREV
RAADDSVTHVVAFISDLSVRRKIEERLRYLTHYDDLTGLANRGLFKERLHDACQRVRRNGRNLAVLYIDLDRFKLLNESLGHEAADALLREVSRRLSMTL
TEADTIARLSGDEFVVLLDAYGSSSLAHLGSRLLQRIRKPMTIGEQELVISASIGVSLLPDNSRDADALLRQANSAMQQAKHLGGNTLQFFTDRPQASSM
HYLQLENQLRKALELSQLEVFYQPRLSLADDRLEAAEALVRWRHPELGLVAPAQFIPLAEETGLIIPLGEFVLREACRQARQWQLEGLAEIRVSVNLSVK
QLRQGNFVSLVRQVLEETGLPATMLELELTESQLLDDIDNAISISEQLRALGVRLAIDDFGTGFSSLSYLKRFPVDYVKIDRSFICELEHSSQDAAITRA
IIAMVHSLERKVVAEGVETQAQMDFLKANHCDEIQGYLLSPPVPVEQFVELLR-------
>tr|A0A061JMC1|A0A061JMC1_PSEST Diguanylate cyclase OS=Pseudomonas stutzeri KOS6 GN=B597_018640 PE=4 SV=1
-----------------------------------------------------------------------VAEELGKSEERLNLALDASGLGLWDWDLQ
NNRVHH-SRLEVVFGIGQQNHQDDN-GSPLPDIHRDDLDRVRAALIAH-LKGELYVIEYRAVRADGTELCFEDRGRVIRATDGRALRMIGTRRDISELRR
QAEQQRLAAAVFEAASEGMVIMNDRYRVLAVNDACCALSGYSREELLGRSVARISSSPESQRQYEAMREALERHGYWQGELIETRKSGEVYPQWVQLRVV
RDANNSVTHVVAFLSDLSVRRQIEERLRYLTHYDDLTGLANRGLLKERLHQACQRVRRNGRNMAVLYIDLDRFKLLNESLGHEAADALLREVSRRLTQTL
ADADTIARLSGDEFVVLLDAYGGGSLTQLGSRLLRRIRKPMLICDQELVISASIGVSLLPDNSRDPELLLRQANMAMQQSKHLGGNTLQFFTERPQASSM
QYLQLENQLRKALEAGQLEVFYQPRLSLADDALEAAEALVRWRHPQRGLIAPAHFIPLAEETGLIIPLGEFVLREACRQARQWQQEGLAEIRVSVNLSAK
QLRQGNFVSLVRQVLDETGLPAVMLELELTESQLLDDIDNAINISEQLRALGVKLAIDDFGTGFSSLSYLKRFPVDYVKIDRSFICELEHSSQDAAITRA
IIAMVHSLERRVVAEGVETQAQMDFLKAHQCDEIQGYLLSPPVPAEQFAELLR-------
>tr|A4VFY0|A4VFY0_PSEU5 Uncharacterized protein OS=Pseudomonas stutzeri (strain A1501) GN=PST_0174 PE=4 SV=1
-----------------------------------------------------------------------LAEELGESETRLNLALDASGLGLWDWDLQ
NNHVHH-SRLEVVFGIGRQHRHDED-GSPLPDIHPKDLEGVRAILIAH-LKGEQFAVEYRALRADGSEIWLEDRGRVIRDAGGRALRMIGTRRDISELRS
QAEQQRLAATVFEAASEGMVIMNDHYRVLAVNDACCALSGYSREELIGHSVARIAGSQESQRQYQTMREALELHGHWQGELIETRKSGEVYPQWVQLREV
RDANDSVTHVVAFISDLSVRRKIEERLRYLTHYDDLTGLANRGLLKERLHEACQRVRRNGRNMAVLYIDLDRFKLLNESLGHEAADALLREMSRRITQTL
SEADTIARLSGDEFVVLIDAYGSSSLAHLGSRLLQRIRKPVIIDEQELVISASIGVSLMPDNSRDAEVLLRQANMAMQQAKHLGGNTLQFFTDRPQASSM
QYLQLENQLRKALDSGQLEVFYQPRLTLANDALDAAEALVRWRHPERGLVAPAHFIPLAEETGLIIPLGEFVLREACRQARQWQQQGLAEIRISVNLSVK
QLRQGNFVSLVRQVLEETGLPATMLELELTESQLLDDIDNAISISEQLRALGVRLAIDDFGTGFSSLSYLKRFPVDYVKIDRSFISELEHSSQDAAITRA
IIAMVHSLERKVVAEGVETQAQMDFLKANQCDEIQGYLLSPPVPAEQFAELLR-------
>tr|H7EY09|H7EY09_PSEST Putative uncharacterized protein OS=Pseudomonas stutzeri ATCC 14405 = CCUG 16156 GN=PstZobell_14472 PE=4 SV=1
-----------------------------------------------------------------------VAEELGESEARLNLALDASGLGLWDWDLQ
HNRIHH-SRLEVVFGIGLQRRHDED-GSPLPDIHPDDLAGVRATLISH-LKGEFFAVEYRALRADGTEICMEDRGRVIRDASGRALRMIGTRRDISDLRR
QAEQQRLAATVFEAASEGMVIMNAKYRVLAINDACCALSGYSREELLGRSVARIAGSPESQRQYAAMREALERNGYWQGELIETRKSGEVYPQWVQLREV
RDANNSVSHVVAFISDLSVRRKIEERLRYLSQHDDLTGLANRGLLKERLHEACQRGHRNGRNMAVLYIDLDRFKLLNESLGHEAADELLREVSRRLKQTL
ADADTIARLSGDEFVVLLDGYGSSGLAHMGSRLLQRIRKPIIVGDQELVIGASIGVSLLPDNSRDAEVLLRQASTAMQQAKHLGGNTLQFFTDRPQASGM
HYLQLENQLRKALEVGQLEVFYQPRLSLADDSLEAAEALVRWRHPQRGLVTPADFIPLAEETGLIIPLGEFVLREACRQARRWQQEGLADIRVSVNLSVK
QLRQGNFVSLVRQVLEETGLPPAMLELELTESQLLDDIDNAISISEQLRALGVKLAIDDFGTGFSSLSYLKRFPVDYVKIDRSFISEVEHSTQDAAITRA
IIAMVHSLERRVVAEGVETQAQMDFLKANLCDEIQGYLLSPPVPAEQFAELLR-------
>tr|A0A0B5C3W0|A0A0B5C3W0_9PSED Diguanylate cyclase OS=Pseudomonas balearica DSM 6083 GN=CL52_00525 PE=4 SV=1
-----------------------------------------------------------------------VADELRESEARLNLALDASELGLWDWDLA
HAKVLH-TRLEVVFARDDQRAH----DEPLPDIHPDDLPRVRATLIAH-LKGEQYVVEYRAITHDGECLWIEDRGRVIRADNGRALRMIGTRRDISALHQ
QAEQQRLAATVFEAAAEGMVIMDARYRILAINDACCELSGFTRDELLGRSVALLASSVESQRQYSLMRESLERDDQWQGELTEARKNGETYPLWVQLRRV
HGAGGEVSHVVGFLSDLTMRRQAEERLRYLTLYDDLTGLANRSLLKERLHEACQRARQTGRHLAVLFVDLDRFKILNDSLGHEAADSLLREMSRRLAQTF
SDADTIARLSGDEFVVLIESYGSSNLAYLGSRLLARIRKPTIIDGQELVLSASVGISLMPENAREPASLLRQANMAMQQAKHLGGNTLQFFTERQQDSSL
ELLRLENQLRKALVEQQLEVFYQPRLNLTNDRIDAAEALVRWRHPEQGLVPPGQFISLAEETGLIIPLGEFVLREACRQAAQWRLQGVADIRVSVNLSVK
QLRQGNFITLVRQVLEETGLPAERLELELTESQLLDDVDGAIGICRQLRALGVKMAIDDFGTGYSSLSYLKRFPVDYVKVDRSFVAELEHSSEDAAIVRA
IIAMVHSLELKVVAEGVETEAQLAFIRAQRCDEMQGYLISAPVPAERFVTLLR-------
>tr|W9TBE4|W9TBE4_9PSED PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. BAY1663 GN=BAY1663_02861 PE=4 SV=1
-----------------------------------------------------------------------VADELGESEARLSLALEASGLGLWDWDLQ
RNTVHH-SRLEVVFGIDQPRRFDDE-GAALPDVHPDDLPAVRDTLVAH-LKGELYVVEYRASRPDGGFIWLEDRGRVIRDDAGRALRMIGTRRDVSALRQ
QAEQQRLAATVFEAAGEGMVIMDARYRILAINDACCALSGYCREELLGRSVARLASSAESQRQYALMRQSLERDGSWQGELLEVRKNGEVYPQWVQLREV
RDAQGDVSHVVGFVSDMTVRRQAEERLRYLTHYDDLTGLANRGLLKERLHEACQRGRRSGCNMAVLYIDLDRFKILNESLGHEAADQLLREVSRRLSQTL
AEADTIARLSGDEFVVLLDGYGSATLAHVGSRLLARIRKPIVIGEQELVISASIGVSLLPDNSRDAATLLRQANMAMQQAKHLGGNTLQFFTDRPQASSM
EYLQLENQLRKALEVGQLEVFYQPRLSLADDSLEAAEALVRWRHPELGLVAPGQFIPLAEETGLIIPLGEFVLRQACHQARQWQQQGRAEIRISVNLSVK
QLRQGNFVSLVRQVLEESGLPPQMLELELTESQLLDDIDSAIGISQQLRALGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDRSFISGLEHSSEDAAITRA
IIAMVHSLERKVVAEGVETQAQMDFLKANRCDEIQATCSARRCRWNSSSSCWDSAR----
>tr|L1LY16|L1LY16_PSEPU Sensory box protein OS=Pseudomonas putida CSV86 GN=CSV86_18928 PE=4 SV=1
-----------------------------------------------------------------------ANQALSKSEQRLALALEASELGLWDWNLQ
TDEVHH-TQLRELFGLNPDAVKAML-VHLKPRLHPDDVQALKRTLVEH-LKGEDYRIEYRFRHNDGHWCWIEDRGRAVRDAEGRVVRMIGTRRDISARRA
QEEQQRLAATVFEAASEGIAILGPDYELLALNQAFCRMTGYGREELLGRNALELPCSLDARRHYGAIDQALEQNGRWQGELVEARKDGTLYPQWLQLNGV
FDGRGKISNVVGFFSDLSERRESEERLRYLAHYDELTGLANRALFRLRLLEAGQRLRTSGRCLALMHIDLDRFKLLNDSLGHEVADQLLKQIAMRIGNAM
AEADTVARLSGDEFVVLFDGYSSSSLVRVATRLLEKLRVPVRFDNHELVISASVGIALHSDMSLDLNVLVSQANMAMQHAKHLGGDNFQFYTESLQASTL
DRLQLENQLRKAIDEGQLEVYYQPKVCLTSGRIEAAEALVRWNHPVMGMVPPGEFIGLAEETGLIAPMGEFVLRQSCWQACEWQRQGLEPIRVSVNLSVY
QLRQGKLVSLVRQVLEESGLAPHLLELELTESQLLDSVEHIIATFKQLHELGVKLAIDDFGTGYSSLSYLKRLPVDYVKIDQAFIRGLEEGSEDAAITRA
IIIMAHSLDLMVVAEGVETEEQLRFLREQDCDEVQGYLISRPLQADALARLLSEQT----
>tr|L0WC16|L0WC16_9GAMM Sensory box protein OS=Alcanivorax hongdengensis A-11-3 GN=A11A3_07880 PE=4 SV=1
-----------------------------------------------------------------------SNKALTDTGEQLQLALEASNIGLWDWMLE
TGHNYH-TNFDRLLGYDSAYFRNFF-GDLEELVHPDDLPRIRRAMVAH-FKGDSYHAVYRLRHADGEWRWIEDDGRVVRAKSGRALRMIGTRRDITDDRQ
AQEQLRLAATVFENAPEGIFILDNQFRFQAVNARFEQITGYTESMVLGKQVLDHEGTTANSDTYKMITAALKENGFWEGEINEKRHNGEHFPEWLQVSAV
RDEQKRVIRYVGMISDLTTRKETEEQLQFLSNFDRLTGLANRSQFREHLHKSLTLARLNREKVALLMIDLDRFKPINESLGHEIGDRLLKAAADRICECG
VPTEDMARVGGDEFTLLMENFPNAAVSNLSQKVINALKKPFMIDGHELLLGGSIGISIFPDTAKEAQSMINQADMAVYQAKRSGGNSYQYYRGNMRVASV
EQLALETSLRKAIFKNEFVIYYQPKMDLGSGRITSVEALVRWQHPTMGLLPPSDFIPLAEESGLISAIGELVMERACRHARQWHQQGLGDICVSVNLSAH
QFRKGNVAQIIDRVLDSTGLPAHLLELELTESLIMEDMDQNITLLQELRTRGIELALDDFGTGYSSLSYLKRFPVDTLKIDRSFIMEMDTSPDDAAITRA
IIDMAHSLKMRVIAEGVETAAHLEMLREMGCDGIQGFYISKPVPETRLQEILRDQI----
>tr|A0A095S604|A0A095S604_9GAMM Sensory box protein OS=Alcanivorax jadensis T9 GN=T9A_02814 PE=4 SV=1
-----------------------------------------------------------------------TNQALAATGERLELALEASNIGLWDWMLD
TGRNYH-TNFDRLLGYDGAYFKNFF-GDLETLVHPEDLTRIRRAMVSH-FKGDRYHAVYRLRHADGSWRWIEDEGRVVWSDQGRALRMIGTRRDITEDRQ
SQEQLRLAATVFDNAPEGIFILDHKFRFLAVNARFEQITGYSESMVLGKQVLDHQETAANRDTYKMITAALRETGFWEGEISETRRNGEPFPEWLQVSAV
RDEHKKVIRFVGMMSDLTTRKETEQQLQFLSNYDRLTGLANRTQFREHLHKSLTLARLNREKVALLMIDLDRFKPINESLGHEIGDRLLKAAAERMAQHA
GGEENLARVGGDEFTLLLENHGGGAISQHCQKLINAMKKPFMIDGHELLLGASVGISVFPDTAKEAQSMINQADMAVYQAKRSGGNNFQFYRSNMRVASV
EQLALETSLRKAIFKNEFVVYYQPKMDLASNRITSVEALVRWQHPTMGLLPPADFIPLAEETGLISAIGELVLERSCRQAHQWYKQGLGNICVSVNLSAH
QFRKGNVAEIVDRVLESTELPAHLLELELTESLIMEDMEQNIELLQQLRTRGIELALDDFGTGYSSLSYLKRFPVDTLKIDRSFIMDLDKSPDDAAITRA
IIDMAHSLQMNVVAEGVETEAHLSILRDMHCDSIQGFLISRPVPEKELVELLHTQA----
>tr|A0A095SFG6|A0A095SFG6_9GAMM Sensory box protein OS=Alcanivorax sp. 19-m-6 GN=Y5S_03462 PE=4 SV=1
-----------------------------------------------------------------------TNQALGATSERLELALEASNIGLWDWMLD
TGRNYH-TNFDRLLGYDSAYFKNFF-GDLETLVHPDDLTRVRRAMVSH-FKGDRYHAVYRLRHADGEWRWIEDDGRVVWSDKGRATRMIGTRRDITEDRQ
AQEQQRLAATVFENAPEGIFILDHKFRFLAVNARFEQITGYSESVVLGKQVLDHDDTQPNRDTYVEITNALNESGFWEGEINEKRRNGESFPEWLQVSAV
RDEQKRVIRYVGMITDLTSRKETEQQLQFLSNYDRLTGLANRSQFREHLHKSLTLARLNREKVALLMIDLDRFKPINESLGHEIGDRLLKAAAERLSHFA
GEEEHLARVGGDEFTLLVEKYSNATVSQLCQKIINAMKKPFLIDGHELLLGASIGISIFPDTAKEAQSMINQSDMAVYQAKRSGGNNFQFYRGNMRVASV
EQLALETSLRKAIFKNEFVVHYQPKMELANNRITSVEALVRWQHPTMGLIPPSEFIPLAEETGLISAIGELVLERSCRHAHKWYKQGLGDITVSVNLSAH
QFRKGNVADIVDRVLSSTELPPQLLELELTESLIMEDMEQNIEMLQQLRKRGIELALDDFGTGYSSLSYLKRFPVDTLKIDRSFIMDLDKNPDDAAITRA
IIDMAHSLQMNVVAEGVETEEHLSILRGMSCDTIQGFLISKPLPEEELVELLHTQA----
>tr|Q0VL09|Q0VL09_ALCBS Uncharacterized protein OS=Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2) GN=ABO_2691 PE=4 SV=1
-----------------------------------------------------------------------TNTALAATSERLELALEASNIGLWDWMLD
TGLNHH-TNFDRLLGYDSAYFKNFF-GDLDTLVHPDDLARIRQAMVSH-FKGPRYHAVYRLRHADGSWRWIEDEGRVVRSESGRAIRMIGTRRDITEDRQ
AQEQQRLAATVFENAPEGIFILDHKFRFLAVNTRFEQITGYTESLLIGRRILEEEGAQANREIYLEITAALLDNGFWEGEINERRRNGEIYPEWLQMSAV
RDEQKRVIRYVGMMSDLTARKETEQQLQFLSNYDRLTGLANRTQFREHLHKSLTLARLNRQKVALLMIDLDRFKPINESLGHEIGDRLLKAAAERMAQHA
GGQESLARVGGDEFTLLLENHGSGSISQQCQQLINAMKKPFLIDGHELLLGASIGISIFPDTAKEAQSMINQSDMAVYQAKRSGGNNFQFYRSNMRVASV
EQLALETSLRKAIFKNEFVVHYQPKMNLASNRITSVEALVRWQHPTMGLLPPADFIPLAEETGLISAIGELVLERSCRQAHKWQKQGLGEICVSVNLSAH
QFRKGNVAETIDRVLSTTELSPHLLELELTESLIMEDMEQNIELLQQLRSRGVELALDDFGTGYSSLSYLKRFPVDTLKIDRSFIMELDKNPDDAAITRA
IIDMAHSLKMNVIAEGVETADHLSILRDMHCDSIQGYLISRPVPESELLELLHTQA----
>tr|K0CGH0|K0CGH0_ALCDB PAS fold family OS=Alcanivorax dieselolei (strain DSM 16502 / CGMCC 1.3690 / B-5) GN=B5T_04374 PE=4 SV=1
-----------------------------------------------------------------------ANRELTATGERLELALEASNIGLWDWNLN
TGSNYH-TNFDRLLGYENEYFGNFF-GDLKQLVHPDDFPTIRRGMVAH-FKGDRYHAIYRLRHKQGHWCWLEDDGRVVWDDNGRAIRMIGTRRDITSQRE
AQEQQRLAATVFENAPEGIFILDRQFRFLAANARFEQITGYREEEMNGKSIADSEHARRHRNLYHTIRVGLRRNGFWEGEITGRRRNGEIFPEWVQISSV
LDERQRVIRYVGMISDLTSRKEAEERVRFLSNYDRLTGLPNRTLFRERLHKALTLGRLNRSRVALLMIDLDRFKPINESLGHEIGDRLLKLAADRISQCG
PGDESLARVGGDEFALVLDNCGGPQIGALCQKIINAMKKPFLIDSHELLLGASIGISLFPSTAMDAQPMINQADMAVHQAKRSGGNNYQFYRSGMQVASV
EQLALETSLRKAIFKNEFVVHYQPKMDLASNAVSSVEALVRWQHPSMGLLPPSEFIPLAEESGLISAIGELVLERSCRQAHQWHKQGLGNIRVSVNLSAH
QFRKGNLADVIDRVLDLTGLPAHLLELELTESLIMEDLEQNIALLERLRSRGIGLSLDDFGTGYSSLSYLKRFPVDTLKIDRSFITDLTQNADDAAITRA
IIEMAHSLNMSVVAEGVETAQHLEILRAMGCDGIQGFLISRPVEENKIREMLRDQH----
>tr|A0A0B4XU75|A0A0B4XU75_9GAMM Sensory box protein OS=Alcanivorax pacificus W11-5 GN=S7S_18080 PE=4 SV=1
-----------------------------------------------------------------------MNTELAATSQRLQLALDASNICLWDWNLV
TGETFH-SNFDRLLGFDDSTVGNFV-EDLRKLVHPSDFPLIRQAMVDH-FKGTQYQVVYRMQHADGRWHWIADEGRVVWNQQGRATRMIGTRRDITEDKE
AREQLRLAATVFENASEGIFIFDRNFRFLTVNDCFTRITGYQDREVVSHSVMDIGNVPENEKLYREILSALGKEGFWEGELTERRKSGERYPEWLQISAV
YDESGRLTHYVGMFSDLTARKEAEERVQFLSNFDRLTGFANRNQFRERLQKCLTLSRLNRKKAALVFIDLDRFRPINDSLGHEVGDRLLKLAAERLRGCG
FDEDNLARVGGDEFTLIVEQYSDRALEHVCNKLINAMRRPFHFDQHELLLGASVGISVFPDTAQDVQTLINQADLAMHQAKRAGGNNFQFYSSDMRVASV
EQLALETSLRKAIFKNEFVVHYQPKMDLGRNCITSVEALVRWQHPTMGLLPPKDFIPLAEETGLISAIGELVLERSCRQAMQWYNSGLGDICVSVNLSAH
QFRKGNVLEIVDRVLETTGLPAELLELELTESLIMEDLDKNIALLQALRTRGVELSLDDFGTGYSSLSYLKRFPIDTLKIDRSFITELDQSPDDAAITRA
IIDMAHSLNLRVVAEGVETDSHLEILRGMGCDSIQGYLISRPVPEAELLQLLETQK----
>tr|U2ZB52|U2ZB52_PSEAC Uncharacterized protein OS=Pseudomonas alcaligenes NBRC 14159 GN=PA6_055_00080 PE=4 SV=1
-----------------------------------------------------------------------ASHALGKSEERLALALEASELGLWDWNLE
TDEVHH-SHLESIFGISQEEVKGVL-SHLKPRLHPDDLPLLRRALVEH-LKGDGYCVEYRVRHADGRWRWVEDRGRAVRNAQGQVLRMLGTRRDITERKL
VDEQQRLAATVFEACGEGIVILDADYLILSVNQAFSDVTGYRKDEVLGRSVATLISSHETRRQYQLIREQLELHGSWRGELVETRKNGELYPQWLQLNAV
QDGRGRVSHIVGFFSDLSQRRQTEERLRYLSHYDELTGLANRSLFRERLHTACELARHSDAQMALLHIDLDRFKLLNDSLGHEVADQLLRQMARRLNQSV
PEAHTVARLAGDEFAILLDDYGSSALARTASRLLAKLRTPMDVAGHELVVSASIGISLLPDNARELAALLSQADMAKQHAKHLGGNTFQFYTDNLQACTL
ERLQLENQLRKAIEEHQLEVFYQPKLCLLDDSLNAAEALVRWRHPELGLVPPSDFIPLAEETGLIAPIGEFVLRQACRQAREWQRQGLADLRVSVNLSVH
QLRQGNLVGLVRQVLDESGLPSRLLELELTESHLLDNVENVITTFQQLRDLGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQTFVRDLAAGGEDAAITRA
IIAMAHGLELKVVAEGVETQAQMDFLKLQRCDEIQGYLISPPVPAEQFAELLRAQA----
>tr|A0A0D6SSD7|A0A0D6SSD7_9PSED Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudomonas sp. FeS53a GN=SZ55_2340 PE=4 
-----------------------------------------------------------------------ATHALAKSEARLALALEASELGLWDWNLE
TDEVHH-TQLKAIFGLESDEVSRVL-SDLRPCLHPDDVPLLRRALVDH-LKGEDYAVDYRVRHRDGRWIWVEDRGRAVRDARGRVLRMVGTRRDVTARRQ
AEEQQRLAATVFEAASEGIVILDPDYRLLAVNQAFTQVTGYRAEEVLGRAVAEISGTRESRRQYHLIHQQLEHDGCWQGELVDTRKNGELYPQWLQLNVV
RDSRGQASHIVGFFSDLSARREAEERLRYLSHYDDLTGLANRTLFRDRLHQASERAREHGHGLALLHIDLDRFKVLNDSLGHELADQLLRQMGRRLAQAA
PEADTIARLSGDEFALILDRYGSSSLARTASRLLAKLRTPMTVGGEELVVSASLGISLLPDNAREITTLVSQANMAMQHAKHLGGNTFQFFTDNLQACTL
ERLQLETQLRKAIDEGQLEVFYQPKLCLADDSLNAAEALVRWRHPQMGLVPPGDFIGLAEETGLIAPIGEFVLRQACLQARDWQRQGVADIRVSVNLSGH
QLRQGNLVALVRQVLAETGLPPRLLELELTESHLLENVEHVIATFHQLRELGVKLAIDDFGTGYSSLSYLKRFPVHYVKIDQTFIRDLSLGGEDAAITRA
IIAMAHGLELKVVAEGVETTEQLDFLKEQGCDEIQGYLLSPPVEASAFTALLREQS----
>tr|A0A0A1YPU1|A0A0A1YPU1_9PSED Diguanylate cyclase OS=Pseudomonas taeanensis MS-3 GN=TMS3_0103120 PE=4 SV=1
-----------------------------------------------------------------------TTHALSKSQARLALALEASELGLWDWDLQ
SDQVHH-SQLKEIFGLEPGAVQVML-RDLKPRLHPDDLPVLRRALVEH-MKGDGYQIEYRIKHAAGHWVWIEDRGRAVHDARGRVLRMLGTRRDISARKQ
QEQQQQLAATVFEAASEGIVILDPDYRLLAVNRAFRQVTGYRQDELIGKSVISFISSREARQQYQLIRLELEQCGSWQGELLEARKNGELYPQWLQLNVV
RDSRGNVSHVVGFFADLTSRRESEERLRYLSHYDQLTGLANRSLFRERLHDASQRARQSGRSLALLHIDLDRFKLLNDSLGHDVADQLLRQMSRRLSQAV
PEADTLARLSGDEFGVLLDSYGSSSLARMASRLLAKLRVPMTVGDQELVISASVGISLWPDNAREISALISQANMAMQHAKHLGGNTFQFFTDNLQACTL
ERLQLETQLRKAIDEGQLEVFYQPKLCLADDSLNGAEALVRWRHPLLGLVPPGDFIGLAEETGLIAPIGEFVLREACRQAREWQRQGLAQIRVSVNLSVH
QLRQGNLTSLVRQVLEETDLEAHFLELELTESQLMENVESVISTFHQLRALGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQTFIRDLSAGGEDAAITRA
IIALAHSLELKVVAEGVETQAQMDFLKAHHCDEIQGYLIGRPVPAEQFVEVLRDQI----
>tr|S6AQ65|S6AQ65_PSERE Putative signaling protein OS=Pseudomonas resinovorans NBRC 106553 GN=PCA10_56030 PE=4 SV=1
-----------------------------------------------------------------------ASHALSKSEARLGLALEASELGLWDWNLE
TDEVHH-SQLKAIFGIEGDDITRVL-SDLKPRLHPEDLPLLRRALVEH-LKGDGYSIDYRVRHADGHWVWVEDRGRVVRDEHGKVLRMLGTRRDITARKA
QDEEQRLAATVFEAASEGIIILDPEYRVIQANAAFSQVTGYRQEEVIGHSVATLLGTRETRRRYHLIRQDLEQSGSWSGELMDTRKNGELYPQWLQLNVV
RDSRGCVSHVVGFFADLTARREAEERLRYLSNYDELTGLANRTLFKDRLHEASQRARQSGRSLALLHIDLDRFKVLNDSLGHEVADQLLRQVSRRLTQAV
PEADTIARLSGDEFAVILDAYGSASLARQASRLLGKLRMPMTVGGHELVISGSLGISLLPDNARDISALISQANMAMQHAKHLGGNSFQFFTDNLQACTL
ERLQLENQLRKAIAEGQLEVFYQPKLCLADNSLNAAEALVRWRHPQQGLVPPGDFIGLAEETGLIAPIGEFVLRQACQQAREWQRQGLADIRVSVNLSMH
QLRQGNLVSLVREVLAETGLAAHLLELELTESHLLENVENVIATFHQLRKLGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQTFIRDLSAGSEDAAITRA
IIAMVHSLELMVVAEGVETQEQLSFLRSQHCDEIQGYLISPPVPAPQFARLLEEQA----
>tr|A0A0B3BWT3|A0A0B3BWT3_9PSED Diguanylate cyclase OS=Pseudomonas tuomuerensis GN=PT85_15360 PE=4 SV=1
-----------------------------------------------------------------------ATYALGKSQARLAMALEASELGLWDWNLR
TDEVHH-SKLQELFGLAPTGTLNMR-RDLRPLLHPDDRRLLLHALSAH-MRGDGYAVEYRVRHADGYWVWVEDRGRVMRDERGRVVRMLGTRRNITARKR
REEEQRLAATVFETASEGIVVLDRHYQVLAVNRAFCVMTGYRREEAVGRNVTQLVSSPDTHRQYRQIHAQLLAHGRWQGEMMETRKNGELYPQWLQINAV
RDRNGRITQMVGFFADLSARRQAEERLRYLSNYDALTGLANRMLFKERLHEAGQRSRQTGRSLALLHIDLDRFKLLNDSLGHEVADQVLRNMGRRLSEQL
AEADTLARLAADEFVVLFDQYSNSSLSRLASQLLAKLRAPMTVDGHELVISASIGISLLPENAREVSALITQANMAMQHAKHLGGDNFQFFTDNLQACTL
ERLQLENQLRKAIDSGQLEVFYQPKLDLSLDSLQAAEALVRWRHPQRGLVSPADFIPLAEETGLIGAIGEFVLRRAASQACEWRQQGLGDIRVSVNVSVH
QLRQGNLTTLVRRVLEETGLPAHLLELELTESQLLDNVESVLHTLNQLRELGVKLAIDDFGTGYSSLSYLKRLPVDYLKIDRTFVRDLTEDGEDAAITRA
IIAMAHSLELKVVAEGVEEQQQLDFLKSQGCDEIQGFLISRPIEAIHFASLLREQE----
>tr|U3HAF0|U3HAF0_PSEAC Diguanylate cyclase OS=Pseudomonas alcaligenes OT 69 GN=L682_20560 PE=4 SV=1
-----------------------------------------------------------------------ASHALVKSEARLAMALEASELGMWDWNLE
TDEVHH-SHLKEIFGIEMDDVTRVL-SDLKPRLHPDDLPLLRRALVEH-LKGDGYAIDYRVRHSDGRWLWVEDRGRVVRNEQGKVLRMLGTRRDVTERKQ
AEEQQRLSAMVFEAASEGIVILDPQYRLLAVNQAFSDVTGYRRDEVLGHTVVEINSTRESRRQYHLIRQELEQSGSWQGELVDTRKNGELYPQWLQLNVV
RDARGNASHIVGFFADLSARRDAEERLRYLSHYDELTGLANRTLFKDRLHEASQRARQSGRSLALLHIDLDRFKVLNDSLGHEVADQLLRQMSRRLAQAA
PEADTIARLSGDEFAVILDAYGSSSLARTASRLLAKLRTPMTVGGEELVVSASLGISLLPDNAREISTLISQANMAMQHAKHLGGNTFQFFTDNLQACTL
ERLQMETQLRKAIEEGQLEVFYQPKLCLADDSLNAAEALVRWRHPQLGLVPPGDFIGLAEETGLIAPLGEFVLRQACLQAREWQRQGLADIRVSVNLSGH
QLRQGNLTSLVRQVLDETGLSPRLLELELTESHLLENVEHVIATFRQLRDLGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQTFIRDLSSGGEDAAITRA
IIAMAHGLELKVVAEGVETQGQMDFLKSQGCDEIQGYLISPPVEAPVFAALLKEQA----
>tr|A0A061CXV2|A0A061CXV2_PSEPS Uncharacterized protein OS=Pseudomonas pseudoalcaligenes GN=PPSAL_4265 PE=4 SV=1
-----------------------------------------------------------------------ATHALGTSQERLALALEASELGLWDWDLE
SDQVHH-SHLRELFGLEPEQVQVML-RDLTPRLHPDDLPGLRRALVRH-LKGEDYQIEYRVRHVDGHWVWVEDRGRAVRDAAGRVRRMLGTRRDVSARRQ
QEQQQRLAATVFEAASEGIFILDPDYCVLAVNRAFSAVTGYSREEVVGRTVTSLIGNREMRRQYQMIRQELDSTGTWQGELIETRKSGELYPQWLQLNLV
RDVTGRPSHIVGFFADLSARREAEERLRYLSHYDDLTGLANRSLFKERLHDASQRARQSGRSIALVHIDLDRFKLLNDSLGHEVADQLLRQMSRRLTQAV
PEADCIARLSGDEFAIILDAYGSSSLARVASRLLAKLRVPMTVGGHELVISASLGISLMPDYAREISALISQANMAVQHAKHLGGNTFQFFTDNLQACTL
ERLQLENQLRKAIDEGQLEVFYQPKLNLADGQLNAAEALVRWRHPQQGMVPPSEFIGLAEETGLIAPIGEFVLRQACRQARQWQEEGLAQIRVSVNISVY
QLRQGNLTSLVRQVLEETGLAPQYLELELTESQLLDNVDSVIVTFRQLRELGVKLAIDDFGTGYSSLSYLKRFPVHYVKIDQTFIRDLSPGGEDAAITRA
IIAMAHSLELKVVAEGVETQAQMDFLKSQNCDEIQGFLISRPVEASTFAELLRAQI----
>tr|L8MQY8|L8MQY8_PSEPS Sensory box/GGDEF family protein OS=Pseudomonas pseudoalcaligenes KF707 GN=ppKF707_5403 PE=4 SV=1
-----------------------------------------------------------------------ATHALAKSEARLALALEASELGLWDWNLE
TDEVHH-SQLKAIFGIEEEEVTRVL-SDLKPRLHPDDLPLLRRALVEH-LKGDGYAIDYRVRHKDGHWVWVEDRGRVVRNAEGKVLRMIGTRSDITARKL
REEEQRLSATVFEAASEGIVILDPDYRIIQANAAFSQVTGYRQDEVLDRNLSTLIGSRETRRRLHMIRAELELSGSWQGELTDIRKNGELYPQWLQLNVV
RDSRGNVSHIVGFFADLSARREAEERLRYLSHYDELTGLANRTLFKDRLHEACERARHGGRSLALLHIDLDRFKVLNDSLGHEVADQLLRQVSRRLTQAM
PEADTIARLSGDEFAVILDAYGNASLARQASRLLGKLRMPMDVGGHELVISGSLGISLLPDNARDISALLSQANMAMQHAKHLGGNSFQFFTDNLQACTL
ERLQMETQLRKGIEEGQLEVFYQPKLCLADNSLNAAEALVRWRHPQLGLVPPGDFIGLAEETGLIAPIGEFVLRQACLQARDWQRQGLADIRVSVNLSMH
QLRQGKLVCLVRQVLEETGLPARLLELELTESHLLENVENVIATFHQLRQIGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQTFIRDLSAGSEDAAITRA
IIAMAHSLELKVVAEGVENQEQLNFLRSQRCDEIQGYLISPPVEVPCFVRLLQEQA----
>tr|A0A024H9M0|A0A024H9M0_PSESB Uncharacterized protein OS=Pseudomonas knackmussii B13 GN=PKB_0161 PE=4 SV=1
--------------------------------------------------------------------------ELSDSQARLALALEASELGLWDWNLE
TDEVHH-SRLEEIFGISQDEVRSVR-ADLRPRLHPDDVPLLRRALVNH-LKGDGYCIEYRVRHADGHWVWVEDRGRVMRDARGKVTRMVGTRCDISARKR
REEEQRLAATVFEAASEGIVILDPEYRLLAVNQAFSRVTGHRAEDVIGKFAARLSGNTDTLRQYLQIREELEEVGSWQGELLETRKNGEIYPQWLQLNVV
RDNRGQVAHVVGFFADLTARRDAEERLRYLSHYDELTGLANRGLFKQRLHDAGQRARQNGRSLALLLIDMDRFKLLNDSLGHEVGDQLLRQIARRLTQTV
PEADTIARLSADEFAVLIDSYSSSALARLSSRLLTSLRMPMSAGGQELVVSASLGISLLPENAREISALMSQANMAMQHSKHLGGNTFQFFTDNLQASTV
ERLQMEVQLRKAIEEGQLEVYYQPKLNLANERLDSAEALVRWRHPQLGMVPPGEFIALAEETGLIGAIGEFVLRRACRQLRDWQAQGMGDLRVSVNLSVH
QLRQGNLISLVRTVLDETGLAPQWLELELTESQLLENVESVCATFRQLREMGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQTFIRDLSAQGEDAAITRA
IIAMVHSLELKVVAEGVERQEQLDFLRQHQCDEIQGYLISVPLAASAFAEFLRRVP----
>tr|A0A0C2I1D5|A0A0C2I1D5_9PSED Sensory box/GGDEF family protein OS=Pseudomonas batumici GN=UCMB321_5470 PE=4 SV=1
-----------------------------------------------------------------------ANQALSKSETRLALALQASELGLWDWNLQ
TDEVHH-TQLKELFGLDPEYVTAVL-GHLKPRLHPEDVPALKRALVEH-LKGEDYVIEYRVRHGDGHWVWIEDRGRAVRTASGRVSRMVGTRRDISAHKE
QEAQRQLAATVFEAASEGIVIFDPHYVLLAINQAFSRVTGYLPEDMLGRNVVDLPCSRDARRHYSIIHQALEQHGSWQGELVEARKNGELYPQWLQLNVV
RDTRGNVSHIVGFFADLSARRESEERMRYLTHYDELTGLANRSLFRERLYEVHQRVRQGGRSLALLHINLDRFKLLNDSLGHEVADQLLQQMARRLVNAL
PEANTIARLSGDEFAVLFDAYGNSSLARVATRLLGKLRVPVTIEEHELVVSASMGISLLPDNAREIPLLLSQSNIAMQHAKHLGGNNFQFYTESLQASTL
ERLQLENQLRKAIEEQQLSVFYQPKLCLASGRVNAAEALVRWEHPVLGQVPPGDFIGLAEETGLIGPIGEFVLRQACWQACEWQREGLAAIRVSVNLSVH
QLRQGKLVSLVRQVLEETGLAPELLELELTESQLLDSVEHIIATFQQLRDLGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQSFIRGLGEGSEDAAITRA
IIAMAHSLELKVVAEGVENQEQLDFLKAQGCDEVQGYLISRPVAAQELMRRLREGF----
>tr|M4X400|M4X400_PSEDE PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas denitrificans ATCC 13867 GN=H681_24810 PE=4 SV=1
--------------------------------------------------------------------------QLSHTEARLALALEASELGLWDWNLL
TDEVHH-SHLEEIFGLTQAAVKSVR-NDLRPRLHPDDLPLLRRALVEH-LKGDGYRIEYRVRHADGHWVWVEDRGRAMRDARGRVTRMVGTRCDISTRKL
REEEQRLAATVFEAASEGIIILDPSYRLIALNEAFTRLTGYRREELLGRNASRLMDSAETLRRYQAIRTELERQGTWQGELIETRKNGELYPQWLQLNVV
RDGRGQVTHVVGFFADLTARRDAEERLRYLSHYDELTGLANRTLFKERLHEASQRARQEGRTAALLLIDLDRFKLLNDSLGHEVADQLLRQMARRMTQTV
PEADTIARLSGNEFAVLIDSYASAALARLSSRLLAKLRTPMTVGGHELVISASVGISLLPDNAWEISALMSQANMAMHHAKHLGGNTFQFFTDNLQACTL
ERLQLETRLRKAIDEGQLDVHYQPKLNLANERLDSAEALVRWRHPELGMVPPGDFIGLAEETGLIGAIGEFVLRRACQQARAWQLQGH-ELRVSVNLSVH
QLRTGNLVELVRAVLDETGLPPNLLELELTESQLLDNVESVTVTFRQLREMGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQTFIRDLSERGEDAAITRA
IIAMAHSLELKVVAEGVEHPEQLRFLRAHGCDEIQGYLISQPLPAEECQALLEENG----
>tr|A0A081YBI0|A0A081YBI0_9PSED Diguanylate cyclase OS=Pseudomonas sp. AAC GN=FG99_13755 PE=4 SV=1
--------------------------------------------------------------------------ELSNSQARLAMALEASELGLWDWNLR
TDEVHH-SRLREIFGLDQDAVRSMR-ADLRPLLHPDDVPLLRRALADH-LRGDGYRVEYRVRHADGHWVWVEDRGRVMRDARGKVTRMVGTRCDVSARKR
REEEQRLAATVFEAASEGIVILDADYRLLAVNQAFSRVTGHRPEEVIGQVATSLSGNPETRRQYLLIREELERAGSWQGELLETRKNGEPYPQWLQLNMV
RDNRGQLSHVVGFFADLTARRDAEERLRYLSHYDELTGLANRGLFKQRLHDAGQRARHSGRSLALLLIDLDRFKLLNDSLGHEVGDQLLRQIARRLTQAV
PEADTIARLSADEFAVLVDSYSSSALARLSSRLLTRLRMPMSVAGEELMLSASLGISLLPENAREISALMSQANMAMQHAKHLGGNTFQFFTDNLQACTL
ERLQLEVQLRKAVEDGQLEVHYQPKLNLANGRLDSAEALVRWRHPLQGMIPPGDFIPLAEEAGLIGAIGEFVLRRACHQGRTWQARGLAELRVSVNLSVH
QLRQGNLVSLVRTVLDETGLEPRLLELEITESQLLENVESVSTTFRQLREMGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQTFIRDLSAQGEDAAITRA
IIAMVHSLELKVVAEGVERQEQLDFLRQHRCDEIQGYLISPPLAPAAFTAFLEAHG----
>tr|J3C2H0|J3C2H0_9PSED PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Pseudomonas sp. GM74 GN=PMI34_00148 PE=4 SV=1
-----------------------------------------------------------------------ANQALSKSEARLALALKASELGLWDWNLQ
TDEVHH-TQIQELFGLEPEQVTALL-RHLKPRLHPEDLPALKRALVEH-LKGEDYQIEYRVRHGDGHWVWIEDRGRAVRADNGRVIRMVGTRRDISASKS
LEEQRQLAATVFEAASEGIVIFDPNYVLIAINQAFSRVTGYDIDDMIGRNVVELPCSRDARRHYAAIHQALEQQGSWQGELVETRKNGEMYPQWLQLNAV
RDTRGNVSHIVGFFADLSARRESEERMRYLTHYDELTGLANRAMFRERLSEAHQRVRQGGRSLALLHINLDRFKQLNDSLGHEVADQLLQKMARRLVNAL
PEADTIARLSGDEFAVLFNAYGNSSLARVATRLANKLRLPVTIDGHELVVSASMGISLLPDSAREISALVSQSNMAMQHAKHLGGDNFQFYTDSLQASTL
ERLQLENHLRKAIEDKQLKVFYQPKLCLATGRLNAAEALVRWDHPTMGRVPPGDFIGLAEETGLIGPIGEFVLRQACWQACEWQRQGLEPIRVSVNLSVH
QLRQGKLVSLVRQVLEETGLASHYLELELTESQLLDSVEHIIATFQQLRDLGVKLAIDDFGTGYSSLSYLKRIPVDYVKIDQAFIRGLGEGSEDAAITRA
IIAMAHGLKLKVVAEGVEREEQLEFLKAECCDEVQGYLISRPVEAEALAGLLHAQA----
>tr|I4N7J8|I4N7J8_9PSED Putative sensory box/GGDEF family protein OS=Pseudomonas sp. M47T1 GN=PMM47T1_06626 PE=4 SV=1
-----------------------------------------------------------------------ANQALSKSEARLALALDASELGLWDWDLQ
SDEVHH-THVQELFGLAPEYVTAML-RHLKPRLHPEDLPHLKRTLVEH-MKGEDYRIEYRIRHSDGRWRWIEDRGRAVRAESGKVLRMLGTRRDISASKA
HEDHQRLSAMVFEAASEGIIILDSDYAVLSVNEAFVTVTGYSREEVLGRSVIELPCSRDARRHHRQIDEALQHAGQWQGELVEARKNGELYPQWLQLSVV
RDHRENISHIIAFCADLSARRESEERMRFLTHYDELTGLANRALFRERLQEANLRVRQGGRSLALLHINLDRFKLLNETLGHEAADQLLKQMARRITNAL
PEADTIARLSGDEFAVLFDAYANSSLARVTSRLLAKLRVPQMIENQELVVSASIGISLLPDNAREVSALVGQAIMAMQHAKHLGGNNFQFYTDSLQASTM
ERLQLEQQLRKAIDEQQLEVYYQPKLCLDSGRLNGAEALVRWRHPTMGMVPPGEFIGLAEETGLIVPIGEWVLRQACWQAREWQRQGLRAIRVSVNLSVH
QLRQGKLVSLVRQVLNDTGLEPQFLELELTESQLLDSVEHIIATFHQLQALGIKLAIDDFGTGYSSLSYLKRFPVDYVKIDQAFIRGLAEGSEDAAITRA
IIAMAHSLQLKVVAEGVETQAQLSFLNVHGCDEIQGYLISKPVEAQAFGGLLADDR----
>tr|A0A0D1MS73|A0A0D1MS73_PSEPU Pseudomonas putida strain UASWS0946 Contig166, whole genome shotgun sequence OS=Pseudomonas putida GN=QV12_10565 PE=4 SV=1
-----------------------------------------------------------------------ANQALSKSEQRLALALEASELGLWDWNLE
TDEVHH-TQLHELFGLNPEQVRAVQ-AHLKPRLHPDDVPALKRALVDH-LKGDDYRIEYRFRHAQGHWCWIEDRGRAVRDAAGRVVRMLGTRRDVSARKA
QQEQQRLAATVFEAASEGIAIMGPDYAVLAANQAFCHMTGYVREELLGRNALELPCSRDARRHYGAIDQALAQQGRWEGELVEARKSGELYPQWLQLTGV
TDARGQVGTIVGFFTDLSARRESEERLRYLAHYDELTGLANRALFRLRLHEAGQRLRGSGRSLALLHIDLDRFKLLNDSLGHELADRLLKTMAQRIGNAV
PEADTVARLSGDEFVVLFDGYSHSSLVRVATRLLDKLRVPLRVDGHELVISASVGVSLLPDASLDVSTLVSQANMAMQHAKHLGGDGFQFYTESLQASTL
ERLQLENQLRKAIEERQLEVYYQPKLCLASGRLQAAEALVRWHHPQVGMVPPGDFIGLAEETGLIAPMGEFVLRQACWQACEWQRQGLAPIRVSVNLSVY
QLRQGKLVSLVRQVLEDSGLAPHLLELELTESQLLDSVEHIIATFHQLHELGVKLAIDDFGTGYSSLSYLKRFPVNYVKIDQTFIRGLHEGSEDAAITRA
IIVMAHSLGLQVVAEGVETQEQLAFLREQGCDEVQGYLISRPVEADSLAALLREDR----
>tr|A0A031J6Q2|A0A031J6Q2_9PSED Putative sensory box/GGDEF family protein OS=Pseudomonas sp. RIT357 GN=BW43_00548 PE=4 SV=1
-----------------------------------------------------------------------ASLALNKSEARLAMALQASELGLWDWNLQ
TDEVHH-TQLKELFGLEPEYVTAML-GHLKPRLHPDDLPLLKRALVEH-LKGEDYQVEYRVRHGDGHWVWIEDRGRAVRAASGRVIRMLGTRRDISAGKA
LEEQQRLASTVFEAASEGIVILDPDYALIAVNQAFSRVTGFDIDDMLGRNVVELPSSRDARRHFPVIRQALLSHGTWQGELVETRKNGELYPQWLQLNVV
RDVRGKVSHIVGFFADLSARRESEERMRYLTHYDELTGLANRSLFRERLREAHQRVRQGGRSLALLHINLDRFKLLNDSLGHEVADQLLQKMARRLINAL
PEADTIARLSGDEFAVLFDAYGSSSLARVATRLLAKLRVPVTVEGHELVVSASMGVSLLPDNAREISELVNQSNMAMQHAKHLGGNNFQFYTDSLQGSTL
ERLQLENHLRKAIEERQLSVFYQPKLCLATGRLNAAEALVRWEHPQWGMVPPCDFIGLAEETGLIVPLGEFVLREACWQACEWQRQGLASIRVSVNLSVH
QLRQGKLVSLVRQVLEETGLDPQYLELELTESQLLDSVEHIIATFQQLRDLGVKLAIDDFGTGYSSLSYLKRIPVDYVKIDQTFIRGLGQGREDAAITRA
IIAMAHGLALKVVAEGVEDQQQLDFLRAERCDEVQGYLISRPMQADGLAELLRKNA----
>tr|F2K755|F2K755_PSEBN Putative diguanylate cyclase/phosphodiesterase OS=Pseudomonas brassicacearum (strain NFM421) GN=PSEBR_a5596 PE=4 SV=1
-----------------------------------------------------------------------ASQALSKSEARLALALKASELGLWDWNLQ
TDEVHH-TQLKELFGLEPEYITAML-THLTPRLHPQDLPALKRALVEH-LKGEDYQIEYRVRHGDGHWVWIEDRGRAVRSVSGRVLRMVGTRRDISASKE
LEQQRQLAATVFEAASEGIVIFDPHYVLLAANQAFTRVTGFNIDEMLGRNVVDLPCSRDARRHYPIIRQALKQHGTWQGELVEARANGELYPQWLQLNVV
RNARGNVSHIVGFFADLSARRESEERMRYLTHYDELTGLANRSLFRERLHEAHQRVRQGGRSLALLHINLDRFKLLNDSLGHDIADQLLQKMARRLINAL
PEADTIARLSGDEFAVLFDAYGNSSLARVATRLAAKLRVPLTIEGHELVLSASIGISLLPDNTREVAMLVSQANMAMQHAKHLGGNNFQFYTDSLQASTL
ERLQLENQLRKALEEQQLKVFYQPKLCLATGRLNAAEALVRWDHPAMGRVPPGDFIGLAEETGLIGPIGEFVLRQACWQACEWQRQGLAPIRVSVNLSVH
QLRQGKLVSLVRQVLEETGLDPQYLELELTESQLLDSVEHIIATFQQLRDLGVKLAIDDFGTGYSSLSYLKRIPVDYVKIDQAFIRGLGEGSVDAAITRA
IIAMAHGLSLKVVAEGVERQEQLEFLRNERCDEVQGYLISRPVEAEGLAGLLRAQH----
>tr|A0A0E1ECX0|A0A0E1ECX0_9PSED Diguanylate cyclase OS=Pseudomonas chlororaphis GN=EY04_29865 PE=4 SV=1
-----------------------------------------------------------------------ANQALSKSEARLALALKASQLGLWDWNLQ
TDEVHH-SHIKELFGLEPEFVRAML-SHLKPLLHPEDLPLLKRALVEH-LKGEDYLVEYRVRHGDGHWVWIEDRGRAVRGPGGRVLRMVGTRRDISASKQ
QEEQRRLSAMVFEAASEGIVILDPDYVLLAINQAFSRVTGYQIEDMLGRNVVDLPCSRDARRHYPVIHQALEQHGSWQGELVEARKNGELYPQWLQLNVV
RDTRGNISHIVGFFADLSARRESEERMRYLTHYDELTGLANRSLFRERLREAHQRMRQGGRSLALVHINLDRFKLLNDSLGHDVADQLLQKMARRLVNAL
PEADTIARLSGDEFAVLFDAYGSSSLTRVATRLSAKLRLPIPVEGHELVVSASMGISMLPDSAREIPALISQANIAMQHAKHLGGNNFQFYTASLQASTL
ERLQLENQLRKAVEERQLKVFYQPKLCLATGRLNAAEALVRWDHPDLGRVPPGDFIGLAEEIGLIGPIGEFVLRQACWQACEWQRQGLPAIRVSVNLSVH
QLRQGKLVSLVRSVLEETGLAPHFLELELTESHLLDSVEHIVSTFQQLRDLGVKLAIDDFGTGYSSLSYLKRIPVDYVKIDQAFIRGLSEGGADAAITRA
IIAMAHGLSLKVVAEGVEHPGQLAFLKEQKCDEVQGYLISRPVEAEGLAALLRAET----
>tr|A0A067ABV2|A0A067ABV2_9PSED Diguanylate cyclase domain protein OS=Pseudomonas sp. P482 GN=BV82_2243 PE=4 SV=1
-----------------------------------------------------------------------ANQALSKSEQRLALALEASELGLWDWNLE
TDEIHH-TQLRELFGLEPDQVQEML-AHLKPRLHPDDVPLLKRTLVEH-LKGEDYRIDYRVRHRQGHWCWIEDRGRAVRSASGRVLRMLGTRRDISAQKA
QEEQQRMAATVFEAASEGIVILDPDYVLLAVNQAFCRVTGYNREELLQGRLLELPCSRDARRHSQAIELALEQQGNWQGELVEARKNGELYPQWLQLNGV
RDARGNLTSIVGFFTDLSARRESEERLRYLAHYDELTGLANRALFRLRLHEAGERLRQSGRGLALLHIDLDRFKLLNDSLGHEVADQLLKQMAQRISNAM
PEADTVARLSGDEFAVLFDAYSNSSLVRVASRLLDKLRVPLRVDGHELVISASVGISLLADTSRDVTVLVSQANTAMQHAKHLGGDNFQFYTESLQASTL
QRLQLENHLRKAIEERQLQVYYQPKLCLATGRLHAAEALVRWQHPQWGMVPPSDFIGLAEETGLIAPMGEFVLRQACWQACEWQRMGLAPIRVSVNLSVY
QLRHGKLVSLVRQVLDESGLAPHLLELELTESQLLDSVEHIIATFRQLHELGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQAFIRGLSEGSEDAAITRA
IIAMAQSLDLQVVAEGVETHEQLEFLRKQGCNEVQGYLISRPVPAQELAELLASHY----
>tr|A0A077FJS1|A0A077FJS1_9PSED PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Pseudomonas alkylphenolia GN=PSAKL28_52190 PE=4 SV=1
-----------------------------------------------------------------------ANHALSKSEQRLALALEASELGLWDWNLE
TDEVHH-TQLRELFGLEPAQVRSVR-NDLKPRLHPDDLPLLRRTLVEH-LKGEDYRVEYRVRHSQGHWCWIEDRGRAVHGANGKVVRMLGTRRDVSAQKA
QEEQQRLAATVFEAASEGIAILDPDFVLLAVNQAYCEVTGYSREELLSRNALELPSSRDARRHSLAIEQALDQQGRWQGELVEARKNGDLYPQWLQLNGV
RDARGTISNIVGFYTDLSARRESEERLRYLAHYDELTGLANRALFRLRLHDAGQRVRLNGRSLALLHIDLDRFKLLNESLGHELADQLLKKMAQRIANAV
PEADTVARLSGDEFAVLFDGYNNSSLVRVTTRLLDKLRVPQRLDGHEVVISASVGISLLSDATFDLGALVSQADMAKQHAKHLGGDSFQFYTENLRASTL
ERLQLENHLRKAIEERQLLVYYQPKLCLRQGRLLAAEALVRWQHPQWGMVPPSEFIGLAEETGMIAPIGEFVLRQACWQACEWQRQGLAPIRVSVNLSVY
QLRQGKLVSLVRQVLEESGLAPHLLELELTESQLLDSVEHIITTFQQLHELGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQAFIRGLHEGSEDAAITRA
IIAMAKSLDLKVVAEGVETPEQLALLREQGCDEVQGYLISKPVDASAFGALLERSM----
>tr|Q1I2M4|Q1I2M4_PSEE4 Pseudomonas entomophila str. L48 chromosome,complete sequence OS=Pseudomonas entomophila (strain L48) GN=PSEEN5503 PE=4 SV=1
-----------------------------------------------------------------------ANQALSKSEERLALALEASELGLWDWNLQ
TDEVHH-TQLQTLFGLDSDQVRSVR-ADLKPRLHPDDLPLLRRTLVEH-LKGEDYRVEYRIRHVQGHWCWIEDRGRAVRSSDGKVTRMLGTRRDITARKE
QEEQQRLAATVFEAASEGIAILGADYQLLAVNQAFCDVTGYGRAELIARNALELPCSRDARRHSQAIDQALEQHGGWQGELVEARKNGELYPQWLQLNSV
RDARGRIVNIVGFFTDLSARRESEERLRYLAHYDDLTGLANRALFRLRLHDAAQRLRLNGRSLALLHVDLDRFKLLNESLGHELADELLKKMAQRIANAV
PEADTVARLSGDEFAILFDGYTNSSLVRVTTRLLDKLRVPQRLGGHELVVSASVGISVLADASFDINALVSQADMAKQHAKHLGGDNFQFYTESLRASTL
ERLQLENQLRKAIDEGQLLVYYQPKLCLRTGQLHAAEALVRWQHPQWGMVPPGEFIGLAEETGLIAPMGEFVLRQACWQACEWLRQGLE-VRVSVNLSVY
QLRQGKLVSLVRQVLQESGLAPHLLELELTESQLLDSVEHIIATFEQLHALGVKLAIDDFGTGYSSLSYLKRFPVDYVKIDQAFIRGLLEGSQDAAITRA
IIAMAKSLQLKVVAEGVETLEQLAFLREHGCDEVQGYLISRPVDADAFQALLERPT----
>tr|A0A099RNG5|A0A099RNG5_9PSED Diguanylate cyclase OS=Pseudomonas sp. HMP271 GN=DP64_15550 PE=4 SV=1
-----------------------------------------------------------------------VADELRQSEARLSLALEASELGLWDWDLA
LGKVHY-SRLEVSFELDARQRPDAE-GRPLPDLHPDDLPGVRAKLIAH-LKGELYAVEYRALRADGSHLWVEDRGRVIRDADGRALRMLGTRRDISDLRR
QAEQQRLAATVFEAAGEGMVIMDSRFRILAINDACCALSGFSREELLGRSAARLAGSAESQRRYAAMREALQRDGSWQGELLEVRKNGEVYPQWLQLREV
RDALGGISHVVGFLSDLTVRRQAEERLRYLMHYDNLTGLANRSLLKERLHAACLRAQQSGRTLAVLYIDLDRFKNLNESLGHEAADRLLGEMSRRISQTL
AEADTIARLSGDEFVVLLEGYGSSSLAHLGSRLLTRVRKPVTVAGEELVISASIGVSLMPDNSRDAVTLLRQASRAMQQAKHLGGNTLQFFTERAQRATI
DYLQMENQLRKALVEGQLEVFYQPRLTLLDDRLEAAEALVRWRHPQQGLVAPAQFIPLAEETGLIIPLGEFVLREACRQAREWQRSGLADIRISVNLSVK
QLRQGNFVSLVRQVLEETGLPASMLELELTESQLLDDIDNAINISRQLRALGIKLAIDDFGTGYSSLSYLKRFPVDYVKIDRTFICELEHSAEDAAIVRA
IIAMAHNLELQVVAEGVETQAQMDFLKDQRCDEIQGYLVSRPVPAAQLAELLG-------
>tr|A0A031MDL5|A0A031MDL5_9PSED Diguanylate cyclase OS=Pseudomonas bauzanensis GN=CF98_25910 PE=4 SV=1
----------------------------------------------------------------------------QQTQARLSMALEASALGLWDWDLR
TDEVHH-SHLQEIFGLPDT-RLTMQ-GGLKPRVHPEDVERVRAALIAH-FKHTPYCVEYRVKHQAGHWVWVEDNGRAVRDSARRALRMIGTRRDITSRRQ
HHERERLAATVFEATSDGIFVLDPQRRILAVNQAFSVITGYAANDVVGKALTSASTNPDTLATYARMRTTLLSHDRWEGEVQEQRRSGERYLQWLQLTVV
RNGAGDITHYVGFFADRTINRQTEEQLRYLANHDSLTQLANRGLFTRTLAEATGQARAHGTGLALLHIDLDRFKNINETLGHAQADALLRQVADRLSATL
SDALILARLSADEFVVVQQDMP-SALEQLASRLLQILGEPIRLGDNDLIISASIGISLFPGEARNSLQLINQANQAMQHAKHLGGNGFQFYSAQLPTRST
DRLHLENDLRKALTDDQLQVHYQPKLHLASNSINSAEALVRWQHPTRGMLLPGEFIAIAEETGLILPLGEKVLRRACIQASQWLHTGPLAVRVAVNLSVQ
QLRQPHFAALVANILTDTGLPSHLLELELTESMLLEHSDSVADNLAALRQLGVELAVDDFGTGYSSLAYLKRFPIRCLKIDRAFICELDEQPGDTAIVRA
IIAMAHSMHMSVVAEGVEQESQLAFLRSQGCDEVQGYLISKPLPTDAFTRLLQQQQ----
>tr|A0A078MB05|A0A078MB05_9PSED PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. 12M76_air GN=BN1049_01630 PE=4 SV=1
----------------------------------------------------------------------------QQTQARLSMALEASALGLWDWDLR
TDEVHH-SHLQEIFGLPDT-PLTMR-GGLRPRVHPEDTQRVRSALIQH-FQQTPYCVEYRVRHRDGHWVWVEDNGRAIRDSAGRVLRMIGTRRDITERRH
RHEQERLAATVFEATSDGIFILDPERRILAVNQAFSVITGYPARDVIGRVLTSASTDPDTQATYARMGTALRHHDRWEGEVLEQRRSGERYPQWLQLTVV
RNPAGEITHIVGFFADRTINHRAEEQLRYLTDYDSLTQLANRSLFSRKLAEATSQARARGNELALLHIDLDRFKNINETLGHVQADALLRQVAERLAAQL
PQAVVLARLSADEFVAVKQNLP-HALAQLATRLLQVLGEPIRIGDNELIISASIGISLFPREATNSLQLINQANQAMQHAKNLGGNGFQFHSADLPTRSA
DRLHLEHELRRAIADGQLQIHYQPKQQLASNRIDSAEALVRWQHPTRGAMLPGDFISIAEETGLILPLGDQVLRRACAQASQWLREGPQAVRVAVNLSGQ
QLRQPQFAAAVERILDETGLPGHLLELELTESMLLEHSEGVADNLAALRQLGVELSVDDFGTGYSSLAYLKRFPIRCLKIDRAFICELHEQPGDIAIVRA
IIAMAHSMNLRVVAEGVEHDSQLAFLRSLGCDEVQGFLISRPLPAADFARLMALQV----
>tr|I3CIY8|I3CIY8_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Beggiatoa alba B18LD GN=BegalDRAFT_2746 PE=4 SV=1
-----------------------------------------------------------------------ERSSLLRESNRLNTLLMGIRGVVWEVNPA
TKRVTYIPFVEKLLGFAPEQ-CLKK-GFLLHRVHADERQQLRDISLGH-IAEDTFMFDYRVLNGQGEWLWLRNIGM-VRDKARNSLNVLGIVWDISENKQ
LLEQVHQAKIVFDNTNEGIIITDAQRRITSINKACCDITGYQSDELIGQTPHILYSGQQDNEFYAQLWHALNTTGRWQGEIWNKHKNGQIYPSWESISVV
RNEYNEIIHYIAVFSDISTIKNAERQLEHLAHHDLLTDLPNRLFFNLRLEQALSYAQQTREEVAILFLDLDRFKNVNDTLGHLVGDQVLQTVSRRLKACL
RPQDTLARLGGDEFILLITGTPDHKTIAIAQRLLHAIQQVILINPHEIVVTGSVGISIYPCDGTDAQALVKYADVAMYRAKSLGNNQYCFYTSQLTTEIE
RRFSLENELRHAIEQEKLQLYYQPKVDLMTGRIIGAEALLRWEHPQQGFISPEIFIPLAIETGLINSIDRWVLFQACQQMQRWQVEQGYHVSIAVNLSNF
-INHDSLLVVLKRCLKQTQIDPVYLELEITEGFVMQNTESVMENLNAIKQLGVRLSIDDFGTGYSSLSYLKRLPLDTLKIDRSFIRDIPDDTDDTAIVQT
IINLAHNLNLSVIAEGIENQAQLAFLQQHDCDEGQGYLFSKAVPADEFVQLLQDSY----
>tr|C6E953|C6E953_GEOSM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Geobacter sp. (strain M21
---------------------------------------------------------------------SEQVERIRRREQQLSQAERITHLGSWEWNLE
SGETVWSDELYRILGLEPESVAATFES-LLRMVHPADRETMEKAVQQLRETGSALGIQYYLLRADGETRIVRGQEACLTERSAELPYLLTLFKDISERKR
LEEDRARLAAIVESSDDAIMAVDREGAITSWNAGAEKMFGYCAQDMKGVHLL-VSPEKKEQ-----V-TCLN-DGVTHCEVVHVTRGGSQIYVSLTMSPI
KSADGGIVGTSCIARDVTERTRMEEIIKHQAQHDTLTDLPNRKLFGDFLNLELAQARRNRKSLAVLFMDLDHFKKVNDSLGHAAGDRLLQAVAQRLKRCV
RESDTVARISGDEFNVLMPDLTQDDVGIVVGKIMGVFRTPFVLEGAELKVTTSVGVSMFPDDGDSAQELLQKADGAMYVAKQTPGNSYQFYNGEINARTV
ARQNMERRLREAVSKDELDLVYQPLLSLESGEIVGAEALLRWHHPEHGLLLPAQFLPVAEETGAIVPIGEWVLFNACRQMRLWQSQGF-DLSVAVNLSNR
EFHQPNFIDLAMRALSQSGLDPASLELDVTEKAIMDNPAFSLRNMRRLTDIGVAFSVDDFGVGASSLSRIKELPIAKVKIDRSFIRDILTEPNDLDVVSA
VICMSHSLKMRVNAVGVESAEQLALVGSFGCDEVQGDLISRPLPPHEFERLLVEGG----
>tr|T2J983|T2J983_CROWT COG0642: Signal transduction histidine kinase OS=Crocosphaera watsonii WH 0401 GN=CWATWH0401_2890 PE=4 SV=1
---------------------------------------------------------------------AQRTAQLSQLAEQATQALKFSQTGSWEFDVV
-EKVFWSEEVERIWGMEPGTFRGE-LQ-VQGAIHPEDVEHWQKNVQDCREKGKEHRIEYRIIHPDASIHWVQALSIVTFNRDGQFKGYIGSVMDISDRKR
MEEQLRIFE-IVATTQDMMALIDQNYTYQIVNDAYARNFQRAKEEIIGKSVVEIVGHLQGEEVRYETW----------------------YYHAL-YSRY
REANKGVTSAVVNIHDITQIKESEQKLYYQAHHDTLTNLPNRMLMNTRLEQSIQQATRKGDKLAVVFIDLDRFKNINDSLGHRAGDSLLEQLAQRLCQQR
RKSDTVARISGDEFVVILEDIKDQHAGMVVGKLMRTFEEPFIIEGRTIKMTSSMGLSLFPDDGTDVATLLRNADAAMYRAKEDGRNTYCFYRKEMTSTVF
EYMLLENALREALKKKEFYLLYQPQIEMLSHRCLGIEALLRWHHPELVVVSPAQFIPIAEQSGLIQEIGTWVLTTACRQAKIWLEQKLDFGRIAVNVAAP
QIQHGDFIQVVENVLKTTGLPAAYLELELTEGLLMKQTEQNIKQLEKLQGMGIKLTIDDFGIGYSSLNYLKRLPIDKLKIDQSFIRDLPHDTNDTAISQA
VIALGYALNLQIIAEGVENEEQAAFLKEKGCHQAQGYFFSQPIPPQQVSALFA-------
>tr|B8KF61|B8KF61_9GAMM Ggef/eal/pas/pac-domain containing protein OS=gamma proteobacterium NOR5-3 GN=NOR53_1428 PE=4 SV=1
---------------------------------------------------------------------GISTWRWE----EFQDGIRMLQVRDDELPLS
-DTILGQVVNEDVAGFEAA---------MARLI--------------TEPEGKAQEVDFRADLDSGEQRWFRAIRVLKKSK---DSIICAVGRDISKENA
AKQGLFQAA-VFKNSGEGILISDEKGLIRDVNAAFSQITGYSRDEAIGQATSLLRSGRHDAEFYKKMW-----------EIWNRRKSGAVFPELLTISKI
DG---QNSGFVAIFTDITQLKETEEQLQKLAHYDPLTELPNRYLINERLQQSIRRAQRRSERLAVFFLDIDSFKNINDSLGHLAGDKLLAMTANRLRELL
RDDDTVGRIGGDEFLMLLEDINSDVATNIAEKIIGALRKPTILEGRSVSVSASVGISIYPDDGQTAETLMSNADAAMYSAKEQGRNTFRFYSENLTRAAF
QNVLIDSALREAKSRNEFRLAFQPQIDIVTNSLLGLEVLLRWHHPTLGTVSPAQFIPQAERTGLIRDIGQWVLEQACLQGNKWLAEGLPFGRLAVNVSAP
QFRAEDFVDQVRQVLEYANFPPNRLELELTESVLVQDTEQLIGNMDELRAMGIQFAIDDFGTGYSSLSYLKKMPIDRLKLDKSFVDNISTDDNDRIIAEA
VVALGQAMGLEVIAEGIEYEEQARALRDIGCTQFQGFLYGMPMYTSRIEGVLRKEA----
>tr|A0A021VYD1|A0A021VYD1_9CELL Diguanylate phosphodiesterase OS=Actinotalea ferrariae CF5-4 GN=N866_18810 PE=4 SV=1
---------------------------------------------------------------------PHL-DDTRRALERLHEAQRIGQIGDWGFDLA
DGVISWSPQVYEIMGLDPTLDPPALAD-MLELFEPDSAAALRHHIDLAVRTGEAQE--YGLVLVRGGVHL---Q-TI---PTGEPYRVAGIQVDVTERRR
EVEAAIRLA-IVQSSEDAIISQDRAGVVLSWNPGAERLFGHAAAQMIGRGLDLADS-----GAPEQRW-------VAPFESLRRRADGVLIDVVLTLSPL
KDKDGRVVGVSTIARDIGERKRLELSLRHLALHDTLTGLPNRALLDDRMQHALTANRSRDNTVSVLFLDLDRFKVLNDAEGHAAGDAVLVEVARRLCAAV
RPHDTVARFGGDEFVVLCESGGL-TARLVAERLHASLAQPFLTEGQTRFLAASIGIAVADDDS-TAEELLRDADAAMYRAKDLGRGRTAVFDPDIRARAA
ARLEATTALRRALGAGELRVYYQPVVDLSDESLLGFEALVRWQHPELGLLGPGAFVPEAEESGFVVPLGEWVLDTALEQSRRWAMTWAAPPHVAVNVSAR
QLEEPDLAQVVANALTRHAFPAEALTLEITESAVMRDVLRNVENLRALRDTGLELSIDDFGTGYSSLVYLKRLPVTSLKIDREFVDGLGREAHDSAIVTA
VVALARALELRVIAEGVETPSQLAELRRLGCDAAQGFFFSPPIPAEEAEQWVRCGR----
>tr|I3IR17|I3IR17_9PLAN Diguanylate cyclase/phosphodiesterase OS=planctomycete KSU-1 GN=KSU1_D0853 PE=4 SV=1
---------------------------------------------------------------------KEAEEALRKSEASLANAQRIAHLGNWQWNMR
ENKTYWSDEMYRIFGFAPQTIDGVCEA-YLNSVHPDDRVLVKQSLDEALSRGKPYRIEHRIVLPGGSVRIVHGQEIVEKTKDGVITNFIAIKEDITDRKK
VERHLCLQYA-----VESIAI---DEVIPKIIQAVCESLGWDI--------GIWTIDQKTNVLRTRNEI---G--VGFIGFDNALTTGSRYEEDLALLR-
--------ITAEIIGNAIARRQSESLINHMAYHDALTNLPNRILLQDRLEVAIMQAKRNEHMVAVMLLDLDRFKTINDTLGHHMGDLLLKAVAERLTRCM
RESNTIVRMGGDEFIVVVPDLAHKNAAIVAQKILDVLYQPFQIEGYEIHTTTSIGVSIYPIDADDASMLIKKADTAMYHAKEQGRNTFEFYMESMNSNNF
ERMMLENSLRKVLERGELSIYYQPQVDMDTEQIIGVEALVRWKHPDLGMIYPSKFIPIAEETGFIIPIGEWVLTTACTQAKAWHNAGFPTLRVSVNLSAR
QIKQQNLVGMVAGVLKETGLDPKYLELEITESIVMHNIESSLKVLCELKELGIRLSIDDFGMGYSSLSYLRRFSIDTIKIDQSFVRDITTNQDDAAIVTA
IIAIAESLKLKVIAEGVENKEQLAFLHQICCNEIQGYIYSHPLSAVDMGKLLLKKY----
>tr|Q1NRJ4|Q1NRJ4_9DELT PAS:GGDEF:EAL:GAF OS=delta proteobacterium MLMS-1 GN=MldDRAFT_4300 PE=4 SV=1
---------------------------------------------------------------------RRVQQELMVSSSQLRKAQQIAKMGHWEWKHD
DQPLHWSAELYRIFGQDPESYTPDYQA-FLATIPEDDRRQVQEAVAHTQREGVPYDITHRIRLPNGREKIIHERETAMRLKG---GGIICYARDITERQK
REERMRLSSRFLEDTNEAVVITDADARIIEVNRAFEKLTGYSRQEAIGQNPRILQSGHYDADFYREMW-----------ELWSRRKNNELHPKWLSISAV
YDQRGRITHYVGISNDLTATKQTQEKLEELTHYDQLTSLPNILLFRDRLQQAMARARREEHKVALLIFDLDRFKEVNDSLGHSVGDLVLTEVAQRLRQQL
SLADTICRPGGDEFYLLLGRLTDDTAVQAAQNVLELFSKPFQAADHQLYLTPSIGITLFPDDGEEVESLIQSVETAMYHAKKDGGNSFQFFQETMFTAAL
GRMTMKNRLRRAVELEEFELYYQPKIAADGRTVVGAEALIRWVQPERGPVSPAEFIPLAEETGLIIPIGEWVLRQACRQSLLWQQAGLPPLRIAVNLSAV
QFKQPGLDDEINWILQEIGLPAELLELEITESLLMEDVTTANATLWKLKDMGIHLALDDFGTGYSSLSYLKNFPLDTLKIDREFVRDLSTDDEDRAVIIT
IITLAHSLKMEVVAEGVEDADQVAFLRQRGCDVFQGYHFSRPLPAKEFEQFLRSQN----
>tr|A0A080M0H8|A0A080M0H8_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-91 GN=gmr_1 PE=4 SV=1
---------------------------------------------------------------------QAREADF------------------------
----------------------------------------------------------------------------EVTQHAGQVVRIVVVSHDITDRKQ
AEQWERIAA-TAFESQQGMFITDAAGVILRVNQAFTEITGYSAEECVGQTPKLLSSGRHNAAFYAAMR----ESG----EIWNRRKNAEIFPEWLTISAV
IDNEGRVTHYVSTLTDISLRKAAQEEIQQLAFYDALTRLPNRRLLHERLQAAMAASARSGRQGALLFIDLDNFKTLNDTLGHDMGDHLLQQVAKRLLTCV
RDRDTVARLGGDEFVVMLASLGAAQSRIVGEKILAALNRPYDLAGSEYHNTPSIGITLFGGQHDAIDELMKRADLAMYDAKATGRNTLRFFDPQMQAVVT
ARAALERDLREALQKQEFFLCYQPQVDQ-AGRIVGAEALLRWRHQQRGLVTPAEFIPLAEETGLILPLGLWVLETACAQSAVWAAQAGRNFTVSVNVSAR
QLCQPNFVEQVLGVLASTAVNPHNLKLELTESMLLDNVQEIIAKMTALKERGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDLLTDPNDEAIART
IVALASNLGLEVIAEGVESVEQRDALAAQGCHTYQGYLFSRPLPLADFEVFLQSSH----
>tr|E6QPT2|E6QPT2_9ZZZZ Uncharacterized protein OS=mine drainage metagenome GN=CARN7_2921 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------LNPLFKDKVPNSFWEVIDP----------IALTIDQLKQEIGQRKGLVIIGRDITERKR
TEQELRIAA-IAFETQEGILITDRDERILRVNHAFTRLTGYSAEEAIGRTPAMLQSGRQDAAFYHSLW----TDK----EIWNRHKDGVVCPEWLTVTAV
TDADGQVTHYVAMFSDLTLRKAADEKIYQLVFYDALTNLPNRRLLMDRLQHAFSAGARNGQHGALLFLDLDHFKILNDTKGYDSGDLLLIEVAKRLQDCM
RSSDTVARLGGDEFIVMFNELSAAQAHAVGERVLASINQPFNLQGFEHHCSVSIGISLFRGDEIGADDLLKQADIAMYQAKTAGRNTLRFFDPAMQAALE
IRAELESELRQALEKQQFRLHYQIQVDS-LHRPLGAEVLLRWEHPERGMVSPMQFIPLTEETGLIVPIGLWVLQTACAQLNAWQHDALTDLILAVNVSAR
QFRQPDFVAQVQRVLVESGAPPSHLKLELTESIVLENIEDIITKMSTLKLLGVSFSMDDFGTGYSSLQYLKRLPLDQIKIDQSFVRDISTDPNDAAIVQT
IIAMTDALGLNVIAEGVETEAQSVFLHKHGCHAFQGYLFSKPVPVNEFEQLIAQYA----
>tr|M4WZG9|M4WZG9_PSEDE PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas denitrificans ATCC 13867 GN=H681_16730 PE=4 SV=1
---------------------------------------------------------------------RDSQERLD-------LALDSAQLGIWDWHIP
SGMLYGSIRAAVLHELPAQDFHGPFGE-FFACVDETDRRRMRQAYARLAKPDNDYQFTYRAQLQSGEVRYLESRRTLIHMRASRLLCILSTFRDVTRRQQ
AEAELKASQEAFHSSPDAITIERDSGRYIEVNEGFHRLTGYRPEEVTGHTSLNWGD-------------------VHHLEMCGRHRDGHTKTVDVSVEPI
DLG--GTACLLLTARDTSELREAEARIQHLAYHDALTDLPNRALLMDRLKQQIALLQRHNLRGALLFLDLDHFKHINDSLGHSVGDAILQMVTARLEASV
RQEDTVARLGGDEFVILLTGIDGRRVRQLAEKLRDLLAEPMLLDGHRLQITPSIGIALIPDDGATPEDLLKRADIAMYRAKDAGRNTVQLFHASMQKAAS
ERLRLESGLRMAIARREFSLHYQPQIDSRGGRIVGAEALLRWEHPTQGAQSPASFIRVLEDSGLIIAVGHWVIEEACHTCARLLAEGRIDFCLSVNISPR
QFRQSDFVERVLDSLDKAGLPARLLKLEITEGIVIQQLEDTIARMQRLRQAGVRFAMDDFGTGYSSLTYLKRLPVDSLKIDQSFVRDAPNDSNDAEIVRA
IIAMGHSLGLELIAEGVETPEQLALLEEQGCHLHQGYLFSRPVPLEAFIDLLPPRD----
>tr|L1LWV5|L1LWV5_PSEPU PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas putida CSV86 GN=CSV86_20149 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALDSAQLGTWDWHIP
SGMLYGSARAAQLHGLDPVPFHESFEA-FFEGVPEDERSSMRQAYRSLREPAGNYQITYRIQLENGNSRYLESRRTLIHIKSSRLTCSVTTLRDITQQQR
AEAALKASEEAFHSSPDAISIELQTGRYLEVNDGFCRLTGYSAGEVLGRTAIGWAD-------------------VHHREMLGRSKSGELLTLEVSVEPI
TLN--ETACLLLTARDVSQLKNAQAQIRHLAYHDPLTNLPNRALLMDRLSQQIALLKRHNLRGALLFLDLDHFKHINDSLGHPVGDTVLKIITARLEASV
RLEDTVARLGGDEFVVLLSGLQGRQVQELADTLRQLLAEPMSLDGQRLQVTPSIGVALIPDHGSTPADLLKRADIALYRAKDSGRNTTQLFHTTMQKAAS
ERLRMESDLRLALTRGELALHFQPQVDARDNRIVGAEVLLRWHHPLLGQQPPAQFIQVLEESGLILEVGNWILDEACDACSHMLQDRLIDFSLCVNISPR
QFRQNDFVQRVRRSLDDYRLPYRMLKLEITEGIVIQNLEDTISKMRELKALGVGFAMDDFGTGYSSLTYLKRLPVDTLKIDQSFVRDAPLDSNDAEIVRA
IVAMARSLDLTVIAEGVELSEQLEFLERQGCFLYQGYLHSRPLPLGDFRAILLETP----
>tr|A0A084CAA3|A0A084CAA3_9PSED Histidine kinase OS=Pseudomonas sp. WCS358 GN=PC358_13780 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALDSAQLGTWDWHIP
SGMLYGSARAAQLHGLDPIPFHESFDA-FFEGVPEQERNVMRQAYRSLREPAGNYQITYRVQLDNGTSRYIESRRTLIHIRSSCLPCSVTTLRDITQQQR
AEAALKSSEEAFHSSPDAITIERYSGRYLEINDGFCRLTGYSAAEVVGRSVLGWAD-------------------VHHREMLGRNKRGDILTVEVSVEPI
TLN--ETDCLLLTARDVSQLKNAQAQIRHLAYHDPLTNLPNRALLMDRLSQQIALLKRHNLRGALLFLDLDHFKHINDSLGHPVGDAVLKIITARLEASV
RLEDTVARLGGDEFVVLLSGLEGRKVRDLADTLRELLAEPMSLDGQRLQVTPSIGVALIPDHGTTPADLLKRADIALYRAKDSGRNTTQLFHTTMQKAAS
ERLRMENDLRLALARGELALHFQPQVDARDNRIVGAEVLLRWHHPQLGQQPPAQFIQVLEESGLILEVGSWILDEACDACAHMLMDGLIDFSLCVNISPR
QFRQNDFVGRVLRSLDDYRLPRQMLKLEITEGIVIQNLEDTISKMRELKRHGVSFAMDDFGTGYSSLTYLKRLPVDALKIDQTFVRDAPIDPNDAEIVRA
IVAMAHSLDLAVIAEGVELTEQLAFLEQLGCHLYQGYLHSRPLPLSEFRQMLLEAP----
>tr|I4MVL8|I4MVL8_9PSED Sensory box protein OS=Pseudomonas sp. M47T1 GN=PMM47T1_27955 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALDSAQLGTWDWHIP
SGMLYGSARAAQLHGLEPVPFHESFEA-FFEGVPDEERNTMRQAYRSLREPAGNYQITYRIALENGTSRYIESRRTLINIKSSRLPCVVTTLRDITQQQR
AEAALKSSEEAFHSSPDAITIERDSGRYLEVNDGFCRLTGYSVNEVLGRSVIGWAD-------------------LHHRELIGRNKRGEALTLEVSVEPI
TLN--ETPCLLLNARDVSQLKNAQAQIRHLAYHDPLTNLPNRALLMDRLSQQIALLKRHNLRGALLFLDLDHFKHINDSLGHPVGDTVLKIITARLEASV
RLEDTVARLGGDEFVVLLTGLEGRQVRELADTLRALLAEPMSLDGQRLQVTPSIGVALIPDHGTTPADLLKRADIALYKAKDSGRNTTQMFHNTMQKAAS
ERLQMENDLRMALARGELSLHFQPQVDAREDRIVGAEVLLRWHHPLLGQQSPAQFIQVLEESGLILEVGSWILDEACGACAQLLREGLIDFALCVNISPR
QFRQNDFVQRVERSLSQNNLPCTLLKLEITEGIVIQNLEDTINKMRSLKKLGVSFAMDDFGTGYSSLTYLKRLPVDALKIDQSFVRDAPQDPNDAEIVRA
IVAMARSLELTVIAEGVELSEQLEFLERLGCHLYQGYLHSRPLPLAQFRQMLIDEI----
>tr|A0A0A7JII9|A0A0A7JII9_9PSED Histidine kinase OS=Pseudomonas parafulva GN=NJ69_03870 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALDSAQLGTWDWHIP
SGMLYGSARAAQLHGLDPAPFHESFDA-FFEGVPEEERSAMRQAYRSLREPAGNYQITYRVQLENGASRYIESRRTLIRILSSRLPCSVTTLRDITQQQR
AESALKASEEAFHSSPDAITIERQSGRYLEVNDGFCRLTGFSSHEVVGRTVLGWTD-------------------VHHREMLGHNKQGEVLTVEVSVEPI
SLN--DTDCLLMTARDVSQLKNAQAQIRHLAYHDPLTNLPNRALLTDRLSQQIALLKRHDLRGALLFLDLDHFKHINDSLGHPVGDTVLKIITARLEASV
RLEDTVARLGGDEFVVLLSGLAGRQVRELADTLRELLAAPMSLDGQRLQVTPSIGVALIPDHGSTPADLLKRADIALYRAKDSGRNTTQLFHTTMQEAAS
ERLRMENDLRLALSRDELALHFQPQVDARANRIVGVEVLLRWHHPQLGQQSPALFIQVLEESGLILEVGSWILDQACEACARLLDEGLIEFSLCVNISPK
QFRQNDFVERVLRSLDEHHLPRYMLKLEITEGIVIQNLEDTIGKMRELKRHGVTFAMDDFGTGYSSLTYLKRLPVDALKIDQTFVRDAPNDSNDAEIVRA
IVAMAHSLGLTVIAEGVELTEQLTFLQRQGCHLYQGYLFSRPLALAEFRRLLAETS----
>tr|A0A089WY29|A0A089WY29_9PSED Histidine kinase OS=Pseudomonas cremoricolorata GN=LK03_20795 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALDSAQLGTWDWHIP
SGMLYGSARAAQLHGLAPEPFHESFEA-FFEGVPRQDREVMRQAYRSLRQPAGNYQITYRVQLDNGGSRYIESRRTLIRLRSSRLPCSVTTLRDITHQQR
AEAALKASEEAFHSSPDAITIECESGRYVEVNDGFCRLTGYSASEVVGRTALGWAE-------------------VHHREMLGRNKRGDLLTVEVSVEPI
NLN--DTDCLLVTARDVSLLRDAQAQIRHLAYHDPLTNLPNRALLMDRLSRQIGLIRQQNLRGALLFLDLDHFKHINDSLGHPVGDTVLKIVTARLEASV
RLEDTVARLGGDEFVVLLGGLEGRQVGEVADTLRELLAQPMSLDGQRLQVTPSIGMALIPDHGATPADLLKRADIALYRAKDSGRNVTQMFHSSMQTAAS
ERLRMENDLRMALARGELELHFQPQVDARDSRIIGAEVLLRWHHPQLGQQPPAQFIQVLEESGLIIEVGSWILDDACSSCAQLLVDGLVSFSLCVNISPR
QFRQNDFVERVLRSVDEHGLARQMLTLEITEGMVIQNLEDTIAKMRELKDHGVSFAMDDFGTGYSSLTYLKRLPVDALKIDQTFVRDALEDTNDAEIVRA
IVAMARSLKLAVIAEGVELQEQLSFLEQLGCHDYQGYLYSRPLPLDAFRQLLSAQK----
>tr|S6KGV6|S6KGV6_9PSED Sensory box protein OS=Pseudomonas sp. CF161 GN=CF161_16911 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALDSAQLGTWDWHIP
SGMLYGSARAAQLHGLDPAPFHESFDA-FFEGVPDEERDSMRNAYRSLREPAGNYQLTYRVQLEDGSSRYLESRRTLIRIKSSRQPCIVTTLRDITQQQR
SEAALKASEEAFHSSPDAIIIERESGRYLEVNDGFCRLTGYRTEEVLGHTLVAWAD-------------------VHHLEMLGRNKRGEIITLEVSVEPI
TLN--ETDCLLLTARDVSLLKNAQAQIRHLAYHDPLTNLPNRALLMDRLSQQIALLKRHNLRGALLFLDLDHFKHINDSLGHPVGDTVLKIITARLEASV
RMEDTVARLGGDEFVVLLSGLDGRQVRELADTLRELLSEPMFLDGQRLQVTPSIGIALIPDHGSTPTDLLKRADIALYRAKDSGRNTTQMFHNTMQKAAS
ERLRMETDLRLALSRGEFSVHFQPQVDARDNRIVGAEALVRWQHPELGAQSPTEFIKVLEDSGLILEVGTWILDEACLAFSQLINEGLIEFSLCVNISPR
QFRQNDFVERIEYCLAHYQLPSSLLKLEITEGIVIQNLEDTISKMRRLKKLGISFAMDDFGTGYSSLTYLKRLPVDTLKIDQSFVRDATHDPNDAEIIRA
IVAMARSLQLKVIAEGVETPQQLEFLQGLDCHLYQGYLHSRPLPLKDLRLMLR-------
>tr|W2DHQ3|W2DHQ3_9PSED Putative sensory box GGDEF/EAL domain-containing protein OS=Pseudomonas sp. FH1 GN=H096_24113 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALDSAQLGTWDWHIP
TGMLYGSARAAQLHGLPPEPFHESFDA-FFEGMPDDERESMRNAYRTLREPAGNYQLTYRVPMEDGSSRYLESRRTLIKIKSSRLPCIVTTLRDITQQQR
SEAALKASEEAFHSSPDAISIERDTGRYVEVNDGFCRLTGYRAEEAIGLTLIGWAD-------------------IHHLEMLWHNKRGELLAVEVSVEPI
TLN--ETPCLLLTARDVSLLKNAQAQIRHLAYHDPLTNLPNRALLMDRLSQQIALLKRHNLRGALLFLDLDHFKHINDSLGHPVGDTVLKIVTARLEASV
RMEDTVARLGGDEFVVLLSGLDGRQVQELADTLRELLSEPMFLDGHRLQVTPSIGVALIPDHGSTPADLLKRADIALYRAKDSGRNTTQMFHNSMQKTAS
ERLRMETDLRLALSRGEFSVHYQPQVDARGNRIVGAEALVRWQHPQLGAQSPSEFIKVLEDSGLILEVGTWILDEACAAFQQLIAEGLVNFSLCVNISPR
QFRQNDFVERVERSLKQHELPFSLLKLEITEGIVIQNLDDTISKMRRLKKLGVSFAMDDFGTGYSSLTYLKRLPVDALKIDQSFVRDATHDPNDAEIIRA
IVAMARSLNLEVIAEGVETQDQLAFLQGLGCHLYQGYLHSRPLPMIGFRERLLAGD----
>tr|K9NKL2|K9NKL2_9PSED PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. UW4 GN=PputUW4_03453 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALDSAQLGTWDWHIP
SGMLYGSARAAQLHGLEAKPFHESFDE-FFEGVPGEERDTMRDAYQSLREPAGNYQLTYRVQLPDGSSRYLESRRTLIRIKSSRQACIVTTLRDITQQQR
SEAALKASEEAFHSSPDAITIERDTGRYLEVNDGFCRLTGYRAEEVVGRTVVGWAE-------------------VHHQEMLGRNKRGELLTVEVSVEPI
TLN--ETACLLLTARDVSLLKNAEAQIRHLAYHDPLTNLPNRALLMDRLSQQIALLKRHNLRGALMFLDLDHFKHINDSLGHPVGDTVLKIITARLEASV
RMEDTVARLGGDEFVVLLSGLEGRQVRELADTIRELLSEPMFLDGQRLQVTPSIGIALIPDHGSTPTDLLKRADIALYRAKDSGRNTAQMYHNTMQKAAS
ERLRMETDLRLALSRGEFRVHYQPQVDARGDRIVGAEALVRWNHPELGAQSPTEFIKVLEDSGLILEVGTWILDEACQAFKKLIDRGLVKFSLCVNISPR
QFRQNDFVERVENSLATYGLPCTLLKLEITEGIVIQNLEDTIGKMRRLKKLGVSFAMDDFGTGYSSLTYLKRLPVDTLKIDKSFIRDATSDPNDAEIIRA
IVAMARSLDLKVIAEGVETAEQLEFLQGLECHFYQGYLHSPPLPVEEFQLLLK-------
>tr|G8Q576|G8Q576_PSEFL Sensory box/GGDEF family protein OS=Pseudomonas fluorescens F113 GN=PSF113_1902 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALDSAQLGTWDWHIP
SGMLYGSARAAQLHGLEPKPFHESFDA-FFEGVPTEERNNMRNAYRSLREPAGNYQLTYRVQLPDGSSRYLESRRTLLLIKSSRQPCIVTTLRDITQQQR
SEAALKASEEAFHSSPDAITIELESGRYLEVNDGFCRLTGYRADEVIGHTVVGWAE-------------------VVHQEMLGRNKRGEILTVEVSVEPI
TLN--ETACLLLTARDVSLLRNAEAQIRHLAYHDSLTNLPNRALLMDRLSQQIALLKRHNLRGALLFLDLDHFKHINDSLGHPVGDTVLKIITARLEASV
RLEDTVARLGGDEFVVLLSGLEGRQVQTLADTLRELLSEPMFLDGQRLQVTPSIGIALIPDHGSTPTDLLKRADIALYRAKDSGRNTSQMFHATMQKAAS
ERLRMETDLRLALARGEFSVHFQPQVDARDNRIIGAEALVRWHHPDLGAQSPNEFIKVLEDSGLILEVGTWILDEACDGFKQLIAKGKIQFSLCVNISPR
QFRQSDFVERIENSLIAHGLPFCLLKLEITEGIVIQNLDDTIAKMRRLKKLGVSFAMDDFGTGYSSLTYLKRLPVDTLKIDQSFVRDATSDPNDAEIIRA
IVAMARSLNLVMIAEGVETLEQLQFLQGLDCHLYQGYLHSRPLPLEAFERLLP-------
>tr|A0A0C2S9Z6|A0A0C2S9Z6_PSEST Strain YC-YH1 scaffold7, whole genome shotgun sequence OS=Pseudomonas stutzeri GN=QX25_03545 PE=4 SV=1
---------------------------------------------------------------------LESQERLE-------LALESVRLGTWDWHIP
SNMLYASARASDLQGVVSGPYHGPFGD-FFACVPEEDRHKMRRAYQDLVALRQEYQVIYRATGEDGQTRHLESTKIILRRRSSRFLSIITTFRDISKRQQ
AEAALRASEAAFRSSQDAITIERDSGRFIEVNDGFYRLTGYRPEEVIGRTALRWPG-------------------VTNMELLGLDRSGQSKSIAVSAEPI
ELN--GQQCLLLTARDVSQLKAAQAQVLHMAYHDPLTNLPNRTLLMDRLSQQGALLKRHDMRGALLFLDLDHFKHINDSLGHPVGDAVLKMITARLEASV
RQEDTVARLGGDEFVVLLTGLSGRQVRMVAEKLRQVLAEPMLFDGHHLRVTPSIGIALIPDHGDSPADLLKRADIALYRAKDAGRNAIQIFRKTMQDAAS
NRLRLEQELRQALLRGEFELHLQPQVDAQSGGIIGAEALLRWRHPQLGMQSPQSFIAVLEESGLIIEVGAWVIEEACRIVAALRDERLVAFSLCINISPR
QFRQTDFVERVVRALEHSDLPRQMITLEITESIVIQNLDDTIAKMRRLRQLGVGFAMDDFGTGYSSLTYLKRLPVDVLKIDQSFVRDALADGNDAEIIRA
IVSMADSLGLSVVAEGVELPAQLEMLQRQGCNRYQGYLFSPPVPVAQFQQLLLGDR----
>tr|I7ABW1|I7ABW1_PSEST Uncharacterized protein OS=Pseudomonas stutzeri DSM 10701 GN=PSJM300_06960 PE=4 SV=1
---------------------------------------------------------------------EDSQERLG-------LALNSVELGTWDWHIP
SDTLYASARAAELQGITEGSFHGPFQE-FFSCILPEDRSRMRQAYRELVEQRRDYQVTYQARLQDGTVRHLESTRIILRRRSSRFLCIITTFRDITLRQQ
AEAALRASEAAFHASPDAITIERSTGRFIEVNAGFYRLTGYHPEEVIGRTALAWPG-------------------VSNWEMLGQDRHGRPKHIEVSVEPI
ELN--GIQCMLLSARDISMLKAAHAQIQHLAYHDPLTNLPNRALLMERLVQQIALHKRQNLRGALLFLDLDHFKHINDSLGHPVGDSVLKMVTRRLEAST
RREDTVARLGGDEFVILLTGLSGRHVRDVAEKLRKLLAEPMTFEGNQLQVTPSIGIALIPDHGDTPADLLKRADIALYRAKDSGRNATQLFRSTMQEAAS
IRLQLESELRLALTRGEFELFLQPQIDSASGMIIGAEALLRWRHPERGLRSPADFIEVLEESGLIIDVGDWVIGQACRMAASLLAAGLVRFSLCINISPR
QFHQSEFVERILAALEQTGLPAQMIKLEITEGMVIQNLDDTIAKMHRLRRHGVSFAMDDFGTGYSSLTYLKRLPVDLLKIDQSFVRDALDNGNDAEIIRA
IVAMARSLGLQVIAEGVEQQGQLELLQLQGCQLYQGYLFSHPLPFTEFGELLRKQP----
>tr|U3B1C2|U3B1C2_PSEAC Uncharacterized protein OS=Pseudomonas alcaligenes NBRC 14159 GN=PA6_027_01000 PE=4 SV=1
---------------------------------------------------------------------RESQERLN-------LALESANLGTWDWHIP
SGTLYGSERAASLHGLPAEPFHGEFSQ-FFRRVPEQDQQQMRQAYREILDTQREYQVTYRIRLDNGENRCLESTKILIRSKSSRFLCITTTFRDITERQA
AEAALKASQEAFHSSPDAITIERDSGRFIEVNEGFCRLTGYRPEEVIGRTALQWAN-------------------VYHLEMHGQHRSGKLQLVEVSVEPI
ELN--GTPCLLLTARDISELKEAQAQVQHLAYHDPLTNLPNRALLMDRLIQQIALLKRHDLHGALLFLDLDHFKHINDSLGHPVGDAVLKMVTARLEASV
RQEDTVARLGGDEFVVLISGLEGRQVRQVAEKLRSLLAEPMLLDGHRLQVTPSIGIALLPDHGDNPTDLLKRADIALYRAKDSGRNTIQMFRKSMQEAAS
ERLRLENDLHLALARGEFELYFQPQVDARNGSVVGAEALLRWSHPTLGMQSPAHFIQVLEESGLILEVGGWVLSEACHAGARLMRDGLVTFQLCVNISPR
QFRQNDFVERVERCLQQNQLPASMLKLEITEGIVIHNLDDTIAKMRRLKKLGLSFAMDDFGTGYSSLTYLKRLPVDVLKIDQSFVRDATSDPNDAEIIRA
IVAMARSLNLEVIAEGVEQAEQLEFLLQQGCHHYQGYLFSKPVPLAEFHDLLQANR----
>tr|U3HS15|U3HS15_PSEST Histidine kinase OS=Pseudomonas stutzeri MF28 GN=L686_15785 PE=4 SV=1
---------------------------------------------------------------------EDSQERLE-------LALASAELGYWEWHIP
SDRLYASARASELHGIVEGPFDGSFRE-FFRSVAPNNRQTMREAYSDLLARHQTYQTTYQAQHPNGTARHLESTKIIIRSKSSRFLCIVTTFRDITKRQQ
AEAALKVSETAFHSSPDAIIIERRTGRFIEANEGFYRLTGYRSEEAIGRTSLKWPG-------------------VTNWEMVGQDRHGKPRHIEVSVEPI
ELN--GTDCLLLSARDISRLKAARAQIQHLAYHDPLTNLPNRTLLMERLNQQASLHKRHNMRGALLFLDLDHFKHINDSLGHPVGDAVLKMITARLEASI
RQEDTVARLGGDEFVVLLTGLTGRHVRQFAEKLRTLLAEPMVFEGNRLQVTPSIGIALMPDHGETPADLLKRADIALYRAKDAGRNAIQLFRTTMQEAAS
ARLKLESELRLALQRNEFELQLQPQVNARSGAVIGAEVLLRWHHPEHGTRSPAQFIDVLEESGLIVEVGDWVIKEACRIGAALLANRLVSFSLCVNISPR
QFRQSEFVERILATLKTTNLPHEMIKLEITEGIVIQNLDDTIAKMRRLCRHGVSFAMDDFGTGYSSLTYLKRLPVNLLKIDQSFVRDALEDSNDAEIIRA
IIAMARSLGLEVIAEGVEQQAQLDLLQLQGCHLYQGYLFSQPLRLTAFCQLLEAHS----
>tr|L8MD56|L8MD56_PSEPS Sensory box protein OS=Pseudomonas pseudoalcaligenes KF707 GN=ppKF707_1414 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALESADLGTWDWHIP
QGTLYGSARAAMLHGLPRAPFEGDIRR-FFDCVPAEDRRAMRRTYQNLLDHRDEYQSTYRTRLGSGKVRYLESTKILIRLRSSRFLCITTTFRDITDRQL
AEAALKASQEAFHSSPDAITIERETGRYIEVNEGFTRLTGYHPDEVLGRTAMQWAH-------------------VHHLEMLGQHRDGSRKMVEVSVEQI
ELD--GTPCLLLTARDISALKDAQAQIQHLAYHDPLTNLPNRALLTDRLTQQVALLQRHHMRGALLFLDLDHFKHINDSLGHPLGDAVLKMVTARLEASV
RLEDTVARLGGDEFVVLLTGLEGRQVRSIADELRQLLAQPMLLDGHRLQVTPSIGIALIPDHGTSPADLLKRADIALYRAKDSGRNAIQLFRSTMQEAAS
ERLRLENDLRQALVRGEFELHYQPQVDARDNRIIGAEALLRWQHPNLGPQSPGSFIRVLEESGLVLDVGAWVLDEACRTGQRLLADGLVHFDLSVNISPR
QFRQSDFVERVERSLASSGLPAHALTLEITEGIVIQNLDDTIGKMRRLKRLGVSFAMDDFGTGYSSLTYLKRLPVDALKIDQSFVRDSTLDPNDAEIIRA
IVAMARSLDLEMVAEGVERPEQLAFLEQQGCHLYQGYLFSKPVPLAEFRALLTLSR----
>tr|W8RC78|W8RC78_PSEST Histidine kinase OS=Pseudomonas stutzeri GN=CH92_13435 PE=4 SV=1
---------------------------------------------------------------------EDSQERLE-------LTLESAELGNWEWHIP
SDRLYASARASELHGIVDGPFDGSFRE-FFRTVAANNRQTMREAYGDLLLRRQSYQTTYQAEHADGTARHLESTKIILRSQSSRFLCIVTTFRDITKRQQ
AEAALKVSEAAFHSSPDAIIIERRSGRLIEVNEGFYRLSGYRPEEAIGRTSLGWPV-------------------VTNWEMVGQDRHGRPKHIEVSVEPI
ALN--DVDCLLLSARDISQLKAAHAQIHHLAYHDPLTNLPNRALLMDRLTQQTSLHKRHNLRGALLFLDLDHFKHINDSLGHPVGDGVLKMITARLEASI
RQEDTVARLGGDEFVVLLTGLSGRHVRQVAEKLRTLLAEPMVFEGNRLQVTPSIGIALMPDHGDTPADLLKRADIALYRAKDAGRNAIQLFRTTMQEAAM
ARMKMESELRLALQRHEFELQLQPQVDALSGAVIGAEVLLRWHQPEHGPRSPAQFIDVLEESGLIVEVGNWVLKEACRIGASLLASGLVNFSLCINISPR
QFRQSEFVERILDALKTTGLPPKMVTLEITEGIVIHNLDDTIAKMRRLCRRGVSFAMDDFGTGYSSLTYLKRLPVSLLKIDQSFVRDALDDPNDAEIIRA
IVAMARSLELEVIAEGVELQAQLDLLQLQDCHLYQGYLFSRPLPLAEFNELLISHS----
>tr|A0A078LRC2|A0A078LRC2_9PSED PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. 20_BN GN=BN1079_01148 PE=4 SV=1
---------------------------------------------------------------------QDAQDRLA-------LALSSLELGTWDWHIP
SDTLSTSIRAAELQGTFYRPFQGPFQE-FFSYVRPEDRAVMQQTYRDLLDRRQDYQAVYQTRLHDGNIRYLESTKIILRTRSSRFLCIITTFRDITARQM
AEAALRASEEAFHSSPDAITIELSSGRFIEVNEGFHRLTGYRPHEVIGRTSLAWPG-------------------VCNQEILAQDRHGQLKHTEVSVEII
KLN--GTDCILLTARDISQLKAAHAQIQHLAYHDPLTNLPNRTLLMNRLVQQIALHKRHNLRAALLFMDLDHFKHINDSLGHPVGDAVLRTVTTRLQTNI
RQEDTVARLGGDEFVILLTGLSGRHVRDVAEKLRKMLAEPMVCDGNRLQVTPSIGIALIPDHGETPADLLKRADIALYRAKDAGRNAIQLFQNTMQEAAS
ARLQLESELRLALLHDEFELFLQPQVDARSGAIIGAEALLRWQHPTHGLRTPAHFIDVLEDSGLIVEVGGWVIKQICQMAAELLASRLVTFSLSINISPH
QFRENDFVECILAALKEAELPQGMISLEITEGVVIENLDDTIVKMHRLRKHGVSFAMDDFGTGYSSLTYLKRLPVDLLKIDQSFVHDALNGGNDAEIIRA
IVSMAKSLGLEVIAEGVEQQGQLDLLQKQDCHLYQGYLFSKPLPFSQFIELLRE------
>tr|A0A0A1GC76|A0A0A1GC76_9PSED Sensory box protein OS=Pseudomonas sp. MT-1 GN=MT1_1927 PE=4 SV=1
---------------------------------------------------------------------EDSQERLE-------LALASAELGNWEWHIP
SDRLYASSRASELQGLVEGPFDGSFRE-FFRSVAANDRKTMRAAYSDLLARRQTYQATYQANHPDGTIRHLESTKIIMRMRSSRFLCIVTTFRDITKRQQ
AEAALKASEVAFHSSPDAIIIERGTGRFIEVNEGFQRLSGYSPEEAIGRTSLGWPS-------------------VTNWEMVGQDRHGRLKHIEVSVEPI
VLN--NTDCLLLSARDISQLKAAHAQIHHLAYHDPLTNLPNRTLLMDRLTQQTALHKRHKLRGALLFLDLDHFKHINDSLGHPVGDAVLKMITARLEASI
RQEDTVARLGGDEFVVLLTGLTGRHVRQVAEKLRTLLAEPMVFEGNRLQVTPSIGIALMPDHGETPADLLKRADIALYRAKDAGRNAIQLFRTTMQQAAS
ARLQLESELRLALQRNEFELYLQPQVDARSARVIGAEVLLRWHHPVDGVRSPAQFIDVLEESGLIVEVGNWVIREACRIAASLLTNGVVSFSLCVNISPR
QFRQSDFVERVLEALKAVSLPHTMIKLEITEGIVIQNLDDTIAKMRRLCRQGVSFAMDDFGTGYSSLTYLKRLPVDALKIDQSFVRDALDDPNDAEIIRA
IVAMARSLRLEVIAEGVEQQAQLDLLQAQGCYLYQGYLFSRPIPPADFEELLKTYS----
>tr|A0A0D0K2K2|A0A0D0K2K2_9PSED Strain MEJ086 contig_15, whole genome shotgun sequence OS=Pseudomonas fulva GN=RU08_06935 PE=4 SV=1
---------------------------------------------------------------------ADSQERLR-------MALESADLGTWDWHIP
SNTMFASARAATLHGLAAEPFHGPFLD-FFAHVPLMDRQAMRQAYRDLLPDGQDYQVTYRTVHPGKQTHYLESTKILLRLPSCRRPCVLSKFRDITEQQR
AEAALKASQEAFHSSPDAITITRDSGRYIEVNDGFTRLTGYSADEVIGQTSVNWAD-------------------IQRMEMRARDRDGNCVEVEVSVEQI
ELD--GQPCLLVTARDIGELKAAQAQIQHLAYHDSLTNLPNRALLMDRLTQQIALLQRHGLRGALLFLDLDHFKHINDSLGHPVGDAVLKLITARLEVSV
REEDTVARLGGDEFVVLLTGIEGLHARSTADKLRKLLTEPMLLDGHRLQVTPSIGIALIPDHGQTPADLLKRADIALYRAKDSGRNAIQLFHSTMQHAAS
ERLRLENELRMALARGEFELYFQPQVDARKDQIIGAEALLRWAHPTLGEQSPALFIHVLEESGLILEVGAWVMVEACHVCAQLLEERIINFSLCVNISTR
QFRQSDFVERVEHCLRKNRLPLGMLKLEITEGIVIQDIDETIAKMNRLRKLGVSFAMDDFGTGYSSLTYLKRLPVDVLKIDQSFVRDATSNPSDAEIIRA
VVALGLSLGLEVIAEGVEQQSQLDFLQSQGCHCYQGYLFSRPQPLNEFRALLAHSM----
>tr|F6A8H0|F6A8H0_PSEF1 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudomonas fulva (strain 12-X) GN=Psefu_3077 PE=4 SV=1
---------------------------------------------------------------------ADSQERLR-------LALESAELGTWDWHIP
SNTMFASPRAAMLHGLRDAPFHGPFPD-FFAHVPEQDLKGLRQAYRDLLPNGQDSQVTYRTVHGNGQTHYLESKRVMLRLPSCRRPCVLSKFRDITEQQR
AESALKASQEAFHSSPDAITITRDTGRYIEINDGFTRLTGYKAEEVIGRTSVSWSD-------------------VRRMEMKARDRHGNPLEVEVSFEPI
ELD--GTECLLVTARDISELKAAQEQIQHLAYHDPLTSLPNRALLMDRLTQQIALLQRHNLRGALLFLDLDHFKHINDSLGHPFGDAVLKLITARLEVSV
REEDTVARLGGDEFVVLLTGLEGRHAGQAAEKLRILLSEPMLLEGHRLQVTPSIGIALIPDHGQTPADLLKRADIALYRAKDSGRNVIQLFHGSMQHAAS
ERLRLENELRTALSRGEFELYFQAQVDARTDQIIGAEALLRWAHPTLGQQSPALFIHVLEESGLILEVGAWVMVEACHACARLLQDGLIRFSLCVNISTR
QFRQGDFVERVEHCLRQNKLPKGMLKLEITEGIVIQDIDDTIAKMNRLRKLGVSFAMDDFGTGYSSLTYLKRLPVDVLKIDQSFVRDATSNPSDAEIIRA
VVALGLSLGLEVIAEGVEQQSQLDFLQSQGCNCYQGYLFSRPQPLPAFRALLSQGA----
>tr|A0A0C2ILY8|A0A0C2ILY8_9PSED Sensory box/GGDEF family protein OS=Pseudomonas batumici GN=UCMB321_0334 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALDSAQLGTWDWHIP
SGMLYGSARAAQLHGLEPQPFHESFDA-FFDGVPASERESMRHAYRSLREPEGAYQLTYRVQLENGTSRYLESRRTLIRIKASRQPCIVTTLRDITQQQR
SEAALKASEEAFHSSPDAITIERDSGRYLEVNDGFCRLTGYTSGEVIGRTVIGWAD-------------------VPHRDMLGRNKRGDVLTVEVSVEPI
ILN--ETACLLLTARDISQLKNAQAQIRHLAYHDPLTNLPNRALLMDRLSQQIALLKRHNLRGALLFLDLDHFKHINDSLGHPVGDTVLKVVTARLEASV
RAEDTVARLGGDEFVVLLSGLSGRKVRELADTIRELLAEPMFLDGQRLQVTPSIGVALIPDHGTTPADLLKRADIALYRAKDSGRNITQLFHSTMQKAAS
ERLRMENDLRQALSRGEFSVHFQPQVDARDNSIIGAEALVRWHHPELGAQSPTEFIKVLEDSGLILEVGTWILDHACEAFGILLGDGLITFSLCVNISPR
QFRQADFVERVEHTLARYNVPSSMLKLEITEGIVIQNLEDTISKMRRLNKLGVSFAMDDFGTGYSSLTYLKRLPVDALKIDQSFVRDATHDPNDAEIIRA
IVAMARSLGLTVIAEGVELPEQLVFLEGLGCHLYQGYLHSRPLPLDEFKKLLI-------
>tr|V6JBC6|V6JBC6_PSEPU Diguanylate cyclase domain protein OS=Pseudomonas putida S610 GN=EDP1_3999 PE=4 SV=1
---------------------------------------------------------------------KDSQERLD-------LALDSAQLGTWDWHIP
SGMLYGSARAAQLHGLPPVAFHESFDA-FFEGVPEQERLSMRKAYSSLREPAGNYQFTYRVQLDNGVSRYIESRRTLIRIRSSRLPCSVTTLRDITQQQR
AEAALKSSEEAFHSSPDAITIECATGRYLEINDGFCRLTGYSAGDVVGRTVIGWTD-------------------VHHREMLGRNKRGELLTVEVSVEQI
MLN--DVECLLMTARDVSQLKHAQAQIRHLAYHDPLTNLPNRALLMERLGQQIALLKRRDLRGALLFLDLDHFKHINDSLGHPVGDAVLKIITARLEASV
RVEDTVARLGGDEFVVLLSGLEGRTVRQLADTVRALLAQPMSLDGQRLQVTPSIGVALIPDHGTTPADLLKRADIALYRAKDSGRNTTQLFHATMQKAAS
ERLRMESDLRLALGRGEMTLHYQPQVDARDNRIVGAEVLLRWHHPQLGQQSPGQFIQVLEESGLILEVGNWVLDEACVACARLLADGLIDFSLCVNISPR
QFRQNDFVGRVLRSLDDSQLPRKLLKLEITEGIVIQNLEDTIAKMRALQSHGVTFAMDDFGTGYSSLTYLKRLPVDALKIDQTFVRDVTIDPNDAEIVRA
IVAMALSLGLAVIAEGVELTEQLAFLEKLGCHLYQGYLHSRPLPLQAFRQLLQAP-----
>tr|F4DPG6|F4DPG6_PSEMN Sensory box protein OS=Pseudomonas mendocina (strain NK-01) GN=MDS_1993 PE=4 SV=1
---------------------------------------------------------------------NESKQRLR-------LALESADLGTWDWHIP
SSRLIASARASQLQGLDAATFEGAFLD-FFRKVPMEDRHNLRQSYQRLVQRRSHYQVTYRVHLENGGLRYLESTKTL-----------------------
------ASEEAFHSSPDAITIERDSARYIEVNEGFTRLTGYSPDEVVGRTAMDWAF-------------------VLHLEMHGKHRSGEVRLVDVSVQPI
ELD--GVPCLLLTARDISELKQAQAQVQHLAYHDALTNLPNRALLMDRLTQQISLLKRHDLRGALLFLDLDHFKHINDSLGHPVGDSVLRLVTARLEASV
RLEDTVARLGGDEFVVLLSGLEGRHVRQVADKLRQLLAEPMLLDGHRLQVTPSIGVALIPDHGNTPADLLKRADIALYRAKDSGRNAIQLFRTTMQDAAS
ARLRLENDLRLALARGEFELHFQPQVDARDGKVVGAEALLRWQHPQLGPQSPAHFIQVLEESGLIVEVGGWVLAEACHFCSQLLTGGLVRFSLCVNISPR
QFRQHDFVERVASCLRDSQLPNAMLKLEITEGIVIQNIDDTVGKMLRLKKHGVSFAMDDFGTGYSSLTYLKRLPVDMLKIDQSFVRDATNDPNDAEIIRA
IVAMARSLGLALIAEGVEQQDQLEFLQSQGCHLYQGYLFSKPLPQEAFHDLLSMQN----
>tr|U1ZAK4|U1ZAK4_9PSED Histidine kinase OS=Pseudomonas sp. EGD-AK9 GN=N878_08270 PE=4 SV=1
---------------------------------------------------------------------QESQERLK-------LALESADLGTWDWHIP
SNRLFGSARAAALHGLDACPFDDDFRE-FFRCVPLEDRQAMRLAYVALRERSANYQVTYRVRHPNGALHYLESTKTL-----------------------
------ASEEAFHSSPDAITIERDTARYIEVNEGFTRLTGYTPDEVVGRTALSWAY-------------------VLHMEMHGQHRDGGVRLVEVSVQPI
ELN--GVACLLLTARDISELKLAQAQVQHLAYHDALTNLPNRALLMDRLTQQIALLKRHELRGALLFIDLDHFKHINDSLGHPVGDAVLRLVTARLEASV
RLEDTVARLGGDEFVVLLSGLEGRQVRQVAEKLRRLLAEPMLLDGHQLQVTPSIGVALIPDHGDTPADLLKRADIALYRAKDSGRNAIQLFRSTMQEAAS
ARLRLENDLRLALARGEFELHFQPQVDARDGQVVGAEALLRWQHPQLGAQSPAQFIQVLEESGLILEVGGWVLAEACHLCARLLADGLIRFSLCVNISPR
QFRQHDFVERVAGCLRDSQLPNAMLKLEITEGIVIQNIDDTVGKMLRLKKHGVSFAMDDFGTGYSSLTYLKRLPVDMLKIDQSFVRDATHDPNDAEIIRA
IVAMARSLGLALIAEGVEQQEQLDFLQRQGCHLYQGYLFSKPLPQEAFRALLGRGP----
>tr|A0A0B2CZQ7|A0A0B2CZQ7_9GAMM Uncharacterized protein OS=Serpens flexibilis GN=SF06_33480 PE=4 SV=1
---------------------------------------------------------------------RAQELALRDSRERLALALESANLGTWEWHIP
T-----TPRAFAMHGLVVPEAGCDF-T-FFRTVHEDDRENLRRAYRGLL-TGSESELSYRARTPSGEIRHLESTRILVQNKSCRYCYVAISFHDITRLQQ
ATRALQASEEAFHSSPDAICLERDGQRFLEVNEGFRRLTGYTPEEVTGRSVLRLRIDPQQRQEILD-----------RTEVHLLDRDGREKFAEVSVETL
RLDGGE--CLLVTARDISQLKAAQAQIQHLAYHDPLTNLPNRALLLDRLTQQIALLNRHNLRGAVLFIDLDHFKHINDSLGHPVGDAVLKMLTARLEANV
RLEDTVARLGGDEFVVLLSGLEGRQVRQVAEQLRAHLAEPMDVEGHPLQVTSSIGVALIPDHGTSPDDLLKRADIALYRAKDSGRNRLHLFRSRMQEQVS
ERLRIENDLRQALQRQQFEVRFQPQVDTRSGCIVGAEALLRWNHPVYGMQSPESFIQVLEESGLIHDVGLWVLNEACQTCARLLDETLIRFSLCVNISPR
QFRHPEFYEGIERCLSRSRLPAHMLKLEITENVAIRNVEDTVNKMQRLKRLGIGFAMDDFGTGYSSLTQLKRLPVDVLKIDQSFVRDVPLNGNDSEIIRA
IIAMANSLGLQTIAEGVERSEQLDFLRGENCQLYQGYLFSQPLPLAEFREVLARPP----
>tr|A0A0A1YNK3|A0A0A1YNK3_9PSED Sensory box protein OS=Pseudomonas taeanensis MS-3 GN=TMS3_0112275 PE=4 SV=1
---------------------------------------------------------------------KESQERLT-------LALDSANLGTWDWHIP
SDTLYGSERAATLHGLPAEPYHGDFGK-FFHYVPEEDQRLMRRAYRELLERQQVYQVTYRSRFANGEIHYLESTKVLIRTRSSRFLCITSTFRDITEHQR
AETALKASQEAFHSSPDAITIERDSARYIEVNEGFCRLTGYRQEEVIGRTAMNWAN-------------------VLHREMLGRHRDGRLKTVEVSVEPI
DLD--GIDCLLLTARDISQLKEAQAQIQHLAYHDSLTNLPNRALLMDRLTQQIALLKRHELRGALLFLDLDHFKHINDSLGHPVGDTVLKLVTARLEASV
RQEDTVARLGGDEFVVLLSGLEGRQARKVAEKLRHLLAEPMLLDGHRLQVTPSIGIALIPDHGSTPADLLKRADIALYRAKDSGRNTIQLFRSTMQEAAS
ERLRLENDLRLALARGEFELYFQPQVDARTGKIIGAEALLRWQHPLLGAQSPALFIHVLEESGLILEVGGWVLAEACHVCAQLLDENLIDFSLCVNISPR
QFRQNDLAERVESSLRNSKMPKSMLKLEITEGIVIQNIEDTIAKMNRLKRIGVSFAMDDFGTGYSSLTYLKRLPVDVLKIDQSFVRDATCDPNDAEIIRA
IIAMARSLDLEMIAEGVEQQDQLDFLELQGCHQYQGYLFSKPLPLPEFRALLAHTR----
>tr|S6AU04|S6AU04_PSERE Putative sensory box protein OS=Pseudomonas resinovorans NBRC 106553 GN=PCA10_20040 PE=4 SV=1
---------------------------------------------------------------------KDSQERLN-------LALESADLGTWDWHID
AGTLYGSARASALHGLAREPFEGEFRD-FFVYVPDEDRQNMRRAYQEVLEESDEYQVTYRARFDNGEVHYLESTRILIRLFSSRFLCITTTFRDITARQQ
AEAALKASQEAFHSSPDAITIERDTGRYIEVNEGFCRLTGYRADEVLGRTAMNWAN-------------------VHHLEMLGQHRDGSHKVVEVSVEQI
ELD--GKTCLLLTARDISALKDAQAQIQHLAYHDPLTNLPNRALLTDRLKQQIALLRRHGMRGALLFLDLDHFKHINDSLGHPLGDAVLKMVTARLEASV
RMEDTVARLGGDEFVVLLTGLEGRQVREIADKLRKLLAEPMLLEGHRLQVTPSIGIALIPDHGDSPADLLKRADIALYRAKDSGRNAIQIFRKTMQEAAS
ERLRLENDLRLALARGEFELHFQPQVDARNNRVTGAEALLRWHHPTLGPQSPGQFIQVLEESGLILEVGAWVLDEACNACEQLVAEGLVDFSLCVNISPR
QFRQSDFVERVERSLQRSQLPAQLLKLEITEGIVIQNIEDTIGKMRRLKKLGASFAMDDFGTGYSSLTYLKRLPVDALKIDQSFVREATQDSNDAEIVRA
IVAMAHSLGLEVIAEGVEQAEQLAFLEQQGCHLYQGYLYSRPVSLAEFRALLARTS----
>tr|U3HET1|U3HET1_PSEAC Uncharacterized protein OS=Pseudomonas alcaligenes OT 69 GN=L682_10420 PE=4 SV=1
---------------------------------------------------------------------KDSQERLA-------LALESADLGTWDWHIP
SSSLYGSARASALHGLATEPYEGDFKN-FFSFVPLEDQMAMRQAYQDLLTVTKDYQFTYRSRFANGEIHFLESTKILIRMQSSRFLCITTTFRDITERQQ
SEAALKASQEAFHSSPDAITIERDTGRYIEVNEGFCRLTGYSAEEVIGRTALHWAR-------------------AHHLEMSGQHRDGTRKVVEVSVEQI
DLD--GKACLLLTARDISALKDAQAQIQHLAYHDSLTNLPNRALLMDRLTQQIALLRRHKLRGALLFLDLDHFKHINDSLGHPVGDSVLKMVTARLEASV
RLEDTVARLGGDEFVVLLTGLEGRQVRQIADKLRKLLAEPMLLDGHHLQVTPSMGVALIPDHGETPADLLKRADIALYRAKDSGRNAIQMFRATMQEAAS
ERLRLENDLRLALVRGEFELYFQPQVDARSNRVIGAEALLRWMHPTLGPQSPAQFIQVLEESGMILEVGSWVLAEACRACERLLVDRLADFSLCVNISPR
QFRQNDFVERIEKSLVDTRLPHGILKLEITEGIVIQNLDDTIGKMRRLKKLGVSFAMDDFGTGYSSLTYLKRLPVDVLKIDQSFVRDATNDPNDAEIIRA
IVAMARSLGLGMVAEGVEQKEQLDFLEQQGCHLYQGYLFSRPVPLEEFRALLARNN----
>tr|A0A0D6SHB9|A0A0D6SHB9_9PSED Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudomonas sp. FeS53a GN=SZ55_3405 PE=4 
---------------------------------------------------------------------RDSQERLA-------LALESADLGTWDWHIP
SGRLYGSARASALHGLAPEPFDGDFHL-FFASVPAEDRRTMRKAYQELQDQQTRYQLIYRSRFANGEVHYLESTKTLIRMHSSRFLCITTTFRDVTERKQ
AEAALKASQEAFHSSPDAITIELESGRYIEVNEGFCRLTGYSAEEVIGRTAMQWSD-------------------ALHLEMVGRHRDGHTKTVEVSVERI
ELD--GKACLLLTARDISALKDAQEQIHHLAYHDPLTNLPNRALLMDRLTQQIALLKRHDLRGALLFLDLDHFKHINDSLGHPVGDAVLKMVTARLEASV
RLEDTVARLGGDEFVVLLSGLEGRQVRQIADKLRKLLAEPMLLDGHHLQVTPSIGIALIPDHGQTPADLLKRADIALYRAKDSGRNAIQLFRSTMQEAAS
ERLRLENDLRLALARSEFELHYQPQVDARSNRIVGAEALLRWVHPTLGPQSPGQFIQVLEESGQILEVGSWVLEEACRNCATLIADGLIDFSLCVNISPR
QFRQNDFVERIEKSLSNSHLPRRLLKLEVTEGIVIQNIDDTIGKMRRLKKLGVSFAMDDFGTGYSSLTYLKRLPVDVLKIDQSFVRDATNDPNDAEIIRA
IVAMARSLGLGMVAEGVEQPEQLEFLEQQGCHLYQGYLFSRPLPFSAFRTLLKPAT----
>tr|M5QVC7|M5QVC7_9PSED Sensory box protein OS=Pseudomonas sp. Lz4W GN=B195_18491 PE=4 SV=1
---------------------------------------------------------------------IDSQERLD-------LALDSAQLGTWDWHIP
SDRLYGSARAAQLHGLPAEPFNESFEA-FFDGVPEAERDNMRDTYRTLREPAGSYQLTYRVPGENDTSRYIESRRTL-----------------------
------ASEDAFHSSPDAITIELATGNYLEVNDGFSRLTGYSSAEVIGRSPLGWGH-------------------IRNREILGRSRRGALLNLEISIEPI
TLN--DTPCLLLTARDISQLKAAQAQASHLAYHDPLTNLANRSLLLERLNHQTELLEHHDLRGALLFLDLDHFKHINDSLGHPVGDSVLKIITARLEASV
RSEDTVARLGGDEFVVLLTGLKGLNVLRTADTLRELLAEPMFLDGQRLQVTPSIGIALLPDHGITATDLLKRADIALYRAKDCGRNTSQLFDFSMQAAAS
ERMNMESALRTALARNEFSLHFQPQVDARENRIVGAEALLRWQHPQLGAQSPADFIKILEDSGLILEVGAWILDEACRSFGKLLREGLIAFSLCVNISPR
QFRQSDFVEQVKRSLLHHDLPCSMLKLEVTEGIVIQNLEDTIAKMQALIALGVSFAMDDFGTGYSSLTHLKRLPVDTLKIDQSFVRDAINAPNDAEIIRA
IVAMARSLKIKVVAEGVEQAAQLQFLQSIGCHLYQGYLHSRPVPLAQFRKLLQH------
>tr|I3YFQ7|I3YFQ7_THIV6 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiocystis violascens (strain ATCC 17096 / DSM 198 / 
---------------------------------------------------------------------REAIDALR---K---ERDTVRNILQTVEAII
VRMTLINRKGCQLLGYDEAELIGKDWF-MTCLPRNSDVES-IRSLFRKTIDGDLAGVENAVRTRSGEERLIAWHSAGHNDHSGEFLGYIGYCLDITGEVQ
KASALRASEAILRAAPVGIGVV-VDRRFQEVNDTMLRMTGYRREDLIGQSSRLYPS-----DAEIQIR----HNG----DFRIVQKQGEILWVTHKCRPI
FRADGHYQGRRVTVRDISARKEADEQIRRLAYFDPLTGLPNRRLLMDRLAYALVASQRSQEFGALIMLDLDHFKTLNDTQGHDEGDRLLIEVARRMIGCL
REEDTVCRLGGDEFIVMLQGLGKEDAETIAEKMRLVLNEPYVLTASPYFSTPSLGLTLFLGQETSVEVLLKQADVALYQAKDAGRNRVRFFSPAMQTAID
SRMAMEAALRQALLQGEFQLFYQPQFDQ-NGRRIGAEGLLRWRQPGRGLILPMEFIPLAEETGLILPIGQWVIDTACDQLKAWEDQAHTFLQLAVNVSAR
QFHQPDFAARIRASLKRSGANPERLKLELTESVVLENAEAAINQMHQIKALGVSFSLDDFGTGYSSLSYLKRLPLSQLKIDRTFLRDIGTDPNDAAIVRA
ILAMSRSLGLEVIAEGVETEAQRRFLHESGCHAYQGYFFGKPNPIEDWDTASRS------
>tr|G2E200|G2E200_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_2313 PE=4 SV=1
---------------------------------------------------------------------TH--ERLR---L---KQETL-----------
-----------------------------------------------------------------------------DYDHHGTFIGYIGHCLDITAARR
SQEALAQKERLLDNFPFAVWLKDTERRFLAVNQALADSVGAASDALIGRTEAVWPTGISDQPISISDRQCLESDG----ELRIRRRNGDFFWATHRCRQV
RDAAGNDHGRRVTVRDISARKEAEEQIRNLAYFDSLTGLPNRRLLLERLGHALIASRCNQHYGALLMIDLDHFKTLNDTQGHEKGDRLLIEVAHRMSQII
RAQDTASRLGGDEYVLLLETLGQERAEGIAEKIHHRLSAPYVISGDTHYCTCSIGLTLFNGEEQTVEVLLKQADVALYQAKDAGRNTTRFFNPAMQMAIE
SRMALETALRQALARDELQLHYQPQIDQ-NGRCIGAEALLRWQRPDLGLISPMQFIPLAEETGLIFPIGRWVIDTACAQLKTWEAQPATSLQLAINVSAR
QFHQPDFVAQVSDSLERSGANPARLKLELTESVILENADPVIERMRQLHALGVGFSMDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDITTDPNDAAIVRA
ILAMSHSLGLQVIAEGVETEEQQIFLRENGCDAFQGYLFGRPIPIGEWPLDPNQSD----
>tr|G2E2J1|G2E2J1_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_2423 PE=4 SV=1
---------------------------------------------------------------------GDAMERLR---Q---EHDTIRNILQTVEAII
VRITLVNRKGCQLLGYQEAELIGRDWF-STCLPHDIDVAE-IRAIHRNILNGDLLGVDNPVRTRSGAERLIAWHNAGY-VRSAHLTCILSITRDITDKKR
AEEALRDSEAILRVAPVGIGVV-VRRLFMEVNDTLLRMTGYRQDELIGQSARLYPS-----DAEDQIR----CDG-------------------------
-------------------RKVHEEQIRNLAYFDPLTGLPNRRLLVDRLEHALIASHRSRQYGALMMLDLDQFKAINDTLGHDVGDRLLVEAAQRMTTSV
REGDTVGRLGGDEYVVILENLGTEATEMTAEKVRFALNMPYALASAAHYCTSSIGLTLFRGHDTSIEVLLKQADVALYQAKGAGRNTARFFNPNMQKTIE
SRMALETALRQALFKGELQLFYQPQIDQ-NGRCFGAEALLRWRRPGHGLVAPLEFIPLAEETGLILPIGQWVMDTACAQIKAWEASERTFLRMAVNVSAR
QFHQPDFVAQVQASLERYGANPHRLKLELTESVVLENAEQVVSRMNQLRALGVSFSMDDFGTGYSSLSYLKRLPLDQLKIDKSFIRDIATDPNDAAIVRA
ILAMSQSLGLEVVAEGIENEAQRRFLCENGCHRFQGYLLGKPKPIEEWETRPDLGA----
>tr|Q3A1G1|Q3A1G1_PELCD Sensor diguanylate cyclase/phosphodiesterase, 5TM, PAS, PAS and PAS domain-containing OS=Pelobacter carbinolicus (strain DSM 23
---------------------------------------------------------------------DQISKALQTSEERLRMALKASKQGLYDLN--
-GNMIVNAEYALILGYDPQNFRETNGD-WIARMHPEDRSAVLAVYRNY-LAGKTEEAEFRRT-RCGQWKWVLSMKTFTRAKTAMRVGYLGIAQDITERKR
QENTLRKLSQVVEQSPTAVILTDPQGNIEYANPKFTQITGYSLTEVHGKNPRLLKSGET--SAERDLW-----------EFHNKRKDGSLFWEHASISPV
RNDAGDISHFLAIKEDITDRKRYEEQLQHLATHDNLTGLANRALLQDRLEQSILFAKRSGRLVAALLLDLDRFKIINDSLGHSFGDRLLQIAADRLRESV
RGADTVARLGGDEFVILLAEVANEDVGKVAKKILDRITAPFQIADREITVTASLGISIYPQDGEDEETLIRNADIAMYQAKEEGN-AFRLYAPEMNIVVH
EAMEMETDLRRALDRGELLLHYQPKIDLDSGKITGAEALVRWQHPVRGMIAPGMFIPLAEETGLILPIGEWVLENICLQIKSWQTQGFPLVPIAANLSAR
QFRNDELIATIQRILQDTGLPPHLLELELTESMIMRNVQTAAETMQELNALGVSLALDDFGTGYSSLNYLRRFPVDCLKIDRSFISDVADDPSAAAVATS
IIAIAHSLGLQAVAEGVETEEQLEFLRQCACDSYQGYLYSAPLAVEEFTAMLRQES----
>tr|E1QF27|E1QF27_DESB2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-180
---------------------------------------------------------------------RQSEQRFRGSENDII------LSPDGRFTYV
-------RAWRRILGHAAEEVLGRY---FIEFAPPDSVDDYRRLFKAVRDGKKTLYGAHPMLHKNGEVRHLAMSAMLLLLHRGEPISMIGAVQDITGIRA
SEEQMRLLA-VFENTVEGIIVTDADGVIEMVNAAFCAITGFDAAEAVGARPSILSSGRHDAEFYQRMW-----------EVWNRRKNGEAYPEWLTITAI
KDKSDRTTHLVGVFHDITEAKRNEERITHQAYHDALTGLPNRQLFNDRLAMAIAQAHRGGHGLALLFLDLDNFKNINDSLGHAVGDMLLQAVAQRLTRWL
REEDTVARLGGDEFVMLIQGASDDYIMQVARRILDSMSQPFAVGPHELYVTASIGVTIHPHDGHDAQTLVANADLAMFRAKDEGRNNIKLFTPAMNAKVM
RRMELEANLRKALEREEFEVFYQPKVELRSDKVVGVEALVRWRRPDSVVVSPDEFIPICEETGLILPLGKWVLEQACSRAKYWHDMGFDGLNVSVNLSPR
QFQDNHLVDHVGEILAQTGLAPHCLELEITEGVVMHSVDEAIETMNRLSSMGVRLSLDDFGRGYSSLYYLKRFPMSSLKIDRSFVADIATDPDDASIVNT
IISMSRSLNLQVVAEGVETKEQLDFLRSKRCDQMQGYYFSRPLPARELTELLEGLR----
>tr|A0A0D2GB60|A0A0D2GB60_9DELT Contig_4, whole genome shotgun sequence OS=Desulfarculus sp. SPR GN=X474_19920 PE=4 SV=1
---------------------------------------------------------------------EDSEERFRCSENDII------LYNDGSFSYV
-------PAWKRILGHEPEEVAGRF---FSDFSPPGQDRRFKKIFERIGREAETVHVNCTLRHKDGHDRILDLSAMLFTGPSNEPLALAGAVQDITELKK
SEQRIRLLA-VVENTIEGIMVTDEKASIVLVNQAFTAITGYEPNEVVGAKPSILSSGRHPADYFQRMW-----------EIWNKRKDSHLYPAWLTVTAI
KDHKDRVSHYVGVFHDITEVKRNERKIAYQAYHDALTGLPNRLLFYDRLQMAIAHANRKGLFLAVMFLDLDNFKDINDSLGHHVGDLLLKKVAERINRWV
RGEDTVARLGGDEFIMLLLGNEKVQAKKVAQRVLHSLAEPFEIEENKLFINGSIGITIYPTDGKDPQTLLSNADLAMYQAKDQGRNTYRLFTREMNQKVM
QRVSMEASLRQALEKGEFRVYYQPQVDLNTGSMVGAEALLRWEHPGKGLLGPDEFIPLAESSGLIVPIGEWVLAQACSQARSWHDQGFRGLLVSVNLSPR
QFQQPNLVSQIRSILTQTGLDPSCLELEVTESVVMQNVEDAILTMSRLCKLGVRLSLDDFGRGYSSLYYLKRFPMHTLKIDRSFVRDITLDQAGAAIVNT
IIDMSGNLSLKVVAEGVETKEQLQFLKINRCDQMQGFLFCRPIPQKDLTTLMTEGK----
>tr|A0A0D2HNQ3|A0A0D2HNQ3_9DELT Contig_4, whole genome shotgun sequence OS=Desulfarculus sp. SPR GN=X474_20815 PE=4 SV=1
---------------------------------------------------------------------EEVQGKYQEFENELF------HDFEGKFTEL
-------RAFRRFIGTISAKTEEIK---VVDLLQPGQRSSFDNYIKQIISTGE-ACGTIEFVTRKGQKRLVEYTTAAMNCPHGRAAVLSGVLQDITQRRL
SEQRVRLLA-AFENALDGMIITNENGVIQMVNPGFTAITGYSAQEAIGRNPSILRSNRTSAKLHKAMW-----------EIFNRRKNGQTYPQWLSIRAI
KNEIGKVSHYVGALHDLTELKQGEAKIAHQALHDALTGLPNRIFFNERLADAMREVSKHNGKLALLFLDLDNFKNINDSLGHAVGDKLLSATAERLLSLV
RDQDTVARLGGDEFIMILKDPGSDQATGAANRIIKAMSQPFWINEREMYITASIGITIYPDDGEDLEALVSNADMAMYQAKDVGKNTTRIFTRDLNTRIK
RRMSLEESLRNAIKNEELEVYFQPKVDLRTGSMAGAEALVRWNHPDKGLIGPDEFIPLAEETGLIIPLGRWVLRNSCRTAKAWMNHGHQCMQISVNLSPK
QFTQKDLPQMVGNTLSDTGLPPYALELELTENMVMQNVDEAINTMHRLSNLGIQLSLDDFGRGYSSLYYLKRFPMNELKIDRSFVDDIPSDPDNASIVNT
IISMGRSLNLRVVAEGVETKEQLSFLKKNNCDQMQGYFFQAPIPALDLLRLLQRGK----
>tr|G3IR02|G3IR02_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_2433 PE=4 SV=1
---------------------------------------------------------------------KASETALQ---E---ALDRLQKIASRVPGLV
FFPFA-SEAIRDIYRVSPEDVRDDASR-VYAVLHPDDYDGIVASIQASARRLTPWRHEYRVKFDDGTVRWLFGNLFIHNDFQDTFLGYIGSCIDITRRKL
SETDLRIAS-TAFESQEAMAITDKDQVILRVNQAFVRVTGYSVEEAVGKTPALLKSGRQDAPFYQAMW----SDG----EIWNRRKNGEVYPEWLNITAV
TDEGGQVTNYVASFSDITERKTAEYEIQHLAFHDSLTQLPNRRLLLERLKHGIEVERREGKQLALLMLDLDRFKAVNDSFGHQAGDELLQQVARRITSRL
REVDMVARLGGDEFIVLLEDITHD--ARVAEGIIADLSKSFQLPQSDVQIGVSIGISLYPQHAVNPEMLLDYADTALYHAKDNGRGCFAYFSEDLTIAVR
ERIALEVRLRKAIKQQELRVFYQPQMDIASGRIVGAEALVRWQDPVEGLIPPCRFIPIAEETNLIVEIGEWVLRETCRQGRQWLNMG-LPLTLAVNVSPH
QFRRSDINALVATVLRDTGFPAGQLELEITESGLMENQDKTTNILNSLHAQGVHLAIDDFGTGYSSLTYLKHFPLDVLKIDKSFIDDIPHNKDDMEIAAT
IVAMGHILGFKVLAEGVETLEQLAFLQEQSCDLYQGYLKSHPLPADDFVALLQAND----
>tr|A0A0D2HYZ7|A0A0D2HYZ7_9DELT Contig_11, whole genome shotgun sequence OS=Desulfarculus sp. SPR GN=X474_04325 PE=4 SV=1
---------------------------------------------------------------------RVSEQRFRNSESDII------LDLSGAFTYV
-------PAWKRLLGHEPGEVYGKF---FVEFAPPGEEDSYIHIFQIRNRRKTMSDMDSRLMAKDGTVRHFSLSSIFEKQKRGVQKGLYGIYRDITHRKR
AEQALRESEEALEAAPDPVVVYDMQGRVVYLNPAFVSVFGWCLSETIGKKMDFVPPEKASETD--VLV-----------ETVRMTKAGRSVEVRISGAPF
FDSKNEPMGCVVTLQDITRRKEAEAQLKYLAFHDTLTGLPNRKAFYHTAQEKQGPHRRESDTWALLFLDLDRFKDINDSLGHDVGDLLLRRVATRIQESI
RQTDQLFRLGGDEFTVIINKLVNIDAARVAQKICDNLAAPFEIKGYRLFLSASVGISVYPHDGHSLDDMMKNADMAMYAAKAEGN-GPRFFTAEMNTNAQ
HRLYLEHSLRGALDRQELSLHYQPLVDDN-FQVQGVEALLRWEHPSMGFIPPTNFIPIAEETGVIIPIGEWVLKQACREVKELSDTIGRSLYVAVNLSPR
QFGQNGLVSTVKEALSSSGLSPDRLKLEVTESSVMVDPEEAIAKMELLNQLGVTFSIDDFGTGYSSLSYLKRFPVEVLKIDRSFISESQENSNDREIIKT
IIAMAKNLRMKTVAEGVETRAQRDFLCRQGCFLMQGFYFSQPMPFKKLLADWDFLT----
>tr|K9DFM0|K9DFM0_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia timonae CCUG 45783 GN=HMPREF9710_02621 PE=4 SV=1
---------------------------------------------------------------------RPALAPRSTLGDRFDFLQRVAQVGLWEMRVR
--RLYVSDEMRTLFGICADAPDPDFAT-LFTRVHPDDQHSVEAQIAHALQYGTPLDMEHRVVWPDGAVRHVHARDSVTKRL----TGLAVYMRDITLQKL
TEDALRQSEE-ARVTSDAIWDLDVRTDTLWFGASLHELFGYAPDEFQASLSLWDRIHPDDRQR-VI-------------DYRFIRKDGSVAHVHDRAQIL
RDGDGTALRVVGAVIDVSERHAADLHIRYLAFHDTLTRLPNRAFLTERLEAALAAARGDARRKALLLIDLDNFKTLNETLGHAVGDRLLQQMAIRLVAGL
PSDVVAARFGGDEFGVLLENLPAKQAKHEGERINYLLNQPVQLDGYWLQLGASIGITVFSDDAVDAGDLLRRADLAMYRAKAAGRGTVRFFDPSLQAAAA
ARLTLENDLRAGLRDHAFFLHYQPQVER-DGRIVGVEALVRWRHPKRGTVSPVEFIPLAEETGLALPLGHWVLERACRQLSDWAGQAETHLEISVNVSAR
QLHHPAFVAQVLGCLGPSGADPRKLKLEITEGSLLDDIEDAIGKINALKAHGLTFAIDDFGTGYSSLAYLKRLPLDMLKIDRSFVLDLTTNPNDAVIART
IIALGASLGLKVLAEGVETEDQRDFLFANGCQAYQGYLCARPLEAQALAGMLRKR-----
>tr|Q12GF0|Q12GF0_POLSJ Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Polaromonas sp. (strain JS666 / ATCC BAA-
---------------------------------------------------------------------QQSRMRLQHSENRLHIAMRTAQMGNWSLNLA
--SLTLSSEFPAILGTSAAM-PQTLEE-LLLHYAAESRGRLRHVISECARKGTPFDEEAQMLTAQDGRRWVRIIEALTQAL----EGLAVYFRDVSERRN
SQEQLMLLETIVVIVEASPH-HGSGPQIVFVNDAFERHTGYTRDEVLSRMPGM--QGPGTRQD-EL-------------ELVIYRKDGGSFWVDLEIVSV
AAQNGDLTHWVAVGRDITQRKAADEKIHHLAFYDPLTELPNRQLLLDRLEQALADCTITRQEGVLMFIDLDNFKILNDTVGHSKGDLLLQKVAVRLKGCV
RKLDTVARLGGDEFVVMLQDLGTPKAQIVAEKVLATLREPYDLAGYQHYSTSSIGVTPFNARQGSVSELLKQADLAMYQAKTMGRNTVCFFDPDMQASVS
ANAALSTDLRAGLREHQFLVHYQPQVDR-EQRITGVEALLRWKHPQRGMVSPAEFIPVAEETGLILPLGQWVLEQACLQLAVWQKRPETGLSIAVNVSVR
QFRHPDFVDMVMAAIKHTGIQPHNLKLELTESLLADRMEIAIAKMGTLKALGVTLALDDFGMGYSSLSYLKRLPLDQLKIDKSFIADVFSDPNDAAICSA
IISLAQSLGLDVIAEGVETEAQRSFLAGLGCGYYQGFLFCPPLPIAEFEAFMQGAA----
>tr|A1VIX7|A1VIX7_POLNA Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Polaromonas naphthalenivorans (strain CJ2) GN=Pnap_0281
---------------------------------------------------------------------GQVPTALQQAGHRLAMTERIAHIGSWALDLP
-QLLTYSSEFAAILGLPADA-PLTWDE-LADRFAPEYRKRIAALLQQCASHGTAFDEEMQID-TPLCRKWVRMAEVLTKAL----EGLAVYFRDVSKRRK
SQEQLMLLETIVLIAEAQSG-SPKVPYIVFVNQAFEEHTGYSGHEVLGQTPRK--FGPGAVQD-EL-------------ELLIYRKNGSCFWLELEIVQV
AVTADELTHWVAVGRDITQRKVNADAIHQLAFYDPLTTLPNRLMLLNRLEQVMAQSAHPRRQGALMFIDVDKLKVLNDTLGHHKGDLLLQQVAERLAGCV
EDTDMVARLGGDEFVVLLENLGDAHARQLAEKVLEQLREPFDLGGHQHYTTSSIGVTSLNAAHGSVSEVLKQADLAMYQAKTTGRNALCFFDPEMQAAVN
ANAAVSSELHIALRKQEFVLHYQPQVDS-QGRVNGVEALLRWHHPKRGLVMPTDFIPMAEETGLILPLGRWALATACEQLAAWAAWPQADLSIAVNVSVR
QFRHPDFVDQVMAEIRRTGIKPQHLKLELTETLLADGMDVTLARMGTLKALGVTLALDDFGMGYSSLSLLKRLPLDQLKIDKSFVAEVLTDPADAAISRT
IITLAHSLNLKVVAEGVETQAQQDFLVAEGCDQFQGFLFSAPLPIEALEAYLMAQS----
>tr|I4MI96|I4MI96_9BURK Diguanylate cyclase/phosphodiesterase OS=Hydrogenophaga sp. PBC GN=Q5W_4147 PE=4 SV=1
---------------------------------------------------------------------AQVALH-RRHQGQIELVERTAGLGSWSVETD
--RVDCSAGLLSLLGIDTEAPPRTLED-LLAHHAPEWRQGLRQRLERCAASAEPFDEEVQVLIESNGAKWVRTVATVTVQL----EGLAVYFRDVTERRR
SQEQLMLLETIVLIAETGAQERRGEPKIVFVNDAFELHTGYSRAEVLGQSPGM--LDLDPAVS-KL-------------ELMVRRKNGALFWVELEVVSV
QPSADEVTHWVAVGRDITQRKTAEDMIRHLAFYDPLTDLPNRQLLLDKLQQALSVSARSGQHGALLFIDLDNFKILNDTLGHQMGDQLLKKVAQRLTASV
RKTDLVARLGGDEFVVMADDLSPPKARVLANKVLQTLREPFALTGHQHFATPSIGVTIFHGTQADVGELLKQADLAMYQAKSMGRNTLCFFDPSLQAEMS
ENARTASDLRDGLRRREFVVHYQPQVDK-AGMIIGVEALLRWNHPERGLLSPIAFIPVAEDTGLILPLGLWALETACGQLAAWSKRPETNLSIAVNVSVR
QFRHPDFVDSVMACIRASGVKPQRLKLELTESLLADRMEITIEKMGMLKSLGVTLSLDDFGMGYSSLSLLKRLPLDQLKIDRAFVADVLTDPNDAAISRA
IIALAQSLSLQVVAEGVETIEQRDFLAYQGCDQFQGHLFAKPLPIEALDALLSNPV----
>tr|A0A068YUW8|A0A068YUW8_9BURK Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Polaromonas sp. CG9_12 PE=4 SV=1
------------------------------------------------------------------------------------MAERIAHAGSWKMDLK
-QRVSCSTEFSALIGLLPEL-AITRDE-LIARFSSEYRDRIGWLFQQCSRHGIGFDEEMQID-TPSGRKWVRMVEMLTKAL----EGLAVYFRDVSKRRK
SQEQLMLLETIVLIAEAQPA-RKKVPYIVFVNHAFEQHTGYSRHEVLGQTPHK--MGPGAAQD-EF-------------ELLIYRKNGSCFWLELEIVQV
ADTADDLAHWVAVGRDITQRKVAADAIHQLAFYDPLTSLPNRLMLLNRLEQVMSQSVDLRRNGALMFIDVDKLKVLNDTLGHHKGDMLLQQVAERLAGCV
DDTDTVARLGGDEFVVLLEDLGDAKTQKLAEKVLEQLREPFDLSGHQHYTTSSIGVTSLNGPHDSVSEVLKQADLAMYQAKTTGRNAVCFFDPEMQAVVN
ANAAVSSELHAGLRKQEFVLHYQPQVDR-QGCVTGVEALLRWQHPRRGLVMPADFIPMAEDSGLILPLGQWALATACEQLAAWAQWPQASLSIAVNVSVR
QFRHPDFVDQVMAEIRRTGIKPEHLKLELTETLLADGMEITLARMGTLKALGVTLALDDFGMGYSSLSALKRLPLDQLKIDKNFVAEVLTDRADAAISRT
IITLAHSLNLEVVAEGVETQAQQDFLIAQGCDQFQGFLFSEPLPIGELEAYLMEPG----
>tr|F5XYP7|F5XYP7_RAMTT Signal transduction protein : sensor, PAS/PAC domains regulator, GGDEF/EAL domains-like protein OS=Ramlibacter tataouinensis (s
---------------------------------------------------------------------SMSISHTLPTATLVSLLERSAHAGWWSLDAA
--QWTWSPQLARLHDVPAHG-TSTSDE-ALAFYAAPWRERIAGCVDRCCRDGIAFDEEAQIVTRQGRPLWVRVLELVTRAQ----GGMALRLADVTARRK
SQEQLRLLEGIVIITEAGPF-NAPGPRIVFVNEAFETRTGYGRDEVLGRTPRL--QGPETQRD-RL-------------DLINYRKNGEAFWVDLDISPV
WDKARKLTHWVAVGRDVTERKIAEEKIQYLAFYDALTKLPNRQLLLDRLQESLANR-HQTREGALMFIDLDNFKVLNDTLGHQKGDLLLQQVAERLRSCV
SKGDTVARLGGDEFVILLENRKDPGARSVAERILAALGEPYVLPGYLHHSTCSIGVTLFGKTPWTVSELLKQADLAMYQAKSAGRNTVCFFDPEMQAVAT
ANATLAADLRQAWRERQFQIDYQPQVGP-DGRMTGVEALLRWQHLQRGVVPPEQFIPIAEETSLIIPIGRWVLDTACAQLKAWENQPGRHLSIAVNVSVR
QFRHPEFVDEVMSAIKESGIAPHKLKLELTESLLADGIEVTVAKMGNLKAMGVALSLDDFGMGYSSLSYLKRLPLDQLKIDREFVKDVLTDANDAAIART
IIGLAQSLHLEVIAEGVETEAQRDFLARQGCHAFQGYLFCRPLPLQRLEAFIDAQL----
>tr|A0A011NPY7|A0A011NPY7_9PROT Bacteriophytochrome cph2 OS=Candidatus Accumulibacter sp. SK-12 GN=cph2_4 PE=4 SV=1
---------------------------------------------------------------------LANAAELR-------RAQRVAHVGSWIYDLS
SRIFGV-----------PEGSTGSLAG-FMKLVHPDDRGS-LQQYTEAALRGEPFDSELRIIT-DGGVRWVAQRETTLTRRQGQPQRIVVVSHDVTDRRQ
AEQWERIAA-AAFESEQGMFITDADGVILRVNQAFTAITGYSAAEAVGQTPRLLRSGRHDALFYAAMR----ATG----EIWNRRKNDEIYPEWLTISAV
NDSHGRVTHYVSMLTDITLRKATQEEIKQLAFYDALTGLPNRRLLHDRLRIAMAASARRERQGALLFIDLDNFKTLNDTLGHEKGDLLLQQVARRLSDCV
RERDTVARLGGDEFVVMLEDLGARQCRVVGEKILAVLNRPYDLGGHEYHNTPSVGVTLFDGQQDDIDELMKRADLAMYEAKAMGRNNLRFFDPRMQAVVS
ARAALERDLRQALQAGEFFLCYQPQVGL-DGRLLGAEALLRWQHAQRGLVPPGEFIPLAEETGLILPLGQWVLQTACAQVAVWSARAGRQFSLSVNVSAR
QLRQPNFVDQVLAALDAAGASPRNLKLELTESMLLDNVQDIIAKMAALKARGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDLLNDANDEAIART
IVALARSLGLEAIAEGVETLAQRDVLAGHGCHAYQGYLFSRPLPLADFEDFLERH-----
>tr|A0A011QW94|A0A011QW94_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-92 GN=gmr_1 PE=4 SV=1
---------------------------------------------------------------------QASEAELQ-------RAQAVARVGSWVLDLA
SRIFAL-----------PEGTTGSIAT-VTELLHPDDRQT-WQQASAMALAGEAFAVELRVQV-NGSERWIAQHETTLSKSRGQVSRVIVVSHDVTDKKQ
AEQQERIAA-TAFESQQGMFITDAKGVILRVNQAFTEITGYTSDDCVARTPKLLSSGRHDASFYSAMR----ETG----EIWNRRKNGEIYPELLTISAV
RDSDGIVTNYVSTLTDITTRKAAQEEIRHLAFYDALTGLPNRRLLHDRLRQALAASARRGRHGALLFIDLDNFKTLNDTLGHDMGDCLLQQVGKRLAACI
RERDTVARLGGDEFVVMLEDLGQPQSRTIGEKILAALNRPYDLDGREYHNTPSVGITLFGGGHDGIDELMKRADLAMYEAKATGRNTLRFFDPQMQAVVS
ERASLEKDLREALKRQQLLLFYQPQVDA-ASAVIGAEALVRWKHPQRGFVSPAEFIPLAEETGLILPLGLWVLETACAQLAIWAAQPGRRFTLSVNVSAR
QFRQPNFVDQVLAVLGGSGANPRQLKLELTESMLLDNVQETIAKMGTLKSSGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVQDLLTDPNDEVIART
IIALASTLGLAVIAEGVETAAQREALAAQGCHAYQGYLFSRPLPAADFDVFLAGA-----
>tr|C7RS22|C7RS22_ACCPU Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Accumulibacter phosphatis (strain UW-1) GN=CAP2UW1_2558 PE=4 SV
---------------------------------------------------------------------QAREADLN-------RAQAVANVGSWVYDLV
SRILGL-----------PTGTVGSLDA-FMARVHPDDRDT-LQQAAAAALRGEPFDNELRLVF-GETTRWITQRETTLSENQGEAARVVVVSRDVTERKQ
AEQWERIAA-TAFESQQGMFITDANAVILRVNQAFTDITGYAADECIGQTPKLLSSGRHDASFYAAMR----ENG----EIWNRRKNGDVFPEWLTISSV
RDGDGVVTHYVSALTDMSAHKAAQEEIRHLAFYDALTGLPNRRLLHDRLRVAIASSVRSERQGALLFIDLDNFKTLNDTLGHDMGDRLLQQVGQRLSSSV
REGDTVARLGGDEFVVMLENLGEPQSRIVGEKIIKLLNRPYDLSGHDYHNTPSVGITLFGGQQVGIDELMKRADLAMYEAKASGRNALRFFDPRMQAVVT
ARADIEKDLRAAVGRQSFFLAYQPQVDA-SGQVIGAEALLRWQHQQRGTVSPAEFIPVAEETGLILPLGLWVLETACAQAALWAARPGRRFTVSVNVSAR
QFRQANFVDQVLAVLARSGAHPRNLKLELTESMLLDNVQDIIAKMSALKARGVGFSLDDFGTGYSSLSYLKQLPLDQLKIDQSFVRDLLTDPNDEVIART
IIALARTLGLSVIAEGVESVEQQDALAAQGCLAYQGYLFSRPLALADFEAFLRR------
>tr|C5JAR6|C5JAR6_9BACT Conserved uncharacterized protein OS=uncultured bacterium GN=ao02_0240 PE=4 SV=1
---------------------------------------------------------------------RNAEVRLRESEERFRRLVEL------APDAI
-TIVYANRQAQIMMAPTPTDLIGRSI---IEIIDPACHDLVAKRLK-LLARGEQLPVEMRLVRLDGGQVEVE--TVWVSAAVGRWNFFSVAARDISKRKQ
SEEKLRHLSQAVEQSPADVVITNAEGIIQYVNPRFSQVTGYASKEVIGKKPSILKSGRTPAALYDSLW-----------ELMNRKKDGSLFWQHAIISPI
RDNSGVITHYISVKEDISIRKEYEERLVRQANYDALTGLPNRILAMDRLKQAIAQAQRYNRKVALMLLDLDDFKKVNDTLGHAAGDLLLKEAALRLVDCL
REGDTVARLGGDEFVLLLPDLTDSSAEVVAEKILAACNQPFDVGGHEAYIAGSIGIAIFPDDERDPILLMRNADAAMYRSKREGKGVFRYFTPEMNARAL
EHMRMESQLRHAIERNEMKVHYQPLVDSGTGRLVGAEALLRWSNPVLGEVSPEQFIPLAEETGLILSIGAWVLRTACRDAASWQRPDH-EIFVAVNISGK
QFQKRTLVEIVRSSLNESGLPPACLELELTESVLLEHTQETLSIIQELESLGVGFAIDDFGTGFSSISYLRRFPFDTLKIDRSFIKDLGDNEGDADLVKS
IIAMANSMSLKVVGEGVETHGQREFLRLSGCHIAQGWLYSRPIPGKDFQELIDGWT----
>tr|W6K8P0|W6K8P0_9PROT Chromosome, complete genome OS=Magnetospira sp. QH-2 GN=MGMAQ_1180 PE=4 SV=1
---------------------------------------------------------------------KNTQEHLNRIAS--EQEAVLQNASVGIARLV
GFLFGLGAA---SPGLSIAD----------LFYSPSDYAAMNRDAAPIHAENRTYRAELKLRRKDGTLFWCRFTRIFERILPKTPTSFFAFVTDITDRIQ
AEEILRLSAAVFENSADAIMITDANNHIKAVNPAFTRITHWPAEEVIGKDPAILNSGRHGSTFFNEML-----------EIWNQRKDGEEFAGWLSIAAI
RDDQGTMVEYVALFSDITKRKEAEEVIRRQANYDALTQLPNRTLFLERLRSGLVQAKRAERRIGLMFIDLDRFKWVNDTLGHAAGDQLLQQAAERLTGCI
RESDTVARLGGDEFTVILSQVAHRDVERVASKILDRLASMFLIDDTDVFISGSIGITVFPDDGDDVETLLKNADSAMYRAKEGGRNAFRFFTGEIDEKVR
IRLEMENDLRHALGAGELSVVYQPIIDLASDRISGAEALLRWAHPEKGPMNPGDFIPLAEETGLITQIGEWVLWTACTQVKTWQEAGLPIGRVSVNISSK
QCRQDNFEERVNQILDRTGLAPEFLTLEITETVILEDSSGSANVLNNLHDQGLHLSIDDFGTGYSSLSYLKRYPFDVVKIDRSFIDEVASDAADAALVEA
IITMAHGLDLTVVAEGAERQETVDFLKARDCDYIQGYFFSRPLPPADFEAFVEDWA----
>tr|F6DV35|F6DV35_DESRL Diguanylate cyclase OS=Desulfotomaculum ruminis (strain ATCC 23193 / DSM 2154 / NCIB 8452 / DL) GN=Desru_0822 PE=4 SV=1
---------------------------------------------------------------------IEVEKKLRL------AQKQLNSMIEFLPDAT
-KVIAWNRAMETMTGVKKEDMIGKGDA-YSLPFYNEARPMLIDFIFSDTFFDCTYDVE---NFFPGQYLWAK---SIIYLYKGEFAGYIGVCYDITELKS
TKEQVLKLSTAVEQGPSIVIITNTAGEIEYVNPKFTEITGYHYDEVIGKNPRILKSGKV--PLEKKLW-----------EFLNKKKSGELYWEYASISSI
RDSTDKITHYLAVKEDITERKKTGEKISFLAFNDTLTGLPNRTKFTEILANRLEATGSSINTISVLFIDLDMFKRVNDTLGHGAGDKLLVDVGKRLTAIV
DNQGIVSRMGGDEFTVLLELPHN-ALKEIVEKILHGFRKPWIIDDLEFYFTASIGVATYPGDGEDAETLLKRADTAMYWAKERGKNNYQFYTSTIQDRSL
RKVRLENHLHHALEQQELILYYQPQVHIESKEIIAVETLLRWIHPTMGLISPEEFIPLAEEAGLIIPIEKWVLKTACTQAGIWLKKNK-TLKIAVNLSAR
HFQQSSLIETITRTFEETKIDPTQLELEITESTAMKDPELTIKILNSLKSMGVSISVDDFGTGYSSLNYLKRFPLKKLKIDRSFISDITSDQEDEAIVST
IIVLAKSLHLEVVGEGVETKEQIAFLKRLGCSIVQGYYYSKPLPGTEIEKILSKGF----
>tr|D5CPV3|D5CPV3_SIDLE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sideroxydans lithotrophicus (strain ES-1) GN=Slit_0879 PE=4 SV=
---------------------------------------------------------------------KKAAAALR---L---QSQIVEN---AVEGIV
-TIQYTNRQFETLFGYAPGELIGKHIS-IINAPGNKSQMETAQEINRQLEKEGVWSGEVFNRRKDGTTINTFLNSYQLMRKSTTYGRCFVFSTDLTEQKR
AEESLRLAAMVYENSSEAILVTDADNLIIAVNPAFEQMTGYAAAEVLGKNPRIFKSGRHDRAFYHSMW-----------EVWDKRKNGEEYIKLLTINVI
RDDDGAIYRHVALFTDITERKKVEELIWRQANYDSLTKLPNRQMFHDRLEQEAKKAHRAGLSMALLLIDLDRFKEVNDTLGHDKGDILLIEAARRISACV
RESDTVARLGGDEFIVILSELEDASIDRVAQDILGSLAEPFKLDAEPAYISASIGISLYPNDATELDVLFKHADQAMYVAKYAGRNRFNYFTKDMQEAAQ
ARMHLANDLRIAVAAGQFRVYYQPIVEMSSGQIYKAEALIRWQHPVRGMVSPAEFIPLAEETGLIVPIGEWVFRQAVQQVVQWRRKFHRSFQISVNKSPV
QFRHAESLSW-PEYLEQQHVSGDSIIVEITEGLLLDAEVEVNKKLLRFRDAGIQVAIDDFGTGYSSLSYLKEFDIDYLKIDQSFVRNLGPGTSDLALCEA
IIVMAHKLGFKVIAEGVETSTQHELLAAAGCDYGQGYLYSRPLPPEEFERQLAGKL----
>tr|W6K925|W6K925_9PROT Chromosome, complete genome OS=Magnetospira sp. QH-2 GN=MGMAQ_1868 PE=4 SV=1
---------------------------------------------------------------------------------MARKQKSAKKTPTWMEQLT
SHVVEANKAALTRLGVTPEALLV---------------------------VGDDFD----SSLSDGRNRSLRLRAIAQA-K----KLFTALVRDITERRK
TEDALRLAQDVIEATSEGVVLTDPEFRVTSANPAFTRITGYSADEIMGKKPH-TKLKRD--KELAQML-----------EIWNKRKTGERYAQRLAISTI
HSEEGEIHQYAVLVSDITQRKQDEERIRYQANYDALTGLPNRSSFLQSLNQALLLGKRQERKVILMFIDLDGFKLVNDTLGHELGDLLLTQAAARLLDCV
RTSDTVARLGGDEFTICLTEICDYDAPIVAQRVIDSLSQAFILKGQEAFVSASIGITTFPDDAENATDLLKHADAAMYRAKEKGKDNFQYFTADMNEEVK
ERLFMKNGLSNALERQEFVLYYQPKMGLETDGLTGVEALMRWKHPEIGLVPPGRFIPVLEETGLVVDVGVWILQEACRQHVAWIEQGLPPIRVAVNLSAR
QLRDTALIGIFEQVLKDAGIGPESMEIEITESMLMSDHGPVIKVLGALHEMGLHVAMDDFGTGYSSLSYLKKFPIDTIKIDRSFVADIAVDKDDAEIIRT
IINMAQSLRRRVVAEGVEDAEQLQILRDYKCHEVQGYFFSPPMPAAEMNAYVLGLK----
>tr|K9GVF8|K9GVF8_9PROT Diguanylate cyclase OS=Caenispirillum salinarum AK4 GN=C882_0901 PE=4 SV=1
-------------------------------------------------------------------------SRLSA--ED--HAAIFAQSG-------
-GIVLAANHAFRLLRRPEEAIVG---S-FFDLLDPRERAALGTRLERLLA-G-PVRLE-RVRLIDGRRLWGALCVQLDRRA-ALVKVAVATIKDITERKR
AEDERRKLSSALDQAAAAVVITDARGVIDYVNDRFTALTGWTAAELVGRHASVADP--EA-PAEAF-------------EARAVRKDGEAYWETVSVAPV
RDDAGAVTHFVAVKEDITQRKETERRVWQQANFDAVTGLPNRVLFQDRLHQDLTRARRKDERLCLMFIDLDRFKLVNDTLGHEAGDELLVEVGRRLTACV
RESDTVARLAGDEFTILLPEPGTADIAAVAERVLAALRRGFVIAGGEVFIGGSIGISVYPDHGEDASTLLKHADAAMYRAKDLGRNTHCVYSEDLGAKAA
ARLELEGDLRRALGRGEIAVLFHPVVDAAERRVTGAEALVRWNHPTRGQLPPADFLPLAEEIGLIHDIGRHVLRVACTEAAAWRREVGEAPAVSVNVSDA
QLVQGRLADAVAEALAHSGLPPAALMLELSESVLLREEAAVGRGLDALSAQGVVLALDDFGTGYASLQHLRRYPFRALKLHRSFVRDMMGDEDDRRLVET
VIAMARALGLQVVAAGVEHPEQLAWLRARYCDSVQGYLFGQPLTSEAFRDTLRRPV----
>tr|K9DBI6|K9DBI6_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia timonae CCUG 45783 GN=HMPREF9710_04180 PE=4 SV=1
---------------------------------------------------------------------ARREEQFRTVTQVYRGGAI---------EFV
-------DEIEKITGYPSARFMCATTD-WADIVHPEDRRVYHRAVRDAALSGNAYEMEYRIIDAYGIERWVQERQIIVQERNRADEGSIWVFADITERKL
AEEKLRLSA-VLEHIADGVMVLDVHGRIVATNPAFTRITGYAEHEALGRASSLSSHDRNDPALYQELW-----------EIWDTRKGGDAYLEALTVSAV
RDDDGATTHYVCVFSDITRARESQIQLDHLAHHDALTALPNRLLYHDRLRHAMARAERDGEQLAVLFIDLDRFKNVNDTLGHHVGDELLKQAAQALSRCL
REGDTLARLGGDEFIVLLEDVDGRGATRVADKLMAMFEQPFEVSGHELFVTGSVGISLYPRDGHDMHILIRNADVAMYQAKARGRNGYRFYAPTMSGDGA
LRLRMEALLRRAIEKREIHLAYQPQVEIDSGRLVGVEALLRWNSPELGQVAPSRFIPLAEDTGFIGQLGQWVLQEACRQMVAWEAQGLAVPKIAVNLSVR
QFERGGMAAAVAAVLGDTGLAPQRLQLEVTESAIMNT-GDALQYVNDLHAIGVCLAIDDFGTGYSSLAYLKQLPVQTLKIDRSFIKDIPQDPDDEAIAIA
IIQLGKSMNLSVIAEGVEREDQAAFLLRHGCRLAQGYLYGKPLGHDEILARWGVTQ----
>tr|A0A085FFC3|A0A085FFC3_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Massilia sp. LC238 GN=FG94_02457 PE=4 SV=1
---------------------------------------------------------------------GRREEQFRTVAQVFRGGHI---------DFV
-------EAIEEISGYPAERFMLATTD-WANIIHPEDRRMQRHAARDALAAGSSYEIEYRIIDAGGIERWVLESQIIVRARARPNEGSIWVFADITERKL
AEEKLRLSA-VLEHIADGVMVLDVHGRVLATNPAFTQITGFTEMEALGQQSSLTRPGSHDDPLYGQMW-----------ERWETRKNGEGYLEWLTVSSV
RDDNDEVTHYVCVFSDITEVKQSQDKLDHLAHHDPLTALPNRLLFHDRLQHAMVRCTRAGQQLAVLFIDLDRFKNVNDTLGHHVGDLLLKQVAGQLAACL
REGDTLARLGGDEFIVLLEDVGGQGAAHVAEKLMALFEQPLTVSGYELFVTGSVGISVFPQDATDLNMLIRNADVAMYQAKARGRNGYQFYAPSMSGEGA
MRLRLESLLRRAIEKGEIFLEYQPQVEIDTGRLVGVEALVRWDSPELGRVAPVRFIPVAEDTGFISQLGQWVLAEACSQMRRWDRDGLAVPKMAVNLSVR
QFERGSIAPVVAAVLQETGLAAGRLQLEVTESVIMNT-SDALQHINELRAVGVGLAIDDFGTGYSSLAYLSQLPVQTLKIDRSFIQDILVDANDEAIAVA
IIQLGKSLNLSVVAEGVENEEQAAFLLRHGCRQAQGYLYSRPVAAGDILSRWGRAQ----
>tr|A0A098U9C3|A0A098U9C3_9BURK Diguanylate cyclase OS=Massilia sp. JS1662 GN=IA69_14110 PE=4 SV=1
---------------------------------------------------------------------GRREERFRTVSQVFRGGLI---------DFV
-------DAIEDISGYPATHFIGAHTR-WADVICPEDRKMQRHFVKEAVLGVRPYEIEYRITDAAGIERWVLESQIIVDARERQDDGSIWVFADITERRQ
AEEKLRLSA-VLEHIADGVMVIDLHGKIVATNPAFTQITGFTESEAVGTHSSLTRLASDDAGISEALW-----------ELLNRRKNGETYLEWLTVSAV
RDDADAVTHYVCVFSDITKVKESQDKLDHLAHHDPLTGLPNRLLFHDRLQHAMVRAARSHRQLAVMFIDLDRFKTVNDTLGHHVGDELLKQVAGQLSGCL
RDGDTLARLGGDEFIVLLEDVDGHGARQVAEKLMQLFERPVLVSDYELFVTGSVGISLFPQDAVDMNMLIRNADVAMYQAKARGRNGYQLYAPSMDGDGA
ERLRMEGLLRRAIERGEIRLHYQPQVEIETGRLIGVEALVRWHSAELGHVPPVRFIPLAEDIGFIGQLGAWVLEEACRQVVCWEAAGLYVPKVAVNLSGR
QFDRGSVAPLVARVLADAGLAPQRLQLEVTESVIMNT-GDALQYINDLHALGVELAIDDFGTGYSSLAYLKQLPVQTLKIDRSFIKDIPADKDDEAIAVA
IVQLGKSMDLAVIAEGVETAEQAAFLLRHGCRRAQGYLYGRPVEPAELLETWRQDD----
>tr|A0A031GWL2|A0A031GWL2_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Janthinobacterium lividum GN=BW37_01433 PE=4 SV=1
---------------------------------------------------------------------GQREERFRTVTQVFRDGPI---------DFV
-------DAIEDISGYSARQFMRGTTA-WADLICPEDRREHRRAVGQAVLDERPYALEYRIVDAFGIERWVAENQIIISARLRPNEGSIWVYADITARKE
AEEKLRLSA-VLEHIADGVMVVDADGIIVTVNPAFTQITGYAEAEALGQHASLTRSERHDAAFYQSLW-----------EIWNRRKNGEVYLEWLTISAV
RDTRAVTTHYVGVFSDITLIKESQEKLDHMAHHDPLTALPNRLLFHDRLQHALLRAARDQEQLAVLFIDLDRFKNVNDTLGHHVGDELLQKVAGQLAARL
REGDTLARLGGDEFIVLLERIDGYGATQVAEKLMTMFDQPFTVAGHELFVTCSVGISLYPDDALDLNMLIRNADVAMYQAKARGRNGYRFYAPSMTGEGV
ERLRLETFLRRSIEKNEMFLNYQPQVEIDTGRLVGVEALVRWNHPELGLVPPARFIPLAEDSGFINQLGKWVLDEACRQMMRWQAQGLHVPKMAVNLSVK
QFERGSIAGMVAAILKETGLEPQRLQLEVTESVIMNT-GDALGFINDLHAIGVGLAIDDFGTGYSSLAYLKQLPVQTLKIDRSFIKDISTDVNDEAIAIA
IIQLGKSMHLSVIAEGVETEEQAAFLLRHGCKLAQGYFYSRPVLAQDMLERWIDHS----
>tr|W0V4G2|W0V4G2_9BURK Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628, complete genome OS=Janthinobacterium agaricidamnosum NBRC 102515 = DS
---------------------------------------------------------------------GQREERFRTVTQVFRDGPI---------DFV
-------DAIEDIAGYSARQFMRTTTA-WADLICPEDRKMHRRALKQAIIDNQPYEMEYRITDASGTERWVAENQIIVRAKQRAYEGSIWVYADITARKE
AEEKLRLSA-VLEHIADGVMVIDAKGMIVAVNPAFTQITGYTESEAVGQDSTLTRSGRHDEAFYHDMW-----------EIWNLRKNGEIYLEWLTISAV
RDTQGVTTHYVGVFSDITLIKESQEKLDHMAHHDPLTALPNRLLFHDRLHNALQRAARDNEQLAILFIDLDRFKNVNDTLGHHIGDELLKQVAQELMGKL
REGDTLARLGGDEFIVLLEDVDGYGATHVAEKLMTMFETPFVVADHELFVTCSVGISLFPNDAVDLNMLIRNADVAMYQAKARGRNGYRFYAPSMTGEGV
ERLRLETFLRRSIEKNEIFLNYQPQVEIDSGRLIGVEALVRWNHPELGLVPPVRFIPLAEDSGFINQLGKWVLFEACRQMIRWQNAGLYVPKIAVNLSVK
QFERGSIVNMVAEILAETGLEPQRLQLEVTESVIMNT-GDALAFINDLHSIGVGLAIDDFGTGYSSLAYLKQLPVQTLKIDRSFIKDISTDVNDEAIAIA
IIQLGKSMNLSVIAEGVETAEQAAFLLRHGCKLAQGYFYSRPLLAQDVLLNWTA------
>tr|H0Q2F8|H0Q2F8_9RHOO Uncharacterized protein OS=Azoarcus sp. KH32C GN=AZKH_4544 PE=4 SV=1
---------------------------------------------------------------------NQLPQGISV----------------FDEH--
-RLRYWNQGLAEVLDLPPELLRPGVGF-DELLMVP-------ALRGEY-GPGDPAEPHRFRARPNGRTHLVD--ETYMGARQ---GGFVTIYTDISARKR
DEERLQLADKVFENSPEAIVITDLSQRILSVNPAYTAITGVAAQEAQGMLFRPEESDSLG-GS-IAVW-----------ETRGQRRDGNYYPRSLTITGV
RDPTRQLTHFIAMFSDITERKRAEADIQQLAYQDTLTGLANRFSLSARLQQSVADARRNGQQLAVVFLDLDRFKHINDSLGHAVGDELLRQVALRLRGAV
REVDTVARLGGDEFVVVLQSINGNDAAHVAAKLLKQLSAPYVVQGTELHTTPSIGLSLFPDDSSCPDALMRNADTAMYHAKAAGRARFQFYTEEMNQAAT
ERLDLERKLRGALKRGEFELWYQPQFASADGRLTGMEALIRWRHGEDGLIPPVRFIPIAEETGIILDIGNWVLGEACRQARAWLDEGLPPLRMSVNLSVR
QLRDATIVDTVKHALADSGLDPSLLELEITESSVMERPGEAIALLQHLKDLGLQLAIDDFGTGHSSLSYLKLFPLDHLKIDRSFVSDIEHDANDAMIVAA
AVSLAHNLGLTVIAEGVETPVQIERLRELGCDELQGYLFSKPLPVAEAGAYIREHN----
>tr|Q5P4Q9|Q5P4Q9_AROAE Azoarcus aromaticum EbN1 complete genome OS=Aromatoleum aromaticum (strain EbN1) GN=ebA2811 PE=4 SV=1
----------------------------------------------------------------------HRPRCTSRSRARLRYGCHRERHPGNSRA--
-HCRFWHRSADA---------------------------------------G---GSRRREAPAAGRLS------ADVSARQ---GGFVTTYTDITARKR
DKERLQLADKVFENSREAIVITDLGHRIVSVNPAYTEITGIAATAAQGTCFRPGSDDGDSGEEGRTVW-----------ETTGVRCGGQRYPRTLMINGV
RDPTREITHFIAIFSDITARKRAEADIQHLAYHDTLTGLANRFSLTARLQLSVAEARRNGQRLAVMFLDLDRFKHINDSLGHPVGDELLKQVARRLRDAV
RETDTVARLGGDEFVVVLQGIGGHDVTHVAAKLLAQLSAPYCVDTTELHTTASIGISLFPDDSADPAALMRNADTAMYHAKAAGRAKFQFYTDEMNRAAT
ARLDLERKLRGAVARGEFELWYQPQFDSRHGHLTGLEALVRWRHPQDGLIAPLRFIPLAEETGVIVEIGTWVLREACRQARQWLDAGLPELRISVNLSVR
QLREKCLVDTVWTTLAASGLRPGLLELEITESAVMDNPDEAVALLQALKNLGVRIAIDDFGTGHSSLSYLKLFPLDHLKIDRSFISDIEHDANDTMIVAA
AVSLAHNLGLSVIAEGVESAVQVARLRELGCDELQGFHFSRPVTADVVENLLRSVW----
>tr|F5UP40|F5UP40_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Microcoleus vaginatus FGP-2 GN=MicvaDRAFT_0319 PE=4 SV=1
---------------------------------------------------------------------PQGEKVLQPKQQIAQMTQDLQQTAEYALDIC
EHILSLNQATCQLL--SKKELLGQPIG-LFKKTSPPPELE----LASLTAEGAVRN--VQVYISKQRKKIIVLLSIARLAK----ASILITAFDISDRKL
AELELETSFSTIESTADGILAVDSTGKVLTFNRKFAEMWQLPD-FLLD-SRNQWGFGINQLKYPAE------SDGCWSEEYSFHRADGGYIFVLDRGYII
RNESGKAVRAIGTMMDITQRKQAEEIIRYQAVYDQLTGLPNRILFNERLLASLREAKKTQKMLAVMFLDLDRFKKINDTLGHAAGDRLLEGFAGRISDTL
RSTDTVARWGGDEFTILLSDINCEDAVKTAQRIFNNLKPAFKLEGQPFHVSSSIGIALYPDDGEDAETLVKNADSALYRAKEMGRNNYQLYTSTINPQCS
QLLTIEHRLHEALEQGEFEVFYQPKVNITTWKIQGMEALLRWQHPQLGLVTPATFIPIAEENGLIVAIGEWVLQTACTQNKAWQDALQPDLRVAVNVSAR
QFQQFNLLEMVANCLDKSGLAPKYLELEITETTAMQDVDYTTKVLRELQNMGVQIALDDFGTGYCSLNYLKKFPLNILKIDKSFVSGLTTDPCERAIAKA
VATLGRDLNLSVVAEGVETKEQLECLRELHCQEIQGYYFSPALSAGEASKVLGNSM----
>tr|B0UG16|B0UG16_METS4 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacterium sp. (strain 4-46) GN=M446_3902 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------MLL------------ACRP-P----GGAVRTYTDITDRKR
AEQQVAASEALADGLPQMVWVRASDGELLYRNARFAHYYGEIGARVERSHPEIVRLRRHDGVHRLFDW----PTGSYECEQRMRRKDGGWAWILERGKVV
SRADGTARRVVGTHIDITARKEAEARVTHMARHDTLTDLPNRALFRERLEQRLAEIRRHGGHCVLLALDLDAFKAVNDSLGHLAGDALLREIARRFRSVL
RAEDTVARLGGDEFAILLGGTPRESVMDFAERLVASVREPVTLEGQQVGVGVSIGIAIGPEHGEDADTLFRHADRALYRAKSDGRNTFRFFEPAMDRAAE
ERRRLELDLQLALRRGEFVLHYQPVLDVASRAIVAVEALVRWNHPTRGQLGPGVFIPLAEETGLIVALGEWVLRTATRDARHLP----EHVRVAVNISAV
QVRHASLGQTVRAALDAAALSPDRLELEITESVLMGDSSLVRDALSGLRELGTHLALDDFGTGYSSLSYLRQYPFDRLKVDRSFIASIPD-QGTVTILRA
IVGLGTGLGMTVTAEGVETPAQFAFVEAEGCAQVQGYLTGKPQPLPDLLATLEGRN----
>tr|B7KTR4|B7KTR4_METC4 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylobacterium extorquens (strain CM4 / NCIMB 13688) 
---------------------------------------------------------------------RRAEAHLLEWEAAHAMAEQIAAFGHWRIDAG
TRTIAWSDGIARIFGRNAERATLPLET-HIGFYHPDDRERVWAAMDEALALGGGYE-HRSILRPDGEIRVVAVH-VCQV-P----GGHICTFTDLTASRQ
SEAALRSAEALFQNAVIGVYRRLDGG-IVQANRAL---------------------AR---LHGDA-----------------RHAGGERIWVSETAWV-
VRDAGRPIWFEGTVADATERKRAQALIEHMARHDALTGLPNRRLFQETLAREIDGARRDGGSVVVLCCDLDRFKAVNDTFGHPAGDALLRVIAGRLRATL
REGDVVARLGGDEFAIILPSRGKRRIAAFARRLIQAAGRPVDLGGRATTVGVSIGVAVWPKHGDSADTLFKNADIALYRAKDSGRNTFRFYESGMALAVV
TRNLLEIEMRESIRSGGFALHYQPIFALADGAPQGFEALLRWNHPLRGPISPGAFIPLAEESGLITQLGAWALHEACREAASWP----GDLRVAVNVSAV
QFRKTGLEQSVMRALAASGLPAGRLELEITESVLMQDSDAVIGSLHRLRAMGVRIALDDFGTGYSSLSYLCRFPFDKIKIDRAFIRDIDE-PVAAAVVRA
VVGLGERLGMAITAEGVETEEQLVQVRRKGCTEVQGFLLGRPLPAAEAMTLVAGRV----
>tr|I2QJL0|I2QJL0_9BRAD PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Bradyrhizobium sp. WSM1253 GN=Bra1253DRAFT_04718 PE=4
---------------------------------------------------------------------VE--AELRVTER---SQHALANMSHG-----
-RVVVCNERFLKLYNLDADIVKPGVT---------------GATIDHWLSSADEFHKTLLVMRYDGR--------VHRTASSV-RGGFVSTYEDITEREH
AVEELSEQYRALNNMSQGLCMLDSSLRVIVCNRRYIEMYGLSP--------ELVKPGVSMREI-ME-----------YADYVERLREGEHYLGDGRIIKL
NHKRMEHGGWVVTYEDVTERHKAQARVAHMARHDSLTDLPNRTLFREKMGEGLNQVAIAGGAMAVLCFDLDNFKTVNDRLGHAAGDRLLRWVAAQLQENV
GEHDTVARLGGDEFAVLQRGPQP-SAERLARRLVEIIGHPPPLEHQSMHVGVSVGIAIAPDHGLDADELMKCADLALYQAKAKGRGAYQLFEPEMEKEAR
SRHALEHDLRGALEAREFHLAFQPQVRLDTTELTGFEALLRWKHPSRGLVSPAEFIPIAEENGLIVPIGEWVLRTACATAATW-----PDLTVAVNLSPV
QFRSRGLVAMVTSALAEAGLPPHRLELEVTETALLDDSEATIEILHQLRALGVRVSLDDFGIGYSSLSYLRKFPFDRIKIDRSFVGTLSESPESMAIVRT
IASLGSVLNVETTAEGVETIEQLDFVRECGCTAVQGYYFGKPSPAAEVVRVIERLN----
>tr|I0GGZ7|I0GGZ7_9BRAD Uncharacterized protein OS=Bradyrhizobium sp. S23321 GN=S23_68580 PE=4 SV=1
---------------------------------------------------------------------LE--AELRLTER---SQHALANMSHG-----
-RIVVCNERFLNLYDLDPNIVKPGVA---------------STAIDHWLSPGDKFRKAVLVTRYDGG--------VHRTAVSV-RGGFVATYEDITEREH
AVEELSEQYRALNNMSQGLCMLDSSLRVIVCNRRYIEMYGLST--------DIVKPGVSMREI-ME-----------YADYVERLREGEHHLSDGRIIKL
NHKRMEHGGWVVTYEDVTERHKAQARVAHMARHDSLTDLPNRTLFHEKMGDGLNQVATAGGAMAVLCFDLDNFKTVNDRFGHAAGDRLLRWVATRLKENV
GEHDTVARLGGDEFAILQRGPQP-SAEKLASRLVDIIAQPLQLENQSVHVGVSVGIAVAPDHGLDADELMKCADLALYQAKAKGRGAYQLFEPEMEEEAR
RRHALEHDLRGALEASEFHLVFQPQVRLDTTELTGFEALLRWKHPARGLVSPAEFIPLAEENGLIVPIGEWVLRTACATAAPW-----ADLTVAVNLSPV
QFRSRGLVTMVTSALAEAGLPPRRLELEVTETALLDDSEATIEILHQLRALGVRVSLDDFGVGYSSLSYLRKFPFDRIKIDRSFVGTLGESPESVAIVRT
IASLGSVLGVETTAEGVETIEQLDFVRACGCTAVQGYYFGKPCPAAEVGRAIETLN----
>tr|A0A0A6QXV6|A0A0A6QXV6_9GAMM Uncharacterized protein OS=Methylomonas denitrificans GN=JT25_17820 PE=4 SV=1
---------------------------------------------------------------------KQSEQRFRDVESYFL------HDTDCTFTYL
-------PSVEHILGYTPEELRRDC---FD-ITTDNPINRIARMYELCLTGTKPPNYEVEVRCKDGSLRLLSLNSLAMSAAQNQPVRMLGTHTDITDSKM
AAERLNLLA-VFENSGEAIFLCDPDTRIVSSNQAYTNITGYRAEEVLQRTPSILDARHLELSHYQRIW-----------EIWDTRKNGESYPAWLGISAM
YNTHGVISHYIGIFSDITERKAAEAQIEYLARHDPLTNLPNRTLLRDRFDQAMAHAVRNATLVGLLFLDLDHFKNINDTMGHDVGDRLLQGIAERLVQCV
REVDTVCRQGGDEFIIILTDIPDEAITQIVLKILDQLTQPFSIEGVTVCTSFSIGVSLYPNDGLTFHSLLNKADTAMYSAKNEGRNTFRFFSNDMNLASI
ERMNIENGLRLALKRNEFRLHYQPQYSIHNNTVIGAEALLRWQPENSPMIPPAKFIPIAEDNGLIVSIGDWVLREACRQNKVWHDAGLK-LLVTVNISAL
QFKRGNLLESVQAALNDSGLEPRYLELELTESVLMFDTNAVINTIAQLRALGVSFAIDDFGTGYSSLSYLKRFAVNKLKIDQSFIRDLTSGKEDTAIVKA
ILQLGDTLGLLTLAEGVETKEQAEQLSLLGCRKAQGFYWNQPLPADEFARLFTPDS----
>tr|K9D8U8|K9D8U8_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia timonae CCUG 45783 GN=HMPREF9710_05059 PE=4 SV=1
---------------------------------------------------------------------LRADPALRA----------------------
-RVIF-----------------------FSAVYSERETMAMAARCGVTTVLGKP----------SEPQRILAAVES--H--LNLYRHAAQLQLEALARAD
ADAALRDSEHVFDSTQEAILMTDADANIVAANPAFEEITGYREAEVMGQNPRLMKSGRHDDAFYAGMW-----------EIWNRRKNGEIYPASMSISAV
HDEQGRRTAYVSVSTDLSALKAAHHQLDFLSNHDALTLLPNRSLFNDRMQQALAAARQDASQVALLLFNVDRLSRINDSLGHAAGDAVLREVARRAGEVA
GPTETVARLSGDEFVLLLTGFDDDDVIYCARRLMEAVSQPLLVGEHDVVVTGSIGISVYPRDGDVPGDLLKAADAALAHVKESGRNGFRFFKGEMNAEAL
RWLALETRLRRAIERDELSLHYQPQVSRLDGRVVGMEALLRWRSEEIGPVSPADFIPLAEDTGLIHPIGEWVIRQACFQNKAWQNAGLAPVRVAVNVSAS
QFKAGSVAQVVRTALHDSGLEAQWLEVELTESVMLGDSAAAEAQMAELRALGVSLSLDDFGTGYSSLGYLSRFPLDKLKIDQTFVRNIATEQRSAAIAQA
TIALAQGLSLAVVAEGVETVGQRDFLGSLGCDVLQGYLYGRPVPAFEMAELLAKGR----
>tr|D5CLV3|D5CLV3_SIDLE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sideroxydans lithotrophicus (strain ES-1) GN=Slit_2321 PE=4 SV=
---------------------------------------------------------------------------RR-------EAERLQRINATVFDSS
ANIISVNPAFTQITGYSPEDVLGKNPR-ILS-SGQQSKGF-YRELWEALLRDNFWQGELVNRHKNGSLYNIHLSSVTIMTKHG-KPALFNSSRDITERKK
IEVEIQIAA-TAFEAQEGMLITDADRNILRVNRAFTDITGYSAEEVIGKNPRILSSGLHDSHFYAAMW----VTG----EIWNKRKNGEVYPERLAITAV
KDARGVVINYVASLSDITLHKAAEDEIRSLAFFDPLTGLPNRRLLMDRLQQALVASSRSGKAGALLFLDLDNFKNLNDTLGHDIGDLLLQQVAQRLKNCV
REGDTVARIGGDEFVVMLEDLSASQTEAVGWKIISTLNKPYHLEKFEVHSTPSIGATLFDSRPQIIDDLFKQADIAMYQAKKAGRNTMRFFDPQMQDTLN
TRTALEADLRKSIERREFNLFYQIQVDE-MNRPVGAEALIRWIHPKRGMVSPAEFIPLAEETDLILNIGLWVLQEACAQLKTWQNNPLTNLVLAVNVSAK
QFRQSDFATQVRVFVEKYAIDPSKLKLELTESMLQENIEDTILIMNALKEIGVQFSLDDFGTGYSSLQYIKKLPLNQLKIDQSFVHDLDFDRDDKAIVRA
IIAMAKSLQLDVIAEGVETQEQRQLLLNKGCTHFQGYLFSKPLPIREFDALLERAI----
>tr|S5TZM4|S5TZM4_9GAMM Putative signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Cycloclasticus zancles 7-ME GN=
---------------------------------------------------------------------HTNETNLTKYNQSLSTKLAIQAIDLKASEIK
YKLIDCNTTCLKLLCHHRDQFIGTKID-WSATTQPNGS------------KSTLTAITLALREQKQSFEWNLKKETVLF--IELFSFYVKLIEIAIQRYE
ANKQ------IFQHSVEAMLLIDKDYKIITANPSFTTVTGYSVEEVIGKTPHILRSGRHDEKFYDKMW-----------EVWHKRKNGEHYTEWLTITTI
YDDNGEVLQRAALFSDITEKKKMDELLIKQANHDSLTKLPNRNLLKTRISEEITKYHRTKIPFAVLFADLDHFKEVNDSLGHDLGDLLLIDAAKRISECV
RETDLLARLGGDEFTIVMTDLNNHSVERVANAIIESLSRPFKLDTEIAYVSASIGIAFYPDDGDSIVDLLRHADQAMYYAKAQGKGRFCYFTKTMQENAN
YRASILNDLRTALPSNQLELYYQPIISLRTNTVIKAEALLRWNHPQRDIISPLQFIPIAEESGLIIDIGDWVFQQALAQLKHWRQHFQADFQVSINKSPV
QFKSLSQHADMDTLSRESNYPEPGLVVEITESLLLQEDPNIMLQFKQMQHNGVKLSLDDFGTGYSSLSYLNKFGFDFLKIDKSFTQEIVENSDKRELCNA
IIVMAHALGIEVVAEGIETLAQQDLLSEMGCDYGQGYLYSKPVPVKKFEQILKNGL----
>tr|F5RD43|F5RD43_METUF Uncharacterized protein OS=Methyloversatilis universalis (strain ATCC BAA-1314 / JCM 13912 / FAM5) GN=METUNv1_02202 PE=4 SV=1
---------------------------------------------------------------------RHALSRLRTADADRRFRVLFEKIAD------
-VFTDWNPAALRMLYPDRAQVIALRPD-ISPECQPD---------------GRPSAIEMMIARREGSFEWVIRSETWVGERDGLPLRMVGTHTDVTERRR
VMNDLAQSELLLDAMADGVF-VAQDFRFVFANTALPRILGYSRDEFIGLHFV---------VHPLELW---------RYEVQFMHKNGQ-RPVWIELIAS
RFVHEGDPAVLGIVRDISEKKINEQMIWRQANYDALTGLPNRHMLIHRLDQEMKLCQRHSWSLALLFIDLDRFKEVNDTLGHALGDRLLKQAAQRISGCL
RETDVVARFGGDEFTVLLGAIEQEVIEAIAAKILDRLHQPFQLDQHMAYVSASIGITLYPGESDSVDDLMMHADQAMYEAKRAGRNRVSYFTRSLQDDAE
RRMRLVADMHAAIEQAQFSLVYQPIVHIASGKVRKAEALIRWQHPERGHVSPADFIPIAEETGLILPIGDWVMRTGIKFARDLQARLGETVQISLNKSPV
HLRNRKPGYPVVELLAEYGVSGSLIAVEMTEGMLIEADEQTLQRLYALRDAGVQVSLDDFGTGYSSLSYLKKFDIDYLKIDQSFVRGLSAHSSERALCEA
MIVMAHKLGIEVVAEGVETHEQLALLREAGCDYAQGYLFSRPLPAEHFEVWLRENG----
>tr|G4SY12|G4SY12_META2 Putative Diguanylate cyclase OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) GN=MEALZ_2638
---------------------------------------------------------------------RTALDKLHKHSLIELQQEETERLQGYVSQMI
GTIEHTETELYVLLGHGLSAILPALN-------IPKK-------FREL--AGRGFS-------------------IK-SKMSGIE--------PGPGRVA
QVEAMLDLENVFMASPLAISITDHNRNIIAINPAFTAITGYTFAEVEGCNPRILSSGKHDSEFYRQMW-----------EIWNRRKNGELFLEWITVNAI
RDEEGTLTHYASVFSDITQRAVAEDKIRYLAHHDPLTGLPNRVLMLDRLNTAILQAQRDRSQLAVICLDIDNFKTVNDTLGHGFGDELVKDFAQSVLSSI
RESDTLSRLGGDEFAILLPRISSEAAARLADKIFHAVKKTYRLAERELHISFSMGISLFPDDGDNTEALLKHADSAMYLAKNKGRNNYQFFNQKLESQAE
RYMLIQHGLHRALKLKEFYIHYQPKFALDSSLIVGAEALLRWRSPTLEDITPAEFIPIAEETGYIVDIGCWVIEQVCQTLAAWKATGINLVPIAVNISPI
QFHRGNIKKALLKSTINHRLDPSLLQIELTEGVVMSGQQKTVQQLQELKDLRFSISIDDFGTGYSSLSYLRELPIDELKIDRSFIMEISDNPHLTAIPCA
VIDLAKNLGLNLVAEGVETEIQSRFLMQKGCNVIQGYLFSAPVDKDRMWELLKEYS----
>tr|G0A1P1|G0A1P1_METMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomonas methanica (s
---------------------------------------------------------------------SIATEKLGSRMIVSDYRYQEQRIEHYVTQLV
GCMEAVKDSLYVMLGHGLAAILPAMD-------LPRR-------FREL--AANGFS-------------------LC-QDGSGMT--------SWQSRPP
LVENLMSLQNVFMTSPLAITITDKNRNFVSVNPAFTKITGYTDTEVLGCNPKILSSGKHDGDFYRKMW-----------EIWNRHKNGELFLEWINISVI
RDENGEVCNYASVFADITQRLAAEEKMRYLAHHDYLTNLPNRLLLNDRLNQAILKAQREGAVLAVIYLDIDHFKNINDSLGHAVGDELILSVAQALQSVV
REVDTVSRLGGDEFAILLPDVGSKMASRLVAKIFMAASRTYQIAGRELRITLSMGVSLFPKDGENPATLLKHADSAMYLAKKEGRNNFQFFDEALENQTE
RYMLIQHGLHNALKRGELSIHYQPKYALDEKNIVGAEALLRWSSPELGVVSPAEFIPIAEETGFIVDIGCWLINQVCKTMAAWREQGATLAPVAINVSPI
QFHRGNLHRTLSQAMNSYLIDPALIQVELTEGVVMNKQHSTIELLHSIKGLGVAISIDDFGTGYSSLSYLRHLPIDEIKIDRSFIMEIVDDTRLTAIPLA
IIDLARNLNIKLVAEGVETEVQSKFLLENGCHIIQGYWFSKPVDDEAMLDFWLRA-----
>tr|F9U7I9|F9U7I9_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_0891 PE=4 SV=1
---------------------------------------------------------------------AALEERLTRSERLVEETQRLGHLGTWTWDAE
NDRLEWSAEVYRIFAVPPQSFPGNYKG-FLDCVHPDDRARVEHAVRAAIVGNLDYDCEHRILLPDGAVRYLHERTTVV-DA----AVALQQVRDRAARIA
----------LLEATGEGVFGLDPDGVTTFINPTGARLLGYDPNELVGKPCATDAADEGDR------D-------IVVSDEILQRRDGTAFPVEYRATPI
RVG-DSATGVVVTFHDITERKRSEEQILRLAYYDSLTGLPNRTLFKNQLAKRLTSVRRADKGFALHFLDLDRFKEVNDTLGHPVGDLLLKEVAQRLSSLV
RGMDTVARFGGDEFAVIQPDAQSSDAATLAAKIVEHLSRPYSIDGHAVTCGASVGVVFVPKPDIDLETLLGRADVALYKAKNNGRGSYAFHTDAMTRQVR
RDAALTDRIDQAVRSGELFLHYQPQVELASGRITAVEALVRWRHPVEGILPPGDFVHLAERRGLFHVLGSWVLSTAAREARRWHDQGLAFGRVSINVSPQ
QVRAGCLADDVLATAEETGLDPARLELELTETAMMEYGEHYRTQIAVLRDLGVRLVLDDFGTGFSSLTYLRRSAVSTLKIDRQFVLELDDNTDAVETVRA
LLAVAQALDLDTVAEGVETREQAARLAAMGCRCAQGMWFAPPMEANAIERHLREGF----
>tr|A1WT40|A1WT40_HALHL Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halorhodospira halophila (strain DSM 244 / SL1) GN=Hhal_0057 PE
---------------------------------------------------------------------KRIHQALLEREEQLHRLFENMTEGVLVVTPD
GTVRYANPSAANLFARDSTALIGAV---IGLPIGGPDAQ----------------EI--GLRSPAGELRTVEMRVREIRW--HEQPAHLLNLRDVTERKH
IETELRRAAIVFEEAHEAILVTDAEQRVITANPAFTEMTGYTEQEVLGKDLALLRSGFHDESFYTAIDDALAKQGYWTGEMWNRCRDGTTFATLVTVRAI
YDDAGHLTHYLAVLADISRLKEYQSQLERIMHSDPLTGLPNRLVFQDRLHQALVANQKQTGFFAVLSLDLNDLKAINYSLGHAVGDAILQQLAERLRNAL
CEEHTVARLGGDEFGVLLLGVRDSEVAAITEDLSKGLDEPFQIADRAIPIAASIGIAVYPEQDAGAADLFQQANAAMHQAKREG-VSYRFFSEDLTEQAR
ERVQLGSELREALNQGALELHYQPQIDLSSGAWVGLEALIRWHHPVQGWISPERFIPVAERIGLVTTLGAWVLEQACRQGRIWLDAGFEFGRLGVNFAAP
ELSAPDLAERVLAALDRARLPARYLEIEVTERLLVDPDPEVIQQLQLLRNHGVTVALDDFGTGYSALSYLRDLPVDRLKIDRSFVDGLPDDERTLAIAQA
IAGLGRNLGFTIIAEGVETPAQREALIGIGCPWAQGFLFGRPAPVAGIEALAPH------
>tr|A1WTX5|A1WTX5_HALHL Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halorhodospira halophila (strain DSM 244 / SL1) GN=Hhal_0343 PE
---------------------------------------------------------------------SVAESRAREREHQLDRVLSNTAEGILVVDEH
GRIVYANATAGTLTGHSPAELIGQD---FGFPVATGSPA----------------EI--ELHTSGNGNRIVEMRARTMRW--EGKPAFVLNLHDVTERKR
VERELRQAAIVFEEAREGVIITDAEANIVAVNHAFTQITGYDEDQALGCNPRFLASGFHTPAFYQAMWEAIRSHGYWTGEIWNRRNDGTTFAELATIREL
RDESGRPTHYIGVFSDISRIKEYQTQLERVLHLDPLTELPNRLLFHDRLEQALRQHQRQRNAVAVLVVDLSDFRAVNDSLGHAIGDRTLRIVGERLDSAM
GDSATVARLSGDEFGVLLPQLATDDAASAAERLIEAAEAPLEIDGHQIPITLRVGLSTFPDQAQGANVLLEQADAAMYEAKSEG-VSYRFFSEELTERAR
ERIELGAELRQALAGEELALHFQPQVDLDSGRWIGLEALLRWPHPRRGPISPGRFIPVAERTGLMCQLGAWVLQRACRQYQTLLDAGQDWGRLAINITAP
ELADPTFVERVMRTLEETGLAAERLELEITESLLVNTDERIIERLDALRRHGVRVAVDDFGTGYSALSYLKDLPVDRLKIDRSFIDNVDQPSRGATITRA
ILALGQSLELEVIAEGIETEAQRRTLQEAGCLQGQGFFLARPAPLEQLRPPDPA------
>tr|Q31M30|Q31M30_SYNE7 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Synechococcus elongatus (strain PCC 7942) GN=Synpcc7942_1859 PE
-----------------------------------------------------------------------ILSLVQDSETRFQVLIESNPNGILVLDEQ
GAVLFANHVAEQVFDQSLSELQGKY---LGLPLTLNVTV----------------QL--DLVQPDGSLRYVEVSIVPIPW--QQSKAYLALLTDITSLQQ
TQQRLKLLQEATENSPASILITSAEGIIEYVNPAFELMTGYGADEVIGKNPRFLKSGLMSPSFYQDLWETITAGETWRGELYNRRKTGELFWDRTSISPV
KDLAGQIIHFVAVKEDITEQKRNRELLDHQANYDSLTDLPNRSLALDRLRQATALSERSNDTVIVMLLDLDRFKNINDTLGHSYGDCLLQEIAKRLRYHL
PREITISRLGGDEFLIICPAVKEIHLEKLSQQLLKIISQPITIEAEELVITASIGVACYPNDGVTPEVLMRNADTAMYSAKRNGGNDFQLFMPTMNAEAH
ARIQLETHLRHALEQYQLKVFYQPIISLQDNHVVGLEALARWHDPELGNIPPDRFIPIAEETGLIIPLGYRVIEQACQDVAIWQQKYNYPFWVAVNLSPR
QLRSNRFTQITAKILQRHNFRPNYLKLEVTEQMLLDNTSTIAQMLDTLHRKGIALALDDFGTGYSALSYLRRYPFQSLKVDQSFLRDIPHSTESCALVKT
IVAMAHGLGMQAVAEGVETAEQVEFLKAIGCEYGQGYWFSRPLPAVEIDSFLAV------
>tr|C6HXD1|C6HXD1_9BACT Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Leptospirillum ferrodiazotrophum GN=UBAL3_92050053 PE=4
---------------------------------------------------------------------A-----LDE----RNTLIMALPDGVWLKDGN
GAWRIVNPGLALFGLSGRTDWIGKT---ERELARMNPPL----------------A------APDGAIHLIESRKIPLFNEDGSRKSLVVIGRDVTERIR
SEEVLRRYRHIFENAKEGILLMDESRKIVDVNPAFTATTGYTRDEAIGRNPNMLHSGRQDLRFYESMWASIDRDGFWEGEIWNRRKSGEAYCEWLGVTA-
IKKEERISGYIGIFSDITKRKEAEDRIVHMAFHDALTGLPNRRAFRERIGEVLERRSRE-LRFAVGILDLDGFKEVNDRMGHSAGDELLVLVSLRIKESL
RSTGTLSRLGGDEFGLLLVGPDL--EDVTFDRIVSALSEPFEIGGERVEISGSLGVTFSPPDRGDVDPLLSHADLALYRVKTREGNGWTPFQEEMEEALE
NRHRIKNELVRALSEKELVLHYQPQVDMVSGAVTGVEALVRWNHPKRGLLFPESFINVAEKSDLISSLGRSVMEEALAQQERWKTGGL-DLRVSVNIGAR
HFLSDNFLADLDAALSRHGICPVTLEIEVTETEALKDLSKAQKIIKRCLETGIVVSLDDFGTGQASLTSLQRLSVGEIKIDKGFVGKIQDSDKDRAIVSS
LVVVGRMMGIDVVAEGIETEADGLLLIGMGCRVAQGYAIAKPMPAEAVPAWIAD------
>tr|A0A024HG28|A0A024HG28_PSESB Uncharacterized protein OS=Pseudomonas knackmussii B13 GN=PKB_2504 PE=4 SV=1
---------------------------------------------------------------------QRSETA-------MRMAQRLA--------NV
GNWEWDAA-------SDRQVWSEQT---F-RIFGL-PSD----------------QPPFSALQ-SGAQRWVSVRGYGRRGSDGKVRQLYGALQDINERKL
AELAL--AAMVFDSSHQGIIVVDPQMRISRVNPAFTRITGYTAEEVVGQRPNVLSSGLHDPAFYSELYASLARDGYWSGEVWNRRKSGETYPEMLSISVA
HDDQGQPLHYIGVFSDLTQIKSQADQLDRMAHFDPLTGLPNRRLLGDRLDQAIARSLRS-HSLAVCYLDIDDFKSINQQGGTALGDSLLVTVGDNLKHVL
RSEDTLARLGDDEFVVLLTEIESEDCSSSLDRMLAAINAPIATEAGEFRLSASIGVCIYPDDDVDAGLLLRHADQAMCLAKAAGKNRYHLFDPDSDRKAH
ARRKLLDRAHSGLEADEFVLHYQPKVDLDTGALVGVEALVRWADPDQGLLMPGMFLPALQGSPLDMRLGEWVIRTALAQADAWRREGR-PVAISVNVSAC
HLLDQHFPEWLGSSLARYELPPASLELEILESVAIDDMARAIQVLRQCRKLGVHFALDDFGTGYSSLTYLRQLPVDTLKIDQTFVRDMLHDGDDLGIVEG
VIRLAETFDREVVAEGVETLEHARQLRRMGCRFGQGYGIGRPMPAQELPIWLES------
>tr|F7RNC5|F7RNC5_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domain) with PAS/PAC sensor(S) OS=Shewanella sp. HN-41 GN=SOHN41_01869 PE=4 
---------------------------------------------------------------------RQSETS-------LKQAQQLS--------GI
GSWEWDTV-------TNTHTWSEQV---F-AIYGL-TPK----------------K-AFEQLTETSVSAWIMVRGQATLDEQGKVIKLHGTVQDITQSRM
LQQQIALLQRVIQGSEQGYWDWNVATGEVQVSQKFEAILGYSAGEIQLTVHNWTHF------VHEDDWADVKRSASIELEVRCKKKSGNFCWVLCGRVVE
VDGRGRPLMISGTQADITQLKNHEAELDRVANYDVLTGLPNRRLLLDRFNQAISRVNRN-SLCAVCFLDLDGFKVVNDQYGHDVGDQLLIAIVEHLSYIM
REQDTLARVGGDEFVALF-EIDSTEGTQVLERMLGAINQTIYIGDKPLRLTASIGVSLYPEDNVDPDILLRHADHAMYMAKAAGKNCFQMFDHDVERKVI
AKRQWLEELKAAFAKREFVLFYQPKVNLATGEVIGAEALIRWLHPQRGILLPSAFLPDIEGSELEIPLGEWVINTALAQLQAWHKEGR-NIKVSVNVSAR
QLLADHFYDFLKQTLTDHDVPASALELEILESAAIKDMALAIAILNECVSLGVHFSLDDFGTGYSSLTYLRKLPISTLKIDQSFVRDMLEDQDDLRIVEG
VVRLATVFNLAAIAEGVESIAHGIKLAELGCQMCQGYGIAHPMYADDFINWYEN------
>tr|E6XM11|E6XM11_SHEP2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella putrefaciens (strain 200) GN=Sput200_2073 PE=4 SV=1
---------------------------------------------------------------------RKSEAG-------LRQAQQLS--------GI
GSWEWDLV-------TNTHTWSEQV---F-EIYGL-SPK----------------K-AIEQAAYT-SPCWIKARGQATRDEQGRIIKLQGTVQDITQARL
LQQQIAQLQRVIQGSDQGYWDWNVTTGEVQISPRFEAILGYQTGEMQLKATNWAQF------VCREDQREVKKTPSIELEVRCKKKSGELCWVLCGGIVE
VDSKGRALMISGTQADITQLKNHEAELDKVANYDALTGLPNRRLLLDRFKQAISRVNRD-RLCAVCFLDLDGFKAVNDHYGHDVGDQLLVAIVDNLSKIM
REQDTLARVGGDEFVALF-DICSAECTQVLERMLCAIDQTVLIGDKNLRLSASIGVSLYPEDNVDPDILLRHADHAMYMAKAAGKNCFQMFDPDVDRKLL
AQRKWLEELKSAFAKREFVLFYQPKVNLATGEVIGAEALIRWLHPQRGLLSPSVFLPDIEGSELEIPLGEWVINTAIAQIQRWYRSGK-NINISVNVSAR
QLLADHFYDFLKQTLANFDVNTSSLELEILESAAIKDMTLAIGILQECASLGVHFSLDDFGTGYSSLTYLRQLPVSALKIDQSFVRDMLVDQDDLRIVEG
VIRLASVFNLAVIAEGVETIEHGRVLATLGCQMCQGYGIAVPMTASDFMDWYDN------
>tr|W0DQP7|W0DQP7_9GAMM Diguanylate cyclase OS=Thioalkalimicrobium aerophilum AL3 GN=THIAE_02365 PE=4 SV=1
----------------------------------------------------------------------------------FQGILDHSSVMIYAFDSD
GKCLLANQVANMYGLATPSDVIGQT---REQLMSLQDSN----------------RHFQ---VRDGKIFYFLTDKFPLFDSNNQVFAVGGITYDITEQTE
HEKQLTISNEIFKKGQDGIMICDPDGCILSVNKSFEHITGYTEQECWKKNPRFLASGRHSVEFYKTFWDNLLRFGHWRGEIWNKRKSGEIYPQELSISAI
KDTQGNLINYLGVFNDITAKKQAEDEILHLAFYDGLTGVANRLLLRERTEQLISEASRE-IAFSLMFIDLDHFKEVNDVHGHDMGDLLLKQVTQRINQLI
RPQDTLARLGGDEFAILFPRLNPN-SLDLGERLVTTLAEPYLIQDANLHISASIGIALFPDDAQDYNTLLKHADLAMYHAKQSGRNSVYVFKNELETQLT
RTVNIETELRYAIERNEFVLVFQPQYALEQNQFTGFEALIRWQHPEMGTVSPEVFIPVAERSDFIIDLTDWVLSQALTTLQTLSGEHP-NLTLSVNISAR
ELIRSDFVERIRQHLSKHTINACQLELEITERIAMEQPQKALMIFQSLRRLGVSLALDDFGTGYSSLSYLKRYPLNTLKIDKTFVDEIGIDEEDEAVCKA
IISLAKAIGYQTIAEGVENQQQAEFLRTHGCDFIQGYYYAKPLKSDALTALFAN------
>tr|A0LD38|A0LD38_MAGSM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Magnetococcus sp. (strain MC-1) GN=Mmc1_3395 PE=4 SV=1
---------------------------------------------------------------------EKAKQVQESALARFEALFNSAPEGFILID-V
SGMVLECNTTLEMLGCKREDLIRKP---FSAFVHIEDQP----------------KFYIEIRAELANHALLESHDKLEATVAQRTAALKTSNEQLKQQMI
EREQARLTAGVFENTSEAIIITDAANRVMEVNPAFVRITGYPADEVIGRDPGFMKSHRHTHEFYAEMWKKIWQTGQWQGEIWDRRHNGEIYPKWLTINAV
YDERGHLVNCIGIFSDISRLKATEERLEQLAFFDCLTKLPNRAHFQSRLDHALTAANRR-NKVGLIFIDLDHFKHINDSMGHNAGDQLLIEAAKRIQSCV
REEDTVARMGGDEFTIILADLTDAVMTNVALTILESFTHPIVLEDKKLFIGCSLGMAIYPDDSGNAALLIKHADTAMYRAKESGRNRYSFYTAEMNAQAQ
SRISLESELRYAIDHKAFELYYQPKVDAHSSEIVGFEALLRWIHPTEGVISPNQFIPIAEESGLIAAIGNQVVEMACQGLQRINRCTPKPLPVAINLSVR
QLRQDNLVNYFSQTLANYGIEAEQLELEVTESFLAKPIEKSAALLQALHQLGYKIAIDDFGTGYSSLSYLKNFPIHTLKIDRSFVMEVAHNQESRTIVQA
IISMAHALGYDLVAEGVETAAQVNVLQGLGCGIMQGFHYARPAPLHEILEILSL------
>tr|G2H7P5|G2H7P5_9DELT Sensory box protein OS=Desulfovibrio sp. A2 GN=DA2_1781 PE=4 SV=1
---------------------------------------------------------------------CQRTAELAESTARFRALFELAPDAVYV-RGK
DGRILDCN-------RTAERLSGHP---RETLLAMRTAD----------------ILPIEAR-EPLPPSLSPDHDQNQNGDQDGGMAALVVVHDISGRRA
AERQARLFERVFRNALEGICITDPEGVIVAVNPAFTTITGFPAADALGNTPRILKSHHHDDAFYEDMWRALVEEGRWEDEIWNRRKNGEVYPEWLSISAI
PGPTGRTEYYVAVFHDITELKAKESQIQHQANHDALTGLPNRALLRDRLGMAINGARRE-RKVAVLSVDLDNFKQVNDSLGHMVGDIYLQQAAEQMRQMV
RPQDTLARVGGDEFVVVLQDVQGRDAAQVAERLLARFTEPVRVQEHELFVGASVGIALFPDDGDDPDTLVRNADIAMSRAKEQGKRRYHLFTPAMNERAV
RRLSLEGDLHRALAAGHIIAHYQPRVDLNTGLITGMEALARWTRADGSQEHPAEFIPLAESTGLIVPLGEHMLRLACARTRALHDAGHENLHVAVNLSVH
QFRHANLVGMVADVL-REGLPPHLLELEITESTIVTDVDHTLRKLNLLAEMGIALSVDDFGTGYSSLYQLKNLPLTSLKIDRSFIRDIPDDPNDAAIAAT
IITMADRLGLRVVAEGVETPEQLNFLLLEGCHEVQGFLFSRPLPPEDFTALLAR------
>tr|L8D6I5|L8D6I5_9GAMM Putative Sensory box protein OS=Pseudoalteromonas luteoviolacea B = ATCC 29581 GN=PALB_7110 PE=4 SV=1
-------------------------------------------------------VLWVVRRNRIQQMLLKAHRETQDSEARLKLALEGSNSGVWDWRSQ
NSLIYQP-RLKSELGYSHEN-VTLD--EYLAKIHPQDKAIRLEWLEFVQTQKGYFNCTYRLRHQNGHWRWYKDFGKVMEWQEHSPLAVAGTYTNMTRERV
FEERARIFGAAFEQTRDWVFILDKRLRIRACNTALQQAFGMAEIPLSSSSLT-LGLNRRVRMQYLRTISRLIPGEHFSVEETVTLGNGERRQVLVKVSAV
AGDNTDMVSYVVVMTDITEQKRAEKELHQLANYDAITGLPNRTLIIDRIHHAVEIVAKKEQPVAVLTINVKRLQNVAELYGVDVFSELLRSLAREFQSSL
KEYDSLAIGSQKEFYVVMEHVSGERVTNYCRDLIERFEHSFCLEGHSLQLSISIGVAVYPDDALDAVKLLQLSNLALHHAMQRNDSSYQFFKQEMNYRMQ
RASAIEKALYLALEQGAFTNHYQPIVDAKSHRVVGLEVLIRWPE--EVEFGAEELARIAEQNGLITKLTLQTLERALIDLATWQTAHP-NLYVSVNLSAH
DFKVPNIATQINAILQAQNVVGRYVAFEITESVLLADIPNAINQMHALKQLGCRLYMDDFGTGYSSLTYLQTLPVDALKIDKSFIEELETSASHHAIVKS
ILGLATNLGKVCIAEGVETQAQADLLTELGCSYLQGYWFSQPVSREDVLAQL--------
>tr|A0A0C1PN72|A0A0C1PN72_9GAMM Diguanylate phosphodiesterase OS=Pseudoalteromonas elyakovii GN=QT15_09910 PE=4 SV=1
-------------------------------------------------------SLWSYRKYRVEQLILAAHKETQDREARLKMALEGSNSGVWEWHAG
STLIYQP-RLVTELDYELES-VGLD--DYLQKIHPSDRAMRLQWLEFVTTNKGFIDCTYRLKDSKGQWRWYKDFGKVLEWDEGNPTQVAGTYTNLTRERL
FEERAALFGAAFEQTRDWVMILDKRLRIQACNRAMQNAFNLDSIPSSSTAVK-LGMSRQKRMMYLRQTLALAVHQHLSSEEVVSLPNGDERDVLIKISAV
ANGDGELYSYVVVLTDISQQKRTEKELYQLANYDLQTKLPNKALLMDRVQHAIKQSQAQETHFALLVIKFNRLQNLYDIYGADFVAELLPLLATKLRCCF
RELDSLATGHDKSFYVLMEHLDNEKVHQYVECLVHSFSTPLEAAGHTVQMQPTIGIAMYPDDASDAFELNQAAKAALEHVNVQQVSSYQFFREEMNGKVR
RSREVEQALMRALKNGEFSNHYQPIVDVQSDTLLGFEALLRWPE--NSEFCAQEYALAAEHAGVVTELTLQTLSRALVELRHWQTIER-DLYISINLSAI
DFESSSLVDNIQQALSRSKVSGHSVAFEITETALLSNVDSAVKVMKEIKALGCRIYMDDFGTGYASLTYLQQLPIDVIKIDKSFVQQIAEDPESYLIIRS
CVNLAHGLGLKCVAEGVENDLQYQRIKAEQVDYYQGYRFSLAISGEQVAQLL--------
>tr|U1KQ89|U1KQ89_9GAMM Sensory box protein OS=Pseudoalteromonas citrea NCIMB 1889 GN=PCIT_12754 PE=4 SV=1
-------------------------------------------------------GLWLYRKSRIEQMIIAAHKDTQNSEARLKLALESSGSGVWDWHLQ
SQLIYQP-RLFSELEYAQNN-IGLD--DYLQLIHPHDRGIRLEWLEFVSTNKGVFNCTYRLKHAKGHWRWYKDFGKVMAWQDGTPERVTGTYTNLTRERM
FEERARLFGAAFEKTRDWVFILDKNLRIQACNTALQQAFNIEAEPKSSTNLH-LGLNRHTRMSYLRKMTQLKVGQHISTEEQLVLANNQTCHVLIKISAV
DGLQGDLHNYVVVLTDISSQKRTEKELYQLANYDALTQLPNKALFIDRTHHAIEQNH-NTQPVAVLAIRFKRIQYYKDSYDKAYFESLLQQLATTLQCCF
RDQDSLAIGVNKEFYVLMEQVDDSQVVRYVSCLMRRFEAPISVLEQSCIMQLSIGVAMYPEDAMDAFTLNDNAKVALSHAAKHVGNHYQFYRTELNQQVQ
KTIEIEKRLQVACQRSEFSNLYQPIISGTSKVVDGFEVMLQWPT--NINYSQSELSDAAQQSGLVTELMLDTLERALIELKQWHLVSP-QLYISINLSPY
DFQYPELVSKIDSTLKRAQVQGKYVVFEVSEPVMMTDIPNALARMYQLRVLGCRLFMDDFGTSYASLTYLKQFPVDVLKIDKGFIQDIGIDTEHEIIIHS
ILSLAHNLGIQCVADGIEEAAQMKFLRLLGCDYFQGSLFSEPVLGEQVEDLL--------
>tr|U1K806|U1K806_9GAMM Sensory box protein OS=Pseudoalteromonas rubra ATCC 29570 GN=PRUB_21333 PE=4 SV=1
-------------------------------------------------------AFWVHRKNKVAGMILAAHRETQNSETRLKMALEGSNSGVWDWQSG
SQFVYQP-RLVSDLGYSNES-LVLD--EYLELIHPQDRALRIEWLEFVSTEKGFIDCTYRLRHINGQWRWYKDYGKVMAWQDGVPVQVAGTYTNLTRERV
FEERATLFGAAFEQTRDWVMIFDKHLRILACNKALQSAFSVSAAPSSSTSVT-LGLERDVRMKYLRAISKLKVDDLYVAEETLRLPSGEKRQVLLKISAT
ED-----KHYILVLTDITKQKRTEKELYQLANYDALTKLPNKVLFMDRVQHAIEQAHLSRQPLAIIAIKFSRLQRFADTYGNDFLALVTQKLATNLQCCF
REVDSLAIGNERDFYILMEQLAGEQVMRYIHCLLERFEKGFEIEQQQVHVKAKLGIAMFPDDASDAFDLNQAAETALNHARQSLVTDYQFYHSEINEQVQ
RALAIEQALLKAYQEEAFRNHYQPIINATHMSVEGFEVLLRWPQ--TPSYSIEELAHTAEQTGIITRVMLQTLERALVDLKEWHTTHP-DLYISVNLSAL
DFQYEELLARITDILARNGIDGRYLVFEITESVMMADAEQAIVRMHELRALGCRLYMDDFGTGYSSLTYLKQYPVDALKIDRSFVSDIGCDKEHEVIIHS
TLSLAHSLGKYCVAEGVEQMEQLSFLRMLGCERFQGYLFSKALPASEAGALL--------
>tr|F3BP68|F3BP68_PSEHA Putative sensory box protein OS=Pseudoalteromonas haloplanktis ANT/505 GN=PH505_cw00140 PE=4 SV=1
-------------------------------------------------------AMWVMRRNKIQRILLAANKESKESEARLKLALEGSESGVWDWESS
NPSIYQP-RLASELGYENET-VSLD--EYLSKIHPQDKQLRLEWLEFLSTDKGYFNCTYRLRHAKGYWRWYKDFGKVVEWDDKTPQKVAGTYTNMTREMV
FEEHALLFTAAFEQTRDWVFILDKNLNIRASNKSLQTAFNFSAESLSSRTLN-LGISRSNRFDYLRIMQKLSVGEHFSCEDSVVLANGESRHVLVKISAV
ADNEQRLNSYVIILTDINAQKSAENELHLLANYDALTGLPNRTLFNDRVEHALEQAKLHGCKVALLHINIKRFKYFNDSLGHEAADELIKEVAERLKCSL
RPSDSVARFGGDEFVVLVEDIHQEQVLIICTKLMDCVNQNIAINGQVVNVNLSIGVSISPDDAEQGPALLKAASIALYHAKDSLEGRYQFYKQEMNQHVQ
RALHLESQLTRAYREEEFCNYYQPIINAKSQKTEGFEVLLRWPE--NKLVQTQEFSLAAEGIGLITKIMLQTFARALLELKEWRKASP-NLYLSINLSAL
DFEFKELVPEIKKALNNSGVSSEAIVFEITESILMRDSKEALHSMEQLKKLGCRLYMDDFGTGYASLTYLKRFPIDVLKIDRSFVQDIGIDSDDEAIIQS
TLALADSLGKECVAEGVESSHQLAFLKARGCKHFQGYLFSKPVPNTEVLALI--------
>tr|Z5XTI0|Z5XTI0_9GAMM Diguanylate phosphodiesterase OS=Pseudoalteromonas lipolytica SCSIO 04301 GN=AT00_00375 PE=4 SV=1
-------------------------------------------------------AAWLFRRNRMQQILLAAHKESKESEARLKLALEGSHSGVWDWSSQ
SPIIYQP-RLKNELGYDSDS-VNLD--DYLAKIHPHDKQTRLEWLEFLSTQKGYFNCTYRLRHADGQWRWYKDFGKVVEWQDNTPEKVAGTYTNMTRELV
FEENARLFGAAFEQTRDWVFIMDKNLRIRATNQSFQSAFGFPADPRSSRSLT-LGLSIPARIHYLRVMQKLQSGEHFSAEDVVEVANGEKRQVLIKISAV
AGSNRQLDSYVIIVTDISAQKLAENELHLLANYDTLTGLPNKTLFSDRVSHAIEQADYHQTKAALLNVNIKRFKYFNDSLGHEESDELIKRVAKRLKQVL
RPQDSLARFEGDEFVILAEDLKQDELLSLCAKVMDCVESHIELNQQAVKVNLSVGVAVYPDDALDTKALLKAANVALYHAKRSVEGRYQFYKQEMNLQVQ
RTLHLESQLSKAYQEHEFCNYYQPIVSSKTRQVVGLEVLLRWPS--NDDYQPEDFANAAESSGLITKIMLQTLSRALIELRQWRVSHP-DLYISINLSAF
DFESTHLVENIHQALTLSHVPASAVVFEITESVMMRDSEKAQLSMNKLKALGCKIYMDDFGTGYASLTYLKRFPVDVLKIDKSFVHDIGVDKDDEAIINS
TLTLAKSLGKECVAEGVENTTQLRFLHARGCEYLQGYLFSKAVPGDEVSPLL--------
>tr|A0A063KX37|A0A063KX37_9GAMM Diguanylate phosphodiesterase OS=Pseudoalteromonas citrea GN=DC53_00935 PE=4 SV=1
-------------------------------------------------------TMWVMRRNKIQRILLAANKESKESEARLKIALEGSESGVWDWQSS
NPSIYQP-RLKNELGYDNET-VSLD--DYLAKIHPQDKQLRLEWLEFLSTDKGYFNCTYRLRHAKGYWRWYKDFGKVVEWDEKNPQKVAGTYTNMTREMV
FEEHALLFTAAFEQTRDWVLILDKNFNIRASNKSLQTAFNFSAESLSSRSLN-LGISRSNRFGYLRIIQKLLVGEHFTCEDTVVLANGESHYVLVKISAV
ADNEQRLNSYVVILTDISAQKSAENELHLLANYDVLTGLPNRTLFNDRVGHALEQAKKHSCKVALLYINIKRFKYFNDSLGHEAGDELIKKVAERLKCAL
RPSDSVARFSGDEFVALVEDVHKEEVLLICVKLMDCVNQNISVSGQVVNINLSIGVAISPDDAKESATLLKAANIALYHAKDSLESSYQFYKQEMNQHVQ
KTLHLESQLTKAYQEHEFCNYYQPIVNAKTYITEGFEVLLRWPE--NNLIQTQEFSLAAEGIGLITKIMLQTLARALEDLKEWRKVSP-KLYLSINLSAL
DFEFIELVPEIRKALSNANIPSDAIVFEITESILMRDSKQALHSMEMLKSLGCKLYMDDFGTGYASLTYLKRFPIDVLKIDKSFVQDIGIDSDDEAIIQS
ILALAHSLGKECVAEGVESSHQLAFLKERGCRHFQGYLFSKPVPNNEVLPLI--------
>tr|N6W0T7|N6W0T7_9GAMM Sensory box protein OS=Pseudoalteromonas agarivorans S816 GN=J139_05717 PE=4 SV=1
-------------------------------------------------------AFWVMRRNKIQRILLAANKESKESEARLKLALEGSESGMWDWQST
SSSIYQP-RLCNELGYDQES-VSLD--DYLAKIHPQDKALRLEWLEFLSTDKGYFNCTYRLRHAKGYWRWYKDFGKVVEWSGQLPKKVAGTYTNMTREMV
FEEHARLFTAAFEQTRDWVFILDKNFTVRASNKSLQTAFNFPSEPRSSRALN-LGISRSNRFDYLRIMQKLNVGEHFSCEDLVTLASGEQRHVLVKISAV
ADTEHRLSSYVIILTDIHAQKLAENELHILANYDSLTGLPNRMLFNDRVEHAIEQAQNHQCKVAMLHINIKRFKYFNDSFGREAADELIKQVAKRIKRSL
RPSASVARFGGDEFVVLVEDVQQEEVLLICSKLIDSVSQNMEFNGQVVNVNLSIGVAIAPDDAADHAALLKAASIALYHAKESLESSYKFYKQEMNQHVQ
KALHLESLLTKAYQEQEFCNYYQPIVNAHTQKTEGFEVLLRWPE--NTLVPTQEFSLAAESIGLITKIMLQTFARALQALKQWREISP-QLYLSINLSAL
DFEYEELVTDIHKALSHANVPSEAIVFEITESILMRDSKHALHSMEMLKKLGCKLYMDDFGTGYASLTYLKRFPIDVLKIDRSFVQDIGVDSDDEAIIQS
TLTLAHSLGKECVAEGIENKQQLQFLKQLGCKHFQGYLFSKPVPKEAVPALI--------
>tr|U1LEM3|U1LEM3_9GAMM Sensory box protein OS=Pseudoalteromonas undina NCIMB 2128 GN=PUND_10539 PE=4 SV=1
-------------------------------------------------------TAWVMRRNKIQRILLAAHKESQDSEARLKLALEGSESGVWDWQAN
QLNIYQP-RLVNELGYEDDS-VSLD--DYLDKVHPQERAIRLEWLEFLSTDKGYFNCTYRLRHAKGHWRWYKDFGKVVEWDETTPQKVAGTYTNMTREMV
FEEHARLFTAAFEQTRDWVFILDKNFNIRASNKSLQTAFAVSAEPRSTRSLN-LGLTRSSYFDYLRIMQKLEVGEHFSCEDTVVLANKEQRHVLVKISAV
ADESKRLSSYVVILTDIHAQKSAENELHLLTNYDSLTGLPNRTLFNDRAVHAIDQARRHNSKVALLHVNIKRFKYFNDSFGTENADEIIKLVANRLKTAL
RPCDSIARLGGDEFVILVEDIQQEEVLLICTKLMDCVNIDIAMNSQNVNVHLSIGVALFPDDAAHYKALLKASNVALYYAKDGLEGCYKFYKQEMNQRVE
RALHLESQLIKAYHEHEFCNYYQPIISTSTQKTEGFEVLLRWPE--NQLASTQEFANVAENIGLITKIMLQTFKRALVQLVRWRKVNP-DLYLSINLSAL
DFEFAELIPEIRQALNNAALPPEAIVFEITESILMRDSDYALKNMDALKQLGCKLYMDDFGTGYASLTYLKRFPIDVLKIDRSFVQDIGIDSDNEAIIQS
TLTLASSLGKECIAEGVESAHQLAFLKAQGCSYFQGYLFSKAVPKEQVLELI--------
>tr|G7EJG5|G7EJG5_9GAMM Putative uncharacterized protein OS=Pseudoalteromonas sp. BSi20652 GN=P20652_2947 PE=4 SV=1
-------------------------------------------------------AMWVMRRNKIQRILLAANKESKESEARLKLALEGSESGVWDWESS
NPSIYQP-RLASELGYENET-VSLD--EYLSKIHPQDKQLRLEWLEVLSTDKGYFNCTYRLRHAKGYWRWYKDFGKVVEWDDKTPQKVAGTYTNMTREMV
FEEHALLFTAAFEQTRDWVFILDKNLNVRASNKSLQTAFNFSAESLSSRSLN-LGISRSSLFDYLRIMKKLSVEEHFSCEDIVILANGESRHVLVKISAV
ADNNQCLNSYVIILTDISAQKAAENELHLLANYDVLTGLPNRTLFNDRVEHALEQAKHHQCKVALLHINIKRFKYFNDSLGHEAADELIIKVAKRLKLTL
RPSDSVARFGGDEFVVLVEDIHQEEVLLICAKLMDCVNQNISINEQVVNINLSIGVAISPDDALQGDSLLKAANIALYHAKDSLEGSYQFYKQEMNQHVQ
KALHLESQLTKAYQEHEFCNYYQPIINAQTYKTEGFEVLLRWPE--NKLVETQEFSLAAEGIGLITKIMLQTLARALGELKNWRKASP-ELYLSINLSAL
DFEFEELVPEIKRALNSADIPSEAIVFEITESILIRDSKHALKSMKMLKKLGCRLYMDDFGTGYASLTYLKRFPIDVIKIDRSFVQDIGVDSDDEAIIRS
TLALAHSLGKECVAEGVENLYQLTFLKALGCMHFQGYLFSRPVSREEVLPLI--------
>tr|Q3IFC9|Q3IFC9_PSEHT Pseudoalteromonas haloplanktis str. TAC125 chromosome I, complete sequence OS=Pseudoalteromonas haloplanktis (strain TAC 125) G
-------------------------------------------------------VAWVMRRNKIQRILLAAHKESKESEARLKLALEGSESGVWDWQSS
SLSIYQP-RLINELGYSVEC-VNLD--DYLVKIHPQDRPLRLEWLEFLSTDKGSFNCTYRLRHAKGHWRWYKDFGKVVEWHNKLPQKVAGTYTNMTREMV
FEEHARLFAAAFEQTRDWVFILDKNFNIRASNKSLQTAFNFPAEPRSSRVLN-LGISRSSRFDYLRIMQKLNVGEHFSCEDTVTLVNNEQRHVLVKISAV
ADNEHRLTSYVVILTDINAQKLAENELHILANYDQLTSLPNRALFNDRVIHAIEQAQRHNSKVALLHINIKRFKHFNDSLGREVADELIKTVAERLKSTL
RPSDSVARFGGDEFVVLVEDIQQEEVLLVCTKLMGCVNKNIALNGQVININLSIGVATYPDDAQQYKDLLKAANIALYHAKDNLEGSYKFYKQEMNQRVQ
KALHLESQLTKAYQEHEFCNYYQPIISANSQKTEGFEVLLRWPK--NQLVNTQEFSLAAESIGLITKIMLQTLGRALEELVAWRKIAP-ELYLSINLSAL
DFEFEHLVPEIKKALIKAAIPSKAIVFEITESILMRDSKQALSSMDMLKQLGCRLYMDDFGTGYASLTYLKRFPIDVLKIDRSFVQDIGVDSNDEAIIQS
TLTLAHSLNKECVAEGIESTHQLVFLKALGCDYFQGYLFSKPVPTNAVIPLI--------
>tr|U1K4F4|U1K4F4_9GAMM Sensory box protein OS=Pseudoalteromonas marina mano4 GN=PMAN_04552 PE=4 SV=1
-------------------------------------------------------AMWVRRRNKIQRILLAAHKESKDSESRLKLALEGSESGVWDWQSS
NPSIYQP-RLSNELGYKHDT-VSLD--EYLAKIHPQEKQLRLEWLEFLSTDKGYFNCTYRVRHAKGYWRWYKDFGKVVEWDEKTPQKVAGTYTNMTREMV
FEEHARLFTAAFEQTRDWVFILDKNFNVRASNKSLQTAFNFAAEPISSRALN-LGMSPKSRVDYLRIMKKLSEGEHFSCEDMVRLHNGESRHVLVKISAV
ADTEQRLSSYVIILTDIHAQKLAESELHQLANFDVLTGLPNRTLFNDRVEHALEQAQKHLCKAALLHINIKRFKYFNDSLGHEVADELIKKVAERLKCSL
RSSDSIARFGGDEFVVLVEDIHQEEVLLICTKLMDCVNQNISINDQVVNINLSIGVAISPDDATQSAALLKAANIALYHAKGALESNYQFYKQEMNQHVQ
KALHLESQLTKAYQEHEFCNYYQPIINAHTHQTEGFEVLLRWPE--NKRIQTQEFSLAAEGVGLITKIMLQTFGRALNELNEWRKASP-DLYLSINLSAL
DFEFIELVPEIKKALINANVPSEAIVFEITESILMRDSNLALQSMKKLKELGCKLYMDDFGTGYASLTYLKRFPIDVLKIDRSFVQDIGIDSDDEAIIES
TLTLAHSLGKECVAEGVESQQQLLFLTALGCKHFQGYLFSKPVPKEDVPALI--------
>tr|V4JG91|V4JG91_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain protein OS=Pseudoalteromonas luteoviolacea 2ta16 GN=PL2TA16_02516 PE=4 SV=1
-------------------------------------------------------ALWVHRKNRVAQLLMEAHKETRNSETRLKMALEGSNSGVWDWQSG
SNLVYQP-RLVNELGYKNDY-INLD--DYLELIHPQDRALRIEWLEFVSTAKGYIDCTYRLRNRVGQWRWYKDYGKVMAWREAVPMRVAGTYTNLTRERV
FEERAALFGEAFEQTRDWVMIFDKRFRILACNKALQDAFSVEANPLSSTSVS-LGLERHVRMHYLRTMSKLSEEEYHSAEEVLRLPSGEVRHVLVKITAT
LG-----QNYIIVLTDISKQKRTEKELYQLANYDALTKLPNKVLFMDRVQHGIEQIGGADHSLAILAIKFGRLQRLADTFGEDFVLAIIQQAATTLQCCF
REVDSLAIGQEKDFYILMEHLDSDAVTQYVHCLMARFEEGIRVHEQEVDIDVFVGIALFPNDASDAFELNQAAEIALSHAKKSPISYFQYYHQDINQQAK
RHIEIERRLNAIHKDELLCNYYQPILNATRGHIEGFEVLLHWPD--DSSVSAQEFSTAAEKTGLGIDLILQTIERALIELKVWHLTWP-DLYISVNLSAQ
ALHYDGLVQQVQHALEKTNLPASCLVFEISESVMMENVADSIERMHLLKTLGCRLYMDDFGTGYSSLMYLTQFPVSTLKIDGGFIVDIGKNKDHESIIHS
TLSLAHSLGKYCVAQDVENIEQLRFLRMLGCERFQGFLFSPPLPGDMIAHLM--------
>tr|A0A0C1MEP3|A0A0C1MEP3_9GAMM Diguanylate phosphodiesterase OS=Pseudoalteromonas luteoviolacea GN=JF50_22920 PE=4 SV=1
-------------------------------------------------------ALWVHRKNKVAQLLMEAHKETRNSETRLKMALEGSNSGVWDWQSG
SNLVYQP-RLVNELGYKNEY-INLD--DYLELIHPQDRALRIEWLEFVSTAKGYIDCTYRLRNRVGQWRWYKDYGKVMAWREAIPMRVAGTYTNLTRERV
FEERAALFGEAFEQTRDWVMIFDRRFRILACNKALQDAFAVEANPLSSTSVS-LGLERHVRMHYLRTMSKLAEGEYHSAEEVLRLPSGEVRHVLVKVTAT
HG-----QNYIIVLTDISKQKRTEKELYQLANYDALTKLPNKVLFMDRVQHGIEQCEENEQSLAILAIKFGRLQRLADTFGDDFVLAVIRQGAKTLQCCF
REVDSLAIGQERDFYILMEHLENDAVTRYIHCLIARFEDGMRVHEQDVHVDVHVGISLYPDDASDAFELNQAAQIALSHAKKSTKSHYQFYHHDINQQVK
RNIEIERRLTAVYNEELLYNYYQPILNATREHIEGFEVILKWPD--DPLVSADEFAKAAEKTGLGIEVVLQTIERALIELKVWHLTWP-DLYISVNLSAH
VLHFEGLVEGIQSTLKKTNLPASCLVFEISESVIMHNVTQSIARMHALNSLGCRVFMDDFGTGYSSLMYLTQFPVTTLKIDEGFIVDIGKNKDHESIIHS
TLSLAHSLGKLCIAQGVENIEQLRFLRMLGCERFQGYLFSPPLPGDMIAHLM--------
>tr|A4C9D0|A4C9D0_9GAMM Putative Sensory box protein OS=Pseudoalteromonas tunicata D2 GN=PTD2_09124 PE=4 SV=1
-------------------------------------------------------FIWFHRRSKMQQKLVVAHKESQESEARLKLALEGSGSGVWDWNIE
STTIYQP-RLVNELGYSQDH-VTLD--EYLNKIHLEDRAKRIEWLEFLSTNKGSFKCIYRVRHKSGYWRWYKDFGKVMVWDNQMPSKVAGTYTNMTNEFE
SEENARLFGAAFEYTRDWVFILDKQFRVRATNQVLRESFNFNASHTSSRKLS-LGLNKDTRLNYLRIIAKLKAGEHFQSDEVVVTADGIAHPVIIKVSTV
GDKDNNINNYIVVITDISEQKDAEKELRVLANYDTLTKLPNRSLLLDRISHATELSRRHKNRLALLFIDLDHFKQVNDTLGHDLGDTLLITVAQRLKYGL
RKQDTVARLGGDEFVILIEDIDTDELIPVCRKICEEVSLPVQLGNHRMTVEPSIGVAIFPDDADNSLDLLKSADIAMYHAKKRGGATYQFFHQEMNHKIQ
RKVQLENELKEAVKLNQFVNYYQPIISATDFTLKGFEVLLRWRQD-NKLISPAEFIPVAESMGLITTLTFAALTRAMQDLKAWLVSKP-DCYVSVNLSAR
DFEHETIGEKLTDIILQADISPTQVVFEITESALMQDSQKALEAMLILKQKGCRIYMDDFGTGYSSLSYLKRFPIDVLKIDQSFVADIGQDASDEAIIHS
TLALAHSLGKSCVAEGVETKAQVEFLQMLGCDYLQGYLFSKPVPSNEVSNLL--------
>tr|U1M9V6|U1M9V6_9GAMM Sensory box protein OS=Pseudoalteromonas spongiae UST010723-006 GN=PSPO_02530 PE=4 SV=1
-------------------------------------------------------SVWMLRRHRYQTRLLAAHKQSSENATRLKMALQSSQSGVWEWQSG
LGHSYQP-RLVDELGFDKSE-VSLD--EYLAKIHPDDRARRIEWLEFVSTDKGEFELAYRVRHSQGHWRWYKDVGRVIEWDEDVPQRVSGTYTNFTRERD
FENSARLFSAAFEHTRDWVFVMDREFNILAINKALRESHHFDLKHDSARKLS-LGLSAKRRTYYLRALGKLNVGEHYQSEETITSPNGTKYNCLIKATAI
AAENGEVDNYIVVITDISSQKEAEQALYLLANYDKLTKLPNRSLFIDRVAHAISLNKNSEQLLTVLFIDLDQFKKVNDSFGHHDGDKLLVEIAERIKQVI
DGKATAARLNSDEFTVLLENINSEDVVALCQRLIAALKEPFALAGETVRITASIGVAIFPDDETTAINLIKAADIAMYHAKKRGGECFLFFQQEMNKKVQ
RLLRLESRLKQAHSENELSNQYQPIIDVNTGKVVGFETLMRWQHN-GEAISPSRFIAIAENTGLITEMTMASLTRAVQDMQRWCEIDN-DFYVSINLSAK
DFHHLDLAEQIIALCNTYEVPCHMVALEITESVLMADFDSAKAAMDKLKSAGCRIYLDDFGTGYSSLAYLKRFPVDVIKIDGGFVRNIGDEADDEAIIRS
TLALAKSLGKVCIAEGVESKEQLLFLQAEGCEYVQGYYFYSPLDASQVKSLL--------
>tr|I1E290|I1E290_9GAMM Cyclic di-GMP phosphodiesterase Gmr OS=Rheinheimera nanhaiensis E407-8 GN=gmr PE=4 SV=1
-------------------------------------------------------YKLYRFRRRQHAEIQQAHQKVQLSEQRLKQALQSVNSGAWEWSAN
TNQLYAA-RIHTMLGYPENINLTMQ--QHMTLIHPDDRTSASQWQRFLHDTSSGFDCTYRMQHQQGQWLWFRDQGKATDIEDGKLQKVVGTFSNITETRA
NQEKARLFGEAFQQTRDWVVILDHRQRVLAANQSFAAAFGNMEHYLEQPRTHH-GISLVRRRFYTKLLKELQPGQHWQGEEQVITPDGRERPTLINISAI
G---QQQTFFVLVFTDITAQKQAEDELRYLANYDALTGLPNRALLMDRIYHGIDQAKRDKRSLALCFIDLDKFKQINDSLGHDIGDLLLKEVARRLTLTL
RESDTVARLGGDEFVVLLEGYKADNISHVARKMLSVVSEPMLLATHTVGVSPSIGIAVYPEDALSAGELLKHADVAMYHAKEAGRNNFQFFTAEMNEKAH
MRLARETRLRKALHNDEFVNFYQPIVNSQTRQVVGAEVLLRWQSS-EGIVSPAEFIALAEELRLIINMTHDLLERALTDLAKWHDDGH-LLYLSVNLSTR
HLEQPALADYVRGLLQKYNLSASYLRFEVTESALMRDHQSAIETMLALSELGVQLALDDFGTGYSSLKYLKELPIDGIKIDRSFVQDIGIDSSDETIIEA
MLSMANSLGMYCVAEGVETEQQLAFFNRRHCYLIQGYLFAKPMPADAMPAFL--------
>tr|J1QI81|J1QI81_9ALTE Cyclic di-GMP phosphodiesterase Gmr OS=Alishewanella aestuarii B11 GN=AEST_19030 PE=4 SV=1
-------------------------------------------------------LLVWQRRRQQQLLLRRAHKELLSSEQRLNQALSSINSGAFEWQAS
NNNLESN-RLPRMLGTSELMNITWQ--QHCSLIHPDDLANEQQWQRVLAQPELMLDITYRMRHQDGRWLWFRDRGRVIELSALQPSRVTGTYSNITETKA
NEEKARLFGEAFQQTRDWVVILDTRQRVLAANQSFCQAFGGIEPYLDSPRVHH-GISLVRRRYYTQLLKTMAKGDHWQGEEQVITPDGRERPTLINISAV
G---D-VSFFVLVFTDITAQKAAEDELRYLANYDALTGLPNRALLMDRILHAIEQAKRERRSLALCFLDLDKFKHINDSLGHDIGDLMLKEVARRLKLTL
RDSDTVARLGGDEFVVLLEGYKSDNISHVARKMLHTISEPMQLGSETVAVSPSIGIAIYPDDALNGTELMKHADVAMYHAKEAGRNNFQFFIREMNEKAH
MQLARETRLRRAIAQQEFVNFYQPIIDSREHSIVGAEVLLRWQSS-DGMISPAEFIPLAEDLRLIVNMTQQLLERALSDLQQWRQADY-ALYLSVNLTTQ
HLEQPALAETVLALLKKYRLPAHALRFEITESALMRDQQSAIRTMQSLSDAGIKLALDDFGTGYSSLKYLKELPLDAIKIDRSFVQDIGIDHNDETIIDA
MLSMAGSLGLYCVAEGVETEQQLAFFNKRHCYLIQGFLFSKPLPADALLALL--------
>tr|K6YF81|K6YF81_9ALTE Diguanylate cyclase/phosphodiesterase OS=Glaciecola polaris LMG 21857 GN=GPLA_0472 PE=4 SV=1
-------------------------------------------------------YVVWKRRRFQAQRLRSAHREALQSKARLSLALRASNSGVWEWDEW
TDQVLAS-RITGELGYRDKLEVPRE--EHIALIHNRDREHLSQWGAFIRSKDKVLDVTYRMITQQGHCLWYRDVGNVTGGANEGNQKVVGTYTNVTESIT
EQEDLRLFGEAYKHTRDWVLVCNRHTEPLAANQAFCDTFGIDDQNDIARQLRHRGNETELLQFWST-LKELKAGDDWRGEDQIILHNHEVRDVLVYIKAV
ASINTDIDSYLIILSDISEHKKAQQALMKLANFDSLTGLPNRTLLLDRVNHAIDQAQRGTHTLGLFFIDLDKFKQVNDSLGHSAGDTLLQEISARLLNLL
RKEDTIARLGGDEFVVLIEHVQSEGLTHLASQIINIIDTPVQLDNHMVSVSSSIGIALYPEDALNAEELLQNADIAMYHAKENGRSNFQFFTAKMNVLAQ
QRLALESDLKSAHSQQKFENHYQPIVDISRNEIVGFELLMRWFTD-TGKVSPGRFIPVAEELGLIESMTLQAMERALPMFKYWQEVNF-KGYLSINLSAR
HFESLQSINDIIAFLATNQLPVNAVRFEITESALMKDYQKAIVYMQRLKEVGFCIALDDFGTGYSSLKYLKEFPLSVIKVDKSFVDDIGINSNNEALIET
ILRMAQSLDMYCVAEGIETLEQVEFFKQHECHFLQGYYFSRPVAMGDTFALI--------
>tr|F7P0A0|F7P0A0_9GAMM Diguanylate cyclase (GGDEF) domain-containing protein OS=Rheinheimera sp. A13L GN=Rhein_3498 PE=4 SV=1
-------------------------------------------------------LFYLRTRQKQQRMLKVAHAKVTASEQRLKQALDSIDSGAWEWHAR
KNIMFAS-RIHSMLGYQEALNLAMS--QHLSLLHPEDKDAQQAWLKLMQTPDKTFDHTYRMQHKNGKWLWFRDIGKVAEVDEGQPERVIGTFSNITETRA
NQEKARLFGEAFQQTRDWVVILDASQRVIAANQSFADVFGSVDQYLVSPKTHH-GISLQRRRFYTSLLRGLTVNQHWQGEELVHTPDGKERPALINISAI
G---DKVEFFVLVFTDITAQKVAEEELRYLASYDSLTGLPNRTLLMDRIQHGIDQAKRAKKSLALCFIDLDKFKQVNDSLGHDVGDQLLQEVARRLRATL
RETDTIARLGGDEFVVLLESYKNDNISHVARKMLQSIGEPMQLGTHTVSVSPSIGIAVYPDDATDANSLLKHADVAMYHAKDLGRNNFQFFIAEMNEKAH
MQLAKETQLRQAFKDGEFINYYQPIVDCRSQSVIGVEVLMRWSHK-NTLIPPTEFIPMAEDLRLIIPMTLSLLERALVDLQQWRQAGL-DLYLSVNLSTS
HLEQLSLAEHTEKLLNKYQLPPSCLRYEVTESALMRDHEKAITTMLALNQLGIQLALDDFGTGYSSLKYLKELPIDAIKIDRSFVKDIGIDPDDETIIEA
ILSMAGSLGMSCVAEGVETEQQLAFFSSRQCYLIQGYLFAKPMPAIELINWL--------
>tr|I8U3M1|I8U3M1_9ALTE Sensory box protein OS=Alishewanella agri BL06 GN=AGRI_15420 PE=4 SV=1
-------------------------------------------------------AWFLRRRRQQHAVLQQAHQQVSISEQRLNQALSSVNSGAFEWLAS
SNTLESS-RLPRMLGTSELMQITYQ--QHCSLIHPDDIANELQWQKVLEQPGQMLDVTYRMRHQDGRWLWFRDRGRVTEFAEQQALKLLGTYSNITETKA
NEEKARLFGEAFQQTRDWVVILDTRQRVLAANQSFCQAFGGIEPYLDSPRVHH-GISLVRRRFYTQLLKTMVKGDHWQGEEQVITPDGRERPTLINVSAV
G---G-VSFYVLVFTDITAQKVAEDELRYLANYDALTGLPNRALLMDRILHGIEKAKREKRSLALCFIDLDKFKHINDSLGHDIGDLMLKEVARRLKLTL
RDSDTVARLGGDEFVVLLEGYKNDNISHVARKMLATISEPMQLGSDSVAVSPSIGIAIYPDDALNGTELMKHADVAMYHAKEAGRNNFQFFIKEMNEKAH
MQLARETRLRKAIQRQEFINYYQPIIDSREQSIVGVEVLLRWQSS-DGMISPAEFIPLAEELRLIVEMTQQLLERALYDMQQWRRAGM-NLYLSVNLTTQ
HLEQPALAESVLALLDKYQLPTVALRFEITESALMRDQQSAIRTMQALSDAGIKLALDDFGTGYSSLKYLKELPLDAIKIDRSFVQDIGIDHNDETIIDA
MLGMAGSLGMYCVAEGVETEQQLAFFNKRDCYLIQGFLFSKPLPAAELLALL--------
>tr|A0A099KYH1|A0A099KYH1_COLPS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Colwellia psychrerythraea GN=ND2E_1877 PE=4 SV=1
-------------------------------------------------------VIWYRYRKTQQQELLDIHEKVKYRENRLQLALTGSNSEVWDWQAD
ENLMFGK-RIALDLGYREKALYSLE--EHTALIHPEDYDNIHCWQLFINSAKDNFSCTYRLKTSDGQWFWYKDLGKIVAVTNNKPVRVTGSYTNITESRA
NEERAQYYGDAFQQTQDWVFIIDEKISRITANQSMRAVFDWPEEEDFSDK--LLGVSQKRRIFYRKLMLSLKEGEHWRGEELIVTANKDEYHVIINVTVG
L--STNALHYLFVLTDISAQKSAESELRLLANYDHLTGLPNRTLLLERIKHAIDFSNRRDTSIAVFFIDLDRFKQVNDSLGHEFGDLLLQEITKRLKSAL
RIDDTVARIGGDEFVVLLESFANNKLGRIAEKVIDTIGQSIDLDGNVVSVGASVGIALYPNDGINSDELLRHADVAMYHAKQAGKGNFKFYTAQMNVEAM
ERLNLESALKLAVKNDEFINHYQPIIDAYSGKAVGVEMLMRWQTP-TDLVPPNDFIAIAEELNLIIKMTEMALERVCKDLKEWHTIRP-DFYVSINLSVQ
HFVEADIVSFISKLLARYQLPAAILRFEITESSLILQPENAITTMRKLSSLGITLALDDFGTGFSSLSYLKKLPLDIIKIDRSFVSGIGINEADEAIVDT
TLVLAKRLNLHCIAEGVETAGQLNYLVAKQCHYIQGYLYSKPRPAKIIMENL--------
>tr|U1L0W9|U1L0W9_9GAMM Diguanylate cyclase/phosphodiesterase OS=Pseudoalteromonas marina mano4 GN=PMAN_08020 PE=4 SV=1
-------------------------------------------------------ALFFWQYRSRQNVIQQAHTDTINSKKQTELALKNNKSGIWDFRFE
DGSV-NT-LRGIELGYENLEEVSIE--LFYSIIHPDDKRRETKWQSFISKKNKNWQLTYRLRHKNGQWLWYQDTGQIIFDQTGKPLYVSGIYTNITEQRA
NEEQAKILGEAFSQINDWLLILDDHLMPFSANNSFIRTFSDS-E-FTNISPKLKSIGKENCKEFAKILKKLQPTENWHIDTLIKTAKSSKHPVHINVTAV
AKSTTEVSYYVIVISDLTEQKRAENELRYLANYDALTKLPNRSLMYQEIEEAIKQAESSNTHCALLFIDLDKFKPVNDSFGHAVGDKLLCNITERVNNIL
NENAQLGRQSGDEFLVLIKNVESDSLKETVMLISKELANKVMIEDFAINISASIGVALYPFDAITTDILIRNADVAMMQAKQNGRNGFSFFSDEMNEQIK
QKLMLENDLKDAVKADLFFNHYQPIVDIEARTINGVELLMRWKNK-EQFVSPAVFIPISEETGLIERLTELALKRALIELAPLLNDNP-LFYISLNLSPK
HILKENITERLQCILADAGILPKQLRLEITETILLEDKLKAAKQLQKLKAAGFKLLLDDFGTGYSSLTYLSQFPINVIKIDQSFVNSIGEDKGDESIIKT
IISLAENLNLYCIAEGVENRQQMEFLSNEGCHILQGYYFAKPMSAEALNENS--------
>tr|Z5XNL1|Z5XNL1_9GAMM Diguanylate phosphodiesterase OS=Pseudoalteromonas lipolytica SCSIO 04301 GN=AT00_13575 PE=4 SV=1
-------------------------------------------------------FFIFWQYQARQKAIRKAHDEVLKSQQQTELALSSNKSGVWEANLA
EQTFFNS-RCAVELGYSEFKDLPIA--DFIQLIHPLDRRLISQWESFSKQNNEQWNVTYRLKHKNGEWLWYQDVGRVVETDDNKPLKISGIYTNITEQRA
NAQQAAVLGEAFSQINDWLLILDSQLKPFSANTSFSEAFSTP-K-ITELTVKDGAIGKSHYLEYLNVLKTLKPKQNWKTEAYIRTLKSPAHPVHISVTAV
AKDSQSINYYVIVISDLTEQKRAEDELRYLANYDPLTGLPNRTLMHSKINSCINSSKKRNKLAALLFIDLDKFKPVNDSFGHAVGDQLLCNITQRVSLIL
PENAVIGRQSGDEFLVLVKDLHSQSLSELVKKLTEELASKVIIDDFSINISASIGVALYPFDAKTADDLIRNSDIAMMHAKQSGRNNFKYFTEQMNNQLT
KKLLLENALKDAFKDDELFNNYQPIVNAKTKEIHGAELLMRWRNE-QGFVSPAEFIPIAEEIGLIELLTEQALDRALTELLPLLRANP-HFYLSLNLSPM
HILKSNLTERLLMILSNHLIKPVQLRLEITESTLLEDKEKASKQLKMLKNAGFKLLLDDFGTGYSSLTYLSQFPIDVIKIDQSFVRNIGLDKSNESIIRT
IHALSSNLGLYCIAEGVETLDQINFLRNMGCNDLQGYYFAKPMLADELIAQQ--------
>tr|K6X700|K6X700_9ALTE Uncharacterized protein OS=Aliiglaciecola lipolytica E3 GN=GLIP_3763 PE=4 SV=1
-------------------------------------------------------LFWWYRRDLQNKQVMAAHAQALESKNRLSLALSASNSNVWEWRSK
TNQFYAP-RICEELGYDYEDNISFE--QHVDLIHPEDTAIASNWQSFKDKESDGLDVTYRLRSKLGEWFWYRDVGNEVVDKVGLERVVAGTYSNVTETVA
DREKVRLFGEAFKHTRDWVVIFNTQMVPVAVNTAFCEAFGINEDGDLKIQLTRKLDAEYPPRFWKK-LSELNVTGHWKGEEQLVIDQGKVSNVLINMTSI
ASMRGEIDYYLMIMSDISEQKEAENELRRLANFDGLTDLPNRTLLLDRIKHGIDHAARHKSKMGVFFIDLDRFKQVNDSLGHKAGDELLIVVAQRLTNLL
RQDDTVARLGGDEFVVMVEEVKHDRLSILAQQLIDILEAPIQLGNQTVSVSSSVGIAIYPGDASTPEELLRNADLAMYHAKEQGRSQFQYFTEHMNEKAQ
ERLLMENRLKKAHQSKVFINYYQPIVNITSGQVVGFELLMRWPEK-DSMVPPDQFIPVAEELGLIENMTWDALERAMPVLSEWQSKGR-EIYLSVNLSAR
HFERQISIDHIVLLLEQYGLPVSSLRFEITESALMRDYERALEYMDSMRQHGFVIALDDFGTGYSSLKYLKEFPIQVLKVDKSFVDDIGNNKSNEALVLT
TLRMAESLDMYCVAEGIEEKEQIDFFKRHGCHHLQGYYYSKPVPEEQTADLI--------
>tr|Q15V87|Q15V87_PSEA6 Diguanylate cyclase/phosphodiesterase OS=Pseudoalteromonas atlantica (strain T6c / ATCC BAA-1087) GN=Patl_1680 PE=4 SV=1
-------------------------------------------------------YIFWKMRSLQAQRLLSAHKEAVQSKGRLTLALQASNSDVWEWDEK
SDTVQAS-RFHDELGYENKTGVSRE--EHLSLIHNRDKEMLARWHSFLEQEDRVFDVTYRMRSHNGHWLWFRDVGNVTGGASEHNQRVVGTYTNITDSIA
EQEDLRLFGEAYKHTRDWVLVCNRHTVPMAANQAFCNTFNIDEQQDIASQLKLDDQQAGLLSFWSK-LESLEASEDWRGEDQIMLQNEEVRDVLVYIKAV
ACINTDIDSYLIILSDISEHKKAQQALIKLANFDALTGLPNRALLLDRVDHAIYQAQRSASTLGLFFIDLDKFKQVNDSLGHNAGDTLLQEISARLLNLL
RKEDTIARLGGDEFVVLIENVHTDDLTHLASQIIEIIDTPVQLENHLVSVSSSIGIALYPDDAQDAQELLQNADIAMYHAKENGRSHFQFFTAKMNVLAQ
QRLALESDLKYAHSHQQLENYYQPIIDISRNKIAGFELLMRWFTD-TGKVSPGRFIPVAEELGLIESMTLQAMERALPMFKHWQANGF-DGYLSVNLSAR
HFESLQSIKDVIAFLASNALPVEMVRFEITESALMKDYQKAIIYMKHLREAGFSIALDDFGTGYSSLKYLKEFPLSVIKVDKSFVDDIGINKNNEALIET
ILRMAQSLDMYCVAEGIETKEQVAFFKEHDCQFLQGFYFSRPVALADTFALI--------
>tr|L8D3B5|L8D3B5_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudoalteromonas luteoviolacea B = ATCC 
-------------------------------------------------------LLWLRQNTKKQTLIKSALHEMTNSQKETQLALRATNSGVWEVNLN
DKLVSQK-RLSVELGYGNLGDMPLE--KHASLIHPQDLDAVKQWNSVLSKQDAAFEVTYRMRAKSGEWVWYQDVGRISE-YEGTPITVSGIYSNITEQKA
TNTMASILGDAFGQINDWLLILDSNLMPIAANSSFCHAFDINEA-IKSLTFKQETLGSKNFSNLLKHIRALEPRQNHREEVLLRTTHNPKHPIQLSINAI
TKSTNHIDYYVIVLSDLTEQKKTEKEFRFLANYDSLTGLPNRSLMLKRIQKAINQAQ-NDQLVGLLFIDLDKFKPINDSYGHEVGDKLLGAISRRIEANL
FAGCTLGRQSGDEFLVLIESVSSSDISILVNTLLQALPEKITIDGFTVSISASIGAAIYPFDANNAEKLIRHADVAMIHAKQGGRNSFKFFTTAMNEEIL
RKLQLETALKTACKENQFFNHYQPIVNSRNNRVVGVELLMRWIDN-GQFISPAEFIPVAEEVGLIEIMTDQALKRALVELKPLLQQNG-DFYISLNLSAH
QVLRANIAEHLVTILYEYGVPCSRLRLEITESTLLADKVKAKTALLELHEEGFILLLDDFGTGYSSLTYLSHFPIDIIKIDQGFVRSMESSSNNKSIVKT
ITMLAQNLGMTCIAEGVESKEHIRYLSQLGINYMQGYYFSRPVPAEVLLADL--------
>tr|A0A099L4K4|A0A099L4K4_COLPS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Colwellia psychrerythraea GN=GAB14E_1674 PE=4 SV=1
-------------------------------------------------------VTWYRYRKKQQQLLLDAHEQVKYRENRLQLALTGSNSEVWDWQAE
DNLMFGK-RIAIDLGYVEEALYSFE--EHVSLIHPEDHDDIRCWQLFISNADDNFSCTYRLKTSGEKWLWYKDLGKIVAVAQNKPIRVTGSYTNITESRA
NEERAQYYGDAFQQTQDWVFIIDEKISRVTANQSMRAVFDWPEEEDFNAK--LLGINPKRRSFYHKLMLSLKEGEHWRGEELIITANQDEYHVIINVTVG
R--NSNAIHYLFVLTDISAQKSAENELRLLANYDHLTGLPNRTLLLERIKHAIDLSNRQTKSIALFFIDLDRFKQVNDSLGHDNGDLLLQEVAQRLEAVL
LIDDTVSRIGGDEFVILLESFSNNQLCRIADEAIEAISKPIDLGGNVVSVGASIGIAVYPNDGHNSDELLRHADVAMYHAKQAVENNFKFYTAQMNIEAM
ARLSKESALKLAVKNNEFINHYQPIIDAHTGKAVGVEMLMRWQTP-TGLVPPNDFIPLSEELNLIITMTESALERACKDLKDWHTIRP-EFYVSINLSVQ
HFVEADIVSYISELLVRYQLPAKILRVEVTENALILQPENAITTMRKLSALGLTLALDDFGTGFSSLSYLKKLPLDIIKIDRSFVSGIGINDADEAIVDT
TLVLAKRLNMHCIAEGVETTEQLHYLVAKKCHYIQGYLYSKPISANEIMQNL--------
>tr|G7F1L4|G7F1L4_9GAMM Sensory box/GGDEF family protein OS=Pseudoalteromonas sp. BSi20429 GN=P20429_1151 PE=4 SV=1
-------------------------------------------------------FFIFWQYRSRQVAIEQAHRATIHSQKQTELALKNNKSGVWDYNFK
DASV-ST-LRGSELGYTGLPVVHID--QFLALIHPDDRRRENQWENYFK-KQQNWQATYRLQHKNGHWLWYQDTGQVIYDQTNEPLYVSGIYTNITEQRA
NEQQAKILGEAFSQINDWLLILDKHLMPFSANNSFIETFSNE-Q-ATKISPKLRAIGKDKCREFANILKKLKATENWQSDAYIKTAKSNEHPVHISATAV
TKDT--ASYYVVVITDLTEQKRAENELRYLANFDPLTHLPNRSLMYQNIEKAIKHANESNTQCALLFIDLDKFKPVNDSFGHAVGDKLLCNITQRVNGML
GVNAKLGRQSGDEFLVLIQNIKSQSLRDTVRKISNELANKVIIEDFSINISASIGVALYPFDAVTTDILIRNADVAMMHAKQGGRNDFKFFSDEMNELIK
QKLLLENDLKDAVKDNRFFNHYQPIIDIQEKTINGVELLMRWKNQ-GQLVSPALFIPVAEETGLIELLTEQALQRALIEIAPILSANP-LFYISLNLSPK
HILKTNITQRLMSILADSQVHPRQLRLEITESILLEDKLKAAKQLQNLKAAGFKLLLDDFGTGYSSLTYLSQFPINVIKIDQSFVNSIGIDKGDESIIKT
ILSLAENLDLYCIAEGVETREQMIFLAEVGCTVLQGYYFARPMDAKDLRKSD--------
>tr|A0A063KKQ0|A0A063KKQ0_9GAMM Diguanylate phosphodiesterase OS=Pseudoalteromonas citrea GN=DC53_14155 PE=4 SV=1
-------------------------------------------------------SLLFWQYRSRQIVIGKAHRATIDSQKQTELALKNNKSGVWNYYFK
DNSV-NT-QRGKELGYLDLPKIQLD--DFLALIHPDDRRQEGQLLSYAQQLQNNWQATYRLRHKTGHWLWYQDLGQIVYKQSSEPLYISGIYTNITEQRA
NEQQAAILGQVFSQITDWLLILDDQLMPFSANNSFINTFSNK-K-IAELNPKLKAIGKAKCKEYSAILKALKPTQNWRTDAYINTAINNEHPIHISVTAV
AKDTNDVSYYVVVISDLTEQKNAENELRYLANFDPLTRLPNRSLMHQKIEKAINHADKSNKQCALLFIDLDKFKPVNDSFGHAVGDKLLCNITERVTNIL
SNKATLGRQSGDEFLVLIKHVDSKSLTETVKKISRELASKVIIEDFSINISASIGVALYPFDAINADLLIRNADVAMMHAKQAGRNGFKFFSEEMNEEIK
QKLILENDLKDAVKDNRFFNHYQPIVDIKTKTINGVELLMRWDNK-GQLVSPAVFIPIAEETGLIEKITEQAMKRAFIELAPILSNNP-LFYISLNLSPK
HILKANITDRLLYILAKSQISPRQIRLEITESILLEDKFKAAKQLQNLKAAGFKLLLDDFGTGYSSLTYLSQFPIDVIKIDQSFVNSIGFDKDDESIIKT
IYSLAENLELYCIAEGVETQEQMIFLANIGCHVLQGYYFAKPMSAKELRKNS--------
>tr|K6YD73|K6YD73_9ALTE Diguanylate cyclase/phosphodiesterase OS=Glaciecola arctica BSs20135 GN=GARC_4935 PE=4 SV=1
-------------------------------------------------------LFLWQYRRAQNLRLHKAHQDAIQSKDKLTLALNASNSGIWEFQTE
QDIFFVS-RLGDELSSKK--TMSFE--DHLSLIHNKDKVLRSAWHDFLADNNAELDITYRMSTKDKTWLWFRDVGKVVETKAGKPLLLTGTYTNITETVA
VQENLRLFGEAFKHTLDWVIIYNHKYYPIAFNDAFKKYFDINDDVSAPKKLAKKIQTSETAMFWKK-LLTFEAGQHWQEEDKVLLPNGITLDIMVHLHAV
ASVHNKVEHFLVIISDITEQKAAEAKLLALANYDSLTGLPNRTLLLDRIDRGLEHARRNTKSMAIFFIDLDKFKQVNDSLGHKAGDELLVIIAKRLGDKL
RKEDTVARLGGDEFVIMIEDVTSEAISALVTEISDIIDIPVTLSSQSVSVSSSIGIAMYPGDGLSAEELLKNADIAMYHAKAQGRSNFQFFTQEMDELVK
GRLKLENQLKKAHQDKKFENYYQPILNTQTQKIEGFEILMRWPTR-NGMVSPDTFIPVSEELGLIEHMTLDAFERAMPVLNELRRGGF-NGYLSVNLSAK
HFDNQYSIDKIIFLLEQHKIPVTAIRFEITESALMRDYEKALIYMTQIQQKGFLIALDDFGTGFSSLKYLKEFPINIIKVDKSFVDDIGKNLNNEAIILT
TLSMAKQLKMSCVAEGIETIEQVEFFKKNQCQHLQGYYFSKPVPAADISALL--------
>tr|G7EQP5|G7EQP5_9GAMM Sensory box/GGDEF family protein OS=Pseudoalteromonas sp. BSi20311 GN=P20311_0996 PE=4 SV=1
-------------------------------------------------------FLFFWQYRSRKIAIERAHRAAIHSKTQTELALKSNKSGVWNYSFA
DNSV-NT-ARGEELGYENIPEIDIH--SFFNIMHPDERYRENKWNAFIKQQPQDWQATYRLRHKDGHWLWFHDLGQIIYNDSKKPEYVSGIFTNITEQLA
NEQQAKILGEAFSQINDFLLILDENLVPFSANSSFMEVFSDD-G-GGIVTSELKAIGQTKCKEFAATLKALQPKENWRTNAYVNTTKAKQHPIHLSATAV
ANEKGKVGYYVVVITDLTEQKRAENELRYLANYDALTGLPNRSLMNQKIENAITKAAKNDLQCAVIFIDLDKFKPVNDSFGHAVGDKLLCNITERVALYL
GDHATFGRQSGDEFLVLIENITSSSLQNTLNEMSSELASKVIIDDFSINISASIGIALYPHDANSTDALIRNADIAMMHAKQAGRNGFQFFNEKMNEQIK
QKLILENDLKDAAKDNQFFNHYQPVVNTKDKTISGVELLMRWENQ-GKLISPALFIPVAEETGLIDMLTEQALQRAITELAPILSVNP-QFYVSLNVSPK
HILKANITQRLSAILEKANIKPQQIRLEITENTLLEDKYKAAKQLKSLQAAGFKLFLDDFGTGYSSLTYLSQFPINVIKIDQSFVNSIGIDKGDESIIKT
IYSLAENLELYCIAEGVETREQLDFLTNIGCHKLQGYYFARPMSANDLMNPE--------
>tr|U1KH02|U1KH02_PSEO7 Diguanylate cyclase/phosphodiesterase OS=Pseudoalteromonas piscicida JCM 20779 GN=PPIS_03601 PE=4 SV=1
-------------------------------------------------------LLIIIKHKQKQRQLETALRAVTHAGRQTKLALKSTKSGVWSADLA
ARQI-TQ-QRAEALGFE--SDMTLQ--EHYNAIHPDDRELERAWKKFISNTKEQLSLSYRLRCADNNWHWFHDFGQVAEFSQGKATELHGIYTNVTTQKA
NQMRANMLGEAFSQVNDWILILDPNLQPISVNSSFCRAFQLQEHELNDLTTERNAIGQKKFHGLIANLKSLGPNQYLRQEVQVTDGWDKVHPVQLSISAV
SKDNVNLQYFVVVVTDLTEQKKAENELRYLANFDALTELPNRSLMLQHIEFALFNANNTQQSCALLFIDLDKFKPINDAYGHHIGDKLLVAITKRIKEQI
NNNCILARQSGDEFLVLIKSFPSEYVSEVVTRLVKHIPERIEIDGITMSVSASIGVAVYPFDAPDSESLIRNADIAMIHAKQSGRNAFKFFTESMNEEIS
KKLRLETAMKTAVKDGEFFNHYQPIINTTTGQLAGVELLMRWRNN-DMLIPPCDFIPIAEESGLIETLTEQALIRALIELRPLFTQEP-DFYLSLNLSAV
HILRSDIAHQFTEILKAHGLTNRCLRLEITESIFMSDMVKARATINEMKRADFVLLLDDFGTGFSSLTYLNEFPLDIIKIDQGFVRNMSAKPANKSIIRT
IYLLAQSLNMKCIAEGVETESQLNYLRDVGCEYMQGYHFAKPMAIDDLLAFY--------
>tr|A0A099LGI9|A0A099LGI9_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudoalteromonas sp. ND6B GN=ND6B_1419 PE=4 SV=1
-------------------------------------------------------FLFFWQYRSRKIAIEQAHRAAVHSKTQTELALKSNKSGVWNYSFA
DNSV-NT-DRGAELGYENLPEIDIS--SFFNIMHPDERRRQSKWNTFTNQKQKHWQATYRLRHKDGHWLWFHDLGQTIYNDTKEPLYVSGIFTNITEQLA
NEQQAKILGEAFSQINDFLLILDEDLVPFSANNSFMDVFSDE-G-EGVVTSKLNAIGQAKCREFATILKALKPKENWRTNAYVKTTKAEKHPIHLSATAV
ANEKDKVSYYVIVITDLTEQKRAENELRYLANYDALTGLPNRSLMNQKIENAITSAAKDDSQCAVIFIDLDKFKPVNDSFGHAVGDKLLCNITERVSQYL
GDDATFGRQSGDEFLVLVENVTSASLQHTLNEMSKELANKVIIEDFAINISASIGIALYPYDATSTDALIRNADIAMMHAKQAGRNGFQFFNEKMNEQIK
QKLILENDLKDAARDNLFFNHYQPIVNTLDKTISGVELLMRWENQ-GKPVSPALFIPIAEETGLIDMLTEQALQRAITELAPLLNINP-LFYISLNLSPK
HILKANITQQLSSILEKAQIKPQQLRLEITENTLLEDKYKAAKQLKSLQAAGFKLFLDDFGTGYSSLTYLSQFPINVIKIDQSFVNSIGIDKGDESIIKT
IYSLAENLELYCIAEGVETREQLEFLKNIGCHKLQGYYLARPMSANDLMSPE--------
>tr|A0A0B3XZL5|A0A0B3XZL5_9ALTE Diguanylate cyclase OS=Alteromonas marina GN=RJ41_15960 PE=4 SV=1
-------------------------------------------------------LVIYARRKKNSEVLRAAHSEALKHKNRLSMALTASNTKVWAWYED
SDKITQE-RIVDDLGYSDTETLSFR--EHISLVHNHDITSLEQWEKAVSGQSKGIDISYRMKAKDGHYEWFRDVGSLVENETENSKRLVGTYSNITESVN
AEFKARLFGEAFRYTRDWVVIFDSNFQPIVVNQSFKEALGINKDANLIEELELLGQKQQLEETYTE-MRKLGPNEHWSGEAYINSFTNQRYAVSIRVTAV
SSERQEIDRYLVILSDITQQKDAQNALVQLANYDNLTGLPNRTLLLDRLQHAFHQAASQQSKIGLFFIDLDRFKQVNDSLGHEAGDELLVTVSKRLEKLI
RKSDTVARLGGDEFVVLLEGVGSQDLGHIANDIIQALGQPITLSNQEVSVSASIGISLYPDDAQLPAELLKNADIAMYHAKEAGSNNFQFFTEHMNEQAR
SKLQLENKLKHACINKSFSNYYQPIVCCATGSIEGFEVLMRWKDG-DEMISPDIFIPVAENIGMIAEMTTQLIERALPVHQQLYAGNS-RAYLSINLSAK
HLINEYSLKDIVALLQSNGVPPENIRFEITESALMEDYDSAMHVIGALKSKGFIIALDDFGTGYSSLKYLKDFPIDVLKIDKSFVQGIGLNSGNEAIILA
TLRMAESLNIECVAEGIETLEQVEFFQRNGCRYLQGFYFSKPVAGDKLSGLI--------
>tr|W1YZE7|W1YZE7_9GAMM Diguanylate phosphodiesterase OS=Pseudoalteromonas sp. NW 4327 GN=X564_10130 PE=4 SV=1
-------------------------------------------------------CLLFWQYRSRQLAIANAQKATIHSQKQTELALSNNKSGIWDYHYS
DDSV-NT-NRGSELGYTNLPNIPLK--HYLALIHPEDKPRISHWLNFTKQKHEHWQATYRLKHKLGHWLWYQDLGQIIYDQTNKPVSVSGIYTNITEQRA
NEQQANILGEAFGQINDWLLILDNNLVPVSANNSFIKTFSQT-H--HPLSLKVNAIGKVQCKSYANTLKSLTAKQNWRTDAVIKTATNPHHPIHISATAI
AKDTHSISYYVIVISDLTEQKKAEDELRYLANFDPLTQLPNRSLMHQKIGKSIKKAHQQLTQSALLFIDLDKFKPVNDTFGHAVGDQLLCNITQRVSAML
PSNATLGRQSGDEFLVLIDNVEDAALNNIVKSISSELANKVIIEDFSINISASIGVALYPFDASSTDLLIRNADVAMMHAKQAGRNGFKFFNDSMNEQIK
QKLILENDLKDAAKDNLLFNHYQPIIDTHAQTINGVELLMRWENN-GQFVSPALFIPIAEETGLIEALTEQALERALTELAPTLASNP-LFYISLNLSPK
HILRTNIATKLTNILKQHQMTPVQLRLEITENILLEDKQKAAKQLQKLKSAGFKLLLDDFGTGYSSLTYLSQFPIDVIKIDQSFVNSIGIDKSDESIIKT
IYTLAQNLELYCIAEGVETKQQKAFLEGLGCHVLQGYYFAKPMRAEQLQNPE--------
>tr|U1LNE8|U1LNE8_9GAMM Diguanylate cyclase/phosphodiesterase OS=Pseudoalteromonas rubra ATCC 29570 GN=PRUB_23166 PE=4 SV=1
-------------------------------------------------------AMLYRRHQSKQLALQQTYDQLVHAKAQTDLALTKTQSGLWSMDMQ
TQQF-TL-LSNTQDTSQ--SKLSLT--VFFDKVHPQDQEMQRQWARFIASD-SQLSITYRIYSKQQGWLWYHDIAKVSEWAKGAPLKASGIYSNITEQKA
NQLNAAMFAQALSQIQDWLLILDSNLQLLSVNQSLSSSLGLDPYEQKQLTLSEQRLGRQQLIKLLNALRNILPKENIKLEIDVTFDDQRQSAVQLSINAI
TDEQGEIEFLVIVGSDLSQQKQAQSELRYLANFDALTDLPNRNLMLQHIEFAIYNATKSHSGCALLFIDLDKFKPINDAYGHSAGDQLLIAVTKRINSTL
NAHCILGRQSGDEFIVLIKTFEDAQVTELVQQMITSLCNKYEIDGISMSISASVGVAIFPFDEQTAEGLLRNADIAMLHAKQSGRNNFKFFTSEMNAHLS
RKLSLEAALKEAVADNQFYNHYQPIVNTTNHTLTGVELLMRWQLG-AKPVSPAEFIPIAEEVGLIEQMTTQALRNALEELTPFFHQQA-SFYLSLNLSPQ
HIMRDNLAPSLDSIVAEFGLSNHQLKLEITETSFLADRHKASKTLAQLKKFGFTLLLDDFGTGYSSLTYLSHFPIDIIKIDQSFIRTLETHPHNRSIVKT
IYMLAQNLNMACIAEGVETAQQLSFLRDLGCEYMQGYYFSKPLSAAGLFEQY--------
>tr|A0A099CSU2|A0A099CSU2_9GAMM Uncharacterized protein OS=Xanthomonadaceae bacterium 3.5X GN=LF63_0113130 PE=4 SV=1
-------------------------------------------------------LALYLAFRARRARERYHQDQLRQRESRLSMALWGSGDEFWDLDLN
RGRMYRL-GAEQLLGEGTPTEIDFD--WCNYVLHPQDLPHRKEIAACLNGDVDHFESEYRLKTTQGQWIWVLGRGKIVEQVEGRATRISGTVRNITRMRS
EDRDRRIAAEVIRSMSEAVTVSDLDFKFTSVNAAFTRMSGYSDSEVRGRDASLLNCNQQPDSIYTHMRRELQSHGHWRGELWQRRKNGSDFLCWVELREV
CNAHGTRTHYVCVMTDITDRKRAEQELRYLANYDMLTGLPNRTLLGERLGDSILRARRSSQRLAVLYVDLDRFKHINDSMGHTTGDRLLKAAGARLRQCV
REQDTVARVGGDEFTLVLEDIGGGEVIGVAHKIISAFNEALVLDPQEVLISPSIGISLYPDHGEVPNELLKHADTAMYQAKEHGRNTWMIYNDTMDADAR
LRATMAGALRRALERDEMRVVYQPKMALDDHELIGFEALVRWHSAELGEVGPGIFIPLAEETGMIMKIGQFVLERACQDLQAWREAGQNKLTMAVNLSMV
QLQRSGLAKRLQHTLQEHRVPPECLELELTESTVMANVEQSMRTLGELRAIGVSLAIDDFGTGYSSLAYLKRLPLTVLKIDQAFVGDITTDPDDEAITAT
IITMAHSLGLQVVAEGVESAEQAEYLQAHDCDLMQGNWLSPPLEADACLPFC--------
>tr|A0A0D6MF34|A0A0D6MF34_9GAMM Diguanylate cyclase OS=Mizugakiibacter sediminis GN=MBSD_1945 PE=4 SV=1
-------------------------------------------------------LAVYYVWRAKRREEQRHREQLQQREDRLRLALWGSGDEFWDWDMR
QGLLYRM-GADQLLGSRRGDRISAD--WRNFAVHPDDLPRERALADHVNGLTDHFEAEYRVINTRGEWVWTLSRGKVVERAHGQPLRVCGTARDVTFSRA
VERDRRIAAEVIRSMAEAVTVCDLDFRFVSVNQAFTRMSGYGEEEVLGQDATILNCHQHPPEAYEQVRRILVETGHWRGELWQRRKDGEEFLCWMELSEV
RDAGGARTHYVAVMSDITDRKRVEQELRYLANYDTLTGLPNRTLLGERLGHAIIRARRSGRKVAVLFLDLDRFKHVNDSMGHAAGDRMLKAAGARLRACV
REHDTVARLGGDEFTVVLEDIRDLDAEAMARKLLEAFGAPLELETQEVVISPSIGISLYPDHGQVPTDLLKYADTAMYQAKERGRNTWMVYTEAMDAQAR
MRATMIAALRRALERNEFSVVYQPKQSLADGRITGVEALLRWHSEDLGEIPPSEFIPLAEETGQIVEIGEFVLGMACAELARWREAGLRDLVMAVNLSVA
QLTRSELTGRLCDILAEHDIAPNQLELELTESMVMANAEQSVRTLGELKAIGVRLAIDDFGTGYSSLAYLKRLPIDSIKIDKEFVGDITSDPDDEAITAT
VIAMAHSLGLNVVAEGVETREQLEYLREQNCDEIQGHWLSPPLPPEACLAFL--------
>tr|A0A0A2X4H1|A0A0A2X4H1_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Lysobacter dokdonensis DS-58 GN=LF41_2063
-------------------------------------------------------GGVAWLIVQRRRREKVYFAQIRDREERLQLALWASGEMFWDYDLA
RGEMRSM-RTSESDAARPGIAVQSV--DQRHEIHDDDLPRLERLKQHLRGETPLFLSEHRVRGPNGAWTWVRARGRVVERPDGRALRVAGTARDITAGRA
AERERRIATEVLRSMSEAVAVLDRDFQFVSVNPAFSRISGYNETEVIGKSASLLDSAQHDPDFYRQTRAEVVRNGRWSGEMWQQRKDGEEFLCWIESSAV
LDAGGQRSHYVAVFTDITDKKRAEQELRYLANYDTLTSLPNRALLSERLSRAIVRARRQESRIAVLFLDLDRFKDINDSLGHAAGDRILRATAARLQQTV
GPQHTVARLGGDEFTVVLENIDTEEAEKIAREIITSFEAPLDIDEQDVAITPSIGISLYPDNAAVPTDLLKHADTAMYQAKAAGRRIYMRYTESMEIAIR
RRATISAALRKVLDRNELRLVFQPKLSLPQARITGVEALLRWTSPEYGEIPPAQFIPLAEESGLILEIGEWALREACHTLKRWRANGLDRLTMAVNVSAL
QLLRGDLPAVVARVLEDTGVPAEYLELELTESVVMSNAAQTAVTLQAIRELGVQLAVDDFGTGYSSLAYLKRLPITTLKIDKEFIGDLTRDADDEAITST
VITMAHSLGLNVVAEGVEEEAQVLFLRAHRCDEIQGYWLSQPLDAHRCLGLI--------
>tr|F4AJ30|F4AJ30_GLAS4 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Glaciecola sp. (strain 4H-3-7+YE-5) GN=Glaag_2666 PE=4 SV=1
-------------------------------------------------------LFIALSIVKQYRSKRIARLAITESEERLKLTLWSSGDELWDWDIY
QGQVFRS-NTWGIMDFPQDDI-RVS--AYQANIHQNDIKRQDALNEHLQDKTEHFEVTYRASTFKGEWLWVLDRGKVVSRSNNQPIRMTGTFKNISHLKV
AEEQLKLFKRSIETISDGVFIADTSFRYISVNKAYCKYTGETRDQALASYLTFHQ---YPGAFTEEVKKSLRQKGNWNGEVESRRINGEKYEMELNIDAI
NDEDGRISHYVGVFSDITPRKSTEKELLKLANTDPLTDLPNRSFFQASHNNIVR----RGTQHALICLDMDNFKKINDSLGHQTGDLLIKQIARRLQKLA
GKSATCYRLGGDEFSILLDKDTDHNVTHFSQSILDDLARPFLINHQEFVLGASIGIAFFPEDGSSPQELLKNADTAMYFAKNAGGNKYQFFSGEMNQNAV
RQLQIENLIRHGLKEDLFNVYYQPKIDIATGKLLSMEALVRFEHPEKGIVSPAQFIPLAEQTGQVIDIGEVVLRKACEDTKRWVKAGIFTGRVAVNISAR
QFELPDLDEKIADILQKADLSPLHLECEITEGTLMQDPDNALRMMTRLRERGIHLALDDFGTGYSSLAYLKRFPLNTLKIDKAFIDDIATSSVDRHMTAA
IITIAHNLGLKVVAEGVEHEEQMSILRRYECEMLQGYLYSKPLSSSRFERLL--------
>tr|K6Y4M4|K6Y4M4_9ALTE Sensory box protein OS=Glaciecola arctica BSs20135 GN=GARC_1919 PE=4 SV=1
-------------------------------------------------------ILILLYWFKQIRSRNAIRQSILENEERLKLTLWSSGDELWDWDIY
QGQVFRS-NTWGTLDFPQDNI-RVS--SYEANIHPNDIQRQQSLNEHLSEKTEHYEMTYRAKTYKGDWIWVLDRGKVVARNNHQAQRMTGTLKNISHLKE
AEEQLKLFKRSIETISDGVFITDTSFKYISVNNSYCNYTGETREQALVSYLTFHQ---YPGAFTEEVKKSLQQKGNWFGEVESRRSAGEKYEMELNIDAI
TDEDGKISHYVGVFSDITSRKITEKELLKLSNTDPLTDLPNRSFFQASHSNIVR----RDTHHALICLDMDNFKKINDSLGHQTGDILIKQIAKRLQKIA
GTKATCYRLGGDEFSILIDNSTDHHITHFAQTILDNMARPFIINKQEFVLGASLGIAFYPEDGSNTQELLKNADTAMYFAKNAGGNKYQFFSGEMNQNAV
RQLQIENLIRHGLKEDLFRVFYQPKVDIASGKLVSMEALVRYEHPEKGLVSPAQFIPLAEQTGQIIEIGEVVLRKACEDTKRWVDAGLFTGRVAVNIAAR
QFEIPDLDERITTILQKSGLSALHLECEITEGTLMQNPENALRMMQRLRERGIHLALDDFGTGYSSLAYLKRFPINTLKIDKAFIDDIATSAEDRHMTQA
IITIAHNLGLKVVAEGVEHENQLSILRRFKCEMLQGYLYSKPLNAAKFERLL--------
>tr|K6YF52|K6YF52_9ALTE Sensory box protein OS=Aliiglaciecola lipolytica E3 GN=GLIP_2633 PE=4 SV=1
-------------------------------------------------------ILVLLLMLRQYKRKLAVQNAIKESEERLKLTLWSSGDELWDWDVY
RGQVYRA-NTWGTMDFPQDGI-RSS--SYQANIHPNDMLRQEALQTHIDKKSDFFQVTYRARTFNGEWVWILDRGMIVKRNNDQPIRMTGTLKNISHLKQ
AEEQLKLYERSIETISDGVFIADTTFRFISVNQSYCEYTGETREQGLASYLKFNQ---YPEAFTEEVKKALRQKGNWNGEVESRRANGERYEMELNVDAI
HGEDGKTTHYVGVFSDITSRKSTEKELLKLANTDPLTEMPNRSFFQASHNNLVR----KDVPHALVCLDMDNFKKINDSLGHQTGDILIKHIGKRLQKIT
GTNATCYRLGGDEFSILVDREEDQRINHYAQRILDQMAHPFLINKQEFVLGASVGIAFYPEDGTSTQELLKNADTAMYFAKNAGGNKYQFFSGEMNQNAV
RQLQIENLIRYGLKDDLFTVFYQPKVDISSGKLVSMEALVRFEHPEKGIVSPAQFIPLAEETGQIIDIGEQVLRKACEDTKRWVSQGLFTGRVAVNISAR
QFELPDLDDRISRILQKVGLSPLHLECEITEGTLMQNPDQALQMMQRLREKGIHLALDDFGTGYSSLAYLKKFPLNTLKIDKAFIDDIATSSVDKHMTAA
IINIAHNLGLKVVAEGVEQEKQLEILRLYDCEMLQGYLYSKPLNSTKFERLL--------
>tr|A0A010PDE5|A0A010PDE5_9ALTE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Alteromonas sp. ALT199 GN=H978DRAFT_0657 PE=4 SV=1
-------------------------------------------------------LAIFAFILRQYQIRKANQLAIKESEERLKLTLWSSGDELWDWDVY
RGQVYRA-NTWGTLDFPQDDI-RTG--AYDANIHPSDITRKSALREHLEGNSDFYELAYRAKTFKNQWIWVLDRGKVVERHNEQPVRMTGTLKNIHHLKE
AEEQLNLFKRSIENISEGVFITNTQFKFISVNNAYCSYTGETRDQSLASYMHFHL---YPDAFTEEIKKTLKSKGNWSGEVESVRVNGERYEMELNIDAV
HDEDGKISHFVGVFSDITSRKSTEKELLKLANVDPLTELPNRSFFQASHQNLVR----KSSAHSLLCLDMDNFKKINDSLGHQTGDILIKQIAKRLQRIT
GRNATCYRLGGDEFSILMEDNADHTVTHYAQSLLDTLSRPFIINKQEFVLGASIGIAFYPDDGESPQEMLKNADTAMYFAKNNGGNSYQFFSGEMNQNAV
RQLQIENLIRQGIKDDLFTVYYQPKVDIASGKLVSMEALVRFEHPQKGIVSPGQFIPLAEQTGQIIEIGEQVLRKACADTKRWVNQGLFSGRVAVNISAK
QFELPDLDDRINRILSDVGLSPLHLECEITEGTLMESPENGLQMMTRLRERGIHLALDDFGTGYSSLAYLKRFPLNTLKIDKAFIDDIAKSNVDRHMAAA
IINIAHNLGLKVVAEGVEEESQLDILRRYDCEMLQGFLYSRPLNAERFEKLL--------
>tr|G4QKD6|G4QKD6_GLANF Sensory box protein OS=Glaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064) GN=GNIT_1208 PE=4 SV=1
-------------------------------------------------------VFLAVYQVSKMKSRKNRDQTLTEDVERLTLTLSSSGDELWDWDIA
SGQIYRA-NTWNTIDFPQDSM-RST--TYENNVHENDVERKQALDDHLEGKTQFFELAYRVKTFSGDWVWVLDRGKVVKRAHHNSLRMTGTLKNINHLKQ
AEEQLNLFKSSFENITEGVFIADQEFKFMSVNSAYCNCTGDTVEKALASKLSFSQ---YPEAFTEEVKKTLKHKGSWSGEIDAVRINGEKYQLEMTIDAI
RNEDNHISHYVGVFSDISSRKKTEKELLKLANTDPLTNLPNRSFFQASHENLVR----RETPHALICLDMDNFKRINDSLGHQTGDLLIKQIARRLQKIT
TSSSTTYRLGGDEFSMLIEATATHRISHIAQDILDALSRPFYINKQEFVLGVSIGIAAYPEDGTTHQELLKNADTAMYFAKNNGGSNYQFFSGEMNQNAV
RQLQIENLIRFGIKEDLFSVFYQPKVDIMSGRLVSMEALVRFEHPQKGIVSPGQFIPLAEQTGQILEIGEQVLRKACIDTKRWVDAGLFTGRVAVNISAK
QFELPDLDDRIERILKQVGLSPLHLECEITEGTLMENPEQALKMMQRLRERGIHLALDDFGTGYSSLAYLKKFPIHTLKIDKAFIDDIATSSVDKHMAES
IINIAHNLGLKVVAEGVEHEKQLEILKRYECEMMQGYLFSKPVSATKFEQLL--------
>tr|A0A099LEB7|A0A099LEB7_9GAMM Uncharacterized protein OS=Thalassotalea sp. ND16A GN=ND16A_0230 PE=4 SV=1
-------------------------------------------------------LLIIYYFVKQAQNKSMANIQIKESEERLKLALWGSGDEMWDWNLV
TNQMYRS-NIWGILDFPMEGSLEDG--EKRRNIHPQDYPRKQLLLEHKEGKSEHYEAAYRVKDKSNNWLWVLDRGKVVERANEAPVRMTGTLKDISQIKA
NEESLKLFAKCIETISDAVVVYDHQFNLVDCNISYQTITGQSRPEALGQELAFNS---YPDSFLQNLKKNLLLHGTWQGEIESTRPTGQFYLIDITIDII
RDENDKISHFVGVFSDITKRKETEAELRKLANSDTLTGLPNRSFFQATHTQLVE----QDVDHALLVFDLDNFKKINDSLGHQIGDVLLCKVTERIATIG
NIKDTCYRLGGDEFALILEGTNDHNITSIADEILNTVVEPYSIRQQEISLSCSIGIVLFPDDGSNTHELLKNADTAMYHAKDKGGDTYQFFNDSMNKQAV
KRLQIENLIRYGLKEDLFTVFYQPKIEVASGKVKGMEALVRFEAGSKGIIRPDIFIPISEETGQIIEIGEIVLRKACLATKAWLDNGMFSGRIAVNLSAV
QFRQHNLVQIISEILEETKLPAKHLELEITEGTVMNSPKEAIETMLQIRKMGIHLSLDDFGTGYSSLAYLKKFPLNTLKIDKAFVDDIEISEEGRNMVAT
IVTIAHNLGMDVVAEGVETESQLTYLKEVNCEQMQGYLYSRPLAEEDFGRYL--------
>tr|K2L1S8|K2L1S8_9GAMM PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Idiomarina xiamenensis 10-D-4 GN=A10D4_06626 PE=4 SV=1
-------------------------------------------------------LVALLILTHIFNARRQNARQLLHSEERLKLSLWGSGDQLWDWDIP
NHVLFRQ-NTWRHTEFPIDGEVGTE--QQPSNIHPQDKARQEALRDHLQGLSEHYEVTYRVRH-GEQWLWLLDRGKVVARESGQATRMTGTLKDITDIVA
AQERIRMLATSLTNISDGICIYDQRFIICEVNNAFERITGFTREQVINQSFKLPL---YKPAYIEQIKQRLASEGSWHGEVMDKRADGSTYQMELTIDCV
RDDAGDISLYVASFSDISERKAAEVELRRLANTDTLTGLPNRSYFQVSHSNLVR----KRLKHALLVFDLDNFKKINDSLGHEVGDHLLCQVAERLSDIG
RAQDTLYRLGGDEFGLLLEDCTDTVITSTAKTINQRLAKPFHIAEAEVVVTSSIGIVVYPNDGNSSQELLQNADNAMYHAKREGGDRYQFFSESMNQNAV
RRLQLEGQLRRALKQNHLTVYYQPKVDIASGNICGLEALARIELPDGQVISPADFIPLAEETGLIVELGEKVMRQACRDMKAFLASGLQHSRVAVNLSAR
QFALTDLSQRLLNILQQEQLAPQMLELEITEGIVMPDPEHAITLMTALSEQGIHLALDDFGTGYSSLAYLKRFPIHSLKIDKAFVDDISHNDIDRNMVAS
VVAMAHHLQLTVVAEGVESADQLAVLRTLGCDQAQGYYFAKPLNASEFRQQW--------
>tr|Q0HWN0|Q0HWN0_SHESR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella sp. (strain MR-7) GN=Shewmr7_1476 PE=4 SV=1
-------------------------------------------------------MLFSLFIFKAILRKREIQRQIALSEERLKLSLWGSGDEMWDWDIE
TGNIFRS-NIWGALEFPRDGHSGNS--DEESNIHPMDQERREALNKHFYGETDHFEAAYRVKGKDDSWIWILDRAKIVERDKDNALRMTGTIKNISQFKQ
KEEQLKLFEKAIENISEGMFILDSEYRFVEVNEACCRISQRNRTDFIGNLLTFDL---YPESFTNQIRTMLKQQGRWASEVEASRGDKSHFHMELTIDAI
YDELGELSHYVGVFSDISRRKQQEEELRKLTNNDLLTGLPNRSNLQVTLGNLVN----KEITHALMVLDLDNFKRINDSLGHQIGDQLLKLVSVRIKSVV
PKNTSIYRLGGDEFAIVLDKTSDSACAAIAGRVIEAFKTIFEIGNEQLVLGVSIGIVFYPEDEQSEQALLRKADIAMYHAKSAGGNCYQFYSESLNQHAI
KQLEIENLIREGLKEDLFEVYYQPKVDLKSGHVAGMEALVRLNHPTRGLVPPNDFIPLAEENGLIIEIGEIVLRKACFAAQKWREQGLFKGRVAVNLSSR
QFALPDLQQRIEAILRLTQLPAAHLELEITEGTVIKQPEMAITVMQQLAKMGVSLALDDFGTGYSSLSYLKRFPIHTLKIDKAFVDDIDKSDRDLKMVDS
IITIAHNMGLSVVGEGVEQAAQLNILRALNCEEIQGYIFSKAINETEFTQLL--------
>tr|A8H5S6|A8H5S6_SHEPA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella pealeana (strain ATCC 700345 / ANG-SQ1) GN=Spea_2593
-------------------------------------------------------IFISILIIKTILRRREIQRQIAKSEERLKLSLWGSGDEMWDWDIE
TGQIYRS-NIWGSLEFPQDGQSGNN--GEESNIHPMDQERREALNKHFYGETDHFEAAYRVKGKSNDWVWILDRAKIVERENDNALRMTGTIKNISNFKQ
AEEQLRLFERAIQNISEGMFILDRNFKFVEVNEACCDLSMMSKNELIGTLFNFDL---YPDSYSEQIRSILKQQGRWNNEVESIRGNGSSFLMELSVDAI
YDEQGELSHFVGVFSDVSRRKQQEEELRKLTNNDLLTNLPNRSNLMVTLGNLVK----RDSHHTLMVLDLDNFKKINDSLGHQAGDELLVQVSERIQVAV
PSHTSIYRLGGDEFAILVDKNPDGTSAIIAKNVIHAFEASFELSSEKVVVGLSIGIVLYPEDDQNEQALLRKADIAMYHAKSAGGNRYQFYSESLNKNAI
RQLEVENLIRDGLKDDLFEVYYQPKVDLKTGHMAGMEALVRLNHPELGLIAPNEFIPLAEENGLIVEIGDVVLKKACFAAQKWRSQGLFNGRVAVNLSSK
QFALPDLQQRVESILRLTQLPAANLELEITEGTVIKEPEKAIKVMQQLSKMGVSLALDDFGTGYSSLSYLKRFPIHTLKIDKAFVDDIDKSDRDLKMVDS
IITIAHNMGLSVVGEGVEDASQLSILRALKCEEIQGYIFSKPVTESKFTLLL--------
>tr|A1S7L3|A1S7L3_SHEAM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) GN=Sama_21
-------------------------------------------------------LLITSGIIKAALRRREVQRQIAISEERLKLSLWGSGDEMWDWDIE
TGKIYRS-NIWGSLEFPKDGHSGKD--DEESNIHPQDQERREALNRHFYGETDHFEAAYRVKGKDGHWVWILDRAKIVERDSENALRMTGTIKNINNFKQ
AEEQLRLFERAIENISEGMFILDHEFRFVEVNEACCDICLMDKDSFIGTQLQFSC---YPDAYSEQVRIILRQQGRWSAEVESRRGDNSTFLMELTVDAI
YDEQGTLSHFVGVFSDISRRKQQEEELRKLTNNDLLTGLPNRSNLQVSLNNLVK----KDTHHTLMVLDLDNFKKINDSLGHQVGDELLQLVSRRMSAAL
PGHTSLYRLGGDEFAVLLDKDPDGSAAAIAKGLVDAFVAPFELAGEKLVVGVSIGIVLYPEDEQNEQALLRKADIAMYHAKSAGGNRYQFYSESLNRNAL
RQLEVENLIRDGLRDDLFEVYYQPKVDLRNSRMAGMEALVRLNHPTQGLIPPSEFIPLAEETGLIVEIGDLVMRKACFAAQRWREQGLFDGRVAVNLSSR
QFALTDLQQRIESILRLTKLPAANLELEITEGTVIKQPEKAIKVMQQLAKMGVSLALDDFGTGYSSLSYLKRFPIHTLKIDKAFVDDIDKSDRDLKMVDS
IITIAHNMGLTVVGEGVEVPSQLNILRALKCEEVQGYIYSKAVPEAEFTTLL--------
>tr|A0A0C3LTQ2|A0A0C3LTQ2_9GAMM Contig_18, whole genome shotgun sequence OS=Shewanella sp. cp20 GN=DB48_06645 PE=4 SV=1
-------------------------------------------------------LLITGAIVKAALRRREVQRQIAKSEERLKLSLWGSGDEMWDWDIE
TGQIYRS-NIWGSLEFPRDGQSGED--GEESNIHPMDQERNTALNKHFYGETDHFEAAYRVKGKDDQWIWILDRAKIVEREEDKALRMTGTIKNISNFKQ
AEEQLRLFERAIENISEGMFILDNKFTFVEVNEACCDLCEKSRNDFIGELFKFDL---YPESYSEQIRHILQQQGSWSNEVESAKGDGSSFLMELTVDAI
YDEQGVLSHYVGVFSDISRRKQQEEELRKLTNNDLLTSLPNRSSLMVTLGNLVK----KDTHHTLMVLDLDNFKKINDSLGHQVGDELLIKVARRIESTV
PYHTSIYRLGGDEFAILVDNNPDGSSAVIANHVVDAFSSPFELTKDRVVVGVSIGIVLYPEDDQNEQALLRKADIAMYHAKSAGGNRYQFYSESLNRNAI
RQLEVENLIREGLRDDLFEVYYQPKIDLRSSKMAGMEALVRLNHPEHGLIPPGDFIPLAEENGLIVEIGEVVLRKACFAAQNWRRQNLFNGRVAVNLSSQ
QFALPDLQQRIESILRLTQLPAANLELEITEGTVIKQPEKAIKVMMQLSKMGVSLALDDFGTGYSSLSYLKRFPIDTLKIDKAFVDDIDKSDRDLKMVDS
IITIAHNMGLSVVGEGVEEASQLSILKALKCEEIQGFIYSKAVNETSFTELL--------
>tr|Q12P09|Q12P09_SHEDO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15
-------------------------------------------------------LLFSSALVRAIMRRRVIQKQIALSEERLKLSLWGSGDEMWDWDIE
SGKIYRS-NIWGTLEFPQDGQSGDV--DGESNIHPQDQARQQALDDHFEGETDHFEVAYRVKNRNNEWLWILDRAKIVERNKERPLRMTGTIKDINNIKQ
TEEQLRLFARAIENISEGMFILDAEHRFLEVNSACCSLLQRTKSSFTGELLSFNL---YPESFSTQIRSIITQQGYWSGDVDALKSDDSTFLMSLTIDAI
KDELGLFSHYVGIFSDITRRKQQEEELRKLTNNDILTGLANRSSLQVTLSNLVK----KDIHHTLMVLDLDNFKRINDSLGHQIGDSLIISVAERIQAII
PSHASLYRLGGDEFAILLDKNPDASSAAIAGSVIKDLKTPFSIESEQLVIGISIGIVLYPEDEQNEQALLRKADIAMYHAKSAGGNRYQFYAESLNQNVL
RQLEVENLIRQGLKEDLFEVHYQAKVDLKLDRITGMEALVRLNHPQLGLIPPNDFIPLAEDNGLIIEIGDIVLRKACTAAQSWRQQGIFNGRIAVNLSSK
QFALPDLVQRIESILCQTGLPAENLELEITEGTVIKNPESAIKVMQQLAKMGISLALDDFGTGYSSLSYLKRFPIHRLKVDKSFVDDIDKSDMDLKMVDS
IITIAHNMGLTVVGEGVEQAAQLSILKALNCEEIQGYIFSKPIKESEFTQLL--------
>tr|Q07ZQ2|Q07ZQ2_SHEFN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella frigidimarina (strain NCIMB 400) GN=Sfri_2672 PE=4 S
-------------------------------------------------------LSLIILSFKVIIRRREIQKQIAQSEERLKLSLWGSGDEMWDWDIE
SGKIYRS-NIWGSLDFPQDGRSGNP--DEESNIHPLDRDRTRALNDHFNAITDHFEIAYRVKARNQQWVWILDRAKIVERQKDVPLRMTGTIKDINNIKQ
AEEQLRLFARAIENISEGMFILNEKYQFVEVNNACCELAASTKEKFANEILHFSR---YPASYSEQIRNLLKQQGRWSGEIEASKGKDSYFLMELTIDAI
YNEQGETSHYVGVFSDITRRKQQEEELRKLTNNDLLTGLPNRSSLQVTLSNLVK----KDVHHTLMVLDLDNFKRINDSLGHQIGDDLLIGVAERIKLAI
PKHASLYRLGGDEFALLVDQHPDGSCAAIATQVINCLKPAFTLNNDSLVLGISIGIVLYPEDEQNEQALLRKADIAMYHAKSGGGNRYQFYSESLNQNAL
RQLEIESLIREALKDDLFEVYYQPKIDVKKDRLNGMEALVRLNHPKLGLIGPNEFIPLAEENGLIVEIGDVVLRKACFAAQKWLELGLFSGRVAVNLSSR
QFALPDLQQRIESILRLTKLPAKHLELEITEGTVIKDPEQAIKVMQQLAKMGVSLALDDFGTGYSSLSYLKRFPINCLKIDKTFVDDIDKSDRDLKMVDS
IITIAHNMGLTVVGEGVEQTAQLNILKALNCEEIQGYIYSKPIREADFELML--------
>tr|A9D7A1|A9D7A1_9GAMM Sensory box protein OS=Shewanella benthica KT99 GN=KT99_09903 PE=4 SV=1
-------------------------------------------------------LIISAVIVKTILRRREVQKQIAKSEERLKLSLWGSGDEMWDWDIE
TGQIYRS-NIWGSLDFPRDGQAGET--GEKSNIHPMDQKRSTALNDHFSGKSDHFEAAYRVKGKSGDWVWILDRAKIVEREKDNPLRMTGTIKNINNFKH
AEEQLRLFERAIANISEGMFILDSEFRFVEVNEACCELCLKPKDKFIGEQFNFDL---YPDSYSEQIRTILNQQGRWSNDVESAKGDGSSFLMELTVDAI
YDEQGQLTHYVGVFSDISRRKQQEEELRKLTNNDLLTNLPNRSSLMVTLGNLVK----RDSHHTLMVLDLDNFKKINDSLGHQVGDELLIKVARRIEAAV
PYHTSIYRLGGDEFAILVDDNPDGSSAVIANSVIEAFVTPFELTSDKVVVGMSIGIVLYPEDDQNEQALLRKADIAMYHAKSAGGNRYQFYSESLNRNAI
RQLEVENLIRQAIKEDLFEVYYQPKIDLKSGKMTGMEALVRLNHPEQGLIPPNEFIPLAEENGLIVEIGDIVMKKACFAAQKWRSQGIFNGRVAVNLSSY
QFALPDLQQRIESILRLTQLPAANLELEITEGTVIKEPEKAIKVMQQLSKMGVTLALDDFGTGYSSLSYLKRFPIHTLKIDKAFVDDIDKSDRDLKMVDS
IITIAHNMGLSVVSEGVEDASQLSILKALNCEEIQGFIFSKPVTEAEFTKLL--------
>tr|B1KKS6|B1KKS6_SHEWM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella woodyi (strain ATCC 51908 / MS32) GN=Swoo_3022 PE=4 
-------------------------------------------------------LIISAVIVQGILRRREVQKKIAKSEERLKLSLWGSGDEMWDWDIE
TGQIYRS-NIWGSLEFPKDGQSGDA--DEESNIHPMDQDRTKALNSHFDGNSDHFEAAYRVKGKSDEWVWILDRAKIVEREKDNPLRMTGTIKNINNFKN
AEEQLRLFERAIANISEGMFILDNNFIFVEVNEACCELSLIPKEQFIGSLFKFNL---YPDSYSEQIRSILHQQGSWSNDVESAKGDGTSFLMELTVDAI
YDELGQLSHYVGVFSDISRRKLQEEELRKLTNNDLLTNLPNRSSLMVTLGNLVK----RDTHHTLMVLDLDNFKKINDSMGHQIGDELLIKVAKRIEAAV
PYHTSIYRLGGDEFAILVDNNPDGSSAVIANNVIDAFASPFELTSEKVVVGLSIGIVLYPEDDQNEQALLRKADIAMYHAKSGGGNRYQFYSESINRNAI
RQLEVENLIREGLRDDLFEVYYQPKIALKTGRMAGMEALVRLNHPEHGLIPPSEFIPLAEENGLIVDIGDLVMRKACFATQKWRSLGLFDGRVAVNLSSY
QFALPDLQQRIESILRLTQLPAANLELEITEGTVIKQPEKAIKVMQQLSKMGVSLALDDFGTGYSSLSYLKRFPIHTLKIDKAFVDDIDKSDRDLKMVDS
IITIAHNMGLSVVGEGVEDASQLSILKALKCEEIQGFLFSKAVTETQFSELL--------
>tr|A0A094LRY5|A0A094LRY5_9GAMM Diguanylate cyclase OS=Shewanella sp. YQH10 GN=HR45_05390 PE=4 SV=1
-------------------------------------------------------SLIVIFLIKAILRKRQIQRQIAQSEERLKLSLWGSGDEMWDWDIE
TGKIYRS-NIWGALEFPMDGQSGKD--GEESNIHPQDQLRREALDKHFVGETDHFEATYRVRSKNGDWLWILDRAKIVERDKDQPLRMTGTIKNINSFKT
AEEQLRLFERAIENISEGVFILDIDFNFVEVNEAACDITRYTHDEMVGVPLYFAK---YSEDYNKQIVLLLKQQGRWNTEIEVIRGDSTEFLMELTIDAI
YDEQGVLTHYVGVFSDISHRKKQEAELRRLTNNDLLTGLPNRSNLQVTLENLVK----KDSHHTLMMMDLDNFKKINDSLGHQIGDELLKNVATRLRKVV
PKHTNLYRLGGDEFAILIDNNPDGSSAIIANDIIEAFRAPFELSEEILVVGVSIGIVLYPEDEQNEQALLRKADIAMYHAKSAGGNRYQFYSESLNRNAL
RQLEVESLIREALRDDLFEVYFQPKISLATTKLAGMEALVRLNHPKHGLISPAEFIPLAEETGLIVEIGDVVLKKACFAAQGWREQGLFNGRVAVNLSSR
QFALPDLQTRIETILQLTKLPASNLELEITEGTVIKQPEKAIKVMHQLAKLGISLALDDFGTGYSSLSYLKRFPIHTLKIDKAFVDDIDKSDRDLKMVDS
IITIAHNMGLSVVGEGVEQTAQLNILRALKCEEIQGFIYSKAISRDDFTSYL--------
>tr|E1SQ56|E1SQ56_FERBD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Ferrimonas balearica (strain DSM 9799 / CCM 4581 / PAT) GN=Fbal
-------------------------------------------------------LALVLVVYREFLRRQRVQARIAQSEERLKLSLWGSGDEMWDWDME
AGRIYRS-NIWGILEFPRDGKSS----GAESNIHPDDVERNQLLSRHFSGDSDHFEATYRVKSKLGDWVWILDRAKIVERDQDRPTRMTGTIKDISSIKE
AEERLNLFARALRNISEGMFILDDDMRYLEVNEACLEITGFEKEHFVNETLKFDR---YPQAYTDDIIRIVQQQGRWNGELELSRSNGRLIQIELTLDQI
KESGTHNHFYVGVFSDITHRKQAESELRRLTNNDILTGLPNRSYLQISLDSLVR----RQVPLCLLIFDLDNFKKVNDSLGHGAGDALLCHVANRVRNHL
PEQASLYRLGGDEFAVIFDGDQANYSTKLAQEILAAFSQPFQLEQGEVVVNSSIGIVTFPDDDVDRQALLRKADLAMYHAKGQGGQCYQFFNESLNQAAM
ERLDTENLIRQALKDNHFEVYYQPKVDLPTKQIKGMEALVRLNHPTRGLISPGEFIPLAEETGLIVEIGEHVLKQACFAAEKWRQMGLLKGRVAVNLSSQ
QFILPDLCERIERILKLTRLPADWLELEITEGTVIQQPEQAIATMRTLNQLGIHLALDDFGTGYSSLSYLKRFPINTLKIDKSFVDDIAITAKDRMMAAS
IITIARNMELSVVAEGVEEKAQLSVLEELRCDMVQGYLFSRPIPEMEFESLM--------
>tr|C7R9A3|C7R9A3_KANKD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Kangiella koreensis (strain DSM 16069 / KCTC 12182 / SW-125) GN
-------------------------------------------------------LAFSYLIWARMRERRMAALQLTQSEERLKLSLWGSGDELWDWQVQ
SGALHLS-NEWPY-DFPRDGISGYS--MANSNIHPNDLPYRQSLNAHLADKSMHYESTYRISDEHGGWIWVLDRGKVVSRENQKPLRMAGTLKNITELKN
TEQQLSMIVKSFDNISDGVWILDENFHYIAVNKAFTKITGFDESEVLGKLMKVSSLHQITDDEFYDLRNELTEKGFWYGELVAKRKDGDTYPIEINIDVV
RDNDGEIINYVGVFSDITFRKQAERELRRLATVDQLTDLKNRTSFRTLFEHLIED-SGRGDQHALLFIDLDNFKRINDSLGHGIGDELLIYVAKILQEIV
SDNGVVARLGGDEFTVLLQEVDTNKPAKIAQAILDEFAKSLPLSTAEVVVSPSIGIVMYPENGTSAEELLKNADTAMYYAKKKGKNTYQFYTRQMNEQAK
LRITLESELRQAIEKDEFVMFYQPKVSLQTGKITGMEALVRWRNPRRGLVLPGEFIPLAEEAGFIIPISQRVIEKTCLQIRDWQNRGIFHGKVAVNLSAV
QFYHENLWETVKNALHLAKIEPDALEFEITEGMVMEDLAQSLQQMRTLREMGISLALDDFGVGYSSLGNLKDFPIDTLKIDRTFVWDLEDSDRDRNLVAS
IVTLAHNLDIKVVAEGVENRNQVDALREMGCEEIQGFIFSRPVPPWDIETML--------
>tr|K2KFW6|K2KFW6_9GAMM PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Gallaecimonas xiamenensis 3-C-1 GN=B3C1_04935 PE=4 SV=1
-------------------------------------------------------FFIALHILSIVRTRRRQHARIVESEERLKLALWGSGDELWDWDIE
NGNIYRS-NIWDTLLLPDDGVT--A--DNKNNIYPKDLARKSTLNACFSGEQDEFEIAYRVKGKEDDWVWILDRGRVVEYDRGAPVRMTGTIKNISKLKK
TEEKLKLLAQSFRNISDAICITSPDFIIQDINDSFTRVTGTSRQDAIGKPWNFSL---YNERFMEQIKQALEKSGRWHDELEARRNSGEIYPIEITIDRV
MDDEKDSFHFVAVFSDISERKEKERELERLTNTDPLTGLPNRSFFMSTLHGLVR----KKQPCALMVLDLNNFKQVNDSLGHQYGDQLLLEVADRLQYVM
GQEHTLYRLGGDEFAIVVDSQAKDDITRLSAALHRQLMAPFYLHGEEINVTCAIGAVLYPDDGDNPENLLRNADAAMYHAKHVGGDICQFFSTTMNEQAH
ARLALENRVRKALRENLFEVFYQPKADTYSGQCKGAEALLRLPDGRGGYISPADFIPIAEESGLIVDLGNWVMHATCRQVCKWYDQGLFPGRIAINLSPR
QFRQQDLVARIDEVLETCGLPPHLLELELTEGAMMEDPIRAIAVMERLRERGITLAMDDFGTGYSSLSHLRQFPVTSVKIDRSFVKDLTVDTSARSLTAA
IISLAKNMELQVVAEGVETEEQLTALKQLNCPISQGYLFGKPMPAMDFEQLL--------
>tr|Q5QXM2|Q5QXM2_IDILO Signaling protein with a ligand-binding sensor domain, PAS, GGDEF and EAL domains OS=Idiomarina loihiensis (strain ATCC BAA-735
-------------------------------------------------------ILCLFSYWLYQRQRQAKMRHDLKQYRRQAQGVLSSRYQCWEWDLE
SGELIRQ-NIWDNPAFSIDGILGLS--GGKSNVHPEDLKRQKSLEDHLSGESELFECSYRLDN-QGNWLWVLDRGKIQVNE---RRTMFGTLSDISRLVS
SEERITMLASSITNISDGICIFDRFFRKREVNNAFERISGFSRDQVLGQLLTLEC---YPESFVNQIKRSVIKEGTWRGEITDVKANGEEFLMELTLDAV
RDDNGEVSLIVASFSDITERRHTENELRRLSNTDTLTGLPNRSYFQVSHSNLVR----KKVSHTLLLFDLDDFKKINDSLGHEIGDELLCQVAERLMDIG
RRQDTLYRLGGDEFGLLIEDSVDNLIGDLANQINLKVAEPYFIEQHEIVIGSSIGIVLYPHDGQTSQELLQKADMAMYHAKQRGGNCYQFFSQSMNENAV
KRLKLENELRAALKSHNIRVYYQPKIEIHSGHIAGLEALARIESEDGSMINPADFIPLAEETGLIIPLGEEVLRLACRDMKRFMACQGSPKSIAVNLSAR
QFMQSSLALQIEQILREEGLHPRHVEFEITEGMVMSDPERAITMMENLSDMGVKLALDDFGTGYSSLSYLKRFPMNSLKIDKAFVDDITINDKDRNMVAS
IIAMAHNLGLKVVAEGVETKAQLQTLKSLKCEYIQGFYFAKPMPADALIEFI--------
>tr|G0AT78|G0AT78_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella baltica BA175 GN=Sbal175_0359 PE=4 SV=1
-------------------------------------------------------AWVILWRKKKHQIQREFETSIRASEERLKLALWASGDGMWDWNIP
ENQVYRT-NM--DSSIPHWN---SN--IVHESMHSEDRERKLELNEHLQGRSPFFEAEYRVERSPGNWVWILDRGKVVEKSLDNPIRMTGTNRNITSRKL
IENELVLSSQVLNSMNEAVVVAGLDYRIRSVNPAFCAITGYTERQITDRHFIHLAFGRQQRELFNTIEQQLLRHKHWVGELWIRNKQRQAILVWLEINQV
IDIKGETSHFVAVFTDITQRKKAEEDLRFLASFDTLTGLPNRTLFQDRLNHAITQAHRANNIVALLFLDLDRFKHINDSMGHHVGDLLLKAVARRLQNAV
RDGDTVARLGGDEFTIILEGVAKKAATLISEKVLRAFQTPFLLDDKTLTISTSIGISLYPNDADNADSLIKFADTAMYHAKSSGRNNFQFYTSKLNEIAT
RHVQLESGLKEAIQRNELSLVYQPKFCLKDGSLTGIEALLRWHHTELGPISPVEFIPLAEETGIITQIGHWVINQACQQLAEWNSLGFNGITVAVNLSAR
QLKA-DIISTIEVALAVSGLPAQSLELELTESMIMGNPQESVSILSKLKALGLTIAVDDFGTGYSSLSYLKRFPIDTLKIDREFVRDITNDPDDAAITSA
IIALAHSLDLNVVAEGVETQEQLNFLAMQGCDQVQGFLLSKPLSAADFLTLL--------
>tr|Q12IM7|Q12IM7_SHEDO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15
-------------------------------------------------------LQAIHSRQKKQQKQNEFETSIKASEERLKLALWASGDGMWDWNIP
DNQVFRT-NM--SNPQSLSR---SS--TLINSIHPEDRPKQLLLNEHIAGNSEFYEAEYRIRDEVGSWIWLLDRGKVVEKTNGAPIRMAGTHKDITSRKV
IENELKLSSQVLYSMNEAVVVGELDYRVRSVNPAFTRITGFEPDEVTNKHFLFLAISSQGRDFYNQVETQLLKHKHWAGELKIRTRDKKGILAWLEINQV
IDNKGETSHFVAVFTDITARKKAEEDLRILANFDPLTHLPNRTLFQDRLDQAITKAHRNQNIVALFFLDLDRFKHINDSMGHHIGDLLLKAVAHRLQRAV
REGDTVARLGGDEFTIILEGVTKNAVTLVAEKILNAFQKPFLLDDKNLTISPSIGISLYPDDANDVSSLIKYADTAMYHAKSVGRNNFQFYTDQLNQYAT
RHVQLEAGLKLAIQENELSLVYQPKYDIFTKKIVGFEALLRWNNPSLGFISPAEFIPLAEETGFINQIGHWAINQACNQLAQWHELGFRDVSIAVNLSAR
QLKA-DIISTIEVALAVSGLPASALELELTESMIMGNPQDSVAILSQLKSLGLTIAIDDFGTGYSSLSYLKRFPIDTLKIDREFVRDITEDPDDAAITSA
IIALAHSLDLNVIAEGVETPEQLDFLLNEGCDQVQGFLLSKPLSAKDALALL--------
>tr|Q8EJW5|Q8EJW5_SHEON Multifunctional sensory protein/diguanylate cyclase/signalling protein with EAL domain OS=Shewanella oneidensis (strain MR-1) G
-------------------------------------------------------GWALRWRKQKRSQQQEFETSIRASEERLKLALWASGDGMWDWNIQ
EQQVYRT-NT--DIAVPQWN---GQ--LLHDNAHPEDRERKYELTEHLQGRSPFFEVEYRIEHSPGKWVWILERGKVVETAQERPIRMTGTTRNITSRKL
IENELVLSSQVLNSMNEAVVVAGLDYRIRSVNPAFSAITGYSEGQISDKFLIHLAYSRQQRDLFNSIEQQLLRHKHWAGEIWIRNKARRAILVWLEINQV
IDVKGETSHFVAVFTDITERKKAEEDLRFLASFDTLTGLPNRTLFQDRLNHAISQAHRSNNIVALLFLDLDRFKHINDSMGHHIGDLLLKAVAHRLQSAV
REGDTVARLGGDEFTIILEGVAKKAATLISEKVLKAFQAPFLLDDKSLNISTSIGISLYPNDAKDVDSLIKFADTAMYHAKALGRNNFQFYTNKLNEMAT
RHMQLETGLKQAISHNELSLVYQPKFCLRNGSLTGLEALLRWQHSELGPISPAEFIPLAEETGMINQIGHWVINQSCQQLAEWNELGFSDISMAVNLSAR
QLKA-DIISTIEVALAVSGLPAKALELELTESMIMGNPQESVNILSKLKALGLTIAVDDFGTGYSSLSYLKRFPIDTLKIDREFVRDITNDPDDAAITSA
IIALAHSLELNVVAEGVETQEQLNFLALQGCDQVQGFLLSKPLSAQDCQTLL--------
>tr|A0A094LNQ1|A0A094LNQ1_9GAMM Uncharacterized protein OS=Shewanella sp. YQH10 GN=HR45_14135 PE=4 SV=1
-------------------------------------------------------AYIARHLTRKWQKERQVQQQINDSRERFKLALWGSGYRLWDWHLA
SNLLTIT-QLSQDDELSQEL---DQ--QYLALIHPEDRPQQQALTDYFDDKTPFYEAEYRVFSPEGQWEWAVERGKVSERKQGNPVRMAGTYTNVSIRKQ
QEDELKLSYQVLASMNEAVVICDLDYRVISVNPAFIDMTGYSEQFIEGKYCLALTRGLYQVTDYRNIENELLRDRHWSGEMRLRRANGDTILIWLEINQV
LDSKGEASHLVMVFTDISDRKKAEEDLRLLANYDPLTGLPNRTLFKDRLKHALEQAQRNNTKVALLFLDLDRFKNINDSKGHHVGDQLLKAVGKRLAGVI
RAGDTVARIGGDEFTIILEGVAKKAATVIAEKIIDVLDQPFELSHTTLDITTSIGISLAPDDATDAQELLKYADTAMYHAKSLGRNNFQFYTAHLNVSAV
RHLQLETGLKQAISKNELYVLYQPKFCINSGKIMGLEALMRWHSEELGPVSPAEFIPLAEETGQINALGSWLLQHVCRQLADWLTAGHPVVPIAINLSAK
QLQL-AIIDEIELTLRDYQLPANLLEIELTESAVMQHPKQSISILNRLEQLGLSLAVDDFGTGYSSLAYLKRFPINTLKIDREFVRDISEDPDDAAITNA
IIALAHSLELLVVAEGVETEEQLQFLASQGCDQVQGFLLSKPLTAADSLKRL--------
>tr|A4YBM3|A4YBM3_SHEPC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella putrefaciens (strain CN-32 / ATCC BAA-453) GN=Sputcn
-------------------------------------------------------IWGLHWRKQKRQQQREFETSIRASEERLKLALWASGDGMWDWNIK
ENKVYRT-NM--DASVSHWS---SN--LLHENMHPEDREKKYELAEHLQGRTPFFEIEYRIEGAFGKWIWILDRGKVVETAHMQPMRMTGTNRNITSRKL
IENELVLSSQVLNSMNEAVVVAGLDYKIRSVNPAFSAITGYSERQITDKYLVHLAYK-QQRELFNSIEQQLLRHKHWVGEIWIRNKQRKAILVWLEINQV
IDIKGETSHFVAVFTDITERKKAEQDLRFLASFDTLTGLPNRTLFQDRLNHAITQAHRANNIVALLFLDLDRFKHINDSMGHHVGDLLLKAAAKRLQNAV
REGDTVARLGGDEFTIILEGVAKKAATLISEKVLRAFQTPFLLEDKSLTISTSIGISLYPNDADNADSLIKFADTAMYHAKSLGRNNFQFYTHKLNEIAT
RHVLLEAGLKQAIHRNELSLVYQPKFSLRDGSLTGLEALLRWHHTELGPISPVEFIPLAEETGIINQIGHWVINHACQQLAEWNALGFNNISMAVNLSAR
QLKA-DIISTIEVALAVSGLPAQSLELELTESMIMGNPQDSVSILSKLKALGLTIAIDDFGTGYSSLSYLKRFPIDTLKIDREFVRDITNDPDDAAITSA
IIALAHSLELNVVAEGVETQAQLNFLGLQGCDEVQGFLLSKPLSAKDCLTLL--------
>tr|A1SAU4|A1SAU4_SHEAM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) GN=Sama_32
-------------------------------------------------------GWFWRERRVKRRQRREFETSIRTSEERLKLALWASGDGMWDWDIP
SGQVFRT-RM--HPHTEQQL---NP--VLLDRIHPEDKPRLHAIEQHIDGSRAFYEAEYRIENKPGHWIWITDRGKVVERKQGKPVRMVGTHKDITSRKN
AENELRLSAQVLASMNEAVVVGGLDYRIASVNPAFSLITGFNPEQVQGKHFLFLTHDRKQRHIYEAIEQQLLRNKHWAGELKIRTRDQRAILIWLEINQV
LDSKAEASHFVAVFTDITDRKKAEEDLRLLASYDPLTNLPNRTLFQDRLDHALAQAHRTGNMVALLFLDLDRFKHINDSMGHHIGDLLLKAVAHRLQNCV
REGDTVARLGGDEFTIILEGVAKKAATVIAEKLIRAFQTPFILEDQALNISPSIGISLYPMDASDSTSLVKYADTAMYHAKSLGRNNFQFYTLRLNEYAM
RHVQLEAGIKQAIVRQELSLVFQPKFRVSDGSITGFEALLRWNSKELGPISPAEFIPLAEEIGIINQLGHWVVNEACRHMAQFAAAGFDDLHVAVNLSAR
QLKA-DILSTIEVALAVAGLPAKCLELELTESMIMKSPQESVAVLQRLKALGVSLAVDDFGTGYSSLAYLKRFPLDTLKIDREFVRDISTDPDDAAITGA
IIALAHSLELNVVAEGVENEAQLEHLRKHGCDQVQGFLLGKPMAARDAMALL--------
>tr|A0KSA3|A0KSA3_SHESA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella sp. (strain ANA-3) GN=Shewana3_0429 PE=4 SV=1
-------------------------------------------------------LSLAWYRQRQVRTFMTMNQALTESDDRLRQSLRGSDSDLWEWHRD
TQSFYLD-NRGAVLGNHANEI--VT--LETLPVHPEDRDKLGQWNSMLAGEIDRFEAEYRYQRRSGNWGWLRVRGRPVSRRTHEIERVAGIYSDITLQRQ
LEDEINLLAQAFENTSEGVLILDVDENIRVANHAAQQIIGSEQHDLVGQSFSQFV---QMKDGSTEVHQLLGQDSSWTGERELVGQNGLVCPVWLNVSVM
QSASDSSVHYVIVFSDITERKRTEADLRRLANYDVLTGLPNRSLFSSRLLQSIQTAQQTGEKLALLFLDLDRFKHVNDSYGHSMGDALLVEASNRLQSCI
GSEHLLCRFGGDEFVILLRNANNNEINHIAERLLAQIVAPFKLFGREFYISTSIGISIWPDDAVQPEAFIKNADLAMYHAKEEGRGNFKYYSSERNAQAL
YHLRLEADLRKAIEREEFELYYQPQIDILGDKFIGMEALIRWRHPKEGYIRPDIFIKVAEACGLVVEIDRWVFRRACLDGAKWVKRCAAPFKLSVNISAV
HFRQPDFIEGLKKILADTQMPTSSLGLEITEGVLMKEVQAAKSHLTQLKELGIEVAIDDFGTGYSSLAYLRHFDVNTLKIDRSFLIDIATNSADQAIVSS
IIELARNLKLTVVAEGVETVEQLEQVFSRGCYIVQGYYFAKPMSVTEFERYL--------
>tr|F7RS80|F7RS80_9GAMM Sensory box protein OS=Shewanella sp. HN-41 GN=SOHN41_03238 PE=4 SV=1
-------------------------------------------------------LSLAWYRQRQVRTFMNMNQALTESDDRLRQSLRGSDSDLWEWHKD
TQRFYLD-NRGAVLGTHANEI--VP--LEELPIHPKDKNQLEQWNKMLAGEQDRFEAEYRYQRKDGSWGWLRVRGRPVARKTHEIERVAGIYSDITLQRK
LEDEVNLLAQAFENTSEGVLILDADENIRVANHAAQHIIGTEQTDLVGQSFSQFV---QMKDGSTEVAQLLGQDTSWTGERELVGQSGLLCPVWLNVSLM
HSAHENIVHYVVVFSDITERKRTEADLRRLANYDVLTGLSNRSLFSSRLLQSIQVALQTGDKLALLFLDLDRFKHVNDSYGHSMGDALLVEASNRLQSCI
GSEHLLCRFGGDEFVILLKNANSDEINHLAERLLEQIKAPFKLFGREFYISTSIGISIWPDDAVQPEAFIKNADLAMYHAKEEGRGNFKYYSSERNAQAL
YHLRLEADLRKAIEREEFELYYQPQIDILGDRFIGMEALIRWRHPKEGFIRPDIFIKVAEACGLIVEIDRWVLRQACIHGAKWVKTCAEPFKLSVNISAI
HFRQSDFIEGIKQILAETQMPTSSLGLEITEGVLMKELQVAKSHLTQLKSLGIEVAIDDFGTGYSSLAYLRHFDVNTLKIDRSFLIDIATNTADQAIVSS
IVELARNLKLNVVAEGIETVEQLEQVFSRGCYIIQGYYFAKPMSVSDFEHYL--------
>tr|A0A073KUB6|A0A073KUB6_9GAMM Sensory box protein OS=Shewanella xiamenensis GN=SXM_0402 PE=4 SV=1
-------------------------------------------------------LSLAWYRQRQVRTFMAMNQALTESDDRLRQSLRGSDSDLWEWHRD
SQCFYLD-NRGYVLGSHANEI--VT--LESLPVHPLDREKLVQWNSMLAGEVDRFEAEYRYHRRDGNWGWLRVRGRPVARKTQVIERVAGIYSDITLQRQ
LEDEVSLLAQAFENTSEGVLILDVDENIRVANHAAQHIIGSEQQSLVGLSFSQFV---QMKDGSTEVAQLLGQDSSWTGERELVGQNGLVYPVWLNVSVM
QSLNENAIHYVVVFSDITERKRTEADLRRLANYDVLTGLPNRSLFANRLMQSIQAAEQSGEKLALLFLDLDRFKHVNDSYGHSMGDALLVEASNRLQSCI
GSDHLLCRFGGDEFVILLKNVKESDINHLAEQLLAQIVAPFRLFGREFYISTSIGISIWPDDAMQPEAFIKNADLAMYHAKEEGRGNFKYYSSERNAQAL
YHLRLEADLRKAIERQEFELYYQPQIDILGDKFIGMEALIRWRHPVDGFVRPDIFIKVAEACGLVVDIDRWVLRRACSDGAKWAMQTAEPFKLSVNISAV
HFRQPDFIDGVKKILDATRMPASSLCLEITEGVLMKELQVAKAHLMQLDELGIEVAIDDFGTGYSSLAYLRNFEVNTLKIDRSFLIDIASNSADQAIVSS
IIELARNLKLTVVAEGVETVEQLEQLFSRGCYIVQGYYFAKPMSVSDFEKYL--------
>tr|A3D9G7|A3D9G7_SHEB5 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella baltica (strain OS155 / ATCC BAA-1091) GN=Sbal_3910 
-------------------------------------------------------LSLAWYRQRQINTFKQMNQALTESDDRLRQSLRGSDSDLWEWHKN
TQAFHLD-NRGAVLGTHANEI--VS--LAELPVHPQDREKLAQWDSMISGEIDRFEAEYRYQRKDGNWGWLRVRGRPVTRKSNEIERVAGIYSDITVQRQ
LEDEVNLLAKAFGNTSEGVLILDVEGSIRVANYAAQQIIGIDSADLVGQSFTQFV---QMNDGASEIKQLLSDSQSWTGERELINASQQPCPVWLNVSVM
QSANGKVTHYVVVFSDITERKRTEADLRRLANYDVLTGLPNRSLFSSRLLQSIQAAQQTGEKLALLFLDLDRFKHVNDSYGHSMGDALLVEASSRLQSCI
ASEHMLCRFGGDEFVILLRNANSDDINHIAERLLEQIVAPFKLYGREFYISTSIGISIWPDYAVQPEAFIKNADLAMYHAKEEGRGNFQYYSSERNAQAL
YHLRLEADLRKAIERQEFELYYQPQIDILNDKLIGMEALIRWKHPLDGFIRPDIFIKVAEACGLIVDIDRWVLRQACVQGAHWAKRYGATFKLSVNISAV
HFRQPDFIEDIQRILHETQMPTASLGLEITEGVLMKELHVAKDHLSRLKSLGIEVAIDDFGTGYSSLAYLRHFEVNTLKIDRSFLIDIATNKADQAIVSS
IIELARNLKLNVVAEGIETVEQLEQVFSRGCYIIQGYYFAKPMCVADFERYL--------
>tr|E6XQ03|E6XQ03_SHEP2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella putrefaciens (strain 200) GN=Sput200_3552 PE=4 SV=1
-------------------------------------------------------LSFAWYRQRQVNSFMLMNQALTESDDRLRQSLRGSDSDLWEWHKD
TQKFHLD-NRGSVLGKHTNEI--IS--LEDLPIHPLDRDKLAQWNSMLVGEVDRFEAEYRYQHREGHWGWLRVRGRPISRKTQEIERAAGIYSDITVQRL
LEDEVKLLAQAFENTSEGVLILESNENIRVANHAAQQIIGSGDTDLVGLSFSQFL---RMNDGSYEIKQLLDTETSWTGERELVNQRGHLCPVWLNVSMM
QTANIKEHYYVVVFSDITERKRTEADLRRLANYDVLTGLPNRSLFSNRLLQSIQVAQQTGEKLALLFLDLDRFKHVNDSYGHSMGDALLVEASNRLQSCI
SSEHLLCRFGGDEFVILLRNASNDEINHIAERLLAQIVAPFKLFGREFYISTSIGISIWPDDAIQPEAFIKNADLAMYHAKEEGRGNFKYYSSERNAQAL
YHLRLEADLRKAIEREEFELYYQPQIDIVGDKFIGMEALIRWRHPQEGFIRPDIFIKVAESCGLIVDIDRWVLRQACLHGAKWIKAYSEPFKLSVNISAV
HFRQADFIEGIQQILLETQMPPSSLGLEITEGVLMKELQVAKSHLNQLKSLGIEVAIDDFGTGYSSLAYLRHFDVNTLKIDRSFLIDIATNTADQAIVSS
IIELARNLKLNVVAEGIETVEQLEQVFSRGCYVIQGYYFAKPMSVRDFELYI--------
>tr|A8FQC4|A8FQC4_SHESH Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Shewanella sediminis (strain HAW-EB3) GN=Ssed_0434 PE=4
-------------------------------------------------------IGVIVYRQRQVKAFKLVNSALVESEDRLRQSLKGSDSELWEWRHD
TQMFSLE-NRGAKRKEDRKNK--LK--LKDFPVHRDEKDKLASWNNMIEGYSDRFDVEYRYRREDKTWGWTRVRGRPVELPSGKILRVAGIYSDITAQRQ
LEDDVKLLAQAFGNTSEGVLILDASERIKVSNKAAQTIIGSDARVLTHKYFSDLM---VAKEGSDEIAHLLDQGVSWTGEREFVCTNGSSCPVWLNVSTM
LGGKGDITHYVAVFSDITERKRTEADLRRLANYDVLTGLPNRSLFSTRLAQSIHRAEHSGEKLALIFLDLDRFKHVNDSYGHSMGDALLVEAASRLQSCI
SEEHTLCRFGGDEFVLLIRDADNDKINHVCTELLVQIEAPFELFGREFFISTSIGVSLWPDDTRQPEVLIKNADQAMYHAKEEGRGNFQYFSSERNAEAL
YHLRLEGELRKAIERDEFELHYQPQVDILGDKLIGMEALLRWRHHKDGLVRTDVFIKVAESCGLIIDIDRWVLRQACVQGALWANSYKENFKLSVNISAV
HFRQPDFIDGVRSILEETKIPPSALGFEITEGVLMKELHIAKDHLRDLRELGIDVAIDDFGTGYSSLAYLRHFDVDTLKIDRSFLIDIATNETDQAIASS
IIELARNLKLNVVAEGVETKDQLEQVFSRGCYVIQGYYFSKPLTVSDMESYM--------
>tr|B1KNC6|B1KNC6_SHEWM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella woodyi (strain ATCC 51908 / MS32) GN=Swoo_0322 PE=4 
-------------------------------------------------------IIILIGRQRQISAFRVVNEALVESEDRLRQSLKGSDSELWEWRYD
TQMFNLE-NQGAALT-GSKNI--LT--LDDFPVHRDEKKGLESWESMLNGDSDRFEVEYRYRREDKSWGWTRVRGRPVDFPTGRITRVAGIYSDITTQRQ
LEDDVKLLAQAFENTSEGVLILDAKERIKVSNKAAQIILGLDVEAFHSKTFSSLM---VAKEGLDEVAKLLGRGDSWTGEREFICANGNNCPVWLNISTM
LGGKGDIVHYVAVFSDITERKRSEAELRRLANYDVLTGLPNRSLFSTRLAQSIHRAEHSGEKLALIFLDLDRFKHVNDSFGHSMGDALLVEAASRLQSCI
HDGHTLCRFGGDEFVILLRDVSDDMINHICTELLKQIETPFELYGREFFISTSIGVSLWPDDATQAENLIKNADQAMYHAKEEGKGNFQYYSSERNSEAL
YHLHLEAELRRAIERDEFELHYQPQVDILDDKLIGMEALLRWRHHQDGLIRTDIFIKVAESCGLIIDIDRWVLRQACIQGAQWASVYGESFKLSVNISAV
HFRQPDFIEGVKAIIHETQIPAKILNFEITEGVLMKELNIAKAHLKELKCLGIDVAIDDFGTGYSSLAYLRHFDVTTLKIDRSFLIDIATNEADQAIASS
IIELARNLKLSVVAEGVETKAQLEQVFSRGCYIIQGYYFSKPLTQPEMERYM--------
>tr|D4ZEK8|D4ZEK8_SHEVD Sensory box protein OS=Shewanella violacea (strain JCM 10179 / CIP 106290 / LMG 19151 / DSS12) GN=SVI_0267 PE=4 SV=1
-------------------------------------------------------IGVILYRQRQVQAFKRINTALVESEERLRQSLKGSDSELWEWRHD
SQMFSLE-NQREEKEDDRGNI--FK--LEDVPIHREDRDKVNAWDNMQQGLSDRFDVEYRYRRKDKSWGWTRVLGRPVEVASGSILRVAGIYSDITLQRQ
LEDDVKLLAQAFGNTSEGVLILDGAERIKVSNKAAQTIVGASAEMLNGKFFSELI---LAKEGSDDIVCLLKQEISWTGEQEFLREQGGSCPVWLNVSAM
LGSKGNITHYVAVFSDITERKRSEADLRRLANYDVLTGLPNRSLFATRLTQSIDGAEHSGEKLALIFLDLDRFKHVNDSYGHSMGDALLVEAANRLQSCI
SPEHTLCRFGGDEFVILLRDAANDTINHICTQLLEQIETPFELYGREFFISTSIGVSLWPDDAREAEVLINNADQAMYHAKEEGRGNFQYFSSERNSEAL
YHLRLEAELRKAIERDEFELHYQPQVNILGDKLCGMEALLRWHHHEDGLIRTDIFIKVAESCGLIVDIDLWVLRQACIQGKIWSKSYAEPFKLSVNISAV
HFRQPDFIQGVKRILQETELDPRLLGFEITEGVLMKELDTAKEHLLELRALGIDVAIDDFGTGYSSLAYLRHFDVDTLKIDRSFLIDIATNEADQAIASS
IIELARNLKLNVVAEGVETKEQLEQVFSRGCYVIQGYYFSKPLTVVEIEKYM--------
>tr|A0A0C3R2Y1|A0A0C3R2Y1_9GAMM Contig_26, whole genome shotgun sequence OS=Shewanella sp. cp20 GN=DB48_08400 PE=4 SV=1
-------------------------------------------------------LYFLLLRQKQIGAFRRVNKALKESEDRLRQSLRGSDSELWEWHSE
SETFLLE-NRGRYFPDKGDAF--EK--MDEFPIYADDQDKFTAWKRLLSKQDDRLDVDYRYRRPDESWGWTRVRGRALEFPSGRVKKVAGIYTDITTQRR
LEDDVKLLAQAFANTSEGVLILDADERVRVSNKAAQSILGMSADELIDRYFSQLV---HSSEDSDEISILLEQGITWTGEHEFQCSEGLICPVWLNLSTM
KDDRGAISHYVAVFSDITERKQTEADLRRLANYDVLTGLPNRSLFASRLAKCIHRAEQTQDKLALIFLDLDRFKNVNDSYGHSMGDALLVEAASRLQSCV
SESHTLCRFGGDEFVILMRDMVDDEVNHLCEALIRQIEKPFELYGREFFISTSIGVSLWPDDAKQPEVLIKNADQAMYHAKEEGRGNFQYFSAERNAEAL
YHLKLEAELRKAMDRQEFELYFQPQIDILDDKVVGMEALLRWHHPKEGYIRPDIFIRVAESCGLIIDIDRWVIKQACIQGAKWAAHFGDELKLSVNVSAV
HFRQPDFIQDVQQALKESGMPAKMLGLEITEGVLMKELHVAKDHLKALREIGIEVAIDDFGTGYSSLAYLRSFDVSTLKIDRSFLIDIANNEADQAIASS
IIELARNLKLKVVAEGVETQEQLEQVFSRGCYVIQGYYFAKPMTIDEFEKYL--------
>tr|A1S2I3|A1S2I3_SHEAM Sensory box protein OS=Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) GN=Sama_0378 PE=4 SV=1
-------------------------------------------------------LAIILIRHRQVERFRHMNTALLESEDRLRQSLRGSDSDLWMWTRK
DNAFYMD-NRNGVLSVEQQVL--KN--FEEFPIHPDDRDRVSHWLAVINGEIERFEAEYRFQRRTGTWGWLRVRGRPSQLKTGEVEKISGIYSDITQHKL
LQNEVDLLAQAFENTSEGVLILDADEQIKVANRAAQSILGAGMAELAGRKFIALL---TEHGTRSEIATLLANGMSWTGERELRIGSGQVCPVWLNVSVM
LGLQGKVQHYVVVFSDITERKRSEADLRRLANYDVLTGLPNRSLFAARLNQAIHKATQNEEKLALMFLDLDRFKHVNDSFGHGMGDALLVEAAARLQSCI
DPEYTLCRFGGDEFVVLIHG-AEDTLNHLANTILGQIETPFKLFGREFYISTSIGISIWPDDARQPEALIKNADLAMYHAKEEGRGNFQYYSQERNAEAL
YHLRLEADLRKALERQEFCLHYQPQVDVNDNQVIGMEALLRWQHPKDGYIRTDIFIKVAEACGLVIDIDKWVLRQACLDGARWSRKLKRPFKISVNISAV
HFRQPDFIDHLRRTLEETCIPVENLALEITEGVLMKELHIARDHLRLLREMGVQVAIDDFGTGYSSLAYLRHFDVNLLKIDRSFLIDIADNQADQAIVSS
IIELARNLKLKVVAEGVETREQLNQVLSRGCHVIQGYYFAKPMARDDMDAYL--------
>tr|B8CTY4|B8CTY4_SHEPW Sensory box protein OS=Shewanella piezotolerans (strain WP3 / JCM 13877) GN=swp_4747 PE=4 SV=1
-------------------------------------------------------LAVILIRQRQVMAFRAINSALSDSENRLKQALKGSDSELWEWLLE
TDVFRLE-NVGGLLSAKDSQV--YK--IGEIPIHNEDKSNLIAWKDMLEERVDRFEVEYRYLRSDNSWGWIRVLGRPVERRNGEIERVAGIYTDITEQRQ
LKDDVYLLAQAFENTTEAVLIYDRDELIQVTNKAAQDILGYKSSTLIGQSFSEVL---LGKESGTHIADLLQHGLSWTGECTVACANDKQCVVWLNVSSI
LNTNGEATHYVVVFSDITDRKRTEADLRRLANYDVLTGLPNRSLFSSKLSQSIYQAEKEGGKLALLFLDLDRFKHVNDSYGHSMGDALLVEASNRLQTFI
SQENVLCRFGGDEFVILLRDDIYDSINRLCEQLLASIQQPFDLYGREFYISTSIGVSLWPEDAKQPETLIKNADLAMYHAKDEGKGNFKYYSQDRNAEAL
YHLRLEADLRKAIERDEFELHFQPQIDILNDKLVGVEALLRWNHPQDGYVRTDIFIKVAEACGLIVEIDRWVMREACRHGARWAQTLTEPLEVSVNISAL
HFRQHDFIQGVEKCLAETGMPNHALSLEITEGVLMKELKVAKQHLKELKALGVDVAIDDFGTGYSSLAYLRHFEVNTLKIDRSFLIDIATNKADQAIASS
IIELARNLKLDVVAEGVETHEQLEQVFSRGCYVIQGYYFAKPMSSADLEVYM--------
>tr|A8GZL3|A8GZL3_SHEPA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella pealeana (strain ATCC 700345 / ANG-SQ1) GN=Spea_0422
-------------------------------------------------------LGIIFYRQRQVMAFKGVNSALIDSENRLKQALKGSNSELWEWQRE
SDLFRLE-NTGGVLAAGQSQV--YR--LDQFPIHKEDVGEMAAWEDMLQERTDRFEVEYRYWRTNGTMGWVRVSGRPVERDSGSIERIAGIYSDITEQRK
LKDDVYLLAQAFENTSEAVLIFDSDETIQVSNKAAQNIIGLDSESLIGLSFSQVL---QGEEKSASIANLLQQGLSWAGECFVDAGGCQRCAVWLNVSSI
LNSSGNASRYVVVFSDITERKRTEAELRRLANFDILTGLPNRSLFSSKLAQSVYQAEKEGGNLALLFLDLDRFKHVNDSYGHSMGDALLVEASNRLQSLV
ADENVLCRFGGDEFVILLRDTPTDTVNYLCEQLLASIEKPFVLYGREFFISTSIGVSLWPEDAKQPEVLIKNADLAMYHAKEEGKGHFKYYSEERNAEAL
YHLALEADLRKAIERNELELHFQPQIDILNDKLVGVEALLRWNHPKEGFIRTDIFIKVAEACGLIVEIDRWVMGEACRRGAIWSQKLAEPIKVSVNISAL
HFRLPDFISGVQQIMAETEMPHSALSLEITEGVLMKELEVAKQHLKALKELGIDVAIDDFGTGYSSLAYLRHFEVNTLKIDRSFLIDIATNKADQAIASS
IIELARNLKLDVVAEGVETHEQLEHVFSRGCYVIQGYYFAKPMPLAEIETYM--------
>tr|B0TR82|B0TR82_SHEHH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella halifaxensis (strain HAW-EB4) GN=Shal_0479 PE=4 SV=1
-------------------------------------------------------LGGALIRQRQVKAFREINLALTDSENRLKQALKGSNSERWEWQLG
SNLFCLE-NIAGLFSDGEPQV--YK--LEQFPIHRDDASEMAAWQDMLLERTDRFEVEYRYCRADNTWGWVRVMGRPVERHTGVIERVAGIYSDISEQRK
LKDDVYLLAQAFENTSEAVLIFDSAERVQVTNKAAKNMMGLDSKRLIGLQFSQVL---QGGEKNSSIVNLLDQGLSWAGECFINAEDSLRCAVWLNVSSI
LNTNGDTTHYVVVFSDITERKRTEADLRRLANYDVLTGLPNRSLFSSKLSQSVYQAERDGGNLALLFLDLDRFKHVNDSYGHSMGDALLVEASNRLQALI
SDEHVLCRFGGDEFVILLRNNPDDVINHLCDALLASIELPFELYGREFYISTSIGVSLWPEDAKQPESLIKNADLAMYHAKEEGKGNFKYYSEERNAEAL
YHLRLEAELRKAIERNELELHFQPQIDILNDKLVGVEALLRWNHPKEGLVRTDIFIKVAEACGLIVEIDRWVMREACIYGARWAALLPEPLKVSVNISAL
HFRQPDFIKGVQQVFAETSMPNTALSFEITEGVLMKELKVAKQHIQELKSLGVNVAIDDFGTGYSSLAYLRHFEVNTLKIDRSFLIDIATNKADQAIASS
IIELARNLKLDVVAEGVETHEQLEQVFSRGCYVIQGYYFAKPMPAAEIESYM--------
>tr|Q12IS0|Q12IS0_SHEDO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15
-------------------------------------------------------ISMLWYRHRQVERFKKINQALVDSDDRLRQALRGSDSDLWEWRSD
TQMIYLD-NNAGLLGD-ADFV--HP--LSELPVHENDRDRRGEWIALLEDKGELFESEYRYYRPDGSCGWLRVRGRAVDYPTGAIARVAGIYSDISVQRE
LESEINLLAQAFENTTEGMLILDANETVIISNLAANLIFTTKPNELIGLSLSELV---RKSEINLSVDGLLGNGTSWNGERELLRRDKRTFPAWINISMM
KAENSLIKHYVLVFSDISERKQNELNLRYLANNDVLTGLANRAMFTRRLTQIISFATLNDEKLALLFLDLDRFKHVNDSYGHSMGDALLVEAARRLQSCL
TENHLVCRFGGDEFVILLRDAGDDGINHVADSLLKTIEQPFKLEGREFFISTSIGISVWPDDSIDPETLIKNADLAMYHAKEEGRGNFQYYSSERNAEAL
YHLRLEADLRKAIERDEFTLNYQPQVDILQDRVVGVEALIRWHHPEDGLIRPDIFIKVAESCGLIVDIDRWVFKQACQDAARWHTEFEQSYKLSVNVSAV
SFRQADFIDGLKDILTETGMPASLLTVEITEGVLMKELHVAKAHLRKLKALGVKVSIDDFGTGYSSLAYLRHFEVNSLKIDRSFLIDIGVNKADQAIVSS
IVELARNLKLEVVAEGVESHEQLEQVFSRGCYLIQGYYFAKPMARNELEIYL--------
>tr|Q07WL3|Q07WL3_SHEFN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella frigidimarina (strain NCIMB 400) GN=Sfri_3774 PE=4 S
-------------------------------------------------------AIILLYRQRQIHRFKQMNHALVESDERLRQSLKGSDSDLWEWHAS
TQVLSLD-NRGGVLGP-DTHI--NK--LEDIPIHQDDVERTSVWQDLVNGKVEMIDAEYRYRNQDHQWHWLRIKGRAIEVINGRLIYAAGMYTDITQQRT
LESEANLLAQAFENTSEGMLILDMKKNIKISNAAANLILAAKKSDLAGKPFSDLV---FETVEPFDMEEVFDKERFWTGECEFNCSDGSRCPVWVNVSTM
FNMNGSALHYVVVFSDITERKHNELHLRRLANNDMLTGLANRAMFSRRLGQVIETAKQQKETLALLFLDLDRFKHVNDSYGHSMGDALLVEAASRLQSCL
SEEHLLCRFGGDEFVILLRDAKDDTINHIAKQLLKQIETPFKLYGREFFISTSIGISIWSDDDQTPETLIKNADLAMYHAKEEGRGHFQYYSAERNAEAL
YHLRIEADLHRAILCNEFELYYQPQIDVDQNSIVGVEALIRWKHPKDGMVNPDVFIGIAESCGLIVEIDRWVLTQACLDGADWHQRYQSEITVSVNVSAM
HFRQPDFIDFLTATLHQTGMPARCLSVEITEGVLMKEIDIASQHLRALEQLGIDVAIDDFGTGYSSLAYLRSFQVNILKIDRSFLIHIDTHQADQAIVSS
IIELARNLSLEVVAEGVETSEQLAQVVQRGCHIIQGYYFAKPMPKAELELDI--------
>tr|A0A094JAB8|A0A094JAB8_9GAMM Uncharacterized protein OS=Shewanella sp. YQH10 GN=HR45_17560 PE=4 SV=1
-------------------------------------------------------ISIIIYRHHQVKRFQTINSALVFSDERLRQALRGSESDLWEWHHE
DDCLYMQ-NHGNVLHSELPEL--VK--VPDLPLHPDDRSQEEQWFRMLKGEQEFFDCEYRYRTAEGTWGWLKVRGRPVNVNTGEVLKVAGIYSDITETRV
LENEVTLLARAFENTTEGVLILDALERVEVSNQAAESLLGLSDSQISGMPVSEVI---FRHDGKATVIELLDGSDTWTGERDFITHDQQHLPVWLNVSII
KNERQQLQYFVLVFSDISERKQSEAELRKLANFDVLTGLPNRSLFANRLEKAMMRADDQQQKLALLFLDLDRFKQVNDSYGHSMGDALLVEAANRLQSVL
RKDEILCRFGGDEFVVLVN-SGDDYINRICEAMLEQISSPFKLFGREFFISTSIGISIWPDDTRQSETLIKNADQAMYHAKDEGRGNFQYYSRERNAEAL
YHLRLEGDLRKAIEHNQFELHYQGQFDLLDDRMTGVEALLRWKHPHDGYVRPDIFIKVAESCGLIVDIDRWVLQQACVDGACWSQA-DDSFRMSVNISAV
HFRQPDFIDTLSQILKQTGMPAEQLTLEITEGVLMKELHVARQHLQQLRSMGIEVAIDDFGTGYSSLAYLRHFEVNTLKVDRSFLIDIASNSADQAIVSS
IIELARNLKLKVVAEGVETREQLEQVFSRGCYVIQGYYFCKPMPAAALMAWL--------
>tr|E1SN88|E1SN88_FERBD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Ferrimonas balearica (strain DSM 9799 / CCM 4581 / PAT) GN=Fbal
-------------------------------------------------------MLGLLQRQRQVRRIRQFNTELSQSQQRLHLALSAGRSDTWEWDKA
SNRFRLE-NHQRCLGEDDEPR--LE--MNQMTIHPDDRLRWRAWREHYLGLSEHYDVEYRQADLQGRWRWIWAAGKAVERENGQARRVVGIYSDMTAHRR
LEEEHGLYAQAIENTAEGVVILDHQLMVQGCNPAAEMILATPRARLMGDRFHHYW---YREQG--QLDAVTRGNASWQGEVLLRGSAGETVPVWLNISPM
G---DNARHLVALFSDITERKRAELELRRLADFDPLTGLPNRSQFNTRLHAAVQARGPGGRPMALMFLDLDRFKHINDTYGHSTGDGLLVQAAQRLKGLM
GDSELLCRFGGDEFIVLISEFRTAELERLAQRVLSAIAEPFELDGQLFYVSTSVGIACFPDDAQQPETLIRHADLAMYHAKEEGRGRYSFYTPQRDAQAT
YQLELENALRQALEANQLELHYQPQVDLQTGQVTGVEALLRWFDEENGAVPPDTFITLAESSGIIVKLDRWALRQACQSFVRWG--LGDGIKLSVNVSAS
HFHQPDYVDFVSRVLTETGLPASQLCLEITEGVLMKRVSLAQSHLHALRRLGVSVAVDDFGTGYSSLAYLSQFAVDSLKIDRSFVHDLPGNLTNGAITRS
ILDMGRNLGLQVVAEGVETEEQEAFLRHQGCARMQGFRYARPMNAEACCLWL--------
>tr|K2J879|K2J879_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Gallaecimonas xiamenensis 3-C-1 GN=B3C1_12319 PE=4 SV=1
-------------------------------------------------------LLFAQQRRRQQQRLHKAFKLAKDSEQQLRLAMFGANANTWSWLAE
SNSFDIH-RPESEFASADGNV--HA--MDKVPIHPDDRDRFAAWNQHLAGQSSRYDVEYRVMVN-NQIRWMHVIGRIVDVEQGRAQRISGIYQDITERKH
LEGEVNLYARAFENTAEGVLILGAGREILSGNPAVERICGYDRDQLIGHPLTFLL---PGEFLDGDLWQQVYRSGAWTGETTLIRQDGSSCALWLNVTVM
DDKASASRHFVVVFSDMTERKAAESELRRLANYDVLTGLPNRAMFMQRLGQALATARSHDQRLALLFMDLDRFKTVNDTYGHRVGDGLLIEAANRLQEVV
GDRDTVARLGGDEFVVIIHEVESEQLIPLCEALLSTLAEPFSVYGRQFFLSTSIGISLYPDDGREPEALLRNADMAMYHAKDEGRNNMQFYCHRRNQEAM
QLMQLEADLRLGLEREEFFVVYQPQVDVLGEIVVALEALARWRHPTQGQVSPDVFIKVAENTGLIAALDGLVLRQAVAAISELNKERRKPLTLSVNISAA
HFRQHDFVAQVRQVLDDTGLKPALLCLEITESTLMREVGTAKEHLSALRKLGVSVAVDDFGTGYSSLAYLKQFEVNELKVDKSFVSDLTDSEADAAIVRS
VVDLARNLGLKVVAEGVETEEQLDLCLALGCYRVQGFYYARPMALPDLKSWL--------
>tr|F7RTA1|F7RTA1_9GAMM Sensory box protein OS=Shewanella sp. HN-41 GN=SOHN41_03597 PE=4 SV=1
-------------------------------------------------------VWSILWRKRKRQRQREFETSIRASEERLKLALWASGDGMWDWNIK
ENRVYRT-NM--DTSIPQWS---SH--LLHESIHPEDREKKHELAEHLQGRTPFFEVEYRIERSPSNWVWILERGKVVESSNHQAIRMTGTSRNITSRKL
IENELILSSQVLNSMNEAVVVASLDYRIRSVNPAFCAITGYTERQICDKYLVHLAYSRQQRGLFSSIEQQLLRHKHWAGEIWIRNKGRKALLVWLEINQV
IDIKGETSHFVAVFTDITERKKAEEDLRFLASFDTLTGLPNRTLFQDRLNHAISQAHRSNNIVALLFLDLDRFKHINDSMGHHIGDLLLKAVARRLQNAV
REGDTVARLGGDEFTIILEGVAKKAATLISEKVLRAFQIPFLLDDKSLTISTSIGISLYPNDADNADSLIKFADTAMYHAKSLGRNNFQFYTHELNEMAT
RHVQLEAGLKQAIARNELSLVYQPKFSLRDGSLTGLEALLRWHHSELGPISPVEFIPLAEETGIINQIGLWVINHACQQLAQWNELGFKDFSMAINLSAR
QLKA-DIISTIEVALAVSGLPAKSLELELTESMIMGNPQESVTILAKLKALGLTIAVDDFGTGYSSLSYLKRFPIDTLKIDREFVRDITNDPDDAAITSA
IIALAHSLELNVVAEGVETQEQLNFLALQGCDQVQGFLLSKPLSAKDCLILL--------
>tr|A0A021W2V0|A0A021W2V0_9GAMM Sensor protein OS=Lysobacter capsici AZ78 GN=AZ78_14270 PE=4 SV=1
-------------------------------------------------------LSFGWRWHVARQRERGYFTQIREREERLKLALWASGEQFWDYDLQ
RRELHRM-RVDDHNPQSPDIGVQAI--ADDHEIHPDDLSRTELLRKHLKGDAALFLSEHRMRTPKGEWGWVRARGRVVERAEGHPVRVAGTGRDVTAIRS
AERERRISSEVLRSMAEAVAVFDRDFVFVSINPAFSRMTGYPENEVIGQTTGLLDSRQHDPEFYSDMRAELQRSGRWSGEIWQQRKDGNEFLCWLQASIV
LDSSGQRGHYVAVLTDITDQKRAEQELRYLANYDTLTSLPNRTLLSERLSRAIVRARRHGHRIALLFLDLDRFKDINDSLGHAAGDRILRAAAVRLQETV
GAEHTVARLGGDEFTVVLENLDTEQAEDVARRLIKAFEAPLDFDEHDVAISPSIGISVYPDHAQVPTDLLKHADTAMYQAKAAGRRTFMRYTEAMDVEIR
QRATISAALRKVLDRGELRLVYQPRLSLPEARINGVEALLRWNSPEHGNIPPSEFIPLAEESGLILEIGEWAMREACNRLRQWRQQGLDQLSVSVNVSAI
QLLRGDLPKMVARALSESGIPPWRLELELTESVVMSNAAHTSNTMQALRELGVALAVDDFGTGYSSLAYLKRLPINTLKIDKEFISDLTRDPDDEAITST
VITMAHSLGLNVVAEGVELEEQMEFLRAHGCDEIQGYWLARPLEADVCLKFI--------
>tr|U1M0L9|U1M0L9_9GAMM Diguanylate cyclase/phosphodiesterase OS=Pseudoalteromonas spongiae UST010723-006 GN=PSPO_19806 PE=4 SV=1
-------------------------------------------------------TFIYIKRVKQQHRLQQLHDESMAAKQRARLALEASNSGVWVYNSH
NQQLDQE-RIVSDLGYERE-MTTLH--DHMSLIHPEDRIREAKWRAFSSGETNLWDVTYRMRAKSGEWVWYRDLGKRSKEKNEENPVYAGTYTNISETKN
KEIQARLYGEALRKMNEWLIILDSKFKLVVSNEAFNKRFSTHSE-ATQDTL-LALFDEQRQAFYIEQLARLRVGEHLRREETWVFD-NETIDVLLSISAI
GDES--VSNYVVVVSDLTQQKAAEKKLTQMANFDHLTQLANRSLINDRIEQALLHAQ--NKVIAVLFIDLDRFKQVNDSLGHSIGDRLLVEAAKRMTAVV
GEQHSVGRQSGDEFIVLFDDVVSQEISQYANELNSQLAKPYKIGGNTVNISSSIGISFYPFDAETTEELIQKADIAMIHAKNSGRNCYRFYTEQLNKEAR
NRMLLENELVNAVQNRQLTNFYQPIVNTQSQKVVGVELLLRWFKD-GDMISPGVFIPLAEQIGQIVAITEIALETATTELASWLASNA-NRYLSINLSAL
HITQPNLVERFVTILADNNVSPRQIRLEITEGILIEDTVNALEQLERLQKAGFKLYLDDFGTGYSSLTYINQFPIDVIKIDQSFIRQMLSSRTNQAIVQT
IADLAKNLGSYCIAEGVEELTQVTVLKRLGCYNLQGFYFAKPVPATTFLSEE--------
>tr|A0A0A7EJL5|A0A0A7EJL5_9GAMM Uncharacterized protein OS=Pseudoalteromonas sp. OCN003 GN=OM33_17470 PE=4 SV=1
-------------------------------------------------------AGVYSRRVKQQHILQKLHDDSLAAKERARLALEASNSGVWVYNTQ
NNHLYQE-RITSDLGYGSE-VSSLH--DHMMLIHPEDRKRDAEWRLFSTGKTKLWDVSYRMRAKSGDWVWYRDMGKRSKENSDGSPVYTGTYTNINETKN
KAMEARLYGEALRKMNEWLIILDSQFQLVASNEAFNKRFSQNGQ-ANQATL-LALFDENKQAEYREQLAKLKPGQHLRREEVWVFD-DERIDVLLSISTI
GDES--ITNYVVVVTDLTQQKQVEQKLTQMANFDHLTQLANRSLINDRIEQAVLHAK--NKVVAVLFIDLDRFKQVNDSLGHSIGDRLLVQVANRMTKVV
GEQHSVGRQSGDEFIILFEDVVSEEVSQYANELNKQLEKPYTIDGNTINISSSIGISFYPFDAESTEELIQNADIAMIHAKNSGRNCYRFYTDQLNKEAR
NRVLLENDLVNAVKQNKLTNFYQPIINTQSQKTVGVELLLRWFNN-EEMISPGVFIPLAEQIGQIVRITELALEKATLELKDWLLIDS-NRYLSINLSAL
HIGQPNLVKSFLDILASTGVSPNQIRLEITEGILIDDTANALEQLQRLKDAGFKLYLDDFGTGYSSLTYINQFPIDVIKIDQSFIRQMLSSKTNQAIVQT
IAVLAKNLGTYCIAEGVEELTQVTVLKRLGCHNLQGFYFAKPVPANIFLSED--------
>tr|G4QGM4|G4QGM4_GLANF Diguanylate cyclase/phosphodiesterase OS=Glaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064) GN=GNIT_1543 PE=4 
-------------------------------------------------------LWFIVRRNRVQASLADANKQILLYNNRLTSALKASNSDIWEWSSE
TKRINTP-RLRNELGYNKND-TEFE--DHLSLIHEVDRLQLSAWRQFIRGEEELFDNTYRMKHANGDYLWFRDAGSISSA-ENEVITVTGTYTNVTENIA
SKERLKLFGDAFKHTRDWVLIFDREKQPLGANPSFYKAFGISENVDFQSQLKYDNQEGIKQRFILK-LAGLKPGEHWKTELEFVVA-GTKMTTLTDVNAI
ADENRLIEYYLVILTDITEQKEAQESLLKMANYDVLTGLINRSLLIEKLKQSISYARRHGTSLSVIFIDLDRFKPINDTFGHQAGDKVIVEIAQRIKHKL
RDNDIVARLGGDEFVVVLEETQEESVNNVVQELLILLEQPIYIGSHSVSVSGSAGIAMYPDDAIDAESLLRNADVAMYSAKELGKNGFQHFTATMNEKVQ
LDMLLQNKLKVAVARNEFENYYQPIIDVKNKKTVGFEMLMRWHSD-NEAISPCVFIPIAEHLGLIVEMTIKAIERGLNDVAKWYEQGF-RGYMAINLSAK
QFSTRPDFEKILQLLNDYGLPASCLRFEITEGLLIDNNDKTIDYMHEMRALGFKISLDDFGTGYSSLRYLKDFPIDVLKIDKSFVDHIGVDKGTESIIES
TLIMTKMLSMDTVAEGIETQLQVDFFNKTNCRFLQGFYFSKPVNHQKCYELL--------
>tr|Q088N8|Q088N8_SHEFN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella frigidimarina (strain NCIMB 400) GN=Sfri_0415 PE=4 S
-------------------------------------------------------IWFFYARQKKVAKQREFDNSIRASEERLKLALWASGDGMWDWNIK
DDKVYRT-NM--VEPMSFSL---KQ--LLIKNIDPEDRPRQKLLNDHLNGESEFFEAEYRVETKPGQWAWVLDRGQIVERSNNIPVRMAGTHKDITSRKI
TENELKLSSQVLFSMNEAVVVGELDYQIRSINPAFSRITGFKHRDVVGKHFLFLTMGKQSREFYNSVETQLLRHKHWAGEIHIRTRNRRGILAWLEINQV
IDNKGETSHFVAVFTDITARKKAEEDLRVLANFDPLTGLPNRTLFQDRLNQAVTKAHRANSIVALLFLDLDRFKHINDSMGHHIGDLLLKAVAHRLQNAV
RDGDTVARLGGDEFTIILEGVAKKAATIIAEKVLHAFQTPFLLDDKILTISPSIGISLYPEDADDTTSLIKYADTAMYHAKSLGRNNFQFYTEQLNQYAT
RHVQLEAGLKKAIQDNELYLVYQPKYDVKTEKIIGLEALMRWESPELGFISPVEFIPLAEETGIINQIGHWAIQQACNQLAQWHQQGFEHISIAVNLSAR
QLKA-DIISTIEVALAVSGLPASALELELTESMIMGNPQDSVTVLSQLKALGLTIAIDDFGTGYSSLSYLKRFPIDTLKIDREFVRDITEDPDDAAITSA
IITLAHSLELNVVAEGVETQAQLNFLREGGCDQVQGFLLSKPLSAVDCLALL--------
>tr|A0A034TVL4|A0A034TVL4_9VIBR Diguanylate cyclase/phosphodiesterase OS=Vibrio sp. JCM 18905 GN=JCM18905_3018 PE=4 SV=1
---------------------------------------------------------------------TRHQTTATTPLPTLQEFIDCLEDHIWIKGMD
GLYSMTNRSVENAWQKTNSEIIGKD---DFALFSHERAEKFIEADNLVVATGTNIVEECRQIDENNNPTWLETIKSPVRDNDGNLIGILGMTRNITRRKM
VETQLSLASKIFNNSQEGMVITDRNANIIDVNTAFTQITGYRSEEVIGKNPRILRSGHHDQGFYKQLWHQLETKGQWKGEFINRKKDGSIYPQLATISAV
MDDKNHLINYICVFEDISVRKAHEEKLQRMAFYDPLTNLPNRTHLLSLLEQHIETGHKNQQTFATLFLDIDHFKHINDSMGHFCGDQLLSKLAIRLQDIL
HLNAHVARIGGDEFVIILPDVHSVALLETVGDILSVFQQPFDLANDSLRVSTSIGIALYPRDGQDSETLLKNADTAMYLAKKNGRNGYAFYSPDLTDKSV
SHVRIQSALHQAIEKQQLRLEFQPQYNLEQHAIVGVETLLRWQHPEFGLVPPADFIPIAEKTGLIQSIGEWVLLHACQQGNAWLEQGVEFGRIAVNVSAL
QLQQSNFIQRLSDILNQTGFPAQRLDLEITESFLLIDPQQAIASLNQLRGLGIEISLDDFGTGYSSLSYLKGLPINKLKIDRSFVSDVPSNSDSNAIVNA
IIAMGKTLSLKVVAEGIETQEQADYLFEKGCVYGQGYLFSQPVSAEKLFR----------
>tr|A0A099LP62|A0A099LP62_9VIBR Diguanylate cyclase OS=Vibrio navarrensis GN=EA26_01230 PE=4 SV=1
---------------------------------------------------------------------LRHQAAELTAIPKLQDFIDCLEDHTWIKSVD
GKYLATNQSVEQAWQKSGLEIVGQS---DYELFPESRAKKFIESDELVVASGNQVVEECYVFDDQQNKSWLETIKSPIRNRRGELIGILGMTRNITRRKH
IETQLTLASRIFNNSQEGMVITDHNARILDVNQAFSSITGYSAEEVVGKDPSILRSGHHDDAFYQQLWQQLEQQGQWKGEFINRRKDGSIYPQLATISAV
QDERHELVNYICVFEDISARKANEAKLERMAFYDPLTGLPNRTLLVKLLQQQIKSGEQSGLSFATLFLDIDHFKHINDSLGHLCGDTLLSQLGRRLSEAL
HGRAHISRIGGDEFVVLLPDLQNEQLTQALSDILKVFNRPFHLSEENLRVSTSIGIARFPQDGTDSASLLKNADTAMYLAKKNGRNGYAFYSPDLTNQSL
SRLRYQSALHEALEKDQLFLLYQPQFNLYESRLVGVEALLRWQHPEWGLISPAEFIPVAEKTGLIQEIGLWVLRSACQQAATWLSQGYRFSHMAVNVSAL
QLQNPHFISELQDILQDTRLPARKLELEITEGFLLHDPAKAIQALNQLRTMGVEIALDDFGTGYSSLSYLKGLPISKLKIDRSFINDIPVDSDSNAIVKA
VIAMGETLALTVIAEGVENQQQVDYLISQGCLLGQGFYLARPQDAQQVAQ----------
>tr|U3BS83|U3BS83_VIBPR Putative signaling protein OS=Vibrio proteolyticus NBRC 13287 GN=VPR01S_27_00280 PE=4 SV=1
---------------------------------------------------------------------LTHTLGQSLTLPTLQQFINSLDDHAWVKDPN
GIYIMGNLAIEQAWGRTLSEIVGAS---DHQLFSPQLARKFIASDHKVMEHGKMTVDECCDQGTRGDKQWYETIKAPIFDHQQRLVGILGMTRNATQRKQ
VENQLSIATKIFSNSHEGVVITDADGKIVEINAAFSDITGYPPQDVIGHNPRLLQSGHHDRAFYRDMWAQLKRDGRWKGEFINRRKDGSVYPQLATISAV
YDEYKQLMNYICVFEDISLYKEHEEKIEQMAYFDPLTDLPNRTHLIQLLDEQIVASRESGRSFATLVLDVDHFKHVNDSLGHFSGDKILSELATRLKAHL
RHQDHIARIGGDEFVIILSDLDSADLSLMMQRLFSSFQQTFSPHEAALRLSTSIGVAMFPCDGDDGETLLKNADTAMYQAKKNGRNGYAFYTPELTDVAV
SHVRLQSALHEALELGQFSLAYQPQYQLADAHLTGFEALIRWQHPELGAISPAQFIPIAEKSGLMQAMGKWVLTTACRQGKTWLDKGYEFGKLAVNVSAI
QLQQSEFTERLEAILHDTGFPANRLEIEITEGLLMEDQEQAIRYLDQVRQLGVEIALDDFGTGYSSLSYLKGLPLHKLKVDRSFVSDVPDDTDSNAIVNA
IIAMGHTLGLKVIAEGIENSQQQDYLLRQGCCYGQGYHLGRPMDAEAATT----------
>tr|A0A0A1H769|A0A0A1H769_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Burkholderiales bacterium GJ-E10 GN=E1O_19340 PE=4 SV=1
--------------------------------------------------------------------------------------------------MQ
ENWRR-------------------------RTAFSTT-----AYAAVVLVS-------MMLQLLSRN--F----LSQSQFIAGLVGLYLFLLSLTLQRRD
D------EEAAFE-SQEPMLVTDASGNILRVNQAFTRTTGYAADEVVGKNPRLLQSG------YAKMWERIHDSGHWQGEVWDRHKNGSVYPKWLVISSV
RGRTGQATHYVGSFSDLSERKEAAAAISRLAYFDSLTGLPNRRMLTDRLRHALVAATRNRQYGAILFLDLDNFKTVNDTVGHDEGDRLLQEAGRRLRGAI
REEDMVARFGGDEFVIVLENLGPREQKTVADKLLAELAAPYTLLGREFPSSASIGATLWRHFTGHMHDLLKRADMAMYEAKKSGRNTVRFFDPVMQAAIE
HRSRSEARLRSALAQDQFHLHFQPQVG-DDGTVRGAEALLRWNDPERGWISPDEFIPIAEETGLIIPIGRWVLQAACAQLRQWSDSHRSDLRVAVNISAK
QFDASSFVDEVREIVQASGADPRLLELELTETMLLKNVDAAIAKMAALRKLGITFALDDFGTGYSSLAYLQQLPLDVLKIDRTFVRGLGENARSEAIVRT
IIQMAHNLNLRVLAEGVETEEQRRMLADRGCNLYQGYLFGKPLPAPQFER----------
>tr|G0A3J9|G0A3J9_METMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomonas methanica (strain MC09) GN=Metme_3093 PE=4 SV=1
----------------------------------------------------------------------FV-------NEENFFLLINTTRNL----GH
GRWQINN-ACLELYGLI------------------GK-----GKTCAELAS----RHHFEVSEQNDEQAWQ---EITKTPIFGANGGRKALGQEITDRLE
N------ERQVMSNSDEAVLISDQQNNIVYVNDAFTQITGYTLDEVAGQNPRILSSG------YRDMWQKILTDGNWHGEIWDKRRNGEIYPKWLNISSV
HDSDGTLCNYVAIFSDISQRKADEAMLTFLAYHDPLTKLPNRLLLRDRFEQAVGLTHRHAGSVALLYLDLDQFKNINDTLGHEIGDRLLVAVAKRLQANV
REVDTVSRLGGDEFVIVLTDMPDHAVSLVAQNILNHLGEVFEIDQYRLTSTTSIGIALYSVDSDDFESLLKLADTAMYHAKDSGRNTYRFYTDKMNIDAM
ERLRMRNGLAEALLKQQFVLYYQPQFDLHSAELVGIEALIRWNHPEKGLILPDKFIPIAEQTGQIVPIGEWVISEACRQAKAWQQQGYAPVRVAVNLSSL
HFKRGDVIKMITGLAQEHDLDPQYIELELTEAIMLQDVDHILDIVKTFKTLHFTLSIDDFGTGYSSLAFLKRFRVDKLKIDGSFIRNLEVDTHDLAIIRS
IIQLAKGFNMRTIAEGLETQEQLEILRREGCQEGQGYFFSYPLPVKQVVK----------
>tr|G3IW26|G3IW26_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_0629 PE=4 SV=1
---------------------------------------------------------------------KEKVHQQQALSRFVDRVMDTIDDLLVVIDTE
GRILRLNTAVERELGLTEAELLGTG---IDELLTPLEQQHLAPIRSVLL---Y--L-LGKNRDNAKSIYWL----SLLHSEQGKLEGAVVTALNITELKN
RETQLQLSAKVFENSSEAIFITDPQGTIMEVNAAFCSITGYERSEVLGRNPRILKS--HD---YKRLWRSLLDEGGWKGEIWDRRKNGEFCPMLLSINAV
ADKLGQLTHYVAISTDISQQKQTERELKQLAYYDVLTSLPNRSLFKNRFEHEICLAERNNTRLALFFLDLDHFKNVNDTLGHWAGDCLLQITSTRIQSCL
RKTDTVARMGGDEFTIILPGLTGTDATELARKLIDAMTKPVQIKDHTVFVGVSIGIAIFPDDGNDFYTLTKHADTAMYAAKAKGRGLFQYYEEGMNEAAH
QRLLLENALRLAIEREEFQLYYQPKADSNLSRITGAEALIRWRRPGFGIIPPDRFIAIAEETALIIPLGKWILKTACLQAKVWVNQLP-GFRLAINLSPL
QLLADDFIVVLDRILAETDTKPEWIELEVTEGLIMLDIVKATERLHQIRERGIHVAMDDFGTGYSSLSYLQKLPIHTLKIDRSFIMAYTNDSSEAAFIKT
IVSFGQVLNMTVVAEGVETESQLALLQSYGCDEIQGYYLSPPLPADEFQR----------
>tr|H8GMG1|H8GMG1_METAL PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Methylomicrobium album BG8 GN=Metal_3005 PE=4 SV=1
---------------------------------------------------------------------KERAEQEKAFARFVNRILDTMDDLMFFFDKK
GRIRRVNTAVERELGFTEADLVTSC---IDDLLPVADRQYLAPVHSVVM---C--L-LSKHLDNAQAVYWL----SVLHSEQGKLEGAVITALNITELKV
REMRLRLSSKVFDNCSEAIFITDPQGTIQEVNDSFCEITGYERGEVLGKNTRLLKS--HD---YKQLWHSLLNHGSWRGEIWDRRKNGELCPMLASINAV
YDDQDQLMHYVAVCSDISQQKQTEQQLQQLAYYDALTQLPNRALFKDRLEHEIRVAQRSHTRLAVFFLDLDHFKNVNDTLGHWVGDYLLKIVASRIQRCL
RESDTISRLGGDEFTIILPGLIGADSTELAQRLNDEVQKPIEIAEHAIHVTTSIGIAVFPDDGNDFHTLTKHADTAMYASKAKGRGQFQYFEAGMNEAAH
QRLLLENALRLAIEQEDFQLHYQLKVGGSLERIAGAEALIRWKRPGFGMMPPDRFISIAEETGLIIPLGAWILRMACLQAKAWKDKIA-EFRIAVNLSPR
QLLDDDFVSILDRILAETGTSPEWIELEVTESLVMHDIDKACERLCQIRSRGIRIAMDDFGTGYSSLSYLQKLPLQVLKIDRSFVQAYTGDSSEAIFIKT
IIALGHSLNMTVVAEGVENESQLAVLKAHGCDEFQGYYFSPPLSADEFER----------
>tr|H0PZQ6|H0PZQ6_9RHOO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Azoarcus sp. KH32C GN=AZKH_3255 PE=4 SV=1
---------------------------------------------------------------------TEA-------NNKLRLFIDNAPAGIVMFDAS
RRWLQRQVKLHDVVGR--------N---YREIRLTTD-----EILLRCVAE-----DDEALPLPDGGTCWM---IHPWHDADGVVGGIIVMIEDITDRKR
A------EEQAFQ-SRDGMIVTDAEGTIMQVNQAFTDVTGYTAEDAIGKRVALLHSG------YRNMWEAIAHEGRWEGEIWNRRKDGGIFPGWLTISGI
GDAGGKITHYLGTYADISEPREATRKLLELAFYDPLTALPNRRLLLDRLHKAIAASARSGQFGAVLLIDLDHFKTLNDTRGHDIGDELLIHVARRLRELI
RGADSAARLGGDEFVVLLEGLNEQLTETIAAKLSIAISRPVILKGEIHHVTPSIGVTLFHHATQDAEALLKQADLALYQAKDAGRNAVRFYNPAMQAAVE
ARVRLEAGLRRALTADEFVLHYQPQVD-AAGRLIGAEALLRWRPPGQPMILPADFIPVAEDSGLIVPIGRWVLDTACRQLAAWSDAPTRDLQLAVNISAR
QFRQPDFVEHVRMAVRSSGANPARLKLELTERYVLEDIEHVVRTMQMLKQDGVGFSIDDFGTGYSSLAYLKRLALDQLKIDQSFVRDIADDADDRAIVHA
IISLAESLGLQVIAEGVETAAQFDFLAAHNCQGYQGYLFGRPGPVEQMDT----------
>tr|C6WUZ4|C6WUZ4_METML Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylotenera mobilis (strain JLW8 / ATCC BAA-1282 / DSM 17540)
---------------------------------------------------------------------QQKNQETVQREQYLRALMDTFPFIVWMKDKS
GRFMATNRKFVEVVGAKHYEDLGKT---DFDFFPTEMAQGYACDDEEIL------SFNEQIKKETGEIYWAETYKSPV-QLDGQVIGTVGFARDISEKQH
LVSEVTKQRNLVQNLPTTIIRYDLDGKRIFVNSR-----------------FETYNYP-W-AEQFNVQKTLEIHSMHEQLRIVFDEVHQV----------
-------CGALTIATDITEVAEYRRKIESMAFHDQLTGLPNRTLFSQQLSVAIDQAKTNNSQFALIILDLDQFKSINDTMGHAIGDKLLIEVARRITNSL
DQHCTCARLGGDEFIILVESVPSEHVEYVSNVLLNQIMQVYVIDGSEYFISASIGIAYFPDDSEDMDDLLKYADSAMYHAKKGGRNRYHTYSPAITESIQ
HRLNVETELRRAIENDEIYLEYQPIVDMTSNQVKGLESLCRWHSRKLGIVSPMVFIQIAEETGMIVELGQWIMREAFKAARLLNAQLKHPVSVSVNLSAR
QFFEVDLIHQVRHLLKEQQCNPAWIKFEITESLLLESNQSVLNALNAFNDLGIKVSLDDFGTGQSALAYLSKFPIHQVKIDYSFVKEITSNPNDALLVKA
IIALTATLNKELIAEGVETSAQATLLQSYGCRYAQGYLYSKPISLQAVQQ----------
>tr|A0A011PY81|A0A011PY81_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-11 GN=gmr_6 PE=4 SV=1
------------------------------------------------------------------------RDALRASEARFRAISDASPLGIFVSDEE
GRCVYTNAAYHTISGLSLAETLGTK---WSTAIHPADRQRVL----EAV-R----RTEFRFLQPDRSIVWTRVNSAAM-SEGMHSGGRVQTVEDITERKS
IELALRAAEETLDSIGDAVLSTDLLGRVTYLNAVAETMTGWARAEARGRPLPEVFHRP-NRSV---LLRRDGVE-YAIEDSAAHDRDGRVSGAVIV----
-------------FHDVSESRAMVRKMAHLAQHDFLTGLPNRMLLKERLARAMGLARRRCKQVALLFIDLDCFKHINDSLGHAVGDQLLQVVAGSLSACV
RTTDTVCRQGGDEFVILLSEIEQQDAALVAEKLLVALAEPQRIGE-ELHVTLSIGISVYPDDGASVDAVLQNADTAMYHAKAGGRNKYEFFTANMNSHAV
RRLFVETSLRRALRQGEFVLHYQPQVDLASGALTGSEALIRWRDPILGLIHPKDFVAIAEQCGLIVPIGRWVLREACRQNQSWLQAGLHAVPVAVNISAV
EIRQKGFVDGVARILNETGLAPCFLELELTEGSLMHDTEASALVLGELKAMGVKLAIDDFGTGYSSLSCLKRFPIDTLKIDQSFVCDLVSNADDATIVSA
VIGIGRNLKQRVVAEGVENRAQLAFLRSQQCDEGQGFLFNRPLSAKDFAG----------
>tr|Q47ED8|Q47ED8_DECAR Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (
------------------------------------------------------------------------RQALTLSEARFRAMSDASPLGIFVSDIH
GECVYTNAAYHKISGLNLEQTLGTN---WSMAIHPDDRQRVL----AAA-L----QTEARFLRADGSIVWARLNAAAM-LDGLHLRGHVQTVEDISERKI
-------TEDTLNSIGDAVLTTNLKGDVTYLNLVAEMMTGWPREAAIGQPLSEVFRRP-NRSI---LIHRDGLE-AAIEDSAAHNRDGQVAGAVIV----
-------------FHDVSESRAMALKMAHLAQHDFLTGLPNRALLTERLSRAIGQARRHNKRVGMLFLDLDYFKHINDSLGHAVGDQLLQQVAERLIVCI
RDTDTVCRQGGDEFVILLAEIEQRDAAPIAEKLLAAFAEPCLIAG-ELHVSLSIGISIYPDDGMDADTVMKNADTAMYHAKANGRNNYQFFTTEMNTRAV
RRLFIEGNLRRALRQGEFMLYYQPKIDLASGMMIGSEALIRWQDPEHGLVYPKQFVPIAEESGLIVPIGSWVLREACRQVRAWQESGLVAVPVSVNISAV
EFRHKDFLEGVALILKETGMLPSYLELELTESILMHDAESSATVLEALKTMGMQLAIDDFGTGYSSLSYLKRFPINTLKIDQSFVHDIAIDPDDASIVGA
MIGMGKNLKQRVVAEGVETEEQLAFLRTLHCDEGQGFLFGRPLPADEFAR----------
>tr|F5RA73|F5RA73_METUF Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor S OS=Methyloversatilis universa
------------------------------------------------------------------------ARALRFSETRFRAISDASPLGIVVTDAQ
GLCTYTNDAYQSMSGLDARHVAGRH---WSCFIHPDDRARVQ----AVL-Q----SGEMRLLQRDGEVVWARMHAAWM-TDDGAPQGCVQTVEDITDRKK
AENALLQAEETLNSIGDAVIATDSQGRVSYLNQVAESMTGWSAPEALCRPLSEIFARP-NRCL---LVRRDGVE-LPIEDSAAHDRRGRVTGAVIV----
-------------FHDVSQSRAMAIRMAYMAQHDFLTGLPNRALLTERLAQAIGQAARHHKQVALLFIDLDFFKRINDSLGHAVGDQLLQCVAERLIGCV
RATDSVCRQGGDEFVILLAEIEQQDAAGVADKIHQAFLEPQQVGG-TLQITLSVGISVYPDDGNTAEAMMRNADIAMYHAKAQGRNNCQFFTPEMNERAV
QRLLIEGGLRRALGNQEFRLHYQPQINLASGAVTGAEALLRWRTPDHGLVSPTQFVPIAEECGLIVPIGQWVLREACRQIRAWQDRGLCVVPVAVNISVV
ELRRPGFAESVARILYETGVPPHLLELELTETRLMQDAESSMSVLRSLKSIGVKLVMDDFGTGYSSLSYLRRFPFDVLKIDQSFIHDLDSEDGDAGIVGA
IIGMATHLRQKVVAEGVETEQQLALLRIRQCDAVQGHLVGRPMEADGFAG----------
>tr|A0A075JXT4|A0A075JXT4_9GAMM Diguanylate cyclase OS=Dyella japonica A8 GN=HY57_02970 PE=4 SV=1
------------------------------------------------------------------------ELQLRESEQRFFGAFQHAPIGMALVTID
GHMLRVNAALCDMLGYSEQELLTRA---LPDLTHVDDLPASR----SLREG----QLEKRYIHRDGHVVHVLLSVSAVRSINGEPNHAVAQILDISQRKA
-------YEETLRSIGDAVITTDLQHRVTSLNPIAEAMTGWSQAEALGKPMSEVFRRP-DAAV---LLHRNGFE-TPIEDSAAHDHAGSVIGGVLV----
-------------FHDVSETRALALKMAHLAQHDTLTGLPNRSLLQSRLEQVLAAAVRRHDEAALLHIDIDHFKQINDALGHTAGDDLLRSFAAHLRHHL
RNEDTVSRIGGDEFVVLLSHVDGSGASQLCEKLMRLWQASP-ASKGEFNIDFSVGISVYPDDARDAESMLRNADIAMYEVKMQGRNDYRFFTSQMSELPA
ARLRIEQDLRRALKRGELRLHYQPKVDARSGAIVGAEALLRWQVDGQDVYLPDQFIPVAEESGLIVPIGEWVISEACRQAGEWYRAG-RPIVVAVNVAAP
QFQHPGFHATLRNALEEAQLPPSLIELELTERMVMSAGDQSRALMQGIKDLGVSLALDDFGTGYCSLSYLKYFPIDALKIDRTFVRDIASDADNAAITDA
IITMARGLEMNVVAEGVETTAQAEHLRRAGCSLLQGFLFGTAIPAEEFSQ----------
>tr|A0A023NXD6|A0A023NXD6_9GAMM Diguanylate cyclase OS=Dyella jiangningensis GN=CH75_20705 PE=4 SV=1
------------------------------------------------------------------------ETRLRESEQRMNGAFQHAPIGMALVTPG
GFMLRVNDALCQMLGYDEQELLSMS---LVDITHPDDLATSR----SLREG----QLEKRYVHRDGRAVHVLLSVSVVRRAEGEPFQAVAQIMDISQRKA
-------YEETLRSIGDAVITTDLAHRVTSLNPIAEAMTGWSHAEAVGKPMSEVFRRP-DAAV---LLHRNGFE-TPIEDSAAHDHAGSVIGGVLV----
-------------FHDVSETRALALKMAHLAQHDTLTGLPNRSLLQSRLEQVLAATVRRHDQAALLHIDLDHFKQINDTLGHAAGDELLRAFATHLREHL
RSEDTVSRVGGDEFVVLLSHVDGSGASQLCEKLMRTWQASP-ASRGEFTTGFSVGISVYPDDASDAEMMLRNSDIAAYEVKVHGRNGYRFFTPSMSERPA
ARLRIEQELRKALRRGELKLHYQPKVDARTGAIIGAEALLRWLVDGQEIYIPDEFIPVAEESGLIVPIGEWVLREACRQTGEWYRSG-RSIVVAVNVSAP
QFQHPGFHATLQAALAEAELPPALIELELTERMVMSAGDQSRALMQRIKDLGVSMALDDFGTGYCSLSYLKYFPIDALKIDRTFVRDIASDADNAAITDA
IIAMAHGLDMVVVAEGVETSAQAEHLREAGCALLQGFLFGSAMPPEEFER----------
>tr|H8FTR7|H8FTR7_PHAMO Putative Diguanylate cyclase OS=Phaeospirillum molischianum DSM 120 GN=PHAMO_290062 PE=4 SV=1
---------------------------------------------------------------------DR-ASSMARLARRLQAISEQASQAIYVKDEC
GL---FNSAAERMLNRTADDVIGRD---D-HVLFPADEAA--EIDRKMMAER--G----------------SVTKAPLLDTSNRVVGIIGVSRDITELLM
ASEALRRSEAMFENMLSGFAIRENGRPVDFTNPSFEVQTGLK----TGKLVSEMFPDE-----------EMGVR---VAETGQ-KHEGLNIWFVS-----
----TEDGLLAIIFENITERKTAEQKIEHLAYHDSLTGLPNRLLAQDRMTQAAAHAQRDRTMAALLFLDLDSFKGVNDSLGHSCGDDLIRAVAERLSNCV
RDTDTISRHGGDEFLIVLTGPRTDAISTTAGKILAQIAQPFDIQNQTLLTTASIGIAVYPGDGTDFATLLKKADTAMYHAKEEGRNTYRFFDERMNVGVA
ELLRMRNGLRNALDHDEFELHFQPQIDLASGRVIGAEALIRWNHPELGRVSPDRFIPVAEESGLIVPIGEWVLREACRRAAAWQKEGLAGVTVAVNLSAL
QFKRGNLKQTVTDALAEFGLDPTCLELELTESILIKDVEEVLATVFQLKSLGLKLAIDDFGTGYSSLSYLKRFKVDKLKIDKSFVRDLASDPDDAAIIRT
IIQMAHSLNLRTIAEGVEDQEMLDRLRLFHCDEIQGYLIARPMPIDDFIA----------
>tr|Q3SJL3|Q3SJL3_THIDA Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) and Response Regulator Receiver mod
---------------------------------------------------------------------RRERRQTEHLVRRLSQAVEQAADSVFITDRQ
GTIQYVNPSFERLTGYSAAEAIGRT---PA-LIKS-------AFFHKLWDTIGFYFDE-----------------------GRGIAGFVSTGRDVTDRIR
DEQTRGQLLE--EATTDFVAIIEGDGRLRY--R-------------AGRAVLGLTAEHEWARL----FPTARRDGAWQGEIAARLADGREIPVSQVVL-A
HGGA----FFSTIARDITERKHFEQELRRQATHDALTGLPNRILLEDQIEAVVAHSARSHKLASVLFLDIDNFKRINESLGHAAGDAMLRHAAQRLRDCV
RPTDVVARYGGDEFTIVLGDLSHDNIPAILHKVRAAFETPLVISGQEVYASFSVGVSVYPHDGDDGATLLKNADTAMYRSKASGRNRYQFYAPEMNARGQ
ELLSLETDLRRALDRGEFRLHYQPQLDLRDNRIAGVEALLRWKHPRDGVIAPGDFVPLLEDTGLIVPVGEWVLRNACTQYRACRESGVAPVRISVNVSAR
QFREDTLLRQVEQVLREECMPPHHLELEITESTAMQDVAATGDILAALDALGVRLAIDDFGTGYSSLAYLKRFPLDALKIDQAFIRDAPRDANIAAIAEA
SISLGHKLGLEVVAEGVETAEQLAFLRRRACDLIQGFHFSRPLPADALTP----------
>tr|Q47A14|Q47A14_DECAR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (strain RCB) GN=Daro_3588 PE=4 SV=1
---------------------------------------------------------------------RT-------QHNQLQTVIESIPSAVSLFDSA
GNLVLFNTAFPRLLD---------V---PAELAKPGVSMETLEYGPGDP------YFE----RTRP-----------VRGVPLAEGGFVTVYTDISERRA
SAEREQLAQK--SHTPAGIIFTDDQHRILSINPA-TEMTGY--EPFIGQTVFGLISD---------FQEQISMRGSWSSELEVTQKNGSNFPAGAR---V
DDPQ----HYVWILADITERKQAEDRMRHIAQHDALTGLPNRLALLMRLAQLLPEARRHGWTVAVMFIDLDRFKIINDTLGHQVGDEMLREVACRLSNLL
RETDFVARLGGDEFVIILPSISSADAAIVSGKIISALSTAIEAEGHELHTSPSIGISIFPDDGPDGDIVLKNADTAMYHAKAAGRNNYQFFAADMNRTAA
ERLNIERKLRHAIARNELSLVFQPQFRAEDTTPTGVEALLRWHHPTDGMISPARFIPVAEETGMIVEIGDWVLATACHEMARWINAGLKPLRIAVNVSAR
QLRRRDFCETVANALTTSGLPAELLELEITESSVMENPQEAIHILERLGRMGVTLAIDDFGTGYSSLAYLKLFPIDHLKIDRSFVADIEHDLNDRAIAFG
TIALAHSLGLNVIAEGVETEDQHELLRANGCDEVQGFLFSKPLTGAAAFA----------
>tr|I4VPP6|I4VPP6_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodanobacter spathiphyll
------------------------------------------------------------------------ELQLHESEQRFFSAFQHAAIGMALTKPD
GQFLRVNAAVCQMLGYSEQELLQQD---IGRLSHPEDVAADQ----QLLAG----QLEKRNFHKLGHVVHILLSVSLVRDAAGTPLYFVSQVQNISQRKA
-------FEDTLRSIGDAVITTDPQVRVTSLNPIAEAMTGWSSAEANGRPIEEIFQGP-NLTL---LRHRHGFD-TPVEDSSAHDHAGNVIGGVLV----
-------------FHDVSENRALALKMIHLTQHDTLTGLPNRSQLPGHINRAIDSASRRRQRAAVLYIDIDNFKQVNELVGHTAGDQVLRSFIGQLQRCL
TGDELLSRYGGDEFVVVLPHVDSGEAAVLCRNLITHGEQTR-IAGPELSLHLSIGISVYPDDATGADELVQHAETALMAAKAQGQHGYRFFTASMNERAR
AQRRIETGLRQALPGNQLKLHYQPKVDAHSGRIVGAEALLRWQLNGRDLYKPDQFIPVAEDSGLILPIGAWVLRQACRQARMWQQAG-HEIPISVNVSPL
QFQHADFYTWLDDVLEEAGLESRLLELELTERMVMSGGEATTGLLQRIKHRGVRLSLDDFGTGYCSLSYLKHFPIDALKIDRMFVRDIISDHDTATITSA
IIAMARSLNKDVIAEGVETREQGSFLRHAGCSQLQGFLYGMPMPASELQK----------
>tr|M4NTX6|M4NTX6_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Rhodanobacter denitrificans GN=R2APBS1_3869 PE=4 SV=1
------------------------------------------------------------------------ELKLHESEQRFFAAFQHAAIGMALTRPD
GRFVRVNAAVCQMLGYREEELLQLD---IAAVTHPDDLAADA----QLLAG----QLEKRNFHKDGRVVHIQLSVSLVRDEQGAPLYFVSQVQNISQRKA
-------FEDTLRSIGDAVITTDPQLRITSLNPIAEAMTGWTGIEAAGRPIEEIFQGP-NSTL---LRHRHGFD-TPVEDSSAHDHAGNVIGGVLV----
-------------FHDVSETRALALKMIHLTQHDTLTGLPNRSQLHEHIGQAIATANRRQQRAALLYVDIDNFKQVNQLHGHAAGDRVLRAFAAQLQHCL
SGDDLLSRYGGDEFVAVLPHLESGEAASLCQRLINHGEQTR-VDGPELGLRLSIGISVYPDDAVEPDGLLQHAETALVAVKAQGLHGYRFFTASMNERAQ
ARRRIEAALRQAQPRHELELHYQPKVDAHSGRIVGAEALLRWQADGHEAYAPDQFIPVAEDTGLILPIGAWALRRACRQARRWQDLG-HAIPVSVNVSPL
QFQHAEFYNWLDEVLEESGLATGLLELELTERMVMSGGDATTGLLQRIKRRGVRLSLDDFGTGYCSLSYLKHFPIDALKIDRVFVRDITSDRDTATITSA
IIAMARSLNKDVIAEGVETYEQGAFLRHAGCSQLQGFLYGAAMPAAAFEQ----------
>tr|I4WBZ8|I4WBZ8_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodanobacter thiooxydans
------------------------------------------------------------------------ELKLHESEQRFFGAFQHAAIGMALVAPD
SRWLRVNAALCAMLGYREDEFLSRT---THDITHPDDVAASD----QMLEG----HLEKRYSHRNGSLVHAQLSVSLVRDDDGNPRYFVVQIQDISQRKA
-------FEDTLRSIGDAVITTDPQLCITSLNPIAEAMTGWSGLEAQGRSIEEIFQGP-NTTL---LRHRHGFD-TPVEDSSAHDNAGNVIGGVLV----
-------------FHDVSETRALALKMIHLTQHDTLTGLPNRSQLHEHIGQAIATANRRQQRAALLYADIDNFKQVNELHGHAAGDRVLRAFAAQLQRCL
SGDDLLSRYGGDEFVVVLPHLESGDAASLGQRLINHGELTH-VDGPDLSLQLSIGISVYPDDAIEPDGLLQQAETALVAVKTQGRHGYRFFTASMNERTQ
ARRRIETALRQALPRHELELHYQPKVDVHSGRIVGAEALLRWQANGRELYQPDQFVPVAEDSGLILPIGAWALRRACRQARAWQDLG-HAIPVSVNVSPL
QFQHPEFYHWLDEVLAESGLAPGLLELELTERMVMSGGDATTGLLQRIKRRGVRLSLDDFGTGYCSLSYLKHFPIDTLKIDRVFVRDLTSDRDTATITGA
IIAMARSLNKDVVAEGVETHAQVAFLRQAGCSQLQGFLFGAALPAAEFQA----------
>tr|G2IW82|G2IW82_PSEUL Diguanylate cyclase/phosphodiesterase with PAS sensor(S) OS=Pseudogulbenkiania sp. (strain NH8B) GN=NH8B_0396 PE=4 SV=1
---------------------------------------------------------------------RE----REQLF---RGTFEQAAVGIAHLGLD
GHWIRVNQRLCDILGYSREELLRLT---LQDITHPDQ-DSG-MTRRLLAGE----K---RYRQRRGQLVWA---AALMRDEGARPEYFILVVEDISARKQ
S------EEAVFDSMLEGVIITDHHRRILAVNAAFGEITHYPVEALLGRTPPLWRTA------YRRIWRQLLASGRWEGELWHRKRDGTPFPLWLSISCV
RDEQGRPRQYVFVFNDISQLKDSQEQLERLAHYDPLTGLPNRHLALARLEHALERARRHAFPLAVMFIDLDRFKTINDSLGHQAGDELLVAIAQRLHQRL
RQEDTLARLGGDEFLVVIEEAPVQV-ASIAHALLKVVDQPCSFSGGEAYVGASIGISLYPGDGRSASELIRNADAAMYLAKAQGSNAYRFYTESLTRAAN
ERLSMETSLRRALRREEFVLHYQPLVELASGRVLGAEVLVRWQPPGEALVPPSRFIPLAEETGLIVPLGDWVLHEACRQGKAWLDAGLPLL-LAVNLSPR
QFLRHDLVGQVRKALQGSGLPPAQLELELTEGALMEQAEQAVKTLNALKRLGVSLAIDDFGTGYSSLAYLKRFPLDKLKIDRSFVRDLPRDSSDAEIVTT
IIAMVRNLKLEALAEGVETQQQLAFLRQLGCDSGQGYLFSPPLPAAAFER----------
>tr|H0Q3D9|H0Q3D9_9RHOO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Azoarcus sp. KH32C GN=AZKH_1561 PE=4 SV=1
---------------------------------------------------------------------KEV-------LDEHRVIFDNAHVGIAYIR--
-----CNQRMAEIFGYDGPEELSGQ---RTLMLYPAD-----EQGIRLYHQ----EEEVELRRRDGQPVWC---GRPIDP-TEPHGGSIWAYSDISAQKR
Q------QHQVFDNSSEALLICDRDNRIVSVNRAFTRITGFSAAEAIGQTPSILRSG------YREMWDTLLSSDHWEGEIWDRRRNGEIYPKWLSISVV
RDEPGQVTHYVAAFSDVTLRKHAEERAQFLARHDVLTGLPNRMLLRERFEQSAEHARRTHRKLALLFLDLDHFKRVNDSLGHPVGDAMLIAVAERLRVAV
YGTDMIARLGGDEFVILLENVEHEDIAKVAAKIDRCMQAPISVGGQLLSTSFSIGVAVFPSDGQDFDTLLQRADTAMYHVKESGRGTFSHFDEQMNVQAS
ERLSLHARLRQAIDGDEFALVFQPQVNLRDGRVFGAEALLRWNPREGGAVGPDRFIPVAEESGLILPIGEWVIRQAFHQARRWLDAG-TPMQLSINVSGL
QIYRSDLLATLTAVQRDTGVPPQMIEIELTESTLMEDVQTVREVLDALKRAGYSLSIDDFGTGYSSLAYLKKFPIHRLKIDRSFVTDLCTNPEDQAIARA
VIQIGHALNLRVIAEGVETAEQMSLLKQHGCHEGQGYFFGRPVPAERLAV----------
>tr|G7WFV7|G7WFV7_DESOD PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Desulfosporosinus orientis (strain ATCC 19365 / DSM 7
------------------------------------------------------------------------SEERFRDM------VETMNSATFKISDD
GICTDINPVAERVENISRNQAIGSS---LTHVF-PM------EIDKLLF---E--FDN-------------GWSEGVI--YKLSTGSIVVLYDEVS----
---QRVLSEDTLASIGDAVLTTDVFGVVTYLNPVAEAMTGWKNEDAEVERVFDIFHSPEDRIL----KRKDGLRYYHIDDSAARDRNGQVIGAVLV----
-------------FHDVSEKRELLHRLSHQAHHDSLTDLPNRQLFIDRLQQAILHALREQLLVAVFFIDLDEFKLVNDTLGHAAGDSLLCQVGKRFKAVL
RQGDTVARQGGDEFLILLPCLKSRHAAHVAQKLLDVFNTPFQLLNQEVYITASLGIALAPLDGEEPEVLIQRADMAMYHVKAEGRNSYSFYTRDLNERLA
ERLSLQNEMRRALERQEFLLYYQPQYRLSDGQFCGMEALIRWQHPERGLLLPGSFISIAEDSGLILALGEWVLRSACAQNKFWQDMGYPPLRLAVNLSAR
QFRQKNLVEQISQILEETGLDPQWLVLEITESISMENVVASVEILQKLKNMGIHLAIDDFGTGFSSLSYLSRFTLNTLKIDRSFVSILDKSAGGHAIVLT
IIQLAKNLGLNVLAEGVETRVQLDHLRSMGCDEVQGFLLGKPVPKEEIVS----------
>tr|Q2RPL3|Q2RPL3_RHORT Diguanylate cyclase/phosphodiesterase OS=Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 
---------------------------------------------------------------------RA----AEGKY---RAIFENAVEGIYQSTPD
GTYLDVNPALARIYGYASPAELIAH---FTDIASQYV-DGT-EFQRLMRET----A---EVWRCDGHTIWI---ARCVRGPDNEVLYYEGTVEDITAQRQ
S------QETVFTSIAEGIVLLERDLTVRTVNPAFEAMTGLLRQDMEGRPARLFASG------LATVAAEVDRAGLWRGEIWGERREGPPYSGEMTVTAV
RTRAGETTHYVAAITDITKRKRDEEHIRFQANFDMLTHLPNRHLIMDRLEQAMHQAQRTGRQVCVMFLDLDRFKQINDSYGHSAGDEVLKLTARRLRNCV
RISDSVGRLGGDEFIVILSNVEDHAGAYIAEKILYSLSEPFPI-GTEVFCIPSVGITYFPDHGETAPDLLRNADVAMYHAKQGGERRYAIFTPDMARRSL
ALLTMESDLRHALARDEFELHFQPKVRA-DLTLIGAEALIRWRHPEKGLINPGDFIPLAEESGLILPIGRWTLREACDRVMSWRAEGLTIPSVSVNVSPR
QFQDQTLVETVRQILVETGLEPEALDLEITETVMTGDVEHAVGTLRALKDLGVTLSIDDFGTGYSSLNYLKTFPIDTLKIDQTFVRDVLHSGKDAAIVST
IIALARNLGFSVVAEGVEEIEQAEFLGSRDCQNFQGFLYSRPLPPAEFTT----------
>tr|A0A098F569|A0A098F569_9BACI Uncharacterized protein OS=Bacillus sp. B-jedd GN=BN1002_04729 PE=4 SV=1
---------------------------------------------------------------------MDLAKKLRISEKIKLNILNALPINIFLEDRE
GRTVFVNDQVVKAHGMKREELLGKT---VFDFFPRHIAEMNRKVDEEVWRQ-G----------FQGEERELLTGKTVIQA--ENEDFLLGFALDITDRVN
AEKMLKESEEVVDQAADGIFLIKIDGSLSNVNAAAAAMLGYQKEELLERNVSEIFEK-EDN-----LAASDGTR----------------IPV-------
----GGKNKYLALGRDIRDKKKAEKAIQHMAFHDALTGLPNRWYIQSFMLKYFL--KKSQGKLGVILLDLDHFKVINDSMGHEAGDSLLIDVAERLRAVC
LDGMIAARFGGDEFIVLIPDINSEAALAVGEEIFSALEKPFFIGSQKVIVTASIGISISPEDGSELNELLRNADLAMYRSKENGRNCCRLYDSSLNDKAV
ERLAKEIALHQALEKGEFLLHYQPKLNLKTKEVYGFEALLRWRKG-GKLLYPDRFIEVAEETGLIVQVGEWVLREACRQCQEWHKQGMEQISVSVNLSPR
QFQRQDLGRLIAEILEETTLPADKLELELTESTVMKEPEEAAQVLGQLKMLGVSIAIDDFGTGFSSLSYLKHFPIDVLKIDRSFIHNLEWEEANASIASA
VISLGRSLKLKIVAEGVESREQLSFLEGNSCDFAQGYYISRPLDAKSAAS----------
>tr|G7W850|G7W850_DESOD PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Desulfosporosinus orientis (strain ATCC 19365 / DSM 7
---------------------------------------------------------------------DREMLECYRLL------ADEVLDIIIFIRPD
GD---ANEATVKRYGYTRE-----E---LTN-M-PV------PEDHSAI---MFEPVD-------------GAT------YN-GKPVIVSLIRDISKRK-
------KAEATLESIGDAVITSDVQANVDYINPVAETLTGWSNAEAPLEKIFNIINGPEGRAL----INKDGLM-ISIEDSAARDRDQTIIGAVLV----
-------------FRDVSYKRNHMKELAHQAQHDALTGLPNRLLFNEHLKQALAQGKRKQGKLAVMFLDLDRFKLINDTMGHNLGDQLLKTVAERIRQTL
REGDTVARQGGDEFLVLLPEISNFEAALVSERILGVFAKPFLLDGSEIYISTSIGISLYPDDGSDLETLVKQADTAMYYAKEKGRNNCQFFTEGLNLKAN
QRLFTENSLRKALSREEFVLHYQPQVDLVSGNIVGLEALIRWNSVELGLVSPAAFIPIAEETGLIVLIGEWVLRTACAQNKRWQKQGYLPLRMAVNISAR
QFREPSFIKLVEEILQETELDPKWLELEITESIAMDKSEASLQMLGAFKELGVRISIDDFGTGFSSLNYLRRMPIDTLKIDQSFIKDISTGEHGEEVVTA
IIQLAKNLKLKVIAEGVETNGQRSFLKEKLCDEMQGYLFSKAVPCNEAER----------
>tr|E8V8S1|E8V8S1_TERSS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Terriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR
---------------------------------------------------------------------ARTSKQNEQ---YFLAVSNSSSDSILVRNEA
KRFVFANSNGASLVSSTPAKLVGQL---LST-IFPF----------------FDRTEEFPVESADVNATWL----HQIIK---VDDGIAITATDISAKKH
AEIKLGKTLALIDNSPFPILALELDGTIREINPAAERMLEYTNEELAGRATPLILHDAHELLI---YIRKGGSHVI-VEISVTTDE--------------
----QKVNGWLCVAYDITERKHTEEYISHLAHHDSLTGLPSRALLNDRMELALKRAHRNSSKVALMMVDIDNFKRVNDSLGHSVGDNLLISVAQRLQHTI
RETDTVARMGGDEFIVLIDDVRSEEAEKIAEKLVAVMAAPVTINGEQHPISASIGLCLYPEGGGDLDALLKNADEAMYFAKAEGRNMYQIFSKDMASATA
KRRTIENALDCALSRNEFDVVYQPQISFQSGKVTGIEALIRWNSKLLGNVTPAEFIPVAEQTGLIVPIGEWVLRTACKDARRLEEKLGHGLTIAVNLSPR
QFQQENLPEIVSDALAESGLEPKHLELEITENILVNDSRKAMRVLDRVRALGPRIAIDDFGTGFSSMSYILRFNVDRLKIDQSFIRNIMTEPNG-AITRA
IISLAKGLKINVVAEGVETAEMSEILLREGCDEAQGYFYSRPVAFGEIEE----------
>tr|W9UT37|W9UT37_9GAMM Bacteriophytochrome cph2 OS=Nitrincola sp. AK23 GN=cph2_11 PE=4 SV=1
---------------------------------------------------------------------DRL---PEQSS--EPTEFDLVLIDYRLPGKD
GLELVR--------ELRHTRQLTLP---LVLITGQSE-E---VIAQA--------D---FISKHDGYLY---------------AAFLEKVCRTSELRKE
HRELLKLNAAVFDSTSEGVLIADLKPTILAVNKAYTEITGYAEAEVLGKNPGFIKSG------YQTLWKSLAETGSWRGEIWNRRKTGEVFPQFLSLNTV
VNEQGQATHYVGIFNDLSYQKESEQRLQTLTHYDPLTQLPNRLLLLSRIDHAIDQAEGQDRQVAVLYLDLDRFKNINDSYGHQEGDGCLKALAQRLSHHL
GKEDTLARTGGDEFIVVLEGLSHERAAQKAESLLELMQKPIVLSGLEVVCAASIGISLYPQDGTTATELIQYADTAMNQAKSLGRNTYRFFTEELTIQAR
CRLDLENSIRKALKDNEFVLHYQPVIDAHTQRVVGAEALVRWHQNKQNLLGPDRFIPVAEECGLIIPLGRWVLRQACQQMRHWLDMGIHLEFMAVNLSGV
QFNLGSVEQEVFEALQRSGLPPSFLDLELTESIIMNYGSQSLSVMNKLKEQGVSLSIDDFGTGYSSLAHLKNFPVDRLKIDKRFVQSLEEQTKDMAIVTT
IINMAHNLGMKVVAEGVETQAQQALLKQLECEFFQGFYFSRALDEDAFAD----------
>tr|C6XBS8|C6XBS8_METGS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylovorus glucosetrophus (strain SIP3-4) GN=Msip34_2811 PE=4
---------------------------------------------------------------------RAAENALRLRDEYQRALIDNFPFMVWLKDRQ
SHLLAANTAYAEWAQAASTRDVGKT---DFDLFPEEIAKAHIASDQVVL------HAVDQVKDQHGRQRWMEIYKSPVR-VNDELKGIVGYARDVTEAKL
NELEIVHREILIDNTPDAITRFDRDARRIFVNNRKDAILGKKPSEYPGGTVFSQYE-----PG----TGTTPEGETWHHIRIVLDEQGQVQHILAV----
-------------ERDITELVAYRERVYYLAYYDSLTNLPNRTLFNDRISQVLMEAQWSKQKFGVMVLDLDHFKSINDSLGHLVGDELLCATADRLQMAI
RTYDTVARMGGDEFAILLPDIRKDDLATIANKIVQVIAQPFHIQGKELFISTSVGIATYPLDGEDQEALYKCADAAMYHAKSMGRSNYQFYSHDLGSKAS
EYIAIGTSLRQALRNNEFVLHFQPQMDLLTGKLLGAEALLRWHHPLHGLLPPDDFIGVAEESGLIVEIGEWVLENAFNAIVELNRLRD-KLTVAINLSAR
QFLYNDLLAAVSRLLEKTGCLPAWVKLEIRESLLLEENPDVMAVLNAFKAMGITIAIDDFCTGYSALSYLGQFPVRQVKIDRLFMQDVVQQQDRAELVNA
IIRIAQALHLELVAEGVESASQLAFLREKGCTMAQGFFLGKPMLLEELKQ----------
>tr|Q1GXN7|Q1GXN7_METFK Diguanylate cyclase/phosphodiesterase OS=Methylobacillus flagellatus (strain KT / ATCC 51484 / DSM 6875) GN=Mfla_2737 PE=4 SV=1
---------------------------------------------------------------------RRVERELRKRERYQSALIENFPFVVWLKDLN
SKLLAANSAYAEFAGVASKDELGKT---DFDLFPLQDARTHVEGDKRVL------HSVLQVTKRNGEKAWIEAYKSPMV-VDGKVMGTVGFFRDITDIKQ
NEEKLIQRERLIDNTPDTIIRYDLNARRLYVNTPKGRLIGTTPSEYPGGEAYMKYE-----PD----HGKADNGNTWFHVRIVFGEQGQVIGVLAV----
-------------ERDITELMEYRERIHYLAYYDALTGLPNRTLFADRVNQVLADASWHEQRFGLMMLDLDRFKEVNDTLGHQAGDDLLVAVAQRLNASV
RSYDTIARLSGDEFAILLPELRNDDLATIARKINDEIAKPFLIHDKELFISTSIGIAIYPDDGDDRATLFKSADVAMYHAKNYGRNNYQFYSRELGSKAS
EYIMLGASIRQALKNAEFELFYQPQVDLMSGEIVGAEALLRWRNPQLGVVMPDRFIKVAEESGLIVEIGEWVLREACSAVVCLNRYRPHPLSMAVNLSSR
QFLYNDLLASVKDILAETGCKPEWLKLEITESLLLEDSQEIISTLSTFKEMGITISIDDFCTGYSAMSYLGQFPISQVKIDRSFVRDIAAKQDKLELITA
IIRIAHALRLELVAEGVESKQQANLLKIQGCTIAQGYFFGKPMRLRHLKL----------
>tr|Q3A017|Q3A017_PELCD Diguanylate cyclase/phosphodiesterase, PAS, PAS and PAS domain-containing OS=Pelobacter carbinolicus (strain DSM 2380 / Gra Bd 
------------------------------------------------------------------------QQRLQQELTLWQLLMERSKGG--IAVID
GKVLDVNPAFAEMLGYEPGEMLGM---------HPWEWDACRQIESRAFSSQ---FFETIMKRKDGTLRNVEVNSLPM--MVGDRKHVFCLCRDITERCE
ANKALLAREQLAENAPDAIVRYDRQLRRLYINPVLERLLGQDKATLLGKPFENHAPYA-----QTGLQQPDGT-LGWFHARFEFAEDATVK---------
--------SVMGIVRDITELVEQRELAQHLAFTDMLTGLPNRALFEKRFKEAAAEAKSTDCPFALLMLDLDHFKDVNDSLGHNCGDELLRQVTARLSHCV
NECDTIARMGGDEFAILLAESRGDEAGQVADLILSTLAQPFFIESQELFISGSIGIAFFPHDSANLDELFTYADTAMYSAKHKGRNNFQCYDQELTRHVS
AKLSLGASLRYACVNHELQLYYQPKVQLKDGRVVGVEALLRWWHPVLGMLTPDRFISIAEETGLIVEIGEWVLKTACQAAVDFNRNATAPFKVAVNLSCR
QFLQNDLAATIEAILKTTGCRGEWLECEITESLMIEDNPQVAKTLEALRSLGITIAIDDFGTGYSALNYLSRFPIDVLKIDRSFINHIDTDPCKVGLVKV
FIALGTNLEMQIVAEGVETVSESASLQKLGCGLAQGYLFGKPQPFKALMA----------
>tr|J6DHN1|J6DHN1_9RHIZ Sensory box-containing protein OS=Rhizobium sp. CCGE 510 GN=RCCGE510_27211 PE=4 SV=1
---------------------------------------------------------------------KRLQDKLERSERFFRTAFENTSIGIY--SGD
STLVDANAALCKMLGYERGELIGKT---FVDLTPIEDRYHDLVISQL-----GA-TLVKRYLRRDGQAILVSHVVHTDFDPDGTPVQGLCIIEDITEQER
MKAALNQSEKAFEFGPVGATILNSDGRYLEVNEAFVRMLGYQRHEINNRDISVAFQGPQDMGVYSERTCEIKTEEAWLHKCELLQKNGTYKWI------V
ERDDGRPLRMVGTLRDITQTVEQHQKIQKLAFSDPLTALPNRALFNSRCESALNRACIDQAIFALIIIDLDNFKDVNDTLGHLAGDQLLCGVSARLCDCL
READMLARLGGDEFAVILESLPDRTVADIAERLLASLSPPFRIAGEDLFISASIGVAAYPDQGKTADELFAHADAALYQAKARGRNNFQFYDEALAEKTE
LKLRLGNALRTACLNNELELAYQPKVKLETGHVIGAEALLRWRHPEFGLLMPASFIPLAEDNGTIVDIGRWVIRNAAQTAAILNKGRQDAIKIAVNLSPR
QFIKNDLASHVRDALEETDCHPAWIECEITESLLLENEACVQETLEQLHTLGVSIAIDDFGTGHSALAYLNRFPVDVLKIDRSFISGMDSKSRGKELVTA
FILIANALGMEVVAEGVETEEQTAVLKTLGCCTGQGYLYGKPMSLIDFKQ----------
>tr|A0A085FSL2|A0A085FSL2_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia sp. LC238 GN=FG94_01006 PE=4 SV=1
----------------------------------------------------------------------EAEHRLRKSEQRFRKLFNQAGDSIMIVDGA
LRIVAVNDQACARFGYRREEFQGML---ATDINFG-----F-TEGRALLAGLQLRPAE----------------VQISRFDDEGEEFFLAVIRDLSDRAE
AERQLRESEQVIEMTPAGYLLASRDGLLLDVNPALCALSGYPREMLLGLRLAELFVLP---AV---LRHRHGVDIHVL-FNGTRDANG------------
-----RALSLTGLMTDITGRKAAESRLQELATHDTLTGLPNRALLGERVQQMLDAC-PYGSQVAVMFLDLDRFKEVNDSFGHEMGDVLLCEVAARLRRVI
RPTDIIARLGGDEFVVAAHCASGKAAASIADKLLDLLTAPVKIGGIDVIVGASIGISMYPQDAQTREILFQTADTAMYRAKNAGRNRYRFFEPEMTVATQ
ARMALEVSLRPALARGEFELHYQPRYALCAAALYGMEALVRWNHPERGQVPPQQFIGIAEETGLIVGIGRWVLEEACLRTRELMKESGRKMVVSVNVSAR
QLAQAAFAAEVREILARTGLKPDCLELELTESALIEDIEHTAAVLRELKRLGVKLAVDDFGTGYSSLAYLRRFPIDVLKLDRSFLMQQDENVATVDFVKA
FVDMAHALGMAVVAEGVETAEVLAFLRAAHCDQAQGYYLARPMPLARLRA----------
>tr|U7GGF8|U7GGF8_9RHOB Diguanylate cyclase OS=Labrenzia sp. C1B10 GN=Q669_26905 PE=4 SV=1
---------------------------------------------------------------------S-RSDELRLSGDWLHTLLNEVSDYLYVKDRS
SRFVMANLQVALDVGLDASQLIGKT---DLELHPEETGSKF-AIEQEIM------FEE-PSILANGKRKWFSSSKYPVTNSKGEVVGIVGLSRDITERKR
ALLLQQGQNKTIEDQLDGVMLVDDTGE---------HLLAT-----VGPNLPQDYLD--TDAV---IVEDIQKDRLWESCWSVFGKDSKVLGTFGLYTKA
LEA----ARLASV-----ERDRAERKIRYLANHDVLTGLPNRQEFKTKLEEKVSESDRTGVPVAVVFVDLDNFKFVNDSFGHAIGDQVLMIVAERIMAVH
DGAHQAIRFGGDEFVLIVDRDTAKALNEFMARLRDEITKTIQIDDLSFHVTCSIGAACYPQDADSAAQLLRNADKAMFEAKSAGRDSFKVYEQTRPERSV
NKLTLLEEMRTGIENGEFFLEYQPQYNLVSGRIVGAEALVRWQHPALGRMMPGEFITLAEESGLIVPLGRWVTREACRQNKEWQESGLMPITVGVNVSAR
QFRDDGLISDVRDALEETGLAATYLELELTESLLIKNADQAVGLMDDFRRLGVKLAIDDFGTGYSSLAALKSFPLTRLKIDRSFISDLDFDESDRCIAKA
IISLGRELGLCVVAEGVETAKQQAFLASCRCEVVQGYHFGRPMAARKFGK----------
>tr|B9QV87|B9QV87_LABAD Putative uncharacterized protein OS=Labrenzia alexandrii (strain DSM 17067 / NCIMB 14079 / DFL-11) GN=SADFL11_3398 PE=4 SV=1
---------------------------------------------------------------------D-SSLDMFGDLDWLQQLVNLVSDYVYVKDRR
SRFVMANDKVAEDMGRTSAELIGKS---DLELHPPEVGQVF-EDEQSMM------VMD-RIVLPDGTEKWFSSSKYPIRKENGDVVGIVGISRDVTERQN
AEKLQRGQNEMIEGQLESGMLVDDSGN---------HILSA-----SGPNLPKSYLD--VDAV---FVEDIFDSELWASCWSVFSGSGKVLGTFAFYWTV
REA----AHLASI-----ERDRAEKRIRYLADHDPLTGLPNRRKFKRKLEAKIEASRQTGEPVAVVFVDMDNFKFINDSYGHAVGDDVLSTVADRILGSH
NITFETIRFGGDEFVLFVDGPTAKELKDYLARMRAEILKTIELDTLTLHVTCSIGTAVFPLDGDTADEVLKNADQAMFEAKNLGRDNFFIFDRETAPAGV
NRLKLVEELRRGIDNNELFLEYQPQIDLMSGRIVGAEALVRWTHPERGRLMPGEFIEIAEQTGAIISLGRWVLNEACRQNKAWQDAGLPHITIAVNVSAN
QFRDKALLSDVFSALDTSGLDARYLELEFTESLVIQNVEQAVALMEDFRRIGIHLAIDDFGTGYSSLVALKNFPLNRLKIDQSFIRDLEYKESDRAIVRA
IISLGRELGLNVVAEGVETAKQQAFLLSCRCETTQGYHFGRPMAADKFSK----------
>tr|E2CQG2|E2CQG2_9RHOB Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor OS=Roseibium sp. TrichSKD4 GN=TRICHSKD4_5538 PE=4 SV=1
---------------------------------------------------------------------N-GVPNIDKSGAWLQSIADDIADYIYLKDSN
SRFVFANAIIARDFGYSPAELFGKT---DHDVFSNEVADGF-NDEREIL------YEE-FVKYENGIYRWLSTSKFPLKTPEGKIVGILGLARDITERKK
LETLRVGQTRLIEEHFDGVLLLDSSGK---------HLLMG-----AAPSLPGFYNE--VHAA---VVSDIQTNKLWASCWSTFSKTGHVLGTFALYNRV
EEA----TRLASI-----EKMRADREVLHLAHHDMLTALPNRLKFKEKLDSLLVRCRNKNEQLALVFVDLDQFKVVNDSFGHSIGDEVLKIIAKRLKTLS
SKTDSVFRFGGDEFVILVENESVKALVPFLVDLRKSLSEAILVHGRTFHVTASLGVACFPDDGTDAETLVGRADSAMYKAKDAGRDVFKFYIPSMSQGLA
QRLTLLEEMRVGLETGEFRLVYQPQLDIVDGQMIGAEALVRWEHPYLGTLLPGRFIPLMEDTDLICQLGDWVLSQACRDAKNWNELSDDDRPVGVNVSAR
QFSDDDFVCRVNKALSESGLRPDLLELEITESLLFRNKDQAAEVMSELRDLGVQLAIDDFGTGYSSLSRLRSFPLTRLKIDKSFISDLDRESGDQCIAQA
IISLGNDLGLRVIAEGVETVAQQKILMEMGCREAQGFHFGRPMKLSDLKA----------
>tr|A9WJ06|A9WJ06_CHLAA Diguanylate cyclase OS=Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) GN=Caur_3277 PE=4 SV=1
------------------------------------------------------------------------EQQLIETQQLLHSALDALPTAIAILNQY
GQVLAANVRWLQLGPLETVDCAGAS---FLAACHLGKTAGVIAIER-LL------RYEDEFAVGKEARRWL----RVVRFGSGERVRAVVVLDDISARRK
AEQIALARRRIGEQVPDLIYVRSSNLFVSYPEEAIKHLDAWAGEVL-----ASELR-P--R-----MLSLRVDPSRWPETWMMRTNRD--VDSWLLVCRL
IEQF---EQLSLI-----EQHATLHKLAYQAHHDALTGLPNRLLFEDRLQQAIEHARRANTMVAVLFIDLDRFKHVNDTLGHTTGDMLLIQVARRFEACI
RATDTIARHGGDEFLLVLSDITSQQVTHVVRRLHEALDQPFFVNGHEIFVSASIGASLYPIDGTDVIALQRAADVAMYRAKQLLHNSFQFFDAAITDVSI
ERLQIENLLRRAIERHELLLYYQPKVD-RTGQLVGLEALLRWQHPELGMVSPARFIPIAEETGLIVPIGRWVLREVARQVTQWWRDGLKVVPVAVNVSVI
QFTQADFAQTVADTVAQTALPFSWLELELTESMLMGQIDDLRRQLGELRQLGVTLAIDDFGTGYSSLSYLHRLPINVLKIDRSFVARLDQDGVERSLITT
IITLGHHLGVQIVAEGVETAGQRQILFDAGCDVFQGYHISRPLPAGVVRG----------
>tr|U4QGT3|U4QGT3_9RHIZ Linear chromosome, complete genome OS=Rhizobium sp. IRBG74 GN=BN877_II1787 PE=4 SV=1
---------------------------------------------------------------------TDENSNPSDRHVLLEAMIDHVPDFIYAKDLE
GRFLFANRAIVKENGFTVEELIGLT---DYDIHGEARRAGI-DTEARV-------LGYEERAMRGDIDRWLMMSRVPLRDKSGNIIGVVGASRDITQKKA
SERLLQTQARAIENLATGLAVFDAATGEPSASPALAPHAGLT----------ALISDP---TA---IPASDGKA---HGFVWCAA---------------
----GAAARMAGL-----DRKRAAEHIAFLADHDMLTQLPNRRFLDTRLPEVLAAAAKARRTIAVCFLDLDNFKQINDTLGHSVGDALLSKTAARIAGSL
GRNDLVLRVGGDEFVVILEKQRDF--ETRLQGIQAAVSQPLRIGSYDIKATSSIGVAFFPEHGETTAEIVAAADLAMYQAKHNGRDGIATFSPRMADDLR
KKVTRIEELRRAVERDEFILHFQPQVDLLTGGISGVEALVRWQHPAEGLLGPAEFIGLAEETGLIVELGESILKKACRQARDWMAAGLSPLKMAVNISPR
QFQ-AGLADQISSVLKETGLAPSLLEIEITETLIIQDVDTSVRIMRAIKQMGVSLALDDFGIGYSCLGMLKTFPLSCMKIDRSFLTHLPAKTKDSAIVSI
MIQLAGSLGIDVIAEGVETAEQADFLRAAGCPYGQGYYFGRPVAAGEIEG----------
>tr|G6XUN5|G6XUN5_RHIRD GGDEF family protein OS=Agrobacterium tumefaciens CCNWGS0286 GN=ATCR1_12213 PE=4 SV=1
---------------------------------------------------------------------MSENANPSDRHALLEAMIDHVPDFIYAKDLE
GRFLFANRAIVTENGFTVEQLIGLT---DYDINGEARRAGI-DTEARV-------LGYEERAMRGDIDRWLMMSRVPLKDEAGNIIGVVGASRDITQKKA
SERLLQAQAHAIENLATGLVVFDAAAGEPSASPALAQEEGLA----------ALVSEP---IA---IPASEGKA---HGFVWCAS---------------
----GAAARMAGL-----DRKRAAEHIAFLADHDMLTRLPNRRFLDTRLPEILAAAAKTHRRVGIGFLDLDNFKQINDTLGHSIGDTLLSKTAERIAKSL
RKNDLVLRVGGDEFVIILEEGRNV--EARLQRIRAAVSQPLRIGNYDIKVTCSIGMAFFPEHGETTAEIVAAADLAMYEAKHNGRDSIATFTPNMADDLR
KKFTRIEELRKAVKRDEFVLHFQPQVDLVSGAISGVEALVRWQHPTEGLLGPAEFIGLAEETGLIVELGESILRKACRQAQAWAAAGLLPVKMAVNISPR
QFQ-GGLVQQIRSVLKETGLAPSLLEIEITETLIIQDVETSVRIMRAIKQMGVSLALDDFGIGYSCLGMLKTFPLSCMKIDRSFLTHLPEKTKDSAIVSI
MIQLAGSLGIDVIAEGVEAGEQAAFLRDAGCPYGQGYYFSRPVPAEVIED----------
>tr|A0A0D8KE53|A0A0D8KE53_9RHIZ Diguanylate cyclase OS=Rhizobium nepotum 39/7 GN=RS75_13905 PE=4 SV=1
---------------------------------------------------------------------TGENAHPSYRHTLLEAMIDHVPDFIYAKDLE
GRFLFANRAIVAENGFTVEELIGLT---DSDIHGDAHLAGI-ETEARV-------LGYEERAMRGDIDRWLMMSRVPLKDKAGNIIGVVGASRDITQKKA
SERLLQAQARAIENLATGLAVFDAAAGEPSTSPALAQHAELA----------ALVSEP---IA---IPASEGKA---HGFVWCAG---------------
----GAAARMAGL-----DRKRATEHIAFLADHDMLTRLPNRRFLDTRLPEILAAAGKHRRKVGIGFLDLDNFKQINDTLGHSIGDALLSQTAERIARSL
GRNDLVLRVGGDEFVIILENQKDF--ENRLQRIRAAVSQPLRLGNYDIKVTCSIGMAFFPEHGETTAEIVAAADLAMYEAKHNGRNGIATFTPRMADDLR
KKFTRIEELRKAVAKDELVLHFQPQVDLLTGRISGVEALVRWQHPAEGLLGPAEFIGLAEETGLIVELGENILKKACRQAQAWVAAGLSPVKMAVNISPR
QFQ-SGLVEQIKSVLKETGLAPSLLEIEITETLIIQDVETSVRIMQAIKEMGVSLALDDFGIGYSCLGMLKTFPLSCLKIDRSFLTHLPEKTKDSAIVSI
MIQLAGSLGIDVVAEGVETREQAAFLRAAGCPYGQGYYFSRPVQAELIEG----------
>tr|F0LDS6|F0LDS6_AGRSH Sensory box/GGDEF family protein OS=Agrobacterium sp. (strain H13-3) GN=AGROH133_09572 PE=4 SV=1
---------------------------------------------------------------------TKSDAPPSDRHALLEAMIDHVPDFIYAKDLE
GRFLFANRAIVTENGFTVEELIGLT---DYDINGDAQRAGI-ETEARV-------LGFEERAMRGDIDRWLMMSRVPLKDKNGAIIGVVGASRDITQKKA
SERLLQAQAHAIENLATGLAVFDAAAGEPSASPALSQHAGVS----------ALISEP---VA---IPASEGNA---HGFVWCAG---------------
----AAAARMAGL-----DRKRAAEHIAFLADHDMLTRLPNRRFLDTRLPEILAASAKAKRHVGIGFLDLDNFKQINDTLGHSVGDALLSKTAERISRSL
GRNDLVLRVGGDEFVIILHKHKDF--ESRLQHIRAAVSQPLRLGNYDIKVTCSIGMAFFPEHGETTAEIVAAADLAMYEAKHSGRDGIATFTPRMSDDLR
KKFTRIEELRKAVERDEFVLHYQPQVDLLTGRISGVEALVRWQHPVEGLLGPAEFIGLAEETGLIVELGESVLKKACLQAQAWCNAGLPPVKMAVNISPR
QFQ-GGLVEQIRSALTQSGLAPSLLEIEITETLIIQDVETSVRIMRVIKEMGVSLALDDFGIGYSCLGMLKTFPLSCMKIDRSFLTHLPEKTKDSAIVSI
MIQLAGSLGIDVIAEGVETGEQAAFLRAAGCPYGQGYYFSRPVQADAIEA----------
>tr|H4FDA9|H4FDA9_9RHIZ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhizobium sp. PDO1-076 GN=PDO_3378 PE=4 SV=1
---------------------------------------------------------------------RVADPNIAGRALWLEAMVNHVPDFMYAKDRD
GRFLYANRAIIEGNDLSVDDIIGLT---DFDLHGEAATDARIEIEQRVM------YEE--RAMRGGGDRWLMMSRVPLRDSSGAIIGIVGSSRDISAHKA
SERLMRAQNRLIEELAEGIRLFPPDNDI----------QTF-----TAQSAPNLRLSP--EAM-----ARLAFENNGFLCFEI-SANGTNHGLIGISSTL
SRSL-GASRMAGI-----DRRQAEEQIRFLVIHDALTGLENRISLEARLPGVLKSAELLSQKVTVGFLDLDNFKQINDTFGHAVGDELLKEVAGRLSRLT
TGHDIVARIGGDEFVLVLHEHNQF--DDRLQRIRATVAQPLTIQGMDFKVSCSIGAAYYPSHGLIASDLFKAADLAMYKAKENGRNAVETFSEELLDSAR
RKFLRAEELRKAIQNDEFVLHFQPQIELTTGLVSGVEALVRWKHPLEGILPPSEFICLAEETGVIVELGEAVLRKACHQAKKWNMNGRRRVPVSVNMSPK
QFQNAGVIDHVKAALSESCLDPSLLEIEITESSIMRDIGSAAGIMKDLTDMGVNFAIDDFGTGYSCLNMLKKLPFSRLKIDRSFITNTPDDEQDCAIVTA
TLNLARGLKLQVVAEGVETIEQARFLHQAGCEHGQGYFYSRPVCDLTIDA----------
>tr|G8AZH2|G8AZH2_AZOBR Plasmid AZOBR_p4 complete genome OS=Azospirillum brasilense Sp245 GN=AZOBR_p440044 PE=4 SV=1
---------------------------------------------------------------------QE----TEEQY---RSIFENAVEGIYQTTVD
GRYLRVNPALSRIYGYRSPADLIDN---LTDIAGQYV-DPG-AFARLMAER----A---RVFRNDGSIIWI---ARCVRDPQGRIRYYEGTVQDITERKQ
H------EEKVFDSVADGILIVDPDLSVQAVNPAYEVMTDFQREALLHRPLVIFAPG------IEDIWRTARTEGRWQGEVTSFRHSGDAFAASLSVTAV
RAPGGALEHYVLTLADISQRKYQEHQIRYQASFDRLTDLPNRWLVCERLEEAIVRAQRMRTKVAVAFLDLNRFKQVNDTLGHHAGDDLLKLVAKRLRNCT
RVSDTVGRLGGDEFLIVAPDAVDAAGARLVEKVLYSMGEPFAV-NQELFCGASIGVAFFPDDGETADQLLRNADLAMYHAKRNPECKFVFYEAGMRERTG
FTLGLESDLRRAATGEEFALHFQPKVDMPFHRVIGAEALIRWHHPVRGLVSPAEFIPLAEETGLIWEIGAWTLREACGRLAGWLAAGLDIASVSVNLSPR
QFQDARLVNFVRDVVERSGVPPERLELELTEGAMIGDIEKAVTILHGLKGIGIRLSIDDFGTGYSSLAYLKRFPINTLKIDRSFVRDIVQSSTDPAIVNT
IVNLADSLGFDTIAEGVETEEQADMLRRQRCTRIQGFLISRPLDVDAFQR----------
>tr|V6T0M8|V6T0M8_9BACI Uncharacterized protein OS=Bacillus sp. 17376 GN=G3A_12230 PE=4 SV=1
---------------------------------------------------------------------EG-HK------KRLKSIFDTLDVAIWSHDLK
TDTLLITSGIEKLYGHSSEEFYDNL---WKKVIHPEDLHILAREDGLSRGEAE--------------VRWI-----PVIDESGNFVDFTSVLFDITDRQE
SEGRYR----LVEMSPDLI-AVYSRGKLDYINEAG-KLFKA--KSPVGQPISMLIPD-KNR------IDEDFEEKLWFEFKAT-QIDGQKIDVEMSAMPY
EGRM----AEQIVGRDLTQRKKAEKTIKYMAYYDVLTGLPNRNMVRKHLNAALSNG---SGKLAVLFLDLDRFKIINDTKGHRVGDLLLKVVATRLKNAV
REQGLVSRQGGDEFIIVLKDFGK-QIIEVAERILNEFNEGITIEGQEFFVTPSIGISMAPADGQDEETLIKHADTAMYLAKDRGKNNYQFYTDKLHGLSS
RKMELENGLRKALEQNQLMLHYQPQVNLETWKIIGVEALVRWVHPEKGIISPAEFIPMAEETGLIVPLGKWVLKKASAQNKVWQEKGYSPIPMSVNISVR
QLQEDRFIDSVKQVLFDTQLAPKYLDFEITESV-MQNSEKTALILDQLKELGITLAIDDFGTGYSSLSLLKHFPIDKIKIDKSFVDDIIHHSNQGAMVKT
IIDMGHNLQFDVIAEGVEEQEQVEFLLKNGCVVGQGYHFSRPLSVEAMEE----------
>tr|U2EJJ6|U2EJJ6_9GAMM Two-component system chemotaxis family CheB-CheR fusion protein OS=Salinisphaera shabanensis E1L3A GN=SSPSH_002957 PE=4 SV=1
---------------------------------------------------------------------TR-HRMRYRELKQLRTAIDASHDMIFVVDRE
SRFLYVNDIACE-LTGNPREAFM--------SSTPDQVLGI-QYDRVIAVGRGMMFVE---------GRWV-----------------VSIVHDITDRKL
AEQSRDRLSRLRASTPEALYQQLCEAAVANVAATLLHVVGVAGPIAVGELVVPLNKSLQGR------WRRIGKRIGLKSAAAVIK-DGTTIGVMLLIADI
ERMV----ALENLE-REAWRRESEKHIEFLATHDALTGLPNRTLFNQSLTMAIEAG----HPFAVMFIDLDRFKFINDSLGHEAGDQLLKTIAKRLRACV
SKSNTVARLGGDEFVVLIKQGEDGDIEAVAGTILDTVLQAVSLNGQEYRVTASIGIAVYPEDARDASSLLKQADMAMYCAKDEGKNNFQFYATELEDRSL
VRMRLEHNLRCALEKQQFELAYQAKISLAEGQIVGVEALLRWHCEELGTVLPGQFLPLAEELGLIVPIGRWVLETACEQNMAWQRAGLPAVRIAVNISAV
QLSDHTLVSHVRSVLERTGMPPHLLELEITETAVMQNIANAVAQLAEIKKLGVMIAIDDFGTGYSSLTQLRDLPVDTLKIDRSFVNELATNTTDQSIARA
IITMGKNLCLNVIAEGVETPEQEAFLRAEACDAMQGFYFSRPGAAEVFAE----------
>tr|Q1JXC9|Q1JXC9_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_0872 PE=4 SV
---------------------------------------------------------------------IKIERQRDEELHFLQSLLDAIPNPVFYKDLD
SG---CNRSYEDLLRKSRQDIIGHR---AADVMPPLRAVV--REDNKVYDSAGMQFD-----------------------QDGELAGLVGTIQDISSLRE
MQSAMQ----LVESTVG-FTGSNCYRRVAQ--LCQ-AIVGRIQEEGSLATIQDGVSFPSEG--------SLVTQMHAEGYVGTRDHNGEVLGVLSVLSRL
ERAKMAARVSAEIEREISRLRDNEDHLEYLVYHDVLTDLPNRQLFRDRLQHAISMASLGQHQVGVLFIDLDHFKKINDSLGHEVGDRLLCEVARRLRLCI
GGLDTVARLSGDEFAIILDQLNNENVILIAQEVNRRLAEMMVVEGYKLFLTASIGISLYPGDGKDVVSLLKCADAAMFKAKELGRDNYRFYTAGLNERAS
ELLALEGALRQAVDKNHLVVYFQPQVELASRRIIGAEALVRWQHPENGMISPVDFIPMAEETGLIVSIGEWVLRQSCLQARQWQVAGYPPMRISVNMSAR
QFRQKDLVPMVRRILQETGLSPEYLDLEITESILMNDVDGAVERLVELHSLGIQLSIDDFGTGYSSLAYLKKFPIQYLKIDRSFVRDVIIDPNDAAIATA
VIDLARNMNLNVIAEGIEQQDQHQFLLDRGCGYGQGYLFSRPIPAHEFEQ----------
>tr|W6KA25|W6KA25_9PROT Chromosome, complete genome OS=Magnetospira sp. QH-2 GN=MGMAQ_1776 PE=4 SV=1
---------------------------------------------------------------------SRH---REQLLADQRLVLENTDVGILHVTH-
GKVRWMNETMAQWMGFSVEELVGQD---VR----AYV-DDE-RVRRQSSRE----EGDSHIRGKNGESFHV---G-KRVNPGDPSKGAIWVVEDISRQRQ
A------VQAVFHNAAEGILLCDIEFRVIAVNPAYSAITGYESEEMMGQGIDRFGAR------LFRMWEVVRQEGRWEGETWGCRKNGEVYPEQRTILAI
HDDDGRLAHYLIMVRDATRQKEDEEKIRFQAYYDTLTGLPNRVLFQERLREALVTATRHDSQVAMMYMDLDQFKVINDSMGHASGDALLVRVSRAILDHL
PDKATLARPGGDEFLVLLPSTDLEA-AETARAIQAAVCRPIDLEDHEVVVTSSIGIAMFPRDGLTAADLIRSADTAAFHAKTQGRNSFQYFLDEMNVVAQ
ERLILENRLRRALSEENFVTYYQPKIDLRSGRITGAEALIRWFGPG-GMITPDKFIPVAEETGMIVDLGRWVLRSTCFQVRSWQKEGLPYFKVAVNLSPL
QLHEGDFVETVKKALEDSGLDPRDLELEITERVIMEQMDEVVRIFSALRDMGIRVTIDDFGTGYSSLSYLQSLPLDGLKIDRSFIADIGEDGQGSSLAGA
VVAIGQSLGLKVTAEGVETEDQLGFLRQQWCDEMQGFYFSRPLPPDEFAS----------
>tr|E7REZ8|E7REZ8_9BACL Sensory box protein OS=Planococcus donghaensis MPA1U2 GN=GPDM_05201 PE=4 SV=1
---------------------------------------------------------------------ESPSSDDLLHQDLFDEIVQQIPISLYVLNG-
SAYSYVNEHFCKLVGYEEKEILGST---LEDLIHPEDFSVIQEYDSKDA---A--RYRVRIYRSDGQLLHV----HSTKKKWQGKNVLFGTVIDITAEVT
ANLKLKEKEELFTYNPDAIFTFDMEGNFQSANPGCEIISGYTTEEILQLSFTPFIVE-NALAS---MIRKDGETRTLL-VTNFMKSGGNIV---------
--------GAYGMAKDITVETEYKKLMEGMGFFDSLTHLPNRTLFEDHVKQAIESKDRNEKDLAVLFLNLDRFKLINDSFGHQFGDEFLKDIAHRLSENI
DANCTVGRFAGDEFAVLLQGLEQQ-VFQLAERFNDVLAKPFEALGHSVSITASIGIAFSSEANESVDRLIKKADSAMNYTKKHKIAQYTVYSEELDQQSA
YRLTIERELKSALTNQEMTLHYQPIIDLKNNRLSAMEALIRWNHPELGFIPPDFFIPISEETGQIVPLGRWVLYTACAQNKAWQDQGHPPIKICVNISTI
QLQQLDFVETVIEILEETGLNAQWLELEVTESILLVDTKLLKSSLHQLKKLGVSMSIDDFGTGFTSLSYLRQFSFDRIKIDRSFVGDISNDLNGKAITAT
IISLAHALNMTVVAEGIEDSTQLTFLQGENCDEGQGYYFGRPLSAELHDL----------
>tr|I4X5T6|I4X5T6_9BACL Signaling protein YkoW OS=Planococcus antarcticus DSM 14505 GN=A1A1_07879 PE=4 SV=1
---------------------------------------------------------------------GQSPSDDSLYEDLFDGMIHQGPVSMYIVSG-
GSYSYVNRHFCELVGYGQSELLGST---PENLIHPEDLPIIQDYDAQNI---A--RYRVRAFRSDGQLRHV----HSTKKQWQGKNVLFGTVIDVTSEVT
ANLQLKENEELFAYNPDAVFTFDIEGNFKTANLGCETLSGYSIAEILQLTFTPMIVQ-NALTE---IIRKDGDRRNML-VTNFMKAGGSII---------
--------GAYGIAKDITAEINYKKLMEELVFFDPLTRLPNRKLFEDRVKQAIEKSGYEKTQPTVLFLNLDRFKFINDSFGHQFGDEFLKDIAQRLLDHV
EQSGTVGRFAGDEFAVLLPDLAPQ-VLDLAERLNEALAKSFEALGHSVSISASIGIAFSIGPEETADGLIKKADAAMYYTKKYKTNQYTIYSEELDQQSA
YRLTIERELKSAITKQEMVLHYQPITDLKSGQLSAMEALIRWNHPELGLVPPDSFIPVSEESGQIVSIGRWVLHTACAQNKAWQNQAYPPIKICVNISTI
QLQQPNFVQTVKAILQETGLSAKWLELEVTESILLVDTDLLKYSLQSLKELGVSMSIDDFGTGYTSLSYLRQFSFDRVKIDRSFIEDISKDLNGKTITAT
IISLAHQLNMTVVAEGIEDKTQLTFLQGAHCDEGQGYYFGRPLPAELHDL----------
>tr|W3ABJ3|W3ABJ3_9BACL Uncharacterized protein OS=Planomicrobium glaciei CHR43 GN=G159_13685 PE=4 SV=1
---------------------------------------------------------------------PSEPEEVRLLAELFGSLVEDATVCMYILNG-
DAFTYFNQAFCIFTGYSKEEIIHEA---LELIIHPEDLQVVKRLHHGAM---S--RYRVRVIRKDGSFIHS----HSKKSSINGEIVMAGAVIDVSEEVA
AALRLKENNELFYSNPDAIFAFDSTGTFTDANPSCEALTGFTIPELLQMSFAPFVLD-EALTN---IYHKNGAHLNLE-ITNFKKQDGAIV---------
--------GAYGIAKDITDKVRYKQQMENLAFYDPLTKMPNRRLFEDRVQQAIELSKISEAKPAVLFLDLDRFKFINDSLGHHVGDEFLKTVSLRLQENL
RKGDTVARIAGDEFAVLLPTVGKE-AERIAARLVAILHEPFEVDGHSVTISASIGIAFAGEPEERAAGLIHKADTAMYFTKKHGSNDYTVYSEELDFKTI
YKVAIEKDLKSAIAKKELCLHYQPIVNLKTGTLAAMEALIRWDNPTLGFVPPDNFIPISEESGEIVHIGKWVLETACRQLKDWQDAGHPPFKVCVNISTI
QLKHPHFVATVQHILKATGLAPRWLELEVTESILMENTEVVKESLQRLKELGVSMSIDDFGTGYTSLSYLRQFAFDRVKIDRSFIGDIEEDLNGKAITSS
IIALAHKLNIGVIAEGIENQDQLGFLEEELCDEGQGYYFSPPKPAAQIDF----------
>tr|A6CIW9|A6CIW9_9BACI Sensory box protein/GGDEF domain protein OS=Bacillus sp. SG-1 GN=BSG1_04515 PE=4 SV=1
---------------------------------------------------------------------EKDHPQSDFARSMFESLIEKAPIGVYILEE-
GSVSYINNYYSDLLGYTREEFTGLS---LQQIIHPEDYPTVQRNQGNKK---E--RYRVRNINKQGKLIYT----QSYMEIICDKRVLFGSVIDITEQIE
AQQMLEESNELFESSPDAMYSMDENGILIDVNPAGEQLIGYSTKEMKGMPFMPLVAE-SAKPS---LIRKDSQKIHVE-ATHYMKVNGEIV---------
--------GTYGTARDITKKKLYDEKMRELAFYDPLTRLPNRKLFEDRLGQIIKLAKIEEKLFSVIFLDLDRFKFINDSMGHHIGDEFLKLVADRLKQSI
RSTDTLSRLAGDEFTILLPDITED-VISIAERINQSLAEPFQVSGHWLSVSASIGIAFSTGKNVGVSEIIHRADTAMYQTKKFRRSQYTIYSDEMEVDTS
YNLIIERDLPLAVINNELELYYQPIMNLESEKVIAMEALIRWHHPELGMVAPNDFIRVAEECGQIIPIGNWVLETACIQNKKWQDSGKPPFKVAVNVSTK
QLQQYDFVDSVKKVLAKSGLEAKWLELEVTESILLDDVEEIKESLTRLRGIGVSISIDDFGTGYTSLSYLRQYPFDTVKIDKSFIDDISRDLHGKRITSA
IISLAHSLNMNVVAEGIEGETELIFLKREKCDAGQGYYFSKPIPVHLLPD----------
>tr|F5LEJ0|F5LEJ0_9BACL PAS domain S-box protein OS=Paenibacillus sp. HGF7 GN=HMPREF9413_0812 PE=4 SV=1
---------------------------------------------------------------------EKGQKELPFYRTLITALIEHAPIGIYMMEN-
GALTYANDSYAKLVGYAAEEIREKG---FLELVHPDDRLLTAESDDRRK---A--PVRIRTRHKDGHWIYT----HPSTALLNEKKVQYGTVIDITEQVL
AQRQLLAYHELFIHSPDAIFSLDEHGRFTSTNPRCESLTGYTKDELIHKPFFTLIDD-DAKSG---IIRKDGEKISVI-VTHFVKMDGFLS---------
--------GTYGIARDTTDQAAAARKMEEFAYADPVTGLPNRKLFEDRLEQTIRFSKDGRLPFAVLSINLNRFKLINDSYGHQLGDDLLVLVTARIQGHL
RLTDTLSRFAADQFTLILPETVQE-VMRLIRSIQGGMREPFVLHGHSVALTVSIGIAFNRGKGESAQDLIRYANMAMDHSKKLRTDAYTVYTEEMDLQIS
YKLQIQRDLETASAKHELELFYQPIMALKTGKLTAMEALIRWNHPRLGYIPPSDFIPVAEECGLILSVGIWVLQTACRQAKKWQASGAAPFKVAVNVSTK
QLQQPFFAEHVLSIMKEVELEPAWLELEITESVLLDDVHAIKECLLKLKEAGICISIDDFGTGYTSLNYLREYPFDKVKIDRAFIEDINRDLNGKRIASA
IISLAHSLHMDVVAEGIENELQYQYLLGENCNEGQGYYFSRPLPADSLTG----------
>tr|H5XSI7|H5XSI7_9FIRM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Desulfosporosinus youngiae DSM 17734 GN=DesyoDRAFT_09
---------------------------------------------------------------------DRVNLERYRLL------ADEVLDIILFISPD
GD---ANEAAVKRYGYTRQ-----E---LTN-M-PV------PEDQVTV---MFEPID-------------GAT------SN-GKPIIISLIRDISQRKI
AEDERVKAEATLESIADAVIATDVQSVIEYMNPVAEALTGWSKAEGSLEKVFNIVNGPEGRAL----INKDGIA-LAIEDSAARDRDNTIIGAVLV----
-------------FRDVSYKRNHMKELTHQAQHDALTGLPNRLLFYEHLKQALAQAKRKQNKLAVMFLDLDRFKLINDTMGHNLGDQLLKNVAGRIRQTV
RGGDTVARQGGDEFLVLLPEINDLEAALVSDRILGVFEQPIIIEDKEVYISTSIGISLYPNDGGDPESLVKQADTAMYYAKEKGRNNCQFFTEGLNIKAN
QRLLTENSLRKALIRKEFILYYQPQVDLKSGKIVGLEALIRWNSVELGLVSPATFINIAEETGLILPIGEWVLRTACAQNKKWQNQGFAPLRMSVNISAR
QFQEPSFIKLVKQILEETNLDPRWLELEITESIAMEKGEPTLEMLNSFKKLGVRISIDDFGTGFSSLNYLSRMPIDTLKIDQSFIQDISKGENGEEVVTA
IIQLAKNLRLKVIAEGVETNTQRTFLEDKLCDEMQGYLFCKAVPSEEAER----------
>tr|A0A099S3B0|A0A099S3B0_9FIRM Diguanylate cyclase OS=Desulfosporosinus sp. HMP52 GN=DP73_16910 PE=4 SV=1
---------------------------------------------------------------------DRANLERYRLL------ADEVPDIIIFISPD
GD---ANEAAVKRYGYTRE-----E---LTN-M-PV------PEDQITV---MFEPID-------------GAT------IN-GKPIIVSMIRDISIRK-
------KIEATLESIGDAVITTDVKAKIEYINPIAETLTGWSNKAAPLETVFHIVHGPEGHAL----INKDGFA-VSIEDSAARDRDDKIIGAVLV----
-------------FRDVSYKWNHMKELAHQAQHDALTGLPNRLLFNEYLKNALARARRKNGKLAVMFLDLDRFKLINDTMGHNMGDLLLKSVAERLRQTL
REGDTVARQGGDEFLILLSEIQDIEAALVSERILGLFSKPIILEDNEIYISTSIGISLYPNDGSDMEGLVKQADTAMYAAKEKGRNNCQFFTQGLNIKAN
QRLSTENSLRKALVREEFVLHYQPQVDLDTGLIVGLEALIRWDSVELGMVSPAAFIPIAEETGLIIPIGEWVLRTACAQNKHWQEQGFSPLRIAVNISAR
QFKEPNFVNLVKNILNETKLDPQWLELEITESIAMEKGQTSLEMLSSFKELGVRISIDDFGTGFSSLNYLSRMPIDTLKIDQTFIRDITTGDNGKEVVTA
IIQLAKNLQLKVIAEGVETDNQFSFLKDKLCDEMQGFLFSKAVSSQEAEK----------
>tr|Q1PY13|Q1PY13_9BACT Uncharacterized protein OS=Candidatus Kuenenia stuttgartiensis GN=kustd2174 PE=4 SV=1
---------------------------------------------------------------------QD-GKQRYKRLV------EILPDIIYRIDAN
GYFTFINEAVQV-FGYEPDELIGKH---FSELIHPDDLKKV-EYSGKTSDYKLIRYME----YTIQIIKWPGHYDSDIMKNDKRFVGTVGVIRDITGSKH
AEE-------AVEQSPAMIAVTDTDGRIDYINPK--KVTGF--EPELGKNLID--------SL---LWKAITSKGEWKEAFSSRKKHGELFWTSLSLS-N
E-------HYLAIMEDITEHKQAEERIHYLAYYDSLTALPNRELFHDRLNMAIIHAHRKQQMLAVAFIDIDRFKKVNDTLGHSTGDRLLKIIADRLKSCI
REEDTVSRQGGDEFVLLLTEISREDANDVTQRILKKLKEPVIIDDHDLCISASIGIALYPGDGTTAEALLKNADSAMYISKESGRDNYHFYSSTVQEKAY
EQLLEEMYLRRALENRELVLYYQPQVNIATGRLVGMEALLRWKHPKKGLISPAEFIPLAEDTGQIVPIDFWVLHTACKQNMAWQRAGLPSVPIAVNISGH
TFGRENLIDFVNNVLHDTRMSPDALDLEITEGIAIQNLQTTIYKLNKLKSLGIQITIDDFGTGFSSLSYLSKFPIQKLKIGMTFIHNLHKDPTNSAIVKA
VIAMAKSLQLTVIAEGVETDEQFEFLQGLQCDEFQGYLCSKAVTSEEMGR----------
>tr|W3AHE0|W3AHE0_9BACL Uncharacterized protein OS=Planomicrobium glaciei CHR43 GN=G159_01705 PE=4 SV=1
---------------------------------------------------------------------GRDITEMLESEQMYQSFFTDHPDGVYSLDKE
GHILDLNKESEKISGYSKEELIGRD---FRMVIAPEVLEEVN---E----------------VLQGVPQWYQIT-TLPATLKGKIIGIHGMLKDVTEKNQ
LEQLRNEQTVAVEKVTN-VIFYEKEHHWLR----------F-----YGPNLPEVFA---IDAS---IAADIEADPSWKACWSMLSTDGTLLGTFGVYSGL
TTF----SYLSGL-----ERSRHEEKIQFLANHDALTNLPNLRYFKEVFSTV----REQTDEIAVMFMDLDQFKSLNDTFGHNFGDILLQVIARRIEKTI
GETNMVARMGGDEFILLIRTITDRQAKEMAQQILKATEQPLMIQGQEFQVTASIGISLFGQHGNTIGQLMKNADVAMYNAKETGGNACKVYETTMDDKAY
ELYMLRGEFRKALEQQQFELHYQPKISLTTGRITGMEALARWRHPEKGNISPAVFIPLAEESGFIQELGNWVIQTACRQVKEWRETEGGEIKVAVNVSVK
QFIKQDVAAFVKATLEEMELPPDCLEIEITESVLSSHESVIQQAVKNLQKLGIKVLIDDFGTGYASMTYLKQFRADAIKIDQSFIRHLPNNQDDAAIVSA
LITLAQALDICIVAEGVETKEQLDFLREKKCCEVQGYYFSKPLPPAQMSK----------
>tr|N1VS33|N1VS33_9LEPT Diguanylate cyclase (GGDEF) domain protein OS=Leptospira terpstrae serovar Hualin str. LT 11-33 = ATCC 700639 GN=LEP1GSC203_299
---------------------------------------------------------------------NEPLGSKILSGLTVKSLLAEYPNSFQVMDWE
GNFISVTERFARFLEFEPKEIAGKS---IVDFTQEDDKENTK-----R-------NFENRLVTKSKEEVWIIWLLIPLR----ESKIILAFDRDVTIQKD
ISFEFLLQQQIFDNLPMGIAITDEKGKIVETNKTA-TYFNIQDGELLNRTL----------KIHKEVIRIKEDKITWFDILATPLEN-------------
-------FGLAVAFLDITQRRHAEEKIAYMAFFDQLTNLPNRNSLIDKLFPIFEEARRHGNLVGVLAIDLDNFKIINDSRGHDFGDKIIKLVAYRIRESI
RVYDLISRQGGDEFTVVLPDLSNRDAAVISESILDAMTHPFVIDGERIFVNISIGIALYPTDGKDSNTLLKNADSALNLAKAQGKNCYVFFTEELQTVVA
ERLEIENRMRIAIIENQFTLMYQPKIDLYTRKPVGVEALIRWRHPERGLISPNVFIPISEETGMILAIGEWVIKSAIQTMRIWKDEGINEVSMAVNISTK
QFKHERLISTIAENLKLFKVDPHDLEVELTESSVMENADAAVRTMQEIRKLGAKIAIDDFGTGYSSLGYLKKLPISSLKIDRSFVSEITTDKDSKTIIHA
VSNLAHNLGLSVVAEGAETAEQVQLLAESGVDLIQGFFFAKPMTSEDCLH----------
>tr|Q2YBD4|Q2YBD4_NITMU Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) GN=N
---------------------------------------------------------------------KKEFELNY-SLSVLKAAIEATVDGLLVTDRR
GC---YNQLYVNMWPIARHQAIGYC---AGQLRDPEQFLRSIIYATL--------------------NVFEVKT------LEGSDIVLVWSFRDITERRQ
GESYKAQ---IVESSNDAIIVKDLNGIITGWNAAAEELFGYRSGEIIGSSILTLIPD-EDRRT---RWGK-GKKSIDVSVTISKDSAGNIIGASKI----
-------------ARDITQRKESQERIEYLAHYDLLTGLPNRALFTDRMRIAIENASRYAFRLALLFVDLDRFKLINDSLGHAIGDKLLKAVAERMQSTV
RQADTVSRLGGDEFVVLLGRIHTTEAARVAEKLIAVLSQPYQIEQHELLLTASVGISIYPDSGKDVNSLMRNADVSMYSAKGQGRNRYQFYSEDLTSGAD
ERLRLEYDLRSALARDEIFPVYQPQLELATGRVVGVEALMRWKHPERGLVSPASFIPVAEDSGLILSLGEHILRESCLQARQWHEQQGFEGTIAVNVSAV
QFRQNDFTDVVLRALADSGLSPECLELELTESVVMHGVESATQKMCFLESRGIKLAIDDFGTGYSSLSYLRQFAIDRLKIDRSFVRDLPQDTDAKAIIRA
TVAMGRSLGLRVMAEGVETEGQAEYLRSVQCDESQGYLYARPMRPDDFEA----------
>tr|K5CBF8|K5CBF8_LEPME Diguanylate cyclase (GGDEF) domain protein OS=Leptospira meyeri serovar Hardjo str. Went 5 GN=LEP1GSC017_1698 PE=4 SV=1
---------------------------------------------------------------------SIAYDKIREKVIVLQNVFEESLDILMQIDPG
TQIINANKQAVVVLEYPLEEIVGKE---FSFFMPPVEVDEDEEFQGNLIE-----PTE-------S---------SFRLFPVNGKMAIWATFRDITERKR
SQEQVKNQKAILDNLDSDIAVLNSNFQYEYTNPVF-DIRKWIFKKT----DEELAAD-EKREIFEELIQDSNDKVTYLLRKYIDDTET------------
-----DQKRIISFGVDITERKLSEERITYLAYYDALTGLSNRTLFIDHANQALKNHKSSESLLAFYFFDIDNFKFINDSLGHTKGDILLQMVGARLKRVM
TEVDTVARFGGDEFAILKVDVPNSAAAEFAQKILDILSQPFHIMGRDLFTTISMGIALSPNDGISSSELLKNSDMAMYKAKELGRNNYKFYTNELILRSE
KRLYIENSLRKAIQNEELVLFFQPKISTVTNQVCGAEALIRWKHPERGWVPPVEFIPVAEDSGIIERIGDWVLEEACQLKKEWKKQNLPAFPVSINVSGK
QLARANWSHRVQSTILQYEINPEEIELELTESSIMENPEKSIEAFEYLSGLGIKVSIDDFGTGYSSLSYLKKINADVLKIDRSFVIDLELNEDDRAICKA
IINMAHSLGMEVIAEGVENLAQRDLLHDLGCHMIQGYLYSKPLPAHDFVE----------
>tr|A0A0D2GGW3|A0A0D2GGW3_9DELT Contig_19, whole genome shotgun sequence OS=Desulfarculus sp. SPR GN=X474_09085 PE=4 SV=1
----------------------------------------------------------------------EGVTSIPSTNSLFQALMGLVGHPISEGAIR
GPCLEANPPACLLLGYNKNELTGMT---NRFIRLPQKPPR-------IPTL----AAE--FVTRNQEIIPVRLSCCLL--SLGTDRELVVMMENSGASLN
TER-----ERAFDRLGVATAVTDHRGLILKTNQAFTQMTGMSPHQAVGSSLNLHSPD------YKHVWEAAARSGSWQDVEHFTGSQN------------
-------AHCLATLKELEGSRLSKNKIIHLAHHDPLTGLPNRVLFYERLKQSVAQAKRRKVQLAVLFLDLDNFKTINDSLGHSVGDKMLKTVGARLLSCM
RAEDTVSRLGGDEFVVVIPEIAEEDAVKVARRIIQMLSRTIIYEGHELTLSASIGLTIFPTDGGDPETLIKNADLAMYQAKKQGKRRFQLFSPAMHTNVT
RRLIMESNLRKGFQNQEFVVMYQPKFDLATGKVGAMEALVRWDRPDLGMVSPAEFIPLAEESGLIVPLGEWVLRQACLTTKELRNQGMEDLVVSINLSTR
QLLQHDLASMLAEILTECELPPSALDLELTESAVMHNVEGAIGTMDDLRQMGISLSLDDFGTGYSSLKYLKRFPIDVLKIDRSFVKGLPDDPSDVAIVIS
IISMARAMGLKVIAEGVETIDQLRFFLHNEVDEVQGFIFSRPLVKSRLAH----------
>tr|D6XWT2|D6XWT2_BACIE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS
---------------------------------------------------------------------------MDLNQWDIKSFANMMSDAIMGVDQE
EVYAFINNTCKKRFGYTIEEG-----------ANPEMVDYLN-YQEV--------IYS------D------ETKLDPVRNSAGDITHIIAVTRNITTIEN
QRQALLRSNQLFDYNKSGIFELDKNGRFISLNPSGTMILGMDEKEMMQNSFHSIVCEP--STVQTAIIDANGDR-KRLDVTHVI----------------
----YEVVGVYGIARDITSEHRQKKQIEDLANQDQLTGMPNRSAMKRKLKEKLRSH-QKDGYVAVLVLDVDDFKLINDSVGHDQGDELILELSKRLDQAF
SKRFDIGRIGGDEFMMIGHPKSR-DLTDISGILDHLFSEPFHIENRNYYLKSSCGITVVNGHQRIPEDVMKQAEMAMYSSKKRGRGLTTFYDESMNEASR
RMLFLEQELQLILQERGLFVHYQPILDARTGQIKSFEALVRWHHRQEGAISPSEFIPVAEESGLIHQVGEFVLDESLSMLTKWRKAGHQDIRISINISVK
QLEDRSLLTMIQQKLDHYGLLPHDIELEITETVVMENIDKVRHTLDLLQDKGIYLSIDDFGTGYSSMSSLNRLPFHTIKIDRSFITDVMYVSKSRAILRS
MIQLASEMGMTTIAEGVETKEQFDILRTEGVSEVQGFYFTKPVTACEAEE----------
>tr|A0A0B1TX00|A0A0B1TX00_9DELT Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Desulfovibrio sp. TomC GN=NY78_2965 PE=4 
---------------------------------------------------------------------NNHQKSLSESEERFKTIFDSVSDCIFIHDPN
GKIIDVNARTCATFGYSREEFLKLD---VGKIS-S----------------G---SFEWQCKTRNGRIFWG----STSRAVINGIDQVLVSLQDITERKQ
TEIVLAEERKVLESVPGLLYLYNDEGLLVRWNKQHESITGYSGQELSQMHLLDWYKDK-N-AV-----------------EEAQTKNGEKIPFYLTAV--
----EGKIYFVGVGIDITEQKKLEQQLTFRALHDPLTGLANRTLYIERISQANERLENKEHNFAVVFIDIDSFKSINDSFGHEAGDLVLCEVAHRIECCA
RKTDTVCRYGGDEFILLLTDIDRE-VIQVIGKVQDVLVAPLAINSHELQISASFGVAYGNDGQQSPETFLRNANIALHNAKISRIEKLVVYEEGMHEAAI
LNLNLQNDMRRGLEAKEFFVVYQPIFVLKNGQLSGFEALLRWRHPHRGIISPGEFIPAAEESGFIYELGKFVLNQSCLDFVGLMPNLPDSLTLSVNISPR
QLARPGLTDMIEQALCKTGLPPWALILEVTESSIMEHPEDSACILDKLKQKGVHIAIDDFGTGYSSMSVLQKLPLDSLKVDMSFVSRLTGSKGDREIVRA
IITLAHSLRLKTVAEGIETVEQLEILRELGCELGQGYLCSRPLSLVDIPL----------
>tr|K2C6U5|K2C6U5_9BACT Sensory box protein OS=uncultured bacterium GN=ACD_42C00522G0006 PE=4 SV=1
---------------------------------------------------------------------QKRTQELEKALSVTRATLESTADAILIIDKN
GKLVDFNQKLLEITEVGEENAWTYL---LSLLKDP---KELI-MRYLMMH--D-----------MGD------Y-SQPHRIGNEIVGRVWSFRDVTEKRK
QEESLRLTKR---ASTHGIIENNSQLTIMYLNPASAHLLNLNETKIVQHSFLTLFPD----IS---LQCKINDNLLWLTIDIDYDKDQ------------
----AGISHFVCIINNITKSKELENILHYKAVHDALTGLPNKAYLEDAIRYRIKKALIHHKNFGLLFIDIDRFKNINDTLGHHIGDELLCLFGKRIQNIL
QKQDIISRISGDEFIILIHSVSDKKMSGVANRILKATRKKFSYADHEFNITISIGVVHYSDCGNNPETLIRNADIAMYQAKHNGRNQLCLYTKSLNNTIS
RRMKIENELHNAIQHNEFELHYQPIYNIIENKFDKVEALLRWKNKELGQVSPTEFIPIIEDIGMMTSIGRWVIETAIRQVRLWRKNNIADVAVTINVSAK
QLLDMHFVDHINHVIYRDSVLSKKIILEVTESFFLLE-EKVATTLNELNNLGIKIAIDDFGTGYSNLSYLNQFHISYLKIDKSFVDQIEQPHFNDSVLLA
IVAIAKRMKFRIVAEGVETKKQYQFLKLNECDEIQGYYFSKPLSATAFEE----------
>tr|F9ZFI9|F9ZFI9_9PROT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Nitrosomonas sp. AL212 GN=NAL212_0894 PE=4 SV=1
----------------------------------------------------------------------NAHRDLMNSELRLRLA-LTAANLWDLNVQT
G-EVLVNPEYALMLGYAPDTFVETNSSW-RERLHPDDQERVGRIYQEISGLRDDYQVEFRQLTQQGTWKWILSHGKLVYDDQNRPLRMLGIHTDIEERKT
REIALKRSEHLLAAMNIGILFEDNERRVEYVNPAFLRLTGLPTKTVLERSTERFAQPTHASKFVLNILHTHEISERFELELSDGRLTQLSYPV-------
TDTEERILGRLWIYEDITQERQTAQQLLYLAERDPLTGLYNRHRFQEQLESLIANCLRSRGKFALLYFDLDDFKYINDTYGHSAGDTVLVRAAGEISSII
RQIEIFARLGGDEFAILSSIQPDEDINVLPSRIITAISIPLRFHGRNIRLTSSLGVAIFPEHGETTEDLIAHADTAMYQAKTQGKNTWAIYDSTRDDVML
QRMTWRSRIAQALEHDLFELHFQGVYLTSDKMLSHIEALIRMRDLERHLIMPGQFIPIAEKSGQILDIDRWVVKECIEKLAN----DLNMPPLAINISGR
TFDEPSLPLYIRKLLLERGVEPGRLIIELTETAAVSDIQDAQRFIESIHQSGCKVCLDDFGSGFSTFGYLKYLGVEILKIDGLFISDLHNNRDNQVFVKA
MVDVAHGLGKITVAEYVEDEDTFRMVKKLGIDLVQGYNFGRPSKILPK------------
>tr|I3I7Z7|I3I7Z7_9GAMM Sensory box protein OS=Cellvibrio sp. BR GN=O59_003263 PE=4 SV=1
----------------------------------------------------------------------HSYQQLAQSDLHQEQQQRAQLRHWQWNPHT
GNYQF-SESMSKLFGLPAEALSGKMEDFINSALDQQ------------------Q----RLEPGGNQRFWLQLQADK---PTTEGIVLQGTMQDISERKR
LDLALTAAA--------------------------------PCADVMDENLCFVSSAATAHYPLDEMFREHKIE-SYLGV---GIRDAEGIPIGILIAMA
EHPTPQLSSLLERIGGELRRAQDQEKIYNLAFFDPLTRLPNRRMLQDRLKLVVSQSTRSQQYGALLFIDLDHFKLLNDTRGHHIGDQLLVQVAERIESII
RSSDLAARLGGDEFVVVFDNLGDNPAKKRAEHLHELVSLPYALRQSVYHCTISIGVSLFNGQNRSIDDLLRHADAAMYQAKDSGRNAIRFFDPNMQSHLE
KRAAIEEDLRSAHDRKQLIPYYQVQVDEQ-GKAIGVELLLRWQHPQKGMISPADFIPVAEQTGLIVSMGREVIRQACQQLQRWQQRAEAHLSIAVNVSPI
QFNQPNFVEEVLTIVDSCGVNPRRLKLELTESSLLKNVDQSIVKMQLLQDRGIGFSMDDFGIGYSSLSYLKRLPLDQLKIDQTFVRDIAIDPNDAIIART
IIAMAQNMNLQVIAEGVETDQQQVFLEQNGCRLFQGYFFGRPMPLEQL------------
>tr|I4B1B1|I4B1B1_TURPD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Turneriella parva (strain ATCC BAA-1111 / DSM 21527 / NCTC 1139
----------------------------------------------------------------------NSLLGLTQAHERLE--LGSLA-AWDLDVMT
GEMQL-SREARRIAEL-----PP---------------EPMHF------------DTEFAMVTHTGRKIWVRSQANP-KE-NGRIVRLVG-MHDLTEKRE
KELALKKSERLVESASDGIIVHVGGFIAYANDAALRLVGAKNAEEIIGRNALEFVAPEYRQMVIERMKIVN-APGGRAPAIKFMRLDGSTIDVEVSATGT
RFNDS--NATMVVVRDISERKNAEEQIRYLGQHDLLTGLPNRALFADRLTQTISFAAAHKKSFALLFLDLDHFKKINDSHGHQIGDRFLRQVSGRLLECV
GPLDTASRQGGDEFSIIIAELEHADAAFMARRICEALSEPFQVEALRLHASASVGIAMYPKDGLQAEVLLRNADIAMYHAKGSGRNQFQFFSEELNRTTH
ERLEIEAAIDDALEKNEFEVYYQPQLNLATGKIESCEALIRWNHAKKGLLAPGEFISVAEESGHIDAIGRWVLRRVAADFAEFSAAGFSNMRLAVNVSSP
QMRVIDFAAFVAAVVAEHKIPAGCLELEVTESMLMSDTEQAIATISSLTAQGVRFSIDDFGTGYSSLSYLRSLKIHHLKIDRSFVADVISDPDDATIVRA
IISLAHSLRLTAIAEGVESEQQLQFLKDEGCDMVQGYLLARPMPLADC------------
>tr|G3J0G4|G3J0G4_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_3835 PE=4 SV=1
----------------------------------------------------------------------RAEQTLTASEGYQR--ANATPM--LISDKR
GIITQVNRQAELMLGYKLGELVGQSIEVL-------------------------A----ARPLGVGRTV-------------------------------
--------------SNEPMVITDADNIILQVNRAFTESTGYSKEEAVGQKISLLKSGRHGAAFYAAMWETIKSTGTWQGEIWDRRKNGEIYPKWLIISVV
KGDDGAITHYVGTHIDITERKAAEEQIKQLAFFDPLTQLPNRRLLQERLKHGIDVERRDGKQLALLMLDLDRFKSVNDSLGHLAGDELLQQVAARITARL
RDVDMVARLGGDEFIVLLEDIAHPEAARVAEEIIADLSKPFWVEQEDIQISASIGISLYPQHGDNPALLMDNADAALYQAKDAGRGCFAYFSEDLTLAAR
ERIALESRLRRAIEQQDLRVFYQPQVDIISGRIIGAEALVRWQDSVEGLIPPIRFIPIAEETGLILVIGEWVLRETCRQGRQWLDAGL-PLTLAVNVSPH
QFRRSDICDLVATVLSDTGFPASQLELEITESGLMDNQGNATEILNCLRGQGIRLAIDDFGTGYSSLACLKHFPLDLLKIDKSFIDDIPHLQDDMEIAST
IIAMGHILGFKVLAEGVETPEQLMFLQEKGCDMYQGYIKSCPVPAEEF------------
>tr|D5CRP6|D5CRP6_SIDLE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sideroxydans lithotrophicus (strain ES-1) GN=Slit_1395 PE=4 SV=
----------------------------------------------------------------------RSEHALKLSEDN----LRAQSGIGSWHLD-
---IVNNCLQWSDE-------------------------T------------------------EGTP--------------------------------
-------------SSGEAILITDENVRVVAVNHSFVAMSGYRSEEVMGKNPRMLSSGRHDAEFYRAMWDDINQHGYWQGEIWDKHKSGRIYPKWMSITAV
RDEHGKVVNYISIARDTTEQTEAEKNIHFLAYYDVLTGLPNRTLLRDRLGQMIAVAHRDKHQFSLIFLDLDRFKYINDSMGHSVGDRLLQSVALRIQDCV
REGDTVARLGGDEFIVLLREAGESA-SVVAQKLLIALATPYDLDGQVISTQASIGISIYPDQAQDADTLIKNADMAMYRAKEEGRNNFQFFVPEMNFRVD
LLFSMEKDLRLALERGELFLQYQPQADLASGTLSGVEALIRWDHPVKGQVSPAEFIPVAEETGQIVAIGEWVLRTACSQMAEWRKTGMHDLTIAVNLSIR
QLRQPDLAELIKSVLLETGLDARHLELEITEGIMMGDNQAAFRFLSEMQDLGVQLSIDDFGTGFSSLNYLKQMPVNKLKIDQSFIRDIETDEGDAAIIRS
IISLGHRLNLRVIAEGVETQEQLDFLRIRGCDEIQGYFYSRPLLAEDF------------
>tr|D7DLY0|D7DLY0_METV0 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylotenera versatilis (strain 301) GN=M301_2309 PE=4
----------------------------------------------------------------------STESLLLQKNTLFN--KQRVP---------
----------------------GV----IQFRLY---PDRSCFPFRL--------GESQPEKMEDGSILWHGFIT------------------DITERKQ
ADDRIKRLSA---TSSEGILITDANNSIIAINPAFTKITGYNLDEVIGRNPRMLSSGRHDATFFKKMWHEINTTGQWQGDIWDRRKNDEIYPKRLMINTV
YNEDGAVQRRIAMFTDITQKTEAEQLIWKQANFDFLTGLPNRQMFHDRLNQEIKKTNRNNLQLALLFIDLDRFKEINDNFGHDVGDAMLKEAAIRLNKCV
RETDTLSRLGGDEFTVILGQLNDLSIERAVQDILNKMTEAFYLGDEVVYISASVGIALYPDDASTNETLLTSADQAMYAAKQLGRNRYHYFTQAMQKSTQ
KRMRLTNELRGAQEAGQLRLYYQPIIELANNSIHKAEALIRWQHPTRGQISPAEFIPIAEETGLINSIGEWVFHEAVKQASHWRATYHSEFQISINKSPV
QFRDD-TLKAWPDQLKEIGLSGQSIVVEITEGMLMDASDLITSKLLAFRDAGVQVALDDFGTGYSSLSYLKKFDIDYLKIDQSFTRNLSPTSADMALCEA
IIVMAHKLGIKVIAEGVETIEQRDLLIAADCDYAQGYLFSRPVPPDEF------------
>tr|F9ZWU4|F9ZWU4_METMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomonas methanica (strain MC09) GN=Metme_3748 PE=4 SV=1
----------------------------------------------------------------------EAHAKLSASEHRLQ--ADASPY--ALNDDQ
QNITLLNPAFTATFGYTKADIPSLADWWPRERLRQAKKTRPFQPFEQAF-YQQDDNEEEQRTLPSGEVVWLSTFKLP-RNSENQIIGVVGAYEDISMRKR
IEDQLLWRTT---NSSEAMMVVDARNKVLNVNAAFTAITGFSRDDVLNKDLSILIGEEHDAELYQAMRQSIEATGNWRGVIKNRRDNGEHYIVEIVINTI
FDNEGRPSRRVAFFSDITQRKRSEEEVWQQANFDQLTGLPNRHLAGRQLGEDIKQAQRAEQRLGLLMLDLDRFSVVNDTLGHEIGDELLQQVSRRLTSSV
RESDMVARLGGDEFLIILNGLDSTEPEHVAKKLVEQLSQPFVLQNEQMYVSVSIGVTLYPDDGLESSQLLRNADQAMYAAKAKGRNCYSFFTPSMQAELN
ARAAMVNDLRGALARQEFTLVYQPIVELATQRVRKAEALLRWRHPLRGLVSPGDFVPVAEQSGLINEIGDWVFHTAVAQVSHWRKTLHPDFQISINKSPK
QFLDV-RHNDWIRYLQTHDALGQSLVVEITESLLLETNAKTAEHLLVFRDAGIQVAIDDFGTGYSSLSYLKKFDIDYLKIDQSFVRNLSPESSDFVLCEA
IIVMAHKLGLKVIAEGVETQMQCDLLTAIGCDFGQGYLFSKPVAAESF------------
>tr|D5CRW8|D5CRW8_SIDLE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sideroxydans lithotrophicus (strain ES-1) GN=Slit_1467 PE=4 SV=
----------------------------------------------------------------------RDGDALRESESRLH--ADHAPI--WLVGKD
GRYQFVNKRFCDATGI-----------------------------DQC--LSQDEVSVETLPLVDGKLHQLEVTKAQ-RDSNGEVIGAIGISVDVTGRNQ
AEEALRESE-------------------EDISRLLSRISDFFH---------------SKADRFSAEYRVRCKDDSWKW------------ILTRGMVAH
RSTDGRVTRMIGTHTDLSERKLAEETIRRQANYDSLTQLPNRRLFRDRLEQTIRLAKRDQSSFALMLIDLDHFKEVNDTMGHDAGDFLLVDAAQRIQHCV
RESDTVARMGGDEFVVILPDVNDPDIERIAQNIITKLAAPFVLGEEKAFISASIGITLYPSDADSMETLLKNADQAMYVAKHLGRNRMSYFTPVLQENAQ
KRMRLVNDLRDALSSNQLRVFYQPIVELATGDIHKAEALIRWLHPTRGMVSPSEFIPLAEETGMIIEIGDWVLRQAMHQVKRLQASHHKGFQISVNKSPV
QFHNDNPLKEWLGELEQNGLLASSLVVEITEGVLLDDDGNVKDRLLASRDAGIQVAIDDFGTGYSSLAYLKKFDIDYLKIDQTFVNNLGNQSDDMALCEA
IIVMAHKLGLKVIAEGVETEQQRDLLKQAGCDYAQGFLFSKAIPAEEL------------
>tr|Q1H367|Q1H367_METFK Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Methylobacillus flagellatus (strain KT / 
----------------------------------------------------------------------QADERLRQQLGLYN--ANAQSGEGVMVIED
GKIIYANEAVRKIGGYDARDISMGSSFLSKQRIRGEYTPR-----------------------KLGKPIPIEVAAAN-RDGSE---RIVVLIIDISSRKQ
AEEALLQSRK---NTSEAILIADRDRNILEVNQAYLDMTGYGREDCVGTYLALLDEPAGGGQL---IGNLVQQHGKWMGELLAQKRSGEYYPAWVSISTV
HDNHGSLQNYVVVLTDISQRKQAEERLQFLATHDGLTGLPNRTLLQERMELAVLRAQRYQQCVGVLFIDLDRFKIINDTLGHQAGDVLLQEVAGRLGECL
RQTDTIARQGGDEFVVLVEDFIEQQLVNVARKIMHALAQPFILMQQELYISASIGISVYPDDGVDISSLLKNADMAMYRAKDDGKNTFHFYSADGNANSV
SRLTLENSLRRALERNEFSLLYQAKLDLAEQNIIGAEALIRWHSAELGMVSPQDFIPVAEETGMIIEIGEWVLQQACRDACHWQEVAGRPIRVGVNISAR
QFREDSLYQAISNALEESGLTPNCLELEITESMIMQNAERASQMLQHFRNLGSYVLIDDFGTGYSSLGYLKHFPIDSLKIDRSFVRDIPQDSDDMAITQA
IIAMAHSLKINVVAEGVETQAQLEFLRGQGCDQLQGYIFSRPLVVEDF------------
>tr|C6X6V4|C6X6V4_METGS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylovorus glucosetrophus (strain SIP3-4) GN=Msip34_1854 PE=4
----------------------------------------------------------------------RSEARLKEQLDTYD--AHAQANEGVAIIHR
GKIVYGNDALWRIGGYSPGDIPLGSDFFSQQRLQDMDVPR-----------------------KNGRAIHIEIAAAQ-RDDSQ---RIVTLIIDISSRKK
AEAELVKSQE---NTAEGIVITDPAFRVLEVNQAYQQITGYDKEEIIGKLPSVMQAGLHEAAYYEGIWQTLRREGQWVGEIWNRRKSGESYPEWLSISQV
ADAKGSVQNYVAVFTDITQRKLSEERLQFLANHDALTHLPNRALLQERIDQALFRAQRNKTAIAVLFIDLDRFKIINDTLGHQTGDMLLQEAAKRLKECL
RETDTVARQGGDEFVVLVEDCGDTDLNTIARKIMATLAQPFILVGRELFISASIGISVYPDDGLDTASLLKHADAAMYRAKESGKNTFRFYAAEANTNSV
ELLTLENNLRRAVERNEFVLHYQPKVDLRSQKIIGAEAVVRWQHPELGMLSPMQFIPLAEETGLIIDIGAWIMRESCRQAVEWQQLTGQNVRVAVNLSAR
QFRDETLRQTIADALTESGLTPDCLELEITESMIMHNAERAREVLQHFHDLGAHVLIDDFGTGYSSFGYLKHFPIDSLKIDRSFVRDIPDDVDDMAITQA
IIAMAHSLQIKVVAEGVETQEQLAFLKKQGCDQIQGFLFSEPLHSHDF------------
>tr|B9Z1R5|B9Z1R5_9NEIS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudogulbenkiania ferrooxidans 2002 GN=FuraDRAFT_1300 PE=4 SV=
----------------------------------------------------------------------RRIRQLQDSLARFE--ARNSPM--SLKDLE
GRYLLVNRAYSRALGKAPAELIGKKSADFESRQY-----------------------EQTL-TLDGLPGDFLVTKFP-FDADGLPAGIGCIATDITQNKR
ERQAKQEAEA---NAAEGILITGADYRIIAVNQAFTRITGYPPELVIGRVSRIFRDN---TSWSVAMLDGLARHGHWQGEMLDRRRSHEWYPAELSISAV
RDDAGAITNYVGVFADITVRKQAEERLQFLANHDPLTRLPNRSWLIACLEDRIQQIASSGQQVAVMFLDLDRFKLINDSFGHQTGDELLRETASRLEQVV
GGRGQIARLGGDEFTLLVSHFASQALSTLAEDILAVLAQPLWLEGQELIVTGSLGISVYPHDGSDARTLLKNADVAMYRAKEAGKNTYQFFAAEMNAQAI
ERLQLERGLRQALERGEFELHFQPIVAAATYRLEALEVLLRWRHPELGLVSPVRFIPLAEETGLIRPIGDWVIRQACRQLAEWDCLGLHVPRLAINLSAR
QFEQQGLIMQVAGALAEAGIAAGRLELEMTESMVMQNPSEAVSLLGELKALGVRLSIDDFGTGYSSLSYLKRFPLDTLKIDRSFIEGLPGDGDNAAIAEA
ILAMARKLSFSVVAEGVETEAQAAFLCAKGCQLLQGYLFSRPLPAAEL------------
>tr|H2CKM1|H2CKM1_9LEPT Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Leptonema illini DSM 21528 GN=Lepil_0369 PE=4 SV=1
----------------------------------------------------------------------LLLKQQIEQDTLFR--LERTRY-RARRGSN
AGLEFMSPSVTEFLGYTPSDFTSNPALLIRIRSSSE-------------------EAEFRIFDRKGHLHWAELRQVT-KDEQGNTVAVEGVVRDITDRKQ
ASNRILHLNS----AGEGSGYTDGLT--ITIDGSVTGLGPSGRAWATGK--TVLTSNVTSDP-----------------AFWKDRAARFGIHSSLAIPLV
HEEIGEVA---GDIAYSLYNIEREAEIEKLAYYDPLTDLANRRLLLDHLEHEMAFLRRRNRFGALLYLDLDNFKHVNDSYGHDTGDEILREVARRLRARL
REEDTVARLGGDEFVILLFDLADSPAQSVAEQVQLTLQPPCIVGQNTFNLTPSIGVTVLPRYDQSPQDVIREADTAMYRTKMEGRNGYRFFHPEMQRMAE
FRLSMEQELHRAIQGQEFTLHYQPQVDTEG-RTVGLEALLRWQHPTMGTLGPDKYIGIAEETGLIVPLGRQILRMACGQLQIWKAQGF-QGTMAVNISAR
QFRDPYFVKDVQDALAETGVDPGSLLLEITESVFLDNLEESIEKMEDLCATGIRFSVDDFGTGYSSLTYLKRLPLYEIKIDRSFTRDAVSNDFSRAIIRT
IVTIAEHLQMTVIAEGVETDDQQKTLIELGCRRFQGYYTGRPVPADQI------------
>tr|A0A098G5E9|A0A098G5E9_9GAMM Sensory box/GGDEF domain-containing protein (Modular protein) OS=Legionella fallonii LLAP-10 GN=LFA_1808 PE=4 SV=1
----------------------------------------------------------------------AFEKQYH-----LKLVDSVHDYIV-----S
------QKETIFPTGYNLSSNPDFVKNLN-FNVG---SD-PVFILPSIF-MNQEY------------QIWLSLTETLFCVLYGQRYLIQYI---------
-----QTEK-LLNAAGEGILWIDTEYNITFINPAAEKLLGYSSDELKNESINSILDEKIVKVPFCSIYHAIQEKTIKAKEVWKKD--HSC--FWVEYTCI
-EVKG----AAVIFSDITERLENEIKLMNMAHFDPLTKLPNRLSFFEYLEHALARAHRNKAQFAVCFLDVDNFKYINDSYGHVYGDQILIALPKIITPHL
RDTDYFARLGGDEFGLIIEDTHKLNMAKIFERIIATFDAPIKVEDQYIKTAISIGVALYPENGCDSEALFKNADIAMYHAKKMGKSTFSFFCEKANEEVL
KVHHIESALLDAINQKRYQVYYQPIMNTINNKILGVEARIRWSDEVLKEFSQEDSLLIAEDKGFIYELGKLILEQAFKEFHSIAKSEA-DIYLAINISRK
QIENLAFTQLIQSLVKRYEIDPKQIYFEISEISLIHDSERTINIMTELNTLGIEFALDDFGIGYSSIHLLKKLPISFIKIDQSFVRDLEHNVDDAVFIQT
TIQLSSALSIKTIADGVENHNQICLLNKWGCTMIQGNYFASPMLLADL------------
>tr|V5C1L9|V5C1L9_9GAMM Putative diguanylate cyclase OS=Methyloglobulus morosus KoM1 GN=MGMO_7c00230 PE=4 SV=1
----------------------------------------------------------------------GYR-FNRQI---FETRQP------------
---------------VNFYSIPKL----LSIALLG----KQHYLIPKIF-LSENY-----------SPWQLLIGGMF-TGVTGHTEFVADVDKRTQELKR
SNIKLAAREK----SQQGIMITDKEAKILRVNKAFTQITGFSAVQVIGDNPRILKSGRHDQAFFEDYWRQLLTNDKFEGEIWNRRKNGEVYPEWQTVTAV
RNNQGEVSHYVSVFSDITEKKDAENKIHNMAFYDPLTNLPNRRLLLDRFDHEIAIAKRYKQFGSVLYLDLDHFKILNDSQGHLVGDELLIQVAARLSEVL
REEDTPARLGGDEFVVLLHANSESLAMTVAEKIREQINAPFVLGQYQHQIGTSIGIALFPGDQESPDGVLQQADTAMYRSKSSGRNAINFFQPSMQEAAD
LRLSLEQDLRGAIDKGRFILCYHPQMDIKG-EIVGAEALIRWEDSLKGRLSPADFIPVAEESNLILTIGKWVLMEACNQIKMWQDDGLVLPYVSINVSSR
QFRQQDFVDQVKYALESTGIAPSRLGIELTESVMIVDTNDTVDKMKALKALGVSIAVDDFGTGYSSLVYLKQLPLDVLKIDRGFVRDILSDSSDAVIVET
IISMAKHLNIKVIAEGVETLEQLVFLKEKGCTIFQGYYFDEPLTAANF------------
>tr|G4T2H2|G4T2H2_META2 Putative GGDEF/EAL-domain containing protein OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20
----------------------------------------------------------------------RDG-FESSQNEGFEIRESAGSYVTFLEPLD
G--------NEKALGYDILVNPIA----SKLKLVQDGHAKSGIVIPSQF-FHSHL-----------SVWWLLLGGFS-TGLSGRTLRMEEVKNRTLELKR
SNASLA--------THEGILITDSSGNILRVNHAFSEITGFSADEVMGRNPRILQSDRHNDYFYDELWQYLLRVGKFEGEIWNRRKNGENVPTWQTITAV
KNEQGDTTHFVAIFYDITEKKKAESEIHDLAFYDPLTTLANRRLLVNQLSNELAVSKRQGTFGSIIFLDLDRFKVLNDSLGHHVGDELLIQVANRLKDSL
REEDIPSRLGGDEFVILIHANKRSLALHVAEKIRRALNRTYFFDDFEHHCSPSIGIALFPDSGQTASQILQQADKAMYQSKTKGRNTISFFHQSIQEAAD
ARMFLEKELRSAIENQDFILYYQPQTDRFG-RLSGSEALIRWEHGQKGLIAPDQFIPVAEEAGLIVPLGIWVFRESCAQMRKWLDNGL-IQHISINVSSK
QFRQQDFVDQIAEAIRQYEVPASRFVIELTEGVVIDNIDDTVKKMRALKHLGVKISIDDFGTGYSSLTYLKQLPLDELKIDKSFVRDITTDFNDAIIIET
IINMAHNLGIDVIAEGVETEAQKDFLYNKGCRVFQGYYFSRPMTSADF------------
>tr|F9ZZJ6|F9ZZJ6_METMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Methylomonas methanica (strain MC09) GN=Metme_4036 PE
----------------------------------------------------------------------RAN-WEARHAA--VIRQPAKPYVTFVVPAS
G--------NEAALGYDISSNPQI----APIQLIQDN-VRPGVVVPANF-FSQQQ-----------RFNWLILGGFL-CGLTGRTARVEEVEKRTQDLLS
SNAALNQE------SHEAIVVTDAEGNILRVNRAFSDITGYSAEEAIGQNPRILASGYHDQAFYREMYRQLTKNNQWKGEIWNRRKNGTVFPELLTVTGV
RDQQNSLIHYVAIFSDVSDKKAAEQEIHNLAYYDPLTNLPNRRLLLDRLQQEIAAAKRHSRFGALFFLDLDHFKNLNDSRGHQVGDELLIQVAQRLHSII
RQEDTACRLGGDEFIIMVPGRFLSLAAMLAEKILLAINQPFVVQGSEHHFSTSIGVTLYPETAEQPEDIIQQADTAMYRAKESGRNGISFFKPAMQVAAD
RRLTLEKEMRLALQDRQFVLHYQPQVNDQL-RVVSAEALIRWIHPEKGMISPAEFIPLAEDTHLILPIGAWVLHEACQQIKAWDAQGN-IDHIAVNVSSR
QFRQAGFVQQVRQALLDAGVNAKRLVIELTEGCVIEHIDDTIAKMHALQAMGVRISIDDFGVGYSSLSYLKSLPLSQLKIDQSFVRHIN-DPNAAVIVET
IIMMTKSLGLNVIAEGVEDESQVEFLKAKGCLFYQGYYFGRPVVADEF------------
>tr|A0A0B0HBA4|A0A0B0HBA4_SOVGS PAS S-box/diguanylate cyclase domain-containing protein OS=Solemya velum gill symbiont GN=JV46_20220 PE=4 SV=1
----------------------------------------------------------------------QVEHTLKESEEKLR--GNLSPI--ALTDMK
GHFLEFNDSFLRICGYTSEEVKALDYWAL-------------------------E----YGPYEKE----------------------------------
--------------SQVGIMVTDANGVILRINRAFSEDSGYTEEELVGQTPRLLKSGHHDENFYAEMWNSIRHTGVWQGEIWDRRKNGEVYPKWMTITSL
KGEDGVVTHYVSTQIDITERKTAEDEIRSLAFYDPLTQLPNRRLLLDRLQQALASSDRDHGQGALLFIDLDNFKLLNDTLGHDKGDVLLQQVAQRLSSAI
RERDTVARLGGDEFVIMLLNVNTQFVEIIGEKILNLLNQPFLLDSHEFQSTASIGITLFGTNDETIDNLLKQADLAMYQAKEAGRNTLRFFDPEMQVVVD
AHMSLVKELRRAIRKDQLVLHYQPQVDSDS-NCMGAEALVRWKHPKQGIIFPDEFIPAAEELGLITELGKWVLESACKQLAAWSTKPFNHLCLAVNVSIQ
QLRQQDFVEQVQSILDRTGADPTKLKLEITESSLLIDTEDVIAKMMMLKSKGIGFALDDFGTGYSSLTYLKSLPLEKLKIDRSFVLDVMTDPNDASIVKT
IVALAQSLDLAVIAEGVETEEQREFLARAGCHDYQGYLYSQPIPPDKF------------
>tr|W0DPJ7|W0DPJ7_9GAMM Diguanylate cyclase OS=Thioalkalivibrio thiocyanoxidans ARh 4 GN=THITH_12390 PE=4 SV=1
----------------------------------------------------------------------RADLASQ-SIPGYRILDPAAEYIL------
--HVEPLEGNRDVLGLNPASFSPAREAIDPFELTQERQA-RGVVVADAF-LRERR------------VAYATLTIGLVTGLSGQTRRIGTVEQRTAELAR
TTRHLREQQR--------------------------------------------------------------TAGAI--EL--DC--VLRHPGAASVVHV
VWKDGRLQRLLGTAQDVTAARRAEQDIQRLAHYDSMTGLPNRNLWRMRARSALQVAQRHGDCMAVLFLDLDQFKTVNDSLGHRVGDGLLAVVGRRLQSCM
REEDLLARLGGDEFVALLPRLPRSDAGTVARKMLDVLARPMVVDGHELTLSASIGIAVYPADGTDVDTLLQHADTAMYSAKDAGRNTFQFFVHEMNVRVL
RRLQLESGLRRALDRDEFTLHYQPQVDAETRALVGVEALLRWQHPERGPMLPGEFIPVAEESGLIIPIGDWVMRSAFAQQAHWRERGRQQLSVAVNISAL
QFARPDFTDRVAQVIAETGADPRRIVLEITESALMDHSPSLTQRLQDLTGMGLTLALDDFGTGYSSLAYLKRLPLDRLKLDRSFVRDLPDDPDDVAIALA
AISVARDLGMQVIAEGVETQGQREFLIAHGCRWMQGFLFSEPLPVQAF------------
>tr|L0E008|L0E008_THIND Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Thioalkalivibrio nitratireducens (strain 
----------------------------------------------------------------------RAEFVSQ-SIPGYRVLDPAAEYIL------
--HVEPREGNRGVLGLNPASFSPAREAIAPFLLTQERAA-RGVVIADAF-LRERR------------VAYATLTFGLFTGLSGQARRIGTVEQRTAELAR
TTWSLRDQQR--------------------------------------------------------------TPDAV--EL--DC--GLRNPGASSIVHV
VWKGGRLQRVLGTAQDVTEARRAETDIQRLAHYDGLTGLLNRNLWAMRARSALDIAQRHGDCLAVLFLDLDQFKTVNDSLGHRVGDGLLAETGHRLQSCM
RKEDLLARLGGDEFVALLPRLARPHAGTVARKMLDVLARPMVVDGHELTLSASVGIAVHPADGADVDTLLQHADTAMYSAKDAGRNTFQFFVQEMNVRVL
RRLRVGSGLRRALDRNEFTMHFQPQFDAETLVLVGVEALLRWQHPEHGSMLPGEFIPVAEESGLIIPIGDWVMRTVFKQQARWREQGHRHLSVAVNISAL
QFARPDFADKVARIIAETGADPSRIELEITESALMDGSPSLSRRLQTLTGMGLKLALDDFGTGYSSLAYLKRLPLDRLKLDRSFVRDLPDDPDDAAIALA
AISVARDLGMQVIAEGVETPGQREFLIAHGCRWMQGFLFSEPLPVQAF------------
>tr|T0AYV9|T0AYV9_9RHOO Uncharacterized protein OS=Thauera terpenica 58Eu GN=M622_14300 PE=4 SV=1
----------------------------------------------------------------------RDEFLRASGQPDFHIVDPARAYIT------
--YIEPLEANLRALGVNPLSLAPAVEAIDPFRLVQETDS-SGVVVATAY-IQSQR------------AAWTTVATGLFVGLTGNTRRIAAVERRTRELQT
TTASLREKQQ--------------------------------------------------------------APGQA--SL--DC--HTDTT-PAHIVHF
QWHEGTLLRLRGTVQDVTEAREADAHIQFLAHFDTLTGLPNRTAWIKHAREALAAAERHGDRMAVLFLDLDNFKTINDSLGHPVGDRLLASVARRLSACL
RGSDRLARLGGDEFVALLPRLDHAEGAVAAQKMLEVLGEPVRIDEHELRPSVSIGIATYPEDGNTIDILLKHADTAMYGAKAAGRNNFQFFVAEMNQRAN
ERLQLESALRRALGGNQLSLHYQAQIDTASGQVVGCEALLRWHHPQRGMVAPDTFIPVAEDSGMIVPIGDWVLREACRQQAEWRNQGLGGLTLAINISAI
QFQRESFPETVQSILAETGADPTAIELEITESALMQPGPVLSARLQKLVDLGLTLALDDFGTGYSCLAYLKRLPLSRIKIDRSFVTDLPGNTEDAAVVSA
ALSLAHDLGMEVVAEGVETAAQRAFLTERKCTLMQGYLFSRPLDAASF------------
>tr|N6YDF6|N6YDF6_9RHOO Diguanylate cyclase OS=Thauera sp. 63 GN=C664_01530 PE=4 SV=1
----------------------------------------------------------------------RARFVRASGHPDFQILDPAADYIV------
--YVAPLEHNASAIGINPMSLSPAAQAILAFRLVQETGA-KGVVLATNY-IYAQR------------AAWGAVATGLLTGLTGHTRRITGVDRRTRELEA
TTATLRENQE--------------------------------------------------------------APGQV--TI--DA--RTDRE-PARVLQF
QWRDGALAHIRGTVQDVTEARQAEAHIQYLAHFDTLTGLPNRSAWIGQAQGALRTAERHGDRLAVLFLDLDNFKTVNDSLGHPVGDRLLAAVARRLSGCL
RGEDRLARLGGDEFVALLPRLEHPGAATVARKMLEVLDDTLRIEDHDLRPSVSIGIALYPDDGQSVDVLLKHADTAMYGAKAAGRNNFQFFVPAMNERAN
ERLKLESALRRAVAGKQLLLHYQPQIDTRSGRAIGCEALVRWQHPERGLVPPAQFIPIAEDVGMIVPIGEWVLREACRQQAEWAAAGLRDLTVAINISAL
QFQRADFPDVVARILDETGADPAAIELEITESALMNPGSEQLERLNRLIERGLTLALDDFGTGYSCLAYLKRLPLSRIKIDRSFVADLPGDTEDAAVVSA
ALSLARDLGMDVVAEGVETPGQRAFLAERNCTLMQGYLFSRPLDAGSF------------
>tr|N6YLI4|N6YLI4_9RHOO Diguanylate cyclase OS=Thauera sp. 27 GN=B447_00410 PE=4 SV=1
----------------------------------------------------------------------REAFMRE-DTPGYRILDPAAQYIA------
--FVEPRESNLSVIGMSPYALPAAAVAIEPFRLVQERDD-RGMVVATAY-LLSLR------------AALGTVVVALLTALSGNTRRIAAVERRTQELEA
THADLHDKQE--------------------------------------------------------------AAGLR--TI--DC--RTLSE-PPRVLHL
QWSEHGLGRLRGILQDVTRARESEAHIHYLARFDTLTGLPNRSAWLEHGAVALRSATRHHDRFAVLFLDLDNFKTINDSLGHAMGDRLLETVAHRLSACV
RAEDQLARLGGDEFVALLPRIAGPTAAAVARKMLDVLAATIELDGHELRPSVSIGIALFPEDGDTVEILLKHADTAMYGAKAAGRNNFQFFTADMNVRAT
ERLLLENALRRAIATDQLSLHYQPQIDTRSGRTMGCEALVRWNDPAQGPISPARFIPVAEDSGLIIQLGDWVLREACRQQVRWSQAGLGEVCIAVNISAL
QFRRAEFVDSVVAILQETGASPSAIELEITESALMQPGEQLLERLHQLVGHGLSLALDDFGTGYSSLAYLKRLPIARLKVDQSFVADLPGDPEDAAVVTA
TLSMARDLGLEVVAEGVETQQQRAFLCERQCTLMQGYLFSRPLAADDF------------
>tr|N6YV30|N6YV30_9RHOO Diguanylate cyclase/phosphodiesterase with Chase sensor OS=Thauera aminoaromatica S2 GN=C665_14978 PE=4 SV=1
----------------------------------------------------------------------RAAFIRSDYRVDYRILDPATEYVT------
--HVEPEEGNHAVLGMDPLSFPVAGEAIERMRLVQEHGE-HAVVLALRY-IEQLR------------AAWGTIAVGVLSAMTGNRRRIQAVEHRTAELQA
ASVRLHESRD--------------------------------------------------------------EPGRI--ML--DC--NTDSL-PMRTLQF
RHVGGRLRRIRGTAQDVTALREAEARIRYLARFDPLTGLLNRSAWQDHAQDVLRHAARHDDRCAVLFLDLDDFKTVNDSLGHAAGDRLLAQVACRLGGCV
RAEDLVARIGGDEFVILLSRLAHAEPARVAERVLDALARPLQIDSQPLRVGASIGIALYPADGGEIDTLLKHADTAMYEAKESGRNAYRFFLPEMTQRVT
RRLQTEAELRKAIESGDLRLHYQPQIDAASGRVYGCEALVRWQHPERGLLPPDRFVPFAEQSGLIVPLGEWVLREACLQQVRWRDAGLPPLDVAVNISAL
QFRRRDFVATVARVLGETGADPARIELEITESALMDATPELVASFDQLVALGLTLALDDFGTGYSSLSYLKRLPLRRLKIDRSFVDGLPDNPEDAAITSA
TLSLARDLGMEVVAEGVETEDQRGYLCKRGCRAMQGYLFSRPLGVEEF------------
>tr|N6ZQ45|N6ZQ45_9RHOO Diguanylate cyclase/phosphodiesterase with Chase sensor OS=Thauera phenylacetica B4P GN=C667_14072 PE=4 SV=1
----------------------------------------------------------------------RDTFMRVERRMDYRILDPAVEYVT------
--HVEPEEGNRAVLGMDPLSFPISGEAIRRMRLVQEHGE-HAVVLALQY-TEDLR------------AAWGTIAVGVLSGMTGSRRRIQAVERRTAELEA
AGARLQEHRD--------------------------------------------------------------EPGRI--ML--DC--NTDSL-PMRTLQF
RHIDGRLRRIRGTAQDVTALREAETRIRYLARFDPLTGLLNRSAWQDHAQDVLRHAVRHDDRCAVLFLDLDHFKTVNDSLGHAAGDRLLAQVACRLSSCV
REEDLVARLGGDEFVILVSRLAHTDPARVAERVLDALARPLQIDGQPLHVGASIGIALYPADGGDIDALLKHADTAMYEAKESGRNAYRFFLPEMTHRVT
HRLQVEAELRCAIETGELRLHYQPQIDAATGRLCGCEALVRWLHPVRGLLPPDQFIPFAEQSGLIVPLGEWALREACLQQVRWRDAGLPPLDVAVNISAL
QFRRRDFVATVARVLAETGADPARIELEITESALMDATPELVASFDQLVALGLTLALDDFGTGYSSLSYLKRLPLRRLKIDRSFVDGLPDNPEDVAITSA
TLSLARDLSMDVVAEGVETEEQRTYLRSRGCGAMQGYLFSRPLGVKAF------------
>tr|A0A073KJQ0|A0A073KJQ0_9GAMM PAS/PAC and Chase sensor-containing diguanylate cyclase/phosphodiesterase OS=Shewanella xiamenensis GN=SXM_3824 PE=4 SV=1
----------------------------------------------------------------------KQSFTTAELGRPFNIKYGGKP-DGWLVPVK
--YVQPMYSSRAVLGLDLNSESARAAAIAKIQLAED-PHLGGTLLESAQLMGESY-----------LSLLLLLLAFI-CAVSGERHRIEDVSKEIARNQA
FQATLVESEN---QSGEGITIIDANDVIVDVNSAFSQITGYSRDEIIGKNCRFIEAARTDKNIDAQVRAALEQTGFWQGEVWDRHKDGYDFPKWLMMSVV
RDETGAISHYIGSFTDISERKVNEERIHFLAHHDSLTLLPNRLSLQSRLEMVFQEAFVSQTQIAVMFIDMDHFKNINDTLGHHVGDMLLLEVARRLKSIV
SSDDIVARLGGDEFVVVLSDTDHDSVAKVAEALRSGLNQVYIIDNKPLHSSPSIGISLFPTDGDSVEALMKNADMAMYRAKAAGRNNYQFFTAAMNTLVT
ERQQIETGLRQAIARDELLLHYQPQIDINTGQMVSVEALIRWQHPELGLVAPDCFIPIAEEIDMIIPIGQWVLEQALAQLAQWRKKGAKDLRMAVNLSAH
QLRKETIVADIINVLAQYDLGKGALELEITESVAMQYPEQNAKLLAELRQYGIELAIDDFGTGYSSLSYLKLLPLDRLKLDRSFVKDIENDPNDAAISAA
TISMSHELGLTVVAEGVENEAQLVLLSSMGCDLVQGYYFSKPLSADDC------------
>tr|A0A098UC33|A0A098UC33_9BURK Uncharacterized protein OS=Massilia sp. JS1662 GN=IA69_07220 PE=4 SV=1
----------------------------------------------------------------------RPAFVRTHVDPNFAGVRPAGPYLL------
--YTWPP-SNARIRGVDFLTAPGRRDAVSPIKVVG-TG--NGISLPTAY-MEGER------------ASWIVITTGLLAALSGERAQIEAVA-------E
RTARLQAILD--------------------------------------------------------------RPEER--QLLNAC--GEPLPLAVAVSIV
DR------LYVCILRDLTEQQRAQARIHRLAHHDPLTGLENRHALGMRLEQQLAQARRTRQPLAVLFIDLDHFKKINDSLGHQAGDELLVGAAARMKDLL
RDVDALARLGGDEFIIVLCGPLSPDVSAVAVRLVASLQQPYRLAGTTAHSGASVGVALFPEDGQDADTLLRHADMAMYAAKREGRGNFQFFSPAMNAATH
EHLLLENRMWATLENGGFDVYLQAQVELDTGRVIGAEVLLRWYDPELGSVEPGRFIPIAEESGLILPLGDWVLGRAMALLAEWRDDGMDHLRLAVNLSAR
QFSGGALLARLDALLAEHAIDPARMELEITETAAMRDPEITRGLLQQLRARGFKLAIDDFGTGYSSLAYLKLFAIDRIKIDRGFVRDIETNPNDAAIVDA
TIGLAHALGLGVIAEGVETHAQWGFLRDRNSDEAQGYLFGRPMPAPEF------------
>tr|A0L2H7|A0L2H7_SHESA Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Shewanella sp. (strain ANA-3) GN=Shewana3_4029 PE=4 S
----------------------------------------------------------------------KDSFTSTELGEPYKIRYGGAP-DGWLVPVK
--FVQPMNTSRAALGLDINGEPSRAAAIAKIQLAED-PNPGGTLFESSSLMGDTF-----------LSLLMLLLAFI-CAVSGERHRIAEVSKEIARSQT
FQATLMESET---QSGEGITIMDANDIIVDVNSAFTQITGYSRDEIIGKNCRFLEAERTDRSIDAQVRAALEQTGFWQGEVWDRHKEGFDFPKWLMMSIV
RDETGAISHYIGSFTDISERKVNEERIHFLAHHDSLTLLPNRLSLQSRLEKVFQEAFISQTQIAVMFIDMDHFKNINDTLGHHVGDMLLLEVARRLKNIM
GNDDIVARLGGDEFVVVLSDTDHDRVAKVAEALRSGLNQTYLIDNKPLHSSPSIGISLFPTDGDSVEALMKNADMAMYRAKAAGRNNYQFFTAAMNTLVT
ERQQIETGLRQAIACNELLLYYQPQVDISSGQVVGVEALIRWQHPELGLVAPDRFIPIAEEIDMIIPIGQWVLENALAQLAEWRDKGAKGLRMAVNLSAH
QLRKDTIVADIINVLTKHKLGKGALELEITESVAMQYPEQNAKLLAELRQHGIELAIDDFGTGYSSLSYLKLLPLDRLKLDRSFVKDIESDPNDAAISAA
TISMAHELGLTVVAEGVENEAQLVLLSGMGCDLVQGYYFSKPLAADDC------------
>tr|G0AVH5|G0AVH5_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Shewanella baltica BA175 GN=Sbal175_4170 PE=4 SV=1
----------------------------------------------------------------------LPSFTRSAIGGPYKVTRGWQT-DGWLVPVM
--YIQPIIGNEAALGLDLNSEPTRAAAIAKIQLAQD-PNPGGTLLQSAVLMGDTF-----------LSLLMLLLAFI-CAVSGERQRIAEVSKEIARRQA
FQATLVQSEN---QSGEGITIMDANDIIVDVNSAFSQITGYSREEIIGKNCRFLEAERTDKGIDPQVRAALEQTGFWQGEVWDRHKHGYDFPKWLMMSVV
RDDAGAVSHYIGSFTDISERKVSEERIHFLAHHDSLTLLPNRLSLQSRLEVVFREALASDSQIAVMFIDMDHFKNINDTLGHHVGDQLLLEVARRLKNIV
GDTDTVARLGGDEFVVALSNTNHDEVASLAEALRSGLSQTYIINNQALHSSPSIGISLFPTDGDSVEALMKNADMAMYRAKSAGRNNYQFFTAAMNTLIT
ERQQIETGLRQVLANDELRLHYQPQIDIRTGQVVSVEALVRWQHPEFGMVAPDRFIPIAEEIDMIIPIGQWVLETAMAQLAAWRAAGATELRMAVNLSAH
QLRKDSIVADITNVLLKHQLGKGALELEITESVAMQYPEQNARLLAELRQHGIELAIDDFGTGYSSLSYLKLLPLDRLKLDRSFVKDIESDPNDAAISAA
TISMSHELGLTVVAEGVENEAQLVLLSSMGCDLVQGFYFSKPLAAEEC------------
>tr|A4YC79|A4YC79_SHEPC Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)
----------------------------------------------------------------------QESFASAAISGAYNVKRNWQV-DGWLVPVM
--YIQPLANHEAVLGMDLNSEPIRAAAIAKVQLAPD-FTPSGTLLQSTMLMGDTF-----------LSLLMLLLAFT-CAVSGEHHRIAEVSKEIARSQA
FQATLVESEN---QSGEGITIIDANDIIVDVNTAFSQITGYSREDIIGKNCRFLEAKRTDKSIDPQVRAALEQTGFWQGEVWDRHKDGYDFPKWLMMSVV
RDESGAVSHYIGSFTDISERKMSEERIHFLAHHDSLTLLPNRLSLQSSLEIVFGEALASQSQIAVMFIDMDHFKNINDTLGHHVGDQLLLEVARRLKNIV
DNNEIVARLGGDEFVVVLSDTNHDEVASLAEALRSGLSQTYIIDNNSLHSSPSIGISLFPTDGNTVEALMKNADMAMYRAKAAGRNNYQFFTAAMNTLIT
ERQHIETGLRQVLANEELQLHYQPQIDIRTGQVVSVEALVRWQHPEFGLISPDRFISIAEEIDMIIPIGQWVLETAMAQLAAWRAAGATRLRMAVNLSAH
QLRKDTIVADITNVLLKHQLGKGALELEITESVAMQYPEQNARLLAELRQHGIELAIDDFGTGYSSLSYLKLLPLDRLKLDRSFVKDIETDPNDAAISAA
TISMSHELGLTVVAEGVENEAQLVLLSSMGCDLVQGYYFSKPLPAEEC------------
>tr|L9PK70|L9PK70_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC and CHASE sensor OS=Janthinobacterium sp. HH01 GN=Jab_1c06240 PE=4 SV=1
----------------------------------------------------------------------RSAFARAHVAPGFEIRQTAVQYAT------
--FIEPE-ASRAYQGLDLLSDPQRRAALEPLLLIP-SQS-AGLLLPTAY-LQQQR------------QSWTVLTCGLLTGLSGERARIQAVKDSTARLRE
REARLQAILD--------------------------------------------------------------VTHEY--ELWRSD--GNEFPLAMSVSEV
EH------LFVAILHDLTEQQLAQERIHRLAHHDTLTGLDNRLSLNLRLDQLLAQTRRGGGAAAVLFIDLDHFKKINDTHGHQTGDLLLVAVAQRLQELL
REVDTIARLGGDEFIVVTSGSVTPDASNIAVRIVDSLGSPYHLQGKTVHSGASVGVAMFPSDGEDGSTLLRHADTAMYAAKSQGRGNFQFFSAAMNTATH
ERLLLENRLWQALEQNEFELYLQPQIELASGRIIGAEALLRWHHPELGMVGPDRFIPIAEESGLILPLGDWVLQRASHLLASWRAPGLSHLRLAVNLSAR
QCHGAGLLPHLDRLLDTHGIDPALLELEITESAAMQDPERSRALLVELRSRGIKVAIDDFGTGYSSLSYLKLFEIDRIKIDRGFVKDIESDPNDAVIVAA
TIALAHSLGLGVVAEGVETQAQRSFLRAKGCDEAQGYLFARPMPVAQF------------
>tr|G4T2F6|G4T2F6_META2 Putative Diguanylate cyclase OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) GN=MEALZ_1910
----------------------------------------------------------------------DKT-AWTIK---YSAKKPISEQ--------
--------------EIVFALEPQA----TKILAFG---NSRQFFIPDGF-LGNYY-----------PVWGILAGGML-TSLTGQTELILVVEKRTHDLNQ
SNRK----------TQEGIMITDKKGRILRVNNAHTEITGYSSEEVIGKIPSVLSSIHHNRDCFDEFWKQLASQGQYEGEIWNRRKNGEVYPEWQTVTAV
KNEAGEITHFVSIFSDITEKKENESRIHNLAFYDPLTNLPNRRLLINRLEKEIAIAKRHGHFGAVIFMDLDHFKFLNDSLGHHVGDELLIQVANRLQSVV
RDEDTAARLGGDEFIVLINCNAKNLALTVAEKINAKINEPFLLNAFQHQLSPSMGITLFPDNDDNPDRILQQADTAMYRSKASGRNSISFFHPSMQEAAD
LRIKMENELREAIDQGHFVLNYQAQFGAKN-EIIGAEALIRWQHPQKGLIPPVEFIKIAEESRLILQLGRWVIMEACLQIQSWQQNGL-VPRIAINVSSN
QFRQSNFVDQIEHSLKVSGITPDCLEIELTEHVVIDNIEDTIEKMKALKALGLSISIDDFGTGYSSLAYLKQLPLNQLKIDKSFVRDISTDPNDAIIVET
MIDMAKHLGLTMIAEGVETAEQLAFLKSKGCTGFQGYYFSHPVTADQF------------
>tr|A1SX34|A1SX34_PSYIN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Psychromonas ingrahamii (strain 37) GN=Ping_2308 PE=4 SV=1
---------------------------------------------------------------------------------NIKKATEQVPGALYQADGS
SRFPYASEGIRNVYELSPLQLKKDADLAF-KRIHLDDVEAIHQQIAKNLTV---WHQQYRVVLPKAGIRWLEGNATPEARANGST-LWHGYINDITERKA
LELTLSNEFVTLSSIGDAVITTNEQQVVEYINPIAEHLTGWALADAIGQPVTRFNIILVAKTAIARCLDERAIVGPVCDTVLLSKDGNEYWVEKSAAPIF
APG-DVIIGVVMVFRDVTGQKRLREEAYHRASHDHLTGLANRREFDRMLLEMFESSISPGVAHVLCCIDLDQFKLINDSCGHFAGDTLLKEISVVLTQTV
RAKDLVARIGGDEFAILFQSSDLAAKQ-IAQDVCDKIAIRFHHKDKFYHVGASIGVVPLDGRWDNAEAAQQAGEIACFAAKHEGRGRVHMYTDLDVMEQR
DQMQWASRLQQAIDENRFELFAQPIMALDEQAEQGFEVLLRLRETGGALVSPAVFMASAEQFGLATQIDHWVVNNVLKWMKTHADELEKVHIIAVNLSGN
SVGDRDFHQFLIEALDHAQVPVQKISFEITETAAIENLDIATEFIAMVHQRGAKISLDDFGSGMSSMAYLKKLPVDYLKIDGQFVKDMENDTVDCAMVRS
IKQIADLTGKITIAEFVENAKILMLLKDIGVDFAQGYHIGKPQPINEIFAWKNITNTR--
>tr|F1VXK2|F1VXK2_9BURK Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Oxalobacteraceae bacterium IMCC9480 GN=IM
---------------------------------------------------------------------------------RVKKATEQMPGAIYQADGT
SRFPYASEGIRELYEVSPMQLRRDAKLVF-QRIHPDDLVEVTEGVRLALSP---WIQQYRVNLPRQGLRWLEGRSIPEARADGSV-LWHGYLVDITERKA
LEIVRTIEHVTLRSIGDAVITTNRFGLVEYLNPVAESLTGWRCIEAIGQPVDQFRIVAGVGNPVARCLAEGAITGATADALLIARHGAEYAVEDSAAPIF
GAD-RLVSGAVMVFRDVTPQRKLHQEAEHRSRHDHLTGLPNRREFEHLLEQLFVSARSEDVEHALCFIDLDRFKAVNDSCGHAAGDLLLKKVSDLLRQCV
RATDKVARLGGDEFAVLLQHCDLTARQ-IAQDICDHMAMRFLFDGKQFDIGASIGVVVLDGSWSSTSQVQQAADQACFAAKAAGRGQVQVGIGSGGAAPE
APMPWSIVLQQALDNDRFVLFVQPVVGLDDG--SGVEVLLRLQDDNGALILPGAYLPAAERCGLAVSIDRWVLARTCRWLASASGQ--AVASVAINISGA
SVVDPDFHQFVAGTLDG--MPAGKLFFEISESVPIEHPVQSQVFFDAMHRAGAQLGLDDVGRGLTSMAYLKRLQVDYLKIDGQVVTSMASDAVNGAMVRS
INEIGHLLGMRTVAEGVESEAVLQMLRVMGVDYAQGYHTGKPQPIG--------------
>tr|D9SGK5|D9SGK5_GALCS Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Gallionella capsiferrifor
---------------------------------------------------------------------------------LLHKLSDHVPGLIFQVDGH
MSFPFASRAMLELYGVEADAVRDDATAVF-AFQHPDDTAGIAASIQRTLTP---WHHEYRILLPEQGVCWRRGDARPEKQVDGSI-LWHGFITDITENKK
IEARLELASRVFETTGEAIVVTDVSGAIIAVNPAFCRITGYSEAEVVGKNPRMYKSGLHKQAFYRDFWSELIKHGQWCGEIWNRRKNGELYAQWESVTTI
KDSKGNTSSYVAVFSDMSEIKKAQAEVEELSWRDPLTGLANRALFLRQVEQALVSSKRDDYFAAVLLIDLDRFKEINEARGLAIGDALLRSVADRLGQTL
HRDDLLARLDSDEFAVLLPRLHIREKAGVAEKLRAALRCAIEMDGEFIHVDASIGIAMLPDTPQEAIDVLRQADMAMTNAKAEGRSRTMFFESLMGETVR
ARFQLEAELRLAILEDQLRLYLQPQVNS-SGVQVGAEALVRWQHPTRGLTLPGLFIPLAESSDLIISIDRWMLSAVCRLLAE-LDAEGSSIRLSVNISPR
HFQQADFVSEIQHQLEASGADPSRLVLELTEGIVIGDIGDVIAKMTLLSTLGIHFSIDDFGTGYSSLAYIKRLPIHELKIDKSFIQDCTSDPNDAALVET
ILSIAKHLHFQVVAEGVETLGQSEFLNARGQIIHQGYLYGRPEPAAVWRARLSQ------
>tr|G4SU30|G4SU30_META2 Putative two-component sensor histidine kinase OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 
---------------------------------------------------------------------------------HLRTLINALPDIVCFKDGE
GRWLEANDFDLKLFGLEHVDYRGKKDSEL-AYQDFYKESFL----ASDEKA---WQAGVITRV-EEDIPRPDGSSRTFEIDDGRRKGLVVVGRDIDERKQ
AEARHRLSTRVFETAGEAIMVTDADANIIAVNPAFTRITGYTEAEVQGKNPRLLNSGRYSKSFWAAMWRALQNKGEWAGEIWNRRKNGEMFLEWETISAV
RDERGNVTQYIAVFADLSEIRRAQEAAEKLAWRDPLTGLGNRALFLKELEQTLIAASREGRFAGVLLLNLDRFKDINEARGLAIGDELLKTVATRLLDAL
SDDDLLARLDSDEFAVLLTRQAPQEAFGLAEKLRAELRRGFEVEGELMHLDAAVGIALCSEGNGEAIDILRQADMAMHRAKTEGGGRVVFFETTMGDAVK
ERFKLEGELRTAIAEGQLKLYLQPQVDS-DGIQVGAESLVRWQHPERGLIMPGVFIPLAEATDLIVALDRWMLGSVCRILAE-LDGEGRSIRLSVNISPR
HFERSDFVGEIKRQLMLSGADPTHLVLEVTEGLMIGNLEDVVAKMTILSTMGIHFSMDDFGTGYSSLAYLKRLPIHEIKIDKSFIQDAPTDPNDAALVET
ILAVAQHLSLQVVAEGVETQAQSDFLKARGRVIYQGYLYGKPEPAESWLQRLRD------
>tr|G3ISL3|G3ISL3_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_1197 PE=4 SV=1
---------------------------------------------------------------------------------RLQKIASQVPGLVFQPDGS
SRIPYANEAIRSLYRVSPEEVSEDAAKVL-A-LHPDDLENFKTSFKRDLTP---WRQEYRLKFDDAPVCWLFGNALPQRQADGSV-LWHGFITDITKHKQ
TEVELRIAATAFELQ-DAMLVTDANNVILKVNQAFTRITGYSAEEVIGKTPNLLSSGQHDKTFYSSMWESINRTDAWQGEIWNRRKNGEMFPEWLIITAV
KEPDEHVNNYVASFSDITSRKAAEEEIKQLAFYDPLTQLPNRRLLQERLKHSIDVERRDGKRLALLMLDLDRFKAVNDSLGHLAGDELLQQVAVRISARL
RDVDMVARLGGDEFVVLLEDIAHEDAAR-AAEIIFVLGKPFQLQSSDVQIGASIGISLYPEHGASYEMLMDHADAALYQAKDQGRGCYAYFSEDQTLAAR
ERIALETRLRRAIEQGELRVFYQPQMDIESGRIVGAEALVRWQDPIEELIPPLRFIPIAEETGLILEIGAWVLRETCRQGRLWLDAGLPPLTLAVNVSPQ
QFRRGDISALVATALNETGFPAEYLELEMTESGLLENQDNVMALLNKLRSQGIRLAIDDFGTGFSSLAYLKHFPLDVLKIDKSFIDDIPNLQDDMEIAAT
IIAMGHILGFKVLAEGVETPEQLAFLREKKCDSYQGYIKSPPVPAEAFALLLRE------
>tr|U7NJZ9|U7NJZ9_9ALTE Diguanylate cyclase OS=Marinobacter sp. C1S70 GN=Q667_04360 PE=4 SV=1
---------------------------------------------------------------------------------QREELASHVPGMLYQP-GS
SHFPYASAKMREIYGVAPQDVVEDAPAF---ALHPEDRDRVHETLQQSLAL---WHDEY--QFPDGRVIWVEGEASPEA-PDGS-ILWHGYIHDVTSRRR
SAEELRLAAKVFEHAGEGILVTDAQGHIVNVNRAFSVITGYAREEVMGQTPRLLESDRYDDEFYQTVWQALREHDYWHGELWCRRKNGSQFAALLTISAV
PDMRGNIEHYAAMFSDITALKENQQQLERVAHYDLLTGLPNRLLLGDRLKQAIRQTRRRGMHLAVVFIDLDGFKKVNDQHGHAVGDKLLSVLSRRMTQVL
REDDTLARLGGDEFVAILVDLPDSVSVP-LERLIEVASQPVPIGDALCEVSASIGVSYYPQGEDIADQLLRQADQAMYFAKQAGKNRYHVFDTEKDRTLR
TRHEGLDSIENALANGQFLLYFQPKVNMRTGEVLGAEALIRWQHPTRGLLSPASFIPIIENHPLGIDVGKWTIEAALTQIEVWRK-AGLHVPISVNIGAR
HLLQPDFIMHLRGMLSHPGVQPQDLELEILETSAVEDFVQVSQLMALCERMGLRFALDDFGSGYSSLTYLKRLPAYLLKIDQGFIRDMLEDPDDIAILDA
LLALARSFGRNCIAEGVESIQHGEMLLRLGCEWGQGYAIGHPMPAHEFEQWLHTWQVP--
>tr|U5NAT5|U5NAT5_9BURK Signal transduction protein OS=Candidatus Symbiobacter mobilis CR GN=Cenrod_2636 PE=4 SV=1
---------------------------------------------------------------------------------MSAATPNLLNPHPTVDLAQ
DAYLVHLRALIDQQGLRPDVVLLDLPDS---GIDTV---------------------ES--LLVEAPIIVLTGLDDTLATCEVH-ALHRAVR-YAMLRHL
RDADARLAATVFAHARESIVITDTQGMIVDVNATFTQVTGFSREEALGRTPRILKSGCHGPDFYAVLWGRLLETGHWVGEVWNRRKDGVVYVASLTISAV
YDGRGKVRHYVGLSADITLQKENEKQLKYIAHHDALTRMPNRVLLADRMQLAMAQSQRRKLELAVVYIDLDGFKAINDQRGHQAGDQLLITVADRMKLVL
REGDTLARLGGDEFVALLTDLSDSGCES-TARLLQVAAEPVLLDGVTLQVTASVGVTFFPQPEDVADQLLRQADQAMYQAKLSGKNRVHYFDITSDLVAR
GHYAGIDRIREAMTSNELVLYYQPKVDMRTGVVVGIDAQPFWKHPQRGLLPYGSFQGVIEDHPLAVSLGEWAIGGVLQQLQTWQE-QGVELPISVNVGAR
QLQQSYFVDRLKRLLAYPDVPAHRLELEVLESVALLDLQQLSDVMQGCRALGVSFALDDFGSGYSSLTYLKRLPIAMIKVDANFVRDMLFDAEDLAILGG
LMALARAFRRQVVAQGVSTVEQGTMLLLLGCEVVQGDFISSPLPADAVPGWIAQWRTP--
>tr|Q1NUH5|Q1NUH5_9DELT PAS:GGDEF:EAL:Response regulator receiver OS=delta proteobacterium MLMS-1 GN=MldDRAFT_5213 PE=4 SV=1
---------------------------------------------------------------------------------TVRKSDGELPAMPLVDRNV
DAFALHSTRLLTGEGVVPDVVILDLPDS---GIRTV---------------------ER--SLCDSPIVVLSGNDEPEDRGDGP-TLRRALR-YAIIRHR
RDSDMRLAAAVIKHTREGITISRSDGTIIEVNDAFCRITGYRREEVIGQNPRLLQSGRQDREFYVEMWRALTEEGFWSGEIWNKHKEGRIYPQLLTISAV
PDGTGKPGHYVAIFSDISEIKEQQQRLERIAHYDTLTGLPNRDLLADRLNHAMVQAIRRQTRLAVAYLDLDGFKAINDTHGHDVGDFLLRTLAGRMQQTL
RESDTLGRLGGDEFVAIFQDLPDETCLP-LQRLLNAAAMPVSYQETILQVSASLGVTFFPQSEKIADQLLRQADQAMYQAKQTGKNRYHLFDAVQEVAMR
GHHELLGRIKRALNDQEFLLYYQPKVNMRSGVVVGLEALIRWQHPELGLLAPTYFLPAIEDHPLAVAVGDWVLATALAQLAAWRR-AGISLPLSVNISAR
QLQQDDFVAKLEQQMAWPEVPADQLELEVVESSALADIDQVSKIITQCRAMGVGFALDDFGTGYSSLTYLKRLPARTLKIDRSFVADMLDDPDDLAILEG
VLGLARAFNRQTVAEGVESAAHADSLLKLGCEVAQGYWFAKPMPMAEVAAWVAAYETR--
>tr|U5N7D3|U5N7D3_9BURK Signal transduction protein OS=Candidatus Symbiobacter mobilis CR GN=Cenrod_1127 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------RQ--------------RDQLEADIVERKA
AEAKLRLAARVFASACEGIVITDQHGTILEVNAAFTNITGYLREEVLGQNPRLLQSGRHSAAFYQAMWRDLRARGTWSGEIWNRHKSGIAYAELLTITAL
LDERGNPTNFVAMFSDITASKNHQRELELVAHYDPLTGLPNRTLVAERLRQGMTRVQGGSQRLAVAFLDLDNFKSINDAYGHHFGDQLITTVAKRLKQTL
RDGDTLARTGGDEFVAVLTNLDTAPNTP-LARLLEIASQSIDFGDHSVTMTASLGVTFYPQNTDIAEQLLRQADQALYQAKLSGKNCFHVFDADRDMGLR
SRHEQVDRIRQALLGGEMLLHYQPKVNMRTGQIVGVEALIRWQHPQRGLLAPAHFLPLIDESPLAIDLGEWVIDTALAQITQWRS-MGLPTGISVNVCAR
QLQREDFVPRLRSALQHPLVQPGDLSLEVLETSALEDIAGVSEVITQCSALGVEFALDDFGTGYSSLTYLKRLPVTLLKMDRSFVRDMLVDPEDTAILKG
VIGLAQAFGRAVIAEGVESIAHGTGLLELGCELAQGYAVAKPMPAEEYPAWATQWRPD--
>tr|W6LT17|W6LT17_9GAMM Putative Diguanylate cyclase OS=Candidatus Contendobacter odensis Run_B_J11 GN=BN874_270019 PE=4 SV=1
---------------------------------------------------------------------------------ADIALENVLPTLTQIPM--
-----------------TGYTAADWPGFW-AHVHPEDRPVALA---NQYRL---QHQGQRFCHHDGHYLWVNDRLVAQYD-GAI-SLLMGVWWDITGRKE
TEARLRLAASVFAEAHEGILITDIDANVVDVNAGFSMMTGYSREEILGRNPRFLRSGRQPPEFYVAMWQTLLDTGGWRGEVWNRRKDGQAIIVLLNISAV
KANDGMVTHYVGVLSDLTALRQSEQRLEHIAYYDPLTRLPNRNLFTDRMYQALAQADRQNTLLAVCYLDLDGFKPVNDTLSHAAGDKLLIAVAERLNRGV
RGDDTVARMGGDEFAVLLGGLSSEECEN-LTRLLRSLSRLHVFGDRSFEITASIGVTLYPND-GGTDALLRHADQAMYLAKQAGGNRYLMFDAEHDRRAH
VHRAQLSRIDTALTTGEFRLYYQPKVDLREGRVIGAEALVRWQHPERGLLPPSQFLPAIEGHPLLAKLDCWVLAEALNQMDRWQTQEGLPLTLSVNISAT
TLQQPDFPDRLAVRLAHPQIAPAQLELEVLETAALNDLNHTAQVLEQCARLGVSFALDDFGTGYSSLAYLRRLPVRTVKIDQSFVRDMLTDAEDMAIVEG
VISLAQAFQREVVAEGVETVLHGAVLLKMGCACVQGYGIARPMPPDALPDWVQNFDPH--
>tr|W6LWP2|W6LWP2_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Candidatus Contendobacter odensis Run_B_J11 GN=BN874_630011 PE=
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------------MTNSQ-ETPQN-LPL-TL-------QLGNAT
AEEQQRLMASIFAHTQEGIVITDAEATIVEVNHAFCELTGYSREEVIGHNPRLLQSGHHSPEIYAALWQALLDQGHWQGELWNRRKDGRMIAELMAIWAV
KDLCGAITHYIGIFSDITASKQSEQRLQQMAYHDALTRLPNRVLLLDRLQKEIARTDRQDILLAVCYLDLDGFKPVNDLLGHVAGDQLLIMVADRLRHCI
RESDTVARLGGDEFVVLFADLTREECHN-LDRLLRVLAEPYTVSNQSVEVTASVGVTLCPQD-GGADTLLRHADQAMYLAKQTGRNRYVLFDAEHDRQIR
AHRDQLSRIDTALDTGELRLYYQPKVDMYRGTVIGAEALVRWQHPERGLLPPSEFLPVIEGHILMVKLDHWVFTEALRQMACWHM-QGLRFAISVNVSAT
TLQQAGFPDWLAALLAHPQVPPQALELEIVETIALDDLGRVLPVIQRCITLGVGFALDDFGTGYSSLTYFRRLPVRTLKIDQSFVRNMLVDTEDMTIVEV
VINLAQTFQRAVIAEGMETALHGAALLRLGCHCAQGYGIARPMPPEAFPEWARGFTQH--
>tr|A0A085FU30|A0A085FU30_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Massilia sp. LC238 GN=FG94_00893 PE=4 SV=1
-------------------------------------------------------------------------------------------ELRQVD---
--------------ALSGRPVDAALSCL---LVHADDRQRARITLD---LS---GRRDRRFLDADGAVRWVEVVARACVD-------TVGTLFDVSDRRA
ARHQRRLTAGVFSSAGEGIIITSADGLIVDVNAAFEDITGYARAEVLGRNPRLLSSGRQDKAFYRDMWRSIEQTGSWSGEVWNRRKCGEFYVERLTIAGI
RDEDGALSHHVGVFADITRQKQQAQHLEHIAHYDPLTGLANRSLLADRLQQAMGRARRHGAGVAVACLDLDDFRLVNEVHGHEAGDELLVALGRKMQDAV
RESDTICRLGGDEFVVVFDGVESLTCQP-MTRLLQAIAEPVALGEARVCVSASAGLAFYPQGEDIADQLIRQADQAMYDAKMAGKHRFCLFDSQGYHVMV
ARAEEIEALEVALARGEFALHYQPIVHLRTGELNSVEALVRWNHPTRGCLPPGEFLPALEGHPLMLALENWILAEALRQHQRWLD-AGLDVAVSVNMSSA
QLHRKDFADDLRALLAHPRVDPRRIKLEVLESSALEDLDHVSDLIAYCARIGVGFALDDFGTGYSSLRYLKQLPARRIKIDQGFVRDMLHDPDDLAILEG
IIGMAAAFKREVVAEGVESDAHAAMLLQLGCLLAQGYGIARPMPPDALPAWLGGWRLP--
>tr|A0A085FYI8|A0A085FYI8_9BURK Diguanylate cyclase (GGDEF) domain protein OS=Massilia sp. LC238 GN=FG94_00176 PE=4 SV=1
-------------------------------------------------------------------------------------------NLKEVD---
--------------ELSGQDVGSSLYSL---FVHPDDRERKRELLR---VT---GERECRYLRNGSELRWVEVFARAIVG-------IAGTLNDISERKA
ADERLRLAASVFANAGEGIMITSPKGEIVDVNTAFEAITGYPREEVIGRNPRVLSSGRQDGAFYARMWESLQREACWQGEVWNRRKNGEFYVERLTITTI
LRDDGSLSNYIGIFSDITSQKRQAEHLEHIAHYDPLTGLPNRRLLADRLQQSMARARRSGSSVAVAYLDLDGFKIVNDRYGHEYGDELLVVLGQRIRAVV
RECDTACRLGGDEFVVVFDSIDCEDCRP-MERLLEAVARPVHVGQVALVVTGSAGISLYPQEDDIADQLMRQADQAMYQAKLAGKNRFCVFDSLHYRTAV
DRNEQIAGIRRALDKDEFVLHYQPIVNLRSGELNSVEALIRWEHPVRGCLGPAEFLPAIEGHAVMLDLENWVLEEAMCQHERWLD-AGLDIAISVNMSGI
QLHQDDFVRQLGRMLEHPRVKPRSLKLEVLESSALVDMQRVSRLISECSELGVSFALDDFGTGYSSLSYLKQLPAKRIKIDHGFVRDMLEDPDDLAILEG
VIGMAAAFKREVIAEGVESIRHAQMLVQLGCVLGQGFGIARPMPAQALPGWLAQWRLP--
>tr|H2CCH1|H2CCH1_9LEPT Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptonema illini DSM 2152
---------------------------------------------------------------------------------TREHLKQHAPYITIDREGR
DVL-------------KALDSSNSYDVLL-FFMLPDENALILTQE----LQ---RRPGF-----DLPIVFVTGHGNEEIVTLENVTGLHRLQRERSALAA
SEKRFRLLAEN---ARDIVIELLPSRAFTYVSPSSTRLTGYTPEEHYADPDLGYKIIDRVKIVLDEVFFSKPV-----VMRWIRKDGSTLWTEQENVPVY
D--EGNLIALEGIARDITERKESEERLDFLAHYDPLTGLPNRWSLIEQIEKRMKSVRERGRQLTLLLLDLDRFKMINESLGHRSGDLLLQSAAERLQQSI
AADEVLARPGGDEFGILIESDNDMTAEH-AFSIIDLMQTPFAFDQGLLYIGVSIGICSYPDAAANADELMRNAEAALYRAKDQGRNTYRLYTEDMTRKAL
DRLEIETLLREALANGELYLEYQPLVSVHSNAIFGAEALMRWKNPLRGVIRPDEFIPVAEESGMITRIGDFALLEACRSMKRLLDEGLPLRTIAVNISPR
QFLLQDVVASVKKSLAETGLRPEYLELEITESALMHDPDQSLQTLLALRDLGIRLAIDDFGTGYSSLAHLKRFPLHKLKIDRSFIRDIPHDLDSEKIATT
IVAMARGLELKVLAEGVETEDQRKFLEEHNCDFFQGYLCSPAVSAETLAELVKK------
>tr|Q1QUF0|Q1QUF0_CHRSD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / N
-----------------------------------------------------------------------------------DRLNAQVPGVLFHP-GR
GDFPHVSERLADYCGLER--MALTHECF--FRIEDDDRTRLRVSLTTSL--------RLRYHHPTRGLRWLECSAVPTR-SNGG-TLWHGYTTDVTARKL
ATERMALAETVFDSTHDGILVTDADKRIIDVNPAFTKLTGYSADEALGRKPHLLSSGKHDANFYHNLFATVHQQGYWTGDIWNVRKDGRQLIENATISAI
HDADGTITHYIAVFRDITQKHLKQARLERRAIYDPLTGLFNREHFGDALENLLSGLSYTGIGIAVLFIDLDDFKPVNDTYGHAAGDDALVTIAQRLKQQT
RSTDLVARLGGDEFVIALAGMRSEKAEK-AFKILDDLISPIALGEHAITLSASVGIAYTDD-SRFPDALIAAADSAMYEAKSRGKNQVAITEHQQ----A
NGDDLYTRLQTALDDGELALFYQPILSLNDERIVSFEALVRWYHPEQGLLAPHHFIDIVNHSSLERVYSAWLVNQAAHTVQRFQA-RDMAVTVSINVTRD
QVESGQLADDMAQAREHALASP-FLNVEVVETAQFHDIDLAYNQLQHARRLGAQIALDDFGSGVSSLTYASQLPIDIVKIDQAVIRHLAERPQQRRYVSG
IIDMAHAMQRVVLAEGVESVEQLDVLRQLGCDMVQGFLIGHPLPSQELEAHYLAEDAE--
>tr|H2CDM0|H2CDM0_9LEPT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptonema illini DSM 21528 GN=Lepil_2889 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------MIPSSEPCL---ALP---RPACL--LDKSVIT---CVNGAAFTQAVEAVKWDDGSTLLEAITPTA-QGMLCVFHDVESMRR
LSESASLVLPAVDQIQEGILITDAGGRILYVNAAFELQSGWKAEQIVGQSPSILKSGTHSDSFYGEMWNRLLSGHAYRGEMQNRRKDGTIYNVEKVITPI
FDENGRISHFVSTDRDVTEEKQAEEALVHQAMHDTLTDLPNRSLFSDRLRQALLRANRLNEKVAVLFVDIDRFKFVNDTFGHAHGDLILVAAARRIQSAL
RPDDTVSRQGGDEFMVLLPGLGKDHAAS-AEKVLASFEAPFAVNDTELTIGASIGIALYPDD-ASPDDLLRLADMALYRAKEEGRGRYVFYNAAQLKQSR
DRFEKEGQIRQAVREWQFVPYFQPRVHAHSGRMIAVEALIRWMHPVHGVLFPDAFIPIAEETGLIYGLGEGVFRDAVRSYSQWKHVFPEGFVFSVNLSAK
QFYQVGLLEKLRDTVHQAGLQARSFELEITESTVMNLDQKTLTVLHDLRREGFRIALDDFGTGYSSLTYLERLPVDTIKIDRSFVTGLADSPRKRHLVQA
MIMIAKALDLSVVAEGVERREELDLLLELGCEEVQGYLFGMPQPAEALFGALLE------
>tr|A6F7T4|A6F7T4_9GAMM PAS:GGDEF OS=Moritella sp. PE36 GN=PE36_20500 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------AQLASCWSEPRQPPTDDDFKLLEFAVQLSVIAIERYL
SDEKLRLSSRVFSDTNEGLMITDVTGKIIDVNPAFTRATGYSRSEVLGQKPSILASDKQSPAFFIEMWQSLMEQGYWHGEVWNKKKNGELFAARLSISSL
TNDDGENLHYVGLFSDITQIKQQQQKLEMMAHYDMLTKLPNRSLLADRFKSGIAHSQQTDTMLGVCFLDLDNFKPVNDSYGHDVGDQLLIAVAQRLKSNI
RDEDTASRQGGDEFVLLLGDIKSAHCDETLQRINYFLAQPYIIAGHTFNISVSIGVTLYPDDDADLDTLLRHADYSMYQAKLTGKNRFHLFNPERDQQKI
QKHQQLDEIKQALSNNEFALYYQPKINMKTGKVFGAEALIRWFHPEKGLIPPLDFLPIIEGSELENQIGDWVINQALKQIVEWQKLGIFM-EVSVNIASY
HLLSAKFLTLLESALASHNLDAQYLQLEILESSALGDLNTIRNILNTCDVLGVNIALDDFGTGYSSLTHLKNLPANTIKIDQNFVKNMLDDPDDYAIIKG
VLALADSFNREVIAEGVETTEHGLMLLSMGCYAAQGYGIARPMPASDIPNWLHN------
>tr|S6HYY3|S6HYY3_9GAMM PAS:GGDEF protein OS=Osedax symbiont Rs2 GN=OFPI_15330 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------AQLAACWSEPRKPPTEDDFKLLEFAVQLSVIAIERYL
ADEKQRLSSRVFSHTNEGIYITDVTRVFIDVNPAFESLTGYNRSEVLGQQTSILRSDKNTAVFFEAMWLQLIEQGHWQGEIWGTKKDGQHFAARLSMSTL
TNDDGVTLQYVCIFSDVTQSKQQQQRLELMAHYDVLTQLPNRTLLAERFASAIAHSKKTDTLLAVCFLDMDNFKPVNDSYGHEIGDQLLIAVAQRIKTII
PDQDTASRQGGDEFVLLLGDIQSQHCDEQLHQIHYTLAQPYQICGHTFNISVSIGVTIYPDDNADLDTLLRHADYSMYQAKLAGKDRSQFFNPEQDQKII
QRHHQLEEIQQAFTNNEFVLYYQPKVDMKSGEVFGAEALIRRRHPKKGLIPPIEFLPVIEGTELEIIIGDWVINQALKQIIEWQKQGIFF-EVSVNISSF
HLRTPSFLSALEKSLESHDLNAKYLQLEILESSALGDLNAIRSILNTCDELGVNVALDDFGTGYSSLTHLRNLPAGTIKIDQSFVINMLNDPNDYAIVDG
VLALARSFDRKVIAEGVETTEHGLMLLDMGCNAAQGYGIARPMPAQDVPNWLNC------
>tr|G8QJJ0|G8QJJ0_AZOSU PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Azospira oryzae (strain ATCC BAA-33 / DSM 13638 / PS)
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------DG-------T-TPLPGPDGSLRGVLGISTDITEIKQ
TTEQLRLAGVVMENTADGVMITDARGVILSVNKAFTDITGYTAAEALGQLPSLLRSDRQEPEFYRLMWETLASTGIWRGEIWNRRKNGALFPEWLTINAV
LDQEGKPVNYVGVFSDISAIKHSQDELERLAHFDPLTGLPNRTLFHDRLQHALERAQRYGQELAVLLLDLDGFKTVNDSLGHPTGDLLLQQAAHRFKECV
RVEDTVSRLGGDEFAIILNNLAQTDAISVVKKLLQALQEPFDLDGTAALVTTSIGIAIAPLDGDTPEALVRNADTAMYGAKEGGRNSYRFYQADMTRRAQ
ERLTQERSLRRALEEGEFEVWYQPKLELADGSLCGAEALLRWRDPARGLVSPAEFIPLAERTGLIVPIGELVLDQVCRQARQWADRGLLAGRIAVNVAAL
QIERSDYAATLRQALEKHGLPATALEVEVTESLIMESPNHARQVLCDIQTLGVTTAVDDFGTGYSSLAYLKVLPINHLKIDRAFVADLPHNANDVAIARA
IIALGHSLGFHITAEGIETQEQLEFLRGAGCDQGQGYLFGRPMPAADFTAWMQQ------
>tr|A0A059KSI7|A0A059KSI7_9PSED Uncharacterized protein OS=Pseudomonas mandelii PD30 GN=V466_30280 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------KN-------T-TVLRGADGQPTGILGISTDITGIKQ
NTEQLRLAGIVLDHTADGVIITNARGHILSVNAAFTKITGFNAEESIGLKPSILMTEKQDNAFYRNILKSLKVTGFWRGELWNRRKDGEMYPEWLTINTV
HNDAGKLTHYVAVFSDISAINQSQSDLERMSHYDPVTALPNRSLFHERLQHSLDLSLSYNQALAVVVLDLDGFKTVNDSLGHSMGDLLLQQAATRFLSCV
RSEDTVSRLGGDEFALILNNLTDTDAIIIAKKLLLSLQEPFDLKGVSTLLTASIGISVAPHDAETPEQLLRQADTAMYGAKESGRNDYRFYQPEMTLRAQ
ERMNSERFLRRAVLNHEFEVWYQPKINLLNNEVAGAEALVRWRDPIHGLVSPADFIPLAESTGLIIQIGEHVIDRVCSDIRRWTDLGILHGVIAVNVAAL
QIDRSDYVETLRSALEEYDLPATVLEVEVTESLMMASPEHSREVLSTLQSLGITTAIDDFGTGYSSLAYLKLLPINSLKIDRSFISDLPADKSDVAITKT
IVALGHALGFKIIAEGVETIEQNTFLKEIGCDQGQGYLYGRPMPAADFESWLNN------
>tr|J2IB68|J2IB68_9ALTE PAS/PAC and GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Alishewanella aestuarii B11 GN=AEST_28730 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------KDGHWVWILSRGRIVTEQGK--RLTVGTHIDISDRKE
SELKLQLLARLFEQSSEGLLITNSQQQVVMVNQAFCNISGYRPEEVVGKDPKLLSSGKHDKAFYQKMWQAIQQQGVWKGEIWNRRKDGTLYPEWLSISKI
DGPEPGEIYYVGLFSDITQYKEDEAQIRFLAQYDALTSLPNRALLMDRTEQALAIAKAQHQALALLFIDVDRFKQINDSLGHQVGDQLLILIAQRLATLC
RPEDTLCRLSSDEFVLLRPHTDADQAAQLAEQILPLMLTPYQVSGQELVLSASIGIALYPEDGQHFHELYRHADIAMYRAKEKGRNTYCFFTSEMQRYLA
RHLLLENALRRAIDNNELSLVYQPQYSLQQQKLIGFEALLRWQHPELGFVSPGEFIPLAERSGLVIPLGEWVLKTALAERAAWQQLT-SSETVAVNLSPV
QFRQPGLLTLIDAQLQAHQLSAAALELEITESAMVEDPAQAASLLDAFRHRGLRIAVDDFGTGYSSLSYLKRFALNKLKIDQSFIRDLLADADDRAIVQA
IISMANSLELETIAEGVETAEQQALLKQLGCQAIQGYHYGKPMQATAAREMISR------
>tr|F2JUF2|F2JUF2_MARM1 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------LDEDEKWFELSAVAPDDLKGRAAFYLFLVRDVTERIK
NEAELRISAIAFE-TQDAILITDQHNRIIRVNNAFEAITGYSESEVYGKNPAIISSGRHDRNFYRKLYQSLNNIGHWEGEIWNRKKDGTVFPEWLYITAI
KDEEERLLHYVATFRDITQDKNNQQRIEQLNYYDALTRLPNKTLFLEELEHRLDVMS-RYRRSAILYLDLDNFKDLNDYYGHKQGDLLLKQVASRLVDIV
RPQDTVARLSADNFVILLEDADVYRAKHVATKILDELKHPFVPGAHELVITASIGMTEFGADTHTSEDIVKQAEMAMYEAKQAGRAQSCFYQPKMHERVV
QRVYFETSLREALSKEQFSLHYQPQFDVN-KKLVGVEALIRWNHPENGLVPPGEFIPFAEESKLIIKIGEWVLMKACQVKADWLKHDAFRDNMSINVSAL
QFSQDNFVEQVRHALDQSGVNPNTIELELTESMLVNDQDDVIRKMQSLKALGVLISLDDFGTGYSSLSYLTRLPIDQLKIDQSFVSSFSEGSRESTIAAS
IINIGHNLNMEVIAEGVEQQSQFEWLKSQGCDLFQGYGLARPMPEEDLLSLLSQ------
>tr|A3YAL9|A3YAL9_9GAMM PAS:GGDEF protein OS=Marinomonas sp. MED121 GN=MED121_09523 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------IEGKEHWFELSVSISSDYNR--PCFVALARDISRRKK
AESELRIAATAFE-TQDGILITDTQHKIVRVNTAFQKITGYQEAEILDQNISLLRSGRHDEIFFQKIFACIDDCGYWEGEIWNRKKCGEIVPELTTISTV
YNDLKIPINYVYIIKDISLTKQNEQLINQLSYYDSLTCLPNRKMISEKVEQLIKQAQHPLIRHALLFIDLDHFKNINDSKGYSVGDKLLQEVAHRLIDTV
RSTDIVARFGGDEFILLLEGVDVYRAKKVSCLINDALAQVFEINGEHFYISSSVGITEIDESV-EVFDAFKHAELAMYEAKSSGRNRYCFYSPQMQEKIL
ERVNLETAMRKALIKDEFLLYYQPQFDDL-GVLRGVEALIRWHHPDKGIISPMQFIPLAEDSKLIIPIGEWVVREACNTLARWRDDPLLSQKVSVNVSVI
QFAQDDFVDLVRLILVETGASAKLLQFELTESMLIDDKANILAKMQGLKALGVLLSLDDFGTGYSSLSYLQQLPFDQLKIDQSFVRNLNGQGDQHPLALT
ITTMGHSLGLEVIAEGIEEKESLLKLQSFGCNLFQGYFMGHPMPLSKLEEVGLQ------
>tr|F9UDV8|F9UDV8_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_3060 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------LDGSQLWTLLSTNPLKDAAGRYIGTLGMLTDISARKQ
AEAELRIAAIAFE-AQEGMLVTDAEERILRVNEAFTRITGYTAEEAVGQTPRLLHSGRHDTHFFAQMWAHIERNGYWEGEIWNRRKNGEVFPEWLAITAV
RDDLGYVSHYVGTLNDISQRKEDEAAIRRLAFYDPLTGLANRRLLLDRLNQTLAAAARTGQDGALIFIDLDNFKLLNDTRGHQVGDLLLEEVAQRLTETV
RKSDSVARLGGDEFVVLLQDL--AMAEGVSEKIIAVLGMPYRLAGEEHTSTPSLGIAMFNREPHTAEEILKHADLAMYQAKAAGRNRLRFYDPKMQASVN
QRAALERELRHAIGEGQLVLHYQSQVDGQ-GRVSGAEALLRWRHPERGLIPPAQFIGLAESLGLALPLGRWVLASACAQLAEWARRPETAGTLAVNTSGA
HFRRPELVEDIRRALAESGANPKRLRLELAEATLLDDPDDSLGKMIALKETGVGFTLDNFGSGYCSLSYLKRLPLDQLKIAPAFVREVLEDCEDDATADS
FVALAESLGLALMAEGVETEAQRDYLAHHGCQIFQGFLFGLPGPPDALLPAGAQ------
>tr|Z5XT99|Z5XT99_9GAMM Uncharacterized protein OS=Pseudoalteromonas lipolytica SCSIO 04301 GN=AT00_14380 PE=4 SV=1
------------------------------------------------------------------------YADLENSTEQLSATLTALPDSVFELERD
GTFKAIYSDNSPNR-VFSNNVLGHN---ICQLFAPQHALQFIHSLQQNHLFGLFTIDALPL-LINGRTHHFEFSVTLFTY-ENEHETYLVVARDVTEKIG
QMAALLQQSQAVEQNPHPIMFTNTDAKIEYMNRAYLDMCQYGYDELIGQNPNMISAGQTDLGVYQGMWQQLNNKQAWVGSLVNKTKHGDAIVEQTTIYPI
FDKQGAISNYISFQHDMTKQVESESLIHQLSYFDQQTGLANQVKLQMEFEQVIKAH--VGIKSAFILIGLDNFKILNKALGIGNCNLILQNLSARMSNFM
GEQVMVARLQGDRFAFITPYT-SEEIDKCAHNLLKVIREPLSINDELIVVTASIGVALCPLDASDFESLLQMAESAMFEVKKLGRNNVLFYAEEMNKAGV
RHAQIINAINYALKNNEFSLVFHPQIELATNKMVAAEVLLRWHSASLGCVSPAEFIPIAERCGRISDIDDWVFENTVKTIRQWRDNGMPALTFAINLSAT
KFVKKNLLRSLTTVLQKYSIEPSCIELELTETIAIGNPQFALNTITKLREAGFKMSIDDFGTGYSSMGYLKEFALDKLKIDKSFIDNLEHPTADIAIVKA
MIDLAKALDMESIAEGVESEKQLQTLKELGCIQIQGYYHSKPMPIDAFYTYATHER----
>tr|A0A014P5K7|A0A014P5K7_9BURK Diguanylate cyclase OS=Comamonas aquatica DA1877 GN=AX13_06545 PE=4 SV=1
------------------------------------------------------------------------YLGLQQAEARQRATLETLPDLLFEMDRS
GVYLEVHANDPDRLAASNQQLLGRS---VTEVLPPEAAATCLAALEQAESQGVARGQRICL-SQADGLRYFELAVAKKAAPPGQPSTYLVLSRDVTDAVH
NEQHLMAESEALDQSPSPVMMTDTQASILYVNRAFTEVSGYSAEEVLGRNPRLLQSGLTPRSTYAEMWHKLPQGQSWQGELINRRKNGQTYTESASLYPI
RDAFGQVTHYVAHKEDISLRREAEERIRALSNFDTLTGLSNKKSFEEQLAQAIERSTAQHERLSLLWFNLDQFKLINESLGHAAGDELLVEQANRLRHSL
GTQVPLARYSSDVYVAIVPRA-DAAVALMVQAALTLLQTAVRLQGHTLMTSASAGVAVFPDDAQTAGTLASAAEVAMYRAKQDGGNTLRFFAPEMQAHTR
RSLELASGLKHATAHGELFLVFQPQCALDSGALTGAEALLRWRHPQWGLVSPAEFIPIAEQSGTIVAIDLWVLEHAALQLRAWDAQGLPELVVAVNVSAA
QFGRPQFVEEVLATLQRVGVAPQRIEMELTEAVALKQPEQAEITIRKLHAAGFRVALDDFGTGYSSMSYLKRYAIDKLKIDQSFVRDLAEQGSDQAIVTA
IIRMAQSLGLRTIAEGVETAEQAQLLQAYGCDEMQGYWYSRPLEPQAFAAFAQRHR----
>tr|A1W268|A1W268_ACISJ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax sp. (strain JS42) GN=Ajs_0088 PE=4 SV=1
------------------------------------------------------------------------YLDLRAAEARQRATLNTLPDLLFEVDRK
GVYLAVHANETSKLLTPLPQLLGKT---LDEALPPAAAAQCFEALAEAERTGMSRGQRITL-PLPLGERHFELSVSRKSAVAGQPDTFLMLSRDITPTVE
NEERIRSESEALDQSPSPVVITDIDASIVYVNKAFSEVSGYGAQEVLGRNPRVLQSGLTPRTTYADMWTKLPRGLPWQGELINRRKNGQVYTENASLYPV
RDVFGEVTHYVAHMEDITQRREAEERIRALSNYDTLTGLLNKKAFDEQLTQAIDRADASHERVSVLWFDLDNFKLVNETLGHAAGDELLLEMGNRLRACL
APHIPVARYSGDAFTAIVPLA-DAAVALLAQDALAQLQTTLQIHGHAVSVSASAGIAVYPDDARTASTLASAAEVAMYRVKQDGRNGLRFFAPEMQAHTQ
RSLELAAGLKDAAHRGELFLVFQPQRTLGSGALAGAEALLRWRHPRWGLVSPAEFIPIAEQSGSIVAIDFWVVEQVAQQLRAWDAAGLPPLVVAVNVSAA
QFARPHFVEELVRILQRMDISPQRIEVELTEAVALKNPEQAETTIRRLHEVGFRVALDDFGTGYSSMSYLKRYAIDKLKIDQSFVRELAHQASDQAIVTA
IIKMAHSLRMATIAEGVETAEQAALLQACGCDEMQGYWYSRPLEPAAFEAFVRNAQ----
>tr|E8TS74|E8TS74_ALIDB Diguanylate cyclase OS=Alicycliphilus denitrificans (strain DSM 18852 / JCM 14587 / BC) GN=Alide_0126 PE=4 SV=1
------------------------------------------------------------------------YQELQASEAQHRAMLDTLPDLLFELNRQ
GVYLSVHANDASKLAAPAGQLLGRR---LGEILPAQAAAACLDALAEAERSGVARGQRFRL-ALPSGVHHFELAIARKANPAGREDTYLTLVRDITATVH
DEQRIAFESEALEQSPHQVVITDVRANVLYVNRAFSEVSGYSAQEILGKNPRMLQSGLTPRSVYEEMWRRLPQGQPWQGELVNRRKNGHIYTEIVSLYPI
RDLSGQVTHYVAHKEDITVQREAEERIQALSNFDTLTGLLNKKSFDERLALAIERAGASHGRLSMLWFDLDNFKLINESLGHTAGDELLVEAANRLRSCL
GTQNALARYSGDAFVAIVPQA-DASVALMAQEALRLLQTATSVQGHPVSVSASAGVAVYPDDARTAGTLASAAELAMYRVKEDGRNGLRFFAPEMQAHTQ
RSLELAAGLKDAARKGELFLVYQPQRALGSGALVGAEALLRWRHPQWGLVSPAEFIPIAEQSGAITAIDFWVVEQAAQQLRAWDAAGLPPLVVAVNVSAA
QFARPQLAEELLHILQRVDVSPQRIEVELTEAVALKHPELAETTIRRLHDMGFKVALDDFGTGYSSMSYLKRYTIDKLKIDQSFVRELAEKTSDMAIVTA
IVRMAHSLHLSTLAEGVETAEQAALLHDCGCDEIQGYWYSRPLEPRAFEAFAKGLP----
>tr|C7RAA4|C7RAA4_KANKD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Kangiella koreensis (strain DSM 16069 / KCTC 12182 / SW-125) GN
------------------------------------------------------------------------FMKMSQLQSKLSATLNALPDLLIEVDAK
GNYLDIHSANPELLLRREEKLIGSN---IKEIMDKENAKRCMQAIETAGQIGRSQGTRIEL-QVPSGVRTFELSISRKKGHLDQPSTFLILSRDITSTIN
IEQHIAHESTGIDQNPYPVLITDTDGNIQYVNKAFIETTGFSETEAIGKNPIEFSAEQDPDKTFKMIWRQLARGDAWRGELVSRRKDGSHYTEFAMIYPV
RNNKGKIINYVAHKEDITLKKIAEEKIHQLSNYDQLTGLLKREMLEERLQQLLDDSFKQKQAMTVMWLDLDNFKTINDSLGHQVGDLILIEVANRLRFEL
GKQSIISRIAGDTFAAVLPLT-NHSAALIAKNVLEVVQRQIKFNSHILSISPSIGLAISPNDGQSADKLIMCAETAMYRAKHDGRNTFRFFAQEMQEHSL
RSLQLSIALKEALTNDQFHLVYQPQMSLSNNSMVGAEALLRWEHPEWGTVSPAEFIPLAEQSGLIVQIGEWVIQQVAQQQKSWLERGLPEVIIAVNLSAL
QFHQPDLVETITSLVRKAGVVPENIEVELTEAVALKDPEVAGTTIDALSRAGFKVSIDDFGTGYSSMSYLKKFAVHKLKIDQSFIKDIVTDIDDQAIVTA
IIQMAHSLHKTTIAEGVETQEQLDFLRKKGCEEMQGYWYSRPLVTEQFEQFLKSHE----
>tr|H2FWF2|H2FWF2_OCESG PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Oceanimonas sp. (strain GK1) GN=GU3_10890 PE=4 SV=1
------------------------------------------------------------------------YQQLHDARSRLQATMDALPDSLFEVTAQ
GEILSVYAGGDSGGVPAMQAGPRAR---VRDWLSAPAARVFFDALRNAEREGVVHDIRLRA-GEGANGRDLGLSVSKK--QHDGESRFLVLSRDISRQVA
NETRILHESTALEQNPYPVIITDDRVRIQFVNRAFTRISGYAADEVMGHNPKMLKSGKTEHRVYQEMWACLNQGQPWKGELINRRRNGSLYIESASIYPI
SDGTGRVVNYVAHKEDITQHRENEERLRQLSQFDQLTGVLNKHAFEQQLVQQMARTRLRGERLSLLWLDLDNFKSVNDTLGYVAGDELLVDISNRLRALL
APGSLIGRPEGDSFVLAVEGR-EESVALLAERVLQRVQQPVTLHDNPLSLSASLGIATFPHDGDTAVALFKAAELAMYRVKQDGRNGLRFYAPEMQKHSE
RALALATALKNALAGNELTLAYQPQLDLQRNRMTGAEALLRWRHPDWGLVSPAEFIPLAEQNGLMVSIGWWVIERVLEQLAALRRAGWTELTIAVNVSAV
QLVQPNFVRDLQARVEASGVPASALDLELTESVAMINPEDTGEKIGRLSAAGFRISIDDFGTGYSSMSYLKRFSVDKIKIDKSFIDEVTHNHEDKTIVNA
IIHMARNLGMSTIAEGVETEEQLNTLQRKGCDAIQGYWYSRPLPAEDLAGFVQEHG----
>tr|W8X105|W8X105_CASDE Uncharacterized protein OS=Castellaniella defragrans 65Phen GN=BN940_15791 PE=4 SV=1
------------------------------------------------------------------------YALLEESRRRLQATLEALPDLVVEMDAR
GRYLAVHAAQALEMSRRGSSLKGRL---VEDILPPQAAGTVLAALAEAGRQGVSRGRTVSL-RLGRDLRWFELSVARKPARPGGIDRYVVIARDVTQRHE
NEQM----SLAVAQSPVSIMILDTDYRIEYVNEAYSRLSGYTGQELLGRSPTELWSPRMAESVQPAIRARIARGEPWKGELVSLDKAGREFTESVLIYPV
RNADGKVTNYLSLKENITEKKQAAARIQQLSHYDQLTGLPNRMLLHEHFQYA----SQQFRALAVLWIDLDRFKDINDSLGHRAGDALLQEMAHRLRTAL
RAQDILSRLSGDDFLAILPGA-GQEAARGAQALLDAVALPLRLDGQETFVTASVGIALYPSDADQLDILLKHAETAMYRVKSDGRNGSCFFTPEMQARSA
RLIALGHALKQAQQRGELRLVYQPQLRLSEHRIFGAEALLRWDSPQWGAVSPAEFIPIAESSGLILSIGDWVLRTALRQVRHWLDRGLPDLVVAVNLSAV
QFDQPDLPDRISRMLDEAGVPPHCLELELTEAAAMKTPETAAQKIQELHQRGIRLAIDDFGTGYSSLSYLKRFKIHKLKIDQSFVRDIDSDVDDQAIASA
IIQMARSLSMGTIAEGVETAEQLAFLRASGCDDIQGYHFSRPLEPDAFEHFVLRDV----
>tr|H0C2V9|H0C2V9_9BURK Putative uncharacterized protein OS=Acidovorax sp. NO-1 GN=KYG_20103 PE=4 SV=1
------------------------------------------------------------------------YRALEKSDRSLRAVLDAVPDLMFEVTQD
GRYVQLHTRQPELLLMPADQVLGRS---IHDVLPHEAAAVAQAAINAASAQGVARDFQYSL-DLPGGKRWFEFSVARKVLDEDAEAHFVVLSRDITQRVE
TLDT----RHAVEQAPNSIFIANAAGNIEYVNPAFSATTGYAPEEVLGRNPRLLSAGSTPPSVYQELWAHLACGRPWRGEFLNRRKDGSEYHESAIISPL
LDEQGDITHYLAVQEDVTERKRDEERIRRLVNFDALTGLPNRTMFASRFSQALGLTQRSGQHLALLYLDLDHFKNVNDSLGHQVGDELLVEIARRLQAML
REEDTVSRQGGDEFIIVLPLT-DQQAAHVAEKLQLEVRRACNLGGQELVVTSSIGIAVYPEDGHEFEILAQRADAAMFRAKETGRDCYQFFSSDMQDRSL
RMLHIENALRSAVVLNQLALHYQPQISLRDGKLVGVEALLRWQHPELGTINPAEFIPVAESSGQILGIGEWVLRTALTQARDWAAAGHRDITVAVNLSMV
QFRHAGLVEMVEQALAESGVPPRMLELELTESIAMDDPEKVIAIVGRLCDLGVRLSIDDFGTGYSSFSYIQRLRVHTLKIDQSFVRDLAEDGSAQHIVRA
IIGLAQSLALETIAEGVETAEQQKVLQTLGCDTGQGYHFSRPVPPAQLESFLRGQH----
>tr|C5T198|C5T198_ACIDE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax delafieldii 2AN GN=AcdelDRAFT_0678 PE=4 SV=1
------------------------------------------------------------------------YRALARSEKSLKAVLDAVPDLMFEMTRS
GRYLRVHTRVPGLTERVPEQIAGRT---IDEVLPPDAAGVVRTALTQAEATGHTQGQQFAL-EMTDGRHWFELSVARIQDPGFADPRFVVLSRDVTQRMQ
DLDA----RHAVEQTPHSIIITNLRGQIEYVNPSFTTVTGYGSDEVMGRNPRMLGAGKTSAEVVAQMWERLLSGLAWKGELLNRHKTGREVWEYVSISPM
RDEQGAITHYISVQEDISERKSNEERIRHLANFDALTGLPNRAMFSARFSQALGLSQRSEGSLALLYLDLDRFKNVNDSLGYAVGDGVLIDVAHRLKALL
RDEDTVSRYGGDEFLVVLPLT-TQGAVHFAERLHGELSKACQVESHALLVTFSVGIAMYPGDGSDMEALTHHAEVAMYKAKEMGRDHYCFFSADMQAQSS
RLLRIENGLRTAIAQGEMSLHFQPQWRVHDRRMVGVEALLRWTHPELGVVGPAEFIPVAESSGQIIDIGLWVLDTALACLRRWRDAGHTDLTVAVNLSLA
QFRHPDLVEVVQKALQRAGVPAEVLELELTESIAMHEPEKAIACVRALADLGVQLSLDDFGTGYSSFSYLQRLRVHRLKIDQSFVRNLDTA-RGMSIVRA
IVEMSRSLGLATIAEGVETPHQLEALAGLSCDMVQGYHLSRPLPVPALEALLEQRA----
>tr|K0I066|K0I066_9BURK Uncharacterized protein OS=Acidovorax sp. KKS102 GN=C380_13755 PE=4 SV=1
------------------------------------------------------------------------YRVLKQSDKAMRAVLDAVPDLMFEVTRD
GRYVQIHTRQPELLLMPASEVVGRS---IHDILPPAAAAVAQAAINAAAEQGLARDFQYAL-DLPDGQHWFELSVARKVMDDEGDDHFVVLSRDITQRVQ
MLDT----RHAVEQAPNSIFIAGADGNIEYVNPAFTATTGYSPEEVIGRNPRLLSAGATPASVYADLWAHLTSGRPWRGEFVNRRKGGGEYNESAIISPL
HDEQGRITHYLAVQEDVTERRRDEERIRKLINFDALTGLPNRTMFASRFSQALALTQRSGHQLALLYLDLDHFKNVNDSLGHQVGDGLLIEIAHRLQSVV
RDEDTVSRQGGDEFVIVLPLT-DQQAAHVADELQAQVRRICKLEHHELVVTSSIGIAMYPEDGGDFETLAQRADAAMFRAKESGRDTYRFFSADMQARSL
RVLQIENALRSALVLGQLTLHYQPQIRLKDRRLVGVEALLRWTHPELGAVSPAEFIPVAESSGQILGIGEWVLRTALAQARQWRDAGHTELVVAVNLSMV
QFRHPGLVDMVGRALADSNVPPQMLELELTESIAMDAPEQVIAIVRQLYDLGVQLSIDDFGTGYSSFSYIQRLKVHKLKIDQSFVRHLGEDPSAPHIVRA
IIGLAQSLDLETIAEGVETVAQRDVLLGLGCDTGQGYHFSRPVPAADLQGLLTQGH----
>tr|E1VG88|E1VG88_9GAMM Uncharacterized protein OS=gamma proteobacterium HdN1 GN=HDN1F_02470 PE=4 SV=1
------------------------------------------------------------------------FDHLHASQEQLKATLSALPDLLFEVDQD
GRYVDFHTSQDDLLFVSPKDFLGHT---YDEVMPPAISAIIRKALQEASVQGISRGHQYAI-DLPMGTRWFEASVSLKSTDSSGNQRFIMLTRDISERIE
ANMR----SHAVEQSPLPIIITDINGHIEYANPAFSTVSGYSTDEVIGKNPRELQSKRTQESVYVELWQTLLKGQTWKGEFVNRRKNGEHYVARAIISPV
RRPDGSVSHYVGITEDVTEKKRTEAHIHKLAHYDPLTGLANRVLLVDHFDSALALAQRHSLPLALMFMDLDRFKIINDTLGHSVGDEVLIHVAKQFKTSI
RDEDTVARRGGDEFVFIFPGI-NQQARNVAQKLSRSISEPFRSEHQELNITSSIGIAMYPDDGGDFETLARKADVAMYRAKQNGRNQFAFYTQEMQIHSL
RILQLGNGLRHAIERNQLYLVYQPQICLERSEICGVEALVRWRHPEWGEISPGEFIPVAEETGAISQIGEWVLQTALQQAAEWVKRGLPAIKVAINLSAL
QFRNSNLPDRIQASLEEYQVPASQVELELTEGTAMEDPLGAIEMLKNLHALGIQIAIDDFGTGYSSLNYLKKFQVSKLKIDQSFVRDISVDQEDRAIVTT
IIHMAESLGFRTIAEGVETHEQLTFLREHGCDEVQGYYFSKPLLPAQFEFFLEQWT----
>tr|Q47IR9|Q47IR9_DECAR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (strain RCB) GN=Daro_0505 PE=4 SV=1
------------------------------------------------------------------------FREMKLER---------IPDPVFVKNAN
GVFMSCNKAFERLLGAPEKSILGKT---DYDFFDKDLAD-FREKDRAATAAGRPLSNEFE------------TTKTPLYL-DGQAIGTLGIAHDITRRKR
IE----ADAAAFES--TAMLVTDANGVILRVNQAFLRDTGYAVEECVGQTPRILRSGRHDPAFYQKMWESIRSSGVWQGEIWDRRKDGSIYPKWLTISAV
LGDSGEVTHYIGLHQDVSERKLAESRIHQLAYYDQVTGLPNRILLQERLSQVMAKCRASSNYGVLLFVDLDNFKTLNDTLGHNVGDLLLKQVGEVLRRCS
RESDTVARLGGDEFAVIMSELGTQGAEAAARYLLSELGRTFQLGNVIHRNTVSIGATLFKGEQ-SIESLMRQIDLAIYQAKGAGRNTVRFFDPSMEIALR
ERAAIEEALRYAIEEEQFLLHYQAQIGE-DGRIEGAEVLLRWQHPERGMVSPAIFIPLAEETGDIVLLGSWVLKQAAAQLARWAESPMAGLVLAVNVSAV
QLRQPDFVEQVTTVLREAGADPGRLKLELTESMLVNDVEATIAKMQSLKAIGIGFSLDDFGTGYSSLSYLKRLPLSQLKIDQSFVRDVLVDANDVAIASS
VVALAKSLGLGVIAEGVETEAQRELLAGIGCHCYQGYLFSRPLPIGDFERLVSGA-----
>tr|A1SSA6|A1SSA6_PSYIN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Psychromonas ingrahamii (strain 37) GN=Ping_0516 PE=4 SV=1
------------------------------------------------------------------------YHNLELAKTQLREKKRLIPTAIFLKDVN
NLRLSLINKSTEKLFHSRETILGQS---DYDFFPKEQADFFTNK----DRETIERRTLEII-DTPFGSRTLYTKKIIITDEHNNPKFLLGISEDITERNA
AKKALEES-----Q----LIHPDDR----------SRIDHYFKEDVLNQKKSFNQEYR--------MKRQNDQAVRWVHGL---------------GELE
FDNQGSPILMKGTIQDITERKLAEAHLQALANFDQLTGLPNRFMLKDKITYLFTLARRNNESLTMMFLDLDHFKNVNDTLGHVIGDRLLIEIAKRLKSAI
REVDLVSRIGSDEFILLFPNT-DDSALNIATKLIETVSLPTVFEHHELFITATIGIAIYPNDGEEFETLIKNADTAMSQAKRYSRNTFHFFTEEMQVHLQ
RKLKIVNAMRHALLRNEMQVHYQPQISAVKGHIIGAEALLRWRHPELGDISPGEFIPIAESSGQIVAIGEWVLRTAIDQMKVWQNEGLAPMVVAVNLSAL
QFKQANLIGMIISMLNKAQLAHQYLELELTEAITMDDPQQAINIMNQLHAKGIRMSIDDFGTGYSSLSYLKQFKVYKLKIDQSFICNLARDSDDRAMVHA
IIDMAKNLGMQTIAEGVETAEQLEFLRLHGCNEIQGYYFSKAIPADEFSRFAKQGP----
>tr|G7ZF77|G7ZF77_AZOL4 Putative diguanylate cyclase protein, sensory box/GGDEF domain OS=Azospirillum lipoferum (strain 4B) GN=AZOLI_p30269 PE=4 SV=1
------------------------------------------------------------------------YEALHQSERDLWREK--IGDGLIATDTA
GRVTLMNPVAERLTGWSSGEAVGRP---VTDVFDIENAQTVPVPVQQVLEIGQLVGLT--------------IAASPIRDRDGTLHGVVMVFQDVTETYA
SREALKDSTGILES-ACGIIATTLDGIIRVFNREAERIFGYPADEMVGTASRLYDGECAAPAGFEALDGDLPDSGEWTG----LRKDGARIALSAATSVL
RDSGGAVRGYLTVVMDVTERKRAERQIESLAYYDPLTNLPNRRLLLEQLDGQLRTARQNGRCGALMFLDLDDFKGLNDARGHVAGDTLLRELAARLNATL
RRDDLVSRLSGDEFVILLPDLGEEIAWRVAEKLRLAVAQPFRLDRYEHSIFASIGLTVFPKSAETVEDLLKQADTAMYAAKDGGRNTIRDYDPAMLVDAR
ARLALQQDLRKAVDAGEFTLFLQPQTSA-DGTLVAAEALIRWQHPQRGFVAPGAFIAVAEESGLILPLGDWILMEACHVLRRLADAG-SDCHLSVNISPR
QFRQQNFCAGVIAAVRASHIDPRLLTLEITEGIAIGDCADTVAKMSELAAVGISFSLDDFGTGFSSLSYLKQLPVGELKIDRSFVQDVDRNSHNAVLVET
MLSIASRLGLKAVAEGVETAAERDFLRDHGCAIFQGYYFDRPMPVDDFMRKYVVPA----
>tr|H3ZEJ5|H3ZEJ5_9ALTE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Alishewanella jeotgali KCTC 22429 GN=AJE_08897 PE=4 SV=1
------------------------------------------------------------------------FRKLSLSS---------VPDLLFDVDLN
GRFYQAHTGQNQQLLFQPEHFLGKT-----------MAE-LPESAAS---AGQQAIRAYTL-DLNGEIQWFQVILKPA-SRDSVLPRFVLAARNITEQKL
AQ----ATALAFHT--EAIMITDAQRRIVRVNPAFTEITGYSEQDVCGKTPAILRSGLHDEQFYQQMWQQLYQQGVWSGELYNKRKNGEIYPEQIIINAI
TGSNGEISHYIACFNDISASKSDQQRIYKLAYYDPLTQLPNRRLLLERITDIQHEADRNGFYAALLFIDLDHFKRLNDTLGHSYGDELLQQLSTRLQHSL
RQTDTLARPGGDEFILLAPTYKAADAQQLAAKLLTQIREPFLLKNRQYQITASIGIVLFNSSN-TTDELMSSADLAMYHSKEQGRNQLYFFEPGMQQRSL
LRQQLESEMHLALSQQQFKLFFQPKVNN-KGKLTGYEALLRWLHPERGMISPEQFIPVAETSGFITVLGQWILAEACNALKHLTD---PQLTIAINVSKR
QLQTPDFVAQTLLQIKTAGVKASRLEFEITESMLMTDVEQTRHKLQQLNQQGIRFALDDFGTGYSSLAFLKNVPIQVLKIDRSFVRDFLSDQTDYAIVDT
IISMAKTLKLTVVAEGVETTEQFKMLSWLKCDLFQGFLFGKPAPGFCQPQPIEQLL----
>tr|I9P114|I9P114_9ALTE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Alishewanella agri BL06 GN=AGRI_10808 PE=4 SV=1
------------------------------------------------------------------------FRKLAASS---------VPDLLFEVDLD
GRFYRVHTGQNQQLLYSPEFFLGRT-----------IAE-MPDSARQ---AGELAIAAYAL-EIANKMEWFQVILKQE-AISNHRPRFVLAARNITEQKI
AE----ANALAFQT--EAIMITDAQRRIIRVNPAFTEITGYSEHEVCGQTPVILRSGLHDEHFYAELWQTLEHNGVWSGEIYNKRKNGEIYPEYIIVNAI
HDEKGQVTHYIASFNDISALKSDQERIYRLAFYDPLTQLPNRRLLLERINEVQHECARTGHYAALLFIDLDHFKRLNDSLGHSSGDELLKQLASRLNPTL
RQTDTLARPGGDEFILLAPCYKTADAEKLATKLLQLIREPFKLEQQQYQISASIGIALFNDNS-NTDELMASADLAMYHSKEQGRNRWYFFEQSMQHRIL
LRQQLEAEMQTALQQQQFKVYFQPKVDG-SGKLTGYEALLRWQHPERGMISPDEFIPIAEQSGFIIELGHWVLMRACQALQQLSD---SSLVIAINVSKR
QLQTDDFVESTLAAVLSSGVPASQLEFEITESMLMTDVEHTRDKLEKLHRQGISFAVDDFGTGYSSLAFLKNLPIQVLKIDRSFVRDFLVDQKDYAIVDT
IISMAKALNLTVVAEGVETVEQFNMLSQMRCDLFQGYLFGRPAADFAAPTLLQATE----
>tr|H2CHJ4|H2CHJ4_9LEPT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptonema illini DSM 21528 GN=Lepil_0106 PE=4 SV=1
------------------------------------------------------------------------YRILEMER---------IPDPVWLKNEA
GVYLACNAAFGRLVQRTEEQIIGRR---DEDLFGESLGI-YRRRDRMALEQGRPVRNEYE------------TTKTPMYLSDGELIGILGIAHDITEIRE
AE----KEAKTFEA--IGLFITDASQRILRVNPAFTQITGYTADELIGKTPRIFQSGRQNRSFYSAMWKEINEAGVWQGEIYNRRKNGEVYPEWLMISQV
KGAAGEVTHYVASCSDLSENKAAAETIERLSLYDPLTELPNRKLMMDRLRQLIASVEERRRQGALLLLDLDDFKVINESYGHTVGDSLLVEAGKRLKSVL
HGGDTVSHPGGDEFIVILDNLDRQAETT-ALRLQEALSRPFVLEDASYYCSTSIGVVLFTDSA-SPDELLKRCDTALYSAKSAGRGHVRFFDMQMQATVV
NRSSILEDLHRAVREGHLFVQYQPQVNE-SGRVIGAEALVRWRHPVSGVIPPGRFIPIAEESGLIVAIGQFVFETACRQLALWKNDEFSHLTLAVNISAQ
QVKVPHLTRWVKRLLNETGALPEKLKLELTESMLFSDTDEVIERMNELKAIGLKFSLDDFGTGYSSLSYLRRLPLDQVKIDQSFVADLLHIQANQAIART
IIQLGENLGLTVLAEGVETEEQRDFLVGHGCRAFQGYLFSPPLDLEEFEAYVGRSS----
>tr|R4YJD6|R4YJD6_OLEAN Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor OS=Oleispira antarctica RB-8 GN=OLEAN_C00810 PE=4 SV=1
------------------------------------------------------------------------FLSLARD----ANTYDAVPDETIVVDRD
GYVRQVNEAVRRNL-DHPENAIGSR---CHALQHDPKITEQDCQICRCIRVGEALA--SEY-FIESQQQWFEVILSKISH-GDNSLAMVHVRRNITVAKD
AQARSEIFSQVVEQNAHAILITDINFKIEYANRAFTALTGYLQQELVNKTPAILRSRYTDNDTSSDINRTLKAGREWSGQVRNQRKDGSLYWALQSIIPI
KSDDGEITHYVSTSEDNTDLHNAQQTIEQLAFYDPLTNLPNRRLLSDRLQQALEHAQRNPEMVAVMVFDLDNFKTVNDSLGHNYGDDLLKHVAQIFQSQI
RSEDTVSRQGGDEFTIVLAGMKQEKIADIADTILQKLSHPINLSGHQVVIGSSIGIAVYPNDADSHDELLRNADMAMYHAKEEGKNNFQFFMPTMNKQAH
HRLLLENKLRNAIEKNHFQLFYQPQLDLKTGDVVGTEALIRWFDPEQGMISPAEFIPLAEDTGLIGQIGDWVIDAACRDMKALQAKGFPQVKVAINVSAF
QFRHGKLTEVIRQSLEEHDYPAKLFALELTESILIDDVNETLNILNSMRDLGITLAIDDFGTGYSSLSYLKQFPIDILKIDQSFIRDITTDASDKAIVSA
IIAMAQQLDIDVLAEGVETLEHQAFLQSQGCDYVQGYLYCRPIPADELFDHWQKKQ----
>tr|A0A091BID7|A0A091BID7_9GAMM Uncharacterized protein OS=Arenimonas composti TR7-09 = DSM 18010 GN=P873_00215 PE=4 SV=1
------------------------------------------------------------------------LRQLERSGQTIRDQQ--LPLGISRIDRE
RRFRYLNPSRARLLGADPDQVIGHR---VDEVLGAETLAVVEPHLARAL-AGESARFA----RADGAVLNLSVVLVPEPGSDGGVEGVLCIFSDDSERHE
AQSALLGTSDLKAAAHAIVAVTDARGVIQRVNDKFCAISKYARDELVGQTHRLINSGTHPRAFFVDMWRTIASGRVWNGEVCNRAKDGSLYWVHTTIVPF
IGGNGLPEQYIAIRADITARKQAEEAALRLAFHDPLTGLGNRRMMQDRLRRGLAQSRAHRRYGALILIDLDEFRAVNDTLGHEAGDALLREVARRLGECA
READTVIRLGGDEFVLVLEDLGETRVAEISELVRRVLDQPYVIDSIRVDAPPSAGVVMLDGGI-QEEDALKQAELALYKAKSAGGNQVVFFDPALQQDVN
ERAGLLADLRDALELGQLRLHLQPIVAG-DRRVLGHEVLLRWSHPQRGLVSPASFIPLAEQSGLILPIGQWILESTCTLLAAWAADPKSQWTLAVNVSAR
QFHDPGFGDSVLLALHRSGADPRRLRLELTESMLHTDLAETAARMERLQREGVRFSLDDFGTGYSSLAYLQRLPLDVLKIDQSFVREITTRASDAVIAET
IVSLGKSLRLRVIAEGVETEAQFEFLRGLGCDGFQGWLTGRPVPAEE-------------
>tr|U3B1Q1|U3B1Q1_PSEAC Uncharacterized protein OS=Pseudomonas alcaligenes NBRC 14159 GN=PA6_028_01040 PE=4 SV=1
------------------------------------------------------------------------YQRMALSEQRIRTQE--LPSGIARLDAT
LRLRYLNPALANHLTRSSAEALNNP---IADALPGDIQQQAMPYLLKAL-SGERSGFL----TASGQQAWALASVIPEKDAEGRANGVLAIVTDTTERER
TRRDLAKSSDIKAAAHAIVAITDARGVITQVNNKFCSISQYSRSELIGRTHQLINSGHHPRTFFQDLWRTISRGQVWNGEVCNRAKDGSLYWVYTTIVPF
IGEDGVPVQYIAIRADITQRKLAEQEAEHLALHDSLTGLPNRRLMIEQLGQRRALLQASHHIGALLLLDLDNFQEINDTLGHAQGDELLRQVARRLQQQI
RDDDRAARLGGDEFVLILADLGTTLLEAFSERLRESLAQPFELQGNEVMITASLGAVLLHPFC-AEEELVKQADMALYRAKEAGRNRLCLFEARLQEDVT
SRVLLLRDLRNALPRQELELHYQPLVNV-QRQLVGVEALLRWRHPQRGMVSPLEFIALAEQTGLILPIGDWVLEQACQQLRRWAERECRHWSLAINVSAR
QFAEADFADKVIAALARHDANPARLRLELTESLLHSDLEATIARMERLRQEGVRFSLDDFGTGYSSLSYLKRLPLDVLKIDKSFVDDLLTDANDAAIART
ILALAGALELKVVAEGVETEEQFAFLSAQGCQTFQGYLFGRPQPAEVLLAGLDAAP----
>tr|F5RD40|F5RD40_METUF Diguanylate cyclase/phosphodiesterase OS=Methyloversatilis universalis (strain ATCC BAA-1314 / JCM 13912 / FAM5) GN=METUNv1_021
------------------------------------------------------------------------YELLRLSEAGLRARK--VPVGIARIGQD
LRVGYANRVCAGLIGLPEDALVDRP---VEQAFPPFLLQPLQPALMRAL-AGERVEFA----EGAG--LHLAVTLVPEPATEGQPRSLLIMLSDTTERER
ARRHWLESRELKAAAHAIVAVTDARGVITRVNDKFCQISQYPRDELIGCTHKVINSGHHPRSFFDDLWRTIASGQVWHGDICNRAKDGSLYWVHTTIVPL
SHADGQPAQYIAIRADITERKRAEEEAQRLAFHDELTGLPNRRLMSDRLRHAIDGADRDHQYGALLLMDLDNFKEVNDTLGHAQGDALLRQVSSRLLARL
RASDTVARFGGDEFVVIVEELGAIRMGHICEALREALAQPCELGGQMVGSTVSMGVVFFRDAR-DPDELLKQADIALYKAKEAGRNRVCFFDPGLQAETT
RRATLLRELRGAGARGELELHYQPVADA-RWRILGVEALLRWRHPERGMVPPGVFIPLAEQSALILEVGQWVLETACAQLAAWAHDPRACWTVAVNVSER
QFHDPAFLHKVEKALADTGADPHRLRIELTESMLHRDLDMTLQTMRALQQRGVRFALDDFGTGYSSLSYLKKLPLDQLKIDKTFVDEVLSDANSAAIART
ILSLAASLELGVVAEGVEKAEQLAFLARHGCPAFQGYLLSRPKPVSELPPVLERPA----
>tr|Z5XLV8|Z5XLV8_9GAMM Diguanylate cyclase OS=Pseudoalteromonas lipolytica SCSIO 04301 GN=AT00_14360 PE=4 SV=1
------------------------------------------------------------------------YSMVNKAELYASKKK--MNIGVLRLSAD
FKLSYYNQNALKTYFYLRTPIQGKY---IHDVFPPDVIDKVLPFLRTAL-KGEQVKFI----GLDEETLFLDVNVIPENDKSEKVISLLCLIENMTEMKL
AEKENEELAELKKAQHAIVATTNSKGVITSVNEKFCNISQFSAAELIGKTHALVNSGTHPPRFFKTMWQTIRSGQVWSGEVCNRAKDGSLYWVNSTVVPF
IDENNKPYKYIAIRADITDRKLAEQNVHRLAMYDELTNLPNRRHLIDKAKSLAKKHHTQGHSYALLLIDLDNFKMINDTLGHSIGDLLLKEVSRRLESIV
LSPNLIARLGGDEFVILLDDPTCHSVDSFAQNIRETISRVFYLDGYEVHTTPSIGLTIINACD-ELSEALKQADIAMYHSKERGRNMISFYDPKLQASIL
ERNEINQGLINAIAKKELNVVYQPIHNT-SKELIGYEALLRWDSPKLGSVSPDVFIPIAEETKQINQIGQWVLEQVCEEMSKNDA-YNPNLSVAVNVSAL
QFQDPNFVPQVLETINRFSIQPSRLKLELTEGVILMGTEMLIKRMKDLKNLGINLSLDDFGTGYSSLSYLTRFPIDTLKIDKSFIDKMLISSEDESVVKA
IFTLATSLGKNVIAEGVESEEQFQYLKRLGCQFFQGYLLGKPQSFNHRE-----------
>tr|K0I8A9|K0I8A9_9BURK Diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. KKS102 GN=C380_18775 PE=4 SV=1
------------------------------------------------------------------------FARIQEAESRLRESEGRVPGGVSRIDRD
LRVLYVNEQQARWLYTTPQALEGQL---LRDVIPPEVFARIHPHLEKAF-AGETAVFN----DGPDGTQFRHTTIAPESVTAQGVAAVVLFAYDLTALKR
IEQELAQQASVVNA-PDMVFMKDTNGVYLSVNPVFERFAGRPESQVVGCSDFDLVAPADAERFRKYDQRAMQAWQLVYEETLTFAEDGYQGQFETIKTPI
RDLHGRVTGILGVCRDITDRKRAEQEIERLAFYDALTGLPNRRLLLDRLQRSIAACQRTRNLGALLFIDLDNFKDLNDTLGHDMGDQLLAQVAARLVGSV
READTVARFGGDEFVVMLEALAPTQAETVAEKLLASLNQPFNLDGAQHYSTPSIGITLFGDER-TVDELLKRADLAMYQAKAAGRNTQRFFDPDMQAAVN
ARSNLEADLRQGLARGELLVHYQPVVDH-HARLLGAEALVRWRHPQRGMISPADFIPLAEQTGLILPLGQYVLQTACEQLQRWSQHPTAHLSISVNVSAR
QFRQPGFVAEVLQTLKNHNADPRQLKLELTESLLLGDIEDTIARMVQLKSEGVGFALDDFGTGYSSLSYLKRLPLDQVKIDQSFVRDVLTDPNDAAIVRT
ILALAKSLDLEVVAEGVETTGQLSFLRLHGCEGFQGYLFGRPGPVELFEREYLPGH----
>tr|N6Y6B4|N6Y6B4_9RHOO PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thauera sp. 63 GN=C664_16910 PE=4 SV=1
------------------------------------------------------------------------FDLLFRSLKQKETELESSPAVIYLTDLD
CRYTLANAAFERLVGRPRREILGKT---AFELFPQDVAFRLDRRNH----NVIATNQPVGT-SQQGETRHFKSVHFPLQD--------------------
--------GAIIRSSMDAFMMVDEEARLLEVNDAACELSGYTREELLRLRVSDLDTAVDEPKLQAAMHNIARDGSSRI-DSRWRRKDGELRDV--ELSVQ
CLVHGGVPRYYCFVRDISGRKAAAARIEYLAHHDLLTALPNKLLFQQQCHAALLNAEREGRNCALVYLDLDDFKAVNDTLGHAVGDALLCELAARVRTLI
DEHGLACRVGGDEFLVLVGDAGNQRLAAFAERTLALLAEPVQLDGTFQTCTVSLGIARFPNDGTDFDTLYRKADMAMSQAKTAGRNTFRFFDEAMHAQLV
ERRHLLSLLRGALERHELRLHYQPQIDLHTGEVIGAEALIRWQHPELGVVSPARFIPIAEESGLIVPIGNWVMREACRQAKAWQDAGLPRFVVAVNLSAV
QFRLPDFCQTVADALTDSGLSPDCLELELTESLLINDADGVLETVRELKALGLQLSIDDFGTGYSSLAYLKRFDVDKLKIDQSFVRDMDRDADSAALVLA
IVQMAHSLGLKTIAEGVEHEHLAAALRSLNCDEAQGYHFARPMPAGDFEGWLRNVV----
>tr|A0A0A1H8V8|A0A0A1H8V8_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Burkholderiales bacterium GJ-E10 GN=E1O_26430 PE=4 SV
------------------------------------------------------------------------INLLLRDLRQTEARAA-AGDGVHVFDSD
GNVLEVNEKFCSMLGYARAEMLGMN---VAQWDARFSPEEIGAKI-LRHDTVFETRHR------RKDGSIFDVEISARAIDFDGRTVIWNASRDVTERKR
TERRLQLAANVFTHAREGIMITDAAANIIAVNSAFSTITGYAAEEVIGRNPRMLQSGRQGPDFYRAMWQGILEHKHWSGEVWNRRRGGEVYAEALTISAV
LDESGHVQHYVGMMIDITLVKEHERQLERMAHYDALTGLPNRVLLTDRLRQAIAHAQRHDNLVAVAVLDLDGFKAVNDRYGHAVGDEFLIAVAHGMNMVL
REGDTLSRIGGDEFVAVLADLDRVDCEPVLLRLLAAASRQITVDGRLLQSSASIGVTIYPSDGEDPDHLLRRADQAMYSAKQGGKSRYHFFDAAQDNVIR
AQRQWIDRIEAGIERDEFVLHYQPKVNLRTGAVVGAEALVRWRHPERGLLPPSEFLPPIEGHQAGIRMGEWVLGSALRQIGDWLARGL-RVPVSVNLDAP
QLLQPDFLARLAAQLNHADVDPDLLELEILETSALENIARVSEVMHACVEIGLRFSLDDFGTGYSSLTYLKHLPVEVIKIDQSFVRDMLEDAGDRALVEG
VIGLAKAFHRTIIAEGVETAEQGRALLGFGCELAQGYGIARPMPAERLPEWITEWA----
>tr|I4Z5F7|I4Z5F7_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Leptothrix ochracea L12 GN=LepocDRAFT_00001790 PE=4 S
------------------------------------------------------------------------LHLLFRELSQKEAELEAASDGITIMDRN
ANIIEVSDSFCDMLGYTREEMIGMN---VAQWDCGFNSHEETMAVEQQTRALFETRHR------RKDGSTYDVEISGYPIELDGTMVLFNSSREITERKR
AEQKLQLAANVFAHANEGIMVTTPSGVIVEINETFTRITGYSRDEVVGQTPRLLSSGRQSREFYDSMWRALIDKGHWSGEIWNRHKSGEFYATMQTISAV
RDAQGKTLQYVAMFSDITTLKEHQNELEYIAHYDALTHLPNRVLLSDRLHQAMTQSVRRKNRLAVAFLDLDGFKAINDQHGHAVGDQVLVAMAVHMRQAL
REGDTLARLGGDEFVAVLLDLESEASGPLLARLLDAASQPLRVDDLDVRLSASLGVTFFPQAQDDADQLLRQADQAMYQAKLAGKNRYHVFDAELDQSVR
GHHESLERLRQALNANEFVLHYQPKVHMRTGQVIGAEALIRWNHPTRGLLFPAQFLSVIEGHALSIHLGEWVLNHALTQIEQWHASGL-DLKVSVNVGAR
QLQQADFAERLRVILAHPEVKHGQLQLEVLETSALDDITWTANVIESCRKLGVTFSLDDFGTGYSSLTYLKRLPVVELKIDQSFVRNMLEDPDDLAILNG
VIGLANAFNRQVIAEGVENVESGTLLLKLGCELAQGYGIARPMPGPDMPAWCLAWR----
>tr|F0QCU1|F0QCU1_ACIAP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM 20985 / N
------------------------------------------------------------------------YARLREAESRLRESESRMPGGISRLDRD
LRILYVNPSQAQWLRRTPQELEGRR---ASEVLSAELVQSLHPHMLQAL-QGRPVVFY----FRGEGPEFFHTTIIPETGPDGRVVAIMVFAVDVTEQKH
LALELSQQASLVNA-PDVVFLKDASGRYLSCNPVFERYLGRRERDIVGLGDEELMTPIEAARVRQLDERAMAAWQVVYEETLTFAEDGYAGYFETIKTPI
RDMHGHVTGLLSVSRDITDRKKAEQQIELLAFFDALTGLPNRRLLLDRLQRAGAACQRNEKLGALLFIDLDNFKDLNDTLGHDMGDRLLVQVAQRLQECV
RTSDTVARFGGDEFVVMLEGLDALQAEQVAEKLLAQLNRPFEMGAQQHYSTPSIGITLFGDQR-SVDELLKRADLAMYQAKAAGRNTQRFFDPDMQAQVT
ARSQLESDLRQGIARQELTVHLQPIVDG-STRLCGAEALVRWRHPVKGLVSPADFIPLAEETGLILPLGRQVLQTACEQLVRWAAHPTAAFTIAVNVSAR
QFRQPDFVAEVLGTLAATGANPQRLKLELTESLLLGDVEDTIGRMAQLKRVGVGFALDDFGTGYSSLSYLKRLPLDLVKIDQSFVRDVLTDPNDAAIVRT
ILALAKSLDLQVVAEGVETAGQLSFLKLHGCEGFQGYLFGRPVPMETFEREHDLPV----
>tr|A0A0A1VDI9|A0A0A1VDI9_9BURK Uncharacterized protein OS=Acidovorax sp. MR-S7 GN=AVS7_01306 PE=4 SV=1
------------------------------------------------------------------------YERARQAERRVRESGLRLPGGVSRVDRQ
GRVLYVNPLQAQWLRCAPSALEGQL---LSDVLTQPFLSRLDPPLQRAL-RGETTTAV----EGPDGPVVWRITFVPERAG-EEVSSVVIFAYDITEQKR
LAHELRQQAGLVNA-PDVVSLKDAQGRYVSGNPVFARFLGRSEREFVGLTDAQLLPAGEAQRVQALDQRAMAAWQLVVEETLTFAEDGYSGRFETVKTPI
RDQHGRVTGVLSVCRDITDRQRAAQEIERLAFYDPLTGLPNRRLLLDRLEHAMAACERHGRLGALLFIDLDNFKDLNDTLGHDMGDRLLAQVAQRLVECV
RESDTVARFGGDEFVVMLENLEPGQAERVSEKLLARLNQPFDLGSQQYFSTPSIGITLFGEQR-SVDELLKRADLAMYQAKAAGRNTQRFFDPDMQAAVN
ARSQLEADLRQGLARSELSVHFQPVMDE-RTRLCGAEALVRWRHPERGMVSPAEFIPLAEQTGLIVPLGRMVLRLACEQLVRWSHHATRGLSISVNVSAR
QFRQPDFVADVLGTLAETGAQAGLLKLELTESLLLGDVEDTAQRMGLLQQQGVGFALDDFGTGYSSLSYLKRLPLAQIKIDQGFVRDVLADPNDAAIVRT
ILALAKSMDLQVVAEGVESTSQLAFLKLHGCDGFQGYLFGRPCTAEQFEAEHLPEL----
>tr|B3E661|B3E661_GEOLS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Geobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) GN=Gl
----------------------------------------------------------QGYQREQLAKARAVEQALLDARQQLNDIIDFFPDAVFVIDRK
RVTIWNRAI-EKMSGVPKEEMLGKG---DHEYSIGQRRAELAAKYSNIRRVGDAETFCPALHDGKGAYVW--ATGVPLYNAAGERIGAIEAIRDISDRKQ
SELFLKKLTHGIENSASAVVITDTQGVIEYVNKKFIQLTGFSLEEAVGKNPRILKSEATPPEVFVDLWKTILSGREWRGELLNRRKNGEVYWSITSISPL
RNDSGEITHFIANVEDINERKNAEATIEHLAYFDPLTDLPNRRMLQDRLELALRRSRRHGSNVALMYLDLDSFKHVNDSMGHPAGDLLLKEMAGRFSGVV
RDDDVVCRLGGDEFALILHDIHQQDVVPIAQKLIEAVAQPVPLDGREVVVTASIGIALFPRDGGDVKNLEKHADIALYHAKEEGKNTFRFYLEELNSTIS
TRIALEQGLRYAKERQELELHYQPKVCVASGKVSGVEALLRWHSPDFGLVSPIRFIPLAEQTRLIIPIGEWVLRTACLQQVQWREQGL-LLNMAVNLSAI
QLKSPGLVERVAAIIDETGIQPEHLELELTESALVNNPDEVVQLLERLRTLGCSISIDDFGTGYSSLSYLKSFPVTILKIDRSFVRDLAHNSGDRAIARS
VVDLANNLDMKTVAEGVESEEQLTILQQIGCTYIQGFIYSRPVQADQVSAVVRRLG----
>tr|A0A0B1Q162|A0A0B1Q162_9GAMM Diguanylate cyclase OS=Halomonas hydrothermalis GN=PZ78_01005 PE=4 SV=1
----------------------------------------------------------RHYLHR-LALGYQLQ----ARQVRLDALIHSVQDMIFVFDGQ
GRFTYIHALDDKLL-LDSAQALGKS---YAEVLPMPLAQAFDDVFQQVQRTRQVATFEYSLPLGQQ----SHATLSPLVSSTDELEGVLSVTREVTDAKR
AEVELQIAAAAFQ-AHLGIMVTDARGTILKVNDTFKRITGYSDAEVVGRNPRMFSSGHHNAAFYRRLWRSVLSTGSWEGEIWNQRKNGELFPEWLTISAV
HDRNGSLTHYVATMSDISERKAAEQEIHQLAFYDPLTGFANRRLFIDRIGVALKELNRHQRCGALILLDLDSFNHVNDTLGHHIGDRLLQNVARRFGQML
RDTDTLARLGGDEFAVLVEGVDGPRKEHIANKLMAALDTPIQVGDEQASVTASVGITVMADSQRSADDYLQQADMALSQAKASGRRTLRFFDPSMQAALL
ARVRLEADLRLALDHQQWQLHYQLQVD-EQGRIVGVEALLRWHHPERGLVSPGEFIPLLESTGLINDVGEWVLAAACHQLAAWQHQPGFQLTISVNISPL
QFRENDFLDRVEQVFLRTHAPLERLKLEVTETLFVEARDDARDKMLSLKARGVRFSLDDFGTGYSSLAYLAQLPLDQLKIDQSFVQQVLESSANAAIVES
TIALAKSLNLDVIAEGVETPAHQAWLMAHGCHAFQGYLFGRPMPVEEMEQAVRAQR----
>tr|F7SMA9|F7SMA9_9GAMM PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Halomonas sp. TD01 GN=GME_08159 PE=4 SV=1
----------------------------------------------------------RHYLNR-LTLAYQLHAEAQARGARMDALVHSIQDLIFVFDVE
GRFSYIHAVAEQLL-INSQDALGKH---FSHVLPVPLARAFAAVFERVQQFHQVERFEYPLTIDAQ----PHATVSPLISSAGQFEGVLSVNRDITEAKR
AEVELQIAAAAFQ-AHLGIMVADARGNILKVNDTFKRITGYSDAEVIGKNPRMFSSGHHNAAFYRRLWKRVITTGSWEGEIWNQRKNGELFPEWLTISAV
YDADGMLTNYVATMSDISERKAAEQEIHQLAFYDPLTGFANRRLFMDRMEAALKELNRHQRCGALLVVDIDRFNHINDTLGHLAGDQLLQRVAQRFGQML
RDTDTLARLGSDEFAVLVEGVDGPRQEHIAQKLLVALDEPISFAEEHVMVTACIGITIVSDSQRSAEDYLQQVDMALLQAKASGRRAIRFFDPSMQATLL
ARVKLEADLRQALESHHWRLYYQPQVN-RFGHFTGVEALLRWQHPERGMVSPGEFIPLLESTGLINEVGEWVIEDACRQLACWAAMPHLELTISVNISPL
QFRDSDFLSRLQQIFIRTKAPLERLKLEVTESLFVEARDDARDKMLSLKAQGVRFSLDDFGTGYSSLAYLAQLPLDQLKIDQSFVHQVLESSANAAIVES
TIALAKSLNLDVIAEGVETEDQKAWLLAHGCHAFQGYLFGRPMPVDAIEEAFLAQP----
>tr|H0J5Q9|H0J5Q9_9GAMM PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Halomonas sp. GFAJ-1 GN=MOY_14895 PE=4 SV=1
----------------------------------------------------------RHYLNR-LQLEMQLYAEAQQREARLQALVYSIQDMIFVFDSQ
GGVIYVHAIHHRLL-KSVHDITGKH---YSDVLPEEVAKAFSSVFYRVRRHRRAEELEYSLTFEDE----VAATVSPLSDASGGFDGVLALVRDITQAKL
DDVQLRIAATAFQ-THLGMLITDAQGCILKVNRTFTRITGYQESDVLGENPRMFSSGRHDADFYRTLWGNVAKSGSWEGEVWNRRKNGEVFPEWLTISAV
KDNDGVLTHYVATLSDITERKAAEKEIHKLAFYDPLTGLANRRLFKDRLEAMMNARPRNPHHGALLFIDLDNFKQVNDTLGHYAGDQLLQQMASQLQAVL
RETDTLARLGGDEFAVVIDTLNEAEQEGIAQKLLVAIRRPVLLRDETVMVTGSIGITVVDGSAPSVDDYLQQADMALFQAKEAGRDTLSFFDPAMQSELV
QRARLEADLRHALANQQWRLHYQPQVD-RDGVPTGVEALLRWQHPERGMVSPGVFISLLESTRLINEVGDWVLEEACCQLAEWAQQPQYHLEMAVNVSPL
QFREPDFLARTQAVLQRTGAPLEKLKLEVTESLFLEARDDARAKMEALKALGVRFSLDDFGTGYSSLAYLAKLPLDQLKIDQSFVREILQSPANAAIVES
TIALAKSLGLDVIAEGVETGEQQRWLAEHGCYCYQGYLFARPMALSALTQWVSQQK----
>tr|U7NUH8|U7NUH8_9GAMM Uncharacterized protein OS=Halomonas sp. PBN3 GN=Q671_09300 PE=4 SV=1
----------------------------------------------------------RHYLNR-LRLEAEVRQETQSREARLQALVGSIQDIIFVFDAA
GRFVFVHAPDGELL-AAPATLQGRH---YREALPAELAAQLDAAFAELRQGGGPVEYDYRLELAGE----RRSVLSALDDHGPDAGGALAVVRDVTEERA
TEAQLRIAATAFE-THLGMLITDAEGRILRVNDTFTRITGYPEAEVLGRNPRLLSSGLHDEAFYAAMWQAVTRDGSWQGEIWNRRRDGEVFPEWLTISAV
RNAQGELTHYVATFSDLTERKAAEEEIHQLAFFDPLTGLPNRRLLLDRLEGVLRDSYRNGRYGALIFLDLDNFKQVNDTLGHHRGDQLLRSVARRLGAVV
RDTDTLARLGGDEFALLLHDLGEPEGERVAHKLLAALQAPVLLGGERLLVTGSLGVTLFRDHETGVDEVLQQADMALFQAKGAGRNTLSFFDPEMQVRLQ
ARARLEADLRLALPREELLLHYQPQVA-RHGEVVGVEALVRWEHPERGRVSPGEFIPLAEENRLIVAIGTWVLESACRQLARWVADPARHLTLAVNVSPR
QFCEADFVERVVAILEATRAPAERLKLEVTESLFLEARDEARAKMLRLREHGVSFALDDFGTGYSSLAYLKRLPLDQLKIDQSFVRDLLDDETSAAIVAS
IIALARSLELEVIAEGVETEAQRDWLIAHGCHAFQGYLFSRPLPLAELRLLPG-------
>tr|Q0AAF1|Q0AAF1_ALKEH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / M
----------------------------------------------------------AHYLHR-RSLERALREALQSREARLRALVDAMPDLLFMFDRE
GRFIHIHADEEKLL-LPAEQALGKH---FRTVLPEPLSTPLKDALARLAAGEDPVQYDYTLTLGGT----ETTVVRPVRGADNQYLGALAQVRDITEART
TEAELRIAAAAFE-THLGMMITDAEGRIQRVNDTFCRITGYQQAEVLGQTPRLLSSGRHDERFYQRMWAQVREHGSWEGEIWNRRKNGEIFPEWQTITAV
RDDSGEITHYVATLHDISDRKEAERQVHRLAFYDTLTGLPNRRLLLERLAHCLRGNHRSRRQGALLYLDLDHFKAVNDAHGHGTGDRLLQALSGRLSNSI
RESDTLARLNADDFLVLLTDLAETQAEAAAEALIKQLEAPLVMDGEPIHLHASIGITLFRNHETKPEVAVQEAEQAMHQAKQSGRNAICFFDPLMQADML
RRVHLERGLRRAVHDGGLTLHFQPQVG-PDGDILGYEALLRWPHPEQGPIGPGVFIPIAEQSRLIIPLGRWLLQAAARQLAAWARDPATALTLSVNISSV
QFRHDDLVAAVREALETTGAPAERLKLEVTESLLMEEPDQVCATMERLRALGVHFSLDDFGTGFSSLAYLQRLPLDELKIDQSFVQSLEQAPAADAIVGS
IIGLARSLSLHVIAEGVETETQRTRLAAHGCHRYQGYLFGAPAPLA--------------
>tr|H0J0U1|H0J0U1_9GAMM PAS/PAC and Chase sensor-containing diguanylate cyclase/phosphodiesterase OS=Halomonas sp. GFAJ-1 GN=MOY_06235 PE=4 SV=1
----------------------------------------------------------YHYRRL-YAAEKVLRQEVAARK--------------------
--------------------------------------------------------------------------------------------TAQQATEL
EAAQLKIAAMAFE-THLGMFIADADNRIVQVNHTFSEITGYDEKEVVGLTPAMLNSGRHDATFYRQMWLSLNEQDRWQGEVWNRRKNGEVYPQWLTISVV
RNDNGAVTHYVATLSDITQRKAAEQEIHQLAFFDALTGLPNRRLLIDRIEARQREARQESHYSAVMFIDLDNFKTINDSLGHYLGDALLVSVAKRLAGIV
RDSDTAARLGGDEFVVMLHELGDIAVEGVAYKLLTALREPLVIDDHPLQISGSIGVTLFAGESVGVSEILQQADLAMYQAKASGRNALCFFDPFMQAAVK
ERAQLESDLRHVIERQQLSLYYQTQVN-ERGQVVGVEALVRWLHPERGIVSPGVFIPLAEETHLIGMIGEWVLETACRQLVVWSQQPHTALSAAVNVSPN
QFRQVGFVEQIKAVLARTGANPQRLKLEVTESLLMEDIAEVRCRMEALRQLGIRFSLDDFGTGYSSLAYLKQLPLDQLKIDQSFVRDVLEDPADAAIVRT
VIALAHSLELEVIAEGVETQAHRDWLNAQGCLVYQGYFFSRPQPIENLQLPDTV------
>tr|M1FMH2|M1FMH2_9ALTE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Marinobacter sp. BSs20148 GN=MRBBS_3612 PE=4 SV=1
----------------------------------------------------------KQFCRR-LAFENELLQHAQANESRLQALVNSIPDSTFVFDEH
GRFTFAHAQDGQLM-RPVAKLLGLH---YSEVLPPELAARFDRIKTDVEKSQKMQNIEYQLFIDGG----AEARVNPLTDLEGQHSGFLTLVRDITEDKV
LEAELRIASTAFE-THLGIIITDENSIILRANKAFSRITGYAEHDVLGKTPNVLQSGLQDATFYHYLWARVRESGSWEGEIWNLRKDGEAYAEWLTITAI
CGKSGVVQNYVGTFHDITKRKKAERNAHQLAFYDSLTGLANKTLLEERISGVCNANIKHNAHAALLYVDVEQLRAVNDARGYGFGDLVLKSIAEQLAGIV
RESDTLARVGGDEFAILLSSLGSQDVENVADKILDAFALPIEVLEQKIQVSVSIGITMINGRTAVCDQQLQKAEQATQQAKLRGEMRISFFDPEIQAQVV
QHVLLEDELRNALAENQLVLYYQPQIR-KPNRLLGYEVLLRWRHPERGIVSPAVFIPIAEQSRLILPIGRWVIEQACEKLAVWQSEPTTGLSLAVNVSII
QFQSNNFVEQVGQILEKTGAPPGLLKLEVTESLLMNDPERITEMMNRLRSMGVRFSLDDFGTGYSSMSYLNQLPLDQIKIDQSFINEVTNNLANSAIVES
IIGLAKGLNLEVIAEGVETEEQRDWLANHGCQNFQGYLFGRPEEI---------------
>tr|W0SG92|W0SG92_9RHOO Uncharacterized protein OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_02506 PE=4 SV=1
----------------------------------------------------------GFYQRR-QRGLQDIA---QASADRLNEAQRIAQVGNWTLDLS
GELTWSDQ-VFRLF-EIDPARFGAT---YDAFLNPDDREAVHQAYAESLVTRQPYEVTHRLRMNDGRIKWVDAT--------GKPLRSLGTVQDITDGKL
AEIELRIAAAAFD-SQEAMMVTDANSVILRVNRAFVQITGYTPAEAVGQTPRLLQSGRHDKTFYREMWEAINRTGTWQGEVWDRRKDGTVYPKWLTISAV
KDDSGTVTHYIGSHYDITERKIAEEKIRQLAFFDQLTGLPNRTLLMDRLRQTMAASSRSGGHGALLFIDLDNFKMLNDTLGHDKGDLLLKQVAQRLKLCV
REGDTVAHLSGDEFVVVLAGLDASADEAIVEKILASLNQDYLLADVVHHSTASIGITLFMGDPTSIDELMKQADLAMYKSKEAGRNTWHFFDPGMESAVK
ERAALEDDLRLALQEQQFVLHFQAQVV-G-ERLTGAEVLVRWQHPQRGMVPPGEFIPLAEDTGLILPLGEWVLDAACRQLARWATQPELHLTLAVNVSAH
QFGQVDFVDQVLAVLKNTGANPRFLKLELTESLLVDNVQDIIGKMFALKARGVGFALDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDILVDPNDAAIART
IVALAESLGLGVIAEGVETETQREFLAKSGCHAFQGYLYSKPVPLDKFEELMTAEA----
>tr|U5N8G7|U5N8G7_9BURK Signal transduction protein OS=Candidatus Symbiobacter mobilis CR GN=Cenrod_0345 PE=4 SV=1
----------------------------------------------------------LRMLQQAMAREDMLA-------DAYQSILATTLDGYLSLDGR
GQVRDANPTYCRLSKYTRDELLGMR---IHHLTTEDAARTLKHIQEIIEEG--NAQFESIHRRKDG-SLWNV-EVST----TVPGGQFFVFLRDITERKQ
AETNLRIAATVFE-SHEGMIVTDANQVILRINRAFTDITGYTAGEVLGQTPSLWKTARQESSYYDAMWAGIRFTGMWQGELWNRRKNGEEYPAWFSISAV
REAAGVTTHYVAIFSDITQRKASEESLMQLAFYDPLTKLPNRKLLADRLHQALASSARHQHQCALLQVDVDDFRTFNDALGHEKGDQLLQQVAKRLTACV
REGDTVARLGGDEFLVLMEDLSAPQDKMVGVKVLAALCQPYTIDEVEHRRSCSIGITLLDGAKDGIEEPLKWAELAMYQAKEAGRNTLRFFDPQMQAIVN
VRASIEHNLHRALQENEFRLYYQPQVD-ESGRILGFEALIRWLDPQRGMVPPGEFIPMAEESHLIVSIGRWVLEEACRQLASWADDPATHLTIAVNVSAR
QFHQDEFVEQVLHTLHHSGARANHLKLELTESLLISTVETVIGKMNALKSIGLRFSLDDFGTGYSSLAYLKRLPLDQLKIDQSFVRNILVEPNDAAIARM
VIALAQSMGLSVIAEGVETVAQRDFLYDMGCHNYQGYLYGRPMPIADLTRLLHPVM----
>tr|W0SIU6|W0SIU6_9RHOO PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_03094 PE=4 SV=1
----------------------------------------------------------ARMETRQQA----LL-GQSESEEVFRHLFEDMNDPILLIR-D
GAFVDCNAATLKLLGYSKQQFLDRR---PAEISPPDGR------------SSAAAMITTALQMGYHRFEWMEVTLTPITM--SGAVVLHTLWRDISERLA
AERRLRLLANVFERSGEAIMITDRDNRILEVNQAFVRLTGYGADEVRGHNPSILSSGRTTREEFKAMWQAIENDSFWQGEVWDKRKDGSFYPKWLTISAV
RNGRGEIDYYIGSFADMTERKAAQERINHLALHDTLTGLPNRYNLQGRLDQALATARRDAGRVALLFIDMDRFKNINDTLGHHLGDGLLQEVAVRLTASV
RDSDVVARLGGDEFVVVLTGVEAA--GTVADKILKALGSTYRIDAHELHTTPSIGIAIFPDDGDTAEALMQNADTAMYHAKSAGRNNVQFFTASMNQAAK
DRHELEGGLHLALEREELELHYQPQVD-GLGRVIGAEALLRWQSPDHGLVSPPSFIPLAEETGLILPIGSWVLATACAQLKAWSGDARLSLQLAVNVSPR
EFRQSDFAEQVRRIIESSGANPARLKLELTESLVLDNVEDTILKMQTIKKLGIAFSLDDFGTGYSSLSYLTRLPLDQLKIDRSFVLKLPDNVSDGIVTQT
IITMAAGLGLNAIAEGVETEVQREFLERHGCHAYQGYLFSRPLPLEEFEGFVFAH-----
>tr|B8GT56|B8GT56_THISH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) GN=Tgr7_1990 P
--------------------------------------------------------------------------------------------------QT
GTLHWSPQLYC-IFGVSPESFTPSY-DGYLDLVHPEDRPALLATVEAARSSGEPYTLDHRIVRPDGSIRVIQSQGEALRDADGRIIKLRGTGLDVTERKQ
AEEAKERALVTLHSIGDAVITTDAQGIVTYLNPVAEGLTGWRSSEATGQPLTKVFRIFNEP--TQDPVKTCLEEGRIVNHTVLMSRDGATRAIEDSAAPI
RDRNGLILGVVLVFHDVSKTRQMARQLSWQATHDALTGLFNRYEFEQRLAQALAQARDRLAHHAVLYMDLDQFKVVNDTCGHSAGDELLKQLAYLLMGKV
RESDTLARLGGDEFGVLLENCPLDKAREIAQELRQTVRDFRSWKGKSFQIGISIGLVMISDGNLDLAEVLSAADMACYAAKDLGRDRIHVYHAEDADLQR
RHVEMQARITDALTHDRFVLYTQRIVATGADGGEHMEILLRMVDEKGDLVPPGAFIPAAERYDLMPAIDRWVIRRFFSTMAQHIREEASGCLYAINISGA
SINDETFLGFVTEQLETHRIPPTAICFEITETAAIANLTRAMNLINELRKRGCRFSLDDFGTGVSSFGYLKNLPVDYLKIDGSLVKDIVSDPIDRAMVDA
INRIGQVMGIHTVAEFVENDEILASLRELGVDYAQGYGIDRPKPLLREG-----------
>tr|W8KUU0|W8KUU0_HALHR Diguanylate cyclase OS=Halorhodospira halochloris str. A GN=M911_09500 PE=4 SV=1
--------------------------------------------------------------------------------------------------PE
RAFYWSDEMSR-VLGTAPTERHLNY-ESFIARIHPDDQEAARQSDRKAMEEGIAGELDYRIIGADGNVRHVHEQTQVIRRPDGQVGTVIGTVQDITERKR
AENAKERAQVTLDSIGDAVVTTDADGRVDYLNPAAEALTGWPILEARGKRPDEMFQLVNET--VRTPLDACLREGRNVNHIVMITRDGRTRAIEDSAAPI
RDRQGNTIGAVLVFHDVTKPRQMARKLSWQATHDPLTGLFNRFEFERRLQVALKQAHELQAHHALLYMDLDQFKVVNDTCGHVAGDELLKQLAFTLLAKI
RDSDTLARLGGDEFGVLLEHCPREKALEIANNLRQTVRQFRVWQGRVFEVGISIGAVMLESTAEDMTAVLSAADMACFAAKERGRDRIHVYHPDDQELIQ
RHGEMEARINQALAEHRFRLDVQPIVPVTDQHPPHQEILLRMLDEEGRVVMPGAFIPAAERFGLMPAVDRWVVHHFFSQFAHVLREDSSGTIYAINLSGA
SLNDEQLPGFVIQQLERYQIPASRICFEITETAAIANLTRAGLFMNELRQRGCRFALDDFGTGLSSFTYLKQLPVDYLKIDGSLVRDIARDPIDRSMVDA
IARIGRVMGLHTIAEFVEDDAVLATLAELGVDFAQGYGIARPAPLSQAT-----------
>tr|D9SI90|D9SI90_GALCS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Gallionella capsiferriformans (strain ES-2) GN=Galf_0102 PE=4 S
---------------------------------------------------------------------------------------------------S
GRLNWSEEIFR-LFEIDPAQFSPS---AFLSIIHPEDREAVNQAY-------QSYHITHRLIMAD---KWVEARGSNYFDPEGRAIRSAGTVQDVTFREE
AATQLRIAAVAFD-TQEAIMVTDKEANIIKVNHSFELTTGFSEQEVLGKNPRLLGSGRHNQDFYKSMWEVLNRVGSWSGELWDRRKNGEIYPKWLTITAV
KNR-DEISHYVGVFVDITERKKAEEEIHNLAFFDPLTQLPNRRLLLDRMRLALGLSARSKNFGALMFIDLDHFKVLNDTKGHEYGDKMLIEVSHRLTQSL
RDTDSVARFGGDEFVVLLESLSVNQAGSIAEKMRESLSQTYIIESYAHESTPSIGVVLFNGDAIEIDELLKRADLAMYQAKESGRNTVRFFESAMQATLE
SRTLMERALRQALSNSEFELYYQVQTNQ-ANELLGAEVLLRWHSQSLGPISPAQFIPLAEQTKLILPIGEWVLENACARLKAWETHPLSKLRLAVNISPV
QFHQPDFVRQVQAALTDSGVNPRRLELELTENLVLEDVDEAIQKMSALKALGVRFSMDDFGTGYSSLQYIKRLPIDQLKIDQSFVRDILTDPGDAMMVQT
IAGMARNFGYEVIAEGVEEHAQLLPLIERGCNTFQGYFFSRPVALAEFE-----------
>tr|G0A168|G0A168_METMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylomonas methanica (strain MC09) GN=Metme_4135 PE=4
---------------------------------------------------------------------------------------------------R
LRLVFVGMLDA-SGRIDVLTHSDS---GYVDKLHPYGQAVLARAIRQKQPCIPDTQIWHQLAREA---LAVYSEQADFFTDNIITL-LNGLVNDERQRKQ
AEIELTLAASVFENSQEGIMITDADKTIRRVNLMFSVLTGYAAEECIGKTPQQIACWPQQTALDLAVWDNADARQCWQGEVDSCRRDGEHYPQWLSITKV
VDESGHLTHYVVTFTDITERKLNEARIYKLAFYDPLTDLPNRRLLLEKLEAALIANQRKGGYGAVMFLDLDRFKILNDTQGHNFGDQLLIEAGKRLCRSV
REVDMVARHGGDEFVILLEELSTDQAQKIGNKILNEMNQVYRLHQVEHYSSASIGVAMFHGSGLDSEDLLKQADMAMYQAKQAGRNTLCLFDPQMQAGLN
KRAALEADLRMGLEQNQFKLFYQLQLDR-QRRVVGAEAVLRWEHPLRGLVAPGEFIGLAEESGLIVALGNRALLDACGTLANWALIPMAELNLAVNISAK
QLSQQNFVEQLQALLSQTGADPRRLKLEISENLLLGSVENTVAVMQAATELGVGFSMDDFGTGYSSLTHLQRLPLTQLKIDRAFVSGLSNESDHAAIVRT
ILALGQSLNVQVVAEGVETERQLAYLMSCGCQYFQGYLFGCPEPLADFN-----------
>tr|G3IU84|G3IU84_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_1506 PE=4 SV=
---------------------------------------------------------------------------------------------------A
FKLVWVGMLEP-DGWVRTVAASHP---PLLLNIKPEGRGPMGTAIREGVPKIPSTKPWQPMAAAE---IAVYSAEQDYFTPDLIDL-MRGLTEDEKLRLK
AEHELRIAAAAFE-SQEGILVTDADNNILRVNKSFTQLTGYSADEVIGKSAGILKSGRQAPEFYAAMWESINRDKYWQGEIWNKRKNGNIYPEWLCITAI
TNPEGAVTNYVGTFTDISQRKADEERIKDLAYYDSLTKLPNRTLLFDRLNLALNASNRNKTHGALMFLDLDNFKTLNDTLGHDRGDQLLIEVGRRLQSCV
REVDTVARLGGDEFVVMLECLDEQEAHTVAEKIRSNLAEFYLLKSNEHYSTGSIGFVLFLGHETSSEELLKRADLAMYQAKQAGRNVIRAFIPEMQEALN
LRASLETDLRNALDRGELSLHYQVQVDA-SGRPVGAEALIRWNQAERGMISPAEFIPLAEETGLILSIGYWILKQGCETLVDWAKHPTRELKLAVNISSR
QLSQADFVERVCAMLAETGANPALLKLEITESVILDNVDDTIAKMHAVRDLGVNFSMDDFGTGYSSLSYLQKLPLEQLKIDQSFVRNMAFNNHDSAIIRT
ILALGKNLDINVIAEGVETTIQRELLTRYGCQKFQGYLFGRPVPADAFK-----------
>tr|S6BUZ3|S6BUZ3_9GAMM Signal transduction protein OS=endosymbiont of unidentified scaly snail isolate Monju GN=EBS_0037 PE=4 SV=1
---------------------------------------------------------------------------------------------------E
GRLIWTNPSALRVTGYTPEELLDFP-RP------S-D----DAACDKATWQRGDVECPLLRRDGN------------------HLLGKRASFIDVSERRR
AQRQQARFRALLSAMNLGILFETPEKRVEYVNPAFIDMWALDPEVLVGRPVNEVLELSRY-K-FAHPMRGLHVENTHEEQFEIHLGDGRI--LTQVSYPV
HDNEGRTIGRLWLYEDVTNERQTAEQLIYLAERDSLTGLYNRHRFQIEMERMIGMSQRFGHRFALLYFDLDEFKYINDTFGHREGDTVLTRIAGELAQVV
RKNDVLARLGGDEFAIITLVNKDLD-KQLAHRIVNAVARIPRFHSQNIRITTSIGISVYPDLARDIETLVAQADAAMYQAKAQGKNTWSMYDRSRDATST
MMAHMTWRIEYGLESNLFELHFQGVYRVPSRELAHLEALVRLRDSDDNLYMPGQFIPIAEKNGKILAIDQWVVRQVIRLLAKHPAMP----PVAVNISGR
SFDDPSLPQRIRRWLNDAGVAPERLLVELTETAAVSDIQDAQRFIEGLHQAGCRVCLDDFGAGFSSFAYLKHITADILKIDGQFIHDLPNNPENQIFLRA
MLDVATGLHKTTIAEFVDSPAVFEMLAQFGIDLAQGYYLDKPRPDHPAI-----------
>tr|A0A063Y706|A0A063Y706_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Nitrincola lacisaponensis GN=ADINL_1118 P
---------------------------------------------------------------------------------------------------Q
GHYTLGNRHFYNYFGSDPLGKQLLP---YAAE--YYDDEVVR----TRRPQQ--FEISFPISGVM-------------------PEAICSVATNVTEQER
NAYMLNVSKRIFEHAAEGIMITDAQNRVVDVNPSFERISGFQRKAVLGRDPAFLKSDLHDSDFYQSLWQQVTTEGSWKGELWNKRPDGTAYPVRLSISGI
RDRHGMISGYFGIFEDVSEEYQARTRLRKLAYRDSLTGLFNRLAFKEKVHEFLARARRYHENFALLFVDLDLFKDVNDSFGHEAGDLLLKQVADRILSQV
RDSDIVSRLGGDEFTLLISPVENDILASIAENLIDVLSQPFQLNDVEVTIGCSVGVVSYPRDGENLDQLMRHADAAMYHAKAMGRGCYAFFDVELDQRNH
RLMQIKHGLRQALARDEMHLVYQPEINLQTGQVFGFEVLMRWHSDELGWVSPAEFIPVAEESDSIADLTRWMLIKACRELLP----RETGMQMAVNISPR
QFGGDRWLALIRQCIDEEGLDPTRLCIEITEGALIRDMDQAVVQLSELRKLGVSVAIDDFGTGYSSLSYLKRLPIDYLKIDRTFVADIEQDQDDQAIIRA
IINLADSLGISVIAEGVESEAQLDFLKSLDCDIAQGYFFAHPQAIDKIK-----------
>tr|A0A081G1R6|A0A081G1R6_9ALTE Diguanylate cyclase OS=Marinobacterium sp. AK27 GN=ADIMK_1174 PE=4 SV=1
---------------------------------------------------------------------------------------------------E
GRFVYVNTRFVGTYGFNPVEDQKTP-QELLAR--RVNRQVLD----SGESAQ--FEWTTQLGGRS-------------------QARVCTISLDITEKEQ
NEQLVNLSRRIFENTTEGIIVTDADRKIVELNDSFARIAGYQKHELVGRRPDMLKSGRQDDVFYREFWKELRGQGRWRGEVVNRRPDGTLYPARLSVSSI
VDRNGRISGYFAIYQDISAEKRAEQALRELAYYDTLTGLYNRASFKQKVAEALQQLDRFQEPFGLLFIDLDRFKEVNDSSGHELGDKLLVQVACRLESQL
RKVDVACRLGGDEFTVLVSHASDDSLATIAEKLIEALAKPYRVEGQELVIGCSIGIVVAPRDGEDRDQLMRNADAAMYYAKESGRGRYAFFDTRIDERNR
RLVRIKQGLRQAEANGELSLVYQPEVDPNTGEVRMYEALMRWNSAELGSVSPAEFIAVAEETDMIVDLTRWLIGEVARDSHQ----ELKHSKISINLSPR
QFRSDSWQDRVRDAIQDGALDPTRLCIEVTESALVEDFALANEQLREIKQLGIEVAIDDFGTGYSSLAYLKRLPIDYLKIDRSFVADIHLDPDDRTIVET
VIVMAHALGLKVVAEGAETEQQVAFLREQGCDLIQGYFYARPLTLAALV-----------
>tr|W7S973|W7S973_9PSEU Sensory box/GGDEF domain/EAL domain protein OS=Kutzneria sp. 744 GN=KUTG_00976 PE=4 SV=1
--------------------------------------------------------------------------------------------------DL
GQLVWELFLLPEDQP-----------------------------CIKGQFDDHNFECPWLTRSGE------------VDESGAVTH-VIATGIDVTAQRA
AEEAKERFQKAFDYASIGMCLVDLDGRFTQVNRALCEMLARPEGELLALRVADVTHP---DDVSASLATVEVAKDGYTLEKRYLRSDGR--TVWAQVTVC
TIENGASPYFVTQVEDVTERREAEARLVRQALHDPLTGLPNRTLLMDRLRQVLARADRHPELTAVLFIDLDGFKDVNDSLGHDVGDEVLTEVGRRLQEHI
RPLDTVARLGGDEFVVLCQDLASEQVE-ISERLAGVLSEPVVVDSYEVVVTASVGIALANGHNPAPEDLLREADAAMYGAKTRGKNRCEIFDAGLQERAV
DRIAIASALRQGLRDDRFVLHFQPVVDMVTGDTVAVESLVRLDDPDRGLLAPDTFIQVAEDSGLIVPIGTSVLEQACRKLMSWRSSGPAGLRTAVNLSAR
QATRPDLAATIEHALAESGLEPSGLTLELTETVLMEADAATLRQLERIRELGVGLGIDDFGTGYSSLTYLKRLPVSFVKIDRSFVAGLVTDPSDREIVTA
VIRLGQALGLTTIAEGVEEPAQFEMLRALGCDQAQGYLLGRPKPGPPGE-----------
>tr|A2SJ79|A2SJ79_METPP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylibium petroleiphilum (strain PM1) GN=Mpe_A2664 PE=4 SV=1
--------------------------------------------------------------------------------------------------P-
-ADPWKHGLDSS--------------------------------VRARFFQQDEFEVRWGAGTEP-----------------------------------
-ERRLELWAKVFEASSEGILIVDAQRRILTANQAFSRHTGYELQEVVGEKPSLMLAVEQTDEQSAAFWQSVSNRGTWQGELQVRRRNGSEYPAWLMVNAV
RQSQGDISHYIFTSIDISDRKKSEQRIRFLADHDVLTELPNRSLCTERLRMAVQQAQRSGQQVAVMFIDLDRFKDINDSLGHHIGDGLLRSVARRLLEAV
RAGDTVSRLGGDEFVIVLNGVQHIDTHIVDQRLIPLIRQPHLVEGAELHVSCSVGIAVFPDDATDIDELMKHADTAMYQAKAGGKDAAEFFTAEMTQRAE
SRMQLDADLRRALELGQFELHWQPRVSAAGGVLLGVEGLLRWQHPQRGLVSPAHFIPLAEETGLIVPIGAWVIEEACRQVAAWRAQGLPSFGVSINLSAR
QLRDDGLTDLVRASLLRHGVPPGVLELELTESMVMDDAERNLRQMHTLRDLGVGLAIDDFGTGYSSLAYLNRFPIDKLKIDRSFVHDMLADPTDRAITMA
IIGLGHALGLQVVAEGVEEPRAAALLREARCDELQGYLFGRPMPVPAFE-----------
>tr|B1XZW3|B1XZW3_LEPCP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) GN=L
--------------------------------------------------------------------------------------------------P-
-ADPWALGLDSH--------------------------------VRARFFQQDEFEVHWRGPTEA-----------------------------------
-EQRLELWAKVFETSSEGIFIVDAQQRILTANWALTRSTGHDLIELMGGDPAELLAGADARQTWQSLVERVQTRGSWQGEVRICRRAGGDYPAWLLANAV
RDRAGHVSHWVCTSIDITDRKESERRIRFLAEHDVLTELPNRALCIERLRLALQQARRTGQKVAVLFIDLDRFKNINDSLGHHVGDGLLRSVAQRLVDGV
RAGDTVSRLGGDEFVVVLNGLADIEAHVVEQRLIPRVRQPHGVQGAEIHVSCSVGISVFPDDAQDIDELMRQADVAMYQAKAQGRNGAQFFTAEMNQRAQ
ARLMVENHLRSAVAQGQLSLHYQPRIHVADGRVAGVEGLLRWHSPELGHVPPDRFIPVAEETGLIIEIGAWVIEAACAQIERWRGQGLQEVAVSINLSAL
QLRDPGLLDVLRASLERHAVPPGQLELELTESILMDQVDAHLVTLHALRELGLRLSIDDFGTGYSSLNYLTRFPIDQLKIDRSFVRDMLDDPRDLAIIKA
IIGLGHTLGLKVVAEGVERELEVQALRAAGCDELQGYHFARPMAADTAT-----------
>tr|W6WBN6|W6WBN6_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC and integral membrane sensor(S) OS=Burkholderia sp. BT03 GN=PMI06_000996 PE=
--------------------------------------------------------------------------------------------------P-
-TDPWAYGLDSS--------------------------------VRARFFQQDEFEVRWKASTEP-----------------------------------
-EQRLELWAKVFEASSEAILILDQERRLLTANASFYRATGYRAEDIAGQPPAFIVAGANGGAVITALATLVDRSSSWNGEAQIRRRQGGDYPAWLMISAV
RDKRGSVSHYICTLIDITDRKKSEARIEFLAEHDVLTELPNRALFTKRLGVALEHAKQAQQRVAVLFIDLDRFKDINDSLGHHIGDGLLRSVSRRLVQAV
RSSDTVSRLGGDEFTMILADAGSAAARTIDERLLPLVREPHAIGGVTLQVACSAGVALYPDDGTDIETLMQNADAAMYQAKAAGRNLVKFFSPDMAERAR
QRLALEACMRTAIERHELRLAFQPCLDAQTGALVSVEGLLRWTHPQLGAVTPAQFIPIAEETRLIIPIGAWVIDEACRQLARWRDDEMGELRMSINLSAI
QLRDADIVDTLRRSLAMHGVAPQRLELEITETVLMDSAENYLEAIRAIRALGVKLSLDDFGTGYSSLSYLNRFPLDRLKIDRAFVRDMLDAPADLAVIKA
IIELGHELGLRVVAEGVENEDEANTLRSIGCDELQGFLYSPAISAEELE-----------
>tr|A0A095WAA0|A0A095WAA0_BURGA Diguanylate phosphodiesterase OS=Burkholderia gladioli GN=LA03_11135 PE=4 SV=1
--------------------------------------------------------------------------------------------------P-
-SDPWALGLDSA--------------------------------VRARFFQQDQFEVRWRASEEP-----------------------------------
-EQRLELWAKVFEASSEAILILDSERRLLTANASFYRATGYRAEKISGTLPNFVLASGSDQPLMSRLAALVDISSVWNGEAVVRRRAGGDYPAWLMISAV
RDKHGAVSHYICTLIDITDRKKSEARIRFLAEHDVLTELPNRALFTRRLGTAIEQARHNHSRVAVLFIDLDRFKDINDTFGHHAGDGLLRSVSQRLLQSV
RAGDTVSRLGGDEFTVLLGGAGSAAAHLLDERLLPLMQEPHQIGGMTLQVACSIGIALYPDHGEDIETLMQNADAAMYRAKSGGRNLVKFFSPEMAESVR
HRLELETHLRTSVERRELWLEYQPCVQAATDQLLSVEALLRWKHPHLGMVPPSQFIPIAEETRLIVPIGAWVIDEACRQIARWRAAGLPEIRVSINLSVV
QLRDAQLVDKLRDGLTAHDVKPDSLELEITETVLMESVDHYLDTVNEIRALGVKLSLDDFGTGYSSLSYLHRFPLDRLKIDRAFVNGRLDALADLAVIRA
IVELGHELGLRVVAEGVEQAHEANALKRIGCDELQGFYYARPMSNEALE-----------
>tr|Q13LQ1|Q13LQ1_BURXL Putative diguanylate cyclase/phosphodiesterase(GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Burkholderia xenovorans (strain L
--------------------------------------------------------------------------------------------------P-
-VDPWAVGLDSE--------------------------------VRARFFQQDEFEVHWKAAKES-----------------------------------
-EQRLELWGKVFEASSEAILILDAQRRLVTANASFYRATGYRADNVTGKEPAFLFGTQDHDDILPAVIDSVDRLSVWHGEAHVRRRAGSDYPAWLMVSAV
RDRRANLSHYICTLIDITDRKKSEARIQFLAEHDVLTELPNRELFVKRLGVVLGNARRTGQRVAVLFIDLDRFKNINDSLGHHIGDSLLRSVSRRLLQAV
RTNDTVSRLGGDEFTVILNSVSNAATRTIEERLLPLVRQPHEVGGVTLQVSCSVGVALFPDDGEDIETLMQNADAAMYQAKGAGRNLVKFFAPDIAERTR
YRLTLEACLRSAIAMHEFRLEYQPCVDAHTGELVAVEGLLRWNSPQIGIVSPAQFIPVAEDTRLIIPIGAWVINEACQQIAAWDAEGLTPLRVSINLSAI
QLRDPDLIGTLADSLARHGVAPWRLELEITETVLMDNAENYLTMINAIRALGVKLSLDDFGIGYSSLSYLNRFPLDRLKIDRAFVLDMLDARADLAIVRA
IIELGHELGLRVVAEGVESEHQARILRTIGCDELQGFLFSKALSPADLW-----------
>tr|A0A090HIW0|A0A090HIW0_9BURK Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Burkholderia glathei GN=BGLT_02429 PE=4 S
--------------------------------------------------------------------------------------------------P-
-TDPWAFSLDSS--------------------------------TRARFFQQDEFEVHWKGTSQP-----------------------------------
-EQRLELWGKVFEASSEAIVILDGQARLVTANPSFYRATGYRIDDVAGKPPSFIFGGTGDGGAIPGL-ASIDRKSTWHGEAQVRRREGGDYPAWLMISAV
RDKRGNISHYICTLIDITDRKKSEARIQFLAEHDVLTELPNRALFASRLGDAISQAGRARRRVAVLFIDLDRFKNINDSLGHHIGDGLLRSVSRRLLKAV
RSNDTVSRLGGDEFTVILNGVTHAATRTIDQRLIPLLREPHAVGGVTLQVSCSVGVALYPDDGSDIDTLMQNADAAMYQAKAAGRNLVKFFSADMAEHAR
YRLTLEACLRTAIERNEMRLAYQPCLDARTGALASVEGLLRWESPQLGAVPPAEFIPVAEETRLIVQIGAWVIDEACRQIAQWRESDALDIRVSVNLSAI
QLRDPDLVGVLSHSLAKHRVPPESLELEITETVLMDSAENYVDAIRAIRGLGVRLSLDDFGTGYSSLSYLNRFPLDRLKIDRAFVHDMLEAPADLAIVKA
IIELGHELGLRVVAEGVESEHQAHILRGIGCDELQGFLFSTALSSKELW-----------
>tr|B2TG91|B2TG91_BURPP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia phytofirmans (strain DSM 17436 / PsJN) GN=Bphyt_56
--------------------------------------------------------------------------------------------------P-
-VDPWGYGLDSE--------------------------------VRARFFQQDEFEVRWKASNEP-----------------------------------
-EQRLELWGKVFEASSEAILILDAQRRLVTANASFYRATGYRADDVAGKEPAFLSGAHVQGDLLAAVIDSVDRQSAWHGEANVRRRAGSDYPAWLMISAV
RDRRASLSHYICTLIDITDRKKSEARIQFLAEHDLLTELPNRALFMKRLRAVLDHARVADHRVAVLFIDLDRFKHVNDSLGHHIGDSLLRSVSRRLVRAV
RADDTVSRLSGDEFTIILNGVSGAAGRTIEDRLLPLMRQPHELDGMALPVSCSVGVALFPDDGEDIETLMQNADAAMYQAKGAGRNLVKFFTPDMAERAL
HRAQLEASLRNAIAMDEFRLEYQPCIDARTGELVAVEGLLRWHNPRLGKVSPAEFIPIAEESRLIISMGAWVIEQACRQIAEWNDEGLAPLRVSINVSAI
QLRDPNLIGMLATSLERNRVAPERLELEITETVLMDSAEHYESTVAGIRKLGIKLSLDDFGVGYSSLSYLNRFPLDRLKIDRAFVKDMLDAPADLAIIRA
IIELGHELGLRVVAEGVESEHQAQILRNIGCDELQGFLFSPSLSPADLG-----------
>tr|A0A069P3B1|A0A069P3B1_9BURK Diguanylate phosphodiesterase OS=Burkholderia grimmiae GN=BG57_32580 PE=4 SV=1
--------------------------------------------------------------------------------------------------P-
-TDPWAQGLDSA--------------------------------TRARFFQQDEFEVHWKATSQP-----------------------------------
-EQRLELWGKVFEASSEAIVILNAEARLLTANPSFFRATGYRIDDVAGKPPAFIDSQAQDNGPLGNLLQRVGRSSTWHGEAQISRREGGDYPAWLMISAV
HDKRGTVSHYICTLIDITDRKKSEARIQFLAQHDVLTELPNRALFAAKLGVAIAAAQRTRQRVAVLFIDLDRFKNINDSLGHHIGDGLLRSVSRRLLNAV
GTDDTVSRLGGDEFTVLLNGVGHASARSIEQRLLPLLREAHEVSGLTLQVASSIGVALYPDDGEDIDTLMQNADAAMYQAKSAGRNQVKFFSADMAEQAR
HRLTLETCLRTAIEFSELRLEWQPCLEARSGALASVEGLLRWKSAVLGEIGPAVFIPVAEDTRLIVSIGAWVIEEACRQLAAWRDEAGLEIRASVNISAI
QLREPELVAALAKSLLAHGVPPHCLELEITETVLMDGAEHYAQAIHAIRGLGVKLSLDDFGTGYSSLSYLNRIPLDRLKIDRAFVRDMLDASADLAIVKA
IVDLGHELGLRVVAEGVETGHQAQVLRKIGCDELQGFLFAPAIPAEELV-----------
>tr|F0Q6L9|F0Q6L9_ACIAP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM 20985 / N
--------------------------------------------------------------------------------------------------P-
-HDPWRAGLEPG--------------------------------VRARFFQRDEFEVRWKGGKEP-----------------------------------
-EQRLELWAKVFEASSEGIIIMNAAQRIVSVNQAFCRSTHYDFYEVIGEQLGMLLDAP-GSAPGETIARALADKESWQGEVRFRRRSGESYPAWLMVSAV
REKGGAVTNHIGIAIDITDRKRNEERIRFLAHHDVLTELPNRSLCVQRLQAGLEQAARTGEQLAVLFIDLDRFKAINDTLGHHIGDGLLRSVAARLVQSV
REGDTVSRLGGDEFVIVMRQVEGAQLRVVEERLIPLIRQSHPVEAHELSVSCSVGIAVYPEDGADLDELMRRADAAMYEAKTAGRDMARLYSLETDRRVQ
ARQAMEQSLRRALERREFALHYQPRMSARTGMPTGLEALLRWRHPSLGEVLPGEFIPIAEEAGLIRAIGAWVLDQACAQWAAWRASE--GLPVSVNLSAA
QLADPLLVPDIAALLARHGMPARCLELEITESQLMDNAGVAQGQLAALKQLGVQLSIDDFGTGYSSLAYLKRFAIDKLKVDKSFIRDMLASPADMAITRA
IIGLGRTLGLQVVAEGVEDAATLRMLESLDCDEVQGYLFSRALPPEALQ-----------
>tr|K0I7L0|K0I7L0_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. KKS102 GN=C380_17550 PE=4 SV=1
--------------------------------------------------------------------------------------------------P-
-TDPWAVGLEPG--------------------------------VRARFFQRDEFEVRWKGSPEP-----------------------------------
-EQRLELWAKVFEASSEGIIIMNAEQQIISVNKAFCRSTHYDFYEVIGEDLGFLLEES-GEPLSAQIQRTMLDKESWQGEVRFRRRSGETYPAWLMVSAV
REKGGAVANHIGIAIDITDRKLNEERIQFLAHHDVLTELPNRSLCVQRLQMALAQAPITGEKVAVLFIDLDRFKAINDTLGHHIGDGLLRSVAARLTQAV
RSRDTVSRLGGDEFVVVMRDVAGREQQLVERRLIPLIRQSHPVEGHELNVSCSVGIAVYPEDGSDIDELMRRADAAMYEAKTTGRDMALFYSMETDQRAV
ARQTMEQQLRRALERHELSLHYQPRLSAQGAQLLGVEALLRWTSPVLGSIPPSEFIPIAEETGMIRAIGSWVLQQACEQWVRWQQLVLARVSISVNLSAA
QMSDPALVADIEALLLRTGMPAHRLELEITESQLMDNAHAAEQQLAALKALGVQLSIDDFGTGYSSLAYLKRFDIDRLKVDKSFVRDMLANPADMAITRA
IIALGHTLGLRIVAEGVEDLATAQVLSALDCEELQGYHFSRPLPVPELE-----------
>tr|H0C3Z4|H0C3Z4_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax sp. NO-1 GN=KYG_22076 PE=4 SV=1
--------------------------------------------------------------------------------------------------P-
-TDPWAAGLEPG--------------------------------VRARFFQRDEFEVRWKGGAEA-----------------------------------
-EQRLELWAKVFEASSEGIIIMNADQKIISVNKAFCRSTHYDFYEVIGEDLGFLLEDA-GEPLSQQISRTMQEKESWQGEVRFRRRSGETYPAWLMVSAV
REKGGPVANHIGISIDITDRKLNEERIQFLAHHDVLTELPNRSLCVQRLQAALAQAPITGEKVAVLFIDLDRFKSINDTLGHHIGDGLLRSVAGRLTQAV
RSRDTVSRLGGDEFVVIMRDVAGREQQLVERRLISLIRQSHPVEGHELNVSCSVGIAVYPEDGSDIDELMRRADAAMYEAKTTGRDMACFYSAETDQRAL
ARQTVEQHLRRALDRNEFSLHYQPRLAASGGQLLGVEALLRWTNPALGQIPPGEFIPIAEETGMIRAIGHWVLQQACAQWVQWQAPA--DVCVSVNLSAA
QLADPQLVPDIAALLARTGMPAHRLELEITESQLMDNAHAAEQQLAALKALGVLLSIDDFGTGYSSLAYLKRFDIDRLKVDKSFVHDMLTNPADLAITRA
IIALGHTLGLKIVAEGVEDLATAQVLSALGCEELQGYHFSRPLPPQALL-----------
>tr|J1ED54|J1ED54_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_05126 PE=4 SV=1
--------------------------------------------------------------------------------------------------P-
-IDPWVAGLEPG--------------------------------VRGRFFQRDEFEVRWKGGPEP-----------------------------------
-EQRLELWAKVFEASSEGIIIMNADQQIISVNKAFCRSTHYDFYEVIGEGLGFLQEDSEGEPLSAQIARAMQDKESWQGEVRFRRRSGETYPAWLMVSAV
REKAGAVVNHIGIAIDITDRKQNEERIQFLAHHDVLTELPNRSLCVQRLQLALAHANAFGERVAVLFIDLDRFKAINDTLGHHIGDGLLRSVAQRLTQAV
RSRDTVSRLGGDEFVVIMRDVAGPEQQLVENRLIPLIRQPHPVEGHELNVSCSVGIAVYPEDGGDIDELMRRADAAMYEAKTTGRDMALFYSAETDQRAL
ARQSMEQHLRRALGRGELSLHYQPRLSARGSRVLGVEALLRWNNPVLGMVPPSEFIPIAEETGMIRAIGAWVLQQACSQWVAWQSLELAQVSVSVNLSAA
QLADPQLVPDIEALLTRCGMPAHRLELEITESQLMDHANSAERQLAALKALGVQLSIDDFGTGYSSLAYLKRFDIDRLKVDKSFIHDMLTNPADMAITRA
IIALGHTLGLKIVAEGVEDLATVQVLDALDCEELQGFHFTRPLPVAQLQ-----------
>tr|A0A0A6DQP8|A0A0A6DQP8_9BURK Diguanylate phosphodiesterase OS=Janthinobacterium lividum GN=NC77_13500 PE=4 SV=1
--------------------------------------------------------------------------------------------------A-
-LDPWVGGMSPQ--------------------------------ARSRFFQRDEFEVCWSGSGTP-----------------------------------
-ESRLELWAKVFEASAESLIVMDAGMRIITVNQAFRRHSLYDMVELIGKRPAFLLAPDNSPEQLDSLRRTLARRGYWQGEIRVQRKSLESYPAWLVMNAV
RDLDGVTTHFIASSLDISERKASERQIEHMAHHDALTGLANRHVSKLRLAAAIAQARRSGEKVGVLFVDLDRFKHVNDALGHHVGDALLQSVSARLLQLV
REGDTVSRLGGDEFVVILNGIGDAAAALLDTRLIPAMRQPHQVEGNELYVSCSVGVAIYPDHGGDMDTLMRHADAAMYQAKSGGRDHARMFTPQMQEQQL
QQLHLESDLRHAIERQELVLYYQPRIDAKSSRLNGVESLIRWQHPQHGLIAPDSFIPAAEESGLIVSIGAWVIREACRQQVAWREAGAGDIAVSINLSAI
QLKSGGLVATLREVLREFPVTPGQIEFELTESILMDNVDDTIATLHAIKALGFALSIDDFGTGYSSLNYLCRFPLDKLKIDMSFVQDIHGSPQNLAVTKT
IIGLGHTLGLTVTAEGVESAADADVLRHAGCDELQGYYFARPMPQAHFM-----------
>tr|C9YDS1|C9YDS1_9BURK Uncharacterized signaling protein CC_0091 OS=Curvibacter putative symbiont of Hydra magnipapillata GN=Csp_F37680 PE=4 SV=1
--------------------------------------------------------------------------------------------------P-
-DDPWRHGLEPG--------------------------------VRGRFFQRDEFEVRWHGGTTP-----------------------------------
-EQRLELWAKVFEASSESIIIMDEARKIISVNQAFCRSTGYDFYEALGQDLSFVMNTPQ-----DTVWADLEDQNDWQGEVHFCKQNGDTYPAWLMVSSV
HKTSGEVVNYIGISIDITDRKAKEERIRFLAQHDVLTELPNRALCQQRLGEAIASARHTGEKVAVLFIDLDRFKLINDTLGHHIGDGLLRTVARRLSSAV
RSDDTVSRLGGDEFVIILRHVTDLPTAMVNDRLIPTIRQTATVDGHVLTVSCSVGVALYPEDATDQDELMRRADAAMYEAKSAGRDTARFFSPETDQRVL
ARQSMETQLRQALANEEFSLHYQPRLNARTRKVQGAEALLRWKNPLLGQVPPGEFIHVAEESGLIKPIGAWVLREACRNWMSMEEQG-KGLELSVNLSVA
QLADPELVDQLSAVLRDTRMPPAQLELELTESHLMDNPVAAQQQVAALKALGVKVAIDDFGTGYSSLAYLKRFDIDKLKVDQSFVLGMLEDSADAAIVHA
VIALGHTLGLKVVAEGVENLPTAQTLTALGCDELQGYCFSRPIPLAEWV-----------
>tr|A1ALY4|A1ALY4_PELPD Diguanylate cyclase/phosphodiesterase OS=Pelobacter propionicus (strain DSM 2379) GN=Ppro_0723 PE=4 SV=1
--------------------------------------------------------------------------------------------------PE
SWSPFDVIAGEN--------------------------------QRETFLSLDEYELLLRLPGAPSSSREIYLLTSRLFLLGGEDC-LITVGIDISARRR
AEATLELWGRVFECTSESIMITDAAQRIVSVNQAFCATTGYRAEEIIGQSSLALRSDVHDGIYFRQLWRGIRKRGSWQGEFWCRHKNGEVSPQWMVVNTV
HDRQGTVTNYIALFTDISAQKSQEQRIQHIAHHDALTNLPNRLLCMERLILALQQAHRNGRHVAVIFIDLDHFKNINDSLGHHVGDCVLVTAANRLSMGV
RDGDTVSRLGGDEFVIILADIEDSHEEIMKHRLLPLMRQPYDAGGYELHCSCSIGISIFPEDGLDKDTLLRNADTAMYRAKEVGRNNYHFYTEELNSRAM
QRLSIETSLRKGIERNELLLHYQPKLDLHTGKPYGLEALLRWQHPDHGMISPMEFIPIAEETGLIIPIGKQVIRNACRQLSRWSSVGMSHICLSLNVSAV
QFRDRRFVEDLVQLVREEGVSPHRIELELTETMLMEDAVRTIRVMETLKDEGFLFSIDDFGTGYSSLNYLHRFPIDCLKIDRSFIRGMLERPADLAIIKA
IIGLGHTLDMQVIAEGVEKEDEYRALRAAGCDGIQGYFVARPLTPEQVP-----------
>tr|A0A0A8WWH2|A0A0A8WWH2_9DELT DNA, contig: OR1_contig000023 OS=Geobacter sp. OR-1 GN=OR1_03668 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------RLGAWDYITKPIQDLAELELIVARLIRENREYHENLE
MLVEIRKLFKAVEQSANSVIITDVNGIIEYVNPKFTDTTGYSIDEVVGQRPSVLKSGKQPESFYRELWRSIKSGNRGELCN--RRKNGELFWEMCSIAPI
RDELGNITDYVAIKEDITERKRYEDQLAYQANYDLLTGLPNRYYLQGFLEAHLCRLNQECLYATLMMLDIDNMKFINDTFGHAFGDLLLKEIAERLKTLY
GEGSFVARFVGNQFAIIPDISSLENLAEHAEILRKALNEVYMVKGTEVLATASVGVVAYPEDGETVENLLKNAEVAMYEAKKQGKNTVAFYTSELNVQVE
NRLSMETRLHKALARGEFSIHYQPQICLNTGSIIGMEALLRWQTESDTYISPAQFIPILEETGLVLEVGEWVLNEACRQSVVWEQRGLKDLRVSVNISAL
QFMRSDLDVTVRNVLQTSGLDPKKLCLELTESMIMIDSSRTMEKLESLTKLGITLSLDDFGTGYSSLEYLGRLPIHELKIDQSFVRRMSNTKNDAAVVNT
IIAMGHGLGMDLVAEGVETIEQLAYLNEKKCGYIQGFLFSKPLPVAEFENFCMAWVP---
>tr|M2Z5G5|M2Z5G5_9PROT PAS/PAC sensors-containing diguanylate cyclase/phosphodiesterase OS=Magnetospirillum sp. SO-1 GN=H261_12914 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------QIGATDFLAKPI-DHVEF---ALASCRAHKTLAEVSL
-----------VRQSPASVVITDSDGIIEYVNPKFTETTGYRPEEVIGQRPSLLKSGYSTPEMYRELWDTITGGN-WRGTFQNRRKDGSMLWEQALISPI
RDETGAITNFVAIKEDITLRKEYEARLEWQANYDSLTGLPNRMLVLDRLGQAIALAGRNSDQVAVMLVDLDRFKAVNDTMGHDAGDEILRQVAQRLRIEQ
RQADTVARVGNDEFVMVLTDLGEHAPQAVAARICARLEAPFQVGDAEIFISASIGIALFPENGSTAQDLLRSATAAMPVAETEGRGNWRFFTPELDASAR
KRLAIEASLRHALERGEFQVHYHPLVEVASGHILAAEALLRWTNPDLGPVAPDLFIPIAEETGLIVPIGAWVVETVCRDIARWAGQG-PPIRVAVNVSSR
QLADRALLEVIARALAGQGVAAGLVEIEVTERLLLDQSPHTLTLLNDLKDMGLRFSIDDFGTGYSSMSYLTSFPFDVLKIDRSFISKVTERGQDKALTQA
IIAMAHSLDLEVVAEGVETHAQLEFLRRSGCDFAQGYLFTRPVSAAAFAEVLNGGGK---
>tr|Q315R3|Q315R3_DESAG Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio alaskensis 
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------RHGAWDYVTKPISDMVVLEHAVARLLDERDRYRERLE
QEVELRESNERIESMPNPVFFKSLEGEYLGCNAAFCRILGKPKEDIVGRRAEDLLPEEVACRVLEGGVLSGAQ--RAHSCTIMLGDDGGPLQLVLYKSFF
QNRAGENAGVVGTFHDITELKKKEAQIYHQAYHDELTGLANRVRLKDAIADRIRL-GG-DGGLAVLMLDLDNFKNVNDSLGHGVGDKLLLEASRRLRDVV
GPQPLLARTGGDEFALLLD----CKANRLAAKVLDAFTVPFVIDEHELYITISIGLTCWPEDGADADSLVKNADVAMYKAKEQGRSRCLHFDAEMTEQVT
RRLSIEKSIRKGLERDEFQVYYQPRINIFNGRLVGMEALVRWVPEH-AVVSPAEFIPVAEETGLIVALGERVLRLACAQMRIWADRGWGDLRMSVNISAR
QFQ-ANLTERVAAALRDSGISPDSLELEITETTMMRDIGQTVLLLEQLNGMGLKIAIDDFGTGHSSLYYLKRFPISTLKIDRSFVRDIMKDDGDANIVST
IITMGHNLSLNVVAEGVETDEQLAFLRDKGCVEVQGFYYSRPVPAAEFEDFVLRHRS---
>tr|B8DLW6|B8DLW6_DESVM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio vulgaris (s
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------RHGAWDYVTKPVTDMRVLEHAVARLLEERKRYREHLE
QEVELRETNERVEGMPNPVFYKTLEGNYIGCNRAFSRLIGRAPEDIVGRSVHEILPQEQACRVEDSGRRLTVQDDAGYSCMILRDAAGEDRVLVLYKSYF
RDRTGQRAGEVGTFLDVSELKRKEAQIVHQATHDELTGLPNRMGLRQRMEDHALKGGP-DARLAVLYLDMDNFKTVNDSLGHAVGDELLRAVAGRLVGMA
PRRDMVARLGGDEFVVLLPLSAEDGAETESARIQDSFTRPFNAADHELYVMPSIGISVAPEDGRDPATLLKNAEIAMYRAKEQGGARFRRFTQAMNDDVT
RRLAIEKSIRKGLENDEFVVFYQPRVDIVTGQVTGMEALVRWARPD-TLVPPLEFIPVAEDTGLVVALGERVLRDACIQTRRWTDE-LGPLRIAVNISAR
QFQ-PDLLDRVQAALAESGLPPSQLELEITETTMMRDLPTSVAILERLAAQGISIAIDDFGTGHSSLYYLKNFPIDTIKIDRSFVRDVPGDEGDATIVST
IVTMGRNLSLNVVAEGVETDDQLGFLRAHGCREVQGYYYSKPLPADGFADWMRAALA---
>tr|A0A0E0SZ02|A0A0E0SZ02_DESVR Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio vulgaris (s
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------RRGAWDYVTKPVLDMRVLEHAVARLLDERQRYQERLE
FEVELRVSNEQIESLPNPLFYKTLDGVYIGCNKAFSQLLGIPREKMVGRSARDLLPDHAYAQIIAGDCPSGS---GEHSCVFILGADGHIHTLALYKSTY
SDSQGQVSGIVGTFLDITELKRKEAQIVHQATHDELTGLLNRFGMRQHVDRLI--VGG-QMSFALLVIDLDDFKTINDSLGHALGDRLLHKAAERIVELV
GSQGIVGRPGGDEYVVLLYN---DAAHAMARRILDIFTDSLSVSGHEVYISLSIGIAVYPEDGDDAANLFKCCDIAMYRAKEEGGARAQRYLAAMQDVIT
SRLALEKNLRKALERGEFVLHYQPKVDIRTGAVTGMEALVRWVRDD-TIVPPQDFIPVAEKTGLIVALGEFVLREACRQMHAWQKR-FGRLKMAVNISAR
QFQ-PGLPDTVASALADAGLDPGLLELEITETTMMRDLALTVSVLERLTTGGIAVAIDDFGTGHSSLYYLKTFPISSIKIDRSFVRDIPNDETDATIVTT
VVSMGRNLGIGIVAEGVETEAQLDFLRSLECPEVQGYYFSKPLPPHAFEAWMENRLR---
>tr|B3PKJ2|B3PKJ2_CELJU EAL domain protein OS=Cellvibrio japonicus (strain Ueda107) GN=CJA_2460 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------QMLEFQWSRDPMCVRHWEARIVQEVLLVVREITQRR-
-----------FEASNEAILITDANFRIISVNRAYETIMGYREQDVLGVDTLEVGAKLQTYSFYRNLVSLLKERG-WQGELINQRKSGEEFPSWFSVTQV
TNSRGEPEHYIAIFNDITEHKNSRAQIEFLAHHDALTGLPNRILLNDRLEMAITQVRRQGEKLGILFIDLDRFKNVNDSLGHGVGDQILQEAAKRLTANV
RTGDTVSRLGGDEFVVLFPRVRTGNLADLTIKLREQLQLPYTVDGISLHITPSIGIAVYPDDGEDPNTLIKNADAAMYLAKEKGRNNYQFYTPTLNAKTL
DRLKLESDLRSAIDAGDFELHYQPQIIGSSGQLWGLEALIRWRHRERGLISPAEFIPLAEETGLIVGLGDWVLVQAVKQLAEWRRQG-NHLVVSVNISAL
QFRQGDFLDRVKHILQEAQLVPDAIELELTETMLMQDVQSAIQTLKGLRELGFRIAIDDFGTGFSSLNYLRHLPINVLKIDQSFVREMLQEPESLAIVES
IIALAQALGKETIAEGVETRAEFDVLQARGCRLMQGYFFARPMPPVIFDQWYQQQTQ---
>tr|Q1K1R0|Q1K1R0_DESAC Response regulator receiver modulated diguanylate cyclase/phosphodiesterase OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_1792 
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------RRGATDYLLKSRMPKLGQV--VKRALQERHILHEKQ-
-----------IDGLEMQVMITDRDFNIQVLNWQAQKLVPVG-QSATEMTCYQLTRGFDSPCSEHGMECPALAKN-ATKVQQYQDENGENVSVEKTATLL
RNRQDDVTGIFLTCRDISENMYKEMQLEQILHYDTLTGLPQRDFFFDLLHSHMVGCQKNNRTLALLYLDLDRFKNINDTLGHTVGDQVLQEVAQRLQNNI
RITDNLSRMSGDEFLITLDPADNSEVTQLAQKFLSVISVPMKIEHHRFHLTASIGISLFPGDATSPEKLLSCADSAMYRAKESGRDAFRFYKPHMNEKAQ
GLLWLETELRLAIEQEQLELHYQPQYDLNTGQLVGMEALVRWNHPEKGMIPPGEFIPQAEETSLIIPLGEWVLNTACRQIAAWHAMGISPIRMAVNISAV
QFYRIDLAQMVAKLLDHYGLPATLLELEITESVLMDDVEAAAETMNKLTAMGIQLSIDDFGTGYSSLSYLKRFPISTLKIDRSFINDVTINEQDAAIALS
IISLAGHMGIEVLAEGVETVEQLSFLQRHACQYGQGYLFNRPLPAKDIERQLKTAHL---
>tr|T1ASQ8|T1ASQ8_9ZZZZ Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=mine drainage metagenome GN=B1A_14989 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------KDYVLKDR-LARLAPAVR---LTLLAEQEVHARK-
-----------FE-TQEGIVITDRDQHILRVNCAFTRLTGYSAMEALGKTPAILKSGRQDAAFYQAMWETLNRDK-WQGELWNRRKNGEIYPEWLTITAV
LDGDGRVTNYVGVFSDITLRKEADEKIHQLAFYDPLTGLPNRRLLHDRLQQAMTSSVRSQCKGALLFLDLDNFKVLNDTRGHDIGDLLLIEVAKCLRDCV
RSGDTVARIGGDEFIIMLENLSETQAQDVGEKVLKAINHSFSLQGVDYHCSSSIGINLFHGNDTGMDDLLRHADTAMYQAKASGRNTLRFFDPAMQIELE
ERTALMEDLRQALPLQQLRLYHQIQVNE-RG-VVGSEVLLRWQHPVRGLISPMEFIPLAEETGLIVPIGAWVLHMACVQLKAWQVDPLRHLRIAVNVSAR
QFSQPDFVEQVLEVLKDTGVNPLKLELELTESLVLNDIDDSIGKMQALRSIGIRFSLDDFGTGQSSLSYLKRLPLDQIKIDQSFVRDIATDPNDAAIVRT
IIGMAENLGLKVIAEGVETEQQREFLERNGCHAHQGYLFGKPVPIDEFQNSLTQLHR---
>tr|C9Y691|C9Y691_9BURK Uncharacterized signaling protein PA1727 (Fragment) OS=Curvibacter putative symbiont of Hydra magnipapillata GN=Csp_E34680 PE=4
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------T-------GREVPVLTGHAAVKELFRFDIDLSERK-
-----------FE-AQEGMMVTDAHRRILRVNEAFTRISGYEDVEVIGNTPTMFSSGWHDNAFYEELNASLASTG-WQGEMWNRRKNGEIHPQWLHITAV
NDETGAVSHFVATVTDITQRKAAEDQIRQLAFYDPLTGLPNRRMLIDRLRHALASSARSAHCGALLFIDLDHFKNLNDTLGHDKGDLLLQQVAQRLLDTV
REEDTVARLGGDEYVVMLEGLDEHDATAVGEKIIAKLNWPYQLAGHEFHSTPSMGLTLFNGHEVEVEDLLKQADLAMYQAKGAGRNGLRFYDPQMQAAVT
KRAELEADIRQGILFGQFVLFFQPQVDK-SGCVMGAEALLRWNHPTRGMVSPAEFIPVAEDSGQILTLGSWILEAACAQLVAWAADPERALTLAVNVSSR
QFRQQDFAQHILDMLDYTGANPHCLKLELTESLLADNLDDVIVKMSALRARGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDVLTDPNDAAIVQT
ILALGKTLGLKVIAEGVETGEQRDFLVANGCNSYQGYLYSRPVPADEFLRYVHAVSV---
>tr|G8QI35|G8QI35_AZOSU PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Azospira oryzae (strain ATCC BAA-33 / DSM 13638 / PS)
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------KSGEVFWASVSLSLSRNEAGEPAGLIGYLVDITNQL-
-----------FEHNSEAVIVTDAMQRVLSVNKAFCDITGFSEAEVRMSLPALLQPTRDDPNLAAEIQVALASSG-WQGELWDRRKNGDTYPVWVSISSV
KNTRGILSHYFLVFSDISERKEAERQIYRLAYYDALTGLPNRSLLFSLLEQALIEAQRNQTHGAVLFVDLDRFKTINDSFGHAPADALLKEVARRLQETL
RAEDVVARLGGDEFIVALFDITKEHAALVGQKILDALAEPFQIVHHEVLLTASIGIAVFPDDGRDAETLLRNADTAMYRVKQTSGG--LFYSQEMNLRSL
ERLKLEGALRKAVERQEFRLYYQPQVELATGRIVGAEALIRWHHPEQGMIPPTAFIPLAEETGLIVSIGAWVLDAACRQGRLWREAGYEDLTIAVNLSPR
QFR-PGLSQLVNETLERHAFPGENLELEITEGMLMHNSEAVIQMLEDFHQAGVRLALDDFGTGYSSLAYLKKFPIDNLKIDRSFVSGIPHDGDDSAIAKA
IISMAKNLRLLVIAEGVETEEQLDFLRAAGCDEIQGYLFSPPVPVEDFQLLLERNNG---
>tr|A0A081C1J6|A0A081C1J6_9BACT Sensory box/GGDEF family protein OS=bacterium UASB270 GN=U27_05425 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------HDELERWLEERTTELMNANEQL------AEEIEERK-
-----------LESVPDPVVVYDMEGKVAYFNPAFSRVFGWSLSEGIGCAINFVPVEHLSEV--RLIFE-KIQRG-MVSGIETTRLTKDGTPVEVSISGF
FDHSGTLQGSVLTIQDITARKKTEQEIRYIAYHDILTGLHNRKSFYMRLEDQLLQSQSSHLKWAILFLDLDRFKYVNDTLGHDVGDELLKMVSKRLQAHL
RKSDYLFRLGGDEFTILLNGVTNTDVAKVAKKLREEIARPYLIHDHEIYISVSIGISIYPVDGENVERLVKNADMAMYAAKEE-RQGFRFFTEEMNKIAL
ERMMLEGSLRNALRDNQFIIYYQPLVDK-RERIIGSEALLRWHHPEIGLISPSKFIPLAEETGVIIQIGKWVLASACLQAKVWYDRGYTEFYVAVNLSTR
QFREPDLVETIEQVLEDIGLPPHCLKLEVTESGIMENPEQAIEKMRQLRQIGIHFSIDDFGTGYSSLSYLKRFPIDTLKIDRSFVIDSTTNKDDQEIIKT
IIAMARNLKLSTVAEGVETKEQQDFLVTQGCQMMQGYYFGEPMPAEAFEVILQARKF---
>tr|G4STP3|G4STP3_META2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 /
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------DGTYRWIHDKSIMTRTSTGQIDEVFGAWMDVTEHK-
-----------FE-SLQGIMITDPDATILRVNQAFTTVTGYAAEEVIGKNPNILHSDQHDQLFYEDLWRQLQIDG-FEGEIWDRRKDGSIFPIWQCITAV
KNNRGETTHYVAVFTDLSEKKKFEEYISQLAFYDPLTDLPNRRLLLERIEQVLIQAKRKNTYAAILYMDLDRFKVLNDSMGHQTGDELLVQVAKRLKQSI
RQEDTPTRLGGDEFVILVHTDTNQDILNLAEKIMRKLNEPYLIKGNEHYFSSSMGVTLFSGQCQVATDLLQQADTAMYRSKEKGRNTISFFDRSMQEAAD
KRLQIENALRMAIEQQQFMLYFQPQVDR-TGRIISAEALIRWNHPDKGLIAPNEFIPIAEETGMIQQIGAWVIEAACSQIKLWQQAGR-YAYLSINVSSQ
QFRQKDFVTNVRRAIVQADIESSRLMIEITESVLMQDINDTVEKMQALTKLGIAISIDDFGTGYSSLAYLTQFPLSQLKIDQRFVKNIDADKNSAVIVET
IIAMAGNLGLKVVAEGVETERQLMFLVDKGCVVFQGYFFGKPVRYMSMI---LRHP----
>tr|F9ZVN1|F9ZVN1_METMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomonas methanica (strain MC09) GN=Metme_1075 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------QGDWRWILDHGVPIYDEKGVFAGYIGSAFDITERK-
-----------FE-SQEAMVITDANAVILRVNKTFTESTGYSAEEAVGQNISILKSGRHDQDFYADMWRSLKNTG-WQGEIWDKRKNDQIYPKWLTITAV
KDETGAVTHYVGTHIDISDRKAAEDEIKNLAFYDPLTQLPNRRLLLDRLQQALATHARKQVFGALFFLDLDHFKNLNDTLGHEKGDQLLQQVAGRLSSCV
REGDTVARLGGDEFVVMLKELGASAAEMIGEKILRTLNETYQFDGYEHRSTSSIGATLFSDQSLGIDELLKQADIAMYQAKAAGRNNLRFFDPAMQASII
ARTAMEQALHEALNAKQFRIFYQPQVDA-EGRIYGAEALLRWEHPTQGMVSPASFIPLAEETGLILPLGHCVLENTCEQLVKWASLPGAHLTIAVNVSIR
QFRQDDFADQVLAILAKAGANPARLKLELTESILALDLQDIKSKMTRLKAQGVTFSLDDFGTGYSSLAYLKQLPLDQLKIDQSFVRDILNDVNDEAIAKM
IIALAASMGLQVIAEGVETTLQKDKLLDLGCANYQGYLFSRPVAIDEFEALINSR-----
>tr|C6WUG6|C6WUG6_METML Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylotenera mobilis (strain JLW8 / ATCC BAA-1282 / DSM 17540)
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------KRTFLQIKT-PIYENEADRKIWGLCGISTDITALK-
-----------FE-SSDGILITDAGCSILQVNSAFTTITGYSAEDVVGKNPRILSSGRHDQLFYQALWDRVNTTG-WCGEIWNRRKNGDIYPERITISEV
KDKDGKVTNYVSVFTDISESKASSEQIEHLAFYDPLTNLPNRLLLLDRVRQAFSSSSRTGKKGALLFVDLDHFKVLNDTLGHSTGDLLLKLQAERLSHCV
RAGDTVARFGGDEFVVVLEDLDRATAEQIGNKILSTLHEPCQFGTHQYQSTSSIGITLFSGDEHEIEDLLKQADISMYQAKKAGRNTLRFFDPAMQEKLS
VRASLESELRYAIEKQQLALYYQVQVDD-NQRMVGAEALIRWIHPERGTVSPIEFIPIAEESALILDVGHWVINTACMQLAEWAKSVEKHLMIAVNVSAH
QFRALDFVQSTQQAIDLHKIDASRLKLELTESVILEDVDDVIAKMHALKALGVKLSLDDFGTGYSSLSYLKKLPLDQVKIDQSFVRDLAYDPNDAIMVKT
IIDLANNFRINVIAEGVETELELDILKGYGCRLYQGYLFGRPVPIEQLQFAAT-------
>tr|V5C142|V5C142_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methyloglobulus morosus KoM1 GN=MGMO_9c00050 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------DGSWHWILDKAIPTFNDGGKFTGYIGSAIDITERK-
-----------FE-TQEAMVITDADRIIMQVNKAFTESTDYTADETVGQHMDMLKSGQHDEAFYTVMWESVEHTG-WQGEIWERRKNGEIYPNWLVITSA
KGHNGVVSHYVCTHIDITERKLAEEKIKKLAFFDPLTQLPNRRLLMERLKYGIELARREGRQLAMLMLDLDRFKAVNDSYGHQAGDQLLQLVAVRLKTRL
RAVDTIARWGGDEFIVLLENITHDDAGRIAEEIHAELTKPFQLLQDDVRIGASIGICLYPQHADNAELLLDYVDAALYLSKDQGRGGIAYFSEEITRAIR
ERIALEARLRRAIGHQELRVYYQPQIDIASGRMVGAEALVRWQDPDEGLIPPSLFIPIAEESSLIVKIGEWVLRETCRQGRLWLD-MGPPMTLAVNVSPH
QFRRSDINALVATVLAETGFPAGQLELEITESGLMANQDNATNILNNLHAQGVRLAIDDFGTGYSSLAYLKHFPLDVLKIDKSFIDEIPHNKDDMEIAAT
IVAMGHTLGFKVLAEGVETPEQLAFLQKAGCDVYQGYIKSRPIPAEEFAELLLEQQG---
>tr|A7IP89|A7IP89_XANP2 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------SRDVRWR---GLATRDGDGAVTRVVGMITDVTAQK-
-----------FASAHDGLVVTDLNAVVSAVNPAFSQITGYCEAEILGRSMRTMHSGRHDREFYRGMWGALTSTG-WHGEIWNRRKNGEIFLQQLSIRTV
FDEKGKPQNYVGAFQDITRIKHSEFELDRIAHYDPLTDLPNRTLLASLLDLAV---SRAGKTCAVLFLDIDRFKTVNDSLGHIAGDAVLKAAADRIRAAL
DADATLGHYGADEFVVILEEIEGQDAALAASRLIDELARPFTINGGEIYLGASVGISLHPLDADDAAQLLQHANTALAEAKAQGRGIYSFYTQALTRSAR
VRMEMEADLRRGLVREEFRLNFQPVVDLANGRIAGAEALVRWQSPVHGLVLPNRFIPLAEETGLIEPLGDWVLEEACQQMAKWTAAGALD-FIAVNLSPR
QFQRGTLCERIEEVLRRTGLPAARLEVEITENVLFGAVA-AERKLRDMRDSGVRIALDDFGTGYSSLAYLKRFPISKLKIDRSFVHDLPR-AADAEIATA
IISIARALGLDVVAEGIEAPEQCAFLKERGCGFGQGYLFGRPVTSERFLRLALQGPI---
>tr|Q1NRG2|Q1NRG2_9DELT PAS:GGDEF:EAL:Response regulator receiver OS=delta proteobacterium MLMS-1 GN=MldDRAFT_4278 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------QEGAYDFLIK-PCPPETIIAALKKQLRQNIREGEER-
-----------ET-LGDAVVVIGRDLRIITANRGYRQQSGRGEEEIIGQHCYRISHGYSRPCWLEE-DCVAIKEG-PANSIHHRDKEG--VPLYVETNPL
RDQNG-IYAAVETIRDITEIKAKEAEIERLAFYDFLTDLPNRRLLQDRLEQAFAASERSGQYGAVIFLDLDNFKNVNDTRGHRTGDLILQMTARRLRDTV
REDDTVARLGGDEFVILLSNLATSEVGRVAEKIRLALARPFKLIKGEFHLGASLGIALFRGHENSAEELFKYADTAMYRAKEAGRNTARFFDPAMQTALE
ENESLERDLRRAVVQEQFELYYQPQVDA-AGRLLGAEALLRWYHSARGPVSPLSFIPLSEENGLILPIGRWVLQEACRQLAAWSQSFPGDFRLAINVSAR
QFHQPGFVDEVQEIIAAARVEPRQIKLELTETLVLTDLDDTIKKMRQLQAAGLGFAMDDFGTGYSSLAKLKQLPLEQLKIDRAFVRDLETDPHDAAIAAT
IIAMGRTLGFEIVAEGVESAEQLQILQSQGCGIFQGYYFTPPLPAAKFERLWRGERG---
>tr|D6Z440|D6Z440_DESAT Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfurivibrio alkaliphi
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------REGAYDFLTK-PCPTDTLIAAVKKKLQWIIESAEER-
-----------ES-LGEAVVVIGRDMRIISANQGYRHQTGREDEEIIGRHCYEISHGYSRPCWLEEEGCVCFQDG-HHTAIHHRDKEG--NPIYVETNPL
RPGDGMIYAAVETIRDITELKRKEVEVYRLAFYDPLTGLPNRRLLLDRLGQAFAASERTGQHGALLFLDLDRFKNINDTRGHQAGDLILREAARRLRATV
REDDTVSRQGGDEFVVLLQYLATDAAGRVAEKIRLALSKPFQFSECRFHLSASIGVTLFVGHQLSAEDLFKYADTAMYQAKQAGRDTVRFHDPAMQQALE
EAEELERELRRAIDEEHFALHYQPQMDA-HGRLLGAEALLRWVHPERGLITPLAFIPLAEENGMILPIGSWVLHAACAQLAAWSGRPGENFRLAVNVSPR
QFHQPNFVGEVEEVIGSTGIDPRRLKLELTESLVLADLNDTIVKMEQLRALGVGFAMDDFGTGYSSLAKLKQLPLEQLKIDRAFIRDLENDPQDAAIVET
IIAMGRTLGFEIVAEGVENEQQLHFLQQHGCHMFQGYYFSPPVSAAKFEKFG--------
>tr|K9DWU2|K9DWU2_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia timonae CCUG 45783 GN=HMPREF9710_02942 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------EVGASDYVFMPVAPEV-LKAKVQAF---LDGAPERRP
VRA--------LEHAGDYVALLDPAGAWLYTSPSYRAEFGAAV----GPGARYLEIVQVDRERVRALVEHPAGES-WRLQYRLGR-----SERYFESDLI
RAPNGAVSQLVLISRDITERKEMEAYVLHQSFHDSLTGLPNRLLLLDRLGQATAQRERQRAQVAVLFLDLDHFKEVNDTLGHAAGDRLLQVVAERLAASV
REGDTVARVGGDEFVVMLVELHQADAALVAEKIISAVSEACQIEGSELHIVPSIGMAIFPGDGGDPDTLLRNADIAMYHAKRDGGAHYCFFTAQMQEVAS
HRLALGSALQRAIRNDEFVMHYQPKVQAASGAIIGFEALIRWPQADGATISPSQFIPIAEETGRIDPIGAWAIRQVAAELQRWTGLGFADVPIAVNVSAL
QFRREDVARCLGAAVDAARIEPAMLEVELTESGVMSNPAQAIETLHQIHALGMTIAIDDFGTGYSSLAYLKRFPIDKLKIDASFVRDIATDPSDAAIVLA
IIGLAHVLELTVIAEGVETREQVDFLVAHGCDELQGNYFSAAVSNEDAVGLLRRGPF---
>tr|A0A0D2W1F4|A0A0D2W1F4_9PROT Skermanella aerolata KACC 11604 strain 5416T-32 contig11, whole genome shotgun sequence OS=Skermanella aerolata KACC 11604 GN=N
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------RAGTVVGYM-ASIEDTDRQQ
ALDILLRRESLLDAAVDGILTIDARGVIQSVNRACCQMFGFDEIELVGAPIAMLMPASHRHAGYVDNSSGRAKIIGTGREVLAQRKDGSVVPIHLSVGEM
R--FGDEVTFIGIARDVSDRHAAEERARFLTNHDPLTGLLTRRAFLEQCDREMAVRLPSDMAHVVFSFDVDQFREINEGLGYHIGDGVLKAIVARFAEVL
PRDSVLCRVGADEFAALARFPNRIAAEDIADQVHARLLSPIYVDRQLVLVRMSIGAAVYDPSIKRVEELLTKAELALQTVQHQGGNGVCFYTPEMALAAS
RRTLLTMHLAHAVQRNELNVVFQPIIEAKSGRVAGAEALLRWSHTNLGAVSPAEFIPIAEDSGLIVSITDWVLEAVADQVDRWHGEGVQCGRVFMNVSGQ
QFLRGRLTTRLAELMKEKPHLAGLIGIEITEQAAVRDLKATVQAISELASISVETAIDDFGTGYSSLSYVQQLPITKLKIDRMFVDGVPHNRKNSALVRA
VVGMAHGLGLTVVAEGVETLAQRDFLTDVGCDLLQGYLFSQPVPPKTLVILIGDQP----
>tr|W9GZY2|W9GZY2_9PROT Diguanylate cyclase OS=Skermanella stibiiresistens SB22 GN=N825_06660 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------RGGAVIGFI-AFLEDSERQR
HLDVLLRRESLLDAAVDGILTIDARGVIQSVNHACCRMFGFDEIELVGMPVAILMPAPHRHAGYLDSASGRAKIIGTGREVLAKRKDGSVFPVHLSVGEM
R--FNDEVTFIGIARDVSDRHAAEERARFLTNHDPLTGLLSRRAFLEECDRLMAIRLPGERAHVVFSFDLDQFREINEGLGYHVGDGVLKAIVLRFREIM
PKDSILCRVGADEFAALAMFKDHEVAEESADHIHDRLLSPIQVDRQTVMVRMSIGAAIHDPSIKRVEELLTKAELALQTAQHQGGNIVCFYTPEMAQAAS
RRTLLTMHLAHAVQRNEFKVVYQPIIEARTGKVAGAEALLRWTHTQLGAVSPTEFIPIAEDSGLIVSITDWVLEAVADQVALWHDEGLCCGRVFMNVSGQ
QFLRGRLTTRLAELMREKPYLAGLIGIEITEQAAVRDLKATVQAISALSSISVETAIDDFGTGYSSLSYVQQLPITKLKIDRMFVDGVPHNRKNSALVRA
VVGMAHGLGLTVVAEGVETVEQRDFLGEVGCDLLQGYLFSQPIPTVAFSLLLRDQP----
>tr|G7Z4K8|G7Z4K8_AZOL4 Putative diguanylate cyclase/phosphodiesterase with PAS/PAC domain OS=Azospirillum lipoferum (strain 4B) GN=AZOLI_1046 PE=4 SV=
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------ADGETVGYL-GTFHQGDPDR
IAEFVTCRDTLLDAAVDGIIVSDRSGIIRSINRACCQMFGYDEGELVGRNMTILMPPPFDHNRYIDSKTDRARIIGIGRDTLGQRKDGTVFPIHLSVGQA
R--LGEEMTFVGIIRDISDRLAAEQRATYLARHDPLTGVLTRTAFLEDCEALFAEHGTAGELFALFSLDVDQFSDVNEAFGFHVGDAALKAMVSRVMEVL
PPNTIVCRIAADEFAALSRVTDGEHARTLAGVLHDRLTASIYADRHWVRLRLSVGAAVQDESVSTLEDMNAKAKLALQAVQHNGGNAVCFYTPEMAAAAT
RRMLLTMHLTHAIERNELHLVYQPIVD-RHGRVRSAEALLRWSHHALGPVSPGEFIPVAEESGLIVPITDWVLATAVGQMSQWEDEGVLPDRVFLNISGQ
QFLRGNLTLRLEELLGRHPSLRSHLGLEITEQAAVRDLKVAVRTLGELADLGIQAAIDDFGSGYSSLSYVQQLPVAKLKIDRAFIIDVPDNPKNNALVRA
AVGMAHGLGLTTVAEGVETAEQRDFLVSVGCDLMQGYFFGRPMAPEALADLLRGQG----
>tr|N6X9U1|N6X9U1_9RHOO PAS domain-containing protein/PAC and GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Thauera sp. 27 GN=B447_185
-----------------------------------------------------------------------LIESVRRNEAALKQDIVERMRV----EA-
-ALRASEEKHRVLFETSRDAIMTLAPSWRFALFGADDEADAREMMETALAEGS-LLFEWEHRRLNGVTFLTSVLLSRFEL--GGHTMLQAHVRDITERRK
AEESMRLAANVFTHAREGIVITDRDANILEVNPAFTDITGYQREDVLGQNPRILSSGKQDQAFYAAMWQELNTKGSWSGEVWNRRKDGRVYAEMLTISAV
RDERGEIKHFISLLSDITALKEYQNELEHIAHYDGLTGLPNRLLLADRLRQAMNQAPRRNKRVAVAYLDLDGFKSINDNHGHEVGDHLLATLAKRLAQVL
RNGDTLSRIGGDEFVAVFVDLPDEASVPMLTRLLDAAAQPVAHGDTMLHVSASLGVTFFPQSEIDADQLLRQADQAMYQAKQAGKNRYHIFDAEQDRNVR
GLHESLEHIRQALAQRQFVLHYQPKVNMRTGALVGAEALIRWQHPQRGLLPPAAFLPVIEGHPLAIDVGEWVIDTALQQIEAWRTDGLS-VPVSVNVGAL
QLQQADFVSRLRALMAHPGVQPGELELEILETSALEDIAVVSQVMEACHDMGVGFALDDFGTGYSSLSYLKQLPAGLLKIDRSFVRDMLNDPEDLAILEG
VLGLARAFRRQTIAEGVETLPHGEMLLRMGCEWGQGYAIARPMPAQELKRWMGSW-----
>tr|Q21WZ5|Q21WZ5_RHOFT Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 152
-----------------------------------------------------------------------LLAHLHQRETLLKQILDTSSAAIFVIDSQ
GRITQANQRMAEMFGCPLDTSSDLESFWGHLLLSGDGVSDMRDSFRTLIEEGKAPLIDEKYLRLDGTPIDVEVQSTSIIY--EGLAAIRTAFRDISERKL
AHDKLQLAANVFSHAREGIAITDARATIIDVNEAFCRITGYSRDEVLGQNPRVLGSGRQDKAFYAAMWHDLGEQGHWYGEIWNRRKNGELYPEMLTISAV
RTDQGQVQNYVALFSDISAIKAHQHELEHIAHFDALTNLPNRVLLADRLQQAMAQAQRRGQMLALAYLDLDGFKAINDRHGHEAGDLLLMTVATRMKQTL
REGDTLARIGGDEFVAVLLDLSDKASAPMLSRLLAAAAEPVRLGDLALQVSASLGVTFYPQVDMEADQLLRQADQAMYQAKLAGKNRYHFFDAAQDRSAR
GHHESLERIRQALDRREFVLYYQPKVNMRTGAVIGAEALIRWQHPEKGLLAPALFLPVIEDHPLAVDIGEWVIATALIQNELWQADGLD-MPISVNVGAR
QLQQADFVPRLRELLAQPGVKPFQLEIEVLETSALEDWVGVSQSIEECREMGVLFALDDFGTGYSSLTYLKRLQVDLLKIDQSFVRDMLDDPDDMAILQG
VIGLAGAFRRNVIAEGVETIAHGTLLLQLGCDLGQGFGIARPMPADLFPAWAASW-----
>tr|A0A084XWD1|A0A084XWD1_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-01 GN=gmr_11 PE=4 SV=1
-----------------------------------------------------------------------QLLTLGQREDALKE--SKAPLAYQSLDAA
GNILQVNNAWLKLFGFTHDE---------------------------------LDGPVFDIRRKDGSSRLVEVNGRIGYDSEGNFCQTHCILTDITDRTR
AEAALLESEERWKGAGEGVWDWNIQTGDAVYSRRWKEMLGFAEGE-IGNNSSEWSSRVHPEDMAAIEFRMMCKDGSWL---WTLG---------RGMVVS
RDASGKPLRLVGTNADISERKASADKIERLAFYDPLTDLPNRRLLRDRLEQALASSTRRNRHGALMLLDMDDFKTLNDTLGHDVGDQFLVEVARRLQASV
REGDTVARHGGDEFVVILEDLSEAQAESVAEKILHVVSQPYLLDLCSYHCTSSIGITLFRGHSLSADELMKHADTAMYQAKAGGRNSLRFFDPEMQAIVA
ARATLDSDLREAVREGQFCLYYQPQVDS-AGNRTGAEALVRWQHPRRGLVSPGEFIPQAEATGLIIPIGHWVLETACAQLVSWETVPSH-LTVAVNVSAR
QFRHVDFVGQVLAIIDSTGVNPQKLKLELTESLLLDDVEDIISKMTVLKAKGIGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDVLTDPNDAAIART
IVALAQSMGLAVIAEGVETEAQREFLAANGCSAYQGYLYGRPMPLGEFSQQTG-A-----
>tr|N6XEN5|N6XEN5_9RHOO PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Thauera sp. 63 GN=C664_00600 PE=4 SV=1
-----------------------------------------------------------------------LLGRIEQQEAQAIEIVSNVPGMVFQYRRQ
DAFLFASEGAMAIYGVPADA---------------------------------MWQVDYRIRREDGRIHWLRVDALPERDPEGVV-TWFGVVTDITTTKQ
MEAELRIAATTFQ-SHEGLFITDTQGVILRVNRAFSEITGYTEQEVIGRTPSILRSGRHDSSFYAQMWQQLAQAGVWSGEIWNKRKSGEVYPEWVTISAV
KDADGTISHYVAAFRDITERKETEERIYRLAYFDALTNLPNRRLLGDRIQHAIVSSQRSHECCALFFLDIDHFKLLNDTKGHDVGDRLLADIAMRLTAAL
RNEDTVARLGGDEFVVMLERLSTPSAALVAEKLRAVIAEPYDLDGYRHLTTSSIGVTIFQGEGQQVDALLKQADVALYEAKAAGRNTARFFDPAMQHQIN
ERLALEAALREAIEQRRLALWYQPQVDA-GGTTLGAEALLRWIDKDGRIIPTDRFIPLAEETGLIHPIGRFVLHAACQQLAAWASDPSE-IVLAINISAR
QFAEPDFVTELQAMLAEHHVPRGRLKLELTESVVLERVDEAVQRMQQLRALGLLFALDDFGTGYSSLSYLKRLPVDQVKIDKAFVRDVCEDAGDAAIART
IVTLGHVLGISIIAEGVETEAQLDFLQACGCDAYQGYLFGKPMPVSQFERFAA-A-----
>tr|Q21ZN9|Q21ZN9_RHOFT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T11
-----------------------------------------------------------------------LLQTLTRREESLKE--SNSHDVIYTLTKA
GVFTFMSSAWTALLGHPLNQ---------------------------------VEGIELRLRHLDGGWRWFHTNAVPLKNETGKVIGLQGSAMDVTVRKL
AEEDTRIAATAFE-SQQGMIITNAEKVILRVNKAFTEITGYTMEEALGQTPRLLKSDRHDAGFYGAMWASVARSGSWQGEIWRQRKSGEQYPEWLSINAV
KDAAGLVTHYVGVFSDITERKISEEKIDRLAFYDALTGLPNRRLMIDRLQQALAATARHHCKGALLLVDLDNFKTLNDTLGHDQGDLLLQHAARRLSACL
RESDTVARVGGDEFIVLMEDMSQDQAKALGEKIIDTLGQPYQFGSSSHYSTASIGITLFDGAQESTEEPMKQVELAMYQAKAAGRNTLRFFDPQMQAVVT
ARAVLENGLREALEQNQFLLHYQAQMVG-GRQITGVEALVRWRDPRRGMVSPVEFIPLAEETGLILSLGQWVLETACTQLARWATRAEH-LTVAVNVSAN
QFQQGDFVEQVLAVLERTGANPNRLKLELTESMLISNVEGVIAKMSALKGRGVCFSLDDFGTGYSSLSYLKRLPLDQLKIDQGFVRDILIDSNDAAIAKM
VIALAESLGLSVIAEGVETEAQRDFLAGLGCHAYQGYLFCKPLPLEEFEAFLQ-R-----
>tr|Q21R50|Q21R50_RHOFT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T11
-----------------------------------------------------------------------LLGTLGQREALLQ----TSSVAIFLVDRQ
GRITKANQRMATLFGYPLHE---------------------------------VVDLERLYWRADQTEFWGHLTGQRFVDGNGEEQGLVGVIADITQRRQ
TEAELRIAAIAFE-SEQGMAITDPQGVMLRVNRAFSAITGYSAPEAVGQNPRLLSSGRHDAAFYAAMWDSLVREGAWQGEIWNRRKNGEVFPEWLTISAV
KDPAGQATHYVATFTDLSTRKSAEDQIKSLAFYDTLTGLPNRRLLLDRLKQALASGARHRRQGALLYIDLDDFKTLNNTYGHDVGDQLLQEVAQRLSHYL
RAGDTVARPGGDSFVVLLEALSTSEAENTGEKIRLALSQPYQIADHAHRSTASIGVTLFDDRQEGIDEPLKRAELAMYQAKTAGRNTLRFFDPQMQTAVM
AMAALEADLREAVRSNQFLLYYQAQVSG-ERQVAGVEALVRWQHPVRGLVPPAEFIPLAEQTGLILPLGQWVLETACAQLAAWASQPAH-LTVAVNVSAL
QFHQADFVAQVLAALKRAGANPQRLKLELTESLLVHDAEDVIAKMITLKEQGVGFSLDDFGTGYSSLSYLKRLPLNQLKIDQGFVRDILHDANDAAIAKM
VVALADTLGLSVIAEGVETEAQRDFLAAQGCHAYQGHLYSRALPIDAFEAFMR-Q-----
>tr|H0Q2U2|H0Q2U2_9RHOO Uncharacterized protein OS=Azoarcus sp. KH32C GN=AZKH_0391 PE=4 SV=1
-----------------------------------------------------------------------EVVTLADQPLFANAMLDHDGDAWL-R---
------------IAVPILYR-----T-----------EAL-------------AYNH-EHRLLVGGETRWVHAQAESNFDAGGRLVRSVGTLQDVTLRRQ
TEARMREALAVFEASSQGIMTTDARGVIVSVNPAFCRITGYTVGEVVGRTPSVLRSGRHDQAFYHAMWSRLLDDGQWEGEVWNRRRSGEVYPEWLTISAV
RDVAGRVVEFVALFSDISERKEHEEVIWRQANFDALTGLANRSLLHDRMELALLQQRRAGQKMGLLFLDLDGFKWVNDTLGHNVGDELLIEVAQRLKGCV
REHDTVARLGGDEFTIVVTGLHDDVLRSIGEKILDVLREPFTLGGGSHHISCSVGITVFPDDGGDVQILLRNADIAMYKSKQAGKNRLHFYAPQMQADVA
AHLEMQAELRKAIAAEAFVLEYQPIIDAGSGELAGAEALIRWEHTERGRIPPAQFIPVAEECGLIVAIGEWALRAAARQWRSWYDAGRD-LRLAVNVSGM
QFRDASLPPLVAEVIREWGIVRGALVLEICESVLMDGSVQAQARMREIKEQGIGYALDDFGTGFSSLSYLKRFPVDVVKIDRSFVSGCPDDRNDAHLVEA
IINMTHSLGLKVVAEGVETEAQRAFLRALGCDQLQGYLIGRPMSAEAFLRLIEAR-----
>tr|W6M6B8|W6M6B8_9GAMM Putative Diguanylate cyclase OS=Candidatus Contendobacter odensis Run_B_J11 GN=BN874_570015 PE=4 SV=1
-----------------------------------------------------------------------FQARIRDNENLLREQRSSLNDAVF-L--H
GRILFVNAKASEMFGYTREAEGEPQ--------------DLQESYRSLLALGLPYLEEIQLKRKDGSIFWGYLHGRALDLN-YPENGSVWIYTDQTDQKQ
AQEHLQLAASVFENAAEGIMITGADDIILAINQAFTEITGYTAEDVVGNKPDLFKSGRQDAVFYQQMWQALVRNGEWRGEIWNRRKNGEIYPEILSIQAI
KDKAGRITNYIAMFTDIAEKKRSENQLAFLIHHDPLTELPNRVLFTDRLDHGIQRTVRGQARLAVLFIDLDHFKTVNDSLGHPLGDQALQMIARQLTQAV
RTSDTLARLGGDKFILMIEDINGQDTVLIAQKLLNTFTQPFILAGYELYLSASIGISIYPTDGNDAHELIKNAEAAMYQAKAKGRNNYHYYAREMTADAA
ERLQLESMLRRSIERNELVVYFQPQVDLASGALIGAEALVRWQHPTLGLIPPIKFIPLAEETGFISALGEWVLRNACLKLKTWRAAGQL-PKVSVNLSIK
QFERGDVVHLVEKILTATGLPPECLELEITESFVVN-ADDAFGFIAELKALGISLSVDDFGTGYSSLMYLKNLPIQQLKIDRSFVMDIGQDTNNEAIVRT
IIALAKNLGLAVIAEGVETKAQADFLLSEGCPQGQGYYYDKPLPEKEFVERWLAR-----
>tr|F4GD41|F4GD41_ALIDK Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Alicycliphilus denitrificans (strain DSM 14773 / CIP 
---------------------------------------------------------------RRVRALGDVGVALRESEERFRAVFSQAAVGMAQVDLH
DRMVRVNRKLCDLLGYTEAELQQLR---FQDISDPRDLDADLAF-MERMRSISEFRMEKRYCRKDGEIVWAELMVSRLCLEGRP-ESHLAVVQDIGERKQ
MEQALSDSEQHLLGMPVGVNLVR-GRAIAFRNDRHVQICGYGEQEAPDVDSWWRLVMPDERHQAREAWKAARDGAIRPVECHITSKAGLLRTVEISGVML
E------DSHIVTMVDQSQRRQAEEEVRYLAYNDPLTGLPNRRLLLDRLQQALAMSARHQLCGAVLMLDLDNFKHINETQGHDMGDRLLHAVALRLRACI
PEDDTLARHGGDEFVVVLKDLGAQRAEAMGLQILDAMREPFALGGEPRHTTLSVGIVIFQGLHESADELLKRSDMAMYEAKAAGRDALRFFDPQVQAQMT
ARVALEADMRSGLEAGEFELFYQPKMV--HGRITGAEALLRWKHPVKGYIPPSEFIPLAEQSGLILRMGQWVLRTACERLALWSSHPLGQLSVAVNVSPR
QFHEAGFVPEVLEALAGTGADARRLRLELTEGLLLQDVEDTVAKMVQLRGYGVGFSLDDFGTGYSSLAYLKRLPLHELKIDQSFVRDVLTDPNDAAIART
IVALGTSLGLQVVAEGVETEAQRVFLERSGCHAWQGYLLSRPLPGLAFEDLVLEHA----
>tr|A1W7N9|A1W7N9_ACISJ Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Acidovorax sp. (strain JS42) GN=Ajs_2088 PE=4 SV=1
---------------------------------------------------------------RRSQALDHADTALRESEARLRAVFNQAAVGIAQTDSR
GRLVRMNQKFCDLLGYSAQELQQMR---FQDFSEPSDLAADLEQ-LQRMLALSEYRMEKRYRRKDGSEVWVDLMVSPLRLEGQP-EHHLAVVQDISKRKH
MEQVLRQSEEPLRNMPVGVNQVQ-DGKIVFRNDRHVQICGYDIREAPDVDTWWRLVMPDQREHAREAWHAALDGAIRTVECVITAKSGVRRAVELSGMIL
G------DSHIVTMVDQSQRKAAEEEVRYLAYNDPLTGLPNRRLLLDRLEQALAMSARHQLCGAVMMLDLDNFKTINETQGPDMGDRLLREVARRLRDCV
PEDETLARHGGDEFVVVLKDLGAQRAEEMGQTILAAIRAPFDIDGQQHHTALSVGIAIFRGVRESADELLKRSDLAMYEAKAAGRDTLRFFDPQMQAAVS
ERAALEADLRAGLDAGQLELFYQPKVD--QGRITGAEALVRWRHPDRGFISPAEFIPLAEESGLILRVGEWVMRSACAQLAQWSAHPLGELTVAVNVSPR
QFHEGSFVPQVLEALAASGADARRLRLELTEGMLLQDVEDTIAKMVQLRGYGVGFSLDDFGTGYSSLAYLKRLPLHELKIDKSFVRDVLTDPNDAVIART
IVALGTSLGLRVVAEGVETEAQRAFLERNGCHAWQGYLLSPPLQAAAFEALVLKRA----
>tr|A0A0A1VKE1|A0A0A1VKE1_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor OS=Acidovorax sp. MR-S7 GN=AVS7_03895 PE=4 SV=1
---------------------------------------------------------------RRAQALDHVDTALRDSEERFRAVFNQAAVGMAQADSR
GRLVRVNQKFCDILGYEAQELQQMR---LQDFSHPEDLQEGQAL-LERMLAISEFHMEKRYRHKDGHFVWADLTASPLRIDGGRAGFYIAVVQDISERKQ
MEDALRGSEHHLRNMPAGVNLVQ-NGAIVFRNDRHVQICGYGAEEAPDVDTWWRLVVPDQRQRAQSEWRTAQDGAIRPVECVITAKSGQTRTIELSGMRL
G------DSHIVTMVDLSQRKAAEEEIRYLAYYDPLTGLPNRRLLLDRLQQALALSARHQRCGAVLMLDLDHFKTINETQGHEMGDRLLREVADRLRCCA
EKDDTLARLGGDEFVVVLTDLDGQRAEEVGTRILAALRGPFQLDGEQHHTTLSVGITLFQGLRESVDELLKRSDLAMYEAKAAGRNTLRFYDPQMQAAVA
ARVALEADMRAGLEGGQFELFYQPKMV--HGRIIGSEGLLRWRHPDKGFIPPSQFIPLAEDCGLILPLGEWVLGTACERLARWSAHPLGQLTLAVNVSPR
QFHEPSFVPQVLAALAGSGAEARRLKLELTEGLLLQDVEDTIAKMVQLRGYGVGFSLDDFGTGYSSLAYLKRLPLQELKIDQSFVRDVLTDPNDAAIART
IVALGTSLGLQVTAEGVETEAQRVFLERNGCHAWQGYLLSPPLAVADYEALVLEHA----
>tr|C5T452|C5T452_ACIDE Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Acidovorax delafieldii 2AN GN=AcdelDRAFT_1682 PE=4 SV
---------------------------------------------------------------QRTRALKHADDARRQSEERFRAVFNQAAVGVAQIDTQ
GRFVRVNQKYGDIVGYTVEQMGQLS---FQAISHPADLVEDLAR-MERLKAITEYHMEKRYFHRDGHTLWVDLAVSAMWAPGAQPDYHIAVVQDISARKQ
MEASLRGNELRQRSLPVGVCLVQDDGRMTFRNARFVEICGYSQDDLPTSEDWWRAVYPDYRERTRAAWAAARSGTIASGEYTIRCKNGQQRVVEIAGVTM
D------DGHLVTMVDLSQRKADEEEIRYLAFYDPLTRLPNRRLLMDRLQQALATSARHQRSGALLLLDLDNFKTLNETRGHERGDLLLQQVAQRLRQCV
HEDDTVARPGGDEFVVVLEDLGDERSEEIGQKILAALREPYQLDAEVHHSSLSMGITIFSGMRETVDELLKRADLAMYQAKGAGRDTLRFYDPRMQAAVS
ARAAMELDMRVGLAQGQFELYYQPQIE--HGRITGAEALLRWRHPQQGFISPAQFIPMAEESGLILPLGEWVLQAACRRLAQWSQQPLAELDLAVNVSPR
QFHQGGFVPQVLAALAGSGADGHRLKLELTEGLLLEDVEDTIEKMGQLRGYGVGFSLDDFGTGYSSLAYLKRLPLDQLKIDQSFVRDVLTDPNDAAIART
VVALATSLGLRVIAEGVETEAQREFLARSHCHAWQGFLLSPPLAVAEFEALVRRIN----
>tr|J1EBG8|J1EBG8_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_05671 PE=4 SV=1
---------------------------------------------------------------QRTLALARADEARRESEDRFRALFNQAAVGVAQIDTR
GRFVRINQKYCDILGYSGEEMRALD---FQGVSQPEDLAIDLAQ-MERLKSISEYRMEKRYFHKNGSEVWVDLTVSPMWTPGTSPDFHMAVVQDISERKR
MENTLRGNEAHLRGLPMGLCLVQKDGTISFRNERFLQICGYSAQEVPNVDVWWERSYPDEREVMRNAWSEADDGIIAAAEYHFLCRDGVVRPVEVSGVRI
G------DDHLVTLQDLSQRKAAEDEIKNLAYYDPLTQLPNRRLLIDRLQQALATSARHQSHGALLLLDLDNFKTLNETQGHDKGDTLLMQVANRLRACV
HEDDTVARQGGDEFVVLLEDLGAERCEEAGQRILAVLREPYALGPEAHHSSLSMGVTLFSGVRETVDELLRRADLAMYQAKSAGRDTLRFYDPQMQAAVS
ARAAMELDMRVGLAQGQFELYYQAQID--QGRITGAEALLRWRHPRDGFVSPAQFIPLAEENGLILPLGEWVLQVACQRLARWAQQPLAGLGLAVNVSPR
QFHQSGFVAQVLAALAGSGADGSRLKLEMTEGLLLSDVEDTIAKMGQLKAYGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDVLTDPNDAAIART
VVALGTSLGLRVIAEGVETEAQREFLARNNCHAWQGYLLSPPLQVAEFEELVRRHN----
>tr|K0HZ89|K0HZ89_9BURK PAS/PAC and Chase sensor-containing diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. KKS102 GN=C380_12355 PE=4 SV=1
---------------------------------------------------------------QRTLALVRADEARRESEERFRALFNQATVGVAQVDSA
GQFVRVNQRYADILGYSPQELVGMT---FQSLTHPDDLAADLAH-VRRLQSVPEYRLEKRYIHKDGHEVWGDLTVSSMWASGSAPGYHIAVVQDITARKR
MEENLRANEQRLRSLPMGLCLVQDDGLISFRNARYVQICGYTQEEVPDTNTWWQRAYPDEREAIRQRLLD-TQGIIPLAEYTIRCADGKYKPVEISGIFV
E------GGRLITMQDLSERKAAEEEINQLAYYDPLTRLPNRRLLMDRLQQALATSARHHRSGALLMLDLDNFKTVNETRGHDRGDALLLQVAHRLRSCV
HEDDTVARQGGDEFVVVLEDLGDERAEDVGQRILGVLREPYQIDGDAHHSSLSMGVTIYSGTRETVDELLKRADLALYQAKNAGRDTLRFYDPQMQAVVS
ARATLELDMRVGLAQGQFELYYQPQID--HGRIIGAEALLRWRHPRDGFISPAHFIPLAEETGLILPLGEWVLQAACRRLAAWAQQPLATLSLAVNVSPR
QFHQTGFVAQVLAALAGAGVDGHQLKLEMTEGLLLQDVEDTIDKMGQLRGYGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDVLTDPNDAAIART
VVALGTSLGLRVIAEGVETEAQREFLERHHCHAWQGFLLSPPVAVAEFEALVRRTN----
>tr|A0A0D7K798|A0A0D7K798_9BURK Diguanylate cyclase OS=Acidovorax temperans GN=RP29_14210 PE=4 SV=1
---------------------------------------------------------------QRTIALVQADNARRQSEERFRALFNQAAVGVAQVDSH
GIIQRINQRYCDIIGYSPAELEGRS---LREISHPDDQPAGFAQ-MERLKAIAEFRIEKRYFHKNGREVWVDLTVTPMWSQGSNPDYHIAMVQDITARKQ
MEETLRGNEQRLLNLPVGLCLVQRDGRMSFRNERFVEICGYTEEDIPTAEQWWLKAYPDLRARHRTAWSSAHDGAIPAAEYSIQCRDGQQRTVEIAGVLV
G------NDHLLTMVDLSQRKAAEEEIRYLAFYDPLTRLPNRRLLMDRLQQALATSARHQRSGALLLLDLDNFKTLNETQGHDRGDTLLLQVSHRLRACV
HEDDTVARQGGDEFVVVLEDLGDERAEEAAQKILLALREPYTLDGETHHSSLSMGITIFSGMRETVDELLKRADLAMYQAKSAGRDTLRFYDPQMQAAVS
ERAALELDMRAGLAQGQFELYYQPQVD--NGRITGAEALLRWRHPRDGFVSPAQFIPLAEESGLILPIGEWALQAACERLALWAQRPLAGLTLAVNVSPR
QFHQSCFVPQVLAALARAGAEGSRLKLEMTEGLLLADVEDTIAKMSTLRSYGVGFSLDDFGTGYSSLAYLKRLPLTQLKIDQSFVRDVLTDPNDAAIART
VVALANSLGLDVIAEGVETEEQRAFLARNHCHSWQGYLLSKPIPAADFEQLVRDYN----
>tr|W8X4S1|W8X4S1_CASDE Uncharacterized protein OS=Castellaniella defragrans 65Phen GN=BN940_12761 PE=4 SV=1
---------------------------------------------------------------QRTRAYTEVHEALRRSEERFRAVFNQAAVGVSLTDVK
GRLVRVNQKYCDILGYARDELLRRD---FQQLTHPDDLALDLEQ-MQRVQAIREFRIEKRVLRKSGEPIWVDLTVSPIWQPGEAPDYHIAVIQDIDERRR
MQDALRERERRLRSLPVGVCLVRHDERIAFRNRQFVQIFGYTEQDVPDVQAWWARICPDVRERARQRWSRAREGVIAAGEYRILCGDGRHRTIEVAGVLL
G------DDYLLTLEDLTQRRAAEEEINYLAFYDSLTGLPNRRLLLDRLQQTLASAARHQRWGALLMLDLDHFKTLNETRGHDSGDLMLRQVAERLRTSL
PDSQTVARHGDDEFVVVLEDLGAEQAEEIGQRILALLSAPYLLGAEHYHATVSMGAAVFQGLEQGVDEHIKRADLAMYQAKAAGRNTLRFYDPLMQAAVH
RRATLELDMRIGLERGQFELFYQPQMD--RDRIIGCEALLRWHHPQDGFVSPAAFIPLAEETGLILPLGEWVLRAACEQLARWARDPFAHLSLAVNVSPR
QFHQPGFVDQTLAALAGSGADASRLELELTEGLLLRDVEDTIRKMVQLKGYGVGFSLDDFGTGYSSLAYLKRLPLDQLKIDQSFVRDVLTDPNDAAIART
IVALGISLGLRVIAEGVETEAQRAFLERHHCHAWQGYLLSRPLPAAEFEALVRQQA----
>tr|H0BW02|H0BW02_9BURK PAS/PAC and Chase sensor-containing diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. NO-1 GN=KYG_07825 PE=4 SV=1
---------------------------------------------------------------QRTLALARADEARQQSEERFHALFHQASVGVALLDTA
GRFLRVNQCFADILGYTPDEMLALS---SHSITHPADEATDARQ-LALLRKTPQYRVEQRLIHRQGHEVWADLTVSPMWMPGAAPDHHIAVVQDITSRKR
MEDHLRTNELRLRALPMGVCLVQDDGNISFRNRRYVEICGYTEAAVPDVEIWWQRAFPNERETMRALWEAAADGVVPAAEYAIWCADGIKRPVEISAVQQ
V------GGYLLTLQDLSERKAAEEEIKHLAYYDPLTSLPNRRLLMDRLQQALATSARHHRSGAVLLLDLDNFKTLNETRGHDSGDTLLQQVAHRLRSCV
HEDDTVARQGGDEFVVVLEDLGDERAEEVGQRILAALREPYIINGAAHHSSLSMGVTIFSDMRETVDELLKRADLALYQAKDAGRDTLRFYDPRMQAAVS
ARAALELDMRIGLAQGQFELYYQPQID--RGRITGAEALLRWRHPRDGFVSPAHFIPLAEETGLILPLGEWVLQAACARLAQWAAQPLAGLGLAVNVSPR
QFHQSGFVAQVLAALASSGAQGQKLKLEMTESLLLQDVEDTIDKMGQLKGYGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDVLTDPNDAAIART
VVALGTSLGLRVIAEGVETEAQREFLERHHCHAWQGYLLSPPVPVADFEALVRRTN----
>tr|F0QD61|F0QD61_ACIAP Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Acidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM
---------------------------------------------------------------R-H----------AALKDPFQTLFDQAAVGVAQVDTA
RRFVRANARFCQILGYEPQELLALT---VRDVTHQDDQAETEAV-IDRLAAQQEYRYEKRYRRKDGQMVWAELRLAPMRNDRRQPAQHIAVVQDISDRKQ
MEAAQRDSEARLRQLPVGVCLVARDGTLSFRNERFEQICRHADAVPSTVREWWEAVQPDRREQAMADWDAARDGTLPSREYAITCGDGSVRTVDMAGVLL
D------GACLITMVDLSQHKAAEEEIHYLAYYDPLTQLPNRRLLVDRLQQALAASVRRGRCGAVLMLDLDNFKTLNETQGHERGDMLLRQVAQRLRGCV
QNEDTVARHGGDEFVVVLEDLGQQRAEEMGQKILAAMRHPFMLEGEAHHTTLSMGVTVFQGARETVDELLQRTDLAMYQAKASGRNALRFYDPQMQASVA
ARAALETDLRDGLGRGEFELFYQPQVH--HGHIVGAEALLRWRHPARGFVSPGEFIPLAEETGLILPLGEWVLRAACERLAQWSRHPLSQISLSVNVSAR
QFHQGGFVGQVLAALAGTGAEGRRLKLEMTESLLQQDLEDTIQKMQQLRAYGVGFSLDDFGTGYSSLAYLKRLPLDELKIDQSFVRDVLTDPNDASIART
IVALGTSLGLRVIAEGVETEAQRVFLERNHCHAWQGYLLSRPVSADDFEHLVLSFP----
>tr|A9BZW1|A9BZW1_DELAS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Delftia acidovorans (strain DSM 14801 / SPH-1) GN=Daci_3589 PE=
---------------------------------------------------------------RHPSSWAQLSRSMRESDARFQALFEQAAVGVVQIDAA
GNVLHVNRRYCDITGHEAQQLCQRP---LLALVAAETVEGDRLL-LQELAARRALQIERQLRRSDGSLVWVELHISALGH--GPSLRLMALVQDISARRH
LQQMQRDGSRHLRMLPLGLAMLQEDGRFAYWNEEFMRLAGHGATAGMDGDGWWRNMCPDRRQRMQRRFEAARCGTLNSEEYQLIGSDGCARSVSIGGMLL
D------EGCLLILQDQSQRKTAEEEIRRLAFYDALTGLPNRRLLVDRLQQALASSRRRGRCGAVMLLDVDNFKAFNDSLGLELGDVLLRMIAERLAQSL
GREATLARHSGDDFVVLLEDLGKMKLEGEVQRMRSLLLQPLQLSGQSCHITLSIGASLFGEQELSADEVLRRAEMAMYQAKGMGRNTLQFFDPQLQAVLR
SRTAMEQEMREGLVRSQFVLYYQPQVA--NGRIVGAEGLLRWNHPREGLVPPSLFVSLAEETGLIQQLGEWVLGEACRQLAQWAAEPMACLMLAVNVSPR
QFHQARFVEQVLQALKEHGANPRLLKLELTESLLLADVDDTAAKMATLKAHGVGFSLDDFGTGYSSLAYLKRLPLDQLKIDRSFVRDVLSDPNDAAIART
IVALGTSLGLQVIAEGVETEAQRQFLEDQHCHAWQGYLLSPPVPVRSFEALVRQA-----
>tr|A0A096FKL7|A0A096FKL7_COMTE Diguanylate cyclase OS=Comamonas testosteroni GN=P353_10170 PE=4 SV=1
---------------------------------------------------------------SRWSWSRRLAQARQESDARFHAMCEQAAMGVLELDVA
RRVLKVNQHFCRLLGYEAQEIHRRS---VLELVMPEDQAHCAQL-LEGLDLFQHNAGEYCLRSKDGAPVWVELNAFLTGR--HESRRLQVLVQDISGRKR
LEQMERLGHQQLRNLPVGLVMEDLDGRLVYWNEEFLRLAGHGGKPSVSTQQWWERMFPDERERVIQRWEVARACMVSAQTLMLRGIDGLRRPVAVSAVLQ
A------EGCLMVLQDQSQRMAAEQEVRRLAFYDALTGLPNRRLLADRLQQALAVAQRKAHFGGVVLLDIDNFKAFNETYGLDQGDLLLQSMSQRIRGLL
PSGATIARQGGDDFVLLIEDLGSVRLEQQADQWLSRLREPIEIGGIPRSITVSMGLSLFGEAELTGEEVQRRAEMAMYQAKSQGRNVSCFFDPQLQSALQ
ERRTLEQDMRAGLQAGEFELFYQPQVE--MGKVIGAEGLLRWKHPEKGFVPPAHFIPLAEETGVILPLGDWVLQAACQQLAKWAKHPYAQLVLSVNVSPK
QFHQSGFVEQVLKALAEHGADARRLKLELTEGMLVSDVDDTIAKMMRLKSYGIGFSLDDFGTGYSSLSYLKRLPLDQLKIDRSFVRDVLTDPNDAAIART
IVALAKSLSLHVIAEGVETQAQCRFLEGIRCYAWQGYLMSPPVPVSEFESLVTNGN----
>tr|A0A014QF14|A0A014QF14_9BURK Diguanylate cyclase OS=Comamonas aquatica DA1877 GN=AX13_00820 PE=4 SV=1
---------------------------------------------------------------QRLRAQFQTHNLLRQQSDRLKALLHQSAIGVAEIEPG
GRYLSVNSRFSDVVGYDPKTLEMMD---LYQILHPEERPEFQRL-EGALAALAHFTVTQRMVRADGSEVWTEVWVSPVVDTGQSMGRQIVLLLDVTERQI
LQAQLHAREAYSSEMPVGLVVVGPSGNIEFVNHQFEVMTGWSQCDMADETTLWRLLCVDQHAALLQRLNAVVGVNMPAAEYLLRSKDGKELPIEVSGRFL
G------GRILLSFVDLSQRKAAEEEIRWLGFYDTVTQLPNRRLLLERLAEAVARCQRPGGKGALLLLDIDNFKSLNETLGHQHGDALLRLVATRLSNCI
AGQYTLARQGGDEFAVVLEDLPSLRAEQVGCAVLEALRTPFYLGAQDFHVTVSMGAVVFSGKSDTVEELLKRADLALYQAKSAGRDTLQFFDPSMQKAVS
ARVEMEKDMRLALERHEFDLYFQPQVQ--KDKVIGAEALLRWKHPVKGFISPSVFVPAAEESGLILPLGEWVLYAACRQLAQWAKDPMAGLTMSVNVSPR
QFYQPSFVEQVQQALRVTGAPPRMLELELTEGMLLADVEDTIRKMVQLKAMGVIFSLDDFGTGYSSLSYLKRLPLDKLKIDQSFVYEVLSSANDATIARS
IIALGNSLGLQVIAEGVETEAQREFLASSGCHYWQGFLFSQPKPIAEFETWTRAYG----
>tr|D8IWN5|D8IWN5_HERSS EAL domain containing protein OS=Herbaspirillum seropedicae (strain SmR1) GN=Hsero_2556 PE=4 SV=1
---------------------------------------------------------------SRVRAAQKMTAELRASEEQFRAIADCTVNWEVWWGLD
-------------TGYTVEEC-AMDD--F--IAHPED-EPRIRAE------QKREDVELRCV--DGSVFWL----ALSCAIH------RTSSRDITDRKQ
IEAELRISAVAFDS-REGMLITDANSKILRVNKAFTEITGYSAEEIVGKHPNLLRSDRHGPAFFQEMRESIRRFGKWQGEIWDRRKNGEVYPEWLTISAV
KNKDQQVTHYVSTHHDISDRKLAEERIRELAFFDALTRLPNRTLLLDRLKQAIALSLRTKTCAALLFIDLDHFKTLNDTIGHEKGDTLLKQVAQRLLANV
RENDTVARVGGDEFVVVLEGLNEQQTRAIGEKILTALGSTYQLDDVEYRTTASIGATVFLGRAASVDELMKQADLAMYKAKETGRNALRFFDPAMQTAVL
ERATLEAGLRKAIDGNQLLLHYQPQVVE-GGRVTGAEVLVRWQHPQRGMVPPGDFIPLAEETGLILSLGNWVLETACRQLATWAAQPMADLSIAVNVSAP
QLREPDFVQTVLDTIERTGANPRRLKLELTESLLVDNVEDIIQKMFALKAYGVEFSLDDFGTGYSSLSYLKRLPLNQLKIDQSFVRDVLIDPNDASIAKT
IVNLAQSLGLGVIAEGVETDAQRSFLADAGCHAYQGYFFCRPVTVEAFEKFAQEFD----
>tr|W0SG82|W0SG82_9RHOO PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_02152 PE=4
---------------------------------------------------------------NRDRAAGRMTASLRESEAQFRVLVEQAPDAIAVYDVD
GRFIEANSQAEQLNGKFASENLEMIDRVLRLVRLPAVGRRLVRGSTERRLAEGRCTF-----------CNPAGVRMLGWAER------------------
--------LTHFQK-PDGS--------------------AYPA---------------DECPIYKVL---ETGEDIWVEDEVFFRADGLGFPVRYGAHP-
LRRDGKIVGVVVTFTDITLRKAAETEIRNLAFYDPLTGLPNRRLMLDRLCQALTSSARRGRHGALMLFDLDDFKTLNDTLGHDVGDQFLVEVAARMESCI
REGDTVARLGGDEFVVILEDLDAAQAEIVAVKIQAALNQPYALHTRSYHCTSSIGITLFRDQSLSADELLKRADTAMYQAKAAGRNTLRFFDPEMQAAVA
ARAILNSDLRSAVRDRQFLLHYQPQVDG-AGLVTGVEALVRWQHPRRGMVPPGDFIPLAEDNGLILPLGRWVLETACQQLAVWGQRESSHLTMAVNVSGR
EFRQKNFVDDVLAILRDTGASSARLKLELTESLLLHDVEDMIAKMAALQGEGVSFSLDDFGTGYSSLSYLKRLPLGQLKIDQSFVQDVLDDNNDAAIVRT
IIALGQSLGLGVIAEGVETQGQREFLARQGCQAYQGFLFGRPGTADDLLKGCKADD----
>tr|J3HKH3|J3HKH3_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Herbaspirillum sp. YR522 GN=PMI40_04003 PE=4 SV=1
---------------------------------------------------------------SRVRAAQKMTSELRASEEQFRAIADCTVNWEVWWGLD
-------------TGYGVEEC-AMPD--F--IVHGDD-VNRIRAE------QKREDVEFRCV--DGSIFWL----ALSSAIT------RTSSRDITERKQ
VESELRISAVAFDS-REGMLITDANSRILRVNKAFTEITGYTAEEIIGKHPKMLRSDRHGPAFFQEMRESVRRFGKWQGEIWDRRKNGEVYPEWLTISAV
KNKDGNVTHFVSTHHDISDRKLAEERIRELAFFDALTRLPNRTLLLDRLKQAIALSARSKTCGALLFIDLDHFKTLNDTVGHEKGDLLLKQVAQRLASAV
RDNDTVARVGGDEFVVVLENLNEQQTKAVGEKILASLGETYQLEEVEYRTTASVGATIFQARQASVDELMKQADLAMYKAKETGRNALRFFDPAMQTVVL
ERAALEAGLRKAIEGGQLLLHYQAQVVE-GGRVIGAEVLVRWQHPQRGMVPPGDFIPLAEETGLILSLGNWVLETACTQLALWARQATEHLVIAVNVSAH
QFRQVDFVQTVLDAIDRTGANPRRLKLELTESLLVDNVEDIIQKMFALKAYGVEFSLDDFGIGYSSLSYLKRLPLNQLKIDQSFVRDVLIDPNDASIAKT
IVTLAQSLGLGVIAEGVETDAQRSFLADAGCHAYQGYFFCRPVAVEVFEKFAQDFD----
>tr|A0A069PSV5|A0A069PSV5_9BURK Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Burkholderia glathei GN=BG61_03665 PE=4 S
---------------------------------------------------------------GRSRAASTMTKELRENEEKFRAIADCTVNWEVWWGPD
-------------TGYTVDEC-AMQD--F--LVYPED-MARVAPV------LRGDDLEFRCV--DGSIVWF----SVSWGIT------RTSGRDITERKR
LEAELRIAAVAFDS-LEPMMVTDANSTILRVNSAFTECTGYAPDEVVGQTPRLLRSGRHDAAFFREMWDTIHRAGGWQGEIWDRRKNGEVYPKWLTISAV
RGEDGVVSHYVGTHHDITERKIAEERIKELAFFDALTRLPNRSLLLDRLKQAITVSARSGACGALLFIDLDHFKTLNDTLGHDKGDRLLQEVAQRLAASV
RESDTVARVGGDEFVVVLGSLGEQEIEAVGEKILAVLGNAYQLDDVEYRSSASIGATVFRGHQTSIDELLKQADLAMYKSKERGRNALCFFDPAMQTVVL
ERAALEADLRRAIEENQFLLYYQAQVDG-GERVTGAEALLRWQHPQRGIVPPADFIPVAEETGLILPIGSWVLETACAQLARWATRPMADLTIAVNVSAQ
QLREPDFAAKVLAVIGRTGATANRLKLELTESVLVDNVQDIIEKMSALKARGVVFSLDDFGIGYSSLSYLKRLPLDQLKIDQSFVHDVLDDPNDATIAKT
IVALAQSLGLGVIAEGVETEAQRDFLADAGCHAYQGYYFCRPLPIEGFENFVRTFE----
>tr|F9UDV9|F9UDV9_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_3061 PE=4 SV=1
---------------------------------------------------------------SKGDREDLVTTQIRARESELTRAQAVAKVGSWTMDPA
GRVQRSAETERILGPHEGQPCTTQA---LFGPVHPDDREITEQA-WQAARAP----FDICYRTLNGELSWLRARLEPAPTASNGRGCSVGTLQDITEHRA
ADAALRESEAFLNSLPVGIWFLNADGEIRFINEAGKRIWGGTRERFSEYKAWWLDSGKP---IEPADWAASR--TSLGEQIEIECFDGTRKIVLNSAVPL
RGTDGAVTGVVVVNQDITRDKAAEEEIRRLAFFDPLTRLPNRRLLLEHLAHAQAKSARSLQEGALLFIDLDNFKTLNDTYGHETGDLLLRQVAERLNGCV
REGDTVARLGGDEFVVMLEDLSTKHAERTAEKILAQLNPPYRIAEQSHHSTPSIGITLFCGHRESLEEVLKRADLAMYQAKGAGRNTLRFFNPEMHSVLA
RRATLEVDLRQGLLDGQFFLQYQPQVDD-NDKVTGAEALLRWRHPQRGLVSPGEFIPVAESSGLILPLGQWVLEAAARQLAVWARHSTSHLSLAVNISAR
QFRDPHFVEQVLRIIGQTGANPQRLKLEITESLLLDDIGDAVATMTALKSHGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDVLTDPNDAAIART
IVALAQTLGLGVIAEGVETQAQRSFLAEHGCHAFQGYLFGRPGGAEDLLAQSQSMA----
>tr|W0SFA1|W0SFA1_9RHOO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_02144 PE=4 SV=1
---------------------------------------------------------------TRDRAAHEMTGSLRESEARFRTLVEQAPDAIVVHDVD
GCFVDANAQAEKLNGKTAAQSVEMLDRALRLIRLPSADRRLIRGSTERLLARSREEMVGRTS----TGYWPSAEARMRWFALAGEPCTVNFMNDITERRM
AEQSQRIAAITFES-QEGMMITDAQKVMLRVNHAFSEITGYSSEEAVGRTPRLLSSGRHEAAFYDAMWESVEKNGTWRGEIWNRRKDGEIYPEWLSVTAV
KASDGTITHYVGTFSDITLRKAAEDEIRNLAFYDPLTQLPNRRLMLDRLRQALTSSARHGRHGALMLFDLDDFKTLNDTLGHDVGDQFLVEVGRRMESCI
REGDTVARLGGDEFVVILEDLDATQAESIAVKIQAALSRPYVLDTRSYHCTSSIGITLFRDQSVSVEELMKRADTAMYQAKAAGRNTMRFYDPAMQAVVA
VRAEMNADMRNAVREGQFLLHYQPQVDG-AGRVTGAEALVRWRHPRRGLVAPGEFIPLAEDNGLILPLGRWVLKAACNQLLEWAQRAMAHLTVAVNVSSR
QFRQRDFVEDVLSVIQETGANPHKLKLELTESLLLHDMEDIIAKMTALKAEGVSFSLDDFGTGYSSLSYLKRLPLGQLKIDQSFVRDVLTDSNDAAIART
IIALAKSLGMKVIAEGVETEGQREFLASEGCHAYQGYLFGRPGTAEALQESALQII----
>tr|A0A069IIU6|A0A069IIU6_9BURK Diguanylate phosphodiesterase OS=Cupriavidus sp. SK-3 GN=CF70_031285 PE=4 SV=1
---------------------------------------------------------------SRTRAADGMTRSLRESQAALAEAQRIARLGNWRIDLE
NWAD-FSGEMVRLRATLVARMQ---T--AIGNAHGLAGSRILRGTTQRKAA-------EQIV---G-AFWPTEAGRAMQL--RELGCWLA--KRM-----
-TWPQATAALM-----------------------------------PD-GPHWYASR--IARMPQHAWLGLTRGTVTLGELYDRRARDRYALAMGSA---
---------IASQTSHFLLRKEAEENLRFIANHDALTGLPNRLMFRDHLERRLAIPQSRQDGLSVLFVDLDQFKIVNDTMGHDAGDILLRGVADRLRAAL
PDVELIARLGGDEFVVLVEPKGD-VLSRTIRSMQAALAPGFAVNDKELRITASIGISSFPEDAADAQTLLKHADLAMFSAKQRGKNAHQFYAREMSESLR
RRVDMEAHLRRALERNEFELYYQPRISLTTNACTAVEALIRWHHPEFGLVLPGDFIPFAEESGAIVQIGAWVLREACRQNAQWLAQGLASMRVAVNLSAR
QFADKSLRLIILDALRQAGLPGNLLELELTESLVMRDAEQAARWLSKLKRTGVRLAIDDFGTGYSSLAYLSRFPIDVVKIDRTFIRHVPESRSDTQIASA
VIGLGHRLDLDVVAEGVENAQQLNFLRSEGCDEVQGYYFSQPLPAEDITAFLVSHT----
>tr|G0ERE9|G0ERE9_CUPNN CHASE, PAS, GGDEF and EAL domain containing signal transduction protein OS=Cupriavidus necator (strain ATCC 43291 / DSM 13513 /
---------------------------------------------------------------SRARAADQMTHSLRDSQAALAEAQQIARLGDWRIDLD
DIAH-FSREMARLRAVLQERMR---V--AIGHAHGAADSAVLRGTSQRKSA-------EEIV---G-AFWPGDDSQGLKL--KVLQPWFA--ERP-----
-AGPAGA--AV-----------------------------------LQ-APQWYASR--MARHSQARWLDRTRGHVTLGVLYSKRSPDTHALAMAGG---
---------IANQTGHFLLRRQAEENLRFLANHDALTGLPNRLMFKAEFEQALTRARASDQALHVIFVDLDEFKVVNDTIGHNAGDIVLREMADRLRGSL
EEVELITRFGGDEFVVLLDPKGD-LLERTIARIQAALAPGFVVNESELRMTASIGISSFPEDGSDWQTLLKHADLAMYGAKQLGKNGYQFYCRGMSASLQ
RRIDMETHLHRALEQNEFILYYQPRIALASGACTAVEALIRWRHPELGLVMPGDFIPFAEQSGAIVEIGAWALREACRQNAAWRAQGLPPVRVSVNLSAR
QFADKSLRLTIIDALRQAALPGNLLELELTESMIMRDAEQASSWLSRLKRTGVRLAIDDFGTGYSSLAYLSRFPIDTVKIDRSFVRYVPESRSDTQITSA
VIGLGHRLGLEVVAEGVENEVQLEFLRREGCDEVQGYYFSHPLPPAKITAFLASRM----
>tr|Q46NB5|Q46NB5_CUPPJ Periplasmic sensor diguanylate cyclase/phosphodiesterase OS=Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) GN=Reut_C602
---------------------------------------------------------------SRARAAEQMTYNLRESQAALSEAQQIARLGDWRIDLE
SSAH-FSREMARLRIVLREKMQ---A--AIGHAHGAQDSAVLRGTSQRKSA-------EDIV---G-AFWPSEDTHGLKL--KALEPWLA--EHP-----
-ECLARE--AY-----------------------------------SH-VPQWYANR--LARHGQARWLVRARGPVTLGVLYARRSPDAHALTMASG---
---------IANQTGHYLLRRQAEEDLRFIANHDALTGLPNRLMFKAEFEKALTRARNSEQALHVIFVDLDEFKVVNDTIGHNAGDAVLREMADRLRESL
PDVELISRFGGDEFIVLLDPKGD-ILGRTIARIQAALELAFIVNDTPIHMTASIGISSFPEDGNDWQTLLKHADLAMYGAKQIGRNGYQFYCQRMSASLQ
RRIDMESHLRRAIEQQEFILYYQPRIVLDSGACTAVEALIRWRHPDLGLIMPADFIPFAEQSGIIVDIGAWALREACRQNAAWVAQGLPPVRVAVNLSAR
QFADKSLRLTIIDALRQARLPGNLLELELTESMVMHDAERASRWLSRLKRIGVRLAIDDFGTGYSSLAYLSRFPIDTVKIDRSFVRYIPESRSDTQITSA
VIGLGHRLGLEVVAEGVENEAQLEFLRSEGCDEVQGYYFSHPLPPAKITAFLASRM----
>tr|C5CTK8|C5CTK8_VARPS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Variovorax paradoxus (strain S110) GN=Vapar_3579 PE=4 SV=1
---------------------------------------------------------------ARSRAANEMTRHLRTSERQLEEAQHLASLGSWILDPE
GALQ-CSEEARRIRPAVEQQIA---Q--AIAQSAEEDGKTMVRGTTRPRKD-------TQAL---G-ALWSVGEDGVVRC----AAAWHA--DHI-----
-PPAVRQFASD------------------------SRSFEYRADEGSL-GRAWKTGGILPGHFARDAMARAVVT-DSITALLNPYAIDAQTQESLRV---
---------IALQIAQYKQRKQAERSLRFMASHDGLTGLFNRAALQHELARAIKRSNRHQKQFAVIFVDLDRFKHINDTLGHGVGDEMIKICGERLTALL
READVVARFGGDEFVLLLENLSS-DAAGLAEKVLACCAEPFFLAGRELHVSASVGVSIYPDNGADAEALLKNADTAMYRAKERGRNTFRFYAAKMNAQNT
EQLMLESALRHALERGELEMHYQPKMDLQTQRIVGVEALMRWHHPILGMIPPVQFIPIAEELGLIVSLGKWALERACADSRSWQKYGLPKVLMSVNLSPR
QFESRTLIADIQAVLEASGLEPSLLELEITEGAVMANPEHAAKLLRAIRDMGVGLAIDDFGTGYSSLSYLKHFPLSTVKIDRSFINDLSQDADARALIDG
IITLAHGLRMKVVAEGIETTAQLDYLRSHGCDEAQGYWLCKPVPADEVRNFMARHL----
>tr|J2JTC0|J2JTC0_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Variovorax sp. CF313 GN=PMI12_04483 PE=4 SV=1
---------------------------------------------------------------SRSRAATEMTSHLRTSERQLEDAQHLASLGSWILDPE
GALQ-CSEEARRIRSEVERQIA---Q--AIAQSAEEDGKTLVRGTTRRRKD-------TQAL---G-MLWRVGDDGLVRC----AAAWHA--DS------
-GPAVRQFVSD------------------------SRSLEYRPGEGSL-GRAWGTGGVRPGDFVHDAMAGAGTT-GVTTALFNPYVDDAETLESLRV---
---------IALQIAQYEQRKLAERNLRFMASHDELTGLFNRAALQHELDRAIKRSNRHQKQFAVMFVDLDRFKHINDTLGHGVGDEMIKTCGERLTALL
REDDVVARFGGDEFVLLLENLSS-DAAVLAEKVLACCAEPFVIEGRELHVSASVGVSIYPDNGGDVEALLKNADTAMYRAKERGRNTFRFYAAKMNAQST
ERLILESALRHAVERGELEMHYQPKMNLQTRRIVGVEALMRWHHPVLGMIPPVQFIPIAEEIGLIVSMGRWALERACADARAWRNYGLPDVLMSVNLSPR
QFESQTLAADIRGILEASGLEPALLELEITEGAVMENPEYAANLLRTIRDMGVGLAIDDFGTGYSSLSYLKLFPLSTVKIDRSFINDLSQDADARALIDG
IITLAHGLRMKVVAEGVETEAQLDYLRIRGCDEVQGYWLCKPVPADEARNFMARHL----
>tr|H8GLC0|H8GLC0_METAL Diguanylate cyclase (GGDEF) domain-containing protein OS=Methylomicrobium album BG8 GN=Metal_0256 PE=4 SV=1
---------------------------------------------------------------GRERAARDMTRELRESESHTRRLNRSLKLLS---D-C
MALVRAEEEHQLL-----HDE-----------------AKTVRP-------VAQAGFEMGYL--NNIVTWADTERGRGPT-G----AIRTGLTDINQ---
---------NYL-----------DNPRMAPWREAAL-QCGYRSPLIGNKG--------------------VLALTLYSQESFAFSAEEVQLL--------
EELAGDLAYGIETLRTRAEHQRAEEQLSFMAYHDPLTQLPNRRLLHARFDQEIVPAGRNAAQVALLYLGLDNFKQVNDTLGHSQGDRLLVLVAERLNRCV
RDTGMLGRNGGDQFVVLMANVR--CIDAVARSVIEAFAEPFAVENNLINATFSIGISVFPNDGADFDALFKKADTAMFYAKDSGRNTYCFYTKQMNSDGM
EQMWLQGQLSGGLKNRELRLHYQPQIDLSRGCIAGVEALLRWEHPERGMISPARFIPLAERSGLIIPIGEWVLNEACRQAKAWFDEG-HPLVVAVNLSVL
QFKRGNLLETVTHALEDSGLPPSLLELELTESILLQDQEAAIKTIAELKERGVKLSIDDFGTGYSSLSYLKRLAVDKLKIDQSFVRDLASNPEDAAIARA
IILLGHTLQLTVIAEGVETKAQLDFLKNEGCDEVQGFYFSRPVPAAEVAGWFARDV----
>tr|B8GSM8|B8GSM8_THISH Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) GN=T
---------------------------------------------------------------TQARAADQLEARLSDSEYRWRFALEGAGDGVWDWNLE
NTV-YFSRRWKSMLDSTLAELK---G-YLVVSRDGQGRPLRMIGTSGQKALDDYDAVVESIQFPDGTVRWLYGDSLPH-R--DGSTLWYGFITDITERKE
AEAALRKAHSETQRVSSFIYMKDTQSRYTYANRATLELFGTNDHDLP---------GSDDFRFFSDSTAHRLDRHVFLGEIEDPGGHRRVYLEIKTPIYD
ETERDEVIGLLGISTDITAIKEHERQLEHIAHFDALTNLPNRVLLADRLHQAMAQAVRRGHHLAVAYLDLDGFKAINDRYGHAVGDKLLMAVAQQMHEVL
REEDTLSRLGGDEFVAVLLDLAD-ACVPLLTRLLAAAARPVSIEGRELRISASLGVTFYPQEQIEAEQLLRQADQAMYQAKLAGKGRYHVFDAELDRSVR
THHESLERIRSAFENDEFVLHYQPKVNMRSGAVIGAEALIRWQHPDKGLLPPGDFLPVIEDHPLAIELGEWVITRALQQMASWQTAG-LVLPVSVNIGAS
QLRQDTFVSRLRTLLDGFPISPGSLELEILETSALGDLALVTRLLDQCRAIGVNIALDDFGTGYSSLTYLKRLPAGVVKVDQSFIRDILMDPEDLAILDG
VLGLAGAFNRQVIAEGVETVEHGDMLLRIGCELAQGYGIARPMPAEALHDWVKRWR----
>tr|I3Y6Y1|I3Y6Y1_THIV6 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiocystis violascens (strain ATCC 17096 / DSM 198 / 
---------------------------------------------------------------TRA-NARNLEQLLKESEFRWRFALEGAGDGVMDWSVP
GKVF-YSRRWKEMQAHALATIQ---A-YFVVSFDDAGKPLRMIGTTAWKRSYDRDEVLG--------GREF------------YESMWRTLIEDG-----
---------------------------------------------------------------------------HWSGEIWNRRKNGEVYAEMQTISAV
RDAQGSPQHYVALFSDITALKEHQRQLEHIAHYDALTSLPNRVLLSCRLLQAMTQTKRRAQRLAVAYLDLDGFKAINDSHGHEAGDQLLMIVAGRMKQSL
REGDTLARLGGDEFVAVLVDLGD-GSVPMLTRLLMAAAQPVPVEGLVLRVSASIGVTFYPQEEVDADQLLRQADQAMYQAKLSGKNRYCFFDAEQDQSIR
GHHANLEQIRRALTVSEFILHYQPKVNMRTGAVIGVEALIRWQHPERGLLAPALFLPVIEDHPLAIDLGEWVIETALTQMDVWRAGG-LNLPVSVNIGAR
QLRQTNFVECLRARLLAHPIVPNGLGLEVLETSAQEDLNRVSTVIDACREIGVLCALDDFGTGYSSLTYLKRLAVSLLKIDQSFVRDMLDDPEDLAIVES
VLGLAAAFRHQALAEGVESLEQGEILLQLGCELAQGYGIARPMPGEAVPDWVRSWH----
>tr|H2FTU6|H2FTU6_OCESG Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Oceanimonas sp. (strain GK1) GN=GU3_08190 PE=4 SV=1
---------------------------------------------------------------SRARAAEQLEHR-------------------------
---------------------------------------------------DDVDEVAEAILGPDNQPRWLLGDALPR-R--DGATSWFGVITDITGRKQ
AEQALKAAHSQSRHVSSFIYMKDTRFRYIYANRAALEQFGCNSITLK---------GCMDEQFFARETAQVLDNRVLAGEVEGKDGRRTVFLDVKTPIFD
DPEHREIVGLLGIRTDITLLKDSEQQLRQLAHFDPLTRLHNRVLLSDRLRQAMAQARRHQQAVAVVYLDLDGFKAINDTHGHAAGDKLLVAVAGRMKEVI
REGDTLARVGGDEFVAILLDLAD-HCTPLLDRLLQAAARPVNLDGLRLQVSASLGVTFYPQEELDPDQLLRQADQSMYQAKLAGKNRYHLFDTERDRSVR
THHESLEHIRHALHNGEFVLYYQPKVNMRTGQVIGAEALIRWQHPQQGLLPPSHFLPAIEEHALAIELGNWVIDAALQQIREWQAQG-LKLVVSVNLSAR
QLRQEAFVAQLTQLLGHYPIDPAWLELEILETSALGDLAQISERLCQCRKLGLGISLDDFGTGYSSLTYLKQLPAGIVKVDQSFVRDILEDPEDLTILDG
VLSLARAFGRTVIAEGVETVEHGNMLLRIGCELAQGYGIARPMPAAELPGWVAGWK----
>tr|U7G694|U7G694_9ALTE Uncharacterized protein OS=Marinobacter sp. ES-1 GN=Q666_10460 PE=4 SV=1
---------------------------------------------------------------TQHKAAERL----------------------------
---------------------------------------------------DDAERVRDSIMHPDGSVHWVLGNALPH-K--DGSVIWYGSLTRITERKE
AELRLRQALTEASRMDTLVFMKDMDLRYTYANSATLTRFGLSRNELL---------GTHGEPVFDNMSIERIDERVLRGAVENIRGERAVLLQIKTPIYE
DGGSEHIIGLIGTSTDITKAKQQAQEIERLAHYDALTGLPNRTLLADRLNQAMAMVDRRQSSLAVVYLDLDGFKAVNDSHGHSAGDQVLITVASRMRHEL
REEDTLSRLGGDEFVAVLMDMSS-DFETHLERLLKAVSRPILLKDKAVTVGASLGVTFYPQDISGGDQLIRQADLAMYQAKLSGKSRFHLFDTEQDRSLR
SQHETIERMHQALKNNELCLYYQPKVNMRTSEVIGAEALLRWQHPERGLLAPGAFIGLVENTPLMLDIGRWVMDSALAKMNEWLEQG-VRVPLSINISAI
ELRDPNFPEHLAAALKSWPLDPAMLELEVLETAALGDLGQIARVLDSCRQLGVSIAIDDFGTGYSSLTYFKRLPAKVVKIDQSFVMGILRDPADLAILDG
IVRLADALDRQLIAEGVETFEHAEMLLRIGCDLAQGYGVARPMPADDFLPWRARWR----
>tr|F9U7L2|F9U7L2_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_1088 PE=4 SV=1
---------------------------------------------------------------TRA-SAHNLEQLLEESRQALADVLDNAS--IHIWAFN
IRYSYLNKAFYDFLASAGAVWQ---A-AYVPIFHRNGEFFHFQGFTDRKQAYAREDVLG--------GREF------------YASMWRTLIENG-----
---------------------------------------------------------------------------RWSGEIWNRRKNGEVYAEMQTISAV
RDALGSPQHYVALFSDITALKEHQRQLEHIAHYDALTSLPNRVLLSFRLLQAMAQTKRRAQRLAVAYLDLDGFKAINDTHGHETGDQLLMIVAGRMKQCL
REGDTLARLGGDEFVAVLVDLGD-GSVPMLTRLLMAASQPVPVDGLSLQVSASIGVTFYPQAEVDADQLLRQADQAMYRAKLSGKNRYSVFDAAEEQSIR
GHHANLERLSQALAEHEFVLHYQPKVNMRTGAVIGVEALIRWQHPERGLLAPALFLPAIENHPLAVEVGEWVIETALTQMDDWLTGG-LELPISVNIGAR
QLRQADFAACLNARLLAHPRAPNGLELELLETSAQDDLVSVSKVIDACREIGVHCAMDDFGTGYSSLTCLKRLAVSLLKVDQGFVRDMLDDPGDLAIVES
VLGLAAAFHHEVLAEGVESLEHGEILLQLGCELAQGYVIARPMPGESIPPWVRAWR----
>tr|A0A090IAY9|A0A090IAY9_9GAMM Putative membrane associated signaling protein, GGDEF family protein OS=Moritella viscosa GN=MVIS_0909 PE=4 SV=1
---------------------------------------------------------------IKNSQKNIVTKELGDNLKRLNLALTSAGQVWFELNVQ
GEIL-FGGQYEQLLESVSNKYQAL----IFTESDAHKKPLWCTGVSQRKKIGDGVGSCGTAAAKAQLACWSEPIIGSNNQ--KLLEFAVQLSVIAIERNL
SDKKIKLSSRVFSDTNEGLMITDTTGKIIDINPAFTRTTGYSRHEVLGQTPNILSSDKQSPAFFIEMWQNLIEQGHWYGEVWNKKKNGELFAARLSISSL
TNDDDDTLHYVGLFSDITEIKQQ-QKLELMAHYDMLTKLPNRSLLADRFRSSIAHSKRTDTMFGVCFLDLDNFKPVNDSYGHDIGDQLLIAVAQRLKTNI
RDEDTASRQGGDEFVLLLGDIES-HCNEILQRINYFLAQPYIIAGHTFNISVSIGVTLYPGDDADLDTLLRHADYSMYQAKLAGKNRFHLFNPEHDQLTI
KKHLQLDEIQQALSNNEFVLYYQPKINMKSGEVFGAEALIRWLHPEKGLIPPLEFLPIIEGSELENRIGDWVINEALKQIVAWQNQR-IFIEVSVNIASY
HLLSSAFLTQLENALVSHPLNSKYLQLEILESSALGDLNTIRNILNTCQVLGVNIALDDFGTGYSSLTHLKNLPANTIKIDQYFVKNMLDDPDDYAIING
VLALADSFNREVIAEGVETTEHGLMLLNMGCYAAQGYGIARPMPASEFPNWLHNYT----
>tr|H8Z6P1|H8Z6P1_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiorhodovibrio sp. 970 GN=Thi970DRAFT_04413 PE=4 SV=
---------------------------------------------------------------TQAQ-VALANQHLAEQERLLLWAQRTAQLGSWNFDPS
GQVS-WSEGMFPIWDAFDQAVN---R-A-TPHLDAQGQVVRLSGTTEREQEEDFARLTTAMNRRDGSTRQCFARGYPETR--HGVTHVYGTFEDITERKQ
AEQKLRLAAKVFAH----IIITDAENRIIDTNPAFTTITGYEQASVLGKDPNILASGRQDEAFYREMWDAI-HQGSWRGEVWNRRQDGQLYAELLSISVV
HDAADAVQNYIGVFSDISEIKAHEGELDHLANYDALTELPNRRLLSDRLEQALAGTRRSERFIAVCYLDLDNFKPINDQHGHEVGDEVLIGIADRLRKLM
RAQDTVARLGGDEFVLLFTDLAR-DCHLLLERVLAAATTPILSHGVAHRVSASIGVVLSPPDVDSADTLLRHADQAMYIAKEAGGNRYHLHDAEQNRLIQ
EQRLKRHHLEQALDGQGFVLYYQPKVNMVSREVIGVEALIRWPHPDEGLLLPGAFLPLVEGSDLEIAIGEWVIAAALTQLATWQRLG-LKLPVSVNISNG
HLLQPSFAQRLEQLLAEHGCDPGCLELEVLETSALSDIERTSQTLTACRALGVRFALDDFGSGYASLAYFRRLPIDVLKINQSFVQDMLGDAEDREIVES
VVRLAHAFDRLVIAEGVETPEQEALLTLLGCRMGQGFGIARPMPAEAIPDWVSNWS----
>tr|M5DH75|M5DH75_9PROT Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Nitrosospira sp. APG3 GN=EBAPG3_16800 PE=
---------------------------------------------------------------NREKIRQANTLELSNSKQRTQRILESITDAFFTLDRE
WRFTYLNKEAETLVGSTFEREF---HRALEVHAYPS--EEGLAVYTERKRS--GIDLEGRCMRADGTIYPVEQCAILQTLI-GETTGTVVIFSDITQRKD
AELARREADARIREAKDAIIVRSINHHIQFWNQGAERLYGWTLEEVNGKSIENILY--DDSTAFHEAMQLVLRDDEWRGELTQRRKDGSTLITEGHWTLV
RDDKDQPQSILTINTDITQRKAAEDEIHHLAFYDSLTQLPNRQLLLDRLQQALAASARSHNMGALLFIDLDNFKTLNDTLGHDTGDLLLRQVAPRLVSCV
RENDTVARLGGDEFVVVLGDLGSHQIKMICERILAAFTEPFHLGAYEHHSTPSIGVALFNDQPTTLDELLKRADLAMYQAKASGRNAMCFFDPDMQEVVN
VRVVLESDLRRGLEKKEFLLHYQPQVDG-NGRVTGAEALVRWQHSRRGLLPPAEFIPHAEESGLIYPLGHWVLETACSQLSAWSARPTARLNMAINVSPR
QFRHPDFVDQVLSALDHTGADPQKLKLELTENLLVHNVEDIIAKMATLKTRGVGFALDDFGTGYSSLYYLKRLPLGWLKIDQSFIRELLTDPHDATIVRA
ILVLAKSMGLSVIAEGVETNAQKSFLAQHGCDAYQGYLFSRPLTFEQFEVFYSRKD----
>tr|F9ZXY2|F9ZXY2_METMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Methylomonas methanica (strain MC09) GN=Metme_0111 PE
---------------------------------------------------------------ISGRTETVITQDLQKANCELQAAERHIRE--------
-----------------SEAYLTI----L------------PAGL------AVFAGESRSLL-----TCWLESTAT------GHITALLWMARDITERKT
ADERLKLAARVFGEAHEGILITDEAANIIDVNPTFCDITGYNRDEVIGKKPSLLKSGRQDPAFYRDMWQAIKSDLHWQGEVWNRKKNGELYAELLSISAL
CDDQGRIIYYIGLFSDITQIKHQQQMLELMAHYDPLTRLPNRTLFSDRLSQAIARSKRDKLLLAVCFLDLDGFKPINDQLGHGAGDQVLIEVANRIKQSL
REEDTVSRHGGDEFALLLTGLHS-EISQTLTRIHQAIAETYVINGQAVQVGASTGVSIFPLDDADADTLIRHADQAMYQAKLTGKNRFQLFDASQDQLMF
DHHNQLHELEAAFADQQFCLYYQPKISLKTGRVTGVEALIRWQHPEQGMMSPLSFLPTLAATELEINLGNWVIEQAWRQLFLWHRQG-IKIEISVNISAY
HLLWPGFVSHLETILAKHPIASHYLQLEILESTALDDLSAVNRTVKTCHALGIGAALDDFGTGYSSLTHLRHLPVDTVKIDRSFVRDMLDDPDDFAIVES
VISLSQAFGNQVVAEGVETQEQGLALLLLNCYVAQGFAIAKPMPASEIVNWINFYQ----
>tr|A0A0A6TQI1|A0A0A6TQI1_9GAMM Diguanylate cyclase OS=Methylomonas denitrificans GN=JT25_06655 PE=4 SV=1
---------------------------------------------------------------ISGRTQALVTQALADAVAELEASANIAKE--------
-----------------SELKLTI----V------------RAGL------RVFAGASGTLE-----QRWLDTHAV------GNITALLGLTRDITERKQ
AEEHLKLAARVFSEAHEGILITDAAAIIIDVNPTFCEITGYSRAEVIGRNPSMLQSGKYGSDFYRDMWQALREAQHWQGELWNRKKNGELYAEWLTVSAL
CDADGNVTHYIGLFSDVTHAKQQQQLLELFAHYDPLTRLPNRILFADRLNQAIAHSKREKSLLAICFLDLDGFKPVNDQFGHDVGDRVLVEVAERIKNAI
REEDSVSRHGGDEFALLLGDLES-QCEQAILRIHRAIAQPYVIDDQPISVGASSGFTLYPLDDADADTLLRHADHAMYQAKLAGKNRCQLFDATHDQQIM
HRHQQLRDIEAAFLNNELCMYYQPKVDIKTGQVKGVEALIRWQHPQRGMVPPLEFLPVIASTDLEIRIGNWVIAQACEQLAGWHEQG-LPLEVSVNISSY
HLLWPGIGAYIETTLHSHPIDARYLQLEILESTALDDLSAVNRIIKSCRQLGISVALDDFGTGYSSLTHLRHLSVDTVKIDQTFVRDMLDDPDDYAIIES
VIDLSQAFNRGVVAEGVESQEQGIVLLLLGCHLLQGYAIARPMPAAAIADWVTDYR----
>tr|A0A061JLZ9|A0A061JLZ9_PSEST Uncharacterized protein OS=Pseudomonas stutzeri KOS6 GN=B597_019315 PE=4 SV=1
--------------------------------------------------------------------------------ALLRTIIENSPDAMTLKDSK
GVYLACNAAAEQLLGLPSEQILGKT---DRELFQDKDYDLAHANDQQAQRTGHRQRYEAAVTTPDGATLELEVLKVLVHDIDGASVGVLTTARDITERRR
DERELRIAAVAFES-HDGQIITNGNGVIERVNAAFTRITGFSADEVIGKTSECLRSGMHSQAFYDDITAALQRDRHWHGEVINQHRDGHLYSARLSISAV
SDVQGRTMRYIGNLQDITAEKEALKQAEHLKLFDALTDLPNRMLMEDRIRHALDNSCELREYGAIMMLDLDFFRQVNDSLGHACGDLVLIEVTRRVRSVI
REGDTLCRFSGDSFVLLAENLGLRHAQQLAEAIRQAVKNPMIANGHRLICTVSVGVTLYFDHETNSDALLRQAELAMYKSKSRGRNMCYFFEDAMQIEID
ERRKLKEELGEAIDQQQFVLHYQIQVDAQGHPI-GAEALLRWNHPQKGIVSPAKFIPLAEETGLIEPIGRWALATACRQLADWAQHTLRHLTIAVNVSPR
QFKSERFVKDILKEVRQSGVSANQLKLEVTESLAIDDFEDSIAKLDALRTLGFQIALDDFGTGNSSLNYLTKLPLTQLKIDKSFVDNLPASHRDAMVVQT
IIAMSRGLELHVIAEGVENEAQRDFLATLGCEAFQGYLFGRPLPGNEFMEAALRG-----
>tr|C7RJ77|C7RJ77_ACCPU Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Accumulibacter phosphatis (strain UW-1) GN=CAP2UW1_3428
--------------------------------------------------------------------------------RLLTD--VLPAAAIVATDPQ
GLITVFNPGAEAIFGYAAHEVVGKV---TPTLWHDAEEAAAAVALSRARCSGQVDERETAGVRKDGRRITIRLA-VTVMDAQGALAGYLGTIVDITAQKQ
AAAQLNLAAKVFEQGGEGIAITDAACNIVMINQAFTRITGYSEVEVLGRNPSLLASGRHDQAFYQSMWESIESLGHWQGEIWNRRKDGSVYPEWLLISRV
D-GDGAPTHYIGTFIDITQHKEAEASIQRLAHFDALTGLPNRSLLEERVRHDLARAHRGREALALMFVDLDRFKNVNDSLGHRVGDALLIQVAERLRRAV
RDEDTVSRLGGDEFIVVLPS-TDDGAAHVAAKLLEVMAPAYRIEQHELTCSLSAGIAMYPADGESFEALSMSADTAMYRAKQSGRNAYCFFTAEMQERSA
RNLQIENDLRRALENGELRLHYQPQFTLADRRLVGAEALLRWQHPQLGMVSPVEFIPIAEECGLILPIGEWVLRAAVSQLRVWQQEGLPPMTVAVNLSAV
QFRQASLTDVVSRILDAEGLAAQFLELELTESVAMDNPLAAIATMDKLRALGVRMSIDDFGTGYSSMSYLKRFRVHKLKIDRSFVADLAADPEDEAIVTA
TISLARDLGLQTIAEGVESEAQLAFLRAKGCDEAQGYLFSRPLAPAQFAAFVRAH-----
>tr|A0A011NVP0|A0A011NVP0_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-12 GN=gmr_1 PE=4 SV=1
--------------------------------------------------------------------------------RRVSE--FLDPAAIVATDPE
GLITLFNPGAEVIFGYRADEVLGRA---TPMLWHDPDERAAAVALRRARVSGEADEREMRCIRKDGRRISVRLA-VTVMDGGGQLKGYLGTVVDISEQKR
AAAELNLAAQVFERGGEGIAITDAACRMVMVNRAFSRITGYAAAEVLGRNPSMLASGRHDAAFFRGMWQAIETDGSWQGEIWNRRKDGSVYPEWLSISRV
E-SEGVTTHYLGSFIDLTRHKEAEASIQRLAHYDALTGLPNRSLLAERVRHDLARAHRAREPLALMFLDLDRFKNVNDSLGHQVGDELLVQVARRLHGAV
RDDDTVARLGGDEFIIVLAN-TDDGAAHVAAKLLDVTTPAYRVGPHELSCTMSAGIAMYPTDGDSFESLSMCADTAMYRAKQVGRNAYCFFTVEMQARSA
RTLLIENELRRAVELGQLSLHFQPQFALADGRLLGAEALLRWQHPELGMVSPAEFIPIAEDCGLILSIGEWALRMAVRQMRIWHASGLPGLGVAVNLSAV
QFRQAGLPALVARILDSEGLPAHFLELELTESVAMDQPLAAITTMDSLRALGVRMSIDDFGTGYSSMSYLKRFPAHKLKIDRSFVADLASDPDDEAIVAA
TISLAHNLGLQTIAEGVESEAQLAFLRAKGCDQAQGYLFSQPLPAAQFAAWATQP-----
>tr|D5CRV6|D5CRV6_SIDLE Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Sideroxydans lithotrophicus (strain ES-1) GN=Slit_1455 
--------------------------------------------------------------------------------KKIGD--VLPPDAIVV----
GTLTLYAEEK--------------------NAFDEPA-----RNLLLERFDAE------------------------------------------TERKK
MSETLLKLSLAVEQSPNSIVITDLDANIEYANSNFTKVTGYSLDEVLGKNPRFMQSGKTPKATYEDMWAHLTRGEPWKGELFNRRKDGTEYIESVLISPV
SQVDGRVMNYLAIKEDITEKRLTEERIEKLEHFDHLTGLPNRTQLNERFKYALSLAQRSGEQMTVMFLDLDHFKDINDTLGHSIGDQLLMDVAKRLKETL
RDEDTVSRQGGDEFILILPG-TDNGAAHVAAKLMEAVSQAFQFEQHELVATCSIGIAIYPHDGENFETLSKNADTAMYRVKHDGRNGFCFFTSEMQAHSA
RTLQLGNALRHALTRGQLHLHYQPQISTQDGHVVGAEALLRWQHPELGSISPAEFIPIAEDNGQIIPIGEWVLRTAIKQLKDWMDSGLPPMIMAVNLSAA
QFRQSNLMELVTSILDESKVPHRYLELELTEAVAMDDPQLAIGVMDKLHTGGIKMSIDDFGTGYSSLSYLKRFKVYKLKIDQSFVHDITDDPDDKAIVAA
IINMASSLGMQTIAEGVETAGQLSFLRLQGCNEVQGYYFSKPLPAEQFVSYLQKQ-----
>tr|C6XBJ6|C6XBJ6_METGS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylovorus glucosetrophus (strain SIP3-4) GN=Msip34_2729 PE=4
--------------------------------------------------------------------------------PRWAEMLGYTPDEVAMFDRD
MRYLACSNQWQEEFGHQQGSLLGLN---HYDVH--PDIEKWRQAHQRALAGERLEEEEDLWIRADGQHLWTRWM-ITPWDDSQTIQGIIISSENISARKQ
AEEELRLAHTVFEHSSEAMLVTDADNNIITINPAFSEMTGYSLEEVIGKNPKILSSGRQGKEFYQELWNTLETSGEWRGEIWNRRKSGEEYAEWLAINNI
YSEDGKLFRRVALFSDITEKKRADALIWNQANYDLLTQLPNRRLFSDRLQQE-KKSQHDHSQFALLFIDLDRFKEVNDTLGHSHGDYLLIEASHRIQRHL
KETDTVGRLGGDEFTVIIANLPDSVMTLIAQRVLDALAAPYDLEGEIVYLSASIGITVFPEDATTSAELLKNADQAMYEAKKNGRNRFSFFTPMMQAMAQ
ARMRMMRDLRNALGLNQFTVYFQPIVDLSSQRIHKAEALIRWQHPELGFISPAEFIPLAEETGLIHEIGDWVFQQSAQLVKQC-IPVGDDFQVSVNKSPV
QFRDRTQAQDWMEYLSGLGLSGHNIVVEITEGLLLNADSGISDKLLHFRDAGMQVAIDDFGTGYSSLSYLKKFDIDYLKIDQSFVRNLSGEGEDLALCEA
IATMAHKLDLRVIAEGVETTAQRDLLAQIGCDYGQGYLFSRPVPAEEFMQLLERS-----
>tr|N6XZI4|N6XZI4_9RHOO PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Thauera aminoaromatica S2 GN=C665_05473 PE=4 SV=1
--------------------------------------------------------------------------------AQLRAIFDSSPDGMALKDRN
GVYVDCNAVLARGFGLARAQIIGRS---DDQLFEDKDFATVRKNDAEVLGQGASHRYERRFEAADGTAYELEIVKVPVRAADGAIDGVLVVAHDLTARRR
AESELRIAAAAFES-QDGMMITNGRGVIERINSAFTRMSGYPAEEVVGCTPRFLKSDVHDPDFYSAMWGAVARKGYWAGEIVNRHRDGGLFITRLSITAV
CDTQGRPLHHVCSYQDISAERQARELAERLKLYDQLTNLPNRSLLEDRITHALANSAERGELGAVMMLDLDLFQKVNDSWGHGVGDRLLTEMVRRMQGVA
DNGETLGRFSGDSFVLMLENLGHRQAQDLAEAVRQAIAVPMTIEGRRISSTATIGVTLFRGREASPETLLRQAELAMYKGKNMGRNVVRFFEDAMQSELD
RRNLLEEELREAIENHQLVLHYQVQVDAEGLPI-GAEALIRWIHPVRGLVPPFVFIPLAEETGLIEPIGRWVLATACQQLAQWSYDLFSRLTLAVNVSPP
QFKAASFVQDVFDELERAGVPARTLKLEVTESLAIDDFDASVDKLRQLRARGVRISLDDFGTGNSSLNYLTKLPLSQLKIDKSFVDELPASHRDAMVAQT
IIAMGQGLELDVIAEGVETRAQHEYLVAQGCHAFQGYLFGKPLPVDAFEAAVRER-----
>tr|F3KS11|F3KS11_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Hylemonella gracilis ATCC 19624 GN=HGR_06201 PE=4 SV=1
--------------------------------------------------------------------------------ALLRAIIESSPDAMMLKSPQ
GVYLDCNAGALELLKLGREELLGKT---DEQLLDDPDFHFIRGHDQEVLHGGKPLQYETTFKAQDGSTRNLEMVKVLVHDAQAAPAGILTIGRDITERRR
AERELRIASVAFES-HDGMMIADANGVIERVNSAFTRISGYTPEEAIGKTPKLLQSGLHEPAFYQALWTALKREGHWHGEVVNRHRQGHLYTARLTITEV
TDAGGRTLRYIGNLQDITAERDARALAERLRLFDPLTNLPNRLQIEDRMRSHLDQDLESPTADAVMMIDLDLFQKVNDSLGHVIGDQLLIEMARRISLIA
REGDTVGRFSGDSFVIVAQHLGPRQAQALAESVRRTIEAPVMLDGHRLVCTASVGITLSSGPRSDPGTLLRQAELAMYKCKKEGRNTVRFFEEAMQTEIN
RRRDLEHELREAIEREQLVLHYQLQVDAQGQPL-GAEALVRWAHPRRGLVPPSDFIPLAEETGLIEPIGQWALSTACHQLARWADRETHHLTMAVNISPR
QFKSPTFVDDVVSKIRRAGIPADKLKLEVTESTAIDEFDVSMSKLQALRTCGFMISLDDFGTGNSSLNYLTKLPLTQLKIDKSFIDDLPASHRDAMVAQT
IIAMGRGLGLDVIAEGVETEAQHHFLVEQGCQAFQGYLFGRPQAVEAFEASLLAQ-----
>tr|D7DKL6|D7DKL6_METV0 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylotenera versatilis (strain 301) GN=M301_2093 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--YVNLAACMEREYSLKE--MLQMR---IFD--LDPDYPGIWTPHFEDLSRRGSISLETRHRTKNGRIFPVEVSANYINN--G-KEFNFAVLRDITERKQ
AELALSISELAVDE-HAIVSVTDVQGIITYANSKFCKISGYTEEELLGQDHHILSSGYHPKGFFKEMYLTLATGKPWHDEICNRTKDGHLYWVDTTITPF
MADDGKPKSYISIRTDITQRKAAEEKNNILALYDTLTNLANRRLLLDRLKQALASSARSSRRGALLFLDLDHFKKLNDTLGHDVGDTLLQAVASRLTSCI
REGDTVARFGGDEFVVLLADLSEAFTKDIAEKMIITLNQPYQLKTNIYHNTASIGATLFVGHELEIDELLKQADIAMYQSKNEGRNTLCFFDPKMQEAIA
ARVDLENELRKAIQEQQFQLHYQIQVSSTGQAF-GAEALIRWQHPERGMIPPYNFITLAEETGLILQIGQWVLDTACAQLKTWQQILTQNLLLAVNVSAK
QFFQVDFVDQVKATLQKYDVNPTYLKLELTESMLVYNINDIITKMNALSKIGVIFSLDDFGTGYSSLQYLKMLPLSQLKIDQSFVRDIATDKSDAAIVRT
IITMAHSLGIDVIAEGVETDEQKQFLLDNGCVQYQGYLFSRPVQIDEFDYLIRTK-----
>tr|G8QI39|G8QI39_AZOSU PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Azospira oryzae (strain ATCC BAA-33 / DSM 13638 / PS)
-----------------------------------------------------------------------IRAQLRESRLRLSAVFNQTSEFIGILDLK
GRLLEANQSALDLIGRQPAEVLGQL-FWETPWWVPLVQQRLRQAVERVAAGGEAQRFEVTHMRRDGRLRYVDFILKSVEDEPGQPLQLLAEGRDITDRKE
GEEQHRLALSVFENSHDGILITNPEGLIIEVNRAFCELTGYAREEAIGQPARMLNSGHHDRTYFRQLFQVVSERGFWKGEMWNRTKSGAVTAVLMTVSAV
HDDGGRISHFVGVFSDITQQKENQRRLERLAHYDALTGLPNRTLMSDRLHLAMAQAQRRNKLLAVCYLDLDGFKAINDSHGHQAGDRLLMDVAERLRRSL
RGGDTAARLGGDEFVLLLNDLTASELEQILERLLLSLAAPFALQGQTASVSGSIGVTIYPTDDADADTLVRHADQAMYAAKQSGRNRYQLFDTEQDSRAR
SLREAIVNARAALEQEQFRLYYQPKVNLCSGLIVGFEALIRWQHPEQGILAPAAFLVDLEETDLIVDIGDWVMETALAQLEAWQALGWD-YPVSINIAAR
HLQQPDFLPRLQRALERPAVPPRLLELEILETAALEDVGQVSLVIAACQRLGVGFALDDFGTGYSSLSYFKSLPARTLKIDQSFVRDMLHDPEALAIVEG
VVGLTSAFQRSVVAEGMETVEHGVMLLRLGCIHAQGYAIARPMPAAEVPAWAASFE----
>tr|D9SF62|D9SF62_GALCS Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Gallionella capsiferriformans (strain ES-2) GN=Galf_113
-----------------------------------------------------------------------RRQESLEHSLI----VKTIPDLIWLKDVE
GVYLSCNPMFERFFGAIEADIVGKT-DYDRPWHQ----------IGASYGWG---ASAALPLRRNGAASLPDAYCEAINDTKGQVLAALERASLAIERAQ
TGAWLNKLSQAVEQSPNSIVITDLNANIEYANDAFVKTTGYTLPEVMGKNPRILHSGKTTVETYAAMWTQLNSGQMWRGELINRRKDGTEYVELARISPL
RHTDGRVTNYLSIKEDITEQKQVEARIRQLAHFDLLTGLPNQTLLKDRAGFAMQMAQRSAHHLAVLFLDIDHFKNINDTLGHRIGDELLVHLAKRMKLLL
RDEDTLSRFGGDEFILVLPDTDADGAAHVAEKILETVAKTCYIEQHELVVTPSIGIAMYPSDGMDFDKLYQSADVAMYRAKQDGRNNFRFFTSEMQARSA
RRLLLENALRQALSRNQFELHYQPQISMQDGKIVGAEALLRWYHPELGSISPAEFIPVAEESGLILSIGEWVLRTAVQQVKRWQDAGHPPVTVAINLSAV
QFRQARLSELVMQILHEANLAPHWIELELTESVAMDNPLVAIGVMNDLHGCGIRMSIDDFGTGYSSLSYLRKFKVNKLKIDQSFVRDLADDIESRAIVTA
IITLASSMGFQTIAEGVETAGQLAFLRLQGCNEVQGYYFSRPLTVALFEAFVLGHA----
>tr|D9SE93|D9SE93_GALCS Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Gallionella capsiferrifor
-----------------------------------------------------------------------QSIKLNQLQRPFLDLLDNLP-LVFIKDTR
SNYIACNKSYADDLGIQQSEIAGKS-DLDLAWHEAQYALH-----------GN----ISLPINAPD---------------------FA--IHINTIKRQ
QETELKLAEQVFSRSADAMIITNPDNNIVRVNQAFCEITGYTSEEVIGKNPRILKSEKQDHDFFRSLWRSLELQGSWQGEIWNRRKNGEIYPEWSSINAV
KDASGRVVNYFAVFSDLLQKK-ALAELDHLKHYDALTDLPNRALLEDRIESSITHARQYERFIGVIFLNLDHFHTVNDMLSHAGGDQVLIATAKRLMDAA
PAQASISRLSADTFVIALPDLNTEEINRTAELIAQKIYQPLTVADQSVQLSARMGISVYPIDGNDATTLMKHADAALADAKQCGRNSFRFYSSSMNEHAH
KLLTMGAELRNAISQNRLVLHYQPQVDIITGQIIGAEALIRINHPERGIISPGEFISVAEETGLIIPMGTWVIREACRQMQQWHLDKNIELTIAINLSPL
QLHQSDLPEIVSLALHDSGLNARYLELEFTESAIMKNVRETVAIMNKFKAMGLHLSIDDFGTGYSSLSYLKQFPVDKLKIDQSFVSNITQDPNDAAIVQA
IIALGRTLGMTTIAEGVETEAQLGYLRSVNCKEMQGYLYSAPLPAEEFAALLVRGK----
>tr|A0A0B0HBZ2|A0A0B0HBZ2_SOVGS Diguanylate cyclase/phosphodiesterase OS=Solemya velum gill symbiont GN=JV46_17810 PE=4 SV=1
-----------------------------------------------------------------------RESELTEVRLAESQRLTRIGSW-------
-------------LKYE----TGEL-WWSDELLHVSSFHPEV-FVKAVFSEGNTEELTCLTKSRQ-GRSYLDF-VDEQDTETGQTLAS---VIDVTETKQ
AHERLRLAASVFDNTAEGIVVTDTDGNIIEVNKAFTEIMGYSREEILGRNPRIWQSGRHDINFYRNIWKALIATGSWRGEIWNRRKDGDVYPGWQNINGV
FDEDGKLTQYVSVVSDISQIKQSQEKLDHLAHHDALTGLPNRLLLSERLKQAIRHADRTGTDLALFFLDLDHFKHINDSLGHPLGDQLLQDVAEKLTQSL
RREDTVARVGGDEFVLLLGSVSREDIANMAEKLLKAFRAPVLLNGHELSIGASLGISLYPQDGKSADELLHNADAAMYRAKEEGRNNYQFYTEALTHKAF
ERVLMENNLRQALEKEEFILHYQPQLDLHTGKIVGAEALIRWQQPQLGLISPSRFIPIAEDSGLIMPIGEWVLQEACSQAKKWLDKGIDIGRIAVNVAGP
QLQRGRLVEVVQDVLAKCGLPASRLEIEVTESLLMQKTESAIKQLDELRQLGIVLAIDDFGTGYSSLSYLKQLPIHKLKIDRSFVHDIPGDPDDMAIADA
VIALGKSLGLTVIAEGVETLEQAEFLRGAGCQEVQGYLYSQPVTAEQFEQLISLHE----
>tr|W0SM35|W0SM35_9RHOO Uncharacterized protein OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_03055 PE=4 SV=1
-----------------------------------------------------------------------LRHELVKPGMILGGVLDRIGDGVLADGES
GAYVEANDRAGELLGYSRNEILGRH-VWEEEWMGPFDFITLMAQIKRIDTTD-HRRFQLLARRKDGGLRLADSYCSPEEHDAAGNIIGVEGTRDNTKERQ
VEEELRLAAKVFESSGEAIMITDAGGCMISVNSAFSRVTGYAPTEVIGRNASLLASGRHSREFFSDMWHGMLDSGYWKGEIWNRRRNGEVFPEWLGISSV
RDAGGKITHFVGIFSDISERKAAEAKIAFLAHHDPLTGLPNRLLLKDRMEQAIAHGERTGRKVALLFVDLDRFKAVNDSFGHPVGDVLLRDAAQRLLACV
RDSDTISRHGGDEFLVVLTDLQSEVPAQISGKIMAALGEPFHIDPHEATISASVGIAVYPEDGADFDELLKKADTAMYHAKEAGRNAFRFYTERMNADAQ
ERLDLHGRLRRGLEREEFILYYQPLVDLKSGLVVGAEALVRWQSPEQGLVAPGHFIPAAEHSGLIVPLGEWVLQEACRELVCWHAQGGRQFSMAVNISSI
QFRRGDVEETVRRALAASGATPAALELELTESILIDGAEQVLATIKRLQALGVRLAIDDFGTGYSSLAYLKRFAVDKLKIDQSFVRDIVTDRDDAAIVRA
VIQMAGSLELKVVAEGVETEAVAAALRAMNCDLVQGYHFGRPMPAAEFRRLIGVA-----
>tr|G2HTD7|G2HTD7_9PROT Putative uncharacterized protein OS=Arcobacter sp. L GN=ABLL_0515 PE=4 SV=1
-----------------------------------------------------------------------------DVKEAVIEVFD--------NDDE
QIIYWFNQKANKLFDIKITTLIPKA-RWN-------------------------------------GQKFASFTVEKPE-FTGNIINGEIRFKDITEEEK
IQKKLQLSDIVFENTTEGIIITNERGEIISVNSAFSKITGYSFEEIKGQNPKILKSGKHNIEFYQILWEELIKKGAWKGEIWNRKKSGEIYPEWLNLSLV
KDSEGNILNYVALFSDITKIKNSNAKIEFLAHHDPLTNLPNRLLLKARLIKSIEKANELKYRLAIFFIDIDNFKLINDTYGHSIGDNIISLVANRLQKNI
RKNDTISRIGGDEFIIVIEDVDNKDIEKLAKKIVSDFKEPIKMEEYLFDTTVSVGISIFPNNGLNAEDLIKYADTAMYSAKNAGRNQYQFYKEEMTSEIF
EKIIMKQELTEALKNNEFEVYYQPQIDLKTNTILGAEALIRWNHKTLGVISPENFIPYAEESKLIIPIGEFVLKKACEFIKKLNDLKLLEGLIAVNISNI
QIKYSQVLKTIVKELEHSKLNPQNLEIELTESYIMEDVEESLLILENLKNLGIKLAVDDFGNGYSSLNYLKQFPIDKLKIDKSFIDGLPSNKKDVAIART
IIALGNGLGMKTIAEGVETEEQKEFLRKEGCDEIQGWFYSKALREEDFIKFIKEFK----
>tr|A1SVV1|A1SVV1_PSYIN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Psychromonas ingrahamii (strain 37) GN=Ping_1839 PE=4 SV=1
--------------------------------------------------------------------------ITEKLYYRYTELFEFAPIAYFSFNLK
GVVNQVNLRGASLLDIERANLVGKQ---FSNYLTPQDRDKFNRCLAKAFAGDGIQSFEVLAQI-GKHKRWLNIEANL----GITETDCLAAVIDITDRKR
ADEKLKLAANIFTHTLECIIISDENGYIVEANKASCDTTGYSKEELLQSHVSI-----LESSQYEKIETALQKDKSWQGDMSYRTKNGEHHYCWSEMYVI
LEEKGTLCRI-SSFIDLKQSTRVEPKIQFLSKHDPLTGVFNRIALFNRLEQVIARASFNQRMMAVLLVDINGFKAINKQHGHNAGDMALQQIAERLKSCV
SEKDTVARFGGDEFVIIIDELLNQDVADVAQNITAQFERYFDIDHSSAHLSATIGIALYPDDGTDIDTLLGNAEKAMQRGKSHQTTTYYFYTKKLTQYSR
QQVKFKEALTQAVAQDQFELYYLPQYDLSKRQIVALEALLCWNHPQRGVLHSDSFISLAEHYGLAVQIGLIMIRKAALQAVIWQKAAINFGRIAINLTEV
QLSQFSLIGDLQTILLETKCSIEWLEFEIDEVTFKSDNPTVYENILNISKMGMALTVDKFGADRPLFRLFEQLTIDKFKIAPHFTDGSVN-FVNRALQDG
FLFLSRSLGVTVVADSLANNTDGEPAISNEVEPASQQLHSKAMKASEITFHLRC------
>tr|H8Z8J2|H8Z8J2_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiorhodovibrio sp. 970 GN=Thi970DRAFT_04916 PE=4 SV=
--------------------------------------------------------------------------TLATSRARYFDLYDLAPVGYLTLSED
GVIQEANLAAATLLDTPRETLVDQP---LTRFILPEDQDTHYHARHQLLATGERQTYDLRLCRA--ALAWVHLDISQRPDATSEHIIWSAILSDISARKR
DEQAL-----------LTFWEWDPKTQAVFFPPEWWRQTGY--------LPHRLGAHPDDRTRILEHLN---------GFVDAPLRCKDGDERWFVARL-
LDTQGALMHVLLVQQDITRRKVAEDEAIRLAQHDPLTGLPTRALLDQLADRMLASTRRTGDQLAVLFFDLDRFKAINDIYGHSVGDQLLQAVAQRLRESF
READLIARLGGDEFIAVLANLNDDDAARAARTAIAALTPPYPIGELMLHCVPSLGISLFPQDGDSIESLIQGADHAMYHAKEVSPGGYQFVTDALNQQAH
TTLTLETRLREALSQQEFRLAYQPLLDPHNSRITGVEALLRWPQTDAGEIAPLVFLPVAETSGLIHEIGHWVLQEVGRQYGAWRQRGLPPIPITVNISAR
QFHHQRFHDQLAAALQASAMDPADLTLTLSEAALMQDMLTARQRLDALKALGVRVALGDFGLGCSSLNALERLPLDRLEISRALVERLNLAERLPVILDT
LIGLAQALQFDVKAVGIETEADLDFFRQRECDQVQGFYLGVPMSAEQFTDWYRQ------
>tr|I3YBZ0|I3YBZ0_THIV6 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiocystis violascens (strain ATCC 17096 / DSM 198 / 
--------------------------------------------------------------------------ELEISRARYFDLFDLAPMGYLTLDEA
GLVEEANLAAATLLGIPRAELVGRP---LTRFILPEDQDAYYSCRNRLWSTGERQVGELRLRCD--QSVWIRLETSLSRDARSAHTIWRATLSDITERKR
SERDL-----------LTFWEWSPNTDEVHFPPEWHGQTGY--------APKRLGEHPEDGEPILFQLT---------GFVDAPLRRKDGLYRWFVARL-
QDARGQVERVLLVQQDVTARKQAEDRAIEVAQHDPLTGLPGRALLEHVANHMLASARRAGRQLAVLFFDLDRFKAINDAYGHPVGDRLLRAVAQRLLDTF
RAEDLVARLGGDEFVVVLSHIRDDDAARAARNAIVALTPAYAIEGLELPCVASLGISLFPQDGDNIDCLIQRADLAMYHAKQFSPGHYQFVTEALNRKVC
DETRLEARLREGLSGNEFRLVYQPVLDTRSGAVTGVEALLRWPQPDRSDVAPQNFLPVAEFSGLIHELGRWVFQEACRQHLAWRNSGLPPIRIAVNVSAR
QFHHQGFLGQLTAASEAAGIDPGALSLELSGAALMQDKEGSQRLLGELKQLRVGVALDDFGMGCSAIGELEQLPLERLEINRALVQRLGSTDSMPAVLKT
IIGFGHALKLDITAVGVEAESDLEFFRAHRCNQVQGFFLGVPMSGERFVGWYRE------
>tr|G2E272|G2E272_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_2385 PE=4 SV=1
--------------------------------------------------------------------------ALEQSRTRYFDLYDLAPVGYITLDQS
GIIQEANLAAASLTVTPRTSLIGQP---LSRLIHSEDQDIWYLSRQRLRSTGDRQHCELRLQQS--TTRWTCMDTRLETPTDPNTCSW-IILTDITEHKE
SERQL-----------LSFWEWTPHTNAIYFPPEWRRQTGY--------LPQSFEEYPQDRERMLERLD---------AIAAGRLRHKDGDYRWFSARL-
LNDSGHIERILGVHQNVTQRKLAEDQALQLAQHDPLTGLPTRGLLEQLANRMLVNAKRSGSQMAVLFVDLDRFKAVNDTYGHAVGDQLLQSVAQRLRETF
RAQDLAARLGGDEFVVVLADIRDEDAARVAQTAIDSLSRPYPIDGLDLIVRPSIGISLYPEDAQTIGDLIQRADLAMYHTKQVSPGHYQFVTEALNRQAQ
TTLALERRLREAISQQAFRLVYQPMLDFQSGDIVGVEALLRWPQPDGTEIPPLSFLPLAESIGLIHELGQWVFEEVCRQHHAWQKAGLPLVRIEVNVSTR
QFRHQSFLSHLAQTLRTSGVEPSVLSLELGEATLLQDLPTARHTLAGLHDLGVRVALADFGMGCSCLSEFDDLSLDRLGINRALVRRLDGP-NMQAIVET
IVRLGQRLQLDVIAVGIETEAQLDFFRDLGCNQVQGFSLGAPMTGDAFVDWCHD------
>tr|L0H0W1|L0H0W1_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thioflavicoccus mobilis 8321 GN=Thimo_2490 PE=4 SV=1
--------------------------------------------------------------------------ALEVSQARYFSLYDLAPVGYLSLSEA
GLIEEANLTMTNLLGTARDDLIHKP---LTRFIAPPDQDTLYRCRQRLWSTEEPQTCELRLRRP--SPIWVRLETSIRTESPDGRRLWLVTLSDITCLKE
GERAR-----------VTFWEWHPRTDEISPPPGFGPRSGPKSEPDSAQARQRLDDHPEDQERFRTDLA---------RFVAAGRRCQDENYRWMLARL-
AGDHSPLDRVLLVQQDITRRKESEDWAIRLAQHDPLTGLPSRSLLVQMAEHMLASARRSGGALAVLFFDLDRFKPVNDVHGHAVGDKLLQALAQRLRGAF
RAEDLVARLGGDEFIAVSPNIHSDDAAQVAGRAIAALAPAYRIDGLELHCLPSIGISLFPRDGDSIDELIQRADQAMYQAKRVGHGQFQFVTEALNHQAR
LAQELEDRLRQGLAHAEFQLVYQPVLDIRDGMIVGADALLRWPQAGGGDIAPKTFLPVAEASRLIHEIGHWVLREATRQQQAWCAEGLPPIPMAVNISAR
QLRHPAFLPEVAAAMQASGIDPAFLTLVLGGASLMQDVEAARRILDELKQLGVRLALDDLTLSGCGLGVLKALPLDQLKIKRDLVRCLGVVGYMPAMIDA
VLCLGRALQLDVTAVGIETEAELEFFRQRDCYRVQGFHLGTPMAGDRFANWFRG------
>tr|F9UFF7|F9UFF7_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_3660 PE=4 SV=1
--------------------------------------------------------------------------ALEISRSRYFDLYDLAPIGYITLTDT
GTIQEANLAAATLLETPRVNLAGRP---LTRFILPKDQDILYRCRHRLTTTREPQTCELRLQRA--PPCWVRLDVCLEPHRTGHQGHWRATLSDITATKE
GEQSL-----------VGFLEWNPRTGAIVTPPAEQAPPGK-------ASPRSLDAHPDDRERVRADFA---------RFAAGGRRSKKDDYRWFACRL-
PDTEGRFDRILIVHQDITRRKESEDKAIRRAQLDPLTELPTRSLLDPMATQMLAGAGRSGRRLAVLFVDLDAFKAVNDEFGHSVGDEVLRQTAQRLRACF
RAGDLITRLGGDEFLIVLDNILDDDAATAARTAIDALSRPYPIADREVTCPPSIGISLYPDDGATIDALIKGADLAMYHAKQVSPGQFQFFSAALDRQSR
AVTVLQDGLRDAVSGNGFRLLYQPVLDLGSGAVVGVEALLRWPQPGGGEIAPSVFLPIAESIGLIHDVGAWVLREACRQHRAWLDAGLPPIAVTVNVSAR
QFRHRSFLRQLTDALLSGGVDPSLMSLAVGEATLLRDRSASRQLLAKLHALGVHVVLDDFGLGPSCLGEIEDLSLDSLEINRTLLHRLDDRPHAPAMMET
IVRLGRAMQIKVTAIGIETEAELTCVRDLGCDQAQGFYLGKPMTGSELADWYRR------
>tr|F9U6G5|F9U6G5_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_0516 PE=4 SV=1
--------------------------------------------------------------------------ALETARSRYFDLYDLAPIGYLTLTEE
GMIREANLAAATLLATTRVGLVGRP---LTRFILPEDQDILYGCLHRLRSTREPQTCELRLRKT--VSRWVRVDSALEAHRMGNQGHWRATLSDITASKE
AEQHL-----------VGFLEWYPRTGTVLLQPAVHSSTSD-------AAPQTLDAHPEDREPVRTAFI---------HFATDCQHSESGDYLWFAAYL-
MDDRGLLDRVLIAHQDVSQRKESEERALRLMQHDPLTGLPGRSLLTPMAAQMLAGAGRAGKRLAVLFVDLDQFKAINDNYGHAVGDEVLRQTAERLRASF
RADDLVARLGGDEFVIVLANIRDDDAATAAGTAIAALARPYRVAEQELTCLPSIGISLYPDDAATIDALIKCADLAMYHAKQVSPGQFQFATAALERQSR
AVAVLKDGLREAMSHNGFRLLYQPAIDLRSGAVIGVEALLRWPQADGSEIAPLVFLPIAESIGLIHDLGAWVLREVLRQHRAWLAEGLPPIAVTVNVSAR
QFRHQSFLQRITDALHDGGVDPALVSLALGEATLLQDTSTSRRLLDKLHALGVRVALDDFGIGSSCLGEIEDLPLDALEINRTLVQGLDNGARAPAIVET
IVRLGQALQVKVTAIGIETEAELGAVRDLGCDRAQGFYLGKPMTGDELAAWYRR------
>tr|A0A011Q1E0|A0A011Q1E0_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-92 GN=gmr_3 PE=4 SV=1
--------------------------------------------------------------------------ELDATRARYFDIYDLAPVGYCTLSEQ
GLILEANLTAATLFGITRGELARQR---LSRFILKADQDIFYLHRMQLLADGQRQACEMRMVAL--APFWAHLETVPAL-ASDGRRVLRTVISDITERRQ
TEAEL----------QQAMLVTDANRIILRVNRAFTQMTGYSAEEAIGQTPFMLESSRHDADFYRAMWKTIDRKGCWQGEIWDRRKDGETYPKWLTISAV
KCSDGSVTNYVGMQYDITERKVAEEKIEELALFDSLTHLPNRTLLRDHLKQAMTTGQRSKTFGALLFVDLDHFKALNDTKGHHQGDLLLKAVAQRLTASI
RESDTVARLGGDEFVVIMGNLHRTQAELIGEKILIALNQPYRLDDADHQGTASIGATLFRGHETSSDDLLRQADLAMYKAKAAGRNSMHFFAPAMQAVVL
EHAALEASLRMAIQEDRLVLHYQAQVAAD-GRVAGSEVLLRWQHPERGMMAPTDFLPLAEATHLIVPLGYWVLETACKQLAAWAARPMAPLTLAVNVSAQ
QFREADFVEQILAILTRTGADPRRLSLELTESLLVEHAQESIEKMLALKARGLGFSLDDFGTGYSSLSCLQRLPLDQLKIDQSFVRNILSNPSDAEIARI
VVALARSRALTVIAEGVETQAQRDFLEASGCYLYQGNFFSQPLPIEGFEEFVRR------
>tr|Q5P5U6|Q5P5U6_AROAE Azoarcus aromaticum EbN1 complete genome OS=Aromatoleum aromaticum (strain EbN1) GN=ebA2147 PE=4 SV=1
--------------------------------------------------------------------------ALEDARDRYSDLYDFAPVGYMTLDEH
GVILEINLTGARLLGQDRAQVIGMP---LSGWVPNGAVAQLFHHLRRVLSEPGRVFDHLPL--HRESPIRHVRLESIAFTQYGSGRLCRTALVDLSDRKR
EEDRLNLIAQVFERSTDAIMITDSLNRIVSVNRAFTTVTGYSADEVLGRNPKLLASGRHDRDFYREMWSAIERNGSWSGEISNRRKNGEIYNEWLTIHAV
RNESGGIENCIAIYAEITDQRAAASRIQFLAHYDPLTLLPNRALLQDRMHQGLAHAAREGTRAAVLFLDLDRFKTINDSLGHLVGDHLLQEVAQRLKASV
REDDTVARRGGDEFIVMLPHVDSEQAAHVAGKIIEAMEQTIPVNGYVLNVSFSIGISVFPDDAMDPDTLIRNADIAMYRSKASGRNQFQFFTADMNAHAL
ERLALENDLHRAVERGEFRLMFQPQFEGS-GSIIGAEALLRWQHPQRGLVTPAEFIPVAEETGLIVPIGTWVLERACQQVRAWRDAGLKKITVSVNISAL
QFSQKNLLELIRRLLAVSNIEPGTLELELTESVLMHDHVATSGLMSELKEMGVRMAIDDFGTGYSSLSYLRSFPISKLKIDQSFVRDLSDGGDAGAITGA
IIGLAKNLNMRVIAEGVETAQQASFLQAQCCDEFQGHFFSQPVSPEKFAELLRA------
>tr|G3IYX7|G3IYX7_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_3278 PE=4 SV=1
--------------------------------------------------------------------------EVEASLERYTELYDMAPVGYLTLGRD
GAIQQINLRAARQLGIFRSQLKQQR---FSSFISVDSLPVFNDFLSGVFVGKT--AQSCEL--TDRSPTLIIQFEAIA---NDDEQTCRVILIDITERKG
NEDKLKLANLVYQAIGEAIMVADADNRIVTVNPAFTELTGYSLQEAVGQSTTLLKSGHQNEAFYQIMWHALETTGHWQGEIWNRRKSGEIYLEWLTINTV
YDDQNKVRHRVATFSDITDQKHAEQTIWQQANFDSLTGLPNRHLFYERLEQEMKKSRRVGLPLALLFLDLDHFKDVNDTLGHCKGDLLLKEMAQRLLNCV
RSTDTVARLGGDEFTIILAELQEDSIERLAQDILCQLTKPFELAGEIAYVSVSIGITLYPEDTDDIDVLIKNADQAMYAAKDQGRNCRHYFTISMQEAAL
TRMRLINDLRNALVERQFWLAYQPIVELTTGFIHKAEALIRWQHPTRGLISPADFIPVAETTGMIIDIGEWVFREAAQQAAQWRTKHHNEFQISINKSPV
QFQKEDNGHLAWEHLRELGLPGESVVIEITEGLLMDAGALITGQLLAFRDAGIQVSLDDFGTGYSSLSYLKKFDIDYLKIDQSFTRNLSPDANDLALCEA
IIVMAHKLGIKVIAEGIETQEQCDLLMAAGCDYGQGYLFSKPVAAGEFEKLLGA------
>tr|Q1NRH1|Q1NRH1_9DELT PAS:GGDEF:EAL:GAF OS=delta proteobacterium MLMS-1 GN=MldDRAFT_4269 PE=4 SV=1
--------------------------------------------------------------------------ELEESRDRYVELYDFAPVGYVTLDPK
GRIREANLTAATMLGSERSRLYQRG---LGRFVSQEYLEPWYLHLAAARKGDDRQECELLLQRD--TSFFAHLASKRVVKEESGERFIHTTLTDITQRKE
TETELELVARILETIDEGFIIIDHEFKIVSANRAYAESAGYPLAEIIGRHCYQVSHQIDQPCY-------LNGEDCAVQHVFNTHYTAAGEPLYVETKA-
RDDLGTVRRAIEVVTDITDKKNREQEIHRLAFYDPLTRLPNRRLFFDRLEQAISASARSGQHGAVLFLDLDNFKTLNDTRGHDIGDLLLTMAAKRIQETV
REDDTVSRQGGDEFMVLLNNLSPSQAGRVAEKIRAALDQPFDLDGYEHHIGVSIGIGLFMGHDTSVDELLKRADAAMYQAKNAGRNQVRFFDPEMQAELE
QASALVMDLRQAIWQGQFQLHYQPQTAND-GRIIGAEALLRWTHPERGPVSPMQFIPLAEESNLILAIGRWVLEEACGQLAAWADLPAGNCKLAVNVSAR
QFRQPEFVAEIRRILAATGADPKLLKLELTESIVMTELADTVSKMHELRDLGIGFSMDDFGTGYSSLAQLKRLPLEQLKIDRAFVRDLGSDPHDDAIVET
IIAMGRTLDFQVIAEGVETKEQLATLTRYGCDAYQGYLFSRPVPAAQFAHLLTS------
>tr|F9U8V6|F9U8V6_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_1358 PE=4 SV=1
--------------------------------------------------------------------------RTQTALNRFMAFFDSLPVAELVVDGQ
GLVKEANEEARRLFGLRDTVYHQYF---FVRLIEEPDRGVAIHAFANLHPDAPIDLHELRFRTK--KVFIGDLHMAALPSDADEGRRVLCAVVDRTDAVL
QREALYRVIAEFSSDWEYWI--GPDAQYRYVSPACMRLTGYPSAAFIADPDLFAR-LLHPDD--RHLWTQHL--GAHLGDESGGIRHLDGHEYWIEHSCT
FGESGDFLGRRGVNRDITELKRSREQLHFLAQHDALTGLPNRSLFRQRLEEAIPRTIRRGGETALLFLDLDRFKIVNDTLGHPVGDRLLRQVAARLTQAV
RASDTVARLGGDEFVVISEEVGENDAALLARRLLDLFATPFDVDGRELFLSLSIGIGIYPLDGMDVDTLLRHADIAMYRAKAAGRNGFRFFDPEMSEGAA
ERLRLEQELRNALPRDELLLEYQPQVGLPDGKLCGVEVLCRWDHPRLGLLSPAHFLPLANDIGLIDQLDLWVLEHACGQVAAWDRGGFSVPRLAVNLSVQ
RIQSNDVLEKIKSILARTGMDPRRLELELTEASIMDRPASTIANLGQLSGLGIGLAVDDFGTGCSSLACIKRLAIRRLKIDRSFIERLTTGSDDEAIVHA
VIGLARSLGLAVLAEGVETAGQADLLIRGGCDEAQGYFFGRAVGAAELASRYSS------
>tr|C6DZH0|C6DZH0_GEOSM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Geobacter sp. (strain M21) GN=GM21_0472 PE=4 SV=1
--------------------------------------------------------------------------ELVRELQVYTDLYEFSPVGLFTLDAA
GNIRSVNNTGAGLLGKPRPELVGVP---FEQAVAEPSKGDFSVLLNDARTSQSKSACELTLVSA-----PVR----IDALCCKEGTEYRLSVLDITKRKQ
SELALEQCRTIVSNINEYVRFEEGDITSVYHSPKCFDITGYTPEEYYRD----PLLHEEDRNLVVEFLN----------GIFAGIIHKDGSVRWIVNNCA
RGDRLSITRLDGFILDVTDIKRAEENIFFLAHHDPLTKLPNRSTLYERMEQVICAAQKSSRNVALLFLDIDGFKQINDSMGHDVGDRLLQSVAKRLSDCT
RSCDVVSRLGGDEFVVMLWDCGE-ETTVVAEKVI---NAGFPVLGSNVTVTPSIGISIFPDDGRDYLTLLKHADIAMYHAKKSGGNNFQFFTHKLNEIAH
ERFMLEAELRRALDREEFVLYYQPKVDLSTGKFSGMEALIRWQHPAHGLMLPESFIGIAEESGLLTQISKWIIPTVCRQIQQWQQQGINSVSAAVNLSAS
FFQHPDFEETIEESLLQTGIAPECLELELTEATIMSDPQRVLGSMAAMKALGLQLSIDDFGTGYSSLSYLKKLPVDKLKIDQSFIHNIARDADNAAVVRA
VISIGRSMQLRVIAEGVENASQLAWLQAEGSEEAQGYYFSRPLPVAKMTSLLKQ------
>tr|E8WSJ8|E8WSJ8_GEOS8 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Geobacter sp. (strain M18) GN=GM18_3923 PE=4 SV=1
--------------------------------------------------------------------------ELASELKLYTDLYNCAPIAHLTLDRT
GVIRGVNYTGTRLLASQPTALIGRS---FCDLLCESCRPSVDALFDSILTTNRRGSCDVTLAEY-----QVR----IEAQACREGSEIRLALIEITE---
SEKALEQCRTIVSNINEYVRFEHGDIKSVYHSPKCLDITGYTPEDYYKD----PLLHEEDRDQVVQFLN----------SIFAGIVHKDGTVRWILNNCA
KGERVAISRLDGFILDITEIKRAEENIFFLAHHDPLTRLPNRSTLYARIEQVLSVAQKSRRNVALLFLDIDGFKQINDSMGHDVGDRLLQSVARKLGDCT
RSCDVVSRLGGDEFVVVLWDCGV-ETTMVAEKII---NAGFPLPGTNVTVTPSIGISVYPDDGRDYLALLKHADIAMYHAKKSGGNNFEFFTHKLNELAH
ERFAIEAELRRALEREEFVLHYQPKVDLITGRFSGMEALIRWQHPVRGLIMPEQFISIAEESGLLHQISKWIIPTVCRQIQQWQRQGIRSVSAAVNLSAS
FFQHRDFEETIEASLLETGIPPECLELELTEATIMSDPQRVLGSMAAMKALGLQLSIDDFGIGYSSLSYLKKLPVDKLKIDQSFIRNIARDSDNAAVVRA
VISIGRSMQLKVIAEGVENASQLAWLQAEGSEEAQGYYFSRPLPVQKMTALLVQ------
>tr|Q47IA0|Q47IA0_DECAR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (strain RCB) GN=Daro_0675 PE=4 SV=1
--------------------------------------------------------------------------ALEAAEQRYRNIFEHASEGIFQSTRD
GHYLAANPALAKLYGYDNAQALMTD---LA------------DIERRLYVQPNRREEFLTLIEKDGSRIWISENAHVVFGPQGEFICYEGTVQDISERKR
TEAHLQLMAMVFSNSNEAIIVTDASNRIIATNPAFTCLTGYQPDDVIGKNPRILSAGTTPTEVFSDMWTCLHREGAWQGELWDRKKNGEAYPKWLSISLV
RDEDGQIRNHIGSFIDISELKATQERIRHLAHHDTLTNLANRFSLHEKLAQALAFCKRNRMQLALMLIDLDRFKTINDTLGHQAGDELLVQVAKRLSHAV
RESDIVARLGGDEFVIALPGIGSADAAHLADDITREISAPYLIKGQELRTSPSIGICVYPGDGSEIGDLLKNADVAMYHAKANGRGNYQFFTEDMNIATT
ERMCLESDLRLAITRREFLLHYQPQLDLRSGTIVGVEALIRWQHPTRGLVSPADFIPIAEESGMIAAIGDWVLEEACRQLKVWQNRGITHLRMSINLSAG
QFLDKTLPARIHELLAANDLSADRLDLEVTESMSMASPDESISVMKTLSSSGLTLSIDDFGTGYSSLAYLKLLPIHTLKIDRSFVKDIESDPNDADICDV
TVLLAHKLGLEVVAEGVETEAQLKFLLSIGCEKVQGYLISKPLPADQAERFIRN------
>tr|W9GX49|W9GX49_9PROT Uncharacterized protein OS=Skermanella stibiiresistens SB22 GN=N825_30110 PE=4 SV=1
---------------------------------------------------------------------------LGADEKRLSLIVEGCPMPIFVIDAA
HKVTHWNRACELVIGVAASDMIGTR---NQRRIFYGLDRPCMADLDGAPDDTVRSYYQDKFRRSGAGPRWLSFTAAPLYGEDGTIIGAIETLLDVTGRRT
AEAGLEMAASVFRHTVEGIFVTDGDGVIISVNPAFTQITGYEEHEAVGKSSRLLRSTTENEEVIAELWDRVRADGNWQGQMWNRRKNGDIFLEWVTITQV
LDATGRPYRYVAIFNDITDLHRKDEQIKHQAYHDALTGLPNRLLLADRIEQAVALARRQDTGVALLFIDLDHFKTINDCLGHDMGDRLLVEVARRLKACV
RESDTVARLGGDEFIIVVADADPDGVPQVCQRIMKALRAPFELPQV-ERVTASIGISLFPGDGADPDTLLKHADIAMYEAKRLNRDTISFFKSDMTRKMM
RRLELEGDLRRAIESDELAVHYQPKAEIATGEIYGMEALVRWFHPTRGLVPPDEFIPLAEEIGMIVPIGEWVLRTACRDAVELRRRG-MPLHLSVNLSMR
QFREVDLVERIASIIKETGLQPAALELELTESILMTEAASAIAALNEIKGLGVSLSIDDFGTGYSSLSYLTKLPIDILKIDRSFIQHCGHDGNSATVVSA
IINLAAQLGHIVVAEGVETVAQLAFLRERNCSRIQGYLIGKPVPIETFVAQLER------
>tr|H3ZE71|H3ZE71_9ALTE Response regulator receiver modulated PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Alishewanella jeotgali
--------------------------------------------------------------------------SLTKSEYILDQTIEKAAAGIAHVSPS
GQFLRVNQELCRLLGYSMAELRELS---FQQLTHPMDLARDQALVEETL--------------SDGQVIWARLSVSLIAATDISDTFFVSVIQDISDVKL
AQLKL------------SVQGYDEDGTTLFWNKGSELVYGYSSQEAIGRLI--IP--EKMQEGVREAVS---------QMASSGLKRKDGSPVTVYSSHA
PDKK---PQIYCIDIDLTTYKQQEAQLAFLAQYDPLTHLPNRHFFANQLEQALKVARREQLQLAVLILDLDNFKNINDSYGHNVGDQLLKQVAEKLRICC
RDTDTLARLGGDEFAILIEHLEQEDAARFAQELLRTMQQTLMLPDLELSAAASIGISLFPQHHDNVEALLQGADAALYKAKAEGRNTYYYYSDQLTAQAR
QRLVLEGRLRNAVKTGQLHCYYQPQLEVATGRIIGAELLLRWRDPELGFVSPEIFIPLAESSGLIHALGIQVLQQACVQGKAWLDEGLPAISLAVNVSAH
QFSRGELGQQVRTLLAETGFPAKFLELEVTESALMQDEDKVIETMQQLRATGVRLAIDDFGTGYSSLAYLQRLPLDILKVDRRFICNMTTNPDNQQITKA
IIELGHTLRFEVLAEGVETAEQLAMLQQMSCNYYQGYYFSKPVPAETFRQLLAQ------
>tr|I9P1K1|I9P1K1_9ALTE PAS sensor-containing diguanylate cyclase/phosphodiesterase OS=Alishewanella agri BL06 GN=AGRI_10431 PE=4 SV=1
--------------------------------------------------------------------------SLLKSEYLLEQTIARAAAGIAHVNAD
GQFIRVNDELCNLLGYSATELLTMR---FQQLTHPMDLSRDQGLLHEVL--------------QNGQIIWARLSVALIAETENSEPFFVSVIQDISDVKL
TQMKL------------SVQGYDEEGKTLYWNKGSEKVYGYSRKEAVGRLI--IP--EKMQDGVREAIN---------LMASSGLRRKDGSPVTVYSSHA
PDKK---PQIYCIDIDLTDYKQQEAQLAFLAQYDPLTHLPNRHYFANQLDQALKVARRENLQLAVLILDLDNFKNINDSYGHKTGDLLLQRVAEKLQICC
RETDSLARLGGDEFAILIEHLDTEDAARFAQELLQNLQQPMLLEDLELSTAASIGISLYPTHHDNVEALLQGADSALYKAKSEGRNTYYYYSDQLTAQAR
QRLVLESRLRQAIKKQQLRCYYQPQLDIKTGSIIGAELLLRWQDPELGFISPDLFIPLAESSGLIHLIGQQVLQQACIQGQAWLNEGLPPITLAVNVSVQ
QFGRGDLEQQVKMVLAESGFPARLLELEVTESALMLDEEKVVLTMQQLRETGVRLAIDDFGTGYSSLAYLQRLPLDILKVDRRFIANMTANTDDRQIAKA
IIELGHTLRFEVLAEGVETAEQLALLQEMACDYYQGYYFSKAVPAEEFRRLLLQ------
>tr|I9W2M2|I9W2M2_9RALS Putative signal transduction eal-ggdef domain transmembrane protein OS=Ralstonia sp. PBA GN=MW7_2791 PE=4 SV=1
----------------------------------------------------------------------------GTWSNGMFKLFGLKPVAKAPSTD-
-----------ELAGM----------------LTPQSFG------------RARKM--LELLVADGDHRWLQLRADIERDANGEPVAVLGAAQDVTAQRQ
SNEQLRLLRRVIQSAACGIDALQEDLPLVYVNPAFEAMTGYRADEVLGRNCRFLHSTESGQAALNEVRAALR-----------ENFRKDGQL--FLNQFL
RNAEGKVTHYVGIQEDVTEREMARQRVAEHTMTDPLTSLPNRYLLMDRVSQAIGVSAAAQQRFYFALFNIDRFKVINESLGHVGGDKVLRRIAERLTKMV
GPADTVARFGADVFALIISHTTI------NGFDLDLFDTPLMVDDTDVFVTTSIGIAEYPTHGHDFETLFRHAEIAMYQAKSSGGNRVEFFRPEMDVGVS
HRLNLEHEIREALAAQQFRLLYQPQIDAVTGRICGVEALIRWLHPTRGVLPPAAFIPMAEESGLIVDIGNWVLEEAARQRAAWREIGEDDVVICVNASPL
QFRRGTVLPTLLRLKREYGFDSGFLEIEVTESMLMDSAGRMIEDLMAIRQLGVKLSIDDFGTGYSSLAYLKRLPIDMIKIDRAFVNDVTTDPNDAVICTT
IIALAHNLGVKVCAEGVEGQEQSDFLRQQQCDVLQGYHFSAPVLPDVVTDMFTS------
>tr|W1LC21|W1LC21_RHIRD Diguanylate cyclase (Fragment) OS=Agrobacterium radiobacter DSM 30147 GN=L902_22785 PE=4 SV=1
-------------------SWALILVWLFGSWLTVTGQLDNDIV-----QPALGGGLVLIVLLIGFTVIQHYQQGLFSDLERQSLALTGSGDTVWDWDVT
RDRIVTTPDISNRLGLEPGAMHGAARNWL-PRLHPDDRDRFKATLDVLLDHKGRLNHEFRIRAEDGHFHWLQIRAR------------------------
--------------------------------------------------------------------------------------------------PV
LGSNGEIIRCVGTITDITEQKNSVERLLQDAMNDNLTGLPNRQVFLDRLQSILNLSSDDGVRPTVMAIDIDRYKLVNDTLGIAAGDNILIALTRRLRRLL
KPQDTLARLGGDEFGLILTSERDQRVADFADAVNKAIMVPINFANREIILTASIGLVSWIDQQESAAGLLSDAELAMYRAKRAGGNRVEPFRPAFRTSGT
DRLQMESDLRRAIERKELSLAYQPIVKLDDGELAGFEALMRWEHPKRGNIPPSEFIPIAEASGLIEPLGMFALERAATDLMDWQHAIEKPIFISVNISSA
QLLNNELYNDVRGMLTRTRCNPQQLKLELTESVVMENPEQARLVLSKLKETGLSLAMDDFGTGYSSLAYLTRFPFDTIKLDKALVAN-TSD-KRNVLLRS
VIAMARALDMQVVAEGIETPEDAAELARMNCHFGQSFLFGTPVSGDAALKLLRERF----
>tr|A0A090N831|A0A090N831_AFIFE Cyclic di-GMP phosphodiesterase Gmr OS=Afipia felis GN=gmr_4 PE=4 SV=1
-------------------TWFLFLVWVIAAGMTVTGAVTNDIV-----GPALLGGLVLIMMLIGFTVMQHTTSGVVSDVERRALALTGSGDLIWDWDVS
ADKVFTSPETEGLLGLKRGTLEGPAARWL-EVLHPLDQDRFRAALDSVLDQRGRLVQDFRLRTPDGHFMWFALKAR------------------------
--------------------------------------------------------------------------------------------------PV
VGSDGEVARVVGTLSDVTEIKNAEERMLHDSVHDNLTGLPNRQLFMDRLNEMASFIKTPNLRPTVMVIDLDRFKQVNDSVGIAVGDSILLTLARRLARIL
KPQDTLARLAGDQFGLLLTSEHEAKITALAETIRKTIRAPIAFNEREIFLTASIGLALSDPQAPLTDEIVKDAELAMYHSKRIGGDRIDVYKPPMRARKT
DRLTLESELRRAIERQEITILYQPIMRLEDRAVAGFEALARWDHPKLGRMSPSEFITIAEEIGLIVDLGQFVMDTTARQLSAWQRATTRPLFASVNVSSR
QLLRHDLIHDVRGVLSRSAVARGSLKLELTESLVMENPEHAAQMLHRIKELGTGLSLDDFGTGHSSLSYLQRFPFDTIKIDQSFVRTTRNG-VRPTLLKS
IIAMAHDLGMEVVAEGAETDSDAVELYQLGCEYAQGFAFGEPMDAASATRLLTGDK----
>tr|A0A0D7F2Q6|A0A0D7F2Q6_RHOPL Diguanylate cyclase (Fragment) OS=Rhodopseudomonas palustris GN=OO17_05000 PE=4 SV=1
-------------------TWFLLVVWVIASGMAVGGYVTNDIV-----GPALLGGLVLIVMLIGFTVMQHATNGVVSDVERRALALVGSGDLIWDWDVS
ADKVFTSPETEALLGLKRGTLEGSAASWL-EVLHPLDQDRFRAALDSVLDQRGRLTQDFRLRTPDGHFMWFALKAR------------------------
--------------------------------------------------------------------------------------------------PV
VGSDGEVTRVVGTLTDVTEQKNAEERMLHDSVHDNLTGLPNRRLFIDRLGAVANFAKTPSLRPTLMVIDLDRFKQVNDSVGIAVGDSILLTLARRLTRIL
KPQDTLARIAGDQFGLILMSEQDARITAFAETIRKTIRAPIAFNDREIFLTASIGLALSDPQTQLTDEIIKDAELAMYHSKRIGGDRIDVYKPAMRARKS
DRLTLESELRRAIERQEITILYQPIVRLEDRSIAGFEALARWDHPKLGRMSPVEFISIAEEIGLIVELGLFVMDQTAKQLAIWQRAMSRPIFASVNISSR
QLLRHDLIHDVRTVLARSAIARGSLKLELTESLVMENPEHAAQMLTRIRELGTGLSLDDFGTGHSSLAYLQRFPFDTIKIDQSFVRTSSRG-TRPVILKS
IIAMAHDLGMDVVAEGAETDSDAVELYQLGCEYAQGFAFGEPMDAEAAMRLLNEER----
>tr|C8X5M7|C8X5M7_DESRD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfohalobium retbaense (strain DSM 5692) GN=Dret_2442 PE=4 S
-----------------------IYVLVAGVWIVFSDSIVAQLAPSSGLFFVAGTGILLYVLIRGYAES------LRQKERHNRLTQRAAKACSWDWDIE
ADRFTWAGDVSSFLTEGDGTLPRTYQDVL-RHIHPEDIPNFERAVQESLL-DQELHLEFRWQRGANTRWFFAVGEV------------------------
--------------------------------------------------------------------------------------------------ER
DLTTNKPQHLRGIIRDITQRKQAEQELAYKSEWDGLTGLLNRSFFLKRLEQLFQTQRRGHCSFAVLLLDIDRFSRINDSLGHWVGDAVLQEASRRLANFL
SPADSLARLSADEFGILLQASNDDQVLRSAHHILEVLKTPMHLSPHDINITASIGVVTCFDANPNPEYILRDAATAMRQAKLQGGDQIAAFKKALHTQAF
EALSLENQLRKNLAQQELFLAFQPIVDLGSGEIAGFEALIRWRLADGTVIPPNRFIPVAEQSGLIQPLGKWVLDSACAALAALRANDAVHMHVNVNVSAR
QLEQHDFVREINELLLIHNLPAQTLRLELTETVLMENAAQVQNFLGQLQEIGIGVAVDDFGTGYSSLSYLHRFSINTLKIDLSFVQSVLTNEHSKAITQA
IIDMAQSLNKTVVAEGIETQEQAALIAAMGCRYAQGFLFSYPLEKEALPQLLDQQP----
>tr|E8V325|E8V325_TERSS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Terriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR
---------------------------MLGQNIWKAFP--GLVGTGFGIAPS-------VVFLSDVTEQRSLDLELRKVEERYRLAARSTTEGVWDRDML
TDQIYYSARWQEIVGLPAVDFIGTSADWE-NRVHPKDLQQAQREM----EQTLEFRTEYRMRHEDRGWIWVRNEGI------------------------
--------------------------------------------------------------------------------------------------II
RDQENRPTRKVGSMKEITSEKSI----------EPLTGLPNRASSVEQIDHRMEMPSKEQATFAVIVVGLDVFNRINDSFGRASGDAILIEIARRLDSTI
QPLSIAGRITGDEFVVLLGRIAGDDAITYANLLQHVLSTPIEHQHQFLTISASIGIAMGDEGYHSAETMLEDAEVAMHQAKRAGKAQCILFGAHMRERTR
RRVELETDLRGAFQRNEFILHYQPKVLLETGKLVGFEALVRWQHPVKGMISPAEFIPYAEETGLIIDIGRWTLRNAIRQAKVWRDSGVADVTMAVNLSTK
QFERPGLIAEIAKKLAEEDFPADCLTLEVTESALMDNIAGAKKSLDGLRSLGVHLDLDDFGTGYSSLSYLNRLPFDSLKIDQSFVHELTDSQESKAIAQS
ILQLGRTLNMTVIAEGIETAEQSLLLMQVGCLYGQGYLFSKPLDAEGIRELLTASP----
>tr|A0A087ME24|A0A087ME24_9PROT Diguanylate cyclase OS=Sulfurospirillum sp. SCADC GN=JU57_02180 PE=4 SV=1
-------------------LWILFSDHLVESLIDNVAYLTLIQTYK-GLF--VTSLLLYGLIRATVTKLEMMQKKLKVHEERLEYVIQGSNLGYWDWDYV
HQHHVVNDKWLSFLGLKREDIENDVTDWE-ERIHPEDRMLTHKAVEHTIKHHQPYVVEFRMRHKDGHWVWIEGSGA------------------------
--------------------------------------------------------------------------------------------------VV
EDKTGAPLRLAGTHRDISDRKNAQRDMLFLALNDTLTKLPNRAYLRQELEKRL---MEE-SSLCFLFLDLDRFKIINDMYGHTIGDKVIQVVAERLKSLL
NHSDFIARVGGDEFVILSNESLH---EALCQKLIAGLDAPIVVADEHFKLSVSIGVACSPHDGKSFEALFKNADTAMYEAKNHPSKHYLFYTSSMTEHLL
NISKFDNDLKHAIENDEFVLHYQPQINLHNNAVIGIEALVRWQHPAQGLLSPYNFIARAEETRLIIPLGLLIFKKALEQMKRWQDEIF-NGIIAINISSV
QIEEEDFIDQIEAIRQKIEVSALSIELEVAESSFMNNPMQSSKTLQKLENLGYKISIDDFGTGYSSLSYLKQLPLHKLKIDRSFISDLPRDRDDQAIAKA
IIVLGKTLELEVLAEGVETEEQKAFLIENGCDSMQGFLFSKPMSAEALKTSLYQN-----
>tr|D1B2Z9|D1B2Z9_SULD5 Diguanylate cyclase OS=Sulfurospirillum deleyianum (strain ATCC 51133 / DSM 6946 / 5175) GN=Sdel_1451 PE=4 SV=1
-------------------LWILFSDSVVGFFIHDNSLISSLQTIK-GLF--ITSLMLYFLIKAKIDEIESIRKNLNEHRQRLEYVIEGANLGYWDWDYV
NHQQWVNDRWLGFLGLMRGDIQDDFKDWA-ERIHPSDKIVADKAIESTIRNNKPYVIEFRMQHKDGHWVWIEGSGA------------------------
--------------------------------------------------------------------------------------------------VV
KEKTGAPLRLAGTHRDISDRKRTQEDMLFLALNDPLTRLPNRAYLRQEFEKRR---LDDNSLMAFLFLDLDYFKNINDMYGHSIGDRVIQIVAKRFASCL
CESDFLARVGGDEFVILTNGHLH---GSLCEDLVRSLVEPIVLEEDSFLLGVSIGVACSPQDGTSFEMLFKNADTAMYEAKSNGKNRYVFYTQDMTDTIV
KSTKLDNEIKRALDNDEFVLYYQPQIDLKTKKVIGIEALIRWNEPSKGILGPNVFIPRAEENRLIIPMGEMVFKKALQQVKQWSEEKL-TGRMAINISGI
QIEEENFVDRLEAIRKEIGVDASLIELEVTESYIMTKAESSILMLQELQDLGFSIAVDDFGTGYSSLSYLKQLPLQKLKIDRSFIKDLPYDYEDRAILRA
IVSLAQGLRLEVLAEGVEEEEQEEFLLKNGCHLAQGFLFAKPMSAEACEEYLRQN-----
>tr|I3XXX5|I3XXX5_SULBS PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Sulfurospirillum barnesii (strain ATCC 700032 / DSM 1
-------------------LWILFSDALLSFFIDDANTLSALQTYK-GLF--ITSLLLYFLIKRKIDEINAIQERLLEHQQRLEYVIEGANLGYWDWDYV
HNSQWVNDKWLFFLGLKREDIEASVTDWS-NRIHPSDKIIAQKAIESTIRHNKPYVIEFRMLHKDGHWVWIEGSGA------------------------
--------------------------------------------------------------------------------------------------VV
KEKTGAPLRLAGTHRDISERKHSQAEMLFLALNDPLTKLPNRIYLREEFEKRC---MNELPSMAFLFLDLDYFKTINDMYGHSVGDKVIKIVAKRFEKCL
QENDFLARVGGDEFVVLTEGHLH---STLCEALVASLLEPIFLEKDVFSLGVSIGVALSPHDGTNFEALFKNADTAMYEAKSRGKNRYVFYTQDMTDTIF
RASKLDTEMKRAIERDEFIVYYQPQIDLQTGGVVGIEALVRWNDPIKGMIPPNAFIPRAEENRMIIPLGEMVMKKALSQLKVWQDEKF-KGRMAINISGI
QMEEENFVEKIETLRQGIGVDASSIELEMTESYIMTKAASSIAMLQELKQLGFSISVDDFGTGYSSLSYLKQLPLDKLKIDRSFIKDLPDDMEDRAILRA
IVSLAQGLGLDVLAEGVEEEEQKLFLLENGCLMAQGFLFAKPMSAQACEEYLRQN-----
>tr|K7T025|K7T025_9HELI Uncharacterized protein OS=Candidatus Sulfuricurvum sp. RIFRC-1 GN=B649_04050 PE=4 SV=1
-----------------------------------------------------------MDSNTLIPAFDCMSDEQLEEFRRLKFAISSSEDGIWEYNIQ
KKTTYVSKRWLEIIGYAENEYHSSIEAWK-SMLHLDDVEKAVGILFNSIANIESAHVRYRIRHKNGHWLWIYDRAK------------------------
--------------------------------------------------------------------------------------------------IL
FDANGDPLIVAGFRTDITHQVELQNKLLHLATHDSLTGLPNRILFNDRLQMALKKNQRHHEKIAVLFIDLDHFKQINDSLGHPMGDKLLIQVALRLQSIL
RECDTIARMGGDEFNILIDSLNQENLTDIVEKLIHAFKEPFSVQGHILYTTLSIGIALSPDDGISTELLLKNADTAMYRAKNEGRNTYRFYANEMGDKAV
ERVMMENSLRIALKENQFAVYYQPQVDLLSHKWVGMEALVRWIHPTLGVVSPASFIPLCEEMGLIQELDFMVLENVVKQHILWQNEGC-APKTAVNFSAK
TLANRNIAKEVWSILEFYHCPYQCIAIEVTESQIMRNPQEAIEILGEFKALGLEISVDDFGTGYSSLSYLKRLPIDKLKIDQSFIHDIPEDEDDMAITKT
IIGLARNLKLDVIAEGVETAEQENFLLQNGCTLAQGYLYDRPLDTQTTTLRLHE------
>tr|A0A069RQX1|A0A069RQX1_CLOLI Diguanylate cyclase OS=[Clostridium] litorale DSM 5388 GN=CLIT_2c01830 PE=4 SV=1
-------------------LVFLIMESIFLIYYYNKFG--YIDTIE-KML-----ALVWFL-GKNYDELQFYSQKASENEKELQQIFDNIDVALWSFDVD
ENVAMVSAGIEKIFGVPRQKFRENPRYWR-SLVHPKD-EKLGQLY------GKSVTTVYRIIKGDGEVCWIKDRST------------------------
--------------------------------------------------------------------------------------------------PN
MDSCGNVIKINGVLSDITDLKSSEEKNEYLAYYDVLTSLPNRNMLYDKFNEILAGYGDSDQNISVIFFDLDFFKMINDTMGHSTGDVVLQNVSRKLNRCL
CEYGFLSRYGGDEFIIMLKDV-GERASKIAECILEEMSHPVKVEDCEIFLSASIGISVYPMHGSDIDTLVKCADTAMHFAKERGRNHYQLYTPDQGKRVG
KKMMLANGLRTALANDEFFLQYQPQFNLETSEIVGVEALIRWRHPEFGLISPAEFIPVAEETGIIVDIGKWVLKTACKQNKEWQEAGP-NVNMAVNVSVK
QFQHRDFIKGIKKVLTETRLDSRYLELEMTESIM-QNSEYLHGVLSELREMGVKLSMDDFGTGYSSLSLLRYLPIDNLKIDKSFIDGIQVDENAVSIIKT
IIDMGMNLNMNIIAEGVENKEQAIFLKKNNCNLAQGYLFSKPLPAGKIRRILEGRV----
>tr|A0A074LMY5|A0A074LMY5_9BACL Uncharacterized protein OS=Tumebacillus flagellatus GN=EL26_15515 PE=4 SV=1
-------------------KEQA----QIEFQFQSEFG--WKQIEVRGM-DV----GFVIV-GRDISVRKEAERRLEESEQRYKSLYEQNIDAVFSYDTE
GKFMGGNPAWEALTGYSEAELTGNGS--T-HHLIPAEDMHLQKAL-------EAQFFEMTFLHKQGYRVHASVTNV------------------------
--------------------------------------------------------------------------------------------------PI
L-VNEQIVGVFGIAKDITKRKRDEQMIYHLAYHDPLTNLPNRRLFLDRLQYALEDARESQQNVAVLMLDLDRFKVVNESLGHAIGDQILQEVAERLHSCI
APEHTVARLGGDEFALLMPSLLDDLAVETAQRILNAFTPPILVAGYEFHITASIGIAIFPEDGCDVNTLLKHADTAMYIAKDQGKNNFQLNRAGKNKQVF
EYMELENDLRKALEREQFVVYYQPQININTGFVIGVEALVRWQHPERGLVSPAQFIPLAEETGLIAQISEWVMREACRQARQWQVEKQ-YFKVSVNLSSS
QFQQMDLVDKVRRILQETELHPQYLDLEITESIAMHNIDFVIAKLKLLELLGVHISIDDFGTGFSSLSYLKKFPIHTLKIDRSFIQDITTDPDDASIVTA
IRWMARSLNLDVVVEGVETHEQLEFLRTIDCDKVQGYFYCKPVPAREFERLVTL-G----
>tr|I5BTG9|I5BTG9_9RHIZ PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase (Fragment) OS=Nitratireductor aquibiodomus RA22 GN=A33O_17619 P
---------------------------------------DNDIV-----QPAIGGGLILIILLIGFTVMQHLFQGLFSDMERQALAISGSGDVVWDWDVS
RDRIITRPDVSRQLGLPSGSLHGPARDWL-STLHTEDRDTFRTTLDVVLEQRGRISQCFRLRGADGHYHWFDLRAR------------------------
--------------------------------------------------------------------------------------------------PV
IGSDGQVIRCVGTMVDVTEQKKAEERLLHDAVHDNLTGLPSRELFLNRLDAIISIARMQQVRPTVFVIDIDRFKQVNEELGISVGDTILLTIARRLHRLL
KPRDSLCRLSGDQFAMILLSEQEARIAAVADAVKQAIRTPVTFARREIVLTSSIGLISWTTTQESAEEMLKDAELAMYQAKRFGGDRIEPFRPAFRSNDN
NRLRMEADLRRAIERSELKLVYQPIIRLEDQTIAGFEALLRWDHPRRGAIPPSDFIPIAESSGLIVQLGLFAMQQAAEDLYRWQKQFPDPLVMSVNLSSR
QLIRRDLVGDVRSVIARSGVSPESFRLELTESVVMDNPEQSAHVLEKLRMIGIGLSLDDFGTGYSSLSYLSSFPFDTIKIDRRFLED-HSA-RGIVMVRS
MVKMAKELELSVVAEGVVDHQDAQQLAEMGCDYAQSFVFGEPEDAETTGKLLFEHT----
>tr|A1SBS3|A1SBS3_SHEAM Signal transduction protein containing a membrane domain, an EAL and a GGDEF domain protein OS=Shewanella amazonensis (strain A
-------------------CKEGVWGMILKVHRPVAKDVAWVLC------PS-GEVLQVITCFTDISALKHAEEALKASEERLNLMLQGANDAAWDWDLR
QHTVYYSPRWWQMIGREPDELEPTEDLWV-KLLHPDDYQKVMDKMNGLFDSPSSFDTEFRLQTKSGSYLPVLCRGV------------------------
--------------------------------------------------------------------------------------------------IL
RGADGTPLRMSGTNMDLTERKESEARIYQLAYYDVLTGLANRTLLMERLKAAIALCERSKQIGALLIIDLDNFKILNDTMGHDVGDALLKMVADRLLQAV
RRCELVARLGGDEFVIVMENLGIERAKSVGQKVRGLLNDPFMLAGKQLRTSPSIGIALFAEGRPGLEELLKQADVAMYQAKEAGKNALRFFDPAMQAAVE
ERVALENDLRNGVLENEFRLFCQPQVDAC-GRLCGGEVLIRWQHPVRGLVMPNQFIPLAEQTDLIIPIGEWVLRKTCETLVEWESHPLAQISLSVNVSVN
QVRDHNFVERVLAIIDDCGANPARIMLELTESLMAENVEEIILKMNALRVRGVRFSVDDFGTGYSSLSYLKRFPLSELKIDQSFVREIALNQHDAVITEI
IITLAKKLGLGVLAEGVETEDQLNFLLAHDCSYFQGYLFGKPCAIELFASSFMDLM----
>tr|A0A023NQW4|A0A023NQW4_9GAMM Diguanylate cyclase OS=Dyella jiangningensis GN=CH75_08515 PE=4 SV=1
-------------------TRAPVSQYVIGLHRSADRQLVWVVC------PN-GEPTEVVVSFTDVTRLKQTERALKHSELRLSLVLRGTNDAAWDWDLV
TGETYYSPRWWEMLGLISDALPATPDLWK-RRVHPDDTQRIGSALEHLLGSIGSYELEFRLRHRQGHYVPVLSRGF------------------------
--------------------------------------------------------------------------------------------------IL
RDAHGKAVRISGANTDLTERKEAEHQIYRLAYYDILTGLPNRRKLMERLDQMLALPVTTHGWGAILFIDVDNFKLLNDSMGHAVGDLLLKQVAQRLESYV
RVHDVLARLGGDEFVVLLGNLGHPPAESMAHEAWSALALPYALDDLSYLCTVSVGIALFDYGERGTEDTLKHADLAICHAKSTGKNKVCVYDKAMEVAMQ
ERLALEHDLRTDFHARRLRMYLQPQVDSD-GRTVSAEALLRWNHATRGDVPPAQFIPLAEATGLILPLGEWVLETACRQLASWAGNPTEGLTLSVNTSVR
QLHDAGFVPSVLDVLRRTGANPSRLVLEVTESLFAEDIETIIERMMLLRERGVRFALDDFGTGYSSLSYLQRMPLDEIKVDRSFIQGIHEGGRGATITRM
IISLAKNLGIKAVAEGVETSEQMDFLYRHGCFHYQGYMCGEAVPPADFGAFLR-------
>tr|A0A085FTC6|A0A085FTC6_9BURK Diguanylate cyclase/phosphodiesterase OS=Massilia sp. LC238 GN=FG94_00924 PE=4 SV=1
-------------------TGRQLSQQVLGIRDTEADPVRWLIC------PE-GVLRRVVVCFTDCTALKEAEQSLQKSEERLRLVLLGSTDAYWDYDLV
ENKIHYSQRWWTMLGYQPGELGCHTDLWL-ELMHPEDRPELLRFWKDLLEGRETYSVEWRLRHHDGHYVPVLSRCF------------------------
--------------------------------------------------------------------------------------------------VT
RDARGRALRVSGTNTDLTERKQAEQRIYELANFDHLTGLPNRRLLVEELDKALARSQRSGCFGAVIFLDLDNFKLLNDTMGHDFGDMLLRQVAERLRHTV
RHCDQLARLGGDEFVLVLEDLAESQAQHVVEKLQSSLAQPYYLDGRLFLSTPSMGVALFDGGATDLDTILKQADLAMYRAKSEGRNTARFFDPGMQASAE
HQVALEHALREGLSAHEFVLYCQPQFSSA-GRLVGAEVLVRWRRADGALLVPNDFIGVAESSGLIVPLGQYVLDESCRALARWRADRLGQLELAVNISAH
QLHSADFTGRVAGALLDTGAPPDKLCLELTESVLAHNVAEVIERMRTLCKQGVHFSLDDFGTGYSSLAYLKRFPLSALKIDRSFVHDVHLDPDAAPIVEA
IIALARKLKLDIVAEGVEHEAQRSFLVGGGCGTLQGYLLGRPVPIWEFERTYSNAG----
>tr|A0A091B7W0|A0A091B7W0_9GAMM Uncharacterized protein OS=Arenimonas metalli CF5-1 GN=N787_01055 PE=4 SV=1
-------------------SRGVVSNLVIGIHRVSDRKLVWLMC------PK-GVPTHVLVTFTDVTELKQAQDALGRSEERLQLVLRGSTDAAWDWDLR
SDELYYSPRWRQMLGYGDGELPVDSALWR-RLCHPRDRGHVGAFLEEVLAGQTSYEVEFRLRHRRGHYVPVLSRGF------------------------
--------------------------------------------------------------------------------------------------VL
RDGKGKAVRISGTNTDLTERKRAQREIQKLAYYDNLTGLPNRQLLMDLLGTAVATSQRTHQRGALMFIDLDDFKTFNDTQGHAAGDALLRMVARRLKQCV
RASDVVARLGGDEFVVVLQGLGEAAAEGVARNIRLALTRPFRVAKRIHHRTLSIGIALFEDVPMAADSVLRHADLAMYQAKAAGRNTLRFFDQEMQRVAD
ERIALESDLRQALALRQLSLHAQPQVDLD-GRVIGAELLMRWQHPTRGWVSPAVFIPVAESTGAILALGRWVIDSACHTLAQWRRDPLSGVALSVNVSVR
QFSDPDFLPQVLAMLERSQVAPGRLKVEITESLFAEDMAMVVDRMEALRDAGVRLSIDDFGTGYSSLGYLSRMPMDELKIDRSFVDQALLSESDAAIVQI
IIALASNLGLAVVAEGVETEVQREFLAERGCRVFQGYLFGRPVPLPAFEAWVRAR-----
>tr|A0A061M590|A0A061M590_9BRAD Hypothetical 91.8 kDa protein y4LL OS=Bradyrhizobium sp. DOA9 GN=BDOA9_0200290 PE=4 SV=1
-------------------SRLNLIATAITRRLDNAQT--WWTGTRDGL-SP----------SRQERLQH-DNDRLRRELKRLSDFLDTSSEI-------
--------VWETDEQ----LMITSGK--S-ELALPAD-IKLAEALLQTLANRPFRGFEICVRKPDEGEVWLEINGN------------------------
--------------------------------------------------------------------------------------------------PT
F-ARGRFTGYRGTCRNVTQRKRHEAQIAFLANHDPLTKLANRRRFHELTERAIAT-LGRHGRIAVLCLDLDGFKNVNDTLGHGVGDVLLLAVADRLRACA
NETDIVARLGGDEFAVLRVDPADDDARRLAQSILASIGEPYLLDDHRVIIGTSIGITIASPSDAKTHEVIKNADVALYQSKADGRGTYRVFHSQMNTRLQ
ERRALEGDLRSALELGQFELYYQPIMNIASKRVVAFEALLRWHHPLKGMISPATFIPLAEETGLIVPIGDWVLRQACSDASSWSND----VRVGVNLSPV
QFRHGSLELSVTRALAAASLHGSRLELEITESILLHDEEMTRDILNRLRVLGVQIAIDDFGTGFSALNYLRTFPLDKIKIDQSFVRDLSDKKNAAAIVRA
ISELGHALDMTVVAEGVETSEQLRILGDQQCTEAQGYFIARPQPAAGLTRLLEA-T----
>tr|A0A081G2V5|A0A081G2V5_9ALTE Diguanylate cyclase OS=Marinobacterium sp. AK27 GN=ADIMK_0812 PE=4 SV=1
------------------------IDEVQSCFVDNSTR--SYQILHQGQGPVATTYRVLML-LREYVPFHHFDESSASREQMFCNLVENSPDTIARYDRE
CRRCYANPAFVRQSGVALSRLIGFTP--S-E--VPGGDMKA----VRSVLEGAEQQYELSWLSEEGVERCSLIRLS------------------------
--------------------------------------------------------------------------------------------------PE
YDAAGQVSSVLAVGRDISEVDQYRRRVHVLANYDAVTGLPNREMFYSRLRQEIATAREAHGSVGLIILDFDHFKVINDSLGHVAGDCLLREASERLKHCL
QHDEFVARLGGDEFAIILPDCHEDRLGHVPQLLIEAFGEPFELHEREIFVTASIGISRYPQDSRQIDDLIKYADSAMYSAKSRGRSEIAYYEKGLTTGVT
ERMMLEGELRKALERNELELYFQPKIELVHQIIVGSEALLRWNHPQLGLLTPDRFITLAEETGLIIEIGDWVFRRACEVAVEWNRDEK-LHTVAINLSPR
QFVGKDLVSTVCEILEQTGCSPRWIEVEITESLLLDDQPSTRRALNKLSELGIRIAIDDFGTGYSALNYLTRFPIHILKIDRSFIERITTDRNCEKLVKA
IINLARSLRMTLVAEGVETKAQALFLENLGCHQVQGYLYARPGPKSEIEGSLLNLA----
>tr|J8VVD9|J8VVD9_9SPHN Putative signal transduction protein OS=Sphingomonas sp. LH128 GN=LH128_02619 PE=4 SV=1
-------------------GWLVLLFGAMPVTLQF-------LISGDGLT----FTLAAFVILRSLAASHATQSALQSSEERYRLASLAANDIIWDVSLD
EGRINLSSAGIAILGYPDAPEGTSAAWWV-ERLHPDDRARVLLQIEDLDDVKTFWTEQFRFLSGSGAYLHLILKAY------------------------
--------------------------------------------------------------------------------------------------VV
RDNEGRPIRVVGSLQDVTVQKHYEEGLRWAALHDSLTRLPNREMFAGSLENALEEAAEQQSAVGLIVFDLDLFKAVNDSLGHHGGDALLSEVAARLTRAV
PEPGTVARLGGDEFGIILPHWSAEETEKAVAELLAPIGHPMSYEGRQIDVSLSAGVAVAFQDGTNSEELLRSADLALYDAKREGAGRICVFRGELRTAAE
REKKMLADARSALHDDRIVPFYQPKVCLRTGACVGFEALLRWNDER-GLQSPGAIAAALGDADLSVQITERMLDRVIADMRSWVTSG--FGRIAINGSAG
DFRRGDFAQRILDRLRRAELRPWLLELEVTESVFLGQAEKVSEALNILSQEGVTVALDDFGTGYASLTHLKQFPVDVIKIDRSFVSRLGMAEQDAAIVGA
VLDLARNLGIHTVAEGIETPQQLKHLVVKQCDFGQGYFFGRPMAAAQVKQVIADWD----
>tr|E3PWT0|E3PWT0_CLOSD Str. DSM 519 chromosome, complete genome OS=Clostridium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIB 10654) GN=CL
--------------------------------------------------------------------------TIKEKSPWKTIVIYTILGFLWILFSD
-----------RFVD-----LFADS---H-----ETYKL---------------------MQSYKG-VFYVVVTAVILYLIKDY-SKIMKLTNDVSEKNE
ELVSFNIQDDIFQNSNTSIVTWGLDGEVLDINNHFTELMGYDRQDIIGKKWYILLPEQKY-KYY-ELASKLESDRKVQYENKAVAKDGRIFDMLWNNAMI
YNPQNDLTIVVSFGIDLTMQKQNERRIYELAYNDKLTGFKNLIAFENDINSKINK----KTSFTLYYLDMDNFKHLNEIHGHKCGDMFLKDYASRLLTIF
DR-TNVYRWCGDEFVIIEEDTNDINITKRIDEIALLTKNIWKYKNVEYYPSVSIGITKFPEDAENLEGLKKNMDMALYKAKSSGKSLAVAYHSDFQKDIE
KKLDLENTITQALINESFRLVFQPIYSIKTGRIISIEALIRCKSL---NINIGEMINIAEESGQILQIDRWVIKKAFEIMKNELDK--YDILLSINLSAK
SIASPDLIDYLSNITKEYNINPNKIEFELTEHSLIFDIDWSKEVIGKLKHLGFGIALDDFGTRYSSLNYLSTIPFDSLKIDKSYIDKIVDTDKSRVIVEQ
IIDLSHNLGLTTVAEGIEENEQLDILKKLDCDYGQGYLLDKPLELEDLIIKIN-------
>tr|Q1JVN0|Q1JVN0_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_0152 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------YIGAPVWRV------------------------------------------------------VY-GSIAGGL--VGIWSRRLRQALV
KQVKL---LDLFENASDLIQSVRLDGSILYVNRAWKETLGYLDHDIPSLNIFVISSARPICNRVISL---LDGAELGPIEVTFQCKDGRAVLLEGNSL--
RQDEGQPHSVRGIFRNISERKQAEQKIHQLAYYDTLTGLPNRVLLQDRLIHAIADARRFSHYLAVMFIDLDQFKKVNDTLGHSVGDLLLKDAARRLRSCL
RDNDTAARLGGDEFVVILSGFKQISLPHIARKVLDVLSQPYFLAERELVVSASLGISVYPQDGDNAELLMRNADMAMYAAKYDHGNGYCFFSEEMNKNAT
RQLELEEQLRHALIDQQFEVYFQPQFDWSRQKLTGVEALVRWNRAQGEVVPPEMFIPVVESTGQIVALGEWVLRQACLQIQQLQC-QNVPLQLSVNLSGR
QFDDLSLIYKVKKILQETNFPPEQLELEITETILMENADSARKTLGQLSQQGIRLAIDDFGTGYSSLNYLNTFPVDRLKIDKSFLVNVMHDDNHAAIVAT
IISMADTLGLSVIAEGVETMEQVSFLSDLGCQAMQGFIFSEPLPREELEEFVQ-------
>tr|E4TZP9|E4TZP9_SULKY Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sulfuricurvum kujiense (strain ATCC BAA-921 / DSM 16994 / JCM 1
--------------------------------------------------------------------------QLARQDALLRTIVNSSPDAIFVKDLE
GKYLLFGMSPEKVIGNTDSLIFSPE---T-----ASDRS---------------------IISSEGKEKSFWVTKGPLFNEEGKIFGLFGISRDITEETV
SQIRL---TSLINSTPDAIVIKGLDRRYIVFNEGASKFSGIKSSDAVGKTADEIFPPKT-AGIINAIDDDLLKNQSFIHEETLIMPNGKMYI--YTKGLL
KTENGDIFGIFGIYRDITNEKHHEQRFDFMAHHDSLTGLPNRLSLMEYLKIKC--S--QNSPFAFLFLDLDGFKEVNDSYGHRFGDKLLIRIAEVLETIT
PSNSKIIRTGGDEFVVILECNEEENIDLMMQNLVLALRHPFNIDNVDVYITASVGIAMYPSDADNSEDLFQKADAAMYNAKKSGRNTYSFYESKFTETSI
QRTTISTNLKKAIQSGELSLHYQPQVDQFTEEIIGLEALCRWFTPE-GAVSPGVFIPIAEESGLILEIGEFVLREGCLKTSKWDKAGLLNGRVAINISAR
QLSHVDFIDTLDSIVSETQCDPKLIELEITESSILNDPEYVIALLHTLKKRGFFISIDDFGTGYSSLSYLKNLPIDKLKIDQSFIRNITDNRKNQTIVKT
IIALAKGLDIKVLAEGVETSEELEFLRLNQIDSIQGYYFYKPMDSQSVESLFK-------
>tr|A6W3B3|A6W3B3_MARMS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Marinomonas sp. (strain MWYL1) GN=Mmwyl1_4297 PE=4 SV=1
--------------------------------------------------------------------------HAENYKNQLTSSLDALSDPMWIKDKD
QTYIYCGLSKLEIIGYKDEEIQSQH---V-----QLIPA---------------------ITSPCGNVYFQVSTERI-YDISDQLFSSVGYAQKITPFKE
RESEL---NEALKLTKVGIWEWNVDKDIWFATPSYFTMLGYAPVEGMADRKAKIHPERQHVSVNNILT-SKSESNYYKYQARIRHIDGNYRWIGVRIVTE
FDQEDKPARMLGVRIDIDEIQKAHDQVEWLAHHDSLTKLPNRVALNKTFHKII--K--PNTKIALLFIDLDHFKNVNDTLGHSIGDQLLLTVADRMRTLV
NNIGYVARQGGDEFIILLPADNEE-LIEKTCAIKEALSARYNIDQHQFFITPSIGVSLYPRNGEDFDTLYQRADAAMYHAKHTGRNRYAFFTEEMQAIST
RALTLGNALHDAIERQEFSLHYQPQISLITGKIIGAEALIRWHSLELGHVSPGEFIPLAEENGQILAIGEWVLRETARQLKQWLEEGITPVRIAVNLSYA
QFQVNDLPSIVEAILNEYAVPAQYLELELTERIATKDPEHTITILESFQQLGIHTSIDDFGTGYSSLSYLQRFPVYKLKIDQSFVRNMTTNTNDQVIVGT
IILLAQQLGMTTIAEGVETKAQLEMLYNIGCDDIQGYYISRPIPAEEFKIGFL-------
>tr|F6CUI4|F6CUI4_MARPP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Marinomonas posidonica (strain CECT 7376 / NCIMB 14433 / IVIA-P
--------------------------------------------------------------------------SLQKFTKQVTASLDAIPDPVWIKDQK
QVYIYCGLPKNQLLGFTDEDIQTRQ---H-----A-PID---------------------ITSADGTMFFQIGIAPS-FDNKAKLVSTLGYAKRLTEYKE
RESQL---NEALKLTKVGIWEWDVTNDIWFATPSYFIMLGYSPVEGAASRKQKVHPDRAAVTIQNILT-NKSPSNYYKYQARIRHKNGEYRWIGVRIVTE
FDSKGNPSRMLGVRIDIDEIRKANDQVEWLAHHDSLTKLPNRESLNQAFHQLI--K--TNTKLALLFIDLDHFKKINDTLGHVIGDQLLQNVADRMRHLV
KDIRHIARQGGDEFMILLPAENMS-IESKTIEIKNALSERYYIDQHQFFITPSIGVSFYPENSENFETLYKQADTAMYHAKNAGRNRYAFFNQEMQAAST
RSLMLSNALHDALLQNEFSLHFQPQVSLSTTEVIGAEALIRWHSKSLGHVSPGEFIPLAEESGQILSIGEWVLRETVRQIRTWLNNDIKPVRIAVNLSYA
QFQTNDLPILIADILKEFNVSSEYLELELTERTAAIDPEHTVATLESLQQIGTHTSMDDFGTGYSSLSYLQRFPIYKLKIDQSFVRNMANNYNDRIIVGT
IILLAQQLGMRTIAEGVETEEQLDLLKTIGCDDAQGYYISRPIPAERFELEFL-------
>tr|B5EBL6|B5EBL6_GEOBB Sensor diguanylate cyclase/phosphodiesterase, PAS, PAS and PAS domain-containing OS=Geobacter bemidjiensis (strain Bem / ATCC B
--------------------------------------------------------------------------ALQRSEARYRRLFETAKDGIMIVEAD
SGAIAEGCKREALLGKTVWELGFFA---R-------DKA---------------------MQQ-----------LLATVGGRDIPVEVVSNIRDISIRKN
AEQALRF----------------EEGTSVYHSPKCFDITGYTPDEYY-----MIHEERNLVEFLNGIFAGLD-H-EPIR-HRIIHKDGSVRWIVNAQRQR
RGDRLSITRLDGFILDITDIKRAEENIFFLAHHDPLTKLPNRSTLYERMEQVICAAQKSSRNVALLFLDIDGFKQINDSMGHDVGDRLLQSVAKRLSDCT
RSCDVVSRLGGDEFVVMLWDCGETETV-----VAKVINAGFPVLGSNVTVTPSIGISVFPDDGRDYLTLLKHADIAMYHAKKSGGNNFQFFTHRLNEIAH
ERFVLEAELRRALDREEFVLYYQPKVDLSTGRFSGMEALIRWQHPAHGLMLPESFIRIAEESGLLTQISKWIIPTVCRQIQQWQQQGINSVSAAVNLSAS
FFQHPDFEETIEDSLLQTGIAPECLELELTEATIMSDPQRVLGSMAAMKALGLQLSIDDFGTGYSSLSYLKKLPVDKLKIDQSFIHNIARDADNAAVVRA
VISIGRSMQLRVIAEGVENASQLAWLQAEGSEEAQGYYFSRPLPVAKMTALLK-------
>tr|A1SWE1|A1SWE1_PSYIN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Psychromonas ingrahamii (strain 37) GN=Ping_2051 PE=4 SV=1
--------------------------------------------------------------------------AEREKNKLLLNIVNSIPEPIMAKNWE
GNFIFASTSPEEMIGKEDSFFTGNK---E-----QGNQS---------------------IMRTAEIRHYHSLKIPF-KNNNDE-LNIVMFAKDITEITA
LKNTA---GHVLEVSGEGMWDWNIQTNEVFQNQKWADITGVKHSKRSFSEFQCLVEEKKYVTSLQAL---IEKKIPYDIEYRFRRPDGKVIWIWDRQVLE
YDDQGKPKLLVGIMQDITEKKFNQSEIELMAFYDTLTMLPNRALLNDRLNLAIEHSKRFEKYGAVLFLDLDNFKILNDSYGHQAGDDLLVIVAQRIQSVI
RKDDTVARFGGDEFVIVLNELDSEPAQRLAQSICHSIKQKINIADIDYFITASVGITIFYGQSKVPSELLQLADLALYQAKKNGRDDSAMFDPVMQEKLD
YSTCLDKELRQSLKQKDFVLYYQPQYD-AKQNLVSAEALIRWNHPELGLVNPGDFIKVAEESNLILPIGDWVLSEACQQLKKWQSDPYQHLSLSVNISAK
QIWQKDFVAGIKRIVSDSDINVSKLKLEITESILLRDINGTAEKLNDLVAFGLTFSLDDFGTGYSSLGYLKNLPIDELKIDQSFIRDLFDNKMDLIMVKS
IIDLGKNFGINVVAEGVETEAHFEILKEFGCKIYQGYYFSRPVPVSEFVTLI--------
>tr|N4WNQ0|N4WNQ0_9BACI PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Gracilibacillus halophilus YIM-C55.5 GN=J416_12859 PE=4 SV=1
--------------------------------------------------------------------------VLAYTNQQLESLFHFNPDLIFMLNTE
GFFTNIQYSKQELITKRYIDLIHDT---D-----ISFQV---------------------LKNKANEIIEMDVTAVP-VIIDEEITGVIGIARDITEQKQ
VKQQL---RSLFENNIDAVLTLDLEGNFLYLNQATEALMGYKAEELLHTPFLHIVPEQSYTQYR-KV---LRG-HPIQYKTCMFHKNKQRVYLHVTIP--
IVINRKVTGVHCIGKDITENQHLEDQLNYMAYHDYLTELPNQHHFQFQLQALIEQSKLNDNQFALFFLDLDRFKNVNDSLGHEYGDLLLKKVANRLQQQL
TATETVFRFGGDEFIILQEETNDE-TNLLAQSLMDQLSQPYEIRGLDIVTTVSIGISMFPHDGDSRQSLVKKADNAMYHAKRSGKNMYQMYQESLGYQIY
GNIELETLLRKALERNEFQLFYQPKVSGNTEEVIGVEALIRWNNREHGLISPGEFIRLAEESGLIIPIGKWVLYEACRQLKEWHANGYSSITVSVNLSMR
QFHQSDLVTTVEQIIHETQIDPMYVELEITETMTM-DAEAALSILRDLKQIGVKISMDDFGTGYSSLSHLKRFPIDYLKIDQSFIRDIIIDKDNQDIVDT
IIMLGHNLDMQIVAEGVETKEHVTYLRQHHCDILQGYYFSKPLTHEAFYEWLT-------
>tr|W4QEL3|W4QEL3_9BACI Diguanylate cyclase/phosphodiesterase OS=Bacillus hemicellulosilyticus JCM 9152 GN=JCM9152_1783 PE=4 SV=1
--------------------------------------------------------------------------LLDKVIKQYDSLFYFHPDFVFSLDEK
GAITNLKYELSELIGKSFEIMIPHD---E-----QEFKN---------------------IQGKLQQRIDLNVTSVP-IILHDQVIGIIGIARNVTLQNK
TKRLL---RSLFEFNVDAVLTLDLEGRFLEVNQATERLTGYHADELLEKSFLLIVPERERTHFQ-KA---LEG-NPQQYETSMYNKNDEKMYFHITIP--
IFIDRILTGIHCIGKDITEKKRIEEKMNYLAFHDSLTELPNQRLFRFEGNQALKEAKEKRGMIAVCFLDLDRFKFINDYLGHEIGDLLLQKVANRLEKVL
KDKGRAFRYGGDEFILLLKNTSEV-VLSTAKNVIENISKPFNLNGFEAVVTASMGISLYPHHGETPFTLIKKADNAMYHAKRQGKNNFQIYGSYVRGMTN
GNLKLETLMHKALEQQELLLLYQPQMDAKTNTIYGVEGLIRWNNDELGMVSPQEFIPVAEETGLIVPIGEWVIRTACKQNKEWQQKGLSPIVVSVNLSIR
QFYQSDLIEKIDAILKETQLDPCFLELEITESMAM-HADTAIVILTELKKLGVKIAIDDFGTGYSSLNYLKRFPIDHLKVDRSFVKDIQVDD-DRDIITT
IIALGHNLKMKVIAEGVETKEQVAFLKKAKCDILQGYYYSKPLDSKMIEEMLL-------
>tr|D6XZ65|D6XZ65_BACIE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS
--------------------------------------------------------------------------LHERTSKEFESLYLHNPDLIFSTDPL
GNFTNMEYSKQELMKLPYDEILDVA---H-----INFKA---------------------LKGKSGRPVDLNITSLP-ILVEDQVEGVISIARDITAQNI
TENLL---KSIFQYNVDAVTTLNTAGELYYSNPAAEQLFGCDRSELIKEPFSFIIAEREPFKMT-MT---LEG-TPHQHETAITNTRGEKRYVHLTIP--
TFINKEVTGVHCIAKDITESKQSEEKISFLAYHDTLTTLPNQYKFQQDLNTLIARSSIKPKPFSIFTIDLDRFKFINDYLGYDLGNELLTKVGTRISELL
SEDAKLYRYGGDEFTIIHLDATPE-SLQLGNKIASAISMAFDISGFDAFITVSIGISHHPDHGKDLNTLIKKSDNAMYFAKKMGRNNVQMFNEEINTLST
KNLKLESLLYKALERDEFLLHYQPQYDAKTNRISGVEALIRWDNEELGMISPADFIPLAEETGLIVPIGEWVMRTACHQNKAWQDEGLPPMVMSVNLSIR
QFYQPDLPQVIGKILEESGMAPELLELEITESMAM-HADSAISILKQLKQLGVRIAIDDFGTGFSSLNHLKKFPLDHLKIDRSFVDDICLGSEEQDIVKT
IIMLAHNLNLRVVAEGVENDLQQQFLKDHRCDVFQGFHFSKPVIRDAIPELLR-------
>tr|K2GR31|K2GR31_9BACI PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Salimicrobium sp. MJ3 GN=MJ3_00050 PE=4 SV=1
--------------------------------------------------------------------------RLKHKDQQFKSLYLYNPDTIFSLDMN
GRYTNIGYAPEKINGSSYLEFLTKE---A-----GEFKV---------------------TNGRDEARHIMDVTAVP-LIIDNVITGVIGIARDMTVKKA
TERLL---RSLFDYNTDAVMTFDTDGTFTHANASTEKLTGMSIEQLRGKSFLFISEEREETHFF-TS---LQG-QPHQYETQLTMSEGEKLYLHIAVP--
IYIDGSITGIHCVAKNVTELKKLNTKMNHLAYHDTLTGLPNQRYFHETIEQK---LA-SGENFALFFLDLDRFKFINDYMGHHMGDELLKQVSRRLLRLV
GTRGNVFRYGGDEFLIILPEVDTE-AGEIAADITSEMERSYDLNGYEALVTVSIGISMSPEHSNTTAALIRQADNAMYHAKNLGKNTWQVYNSQVQKR-K
TDLKTESHLYKALANREFFLVYQPQFEKDSSHLIGIEALLRWRNKDLGLVSPSEFITIAEETGLIVPIGEWAIREACQQAKAWQDEGYPPVKISVNLSMR
QFYHNDLVEMVAQILQETGLPAKYLELEITESMAI-HAEEATDILNRLSGLGVKISIDDFGTGYSSLSYLKRFPIHQLKIDKSFIKDIGVDRENNDIITT
IISLADSLNLEVIAEGVETASQLDFLRRNGCDKYQGYYFAKPMKPEQIVSHFN-------
>tr|T0Y1Z2|T0Y1Z2_9ZZZZ Sensory box/GGDEF family protein OS=mine drainage metagenome GN=B1B_15110 PE=4 SV=1
--------------------------------------------------------------------------TSSLDQSYLHALFEHSPEAIVVLDRE
GKILSAGYATEEILGSDIDHLVVPE---R-----LR------------------------LNLKDGTTLPVSILAAP-ILHEGNLVAFYSIYRDLSALRD
AEWRL---DAILSQAPIVLFTLDTDAVFTFCAGKAMESAGLTVQESIGQSAYLFKGIEMPA-----T---LKGE----RVSIMVTFRGL--TYEVQSP-I
LDADGAVDGVLGLAHDVTEMQLARKQLEFMAHHDILTGLPNRALFHDRVQEALHRAKRRNTKVALLFLDLDRFKQVNDTLGHQTGDRLLKWVAHTARGAV
RDMDTVARFGGDEFAVLVEDIDTTLAAAVAQRLLDGLNQPYEDAGHPITTGASLGISLYPDDGLDAETLLKQADIAMYRAKNGGRGYYEFFSKDMSEAAT
AIFTKTAWMRHALEHDGFVLHYQPTINLQDGCMTGVEALIRLRQPDGILMPPLEFIALAEETGLIIPIGRWVVHEACRQWKAWQAEHL-NLRMAINLSAR
EFHDDAFVRTIGDTLEAHAVPTERFMVEITESMMFPDLLKAHAMLGELRDMKIAVAIDDFGTGYSSLAHLKDFPANYIKIDQSFVAGVPADEKTCGIVRT
IVAMAKNLNLGVIAEGVETEAQRSYLQALDCDEAQGFLFGAPTEAQILSRRLD-------
>tr|A8FRI0|A8FRI0_SHESH Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Shewanella sediminis (strain HAW-EB3) GN=Ssed_0842 PE=4
--------------------------------------------------------------------------VSNGDVIDLQLFIDSLKEHVWMKDIE
GRYVIFGKTREEIMNKTDEELFVAD---L-----AEDEA---------------------INKAEIDRYWLETAKVPVVTDDGCLKGVIGLSRNISQHKA
VQE-----GRVFENSVEGVMITDRDGKIIETYGAFSEITGYSREEVLGKNPSMFSSGRHDKAFYDDLWTGLLHKGRWHGEIWNRRKNGAIFP--QTLSSM
LGDDGLVRYFVAVFTDISAQKKNEEQLAHLAYHDPLTNLPNRMTLTAQIEQELRHAQYQGSQLAIVFIDVDLFKQINDSFGHLMGDEILVELANRLTAQK
GAEDTLARIGGDEFVVLFPGGGGSELTLALSKLREAFEQPFSVENDQVRLTASMGVSVYPHDGKDGYTLLRNADAAKHRAKQDSRNSYAFYTESLTLESR
EHLKLQSALHMALEEGNFHLVYQPKLNFNSLKTVGFEALLRWRDPVLGDISPGVFIPIAEKIGLINAIGSWVLRAACLQGVKWIEQGKTFGRIAVNIAGQ
QIKRSSFVEEVKQILNETGFPAQSLELEVTESFMMSDPEVAIRDLRVLGDLGIELSVDDFGTGYSSLNYLKKLPIHKLKIDQSFVRDIPSDANNTAIAKA
VIALGHALNLQVIAEGVETEEQADFLRESGCDEVQGYLYSRPQLPEALQQFLY-------
>tr|A9CVJ4|A9CVJ4_9GAMM Sensory box protein OS=Shewanella benthica KT99 GN=KT99_06022 PE=4 SV=1
--------------------------------------------------------------------------IASLEDVSLQLFIDSLKEHIWIKDTS
GRYMVCGKTREEIINKTDEEIFVAD---L-----ANDDA---------------------IHKEDVDKYWLETSKVPLLTEDGELLGVVGVARNISQHKA
VQE-----GRIFENSVEGVLITDRKGEILETYGAFSEITGYSKDEVVGKNPRMFSSGRHDKAFFTELWSRLIHKGKWHGEIWNRRKNGAVFP--QTVSSV
SGEDSEVRYFVAVFSDITLQKKSEAELAHQAYHDPLTQLPNRMALISLIEQDIRHAEVQQGQLATVFIDVDFFKHINDSFGHLAGDKILVELAGRLTSLK
GAEDTLARIGGDEFVVLLPQVEGNELTLALSKLRKAFEQPFIIDNEPIRLTASMGVSVFPHDGKDSYTLLRNADSAKHRAKLDGRNSYAFYTESLTQESR
EHLKLQSALHAALDKQNFHLVYQPKLDFVTMETTGFEALLRWCDPVLGNVSPAKFIPIAEKIGLINEIGLWVLKQACQQGVKWISQGKKFGRIAVNVAGQ
QLQRTSFVDEVKQVLQETGFPASALELEVTESFMMSDPEVVIRDLQRLGEMGIELSIDDFGTGYSSLSYLKKLPIHKLKLDQSFVKDLPLDLDNAAIAKA
VIALGQALNLKVIAEGVENEAQATFLRDNGCDEAQGYLYSKPMLPEALNDFLY-------
>tr|A0A0C3LR72|A0A0C3LR72_9GAMM Contig_29, whole genome shotgun sequence OS=Shewanella sp. cp20 GN=DB48_10190 PE=4 SV=1
--------------------------------------------------------------------------PSETSNVDLQLFIDSLPEHVWMKDVA
GRYVLIGRTREELLNRTDDEIFSPE---V-----AEDES---------------------IVRVDQSSSWLETTKVPVVSSDGTLEGVIGISRNITSHKA
AQE-----ANIFENSVEGVVITDANGNIVEVHGAFTEITGYSREEVLGENPRILNSGRHDKAFFERLWQSLLTNGKWHGEIWNRRKSGAIYP--ETISSM
YGDDHQVRYFVAVFADISAQKQSEKEMARLVYHDPLTKLPNRLMLSANLEQELRHAAREETQLALIFIDVDLFKHINDSYGHVTGDAILMEVSRRLKQKL
GEEATLARLGSDEFIAVLPHVESDDVSLMVSRLREAFDAPFLLDEGSVRLTASMGVAIYPGDGDSGDTLLRNADTAMHRAKANGRNNYAFYTQSLTLASV
EHLKLQSALHDAISKDAFYLVYQPKLGLGTGQCVGFEALLRWDDPQLGVISPAVFIPVAENIGLINEIGLWVLKQAAAQGACWLAEGKTFGRISVNVAGP
QLQQKQFFTQVKQVLDETGLPPEYLELEVTESCMMSDPLAVIEVLKQLGELGVELSVDDFGTGYSSLNYLKRLPIHKLKIDQSFIRDIPRDSNNTAIAKA
VIALGHALNLCIIAEGVETPEQAAFLEAAGCDQAQGYLYSRPRVVDELDEFLG-------
>tr|A9KTG3|A9KTG3_SHEB9 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella baltica (strain OS195) GN=Sbal195_1329 PE=4 SV=1
--------------------------------------------------------------------------PSCVDTVDLQTFIDSFEEHIWMKNAA
GIYTLCEMPRSEIVGKSDVELFGAE---I-----ANDLA---------------------IESEAKNHLWLETLKLPTLNTQGEFVGVIGMTRNISKHKA
VEE-----TNVFKNSVEGVVVTDRHGNITDVNGAFFEITGYVREELLGQNPRIFSSGRHDKAFFDKLWNALLANGKWNGEIWNRRKNGTIFP--QTISTI
YDEVGDVRYFVAVFADISAQKENEAQLTHLAYFDPLTHLPNRMKFMMQLKQEVRQAKRLNLQLATVMIDVDLFKHINDSFGHSIGDEMLVELAKRLRSQV
GDQDVLSRIGGDEFVALISGIDNNEATVAINQLRQVFEQPFIVTGDHLRLTASMGVSLYPNDGTDADTLLRNADAAMYRAKNDGRNNYAFYTESLTQQSF
EHLKLQSALYGAIEQNALYLMYQPKLDLVSRKTVGFEALLRWHDPQLGLISPAVFIPVAEKIGLIHEIGLWVLETACRQGMRWLSEGKHFGRIAVNVAGQ
QLQRSSFVDDVKRVLAETGLPAKHLELEVTESVMMQNPDLAIRDLKLLGDLGIELSVDDFGTGYSSLNYLKKLPIHKLKIDQSFVRDIPFDTNNTAIAKA
VIALGHALKLDIIAEGVETKEQADFLQQNQCDQAQGYLFSRPQLPEDLDAFLS-------
>tr|F7RM87|F7RM87_9GAMM Sensory box protein OS=Shewanella sp. HN-41 GN=SOHN41_01475 PE=4 SV=1
--------------------------------------------------------------------------QSNLQVLDLQTFIDSFEEHIWVKNVD
GIYTSCEMPRNEIVGKTDVELFGKD---I-----ADDLA---------------------IETEQTKHLWLETLKMPAFTADGQLAGVIGMTRNISKHKE
VEE-----TNVFKNSVEGVVVTDRHGNITDVNGAFYEITGYSREELLGQNPRLFNSERHDKAFFDAMWNALLETGKWNGEIWNRRKNGTIFP--QTISTI
YDDVGDIRYFVAVFSDISAQKQSEAQLAHLAYFDPLTHLPNRMKLMMQLKQEVRHAKRLNAQLATVIIDVDLFKHINDSFGHSIGDEMLVELAKRLRSKV
GDQDVLSRIGGDEFVALISGIQNYEATHAVNQLREVFEQPFVVTGDHLRLTASMGVSLYPNDGTDADTLLRNADAAMYRAKNYGRNDFAFYTESLTKQSF
EHLKLQNALYGAIAQNALYLMYQPKLDLSTRKTVGFEALLRWNDPQLGQISPAVFIPVAEKIGLIHDIGLWVLETACRQGVTWLAEGRHFGRIAVNVAGQ
QLQRSTFVDDVKRVLEKTGLPAKYLELEVTESVMMQNPDLAIRDLKLLGDLGIELSVDDFGTGYSSLNYLNKLPIHKLKIDQSFVRDIPFDTNNTAIAKA
VIALGHALKLEIIAEGVETEEQADFLRQNRCDQAQGYLFSRPQLPSELEAFFA-------
>tr|B8CU86|B8CU86_SHEPW PAS:GGDEF domain protein OS=Shewanella piezotolerans (strain WP3 / JCM 13877) GN=swp_4291 PE=4 SV=1
--------------------------------------------------------------------------ADKPLNVSLQQFIDAMKEHVWMKDAE
GRYIIVELSREQILEHTDEELFTPQ---L-----AQDES---------------------ITKIGNVESWLETTKVPVVSEAGELSGIIGISRNISTHKA
AQD-----SRVFENSVEGVLITDVDGIIIDAHGAYTEITGFEKSELIGQNPRVFNSGRHDKAFFESLWQSLLGSGKWHGEIWNRRKNGAVFP--QTISAV
YGDEHQIRYFVAVFADLSTQKKNEAELAHLAFHDPLTKLPNRMAVTSRLEQEIRLANRSEYQLGVIYIDVDLFKQVNESFGHVIGDEVLVELSQRLTLAI
GSLATIARLGGDEFAVILPNIESSDLLLRLSKLPQIFERPFMLEHAPVRLTASMGVALYPQDGRDSSTLLVNADAAMHRAKQDGRNNYAFYTQSLTYESV
AHLKLQSALHDALAQEAFYLVYQPKVDCKTKALSGFEALLRWNDPLLGSISPAIFIPVAEKIGLIQEIGRWVLQQACEQGVSWLAEGKDFGRIAVNVAGP
QLQRRTFVNEVADVLKATGLPANRLELEVTESCMMSDPESVGRDLILLADMGIVLSIDDFGTGYSSLNYLKKLPINKLKIDQGFVRDIPEDANNTAIAKA
VIALGRSLNLKVIAEGVETPEQAMFFADNGCDEAQGYLFSKPKAASELEHFFE-------
>tr|V1DHV2|V1DHV2_9GAMM Diguanylate cyclase phosphodiesterase with pas pac sensor OS=Shewanella decolorationis S12 GN=SHD_1477 PE=4 SV=1
--------------------------------------------------------------------------SKSMDVISLQTFIDSFEEHIWVKNAE
GVYTICELPSREIVGKTDEELFGKD---I-----AEDRA---------------------IDASQNKHLWLETLKVPALTPEGTLAGVIGMTRNISKHKE
VEE-----TNVFKHSLEGVVVTDRHGNITDVNGAFYEITGYSREELLGQNPRLFNSGRHEKVFFETMWNNLLETGKWNGEIWNRRKDGTIFP--QTISTI
FDEVGEIRYFVAVFADISAQKQSEAKLAHLAYFDPLTHLPNRMKLMMQLKQEIKHAKRLNAQLATVFIDVDLFKHINDSFGHSIGDEMLVELAKRLRSQL
REQDVLSRIGGDEFVALVSGIQQLEANLVIEQLRQVFEQPFVVTGDHLRLTASMGVSIYPSDGANADTLLRNADAAMYRAKSEGRNNYAFYTESLTKESI
EHLKLQSALYGALEQNALYLMYQPKLDLVSRKTIGVEALLRWNDPVLGQISPGVFIPVAEKIGLIYDIGLWVLETACLQGVRWLAEGKPFGRIAVNVAGQ
QLQRSSFVEDVKRILAETGLPATCLELEVTESVMMHNPDTAIRDLKLLGDLGIELSVDDFGTGYSSLNYLKKLPIHKLKIDQSFVRDIPFDTNNTAIAKA
VIALGHALKLEIVAEGVETQEQAEFLTQNLCDQAQGYLFSRPLLPADVEAFLA-------
>tr|B0TTP3|B0TTP3_SHEHH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella halifaxensis (strain HAW-EB4) GN=Shal_0811 PE=4 SV=1
--------------------------------------------------------------------------GHQASPVGLQTFIDCMKEHVWMKDTS
GRYMMVNRSREQILNFTDDELFEPR---L-----AKDES---------------------IRKIGDVDSWLETTKVPIMDDDGELTGVLGISRNISSHKA
AKD-----SRVFENSVEGVIITDVDGAVIDAHGAYKEITGYEKEELLGKNPRVFNSGRHDKVFFTKLWSDLLTKGKWHGEIWNRRKNGAIFP--QNISAV
YDDEHQIRYFVAVFNDISAQKQSEAELARVAFHDPLTKLPNRMALNTGLEQELKQASHSNTRLGLVYIDVDLFKQINESYGHPMGDEVLLELSRRFNFGL
DNLATVARLGSDEFAVILPNIDSNDLLLSINKLRKMFDQPFLLEHGQARLTASMGVAIYPDDAQDSSGLLVNAEVAMHRVKQDGRNSYAFYTESLTQESV
AKLKLQSALHDALELNAFHLEYQPKISFRTGDVVGFEALLRWVDPVLGSISPDIFIPLAEKIGLIQDIGRWVLKRACEQGQRWRKQGVSFGRIAVNVAGQ
QIQRSSFVDEVAEILKQTGLPASSLELEVTESCMMSNPELVSQDLAKLGQMGIELSIDDFGTGYSSLSYLKKLPLHKLKIDQSFVAGLPFDTHNTAIAKA
IIAMGHALNLQVVAEGVETQAQADFLKDNHCDHAQGYFYSKPKLVEELTAFLI-------
>tr|Q8EBV6|Q8EBV6_SHEON Bifunctional diguanylate cyclase/phosphodiesterase with PAS sensory domain OS=Shewanella oneidensis (strain MR-1) GN=SO_3389 PE
--------------------------------------------------------------------------AQSIDIIDLQTFIDSFEEHIWVKNTE
GVYTICDLPRSDIVGKTDEDLFGKA---I-----ADDLA---------------------IEANKNNHLWLETLKLPALTPDGELAGVIGMTRNISKHKE
VEE-----TNVFKHSFEGVVVTDRHGNITDVNGAFYEITGYSREELLGQNPRLFNSGRHEKAFFETMWNNLLGGGKWNGEIWNRRKDGTIFP--QTISAI
YDEVGEIRYFVAVFADISAQKQSEAQLAHLAYFDPLTHLPNRMKLMIQLKQEIMHAKRLNSQLATVFIDVDLFKHINDSFGHSIGDEMLVELAKRLRSQL
QEQDVLSRIGSDEFVALISGIQYHEATAAINQLRQVFEQPFVVTGDHLRLTATMGVSLYPSDGSNADTLLRNADAAMYRAKSEGRNNYAFYTESLTKESI
EHLKLQSALYGALEQNALYLMYQPKVDLVTRKTVGVEALLRWNDPILGQISPSVFIPVAEKSGLIYDIGLWVLETACQQGVHWLAAGKQFGRIAVNVAGQ
QLQRNSFVEDVKRILTQTGLPATCLELEVTESVMMNNPDVAIRDLKLLGDLGIVLSVDDFGTGYSSLNYLKKLPIHKLKIDQSFVRDIPFDTNNTAIAKA
VIVLGHALKLEIVAEGVETAEQADFLTQNLCDQAQGYLFSRPQLPADVEAFFT-------
>tr|A8H0J8|A8H0J8_SHEPA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella pealeana (strain ATCC 700345 / ANG-SQ1) GN=Spea_0758
--------------------------------------------------------------------------SHQASQLSLQAFIDCMKEHVWVKDTS
GRYMMVNRPREQILNFTDDELFEPR---L-----AKDES---------------------IRQIGDVDSWLETTKVPAINDDGELTGVIGISRNIASHKA
AKD-----SRVFENSVEGVIITDVDGAIIDAHGAYSEITGYTKEELLGQNPRVLNSGRHKKAFFTEMWNDLLSKGKWHGEIWNRRKSGAIFP--QNISAV
YDIEHQIRFFVAVFNDISAQKQSEAELAKVAFHDPLTKLPNRMALNTGLEQELKQASHSNTRLGLVYIDVDLFKQINESYGHPVGDEVLLEVSRRFSQSL
GDLVTAARLGSDEFALLLPNIDSNDLLQQINNLRKVFDQPFILEHGQARLTSSMGVAIYPDDAQDPSGLLVNAEIAMHRAKQDGRNNCAFYTESLNQESV
AKLKLQSALHDAIELNALYLVYQPKISFVTGDVVGFEALLRWDDPAFGAVSPAVFIPLAEKIGLIQDIGRWVLKRACEQGQRWREQGVNFGRIAVNVAGQ
QIQRSSFVDEVAETLKQTGLPASCLELEVTESYMMSEPELVSQDLAKLGLMGVELSIDDFGTGYSSLSYLKKLPIHKLKIDQSFIAGLPLDTHNTAIAKA
IIAMGHALNLKVVAEGVETQAQADFLKDNLCDHAQGYFYSKPKLVEELTDFLH-------
>tr|Q083Z5|Q083Z5_SHEFN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella frigidimarina (strain NCIMB 400) GN=Sfri_1569 PE=4 S
--------------------------------------------------------------------------EPVSLDVDLQSFIDAFEEHMWVKDAN
GHYVACRKSTEQIVGKTDFDLFDPR---T-----ANDLA---------------------ISNVNFNKVWLETIKAPIYNTQGQLTGVIGMTRNIAKHKE
AQD-----ANVFQNAVEGVVITDSNGNITEINQAFTDITGYSREEVIGQNPRMLSSGRHPKSFFERLWNTLLVQGKWHGEIWNRRKHGAIFP--QTISAV
FDKLNIIQYYVAVFADISAQKQNEEKLKNLAYFDPLTQLPNRMQFMSLLEQEVNHSHRAKKQLAIVFLDIDFFKHINDSLGHVIGDEILVELAKRLSYAL
SDFDVLARLSGDEFVVMLPSIMGTDVTSSVDRIRSVFERPFILNTQSVRLTASMGVAIYPSDGDDHDSLLRNADAAMHRAKLDGRNNYAFYTESMTKQAV
AQLKLQNALHQALVNEDFYLVYQPKLKLSDLSPSGFEALIRWSDPVYGNISPAEFIPLAEKIGLIWDIGLWVLKAACLQGVEWLTQGKMFERISVNVASL
QLKRNDFVDKVRSILLETGLPAKHLELEVTESCMMNDPDAIIRDLKLLGAMGIALSIDDFGTGYSSLNYLKKLPIDKLKIDQSFVRDIPHDVNNTAIAKA
VIALGHALNLQIIAEGVETVDQADFLRLNGCDLVQGYLYSKPRLPDELNEFLP-------
>tr|Q12PF1|Q12PF1_SHEDO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15
--------------------------------------------------------------------------RSAPKGMDLQVFIDSFEEHVWIKNPQ
GVYVFCGRSKQDILGKTDLELFDEA---L-----AQDLA---------------------IAQQLSQSTWLETFKTPAVTAEGELVGVIGVTRNIAKHKA
AEE-----ATVFSNTVEGVVITDRKGFITEVNSAFTKITGYELDEVKGKNPNVLSSGHHDQLFFEKLWNTLLIQGRWQGEIWNRRKNGEVYP--QTISAV
YDDNDTIAYFVAVFTDVSEQRNTQAKLDKLSLHDPLTQLPNRAQFMSRIDNAIYYAKQEGTQLAVVFIDVDFFKHINDSLGHVAGDTILVELANRLSSIL
HPGAVLSRLGGDEFSL-LTNMASTDLIAIVNRIFSVFEAPFSCNGQSIRLTASMGLALYPSDGKDNDGLLRNADAAMHRAKQDGRNNYAFYTEAMTQESV
RLLQLQSALHEGLKMQRFSLVYQPKVDLHSLETMGFEALLRWNDPILGSVSPAVFIPIAEKTGLINEIGMWVLKTACEQGVRWLSQGKLFNRIAVNVASL
QLQRNSFVDDVQQVLLDTGLPAQHLELEVTESCMLQNPAEAIIELKRLREMGITLAMDDFGTGYSSLSYLKKLPLDKLKIDRSFIKNIVQDANNAAIAKA
VIALGHALNLQIVAEGVETKEQAEFLRLNDCEQAQGYYFSHPKPSHELDDFLE-------
>tr|A1S8A3|A1S8A3_SHEAM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) GN=Sama_24
--------------------------------------------------------------------------LGGGESGLLQSFMDAFDEHIWIKDAE
GRYRFIDLSPAQILSRKDAEVFPDR---V------SDKA---------------------VKELDKGNIWLETIKAPMYDMDGRLLGVIGTTRDIARYKA
AEE-----SKVFENAIEGVMITDSNGIITEINGAFETITGYSRDEVIGKTPKLLNSGRHERDFFENLWRALKTQGHWHGEIWNRRKNGTLFA--ESISAV
YGEDGQVRCFVAVFSDISLLKQTEAEVAQLAWHDPLTRLPNRSKLTTISQQQIKLAANRKTRLALLLIDVDLFKHINDSFGHLAGDKVLLSLSERLAALL
GAEDTLARIGGDEFVL-LTQVRRRDIPVILSAIQRAFDTSFDTEGESVRLSASIGIAVYPDDGDNPDTLLKNADAAMYRAKQQGRNRHAFYTEQMTQSSM
QQLRLQTALRGAVKNSALSLVYQPKINLRTRKLIGVEALCRWTDHELGVVSPAEFIPVAESIGLMPEIGLWVLKEACRQARIWRDQGLNPGRMAVNVSGS
QLTGDNFADSVARVLTQTGLSPDALELEITESVVLDNPASAIDTMDKLRGMGVSLALDDFGTGYSSLSYLRKLPLNKLKIDQSFVRELPTDQDSGAIAMA
IIAMGEALKLGVIAEGVENETQAEFLLRLGCTEAQGYLFARPLLASELKQLLQ-------
>tr|K5TUE7|K5TUE7_9VIBR Diguanylate cyclase domain protein OS=Vibrio sp. HENC-01 GN=VCHENC01_2738 PE=4 SV=1
---------------------------------------------------------------------------LPELLPSLQEFIDCLEDHTWIKSTD
GRYAMTQMTGSEIVGKNDFELFSS------------DLV---------------------IATDNN-NTWLETIKSPIRNQTGELIGILGMTRNVTRRKM
VET-----SKIFDNSHEGMVITDRKANILDVNSAFTHITGYAAEEVIGKNPNILRSGHHDREFYQQLWRQLESKGQWKGEFINRKKDGSIYPQLATISAV
MDDKNHLINYICVFEDISVRKAHEEKLQRMAFYDPLTNLPNRTHLISLLEQHIENGQKHQHAFATLFLDIDHFKHINDSMGHFCGDQLLTKLAERLQDVL
HLRAHVARIGGDEFVIILPNIESDSLIDTIEDILCLFNRPFEVKNESLRISTSVGVARYPQDGQDSETLLKNADTAMYLAKKNGRNGYAFYSPDLTDKSV
SHVRMQSALHEAIEKNQLHLAYQPQYNLNANELVGVEALLRWQHPDLGMISPADFIPIAEKTGLIQSIGKWVLEQACLQGRAWLDNGIEFGKLAVNVSAL
QLQQSDFISKLGAILKETGFPAHRLELEITESFLLIDPQQAIASLNLLRELGIEISLDDFGTGYSSLSYLKGLPINKLKIDRSFVSDVPSNTDSNAIVNA
IIAMGQTLSLKVVAEGIETDEQAQYLFERGCIYGQGFRFSAPVRAEKLFK----------
>tr|S6K3Q0|S6K3Q0_VIBNA Histidine kinase OS=Vibrio natriegens NBRC 15636 = ATCC 14048 = DSM 759 GN=M272_04205 PE=4 SV=1
--------------------------------------------------------------------------QDQSQIPTLQEFIDCLEDHIWIKGTD
GLYAMTQKTNQEIIGKNDFDLFSE------------DTV---------------------VETSNN-NTWLETIKSPVRNQAGELIGVMGMTRNITRRKT
IET-----SKIFNNSQEGMIITDRDANIIDINPAFTNITGYSAEEVIGHTPKILHSGHHDSSFYLNLWSELQVKGQWKGEFINRKKDGSFYPQLATISAV
MDDKDQLINYICVFEDISVRKAHEEKLQRMAFYDPLTNLPNRTHLLGLLEQHIETGQKSQQSFATLFLDIDHFKHINDSMGHFCGDQLLTKLAIRLQDTL
HLNAHVARISGDEFVIILPETQSDVLSETVDSILGVFHQPFKLSHESLRVSASIGIALYPTDGQDSETLLKNADTAMYLAKKNGRNGYAFYSPDLTHKSI
SHVRIQSALHEAIEKQQLRLEYQPQYNLEQNSIVGVEALLRWQHPEFGLVSPADFIPIAEKTGLIQSIGDWVIRQACIQGHAWRESGINFGKIAVNVSAL
QLQQSNFIDRLQVILQETGFSAQHLDIEITESFLLIDPQQAIASLNQLRELGIEISLDDFGTGYSSLSYLKGLPINKLKIDRSFVKDVPSHSDSNAIVNA
IIAMGKTLSLKVVAEGIETQEQAQYLSDKGCIYGQGFLFSPPVTPNKLFL----------
>tr|A0A0D1F5L1|A0A0D1F5L1_VIBPH Whole genome shotgun sequence OS=Vibrio parahaemolyticus 901128 GN=H334_17505 PE=4 SV=1
---------------------------------------------------------------------------ANKPLPTLQEFIDCLDDHIWIKTTD
GLYAMTKKSNDDIVGKNDFDLFSAE---R-----AXDLV---------------------VATENN-NTWLETIKSPVRNQAGDLIGILGMTRNITRRKM
VET-----SKIFNNSQEGMVITDSNANIIDVNNAFSQITGFSAEEVIGKNPNILRSGHHDDAFYQQLWQQLETKGQWKGEFINRKRDGSIYPQLATISAV
MDDKNHLINYICVFEDISVRKAHEEKLQRMAFYDPLTNLPNRTHLISLLEQHIEM----EQPFATLFLDIDHFKHINDSMGHFCGDQLLSKLAVRLQDIL
HLNANVARIGGDEFVIVLPDIDGDSLLETLSSILGVFRRPFDLNHDSLRISTSIGIALYPNDGQDSETLLKNADTAMYLAKKNGRNGYAFYSPDLTDKSV
SHVRIQSALHEAIEKEQLHLVYQPQYNLAQNAIIGVEALVRWEHPEFGLVPPADFIPIAEKTGLIQSIGEWVLKDACLQGTDWLARGVQFGKIAVNVSAL
QLQQSRFINKLKTILRETGFPAHRLELEITESFLLIDPKLAIASLNQLCELGIEISLDDFGTGYSSLSYLKGLPINKLKIDRSFVSDVPNDNDSNAIVNA
IIAMGTTLSLKVVAEGIETPEQVAYLVDKGCIYGQGYLFSPPVAAEKLFN----------
>tr|A0A084TC67|A0A084TC67_9VIBR Diguanylate cyclase OS=Vibrio sp. ER1A GN=HW45_13225 PE=4 SV=1
--------------------------------------------------------------------------MSSKQIPTLQQFIDALDDHVWVKDAD
RKYIAVNMPRSDIFGKTDFDLFAK------------DRV---------------------IDSAYG-HVWLETIKSPIQQPDGELIGVIGMTRNVTRRKQ
VEV-----SEIFNNFQEGMMITDQNGKILDVNSAFSEVTGYQAIEVIGKNPRFLQSGHHDAQFYQNLWQQLSETGLWKGEFINRKKDGSIYPQMATISTI
NDDGNSLLHYICVFEDISKQKAHEEKLRKMAFFDPLTNLPNRSHLTSILEQSIEGGQRHSEQFATLFLDLDHFKHINDSKGHLYGDRLLSQVADRLADVL
HHRASIGRIGGDEFVIILTDYDSEALLDTIDETLGVFNRPFELSQESLRVSGSIGVALYPQDGHNSETLLKNADTAMYLAKKNGRNGYAFYSPDLTYSSV
LHVRVQSALHDAVEKQQLSLVYQPQYDLTNNTLIGVEALLRWNHPELGVIAPAQFIPIAEKTGLIQRIGAWVIREACEQGRRWLDQGIEFGKIAVNVSGL
QLQHPNFVTKLKQKLLDTNFPAERLEIEITESFLLIDHQLAVDTLNQIRELGIEISLDDFGTGYSSLSYLKGLPISKLKIDRSFICDVPDENDSNAIVQA
IIVMGETLSLKIVAEGVENGDQVEYLRSHGCEYGQGYVFSKPVTADQLATLFV-------
>tr|S6ALU9|S6ALU9_9PROT Response regulator receiver modulated PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Sulfuricella denitrifi
---------------------------------------------------------------------------K--SDSMLHAIIEAEPECVKIVGAD
GKLRYIANSPKEILGKNMSDLILPE---Y-----RKNQV---------------------IKGLKGGHHWLEAHAVSLEMEDGPA--VLGVTRDITSRKL
AEASS-------------------DGTYLNCGGRN--MMGIPKDEDI---SSIIHA-EAIPAMREGTW---------SGETAFLTRDGREI-PVSQIIAH
RGKNETPEFFSTVVRDISERKRHEAELIYLANHHALTGLPNRNLLADRLQQSLIEAKRHDRLAALVFLDLDRFKNITESLGHEVGDLALQMVAEQLTGLV
REGDTVAHPGGDEFALLFSDVAHSEAARLAQKVLHFENFPLTVGGHKLFVTFSAGIALYPTDSENADGLLQAALTAMDRSQALGGNSYQFYSSEMNIKAL
ENLAMASALHDAIARDELELHYQPQVDLASGEIIGMEALARWRHPQHGMVSPMVFIPLAEETGQISLIGAWVLREACRQNKAWQDEGLPPLRVAVNLSAR
QFCQRDITAIVAQALADTGLESRFLELEITESMLMHDVNATISIMQQLKELGISFSLDDFGTGYSSLSYLKRFPIETLKIDQSFVRDIPHDKDDSAIAAA
IIAMASALGIKVIAEGVETPEQLAFLNTQKCTGMQGYYFSKPLPSEEFAQLLR-------
>tr|A0A081C3K1|A0A081C3K1_9BACT Sensory box/GGDEF family protein OS=bacterium UASB270 GN=U27_06132 PE=4 SV=1
---------------------------------------------------------------------------KQEHWSQLERAVEMMQIGVFIVDLD
GKILYHGYEEEELLGQELSFLNAPD---V-----GNTNG---------------------LIR-TTFPVWLMSEIV--QNADGEPWVIVTSCEDITERKL
AEEELKRSRTLLEAAPDPVVVYDGEGTYL--NPAFSRVFGWTLEESRGQ----AEN-RLILKIRQNLP------VSGIE-TSRFTKAGKRI-DVSS-AGF
FDAQGALLGSVITIQDITERKKTEEEIRFIAYHDALTGLENRKSFYMRLEDHILRLHRISDKWALMFLDLDRFKYINDTLGHDVGDELLKVIAVRLQKCV
RKTDYVFRLGGDEFTILLNGLSTDAAARVAQKIRRTVALPCEIKNHELFITVSLGISIYPHDGQDVETLVKNADMAMYAAKEES-EGYRFFTEEMNQKAL
ERMRLERSLRTALQNNQFIVHYQPLINS-QNRILGMEALVRWHHPEYGLINPSRFIPLAEETGAIVSIGKWVLHTACQQTKLWHDMGYANLYVSVNLSTR
QFKEPDLIETIEQVLEVTGLPSNCLKLEVTESGIMENPDQAIVTMHYLRAKGIRFSIDDFGTGYSSLSYLKRFPIDTLKIDRSFVMDSIQNKNDQEIIKT
IISMARTLNMEAIAEGVETREQHEFLIQQGCQMMQGYYLGLPMPAEQFQERLD-------
>tr|W0SGE2|W0SGE2_9RHOO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_02316 PE=4 SV=1
--------------------------------------------------------------------------AFNEKSRESRALLDAIPDPAWLVDTS
GRFLAIHKPMDAILGTTAKDLWSPE---V-----ARQAV---------------------YREIGNGPQPFEIVRAPVYNERGDPTGIAGVAWDISERYM
AEE-----AHVFDHSAEAVLIMDAEGKIIALNKSFSGITGYVIDEAKGHLPTLVAAERHDTNFFESIARSLAAQNAWRGDAWLKRKSGADCP--VNVSLI
KDEQGKIVNLIAFITDLSERKAAEARIESLANVDQMTLLPNRQGFSRALDDWLA-T---NPRGALLVFDIDQLGRINDAFGHMAGDELLGTICIRLRALL
KQDDLLGRLVGGQFAILVKQAADRQMAAMTRRLIEAIAQPVTIHGSDIVAKACAGICMIPEDGTSSAALLRNAGAAMHNAKTSGQSVHRFFAADMSVGVA
ERLRLESDLRWALQRNELVLHYQPQVDIASGRIIGFESLLRWRHPELGMLMPDSFIPLAEESRLILPIGTWVMEEACRQNRAWQHEGLPPLVVAVNLSAV
QFHEHDIVSIVARTLAASGLEPCWLELEITEGVVMQEPERVIRVLQELRDLGVRLSIDDFGTGYSSLSYLKRFPIDKIKIDKSFVRDLDRSAGDAAIVRM
VIAIAGELEHKVIAEGVETEAQLEFLRQHNCLEYQGYLCSQAVPADKVSHLLG-------
>tr|K0I8K4|K0I8K4_9BURK Sensory box protein OS=Acidovorax sp. KKS102 GN=C380_19175 PE=4 SV=1
--------------------------------------------------------------------------ALTGTAARLHAITQAIPDVLLVLDAQ
GRYVEVVASAPVLVGQRLHDVLPAE---Q-----AEIDT---------------------LQSLSGLRQFEGRTQPL-GVQVGDQAAVVFLARDITKRKQ
AESAL---RSLRNIPSISVQGYLQDGTTSYWNQASEQLYGYTAEEAIGANLLLIIPPPMRNHMQHMF---ATGEVIPAGELQLQRKDGTPVHVFSSAY--
IQVLGHPPEMFCIDIDISGRKAAEDEARYLAFYDALTQLPNRRLLVDRLQQVLVNGARSGLTTAVLFVDLDNFKTLNDTRGHEVGDLLLKDVAQRLRSCV
REQDTVARLGGDEFVVVLQNLSSDAARTLGELILAQLRQPYELAGHEHHFTASIGVTLLNHQRDSVDEVLKQADMAMYRAKDDGRNTLRFFDPDMQQAVN
RRALLETELHNGLRRSQFLLLYQPQVD-SQGRVTGAEALVRWQHPVQGMVPPSEFIPLAEESGLILPLGQWVMETALRQQARWQQDPFAHLSLAINVSAR
QFLQDDFVAQVLALVRQTGANPAQIKLELTESLLLDNVDSVIATMRALKAHGLGFSLDDFGTGYSSLSYLKRLPLDQIKIDQGFVRDVLLDASDAAIARS
IIALAGSLGLSVIAEGVETTAHHQFLLAHGCQAFQGYLFGRPLTLKDFESRVR-------
>tr|A0A096ETU2|A0A096ETU2_COMTE Histidine kinase OS=Comamonas testosteroni GN=P368_11145 PE=4 SV=1
--------------------------------------------------------------------------SLKETAARLNAITHAIPDVLLILDEQ
GRYIEVMTVSAQIIGKRMHDVIPTP---Q-----ADIDT---------------------LVSSRGSRHFEGRTQPL-GILVNGFSTVIFLARDITERKQ
SETAL---RSLRHVPSISVQGYRDDGTTTYWNKASERLYGYLEQEALGRNMLLIIPTSMHENMQQIF---SFGQPIPSGEFQLQHKDGSRVDVFSSTL--
IEVPGQPSEIFCIDIDITRSKAAENEARYLAFYDALTGLPNRRLLMERLQQAIVNNTESGHSLAVMFVDLDNFKTLNDTRGHAVGDLLLQHVAERLRNGV
REQDIVARLGGDEFVVILEDLTGNAVRQLGETILAQLRQPYSLAKQNHYFSASIGASILDNPKVSPDEVLQQADMAMYRAKDKGRNTLCFFNPEMQQAMN
RRALLETELHNGLRERQFRLLYQAQVD-RDGHVIGAEVLVRWHHPTHGLVAPSEFIPVAEESGLILSLGNWIMEEALHQQARWRLDPLRTLNLSINVSSR
QLLHENFIPQTIALLEKTGADPKRIKLEITESFLLQSVDGAATTMSALQAYGLEFSLDDFGTGYSSLSYLKRLPLFEIKIDQDFVRGILQDANDALIAQS
IIKLAISLGLHVIAEGVETSEHYLALLDYGCPAFQGYFFARPMALQDFELHVA-------
>tr|A0A094IGD3|A0A094IGD3_9MOLU Phytochrome-like protein cph2 OS=Mollicutes bacterium HR2 GN=cph2_2 PE=4 SV=1
---------------------------------------------------------------------------------KGFSIILLFSTFFWVFSIV
LFIVTNNVESSRALTHY-ELVLHNI---I-----DNDIE---------------------VFTFEGIGFIS-LSIAPE----G----VIEYLDLVNDERH
VREAV--QNAQFYNTSSDLGIYDKDNNLIFGELEYEEN----------------------LDFYQKI---QLDNIDWNGVKVSRDYRISSLLINVTIV--
-SL-SSTLYIFAIILGSRSNKELISNQKKLIHFDNLTGLPNRRLLINDINTAIRN----EKPFYLGFGDLDNFKNLNDILGHSVGDKYLQDISERFIGII
SDILNVYRWGGDEFIFMFNTQNKNDTINLLASIYDIFKEPIIIKETNYNVSISIGVVRYPDHGDTIDDLVKRADIVMYDIKSHNRNTFGFFEDEYLDNLQ
REVDFENKLNEY-ELEDFQVYLQPLVKTNTNEIIGFEALSRLFDRNSELINTSEVVKVYERKGDIFKLDKYIVEQTCKYSVKLKKEFKKDFTFSFNISPI
TLSNE-YIEFLELMIEKYKINPIYFVIEIIETTGFKDINESVRLLNKLRGLGFRIAMDDFGMGFSSLSYITRLPLSLIKIDRNFIQNYQSNKFDKMLILT
IRDISKSLDIEIVVEGIETEEQLDFIKEIGAHYYQGYLHSKPMNIERLINFLQ-------
>tr|R7NCA8|R7NCA8_9FIRM Histidine ammonia-lyase OS=Eubacterium sp. CAG:76 GN=BN774_00457 PE=4 SV=1
-----------------------------------------------------------------------------ESRDTFQHTVEL----ILHK--T
IAYINALQKGSDDEWTVIEE--AK--------------K---------------------C--EN--SISV-----P-----DIDAMHFVI----YDKNI
KLWSDRVSKDILNNIGSGIIVCDTATNILFENKVAAESIKECMQDILVPTEEVEKN-NAEGDGYYDFSD--YTREYIRPVEKY--NAESGLWFEVRFTKL
IWIDA-SEVIVCTASDITQKKKNQQKIEFQAHNDFLTGLYNRMKCESDLKTIINEAIRDGVKGAVLFIDLDDFKHINDGLGHQYGDILLQQIAAGLQSIV
GLRGRCYRMGGDEFVAIVMPDMFLELERIANKVKEIFNKPWYLMETEYFCTMSMGIAVFPDDSKDVHEIIRMADIAMYESKKNGKNGYSFYDVCNKQNSV
RRLDIENNMRQAVATDEFVVFYQPVVDINTEECASCEALVRWDSKSLGFMGPGDFIPLAEYLGLITSIGDYVLEEACRQCRYWNEHGMPDFHINVNLSVV
QLLQKDIVDTVAKVLKKTGVNPRNIVLEITESFAINDMDRVLNIINGIRELGPKIALDDFGTGYSSLNYIKQLPFDIIKVDKTFIDDITEDEYAQAFIKL
IVELSATIGTKIVVEGVEDKSQLDILRELGVDFIQGYYYGKPEPAYEFERLNF-------
>tr|R6KW54|R6KW54_9FIRM Histidine ammonia-lyase OS=Eubacterium sp. CAG:248 GN=BN561_02167 PE=4 SV=1
-----------------------------------------------------------------------------ESKDTFQNIVEV----ILQK--A
NTYIQAIQENSDKDILDYAL--IE--------------R---------------------VENAG--GRII-----P-----GIKAMYVVI----SGIKK
----ARVSKDILNNIGSGIIVCDRNSAILFSNKVAAESIKECIQELMSSEEY---D-RKKAYDEDDGTD--YVKPYIRPIEKY--SAESGLWFEIRFTNL
VWIDG-SEVIVCTASDITQKKKSQQKIEFQAHNDFLTGLYNRMKCESDLKKIIKQSIKDGVKGALMFIDLDDFKHINDGLGHQYGDVLLQQIAAGLQSIV
GLRGKCYRMGGDEFVAIVMPDMFSELERIANKVKDMFNKPWYLMETEYFCTMSMGIAVFPDDSKDVHEIIRLADIAMYESKKNGKNGYTFYDSCSKLNTA
RRLDIENSMRQAVTSEEFVVFYQPVVDVRTGECSSCEALVRWDSKALGFMGPGDFIPLAEYLGLITSIGDYVLEEACRQCRYWNEHGIPDFHINVNLSVV
QLLQKDVAETVARILKKTGVNPKNIVLEITESFAINDMDRVLDIIKGIKKLGPRIALDDFGTGYSSLNYIKQLPLDIIKVDKTFIDDIVEDEYAQAFIKL
IVELSDTIDTDIIVEGVENEAQLNILKELGVDYIQGFYYGKPVPAYEFEKLNF-------
>tr|D4S1F4|D4S1F4_9FIRM Diguanylate cyclase (GGDEF) domain protein OS=Butyrivibrio crossotus DSM 2876 GN=BUTYVIB_01924 PE=4 SV=1
-------------------------------------------------------------------------------MDDFTGIVHN----VFLE--L
YTELNLLFQMN------------------------DIAL------------------------LH--GFLK-----GKFKLPDRAAMYVAV----VKDNT
-----GNSEDALDRVPVGVAVLDNESRVLLLNSVAARSMGKALKLYTD-------------------------TGKQTLEDIY--DNSSGLWYDVNFSGL
KWING-EDVLVCTTIDVTQKIRNRQKIEYQANNDYLTGLFNRMKCERDLDEILKNMN-PGEKGCVVFLDLDNFKQVNDGLGHQYGDVLLQEIAYSLQETD
GIKNSCYRMGGDEFVIIVKPWYFDKITEIVDKISKRFNDIWHIMDVDYYCTMSMGIAVFPDQGKTVDELIKKADFAMYEAKKGGKNRFLWYTVEDEERKC
ADNGFRDSIKELVGDRDFDINYQPVFDKD-GILYGAEALVRINSGSLGRLLPAEFLPTAEYLGIMNRIGHYVFAKAVKTLKKWNGTH-PDLKMFINMAPT
QLMMPKAAENIMNIIKQWEVNPGNIYCDISEKTEFLDEKMALATLEILNGHGINISLDDFGSGKMSLGFLKDSHASMIKFDNSLVKKSRTDDVEITILRS
ITEIADILDIDIAFVGIEDDNDNNIALENKADYLGGFYYGEALPEDEFETKWL-------
>tr|W0U381|W0U381_9FIRM Ruminococcus bicirculans chromosome I, complete genome OS=Ruminococcus bicirculans GN=RBI_I00496 PE=4 SV=1
-----------------------------------------------------------------------------ESDDRFDNVCKN----FLES--I
CSALYVGYENSEPLSYELVFAFDKE---F-----NRMAL---------------------MQTLR--GVVY-----PCLTCANKYVAYFNL----LSSDE
RVWSPRRTTDVMDNMNSYVLAVAQDSEIVFASKSFEQYFG----KLVGKKESVFS------KTWCELPA--HKEGMLFGGDYY--SEIMNKWFNVSEKLI
KWHDG-RTIRLCTLNDISEKINYERVIEKQVFYDNLTGLPNRLSLDKSIQGIIE-S---DENSTVMLIDLDNFKNINDSYGHNNGDRLLKEIGKFFEDFA
QKNLSVFRFGSDEFVVLLRDQDQTEIDEICKIIHDKFNTEWQIANSTCYCTCSMGVAKFPKLDDTVNTVLKRIDLAISYAKKQGKNCTINYNETIGRILS
RQIELERLMHKDITNAHFTAYYQPIFSSSEKKLVGCEALMRWNPPEFGQVSPAEFIPMAERLGYINLLGENIIRIAGRQCKKWADAGL-DLRMNINLSVG
QIIEPDFLDKIDTLFDETGAPPDKICFEVTESLAIHDMEKMKELLKHITDKGVKIALDDFGTGYSSLNCIKEMPLNTIKIDKSFIDDIAKNPDTAVFVKM
IVNLSHDLHIAVCAEGVEEQVQFDILRDLETDVIQGYYFGRPMPSDKFEEKFL-------
>tr|E4TZ62|E4TZ62_SULKY Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sulfuricurvum kujiense (strain ATCC BAA-921 / DSM 16994 / JCM 1
----------------------------------------------------------------------------MQTEAPLYDVLNYLPDGIIMLDER
GVILFAGYKSDLLLGLNMLSLLADI---T-----VFIKV---------------------MKERDGHI-VQAVKSVRMIRHND--------VRNLTDLIQ
FNKEL---EDILSSIDEVIWY-IHNQSLQYVNKAVETIFGFTKETFLSDTTLQIHPERSLV---QMFFETLAPGQSQEIRFRILHCDGEVRWLNSR----
IHNHPKLNLFIGITSDITCSKAQSEEIAFLAYHDPLTHLPNRAKLKLQLENRFEHA--PNSPFALMFLDLDNFKNINDTMGHKIGDKILIEVSRRIRETV
GKYDFYARFGGDEFVILLQDADSA-IDLTAQKLIQVFKEPCTLNETEFFLSASIGIVLYPDDALNGDDLIKHADTAMYEAKKKGKNQFAYYHTSMERAIH
HFMYIESLIREGLTQNLFELYFQPLIDSKTLRMEGYEALLRLKHPHKGFIPPDTIIPVAEANGDIHLIGDKVLSQACDFIDALRALQDEPFFVAINVSAK
QLQRNKFVQELFDYLALRSIPSSYLKVEVTESTVMENIAVVSQQLSQLKAGGIRISLDDFGTGYSSFAYLAQLPIDTLKIDKSFILALFKDNSNRHIVEA
ISNLAHALGMNVTAEGVEEAQHYDFLLENNIDTLQGYHLCRPLPKDEILNNMQ-------
>tr|K7S2C1|K7S2C1_9HELI PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Candidatus Sulfuricurvum sp. RIFRC-1 GN=B649_01820 PE=4 SV=1
----------------------------------------------------------------------------MQTEAPLYDVLNYLPDGIIMVDER
GVILFAGYQNTILLGLNILSILADI---D-----VFIKV---------------------MRESSGGI-VKTVKSVQMIRHND--------VRNLTDINH
LNKEL---EEILSSIDEIIWY-IDNQALRYVNNAIERILGFSKETFVTNPNLQIHPDRALV---QIFFETLLPGQSQEIQFRILQIDDEIRWLKSR----
IYHHSTLHLFIGISSDITASKAQSEEIAFLAYHDPLTRLPNRAKLKLQLDSRFEHA--TQTPFALLFLDLDNFKNINDTMGHEIGDKILIEVSNRIKKTT
GRYDFCARFGGDEFVILLQDADTL-VNAIAEHLIQTFKEPFKINEMNFFLSSSIGIVLYPQDASIGEDLLRHADTAMYEAKKKGKNQFVYYHTSMQRALH
DFLHIESLIRDGLTQNLFELYFQPLIDTKTLQLEGYEALLRLPHPEQGFISPDIFISVAETNGDILLIGNEVLTQACNFIEMVRALRNEPFFVAINVSTK
QLHQEAFAKELLEYLEKRSISPTYIKVELTESAVMENIDIASRQLHQLQAGGVRIALDDFGTGYSSFAYLAQLPIDTLKIDKSFILPLFEGASNRHIVEA
ISNLAHVLGMKVTAEGVEESSHYDFLMENNIDTLQGYHLCRPLPRDKIFQKLQ-------
>tr|R1CRB2|R1CRB2_9CLOT Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Caldisalinibacter kiritimatiensis GN=L21T
----------------------------------------------------------------------------MEIQKRYQVLFQNSPDGIVYFDKD
YKILEVGYSYEECIGKDLDDMVMPV---E-----KRTEL---------------------FRKKTEDPIYVNIRGIL-VRVGNQIEGGYAIYTDITEKIR
YKEEL--L-EAIKGIDSGIWEVDAEDERVYLSENFAKLVSIDLDETSNIYEVVVVPEKNVLDYK-RYK-RGE-KEQIYCQVRIIDKDGKVRWFLVS-KGV
TNRDGDVKALHGVLVEISQIRKQEEKIKFLAYHDSLTHLPNRRKFIDILKEEIEN----NKKGTVMLLDLDNFKKVNDSLGHAYGDELIKKVAGILVDIA
EDKMTVFRFGGDEFLILIKNQDDPILEEYADNILLALQHNIVITEIEDSISASIGIVRYPNDSNTIDDILMRADISMYQAKITGKNRYTFFNQEMMNQFN
EKIEVETIIRKAISNEDFNLVYQPIINTHTGDVASFEALLRLKDK---NISPAIFIPIAERSDLILSIGKFVIKEAVRQLSQWKKEGRELKPIAINLSPK
QLYDNNLLKFLKGVLDEYGVELSYLEIEITERVLVKNQVETIKILNQLKDLGVSLSLDDFGTGYSSFNYLTFIPVDKIKLDKCLIDKFL-EMENIKVMDS
LITLAHSLKLKVVAEGIERMEQYKRLRKGNCDYIQGYLFSKPLKLNEVEKIYY-------
>tr|I9NMU7|I9NMU7_9FIRM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pelosinus fermentans JBW45 GN=JBW_00448 PE=4 SV=1
--------------------------------------------------------------------------KLSHQMGEYETLFNLIPVQIWYKDTN
NKIIRVGIPIQDFVGKSAQEFFP-V---Y-----SKDAV---------------------LRSANGENRWIYTSKIPTRNCDGIVTGLVALVVDITESKK
MEK-----AKIFESSGEAISVTDKENRFVAVNRAFSLATGYSSDEVIGREPSLLKSGCHDKIFYQNMWAAIIQTGSWEGEIWEKRKDGVIYL--KRIDQI
KDEEGNLINYLARFTDMSEKKAAEERIHYLARHDALTGLANREVLGKQLAKDIERARHSGSGVGVISLNLDRFKNINDSLGHKVGDEVLKELADRLETCS
KRTSLTARFGGDTFNFIVPKISRKEIIKVIHEVMSALERPLLHGGFELIITASIGVSVYPDDGDTAEVLIRNADTAMHKVKDNGRNFYEFFEANMNEYAS
ERLMLENNLRRALAREEFVLFYQPQVDSKTEALIGVEALIRWMRPNTEIVPPGDFIPILEETGLIIPIGKWVLAEACRQHKEWIRNGLPPIPISVNISAI
QFQEKEFLPMLSNIIKESGIEPGYLDLELTESVVMRQPEFVIKQLEFIKEMGINLSLDDFGTGFSSLSYLRYFPLDRLKIDQSFVRGLSTDLVNEAIIEA
VVALGKSLKIKTIAEGVETKQELDFLRKLECDEIQGYYFSKPLPSDDFIKWFT-------
>tr|A0A0B8VCI2|A0A0B8VCI2_PISSA Diguanylate cyclase domain protein OS=Piscirickettsia salmonis GN=KW89_00492 PE=4 SV=1
--------------------------------------------------------------------------DDSVFDNDMTNLIDNFNYFI------
DSLVKELPPMVLLLKEGYQY--QKI---V-----T-D--------------------------HDLQAQYFNL--LPFLMYQ-----LIDKNNLKIENI-
--R-----NAILDAVADGIIGVDEKEVIYFINHMACKILGYSADELIGKKIDKILHDSQGRS-LTELVKYVGQVGAF--ETEVTRKKGNILPIEM--SLI
LE--QVEKTIVISFRDITARKRHEAELVRLAQYDDLTKLANKSLFLELLGQAISRANRSKYYFALLFLDMDNFKFVNDNYGHAIGDKLLQEVAQRLKSCT
RGHDIIARIGGDEFTIILEELRDEQVFWVCEKIKTSLAYPFVIQSVEIEMAVSIGIVTFKDIYHTPEALLRYADMAMYAAKRQGTGHYEVFNQAMSDHTK
ELIHLRAGIAKAIENDELFVQFQPKVNTDTNCCQSVEALLRWKDSLYGIIKPAKFISLAEEIGIINELGLWILKQACVSCKKLEESTGQELKVSVNISMY
QMKDD-IADKVKETVLNSGINPENLELEITESHIMNNPEQAIAILLRLKKLGIKIAIDDFGTGYSSLSYLTQLPIDRLKIDSSFTQKIPADTQSVKVVQS
IISLAKSLKLKITAEGVENKDQFNFLKKLNCDEVQGYLLSHPLSEKELINFFK-------
>tr|A3DAC3|A3DAC3_SHEB5 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella baltica (strain OS155 / ATCC BAA-1091) GN=Sbal_4221 
--------------------------------------------------------------------------EDKLSQAMTQLLMP---------P--
HPIDSQALTTQRIEQLHQEYQQNQA---L-----TFAVT---------------------LWL-------QQMAEDPKLNINDELRMARAMNRMISERQK
ANH-----AAVFDYSAEGIMVTDADNHIELVNPAFCNITGYTLEEVKGRSPSILSSSRHSQHFYTTMWESLQTEGKWEGEVWNKRKNGQVYP--EAITVV
RNEQGQIIQHIGLFMDISKRKQYEQDLWYQANFDALTGLPNRKLFNERLQHEIHVAQHDSRKLAILLIDLDQFKYINDVQGHATGDLLLKDVAKRLEGIA
GKTDFIARIGGDEFVLILPRLTNELIEHMATRIIETLGMPFDLNDREIQISASFGIGVYPEDGLDVSSLTRNTETAMYQAKDAGRNNFKYFTAGMNEAMF
ARMELEQRLRRAVAQNEFALHYQPIVDMQTGVVCSVEALIRWQDPDFGLIPPDQFIPLAEETGLIEPMGEWVLNQAMHDLRQWQKSGLKI-NVAINVSGR
QCINTGFDQVLQECFNRHHVNPRNVHIEITESMLMGDASHCLSTLESIRHLGSQIYIDDFGTGYSSLSYLKKFPISVIKIDRSFVENALESNANANLVKA
IVMMGQSLEMELVAEGIETEAQWHFLRDLGCHFAQGYLISKPLPFDEITPLLH-------
>tr|U4KDJ0|U4KDJ0_9VIBR Putative EAL,GGDEF,PAS/PAC domains protein OS=Vibrio nigripulchritudo GN=VIBNI_B1369 PE=4 SV=1
--------------------------------------------------------------------------VLVRNEDQ--SFCSLTPEAEWFRQLY
C---------EQTGATFSAKKLDVS---L-----AFNDT---------------------VWG----GVWTESDAEEEQLTAGES--LLI-IENRTEHFF
EQDMMIASSDSVKSESAAVIIFNCKSKVLSINNEFKKLFHIEDASSQSLALLEAE------PVYPEMNRVLTAGSFWEGEFSTKTIQNQKHFIRLNIAPI
KNERQQVTHFVCIVHDISELRLDDKHDSNYTGYEYTTQLPNRRYFWRKLQDTVKASKKNKNTYSILYIDLDYFKRINDKYGFEQGDKVLKLIGSRISRCV
KQRDFVSHLGGDEFTIIAVGAAEQL--PMSDRLRRSISEPVLIAGESVSITASIGIATVED-KVSLVEVVKHSDLAMSSAKELGRNQCRIYTEQLDLTFS
LRLQREHDIHDAIKNDDFHLLYQPKVNVEPCDEFNVEALVRWEHATEGTIFPNDFIPIAEDSGQIIPLGRWVLDQACYDAKSLLDDGI-NIRMAVNVSTK
QLKHPDFYNHVNKALEKSGLPSHHLELEITESGLLADIDSILDVLGKVRQLGVTVALDDFGTGFSSLNYLRQMPVDFIKIDKEFVDELPANNQSMLITTS
LIELAHSLNLKVIAEGVETLKQLNCLTKVECDYIQGYYFYKPLPFSQLELAYK-------
>tr|F2JUS9|F2JUS9_MARM1 Diguanylate cyclase/phosphodiesterase OS=Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1) GN=Mar
--------------------------------------------------------------------------VLKHIKDD--SFLIHFANDNWFRSLF
P---------DNHVGD---E-VVLN---D-----TPDKE---------------------FWR----GIWSEQTGRKVRLEAEEH--FLV-LFNLENEYK
RQNTLAVVKEVIESAEFGVAIIDHDLQLVEQNPALFRLFEMLPD--VG-RPALCQ------RQFPEFQRILETRSRWSGELYWMKPPSLSRWMQLTVSPV
ESETE-GHYWLLLVTDISREKYLQQSNEKLTYFDVLTNLPNRQYYWQCLENAIE-V---GQSFFAMQLDIKQLKSVNEVFGFTVGDILLKELAERLRQLV
SPNDVLARIGGNEFAVILRET----CEQIARKMISDICAPYYVQQYKCSVGVRIGVSHFPYDSVVAEELMKYADLASFSIKQGGKSAVQFYSRELKESSL
RRMELEAALRDAIDNGEFELFLQPILDLDTGKISQAEALIRWRRPGIGLIFPDEFIPIAEKSGLIIAIGKWVIQEASRLLAVLHQQDQ-FIKLSLNLSPS
QVSDRSLLGFIQRHIEANHVDPTYLELELTENVLVNDFERINHFLSEVRKMGVSVAIDDFGTGYSSLSYLPKLPIDFIKIDRSFIGELIDSDSNRAIVLA
ILAMANSLKLGVIAEGVEVESQKAFLREHHCQSAQGYLFSRPVPFDEFCKLLR-------
>tr|A0A0D8D2I4|A0A0D8D2I4_9GAMM Uncharacterized protein OS=Thalassomonas viridans GN=SG34_26415 PE=4 SV=1
--------------------------------------------------------------------------VLEVIDSKTGTVKLIGGDNLWVGDLF
P---------QSRGRD---T-FVID---D-----ETDRQ---------------------VWR----GFWTEITKNSEHLEAQRN--LLV-IANQQEEFL
HQHTKFKLTNIIENAEFAVVIVDDNLTTIVENSAAQSLFEENKFHSQPSNPILMK------NQLPEYDRILSTKSNWNGELCWMSPPATLKWLKISFYPV
KNKLNKLENWIVFANDISTIKYLVQRNEQLALQDMLTELPNRFSFWQTLEKHIA-S---ATPFYLLYVDINNFRRHNEFYGHDEGDKLLVEFGKRLKNEI
KASDFIARVGGDEFAIILANL----CEIAIQRIFSHIKKPFTTKAEDFNISISIGAASFPHDAQTAEELMKFVDLSAYNGKKSNKNSLQFYSQSMKDASH
QAIQIENELRRAIENDEFELFLQPIVNLANNKIEKAEALIRWNHPKKGMVGPDKFIPVAEKSELIIAIGEWVISRACQLVKQINELGY-RIKISMNLSSA
QVTDRNLFSYLHTCVNNYQVDPYLLELEVTEGVLVDDYSVANKLLSKVRTIGMSVSVDDFGTGYSSLSYLKQLPLDFIKIDRSFIKDIVSDDNDKAIVRA
VIAMAHNLNLCVIAEGVETEEQLNFLTDNSCNSVQGYLFSRPVKFTDFIELLQ-------
>tr|F5Z9C8|F5Z9C8_ALTSS Sensory box-containing diguanylate cyclase OS=Alteromonas sp. (strain SN2) GN=ambt_00685 PE=4 SV=1
--------------------------------------------------------------------------IFKST--T--SLQCLTPDVSWLHKII
S---------LNDDDK---I-NPDA---F-----SSDND---------------------IWR----GFWTEENKNQARLEAGEH--FLV-IKNVESQYE
KQKTLLLLKQAIYHLETGVVILDKNRETVLDNKSARLLLSCSRS--NSSDRLDVS------VPDTFLPTLIEKRAAWQGELYWQPSENYEVWLQVTIHPV
IQDSE-LTHWVYLLTDISHIRNKEESVLSATGMDSLTKIANRNFFNSYVQKLVQ-E---DVKFALFIIDIREFKKINEKLGYHSGDEILKSFASRLQGFV
GNSGFIARMGSNEFSIVKRTDTF--TLDYAQDMKKKLVNTYTSHGAESNLGINIGIAGYPQHGEQGNILLRHADIALQIAKFQGKNVILEYSEMLQRQHK
SMSELESKLRTAIQNNQLALFLQPIVDLQTGKIVKCEALARWKTEDGSYIPPDVFIPLAERTELIFPLGEWLVEEACNAIDKLTEANL-DIRLAINISGR
QVTDLVLLHQIQSSLKRRAIDPRHLSIELTESVFIDSLDTVSVLLNELRAMGITISIDDFGTGFSSLVYLKKLPIDELKIDRSFVSDLEENTDDQAIIQA
ILGLAKNLNISIIAEGVETQEQQTFLVDNACTYAQGYYFDRPMSISDFVEKLR-------
>tr|A0A075NZK0|A0A075NZK0_9ALTE Diguanylate cyclase OS=Alteromonas australica GN=EP13_16035 PE=4 SV=1
--------------------------------------------------------------------------IFKRCQSS--QLTCLTPDVRWMRHIV
T---------LTEENA---F-DISS---S-----HSDDT---------------------IWQ----GFWTEDIEGETRLEAGKH--YLV-VKNVAEQFE
KQKTLLHLKQTIHHLDTGVVILNQHGETVLDNRSARQLLQCNTH--NTALRLDVK------VPDSFLPTLVEKRSAWQGELYWKYSDDYQVWLQVTIHPV
IHNQT-LTHWVYLLTDISHIHSKEESVLSASGMDSLTKIANRNYFNSYVRKLVR-E---DVSFTQFLFDIREFKKINEKLGYHSGDEILRAFAGRLQSAV
GNSGFIARIGSNEFAVVKRDDTF--PRDYAKHIKSILVKTYTAQGAESNLGVNIGIANFPEHGDNAETLMQHADVALQIAKYQGKNVVLVYSAELHKQHQ
DMSEMEQQFREAIEKNHLSLHVQPIVDLKTGDIVKCEALARWKKADGSFVSPEVFIPLAERTDLIFPFGEWLIAEACSAIEKLKAASL-DIRLAINISGR
QVADLALLKQIQTALKNRYIDPNNLSIELTESVFIDSLDTVSILLNELRSMGITISIDDFGTGFCSLVYLKKLPIDELKIDRSFVSELENNTDDQAIIQA
ILGLADNLNINIIAEGIENAAQQNFLLAHNCAFGQGYLFERPQSVESFIDKIN-------
>tr|A0A0E0YFD6|A0A0E0YFD6_ALTME Sensory box-containing diguanylate cyclase OS=Alteromonas macleodii (strain English Channel 673) GN=AMEC673_16185 PE=4 SV=1
--------------------------------------------------------------------------LFRCNSES--DIECLTPELPWLGNVV
T---------IDENNK---L-QKKH---I-----PSDDE---------------------VWK----GFWTEHNESQVRLEAGSR--YLV-VKNVEEQFE
KRKTLLRLQQAIHNLETGVVILDDKGGLILDNKASHRLLLCNST--PSSIRVDID------APATFLPALVQRKAPWQGELYWQPVDDYGVWLQVTIHPV
LQGDE-LTHWVYLLTDITHIHNKEESVLTASGMDSLTKVANRNLFTDTVRRLVQ-E---EIAFKLFIIDICDFKKINESLSYQSGDEILKSFALRLQTFV
GNSGFIARIGSNEFALVKREDTF--SAEYIEQLVKKLTQTYTVNGSEPNLGINIGEANFPRHCPSTESLLQCADIALQAAKYQGRNVVLTYSEELHKQHH
AISELESQLRSAIENNELKLFLQPIVDLETGKIVKCEALARWITPEGKFISPEVFIPLAEKSELIFPFGEWLINEACDAIEALKASNL-DIRLAINISGR
QVSDLALLNQIKNALEDHQLPGSNLSIELTESVFVESLDTVSVLLNELRAMGITVSIDDFGTGFSSLVYLKKLPIDELKIDRSFVSELEKNTDDQAIVQA
ILGLASNLNIKIIAEGIETQQQQQFLQNHRCAYGQGYLYQRPVAIPEFITLAQ-------
>tr|A0A0B3YJY8|A0A0B3YJY8_9ALTE Diguanylate cyclase OS=Alteromonas marina GN=RJ41_01020 PE=4 SV=1
--------------------------------------------------------------------------LFKYNPED--DITCLTPELPWLADVV
S---------LDDNNK---L-QRKH---I-----PSDDE---------------------VWK----GFWTEQTEDEVRLEAGSR--YLV-VKNVEEQFE
KQQTLLRLQQAIHNIETGVVILDSEGALILDNKASHRLLLCNST--PSSIRIDID------APSTFLPALVQRKAPWQGEIYWQPVDDYKVWLQVTIHPV
LHGDE-LTHWVYLFTDITHIHNREESVLTASGMDSLTKVANRNLFTDTVRRLVQ-E---DTPFKLFIIDICDFKKINETLSYQSGDEILKSFALRLQTFI
GNSGFIARIGSNEFALVKRLDTF--GADYVHQLQSKVTQTYTVNGSEPNLGVNIGEASFPEHCSSAETLLQCADIALQAAKYQGRNVALVYSDELHKQHH
AIHELETELRNAIKNNELKLFLQPIVDLSSGKVVKCEALARWITPEGKFISPEIFIPLAEKSELIFPFGEWLINEACDAIEALKASNL-DIRLAINISGR
QVSDLALLTQIKNALEDHQLPGSNLSIELTESVFVESLDTVSVLLNELRAMGITVSIDDFGTGFSSLVYLKKLPIDELKIDRSFVSELENNTDDQAIVQA
ILGLASNLNIKIIAEGIETQQQQQFLQNHHCTYGQGYLYQRPVEISEFISLAQ-------
>tr|A0A010Q8A9|A0A010Q8A9_9ALTE Diguanylate cyclase/phosphodiesterase OS=Alteromonas sp. ALT199 GN=H978DRAFT_0080 PE=4 SV=1
--------------------------------------------------------------------------LFKCNSEN--DITCLTPELSWLSNVV
A---------LDENNK---L-QKKH---I-----PSDDE---------------------VWK----GFWTEKNENQLRLEAGSR--YLV-VKNVEEQFE
KQQTLLRLQQAIHNLDTGVVILDSEGGLILDNKASHRLLLCNSM--PSSIRIDID------APSTFLPTLIQKKAPWQGEIYWQPVDDYKVWLQVTIHPV
LHGDE-LTHWVYLFTDITHIHNKEESVLTASGMDSLTKVANRNLFTDTVRRLVQ-E---ETAFKLFIIDICDFKKINEALSYQSGDEILKSFALRLQAFV
GNSGFIARIGSNEFALVKRLDTF--ASEYVQQLLNKVTQTYTVNGSEPNLSINVGEASFPQDCSSAETLLQCADIALQAAKYQGRNISLVYSDDLHSQHN
AIYELESKLRRAIANNELKLFLQPIVDLSSGKIVKCEALTRWITPEGKFISPEVFIPLAEKSELIFPFGEWLINEACYAIEALKASSL-DIRLAINISGR
QVSDLTLLNQIKNALEDHQLPGSNLSIELTESVFVDSLDTVSVLLNELRAMGITVSIDDFGTGFSSLVYLKKLPIDELKIDRSFVSELEQNTDDQAIVQA
ILGLANNLNIKIIAEGIETQQQQQFLQNHQCAYGQGYLYQRPVAIAEFIALAQ-------
>tr|S5CD72|S5CD72_ALTMA Uncharacterized protein OS=Alteromonas macleodii str. 'Ionian Sea UM7' GN=I635_17010 PE=4 SV=1
--------------------------------------------------------------------------LFKCSAEE--ELECLTPELPWLPHVV
T---------LDEKNR---L-QKKH---I-----PSDGE---------------------VWK----GFWTEQNEKQVRLEAGSR--YLV-VKNIEEQFE
KRKTLLRLQQAIHNLETGVVILDDKGGLVLDNKASHRLLLCSST--PSSIRVGID------APASFLPTLVKKKAPWQGELYWQPVDEYKVWLQVTIHPV
LQGDE-LTHWVYLFTDITHIHNKEESVLTASGMDSLTKVANRNLFTDTVKRLVQ-E---ETAFKLFIIDICGFKRINEALSYQSGDEILKSFALRLQAFV
GNSGFIARIGSNEFALVKREDTF--SEQYVKNLIQKLTQTYTVNGSEPNLGVNIGEANYPAHCSSSEGLLQCADIALQASKYQGRNTALTYSEELHKQHF
AINELENQLRKAIDENQLKLFLQPIVDLTTGKIVKCEALARWITPEGKFISPEVFIPLAEKSELIFPFGEWLINEACNAIDALKGANL-GIRLAINISGR
QVSDLALLNQIKNALEDHQLPGSNLSIELTESVLVESLDVVSVLLNELRGMGITVSIDDFGTGFSSLVYLKKLPIDELKIDRSFVSELEKNTDDQAIVQA
ILGLAHNLNIKIIAEGIETQQQQDFLQSHQCAYGQGYLYQRPVAIKEFISLAQ-------
>tr|K6YAE3|K6YAE3_9ALTE Diguanylate cyclase/phosphodiesterase OS=Aliiglaciecola lipolytica E3 GN=GLIP_0991 PE=4 SV=1
--------------------------------------------------------------------------ILKRESNR--QFQLLHCNEQWFYALA
P---------EAIGHE---T-FEFA---G-----NSDED---------------------FWQ----GIWTEQSKDRLRLEAGES--YLI-INNLEVEYR
QQNTLLRLKRVIENAEFGVIITDASITPINQNPNAYLLLETTDE--FEETPFLFK------HQCAEYERVFDTASRWHGELFWHKPPYSSKWLKLALYPV
KDANEKVCNWIFIFSDVSRIKYLMQRNEKLSLYDNVTSLPNRQFFWQKLEKQIE-Q---EKPFFVVYLDVKQFKQINELHGHQAGDQILVELANRIQQCL
SESDLCARIGGNEFGMIISGT----CSDLVQRLIESAELPLYTSKQKVQVSLSLGAAHFPSDASDSEELMKFADLAMFSAKKGSKSKLRFYSKALKEESM
RRLELENALRKAIDENQFELFLQPIMNLATGVITKAEALIRWRMPDGSYTSPDQFIPLAEQTGLIIPIGKWVLSRAVEMVKVVLQHQP-DLKVSVNISPR
QIADRQLFEFVSKVIDHSGIPAQNIELELTEGVLIDSYDRVKKLLEQVRDIGISTSIDDFGTGYSSLSYLQKLPIDNLKIDRSFVYDLEQNENDKAIVLA
VIAMARSLKLGVIAEGVENQYQADFLLDNKCDIAQGYLFSKPLPFEQFCDLLI-------
>tr|K6XPL1|K6XPL1_9ALTE Diguanylate cyclase/phosphodiesterase OS=Glaciecola agarilytica NO2 GN=GAGA_3459 PE=4 SV=1
--------------------------------------------------------------------------IFKRVDVD--QFEAVYAEHEWLDILL
P---------GARDKQ---F-FKTP---T-----DSDEE---------------------FWE----GIWNESIADNEKLNAGDF--YLI-INNVKQQFE
RQQTLLNITEVIEKTEVGVAILTPNLKPISQNPALYSVFDSHLP--VESEPYLFE------KQYPEFERVISTGSRWSGELFWLQPPGNGKWIKLAIYPV
KTDFQQITHWVFIVNDISQVKHLLQNNEKLTHYDALTDIPNRQYFWMQLEQSVS-N---AMPFYVLYLDIKNFKRINEIHGHSRGDQIIKELVERLTPHV
SPGDMFARIGGGEFAIIRQKT----CVDLGNTLIDAATQPFYLNGTHCEIGLNIGAASFPRDADDAETLMKFADLAVFNAKKASKSSVQFYSQALKDASQ
RIIELENALQTAITNHEFELFLQPMLDLTSGTILKAEALLRWNRLDGERIGPDEFIPIAEQTGLIVPIGKWVISRACEMISTLNHRGH-SCKLSVNLSPR
QISDRHLLEFIRGSIQNSHIQPDQLELELTEGVLVDNYDKVQYLLTEVRKLGVSVSIDDFGTGYSSLSYLKKLPIDHIKIDRSFVQDLVSDENDKAIILA
IIAMAHSLKLNVIAEGVETELQRNFLQLNHCNLAQGYLFSRPLPFAQFCDYLN-------
>tr|K6YI32|K6YI32_9ALTE Diguanylate cyclase/phosphodiesterase OS=Glaciecola polaris LMG 21857 GN=GPLA_1460 PE=4 SV=1
--------------------------------------------------------------------------VFKRLDAD--HYETLYAEHEWIDLLL
P---------QARQEK---S-FTSP---C-----DSDEE---------------------FWE----GIWNEKINDQEKLNAGDF--YLI-IDNVLDLFQ
RQKTLLNITEVIEKTEVGVAILSPNLQPISQNPALYSVFDTQLQ--AETEPYLFE------KQYPEFERVISTGSRWSGELFWLQPPGNGKWLKLAIYPV
KTDFQQITHWVFIVNDISQVKHLLQNNEKLTHYDALTDIPNRQYFWMQLEQSVN-N---AMPFYLLYLDIKNFKRINEIHGHSRGDQIIQELVERIAPHI
SASDMLARIGGGEFAIIRQKT----CIDLGHILIETATQPFYLNGTHCEIGLNIGAASFPRDADDAETLMKFADLAVFNAKKATKSSVQFYSQKLKDASQ
RIIELENALQNAITNHEFELFLQPMLDLTTGTILKAEALLRWNRLDTEKIGPDEFIPIAEQTGLIVPIGKWVISKACEMISTLNHRGQ-NCKLSVNLSPR
QISDRHLLDFIRTSIKNNHIQPDQLELELTEGVLVDNYDKVQFLLTEVRKLGVSVSIDDFGTGYSSLSYLKKLPIDHIKIDRSFIQDLVNDENDKAIILA
IIAMAHSLKLNVIAEGVETELQRNFLQLNHCNLAQGYLFSRPLPFAQFCDYLT-------
>tr|K6Y523|K6Y523_9ALTE Diguanylate cyclase/phosphodiesterase OS=Glaciecola arctica BSs20135 GN=GARC_2109 PE=4 SV=1
--------------------------------------------------------------------------VFRRLSSA--KFEVLYRAGNWLDELL
P---------EIVDTK---V-FCFA---Q-----NSDEN---------------------LWQ----GLWSEQLSTQLRLEAKQN--YLI-VSKLEAKYQ
KQQTLLSAAQALTQTDLAVAILDADLHLLNSNPALRTLFDDTNK--IGLPPDLFR------TQYPECERIFSTASSWTGEIYWLNPPQQGKWLKLSIHPI
KNDEQRVQNWLFSVSDVTQVKYLLKRNEKLTHFDALTNLPNRQYFWQQLESKIQ-Q---NRPFYLLYIDIKQFKRINELHGHVVGDEVIKDLSKRLNAIT
HVDDMIARIGGTEFAVIMQLNHLHTCIKFAEELIRVSCLPFYLSGLKCEVGLNVGATAFPADTNSAEELMKYADLAVYSAKKKAVSSIEFYSKELIDASR
KRIDMENSLRSAVENQEFELFLQPMLDLASGKIIKAEALIRWHHPNGYLVPPDEFIPLAEQTGLIIPIGKWVVTEACAILKRLAEKGE-EIKLSINLSPR
QVNDRQLFEFIKESVTKAQVNPHHLELELTEGVLIDNYDKVYYLLDEVRKLGMSVSIDDFGTGYSSLSYLQKLPIDRLKIDRSFINEINEQDSDGAIILA
VIAMAHSLKLEVIAEGVETVLQRDFLKLNNCNIAQGYLFSRPVPYDEFCDLLE-------
>tr|G4QJ89|G4QJ89_GLANF Diguanylate cyclase/phosphodiesterase OS=Glaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064) GN=GNIT_3137 PE=4 
--------------------------------------------------------------------------VFKLRSGS--VFEVVQSTPSWVSKLV
P---------SINNGD---N-VDLA---E-----VSDHE---------------------FWK----GIWTEALQDDNHLEAPDQ--YLV-INNVNDAYR
QQETLLMGREAIQYASIGVVITDIEFHISESNPSSYKIFEMEVL--SDQSPILLN------KQFPEKDRIFETQSGWTGELYWHLPPNYHKWIQLGIHPV
KDENGNLCNWIFTTSDVTRVKYLLQTNEDLSLHDALTKLPNRQYFWQTLDQTIA-S---QTPFYVIYLDISNFKNINELYGHLTGDQLLTQVAQRLRNLV
PERDFIARIGADEFAIVHFAKDNVSTIKLTQELSAASNEPYYTKDRRCELPLKIGVSTYPSDAGTVEELMKYADLALHHAKQTGTDPIQFYSLDLKIASE
RRLMLEEALRHAIEKEQFELYVQPIYDLRTNTIVKAEALLRWHISDDEMISPDIFIPIAEQSGQIVAIGRWVISSVCELLAQMSKQNL-SVPLSLNLSPR
QISDRHLFDFINNAVIKNKVSPDLLELEITEGVLVDNHEKVRKLLQELREMGVTVAIDDFGTGYSSLSYLKYLPIDSLKIDQSFVFDLGYNSDDQAIVLA
VIAMAKSLKLGVVAEGIETQQQKDFLEQHDCIIGQGFLLSRPLTIYNFIKLVE-------
>tr|A0A0D8CR67|A0A0D8CR67_9GAMM Uncharacterized protein OS=Thalassomonas actiniarum GN=SG35_23360 PE=4 SV=1
--------------------------------------------------------------------------VLEVIDSTTCSVRLIGGDSDWAKALF
P---------QLASQQ---A-FIIT---D-----ETDRQ---------------------VWC----GFWTEVTQNTEHLEAQKN--LLV-IANQYEDFL
QQHTKFKLTKIIENADFSVIITDNKLTPLVENSAASSLFKEEQFQIQPAKPILMK------NQLPEYDRILSTKSHWDGELCWMSPPSTLKWLKISFYPV
KSKLNEVENWIVFANDISTIKHLVQRNEQLALQDMLTELPNRFSFWQTLEKHIA-S---AKAFYLLYIDINNFRRHNEFYGHNEGDKLLIECGKRIKSVI
KASDFIARVGGDEFTVILTDI----CEIAIQRIIGHIKKPFITKGEAFTISISIGAANFPNDAKTAADLMKFIDLSAYNGKRNNKNSIQFYSQSMRDSSH
QLIQLEHELRLAIKNNEFELFLQPIVDLAKNNITKAEALIRWNHPKKGMISPDKFIPVAEKSDLIIALGEWVIQRACQMVKKLAKLGY-NIKISMNLSSA
QVTDNNLFSYLHACVKNYKIDPCLLEVEVTEGVLVDDYSVANKLLSKVRTIGMSVSVDDFGTGYSSLSYLKQLPLDFLKIDRSFINDIVTDDNDKAIVKA
VIALAHNLNLCVIAEGVETQEQLSFLTDNACNSVQGYLFSRPVQFNAFVELLK-------
>tr|R9A5H9|R9A5H9_9LEPT Diguanylate cyclase (GGDEF) domain protein OS=Leptospira wolbachii serovar Codice str. CDC GN=LEP1GSC195_1514 PE=4 SV=1
---------------------------------------------------------------------------------------MGIPISVLILEND
SNSVFDGLSPLYRVVET-FP--------S-----WEDDA---------------------IIC----RPFHSEIPIYLQYLNDKKIPVILLVNDLIDRKN
LLRLTSL-QKALDQA-NIVSITDANGIITYVNESFSKATGYTVSELIGQNHRILKSTKTKD-DWTKIWETIQKGKVWRGEIRNIKKDGSDYWADTTIVPF
TGQDGSIFQYIAIHHDITNRKLAEQQLTHDAFYDNLTGLPNRALFLARIEQKIFAYNKSSGYPILFCINIDNFKRINHSLGNDAGDQILVIFSERLRQFS
DSDAIITRLGADNFSILLTHLLAIDGVNYAIRLLERLGDPIPLGGYEIYLTASCGISAFGLGGKDADVLLRNAEIAMFHAKSQKVGTVSVFNQAMQEKIH
FQLEIQNDLKKALTHNEIFVYYQPILDLKENKIGHWEALVRWRHPQRGMVSPAEFIPLAEDSGLIVPITRFVLEQAANVIEEVQIKQL-PISIAVNLSPQ
VFFDQNIFHWIVDLHNRRGIPYTSLQVEITESLAMKNLTETVPILSNLIDIGVKVALDDFGTGFSSLSYLEKLPLSIVKIDKSFLSNVEEGSKESFLLIS
IINMAHDLGYSVVAEGVEELEQLELLKSYECDKIQGYWLSKPIGSEDVVPFIH-------
>tr|R8ZPV4|R8ZPV4_9LEPT Diguanylate cyclase (GGDEF) domain protein OS=Leptospira yanagawae serovar Saopaulo str. Sao Paulo = ATCC 700523 GN=LEP1GSC202_
---------------------------------------------------------------------------------------MASPISVLILEDD
SSSVFDGLSPLYRVVES-LQ--------N-----FEDDA---------------------IIC----HPFQLEIPHYLKFLNEKNLPVILLVNDIIDRKT
LLRLTSL-QKALDQA-NKVSITDANGIITYVNDAFAKATGYQSFELLGQNHRILKSQKSKE-EWEKIWETIHKGNVWRGEILNTKKDGSIFWVDTTIVPF
IGTDGSVFQYIAIHHDITDRKLAEEQLTHDAFYDNLTGLPNRALYLARIEQKIFTYNKKDGYPIVFCINIDNFKRINHSLGNEAGDQILIIFAEKLKQFS
DKDAIITRLGADNFSILMNHLLSIEAVDYAYRLFEYLGDPIPLAGYEIYLTASCGISAFGLGGKEADVLLRNAEIAMFHAKSQKVGTVAVFNQAMQEKIH
FQLEIQNDLKKALNQNEISVFFQPILDLKSNQIGHWEALVRWRHPQRGMVSPAEFIPLAEDSGLIVPITRFVLEQTANVIEEVQIKKY-PISIAVNLSPQ
VFYDQNIFHWIVDLHKRRNIPYASLQVEITESLAMKNLSETVPILSNLIDIGVKVALDDFGTGFSSLSYLEKLPLSILKIDKSFLNNVHVGSKESFLLVS
IINMAHDLGYSVVAEGVEELEQLELLQSYQCDEIQGYWLSKPIPFPDIIPFLD-------
>tr|F9DUH1|F9DUH1_9BACL Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sporosarcina newyorkensis 2681 GN=HMPREF9372_2452 PE=4 SV=1
--------------------------------------------------------------------------AKARTDLQNFKYALDESAVVAITNPQ
GMITYVKYSRDELIGKTHRVVNSGT---H-----PKMNT---------------------IQQKDGEFYWVNTTIIPFVGADGKPFQYISIRQDVTSHKA
AEKSLSL----------------KYEHFTLLEGKITEKLGMTKD--T-------NL-TSIKHLQEGLH-GLS-SQFEIEYKSYTF-----L----VLSPI
FEEDEVAE-VVGTAIDITDRKEAERLVKHMAFHDHLTDLPNRRLLKQTVENAIEDRAKSKEPFALLYIDLDRFKNINDSMGHYVGDQLLKSVGERLGLLV
RQNDLVARLSGDEFIVLCKSTNKN-GVRLVAKRIEEISKSFLINNLVVFIAPSIGISLFPEDGEDYDTLMRNADSAMYLAKQSGKGTYQFFTEELYNDLI
ERTLLEMELRQALKKDELSLHYQPQLDFTTGKIKGVEALLRWNHSSRGMISPGQFIPIAEETGLILPIGLWVLETACKQAKEWQDLGYPPLRMSVNVSLR
QFKSHTFVSDVKETLRTTGLQPNYLNIEITESMT-SDVNNCQKVLQELREIGIKASIDDFGTGYSSLSYLSKFPITHLKIDQSFVRELT---DNSVIVKA
IIDLAKNLHLQVIAEGVETIEQAEFLKTLNCDEAQGFLYSRPVPSEEIAKLLE-------
>tr|K6ZVE3|K6ZVE3_9ALTE Diguanylate cyclase/phosphodiesterase domain 2 OS=Glaciecola pallidula DSM 14239 = ACAM 615 GN=GPAL_0405 PE=4 SV=1
-------------------------------------------------------------------------------N---HSFY----TFFKVKPEN
TVGFLIDIPALRELLESIDYLVEYD---F-----ANRIE---------------------KEEKLADELVIANQEKDK--LADELVN-VG-----TERKR
LLQ-----ATIFNHSHQSIMITDGDATITEVNSSFNQITGYDSKDVIGKNSRMLKSGDESSAFLAEMWDTLLSKGHWHGEIWYRRKNGDIYP--ATITAM
KNADGVVDHYVSLSTDISSMKALQGQLKHLAHFDALTNLPNRVLLADRLSQGKEQCKLNNRTLAIAFMDLDGFKEVNENHGHQVGDELLIAVSQRMKAAL
REGDTLARYGGDEFIAVMVNLEKNESETVLKRLLKATADTVISGDTEMQVSASIGVAFYPQDGIEADPLIRHANQAMYNAKQAGKNRYCLFDTQQHNAVK
VQLESIEDIVLALEKREFVLFYQPKVNMQTGEVIGVEALIRWQHPVRGLIPPLDFLPVIEGKAISLELGERVIENALTQISQWQSAGLNL-PISVNISAY
QLQQDNFATRLAALLSAPEVNPYCLELEILETSALNDINKVFATMSACNMLGVRFALDDFGTGYSSLTYLRRLPAQLIKIDQSFVRDMLEDAEDCAIVEG
IIGLAKSFRRDVIAEGVETMHHGRELLQMGCELAQGYGIARPMPAGDIHEWVS-------
>tr|R8NLL8|R8NLL8_BACCE Diguanylate cyclase (GGDEF) domain-containing protein OS=Bacillus cereus VD214 GN=IKI_04953 PE=4 SV=1
------------------------------------------------------------------------------------------------DDEI
FKYIYINKIGMDYAGLSEECY-GKT---FAEVLSGDKVKILQEQYTKVVREARAHTFCDVISFPTGNL-HYESSVNPVYDEEGVCQFIICITRDITAQIE
EKAEIEEKQSLLEYNNDSIISIDSIGRITYANPATYEIFGYRYEELNNNFIFNFIIKEYEKDFQIIFKEALQ--GRAKQSKKYVHKEGYELYISLRTIPI
-IVNGEIVGVYIVTRDVTRQVLNEMKTEYLAYYDQLTGLMNRISCTNKLNEFLNE----NKELALVFMDLDEFHLINDTFGHKEGDKVLQKVTECLSNLE
IEGMHLFREHDDQFVMLIENITKEYVEEVAKNILEKISEHFVIEEEDVYLSVSIGIVMAPTDGADEKILFQRVDAALEKAKEKGKGHYHFYCKGLDCERE
KRFVMENQLHRAIEKNEFFLYYQPQVNIETKKIASMEALIRWENKELGFVPPNQFIPLAERTGFIIKLDEWVVDQVCQQIREWLNKGYEVVPIAVNISAR
HFRSITLIEMITRALNKYNVPAHLLAIEVTEGALIHK-DISKRVLLQLKEQNLKIHLDDFGTGYSSLSYLKTYPIDTLKIDRSFMEGIHVDERDTNITAA
IIHLAHTLELNVIAEGVEKAEQIQFLKEKNVEIVQGYYYSRPLSKYDVENMYY-------
>tr|A0A0D1QVZ2|A0A0D1QVZ2_BACTU Contig0034, whole genome shotgun sequence OS=Bacillus thuringiensis Sbt003 GN=C797_19644 PE=4 SV=1
------------------------------------------------------------------------------------------------DNET
FQYMYVNKIGMDYARLSEECY-GKT---FAEVLPKDIAGILQRQYAKVVREAKAHTFCDVVNLPKGEI-HYESSLNPVCDEEGICQFVICITRDITAQIE
EKTKIEEKQSLLEYNNDSIISIDSIGRVTYANPATYEIFGYRYEELNNKFIFEFINKEYEKDFQILFKGSMQ--GKAKQSKKYVHKEGYELYISLRTIPI
-IVNGEIVGVYIVTRDVTRQVLNEMRTEYLAYYDQLTGLMNRISCTNKLNTFLNE----SVNFALVFIDLDEFHRINDTFGHKEGDKVLQKVTECLSNLK
IEDMHLFREHDDQFVMLIENITKECVEEVAKSILKNISEYFVIEEEDVYLSASIGIVMAPADGEDEKILFQRVDAALEKAKEKGKGHYHFYCSGLDCERE
QRFIIENQLHRAIEKNEFFLYYQPQINIETKKIASMEALIRWENKELGFVSPNQFIPLAERTGFIIKLDEWVVNQVCQQLREWLNKGYEVVPIAVNISAR
HFRSITLIEMITRALNKYNVSAHLLAIEVTEGALIHK-DISKRVLLQLKEQNLKIHLDDFGTGYSSLSYLKTYPIDTLKIDRSFMEGIHIDERDTNITAA
IIHLAHTLELNIIAEGVEKKEQIQFLKEKNVKLVQGYYYSRPLSKYDMENMYY-------
>tr|C2XP54|C2XP54_BACCE Sensory box/GGDEF OS=Bacillus cereus AH603 GN=bcere0026_4530 PE=4 SV=1
------------------------------------------------------------------------------------------------DDET
FKYIYVNKIGMDHARLGKECY-GKT---FAEVLPEHTARLLQGQYAKVMREARAITFCDVISVPTGDI-HYESSLNPVCDVNGTCQFIICITRDITAQVK
KKVEIEEKQSLLEYNNDSIISVDSIGRITYANPATYEIFGYRYEELKDQFIFQFINKEYEKTFQIIFKNALQ--GRAKQAKKYIHKEGYELYISVRTIPI
-IVNSEIVGGYIVTRDVTRQVLNEMKTEYLAYFDQLTGLMNRISCTNKLNEFLAE----NKEFALVFIDLDEFHLINDTFGHKEGDQVLKKVTECLRDLK
IEDMHLFREHDDQFVMLIENITREYVEEVAQIILKKISGHFVIEEEDVYLSASIGIVMAPEDGMDEKMLFQRVDAALEKAK-KGKGYYHFYCSGLDCERE
QRFIIENQLHRAIEKNEFSLYYQPQINIETGKIASMEALIRWENKELGFVSPNQFIPLAERTGFIIKLDEWVVHQVCEQIREWLNKGYVVVPIAVNISAK
HFRSITLIEMITRALNKYNVPPHLLAIEVTEGALIHK-DVSKRVLLQLKEQNLKIHLDDFGTGYSSLSYLKTYPIDTLKIDRSFMEGIYKDERDTNITAA
IIHLAHTLGLNVIAEGVEKAEQIQFLKEKNVKIVQGYFYNRPLSIYDVENIYF-------
>tr|A0A073JSJ3|A0A073JSJ3_9BACI Diguanylate cyclase OS=Bacillus manliponensis GN=BAMA_15985 PE=4 SV=1
------------------------------------------------------------------------------------------------KGNS
FRYIYINDIGMKHTGLNESCF-GKT---FQQALPEDVAKVMQEQYEMVINGKEAVTFRDSITLPKQEVLHYESSLNPIFNEYGACEYIVCITRDITAQVH
EKIEIQERQSLLEYNDEAILSVDVNGYIMYVNPAIHKVLGYSEWELKNKCIFSYVKEEARRAFQSIFEEALK--GKA--SYKYEHRNGYELYISFKTVPI
-IVNKVVTGVYIIMQDTTKQVLQE--LKYLAYYDQLTGLLNQSSYMEMLAQFLQ-I---KKDFTLIMMDLDEFNLINETFGHESGDDILKKVSRRLRELS
PKGAHLFRDDGDKFVILLEHIEQLKIEKFVTRLLQGLQQHFVVNGYEVFLNAAIGIVKSSDGGKDEQTLLKWVNIALERAK--GKGNYSFYCNKLNMERS
RRFILENKLHKALERSEFVLHYQPQVNIETEEIIGMEALLRWYNEDFGNVPPSEFIPVAEKTGFIIKIDEWVLEEVCRQLREWINKGYKPVPIAINISAK
HFRSSKLIDTVIRVLEMYSIPRNLITIEITEGA-LMNTKQSEAVLQQLKENELNIHLDDFGTGYSSLSYLNKYPIDTLKIDRSFMKEVNSSEKGEKITTI
IIHLAHTLGLNVIAEGVEEIEQIQFLKDKNAVYAQGYYFNKPLSVHEVEMKYL-------
>tr|A0A073K9Y4|A0A073K9Y4_9BACI Diguanylate cyclase OS=Bacillus gaemokensis GN=BAGA_09645 PE=4 SV=1
------------------------------------------------------------------------------------------------RNQT
FEYVYMNERGMNYSGLDERCY-GKN---FEEVLPAEIAQILQLQYVMVMKKRKAHTFCDVVTLPTGETLHYESSLNPICDANDICQFIICITRDITAQIH
EKGEIEEKQSLLEYNDDSILSLDPSGKIMYANPATYKIFGYRDQELKSNFIFQFLNKHYEKPFRNIFKGALK--GEAQQAQKYIHKDGYELYLSIKTVPI
-IIKGEIIGVYIVMRDVTKQVSNELKTEYLAYYDQLTGLLNRISCSNKLNALLNT----KKEFALIFIDLDEFHLINDTFGHEIGDRVLKKVTNRLKNIY
VKDMYLFREHDDQFVMLIENINKDQVEGIVQTTLKKINDCFVINEKTVYLNASIGIVMVPEDGTDEKTLFQRADGALEKAK--GKGNYQFYCSGLNVERE
KQFMMENRLHHALEKNEFSLCYQPQINIMAEEMVGMEALLRWKNEELGYISPGEFIPLAERTGFIVKIDEWVLNQVCKQIREWMNKGYKVVPIAVNISAK
HFRSVTLIEVITRALEAYNVPPHLLTIEITEGALMHK-DLSKNVLLRLKEKQLKIHLDDFGTGYSSLSYLKTYPIDTLKIDRSFMKEVHVDVRDANITAA
IIHLAYTLGVNVIAEGVEEAEQIQFLKEKNVLLAQGYYFNPPLSVDKVENIYF-------
>tr|A0A090ZC93|A0A090ZC93_BACMY Diguanylate cyclase domain protein OS=Bacillus mycoides GN=DJ93_3046 PE=4 SV=1
------------------------------------------------------------------------------------------------PNQT
FEYVYINERGMNYARLDESCY-GKS---FNEVLPLDIARILQEQYVTVMKNGKSHIFRDVITLPTDEILYYESSLNPIYDTDHICQFIICITRDITAQVE
ERNEIEHKQSLLEYNDDSIISLDSFGEIMYANPATHEIFGYRHQELTTQSVFQYINKKYEKSFRSIFNETLQ--GKTRQAKKYVHKDGYELYVSMKAIPI
-IVNDEIIGVYIITRDVTKEVLNEMKTEYLAYYDQLTGLMNRISCTNKLNELLNE----NKKFAFVFIDLDEFRLINDTFGHKEGDQVLKRITNCLRDLH
VENMHLFREHDDQFVILIENITKEQVEEIVQMVLKKISRHFVIEKEDVYLSASVGIVMAPEDGIDEKTLFRCVDGALEKAK--GKGNYQFYCNGLNNERE
QQFIIENQLHRALEKKEFFLCYQPQINIKTEKMASMEALIRWENKDLGYVIPDKFIPLAERTGFIVKLDEWVMNQVCKQIREWLDKGYEVVPIGVNISAK
HFRSVTLIEMITRALKKYNVPSHLLVIEVTEGALMHK-DFSKRVLLQLKEKNLKIHLDDFGTGYSSLSYLKTYPIDTLKIDRSFMEDLHRDERDANITAA
IIHLAHTLGLNVIAEGIETAEQVQYLKEKNVFLAQGYYFNRPLSICDVESIYF-------
>tr|W1SG97|W1SG97_9BACI Sensory box/GGDEF family protein OS=Bacillus vireti LMG 21834 GN=BAVI_14324 PE=4 SV=1
------------------------------------------------------------------------------------------------NGPK
FRYLFVNESGMKKAKLSIEAL-GKT---LQEVLPVENAKSLQQNYEKLLRKKEIVMFEDKFFFEGGRKIYGETILTPVYNDEKSISYIVAVTRDITKWSI
EKNKIIESESIVNNNLDAIFMISPEGKILEANPAAALMTGYSEKQMTNRNIYDLIIGKDLEKFKTLLEKTCS--GYA--DCKIMHRKGNQLIVQIKTVPI
-VVHEQINGLYVMLKDLSDQAKNMEMIRFMAFHDQLTGLLNRKALHEHLNEHIFSPSYKTNEFALITIDLDRFKFLNDTLGHLAGDQILRRVSERLLRFQ
NEHCFVYRVGGDEFNILLLNSGSKKANIFVRKVFSAFSQSFYLNSQEYFISPSIGISMYPNDGKDAEMLIKNADEALYRVK--GKAHYQFYRTEMNSSVT
NVVTLETHLRKAIDKAELSLYYQPQVNTETGEVKNFEALLRWKDREFGHISPSIFIPLAEDTGLIISIGYWVIENACRQIKSWNDNGYDDIHVAINISPK
QFQHPNLVQFIQSMIKKYDIQASSLGIEITEGA-MNDTKETIPILKKVKELGISISVDDFGTGYSSLNYIKQFPIDVLKIDQSFIRDILLDEKDAAITST
IIHLGKSLGLEVVAEGVENQKQVEFLSNAECYKIQGFYYSKPLPGDEIEKRFL-------
>tr|A0A098EW68|A0A098EW68_9BACI PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Bacillus sp. B-jedd GN=BN1002_01490 PE=4 SV=1
------------------------------------------------------------------------------------------------EGPV
FRYLFANKSGMRMAGITEDAI-GKT---FQEALPEEISSQLQREYKKALLNGGSTTVFDSASVSGGELFFGETLLSPVSSADGKVSYIVAITRDVTDYVN
EKNNIIESGSIVDNNMDAIFSISMEGRILEANPAAAKLTGYEEMELLTYSIYDLVSDADFSSFAKLVENTGN--GMA--DCRFSHRNGHPLTLHIKTVPI
-IVFGDIKGIYVIIRDISEQSKNVEMIKYMAFHDQLTGLLNRRALLDKLNEQLFSPERTRKEFALISIDLDRFKYLNDSLGHLVGDEILKKASSRLLECQ
NERCFVYRQGGDEFIILLLETSRKATAFFAQRILSMFKRSFYFNSQEYYISPSIGISMYPNDGKDAETLLKNADEALFRVK--GRAHYQFYRTEMNSTVT
NFLAIETHLRKAIEKKELYLHYQPQIDLGTGKARSFEALLRWNSSELGAISPGVFIPLAEDSGLIISIGNWVIDQACKQIRAWNRKGYTDFRVAVNISPK
QLQQPNFISYLKSALEKHNVQPSSLEVEITEGS-MQNKNEAAPALQSIKKLGVTISVDDFGTGYSSLSYLKQFPIDVLKIDQSFVRDIIGNEKDAAIASA
IIHLGRSLGVEVIAEGVETSLQAEFLTSEGCHKAQGYFFSRPVSPEIAEEHYL-------
>tr|K2GQA5|K2GQA5_9BACI Diguanylate cyclase/phosphodiesterase with PAS/PAC and MHYT sensor(S) OS=Salimicrobium sp. MJ3 GN=MJ3_03962 PE=4 SV=1
------------------------------------------------------------------------------------------------MGGS
SVLMGTAISGMHYTGMASATY-EMK---EPLGEPAAEAAI----------------------------------------NQGVLGYFIGVIYYNRKMED
AHKNYSLSSSIIKSANDAIIITDKEGTILSWNKAAEKIFGYTSEEIIKQPLTTIMPEKYRTAHERGLAEYLNTKTVT--QLEGLHKTEGVFPVELSLSAV
--HEQRDVYFTGIIRDISERVSHEKRISELVYKDDLTKLPNRRMLHDHLSMSLQQAAKNNTSVSILFLDLNRFKSINDLYGHNMGDELLKSLTERLKTLL
PLEAILSRNSGDEFIIVYPEATSYQVSSFTRNIAQALGSPFLLREFKIYTSLAIGVSTYPEDGEIADELIKNADMAMYQAK--GDNIACFFTESMNEEVS
RKTLLEIGLQQAHESGELTLYYQPQVNTNTGEVIGMEALLRWEHSELGRISPAEFIPLAEESKLIIPIGEWVLKEACKQFREWLDEGYELGHVAVNISSV
QFQNRELPEVIGKILEETQLPPEYVELEITESV-VQNTKEAIPIMKELKQMGVKLSLDDFGTGYSSLKYLKDFPLDTLKIDKSFIQTVHESEKDQAVIDT
IIKMGNRLALNVIAEGVETSGQLDYLKERQCLYYQGFLFSKPISKEDVQRLLF-------
>tr|A0A024P5N0|A0A024P5N0_9BACI Cyclic di-GMP phosphodiesterase Gmr OS=Halobacillus karajensis GN=gmr_2 PE=4 SV=1
------------------------------------------------------------------------------------------------VWLS
AVFMGVAVSGMHYTGMASASF-YLK---GD-GLSAEGPSI----------------------------------------DPGSLGWVIAVIKLDAEMET
TNTRLEVANAIVETANDAVVTSDDKGMVMSWNKAAENIFGFKEEEMVGISLLNVMPEKYRKAHELGIKRYNQTSRAI--ELEGLHKNGSTFPIELSLSTV
--EDGGRTYFTGIIRDITERVESEQRIRDLVYQDDLTQLPNRRALYDQLAESIERV---DAPIAVMFLDLDRFKQVNDVYGHRIGDLLLYEGAARTKSCL
TEKDLLARQSGDEFIMVLPERGALEVKQIAQSILEKIAAPFVIDGREIYISGSIGICLYPEDGSTPDLLIKRADTSMYQAK--GGNQCCFYTKEIDESLS
RKLQLENGLRKALERDEIEVYYQPQVDTFSERITGFEALARWNHPELGFIRPDEFIPMAEDTKLIVPLGEKVLLEACHQFSRWLAAGYNLDRIGVNLSAI
QFRDPSITATVSHVLKETNIRPEHLELELTETI-VQDSKEAIPVMQHLKGMGVQLALDDFGTGYSSLSYLKDFPLDTIKVDKSFIDAIHQSEKDRAVVDT
LIRLAAKLEMNVIAEGVETESQLNYLRIHGCTEYQGYVFSAPLKKGEAGKLLE-------
>tr|D7E131|D7E131_NOSA0 Diguanylate cyclase/phosphodiesterase OS=Nostoc azollae (strain 0708) GN=Aazo_0695 PE=4 SV=1
------------------------------------------------------------------------------------------------TGVG
IQLI----------SL--SLF-N-F---FVTKFSENQPKK---------------------------------------QQNNNLNFTESEDKEISECQR
IQPELQKLLATLESATDAILIVDSLDKIVGFNKKFLEM--------WDIPALMITSGNYKQALRTAIKKLDNPYLSIDIGENILFKDGRIFNPFYQ-QQY
--KYKKNIGQVWIFRDITAEKLASNIINYESLHDILTNLPNRLLLKNLLIDALTKVS-HNHSLGVCFLDLDRFKKINDSLGHGIGDKLLQMVAQCIKKSL
RSDDIVARWGGDEFIILLPEISEYNIDLIQERIFAAFKQGFKIDNYHLNISPSIGIALYPQHGEDGETLIKNAEAALSFVK--GRNNYKVYQAAINSQAT
ELFILENSLYNALERQEFKVYYQPQVNSSTGEITKMEALLRWQHPELGLIPPATFIPIAEETGLILPISEWVLKTACLQNKAWQQTNLSSLSVAVNFSGR
QFQQPNLVGIVEQVLCETKLAHRYLELEITETVAMQDVELTQKILRQLDEMGVTISIDDFGTGYSSLSYLKDFSIHALKIDQSFVQDLANKDHQTAITTA
IISLAHGLNLSVVAEGVETQEQLNALRILQCEIMQGYFFSHPLSAEEATRMLT-------
>tr|A0A074LKT1|A0A074LKT1_9BACL Uncharacterized protein OS=Tumebacillus flagellatus GN=EL26_13405 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------DTQSTIRLETRFLSANG---WIDATGSPVLDESGNLTHVICIGRDISERKL
AKQLLEESESLFDHHPDAIFSLDLEGRLVSLNQALEELLYRPFLELVSEADRELSAEK---------F-RLAKLGLT--ETRLLNVRGEEVEVQALKLPI
-FVNGEVVGVYGMIKDVTAFNQMQNGLKRMAYHDDLTGLPNRRWMTQAIEDSIVRAQKNRTISALLYLDISRFKNINDSFGHAFGDRFLIKVAERLQECS
ARGLVVSRLIGDEFTVLISDRKTADIMDTLSYLLHALGQPFDIEGKEMFMTPHVGVALYPTHAHDAETLLKHAGAAVHKAK--RQHIEIYSH--SDRDPA
ELFSLESDLRIAVANKDFVLYYQPKVNIQNGSVDSVEALIRWMHPERGVVSPGDFIPLAEETGLIIKLGEIALELACQQAKAWQDE-GHPLRVAVNVSAM
QFHQEDFVEQVLDKLRQTGLPPKLLELEITESVVMGDVERVKDTMTHLSQLGISISIDDFGTGYSSLQYLNLFPIQTLKIDRSFVQSIESRTSQAPIVST
IIAMAQTLGLEVIAEGVETEEQVDFLWKHGCNLVQGFIYFRPMPAEQVISKII-------
>tr|H0BYZ8|H0BYZ8_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. NO-1 GN=KYG_13141 PE=4 SV=1
---------------------------------------------------------------------------------------------------M
LRCQFANQGYAAYNGHTTESIIGLT---VQEAIGDKAWEAIQPHVERSS--REHVKYTREQTLPNGEVRMIEVNLIPHFDAD-QQLGSFVLITDITERWR
AERTVRQSEKFTEAT-DEAIVFHRDGIITDGNEALTRLTGYALTEVVGLSIFNFISPEWRAVALDYTRS-----GR-EDEVTIRHKDGHAIPVEVVGKTM
--PLHHADYRIVVVRDITARKQAQEREAFIALHDSLTQLPNRHFLMEQLSQVLSLARRRHGRCAALFLNLDHFKTVNDSLGHHAGDQLLCNVAERLRQGV
RDADVVARLGGDEFVVVLTDVASEDAAVVADKLLAAMHGVFTIDQLPLTISPSIGIALYPEHGHSADQLLRCADAAMHHAK--GRGNRQFYDPSMDASAL
DVLRHERLLREAIATDAFELHYQPQVRLSDGALQGLEALVRWRHPERGLVGPDEFITFSESRGLITPIGRWVMREACRQLKEWQDQGLAMVPVAVNLSAI
EFRQRDVAAEIATVLRETGLAPHYLEIELTESVLMHQTGQVLDTLNALKALGVGISIDDFGTGYSSLAYLKRYPIDKLKIDRSFVADTPGNADDVAIVTA
IIQMGHSLQLKTVAEGVETAEQVGLLTGLGCDLIQGFVVSEPMDASRASDWLR-------
>tr|K0I5Z3|K0I5Z3_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. KKS102 GN=C380_21440 PE=4 SV=1
------------------------------------------------------------------------------------------------SDAL
LRCQFANQGYAAYNGHSTESILGIT---VQEAIGDKAWQAIQPHVDRCS--GERVKYTREQTLPNGEVRMIEVNLIPHFDGV-QQLGSFVLITDITERWR
AEREVRQSEKFTEAT-DEAIVFHRDGLITDGNEALTRLTGYSLQEVTGLSIFNFISPEWRATALEYTRS-----GR-EDEVTICHKDGHAIPVEVVGKTM
--PLHHADYRIVVVRDITARKQAQEREAFIALHDTLTQLPNRHFLMEQLSQVLSLARRRHGRVAVLFMNLDHFKTVNDSLGHHAGDQLLRNVAERLRSGV
RDADVVARLGGDEFVVVLTDIQTDDAAMVADKLLDSMHGVFTVDHLPLTISPSIGISLFPDHGASADVLLRCADAAMQHAK--GRGNRQFYAASMDASAL
DVLHQERLLRDAIARNDFELHYQPQIRLADGTLQGLEALVRWRHPERGLVGPDEFITFSESRGLITPIGRWVMREACRQLKVWQDEGLAPVPVAVNLSAL
EFRQRDVAAEIAAVLLETGLAPQYLEIELTESVLMHQTGQVLDTLNAIKALGVGISIDDFGTGYSSLAYLKRYPIDKLKIDRSFVADTPGNTDDVAIVTA
IIQMGRSLQLQTVAEGVETQAQIDLLAGLGCDLIQGFVVSAPLDAEATERWLR-------
>tr|C5T7A6|C5T7A6_ACIDE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax delafieldii 2AN GN=AcdelDRAFT_2786 PE=4 SV=1
------------------------------------------------------------------------------------------------SDAL
LRCQFANQGYAAYNGHTTESILGLT---VQEAIGDKAWRAIQPYVERSV--GEHVKYAREQTLPNGEVRMIEVNLIPHFNAR-EQLGSFVLITDITDRWR
AEATVRQSEKFTEAT-DEAIVFHRDGVITDGNEALTRLTGYSLAEVLGRSIFNFISPEWRAVAYEYTRG-----GR-EHEVTIRHKDGHTIPVEVVGKTM
--PQLHADYRIVVVRDITARKEAQERETFLALHDTLTQLPNRRSLMEQLGKALSMARRRKSQVAVLFINLDHFKTVNDSLGHHAGDQLLRDVAERLRQGV
RETDLVARLSGDEFAAVLTDIASADAAMVADKLLEAMRGVFTVDQLPVTMSPSIGISMFPCDDATAEGLLRCADTAMYHAK--GRGNRQFYQPGMDASAK
DVLQQERLLREAIAEGAFVLHYQPQIRLADGSLQGFEALVRWRHPERGLVGPNEFITFSESRGLITPIGRWVMHEACRQLKAWQDEGLAMVPVAVNLSAL
EFRQRDVAGELAAVLHATGLQPQFLEVELTESVLMHQTGQVLETLQAIKTLGVGVAIDDFGTGYSSLAYLKRYPIDKLKIDRSFVTDTPQSTDDVAIVTA
IIQMGRSLQLQTIAEGVETPAQMDLLRQLGCDLIQGHAISPPMDAEAAHAWLQ-------
>tr|J0K3H7|J0K3H7_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_06615 PE=4 SV=1
------------------------------------------------------------------------------------------------SDLL
LRCLFANQGYAAYNGHSTESILGLT---VQEAIGDKAWQAIQPHVERSS--GEHVKYAREQTLPNGESRMIEVNLIPHFEDA-RQVGSFVLITDITERWR
AERSVRESEKFTEAT-DEAIVFHRDGLISDGNEALYRLTGYALHEVVGLSIFNFISPEWRAVALDYTRS-----GR-EDEVTIRHKDGHAIPVEVVGKTM
--PFHHADYRIVVVRDITARKQAQEREAFNALHDSLTQLPNRRHLMDRLSQAL--AR-RQGRLAVLFVNLDHFKTVNDSLGHHAGDQLLREVADRLRHCV
GEADMVARLGSDEFVLVLTGIHADDAAQVADAVLQAMRTVFTVGHLPLTMSPSIGISLFPDDGASGDALLRCADAAMQQAK--GRGNRQFYQPGMDLRAM
EVLQQERLLREAIADNAFVLHYQPQICLKDGALRGFEALVRWRHPVRGLVGPSDFITFAESRGLITPIGRWVLHEACRQLKAWQDEGLALVPVAVNLSAL
EFRQRDVAGEIAAALEATGLAPQYLEIELTESVLMHQTGQVLGTLQALKDLGVGISIDDFGTGYSSLAYLKRYPIDKLKIDRSFVMDTPDSADDVAIVTA
IVQMGRSLQLQTVAEGVETTEQMALLRSLDCDLAQGHLISVPMDAPAIRQWLL-------
>tr|B9MCG8|B9MCG8_ACIET Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax ebreus (strain TPSY) GN=Dtpsy_0486 PE=4 SV=1
------------------------------------------------------------------------------------------------SDAL
LRCVFANQRYAAFSGQTVQSIIGKT---VREAIGEKAWQEILPYVQRAL--GESVQYTREYAGPQGRAHMLEISLQPHFGVREAMVGAFVLINDITHHWE
AERAVRQSEKFAIAT-EEGLAFHRDGRILDANEALQRMVGYSLAELVGQSIFDFALPEYRALAVEYTRR-----GS-EKELAMRHKDGRVIPIEVVGKTM
--PQQEGDYRVVVVRDITARKQAQEQARFLVLHDTLTQLPNRRHLMMQLARMASAAQERQTRAAVLFIDLDHFKTVNESLGNQAGDQLLIEIARRLQDGV
KATDFVARVGGDQFIVLLPDLANAAAAEVADALLARVRAEFAIGGTPLSLSPSIGISVFPDDGYSPDELLRRADAAMHHTK--GRGTRMFYEPGMEGQPT
ELLQQEHLLREAVFQGAFALHYQPQVRVADGRLVGFEALVRWRHPVRGLVGPDEFIPLAESRGLITPIGRWVLHEACRQLKAWHDEGLPRVPVAVNLSAI
EFRQRDVVGEIAQVLQSAGLAPQYLEVEITESALMQQADHTRTTLQALQALGVAVTVDDFGTGYSSLAYLKRYPLDKIKVDRSFVTDTPADSEDVAIVTA
IIQLAHSLQLQPVAEGVETAEQLALLRRLGCELAQGFGIAPPMDAQRAREWLR-------
>tr|A0A0A1VH38|A0A0A1VH38_9BURK Predicted signal transduction protein OS=Acidovorax sp. MR-S7 GN=AVS7_02511 PE=4 SV=1
------------------------------------------------------------------------------------------------GTAL
LRCVFANQRYAQYSGMAVDALIGKT---VRDAVGERAWQQILPYVERAL--GEAVQYTREHVQDDGEARMMEITLMPHFDRDGHMVGAFVLINDITHHWA
AERAVRQSEKFAEAT-EEGIVFHREGIILDGNEALQRLTGYPLDELVGHPIIDFVEPGHHEAVREYVQH-----GR-EDELAIRHKDGHTIQIEAVGKTM
--PQAGGAYRVVVARDITARKQAQARADFLAGHDTLTQLPNRRSLMQQLARTLADAQHWRRRAAVLFIDLDHFKTVNESLGHEAGDQLLCEMARRLQGSV
EAGDFVARVGGDQFVAVLPDIRNTAAATLADTLLERVRAVYAIDGTPLSLSPSIGISVFPEDGYAPDELLRRADAAMHRAK--GRGTRQFYAPGMEGQPT
EILQLEHQLREAVFQEAFVLHYQPQVEVSSGRLVGFEALVRWQHPQRGLIGPDEFIPVAESRGLITPIGRWVLREACRQVKAWHDEGLPRVPVAVNLSPL
EFRQRDVAAEIAAVLHATGLEPRYLEIEITESALMWHTDQTRETLQALQHLGVGVAVDDFGTGYSSLAYLKRYPLDKLKIDRSFLTEAPANGDDVAIVTA
IVQLAHSLQLQPVAEGVETAEQIDLLRRLGCGLAQGFGISQPMDAERTRAWLQ-------
>tr|F4G4I6|F4G4I6_ALIDK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K
------------------------------------------------------------------------------------------------SAAL
LRCRFANQRFADFMERTADGILGTT---ARDILGEQTWQQILPCVQRAL--GETVQHLCQQAGPDGRMRMLEFSLRPQLEPRGATPGILVLVNDVTERLE
AEQAVRQSEKFAEAT-EEGLAFHRDGRILDANASLQRMTGYTLAELVGRSIFDFIQPEYRALAQEYTRR-----GR-EYELAMRHKDGHAIPIEAVGKTL
--PQQQDEYRVVVVRDITARKQAQERARFLALHDPLTQLPNRRHLMLQLARTVATAQERRKRSAVLFVDLDHFKTVNESLGHEAGDQLLCEVARRLQEGV
KATDFVAHVGGDQFVVLLSGLRGAAAAAAADALIERIRAVYTIGETQLSPSPSVGISVFPDDGYGPDELLRRADAAMQQAK--GRGTRLFYTPDMEGQPA
EVLQQEHLLREAVFHDALELHYQPQVQVASGRLVGLEALVRWRHPQRGLVGPDDFIPLAESRGLITPIGRWVLREACRQLKAWHNEGLALVPVAVNLSAI
EFRQRDVAGEIARVLQETGLEPQYLEVEITETTLMQHAEHTRATLQALQAMGVAVTVDDFGTGYSSLTYLKRYPLDKLKVDRSFVADTPADGDDVAIVTA
IVQLARSLQLQSVAEGVQTTEQLTLLQSLGCELAQGFGIAPPMDVRRTRAWLH-------
>tr|A9BUE4|A9BUE4_DELAS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Delftia acidovorans (strain DSM 14801 / SPH-1) GN=Daci_1202 PE=
------------------------------------------------------------------------------------------------NDTL
LRCRFANINYARNFGLTPAEAIGKT---VREIVGEAVWQLIAEHVERGL--GEHVRYEREVPQPDGPPRHIESLLMPHFEHG-QLQGAVVQITDVSHHHH
VAQKVRDSEKFTEVT-TEAIVMHRDGLIIDGNEALSRLAGYTLDELTGRPILDYICPEFRLYALQYMRS-----GR-EDDGAIQHKDGHRIPVEIEAKTM
--PAEGEPYRIVLVRDITLRQLAQERMDFLAQHDQLTQLPNRVRLIQMLRQALSLASVKRRALAVLIIDLDHFKTINDSLGHQAGDLLLCEVAQRLRGSV
RAHDLVARVGGDEFVVVLTDDPDQETETQASHLQRIIEAPCAIDGTPLVISPCMGIAMYPGDGKNAEELLNRAESAMHMAK--GRRNLQFYAPAQDGQAT
QMLMQEQQLRGALERGEFELYYQPQTFTADGRLAGFEALVRWRHPQRGLVLPGEFIGFAEARGLISAIDHWVLREACRQARQWQDEGLAPVPLSVNLSAL
EFRQRDMAREVAQVLEETGLEARWLHIELTESTLMHTSGQVQDTLQALQALGVGLAIDDFGTGYSSLAYLRRHPINQLKIDRSFIADVPDSEDDTAIVTA
IVQMGHSLHLDIVAEGVETPAQLALLRELGCGMMQGYLVAPPLPAERARAWQL-------
>tr|A0A096EF32|A0A096EF32_COMTE Diguanylate cyclase OS=Comamonas testosteroni GN=P368_09110 PE=4 SV=1
------------------------------------------------------------------------------------------------EDAI
LACRFANARYAEHFGHTMQTIVGMD---VRDIVGELVWTQIEPYLDSVAVDTQTLRYTRQVENETGRLQHIEAVLRPHEEKG-VLKGVVALMTDVSHHHL
ATQQIRDSEKFAAIT-TEAIVLHRDGIITDGNDALARLVGYSLGELRGTPVLDYVAPEARLRALQNMRS-----ER-EDESVIIHKNGQLIPVEIEACTM
--PGEKDRHRIVLLRDLTASLQTRQHMDYLTQHDLLTHLPNRARLNHLLADAIARAAGEQSRLAVLSLDLDQFKAVNDSLSHQAGDLLLCELAKRLRSTV
GAQDIVARTGSDDFVVVLPDNPGLETEALLTRLRATAEAPYLIEGTQLVISVSVGIAMYPKDGKCPASLLSNAEAAMQMAK--GRSFSQFYTPALESRAT
RMLMQEQMLRNAVERGEFELHYQPQTLMQTGELSGFEALVRWKHPHRGLVSPDEFIGFAENRGLIAAVDRWVLYQACRQARAWQQQGFPAIPVAVNLSAQ
EFRQRDVVKEVAQALADTGLDACYLHIEVTETTLMLSGNQMQQTLHALKALGVGLAIDDFGTGYSSLAYLRKHPIDRLKIDRSFVTDLPHNPDAAAIVNA
IVQMGRSLHLEILAEGVESTEQLQLLREMGCAMMQGFLVSAPLSAEQASAWMS-------
>tr|A2SCH7|A2SCH7_METPP Diguanylate cyclase/phosphodiesterase OS=Methylibium petroleiphilum (strain PM1) GN=Mpe_A0304 PE=4 SV=1
------------------------------------------------------------------------------------------------QAEQ
LRCLFANRPYALTFGRDEQSILGLP---IAEVIGEAALRRIRPQLDTVLVEQRAVAYERQLVRADGRTQWVEVHLLPQLATDGRLIAFFVLISDISRHRL
AEQAVRESEKFMQAS-AEGIVFHKGGVITDANAPIGMLVGYGLDELMGRRTLDFVAPDQVSKVAAVMSS-----GQ-ETESALIDKSGRRIPVEFIVRTM
--MRGDERLRMTIVRDLRDRHAAQAHIHHLAHHDALTGLPNRLAFMAEIDQLMARAAASREALALLFIDLDHFKRVNDSLGHLAGDELLKTVAQRIGAVL
RASDVVARFGGDEFMVLIGGGPREDVADVARKLLAAIEVPLDAVGRSISVTPSIGIAMFPGDGITPAELIKHADTAMYRAK--GRATYQFFDPTLASNAY
AALVLEGELAQALERGEFVLHFQPQVRAGDGVLVGAEALIRWQHPERGLLLPDQFIPLAEQQRLMLPIGTWVLHEAARAARRWHDDGLCAVPVAVNLSAV
QFQAPDFVSTVAQALAGAGLPGRLLELELTERMLMDELPEVSGRLAQLKALGIRLSVDDFGTGYSSLGHLKSLPIDKMKIDRSFVVDLPEARGSVAIARA
IIQMARSLGITVIAEGVETEAQRAFLAREQCDELQGEAISPSLSLQAFEAWAG-------
>tr|A0A014MRJ7|A0A014MRJ7_9BURK Uncharacterized protein OS=Comamonas aquatica DA1877 GN=AX13_15695 PE=4 SV=1
------------------------------------------------------------------------------------------------PHDL
LRCIWATATYARLLEMPSQELLDKA---PQSYLSPCTWNEWKCELERLADSQTPLRFARQQAVPTQ--------LVADVQQG-VVRAIVVIPLQDLSHTD
ALQMVQDSDRYAHAT-REAIIFFRQGRVFDANPAAIALTGYPLHQLLDRPVVHLLPHVLRAEAQSLIDQ-----GT-EHETRLLHHGGQELDVEIAVHLL
--PEDGDTYGMLVLNDITERKRAEAEVYFLANHDPLTRLPNRQGLMQQLRQVLLQAERTQQHIAVLYVDLDRFKDVNDSLGHDAGDKLLIDAARRMRSKV
HPDDLVARLGADEYVVVLASPLTCQPDCILRELRFALNKPYVLPKEAVNLPASIGVSIYPEDGSTAEELMLNASAAMEAAK--GQGHLQYYNAHLQVRPS
RLLVQDRLLREAVANDGLVLHFQPLWNLATNRLEGFEALVRWQHPQRGLLPPAEFIGFAEARGLISLVDRWVMRAACKQLRAWRNAGLPPVVVAVNMSAT
EFNQRTLVEEVQLVLADTGIDPQWLEIELTETTLMKQSEHVLQTLQALRQLGVRLSIDDFGTGYSSLAYLKRYPLDKIKIDRSFVKDTPQDADDVSLIQA
IIQMGRSLNLRTVAEGVETKAQWDMLQAMHCDLIQGYYLARPMAAEEALRWQQ-------
>tr|A0A084XXM6|A0A084XXM6_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-01 GN=gmr_8 PE=4 SV=1
------------------------------------------------------------------------------------------------SEAR
FGCIYTNAAYHKISGLSFDETLGTR---WSRAIHPDDRQRVLAEWGEAVRGLAPFQTEFRFLQSDQSIVWTRVNSGAMSDGR-ALHGRVETVEDITERKA
AEFVLQAAEEERERAGDAVLCTDLAGNVSYLNLVAEAMTGWSYKEALGRPLAEVFRGNTREPAASPAERAIRQ-NRTGLDCLLIRRDGLELAIEDSAAPI
--HNRDGRGAVLVFHDVSESRAMVLKMAHLAQHDFLTGLPNRALLTERLAQAIGLAQRRHKQVGLVFLDLDYFKNINDSLGHAIGDQVLQSAAARLTAAV
RASDTVCRQGGDEFVLLLAEIEQLDAALVAEKLLEAFAAPHLIGKHELHVTLSIGISVYPADGNNVDSVLQNADTAMYHAK--GRNNYQFFRPDMNTRAV
RRQFLESGLRRALKQGEFRLHYQPQIDLASGAMNGAEALVRWLDPELGVVCPEQFVPVAEECGLIVPIGRWVLREACRQTRCWLDAGLRVVPVAVNISAV
EFRQKGFLQGVAMILEETGLDPRYLELELTESILMQNAECSTSVLEGLKAMGVQLAIDDFGTGYSSLSYLQRFPIDTLKIDRSFVRDITIDADDATIVSA
VIGMGRNLKQRVIAEGVETREQLAFLRSRQCDEGQGFLFSHPLSLADFADLLA-------
>tr|A0A011PG49|A0A011PG49_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-92 GN=gmr_18 PE=4 SV=1
------------------------------------------------------------------------------------------------SEAL
FVCVYSNAAYHKISGRSFAQTLGTN---WNSAIHPEDRQRALAAWHAAARAQVPFHSEVRFLREDGGVVWMRLNAAPLSVGG-M--AQVQTVEDISVRKS
LEFVLRAAEEEKERAGDAVLSTDILGKVSYLNRVAEAMTGWSREEALGRPLAEVFTGTTRQAAANPAQRAIEE-DRSGLDCVLVRRDGVESAIEDSAAPI
--HNRYGQGAVIVFHDVSQSRAMTLKMAHLAQHDVLTGLPNRLLMTERLSLAIGLAQRHGRQVALLFLDMDRFKHINDSLGHVVGDELLQSVAGRLVACV
RATDTVCRHGGDEFVILLADIDKQDAAHVAEKLHLASALPHLVGGHELHVSLSIGISIYPDDGSDANTLMGNADTAMYHAK--GRNTYRFFRADMNARAV
RRLLVEGRLRRALKEDEFVLHYQPQIDLVSGAMTGAEALIRWRDPELGLVYPGEFITIAEECGLIVPIGRWVLREACRQVQAWRDAGLPAVPVAVNISAV
EFRQRDLLDGVALILKETGLASRYLELELTESVLMDHAESSVAVLEALKAMGVSLAIDDFGTGYSSLSYLKRFPIGTLKIDQSFVRDIATDADDATIVSA
VIGMGRNLKQRVIAVGVETPAQLAFLRTHQCDEGQGFELSYPLSAHDFTRLLL-------
>tr|N6Z208|N6Z208_9RHOO PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thauera linaloolentis 47Lol = DSM 12138 GN=C666_08340
------------------------------------------------------------------------------------------------LAAR
LYCPD-----AAELLMPPERFMGRR---AEDVGLPEEVGH---ALRRVREEVQSMEY--ALDLP-HGRRWFSAKLSPMIDDDGVFAGAIAIVRDITALKA
SEQRFRRLFNIA------VQGYDTERRVVFWNAASEALYGYSRDEVLGNTIDDLIIPASRDEMRRLHRDWIEH-DRPIPEFELRNRDGKAVSVFSSHSLL
--NNEHGE-LYCVDVDLRALKEAQAQLLRAATHDPLTGLPNRLLVRDRVDQALAFAVREQALVALMFIDLDHFKIINDTLGHGVGDRFLQEVSQRLASCL
RDSDTVSRQGGDEFLVVLPGLHDGAVAAVAQKIIEAMQTTFSIGDHALTCSCSIGIALYPEDGGDFDSLLLRADTAMYQAK--GRNAFRFFTAQMNADVH
ERLAMQNHLRHAIQQGEFELHYQPQIDLVTGHVSGAEALLRWHSAVLGTVPPARFIPLAEESGLIIPIGEWVLREACRQAQQWREQGLGPMVMAVNVSAL
QFHRSDPVEMVGRILSETGLPAECLELELTESLLVQDGGATLETLRRLKALGLRIAIDDFGTGYSSLAYLRRFPIDKLKIDRAFVRDIACDPEDAAIVNL
IVDLGRILKLKTIAEGVEDPEQLAFLGARGCNEVQGYLFARPMPGADFAAYLD-------
>tr|W0SKD5|W0SKD5_9RHOO PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_03577 PE=4
----------------------------------------------------------------------------------------------------
--------------------------------------------------NRGGREMEVRRRKKNGEIFWARLQLSLLKDDDGQPNGIIGFLSDITERRD
AAE----QLRIFEQSDEAILITDAREKIVSVNPAFTRITGYSADEVIGETPRKFRSGRHDAAFFAKMWERLLGTGYW--WDRRKDGEIYPKWLSIGSVR-
-DAKGEITHYFSIFTDITDRKRAEGRIHHLAYFDALTGLPNRVQFNRLADQALMASKRKEGFGAVLFIDLNRFKPINDTLGHVVGDKVLQETANRFRSCL
RGADMVCRLGGDEFAVGLFEIASDHAANVAHKLLAALDDPIVIGGRELKLGAAIGISIFPEDGMDTETLLRQADIAMYRAK--GPDGLSFFSEDMNQRAV
DRLNLEAGLRRAIDRDELLLHYQPKVSIETGAIIGAEALVRWRHPERGLVPPAEFVPVAEESGLIVHVSNWVLEAACRQIRQWMDEGLPAMHIAVNLSAR
DFSS-SLPARVQELLERHKIGAEWLELEITEGMLMHHTAKVVAMMDEITALGVALSLDDFGTGYSSLSYLKRFPIDTLKIDRSFVISIPDDVDDCAIAGA
IVSMSKQLKHNVIAEGVESGDQLAFLKSLGCDEIQGYLFSPPVPAETFAAMVR-------
>tr|D3P4J1|D3P4J1_AZOS1 Diguanylate cyclase/phosphodiesterase OS=Azospirillum sp. (strain B510) GN=AZL_c02770 PE=4 SV=1
------------------------------------------------------------------------------------------------TEEQ
YRYLRVNPALAEI-------Y-GYA---SPEDLIANLTDIACQLYDLMARQDRVLSFEARVFRRDGSIIWISESARCVRDPAGRIRYYEGTVQDITERKQ
HEE----KITVFDSVADGILIVDPELTVQAINPAYEIMTGFQREELLRRPLVLFAPGSHERDFIDAIWTTARQSGRW--TSFRHSGDAFAAALSVTSVR-
-APNGVLEHYVLTIADISQRKSQEHQIRYQASFDRLTDLPNRWLVCERLEEAIIRAQRGKSKVAVAFLDLNRFKQVNDTLGHHAGDELLKLVARRMRNCT
RMTDTVGRLGGDEFLIVAPDAADSAGARLVEKVLYSMSEPFSVHNQELFCGASIGIAFYPDDGDTADQLLRNADLAMYHAK--PEHKYVFYDSGMRERSG
FTLGLESDLRRASGGDEFELHFQPKIDLAGNITIGAEALIRWRHPVRGMVSPAEFIPLAEETGMIWEIGAWTLIESCRRLADWIERGLPIPSVSVNLSPR
QFQDARLVGFVRSVVEAAGIPAERLELELTEGAMIGDIEKAVTILNGLKDIGVRLSIDDFGTGYSSLAYLKRFPIDTLKIDRSFVRDIVKSTTDPAIVGT
IVNLAESLGFDTIAEGVETHEQAEMLRQQRCTRIQGYLISRPLPVDQFEAFLR-------
>tr|Q30T73|Q30T73_SULDN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) GN=Su
----------------------------------------------------------------------------------------------------
-------------------------------------------------EDKSPYSIIHRIITKDKKLKYVEERCVHKLDESGNVVKSIGTVHDITERVE
HEK----ELNVFKYSSDGIVITDKNNNIVSVNKSFEKLTGYSKEEIIGKNPKLLSSGWGDEEFYKNMWSSLLSNDLW--WDRKKDGSLYAIEQTIICVR-
-DKNQDIVNYIGMSRDITEAKNKEEKIHQLAFYDFLTKLPNAKLFQQEVEAYIKSTHYNNETFAILFLDLDNFKWVNDSLGHQIGDLLLIEIAAKLKEII
SQDSIISRLGGDEFVILAP-YENLTISQLANTILCSVKDPIKVQNREVNVSWSIGISLYPQNGENYNDLLKNADAAMYESK--GKNTFRYFNDMMNQDAM
YRLELDTKLRYAITNNSFFLNYQPKYSFEHGKTIGVEALIRWIDKDLGFIAPDKFIPIAEESSYINEIGSWVMKQALNDLKIINSKLSSPISISINVSGK
QLEHESFYDEARTLLKESGIEPSLVEFEITETSIMQNIDHVVDILKKIKMLGVKISIDDFGTGYSSMSYLKKLPIDTLKIDREFIKELEIDEDSKSIVNA
IIALAKSFKLTTVAEGVENEEQKLILDGLNCDMTQGYLYSRPLSLDDLLAFLS-------
>tr|B6BGA2|B6BGA2_SULGG Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Sulfurimonas gotlandica (strain DSM 19862
----------------------------------------------------------------------------------------------------
-------------------------------------------------TNRCGYHVTHRIVRKNGEVGFVEERCEHEFDNDGNVLRSIGTVHDITKQKI
AQN----ELEVFSKMSDGVVITDANQSIIKINESFTKITGYTNEELIGMTPKAFSSGWHDEAFYKKMWDDIKQNGQW--IDRKKSSERYIAEMNIIALH-
-NDDGILTNYISITNDISKKKEQEKLIHNLAYFDSLTDLPNRVLFEERVVSRIPFSKRHDKKMALLFIDMDNFKNVNDTLGHFMGDMFLIEVSNIIKNSI
REQDTLARLGGDEFTVLLEDINSMDIVPIAEKIIAAFNNPVLIESKELYTGISMGISLYPDDGKSYNELFKAADTAMYQVK--GKNNFQFFKQSMNEKIT
ERLFLENSLRNAIGNNELFLVYQPKINLETKRVYGMEALIRWRHPEIGLIRPDKFISISEETGQIYNIGLWVAKQAIIDTKALHE-AGHILTVSINVSSK
QLENEKFIDDICCVVNEIGIDKSYVELEITESHIMSNIDKALKILNELSDKGFKLSIDDFGTGYSSLSYLKKLPAQTIKIDRSFVLDIYKDEDDRSIVAT
IIAMAKALGKDVIAEGSETQEHIDTLKYLHCNKVQGYFFSKPIEIDEFKEFVD-------
>tr|L8B148|L8B148_9ZZZZ Hypothetical diguanylate cyclase phosphodiesterase (Fragment) OS=uncultured microorganism PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------ADKRGYHVTHRIVRKNGDIGFVEERCEHEFDINGNVIRSIGTVHDITEQKK
AQN----EVEVFSKMSDGVVITDADQRIIKVNEAFTKITGYTNEELKDKTPKAFSSGWHDNEFYQKMWDEINHNGQW--IDRKKSSERYTAEMHIIALY-
-NDEGTLTNYISITNDVSKKKEQENLIHNLAYFDALTELPNKALFEERVVSRMPFTKRHDKKMALIFIDMDNFKNVNDIFGHLMGDIFLIEVAKTIKSTL
KEQDTLARLGGDEFAILIEDVSSMDMIPIAEKIITAFKKPIIIEEKEVYTGASMGVSIYPDDGESYEKLVQAADTAMHQVK--GKNNFQFFTQNMNEKIT
ERLFLEYGLRNALSNNEIFIVYQPKVNLETKKVYGMEALARWKHPELGLVQPDKFIAISEETGQIYSLGLWIAKQALIDTKALHQ-AGHILIVSINVSSK
QLEDEHFVDDICSLVDEIGIDKSYVELEITESHIMKNIDKALLILNELFFKGFKLSIDDFGTGYSSLSYLKKLPAQTIKIDRSFVLDIDKDEDDKSIVAT
IIAMASALGKDVIAEGSETQEHIDALKYLHCYKIQGYFFSKPIEIDEFKKFVD-------
>tr|K1Z8E9|K1Z8E9_9BACT Uncharacterized protein OS=uncultured bacterium GN=ACD_74C00196G0001 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------GDSFGNREF--RIIRPDGAERYMHTEAEVKRDEHGRAVHLMGIIQDITEAKH
ATQ----QLNVFENSIEGIVITDADGVIQRINRAFTDITGYGAQEVIGQNPRILKSDRHGEGFFVEMWRGLVETGQW--WNRRKDGEIYPEWLIISSIR-
-DVQGNIVNYVGVFHDMTEIKLHEEQLRYQAHHDALTGLPNRVLFHDRLGVAMAHARRDENKVAVLFLDLDNFKRINDSLGHTVGDLLLKEVALRLVRCL
REIDSVARYGGDEFIILFQGVEQEDVLLAAQRIIEGLAPVISIQGQEFYLTVSLGIAFYPEDGQDQDTLIKNADTAMYRAK--GKNTYRIFTPAMNKRVT
EWLAIENSLRRALDRKEFFLLYQPKVDLNTGSIVGVEALIRWRHGDGEIISPADFIPMAEDTGLIVEIGDWVLGQACADLGEILGKGYG-IKMSVNLSPR
QFRQDNLLGKIRATLSAAGIGPEGLIFEITEGSVMENEQKAIVLLGELRGMGAGISIDDFGTGYSSLYYLKQLPIGELKIDRRFVRDIMGRGDNVAIVAA
IIAMAKSLNMRVVAEGVETGEQLHFLCRHGCDQMQGFLFSKPVAMDVLLEMLD-------
>tr|E3DQU7|E3DQU7_HALPG Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halanaerobium praevalens (strain ATCC 33744 / DSM 2228 / GSL) G
------------------------------------------------------------------------------------------------TENK
LQIKNLNQAAVRLLGWEQEELTQKF---ISTIIAEKDREIWS-KFKNEKLEYLPQGFMSRTLKKNGTIINCRWNNIIIPKRK-NKFEIISMAQNVSYSLK
REM---EMVKAINETDNWVVITDKRGIIEYANTTVEEITGYKKEEVIGQNPSIFKSDKHSNQFYQKMWNKIRA-GEV--------------------IK-
-DQNQKIINYISVGRDITQNEKLKRKIEYISNYDIQFGLPNRKSIKNKMENLIGLK--AKSKLAILVLNINNIKYLNDIYNNSQTEKDLINLLADLINKI
DRENYLAYLGGNNFALAVDNLNSNEIYKLAEKILDIFTDTIDYNQESFMLNARIGISIYPDDCISSQNLLSNAEIALINIK----NDYAFFDQEMNQEIK
KFTKMEAKLDKAIKNDEFVIYYQPYYKGADHSLYGMEALIRWQNPQQGLISPAEFIPILENSQLIKKVGLIVISKVVNSIKHWLAKGYQVVPVSINLSAK
QLEDNTHLKNIYRLILNSGINHSLIKFEITESSAMNDVNYSLKVMNKMKEKGFAISIDDFGTGYSSFSYLQKFPIDYLKIDISFIRNMTLSKDGQNIVES
IINIAHLLNLQTIAEGVEKKSELDILNKLTNDYIQGYYFDRPMPKSDIEKMYI-------
>tr|M5E133|M5E133_9FIRM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Halanaerobium saccharolyticum subsp. sacc
------------------------------------------------------------------------------------------------NQKK
IKIIDLNQYAVELLGCEKNEIIKEF---IPTIISEKDRNLWF-KWQEGKMNCLPDNFRSHLIRNDGTTINCIWNNVEIKKDE-NTIEIISIAKNLTKNVE
HEI---EMFKAINETDNWVVITDAEGVVEYVNTTVKEITGYSRDEVIGEKPSLFKSNKHNDRYFKNLWETIKA-GKV--------------------IK-
-NNNNEIINFISVGRDITQNKKLLKQIEYISNYDLIFGLPNRSYIESKIDNLIEANK-REEKIAVLVIKFDKIKHLNDIYNNSNNERTLINLIADLINKI
DENNSLAYLGGDNFALIINDIKSNEIYNIVKKILELFTDTINYNKETFMLNSRIGVAVYPDDSKNAKNLVSNSEVALINIK----NDYAFFNQEMNTQIR
KFNKMEARLDKAVKNDDFLVYYQPYYKRSDHSLFGMEALLRLKDSDQGIIYPSKFIPILESSQLIKKVGLIVISKVVNSLKKWIQSGYQVVPISINLSPK
QIEDSKHLQKIYQIIDNSGINNSLINFEITESSAMSDVDHSLKVMKKMKEKGFSISIDDFGTGYSSLNYLQKFPLDYLKIDISFIRNMTKNDDGKNIVES
IINIAHLLNLKTIAEGVEKEIEVKELNRMNNDYIQGYYFSYPMPESKIGKIYR-------
>tr|M5QSM6|M5QSM6_9BACI PAS, GGDEF and EAL domain-containing protein OS=Anoxybacillus sp. DT3-1 GN=F510_1562 PE=4 SV=1
------------------------------------------------------------------------------------------------KGPR
FRYVRVSPTALHLANLSEEDM-GKC---IEDVYDEHVANHLNFQYIRACKTKSLVSFRARMNVKD-DIRFAESTLIPILNEKNEVSYIVACTREITDMLK
KEEQLEEAQSLFTHSQEAFILFDLFGHIIRVNEETERLFGLQQKDIVGKTLFDVIPVYKENIHQTL-----QREGKPE--PTITAIDGETIPVQIDILPF
--PYETNRTELMIIKPSEPIVVHEKEK----------VYIDRTEFMEKLTDLLFT----HEGVAVLLVDIHQFKFINSFLGHENGDELLKQVGMRLHNTI
HPKAMWTRITGDQFAIALSYGSQEEVKQFANMIKEVLIEPYSIAQQQIRIGMHIGVGYAYDAKLCAETLLNNAEKALYFAK--GTNVVKSYEPHMSNAFA
RKIQLENALPLAVENNELFLLYQPKINVRTRS-CQVEALVRWKHPQFGFVSPAEFIPMAEETNVIYDIGKWVLRQACRDLAFLRQHTTGCMKIAVNLSAK
QLLDEQLFEDIQHILQEEGCDASCFIFEITETTMIKNPEHVAKTLERLKQLGFSIAVDDFGVSYSSLEYLNRFPIDEVKIDRSFVQNIVNHDKSKEIVSA
IISLAHNLQLTVTAEGVETAQQAQFLIEKQCEQLQGFYFSRPVSLEQLPSTIA-------
>tr|B7GKV6|B7GKV6_ANOFW Multidomain signal transduction protein (Contains PAS, GGDEF and EAL domains) OS=Anoxybacillus flavithermus (strain DSM 21510 /
------------------------------------------------------------------------------------------------EGPR
FRYERVSPAALHLASLTDKDI-GKY---IEDIYDHHVANHLNEQYMKAWETKSFVTFRDRMNV-E-GMRFAESTLIPILNEKNEVTHIVACTREITDVLQ
KEEQLEEAQSLFTHSQEAFILFDLFGRIIRINKEVERLFELRKEEIIGKTLFDVIPAYKENIEQTL-----AREGKP---LTITAKDGEMIPVQIDVLPF
--PYETNRTALMMIKPIEPIAVNQKEE----------TDTERTEFIEKVTDLLFT----HEGVAVLLVDVYQFKFINSFLGYENGNELLNQIGIRLNKVV
DPHTLWTRISGDQFAIALSYDRQDEVKQLANVVKETLQEPYTIGNQSIRIGVHIGISYAYDAQLCADTLMNNAEKALYFAK--GTNIIKAYEPHMSNVFT
RKMQLEHALSSAVKNKELFLLYQPKVNFHTRS-FSVEALVRWKHPQLGFVSPAEFIPMAEETDAIYDIGKWVLRQACRDVAFLRQSVAGCMKIAINLSAK
QFLDEHLVEDIQHILQEEGCDASCFILEITETTIIKNPEQVVKTLERLKKLGFSIAVDDFGVSYSSLEYLNRFPIDEVKIDRSFIQNMINNEKSKEIVSA
IISLAHNLQLTVTAEGVETEQQAQFLIEKQCEQLQGFYFSRPVSLEQLPNTIV-------
>tr|M8DQM5|M8DQM5_9BACI PAS, GGDEF and EAL domain-containing protein OS=Anoxybacillus flavithermus AK1 GN=H919_03882 PE=4 SV=1
------------------------------------------------------------------------------------------------EGPR
FRYERVSPTALHLASLTEKDI-GKC---IEDIYDHHVANHLNEQYTKATQTKSLITFRDRMNV-E-GIRFAESTLIPILDDNNKVSYIVACTREITDMLQ
KEEQLEEANSLFTYSQEAFILFDLCGRIIRVNHEMERLFGMQKEEVVGKTLFDVIPVHKENIEQTL-----EREGKPQ--TTITALDGETIPVQIGVLPF
--PYEEERAELMIIKPIEPIALKQQKE----------TYLEREQFIEKLTELLLS----YEGVAVLLIDVYQFKFINSFLGYENGNELLKQIGLRLHEAI
HCKAIWTRINGDQFSVALSYGTQKEVIELADVIKEALQETYVIDHQPIRIGIHIGISYAYDAQLCAETLLNNAEKALYFAK--GTNIVKRYEPHMSNAFA
RKIQLENALPLAVENEELFLLYQPKVNVHARS-CSVEALVRWKHPQFGFVSPAEFIPIAEETNAIYDIGKWVLRQACRDLSFLRQSATGCMKIAINLSAK
QFLDEQLVEDIQHILQQEHCDASCFIFEITETTIIKNPERVVTTLERLKKLGFSIAVDDFGVSYSSLEYLNRFPIDEVKIDRSFIQNIVNNEKSKEIVSA
IISLAHNLGLTVTAEGVETEQQAQFLIEKQCEQLQGFYFSRPISLEQLPNTIA-------
>tr|A0A023DSU5|A0A023DSU5_GEOTM Putative signaling protein OS=Geobacillus thermoglucosidasius NBRC 107763 GN=GT2_16_00460 PE=4 SV=1
------------------------------------------------------------------------------------------------AGPR
FRYVRASSHALYLANLTEKDI-GKC---IEDIYPKEMAAYLNKQYRKALETRKIVTYRDQVNIKG-EWRIAESMIVPVFTKDGTMPYMICFTRDITEQIA
REKQFEEIHSFLEQTHDAIVMFDLAGRVLRVNREAERLLGWSEKEVLAKKIADFLPGHHGKLQQSL-----QKRGQTQQEWVLTSLCGEQKEVDVKAMSI
--DYYGQSAQFLIIRDLSEQKSKEKKIEFMAQYDPITVLPNRNYLREKLNELLLR----DVSIAVLLVDVNRFQFINDFLGHSNGDELLKEVARRLKKIQ
SEQVFLSRIGDDEFAVVYTYNKKEEVNWLLKKLDRLLNEPYFIAGEKLNVTINIGVSYAHDADRSVETLLSNAGKAVYYAK--GVHRVVQYQSKLHDIFV
KRIRLENDLQTALENNEFSLYYQPKVNVQSGT-VSVEALIRWKHPQLGMVSPAEFIPIAEETNMIERIGKWVLQQSCDDLKTLHKSGFSALKMAVNLSAR
QFMDSSLKATVSNILTSADVPPSSFVFEITETTIMKEPNEVIRILQALKEQGIMIAIDDFGVSYSSLNYLNRFPIDAVKIDRSFIRDFHENRKGAEIVEA
IISLAHRLNLSVTAEGVETEEQVRFLLEKGCDEMQGYYFSRPVPLEQLPNVLM-------
>tr|A0A023CSU7|A0A023CSU7_GEOSE PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Geobacillus stearothermophilus NUB3621 GN=H839_03741 PE=4 SV
------------------------------------------------------------------------------------------------EGPR
FRYVRVSEDALPLANLTEQDI-GKC---IEDVYPQEIADHLNKQYKKALATREVVTYRDQMNVKG-EPRMAESMIVPIVKDDGTIPYMICFTRDITEQIT
REQQFAEIHLLLEQSHDAIVMFDLTGRLLRINKEVERLFGWSENEVMTKNIVHFLPKYRVQLLKSL-----QMIGQSEQEWLLTSLSGAEKEVTVKETTI
--DYHGQNAQFLIIRDLTEQKKKERKIKFMAQYDPLTELPNRSYLREILNDLLLH----VDNIVLLLIDIHRFQFINDFLGHENGDQLLKEVARRLKKLQ
SEQMFLARVGDDEFVAVYRYEKKEEAEWLLTTLDRSLNEPYFIAGEKLNVTVHIGVSYACDANHSAEGLLNNAGKAVYYAK--GINRVVEYESKLRDIFV
KRIRLENDLKTAVGNNEFSLYYQPKVNLHTGA-ISVEALIRWKHPQLGMVSPAEFIPIAEETSVIEEIGKWVLQQSCQDYKWLHSSGFSTLKIAVNLSAR
QFIDSSLKTTVANIFANANVPPSSFMFEITETTIMKEPNEVICILQSLKDQGITIAIDDFGVNYSSLNYLNRFPIDAVKIDRSFIRDFHKNEKGAEIVEA
IISLAHRLNLSVTAEGVETEDQVRLLAEKGCDEMQGYYFSPPVPLEKLPNVLT-------
>tr|V6T1S2|V6T1S2_9BACI Uncharacterized protein OS=Bacillus sp. 17376 GN=G3A_09380 PE=4 SV=1
------------------------------------------------------------------------------------------------TGYQ
FRYLFANENGLHHAGMAVSDI-GRT---MDEVLPLKHLNPLKKQYIKAVKEGVEVVFHDEVDMDNDNQVLGETLLTPIKDEAGEVKYVVAVTRDMTENFK
EKNRLIDSESLIDHNLDAVFSIDLKGEILDVNPAAQLLTGYTVKQLKSKRIKSLICESDLQPLKEVLSDTQM--GNS--DCRFMHRKGKILTVHLKTIPI
-VIDSEIKGMYIIIRDLSEQAKSTELIKYMAFHDQLTGLRNRRALLDQLDSLVKNEKKQKAEFALLFLDIDRFKYLNDTLGHLVGDQILKQVAHRLIEIQ
KENCTVYRQGGDEFIIVLERTGRKAAGEFAQKVLCRFNESFYFNSQEYYITPSIGISLFPNDGKDAETLIKYADEALYSVK--GKAHYQFYRSDMQSTGV
NIIALEAHLRKAIERDELELYYQPQINLLTNEISSFEALLRWNNSEFGFISPAEFIPLAEDTGLIIPIGNWVIDGACRQIKEWTEKAGKPIRIAINISPK
QFMQLDLVRVIKSSMEKYNIEPSLLEIEITEGA-MQDTKETILILKRLKDLGIKISVDDFGTGYSSLSYLKQFPIDVLKIDQSFIRDIKYNGKDAAIITT
IIHLGNSLGMEVIAEGVEEQSQVDFLTNADCEKAQGFFFAKPLRSQEAEEKFI-------
>tr|A0A0C2AD69|A0A0C2AD69_9ACTO Uncharacterized protein OS=Streptomyces sp. AcH 505 GN=HY68_38865 PE=4 SV=1
----------------------------------------------------------------------RFSKIINSSNAQFTTAINNMSKGLIILDRD
ARAIVCNDGYMRMYGLPAGVHPGCD---LRDILAFRVATGTFK-GDRLVREQRPERDEYTMQTGDGR--LIHVVNEPIPG-GGY----LSTHDDITASQQ
REESFK---LLFENNPIAMWVYDQDTLFLAVNDAAVSQYGFDRTQFVGR-LIIRPEDRNPFLLFVETIPVY-GENTWRHQRADGRIFEVVYSHALSY---
----EGKNARIVAAIDVTAQREAEKRIAYIAHHDKLTDLPNRSSFDEHFAAVITAAARLHSRIAVMCLDLDGFKQINDLKGHSAGDRVLRAIAERLAAVA
E-DAFVARVGGDEFTLICADNADTRSNDLAKRLIAAVHDDFPIDGQRFRVGLSIGIAVYPDHGTDTETLLGNADLALYRAKASRRGTAQYFNSEMDARVR
ERRAMAEDLRGALAAGEITLHYQPQVAMQHRQVVGYEALARWTSAKYGSVSPDVFMPIAEESNLIVEIGEWILRDACREAQSWQAP----KTVAVNISPR
QFQLVDLPNLIQMVLLDTGLPASRLELEITEGVLIEDFSRAVSVLRRLKNIGVEIALDDFGTGYSSLSYLHAFTFDRIKIDRKFVMDLDTSRHSQAIVRA
VIGLGQSLNVPVLAEGVETEAQFALLAREGCQAAQGYLTGRPLPPAEL------------
>tr|A0A0D7QFP0|A0A0D7QFP0_9BRAD Diguanylate cyclase OS=Bradyrhizobium sp. LTSPM299 GN=UP10_10075 PE=4 SV=1
-------------------------------------------------------------------------QALGRTNTRFDVAISNMSQGLCLFDAD
KKLVISNRQYQEMYDLPDDVVPGTP---LDRILQFYKDRGEASNLTQLMP----TQRKQDHELADDR--KIFIQRKPLPD-GGW----VATHEDITELKR
SEQLLA---EALNNMSQGLCMFDADQKIVVANARYGEIYRLDRDQIRPGTSLIL-YRREKGTNFADVAPELTKEAGEVRELVDGRVVAI-ARHIMA----
------DGGWLTTHEDITERARNEKKVAFLAQHDLLTGLANRAVFSEKLDEAARRLQRHGTTFTVLMLDLDKFKNVNDTLGHPAGDRLLVEVAQRLKSSL
RDTDVVARLGGDEFAIIQDNEKDAGAVGLARRIIGLIEQPFDLGGNKVNVGTSVGIAFAPEHGDTADVLLQKADIALYAVKSGGRNGFQIFRPELTEAAD
MQKSLESDLRDALSRNEFELHYQPMVDATTQTTCGAEAFVRWRHPSKGILLPDQFLPLAEAAGLMLPLGEWILRQACLDAAGWPSS----IRLAVNISAA
QFDGGDLLDSVLGVLVAAGLSPDRLELEIADDAVVQGN-AHLRTMRQLKNLGVSIVLDNCGAGYSAVSSLAGFPFDKIKIDKPIAQGLANRRDCAAMVSS
VLALADGLNVATAAKGVETEGQFEALRAAGVDFVQGYLFGRPVPVAEL------------
>tr|A0A099ILW7|A0A099ILW7_9BRAD Uncharacterized protein OS=Bradyrhizobium diazoefficiens SEMIA 5080 GN=BJA5080_03519 PE=4 SV=1
----------------------------------------------------------------------ENAAELKLINTRFDVAINNMNQGLCLFDAD
KNLVVSNNRYQQMYDLPDEVQPGTP---LQRILQHYADRGETSSLSQIMP----TQRQQDYALKDHR--QILIQRKPLPD-GGW----VATHEDVTEQKR
GEQMLA---QALNNLSQGLCMFDADQRIVVSNARYAEIYHLSGDQIGPGTSLIL-YRREKGTYFADVAPDLSKQLSEIRELADGRVVAI-ARHMMQ----
------DGGWLTTHEDITDRARNEKRIAYLAQHDLLTGLANRAVFSEKLDDAAKRSQRHGTTFSVLMLDLDRFKAVNDTLGHAAGDQLLVEVARRLSSSL
RDTDVLARLGGDEFAIIQENEKNEGAIALALRIIGLIEQPVDLDGHRVSVGASVGIAFAPEHGADAETLLQKADVALYATKSAGRNDFRIFQPEMTEAAD
TQKSMEGELREAMARNEFELHYLPVIDARTRAMTGLECFVRWHHPSKGVLAPFLFLGVAEQAGLMVPLGEWILRQACLDAAAWPAH----IRVAVNMSAA
QFHRSNVLDVVLCALVESGLSPERLELEIPDAALLDGNAAHLLTVRQLKNLGVGVVLDNCGVGYSAASYLQSFPFDKFKIDRAIVKDCTTRRDCAAVIAS
AVALARGLGVATVAKGVETPSQFEALQAAGVDFVEGYLFGRPVPNSEI------------
>tr|I2QPM1|I2QPM1_9BRAD Diguanylate cyclase (GGDEF) domain-containing protein OS=Bradyrhizobium sp. WSM1253 GN=Bra1253DRAFT_06585 PE=4 SV=1
----------------------------------------------------------------------ENAAELKRINTRFDVAISNMSQGLCLFDAD
KNLVVSNSRYQQMYGLPDEVRPGTP---LQLILQHYVDRGEASPLSRLMP----TQRQQDYELRDHR--QILIQRKPLPD-GGW----VATHEDVTEQKS
AERMLA---QALNNMAQGLCMFDAEQRIVVSNARYCDIYHIDPDRIRRGTTLIL-YRREQGTHFVDVAPELDKQLSETRELADGRVIAI-ARHMMQ----
------YGGWLTTHEDITDRARNEKRIAYLAQHDLLTGLANRAVFAEKLDEAARRSQRRGTTFTVLMLDLDRFKLVNDTLGHAAGDQLLIEVAQRLSSSL
RDTDVLARLGGDEFAIIQENESDEGAIALALKIIRLVEQPFDLGSNRVSVGTSIGIAFAPEHGIDAEILLQKADVALYATKSSGRNDFRIFQPEMTVAAD
TQKSMEGELREAMARDEFELHYQPVIEAGTRALTGLECFVRWHHPSRGVLAPSQFLDVAEQAGLMLPLGEWILQQACLDAAAWPAH----IRVAVNMGAA
QFHRSNVLDVVLCALVESGLSPERLELEIPDAALLGGNAAHLLAVRQLKNLGVGVVLDNSGLGYSAASYLQSFPFDKFKIDRAIVQGCTTRRDCAAVVAS
AVALGRGLDVTTVAKGVETPAQLDALLAAGVDYVQGYLIGRPVPNSEI------------
>tr|J6UIE5|J6UIE5_9RHOB Diguanylate cyclase OS=Rhodovulum sp. PH10 GN=A33M_3769 PE=4 SV=1
----------------------------------------------------------------------KATAEAHVAHARLLDALETVPVGLAFFDAE
DRFVLWNRRYDEIYEGSPEVFPGYT---FEERLRARVKADLIPSARW-IAERRAEASHHEQQLADGR--WVRIEERRTAD-GGS----MGIRVDITESKR
REESFR---L---------------------NDAAVEHYGYDRETFLTMSV----LDIRDPVDHQEA--ADEGDRVWRHRRADGNEVLIAYTRLLDY---
----QGHPAKLAALIDITEKWHDEARIRHLAHYDALTDLANRTLFRARLQRALDRSRDPDEGTALICIDLDGFKDVNDTLGHPIGDQLLKLVARRVSGCV
REEDTPARLGGDEFAVIQDGIRSEDASALASRLVAVISAPYMVEGHEITVTPSVGIATTFDGSCDLDDLLNHADMALYRAKSRGRSGHCFFAPEMDAELK
ARHALETHLRAAFERRDFAVHYQPWVDLADDSVSGFEALLRWHHPEHGPVSPAEFVPLAEKIGLIVPLGEWVLMQACADAVTWPER----VKIAINLSPV
QFRTGDIVETVRAALATSGLSAARLELEITETVLLEDNASNLATLHALRDLGVKVAMDDFGTGYSSLGYLRRFPFDKIKIDRSFVSELPGSHDCLTITRG
ITELAAGLRMTTIAEGIETPGQREVLRSLGCDEGQGFLFGRAVPASEV------------
>tr|A0A084XZU5|A0A084XZU5_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-01 GN=gmr_5 PE=4 SV=1
----------------------------------------------------------------------------RQASRLLLQAVEYSPVAI-VISRN
GEIEYVNPSFTQMTGFSRSEAIGQN---TRFLKSGETPPETYRQLW--------------------------------------------------DRHV
TETRLR---LVFEHSAEAIMINDHDNRILEVNKAFCRLSGYAPDEVRGQNPRLLSSGRSPPETYRAMWQ--ISTGYWRGEIWDRRKD---YPKWLSICG-
--SDGNIEHYIGIFSDISERKAAEEKISHLAHFDTLTDLPNRSNLQGRLEQALAAARRDSQPLAVMFLDLDRFKNINDTLGHHVGDSLLLEVSKRLMASV
RESDVVARLGGDEFVVVLTGA--AA-ERVAEKILKALSQPYHLDGQKLHTTSSIGIAVFPGDGESVDILMRNADAAMYHAKSAGRNNMQFFTASMNQAAS
DRRQLEEDLHLALQKNQFILHYQPQVDEL-RRVVAAEALLRWQHPAHGLVPPNRFIPLAEDTGLIVPIGHWVLETVCAQLQAWSVEARRDLQLAVNVSAR
QFRQADFVDQLRKVIEHSGANPLRLKLELTESLVLDNVADTIAKMDVIKQFGVSFSMDDFGTGYSSLSYLTRLPLDQLKIDRAFVSRLPDNQSDAVIAQT
IVTMGSSLGLKVLAEGVENEAQRQFLADHGCHGYQGFLFSRPLPVEAF------------
>tr|C7RNA9|C7RNA9_ACCPU Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Accumulibacter phosphatis (strain UW-1) GN=CAP2UW1_4053 PE=4 SV
----------------------------------------------------------------------ADISERREASRNLLQAVEQSPVAI-VINRN
AEIEYVNPSFTRVTGYSRLEAIGQN---PRILQSGEAPSDTYRSLWRLRADKGRFEWT--HQRADGSPVPVEVTLTPITR--GE----VILWRDISERRV
TETRLR---LAFEHSAEAIMVSDRDNRILEVNDAFCRLTGYAADEVRGSDPRLLSSGRTSAEEYRTMWQ--ISTGHWQGEVWDRRKD---YPKWLSIRG-
--AEGNTEYYIGSFVDISERKAAEEKISHLAHFDTLTDLPNRSNLQGRLDQALASARREGHSVAVMFLDLDRFKNINDTLGHHVGDALLLEVAARLRSSV
RDSDVVARLGGDEFVVVLTGA--AA-ERVAGKILKALSRAYQIEGHALHSTSSIGIAVFPADGESVEVLMQNADAAMYHAKSAGRNNVQFFTASMNEAAS
DRRQLEEDLHLALQQKQFVLHYQPQVDAQ-RRVFAVEALLRWQHPHHGLVPPARFVPLAEDTGLIVPIGQWVLETACAQIKAWSVDARRKLQVAVNVSAR
QFRQPDFVELLRQAIDNSGANPARLKLELTESLVLDNVADTIDKMNAIKLLGVTFSMDDFGTGYSSLSYLTRLPLDQLKIDRAFVCRLPENRSDAVIAQT
IVTMGRSLGLKVVAEGVETEAQRQFLDSHGCDGYQGFLFSRPLAVDAF------------
>tr|A0A011PCK0|A0A011PCK0_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-11 GN=gmr_4 PE=4 SV=1
----------------------------------------------------------------------ADISERQQASRNLLQAVEQSPVTI-VINRN
GDIEYVNPSFTRVTGYSRLEAIGQN---PRILKSGDVSAEVYETLWRLLAEKGRFEWT--HQRRDGAALPVEVTLTPITR--GE----VILWRDISERRL
TEQRLR---LVFENSAEAIMVSDRDNRIIEVNRAFSRLTGYSSDEVRGSDPRLLSSGRASADEYRTMWQ--ISSGHWQGEIWDRRKN---YPKWLSIRG-
--VDGAIENYIGSFVDISERKAAEERIRHLAHFDTLTELPNRSNLQGRLEQALAAARREGDPLAVMFLDLDRFKNINDTLGHHVGDALLLQVSQRLSGSV
RASDIVARLGGDEFVVVLARA--AA-ERVAAKILHALSQPYEIDGQAMHTTSSIGIAVFPGDGDTVELLMRNADAAMYHAKSAGRNNVQFFTASMNQAAR
DRRQLEEDLHLALQKDQFLLHYQPQVDSR-RRVFGAEALVRWQHPEHGLVPPGNFIPLAEDTGLIVPIGQWVLATACAQLAAWNDDRRRELQVAVNVSAR
QFRQADFVDQLHEVLQRSGADPTRLKLELTESLVLDNVADTIARMNAIKQLGVSFSMDDFGTGYSSLSYLTRLPLDQLKIDRAFVSRLPDNQSDAIIAQT
IVTMGRSLGLKVIAEGVETAAQCEFLERHGCHGYQGFMFGRPMPAGAF------------
>tr|Q47FU0|Q47FU0_DECAR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (strain RCB) GN=Daro_1542 PE=4 SV=1
----------------------------------------------------------------------ESIASRQPAHRL---------------MPD
GRVKYVLE---------------------------------------------------------GTPLRVIGTSQE-----------------VTAQQE
MLAQMQ---LAVQYSGEAILITDVKNKILTVNPAFTRLTGYTSEEAVGRDPSFLSAGRTMPEEYERMWN--IERGFWQGEIWDRRKD---YPKWMSIRG-
--EDGMIRYHVAHFTDVSSERAAEERLHHMAHHDVLTGLLNRLSLKGRLDQALAAARRDGSRVAVLFVDLDRFKVINDTLGHHVGDELLIEVANRLRDGV
RDSDVVARVGGDEFVIMLSGV--SAVAMVAEKLVFSVGQSYQIGGYDLYSTPSIGIAIYPTDGEDGDILMKNADAAMYHAKMAGRNNFQFFDAKMNEAAL
ERLNTEHALRRALANQEFCLYYQPVIDLASNRVASLEALIRWNHPEKGLLLPGKFIGIAEETGLIQPLGEWVLWAACRQLADFAAAGISGIKMGVNISAI
QMRNGNLPLLARGVIEAYDIDPRNLIFEITESVAMEQPTETVRILDLLNAMGVSVAIDDFGTGYSSLSYLRMFPINHLKLDRSFVEQIGEEIDGCVICDA
TIGLAHSLELKVVAEGVETQAQLDYLRSRGCDMVQGFLFSRPVPADEV------------
>tr|C1DA12|C1DA12_LARHH Sensory box/GGDEF family protein OS=Laribacter hongkongensis (strain HLHK9) GN=LHK_00129 PE=4 SV=1
--------------------------------------------------------------------------------RLTQYSVDHGVDLI-LWDLN
SRVRYANLRAQKQLGWHPHELYGRP---LSRIAPS-----------------DTLETS--FSCRNGQTLAVEVTASVLTT-EGD----GLIARDVSELKQ
AAAALA---NALQASGTGLY-------ELELATGAITITGAIRQRLDIRVPE-------QQPIPAALWLDARAFEHWQQEPHAPDRLETFRWVHARAAA-
--EDTAAARLVGTVNDVTDQKENEEQIERYAHFDALTGLANRHALYRRLGQAITSVHQHQHPLAVLFVDLDKFKTINDTLGHAVGDVVLREVAGRLSDFA
GPDDILARLGGDEFLLVLPGADE-AASEVAACILTAMSVPVRVDGRELPTTPTIGVSLYPRDGEEADDLIRNADIAMYQAKARGRNTFQLYTPDMNAAAA
ERLQLQGELRNAHLRGEIMLHYQPQIDVTDGHVVGCEALMRWKHPTLGMVSPGRFIPLAEESGLIITLGNWAIREACRQAMVWQRAGLPPLTVAVNLSGC
QFQQSNFTAVVADALADTSLPPQYLELELTESIVMHDVEQVIATLTELKALGVQLSIDDFGTGYSSLNYLKRFPVDLLKIDQGFVRDVETDPSDAAIVRA
IIALGKILNLRLIAEGVETQGQLDYLHAAGVDFIQGYYFSRPLPAEDM------------
>tr|B0UAD7|B0UAD7_METS4 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacterium sp. (strain 4-46) GN=M446_1993 PE=4 SV=1
----------------------------------------------------------------------ELQAARDRAHRMLENAIEAMADGFVMWDRD
DRFVTCNSRYRALYALSEPLRPGAR---FEDIIRYGAERGQYPQAGF-VRNVWDDHGTLERLLPGGR--WVLITERRTAT-GET----VGIRTDITALKA
ALEDLA---AALGNMSHGLLMADAAGRLIVANRRLAELLGTAPETLAPGESMIFAIGARCSLGRRALARQIAGAGTFKISGQDGRTLSIQR--P------
----MADGGSVAIYEDVTEQQQAEDRIRFLAQHDPLTRLPNRVLFRERLDAMMRAD--APDATALLYLDLDAFKNVNDTLGHPVGDALLAAVGARLGACV
GEGGVVARLGGDEFAVACAEGEA-AAQALATRIIAQLSAPYALAGRTVQVGASVGIAVSGPEARDADTLLRHADMALYEAKGRGRGLACVFEKSIAARLH
ERLALQSDLAEAVPGGQLVLAYQPVFDLAGGRVSGFEALVRWNHPVRGFVSPAQFIPIAEQTGQIEAIGAFVLDRACRDAAALPPG----IRVAVNLSPV
QLRAEDIVERIATALAESGLAPARLELEITETALMEDSERMVQLLERIRALGVRIVLDDFGTGYSSLSYLRTFPFHKIKIDQSFVREMTTRANSLAIVSA
IVGLADELGMATTAEGIETADHLDFVRKVGCREAQGYFLGKPKPILSA------------
>tr|N6ZMX7|N6ZMX7_9RHOO PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Thauera phenylacetica B4P GN=C667_17763 PE=4 SV=1
----------------------------------------------------------------------------ARSFDAL---IDSRQEATCAWRPD
TTLLTCNERYAELLGAEAASLPGTR---WIDSVPEAKRAEVNATIA--------LTTDRRLRQADGRTRWLRWLDLPVFD-GRC----VEIGQDITAHKE
AELRLR---QAVEQSPNTIVITDTEGRIEYVNEAFVRTTGYTADEAIGRNPRILNAGKTPAATYGDLWA--LRGELWRGEFVNTRKD---YTELATIKQ-
--ADGSISHYVAIKEDITERREAEARIRQLAYYDTLTRLPNRSLMWDRLRHAIAASERSGSGGMLLLLDLDHFKLLNDTQGHQAGDALLREVARRLRAAL
REEDTVARLGDDDFAIVVENLGEAHAEKIAEHLHRAVTAPCELGLGLYHVGASLGLTLFRGRAETADGLLKQAEVAVARAKDDGRNLIRFFSAAMQAVVA
ARAELELKLRAALAGNGFRLYYQPQLDRS-GRVIGAEALIRCFDADGTMISPAAFIPLAEETGLIVPIGEWVLETACAQLRAWQREPAAGLTLSINVSAR
QFHQPDFVGKVAAAIERSRIRAGGLKIELTESVVLGDIETTVLRMRQIKALGVRFALDDFGTGYSSLSYLKRLPFDQLKIDQVFVRDMEKDTSSEAIVRA
ILAISRSLDLEVVAEGVETAAQHELLLTRGCELFQGYLFGRPVPIEDW------------
>tr|N6YE15|N6YE15_9RHOO PAS domain-containing protein/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Thauera sp. 27 GN=B447_14404 PE=4 
----------------------------------------------------------------------------ARSFDAL---VESRREASCTWQPD
TTLLSCNARYAALVGRSPSELEGHR---WLDYLPEHERPATAAAIE--------LATDRSMHHIDGSIRWIRWVDLPVLE-GRC----VEIGQDITAQKE
NELRLR---QAVEQSPNTIVITNTQAQIEYVNASFTRTTGYAADEVLGQNPRLLNAGKTPPATYADLWA--LRGEVWRGEFINSRKD---YIELATIKQ-
--PDGSVSHYVAIKEDITERRAAEARIRQLAYYDSLTGLPNRSLMWDRLRHAIVASERSGMHGMLLLLDIDYFKLLNDTQGHKAGDALLREVAQRLRTAL
REEDTVARLGDDDFAIVVEGLGAAHAGRIAEHLHGCIAQPFDLGLGPYHGTASLGLTLFHGRANPAEAVLKQAEVAVDRAKHDGRNLHRFFSEAMQAVVA
ERASLELKLRAALAENRFRLFYQPQLDST-GRLIGAEALLRCFDTHGSMISPASFIPLAEETGLIVPIGDWVLQAACAQLRVWQAHVAGDLSLSINVSAK
QFHQPDFVAKVTAAIERHRVNAGLLKIELTESVVIGDIETTVARMKQIKALGVRFALDDFGTGYSSLSYLKRLPFDQLKIDQAFVRDMDDGNSSDAIVRA
ILAISQSLDLEVVAEGVETSAQHERLLQRGCVMFQGYLFGKPVPIEAW------------
>tr|N8VH60|N8VH60_9GAMM Uncharacterized protein OS=Acinetobacter sp. ANC 3789 GN=F975_00097 PE=4 SV=1
----------------------------------------------------------------------------RRS-QIL---LRNAHDGI-HVDAQ
GRLTEASESFFRMIGHTPEEVIGQT---PSYWDACYNKAEIQDLIK------ERFETFYYN--AQGEAYPVEVSLVRVHD-DYE----VF-ARDITERKK
AEENQR---IAAFDSQVGMLITDPNLKILRSNRALTEITGYSQQELIGQTPRILQSGTHDKKFYDTMWD--ISTGSWQGEIWNKRKN---YAQYILVRD-
--EKGQTTHYVASITDISAYKASEEKVRLLAFYDSLTKLPNRRLFLEHLEQSIQDAEMKKRLGILLCIDLDNFKALNDTKGHETGDHLLQEVAARLLECV
GANHMIARLGSDEFAVLLDQTSAQQAEMVAKRILQVLAQPYFFENSEYRSSASIGISLFGMQAENVQDPLKRADIAMSEAKNYGRNTYRFFDPLIQSQVQ
ERAEIDAGLRQALEKNQLVLYYQPQVNRG-QQMTGVEALLRWQHPTKGIISPALFIPIAEENGFIISLGKWVLETACQQLSQWAKHPKAKLSIAVNVSAS
QFARDEFVQDVIEILERTQAPAHLLKLELTESALVLGIEDVIAKMMVLKHYGVMFSLDDFGTGYSSLAYLKRIPIDQLKIDQSFVRDIVVNSNDAEIAKI
IIVLTKTFGISVLAEGVETEAQRDVLEKYGCYDYQGYLFAKPMPIHEL------------
>tr|A0A078MAD3|A0A078MAD3_9PSED Sensory box protein OS=Pseudomonas sp. 12M76_air GN=BN1049_01497 PE=4 SV=1
----------------------------------------------------------------------------RRS-QML---LRHASDGI-HIDER
GRLTEASNAFYQMLGYAPGELEGAH---LTDWDLSHSPAERAELFR------QTFETSYHH--RDGHSFPVEVTTARLDG-DGP----LL-ARDITERKK
ADEDLR---IRAFESQVGMLITDAELRILRCNQAFCRITGYTAEEVIGQHPTLLQSGRHDQQFYADMWA--IRHGAWQGEIWNKRKN---YPQLLSVSN-
--DQGQVTHYVASLSDISARKATEEQMRTLAFYDSLTKLPNRRLFIERLEQALEIAKRRQGYGALLVVDLDDFKTLNDTEGYHAGDHMLEQVATRLIRCV
PHKDAVARLGGDEFVVLLDHLSQQQAEQLGQQILQELTRPYQLGPNVYRGTARIGIAFFGGRFISSAEPLKRAELAMSQAKGT-NNAIAFFDPQMQAQVR
ERSEIDAGLRVAVEKRQFLLHYQPQVDDR-GELIGVEALVRWAHPTQGMISPARFIPVAEDNGLILPIGQWVLETACRQLTQWAGDDAAHLTIAVNISAR
QLAQASFVEQVLATLERTGAPARQLKLELTESALVHEIESIIDKMNRLKAHGVGFSLDDFGTGYSSLAYLKRLPLDQLKIDQSFVRDISSDGNSADIAHT
IILLAERMQIPVLAEGVETEQQRAALHERGCRQYQGYLFGRPAPIEEL------------
>tr|D5CTU0|D5CTU0_SIDLE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sideroxydans lithotrophicus (strain ES-1) GN=Slit_2024 PE=4 SV=
----------------------------------------------------------------------------QESLRTI---FETEPECI-KVDRN
GELVEMNQAGLAMLEAATLEARQKK---LIDYVAPEDQAAFLALHR------AEFKIT----GLKGTLHHLETHATPMPN-GNI----SLITRDVTASMH
AKQQLR---ITAFESQEGMLVTDAVGAILRVNQAFTRITGYTADEVIGKNPRILNSGRHDAYFYKEMWE--IRTGEWEGEIWNRRKN---YPEHLTVKD-
--AGGNVVNYVATLMDITASKASEEEIRNLAFFDPLTRLPNRRLLQDRLQQALASCGRSGKSGAILFIDLDNFKNLNDTLGHDIGDLLLEKVAIRLSSCV
REGDTVARIGGDEFVVMLEDLSDEQTESVGSKILASLNVPYQLGIHTYDNSPSIGATLFNDNHNSIDELLKQADIAMYQAKKAGRNTMRFFDPRMQQSLS
ARLALELELRKAIEKDQFQLYYQIQVDET-HRPLGAEALLRWMHPEHGLMAPAEFIPMAEETGLIVPIGWWVLETACTQLKAWEKDPLRNLVLSINVSAK
QFHQPDFVDQVQAAVDHYGIDPALLKLELTESILLENVDTTIKRMSALKKTGVGFSLDDFGTGYSSLQYLKRLPLDQLKIDQSFMQEITSDSSDMAIVST
IIAMAQSMQMGVIAEGVETEEQRQLLLRKGCNHFQGYLFSKPVPVEQF------------
>tr|Q21WS3|Q21WS3_RHOFT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T11
----------------------------------------------------------------------------RQALQSL---THHVPGVVFQYDGS
SCFPFASAGLHKIFRLSPEAVAQDA---APLFALMHPDDA-AGVAA------APWVDEYRVKFGDGTVRWLSSKAAPQKD-DGS----VLFVSDVTAHKQ
AEESLI---TAVEQSPVSIVISDPRGLIEYVNPMFEQVSGYRRAEVMGQNPRILSSHEKSEDEYREMWA--LAGDIWHGEFHSRRKD---FWEQAAIFD-
--DHGRPIHYLAIKEDITKRKAAEAEIEHLAFYDLLTGLPNRRLLNDRLQQVLAVGTRSRRHGALLFIDLDNFKNLNDTQGHEQGDVLLQQVAQRLNFCV
RECDTVARLGGDDFVVMLQDLSETQAEGVGQKILDALHQPYPFGHFTHHGSASVGVALFNASQDTVEELLKRADLALYQAKDAGRNTLRFFDPDMQAVIS
ARAEMEADMRLGLQENQFLLYYQPQVNHA-GRLIGVEALVRWQHPLRGLVAPAHFIPLAEDTGLILPLGQWVMEAACRQLQLWRTQAHAQLTIAVNVSAL
QFHGESFVSDVLATLARTGAPADRLKLELTESLLVKDVDGVIAKMVALKAHGVGFSLDDFGTGYSSLSYLKRLPLDQIKIDQSFVSDALSNPKDAALVRA
TVAMGRGLGMMVIAEGVETQMQRDFLEGEGCLNFQGYFFGRPVPVAEL------------
>tr|U5NBI6|U5NBI6_9BURK Signal transduction protein OS=Candidatus Symbiobacter mobilis CR GN=Cenrod_1518 PE=4 SV=1
-----------------------------------------------------------------------------ASQHAI---FDASPDAL-LVDTR
DIITMTNKQVESVLGYRGSELVGQP---IDIL-IPQRFRAMHATRK------MGVDVNAL--RRDGSECIVEIRISRVEP-QGW----FF-LRDQSERKS
AQEQLR---IVAFESQEALVVTDRLCRILRVNQAFTRITGFAADEVMGRNPSLLKSGRQGPEFYREMWA--IETGSWQGELWGRRKN---YPKWLAVRG-
--EDGQVTHYIGAHYDITAHKMAEAKIKELAFYDQLTGLPNRTLLADRLRQTMSSCLRDGTWGALLVIDLDNFKTLNDTLGHERGDALLKQAAIRLASYV
GEGDTVARVGGDEFVVVLAGRHRSATESTARKMLAALDAPYEMDGAVHHNTASVGVTLLGGESVSSEERMKQAELAMYRSKEEGRNGLRFFDPSMERAIH
VRVALEKDLREALESCKFQLYYQAQACDD-GTVLGAEVLLRWLHPQRGWVSPASFIPLAEETGLILPLGQWVLETVCAQLAAWGDDPLADLTVAVNVSAL
QFQQNDFVDRVLGALRSHAANPQRIKIELTESLFVDKVEEIVQKMYQLKGHGIGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDLLIDPNDAAIART
IVALAQSLGLGVIAEGVETQAQLDTLSHSGCHMYQGYLLSRPVPLGEF------------
>tr|Q2RP06|Q2RP06_RHORT Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Rhodospirillum rubrum (strain AT
---------------------------------------------------------------------------NRAVPSAKALMVW-------RAGPD
GRPLDPSQ-----FPQDPPARRGGAEA-WLNLVHPEEREAVLLLWRRALREGEEFEARYRLHRGLSGYRWALGQGRPLRGDDGEVREWIGTVVDIHDHME
AERTIALSELALDSADLGVWECTIATN--------QWWFSEAALRILGCPPDAETSIETVMGAIDARARTGRARDRMEGEFRIQRGGGRLGWIACSARLV
ADDGKAVTRMLGTLRDITKTRLQREKLYHLAHFDPLTGLPNRHEMITRTQATLASGGAAGGAGAILLLDLDGFKEANDTLGQATGDALLKRIAHRLVSSL
PADSLIGRVGGDEFLVVVPGVAEWTATRIADGLYDVLTVPFVIGDRRIPLSGRIGIALAPRDGTSAQDLMTHAELALQETKTISGCVTRFFSPRLHDEAR
ERQDMGLELRRATDNGEFELFYQPQIRLSDRAVVGAEALLRWRHPTRGVMPPAAFLHVLKRGPLAGEVGEWVVAKACADAAGLLNAGS-RIRMAVNLFSA
QFKAGTVDATVRRSLLESGLPAELLELEITEKVTLDRDEGILTCLKGLRDLGCGVAFDDYGTGYASLSMLKRYPLTRLKIDRAFVQHLAESPKDGAIVRA
VLSLGNTFGLSVTAEGIEEEEQEKLLLGQGCDEGQGYFFGRPMPLADFIQFLARVK----
>tr|U1L3E4|U1L3E4_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudoalteromonas spongiae UST010723-006 GN=PSPO_13177 PE=4 SV=
---------------------------------------------------------------------------SKGFAFNTQAVLQHVPIGLFVAKPT
GECMFANNALYRVLSLTNTDIV--GSS-YINAMHPDDRQKAIKHWYACTAKG-NFQFTFRSAAKTK-NKLLSIHAEPLI-ENKVITAYIGIVEDVTTINE
TERKLYLSQLAAKGASAGVWDW--SNNEVFYSTKFTELLGFDNL-AFGCDFTKQIHPDDIKQFKA--VHLADPFEAFDIEVRMYSAKQQELWFHIVGEAM
RDEKGNPYRMVGSMSDITEKKQSQQVIWHQANFDALTQLPNRNMFTDRLNQEIAKSKRSGDKFALLFIDLDHFKEVNDTMGHNAGDLLLVEVSERLKIIL
RETDTVARIGGDEFTALLCNIHNADVENIASKLIQAIEMPFYINNESIFISASIGITLFPDHSEKMEELLRFADQAMYLSKEEGRKQYRHFNKTLQEKSE
KAHLLTQELRLAVINQQLEVLYQPILSISDLKIHKAEALLRWHHPELGMVSPADFIPLAETSGMIIDIGNWVFQQAAEQVKKWQSNYDQHFQISVNRSPA
QFQSSLSKHDVINTLLQLSLK-HGICIEITEGLLLDDNEEIKETLKKFRSAGVAISLDDFGTGYAALSYLTKFELDFLKIDRAFVMNLESSAQNQALCEA
IIVMAHKLGLKVIAEGVETQEQLFILEAAGCDYAQGYFVSKPISHLLFERELASQD----
>tr|A4C531|A4C531_9GAMM Sensory box protein OS=Pseudoalteromonas tunicata D2 GN=PTD2_03801 PE=4 SV=1
---------------------------------------------------------------------------NLTLITDYQHLAEHVPTGIFEVDLA
GHCTFSNATFKQLLGLDDQLSL--GFS-YTRHFHPDDKMAVVKHWCRCIKKE-AFNYTFRVHLPEQVELYLTINAVPVF-KDQQLIAFIGCVEDVTELCL
SQQQLKDNQLALKSSGAGIWDW--LNDVVHYSAKFSDLLGFDNL-LFGTSWTDQIHPDDLDIFET--NHLDDADKPFNIECRLISQKKKVLWFTVVGEAL
RDEHGYPTRMVGSMVDITLKHQSQQMIWQQANFDHLTGLPNRNMFTERLKQEISESKRYQQKFALFFIDLDHFKEVNDTLGHGAGDQLLIEVAERLQLIL
RESDTIGRIGGDEFTALIPHINQCDIDSLAQKLIQTIELPFYIDGESIFISASIGITLFPDHSEKIDELLKFADQAMYRSKENGRKRFSYFTFAMQEQAD
HTRNLTQELHLAIIEQHFHVVYQPIMALPSRKITKAEALVRWDHPELGLISPADFIPLAERSGVIIEIGNWVFYNAAKQALKWQQEIDPSFEISINRSPV
QFQNPDPNADQKELLKNLGLI-KGICIEITEGLLLDDTQGIKDKLLYFQNNGMDISLDDFGTGYSSLSYLTKFDINFLKIDRAFINDLEHNQNNQALCEA
IIVMAHKLGLKVIAEGVESQRQLDFLAQAQCDFVQGYFISKPISAAAFEHQLKSPA----
>tr|D5VNR1|D5VNR1_CAUST Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Caulobacter segnis (strain ATCC 21756 / DSM 7131 / JCM 7823 / N
---------------------------------------------------------------------------AAARAFAFGAFVR--------DAPF
GADLALIAVS-RAWTAQAIGPSGAD---ASGIVGPDDRA----ALLACAYEGAFSRYLPAVAEDGSQRFWRTEFGACR-QEDGGVYAVMVTARDVTGYAE
SVLRAERDEMALELDDLLVREY--RTGEIFFAPGLRKWCVFK------DDPLEIVHPDDRQQCA-DVIASRKVGEARVFEFRLNRDDGVETWIRAVGKVF
VDQDGQPEKLVNLFKDITDRRRQTEAIETLAFKDPLTGLPNRALFQHRFNEAVSASETLGEMFGLIMIDVDHFKDINDTLGHDAGDVLLKRLAGMLRRAF
RSGDTVARLGGDEFAVILRGLRGADMMRPIQKLQELLQRPIEYAGRSFTATASIGAALHGDPEADPAHMIKNADIALYHAKEAGRNRSIVFEPAMRTELE
RRVELLRDVRAAVAANEFTLFYQPVVDIRERRVVGFEALMRWIHPEQGVLTPGHFMAAFEDQELSLRLGDLAFEQSLRQMRAWLDQGVE--RIAVNISAA
QFRSGRLAEEVQERLARWNVPCARLTIEVTENVYMGWGDLVSGNISRLHAAGVMIALDDFGTGYASLANLRQFPIDRLKIDKSFVQ----NAEDEAIVKA
VITLGASMGMKVVAEGVEDPDQLAALIRYGCDQIQGYHFGKPMPAEEVAGFLERFG----
>tr|Q9AAE7|Q9AAE7_CAUCR Sensory box/GGDEF family protein OS=Caulobacter crescentus (strain ATCC 19089 / CB15) GN=CC_0655 PE=4 SV=1
---------------------------------------------------------------------------ARARARAFGEFIR--------EIPF
DRDLSLIAVS-RDWGAQGIAPGGGEAV-AGGLVAREDAA----ALLACAEEGLFSRYLPVTDESGAQRVWRTEFSACR-DDD-EPYPVMVTARDVTGYAE
SVLRAERDRMALELDDLLVREY--RTRQVFFAPDLQKYCTFK------DDPLEIVHPEDRQRCA-DLVASRKLGEARVFEFKLKRDDGIETWVRSVGKVF
IGQDGQPEKLVNLFKDITDRRRQTEAIETLAFKDPLTGLPNRTLFQHRFQEAVSASETLGEMFGLIMIDVDHFKDINDTLGHDAGDALLKRLAGMLQHAF
RTGDTVARLGGDEFAVILRGLHGADMTRPIEALQDLLRRPIQHGGRSFTASASIGAALHGDLDADPAHMIKNADIALYRAKEAGRNRSIVFEPSMRSEVE
RRLELLRDVRAALTENEFTLYYQPVVDIRENRVAGFEALMRWVHPEQGVLTPARFMAAFEDQDLSLKLGDVAFETALKQMRAWLDEGVE--RVAVNISSA
QFRSGRLAEEIQERLARWSVPCERLTIEVTENVYMGWGDLVSETVRRLHEAGVMIALDDFGTGYASLANLRQFPIDRLKIDKSFVQ----NGEDEAIVKA
VITLGTSMGMKVVAEGVEDAEQLEALARYGCDQIQGYHFGRPMPAGEVAGFLKGFG----
>tr|J2Q3G9|J2Q3G9_9CAUL PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Caulobacter sp. AP07 GN=PMI01_01390 PE=4 SV=1
---------------------------------------------------------------------------PHLMMDAFETFVR--------HAPF
DSAFRLTAVS-PDWAAHGVIPDGDDF--RRALVNPEDID----RLERCVAFGEFSRYRSVSVAGAAPRIWRTEFAATRAGELGRTLAVIVTARDVSGFAE
TALKAERDQMALELDDLMVREY--RTGEIYCSPELEKWCMFK------DDPLEIVHPDDRERMA-ELVRNRKDGEAQVFEFRLNRDDGVETWVRSVGKKF
LGADGKPERLVNLFKDITDRRRQTEAVENLAFRDPLTGLPNRAYFQRKFQEAVDASELMGELFGLIMIDVDHFKDINDTLGHDAGDALLKRLSEMLHAAF
RAGDTVARLGGDEFAVILRGLHSADMMRPVSALQELLRRPIEHGGRSFSVSASIGAALHGDLDADPSHMIKNADIALYRAKDEGRNRSVVFDPSMRSALE
QRIELLRDVRAAITAKEFVLYYQPVVDIDSHTVVGFEALMRWDHPEQGVLTPDRFMAAFEDQDLSLKLGDLAFESALKQMRDWMDAGVE--RVAVNISAA
QFRSGQLAEEVQARLARWNVPCDRLTIEVTENVYMGWGEMVSDTVRQLHTAGVMIALDDFGTGYASLANLRQFPIDRLKIDKSFVQ----NVEDAAIVKA
VITLGSSMGMKVVAEGVEDQSQLDALAGYGCDQIQGYHFSRPMPAGMVPEYLRGFG----
>tr|B0SXM6|B0SXM6_CAUSK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Caulobacter sp. (strain K31) GN=Caul_4114 PE=4 SV=1
---------------------------------------------------------------------------LSALMDAFETFVR--------HAPF
DNAFRLTAVS-PDWADHTLTPGGDDF--RRALASPEDVE----SLERCVAFGEFSRYRSVETEGTQPRIWRTEFAAAL-TETGRALAVIVTARDVTGYAE
TALKAECDQMALELDDLIVREY--RTGEIHFAPDLERWCQFK------DDPLEVVHPDDREKMA-ELVRARKDGEAQVFEFRLNRDDGVETWVRSVGKRF
LGADGKPERLVNLFKDITDRRRQTEAVENLAFKDPLTGLPNRAYFNRKFQEAVDASEIMGELFGLIMIDVDHFKDINDTLGHDAGDALLKRLAEMLHAAF
RSGDTVARLGGDEFAVILRGLHSADMMRPVNALQDLLRRPIEHGGRSFSVSASIGAALHGDLDADPSHMIKNADIALYRAKDEGRNRSVVFTPAMRSSLE
QRIELLRDVRAAITAREFVLYYQPVVDIASNSVSGFEALMRWDHPEQGVLTPDRFMCAFEDQDLSLKLGDLALEGALKQMRDWIDQGVE--RVAVNISAA
QFRSGRLAEEVQDRLARWGVPCDRLTIEVTENVYMGWGEMVSDTVRALHKAGVMIALDDFGTGYASLANLRQFPIDRLKIDKSFVQ----NTEDAAIVKA
VITLGSSMGMKVVAEGVEDQAQLDALAGYGCDQIQGYHFSRPMPAARVPGYLNGFG----
>tr|A0A0A0BW92|A0A0A0BW92_9CELL Diguanylate phosphodiesterase OS=Cellulomonas carbonis T26 GN=N868_08855 PE=4 SV=1
---------------------------------------------------------------------------DRGAVGAFVVVHANAV--AA-----
----------------------RGLTE-GTLWVAPDG--GVGARYVDAVEHGRFVLDAVPVAG-TRARRYA--DLRVVPLADDELL---VSARDVTAHRA
ADREREHSESAFDGAPVGMVIVSLEGTVLEVNQALADIVDADPADLVGRSCYDFLHPDEVAPVRLADMAAG-RRKGYQHEKRLLRADGSWAWVRATASAV
AR-DGVPAYVIEHVEDITARRRAEAELARRALYDPLTGLANRVLLMDRLGSAVEAAERDGAVLAVLFLDLDRFKDVNDTLGHTAGDDVIRELAGRLARLA
PLPSTVARLAGDEFVLALR-VADAEATRVAERVVQDLARPVMVRGFRLVVQGSVGVTTTR-GGTEPEDLLREADLAMHHAKGGGPRRWALYDEPMHRLAL
ERLDVEESLRRALAHDGFRLLFQPIVDTTDGRIVSAEALLRLEHPTRGLLGPESFIGVAEGSDLIVPIGRWVLEEACRWLARWVEVA-PDMQVTVNVSTR
QVSHLALADQVADATRVSGADPSHLLLEITEHVLLDAGDDAARELARVTDAGPRLAIDDFGTGYASLSYLKRFPVSVVKIDRSFVNGLDRPGEDTAIVEA
VIGLARTLGLGVVGEGVETAGQLAALQRLGCGRAQGFHIGRPMTGAELGTLLMRVP----
>tr|A0A021VVC2|A0A021VVC2_9CELL Uncharacterized protein OS=Actinotalea ferrariae CF5-4 GN=N866_13210 PE=4 SV=1
---------------------------------------------------------------------------ATGTVTRFVVVHANTP--AV-----
----------------------RGTDV-GDEWVPPDDDAGPAARYVQVLTGGTLLLESLFVPTPDGEERYV--DLRVVRLG-DELL---VTWRDVTAQLI
VDRELDHSESAFDGAPVGMLILSLEGRILEANQTLADLVGRAPEDLMGRPSAELHHPDDLAAAFEARMAAG-SSSGYQQERRLRRGDGGWAWVRVTASVV
HR-EGSPSYVIEHVEDVTARRAAEAELAHRALYDSLTGLGNRTLLMDHLRQAVGQLGTD-RALAVLCCDLDRFRDVNDTLGHTAGDEVLREMAHRLSETV
RPPDTVARLSGDEFVVAMR-VRDTDGLRVARRLHERMSEPVDVRGFRLVVGPSIGVTTTTDPQADPEILLREADLAMHQAKRAGRDRWVLYDETLHTMAV
ERLATEEALRHALDHGGFRLLFQPIVDVADGRVVSAEALLRLEHPERGTLAPEAFIDVAEASDLIVPIGDWVLQEACRQLARWQARV-PDMQVTVNVSTR
QVSHLALADQLDRAARDSGADPGRVLLEITEHVLLDAGDAAAAELARVTDAGSRLAIDDFGTGYASLAYLKRFPVSVVKIDRTFVEGLDRPGEDTAIVEA
VIGLARTLGLQVVAEGVETAGQLAALRRLGCTRVQGFHLGRPMTGEELADVLDRSR----
>tr|H6RJ52|H6RJ52_BLASD Uncharacterized protein OS=Blastococcus saxobsidens (strain DD2) GN=BLASA_3969 PE=4 SV=1
---------------------------------------------------------------------------RLTSRVFWDLAVWMIGLGIAVGLVF
GLGVPAEYAERPLFQAACLGAGGALSY-ALCRCLVGGRLAVLSSHLRSVAQG-SQA-------SRTGDWAQSTSQRIRVDSDDQ-----------AQAFN
SLLDALEAGSLVRNASDVITVV--AGTVTYQTPSVGWVLGYPPGTLIGTDIHALVHPEDARTFRDSVVRIRHRNGSWR---WTETVVN-----------D
LLDDPAVTGVVLTTRDVSDRRELEEQLRTQAFYDPLTGLPNRALFMDRLRAAEELERDTGTPAAVLFLDLDNLKTVNDTLGHDGGDALLEVVAQRVGACL
RPGDTLARLAGDEFAVLLGGPQSEMALRVAERILGALREPVLVVDRMVRAGLSIGLATTATAGVSGIGLLRAADIAMYVAKTSGKGRCEAFQPSHHADHL
ERERLQAGLYQALERHELVLHYQPIVDLASREINGYEALVRWQHPERGLVPPAQFITLAEDSGLIVPIGRWILREATRQAAAWQRIDGRAPRMSVNVSVC
QFRHPDLVDDVTEALRASGLAPDRLTLEITESLFAQDTTGTTLKLEQLKALGVRLALDDFGTGYSSLSYLRRFPIDILKIDKSFVDGVATSCEDRAVIGA
IVALGQTLHLDLVAEGIETAEELAALEALGVQSGQGYHLGRPAPPQYASPGAERR-----
>tr|M2ZT01|M2ZT01_9PROT Signal transduction protein OS=Magnetospirillum sp. SO-1 GN=H261_08368 PE=4 SV=1
---------------------------------------------------------------------------GGDDLGGYRSLFENAVEGIYRTTPD
GRYLDANPALARIYGYNDPAELLTDIA-RGLYVDPADR----ERFRGILARDSVRNFEARVRTRSGQVIWIAENARAVYDPRGKLVCYEGTVQDVTARKQ
AEESLRLAATVFETVGEAIVVT--ERRILAVNAAFERMTGWSAAEVTGRPCDLLA-VE-MIGLREEMWRLAANTGQWSGETWTRRKDSEPFPAALALTAV
DQGQDGDGRFVLLLRDITRKRRDEQRIRFHASHDALTRLPNRHTVMEALGEAIVRAEQTGERLAVLYLDVNRFKDINDSYGHAVGDELLRQVARRLKACV
RASDIIGRLGGDEFVMLLPSVGDSAAQACAGKVLYAFAEPFDMDGLQLFAGTSIGIALYPDDADGAESLLSRADAAMYHAKRGGL-PYSCFDMEMDRQVA
ERVSLENDLRLALGEDQFRLVFQPKVDALSGTIVGAEALIRWRHPVRADVSPGLFIPVAERAGLIGAIDDWVLGEACRQVAKWRRQGLI--AISVNLSPA
QFHDGRLKDKVKAALAESGLPPAVLELEITETMMASDVDRAIEILGQLTTLGVRVSLDDFGTGYSSLAYLKLFPVSTLKIDRAFVTELPGNAKDGAIIAS
IIALAGNLGFTVIAEGVETREQAAFLAARGCPVMQGFLFSRPVDADTFAGLLATPE----
>tr|V6F084|V6F084_9PROT DosP protein OS=Magnetospirillum gryphiswaldense MSR-1 v2 GN=dosP PE=4 SV=1
---------------------------------------------------------------------------AKAISNQYRSLFENAVEGIYRTTPS
GRYLNANQALARIYGYDSPKALLTDIA-HGLYVHPEDR----DRFKRLLDHESVRNFEAQVYRKTGEIIWIAENARLVRDDDGNAVCYEGTVQDITERKL
TEERLRLAATVYENVGEAIIVT--DDVVHAINPAFSRMTGFAVDQVVGLKSKFIA-DE-INDPKTEAWDFARRGETWHGELWGRRSNGDVFPASVALTGV
QGENGEVGSFVMVASDVTRRKMDEQRIRFHARHDALTKLANRHTVMEALGDAIVRAENEGNRLALLFLDVNHFKDVNDSFGHAAGDELLKQVARRLKGCV
RASDIIGRLGGDEFVVALPSITDQGALACVEKVLYAFSEPFSLPEQELYASTSIGVALYPDHADCAETLLSHADAAMYHAKAGGN-AYRFYDSDMDRQAA
ERVNLENDLRHALAEGQFRLNYQPKIDGISRKVVAAEALIRWKHPTRGNVSPALFIPVAERAGLIGAIGDWALAEACRQMRLWLDDGIE--CISVNLSPA
QFHDASLKQKVERSLSQWGLSPSLLELEITETMMATEVDRAIAIVGELGQMGVRMSIDDFGTGYSSLAYLKLFPVNVLKIDRAFIKELPGNRKDGAIVSS
IATLAANLGFEVIAEGVETQAQAGFLLTKGVTLMQGFLFSPAVPPDEFAQLVRTGV----
>tr|K9HRJ5|K9HRJ5_9PROT Diguanylate cyclase OS=Caenispirillum salinarum AK4 GN=C882_0001 PE=4 SV=1
---------------------------------------------------------------------------LREAERRYRGIFENAVEGIYQSTAR
GDYVDVNPALARIYGYGDAETLLTDIA-GQLYVDPAAR----QRFKDLMERHGVTEFEALIRRKDGRVIWITENARCVRDEAGRLLYYEGTVEDITARKH
AEAEIRMLAKVFESVAEGILLV--DLMVREVNPAYARITGTAAEDLIGRPAHLLA-PG-FHEKATDIWTTARDTGHWRGEVWSERAGDRPFLSDLSVTTV
RDETGAVLRFVAAVTDITRRKEDEERIRFQANYDTLTRLPNRHLITDRLEQAILRAERCGGRVGVLFLDLDRFKYINDSYGHAAGDELLKLAARRLRHCV
RMSDGVGRLGGDEFMIVLPECGPNTGAYIAEKVLYSLSEPFAIAGTELFSVPSIGISYWPDHGETAHDLIRRADLAMYHAKRGDERRYATYLPSMEEQSL
AVLNMENDLRLALAAGAFELHFQPKVSAETGDVMGAEALIRWPHPERGMISPMDFIPLAEESGLIMPLGRWILRDACRRMVAWRAQGIA--SLSVNVSPR
QFADPSLTETIERTLEETGLPPECLDIEITESVTSGDVERVISTMAALKAMGITLSVDDFGTGYSSLNYLKRFPIDTLKIDQSFVRDLMDKGKDAAICAT
VVALGNNLGFTVVAEGVETADQARFLYEKGCHMLQGYWISRPLPAAAFTAWLAEMS----
>tr|K9S788|K9S788_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Geitlerinema sp. PCC 7407 GN=GEI7407_1132 PE=4 SV=1
---------------------------------------------------------------------------LRQTESKYRSIFENAVEGIFQTTPE
GRFLSANPALARLYGYDSPEALLTDIE-TQLYVDPHRR----QEFIDRMATEDVTEFESAVYQRDGSIIWITENARTVRDADGAILYYEGFVEDVTQHKR
AEDALRESEVIFEKAAIGLSLT--QGRLMAANPAMQAMLGYSNLELQQCSFDHYTYPEDLYPDLTEELKLG-QRDQYDIEKRYVRKDGRILWARLTVSLV
CNAEGTPLFSICMMQDITEQRQSEAKLLRAALHDTLTGLPNRTFLMERLQEAVTLTQDSQAQFAVLFLDLDRFKIVNDSIGHLAGDRLLVEIAQRISACV
RAEDTVARLGGDEFAILLTDIGSQDAIDVADRIQQTLKTPFNLGSQEVFSSVSIGIASSMSGYEQPEHLLRDADNAMYRAKAQGKARCVVFDTHMHDRAL
QLLRLENDLRRAVERQEFLVYYQPIVSLDMGRIAGFEALVRWRHPERGMVSPADFVPIAEETGLILPLGYWVLRESCRQIRAWQEAFPQPLFISVNLSGR
QFTQPGLVECIEQVLSETGLEGGSLRLEITESVLIENADMVTKLLERLRSQRIHLCIDDFGTGYSSLSYLHRFPVNVLKIDRSFINKMGAEDENSEIVRT
IVSLAHNLGVDVTAEGVETEAQLVKLWALQCEYAQGHFFSAALSSEAAEALLAAAP----
>tr|Q21SH7|Q21SH7_RHOFT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T11
---------------------------------------------------------------------------MTENLINFQLILTTISDGIVVVDQR
GVVLYANESAERLFE----RGEGKDLA-VPIH--SGETRQ-----------------DINLIRPSGIGWAELRSAPITWDK--QIC-----VRDITERKT
SDLGLHLAD---DSTREGLMVT--AQRIVRINPAFSEITGYSAADVLDQTPALLRSGRHDSAFYAAMWDSINVSGHWQGEVWNRRKNSEIYPQLISIDVI
RDHTGRVCNYVAVLTDLSKLRSSQLELDFLAHHDPLTRLPNRLLLLSRLQHGIELAQRDGTHLALLMLDLDRFKDINDSFGHLVGDELLQLVATRLVKQV
RTIDTVGRFGGDEFSVLMEDVAGEQAARVANDIIRVLSEPYGLSSGEVRIGASVGISIYPDNGLTPELMLQQADSALYQAKIEGRGRFAYFSESLTQAAR
ARIDIEVRLRRAITQGELRVYYQPQVDIPSGRIVGAEALVRWQCPIEGLVPPARFITIAEATGLIGEIDDWVLRETCQQGQRWRAA-GLTLTLAVNLSAY
QFLQGDISQTVAQVLRDTGYPAAFLELELTESALMQREAQAIQMLDRLKALGVRLAIDDFGTGYSSLAYLKLFPLDVLKIDKRFIDDIPAHRDDMEIVTA
IIAMAHSLRLKVLAEGVENKEQLAYLQTQGCDQFQGYLTSRPVPAAEFEKLFLSGR----
>tr|A0A080MBB6|A0A080MBB6_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-02 GN=gmr_1 PE=4 SV=1
---------------------------------------------------------------------------LHEQQEFFRLIAESIGEHIAVLDLQ
GRRVYNSPSYRQFFG----NARGTDSF-ADVH--PDDRERVRRVFYETVQTG-GQEIEYRLIRHDGSVRYMASVGKVIQDKDGQIV----VAHDITDRKQ
AEQWERIAA---E-SQQGMFIT--AGVILRVNQAFTEITGYSAEECIGQTPKLLSSGRHDAAFYAAIRHSLERQGSWQGEIWNRRKNAEIFPEWLTISAV
TNNEGRVTHYVSTLADISLRKAAQEEIQQLAFYDALTRLPNRRLLQDRLRTAMAASARSGRQGALLFIDLDNFKTLNDTLGHDMGDCLLQQVAKRLLACV
RDRDTVARLGGDEFVVMLADLDKPQSRIVGEKILAALNRPYDLA-GEYHNTPSVGITLFGSQQDAVDELMKRADLAMYDAKATGRNTYRFFDPQMQAVVT
ARAALERDFREALQRQELFLCYQPQVD-RAGRIVGAEALVRWRHPQRGLVSPAEFIALAEETGLILPLGLWVLETACAQTTVWAAQAGREFTVSVNVSAR
QLRQPNFVEQVLGVLAKTAANPRNLKLELTESMLLDNVQEIIAKMTVLKKHGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDRSFVRDLLSDPNDEAIART
IVALASNLGLEVIAEGVEGVEQRDVLATQGCHTYQGYLFSRPLPLAEFEAFLQAH-----
>tr|G8QJQ2|G8QJQ2_AZOSU PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Azospira oryzae (strain ATCC BAA-33 / DSM 13638 / PS)
---------------------------------------------------------------------------RPGHRQAWPLVLLYLC--AG-----
GALLAVLQG---A-----------------------------------------------------AGLSDGGAAVLVLGSSAALLYRSGTPRELAACRD
YVHRLNLAS---SAAREGIVVT--EGRVEAVNPAFCQITGYGEAELQGFNLRLLKSGRQDGAFYRQLWRDLLESGHWQGEIWNRRKNGETYPQWLTISTV
RDEAHQPVSYVGVFLDLSPIRRSEQKLLHLAHHDPLTDLPNRTLFLARLEHALSLSAREGGSGAVLFLDLDRFKDVNDSLGHPTGDRLLCAVAERLRPCL
RESDTLARLGGDEFLLLLETAATERAAVVAEKLLEQLAAPFRLDDREVYVGASIGICLYPADGDNATTLIQHADSALYQAKAAGRHTFRFYSEAQTRQAD
ARLALEAALRRGLEKEEFLLYYQPQVDLRTASLEGVEALVRWRLPGGELVPPARFIPLAEETGLILPLGEWVLRQACRQMQQWVAR-GLIRRVAVNLSSR
QFRQADLLQRINAILAETGLAPRYLELEITESLLMDNSAQVDAKLEALEAMGIRLAIDDFGTGYSSLSYLKRFPLHTLKLDRSFIRDIADDPVSSNIVAS
IIELGQHLDMDILAEGVETDQQRGILLQNGCRTCQGYLFSHPLPAEELEARWLRAA----
>tr|N6X5U4|N6X5U4_9RHOO PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Thauera sp. 63 GN=C664_19763 PE=4 SV=1
---------------------------------------------------------------------------VVGLRDELATILHALPDPVFELDMD
GRCLSYYARSEDLLTT---SPSGKTVR-EVLA--LDEAESVLQALHEARDTG-SVGRQFKIEGEHGPQWFEMSVAPKPSIADETVL-----SRKITARKQ
AEQVLREREAVVDNIPAEFWAR--EGRCIMENAATVAHWG-----------SLLGSRIDDARVSPADWLAS-NQRAYAGETVRKEFASDIDGVFQCIVAP
IRVGGEIVGICGFNQDITERKRHEEQIHQLAFFDPLTRLPNRRLMLDRLEHALIGSARRHQEGALLLIDLDHFKDLNDTHGHEAGDELLMKVAARLRLCI
RQGDTAARLGGDEFVVVLEDIDGVQANAIAGKIRDELNRPFHLMRGTYHCSASIGITLFGSQDISASELLRRADTAMYQAKAAGRNALCFFDPAMQAAAT
ERAALHADLHRALRDSQFELHYQVQVD-ETRRPIGAEALLRWRHPARGLIFPGSFIGLAEETGLIVPIGTWVLRTACLQLAAWAARPETHLRLAVNVSAR
QFRQAGFTDQLRELIVLTGAPASRLELELTESTLIEDAEAVVERMEELRALGIRFSLDDFGTGYSSLAYLKRLPLSQLKVDQSFVRDVMSDANDATIVET
ILGLGGSLGLSVIAEGVESEDQFAFLAARGCREHQGYLFGRPMGLRDFEALLAVHH----
>tr|A0A0A0C5V9|A0A0A0C5V9_9CELL Uncharacterized protein OS=Actinotalea fermentans ATCC 43279 = JCM 9966 = DSM 3133 GN=N867_08535 PE=4 SV=1
------------------------------------------------------------------------------MASAVQTAAELAAAGLGAEAGA
GR------STTSVVGFGHLAA---PVA-ELVASTPGDDPGVG-----------CHRLGASWNAGTSGRLWVARTGSPFTAADGQMASGLGLALDMIGALE
R----QANQTVLLDIQRAISHR-----LAT---ILAAITDGASTVLHGWPVTLVLDDDGERPLV---AVPVHIHGLAAGELRTTAPDGAAAG-------L
---ERELLQTFAEHASLALTEARTFEAMQEAFWDGLTGLPTRQLLVDRLRHVLRDATA--VGPSLLLLHLDRFGAVNDILGRAAGDELLQQVTERLLSIV
AADATIARFGGAEFAVLLPGPGTP-PEAVARRVIATIERPFTVQGTLVHVGVAVGVAHAVDCSGTADELLSNADVARYRARAAGSGAVVTYDGQMRAALL
ERLEMQAHLQTALDRHELVLHYQPIVELDTGRSTGVEALLRWRHPDRGVVPPSDFIPIAEVTGAIVPIGRWVLQTACRQIARWRLVD-PTLTMNVNVSAH
QLRDPAFPEDVRRALDASGLPGAALILEITESVLLEDDEQTLDSLRALKALGVAVALDDFGTGYSALGYLRRFPVDILKIDRSFVSGGDAHDDGDQLVRT
IVELGRAYALDVVAEGIEDEGQRQRLVELGCSHGQGFHFGRPADEESFDARLATVH----
>tr|H2CLS6|H2CLS6_9LEPT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptonema illini DSM 21528 GN=Lepil_4209 PE=4 SV=1
------------------------------------------------------------------------------DRKVLSVVVADMHGTIL-----
GQAAYLKQGIPSLFSTEPP--------------------SIGELWKRAIADGNQM-----------SLFWAMSGMRHEL----HADSW-AVIETPATSAD
TERLLKESELVVQQTGQMVYDY--RTGTITWAGATSEITGYCAEELAAMNIAEHIHPEDREEALSLLDQARKSRGRYSVDYRFRRKNNSYIHIRDNGAFL
LDEEQIPFRMIGSMADITEQKIAEDIIRHQAHHDGLTGLPNRTLVLDRIDLALAHARRVGEGFAVLFLDLDRFKPINDTLGHAVGDGLLIAVAQRLVGAL
RPDDTVSRNGGDEFIVLLPGVPDPAAGIVAEKIIHELGKPFFIDGFELHISASIGIAVFPTDGKNAEEIIRNADVALYRSKEAGRDRYAFYSDTRGSFGR
ERITLQQELKAAIPDDQLRLVFLPTISLTSSAVSSYEALLRWQHPRLGLLLPEAFLPIAEETGLMLAIGDWVIDEGLANLKRWSLRGD-PSLLRLNISAQ
QFFQPQFVRRLADRVIAFDLPAQKVRLEIHEAIALQRGGHTEQILRELDAMGFSLSIDNFGTGYGALRSLQDYPIREVKIDRSLIRDMGE-RRSQWLIQG
MVQMARALGLSTVAGGVEHEGQKTLLRQYGCDEAQGWLFGTALQPIGRNPAQ--------
>tr|C6WJ06|C6WJ06_ACTMD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064
--------------------------------------------------------------VTE---ARAMERQLREDRRRLADAQRAARLGVWEWDLA
TGEVVWSDMLAELFGVPRDERTTYR-TYL-DLVHPDDRGWVDDMWQQLATEETPVQCEHRIVRRDGAVRVFRSHGVVINGPDGR-TLAVGTAQDITEQRV
AETRMQRSSDLVSLTPVGIGLFDEGERLVEANDALCDLLGMDLEQLRGMTAEQLTDPADNDDRLQSVSRMTEFGRAHPQRILVR-PDGERVYCELHIALS
VQDDG-RRFWLIVFQDITERRRTAEALRHQATHDDLTGLPNRALVKELLGELLEG--GDRAKVAVLFCDIDNFKRVNDSLGHDAGDELLVALARRLEGGL
PDGCTAARLSGDEYVIICENIDAGGVDALATRVAGLLRTAVPVHGQLVRVSASIGAAVPNGSRATGADLLRFADAAMFEAKRSGAGRVSLASAALIASAD
RQVHLEGQLRDALAHDGLALHYQPVVGV-DGSVQTAEALVRWPHPDRGLLSPDIFLPVAEQGDLLRELDRWVLRTALKEAATWPAPDGKPVAVAVNLAGL
VPGDPEFVDIVSATIAESGIPWDRVVLELVETALVDLPSRVRQSMAELVERGVQFAVDDFGTGYSSLARLKDLPAQIIKVDRRFVAGVGSDSSDFAVARA
VVDMARAMGRKCVAEGVETATQFHVLRGVGVDAYQGWLFSRPVPPKEFRAVLALGPL---
>tr|K0KDA6|K0KDA6_SACES Saccharothrix espanaensis DSM 44229 complete genome OS=Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NB
--------------------------------------------------------------VTE---ARALELQLRDDRRRLADAQRAAQLGVWEWDFT
TGDVVWSDMLADLFGVPRDERTRYQ-TYL-DLVHPEDRGWVDELWQQLATDEVPVQFEHRIVRRDGKLRVFRSHGVVVRGPDGR-PLAVGTAQDVTEQRA
AETRMKRSSDLVSLTPVGIGLFDEAERLVDANDALCDLLGIDLEQLRGMTAEQLTHPEDKENRLHSVSRMTQNGRVHPQRILVR-PDGERVYCELHIALS
VQDDG-RRFWLTVFQDITERRRASEALRHQATHDELTGLPNRALVKELLATLLAA--ENRSRVAVLFCDIDNFKRVNDSLGHDAGDELLVALARRLEGGL
PEGCTAARLSGDEYVIICENIDLGGVDALATKVAGLLRTAVPVHGQLVRVSASIGAAVPNGSRATGNDLLRFADAAMFEAKRAGAGRVSLASAALIASAD
RQVHLEGQLRDALANDGLALHFQPVVGV-DGAVQTAEALVRWPHPDRGLLPPDIFLPVAEQGDLLRELDRWVLRTALKEASTWPEPNGKPVSVAVNLAGL
VPGDPEFVDIVANTIAEAGIPWDRVVLELVETALVDLPSRVRQSMDELVARGIRFAVDDFGTGYSSLARLKDLPAQIIKVDRRFVSGVGNDSSDFAVARA
VVDMARAMGRKCVAEGVETATQFHVLRGVGVDAYQGWLFSRPVPPREFRAVLALGPL---
>tr|W5WST8|W5WST8_9PSEU Uncharacterized protein OS=Kutzneria albida DSM 43870 GN=KALB_7852 PE=4 SV=1
--------------------------------------------------------------VTG---QRALERDLREERRRLSDAQRVANLGTWEWDTS
TDECLWSDMMRGLLGVTDQERATYQ-RYL-ALVHPDDRSWVDELWHQLATTREPVECEHRIVRPDGAVRVLRCHGGTIAGPEDSPTRLVGTAQDITDQRA
AETRMRLSSDLVAVTPVGIGLFDESERLVDANDALCDLLGIDLEQLRGMTAGALTHPDEPAGWLPAAGKLIGADRSYPQRVLVR-PDGELVYCELHIAIS
VQDDG-RRFWLVVFQDITERRRVAEALRHQAHHDELTGLPNRTAVKEMLAKLLQG--EAAERIAVLFCDIDNFKRVNDSLGHDAGDELLVALARRLEGGL
PEGSTAARLSGDEYVIICEDIEAGGVDALATRVASLLRAAVPVHGQLVRVSASIGAAVPNGSRATGVDLLRFADAAMFEAKRRGAGRVSLASAALIASAD
RQVHLEGQLREALAKDGLTLHFQPVVGV-DGTVLTAEALVRWPHPDRGLLAPDVFLPVAEQGDLLRELDRWVLRTALREASTWPAPNGQPVAVAVNLSGL
VPGDPDFVDAVSNAVAESGIDWDRVVLELVETALVDLPSRTRQAMGVLVERGVRFAVDDFGTGYSSLARLKDLPAQIIKVDRRFVSGVGNDPSDFAVARA
VVDMARAMGRSCVAEGVETATQFHVLHGVGVDAYQGWLFSRPVPPREFRAVLALGPL---
>tr|W7SLJ1|W7SLJ1_9PSEU Diguanylate cyclaSe/phosphodiesterase OS=Kutzneria sp. 744 GN=KUTG_06224 PE=4 SV=1
--------------------------------------------------------------VTE---QRALERELRDERRRLSDAQRVASLGTWEWNTG
TDDCNWSGMMRELLGVDEQERATYQ-RYM-SLVHPDDRGWVDELWQQLAVNREPVECEHRIVRPDGLVRVLRCHGASVQGVG---PVLVGTAQDVTAQRT
AEARMKLSSDLVAVTPVGIGLFDEAERLVDANDALCDLLGIELEQLRGMTASSITHPDEPVGWLSAAARLT-SEGGFPQRILLR-PDGELVYCELHIAIS
VQDDG-RRFWLVVFQDITERRRVAESLRHQAHHDELTGLPNRAAVKETLTRLLAG--EGAEKIAVLFCDIDNFKRVNDSLGHDAGDELLVALARRLEGGL
PSGCTAARMSGDEYVIICDDIDAGGVEALGTRVASLLRAAVPVHGQLVRVSASIGAAIPNGSRTSGADLLRFADAAMFEAKRRGAGRVSLASAALIASAD
RQVHLEGQLREALAKDGLTLHFQPVVGV-DGTVQTAEALVRWPHPDRGLLAPDAFLPVAEQADMMRELDRWVLRTALREASTWPVPNGKPVAVAVNLSGL
VPGDPDFVDAVSNAVAESGIAWDRVVLELVETALVDLPCKTMQQMDILVAKGVRFAVDDFGTGYSSLARLKDLPAQIIKVDRRFVSGVGNDPSDFAVARA
VVDMARAMGRSCVAEGVETATQFHVLHGVGVDAYQGWLFSRPVPPREFRAVLALGPL---
>tr|F7XEA4|F7XEA4_SINMM Diguanylate cyclase/phosphodiesterase OS=Sinorhizobium meliloti (strain SM11) GN=SM11_pC0806 PE=4 SV=1
--------------------------------------------------------------ITE---RRAAEIAQQEAQAFIRSIFDSSPDCVRVLDME
GRPLLMNEAGRRIFGLNEGAPVTGQ-TWD-SIGRASDADKVEAAWESV-RRGKTARFEISVRDAGGEERCMDVISAPITDHHGKPFRILSIWRDITDAKR
ASDEISRAQAVLESTMDSVMLLDADWRVRYLNE---------------NARKLLQVGDEA--LGRVFWKLFPEEGSFCREVMDRRVRSSSLGRWVEANAS
PTRDGICRDITERRRAEEDTLLAQKQMAHMARHDMLTGLANRMFFRECFEEALNES-N-HARMAVLCLDLDGFKAVNDTLGHPAGDALLRQVSTRLIQAV
RSTETVARLGGDEFAIIQPLMESDEAFRLAQRLIDTLSEPFSIEGAAATVGTSIGIAFAPEDGTSADELIKAADIALYSAKSSGRGTYKLFDVAMHAQLQ
THQQMKITMRDALARGEFELHYQPLVSLESRCVSCCEALLRWRHPDRGMIAPSEFIPIAEETGLIVPIGEWILGEACRQAARWPE----RVSVAVNLSPV
QFKHRNLVRAVAKALSATRLDPARLQLEITETVLLDESEHNLELLQDLRRLGVKIAMDDFGTGYSSLGYLRSFPFDKIKVDQAFVRDLPHGKESLAIVKA
VAGLGQSLGMTTSVEGVETEDQLAVVDSEGFNEVQGYLFSRPLPAAEISKLIAAGSL---
>tr|C3KQA4|C3KQA4_RHISN Uncharacterized protein OS=Rhizobium sp. (strain NGR234) GN=NGR_b08060 PE=4 SV=1
--------------------------------------------------------------ITE---RRQAELALVESEALIRSVFESTPDCIRLLDLD
GRPLLMNRAGRQLFGLGESTRLEDV-RWE-KMVPASDVAKAEAVYSEV-RQGRTTRVETAIRDNTGAERYMDVITAPVLGAFGEPIRMLAIWRDITEARK
ARDDAEAARRVLESTMDSVVVADRDWRIEYLNS---------------KAMRLLQVDEQA--VGLDLWRLFPVNSVFYRKVMSEHSSTEGLERWLEVHAA
PTFEGIFRDITERHKAEQERLLAHRQIHHMARHDAVTGLPNRQFLREAFERLFEGT-RARSKTAVLSLDLDGFKAVNDAYGHPTGDLLLRSVAERLRRCV
EGGDTVARLGGDEFVILRTGVRQEEAIDLSQRIIDALGAPYELDGVQADIGVRVGIAFSPRDGRAADQLIKAADIALYRAKARGRGTYIQFEPGMDAHLQ
ARQQMKVELRRALANDELELHYQPLVNLRTGLIATCEALVRWNHPEKGAISPVDFIPLAEETGLIVPLGEWILRRACAEAVQWPQ----QVSVAVNLSPL
QFRSRRLVSVVRDTLKESGLDASRLQIEVTESVLLDESDNNLRVLQDIRRLGVKIAMDDFGTGYSSLGYLRTFAFDKIKVDRGFISDLPTGKESLAIIRA
VAGIGRTLGITTAVEGVETQTQLDVIHAEGFDEAQGYLFARPLTAARVLEAIQVSLL---
>tr|I3X6S6|I3X6S6_RHIFR Uncharacterized protein y4lL OS=Sinorhizobium fredii USDA 257 GN=USDA257_c30120 PE=4 SV=1
--------------------------------------------------------------ITE---RRAAELAQQESQAFIRSIFDSSPDCVRVLDLE
GRPLLMNKAGRRIFGLAEGAPLTKT-TWD-IVGKDADAQKVLEGWAKV-RAGETARFEITVRDANDEERCMDVIAAPIIGREGKPVRMLSIWRDITAAKR
ASEEISRAQAVLESTMDSVMLLDPRWRIRYLNE---------------NAKRLLRIGDES--LGKVFWKLFPKEGNFCQEVMNRRVRSPSLDRWIEANAS
PTQEGICRDITEHRQAEEDKLLAQKQMAHLARHDMLTGLANRMFFRECFDRALSEK-GAAGRMAVLCLDLDGFKAINDTLGHPAGDAVLRQVSARLVQSV
RPADVVARLGGDEFAIIHPLATTDDAVRLARRVIDTLCEPFTIEGVSATVGASVGIAFAPDDGTSADELIKAADIALYNAKASGRGTYKRFDLAMHAQLQ
AHQQVKIALRGALQRNEFELHYQPLISLRSRRVTGCEALLRWRNPERGMVAPSEFIPIAEETGLIVPIGEWILDQACRQAAQWPE----RVSIAINLSPV
QFKHRNLVKTVADALSASRLTPARLQLEITESVLLDESEHNIQLLQELRGLGVKIAMDDFGTGYSSLGYLRSFPFDKIKVDQAFVRDLPHGKESLAIVKA
VAGLGHSLGMTTTIEGIETEAQLAAVNAEGFHEVQGYIFSRPVPPSEISKLIDGPLE---
>tr|A0A0B0H1W2|A0A0B0H1W2_SOVGS PAS S-box/diguanylate cyclase domain-containing protein OS=Solemya velum gill symbiont GN=JV46_24230 PE=4 SV=1
--------------------------------------------------------------ITK---RKQAENELRLSKAQLSEAQRIAKTGSWTLDLS
NNHLDWSDEVYRLFEIDKTQ--FNS-SYEADAVHPDD---VNQAYLDSLNSHKPYEMTHRILVGDGHIKYVHETCETLFDKDGKALLSRGTVQDITERKQ
AEDQMRIAAS-----QQGIMVTDADGIILQVNSAFMEMSGYTADEIIGNTPKMFQSGRHGPAFYEEMWQTINSDGFWQGEIWDRRKNGEVYPKLLSISAV
TDTDGKISHYVGSHADITEKKSAEKKIDKLAYYDQLTGLPNKVQFMNRLEQTLEACVRDNQYSAILMIDLDHFQKLNDTLGHVIGDQLLVQVASLLEEST
SSVDTVARFGGDKFVVILPELASKTAEKVTRNILHTLNKEYQLGRSSHHSTVSIGVNLFGSETLTIDVLLKQAELAMYESKSAGRNTMTCYDPKMQSSVS
KLVTMEKELRSALENEEFFLDYQPQASLQNGRIISVEALIRWNSPKLGLVSPDEFIPVLEEMELIVDVGNWVLGESCECLKRWHQSGFDYIRIGINVSPA
QFKNKNFLDTVRDILKKTKVPPGYVELEITEGVVMDDPQYAESLLNDLHKLGLKIAIDDFGTGYSSLSNLMHLPFDTLKIDRAFVKELPGNADSVSFCNA
ILHWPRL-----------------------------------------------------
>tr|D9SCE6|D9SCE6_GALCS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Gallionella capsiferriformans (strain ES-2) GN=Galf_2528 PE=4 S
--------------------------------------------------------------ITQ---RKVDEELVLKNLEKWKKLFDILPIGVSIVNSK
NGIVDFNPSL---------EAILGI-SKEG----QGDYDNTDNTHMDA--DEFPSL---RAIKEQGDIIWTSVSAAPLS---YDSNSCVTVTTDITKRKQ
FESELRVSAT-----QEGILITDENNVMLRTNAAFTAITGYTNKEAIGQNPRLLSSGRQNASFYSAMWKAINTTGVWEGEIWNRRKNGEIYPEHLTVTAV
KDRNGMVTNYVGVLSDLTQRKAAEEKIENLAFFDPLTKLPNRRLLLDRLKQAMASATRSVTNGAVLFIDLDNFKALNDTYGHPMGDLLLQQVAKRLVSSV
RDGDTVSRFGGDEFVVLLEGFDEPQAETVGEQIFAALRQPYLIGTHEYHGTSSIGATLFNDKQQSIDELMKQADIAMYQAKKEGRNVLRFFDPQMQETIA
KRTALEGDLRKAIENHQFQLHYQIQVDE-SRHPFGAEALIRWFHPEHGMVSPDQFIPLAEESDLILPIGYWVLETACARIQRWQHDAKSGFVLSVNVSAK
QFRQTDFVNQVQSLIQQYEINPSLLKLELTESMLLDNIEDTIATMSALKELGVKFSLDDFGTGYSSLQYLKRLPLDQLKIDQSFVRDIAVDASDRAIVRT
IIAMAHSLDLDVIAEGVETEEQQKHLSSKGCKNFQGYLFGKPVPIEQFETSLRKSLF---
>tr|G3J0G5|G3J0G5_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_3836 PE=4 SV=1
--------------------------------------------------------------ITE---RKQAERVLNQ----IKAMIDISLDGFWVADLM
GNVLQAN--E-------AYAKIIGY-SIDESQLE---AKEI-KAHIVKIVTQGYDLFETRHLHKDGHTIDIEVSAAFLS--E--FQQFCVFCRDITERKR
IEMDLRIAAS-----QEAMVITDTTSVILRINKAFTESTGYTEEEAVGQKISILKSGRHGAAFYAAMWKGILSVGAWQGEIWDRRKNGEIYPKWLSITAV
KGSDGVVSHYVGTHTDITERKAAEEQIKLLAFYDPLTRLPNRRLLQERLKHGINVERRDGKQLGLLMLDLDRFKAINDSLGHLAGDDLLQQVAERIKARL
RDVDMVARLGGDEFIVLLEDIAQEDAARVAKEIIADLTKPFCLTHSNVQIGVSIGISLYPQHGDTSELLMDHADAALYQAKDAGRGCFAYFSEDLTIAAR
ERIALETRLRHAIEQQELRVFFQPQVDIASGRIVGAEALVRWQDPVEGLIPPIRFIPIAEETGLIVEVGEWVLRETCRQGRQWLDAGLPPLTLAVNVSSH
QFRRSDICALVATVLSDTGFPSQQLELEITESGLMENQDNATAILNSLRAQGVRLAIDDFGTGYSSLAYLKHFPLDVLKIDKRFIDDIPFQQDDMEIAAT
IVAMGHILGFKVLAEGVETMAQLAFLQEKGCDMYQGYIKSKPVPAHEFAELLRAQQY---
>tr|D9SJE9|D9SJE9_GALCS Diguanylate cyclase/phosphodiesterase with PAS/PAC and MHYT sensor(S) OS=Gallionella capsiferriformans (strain ES-2) GN=Galf_23
----------------------------------------------------------------------LGAVVVKRDITKFASL---IKQSHALISDT
NGVIVLSYDQAYLFQAMPEAAVLTM-SVEQAVIEPLQMKSFAAAVLVG---NKPQVLVSKALPDDNEKNWLFLLLAATG--SMLIIAVSVVVIYLRDSLR
AAADLRVSAA-----QEGMFVTDAEGVIQRVNNAFTQLTGYSASEVIGQTPRLLSSGQHDAVFYALMWQSINETGKWAGEIWNRRKNGEIYPEYLAITAV
KDESGVVNNYVATFNDISDSKAATNEIQLLAFYDALTGLPNRRLLLDRLLQALASSVRSNRMGALLLIDLDNFKTLNETMGHDIGDLLLRQVAERLTACV
RNGDTVARLGGDEFIVMLEEIGATHTTTIAEKILNSLNLPYRLEKHECHSTPSIGATLFSGTQQSADELMKQVDIAMYQAKQAGRNGLRFFDSKMQDAIS
ARASLEADLRVALINSEFQLHYQIQVNS-LGAALGAEVLIRWMHPQRGMVSPAQFIPLAEESGLILPVGEWVLKTACHQLKVWQDNALRELTLAVNVSSK
QFRQAEFVELVKKTLQSSGANPSLLKLELTESLLLENIDEIIAKMNELKLMGIHFSIDDFGTGYSSLQYIKRLPLDQLKIDQSFVRDIMDDNNDAAIVQT
IIAMSDALGLNVIAEGVETREQRAFLDSHGCHTFQGYLFSKPIPLEQFEILLATKHA---
>tr|E7RWK4|E7RWK4_9BURK Diguanylate cyclase (GGDEF) domain protein OS=Lautropia mirabilis ATCC 51599 GN=HMPREF0551_1066 PE=4 SV=1
-----------------------------------------------------------------------------------------TKGRLLTLSLS
GRPIIDEKTGQLLYYRGVGRDVTRE-NHQNDILQELDAQG---------------------QDES------TLVCRTLNWAGGLHMR------PVPESSR
VTIEEKCGTELLANSPEAMVLRE------------------------------------------------------GALLWLHRKDGARYQMVLLFFTP
QSFEGNVGMLSRLLSQYMERQRLEAQLRRQSQHDALTGLPNRKYLSERLEKQLEH----KQPLAVLYIDLDRYKAINDTLGHQAGDQVLVEMARRFKDTI
GPGNIASRVGGDEFILVLLNQNDKKVEHIARQVLAAAERPFILQERAHFLSASIGVSLSPQHGTDAGTLIKRADAAMYTVKSEGRNDVRFFSPDLKSAKV
AQVQLSSEFPLAIERGEVELHYQPVISSFDLQVVGMEGLIRWRHPTQGLLLPDQFLPSAEQSNAMKQLASWTIRRALQDRQKLDLHRYGNLVVSVNISPN
QINEDRFLAQLKGMLDEYQVRPEMLRLELTENTLIEASSRTIAQMTALRKLGVQVMIDNFGTGYASLSYLRNLPVSGLKIDQGFIRGLPDDRGNAAIMQA
IMTLAEKLKLQVIAEGVETAQEMHALRELGCRMMQGHFISAALPPQKLSEYLKKREL---
>tr|U2DQK3|U2DQK3_9BACT Regulatory components of sensory transduction system protein OS=Haloplasma contractile SSD-17B GN=HLPCO_003137 PE=4 SV=1
----------------------------------------------------------------------------------FKEMVKSSPTAIAILDED
ITVVDVNEQFMNLFQYKRVDVLGKN---LKNYIVPEGCKDESSKKGDTLMDGFVINEEVVRKRKDGKLLDIELVAIPIL-YNGKITGIVVKYIDITEKKK
YIKQLELYKKVFEYSNEGIVIINDELKVEWINKAYTDMSGFQLGDIKGVEAKILENSITSNDFLCNLRDCLLKTGTWSGEIYTRNKDQKLKPLALNVFTI
EDDFNRVTNYVAILKDLSEIKIYDEKLKVLTEKDIVTSLYNRKFFINKVNTLLEQN--RNEHFSLLFLDIDEFKRINDSQGHYIGDKILINFSSRIKRTL
GENDLFARYGGDRFVLLLKECSLNRYSLVAKKILDSLYSPFKIDNKQYYVSTSIGVSKYPTNGTHAEELIRNSEIAMETAKESQENLIQVYSHGMKEHVD
DALYIVNKMRQAISLGEFNLFFQPIYDLKTNELVSAETLVQWRDKQSPPSQPGSFVSVAEQTGEVHRFGDWVLQRVCQTITHLKKDGIVPVPVSINVSVK
QLENTFFADSFKSTLERYDLIPTDIEIVISEHVVITKQDDLDKTIKKLSKMGVPIIVNDFKLGYNWLKHLDKLKVKGVRINHKFLDITDDLSKNVDLLRT
VLHIANVFDLRVVIEGIKTEDELAIVKALNCQYGQGTILHPPVAAEKFKKILT-------
>tr|A6TN79|A6TN79_ALKMQ Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Alkaliphilus metalliredigens (strain QYMF) GN=Amet_1448
----------------------------------------------------------------------------------FDTLFLDFPYGVVVLDEN
KKVRNVNSQYATLFQYRTEEIKGET---ISGFISPSQMDNQVEANIERVYKGQVIRCEGKRRRKDGKLIDVEIFCYPII-NHQVIIGAYLIYIDISKNKD
YEKELRLFGKILENNTEGVIITNEQGIIEWVNCAFSEITGYSFAEIKGHNYNVFHSGIHSDIFYEDMWKQIKDKGSWSGEIWSKNKQGHIFPGWLTINSI
SNDENHTTHYVSIFKDLSDKKRIDNRMSELQEKDTLTGLYNRNYFLQKTDEYVEKYKDSGGKFSVVYIDVKGFKEINDSLGHFLGDRLLIEISKRLLHLM
DESYILSRFCGDEFVILCKPSILKEVIQFSKNIFKDIKRSFNIKNTLLHVSVNMGISRFPEDGTDAETLIRCADIAMYKAKEKLLDEPCLYEHEMAQKIE
EKFLLANHLVEAIVNNELTIHFQPIFEIDNQSVVGAEALLRWENPVLGMVSPMKFIPIAEQTGQIILVGKWVLEQVCRQIKQWKEKGLRIVPISVNISAR
QLEQAGFTQMLIDIMKKHNIESSLIELEITESISLGEFPVIIKNLKQITQYGVKISMDDFGTGYSSLGQLGLLQLDKLKIDKIFIDEITKGHKKRNLVEA
IIAMANSLDLVVVAEGIETVEQLLYLQEMGCQLGQGYLFSKPVDSSSFERFLS-------
>tr|U1KJ50|U1KJ50_9GAMM Uncharacterized protein OS=Pseudoalteromonas citrea NCIMB 1889 GN=PCIT_19174 PE=4 SV=1
----------------------------------------------------------------------------------LEQQVVLQ----------
-------------------------------------------------------------------------------LAKDVRLGFIYVLQDITVRLA
NEREQRLASTVFSTTSEGVLVSDKDNNIQMVNRAFSQITGYSSEEVLGESPALFNSGRHGPAFFKQLYRELHEHGHWEGEIWNRRKAGEVYPSWLQVSAV
FDEAHNIEMYVALFNDITSRKNHEQMMWQQANFDTLTGLANRLHFHEQFDHSLDRAKTHASRLAICFIDLDRFKAVNDTLGHHIGDLLLIEAAQRLKECT
RSSDIVARLGGDEFALLLPDIDTSDIEKIANKVLQQLAAPFELEGHETFVSGSMGITFFPDDGGDRKALLRNADSAMYKAKEHGRNCYQFYTAAMHEHAQ
ARRQLEGALHKALSNQELKVFYQPIVS-SDGQHIGSEALLRWHNEVLGLVPPDKFIPICEELGLIVTIGEWVLYQACSQAKAWCDRIQQSFFVTVNVSSI
QFQRADMAQVIARVLKE-GLAHHCLTIEITETVLADNSDNILQQLNALRDLGVELAIDDFGTGYSSLSYLKRFPLSKLKIDRAFIRDLPNDQEDRALVKA
IISMAGNLNLTVVAEGVETQPQLDFLRTLKCDYSQGYLHSKPIPALEFEHWLT-------
>tr|K9SWI0|K9SWI0_9SYNE PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Synechococcus sp. PCC 7502 GN=Syn7502_02595 PE=4 SV=1
------------------------------------------------------------------------------------------GIGVFILSKE
GYFIDASYGFSELLGYSTEELRNIQ---IESLILPERPKLQ------------TIDSRHCCITKDGQLVSLALNLFLLDQTSGKLLRYEGTVVDITEVKL
SEEALRLSEETFNYAPIGMMIKALNGQSVQVNQAIAQILGYTPSELLELTCVITHPEDLPTS--LEMRQRLLAGESYQIPKRYIRKDGTFVDTLLHVSLT
RDGNGEPIHFIDQIEDVSDRKRAEEKISYLAFHDPLTGLPNRALFNDRLNQALALASNFKTLLAVMFIDLDRFKVVNDSLGHAMGDRLLQLVAERFTRNM
RKSDTIARMGGDEFMLLLPEVKQEDVVKVAEKILKSLSQPFHLDHHEMYITASIGICLYPHDGDDGDTLLKNADVAMYRAKEQGRNHYQIFTQSMHERAF
EWMFMESSIRRAIAQDEFLVYYQPQLDLQTGKVISMEALIRWQT-ESGFIPPNQFIPIAEEYGLIIPIGEWVLRTACTQNKLWQNMGLPPIQIAVNFSAK
QFQDPQLLQKVSRIIAE-RLAPRYLEIEITESAVMKDEYAAAETLQSLKNMGVRISIDDFGKGYSSLSHLKKFPVQKLKIDAAFIREIPRNKDDAAITTA
IIAIAHTLNLKAIAEGVETPEQLEFLRALGCDGIQGYIFSPAVTTEVATKILH-------
>tr|A0A066ZRC8|A0A066ZRC8_HYDMR Uncharacterized protein OS=Hydrogenovibrio marinus GN=EI16_08775 PE=4 SV=1
----------------------------------------------------------------------------------LEKMVDKQEVAIIATDTR
GYITSFNAGAEKLLGYGAEEMIGKQ---TPHAFHIDEVKRKIEKEIGALESDMQVEGEWTYLRKDGKRVPVNLVVTPIYA-----CSFVVLVRDITERFN
AQQHLRLIGNVFNHAREGITITDIDGNIVDVNKGFTDITGYQREEVLGKNPRMLKSNLQSADFYKEMWKDISEKGFWTGEMWNRHKSGEVYAEVITVSAI
YDDKGHVQNYMGIFTDVTSIKENQKRLEHIAHYDVLTQLPNRVLLADRLQQSIIHADRNDKSLAVLFVDLDGFKEVNDLYGHDVGDQLLVKVSERMQASL
RAEDTLARLGGDEFVAVLVDLESQFCEPVLERMLMSVSEPILIGAHLVKVSASIGVALYPNDLSDADLLIRHADQAMYQAKQEGKNRFRFFDVDQDAIVK
SQTALLSEIRNAILENQFVLYYQPKADLEAAEVCGAEALIRWEHPVRGLLYPDEFLPVIHDHPLSVDLDEWVMRTAIEQWDSWHQQG-LNIPISINISAR
SLLEKDFKDRIQHCLGRFAINSSALSFEVLETTALEDVHHVGDLMRFCHKLGLEFALDDFGTGYSSLTYLRHLPARMIKIDQSFVRDMLEDRDDMAIVDG
ILKLTQAFGRDVIAEGVETLEHCQRLYAMGCPKVQGYVIARPIKSEDFPNWVK-------
>tr|Q31EA2|Q31EA2_THICR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiomicrospira crunogena (strain XCL-2) GN=Tcr_1931 PE=4 SV=1
----------------------------------------------------------------------------------LEELLQLQEVAVIATDTE
GVITEFNSGAEKLLGYSAQELVGKE---TPLKFHSKEIQARLSEALKRPVKGFQVDHEWTYARKDGVLVPVSLIVTPILDLNHPNYGVVVTYIDISDKRQ
AEERLNLAASVFTHAREGIMITDKHARILDVNKGFTQITGYEREEVLGLNPNILNSGCQSKEFYNLMWKTLFEEGHWSGEIWNRNKNGTVYPQMITITAI
KNSDGMTQNYLALFTDITSLKEQQRQLEHIAHYDALTQLPNRSLLADRLQQAIFASQRHNSLLAVLFIDLDGFKKVNDLHGHDAGDELLVELSKRMKNIL
REEDTLARIGGDEFIVVLVNLDASDCEMILRRLLESTSESVDIEGEVVSVSASIGVTFYPKDNVDADLLMRHADQAMYQAKQSGKNRYHYFDVQMDSMLQ
SQSAIQNEIQDALNKGEFELYYQPKVNLAQNIVIGVEALIRWNHPKKGLLVPIEFLPFIENHPFSVELDQWVMETALKQMSEWRAQS-LEMSISVNVSAY
FLQQKNFIQILERLLSQYDLPKFSLEIEVLETTALENISNISDLVHICRDMGVNFALDDFGTGYSSLMYLRHLPARTIKIDKSFVRDMLVDMDDRAIIDG
ILKLASVFNREVIAEGVETVAHFEALLDMGCEQVQGYGIARPMPADQVSDWVL-------
>tr|K2JIU0|K2JIU0_9GAMM Diguanylate cyclase/phosphodiesterase OS=Gallaecimonas xiamenensis 3-C-1 GN=B3C1_07726 PE=4 SV=1
----------------------------------------------------------------------------------LEQMVDLQEFSIIATDPK
GVITRFNKGAEKMLGYSAAELEGKT---SPVFLHLEEMAALLSARFGQPVEGFRVTQEWTYIRKDGSRLTVSLVVTTMRD------AVVCTFVDITERKA
VDDQLRLAASVFANSYEGIMVTDADNRIIEVNPAFCRITGYSAEEVIGRSPNLLASGRQPQGFYQAMWQQLASQDAWRGEIWNRRKSGEVYAEILAISVV
RNSQGAIQRYIGVFSDISQLKAHERELDQIAHFDPLTGLPNRRRLNDLLAQRLGQCDRYHQGLAVAFIDLDGFKPINDTYGHQAGDQFLVAMAKRLKGAL
RQQDVVARIGGDEFVVLLADVLHGLVEESLNRLLKVINEPVQMEGTRLQVSASIGVTCYPDDSGDADLLLRHADQAMYRAKQAGKNRFHRFDLERDRQQS
GYQSWLNRLEQALAEDQLRLYYQPKLDLSTGKVEGAEALLRWQHPSQGLLAPGDFLGHLLGSRLDVPLGQWVLDQALAQLGRWQSAG-LELNLSVNISAM
HLLQPDFADTLGTLLAAHQIDPRFLELEIVETAALTDLNLAARTLTQCRRLGVRTALDDFGTGYASLTYLRRLPVDRMKIDQSFVRDMLSDPNDLSIVEN
VIQMARAFNREVIAEGVETQNHARALLQLGCHHVQGYGVARPQPVDQFEAWLA-------
>tr|Q2BL35|Q2BL35_NEPCE Sensory box/GGDEF/GAF/EAL domain protein OS=Neptuniibacter caesariensis GN=MED92_04849 PE=4 SV=1
----------------------------------------------------------------------------------LEEMVDQQEWNVRT----
-GEAHLNTRWAATLGYTLDELQ---------------------------------ETWWMYVHPDDVERSR--------E------WVSGTHTEITEKKA
AEGSLLQAASVFEHANEGIMITDPEGTIQNANLAFSRITGYSRNEVIGQNPRIFSSGHHDDQYFAEMWKSLSEKGNWTNEIWNRRKDGEIFAAIQTVSAI
KDENGELLRYVSLFSDITALKKQQQQLEKIAHYDALTGLPNRVLLSDRLQQAILQAKRHKRLLAVAFFDLDGFKEVNDTHGHSIGDKLLIELAERSKQAL
REGDSLARLGGDEFVVVLQDLHSEESLPVLERLLKAISKPIFMNHTEICVSASIGITFYPQAEIDADQLIRQADQAMYVAKQSGKNRYHIFDTEHDRSVR
GHHDQVLRIHSALNNREFELYYQPKVNMRTGQVVGAEALIRWNHPENGLVMPGDFLPVIAGDGLVVEVGDWVLEQAMTQIDQWHQQG-LDVPVSVNVDAL
HLQLPDFVDRLQQMLAAHGVLPGDLELEVLETSALNDINRVSTIINECRDIGISFALDDFGTGYSSLTYLKQLPAHLLKIDRSFVCDMLDDLEDLSILEG
VLGLANAFRCQTIAEGVESVAQGEMLLMMGCELAQGYVIAKPMQAHCIADFIA-------
>tr|A0Q544|A0Q544_FRATN Signal transduction protein with a PAS, a PAC, an EAL and a GGDEF domain OS=Francisella tularensis subsp. novicida (strain U112
------------------------------------------------------------------------------------------NWSALIVDFY
GQIKFANSSSRDVFGFELV------------------------------------------------------------HKAKTIIGVGSVSIDISTIEK
IDKDKEIADYIVNNSDDSVMVTDQYLNIIYVNKAFEAVTGYTKTEALGNTPAMLSSRKHDKYFYERMWTKLKSQGAWEGEIWNRRKSGELYLTWAKILTV
KK-NSQVIYYVSVETDISKRRIRLDEIEKYAYQDMLTGLFNRYYFESHISDHIEKGARQRQPFTLMFLDLDRFKEVNDVYGHQAGDKLLISVSNRLKELV
REKDLVARLGGDEFLLFFVDMTIN-AIKKAHKVVEYIAKPYDIDDKQFIISASIGVVNYPQDGTDFEHLLKYADAAMYRAKDLGRNRFFLYNQEISDKVC
YDLKIKQVLNDAFENTYIQVLFQPQYDLKQRQIYGIEILSRINHPDLGVVCPKDFIPILQSINQMPSFDKIVLQKACQQISSNDMMLEQNFRISQNVTVP
VIMSEQYCREFIDIIKQYKISPQRFSFEVIENIAIDDYKTACKNFCLLKKEGISVEIDDFGSGYSSLSYLAQFPITVLKIDSFFVQNIHHP-REEKICRA
IISLAESLNLKVIAEGVETKHQADTLYKMGCYLHQGFLYSQPLSYEELLLKFK-------
>tr|C8VVE0|C8VVE0_DESAS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM
-------------------------------------------------------------------------------------LTKYANDIVFLLDSN
FNFIEINDKAIKTYGYSHEEFFKMK---FYNCDQEKYSEDDEVYTKIDSHDGYIYE-T-IHKKKDGSTFPVEISSRTII--AGGKKHYHSIIRNITERKK
TEAILRRYQLLSENTRDIILFVRSDGQIIDANLAALQAYGYNSEDILTLNIQNIREKATRTLINYQLR--EAVDKGIVFETIHQRKDGSTFPVESSKGAL
LEGEQ---IVVSIIRDISERKKFELQIKHLATHDYLTNIPNRYYLEESLKRYVAKA-KRGTTSALLLLDLDNFKLVNDTKGHVAGDELLIIFTKILKANL
REEDLLTRLGGDEFAVLLEGISIE-ATEIAEKLRAVIDQALSLINVRFNLTVSIGLSMVD--GSDPIQILSQADRALYIAKESGRNRVITIKGVEDTEEK
MTNQLISLIKKALRDNLFEIVFQPIVKVAHRDIIHFEALLRLKDDHGHLISPGHFIPVAERFGMMAQIDLWVLQSVIDTLRMH-----EGISIFINISGT
SLSNERLLNQFESIVLNSSVEPSRLGFEITETAAARDMIKAEQWIRKLKRLGCKFAIDDFGIGFSSFSYLRLLPVDYLKIDGSFIYNIDQETTNLALVKA
MNTVAHTLDKKTIAEFVENENILQILNELDVDYAQGYFIGIPAQIEQYVMNKNNEK----
>tr|I4D0T8|I4D0T8_DESAJ PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Desulfosporosinus acidiphilus (strain DSM 22704 / JCM
-------------------------------------------------------------------------------------LAKYANDIILLLNED
LRIVYANERAVLTYGYELDELYQLD---SIVLRPPEQREEIKHLIQDEGADGVVYN-T-IHQRKDRSTFPIEVSLRSIV--VEGKKYYQAINRDVTERKK
VENALKEQLHLINTIPNPIFYKGSNGLYRGCNTAFEEYLGLPKDEIVGKSVYDLSPKELSVLFNKPEV--QTYESSVV------YADGT-WHDVFNKASY
LNSEGVIAGLVGVIIDITERKQMEERLQYLATHDSLTNIPNRYYLEENLKRVVVKA-KRGIYSFLLFIDLDNFKLVNDTLGHQAGDNLLITLVNILKSHL
TEEDFLARLGGDEFVVLLEGASVR-GTKVAETLRRAIDNGPLSHDLSCNLTVSIGVAKID--GSDYQKILSLADTALYSAKDKGRNQVIFIDSTSKMSTL
QTSEIATLLVKALKENMFVLYYQPVFTMD-GSISHYEALIRIH-CQGQLISPNDFIPVAERFGLMPQIDQWVVKAALETLQQY-----PQIKIFVNISGM
SLEDADFLEYIETSIRESGVSPSRIGFEITETSAVKDFIRAEHWIEWLKRLGCQFALDDFGMGFSSFTYLRMLPVDYLKIDGSFVRNMDKDPTQRALIVA
INDVAHTLGKKTVAEFVENKEIFEALKSLNVDLVQGYYLGRPASLPQDIE----------
>tr|I3ZKI3|I3ZKI3_TERRK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Terriglobus roseus (strain DSM 18391 / NRRL B-41598 /
-------------------------------------------------------------------------------------VDAVHDSAVYMLDLD
GRVESWNAGAQKMKGYTSNQIIGRH---FSVEDQD--AGKPDALL-AKALQEGSYQDGW-RVRCDGSTFWAAVVIRPILSSDGTPIGFAKISRDLTEQRR
QQQALAAAER-------------ERDRL---------------------------------------------SSFLREGISLRVRNGSARDVQDSAAPI
HAHDGSVTGAVLVFQDVTPMRSIQREIAFSVSHDALTLLPNRRQFETALDDALKRTLSTGMRHTVCFLDLDRFKVVNDTAGHTAGDVLLKSVATLLTRLV
RISDVVARLGGDEFAIILEGCTPQ-AEPTLRKIMDAVSLGFVWDDRSFPVSASLGVAEMNE-KSDIATVMKQADVACYAAKTAGRNHMSVYHPDNGEVYD
HQLQVASEIRDAIHANRFTLFAQPIVSTRGDNTPRYELLLRMKGRGGEMIAPGSFIPAAERYDLMADLDRWVLTQVLEYQGAKLA-TIPRIQLSLNLSAN
SLNDAKFLPFFLDLLRRSPIPPSALTFEITETSLINNLITASAVIEQVRATGCKVALDDFGIGMSSFSYLRSFRVDFIKIEGSFVRNIQHSPVDMTIVRS
INNIAHEVGAKTIAEFVEDDEILKHITYLGVDFAQGYAVGHPEPIETLLPPI--------
>tr|D8GQ23|D8GQ23_CLOLD Predicted signal transduction protein OS=Clostridium ljungdahlii (strain ATCC 55383 / DSM 13528 / PETC) GN=CLJU_c30660 PE=4 SV=
----------------------------------------------------------------------------------------------------
-------------------------------IKSPKLYRRQSTF----IFTGAIVSINFFISANFKSVFIDVTPICMLLT---LIVLYLGMF--------
HMPKLV--IVLIENIKDIVIIVDSSNKIIDINPAGIKS--FKNMNFIGIKFNDL-LKFVNKEYTNNLK--QLNNGYWEGEIWNKKKNGKIYPKWMSITSL
KGSDGAVENYISISTDISKIKKTEDKLHSLAYYDLLTGIPNRTLFYERLERSLIRANDNKKAVALLFMDLDGFKVINDSLGHAAGDLLLKEVAARIKSSI
RKSDTVSRLGGDEFTVILENVDSEYVQAVSEVIIDKILLPYSILDREITLGVSIGIALAPYDESTVEGLMRKADAAMYDAKESGKGKYSFSSKEIEKRNQ
EILEMQIRLNAALHNKEFILYLQPQTAFDGNKIVGAEALIRWETADGKIFTPDKFIPVSENNRMIIPIGNWILEEIFKIDRILKSSGI-NIKLSINVSSK
QFENNNLVSKIKEIFKENSPQNIDLVIEITESFLMQNTEKAIQNLQKIKELGIGISIDDFGTGFSSLSYLTRLPADYLKIDKSFIDDIANI-NHKNITPS
IISMAKTLNLKTVAEGVETQEQINRLIDEGCDELQGYYFSKPLIISDFIKYIKQYN----
>tr|C6PSS6|C6PSS6_9CLOT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Clostridium carboxidivorans P7 GN=CcarbDRAFT_1843 PE=4 SV=1
-------------------------------------------------------------------------------------IYYAKDIPIFLFSPD
V-----GFYIHIIYSY--SSILIGC---YILIKSPKLYRRQSTF----IFIGTLISINFFISPKSKSIFIDATSICVLLT---LIILYWGSF--------
YMPKSI--VVLVENIKDFIIVVDSSNKIIDINPAAIKFLRHENINFIGIKIHEI-LNFLGKEYTNNLK--QLNYGYWEGEIWNRKKNGELYPKWMSITCL
KKQGGIIENYIAISTDITKIKKTEDKLQSLAYYDLLTGIPNRTLFYERLENALIRANNNKGSVALLFMDLDGFKVINDSLGHAAGDLLLKEVAARIESSI
SRSDTVSRLGGDEFTVILENVNNEDAKAAAESIIGKILLPYSILGREITLGVSIGIALSPYDESTVEGLVRKADAAMYDAKESGKGKYSFSSDEIERRNH
EILEMQIKLNKALDNNEFNLYLQPQIIFAENKIIGAEALIRWKTIDGKIFTPDKFIPVSETNRMIIPIGNWILEEIFRIDKVLKDNGI-NIKLSINISSK
QFENGNLVSKIKELFKENDSQNIDLVIEITESFLLQDTESAIQSLLEIKKLGIEISIDDFGTGFSSLSYLARLPVDYLKIDKSFIDDILST-NHKNLTSN
IISMAKTLNLKTVAEGVETEEQANRLMDEGCDELQGYYFSKPLIIDDFIKYVKQFN----
>tr|A0A074TIP9|A0A074TIP9_9RHOB Uncharacterized protein OS=Thioclava dalianensis GN=DL1_08230 PE=4 SV=1
-------------------------------------------------------------------------------------AAIQEHMIYSETDAR
GRITHINPAFCALSGYSKEELIGSF---HNIVSS---GTHDSDFWKKTIRSGKAWHGIC-NRAKDGSIYWVDSVILPLRGLDGKIERFVSIRHDVSDQKR
GERALSRMG--VEHSANEVFVDAQSLHFMLVNRGARDNLGYEAELS----------CLT--PL----I--DGTEDMLSFQTVHQRKDGSRYPC--DIALH
YARNENPPIFLAFVQDITQRRDNEEKMRHLALFDPLTELANRAHLQNYLAKALL---EPNNRLHLYYLDLDRFKQINDTFGHATGDEVLKVTSHRLRAAM
PDARLIARLGGDEFVVLHDA---DPVAIHIRSMLTTLSRPIVIDGHRHRIEASIGMARYPEDCTSTRDLLQAADIAMYDAKIRK-IGFSAYDADMKKRIK
ARQRMSERLALALDEGSLRLAFQPFVDLNSGRLVGVEALLRWTDAELGKVSPADVVSIAQEYRMLRALGRWVVGAACRAIKAWEEGYTVPCPVSINVAAE
QLEDGSIVRDIIDMCEYHGVRPDQIEIELTENVMLKAPEAAQQVVSQLQEMGVKLVVDDFGTGYSSLALLMQFSVDKIKIDNFFVADLSTDSKTLKIVEA
TIALAKGLGCKVVAEGIENERQADILQGLGCGAGQGFFFDRPLPEKVFSARWLQPS----
>tr|M8DA77|M8DA77_9BACL Signaling protein OS=Brevibacillus borstelensis AK1 GN=I532_23386 PE=4 SV=1
-------------------------------------------------------------------------------------YALDQSSIVAITDRR
GTILHANDQFCKISGYLREELIGQD---HRILNA---GFHPKEFFKATIGSGEIWRGIQ-NRAKDGSFYWVDTTIVPFLDEEGKPYQYVSIRNDITARKK
MEEEVRQSEEITENTTDMI--IDREGNFLYLSPSHETVLGYDINVGV-NNL----------IMVEAI--------SRQIEYRLRTLEQKCIWVETTITPV
MSESGNVRKLVLVCREITERKKSEQTIHHLAYHDTLTDLPNRRLFVQYLSKELNQAKRVGSKLAVLFLDLDRLKDINDTWGHDVGDLILLEASKRLKSCT
RKHDMVARLGGDEFTIVLPNITGDEVEGIVFRLQSELRKPLEVAGQSFTLSMSIGIAMFPEDGEQTDDLLKRSDTALYVVKSRGRNGYEFFDPTMEVKTL
ERILMENELRKAIAQEHFEIYYQPKKDLSTGKLTGMEALVRWIHPELGVIPPNRFIPIAEETGMIIDLGEWILRRACQQNKRWQEEGFPPLKVSVNLSAR
QLHQKNLVEVIEAILQETGLDPQWLELEITESVLVK-LEEAITILHAIRESGVQISIDDFGTGYNSFSYIKHLPIDTIKIDASFIQDIHQNQESQAIVKA
IVTIAESLNLNVIAEGVELLDQVAALSENGCDQGQGYLFSKPLPTRDFEHYLLAVQ----
>tr|L5MPK5|L5MPK5_9BACL Signaling protein OS=Brevibacillus agri BAB-2500 GN=D478_22648 PE=4 SV=1
-------------------------------------------------------------------------------------YALDQSTILAITDHR
GIILRANEQFCRISKYSRSELLGQD---HRLLNS---GHHPKSFFQKCIGSGKVWRGIC-NRAKDGSLYWVDTTIVPFVNTAGKIYQYVSIRNDITARKH
MEEEVRKSEEIAENTSDII--INAEGDFLYLSPSHKAVFEHDIDERF-HNM----------VMAYAI--------EYTVECRILTRKGDTIWTESKINPV
LDEQGNVSKLLLITRDITDRKQSEELIHHLAYHDALTDLPNRRMYVQHLSREIIQAKRFQSNLAVLFLDLDRFKDVNDSFGHDVGDLLLVEASNRLRECL
RPGDVVARLGGDEFTVLLSQLTDEEAAALADQIMNALQRPFELHGHSFNVSCSIGIALFPQDGDNADDLLKRADTALYTVKSHGKNGYEFFDPTMEAKSL
ERILMENELRKAIEQEHFQIYYQPKIDIVTGKLTGMEALVRWVHPELGVISPIRFIPIAEETGMIISLGEWILRQACRQNKLWHDQGFP-LKVSVNLSAR
QIYQKDLVDMIKNVLEETGLPPEWLELEITESIFVK-LEEATAILQQIRDIGIRISIDDFGTGYSSFSYIKSLPVDTIKIDASFIRDIHHNQESQAIVKA
IVTIAQSLNMNVIAEGIELDDQVAALQENGCDLGQGYLFSRPLATDDFDRYLRKDL----
>tr|V6MHP7|V6MHP7_9BACL Signal peptide protein OS=Brevibacillus panacihumi W25 GN=T458_10645 PE=4 SV=1
-------------------------------------------------------------------------------------YALDQSTIVAITDQR
GKILFANDQFCRISGYERNELIGQD---HRLLNS---GTHPKSFFKATIGAGQIWRGVR-NRAKDGKFYWVDTTIVPFVNQQGNIYQYVSIRSDITDRKL
MEEEVRKSEEIAENTSDII--IDKAGNCLYLSPSHRTVLDHDVEEKI-QNL----------IMEYAI--------EYTAECRLT-SGGKQIWTETKLNPI
LDESGEVHTLLLVTRDITERKHSEETIHHLAYHDALTDLPNRRMYIQHLGREIISAKRFQSNLAVLFLDLDRFKDVNDSFGHDVGDLLLIETARRLKTCV
KQGDIVARLGGDEFTILVSQLSGKHAEEIANRIIQELEKPFVWNGHEFNISCSIGISLFPDDGEQAEDLLKRADTALYTVKSRGRNGYDFFDPTMETKSL
ERILMENELRKAIEQKHFEIYYQPKMDIGSKQLVGMEALVRWIHPELGMIPPNRFIPIAEETGMILPLGEWILREACRQNKEWHEQGYE-LKVSVNLSAR
QIYQKDLVENIRQILNDTKLDPKWLELEITESIFVK-MEEATPVLQEIREEGIQISIDDFGTGYSSFSYIKSLPVDTIKIDASFIRDVHHNQESQAIVKA
IVTIAESLNMNVVAEGIELTDQAEALQLNGCDQGQGYLFSKPLAKQDFDHYLKAK-----
>tr|C0Z6C0|C0Z6C0_BREBN Probable signaling protein OS=Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) GN=BBR47_11000 PE=4 SV=1
-------------------------------------------------------------------------------------YALDQSTILAITDHK
GIILRANEQFCRISKYERSELIGND---HRILNS---GYHPKSFFKSCIRSGQVWRGIR-NCAKDGSYYWVDTTIVPFKNQAGEIYQYLSIRSDITARKQ
MEDELKRSEEIAENTSDII--INLDGEFLYLSPSHKRVWEHTVDEEI-HNL----------IFAYAI--------EYMVECRINTQRNDVIWTESKINPI
MDEEGNVTKLLLITRDVTDRKQSEETIHHLAYHDALTDLPNRRMYVQQLSKEMMQAKRFQSSLAVLFLDLDRFKDVNDSFGHDVGDMLLIEASKRLQACL
KPGDVVARLGGDEFTIMQNQLLDNEATELAEQIMYQLQRPFELDGHVFNVSCSIGIALYPQDGDNPEDLLKRADTALYTVKSRGKNGYDFFDPSMEAKSL
ERILMENEMRKAIEQEQFQIYYQPKIDIATSAMTGMEALVRWVHPELGIIPPNRFIPIAEETGMILALGEWILKQACKQNKNWHDQGYT-LKVSVNLSAR
QIYQKDLVEMIKDILQETKLSPHWLELEITESIFVK-MEEATAVLQQIRDIGIQISIDDFGTGYSSFSYIKSLPVDTIKIDASFIRDIHHNQESQAIVKA
IVTIAQSLNMNVIAEGIELHDQVAALKENGCDHGQGYLFSKPLPTDDFDQLLRQEL----
>tr|A0A0C2XY93|A0A0C2XY93_BACBA Strain MTCC 1458 Contig24, whole genome shotgun sequence OS=Bacillus badius GN=SD77_2863 PE=4 SV=1
-------------------------------------------------------------------------------------YALDQSSIIAITDQK
GRIFYVNDQFCKISKYSREELIGQD---HRILNS---GYHSGEFFKATIGSGEIWRGVR-NRAKDGSFYWVDTTIVPFLNDQGKPYQYVSIRNDISLRKK
MEEEMRRSEEITENSADLI--IDKEGNFQYISPSHVTILGHDMELKS-NPL----------ILYTEL-------MSSQIEFRIRTSRNQYKDMETRISPI
MNEDRKVKDFVLIMRDITDRKKSEKMIYHLAYHDTLTDLPNRRLFMKHLRQEIKKAKSSSSQLAVMFIDLDRFKFVNDSWGHENGDFILTKAAERIKKSL
RSTDLVARLGGDEFTVLLKGISNEELERLVKRIHLDFQKPLEIAGQLYTPSCSIGIAIFPQDGAEADELLSKADTALYFVKERGRNGYAFFEAKMEEKSL
ERILLENELRKAIQLEQFHIDYQPKIDLSKNKLIGMEALVRWNHPELGKISPNKFIPLAEETGLILPLGEWVLRRGCEQNKEWQDKGYTPLKISINLSAR
QISYPDIVRKIEEILIETKLEPEWLELEVTESIFVN-IENAITVLQQLRDLGVHISIDDFGTGYSSFSYIKHLPVDTLKIDASFIRDIHQNKESQAIVQA
VLTLSQTLGINVIAEGVENQRQLDVLREDGCSQGQGFLFSKPLSSQDFEEYLKESV----
>tr|A0A0C2TSE3|A0A0C2TSE3_BACBA Strain MTCC 1458 Contig5, whole genome shotgun sequence OS=Bacillus badius GN=SD77_3806 PE=4 SV=1
-------------------------------------------------------------------------------------YALDQSSIVAATDSR
GKILYVNQQFCKISKYEEQELLGED---HRILNS---SYHPKEFFKATIGSGKVWRGVK-NKAKDGSYYWVDTTIVPFLNDHGKPYQYVSIRNDISLRKQ
MEEELRESEEITEHASDLV--IDKDGKFFYMSPSHTPLLGDDLKLHA-GDI----------ALAAEL-------VASLLEFRIKAHHGKYNDMETKINSI
AGKDGEINRFVLAMRDITERKKADRMVYHLAYHDTLTDLPNRRLFMNSLRQEVEQAKRSSSLLAVMFIDLDRFKFVNDSWGHENGDFIITEAARRIRKSL
RSSDLVARLGGDEFTVLLKNVSDQEVEQVAKRIQTSFQEPLKVAGQNYSPSCSIGISLFPANGDDADELLNKADTALYSVKERGGNGYELFHSEMEAKSL
ERILLENELRKAIQLGQFHIDYQPKMDLSKNKIIGMEALVRWYHPELGKIPPNKFIPVAEETGLILPLGEWVLRRGCMQNKEWQQKGYPPLMISVNLSVR
QLAHPYIVEKVREILEETKLEPQWLELEVTESILAD-VGHAADTLQQLREMGIHISIDDFGTGYSSFSYIKHLPVDTLKIDASFIRDIHKNEESQAIVQA
VLTLARTLDINVIAEGVENEEQLAVLNEDGCVQGQGFLFSKPLSGEEFEKYLIEFA----
>tr|A0A094WMQ0|A0A094WMQ0_BACAO Signal peptide protein OS=Bacillus alcalophilus ATCC 27647 GN=BALCAV_0211460 PE=4 SV=1
-------------------------------------------------------------------------------------YALDQSSIVAMTDQR
GVILYANEQFCKISQYSLEELIGQN---HRILNS---SYHSAPFFKKTIGSGETWKGIR-NQAKDGSYYWVDTTIVPFLNEQGKPYQYVSIRNDITLQKQ
MEADIRKSEEITENSSDLI--LDSNMNVLYCSPSSIQFLGKRLGEAK-TNL----------HFSEGI-------QSTALEFRIQQKSGQYIDAEAKLNSI
YNEQEKSEYFLLVIRDVTARKKNERLIYQLAYHDTLTELPNRRFFIDRLRKEVQNHKHSQLQLAVLYIDVDKYKYINDSYGHEVGDLALIEVAKRIRQCL
RSSDIVARIGGDEFTILLTSLSSTEVETVSQRIIESFRDPVEIGERMVELSCSVGISLFPSDGNSVDELLKRADISLYTVKAQGGNNFLFFHSDMEERSL
ERILLENELRKAIQQEQFYIEYQPKKNIETGALMGMEALIRWNHPELGRIAPNKFIPIAEETGLIIPLGEWVLREGCKQNKKWQKQGHTPLTLSVNLSTR
QFSQPNLAEKIKSILDETELNAKWLELEVTESIMID-LENTVKTLQEIRDLGVHISIDDFGTGYSSFSYIKHLPVDTLKIDASFIRDIHVNKESLAIVKG
IVDIAQALNMNVIAEGIESQEQLNRLSEQGCSQGQGFLFSQPLSNNEFEDYLNSQF----
>tr|A0A0A3IBW4|A0A0A3IBW4_9BACI Signal peptide protein OS=Lysinibacillus manganicus DSM 26584 GN=CD29_02660 PE=4 SV=1
-------------------------------------------------------------------------------------YALDKSAIVGVTDRQ
GIITYVNDLFCELSQFSREELIGKR---HNIINS---GYHPKEFFKKTIGQGHIWTGIK-NKRKDGSYYWVHATIVPFLNENGIPYQYISIRTDITKEKL
LKEEVIKSNEIAENSVNLI--IDVDGNLDYVSPSFEKILQFNLKLEK-SNL----------SFKRDL--------TIDCECRLLTKQGDYIEVEVVISKI
EKSQYGSELILVVMRDISTKKAIEKKIHHLAYHDSLTDFPNRRSFMNQLRNVLLDRNNSKYNMSILFIDLDNFKNINDQLGHDIGDSILKKAADTIRNTI
RPTDVAARMGGDEFIVMLKNVKNEETSEIINRIMTNFRAGFSVDGEEQVVTCSIGVANYPEHGQSAEELIKNAANALTLVKTGTKNDYLFFNKTIEYQSI
ERRLLESAFRIALKEKQFYLEYQPKINLKSDQIIGMEALVRWNHPDLGTIPPGKFISLAEETGLIIPLGEWILYEGCRQAKEWQDKGLDNLVISINVSVR
QLEDPEFAKKLTQILEETKLAPEFLEIELTESVFAD-IQNTISILQEIRAIGVQVSVDDFGTGYSSLSYIKHLPIDTLKIDASFVRDIHVNEESRAIVRA
IIHIANSIGLKVIAEGIELQDQATELSIEGCRFGQGYYYSRPLKIEAFEQFMQKRL----
>tr|A0A0A3JZC0|A0A0A3JZC0_9BACI Signal peptide protein OS=Lysinibacillus massiliensis 4400831 = CIP 108448 = CCUG 49529 GN=CD30_00285 PE=4 SV=1
-------------------------------------------------------------------------------------YVINQSVIMAITDRK
GCITYVNDLLCEVSQYKRGELIGQR---HEILYS---QSYKNRFIVETVKRGQVWKGIL-SRKKDGSHYWIHTTIVPFINDENDEYQYYSISKEITKEKE
IEEDLKRSHEIAENTINLV--LETDGSFQYISPSFNSILDYDVTLMN-ENF----------TVKEDV-------EPLLMEFQILHPEGEYIDVEASIRAI
SNTSYSNDLILVVMRDIRGRKEIEQKIYHLAYHDPLTNFPNRRSFMIKLRDEILNRRKTKEKMAILFIDLDNFKSINDQWGHDMGDLVLKEAAIMIQSSI
CPSDVAARLGGDEFMVMLKSIRDQDTINVVQSILKKFQSPLFVDGQEFIITCSIGIANYPEHGRSSEELMKNADDALYSVKGQGKNNFIIFNKSIENKTL
ERRLLENALRKAIKKQEFYLEYQPKLNISTNEIIGMEALVRWNHPDLGTIPPVKFISLAESTGLIIPLGEWILRESCRQTKEWQEKGYPQLRVSVNVSVR
QFEDPYFIEKIKRILHEIGLDPHWLEIELTESVFAD-LKHTVPILEGIRNLGIHISVDDFGTGYSSLSYIKHLPIDTLKVDQSFIKDVHLNHQSKAIVSA
VIHLAETIGLNVIAEGIETLEHVEALSKDGLKFGQGYFYSRPLRCEAFEEFVTNNA----
>tr|A0A0A3HXH6|A0A0A3HXH6_9BACI Signal peptide protein OS=Lysinibacillus manganicus DSM 26584 GN=CD29_15585 PE=4 SV=1
-------------------------------------------------------------------------------------YVINQSSIVVVSNTE
GNIIYVNDLACEISNYSREELIGQQ---HAILYS---NEFQTNKQDQTLKKGQIWKGML-NEKKDGSPYWVYATVVPILNDQQKTIEYYSISTEITEEKE
FAEDAKRTNEIAENTSSLV--IDKDGLFQYVSPTFNSVLNYDTKIMT-ENF----------IVEQDV-------ESLLMDFRIRDESGEYIDVEATIRII
NNSTYSSDLYLIVMKDIRNRKAVEKTIYHLAYHDSLTNFPNRRSFMSKLSDEMMSRTKSKDKLAVLFIDLDNFKNVNDQWGHDVGDLVLKQTASIIQSSI
HPKDVAARLGGDEFIVLVKNVQSEDVITLVKKLLGKFRSPIVVNGIEHSITCSIGIAIYPDHGTTTDELIKNADDALYMVKGKGKNNFTIFDETIEHQSF
ERRLLENALRQAIIDNQFYLEYQPKLNIATNELIGMEALVRWKHPELGIIPPVKFISLAESTGLIIPLGEWILRESCRQTKELHDKGYGNLSVSVNISVR
QLEDPYFIEKVQKVLDETGLDSKWLEFELTESIFAD-LKNTVSILQEVRNLGIQISVDDFGTGYSSLSYIKHLPVDTLKVDQSFVKDIHVNQESQAIVLA
VLNLAKTIGLNVIAEGIELEEHVDKLSEKGLLFGQGYYYSKPLKSDAFEEFINNNN----
>tr|U1XAS1|U1XAS1_ANEAE Diguanylate cyclase domain protein OS=Aneurinibacillus aneurinilyticus ATCC 12856 GN=HMPREF0083_00261 PE=4 SV=1
-------------------------------------------------------------------------------------WALDVSTIVAVTDLK
GRILYANDKFCEISGYDRNELLGQN---HHILNS---GYHNKTFFRKTIGEGDVWNGIR-NRAKDGSIYWVNTTIVPLMDDQGKPVQYISFRNDITRGKE
AEEKLRQALKRTVNAHNFVFKRRTDGSFVYVLKLAKQ-LGLTTKTYG-KTA----------ILVRNY-------VTYSY-----RFKERD--FQTSL-SP
IIEEGRIIEIIGSTSEITELKRAEETIRKMAYLDPLTNLANRRMFTEDLSKALYEAEASSFEVAVMFLDLDRFKQINDTLGHTIGDLLLQAVADRLRMQN
KEHCRIYRLGGDEFVVLLPRISDTDAERVAEHILELFQTPFKLEHYELFATCSIGISTYPFAGEDIESLMKNADTAMYSAKSSGRNGYRLYTPKMNEEYD
EHLQIEVHLRKAIEKNELQLYYQPKVDTNSGQLKGMEALLRWIHPELGVVSPGRFIPIAEETGLIVAIGEWVLRTACEQNKRWIESGYMPLPVSVNVSAL
QFQQPTFVDKVGSVLRKTGLAPCYLELEITENSMINDVEENIATLLRLREMGVYISIDDFGTGYSSLSYLKRFPIHALKIDQSFVRDVVVDKDNAAIVKA
IIDMAHHLKLKLVAEGVEDEATLSFLRSERCDEVQGYFFSCPVPTEEFERILSGEK----
>tr|C0ZBT5|C0ZBT5_BREBN Probable signaling protein OS=Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599) GN=BBR47_22670 PE=4 SV=1
-------------------------------------------------------------------------------------NALDESSIVAITDDK
GVITYVNDKFCEISRYEVDELVGNT---HRVINS---RYHSKSFFKETIKQGRVWKGVK-NRAKDGTEYWMNTTIVPFLDDRGVPYQYVSIRTDITDRIE
AETALAEALQRTVQNQNCVFKTDQRGNITYTLKIAEE-LGLTSRMLR-KTS----------QMESYF-------VTFEL-----KLSGND--YYITL-SP
IEENGEIVEMVGSMIDITERKKAEETIRYMAHYDSLTNLPNRTLFHEKLAEAMLKAKQKDEKIGVMFIDLDRFKNINDTLGHSIGDVLLQAVANRLICCL
RKEDSVSRLGGDEFAIFLTGVTHREAGEIAQRIITSMSESITLDHIEIFITPSIGISMYPDDGDDIEALLKHADAAMYLAKEQGKNNYQFFSEELHQVLA
KKLQLERELRKALDEKQFTLHYQPKIHLQTGQIIGMEALIRWDHPDLGLIPPIQFIPIAEETGLIVPLGEWVMRTACQQTKAWQEAGFTQLAVAVNISLR
QFMQNNLIEMITSILEETGLAPQYLELEITES-MALNVDYTIRILNRLKALGVSISIDDFGTGYSSLSYLSQFPIDRLKIDQSFLRNLN--PQNQAIIKT
IIHMAHNMKIAVIAEGVETHEHVDFLKEQLCNEVQGYFYSKPLPTKEIDSFLQVNR----
>tr|A0A098M9H1|A0A098M9H1_9BACL Uncharacterized protein OS=Paenibacillus wynnii GN=PWYN_04430 PE=4 SV=1
-------------------------------------------------------------------------------------YALDESTIVAKTDAR
GVITYVNDRFCEISKYSREELIGKT---HRVINS---GHHPKPFFHQTITSGNIWRGVK-NKTKDGHYYWVTTTIVPFVK-DGVPIQYIAIRTDITDQKH
KEELYRDREQTTLNSGDGI--TDQYGKVTFLNPIAESITGWTFDAEG-LDI--------DTIENPVY-------VGIDMNTLLINKKGIEIPIDDSAAPI
IDQNGQVIGVVLVFRDMIERKRYEEKLKYNALHDMLTGLPNRRLFRDRLTKALINANRNHENLAVMFLDLDRFKFVNDTLGHDVGDLLLKNTADLLSSIV
GSSGTVSRIGGDEFTIILEKVTKDEVAVNAQKIVDVFSYSLLNNAYEVIITLSIGISIYPSDGADLETLIKNADTAMYFAKEKRLNTFQFFTPDMNEILN
HKRIIENALRHAIERNELELYYQPKYDLNTSKITGVEALSRWNHPERGTIPPAEFIPIAEETGLIVSIGEWVIREACKQLKKWESQFHFLLPLSINLSIR
QFYDKNLILTIMRILEETGVKPHYLELEITES-IMERADESLLILFQLKELGFIISIDDFGTGYSSLSYLKKLPIDTMKIDRSFISETDENHKDYKILST
IIHLAQSMEMNIIAEGIESEQQETALIQLGCTEGQGFFFSHPLNAEDFNEFYRTSI----
>tr|F9DU01|F9DU01_9BACL Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sporosarcina newyorkensis 2681 GN=HMPREF9372_2282 PE=4 SV=1
-------------------------------------------------------------------------------------YTLEQAAIVSITDPR
GTIQYANEKFEKLSKYPLKELIGAN---QRIVNS---DYHDASFFKATIGSGKTWRGIR-NQAKDGSYYWVDTTIVPFLNDKGKPYQYVSIRYDITARKL
MEEEIRKNAE-ITTNASDFIAIDRDGKFQYLSPSFENLLGYSLSLYSDTLYSILYKK----KVER---------KIAQFKGFHRKAIGLEYSMLAKLNEV
RGSIDYEDQLLVVMHDVTERVKSEEKIKHLVYNDQLTSLMNRNSFREQLALAFERAKTRKQVFALVHINIDRLRYANDLLGHEAGDYLLSMVGERLKKKT
GPESLLARIAGDEFAFIVTGL--DEIYNYAEEIRLYLEQPIQVGQQTYSLSISCGISMYPEHANQPSELVTKATLALGKVKTRGGSDSEMYEHGTSKMSL
ERILLENEMRKSIQQQHFYLEYQPKVFLGTGELTGVEVLVRWNHPDLGVIPPMKFIPLAEETKIIVSLGEWILREVCKQAAAEIEAGE-FCKFAVNVSTV
QMKEEGFADSVLSILEEFQVPANMLELELTESSFMD-TEGMKESIQKLRSIGITVAIDDFGTGYSTFSYIKELPADTLKIDMAFVRDILENENSQAIVKA
IVTLADTAGLNVVAEGIELNEQAKMLYNLGCREGQGYYFGRPTTLLEAKKSEL-------
>tr|A0A0A8JG04|A0A0A8JG04_BACSX Diguanylate cyclase/phosphodiesterase with pas/pac sensor(S) OS=Bacillus sp. (strain OxB-1) GN=OXB_0864 PE=4 SV=1
-------------------------------------------------------------------------------------NALNQSSVVVVTDPA
GKITYVNDKFLKLSKYSSEELIGKT---HRVVNS---GHHPKDYFKQTIRSGRIWRGIK-NQAKDGSAYWVNTTIVPFLDKSGKPYQYIAIRTDITARKE
AEESLQEALKQTVKNQNAIFKLDEDGEIVFTLKIAEK-FNFTANLNS-NLK----------NVYKHL-------TDFEL-----SFRDFT--FLFYL-SP
IFEGGHVVEVVGTASDITERKQAERTIERMAYYDSLTGLPNRRLLKECVKEAIQKAKLNEEELAIMFIDLDRFKNVNDSMGHFVGDQLLQSVGERLKTCV
RDNDVVARLNGDEFVILFPSTNAAQVESVAARIIEEISEPFQFNSVAVYISGSIGISMFPQDGADYDTLLSNADSAMYLSKEVGKSTYQFFTKELREAML
EKTLLEMELRQALKKGQLHLHYQPQFNTKTGQLKGLEALARWDHPSLGPISPGRFIPIAEETGLILPIGNWVMRTACMQVKSWEKRGLPSVRISVNVSAR
QFMQPAFVSQVQNILHETGLHPKKLNIEITES-MTMDVDHCLSVLSQLNEIGVSVSIDDFGTGYSSLSYLGSFPISHLKIDQSFVREMS--PKNRVIVKS
IIDLAKNLNLNVIAEGVETEEQALFLSNLQCDEVQGFLFSKPLPVKEAEELLIEAQ----
>tr|D3FPU3|D3FPU3_BACPE Putative signaling protein OS=Bacillus pseudofirmus (strain OF4) GN=BpOF4_07225 PE=4 SV=1
-------------------------------------------------------------------------------------HALNEASIIAITDNK
GTITFVNDMFCKISKYDRDELLGQN---HRMLKS---SYHSSDFFVRTISRGKVWRGVK-NKAKDGSFYWVHTTIVPFLDSRGKPYQYVSIRTDITERKC
TEELLKRSLDSNRKLDHHH------TP-SQTT-IHDD--------LG-QSI------------------------DESM---------------------
-AAYPEIRQLMTQFNEMIRINQARKRIEHQAYHDALTGLPNRYHIEEYLKRSIEYAKVNNSSLTLLYLDLDRFKLVNDLLGHQVGDLLLKEVAEKLSQTI
CENGMIGRQGGDEFLIVLEDMNEEEVRAIAGRILDCLSYPFVYAGKEFFISPSIGISMFPKDGNDIESMMKNADTAMYMAKERGKNNFQFYSSEPSSLLS
RRHLLENKLRTALKNKEFILNYQPQVHLNSHELRGFEALIRWNNPELGLISPEEFIPIAEETGIITDIGTWVLKEACRQNKAWQEQGFVRVPVSINVSSQ
QFRDPEFVWNVLNVLKESKLHPQYLEIELTES-TTHHFVHTVEKLQLIKQYGIKVAIDDFGTGYSSLSALDQLPIDILKIDRSFIKHILTNPNKAAIAKT
IIDLGHNLDFKIIAEGIEEPSQADFLNEHQCHIGQGFLFHPPLNPTDVARHYQHLF----
>tr|K6D7A7|K6D7A7_BACAZ Signaling protein OS=Bacillus azotoformans LMG 9581 GN=BAZO_05175 PE=4 SV=1
-------------------------------------------------------------------------------------ALD-SSTIVAVTNKA
GIIAYVNDKFCEISQYSREELIGST---HRLLNS---GYHSPNFFKTTILSGKIWCGVK-NLKKDGSYYWVHTNIIPIINVTNQVEQFIALRTDITKGKE
AEEELRKVID-IRSLDNMVFKIKRYGDFTLVEGKLSKI--------------------SQKMANEALR--KCE-AAFRGEKHSIKHHIE---LY-TTLSP
IIENGTIIEIIGNSNDITLLELAQKEIHHLAYHDDLTDLPNRRKLTKDLQEKLNHI--SNQKFAALFVDIDRFKQINDTLGFNRGDKLILELSQRLKQFI
SGLGTIYRSSGDEYVIILEKYKNSILSRQVQELLKIVEEPMLIDGYELMITCSVGVTTFPNDEDSAEKILNRVETALKHCKLNGRQGFIFYNEEMAQNTK
ERLNLEINLRKAIINDELTLHYQPKYILNSNQMDGMEALVRWYSPVYGFVSPNEFIQIAEDTGLIVQLGEWVLYNACKQNKEWINNGYPPRRVAVNVSAI
ELLRPNYVERVKRILKETKLDPQYLELEITENSVMRNLEKGIQILQELKSLGIFIAIDDFGTGYSSFGYLKQLPINILKIDKYFIQEIDKSEIDANIVKS
MIQLGHTFHLKVIAEGVETKRAAEILRDLNCDIVQGYYFSKPIPADMFEKLL--------
>tr|D6Y0H6|D6Y0H6_BACIE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS
-------------------------------------------------------------------------------------DALDEFAVVMITDTN
GVITYVNNRACELSGYSRDELTGTT---PRILNS---GYHPKSYFRETIKAGRVWRGIC-NQTKHGDHFWSRATIVPLRNEQGVIHKFLALRHDITDRVH
AEAALQDALD-VKNLQNGVFK---------KKRDQADDIVFTLEGQIAAGYQMTTKDIE--HVDRALQ--QGAERF---ELTLNDQVYLIYLT--RFETA
FA---G-VEVAGSIIDITDQKLKEQQIQTMAYYDSLTQLPNRRSFELALKDSLQMPLANGEKVAVFYINLDRFQSVNETLGHAVGDRLLKKVAIRLKTLF
DQGAVLSRFSGVDFAVMVRL-TCDGIKHEAERIHAALREPVILDNMELYTSPAIGVSLAPDHGTDWKTIIQYADAAMNRTKQLPGQAFYVFDSELEASLL
RRLAIEQELRIAIEEGTLDLYVQPKVKAKTYRLSGGEALLRWHHKELGTVSPEEFIPIAEEFGMIQDLGYWVIQEGARRLKSWHDLLTY-LSLSVNVSIR
QFMQPTFASDMQGVLDETGVDPRKLELEITENV-TANMEMTRKVMLALKEMGFIVSIDDFGTGYSSMQYLQELPFDRVKLDKTFVMDLS--KANRSIMQA
TLKLASALSMSTVAEGVESFAHAAFLSEWGCEELQGFYFSHALSEADFHQYWIIPE----
>tr|W1SUU1|W1SUU1_9BACI PAS/PAC and GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Bacillus vireti LMG 21834 GN=BAVI_00600 PE=4 SV=1
-------------------------------------------------------------------------------------IFDTLDVAIWSHDLK
SDKLLITPGIEKLYGYSYKDFYNDF---DL-VIYPDDLYIVQAREKA----GETVTSYRIIR-PDGEVRWIQDRGFPTLDKRGNFVDFNSVLFDITDRKE
SE-------DLVEMSPDIIA-VVGSKKVEYMNEAGWKLVGATSDEVIGESA----LKFA---------------ERVRFEFQAKRLDGETIDVE-MAATS
IFYEGRFA-VQVVGRDITERKKTEKTIQNMAYFDSLTGLPNRNRFRHHLNEALKQ--QADQMLAVLFLDLDRFKIINDTKGHSVGDVVLQKVANRLELAV
QTGGFVSRQGGDEFIILLEDIDKEKTTKLAKQILNEFSYPLEVNNQEFYVTPSIGISIFPIDGMDEETLIKNADTAMYQAKERG-NSFCFYSSNLNGISI
RKMELENGLRKALEQNQLMLYYQPQVCLATGKLVGIEALIRWQHPELGFIAPSEFIPLAEETGLIVPIGKWVLQEACKQRKAWENAGFHNFPIAVNVSVR
QFEDDYFVEYISNLLAEVGLEANHLELEITESI-MQNLENSMIILNQLKELGVLLSIDDFGTGYSSLSYLLHLPIDKIKIDKSFVDDILYHSNQGIMVKT
IIDMGLNLNFAVIAEGIETDEQLSFLKKNDCRTGQGYLFSRPIPAEQMDEYLFNRK----
>tr|K6DNH4|K6DNH4_9BACI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor domains protein OS=Bacillus bataviensis LMG 21833 GN=BABA_08026 PE=4 
-------------------------------------------------------------------------------------IFDTLDVAIWSHDLK
SDTLLITPGIEKLYGYSYIDFYKDL---DL-VIYPDDLHLLSDREKG----GKTVTSYRIIR-PDGEVRWIQDRGFPTLDLDGNFVDFNSVLFDITDRKE
SE-------DLVEMSPDIVA-VVNQNRIEYINEAGCMLIGAKYEEIIGQSP----LKFA---------------KRTRLEFQIRQLNGETIDVE-MASTT
LFYEGRFA-VQVVGRDITERKVAERTIKSLAYHDSLTGLANRNRFRDYLNKVLNRS-HTNKMLAVLFLDLDRFKIINDTKGHTVGDRILQKVANRLEIAV
QEEGFVSRQGGDEFIILLDDTDKEKAAIVAQRILYEFSKPFEVNNQEFFVTPSIGISLYPTDGNDEETLIKNADTAMYQAKERGKNNFQFYSSNLNGLSV
RKMELEIGLRKALENNQFTLHYQPQMSLVTGKLVGLEALIRWQHPEHGFIAPSEFIPLAEETGLIVPIGKWVLWEACNQRKAWESIGLCDVPIAVNVSVR
QFEDDHLIEYISTVLDEVGLEATQLDLEITESI-MQNFENSTVILNQLKELGVLLSIDDFGTGYSSLSYLKYLPIDKIKIDKSFVDDILYHSNQGVMVKT
IIDMGMNLNFTVIAEGIETVEQLSFLKENACKIGQGYLFSKPLPACEMQNYLLNRK----
>tr|I3E8W9|I3E8W9_BACMT Uncharacterized protein OS=Bacillus methanolicus MGA3 GN=BMMGA3_09025 PE=4 SV=1
-------------------------------------------------------------------------------------IFDTLDVAIWSHDLK
SDILLITQGIEKLYGRSLNEFYQDH---NL-VIFPEDRYVLDEREQA----GEPVTSYRIIR-PDGEVRWIQDRGIPKLDENGAFVDFTSVLFDITDRKE
SE-------DLVEMSPDIIA-VISNEKIDYINEAGCKLVGASRDEIIGQSI----FKFT---------------STKRFEFQVFGLDGHSIEVE-MSTMP
IQYEGRRA-IQIVGRDITERKRAEKTIHKMAFYDALTGLPNRNKLRQHLNKLLTN--PGNQMLAVLFLDLDRFKIINDTKGHSTGDLLLQKVAKRLKSAV
PSDGLVSRLGGDEFIILIEDIDKKKVTEIAKRILDAFHAPIEIDQQEFFVTPSIGISIYPTDGEDEETLIKYADTAMYLAKERGKNNFQFYSSNLDDLTS
RKMEIENGLRKALEQNQLMLHYQPQVELATGKIVGVEALIRWKHHELGMISPSEFIPLAEETGLIVPLGKWVLREACEQNKAWQNSGLPPIPIAVNISVR
QFQDEQFVDFIMNTLDQVGLDPHYLELEITESI-MQNIEKSTIILNQLKELGVKLSIDDFGTGYSSLSYLKHLPIDKLKIDKSFVDDIIHHMNQGAIVKT
IIDMGHNLQYTVIAEGIEKEEQVKFLRENSCKIGQGYFFSKPLPPEKMLELIKSEH----
>tr|A0A0A8X4B4|A0A0A8X4B4_9BACI Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Bacillus selenatarsenatis SF-1 GN=SAMD000
-------------------------------------------------------------------------------------IFDTLDVAIWSHDLK
TDTLLITSGIEKLYGHSSEEFYNDN---TL-VIHPEDLRILADREDR----GEAVTSYRIIR-PDGEVRWIQDRGIPVIDENGNFVDFTSVLFDITDRQE
SE-------GLVEMSPDLIA-VYSRGKLDYINEAGCKLFKAKSEELIGQPI----SKLI---------------EKLWFEFKATQIDGQKIDVE-MSAMP
ILYEGRMA-EQIVGRDLTQRKKAEKTIKYMAYYDVLTGLPNRNMVRKHLNAALSN---GNGNLAVLFLDLDRFKIINDTKGHRVGDLLLKVVATRLKNAV
KEQGLVTRQGGDEFIIVLKDFGKEQVVEVAEGILNEFNEGITIEGQEFFVTPSIGISMAPEDGQDEETLIKHADTAMYLAKDRGKNNYQFYTDKLHGLSS
RKMELENGLRKALEQNQLMLHYQPQVNLETGEIIGVEALVRWVHPEKGIISPAEFIPMAEETGLIVPLGKWVLEKAAAQNKEWQEKGYSPIPMSVNISVR
QLQEDTFIDCVKQVMFDTQLAPNYLDFEITESV-MQNSEKTALILDQLKELGVTLAIDDFGTGYSSLSLLKHFPIDKIKIDKSFVDDITQHSNQGAMVKT
IIDMGHNLKFSVIAEGVEEQEQVEFLLKNGCVVGQGYHFSRPLPVEAIEELFMENK----
>tr|A0A098EUA5|A0A098EUA5_9BACI Diguanylate cyclase/phosphodiesterase with extracellular sensor OS=Bacillus sp. B-jedd GN=BN1002_00317 PE=4 SV=1
-------------------------------------------------------------------------------------IFDSLDVAIWTHDLK
TNHLMITPGIEKLYGFSLADFYRDH---EL-VIHPDDLPFLPERELR----GEAITSYRIIR-PDGEIRWIQDRGIPTVE-KGKLVDFSSVLFDITDKKE
SE-------NLVEMSPDIIA-VYSRGQIDYINETGAKIFGAGSEELIGTPL----SGLI---------------DNISLEFQAVRMDGQLIDVE-MVSMP
IFFEGRAA-RQIVGRDITARKMAEETIQNMAYYDGLTGLPNRNRFREKLNQALSG--NREQKLAVLFLDLDRFKMINDTKGHTVGDQLLKEVANRLGQTV
GESGIVSRQGGDEFIILLEDIDRQGISKVAKRILNSFANPFAIQQEEFYVTPSIGISIYPSDGMDGETLIKNADIAMYVAKDRGKNNYQFYTSGLQGLSS
RKMEMETGLRKALDSNQFELYYQPQVELRTGNIIGIESLIRWKHPERGMVPPSEFIPLAEETGLIVPIGNWVLKEACRQHRKWMDNGYFPMVMSVNISVR
QFQDDDFVSSVKRTLEETGMDPGSLELEITESI-MQNFDRSIRILTDLNELGVKIAIDDFGTGYSSLSYLKHLPIDTIKIDKTFVDDME----DDSMVKT
ILDMGLNMRFHVIAEGIERREQMDLLVAHGCTVGQGYLFSRPLPANQIEGSLAKEI----
>tr|A6CQL8|A6CQL8_9BACI Uncharacterized protein OS=Bacillus sp. SG-1 GN=BSG1_13231 PE=4 SV=1
-------------------------------------------------------------------------------------IFESVDVAIWSHDLK
SNNLLITQGIEKLYGREMEDFYKDF---YL-VILPEDLQSLEGRQEN----GETCTSYRITK-PDGNVRWIQDRGIPTLDEKGNLIYFSSVLFDITDRKE
SE-------DLVEMSPDIIA-VIRDGKFVYMNAAGSRVLGAKDDSLIGEDI----LKVA---------------GNLIFEIKATRFDGVEIDAE-VSAMP
ILYGSKPA-IQIVGRDITERKKTEETIREMAYYDTLTSLPNRNMFKLRLNKLLES--SPSTSLAILFLDLDRFKVINDTKGHSTGDRLLVKVADRLTDVL
NKEGEVFRQGGDEFILLLDNSDKEKAASLSVRILQSFTKPIDISGQDFFVTPSIGISMYPDDGMDQETLIKHADTAMYLAKDRGKNNFQFYNRNLNRNTT
RKMDLENELRKALELQQLVLFYQPKVNLETGEVLGVEALIRWEHPTLGMVSPAEFIPLAEETGLIVPIGKWVLWEACRQSKEWKKSGIGCISVAVNISVR
QLQDDDFVQHVQQAMKDTGLEPSLLELEITESI-MQDFEKSSRILNKLKNLGVTISIDDFGTGYSSLTNLRFLPIDHIKIDKSFVDDIIDHSKNGSIVKT
IIDLGHNMNFNIIAEGVEEEEQVDFLLQNSCSIGQGYFYSRPLPPEQLEAYIRESQ----
>tr|U5L5A8|U5L5A8_9BACI Histidine kinase OS=Bacillus infantis NRRL B-14911 GN=N288_02695 PE=4 SV=1
-------------------------------------------------------------------------------------IFDTLDVAIWHHNMK
SGRLMITSGIEKLYGFPRESFYRDP---DL-VIHPNDVSVLNEREQQ----GEPVVSYRIIR-PEGGIRWIQDRGIPVLDKKGRLIEFSSVLFDITDRQE
SE-------DLVELSPDFIG-VISGNVIVYINEAGCRLIGASSEQLLGKPI----INFV---------------GKRRFEVQAKRLDGVLVDVE-VSSMP
IRYGGREA-VQVIGRDITERKKSERTMEYMAFYDTLTGLPNRNEIMKQLQGILNS---GKEKAAVLFLDLDRFKIINDTKGHSTGDLLLKKAGIRLEDTV
GSLGLVARQGGDEFIILFEEKEKQQIEGAARAIIEQFNKPFILEGEEFYITPSIGISLYPEHGTDQETLIKHADTAMYLAKERGKNNFQFYTSSLEGLAS
RKMALENGLRKALDRGELLLHYQPQIDLKTGKLKGTEALVRWQRPDGHLVPPGEFIPLAEETGLIVPMGKWILRTACEQHKRWKLEGAGSVPIAVNISVR
QLEDPEFIMYVKTVLSSCDIEPGCLELEITESI-MQNIEKATIALNELKKIGIRLSIDDFGKGYSSLSYLKHLPIDTIKIDKSFVDDILDPAQNGSLVKA
IIDMGLNLNFSVVAEGIEHKEQAEFLLENNCPVGQGYYFSRPVTGEVFKEFIKSLQ----
>tr|A0A074LIJ2|A0A074LIJ2_9BACL Uncharacterized protein OS=Tumebacillus flagellatus GN=EL26_17815 PE=4 SV=1
-------------------------------------------------------------------------------------FVNNSTVAFIVIDLT
GHIVRVNDTFEHIFGWTADEAIGQQ----LPRLLP----EFQQRLKH----SFTGTAEEIRLCKDGTLFTASETITPILDDSGQVTSYACILRNISDRKA
DERRLKVSEQLFENNPNAIY-VDLQGRFTELNPAVETITGYT-EELLYRDH----TMLL---------------TKQEVEATIVHKDGRLVDIS-VISLP
IDVDGEMIGFFCIAKDITVQKQAEQLINHMAFTDCLTDLPNRRLFRNRLTESIETAEQNGDKLAVLFIDLDRFKVINDSLGHAFGDHVLQAVSERLQSCV
THEETLCRMGGDEFTLLMPNIQGQDAIDMSKKIMEVIRRPLNVDGNEVHVTTSIGIALYPENGRDADTLMKNADIAMYRIKEHGKNNFQLYTDVMNEDAI
QHLQLERELRKAIEREEFVLHYQPQVNVSTGQITGMEALVRWQHPERGLLSPIHFIPLAEETGLIVPIGEWVLKKACEDGQRWLQEGRKPMRMAVNLSLI
QFQEQDLVEKIHQILVDTGLDPRYLELEITESIAMNNVEQVVAKLEQLVNLGVQISIDDFGTGFSSLSYLKKFPIHKLKIDRSFITDITSDPDDASIVSA
IVAMANSLKLDLIVEGVETKDQQLYLHRLGCFEMQGYLFSRPLPAQMLEQLLQNWL----
>tr|A0A011PJB8|A0A011PJB8_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-12 GN=gmr_9 PE=4 SV=1
-------------------------------------------------------------------------------------AVEQSPVTIVITNRN
GDIEYVNPSFTRVTGYSRLEAIGQN---PRILKSGEV---PGEVYQQTLLDGKVWTGLLHNKRKNGTLFWESVSIAPVFGDHGEVTHYLAVKEDVTERLL
AEKQLRESEELFEDAKDPLLLLKNGA-FVDCNTATLE--GYPSEEFL--G-------LGGHLTEQRLR--LLASGHWQGEIWDRRQDGTVYPKWLSISTI
RGADGSVENYIGSFVDISERKAAEERIRHLAHFDTLTHLPNRSNLQGRLEQALAAARREGGSLAVMFLDLDRFKNINDTLGHHVGDALLLEVSQRLTGSV
RASDIVARLGGDEFVVVLSRAD--AAERVAMKILHALSQPYQIDGQGMHTTSSIGIAVFPGDGDTVEVLMRNADAAMYHAKSAGRNNVQFFTASMNQAAR
DRRQLEEDLHLALQNDEFVLHYQPQVD-SRHRVFGAEVLLRWQHPQHGLVPPGKFIPLAEDTGLIVPIGQWVLATACAQLAAWRGDRAGELQVAVNVSAR
QFRQADFVDQLQALLQRSGADPTRLKLELTESLVLDNVADTIARMNAIKQLGVSFSMDDFGTGYSSLSYLTRLPLDQLKIDRAFVSRLPDNQSDAIIAQT
IVTMGRSLGLKVIAEGVETAAQCEFLDRHGCHGYQGFMFGRPVPVDEFTRLLPPAP----
>tr|S6B1F2|S6B1F2_9PROT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sulfuricella denitrificans skB26 GN=SCD_n00685 PE=4 SV=1
-------------------------------------------------------------------------------------LAQISPAGIFHADTQ
GACDYVNERWSEITGLSIEESLGDG---WMLALHKEDRERTLAL--REAMSTMQPKPEWRMQRHDGTVRWAFGEAATELDAQGRIAGFIGIVNDITERKQ
AEIKLRESEETLQTSIDGFWIASSDGRILDVNDAYCQMISYERELLN--M-------RIGQQVEEDLR--IAAKGYWQGQMWNRRKNGKIYAEWLTITAV
TAPDGRITHYVGTFSDITQNREAEAEIHRLAYYDPLTLLPNRRLLQDRLGQVLAATVRNGHCGAILFLDMDNFKTLNDTRGHDIGDLLLVEVAQRLKTCV
RGVDTVARLGGDEFVVLLEDLSGFEAKLVGDKVQEVIARSYHLKGCEYYCTTSIGISLFRDNNVTVDELLKHADLAMYQSKNAGRNTQRFFDPAMQAALD
EHSALETDLRLALKRQQLRLYYQPQME-STRGLVGAEALLRWVHPERGLVEPGDFISIAEETGFILPIGYWVLETACAQLKAWEGNRTHELQLAVNVSAR
QFRQPDFAVQVQQVLAQSGADPTRLKIELTESLVLDNVSDTIIKMQALKAIGVGFSMDDFGTGYSSLSYLTRLPLDQLKIDRSFIRDFGSDANGAAIVQT
IIIMGKTLGLNVIAEGVETVAQRDFLDRNGCHAFQGFLFSRPLPLADFEQFMNLNA----
>tr|D5CTS9|D5CTS9_SIDLE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sideroxydans lithotrophicus (strain ES-1) GN=Slit_2013 PE=4 SV=
-------------------------------------------------------------------------------------LIEDSGDGYWVVDLK
GRLLEVNQVYARMAGYSADELVNRH---VSELDAQDDEEAVKARMEA-----QGHDRESRHRHKKGHLF-EVDV-AINFIHES--NRFLVSFRDISERNM
YEQALRESEELFENAGD--LAYGTDLNG-AFTAVSESVTGYGRELIN--A-------PIGRRFETDLR--IAATGSWKGEIWDRRKNGETYPKWLTISAV
RGNDGCVTHYVGSHVDITERKAAEEQIRRLAFHDPLTHLPNRQLLLDRLQQSLISTARNGKKGALLFIDLDNFKTLNDTLGHAMGDMLLQQAAERLTSCM
REGDTVARIGGDEFVVMLEELSGAITEVVGEKILAALSQPYHLDNHTFRSSGSIGATLFSGDHQEAEELLKQADIAMYQAKKADRNTLRFFDHKMQDAIN
ARAELEAELHKALEHQQFELHYQIQVD-CASRALGAEALIRWNHPTRGLVAPAQFIPLAEETGLILPIGLWVIETACAQLHAWARDKTRHLVLAVNISAR
QFHQSDFVAQVRAAVQRNAIDPNLFKLELTESLLLDDTEKTVATMNALKATGVQLSLDDFGTGYSSLQYLKILPLNQIKIDRSFVRDIATDPNDAAIVQT
IIAMAGTLGLDVIAEGVETEAQLEFLDLRGCHACQGYLFGKPVSIREFESSLGQSS----
>tr|M2YFD0|M2YFD0_9PROT PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Magnetospirillum sp. SO-1 GN=H261_01926 PE=4 SV=1
-------------------------------------------------------------------------------------LFD-NAVDAVCAHRD
GVVVAANPAYARLFGYDVADDMAGH---PIITLAPEEHSRVGEII-RRAAGADVAPVTAKGLRRDGSRF-DLEIGASVFQ-MDGESYFIAVLRDVSEAED
SKRRLTESEELFMMSPDPTWIIQDN-RFVECNQAAVNILGYPDDSLK--N-------VHGSQAEAQMR--LAAKGEWRGELWNRRKDGEAYLEWLTISAV
AGPDGKPSRYVAVFSDVTELRRKDDQIRHQAYHDALTGLPNRFLLADRLDHALEVSRRVQTQVAVLFLDLDRFKVINDSLGHHEGDKLLVEVARRVGQTV
RRSDTVSRLGGDEFVVVLSSFSDTEVALVAEKIIAALARPLRLAGKAVHSGTSIGIAVFPQDGEDAATLLKNADTAMYQAKAGGRRCFRFFDRSMNEHAV
RRLELEAQLRQAIDSNQLELHYQPKVLVETGGLAGLEALLRWNHPEQGRIPPMEFIPLAEETGLIIPLSYWVIEEACRKLAKWRK-GGADVKVAINLSAR
QFHDEKLPQRIEAILQRNKVPGSALEIELTEGAVMDDPGRAIVILQRLRALGLRVSVDDFGTGYSSLAYLKRFPINAVKIDRSFVMDLPGDAEDAAIVRA
ILDLARALNLDVVAEGVETAEQLDFLAQAGCGQVQGYYFSPPRPAAELDAWISKAS----
>tr|Q47GC0|Q47GC0_DECAR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (strain RCB) GN=Daro_1362 PE=4 SV=1
-------------------------------------------------------------------------------------FFDATPDALLISDAH
GTITMANQQVEKLLGYVAAELVGKS---IEDLVPNRFKASHPVLRSASPRARRMGNGAVKARRKDGSEC-DVDV-SLSRIETDEGMFFASALRDISERKR
KEEELRRQNGIFQSFPGGITLFDADLRLVAFNDQFKALP----VLFE--Q-------PEGTQSEEQLR--IAATGAWQGEIWGRRKNGEVYPKWLSISAV
VGTNGRVSHYIGTHNDITERKKAEERINALAFFDQLTGLPNRTLLLDRLKQTILSSGRSDSHGALLFIDLDNFKTLNDTLGHDVGDQLLKQVALRLTHCV
RDGDTVARLGGDEFVVVLANLNTDKTETVAEKILATLNQTYQLGHVTHHSSASIGATLFKGPLIPIDDLMKQADLSMYKAKAAGRNAVRFFDPSMEIAVK
VRAEMEDDLLRALAEKQFLLHYQAQMV--GERLTGAEVLLRWQHPQRGMVSPAEFIPLAEETGLILPLGHWVLETACTQLAQWAGREVAHLTLAVNVSAH
QFRQNDFVDQVLGVLEKTGANPQRLKLELTESLLVENVEDIIDKMAALKHRGVGFSLDDFGTGYSSLSYLKRLPLDHLKIDQSFVRDVLTDSNDASIART
IVALANSLGLGVIAEGVETEAQRDFLASSGCHTYQGYYFSRPLPIEDFESFTLTAI----
>tr|M2Z9H0|M2Z9H0_9PROT PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Magnetospirillum sp. SO-1 GN=H261_05624 PE=4 SV=1
-------------------------------------------------------------------------------------ITESAQDAIITCDSD
GIIQNWNPAAHRMFGHERAEAIGQP---VTLIIPDRHVEAHNRGFKDHRCPKIIGTTEIVGRRKDGDEF-PLSL-SLSSWTLGPNEFFTAIIRDISEHKH
HQAMMAAVMAILENALVGIVLIRHRTI-ITCNRRFEEI---------------------GRQAETNQR--LAAEGMWKGEIWNRRKDGVIYPESLTLTQV
KEASGEVTHYIGIFRDISKRKAIEEQVNELAYFDPLTHLPNRRLLSDRLKQALAASSRTKRDGALLFVDLDDFKRVNDAHGHSNGDLLLQEVAKRLYANF
RCSDTVARIGGDEFVVLLADLSESEAKAVGEKILVTLGAPYQIAGSLFFSTASIGITLFGSQRDNIDELMKQADIAMYQSKAAGRNTLRFFAPELQARIK
ARATLEADLREGIKEDQILLYFQPQVD-GQGLLTGAEALARWHHPQRGLVSPGDFIPLAEETGLILSLGRRVLEFGCAQIAAWAGREMAHLTLAVNVSAK
QFHQVDFVEQVLAVVRGTGADPRKLKLELTESMLVENVDEIIAKMGRLKDLGFSFSLDDFGTGYSSLSYLKLLPLSQLKIDQSFVRDILTDPNDAAIAKT
IVALADSLGLNVIAEGVETVGQRDFLANSGCHAYQGYFFSHPLPLVGFEDFARRSK----
>tr|Q47ES6|Q47ES6_DECAR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (strain RCB) GN=Daro_1909 PE=4 SV=1
-------------------------------------------------------------------------------------LLDKLATPVFAKNLN
GLYIYANEMAGIMLGRPAPEILGRK---DSELFASELAGRMQTCDDA---SGESASCIWPDRGHGGERCYWLV-RKVLRDKKGQIVGLASVATDITDRKR
QELELIALKNTLQALPDLMFELDIEGQFLDCHAQQSK--GSPSMVGK--TV----HEVLGSNAEHALR--ESER-VYEGEVIEAEVEGGQTRIFNNVVAP
IKVDGQTIGIVGFNQDITDRKRNEEEIHRLAFYDSLTHLPNRRLMFDRLEHALIGSARRKSHGALLLIDLDNFKFLNDTHGHEVGDELLLEVAKRLKTCI
RQGDTAARLGGDEFVVILEDIDGGNAELIAGHIQAQLNHPFSLVSIDYRCASSIGIALFDDTMVTAKELLRRADTAMYQAKAAGRNTLRFFDPEMQAAVT
HRAALETELRKAIDEQQFHLCFQVQMD-QSGRPTGGEALLRWEHPTRGTIPPASFIPLAEETGLIVPIGQWVLATACRQLAAWSQQETSGLTLAVNVSAR
QFRQARFTDQLRDLLLQTGAPATRLKLELTESMMLEDTEAIIGRMAELKQLGIRFSLDDFGTGYSSLAYLKRLPLNQLKIDQSFVRDVLTDPNDAAIAET
IVALGNILGLEVIAEGVETDAQWRFLANVGCKNYQGYLFGRPLPLLEFEQFLQGCD----
>tr|D6XSU5|D6XSU5_BACIE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS
-------------------------------------------------------------------------------------AVD-ETTLISIVAPD
GRILYVNDRFCDVFGYTRDELVGSE---YGMIKS---NMHSQAFYDSTIRQGKSWSGIM-NAHKDGSKYWLQTAIYPVLNEDGSVKHYIAIRKDITEGKR
VEEQERLRIRVLNNLDNLVMRIETDGRYMLIGGNMLQLTGKV-----------------GT--EDALQ--LTA---FAGSGAGFELH-KNWHLYVNLAAI
SGEAGEVQAVTASVSDITALKQTEMAMRDMAFQDPLTGLPNRRRFELDVLNLIAERRGTDQGIGMLLVDLDQFKNINDSLGHATGDRFLVIAAERMKLDP
VDESELYHLGGDEFIYLISNYLP-TVQPFIRQIIRVFQHPFPYYDGEIHLQVSIGATFFPEYADSGEQMMKQVDMAMLAAKKFGGQSYRFFTDDMQKDFD
HYVLIERELRKALNGEEFELYYQPLYIAGESEPSTAEALIRWHHPERGLISPGEFIPVAEQAGLIVPLGQWILMQAAKDVKKWSRYTGHNRQISVNISSQ
QLQLPNFSSQLEEILLKEGVSPEQIQLEITENILMEKRKENVVKLVGLRKKGFTIAIDDFGTGYSSLSYLKSFPVDVLKVDQSFVKDLPNDEADKAIVQA
TIQMGINLGLHMIAEGVESAEAAAYLKKIGCHELQGYYFARPAPYDDFIRHTGKPL----
>tr|G2DFJ4|G2DFJ4_9GAMM Putative signaling protein OS=endosymbiont of Riftia pachyptila (vent Ph05) GN=Rifp1Sym_cs00070 PE=4 SV=1
-------------------------------------------------------------------------------------LVESTQDFVWETDSQ
GRYTYCSPQTKTILGYKPEELIGKT---PFDEVADQVSSQFAAIIQQ----RRPFSSENLNRHKQGHQVILDTSGMPFFDANGELAGYRGIDRDITQRKQ
AESYLRESERLIESLPNVAVQYDKELRVIYWNAASSRLYGYT-EEALGAQL----QDLI---------------PIPPGELELLHKDGHLLPVF-SSHVL
LNQDTDNPEMFCIDVDQSEQKRALDKLEHLATYDQLTHLPNRYLLESELSNRIKEAERFGQKLAILFIDLDNFKVINDSMGHEYGDILLLQVAKRLSSQL
RKYDTVARFGGDEFVLMMPMIQESEVAAVAKKIIREFATVFDLKEQEAFVTTSIGISLFPDDGQTTGELLQNADAAMYRAKDAGRNRYQFFTQTMNDELR
RYQQIETQLRRALETEVLQLYYQPQVDLRSGKIKSCEALLRWLPEDGEPISPAEFIPVAERSELIIRIGECVINAACRQRAAWKARGLRDFQIDINISGR
QFLFHDLYLVITKTLQKYGLSPTDIGIELTENVLIKADEKILSDLKRLHQAGMQIAIDDFGTGYSSLSYLKRFPVDNLKIDRAFVRDAPHDSDDRSIMEA
IVAVGHRLGMKVVVEGVENQAQHALSIEIGCDLAQGYYFHRPMPAEQLEALLEFPV----
>tr|Q21Q72|Q21Q72_RHOFT Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Rhodoferax ferrireducens (strain ATCC BAA
-------------------------------------------------------------------------------------TAVNACLVLSVTDCD
GVILFATDRFCELSGFDKDDLTGRR---HNIVSS---GTSSESFYRDTVLSGKRWTGIC-NRAKDGSLYWVDTTILPFTDTHGKITRFVAICNDVTNKKQ
AEQQLNQSRQWY-------WEQDTQFRFTLLSDGFKK-----DAAFL------------------------QT--------------TGL-PVWFSLSGR
GQFMGY-QGVGR---DISTRFSDQAQLWKLSNLDSLTGLPNRSRFETTLDRCVESGKASGEPFALVMIDIDNLKVVNDSMSFLAGDELLKIMARRLSCSV
RQTDFISRLSGDEFAVILLDLGTKDIHRLIETLRCTLEAPTDNAEQ-GRCTLSLGASLFPAHASASADLIKNANIALHRAKSNGGGQCVLFESEHKHRVD
RRATVLRAIEQAISVDRLMLYYQPVVNPVTRAVVSFEALLRWNHPKNGIISPGEFQEVFENRALTARIGKFVTDMAIKQAALWSRERVDFHKIAINVTTA
DFVLGGFPIWLADRLMHYGVDPAQICVEVTEGMFLGPAELVLSGLQIVHDMGAEIAFDDFGTGYASLMHLK-MPIDRLKIERTFVTNIENDKTNAAIIEA
IVQLGRRLGKGITVEGVETQAQADILLAIGCSQFQGYLYSKPLPAHQVASFIASYS----
>tr|A0A0C2BYZ6|A0A0C2BYZ6_9BACI Diguanylate cyclase/phosphodiesterase OS=Bacillaceae bacterium MTCC 8252 GN=QY95_2268 PE=4 SV=1
-------------------------------------------------------------------------------------YALDQSSIVAVTDQR
GRIIYANDRFCDISQYSREELIGKD---HRLLNS---GYHSSKFFKATIGSGKVWRGMR-NRAKDGSYYWVDTTIVPFLNKQGKPYRYVSIRNDITSRKQ
IAESLRKSEEIAERSSDLI--INKEGYFDYISPSHSSLLGHNLRLKA-NGL----------PLAEEI-------RSSLLEFRMCTARSEYRNIEATINPV
FDEEGTADRFVLVMRDRTEQKKSEEIIYHLAYHDSLTDLPNRRLFMKHVHEEVEKAKRLSLQAGVMFIDLDRFKYVNDLWGHESGDYLLAEAARRIKASI
RSTDLVARLGGDEFTVLLTNVNSEDVERTAQRIHLNFQEPVELPDQLYSLSCSIGIAVFPDHGKAADELLNRADTALYTVKEKKRNSYAVFHPEMEKKSL
ERILLENELRKAVEKEQFSIDYQPKWNFASGELIGIEALIRWRHPDLGTICPDKFISIAEEMGLMLPIEKWLLRHACIQGKEWQDKGYPSVKISVQLSSC
QLAHPGIEEQIGAILEETGLEPKWLELEVTENVLAD-VNEFSSVLEKLRLLGIHLSIVNFGSSYRAITHMKQLPIKTLKIDASFIENIHESKESRAIVQA
ALVLARTIGANVVAEGIEREEQLDILKAGGCVHGQGGLLSRPLSSEELETLWAHQG----
>tr|A0A059G8P1|A0A059G8P1_9RHOB Signaling protein OS=Hyphomonas oceanitis SCH89 GN=HOC_06288 PE=4 SV=1
-------------------------------------------------------------------------------------LTLDEFAIVARTDRA
GRILEVNDRFCEISKYERAELIGQT---HRLLNS---GFHPKSFFIKTISAGTTWRGIR-NRAKDGSFYWVLTTIVPETDAAGRVSGYTAIRVDITAQRN
AEDSLVLETRIIEAMPIGVGAYDQGDRLLLCNAAYRD-----GRDNW------------GR----SVA--SGA--------------LTD-GRWFQAQGR
KTAKGVSVEVVT---DISAIKQAESTIREQIKYDPVTEIYNRIGFDSEIETAISDYAKTGTAFALGLIDIDHFKRVNDRMGHAAGDAVLRGVARRLKGLP
GIRC-AARVGGDEFAVLIDMSGKIGGLKSAERGAAACFRPLSINGSMIDLSGSIGIAVFPDDGSDGETLTRAADMALLAAKRLGRSRVQLVNEEIKTQHT
RYGIILDTLPAAIENRQITPAFQPVVTAHTHMLKGMEVLARWEHPEIGAVSPTEFIPIAQEAGLLSALDQMMMESACELAGDWLTSGM-IKFLSLNASPT
ELATRGYATNLLATLRRVGIRPEQISMEILESAFIDDVPAVVRNLDRLHEAGVMIVLDDFGTGFSNLQAVMGLPLSGIKFDRSIIQRLDEEGMLSATINS
MVQLFQSFGMYTVAEGIETDAHLEMAEKMNVSCLQGYMFGEALSFAYADLFVRSNH----
>tr|H2CC87|H2CC87_9LEPT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptonema illini DSM 21528 GN=Lepil_0612 PE=4 SV=1
-------------------------------------------------------------------------------------VLDDTDDIVVITDSS
GSIQYVNRSFEKITGYAVEEVRGRT---PSILRS---RYHDSDYYSQTISIGQTYHGVI-NRKKDGTFYFEEKIITPIIDAEGQVTHFVSTGRDVTWRRK
AERLLRM---WSPD---------GL--LPVLHAIGRH-----CVEYWAK---------KGR----RRR--STF--------------RGLDGIILVYKAA
-ETLAALTDVGSQLGEYFRRRQAETMLTDMAYYDTLTGLPNRNLFYDRLRTALRHAQREQTSLAVLFIDLDRFKLINDTFGHRAGDELIHEAASRLRQAL
RPEDTVSRLGGDEFLILVENFENSDIQVVCQRIVQAFEAPFPVEEVEVFLQASIGVSCYPADAKDPPDLIRQADQAMYRAKQMEGSAFALFNYELDREVI
YSLEIQALLQTEIQNVNMQVHYQPQVDPLSRRVLGMEALLRWNHPERGWISPSRFIPSAEKAGMIQRLTEFVFERVSEDLR--AT-GSAIPEVSVNVSGK
LLHNPAFLEFIRERVEARKIDPSRIVLEITETAAVQFFEESCRKLQALKEMGFRIALDDFGTGHSSLNYLMQLPVDMIKIDRSFIGRIGENRKSREIVRL
ALDIASTLELETVAEGVETTEQMNFLIENGCRSVQGYLTGQPAPLGELVV----------
>tr|K0PZ64|K0PZ64_9RHIZ Putative Diguanylate cyclase OS=Rhizobium mesoamericanum STM3625 GN=BN77_3783 PE=4 SV=1
-------------------------------------------------------------------------------------TALDPHTIVGITNRT
GTITNVNDRFCQISKYSRLELIGAK---HSLLNS---GHHPPAFFQRVISGGARWHGIC-NRAKDGSLYWVDTTIAPKMDASGRICGYVSTRYDITQRKQ
AEKALNDENLIIETLPNGVAAYDENDRLILFNSGFKE-----RGGAI------------GR----AVA--SGE---------------SG-DRWIKVQER
RSASGYIVGVQT---DVTDLKRAERQVKLQAEADPLTGLLNRRTLIERLTAILS--QKAERHSALVLIDLDGFKAINDMHGHGAGDALLIEVGKRFRDNV
RKSDIVARLGGDEFAVLLVDVGSANAIRIVRKLLRSLENPVRLGRKAVRVSGSFGLTIVRKSKSTPLKVFKRADIALYQAKHNGRSTYAVYNTDMERSIR
RREAMIEALRRAIAQGEIQVAMQPQARFVDRGHAGFEALVRWQKDNQWV-PAAEIVSLAEQSDLICALGRAVLAGTLNAMCEMKRKGFAPGKVAVNVAAA
QLRNPNFAKELLDAVSAHGHSASEIIIEVTEGVILDRSEAIGVTLNRLFEAGVKIALDDFGTGYASLTHLQRYPVSYIKIDRSFVRDVGHDHGCHAIVGA
VTSLAHSLGMEVVAEGVETPSQYQSLLQTGCDYAQGYLVAKPILVEEIDTYLRNCE----
>tr|E8RCD6|E8RCD6_DESPD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfobulbus propionicus (strain ATCC 33891 / DSM 2032 / 1pr3)
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------RRHNLAVIRDITKRKQ
AEEELVFAAKVFDNSIEGIVVTDADATILQVNPAFTVITGYGPAEAIGQNPRMLKSDKHLPAFYQAMWNQLAREGQWAGELWNRRKNGEVYPEWLTISAI
RNPLGRVTHYIGLFHDITELKRQQEALEHQAQHDALTNLPNRVLLNDRLAMALARMKRKSVKAALLFLDLDHFKNINDGFGHVAGDNLLVELSRRLKEQL
RIGDTLARQGGDEFLILLPEVDSDDVGLVALRLLNSLRQPFHHQDIEYFIGASIGVTIAPDDGTDADTLIKNADMAMYRAKQLGRNNYQFFTPELDAQAH
RRISLESKLRRGIEQGELELHFQPVVSSGSGKIHGAEALVRWRHEG-ELIAPGEFIPLAEESGLILPLGEWVLRTAAGRARAWQDAGY-RLGLSINLSSR
QFTDQELVKLYLAVLADTGLEPGRLYFEITESLLMKEIDRAQHILGALRDIGGKFYLDDFGTGYSSLAYLKRLPLDGLKIDRSFIRDIESDADSRAIVEA
IVSLAQTLHLAIVAEGVETTEQLGFLQGMGPMLIQGYLASPPVPAERFDALLRQGDS---
>tr|C7LTY3|C7LTY3_DESBD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfomicrobium baculatum (strain DSM 4028 / VKM B-1378) GN=Db
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------PESYLAVVRDITVAKK
AEEKLLLAAKVFENTVEGIVVTNTEGTIEQVNPGFTVITGYSADEAVGSNPRILKSDRHAQHFYQEMWTKLTQDGHWAGEIWNRRKDGESYPEWLTISAV
KNEAGQTTNYVSIFHDITELKRQQDALEYQAQHDALTGMPNRILLGDRLRMALAQLARSGGKLALLFFDLDNFKTINDGLGHGVGDELLVDLSRRLERLL
RSGDTLARLGGDEFLILLPEIESDAASHIATRMLDALKAPFHHGDVEYFVTASIGLTIAPDDGNEAPKLIKNADMAMYRAKSMGRNNYQYFTPEMDVAAH
RRISMEYKLRKAIEAQEFELFYQPLVHIQSGHILGAEALIRWRCEG-KLISPAEFIPLAEESALILPLGDWVLRTAAHQAKLWQDAGH-DLTMSVNISSR
QFSGADLAVTLREVLLDTELRPGRLYFEITESMLMGDVSKAETTLLNLREAGGTFFLDDFGTGYSSLSYLKRLPIDGLKIDRSFIKDITDDSDSRAIVAA
IVSMARTLNLRIVAEGVETQAQRGLLASMGPIVLQGYLASRPVPAQDFEALLSRDA----
>tr|A0A0C3RLM2|A0A0C3RLM2_9PROT Contig_10, whole genome shotgun sequence OS=Nitrosospira sp. NpAV GN=SQ11_07630 PE=4 SV=1
-----------------------------------LWTLVFWVSMAILLAIAAVSGAVWLLWRQQ-RRAHQLALLVRTAEKLLKYFYEL-PGMAITSPDS
KRWLRFNDRLCEILGYSREELAVKN--WM-EMTHPDDIKK-DIVEFEKVMHGEGYTMNKRYIRKDGSVVIANMSVKCVRTDDGKVNYFVAMIRDITEQER
RKTEALAAQATLDAIPDDILPSAAVD-IIVSALLEAQEKGL----SAGKQLELEFA---------------------QGKLWF----------ELSVSRK
HVDPGHEPRFIVLARDVTERKASEQRILNLAHYDSLTGLPNRALLADRMRVAIKRAERQSTRLAVLFVDLDRFKPINDSLGHDIGDQLLKAAAQRMQTSV
RSVDTVSRVGGDEFVVLLSEIETEDAARVADKLIMGLSQPYGIEGHELQVTASVGICIYPDNGTQPNVLLRNADASMYSAKESGRNRYQFYSDDMTVQAM
ERLSLERDLRGAAQRGEIYMVYQPQIDLATKRIIGAEVLMRWRHPTQGLIAPARFIPIAEDSGLILVIGEWILSEACRQARQWRDRGILDACVSVNVSAV
QVRQSDFVRVVERAINESGLPPNCLELEVTESVVMQGIDTTVQKLRELDALGVKVAIDDFGTGHSSLAYLRQFTVDRLKIDQSFVRDLPGNIDAEAIATA
IVAMGLSLGLRIIAEGVETEAQAKFLQSVLCKEGQGYLYARPMEAGDFEAWVTAW-----
>tr|M5DPG2|M5DPG2_9PROT Sensory box/GGDEF family protein OS=Nitrosospira sp. APG3 GN=EBAPG3_3500 PE=4 SV=1
-----------------------------------LWTLVYWVGIIILLAIAAVSGAVWLLWRQQ-RRAHQLALLVHTAEKLLKYFYEL-PGMAIISPDS
KRWLRFNDRLCEILGYSREELAVKN--WV-EMTHPEDIEK-DLIEFEKVKRGEGYTRNKRYIREDGSIVLANINVKCVRRNDGKVDYFVAMFRDITEQER
RKSEALAVQATLDAIPDDILPSSAVD-IIVSALLEAREKGL----SSGKQLELEFA---------------------QGKLWF----------ELSVSRK
HVDPGHDPRFIVLARDITERKASERRILNLAHYDSLTGLPNRALLADRMRVAIKHAERQSTRLAVLFVDLDRFKPINDSLGHDIGDQLLKAAAQRMQTSV
RSVDTVSRVGGDEFVVLLSQIGAEDAARVADKLITGLSQPYGVEGHELQVTASVGICIYPDNGTQPNVLLRNADASMYSAKEAGRNRYQFYSDDMTARAI
ERLSLEHDLRGAAQRGEIFMVYQPQIELATNRIIGAEVLMRWRHPTQGLIAPARFIPIAEDSGLILVIGEWILVDACRQAQQWRDRGLLDASISVNVSAI
QFRQNDFVRVVQRAINVSGISPDHLELELTESVVMQGIHSTEQKLQELEALGVKVAIDDFGTGYSSLSYLRQFTVDRLKIDQSFVRDLPGNIDAEAIAAA
IVAMGLSLGLRIIAEGVETEAQAEFLQRILCKEGQGYLYARPMEAKEFEAWVAAW-----
>tr|Q2Y8B4|Q2Y8B4_NITMU Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Nitrosospira multiformis (strain ATCC 251
-----------------------------------LWTLVFWMSAVILIAVTAVSVVLLLLWRQQ-QRAHQLALIIHTADRLLKYFYDL-PGMAITSPDT
KRWLRFNNQFCEMMGYSTEELAKKS--WI-EITHPDDVAK-STAERERILKGEGYAMNKRFIRKDGSIIFANVDVKCVRRDDGTVHYFVAMIRDITEQER
RKTEILAARATLDAIPDDFLPTGAVD-IILSALAEAQEKGL----SSGKQLELRLPG-------------------REDKWWF----------ELSVSRK
HVDSAAGLRFIVLARDITERKASEQRILHLAHYDSLTGLPNRALLADRMRVAINRAARQAKRLAVLFVDLDRFKAINDSLGHDVGDHLLKVVAERMQTSI
RSVDTVSRVGGDEFVVLLNEIETEDAARVAQKIIDGLSQPYQIEKHELLLTGSIGICIYPDNGKEPNILLRNADASMYTAKEAGHNRYQFYSEDMTARAI
ERLSLEHDLRGAVERGEMFLVYQPQIELGTSRVIGVEVLMRWRHPARGLISPVRFIPVAEDTGLILSIGEWGLRESCRQAQLWYERGLLNACISVNVSAV
QFRQTDFVGIIENALQESGLAPTNLELELTESAVMQGAEPALNKLRELDALGVKVAIDDFGTGYSSLAYLRQFTVDRLKIDQSFVRDVPGNNDAEAIAAA
IVAMGLNLGFRIIAEGVETEAQAEFLQSVLCKEGQGYLFAWPMTAIEFEAWIAGW-----
>tr|A0A063Y421|A0A063Y421_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Nitrincola lacisaponensis GN=ADINL_1021 P
-----------------------------------VYMMAAWLALLSLATVISIMFALRLVWQQN-RRLQQAAFQVQAAEKLLLKFFEM-PGMAITDPES
GRWLRFNPELCRLLGYPEEELKTLT--WQ-AVTHPDSLEA-DQQAFQRLQEGDSYTLEKQFVRKSGSVFTALLNVGAVRFAGGQLQYCIATLQDISDQKR
YESDILHQRTLS-----GWPVTYV--------SANVSRWGYSAHNFLSEEVALYLSQRREEYLQ-----EYRVLTREGQELWVEDHTKVIYGL-------
---TGEVEVIEGVVTDVTSRKTIQQRIEFLARHDSLTGLPNRLDVL------TSIETRGNPQTALLMLDLDRFKDVNDSFGHRTGDQLLCRVAELLRKEC
PADGLLARFGGDEFGVLIDRDQ-DALMELAEALIEALRTPIQLPGMEIRIGACVGVARFSDAEQSAEELMRQADAALYKAKEAGREQLRFYTNELTRAAL
IRLDTEARLRQAMSDRQLSVYFQPQIDIETGQLLGAEALLRWQDPQLGFVSPASFIPVAEQSGLIHVIGEWVMDQVCMTGRRWLDQGYPPLRLAVNLSSF
QLRHGDIVGMIRQTLEKHDYPASGLEVELTESALMRREDEAEKVFEALQAMGVSLAIDDFGTGYSSLAYLKTFPLDVLKIDKSFIEDLEVSADDREIAAA
VIVMGHTLGLKVLAEGVETEAQLALLRELGCDYYQGYLKSPAVSADAFEQFFRN------
>tr|F9UD49|F9UD49_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_2852 PE=4 SV=1
-----------------------------------LKVLVFWVSLIAFFAIVVAGILSFSFWRLQ-QRAHRLEMKAQAAERLLTKFYEL-PGMAITSPLT
KQWVHFNDRLCEILGYGRAELAEKT--WS-ELTHPGDLD-ADLDEFGR--AGDGYAMEKRFVRKDGQVVQAAIDVR------------------------
-----------------GVMVMDCDRRIVQVNGAFVALTGYSEGEAVGRTSELLSPEVHDAAFFESLWSTIGETGHWQGELWNQRKNGELYPVLLNISAV
KDVSGKVIQFVGAFSDLSQIKESESRLDFLVHHDPLTRLPNRLLLVSRLDHAIAVAIREDQHLALLLLDLDRFKDVNDSFGHPAGDVLLKQTALRLAGCL
DPADTLARLGGDEFAILLEDLPDQAAARAAERLIAAVGESAVLPGVEVRIGASIGISLCEGPGLNAGEMLRQADAALYRAKAGGRSRFDFYTEDLTHSAR
QRVETERRLRDALAEGQLVAHYQPQVEIATGRIIGVEALVRWNDPERGLIPPGEFIPLAEETGLIGPLGEWVLHEACRQGALWMEAGIAPLVIAVNLSAY
QLRQTDIVESVARVLRQTGFPADRLELELTESALMEREGDTLGVLERLRAQGIRMAVDDFGTGYSSFAYLRRFRLDLLKIDKRFIDEIDQQPDARTIVDA
IIAMGHALGLQVLAEGVETRSQLDILRDQGCDLFQGYLKSRPLDPDAITALLRTD-----
>tr|C4L9X9|C4L9X9_TOLAT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Tolumonas auensis (strain DSM 9187 / TA4) GN=Tola_0479 PE=4 SV=
-----------------------------------LHNLVYWITLVVFFAGLLVIFVVSLLWRQQ-QYTNQLELQRQTSERLLKHFFEL-PGMAITHGQT
GHWIRFNHQLSDLLGYSHSEMAEHT--LL-SLTANEYQE-ADIAAMYQ--QDDGYLCEKQLRRKDGQLIYVNVDTR------------------------
-----------------GIMITDKNAQIIRVNPAFAELFGFSQHELQGKTPVIFKSGKHTHEFYQHIRDSLNTSAFWRGEIWNRRKDNHIIPLICSISAV
RNDKQQLTHYVSVYSDISKLKASEAKLAHLAHHDPLTQLPNRTLLTINLSHAIDLAVRNHHRIALLMLDLDRFKDVNDSFGHQIGDALLQEVARRLRRRV
RISDTICRLGGDEFTVLIEGNPAHDVEHFAEDILQLLKDPFSLPGREVIIGASIGISLYPEHGQTPKELLQQADAAMYRAKAHGRSCFRYFSDELTRAAE
QRLDLEVRLQRALRLNELCLYFQPQIDISSNRIIGAEALVRWQDPAHGLISPAQFIPVAEETGLIKQLGEWVLLEACRQGKEWQQKGLPAINLAVNISPV
QFRNSNILESVFNALKQTGYPASLLELELTESALMTHENEAVEILSALRKYGIRLAIDDFGTGYSSLAYLKRFPLDVLKIDKSFVDDIPHKKDDMEIAAA
IVAMAHTLRLKVLAEGVETEEQLTFLKEQGCDCYQGYLMSPPVPADQFEQLLRAQ-----
>tr|F7NVY0|F7NVY0_9GAMM Diguanylate cyclase (GGDEF) domain-containing protein OS=Rheinheimera sp. A13L GN=Rhein_1940 PE=4 SV=1
-----------------------------------LETLLLWLSIISGTFLMLLVLGALFYWREL-IQSHELALAAKQTEKTVQAFFEL-PGMAILSRTH
LPFIRVNKKLQSVLGYAETELLALS--LR-DLTQSPEQFMALLATFEDLHRIDGISCEYRFFDASGTIRYIRDDLRLLPAQTYDHQQIIGAMVDITELKQ
ARFEQDASNTLFNTMSEGIMVTDASNRIIQVNQSLLQMLGYEEAEVLGNSPAMFASGRHDQSFYTKMWQQLSKHGHWQGEVWNRRKNGEIYPELLSISTI
VDASQQVTHYVAVFADITQLKASEQELAYLAHHDVLTDLPNRLLMSSRLQNAVDLAKRDQHQFAVLMMDLDRFKYINDSFGHPSGDELLKLVATSLKQRL
RDIDTVARFGGDEFIILLEQLHQEDAARFATQLINDMSQPWILSNVEVRIGASIGISIYPDHGSEGETLLSNADAALYRAKEQGRGRFAYYSDDLTLYAR
QRIELEARLRAALQLEQFLVYYQPQTDIKTGLIVGAEALVRWNDPVEGLIPPGRFIPIAEDTGLIGAIGDWVLAETCRQGAAWRAAGLPDLKLAVNLSSH
QFSHGDIGEQTAQILKDTGFPAELLELELTESAIMSREQQAEQVLSDLHQMGVKLAIDDFGTGYSSFAYLQRYQLDVLKIDKSFIDDVADNSESQAIVTA
IISMAHILGLKALAEGVEQQEQLDYLRQQGCDYYQGYLCSKPLPAKDFEQLVRSQ-----
>tr|D3SBF6|D3SBF6_THISK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thioalkalivibrio sp. (strain K90mix) GN=TK90_1870 PE=4 SV=1
-----------------------------------PRQQALWMGAATLFVWLIMLAAGGLLWRQQ-WLRQHLVLMHSHAERLLRLYFDM-PGMAISYPGG
RGWERVNPFLAQMLGYSPEELVRTD--WD-RLAVPEDRSCE-------MQAGDGYSIEKRLLRRDGRVLVADIDVK------------------------
-----------------GVVITDATAHILSVNRAFTELMGYTQDEVVGRTPKMFQSGRHDQAFYANMRRQLETEGHWQGEIWNRRKTGEIFPELQSITAV
RDDQGRLTHYVSVFADISRLKASEAELDFLAHHDPLTELPNRRLLRARLAQAIALMRRRNGLLAILIIDVDRFKDINDSRGHAAGDRLLKIVADRLQAGQ
RGTDTVARLASDEFAVLADNLAHDDAALVAEDILREVGRPVDLGGVEFEIAATIGIAVFPDHGADAETLLQQAGTALSRAKEDGRGGYRYYSDAFTEAAR
ERIDLNARLRRAIEQDSLEVHYQPQYRVSDGVLIGAEALLRWTDPELGPVSPGRFIPVAEQTGLIVELGDWVLRRVLAQGQAWRDAGYPAVRLAVNVSAL
QFQRVAIDHQVADLLEGHGYPAKYLELEITESALMSDPERARRILQRLRERGVSFAVDDFGTGYSSMAQLKRFPVDTLKVDKSFVDGLAHDADDRSIARA
IVALGHGLGLSVLAEGVETREQLGALRELGCDHYQGYLASRPLPAEHFAALLAEG-----
>tr|S9ZM52|S9ZM52_9RHOO Uncharacterized protein OS=Thauera terpenica 58Eu GN=M622_14930 PE=4 SV=1
-----------------------------------IRRIAWLVSVVTLLFIGGAGAATTIWWRNQ-RSSLLADVYRA-RWQASQRLENITYDIILLLDEH
HHIVEANERAVEAYGYALAELRGMH--TI-ELRDATA--------------------DRNYWTTAGKAFAVEVSGRVVALD--GQRYHLAIIRDISERKR
A----------------GIMICDSKNRIVAINSGFTRLTGYCIDDLQGKNPSVLASGETPRDTYRELWSSIKRDDYWQGEVLNRRKDGTLLPEWLNISVV
RNDKGKLSHFIAAFTDISERKAAESEIRHLAHHDVLTGLLNRYSLQSRLEQALSTVRREQQMLAVLLLDLDQFKSINDTLGHAMGDKLLKLVAQRLHDSV
RDSDIVSRLGGDEFVIVLTDLGGSAALRVADKIRRALAQPYFIDTEVLHITPSIGLAVYPSDGGDCETLVKNADVAMYHAKAQGRNNIQFFNPQMNQAAM
ERSRMSQALRVALDEGQFELHYQAQLDTRSRAVVGFEALIRWRHPVEGLISPQEFIPVAEDTSLILPLGEWVLDEACRQLREWQDAGMNGVTMAINLSAH
QLRSPKLVSHVAATLEKHRLQGADIELEITESVAMHNPEASIKQLQALRNLGLRLSIDDFGTGYSSLSYLKLLPIQTLKLDRSFVRDIETDVNNVIICTT
TIALAHSLGLKVVGEGVETTAQHNLLKAHGCDLVQGFLFSKPLTAALVPGFVDEN-----
>tr|Q1K210|Q1K210_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_2724 PE=4 SV=1
-----------------------------------LFRIATIEAVTAIMFLAAASIMMMLWWRRQ-QALYQASYYQQQLQQMLQRFDNLTFDLVLLVDAQ
GQIIDANERALDTYGYPEDELKTFK--LK-DLCDLSQQECD-------------------LKVEQG----------------------------------
---------------------------------------------------------------------------------MQFRQDGSTFPVEINARWI
DLDRGH--LVQAIIRDISERKAAEDQLVHQAYHDPLTGLPNRLLISDRLKLAIAKARRHKTQAVLLLLDLDRFKNINDTLGHAVGDRILTTLAQRMQETL
RDTDTVARFGGDEFLVLLEDIRESDVVSLAQKLSDLVSQPVLIDGEEMCLTTSVGISVAPEDSIEVDQLIRFADTAMYRAKEKGRNNFQFYTPDMNAHAG
RRLQLENNLRKALQRQEMVVYYQPQVEMDSGRIIGSEALLRWMHPEHGLISPNDFIPLAEETGVIEEIGAWALEQACQQTVAWQK-NHPELKIAVNLSAR
QFRNENLVDDIEQILNKTGLAARHLEMELTESLLMEDVDVAIDLMNRLTKLGITLAIDDFGTGYSSLSHLNRFPIDKLKIDRSFVNSMS--LDNNGIART
IITLGRTLGLSIIAEGVENNEQRQLLLQLGCPQAQGYYFSRPVHDNAFSEMLEKP-----
>tr|J1EKA2|J1EKA2_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_02621 PE=4 SV=1
-----------------------------------VQDRSRLLVL-GATVLILLGSLLYAAWRRG-DHHRH-------AAAGLRHYEHVMGDIFFLTDND
GTILDVSQATVDVYGYPREQLIGMN--AQ-RLRPPDNAAAQ------AMQPGRHV--RIPRLRADGSTFLLEGTVGCFES--DGQRYFVGIGRD------
-----------------AIVVGDRDKRIVSINAHLTKITGYTLEDLQGQPTVILNAGLDPAGVERA-RAILQTEDFWEGEVHIRRKDGTVFPARLLVCAH
RGADGQVEQHVDLFTDLTRLKQAESQAQYLAIHDPVTGLPNRARLEQELSQYIASAVSPHNSLSLALVNLDRFKGVNESFGYAQGDVLLVETARRLQGLS
ADLKGLYRYGGDEFMLVLAGNPV--HALLISQVRALLAPPIRLPEHPVSPTASIGIASYPEHAHTAEDLLHNVEAAMRIAKAHGRNTWRLYAPEMNASAY
DDMLLAVDLRQAIDVGELELHLQPQFTLAHGQPVGMEALLRWTHKTRGPVSPARFIPIAESSGMIAEIGNWVLREAARIWSRWRSEGLVPLPIAVNLSAV
QFQAPDFLHEVGRVLSEFDLPAGALEMELTEGTLMANTDAAVETLHQLVGKGIQIAIDDFGTGYSSLSYLRRFPVSKLKIDRSFILDLGGNEEAEAIASA
VIAMAKSLKLRVIAEGVETAEQRDFLKDHGCDELQGYLYARPMSVEAATALLAAT-----
>tr|U1K169|U1K169_PSEO7 Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudoalteromonas piscici
---------------------------------------------------------------------------------KWGHAIEQSPSSIVITDPR
ARIEYVNPKFEQVTGYSLEDVKGQTPKVGSKQ-GFTDYK----TLWQTIKQGKVWRGEFYNRRKSGDYYWEYASISPIKNQQGEIINFIAIKEDITAQKS
ASAQLKTAAAVFNATQEGIMTTNAKLEITAVNPAFTKITGYEEHEVLGQRPNILSSGKHDKHFYEQMWSTLNSHGQWASEIWNKRKDGTLYPEWLAISVV
HDDKGLVQQYVAILSDMTERKAQEEQIEYQAYYDVLTGLPNRTLLLERIEQDIKRMSRTHHQSAVLFIDLDRFKRVNDTMGHEAGDALLISVAKRLNGLL
RKSDTLSRFGGDEFVLLLSQIAHDHAAQVADKIVKALSEPFVINGFEVFTGASIGIAILPSDAKDQKELLRLADLAMYKAKEAGRNQYHFFAQEMQQQVN
RRVELEQLLRAALEHQRLTVHYQPIVDTVSGKLYGVEALMRWPTDFGQYISPAEFIPVAEESGLIAPLGEWLLAKACNDIRRLNKALGMNCYLTVNVSSQ
QYRLGFNATTIKQIMQQSGFLPENLTLEITESILLEDDKAVTAWLQSLRATGVNLAIDDFGTGYSSLSYLKRFPINILKIDRGFIQDIDQNQDAAVLVNA
ILSMAESLSLKVIAEGVEQQGQLDCLKDLGCQYVQGYFYAKPMAIEGLIDWVEQF-----
>tr|G2DF26|G2DF26_9GAMM Putative signaling protein OS=endosymbiont of Riftia pachyptila (vent Ph05) GN=Rifp1Sym_cj00230 PE=4 SV=1
---------------------------------------------------------------------------------KLSRALEQSPASVLITDTE
GTIEYVNPKFEQISGYSSEEAIGKNPRIKSGDKSREDYK----ELWETIKAGREWRGAFHNKRKDGTIYWESASISPLRNEGGEITHFIAVKEDITAQKR
AEEQLRMNATVFETTTEGIMVTDADNRIKTVNPAFTRITGYQAEEVIGRNPRLLSSGRHDQAFYKAMWVSVKQQGSWSGEVWNRRKDGSIYPEWLSVAAI
RTEHGTVSEYIAVFSDITQRKESEQQIRFQANYDALTGLPNRSLLLDRLTHAINSAEREAWELALLFVDLDQFKIVNDTFGHVMGDELLQHAAERLKSCV
RESDTVARFGGDEFIILLQDISGDDAAQIADKVIEKLSRYFLLAGREVIIGASIGITLFPDDASDSDTLLRNADMAMYRAKETGRNRYQFFTTAMQEQVS
IRQHLEQDLRGAPERNELELHYQPVVSATDGRLVSMEALLRWHHPDQGLIPPDQFIPLAEETGLIGPIGVWVMSTACRQAALWQAQQP-GLKIAVNISSR
QRELGLSAKLLELILQETGLDSSLLTLEMTESLLMEDTEEAVTWLESFKALGVALAIDDFGTGYSSLSYLKRFPVDVLKIDRAFVSDLPDDQEDASLVEA
IVAIAQSLELKLIAEGVETAEQAKFLDDIGCDYLQGYHFSKPKPASEFTEQLAGE-----
>tr|A0A063YAG1|A0A063YAG1_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Nitrincola lacisaponensis GN=ADINL_0188 P
---------------------------------------------------------------------------------QLGRALEQSPSAVMITDTQ
GIIEYINPKLSEMTGYDSKELLGQNNSIKSGEMPAGLFA----EMWQQLRDGQTWSGQLLNRKKDGSLFWDSTSISPLRDDSGVISHFIAVKEDITERLR
AEEQLRMVAAVFETSNEAIMIADQQGRIKVVNAAFERITGYAAHEVQGHNPSLLSSGRHDRIFYEQMWDSLIRQGNWSGEIWNRRKDGSVYPEWLSISAL
HDEEGQITEFVSVFSDITSRKEAEAHIRHQAYYDALTQLPNRSLLLDRLAVAIHTAERDQQTLSVLFIDLDRFKYVNDTLGHEYGDELLVQVARRLGNCV
RESDTVARFGGDEFVILLHNIHSRDAALVAEKIIRRLSDPFTLAGREIVIGASIGLAMFPGESDDPDTLLRNADLAMYRAKQTGRNRFQFFTNSLQEHAN
NLMEMEQDLRLALEQNQLEIYYQPLVRAQSGRVTGVEALLRWHHPTQGMIPPDQFIPLAEDTGLIGPIGQWILETACRQVSQWHQQGL-KFYLSVNISGR
QRDLGLDAELLSSILERTELAAGQLVLEITEGMLLDNSDETIAWLQSFCDLGIHLAIDDFGTGYSSLSYLKRFPIDTLKIDREFIRELTLDNEDALLVEA
IISMARSLKLRLIAEGVETAEQRSALFRLGCEYLQGYHFSRPLPADQLVNWIQAY-----
>tr|W9USU8|W9USU8_9GAMM Cyclic di-GMP phosphodiesterase Gmr OS=Nitrincola sp. AK23 GN=gmr_16 PE=4 SV=1
---------------------------------------------------------------------------------MLGRALEQSPVAVMITDRK
GIIEYVNAQLAEMTGYSESELLGKNNNIKSGEMSSQVFT----DMWKELNRGNTWSGHLLNRKKDGCFFWDSTSISPLRTEEGDISHFIAVKEDITERLV
LEEQLKMVAVVFETTNEAIMIADQNGRIKTVNPAFTKITGFTKEEVIGKNPSILSSGRHDRNFYHQLWSTLSVEGAWAGEIWNRRKDGSVYPEWLSISVI
RNDSGDISEYISVFSDITSRKNAEARIRHQAYYDALTELPNRTLLMDRLEMSIVSANRDQQTLALLFVDLDRFKYVNDTLGHEYGDELLINVARRLLSCV
RESDTVARFGGDEFVVLLHNICSKEAGRIAEKMIQQLSYPFMLAGREIIIGASIGIAMYPSVSGGADNLLRNADLAMYSAKQGGRNRYQFFSEQLQEDAN
SMMEMEQDLRVALEQKQLEVYYQPIIDSRTLSLVGVEALLRWNHPLHGMISPDRFIPLAEDTGMIGVIGQWVLETACRQAGQWVAQGY-HLYMSVNLSGR
QRSLGLDDIVLRNILESTGFRPESLVLEITEGMLLDNSHATIEWLSSFSRMGVQLAIDDFGTGYSALSYLKRFPIDILKIDREFIRELGHGTQDMLVVKA
IISMAKSLKLRIVAEGVETDDQLAILQDLQCEFVQGYLFSKSLTAYELEVSFDTL-----
>tr|A0A069NMW2|A0A069NMW2_9BURK Diguanylate phosphodiesterase OS=Burkholderia grimmiae GN=BG57_26535 PE=4 SV=1
-------------------------------------------------------------------ARNAARITARQAHDRFIEYFEQHPLAMLIYDIQ
RLILTANAAAQRQYGGDLGTLRRIT---VDELRPLDGIEPFRQDLLTYIGSKAGSAGVRRHSTLDGRTLHVDVSYHFL--EYAGHSACFITAADVSEHET
ARAELRIRSRALDASQNAVLITESGPRVVYTNPAFERLTGLAANEVLGERAKVVLSAAFSGEHATPINRNSDGINDGSTVVSGKRADGTLFWAQRQVSPV
IDERGVATHAVTVFSDISERIRDQQRLSWLASSDPLTQLPNRAALHARLGELIATASSRGHRVAAVFIDLDNFKEINDSLGHTAGDCVLKEVAGRLSREV
REPDVVGRIAGDEFVALLSGS-DDRLIDEARRLHRSANAAFPVGEGIVESRASVGMAVFPDHTTNAEELIRCADAAMYHAKRERDGAMRIFDRSLAVANA
ERLHLTQQLQHALKCDDFRLAYQPRITVSGSRTVAFEALLRWTDATRGDVSPATFIPLAEEKGLIVPIGEWVLRNACLQARKWAD-DYPDIVVSINVSPL
QFLRSDFAKTLERTMHSVGVNPRNVELEVTESVLMT--PVALACLHQIRRLGVSIAIDDFGTGFSSLTYIRDFKADCIKLDMSFVHGIGVSTIDEVIVRA
VLAMAHTLGMRVVAEGVETPEQLAFLADHRCDQIQGFYLGKPMPASDASATLARSNNG--
>tr|D5WMX7|D5WMX7_BURSC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. (strain CCGE1002) GN=BC1002_6741 PE=4 SV=1
-------------------------------------------------------------------ARQSARVIASESERRFRQYFDHHPLPMLIFDVE
LSILAANRAAASQYGRTRHQLCSLD---MAALYAQADLPSFLRDLHALLATTSGSAGVCRHRHSDGTPVYVELSYHFL--TYGHHRACFITAVDVTERKN
AELALLLRSRALDAIGNGVIITRP-DVVEYANPAFEKITGYERPQNAGGDHSARP----ETPGLQQIGTAIAGQREATTLTKSRRANGTEFWYQLYVAQV
RDESEKVTHHISVVSDLTELIESRDLLVRQARRDALTDLPNRVTLRELIDA----AILDGHEFALLFIDLDHFKDINDSLGHGAGDRLLQEVARRLSASV
GSDGVVTRYGGDEFVTMLKCSTGAELSALLARVTQTLDEPVQIDDMQLRVRMSVGVSCYPQDGTDCETLLKHADLAMYRVKAGGRNGVERFAPSLAHEAA
QRIALSHKLRNAVEHNGFELVYQPQVDIRSYRLTGVEALIRWHDADFGTVSPTTFIPLAEDIGLISSIGEWVLQTACAQAKRWEE-ALPELRMSVNVSPS
QLTSSDFGAVVRRALAASQLAADRLELEITEGGLVA--PGALPTLSALHDIGVSIAIDDFGAGYSSLAYLRSFHADRLKIDMSFIRGIGSSRADETIIGA
IIALARNLRFEVVAEGVERAEQLAFLAEAGCEIVQGYYFAAPQPAANIPGYAASLIGE--
>tr|K0DXH2|K0DXH2_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Burkholderia phenoliruptrix BR3459a GN=BUPH_00602 PE=4 SV=1
-------------------------------------------------------------------ERQRVHLVAAENARRFQQYFDHHPLPMLIFDVD
LAIITANLSAASQYGCTRDELGARD---MASLYSQEDMPAFLRDLRCLRGTGSGSAGLCRQRRNDGRSIYVELSYHFL--TYAKRDACFITAIDVTERKN
AELALRLRSRALDAIGNGVLITRA-EVFEYANPAFEQITGYANAQIVGRDQVSLSR-ASQHGILEQIREALADKRDGARLVRSRRADGSAFWGQFYVAPV
RDE---LTYHICVVSDLTELVDSRDRLVRQARRDALTELPNRVALRELIKE----AIATRREFALLFMDLDHFKDINDSLGHAAGDRLLREVARRLLAAI
GNDGTATRYGGDEFVSMLDSPQEGRLSALLGRIGQAFEHPVQIDDVQLRVQLSTGIACYPADGLDADTLLKHADLAMYDAKAHGRNRVERFKPSLANAAD
RRIALSHRLRAALDQNAFELVYQPQVDVRTYRISGVEALLRWNDAEVGTIGPATFIPLAEDIGLIEQLGEWVLHTACAQAKRWEE-AQIPLRMSVNVSPR
QLVVGDFCAVVQRTLAASRLAASRLELEITEGAMVA--SGALPALRRLNEIGVSIAIDDFGTGYSSLSYLRAFHADRLKIDMSFVRGIGASREDEAIIRA
IIALAHSIGFEVVAEGVERADQLAFLADDGCAFVQGYYFCRPLAAAEIPHFVTQFARK--
>tr|A4JQX8|A4JQX8_BURVG Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Burkholderia vietnamiensis (strain G4 / LMG 22486) GN=B
-------------------------------------------------------------------ERQRGRLVAAENERRFRQYFEHHPLPMLIFDVE
LAIMAANVAAAAQYGYPVGELCRRD---MASLYAQADMPAFLRDLQHLRGTGSGSAGICRHRRSDGRAMYVDLSYHFL--TYTKRDACFITAIDVTERKN
AELALRLRSRALDAIGNGVLITRV-EIVEYANPAFETITGYTSAQVVGRDHAGLAR-AGQQGLLEQMAQALAAGSAGARLLRSRRADGSAFWGQLYVAPV
RDD---LTYHICVISDLTELIDSRDQLVRQARRDALTGLPNRATLRELIEQ----AVAERRAFALLFMDVDRLKDINDSLGHGAGDRLLREVAQRLSGCV
GEDGTVTRYGGDEFVAMLGRPDDDRLAALLRRIARALERPVQIGDAQSRVQLSIGVACYPADGLDAETLLKHADLAMYQAKARGRNTVELFKPSFAEAAE
RRIALSHRLRAALEHDGFELAYQPQIDVRTSRVSGVEALLRWHDAEMGTVSPAIFIPLAEDIGLIGQLGEWVLRSVCGQAKRWAD-TLPALRVSVNVSPR
QLASGDFCSVVRRVLDASGLPAHQLELEITEGALVA--PGALPALRALNEIGVLIAIDDFGTGYSSLSYLRTFHADRLKIDMSFVRGIGTHCADEAIIRA
ILALARSLHFEVVAEGVERPDQLSFLVAEGCPIVQGYHFCRAVPAAEIPAYVRSFSMA--
>tr|B2JVI6|B2JVI6_BURP8 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia phymatum (strain DSM 17167 / STM815) GN=Bphy_5899 
-------------------------------------------------------------------TRITSQIVATEAQRRFREYFEQHPVSMLIFDVH
YEILTANAAAQRQYGATLQQLRSMP---VDQLRPSSDVEEFRRDLQQQLGSRGGTGGVRRHRRADGEIFYVDVTYHLL--DFAGRQACFVTAHDVTAHEH
AKESLRIRSRALDASRNAVIISRK-STITYVNAAFERITGRSATEAIDAELWNLIGCDISTPDARSVRMAMRAECEGARLLQCRKPDGSIYWIDLHVAPV
LDEQDRPTHFVTVFSDVSERVRYQEQLRIQAHEDALTRLPNRLGLKATLADMFGRAVAEGNKLALVFLDLDNFKEVNDTLGHTAGDQVLCEVARRLSGAV
SRDEIVVRYAGDEFVAALYGRGDDRFMAAATAMKETLTHALTVDNRLIVPQASVGVAVFPDHTQDPDTLLQYADAAMYRAKSAGPNSILLFNHDIAIQDN
RRATLAQALRHAVASEAFSLAYQPRVNPATGKASGFEALVRWHDPEHGDISPSLFVPIAEETGLIVQIGQWVFEQACRQTRTWAASLHPDIVVSVNVSPV
QFERSDLPAMIASTLERTGVSARNVELEITEGVLMA--PGSLATLRALREMGLSIAIDDFGTGYSSLGYIRSFLADRLKLDMSFVQGIGRSHADEVIVRA
VLAMGRTLGMRVVAEGVETLGQLEFLIDNGCDEVQGYWFARPMDANWAHAYLVQDSVR--
>tr|K8REW6|K8REW6_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Burkholderia sp. SJ98 GN=BURK_011161 PE=4 SV=1
-------------------------------------------------------------------AKNAARIVADEAQKRFSQYFDQHPVAMLIFDVG
GAILTANAAAQRQYRATLEQLNALT---IFDLRPAEEVANFRLDLAGYVGAGSGAGGIRRHRRLDGDVIFVDVSFHLL--SFGGHEACFITAHDVTAHEN
AKEQLHLRSRALEATRDAIVISHL-HRITYANTAFERLTGRRVADVLGAQTQAALGWDRAMPETGSLTHAMRGNVEASRLLKMSRSNGSTFWSDTYVGPI
LDDHGRVTHSITVLSDVTERVRHQEQLKRQALEDPLTGLPNRLALGELFDHAVRIARRNGDRLGFIFLDLDNFKDVNDSLGHAAGDDVLREVSRRLESSV
TPPGFVARYAGDEFVVLLPGRSQEC-LAHARQIATLLAQPMKAADATVVSVASMGVAFFPDHGSDAETLLRAADAAMYRSKSLHAGSIQVFDPEIAAAET
ARSAMVKALGLAIAKNELFVLYQPKICLRTRRVEGFEALLRWQSKEFGLVNPAQFIPLAESTGLIVQIGEWVLEQACRQAGEWAR-LSPFVVVAVNVSPV
QFERSDVPAMVARVLERSRVDPRNIELEITESTLMA--PGALPSLQALRRLDVSIAIDDFGTGFSSLGYVRSFMVDRVKLDMSFVRGIGCSRADEVIVKA
VIAMGQALDIRVVAEGVETADQLDYLIDNGCDEVQGFWLGCPMRPELAEISLMQSALA--
>tr|E1T757|E1T757_BURSG Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. (strain CCGE1003) GN=BC1003_0392 PE=4 SV=1
-------------------------------------------------------------------KKLHSVRALGRNDERFRSLFDDHPVPMYIFDRE
LRFLAVNSAAIQQYGYSESEFLDMT---IRAIRPNSEIARLESHLQRSDP-GRTMAGIWHHRRKDGSLISADISYHAL--NFMGRAAFFVLADDVTERKR
ADLALRLQSRALDASVNAILITAPSNLIEYVNPAFMRITGYDPAEVIGHDCRVLQRDDREQEGVALIREALAANREVSAVVRNYRKDGALFWNQLFIAPV
PNAEGVITHHIGVINDVTDLMRYQEQLEYQANYDSLTRLPNRNLLRDRLQHALIVAQRQHKGVAVVFMDLDGFKNVNDSLGHSVGDRLLGVVAERLARCT
RTSDTVARHGGDEFVIVMTDTVDQSLIAWMERVRASVSEPVWLDGTELYVGCSMGASLFPQDGDDAETLMKKADLAMYRAKDMGRNTFQFYQPEMNASAG
ARLNLERRLRRALRDNQFLLHYQPQVDIHTGQIVGTEALVRWHDPEGGLVPPSSFIPVAEESGLIGPLSEWVLREACRQNKAWQNLGLPPARVSVNLSAR
VFQQRDIARLVMQVLDETGLEPQYLELELTESAIMRNAEEAVSMLNELSALGIGLAIDDFGTGYSSLSYLKRFPVDRLKIDRSFVSDIGISGDDETITSA
IIALAHSLKLQVIAEGVETSAQLDFLKERACDEMQGFYFAKPLSTDAISELMKGGTAR--
>tr|W6WU89|W6WU89_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. BT03 GN=PMI06_004652 PE=4 SV=1
-------------------------------------------------------------------EKLRIAKALHRHDERFRGLFEQHPVPMYIFDRD
LRFLAVNTAAEQQYGYSESEFLAMT---VRAIRPHAEVARLESHLQRSDGGPRTMAGIWHHRRKDGSQISADISYHAM--TFMGRPALFVLADDVTERKR
ADLALRLQSRALDASVNAILITAPSNLIEYVNPAFKRITGYDPQEVIGQDCRLLQRDDRDQEGIAAIRQALSANREVSAVLRNYRKDGALFWNQLYIAPV
PDADGQTTHHIAVINDVTALIRYQEQLEYQANYDSLTRLPNRNLLRDRLQHALIVAQRHHKGVAVVFIDLDGFKNVNDSLGHSVGDRLLSVVADRLARCA
RASDTVARHGGDEFVIVMTDTVDQSLIAWMERVRASISEPVWLDGTELYVGCSMGASLFPQDGDDAETLMKKADLAMYRAKDMGRNTFQFYQPEMNVSAG
ARLNLERRLRRALRDNEFLLHYQPQVDIETGQVVGMEALVRWSDPEVGLIPPSQFIPVAEESGLIGPLSEWVLREACRQNKAWQDEGLPPARVSVNLSAR
QFQQRDIAKLVMQVLEETGLDPQYLELELTESTIMRNAEEAVSMLNELHALGIGLAIDDFGTGYSSLSYLKRFPVDRLKIDRSFVSDIGESSDDETITSA
IIALAHSLNLQVIAEGVETSTQLDFLKERACDEMQGYFFAKPLPHDAIPGMLQRGAEN--
>tr|A0A0A6Q2R3|A0A0A6Q2R3_9BURK Diguanylate cyclase OS=Burkholderia sacchari GN=NH14_30870 PE=4 SV=1
-------------------------------------------------------------------ERLRALAGTQARNERVHGLFDAHPVPMYVFDRA
LRFLAVNAAAIQQYGYSEEEFLAMT---IRDIRPADDVARLEQHLARSDQNVRMVAGIWRHMRRDGSLISADISHHSL--VFEGREAVFVLADDVTESKR
ADLALRLQSRALDACVNAILITAPGNLIEYANPAFRRITGYDPAEVIGQDCRFLQRDDRDQEGLIAMRQALVSNREVNTVLRNYRKDGALFWNQLLIAPV
PDFDGRITHHIGIINDVTELIRYQEQLEYQANYDSLTQLPNRNLLRDRLQQALVSAQRHRRGVAVVFIDLDGFKNVNDSLGHSVGDRLLGVVAERLTRCT
RTSDTVARHGGDEFVIVLTETIDKVLISWMERARSMISEPVWIDGTELYVGCSMGASVYPQDGNDAEALLKKADVAMYRAKELGRNTFQFYQPEMNASAG
ARMDLERRLRRALRDGEFLLHYQPQVEIEGGRIVGMEALVRWRDPEAGLVSPAQFIPVAEESGLIGPLSDWVLREACRQNRAWQDAGLPPVRVSVNFSAK
TFHQRDITELVKGVLQETGLDPCWLEVELTESTLMRNTEEAVSMLNALHEAGVGIAIDDFGTGYSSLSYLKRLPVDRLKIDRSFVADIGNSSDDETITAA
IIALAHELRLQVIAEGVETSQQFAFLRERACDELQGYFFAPPMPGEEAAALLSTSAAY--
>tr|A0A069PW63|A0A069PW63_9BURK Diguanylate cyclase OS=Burkholderia glathei GN=BG61_00915 PE=4 SV=1
-------------------------------------------------------------------EKLRIARAMQRSNERFRGLFDAHPVPMWIVDAE
MRFVAVNPAAMQHYGYNEPEFMNLT---LRELHCAGDFDRFAARLARSAEGGQRSAGVWRHRHKDGSTISVDMSHHAL--TYSGRPGIFMLANDVTERKR
AELALRLQSRALDASVNAILITGSVNVIEYANPAFKRITGYEPSEVIGRDCRFLQGTDQDQEGLNAIRRGLAGNREASAVLRNYRKDGALFWNQLFVAPV
PNVNGHTTHHIGVINDVTDLIRYQEQLEYQANYDTLTRLPNRNLLRDRLQHAIEEARRRDTKLSVVFIDLDGFKNVNDSLGHSVGDRLLAVVAERLARCA
RASDTVARHGGDEFVAVLPELTDRLLIAWMERVRSAISEPVWLDGTELYVGCSMGASIFPQDGDDAESVMKKADLAMYRAKDMGRNTFQFYLPEMNASVG
ARMNVERRLRRALRDGEFILHYQPQVDMATGKIVGIEALVRWMDPEQGLVSPASFIPVAEESGLIGPLSEWVLREACRQNKAWQDAGLPPARVSVNLSAR
QFQQRDIASLVLSVLKETGLEPKYLELELTESAIMRNAEEAITMLAELSALGIGIAIDDFGTGYSSLSYLKRFPVHRLKIDRSFVADIGACGDDETITSA
IIALAHSLQLQVIAEGVETSAQLDFLRARDCDEMQGYFFSRPMPRDAIPGLLREGIVL--
>tr|K8R5H1|K8R5H1_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Burkholderia sp. SJ98 GN=BURK_027230 PE=4 SV=1
-------------------------------------------------------------------EKLGAARARQRSNERFRGMFEAHPVPMWIVDSE
MRFVAVNQAAIEHFGFNEPEFMDMT---LRDLHHADDFDSFAARLARSGQSGRGSAGVWRYRCKDGSIVGADVSHHSL--IYSSRPGIFMLANDVTDHKR
AELALRLQSRALDASVNAILITGVVNVIEYANPAFKRITGYDPSEVIGQDCRFLHGPDGDQEGLTSIRRALDANMEASVVVRNYRKDGALFWNQLFVAPV
PNAQGMTTHHIGIINDVTDLMRYQEELEYQANYDTLTRLPNRNLLKDRLQHAIETARRRDAKIAVVFMDLDGFKNVNDSLGHSVGDRLLAVIAERLARSA
RTSDTVARHGGDEFVVVLPDITDAGLIVWMERTRAAISEPVWIDDTELYVGCSMGASLYPQDGDDAETVMKKADLAMYRAKDMGRNNYQFYQPEMNASVG
ARMNLERRLRRALRDGEFLLHYQPQVDMSTRQIVGIEALVRWHDPEQGLVSPASFIPVAEESGLIGPLSEWVLREACRQNKAWQDAGLPPARVSVNLSAR
HFQQRDIARLVTSVLEETGLAPRYLELELTESAIMRNAEEAITMLSELSALGIGIAIDDFGTGYSSLSYLKRFPVHRLKIDRSFVADIGSSGDDETITSA
IIALAHSLEMQVIAEGVETHAQHDFLRERDCDEMQGYLFSRPMPHEAIPGLLQQGVLP--
>tr|A0A069P6U5|A0A069P6U5_9BURK Diguanylate cyclase OS=Burkholderia grimmiae GN=BG57_21510 PE=4 SV=1
-------------------------------------------------------------------EKLGIARAKHRSNERFRSMFEAHPVPMWIVDRE
MRFIAVNPAAVEHYGYAEAEFMEMT---LRDLHVADDFDRFAARLARGGTRGQRSSGVWRYRHRDGSTSSADVSHHAL--TYSNRPGLFMLANDVTERKR
AELALRLQSRALDASVNAILITGVVNVIEYANPAFKRITGYDPAEVIGRNCGFLHGTDRDQEGLKSIRRALSADMETSVVVRNYRKDGALFWNQLFVAPV
PNAQGLTTHHIGIINDVTDLMDYQEQLEYQANYDTLTRLPNRNLLRDRLQQAIEQARRRGTKIAVVFMDLDGFKNVNDSLGHSVGDRLLAVIGERLARSA
RSSDTVARHGGDEFVFVLPDITDAGLIAWMERTRAAISEPVWLDETELYVGCSMGASLFPQDGDDAETVLKKADLAMYRAKDLGRNTYQFYHPEMNASVG
ARMNLERRLRRALRDGEFLLHYQPQVDMATRAIVGIEALVRWHDPEQGLVSPASFIPVAEESGLIGPLSEWVLREACRQNKAWQDAGLPPARVSVNLSAR
HFQQRDIATLVTSVLEETGLEPRYLELELTESAIMRNAEDAVAMLSELSALGIGIAIDDFGTGYSSLSYLKRFPVHRLKIDRSFVADIGSSGDDETITSA
IIALAHSLELQVIAEGVETPAQHEFLRERDCDEMQGFLFSRPMPHDAIPGLLQQGVLL--
>tr|A0A080LR35|A0A080LR35_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-91 GN=gmr_17 PE=4 SV=1
-------------------------------------------------------------------AERAAAEQLAASEERYRGLFRMAPLPYQSLDMH
AI-LDVNEALALLGGYTRDEVLGRP---ITDFIEEHSLPVLAGNFPNVA---HIEGLLFDLRRKDGETRTVLINGRITC-DRQGVARTHCILTDITEERR
AEAAQRLAATVFSASAEGICITDAEQRILSVNPALLALSGYTEHELIGQTPRIFSSGRHDADFYQAMWEHILAVGVWRGEVWSRRKNGEIFPEWLTITAV
RNAGGEVTHYTGTFFDISERKQWEQDIHFLAHHDALTKLPNRTLLDDRIRQAIAKSKRNDDHMAVLFLDLDHFKLINDTLGHDTGDRLLEQLAQRLTEVL
RSTETVARLGGDEFVIVIPELAARRVAVVARKVLEVVAAPYLLEGSSLHVTPSIGISVYPEDGDDAATLLRNADTAMYHAKEQGRNNFQFFTQAMNQSVQ
ERVTIENDLRLAIERGEFLLHYQPQVDCRSGEVIGMEALIRWQHPQRGLIAPDRFITIAEETGLIVPIGEWVLGEACRQARRWQLGGHPGLRISVNLSAR
QFQQWDLSARISAMIHASGIDPASLELELTESMLMIDPEKATAVLHQLAAAGVKMAIDDFGTGYSSLAYLKRFPVTRLKIDRSFVRDLANDSNDAAIVDA
VVAMATSLKMEVIAEGVETIAQLDYLEAHGCHAIQGYYYSPPVVAESFTRFHYSRRAG--
>tr|A0A099D1N2|A0A099D1N2_9ACTO Diguanylate phosphodiesterase OS=Actinopolyspora erythraea GN=IL38_19445 PE=4 SV=1
------------------------------------------------------------------------ARTLANERRKLQNAQRVAGLGTWEGNPH
TNELRLSETLLEITGTPPGTDTTFE--YYLGHTHPEDQPRVARSWRELTENHTPMEVEQRYVRPDGTMRILLCHGAVITDVA-DRPLLVGTAQDVTEQRT
AVTRMERSSQRVGVVPVGIGLFDESERLIEANDAMCELLGYPLESLRGNTISAITHPDEGSIETTTELSDIPRGRRGEVQRMLARSDGQPVYCELHTALS
VRDDGTK-SWLVVFQDVTERRRNAEALRFQATHDELTGLPNRAAVKGMLTSM-LAEGD-PDRIAVLFCDIDNFKRINDSLGHDAGDDLLVALARRLEGGL
PDGCVAARISGDEFVVICADVHEGGTDSLATRVSGLLRTAVPVRGQLVRVSASVGASVPNGTND-GADLLRFADAAMFEAKRGGPGRVSLAGPSLMASAD
SQLHLEGQLREALHHDQLTLYYQPVVDRH-GLIVSAEALLRWPHQERGLLSPGVFLPVADQGGLMRDIDRWVLRNALSEAAEWPGSGETAVSVAVNLAGM
VPGDPDFVDYVTDCVRHAGVSWDRVVLELVESSLVDLPARTRSAMEELVNRGARFAVDDFGTGFSSLARLKELPAQIIKVDRGFVSEIHSDSGDFAVAKA
VVDMAGAMGRSCVAEGVENAQQFDTLLGAGVDKHQGWFFSPPVPAPEFHAMLAGGSL---
>tr|T2S3D3|T2S3D3_SACER Diguanylate phosphodiesterase OS=Saccharopolyspora erythraea D GN=N599_06145 PE=4 SV=1
------------------------------------------------------------------------ERRLRDERRKLHDAQRVARLGTWEWDPA
TDNIRLSEMLHEIIGKSSETVISFE--SYVAAVHPDDRVWVRNAWRPLVEEHDPIEVEHRYLRGDGAVRILRMHGTAVRDAD-GRTLLVGTAQDVTEQRT
AVTRMERSSQRVAVTPVGIGLFDQAERLVDANDALCDLLGYRLDQLRGMTAQDMTHPDEDGMRQTASHQGGRGSGRRKPQRLLIRSDGEPVYCELHVALS
VQDDGTR-FWLVVFQDITERRRAAEALRYQATHDDLTGLPNRAAVKDLLGHL-LGRADSAEGVAVLFCDIDNFKRVNDSLGHDAGDELLVALARRLEGGL
PDGCTAARLSGDEFVIICRDIGTGGVDQLATRVAGLLRTAVPVHGQLIRVSASIGAAVPNGSGAGGEDLLRFADAAMFEAKRRGAGKVSLASPALMASAD
RQLHLEGQLRDALNNDGLTLYYQPVVSSD-GSIVTAEALVRWPHPDRGLLSPDAFLPVAEQGDLLRELDRWVLRTALKEAASWPSSNGRQVGVAVNLAGL
VPGGPDFVDTVADVVADVGIDWHRVILELVETALVDLPSRTRHAMGELVQRGVRFAVDDFGTGYSSLARLKDLPAQIIKVDRRFVSGVGGDASDFAVARA
VVDMARAMGRQCVAEGVETATQFHVLCGVGVDAYQGWLFSRPIPAREFRTILSMGPL---
>tr|A0A0B7CZN4|A0A0B7CZN4_9PSEU Sensory box/GGDEF family protein OS=Kibdelosporangium sp. MJ126-NF4 PE=4 SV=1
------------------------------------------------------------------------GRQRAMDRRLFEDAQRVALLGTWAWNTA
TGECVWSTMLYELFGVEPGMPMLYE--NYLEYVHPDDRAWVDRTWRQLAESGDPVVCEYRVVRPDGSIRVLRCRGASFAGRT-EGPVMVGTAQDVTEQRS
TESRMQRSSQRVAITPVGIGLFDVSERLVDANDALCRLLGMDLERLRGMTAEQLTHSEHDPQ------------ARLAGQRVLATAAGDPVYCELNVVSS
VADDGRR-FWLVVFQDVTERLRAAELLRHQATHDDLTGLPGRVAVKELLTEV-LSASC-AKDVALLFCDVDNFKRVNDSLGHDAGDELLIALARRLEDGL
PDGCTAARMSGDEFVVICPDQNDGGVDALASKVAHLFRTAVPVRGQLLRVSASVGAAVPSGPETTGADLLRFADAAMFEAKRRGAGRVSLANAALIATAD
SQMYLEGQLREALGNDGLVLHYQPVVGVD-GAILTAEALVRWPHPDRGLLSPGQFLPVAEQGDLLRDLDRWVLRTALREARSWPEVDGRQVSVAINLAGL
VPGDPEFVDVVATAIAGSGVEWERVVLELVETSFVDLPSRSRTAMADLVSRGVRFAVDDFGTGYSSLARLKDLPAQIIKVDRRFVAGIGTDPSDFAVARA
VVDLTRAMGRTCVAEGVETDTQFSALRDIGVEAYQGWLMSRAVPADEFRELLRLGPL---
>tr|W7IYW2|W7IYW2_9PSEU Sensory box protein OS=Actinokineospora sp. EG49 GN=UO65_2656 PE=4 SV=1
------------------------------------------------------------------------ERQLSQDGRLFRETQRVARMGTWEWDTA
TGDCVWSSMLYDLAGIAPGTAITYS--DYLRIVHPDDRGWVDQRWQELASARRPVECEHRVVRPDGKRRVFRVRGEAA--DP-DRGVMIGTCQDVTEQRS
TETRMQRSSKRVAITPVGIALFDDAERLVDANDALCSLLGMDLERLRGTTAEQLTHPDDRESRG-------RDTPAFHGQRVLSTAAGKPVYCELNATVS
VTDDGRR-FWLVVFADVTDRRRTAERLRHQATHDELTGLPGRAAVKELLATL-LGGRD-YQRIALLFCDVDNFKRVNDSLGHDVGDELITALARRLERGL
PPSCTVARMSGDEYVVICSDVDEGGVEVLANQVASLLRTAVPVRGQLLRVSASIGAAVPTGPETSGADLLRYADAAMFAAKARGTGRVSMASDALIASAN
SQMLLEGQLREAIANDQLVLHYQPVVGPD-GTVLSAEALVRWPHPERGLLMPGEFLPVAEQGDLQGELDRWVLRTAFTEAAEWPQLCGGVVAIAVNLAGL
VPGDPDFVDIVTSCVAATGISWDRVILELVETSLIDLPSRSREAMAELVERGVRFAVDDFGTGYSSLARLKELPAQIIKIDRRFVSGVATDASDFAVARA
LVDMARAMGRSCVAEGVENATQFHVLRGVGVDAYQGWLMSRPIPAREFRELLKLGPV---
>tr|A0A073B6B6|A0A073B6B6_9PSEU Diguanylate phosphodiesterase OS=Saccharopolyspora rectivirgula GN=GU90_18795 PE=4 SV=1
------------------------------------------------------------------------QNQLLNERRKLEEAQRIAHLGTWEWEPL
RKTFLLSPMLREVLGENR-SRISFN--DYLNQVHPDDRDYVRKAWRPLAQHRQPVEVEHRYLLADGSVRLLRVHGQAVSHG--GHWTVVGTAQDVTEQRA
VIARLQRTTQRVAITPVGIGLFDASERLVDANKALCDLLGYQIEELRGMSIGELTHPAELEQRPRPPRQD----QPHRLQRIMLRSDGEPVYCELHVTLS
VQDDGTQ-FWLVAFQDITERRRTAEALRYQATHDDLTGLPNRSAVKDLLRRL-WQWAD-THSIAVLYCDIDNFKRINDSLGHDAGDELLVALANRLEEGL
PPGCIPARISGDEFVIICQDLEPGGIDELISQVAALLRTPVPVGGQLLRVTASIGAAMPNGATRHGEDLLRFADAAMYEAKQRGSGKITIASPDLIANAN
HQMQLEGELREALHWDELVLHYQPVVDSD-GWTISAEALLRWQHPERGFIGPNVFIPVAEQGDLLPDLDRWVLRTALAEARTWPAVNGKPVRIAVNLAGL
VPGTPGFVEAITDIINESGIDQDRVVLELVETTVVDLPARPRREMRELGRQGVRFAVDDFGTGYSSLARLKDLPAQIIKIDRRFIAGVGDSGPDYAVARA
VVDMTRAMGRECVAEGVETPTQFRLLAEAGAHAHQGWLFSPAVPAEEFRHLMRQNFL---
>tr|A4FDK0|A4FDK0_SACEN Saccharopolyspora erythraea NRRL2338 complete genome OS=Saccharopolyspora erythraea (strain NRRL 23338) GN=SACE_2846 PE=4 SV=1
------------------------------------------------------------------------EWKLRDEQQRVVDAQQLARLGTWEWDPG
SGRTRFSDLLYELTGRNRAETTTYH--GYLERVPADERRRVHRIWQGLRRDRQPVEFEHRYVRLDGSVRVWRMHGAERHDIA-GRPRLLGTVQDVTEEHA
AQSRL----RRCELAPVGVGLFDQEERLVHANPALCRLLGHSPEQLRGMTTEAISEPGEQNRWL---PDAARGSGTAPPRRWLRRRDGDSVYCELHSTES
VQDDGTR-FWLVVFQDVTEPFRTAEILRHQATHDELTGLPNHTAVKAALGDL-LASAG-ADRVAVFLCDIDNFKRINNSLGHDAGDELLVALARRLESRL
PRECTPARLSGDDFLVVCSDIDAGGVESLARTMSGLLSTAVPVHGQLIKVSVSIGAAMRHDPLTTGGDLLRFADAALSEAKRQGSGRLSLAGPALRDAAN
QQVHLEGELRKALQDGELEMHYQPVVSDD-GTIVTVESLLRWPHPERGMLRPGAFMPIAEQGGMLRDLDLWVLRTCLREAADWPLARGAPVRIAVNLSAL
VPGDPGFVDTVREAITDSGIAPSRVILELVETALVDLPDRSRQAMDELTRYGVRFSVDDFGTGYSSLARLKDLPAHTIKLDRRFVSGVVTDPADLAVAKA
VADIAHAMRRRCVAEGVETATQFHVLRGIGVNGYQGWLFSYPLPARELLPLLRKGHL---
>tr|F4CRQ4|F4CRQ4_PSEUX Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudonocardia dioxanivorans (strain ATCC 55486 / DSM 44775 / J
------------------------------------------------------------------------ELGSGSDARRIAELERMARVGTWTYELA
SATLRRSASLQDLYRGAGIDPDGPD--G------PIEGEQVALLCQGLRNGVRG--GDHHVDLKLPGDRLLGCRASVERADDGTPVRLVGTVRDLSAQRL
AENRHRAAGARVALLPTGVLLFDATGRVIDANPAVCEILDTVPEDLRGTTAAALSAPDGLPDWRRVPPGVDNG---YRDALPLLRSDGTRVWCGVGVTVT
RADDGAP-LFLVVCEDVTDRRRAAEVLRSAGTVDALTRLPNRAAALHLVDGL-LAGPG-RDGVVLVCGDLDDFSRVNSSLGHDAGDDLLVTLAGRLQREL
PFGCTAARLSGDEFVVICSDHTEGGPEALAHTVAALLRTSITVGGRPVEVTASVGLATPADPDLRAADLLRFAEVAMYEAKKRSRGGVGVATDVVVRTAT
SQLGLEAELRAAIADDRLVLEYQPVVTAD-GRVRSAEALIRWPHPDRGLVPPGEFLPVAQRGGLMRELDLWVLRTAAREAAGWQSEG---IAVAVNLAGL
LPGDPEFAELVTGTLQATGLDHSRLILELVETSLVALPPHALAAMADLVGRGVRFAVDDFGTGYSSLARLKELPAQTVKVDRAFVTGIAEDPVDHAVARA
VVDMARAMGRSTVAEGVETAAQFEALRGIGVDAFQGWLFARPLPVEQMREVLRSGRL---
>tr|D1CDW9|D1CDW9_THET1 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thermobaculum terrenum (strain ATCC BAA-798 / YNP1) GN=Tter_020
------------------------------------------------------------------------GISLVSATA-LTHLEACLDIPMLIIDQN
LSISYASKSLQNLINFVPKALIAS-----LELIHREDQETAK---ELILQQNQAHEVDVKLRR--AGDGWIRVRAYSG---RLPSNLILMLIQDVSLTES
LRVQLEIEHAK--EIAE-------RTGQEVWSDQTFKIYGLKPGSLEPSYEYLLRIPDDRDRVDSAYRDSIKALSAYDVSYRILLPDSSIRVVHSKAQIV
KGADSHL-LLTGTVQDVTEQKVNEESLLRQALHDPLTGLPNRVMLGQQLEKL-LASNRSRS-IAVLFLDLDNFKAVNDNLGHQAGDSLLVAVARRLSANL
RPTDFAARFGGDEFTVVVTKVKSDYVVSIAKRIIESISQPFDIAGERVYTSTSIGIALCSSSEDSASSLLRKADIALYKSKSLGRGTYVIFDQSMEQEAS
EILELERNLRTAIQNDQFIVHYQPIVDAATGKVEMIEALLRWNSPNG-ILSPDKFIPIAEEVGLINTLGELVLNKACEQTAYL-KATGAKFITSINVSAK
QLRQPHFTNNLESMLHKYDLQPKDVQLEITENALVEEVECITNALKEIKTLGIRIAIDDFGTGYSSLSYLRKLPIDLIKIDQSFVKMLPNDEEHRAIIYT
IISLACSLDLEIIAEGVEEKSQREILLSMGCKFIQGNLISHPVDLESIKLILGHTSP---
>tr|H8YYS4|H8YYS4_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiorhodovibrio sp. 970 GN=Thi970DRAFT_01272 PE=4 SV=
------------------------------------------------------------------------ALWSNEREQMLSHAARLAQVGGWTLEPN
SSRFRPTVHWCHLHGVEPGE--TLD--SLLRILHPDDRAGMLAAIQRALEENAPCVHQHRIIRPDQRTRFIQDYGEFLYDANGKPTALCGAAQDITERIR
MQDAIRDTEEHLQLSKT----------------------------------------AELKIEFRVLW-----------------PDGSSHWLATDGDAI
RGANGRAIRLAGVARDITERKTSQIRLEQLAYYDHLTGLANRRLLLDRLRQAIAVAERENTQIAVCYLDLDDFKPVNDQCGHEVGDILLQAVAARLVSCV
RPSDTIARWGGDEFALLFADVVDDACIQILDRILHGLNERLI-KEQPQPVSASIGVTLYPQDHGDADSLLRHADHAMYLAKQCGRNNYQFFDPEKDPLGI
ANRERLRDIQQAINAGELRLLYQPIVNMRSDSVESVEALVRWQHPRRGLLAPGEFLPAIEGSDLIRQLDHWVLREALTQQEAWIRQGL-QLRLHINVSAY
SLLTPDFMLEVSGFIGHPGVRPGGIELEILETAALDDLDLVSTVIRQGTLLGLSFSLDDFGTGYSSLTYIRRLSARTLKIDQTFVRDMLNNQEDRAIVEG
VIGLARAFNLAVIAEGVETLEHGCLLMRLGCDRAQGYGIARPMDAERLTEWATAYRQ---
>tr|K6ZXX1|K6ZXX1_9ALTE Cyclic di-GMP phosphodiesterase Gmr OS=Glaciecola polaris LMG 21857 GN=gmr PE=4 SV=1
---------------------------------------------------------------------------IQRQDLLLKESQKIAKVGGWELDVV
TGNLLWTDETYRLHDTSPDEFNTVD--AGLGYFLPESKKAIESALNEAITNGKGYDLELETYTTKGRKISVRTTCKVTAK-NGKSVKLTGIFQDISAEKE
KERALFEANKA------IVSIANVA-KITYVNDKFCAISGYNREELLNKNHKIIKSAEHPDAFFVDLWRTISGGQTWQGEIRNTAKNGTDYWVKTTIVPT
LNDEGKPFQYVGIRTDITERKEAEEKLARIAYYDSLTDLPNRVLLEDHISVAMKQCQRHNISLAVACLDLDGFKVVNDTYGHDMGDELLIALSRRMEKAL
REGDMLSRIGGDEFIAVIVNVENEDSKAVLERLLCAASAPITVRDTVIQVSASIGFTIYPQDDAKEEELVRHADQAMYIAKLAGKNRYHMFDIANNDAIK
TQRQSIADVQEAMGKHEFVLHYQPKVNMRTSEVIGVEALIRWQHPERGIVPPLDFLPAIEGQAISVELGEWVIDTALKQISQWQGLGV-NLPISVNVSAY
HLQRLNFTSRLATLLAHPEVEPYTLELEILETSALSDIDEVSGIMNVCHELGVGFALDDFGTGYSSLTYLKRLPAHLIKIDQSFVRDMLKDADDLAIIEG
VVGLAKAFQREVIAEGVETIEHGLALLKLGCELAQGYGIARPMPSGDIPEWISSWKA---
>tr|B3PKS7|B3PKS7_CELJU Diguanylate cyclase/phosphodiesterase domain 2 (EAL) OS=Cellvibrio japonicus (strain Ueda107) GN=CJA_0834 PE=4 SV=1
------------------------------------------------------------------------EEQLRTSARLLEASQAIANVGSVEMEFP
SRRLYWSAETYRIHDTSPEEYTTFD--LSLDHYLPDSRQKLQAALQKALETGEVFDLELEKYTFKGRKIDVRTTCTATFDQLGRLIRLTGIFQDISARKQ
AERYQLHHSHILQHAPLGILITDAQ-NIIEVNTTFTDITGYTRDDVIGKNPRLLQSNKHDAVFFERLWHSLVNEGAWCGEIWNKRKNGDLYVASMTISAV
KDSRGQITHFVDLFNDITHIKEHQRQLEHIAHYDALTHLPNRVLLADRMKQALLHSQRSGLSLAVMYIDLDGFKAINDQYGHDLGDQLLVAISSRFKSVL
RESDTLARIGGDEFVVVLNELEQAAYQPVLDRLLATAADPLILRDQALRITASIGITLYPSDTADAEQLIRHADQAMYLAKQRGKNGWHLFDVDRDVATK
HQYESLERIRLALEQREFILHYQPKVNMKTGALVGAEALIRWQHPTRGMISPGEFLPLIEEHPIGLDVGEWVIDTALSQIEHWQREGL-ALPVSVNLCAL
QLQQGRFAQRLSELLQHPDVAPGQLELEIVETSALADMTDVANTMRACNALGVRFAVDDFGTGYSSLTYLKRLPAETLKIDQSFIRDMLDDPDDFAIVKG
VISLAQAFHRQVIAEGVESVAHGEMLIPLGCELAQGYGIARPMLAGEISSWIQRWTP---
>tr|A1SWA5|A1SWA5_PSYIN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Psychromonas ingrahamii (strain 37) GN=Ping_2006 PE=4 SV=1
------------------------------------------------------------------------EELMIVTSQLLNESQQIGRLGGWKLDLK
TGDLFWTDETYRIHETSPEEFNTVD--AGIGYFLPDSQKIISKALDEAINNGIGYDLELQTYTTKGRKIDVRTTCIVTQE-DGVAVRLTGIFQDISEQKA
NQRKLEKSNLD-----------------------------------------------------------------------------------------
--------------------ANANSALKLSAHYDPLTGLPNRILLADRIQQAVAKSLRNDKYVAVAFIDLDGFKAVNDSHGHTIGDELLKKVAKRLKHVL
REGDTLSRFGGDEFVAVIDNLSDRESDLIVLRMLESVSSTLVVEKKLLKISASIGVTFYPLDSAGPEQLLRHADQAMYMAKQQGKNRSYVFDIEQDVAIK
HHNEALKRIAQALKNNEFALYYQPKTDLRSNRVVGVEALIRWNHPDRGVLAPAMFLPAVEHDILDIEIGKWVIKTALQQSQNWLSSGT-DIPISVNISPL
HLQHAEFVSELKRMLDYPNINAGSLEFEILESSALKDIELVSKVMKECNQLGVRFSIDDFGTGYSSLTYLKRLPAETLKIDQSFVRDMLIDTDDKAIIQG
IIELAKVFNLKVIAEGVETPQHGELLLSLGCYFVQGYGIAKPMHENDVLTWLVKWEK---
>tr|Q07ZS0|Q07ZS0_SHEFN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella frigidimarina (strain NCIMB 400) GN=Sfri_2654 PE=4 S
------------------------------------------------------------------------EELLATTTELLRESQEIGKLGGWQLNLH
NGDLIWTDETYRIYETTPQEYITVE--MGVSYLLPDSKKLFQEALDAAIQLGEEYDLELETYTTKGQKIDVRTTCHVTYV-DGVAEKLSGIFQDITDEKN
NQRKLEKSNQV-----------------------------------------------------------------------------------------
--------------------KEVNEKLKFAANYDPLTHLPNRNLLADRMQQALIKAQRNSKQIAIAFLDLDGFKEVNDAYGHDIGDEFLCLIANRFKTAI
REDDTLARFGGDEFVLILDDLDSQEASEILQRILSSITEIFIIENKRLSITVSIGVTFFPQDNSHADILIRHADQAMYRAKEQGKNCIHEFDFENDVAIK
LQYRELEYIINGFNNNEFLLFYQPKINMESNEIIGLEALIRWQHPTEGLLSPFRFLPYIEEEPLAIELGKWVIDQAIKQHNEWRRLGI-VIPISVNVSPL
QLQHEDFIKQLNEILFNTSFQAGQLEFEILESSIIKDTQHIAEVISQCKQLGIRFSLDDFGTGFSSLSYLRKLKTDVIKIDQSFVIDMLDDMDDQAIVKS
VIELSKTFGRSVIAEGVETQEHGRQLLKMGCQLAQGFGIARPMPASSIPEWINLWNA---
>tr|A0A085F8R2|A0A085F8R2_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia sp. LC238 GN=FG94_02995 PE=4 SV=1
----------------------------------------------------------------------------LSDARALELLLQNLPAYRCRYDAD
WTMEFISDGVEKLTGYPAAAFLRSL--NFASLIHPGDRAGAERGVALALQQGRSFKLTYRIRCANGETRWVYEQGAAPPQ--GRGEILEGFMFDYTELRN
ANMLVQEQASY--QARD--------SRITYWNNGAERLYGWSALEARGKK--FSD-LCGEQRAYHAAYENTLANGEWTGELSHLRRDGVTRWTLMA--AD
RESGALQ-KILVISTDISERKHNEAKIYRLAFFDALTDLPNRASLLDHLRRALLGSARTRKCGALMFCDLDKFKYLNDSQGHAAGDMLLQAVARRLEHCV
READMVARLGGDEFVILIQPVEDAQAETVASKVVAAMAAPFQLADMMYSVSVSVGVTTLCGTVDTVESTLRQADAAMYQAKACGRNTYRFHDPAVQAAWS
ARAELEGAMRRALRDNEFVLHYQPQLDRS-SRVIGAEALLRWRLPDGQLLYPAEFIQAAEESGLIIDIGRWVLRTACAELARWQRFDTAGLTMSVNVSAG
QFMEPDFVPMLQQVFEETGVQPSSLKLELTESLVVSDFTHTAHTMATLKQRGISFSLDDFGTGYSSLAYLRKLPLDQLKIDQSFMRDVLTDQNDASIVRS
IIALGESLGLQVIAEGVETPGQRQFLSDAGCYIYQGFLYQHALSAEHFTQYARTVH----
>tr|K9E202|K9E202_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia timonae CCUG 45783 GN=HMPREF9710_01313 PE=4 SV=1
------------------------------------------------------------------------SAQLPEQAGALDLLLSNLPVYRCHNDPD
WTIEFISEGVEKLTGYSPAAFTRPL--PFGSIILPEDRVLVDGAIALALAQGRAYQVTYRIRTASGDVRWICEQGSLNLT-GGPPGMLEGFLSDFTRLKK
ADLKMQEQASF--RARD--------SVITYWNHGAERLYGWSAREALGKR--FCD-LCDKPALYEAAFRQTLESGEWAGELAHIRRDGSTSWTLLG--PD
QALDACQ-KILVIGTDISERKSNEARIFHLAFFDHLTDLPNRANLLDHLRRALLTSTRTRKWGALMFCDLDNFKFLNDSQGHAAGDQLLQAVARRLEHCV
READMVARLGGDEFVVLIQPVEDNQAEIVAAKVVAALAAPFQLGELSYSVSVSIGVVTLCGVHDTVESTLRQADAAMYQAKAAGRNTFRFHDPAAQAAWS
ARAELEGSLRRALQHDEFVLHYQPQLDRS-GRVLGAEALLRWRLPNGRVLYPGEFIRAAEESGIIVEIGKWVLRTACAELARWQRVETAGLTLSVNVSAR
QFNQPDFVPMLQGIFEHSGVQPSSLKLELTESLVITDFTQTAHTMATLKRRGLSFSLDDFGTGYSSLATLRKLPLDQLKIDHSFMRDVLTDQNDASIVRS
IIALGDSLGLQVIAEGVETPGQRQFLSDAGCYLYQGFLYQHALSAEHFTQYARGIH----
>tr|A0A0D7UZF0|A0A0D7UZF0_9GAMM Diguanylate cyclase OS=Halomonas meridiana GN=VE30_10885 PE=4 SV=1
------------------------------------------------------------------------EKQLRRNQRLFRIAGETAHIGGWYMDLA
VGLPIWSEEVCRLHDMPV-GHQTLE--EAIAFYTPSSRTRIQAVFTNCCEKGISFDEELEIITQQGRRRWVRVIGRAVRDELGKIIQAQGSTQDITE---
-----------------GVVIVDAQLPIVYVNAAFERITGYSREAALGRNCRFLQGIDTDPATQVQLRKGIKEQRDVHVVIRNYRRNGAPFWNDLYISPV
RDEAGVVTHFIGAQNDITAQREYQAQLSHNANHDALTGLPNRLLLDQRLAQGCLLARRYQRYLAVLFIDLDDFKPINDTLGHEVGDYILLEVAKRLEEEL
RPWDTVARFGGDEFIVLLPDLAHDDVLQVVERLLARVSAPYWYRSNELRITASIGIATNDGTIQTPRQLIQQADLAMYKAKRRGRNTFQWYTDELNRKVT
ERVNLRHALQQAIEQEQFELHYQPQIHH-SGRVAGVEALIRWYHPERGNIPPGQFIPLAEDTGQIIPISEWVMETACRDAVVLNAESATPITMAINVSPM
QFQRPGFLDSVKQVLARSGLPPALLELELTEGVLMDSAEHTIQALQALRQLGVHIALDDFGTGFSSLSYLKRLPINKLKVDRSFVGDVAVDSRDAAIVEG
VVTMADKLGLEVLIEGVETAEQFHFLRTLQCDHYQGYYFARPMALSALKAYLKTPLV---
>tr|A0A0B1PXP1|A0A0B1PXP1_9GAMM Diguanylate cyclase OS=Halomonas hydrothermalis GN=PZ78_08655 PE=4 SV=1
------------------------------------------------------------------------EKQLRRNQRLFRIAGETAHIGGWYMDIA
AGVPIWSEEVCRLHGMPV-GYQTLV--EALGFYEARSQERIRAAFTACCEQGVSFDEELEIVTQHHQRRWVRVIGRAVRDELGQIIQVQGSTQDITQ---
-----------------GVVIVDAQLPMVYVNAAFERITGYSRDAALGRNCRFLQGEETDSTTLALLRKGIQAQRDVHVVIRNYRRNGAPFWNDLYISPV
RDDDGVVTHFIGAQNDITAQREYQAQLSHNANHDALTGLPNRLLLDQRLAQGCLLAKRYHRYLAVLFIDLDDFKPINDTLGHEVGDFMLLEVAKRLEEEL
RPWDTVARFGGDEFIVLLPDLAHHDVLQVVERLLARVSAPYWYRGSELRMTASIGIATDDGTIKEPRQLVQQADLAMYKAKRRGRNTFQWYTDELNRKVT
ERVNLRHALQQAIEQHQFELHYQPQIDH-RGRVAGVEALIRWHHPVRGNIPPTQFISLAEDTGQIIPISEWVLATACRDALELNALNDTPITVAINVSPM
QFQRPGFLTSLEQVLADSGLAPALLELELTEGVLMDSAESTIQALQAIRRLGVHIALDDFGTGFSSLSYLKRLPINKLKVDRSFVRDVANDTRDAAIVEG
VVTMADKLGLEVLIEGVETAEQFAYLRQLQCDHFQGYYFARPMSLTALKDFLRTPLA---
>tr|F7SNC3|F7SNC3_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halomonas sp. TD01 GN=GME
------------------------------------------------------------------------EKQLLRNQRLFQIAGETALIGGWYVDMS
ERMPIWSNEVCRLHGVPD-GFQTIE--EAIDFYTPSSRPRIRQVFEACCEQGISFDEELEIITRQDVRRWVRVIGKALRDELGEVIQVQGSTQDITE---
-----------------GVVIVDAQLPIVYVNAAFERITGYSRDTALGQNCRFLQGEETDPATLKKLRKGIYSQQEVHVVIRNHRRNGMPFWNDLYISPV
RDATGAVTHFVGVQNDITAQREYQAQLRHNASHDALTGLPNRLLLDQRLAKGCLLAKRYHRYIAVLFVDLDDFKPINDMLGHDVGDHILIEVAKRLEKEL
RPWDTVARFGGDEFIVLLPDLAQKDVLQVVERLLACLSAPYWYRDSELRITASMGIATNDGTISEPRQLLQRADLAMYKAKRQGRNTYQWYTDELNRKVS
ERVNLRHALQQAIEQSQFELHYQPQIHGPTGRVSGVEALIRWYHPERGNIPPGQFISLAEDTGQIMPISEWVLERACCDAVRLNASANMPVTMAVNISPM
QFQRSGFLASIQRVLESSGLAPELLELELTEGVLMDSTEHAIQTLQDLRSLGVHIALDDFGTGFSSLSYLKRLPINKLKIDRSFVRDVVNDSRDAAIVDG
VVTMAAKLGLEVLIEGVETAEQYAYLNAHYSTYFQGFYFARPMPLSDIRAFLHQSPY---
>tr|H0J1I9|H0J1I9_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halomonas sp. GFAJ-1 GN=M
------------------------------------------------------------------------EKQLLRNQRLLEMAGESALIGGWYVDVV
NNVPVWSDELCQIHGMPP-GFKSVE--EAFAFYAPGSREQLMRDFQACSDTGISFDGEYEVITRQGRHLWVRAIGRAVRDEHGEIFQIQGSTQDISH---
-----------------GVIIVDALLPMVYVNAAFERITGYSRQAVLGRNCRFLQGEDTAPESRRQLRKGINAQREVHVVIRNYRCDGTPFWNDLYISPV
RDEAGVVTHFIGVQNDITSQREYQAQLRHNASHDALTGLPNRLLLNQRLAQGCLLAKRYHRYLAVLFVDLDDFKPINDTLGHEVGDFLLIEVAKRLEEEL
RPWDTVARFGGDEFVVLLPDLAHQDVLQVVERLLARVSSPYWYRTSELRISASIGIATDDGTMSEPRQLIQQADLAMYKAKRRGRNTYQWYTDELNRKVT
ERVSLRHALQQAIEQDQFELHYQPQVCQ-RGRVAGVEALLRWYHPERGNIPPVQFISLAEDTGQIMPISEWVLATACRDAVALNAAGHGPITMAVNVSPM
QFQRPGFLASIEKALQESGLAPELLELELTEGVLMDSAEHTIQALHALRRMGVHIALDDFGTGFSSLSYLKRLPINKLKVDRSFVREVVNDRRDAAIVDG
VVTMADKLGLEVLIEGIETAEQFNYFKGVQRAHFQGYYFARPMPLAAFYAFLQSPLT---
>tr|A0A060BAP8|A0A060BAP8_9GAMM Diguanylate cyclase OS=Halomonas campaniensis GN=FF32_05620 PE=4 SV=1
------------------------------------------------------------------------EKQLIRNQRLFQIVGETALIGGWYVDMS
ERLPIWSNEVCRLHGVSP-GFRTVE--EAIDFYAPSSRPRIREVFEACCEHGISFDEELEIITRQEVRLWVRVIGKAVRDEQGQVVQVQGSTQDITE---
-----------------GVIIVDAQLPIVYVNAAFERITGYSRDTVLGQNCRFLQGEETDPTTLDQLRRGIRAQQEVHVVMRNYRRNGVPFWNDLYVSPV
RDTAGAVTHFIGVQNDITAQREYQAQLRHNACHDALTGLPNRLLLDQRLAQGCLLAKRYHRYIAALFVDLDDFKPINDTLGHEVGDYMLIEVAKRLEEEL
RPWDTVARFGGDEFIVLLPDLAHKDVMQVVERLLARLSAPYWYRGSELRITASIGIATDDGTISEPRQLIQQADLAMYKAKRQGRNTYQWYTDELNRKVS
ERVNLRHALQQAIEQSQFELHYQPQIHGSTGRVSGVEALIRWYHPERGNIAPGQFISLAEDTGQIMPISEWVLERACRDAVRLNANASKPITMAVNISPM
QFQRAGFLLSIERVLEQTGLAPESLELELTEGVLMDSTEHVIQTLQDLRSLGVHIALDDFGTGFSSLSYLKHLPINKLKIDRSFVRDVVNDTRDAAIVDG
VVTMAAKLGLEVLIEGVETAEQYAYLSARHSTHFQGFYFARPMPFSAIRSLLHESPY---
>tr|G9EBS6|G9EBS6_9GAMM Putative uncharacterized protein OS=Halomonas boliviensis LC1 GN=KUC_1328 PE=4 SV=1
------------------------------------------------------------------------DEQLLRNQRLFKIAGETALIGGWYVDLA
GGKPIWSDELSHIHGMPA-GFQSVE--EAFAFYAPESRERLMAAFKACCEYGVSFDDELEVITRQGRHLWVRAIGKAVRDEEGRIIQVQGASQDITEQKQ
LRENLTQLAHRLDSITDGVVIVDAQLPMVYVNAAFERITGYARNQVLGHNCRFLQGDETDPATIKQLHAGIVEQREVHVVIRNYRRDGTVFWNDLYISPV
LDENAEVTHFIGVQNDISEQREYQAQLAHNAHHDALTGLPNRLLLGQRLEQGCVLARRYQRYIAVLFIDLDDFKPINDTLGHEVGDFILVEVAKRLENEL
RPWDTVARFGSDEFVVLLPDLAHDDVIQVVERVLRGLSPPYWYRGSELRITASIGIAINDGSMKNPRQLIQQADLAMYKAKRRGRNTYHWYTEDLNRKVS
ERVSLRSALQQAIEQQQFELHYQPQIHAPSGRVVGVEALIRWQHPERGNIPPSDFISLAEDTGQIIPISEWVLATACRDAQQLNGLGLGEITMAVNISPM
QFQRPGFLASIEQVLASSGLTPVLLELELTEGVLMDSAEQAIQALKNLRALGVQIALDDFGTGFSSLSYLKRLPINRIKIDRSFVRDVISDRHDAAIIDG
VVAMAGKMGLEVLVEGVETAEQFGYLQQRHCDYFQGYYFARPMPLGALREFLHKPPA---
>tr|A0A0D5LXZ2|A0A0D5LXZ2_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halomonas sp. KO116 GN=KO116_00257 PE=4 SV=1
------------------------------------------------------------------------QAQLLSNQRLFQIAGETALIGGWYVDMD
AGQPNWSDEVCRIHGLLP-GFQTVT--QAIEFYTPSSQSRIHEVFAACCEKGTSFDEELEVITYQGKHIWVRVIGKAVRDERGEISQVEGSTQDITEQKQ
LRENITQLAQRLDSITDGVIIVDAQLPMVYVNAAFERITGYARSEALGRNCRFLQGEDTDPATVKLLREGVTEQREVLVVIRNYRRDGSIFWNDLYISPV
RDETGDVTHYLGVQNDVSEQREYQAQLTYNANHDALTGLPNRVMLGQRLEQGCVLARRYQRFIAVLFIDLDDFKPINDTLGHEVGDFILIEVAKRLEDEL
RPWDTVSRFGSDEFVVLLPDLAYNDVIQVVERVLQRLSPPYWYRGSELRITASIGIAINDGNMKNPRQLIQQADLAMYKAKRRGRNTYHWYTEDLNRKVS
ERVSLRSALQQAIEQQQFTLYYQPQIHAPSGRVVGVEALIRWQHPERGNIPPSDFISLAEDTGQIIPISDWVLATACRDAQQLNAMGVGPITMAVNISPM
QFQRPGFLASIEQVLAQSSLAPVLLELEITEGVLMDSAEQAIQALEDLSALGVHIALDDFGTGFSSLSYLKRLPINKIKIDRSFVRDVITDHNDAAIIDG
IVAMAGKMGLGVLVEGVETLEQFTYLEKCHCHYFQGYYFARPMPLDALRAFLASPPV---
>tr|J0KPI2|J0KPI2_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein (Fragment) OS=Acidovorax sp. CF316 GN=PMI14_02342 PE=4 S
------------------------------------------------------------------------RAALREQTDVFNTMESLAQHWRRIEDPG
ETVLLWSPGLCDIAGVERQEWMPE----AVSGILAEDRHVFE----TARERGTGADVEYRWKRPDGEIRWMRSRVRRLTA-KDGMRVDMGVVQDVTDERR
AAEQLREQLLF--RIAS-------LTSVQYISDAVRDFMGVEPHEVTADHGVLSNWAEDRPVLQRSALQSVRKLVPWQCEYRVRMPD--IRWHMTNAVPH
READGSV-ISHGFTMDITDRKRAEQEIERLAFYDALTGLPNRRLLLDRLQRSIAACQRSKNLGALLFIDLDNFKDLNDTLGHDMGDQLLSQVATRLVGSV
READTVARFGGDEFVVMLDNLNPAQAETVAEKLLASLNQPFALGGQQHYSTPSIGITLFGDERLSVDELLKRADLAMYQAKAAGRNTQRFFDPDMQAAVN
ARSNLEADLRQGLARSELLVHYQPVVDHQ-ARLVGAEALVRWRHPQRGMISPGDFIPLAEQTGLILPLGQYVLETACRQLQRWSQSATAQLSISVNVSAR
QFRQPGFVAEVLGTLKDCQARPQLLKLELTESLLLGDIEDTIVRMEQLKAEGVGFALDDFGTGYSSLSYLKRLPLDQIKIDQSFVRDVLSDPNDAAIVRT
ILALAKSLDLQVVAEGVETTGQLGFLRLHGCEGFQGYLFGRPVPV---------------
>tr|K0HWE1|K0HWE1_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. KKS102 GN=C380_17645 PE=4 SV=1
------------------------------------------------------------------------RVSLREQTDVFNTMESLARHWRRIEDPG
ETVLLWSPGLCNIAGFEQQEWVPE----AVSGILPEDRHVFD----KIRERGSGLDVEYRWRRPDGEVRWMRSRVQRTLP-RDGVQVVMGVVQDVTDEHR
AAEQLREQLLF--RIAS-------STSVQYISDAVREFMGVEPHEVTADHGVLSHRAEDLPLVQRSAMLSVRKLVPWQCEYRVRMND--VRWHMTNAIPH
READGSV-VSHGFTMDITDRKLAEQEIERLAFYDALTGLPNRRLLLDRLQRSIAACQRTRNLGALLFIDLDNFKDLNDTLGHDMGDQLLAQVAARLVGSV
READTVARFGGDEFVVMLEALAPTQAETVAEKLLASLNQPFNLDGAQHYSTPSIGITLFGDERLTVDELLKRADLAMYQAKAAGRNTQRFFDPDMQAAVN
ARSNLEADLRQGLARGELLVHYQPVVDHH-ARLLGAEALVRWRHPQRGMISPADFIPLAEQTGLILPLGQYVLQTACEQLQRWSQHDTAHLSISVNVSAR
QFRQPGFVAEVLQTLKNHNADPRQLKLELTESLLLGDIEDTIARMVQLKSEGVGFALDDFGTGYSSLSYLKRLPLDQVKIDQSFVRDVLTDPNDAAIVRT
ILALAKSLDLEVVAEGVETTGQLSFLRLHGCEGFQGYLFGRPGPAETIDALLDPAG----
>tr|A0A024J3J1|A0A024J3J1_RHIRD Diguanylate cyclase/phosphodiesterase OS=Rhizobium radiobacter GN=BN949_05603 PE=4 SV=1
----------------------------------------------------------KVVKFAS---VVTEERLLQAEYQGQIAAINQAQCVIS-FALD
GTVIDANDNFLELTGYRFGEVYGQH---H-SMFVSADAA-DSDEYRSELGLGRHKAGEYKRIGKDGREIWLQATYNPILDMEGRPFKIVKYAVDVTAERL
RQADY-EGQIEAINKSQGVVELTLDGIILAVNDNFLSTLGFERDDVVGKHHSELEKSYAKSVEYSLFWETLRS-GQYHAGLYKRGNDGREIWIQASYNPI
LDLNGCPRKVIKYATSNVALAEAFEDAKRQAHLDSGTSLPNRTKLVAFMETALASA---AASMTVFYVDLDRFKPINDTHGHHVGDLVLGAVADRLRRAI
RADHMVARVGGDEFVIAAPGMPAEAVERFCMKLMETVGAPIRHESGELTVGMSIGVAIAPMDGTTPDELLRAADTALYRSKQSGRGQFSYFAAEMNDKIM
LQRKMTEDMRHSLTAGHFFLEYQPRFDTRARQMRSVEALVRWAHPERGRIPPCDFIPLAEQNGLIVPLGDWILDTACEAAANWSGIG-----VSVNVSPV
QFRDTKFVDKVRDCLRRSGLKGELLELEITEGVLLEDAERAIEVLNELKAMGVKLAMDDFGTGYSSLSYLRNFPFDVIKIDRSFISDLGTRESARPIVQA
ILGLGRALGLSVTAEGVETNEQLALLTADHCSEIQGFLMSRPLSQAKISELIEKV-----
>tr|L9PP19|L9PP19_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Janthinobacterium sp. HH01 GN=Jab_1c19770 PE=4 SV=1
----------------------------------------------------------TIWVIED---RTRAEESLRNALLENQAILDSAVLGIS-VVEQ
GRNLRCNTKMEELFGYAPGEMNQLS---V-QAFYADKDA-WEAARAADFHAGRVHASEYQLVRKDGSTFWGRLSGRPFDLAKATGRSVWLV-DDITERRE
----------------------------------------------------------------------------------------------------
---------------EIVERRQAEARVHHMAYHDSLTGLPNRALLSDRLDRAMLAAQRSERRLAVMFIDLDRFKTINDSLGHMTGDQLLKEVAGRLCRAV
RASDTVARLGGDEFVVLVPGIRSADASHVAEKIIEALSESFPLEGRNLHITPSIGICVYPDDGGDVETLMRHADAAMYHAKASGRNNYQYFKEAMNQTAA
QHFELESSLRSALVQDEFELHFQPIMDIGTRRLHTMEVLLRWRRGG-TLVLPDHFIPIIEENGLIVPVGEWVIRQACQQSMAWQRAGLAPVPLAVNLSPR
QFMHRGLIASIRGILDETGIDPSMIEFEITETALMQHGEQTLDILGQINAMGIRLSIDDFGTGYSSLAYLKRFPVKKIKIDRAFIKDLEDSAEDRAIVAA
IIALSDSLQLSVVAEGVETEGQYALLQRNGCQYAQGYLFSQPVPHETAQLLLPRL-----
>tr|W0VBB9|W0VBB9_9BURK Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628, complete genome OS=Janthinobacterium agaricidamnosum NBRC 102515 = DS
----------------------------------------------------------TIWIIED---RSRAEESLRNALLENQAILDSAVLGIA-VIEN
GFNLRCNTKMEELFGYGPGEIDGKS---V-RLLYPDLAA-WDAARLEDFRAGRVHMSEYQLVRKDGGTFWARLSGRPFDLAQANGRSVWLV-DDVTARRE
----------------------------------------------------------------------------------------------------
---------------EIVERRQAEARVHHMAYHDSLTGLPNRALLSDRLDRAMLAARRAERRLAVMFIDLDRFKTINDSLGHMTGDSLLKEVAGRLCRAV
RASDTVARLGGDEFVVLVPGIRKAAAGRVAEKIIEALAAAFPVEQHLLHITPSIGICVYPDDGEDVATLMRHADAAMYHAKASGRNNHQFFTQKMNQAAA
RHFELESCLRVALAQQQFELFYQPIIDTATRSLHAMEVLLRWRRPGHGLVLPDNFIPIIEENGLIVPIGEWVMRRACEQIMAWKRQGLVPVPLAVNLSPR
QFMHGGLVESIRRILEQTGVDPSLLEFEITETALMQQGAHTLEILDQINGMGIRLSIDDFGTGYSSLSYLKRFPVKKVKIDRAFIKDLEHSAEDRAIVAA
IIALADSLLLSAVAEGVETEQQFALLRQGGCRYAQGYLFSQPVPQDSAEQLLLRA-----
>tr|A0A031GSX7|A0A031GSX7_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Janthinobacterium lividum GN=BW37_02086 PE=4 SV=1
----------------------------------------------------------TIWIIED---RTRAEESLRNALLENQAILDSAVLGIS-VIEG
GYNLRANSKMEELFGYGPGEINGLS---V-QALYPDVAA-WKVARGEDFEAGRVHMSEYQLVRKDGSRFWARLSGRPFDLAHAHGRSVWLV-DDVTARRE
----------------------------------------------------------------------------------------------------
---------------EIAERRQAEARVHHMAYHDNLTGLPNRALLSDRLERSMLASQRSGRKLAVMFIDLDRFKTINDSLGHMTGDLLLKEVAARLCGAV
RASDTVARLGGDEFVVLVPGIRSGDAARVAEKIIEALTPAFPLDGHVLHVTPSIGICVYPDDGGDVDALMRHADAAMYHAKGNGRNNYQFFTQTMNQAAA
LHFDLESSLRTALALQQFELVYQPIIDIATRRLHGMEVLLRWRRPGHGLVLPDRFIPIMEENGLIVPVGEWVMRQACEQSMAWQRMGLQPVPLAVNLSPR
QFMHKGLVAAIGAVVRETGIDPAQLEFEITETALMQHGEHTLEILRQINGMGLRLSIDDFGTGYSSLAYLKRFPVKKVKIDRAFIKDLEHSAEDRAIVAA
IIALADSLQLSAVAEGVETEEQFALLQANGCRYAQGYLFSAPVPAANAQSLLERL-----
>tr|Q47FQ3|Q47FQ3_DECAR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (strain RCB) GN=Daro_1579 PE=4 SV=1
----------------------------------------------------------VFWIAED---RTQAEEELKKAYFDQRLIFDNCVAGIA-FVRN
RVFQQCNRRFEELYGYGPGELTGKP---T-RVTYFSDKA-HAEIGTTMLGRGETFVSEVVHRRQNGDPIWMRITGRAIDPANPNDGSIWNY-EDITSRKV
RESVM-LQR--------------------------------------------------------------VDQGQW----TFQRKDGEKFIVELSISAL
HPEDKKAQGFLFVASEVLERRRIESKLRYLAHHDALTGLANRTLLQQRLGEAMDNAAQDDTKVAILFIDLDRFKTINDSLGHHIGDTLLKNVASRLTETL
RSNDTIARLGGDEFMIILPLKANEAAGKLASKILDALRPPIRIDGHELFVTPSIGICFYPNDGVTVNALMRNADTAMYQAKANGRNTYCYFTAEMNAAAD
NYFQIESDLRRAVDRNEFEVFYQPVIDLKTHRITSYEALVRWRHPTKGLVGPAQFITVAEESGLIGEIGTIVLRQACSQLRSWIDEGFTSPILALNLSPI
QFNDPNLTEGICRILRDYDLTPDRIELEITETVIMQDGELALGTLQNLSSRGFRLSIDDFGTGYSSLAYLKRFPVDTLKIDRSFITDMTANENDRAIVTA
IMALANSLHLSVIAEGVETKEQYDLLSALNCNFAQGYYMAKPMPAEMISLETAAT-----
>tr|C7RK65|C7RK65_ACCPU Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Accumulibacter phosphatis (strain UW-1) GN=CAP2UW1_0299 PE=4 SV
----------------------------------------------------------YVWLFED---VTAAEEALVESLWEQQLIFDNAMIGIS-YHRN
RMILRCNRRCEEIFGYLEGGLAGQP---T-RVLFASDEA-WEAVGRQESASGETFDGELLYQRRDGTPIWVHAIGRTIGESADSETWIWAY-ADVTAQRA
RQSHL-ELETVFDSSAEGITITAPDGNIIAVNRAFTEITGYTEDEVIGRNPRMLQSGFQDRRFYLDMWQALGTQGRWRGELWNRRKDGQTFLESLTISAV
KDAQGKVAHYVG---DITELRRAHDQLDHQAHHDPLTGLPNRLLLGDRLHKALQRAHRDETGLAVFFIDLDRFKNINDTLGHQVGDRVLCEVAWRLGRLM
RESDTVGRLGGDEFLIVIEDVGEPTVSHIAEKILNVLQASPVTVEHEFFVGASIGISVFPQDGADAETLMKNADVAMYRAKERGRNTYEFFTKDLTQTSL
ARLQMETDLRRAIERGELRVYLQPQFSLATGKVVGAEALVRWLRPQQGLVLPGEFIKLAEESGLIVPIGEWVQGTAACQWATWVAAGLAPGVLSVNVSGV
EFARGRIQQTARRTLELSGLPARFLELEITESAIMSHAENSVQVLDNLRAMGISLVIDDFGTGYSSLAYLKRLPLNKLKVDQSFVRGLPNDTEDCAIARA
VIALGHSLQLTVIAEGVETEAQREFLTGEGCDEMQGYLRGRPMPFDDYHARFLSG-----
>tr|A0A084XUT8|A0A084XUT8_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-01 GN=gmr_13 PE=4 SV=1
----------------------------------------------------------HVWLYED---VTAAEEALVESLWEQQLIFDNAMIGIS-YQRE
RTFLRCNRRCEEIFGYPPGGLQGLS---T-RILFASQEA-WEEAGRLNAATGGTFDGELLYCRRDGTPIWVHVIGRIIGDHQEGETWIWTF-EDVTAQRA
RQSHL-ELETVFDSSAEGITITAPDGCIIAVNRAFTEITGYREDEVIGSNPRILQSGLQDAAFYREMWQVLGHCGRWRGELWNRRKDGQIFLESLTISAV
HDPDGQLTHYVG---DITALRQAHDQLAHQAHHDPLTGLPNRLLLGDRLHKALQRAHRDETGLAVLFIDLDRFKNINDTLGHQVGDRVLCEVARRLSRLM
READTVGRLGGDEFLIIIEDIADPAVSYIAEKILNTLQNSPVTVEQEFYIGASIGISLFPDDGADPETLMKNADVAMYRAKERGRNAYEFFTKVLTQSSL
ARLQMETDLRHAVERDELLVYLQPQFSLKTGKVLGAEALVRWLRPEHGLVMPSEFIRLAEESGLIVQIGEWVQQTAGGQWAAWIAAGRRPGVLSVNVSGV
EFVRGRIQETARKTLETSQLPAQFLELEITESAIMSHAENSAQTLDKLQSMGLSLAIDDFGTGYSSLAYLKRLPLNKLKIDQSFVLGLPGDTEDCAIVRA
VIALAHSLQLTVIAEGVESEAQQEFLTRAGCDEMQGYLHGQPMPFDEYERCFLND-----
>tr|A0A011RJH5|A0A011RJH5_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-93 GN=gmr_1 PE=4 SV=1
----------------------------------------------------------HVWLFQD---ITAAEEALVESLWEQQLIFDNAMIGIS-YQRE
RTIWRCNRRFEEIFGYPVGAMTGQS---T-RILFATEKD-WEDAGREDAT-SGSFDGEFLFSRRDGTPIWVHIIGRTIDDGDARQTWIWTH-EDVTAHRA
RQSHL-ELETVFDSSAEGITITSPNGEIIAVNRAFTEITGYSEDDVVGGNPRLLQSGFQDPEFYREMWRTLHTCGRWRGELWNRRKDGQAFLESLTISAV
KDPQDRVTHYVG---DITELRKAHDQLDHQAHHDPLTGLPNRLLLGDRLHKALQRAHRDERGLAVLFVDLDRFKNINDTLGHQVGDRVLCEVARRLTRLR
READTVGRLGGDEFLIIIEDLGDAAVSHIAERILALLQDSPVTVEHEFYVGASIGISLFPQDGGDAETLMKNADVAMYRAKERGRNTYEFFTKELTQSSL
ARLQMETDLRRAIDRGELRVFLQPQFSLTGGELVGAEALVRWLRPERGLVMPGEFIRLAEESGLIVPIGEWVQHTAACQWAAWLGAGLKPGVLSVNVSGV
EFQRGRIQETACKTLESSQLPAQFLELEITESAIMTQAESSVQVLDALRAMGLGLVIDDFGTGYSSLAYLKRLPLNKLKIDQSFVRGLPGDAEDRAITRA
VIALAHSLQLTVIAEGVESEAQRDFLAGEGCDEMQGYLRGRPMPLDDYRQRFLEG-----
>tr|W0SLR4|W0SLR4_9RHOO PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_02944 PE=4 SV=1
----------------------------------------------------------WIWTYED---ITAAEAALAENAREYALIFDNALIGIA-YMRS
RTFLRCNRHLEAIFGFPPGGLTGCT---S-RVLFASDED-WEAAGRRITREGRDFSGEILYQKQDGTPIWARVNGQPIQEG-DGQVWIWTM-QDITRRRQ
RQSYN-EMETVFDSSAEGITITAPDGSIIAVNRAFTEITGYGESEVLGRNPRILKSDRQDRDFYRRMWETLHQTGRWEGELWNRRKDGGIYPERLTISAV
KDPDGSVMHYVG---DITEIKRATDLLDHQAHHDHLTGLPNRLLLEDRLRGALLRAQREQMQVAVLFVDLDRFKNINDSLGHHVGDGVLCEVARRFRALT
RESDTVARLGGDEFLIVMEGIHDPAASRIADKIIDDLRTNPVTLEQEFFVGASIGISLFPQDGDNSSTLLKNADAAMYRAKERGRDTYEFFSDDLTQFSL
DRFKMETDLRRAIERDELIVYLQPQFSLWTGELLGAEALVRWQHPRLGLVAPASFIPLAEESGLIVALGAWVQQAACLHWAAWAVAGLNPGVLSINVSGV
EFRLGRIQDTVRGVLKATGLPAALLELEITEGAIMNQAENSIQVLHELRATGIGLAIDDFGTGYSSLAYLKRLPLNRLKVDQSFVRGLPDDPEDCAIVRA
VIALGHSLQLKVIAEGVETQDQVEFLAREGCDEMQGYLRGKPLPVEDFRREFLGN-----
>tr|A0A011NT85|A0A011NT85_9PROT Bacteriophytochrome cph2 OS=Candidatus Accumulibacter sp. SK-12 GN=cph2_3 PE=4 SV=1
----------------------------------------------------------LVWLFED---VTAAEEALVDSLWEQQLIFDNAMIGIS-YQRQ
QTILRCNRRCEEIFGYPPGGLKGQS---A-RILFASDEA-WEADGRLHHP-RETFVGEFVYCRRDRQPIRVRAIGRTIGEDEKAGTWIWTY-EDVTAQRA
RQSHL-ELETVFDSSAEGITITAPDGRIIAVNRAFSEITGYSEEEVIGRNPRILQSGRQDRGLYQQMWQTLTACGHWQGELWNRRKDGKTFLESLTISAV
KDSEGSLTHYVG---DITELRRAHDQLAHQAHHDPLTGLPNRLLLGDRLHKALQRAQRDGSELAVLFIDLDRFKIINDTLGHQAGDRVLCEVARRLSRLM
RESDTVGRLGGDEFLIIVERIVEPGASLVAEKILVVLQDAPVTVGQEFFVGASIGISVFPQDGNDVETLMKNADVAMYRAKERGRNTYDFFTKALAGSSL
ERLQMETDLRRAIERGDLRVYLQPQFSLHDGRLLGAEALVRWSRPAHGLVMPGEFIRLAEESGLIVAIGEWVLLTAARHWADWLAAGLAPGVLSINVSGV
EFSRGGIEQTARKAIATSGLAASCIELEITESAIMSHAEGSVQVLDNLRAMGISLVIDDFGTGYSSLAYLKRLPINKLKIDQSFVRGLPADVEDCAITRA
VIALAHSLQLTVIAEGVESDLQRDFLADAGCDEMQGYLCGRPLPIDEYRQRFLDH-----
>tr|A0A011PYJ1|A0A011PYJ1_9PROT Bacteriophytochrome cph2 OS=Candidatus Accumulibacter sp. BA-94 GN=cph2_1 PE=4 SV=1
----------------------------------------------------------LVWLFED---VTAAEEALVDSLWEQQLIFDNAMIGIS-YQRQ
RAILRCNRRCEEIFGYPPGGLNGQS---A-RILFASDEA-WEEGGRLHHP-RETFAGEFVYCRRDGQPIRVRAIGRTIGEHEKADTWIWTY-EDVTAQRE
RQSHL-ELETVFDSSAEGITITAPDGCIIAVNRAFSAITGYSEDEVIGRNPRMLQSGRQDREIYQQMWQALATVGRWQGELWNRRKDGQTFLESLTISAV
NDGEGRVTHYVG---DITELRRAHDQLDHQAHHDPLTGLPNRLLLGDRLHKAMQRAHRDETELAVLFIDLDRFKIINDTLGHQAGDRVLCEVAWRLRRLM
RESDTVGRLGGDEFLIIVERIADPGASHVAEKILTVLQDAPVTVEQEFFVGASIGISVFPQDGGDVETLMKNADVAMYRAKERGRNTYDFFTKALTGSSL
ERLQMETDLRRAIERDELRVYLQPQFSLLDGHLLGAEALVRWWRPEHGLVMPGEFIRLAEESGLIVAIGEWVLLTAANHWAAWLAADLAPGVLSVNVSGV
EFSRGGIEQTARRAMSSSGLAARCIELEITESAIMSHAEGSVRVLDNLRAMGISLVIDDFGTGYSSLAYLKRLPINKLKIDQSFVRGLPGDVEDCAITRT
ARSPGR------------------------------------------------------
>tr|E8LSZ5|E8LSZ5_9VIBR GGEF/EAL/PAS/PAC-domain-containing protein OS=Vibrio brasiliensis LMG 20546 GN=VIBR0546_00445 PE=4 SV=1
----------------------------------------------------------------------------------------LTQSGSWTWDIS
QNHFSYSKNLAKMVGITENQQLHFA-DFFRSYIFKSKI-SLDRFVSDVSSEAKTVTVEMCA-----INKQFEI-SYIKFTPSGELRKVVGNIRNTTDISQ
LEADFTIAQKVVDLSSNGVLITDKHNRIISTNSKVEDITGYSFAELEGQSPSILSSSLHPASFYQKMWAELHEQGHWSGEVWNQTKFGAVYPEKLTIYVL
RNRVGEIQNYIATFEDLSEIKSIESELNNYKNEHDFTGLQTRENFIKALQE--------TDNQTVLILDIKRFSSINNMYGESFGNKVLVHVGHTLATND
TKQINICRYGPDQFALSFSQDSLEGVNKFVSFVRSQIETAVTIDDHEIDLLVNIGCSNMSEFDKTH--PIKQAYYALRQAKSDPTPSTSIYSSQLEKRVA
RQYALGARLKKAIDEKRIDVFYQPILDLNSEKVVKLEALARWTEDG-EMISPFEFIPIAEKLGYIFQLGEIILEKSCQDLKKLKALGHDNIAISINRSID
ELSEEQANCSILNIIRNSGLSEKDIIIEVTESIPLEDKPHVQELLRVLRSKGVKVALDDFGTGYASFSNLMKNSIDILKIDRSFVKDISTNQNNAVLIKS
VNLLADQLGLDVIAEGVEDYQQLNLLQELGCRYIQGYLISKPQPFDDIVLEVERIN----
>tr|C9QKQ6|C9QKQ6_VIBOR GGDEF/EAL domain-containing protein OS=Vibrio orientalis CIP 102891 = ATCC 33934 GN=VIOR3934_21596 PE=4 SV=1
----------------------------------------------------------------------------------------ITQSCSWRWDVE
KDKFKYSNNLGVMFDLNTDVKLSFY-EFFNQYVFKSHE-QYKQLLTSECAQVVTTIIEESK-----CHIDLEI-TYSKFGPNGALTRIEGNVRNISDLSE
LVNDHLIAQRVIELSSSGVILTDANNLILNMNSKAEDITGYRLDEMYGLPPSTFSSDIHDRKFYKTMWQSIELSDCWSGEVWNKTKSGAIYPEQLSIHVV
RGRKGDIQNYIAIFDDLSYKKSIENELLKYRNKQDFTGLMTRTKFIQMLED--------NPEFAVLLVDISRFSEINNLYGEEFGNKVLSYVGQILYANS
AEKLNICRYGADQFALAWNLANVSGVEQLVSTIRATVEEAFSIDGTTMNLAVNMGYSLPIESTETH--PLTKAYYALEEAKSQLTPGTIRYSDYLEQRAE
RKHQLGAMLKQALDEERLHVEYQPIYDLQTRTIVKFEALARWVEGN-QSISPFEFIPIAEELGYISQLGNLILKKVCKDILSMKALGFDEIVISVNRSIE
ELLNEIDNCSILSQLEESGLSTRDVIIEITESIPLEDKPQVQDLLDCLRKRGLKLALDDFGTGFASFSNLMKNTVDLLKIDRSFIRDIESDKNNAVLVES
VNMLASQLGLEVIAEGVETKQQLELLQSMGCRYIQGYYISKPVPFDKAMTLLEKYS----
>tr|X0NMW3|X0NMW3_PHOLE Sensory box protein OS=Photobacterium leiognathi lrivu.4.1 GN=PLEI_0965 PE=4 SV=1
----------------------------------------------------------------------------------------VAKLGNWQWDVL
TNTYTWSKEACRIYELE-NCLHPDL-KFVHSSIHPEDRERVITFMNNIITNGKTTLLEERVIHSDSQSLCFDFRGSVVVNAFGDTEKVAGVLTDITDSVS
TVQQLNLAKTVFDNTSECIVITDSNNHIVTVNQSFEAVTGYSSEEVIGKDPRILASGFHGKTFYEEMWDCVEHTGQWKGQLYNRRKNGNVYPEEMTINKV
EDDNHEVVNYVGVFHDISVRQQTEKELLFYANNDALTTLMNRRCFTERVEQEINSKGGCNQEFSVLFIDLDDFKSINDLYGHDVGDKLLKHIAEILLDFC
SKETLVCRYGGDEFAILLKGKSSAFAKQYARKLMRALSVPILIDALQFNVTISIGISTYPESGVTHQALLKNADYAMYEQKRNGRNGISIYDAQLQSEYI
RKLRLKDRLIKAIAEKKIQVYYQPIVDIETGKICKFEALTRWFDEEEGYISPVIFIEMAETYGLIGQLGRVVFEQACRDLAYMHNQGYDDICMSINRSVR
EFALYDQ-KYIYDIIDEHGLAYNKIMIEITESAALDEGNNILELLSEFAQKGICVAIDDFGTGYSSMSAIIANKPNVIKIDRNFIVDIEQSVESQILVSL
VMDMSRKLHLDVVAEGVETKAQLQLLSKMGCHYIQGFYFSPAVNIDAAMVLLKQSN----
>tr|A0A0B7JBV2|A0A0B7JBV2_PHOPO ANT-220, BDW_PPBDW_I_Contig_2, whole genome shotgun sequence OS=Photobacterium phosphoreum GN=PPBDW_I20898 PE=4 SV=1
----------------------------------------------------------------------------------------EAKLGNWQLDLV
INCYYWSREIYRIFQCDIDTFVPNN-DVINDFIHPDDRVRVSELKDEMINNGVATLLSKSSVNNDAISIDVEFRGNIISNNSNRSDSIVGVLIDITATVL
AAQKLTLAKTVFDNTSECIVITDQDNNIISVNKAFETVTGYNQADIIGKNPRILASGYHNLEFYQQMWHSLETTGAWQGQLHNRRSDGVIYPEEMTINKI
EDD-HNVINYVGVFHDISSRKQTEKKLRLLADNDMLTGLMNRRRFIEKVEKQIAKDISSTSVCSLLFIDLDDFKIFNDLYGHDFGDNVLKEVASILRDTV
CEHSIICRYGGDEYAVLIKGKDVNYAQNIAAKLVDIISKPIKCNDIEINLTISIGISSYPESGTTHQALLKNADYAMYEQKWLGRNGVCVYDQQLQHEYI
RKLKLRDKLKHAIKDKKISVYYQPIIDNKTGTVCKFEALARWYDEHDGFIPPSVFIPIAERYGLIGMLGQQVFEKACADLDRIHRCGFRDVIFSINHSVK
EFSQHNQ-EYIFEIINNYNLPYSAIMIEITESTALDDGKNILEILAAFRERGIAISLDDFGTGYSSLAAIIDIKPDIIKIDRSFIVDIEHSKESQMLVSL
VIDLSCKLNVEVVAEGVETQAQLDILSSMSCHYIQGYYYSPAVAIDDAIMILKARN----
>tr|L8JJS4|L8JJS4_9GAMM Diguanylate cyclase OS=Photobacterium sp. AK15 GN=C942_01607 PE=4 SV=1
----------------------------------------------------------------------------------------VAKVGSWYWDLT
TDIITWSQEVYRIYGIDDSSITPSI-DFLSKLIHPEDRDWVLSSLYGSIENGNPLQLEKPCRGNQNRVFQFEFRGNIIKNADGKPARVAGIQRDITNSVE
AKRQLNRAQVVFDNTSECILITDKHNRIISVNRAFEQTTGYREKELLGLTPKVLSSGIHDQEYYKSLWYSLETKGHWKGEVWNKRKNGEMYPEEMSINVI
RDSNDEIVNYVAVFRDISHWKQAEEQLTFFAFYDPLTGLVNRRSFVHRVEQHINMVQKENSVFSLLFIDMDDFKSVNDLYGHDFGDRLLTQIAERLKSIF
EEKDNICRYGGDEFCILLPNLTAADAREKAQEIVSVISQPLEIDGVVINTTVSIGISAFPESGLTHHALLKNADYAMYYMKGQGRNGVCEYDGKLQSEYI
QKLKLRDRLKNAIAEGSLTVNYQPIVHAQTGQVNKFEALVRWKDEVYGDIPPSRFIPIAEKYGLIKPVGSFVLHQACRDLKALHDAGYTNVSFSINRSVK
EFINHNDDPAIWEITQQYGLPDKSIIIEITESTASKESSDIQSLLGFFKKRQMQVALDDFGTGYSSLSAVVDLRPDIIKIDRGFIKEICRSQDSLTLVSL
IIDLSHKLGIKVIAEGVETEAQLHILQKLQCKYVQGFYFSKALPFDQCLTYLSQSY----
>tr|A0A0C5WRP4|A0A0C5WRP4_9GAMM Putative diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Photobacterium gaetbulicola Gung47 GN=H744_2c2374 PE=4
----------------------------------------------------------------------------------------VAKVGSWVWKLQ
EQHFEWSKEVYRIYDFKDESVKPTL-SLLSELIHPEDREWVLDTLHRSIESGKAVELEKPIAGNHASVFQFEFRGSIVRDENGRPTKVAGIQRDITHSVE
AKRQLDRAQVVFDNTSECILITDKDNKIISVNRAFEETTGYREKELLGLSPNVLSSGIHDDKYYQFLWHNLNHYGHWKGEVWNRRKNGEIYPEEISINVI
RDDNEEIINYVAVFRDISHWKKAEEQLTFFAYKDPLTGLVNRRSFVKRVKQHIASDDKRGQAFSLLFIDMDDFKSLNDLYGHDFGDKVLVHIASCLKREL
PVADDICRYGGDEFCVLLPETTSGAARVWGQRVVDSVAEAFVLDDIEVNTTVSIGISTYPESGETHTELLKNADYAMYNMKGQGRNGVCQYDGALQSDYI
DKLKMRDRLKKAISDELLTVYYQPVVDARTGKISRFEALVRWTDEVEGNISPAEFIPVAERYGLIRSLGDFVLHQVCHDLKQLHLAGFADVSISINRSVK
EFISSNGLPPIWDTIESYALPLKSIIVEITESTASSESSDIQSLLASFKQKGIEIALDDFGTGYSSLSSVVELRPNIIKIDRSFIEGIDK-QDNRTLVSL
IIDLSHKLGIQVVAEGVETRKQLEILREMNCHFVQGFFYSPAVPLASCISILEAQL----
>tr|U1KS09|U1KS09_9GAMM PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudoalteromonas rubra ATCC 29570 GN=PRUB_12356 PE=4 SV=1
----------------------------------------------------------------------------------------IAKLSSWSWNIS
RDKHIFSHEMRRLLQHREETL--TL-DDFTNCLTEADQKRLRVIIQKLRTHKKRTNI-----------------GRVECDEQRDERVFSATVQDVSYIYS
LNKQLELTNVVFEHATEAIMITDGENKIIMVNRAFERLTGYTGHELMGRDPSVLSSGQHGDDFYHQMWNSLMSAGCWKGEIFNRRKNGQIFPEELTLSLV
KDEQGEIVNYVAIFRDITEWKRNEAQLMFYANHEPLTALLNRRCFIDIVEEKISASRSLHTPCSLLFIGLDHFKEVNDIYGPEIGDKVLVSVAKRLRNGI
RENDTISRYGGDEFAILLDNTDVKSALQVAKKLSDKIKQPYVFNDLTVELSASTGIAQLENRGITAAKFIRNAAHALESAKKTHRGHVALHNAAIQNAYL
NKIKLKDKLKAALKANLLTVYYQPIVDVQRGKIVKFEALVRWFDDEQGMVSPGTFIPIAEEFGLIHLIGQFVLDQACQDLKAIHSHGYDEVSISINRSVN
EFKTSDQFKLVTEAIEKAQVPYDKVTLEVTESMATNR--YTWELLSKLRAQGVKIALDDFCTGYSSLSHLVENQVDYLKIDKSFVDSLMADRNKKVMISC
LLNLAQELGIKVIAEGVESQSQLAMLEQLGCNHIQGFYYSPAQPLSACLRLLQEFN----
>tr|V4HV73|V4HV73_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain protein OS=Pseudoalteromonas luteoviolacea 2ta16 GN=PL2TA16_02902 PE=4 SV=1
----------------------------------------------------------------------------------------IARLSSWSWNIS
RNIHSFSQEMQTLINLPDQDI--GF-ELFCDSLKEKDQKSLRVLMQKIRNHSDRSQI-----------------GHVESDEQEDERIFCASVQDISYIYA
LNKQLELTNVVFEHATEAIMITDHKNRVVMVNRAFERLTGYSDTELLGRNPSVLSSGKHSAEFYDKMWTKLCKEGTWKGEIYNRRKNGQIFPEELTLNIV
RDEEGDIVNYVAIFRDITDWKRNEAQLTFYANHEPLTALINRRCFMDILETRISQSRSTLQPCSLLFIGLDHFKEVNDIYGPEIGDKVLISVAKRLKNGL
RRADTISRYGGDEFAILLDATNQQSAHDIASKLCDKLKQPYVFNELTIELTASVGVAQLDCQSVTAAKFIRNAAHALESAKKTNRGSVALHNQAIQNAYL
NKIALRDKLRHAIKYELLSVYYQPIVDQSSGRIVKFEALVRWFDEEQGMISPGAFIPIAEEFGLIQQIGQFVLERACMDLKKVQSVGYTDISISVNRSVN
EFKVSNQFDLISEAIEKYDIPYSSITVEVTESMATNH--YTWQLLRDLRGKGVKIALDDFCTGYSSLSHLIENQVDYLKIDKSFVDSLLQDKSKQIMISC
LVEMAKQLGIKVIAEGVESETQLNVLNDLGCDHIQGYYYSPARPVGACIQLLEEFN----
>tr|A0A0C1LNQ5|A0A0C1LNQ5_9GAMM Diguanylate cyclase OS=Pseudoalteromonas elyakovii GN=QT15_14140 PE=4 SV=1
----------------------------------------------------------------------------------------IADLCTWTWQLK
QNKHYFSSHLNHLLKTKTDSLSLSL-SLLLDKLTIEDSERLRIALEKVKLLTSRTEI-----------------GQVEDEQHSDELVFTATIQDISYISS
LNKQLELTNVVFEHATEAIMITNNENKIIMVNRAFERLTGYTGYELLGQDPAVLSSGKQDKSFYEAMWASLSTVGHWKGEIHNRRKNGQIYPEELTLSVV
KDEQGKVANYVGIFRDITEWKRNESQLTFYANHEPLTALLNRRSFMQRLEEQISASRSNNTSCSLLFIGLDRFKEVNDVFGPEIGDKVLISVAKRLKNAV
RQNDVIARYGGDEFALLLTHSDVESALKIAQKLSQKLSQPYVFNEITIEVTCSTGIAQLEAGSITAANLLRNAAHALNSVKKTERGQVALHNAAIQNAYL
NKIKLKDKLKQALKEGALTVYYQPIVNADTNHITKFEALVRWFDDEYGMVSPGTFIPIAEEFGLIHLVGQFVLERSCQDLAKIHQAGFTEVGISINRSVS
EFKASNQVKLITSAIEKAKIPYEAITIEVTESLATNR--YTWKTLNQLREHGVKVSLDDFCTGYSSLSNLIENQVDYLKIDKSFVDSLMSDYNKQVMIDC
LIKLSDKLGIGVIAEGVEQFTQLEKLRELGCHHIQGFFYSPAKPIDACLELLTTDA----
>tr|L8D8Y0|L8D8Y0_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudoalteromonas luteoviolacea B = ATCC 
----------------------------------------------------------------------------------------IAQLCSWSWNLK
SDMHWFSVEMPRLMQQPQTAP--TL-STLIENLTPCDKQKITRLMDDLKQHKSRTLV-----------------GEVELE--GNERCFNATIQDVSYISS
LNEQLELTNVVFENASEAIMICNAQNQIIMVNKTFEQTTGYSAIELIGKDPKVLSSGLQDHAFYSQMWRSLDDTGRWKGEIFNRRKNGQIYPEELTLTVV
RNEAGEISNFVAIFRDITEWKRNEAQLMFYANHEPLTGLLNRRSFMDKLESKISECRSLYTPSSLIFLGLDRFKEVNDVFGPEIGDKILNSVAKRLRNSV
REQDLVCRYGGDEFVILINKSSEEEAYSVACKLSAKLRQPYVFGELTVELSASIGVAQLEEKVISAANLIRNAAHALTSAKKSNPGSVAVHNHQIQSAYL
QKIYLKQKLKQAVKDKQLKVYYQPIVDIACGKIIKLEALVRWFDDEHCAIGPNVFIPLAEEFGFIHLVGQFVLEQSCKDLLMFKSHGFDDISISVNRSVN
EFKVSNQLELVLKALNEANIEAKYLTLEVTESIATNS--YTWDVLEELRKAGVTIALDDFCTGFSSLSNLIEHQVDFLKIDKTFVDSLIADKSKQVMISG
LIQIASKLGIKVIAEGVETQAQLDLLADFGCHYVQGYYFSPAKPASACLDMLKGQI----
>tr|U1KXF6|U1KXF6_9GAMM PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudoalteromonas citrea NCIMB 1889 GN=PCIT_00808 PE=4 SV=1
----------------------------------------------------------------------------------------IAKLSSWTWRIK
QNSHWFSAEMTRLIKGAAQDI--SI-VDFMNSLEESDKYKLQGLLDKVAAHIKRTEI-----------------GRVESEAPESERIFSATVQDVSYISA
LNKQLELTNVVFEHATESIMITDAHNKIIMVNRAFERLTGYTGYELLGKDPAILSSGHQDTQFYNQMWRQLNKEGMWKGEIYNRRKSGQVFPEELTLSLI
KDEEGSVCNYVAIFRDITDWKRNEAQLTFYADHEPLTGLQNRRSFLKALEVKVSESRAQHRLCSLLFIGLDRFKEINDVFGPEAGDKVLLSAAKRLKNAV
RAQDTVSRYGGDEFAILLDHTDGDNSMLVAKKLSAKLAQPYVFNDLTIEITASTGVAVLPIEQITAANLVRNAAHALGSAKKHRVGSVALHNAAIQNAYL
NKIKLRDKLKEALKSKLLEVHYQPIVDAKTGKIRKFEALIRWFDEEYGVVSPGRFIPVAEEFGLIHYIGQFVLEQSCEDLSKIHQAGFTDVSISINRSVN
EFKSTNQIELISAAIEKANLPYNAVTIEVTESMATNK--YTWHVLSILRSKGVKVALDDFCTGYSSLSNLIDNQVDYVKIDKSFVDSLVADKSKQAMIKC
LVDLSSQLNIRVIAEGVEQSVQLEMLQQYGCHNIQGFYYSCAKPIKECLNMLYSSK----
>tr|Q2SFI2|Q2SFI2_HAHCH FOG: EAL domain OS=Hahella chejuensis (strain KCTC 2396) GN=HCH_03865 PE=4 SV=1
----------------------------------------------------------------------------------------IARLGNWVWDLK
RNEVYWSDQVYRNLGLSLHDNKASY-EKFLECVHPDDRARIVKLVDEALEQGNPVQDETA-LRWALSNLELNIRTSTAQSEDGEFRGSRCILVDYTERRR
HEKELQQAAVVFDAIREAVIITDDARNIVAVNNAFTDITGYTLDDVYGRNPRLQQSGRHDKTFYRSLWRSITEHGHWQGEIENKRRNGEIYPAWQNINVV
YDKNGNVANYVSVFSDISVIKEKEKQLRHLANHDSLTGLPNRLLFFNSLENSLERARRRRMEVALMFIDLDRFKIINDTMGHEAGDILLKTVARRLLEAV
RGEDMVARLGGDEFTISLEELNTEDAAAKAGKLIETIRQPVHIGGHEIVCSASIGIAIFPHDADNAQNLARAADAAMYRAKELHRNTFEFYTSELTERAI
EHLTLSSEMRQALERNEFELYYQPQFNLTSGRLVGAETLLRWRHPTRGLITPYCFINIAEDSALIDPIGGWVINQLCRDVAGWLKGGLKLPRIAFNVSSK
QLEHYDVKGRIEHALQRWGLEPSDLELEVTEGALQHE-ERSVEVLRQVRLLGLSVAIDDFGTGYSSLSRLKHMPIDTLKIDRMFIRDLPDDPNNQALASG
IILLGRALGLKVVAEGVENVEQLRFLQERNCDEAQGFLLSKPLPKAAFEKMLKGEG----
>tr|W8G723|W8G723_9GAMM Diguanylate cyclase OS=Thalassolituus oleivorans R6-15 GN=R615_04215 PE=4 SV=1
----------------------------------------------------------------------------------------LPQLL-------
--NSYWRNDLNTERHYEMGGSKVLR-R---AAAIPAD-VELLNL------TQPPLSFEETLTTVKPSDMIYRIVRAEVVDDSGKLVGRVGSIQDITEQQA
KEHRLRQAMTVFESTMEGVVITDSQNRVEAINPAFTSITGFEEADVLGRSISLLNSGRHSKTFYEGIARSVQERGYWRGEIWNRRKNGQIYPQWLTITEV
KDAQNRVTNYVGVFSDMSRIKESEEQLEHLSNYDSLTNLPNRALLLSRLEGAVNVATQKGRKVGVIAIDLDHFKHINDSLGHPAGDRLLQEFAQRMRQRL
RDSDTVARQGGDDFVVVLENVSHEQVSNVADIILNLLRTPFDVGGQELYIGASLGITLFPDHGSDVTQLLSNADVAMYQAKQRGRNHYQFYSNDMTQAVS
DRLELGNQLRGALQDNELQLYYQPQVCLIDGHIVGVEALMRWHHPQEGIIAPGRFLPVAEDNGLMPELDGWALRVACHQIAVWQNEGFEPMIVAVNISQP
TFVAGGLVERLRRLLDETQIDPSWLELEITEGALLEPSTQVLDTINGLKELGVMLAVDDFGTGYSSLAYLHRYRVDKLKIDRSFVQSVEDEDEGRVITTT
IIHMAKGLGLQVLAEGVETEAQLNFLRDNGCESYQGFYFSKPVPVAELKLEKTKDH----
>tr|K9FA99|K9FA99_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Leptolyngbya sp. PCC 7375 GN=Lepto7375DRAFT_2108 PE=4
--------------------------------------------------------------------RRESEEKLQKSEERFSLAMRGANDGLWDWNLE
TNEVYYSPRWKSMLGYQNDELTNDLNAWQ-SLVHPDDKDRV-LKMVQDYLVGESFDIEMRMQHKAGHEIFVLSRAFLVRNSDGKAVRLVGTHVDITARKK
TEVFDDKNAEILEMIATGKPASEIYPEIALMYEARHPGLRCSMLELQDGRLMHGGAPSLPKEYCALPHGMRCCWSEPIKNSSGMVLGAFGMYYDHPALPN
EEESNDLKSAARLAGIVMERDQAQKRIRELAYTDELTGLASRASFYQNLEASIQRSDRNISRLGLLYIDLDNFKSVNDSLGHDAGDLLLQEIAKRLQAVT
REIDFVARLGGDEFCILVHDVEDYAAAHMAQRCLDVISKPVELSARKFTPACSIGIAHYPNDGKDLSTLIKAADTSLYAAKERGKNQYAFYKSKLTQKAE
YQFRVEQNLREAVEKQQLSLVYQPQIQILTGNIIGVEALSRWNHPQLGQISPIEFIATAERIGMIKPLTEWVLTTACNQAVAWKKAGLPAIRMAVNISPI
HFLDKDFVSLIKRVIDETGMVPSELELEVTESVVQTDQQN-LSIFRELKDLGVLLAIDDFGTGYSSFASLKHLTVDCLKIDKYFINDMLINNKSRVLIGS
MIEMCRNLEHKIIVEGVETAEQYYTLQKFGCETAQGYLFSKPVSSAEISKLLNRN-----
>tr|U9WAH3|U9WAH3_9CYAN Diguanylate cyclase OS=Leptolyngbya sp. Heron Island J GN=N836_04635 PE=4 SV=1
--------------------------------------------------------------------RRESEEKLQKSEERFSLAMRGANDGLWDWNLE
TNEVYYSPRWKSMLGYENNELVHDLSTWQ-RLVHPEDKDKV-LKMVQDYLVGDSFDIEMRMQHKAGHEVFVLSRAFLVRDSDKKAVRLVGTHVDITARKK
AEAFDDKNAEILEMIATGRPASEIYTEIALMYETRHPGLRCSMLELKDGRLMHGGAPSMPKEYCALPHGMRCCWSEPIKHSSGMVLGAFGMYYNHPALPN
EEESNDLKSAARLAGIVMERDQAQKRIRELAYIDDLTGIANRANFYQVLEASIKRSNRNTSRLGLLYIDLDNFKSVNDSLGHDAGDLLLQEIAKRLQKVT
RETDFVARLSGDEFCILVNDVNNYSTAHVAHSCLEVISNPVELLARKFTPACSIGIVHYPDDGTDLSTLIKAADTSLYAAKERGKNQYTFYKPELTQEAE
YRFRVEQNLREAIEKQQLSLVYQPQVQILTGNIIGVEALSRWNHPRLGQISPDEFITTAERIGMIKLLTEWVLTTACSQAVAWKKAGLPAIRMAVNISPI
HFLDKSLVSLIKHVIDETGILPSELELEVTESVVQTDEQN-LSIFQDLKDLGVSLAIDDFGIGYSSFASLKHLKVDCLKIDKYFINDMLVDHKSKSLIGS
MIEMCRNLEHEVIAEGVETVEQCNMLQQFGCETAQGFLFSKPVSSDEISKLLNSN-----
>tr|B0C439|B0C439_ACAM1 Diguanylate cyclase/phosphodiesterase with PAS domain OS=Acaryochloris marina (strain MBIC 11017) GN=AM1_1262 PE=4 SV=1
--------------------------------------------------------------------RRESEEKLQQSEERFLLAMRGANDGLWDWNLE
TDEVYYSPRWKSMLGYENDELAHDLSTWE-NLVHPDDKKKA-LALVEDYLDGDAFDVEMRMQHKAGHEIYVLSRAFLVRATDGKAVRLVGTHVDITARKK
AEAFDDKNAEILEMIATGKPATKIYDEIALMYESRHPGMRCSMLELQDGRLMHGGAPSLPKEYCALPHGMRCCWSEPIKNSSGIVLGAFGMYYNHPALPN
ELESNDLKSAARLAGIVMERDQAQKKIRELAFNDSLTGLASRAHFYQNLEVAIKRSDRNASRLGLLYIDLDNFKGVNDSLGHDAGDLLLREIGHRLQRVA
RDIDFVARLSGDEFCILVTDVDDYAASTVAQRCLEEVSQSIELSARKFTPACSIGIAHYPDDGRELSTLIKAADTSLYAAKERGKNRYAFYQPQLTEQAE
YRFRVEQNLREAVEKQQLSLVYQPQVELFSGNIIGVEALCRWHHPQLGEVLPTEFIATAERIGMMKPLTEWVLKAACNQAVAWKRAGLPPIRMAVNISPA
QFLDKYFVSLIQYVLEETGMVPTELKLEVTESVVQTDQQN-LSIFRELKDLGVLLAIDDFGKGYSSFASLKHLTVDCLKIDKYFIDDMLVDRKSQTLIAA
MIDMGHNLDHEIIAEGVETVEQYQMLQQFGCETAQGYLLSKPVSPDSISKILKLN-----
>tr|L8LZX7|L8LZX7_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Xenococcus sp. PCC 7305 GN=Xen7305DRAFT_00014310 PE=4
--------------------------------------------------------------------RRESEKKLRQSEERFSLAMRGANDGLWDWNLE
TDEIYYSPRWKSMLGYENDELDDNFSTWE-SLVHPNDKDIV-LTKVQDYLIGDSFEVEMRMLHKDGHEVFVLSRAFLVRESDRKAVRLVGTHVDITERKK
AEAFDNKNAEIMEMIATGQPASAIYNEIALMYEKLHPGLRCSMLELQDGKLMHGGAPSLPKEYCALPHGMRCCWSEPIKSSAGKVLGAFGMYYNHPALPN
EEESNSLKSAARLAGIVMERDHAQKRIRQLAYTDELTGLASRAHFYQNLEELIKVCDRHQGRFGLLYIDLDDFKSVNDSLGHDIGDVLLKEIAKRLDNVS
RDIDLVTRLSGDEFSILVRDVDDYAAAHVAQRCLETISEPIELSGRKFTPACSIGIAHYPDDGTDLSTLLKAADTSLYAAKKRGKNQYAFYKPELTHKAE
YRFRVEQNLREAVEKQQLSLVYQPQVKISTGEIIGVEALCRWNHPQLGQVPPPEFIATAERIGMIKPLTEWVLRTACHQAVTWKNAGFPELRMAVNISPS
HFLDNNFVSLVKHVIDETGMVPGELELEVTENVVQTNQEN-LAIFQDLKDLGVLLAIDDFGTGYSSFASLKHLTVDYLKIDKYFIHDMFVNHKSQLLIGS
MIEMGHNLEHAIIAEGVETIEQYHMLRKLGCEIAQGYLFSKPVSADEMSKFLNSN-----
>tr|K9Q6T2|K9Q6T2_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptolyngbya sp. PCC 7376 GN=Lepto7376_4374 PE=4 SV=1
--------------------------------------------------------------------SRKSEESLGHREERFSLAMRGANDGLWDWNLE
TNETYYSPRWKSMLGYEEEELENQFSTWE-KLVHPDDKNIV-LDRVQDYLAGDAFEVEMRMIHKDGHNVFVLSRAFLVRESDDKATRLVGTHVDITDRKK
AEAFDNRNAEILEMIATGKPASAIYAEIALLYEERHPGLRCSMLELENGRLLHGGAPSLPQAYCALPHGMRCCWSEPIKSSSGKVLGAFGMYYDYPALPN
EEESNDLTSAARLAGIVMERDHAQKRIRELAYTDELTKLASRAHFYEDLEELIEISDRHKRRFGLLYIDLDNFKGVNDSLGHDAGDVLLQKIAKRLEKIS
RTGDFVARLSGDEFCILVKDIDDYATAHVAQRCLERISKPVELSGRKFTPACSIGIAHYPDDGQDLSTLLKAADTSLYAAKERGKNQYAFYEQKFTDQAE
YRFRVEQNLREAVETQQLSLVYQPKIEMSTGKIIGVEALSRWYHPKLGQVPPNEFIDTAERIGMIKPLTEWVLKIACNQAVAWKRQGLPSLRMAVNISPS
HFLDNDFMPLISRVIAETGINPENLELEVTESVVQTDPQN-LEIFQQLKELGISLAIDDFGIGYSSFASLKHLAVDYLKIDKYFVNDMLTDQKSKLLVGS
MVEMGHILGHEIVAEGIETVEQYQILKSFGCEVAQGYLFSRAVNAETITNLLNKN-----
>tr|Q47V74|Q47V74_COLP3 Sensory box/GGDEF/EAL domain protein OS=Colwellia psychrerythraea (strain 34H / ATCC BAA-681) GN=CPS_4654 PE=4 SV=1
--------------------------------------------------------------------KDVRTAELLNSEERFALAMRGASDGLWDWDLA
TDDVYYSPRWKSMLGYSEHELENTLSTWA-AMVHVDDKDFV-LKNVHKFLSGDTFEVEMRMRHKVGHDVFIRSRAFKVRGENNETIRLIGTHVDITQQKK
SEFFNERNTKILELIAKGKPASKIYAEIALMYEERHSGLRCSMLELKGGKLLHAGAPSLPKSYCALPYGMRSCWSEPIKSSSGKVLGAFGMYHDYPALPN
EQESNDLTSAARLAGIVMEREQNQKRIQNLAYTDELTKLSSRPHFYINIEELVKISAREKNKFGLLYIDLDNFKTVNDSLGHDVGDLLLKKVAQRLKSAC
REIDYIARLSGDEFCIAVNNVMDYGAAHVAQRCLELISKPVELAGRKFTPACSIGIAHYPDDGIDLQTILKAADTALYAAKDLGKNRFAFYKKELTDKAE
YRFKIEQHLREAIEQQQLSLVYQPKVDIKSGNIIGVEALSRWNHPLLGQVSPVDFISMAEQIGMIKPLTEWVLKTACNQATLWKEAGFSSIIIAVNISPS
HFLDSDLVPLIKRVIKETGMLPGDLELEVTEGVIQTNPEN-LAVFEHLKELGILLAIDDFGVGYSSFASLKHLNVDYLKIDKYFIDDILVDHKAKLLVGS
MIEMGHNLEHKITAEGIESEEQATMLQELGCDYAQGYFFSKPVSANQISKLLGRK-----
>tr|A0A099KW28|A0A099KW28_COLPS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Colwellia psychrerythraea GN=ND2E_1589 PE=4 SV=1
--------------------------------------------------------------------KDVSTAELLNSEERFALAMRGASDGLWDWDLA
TDEVYYSPRWKSMLGYSEDELENTLNTWA-AMVHIDDKDMV-LGDVQSFLSGDTFEVEMRMRHKAGHDVFIRSRAFKVRGDSDETVRLVGTHVDITQQKK
AEFFNDRNTKILELIAQGEPASRIYDEIALMYEERHSGLRCSMLELDKGKLLHAGAPSLPESYCALPHGMRSCWSEPIKHSSGKVLGAFGMYHDYPALPN
EQESYDLRAAARLAGIVMEREQNQKRIQDLAYTDELTSLSSRPHFYINIEELVKISARNKNKFGLLYIDLDNFKTVNDSLGHDVGDLLLKHVAQRLKKTC
REIDYIARLSGDEFCIAVNNVMNYSAAHVAQRCLELISKPVELAGRKFTPACSIGIAHYPDDGVDLQSIIKAADTALYAAKDLGKNRYAFYKKELTDKAE
YRFKIEQYLREAIENQQLSLVYQPKVDIQTGSIIGVEALSRWHHPVLGQVSPVDFIAMAEQIGMIKPLTEWVLKTACNQANLWKEAGFSSLIMAVNISPS
HFLDSDLVPLITRVIKETGILPGELELEVTEGVIQTNPEN-LAVFEHLKQLGVLLSIDDFGVGYSSFASLKHLNVDYLKIDKYFIDDILLDHKAKLLVSS
MIEMGHNLEHKITAEGIESKEQYIMLKGLGCDYAQGYFFSKPVSANDVSILLENQ-----
>tr|A3Y9V9|A3Y9V9_9GAMM Sensory box/GGDEF/EAL domain protein OS=Marinomonas sp. MED121 GN=MED121_02545 PE=4 SV=1
--------------------------------------------------------------------KEEQSIELLKSEERFTLAMRGASDGLWDWDLS
TDKVYYSPRWKSMLGYEEHELDRSLNTWA-SMVHTKDKDFV-LTRVQDYLSNDAFEVEMRMRHKNGSYLYIRSRAFKVDETENTPIRLIGTHVDITKRKK
TELFSARNTKILAMIAKGHPASKIYDEIAYMYEERHPGMRCCMLILEGDTLLYGGAPSLPKAYCALPHGMRSCWSEPVKNAAGKVLGAFGMYYDYPGLPN
EEELNDLVSAVRLVSIIMDREQNLKRIKELAYTDELTGLSSRAQLYLSLEKRIKSAKESNEHFTLIYLDLDNFKNINDSLGHDAGDTLLQMIATRLINIT
SHTHTIARLGGDEFCIILDTQEQAGIIKFAHACLEGISQPVFLSSRRFIPTCSLGIAKYPTDGEDLPSLLKAADTALYAAKDRGKNVYAFYQVEYTQQAE
YSFKVEQALREAIETETLSLEYQAQTSVETGKILGVEALARWFHPQLGHVPPTEFIPIAERIGMIRPLTQWVLKTACQQAVDWRRSGVQDLRMAVNISPS
HFLESDFDQVIIETIKSTGIDVSKLTLEVTESAVQTNKAN-LSMFKKLKALGVMIAIDDFGTGYSSFASLKHLSIDVLKIDKYFVDDMVNDEKSTRLIKA
MIEMGQKLGYEIVLEGVENDAQFAMLKQFGVNIIQGFLFSKPASAKEIDALLPRK-----
>tr|M2Y927|M2Y927_9PROT Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Magnetospirillum sp. SO-1
--------------------------------------------------------------------LRLAEEGLRLSE--FQLAMRGANDGLWDWNLK
SNQVYFSPRWKGMLGYGEGELEASPFTWV-NLLHPDDR--L-PG---EFLKGDRIELQFRMRHKGGGDRYIRAPAFLTRDAQGRPERLVGTHIDITEAKE
AETSL-RQAAAVFTSTLEAVFVIGLGGGILAVNPAFSTISEYPEGEVLSRGMDFLLANQDDRAFQAIWQAVRENGAWQGEVSFRRRGGDAFPAWLGITSV
GDEKGEPINYVGVFTDLSRLKHSEAKLQHLAHHDPLTGLPNRVLLQLRLEHALDRSRRDGRRCAVLFLDLDHFKVVNDSLGHDAGDEVLQVIGHRLRDQM
GEADTLARLGGDEFVMVVETVAQEDAASIAQAMIDVVGTPYRLNDHEVSLRASVGVSLFPDDGEGADQLIQNADTAVHQAKQEGRNGYRFYTRSLTEKAN
RRLEMEAGLRRALDLREFVLHYQPLISLTGGRVEGVEALVRWQPPGREIISPYHFIPLAEETGLIVALGDWVLQEACTQMKSWLDLGLRLDKVAVNLSAQ
QFRLSYLQERIRDILSESGLPPCRLELELTETTIMARGDEAGIQMAALKDQGVHLSIDDFGTGYSSLAYLRRFPLDKLKIDQSFVRDIPHDEGAAEITST
IIAMAKNLKLSVLAEGVETPEQLDFLTGRGCDSCQGFFFSRPLAADDFRHWMDRA-----
>tr|M7CQ65|M7CQ65_9ALTE GAF and PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Marinobacter santoriniensis NKSG1 GN=MSNKSG1_07993 P
--------------------------------------------------------------------RRDTLEALRAKEER--SMLG-----MAATRPD
RSWLEANQALCDMLGYSVEELC--TRTWE-ELTHPEDLAPN-NT---QLVNGNEFVIEKRFIRKSGEPIDAHLAVRAVRNEDGSLAYAVSLIEDITPRKQ
AERREAMRRRILERVARGGSLEDIMLQVAYEAEAIYPGSRCSILLADDRGEQLLSGAAPNLPDFRTIWRDILQHGGWQGEIWNRRKSGESFPAWLTINVV
RNEKDEIQRYVALSSDISNKIRSDELIWRQANYDFLTDLPNRHMFQDRLEQELRKARRHKSMLALLFVDLDRFKDVNDTLGHTSGDQLLINAAERISGCL
RDSDTVARMGGDEFTVILPDLGSADAERVGAHIITALAEPYVINGQTLYLSASIGITFYPEDSTEAGQLLRNADQAMYAAKHAGRNCIRYFTKSLHDSAQ
NRLMLINDMRSAVGKQQFELHFQPIVDLVTGRVVKAEALIRWHHPERGLISPADFIPLAEETGLIVDIGDWVFREAATWTKRWNDR-FDTLQISVNTSPI
QFQNDANVPAWRAYLQTAGLNEKYLSIEITEGLLMNASEAVTDKLLGFRDAGVQVAIDDFGVGYSALSYLKRFDIDYLKIDQSFIRNLGTAENDLVLSEA
IVVMAHKLGLKVIAEGVETETHRRLLLDIGCDYGQGYLFSRPLPPDAFEAFLREQ-----
>tr|C6XCZ6|C6XCZ6_METGS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylovorus glucosetrophus (strain SIP3-4) GN=Msip34_1174 PE=4
--------------------------------------------------------------------TAALLYHLIHRQ-RYNSLTVHANDSILLFDHQ
GKLVDANDRALRMYGYTRDQMQ--HIHAR-QLL-PDAASDW-R-----LAEANGIIFESEHKHADGSTFSV--EVSACLLKIGGSDYIQAIVRDITERLR
VVEKLRESEQLLAHMSAIAHIGGWEFDVETGIGSWTREVAHIHGVEFKDNISAEFGLGFYEAESEEMWHLLDSNGKWQGEVWNRRKNGESYAEWLTIDTI
YNEHGEVIRRVALFSDITKNKQNQEVIWRQANFDQLTGLPNRRMLHDRLNQEILKADRNHQMLAVLFLDLDRFKEVNDTYGHLMGDQLLQESAHRLLHSV
RECDTVARLGGDEFVVILSGLQDDVVQDIAQSILKKFDTPFQLDNDLTHVSVSIGITIYPEDGNAGEVLFKNADQAMYVAKNNGRNRYSYFTASMQAHAQ
NRMRLSNDLHLALPGQQFELYYQPIVELATGQVHKAEALLRWQHPTRGMIPPDNFIPLAEETGLIVDIGNWVFYEAARQVKRLQSL-HHAFQISINKSPV
QFHNETGHEAWISFLLMNDLPRQSIVVEITEGLLMHTDESISAQLLGFRDAGVQVALDDFGTGYSSLSYLKKFDIDYLKIDRIFVRNLSRNSSDMALCEA
IVMMAHKLDIKVIAEGIETEEQRELLQQIGCDFGQGYLFSPPLPAPAFEAYLRP------
>tr|A0A038GKU1|A0A038GKU1_9BURK Diguanylate cyclase OS=Burkholderia sp. MP-1 GN=BG58_41540 PE=4 SV=1
--------------------------------------------------------------------ADLAKNELYQSK--LEFVLDHVPQG-IAWK--
HRYVGGNQIFAADAGLPNKHKLVGLTDFD-LRWGDDP-SAA-QEEDRRVMAGSCAHVERRAFGADGQEVWISETKVPLEDQSGEIIGVLRAYEHITQRRK
V-----EVALRLQGRAIEASINGIIISEVRGDRHIVIFANQAFEQMTGYSENDVLDADCEQLFAEVVRNALATKSEANTTLRSKRKDGQLYWNHVFVAPV
RDENNCVTHHVGVMTDVTALVDYRERLEHQAKYDSLTGLPVRTSLDESLESAILRAKTTGKQVWLFFLDLDRFKEVNDSLGHRVGDALLKLVANRLRGLV
RPSDLVARYGGDEFIMVIERSGAHEVVSLLELIVAAMEEPFNL-ERELYVEASIGISSYPKDGLDSDTLLRNADAAMYSAKASGRNGYQFYRPEFNIAAA
ERLRMSTNLRRAVKAQGLRVVYQPQVDMLTGLVIGAEALVRWDDEELGSVSPAVFIPVAEETGLIESIGEWVLRTACYQAKSWLDEGLRAIRISVNVSPR
QLERSNIVDVVRNALHDACLPASSLELEVTEGALMRNVEDVAKTLCELRSLGVRIAIDDFGTGYSSLSYLKKFSVDRIKIDRAFVREVGMDEGSEALALA
VIGIANALKFEVLAEGVEQDVHRSFLVSHGCTAAQGFLYSAPTSPMKVAEMLGGR-----
>tr|B9MI08|B9MI08_ACIET Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax ebreus (strain TPSY) GN=Dtpsy_1478 PE=4 SV=1
-----------------------------------------------------------------------------LRE---QTLLDSAGVG-IVFIRN
RALVRCNQRCAEIFGLPSPEDAIGRS--S-EALHPSR-GAF-RP---TLARGYRTER--QLKRCDGQLFWAHLTGRL-INPRDSREGSIWIIDDIDEQKR
AQAQLQAALWEKQVLFDSAMVGIVFLQERRMTRCNRHFEQILGYGPGELAGSSSRRWYLSDEDWSNVAQGSIWIVMDVSERLRIQRQLAGMHGELEQQVR
DRTRELQETVGNLHREIQDRQRDQERIYWMAHYDALTELPNRVLLAERGQDAIRHAQESGAPLAVMFLDLDNFKHVNDSLGHRIGDALLVEIAQRLRTTV
RQRDTVARLGGDEFVLLLPGANAQGAARVAAKMQEAALQPVHI-QHELSLALSMGIALFPEHGSDFETLIQSADTAMYRAKADGRNSFRFFTPTMQAQSA
RALQLTNALRRALERNQLSLHYQPQVSIATGRVCGVEALLRWHHPELGAVSPAEFIPVAEDTGQILPIGEWVLRTALAQLRTWHSQGLPALTMAVNLSAV
QFRQPQLLELVDRLLAEYGVQPHLLELELTENVAVADPHAAIATMDQLHAKGVRLSMDDFGTGYSSLSHLKRFQIYRLKIDQSFVRDLDHDGNDRAIVSA
IIRMAQALGMRTTAEGVETAHQLTFLREQGCDEAQGFYFSRPLGAPHLQQYLLQR-----
>tr|A0A0A1VN99|A0A0A1VN99_9BURK Diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. MR-S7 GN=AVS7_04607 PE=4 SV=1
-----------------------------------------------------------------------------LRE---QTLLDSAGVG-IVFIRH
RVVVRCNQRYAEIFGLSCTAEAVGRS--S-EGMHPNR-DAF-RA---VLSQGFRTER--QMRRSNGQLFWAHLTGRL-INPLDTSEGSIWIVDDVDEQKR
SQALLHAALREKQVLFDHAMVGIVFLRERRLTRCNRHFEQMLGYAPGELLGLSTRRWYLSDADWQNVAQGSIWIAMDISERLRIQAALAQMHGDLEQQVR
DRTRELSETVRDLHREIHDRQQDQERIYWLAHYDALTQLPNRVLLAERSQEAIRRAQESCSPLAVMFLDLDNFKHVNDSLGHRVGDALLVEIAKRLRGIV
RERDTVSRLGGDEFVLLLPGANAQGAARVAAKVQEAARQPFQI-AHELCVAPSMGISLFPEHGSDFETLIQAADTAMYRAKADGRNAFRFFTPEMQAQST
RALLLDNALRRALERGQFTLHYQPQVSIATGSVCSVEALLRWNHPDLGQVSPGEFIPVAEDSGQILQIGEWVLRTALAQLTAWHAAGMPWLTMAVNLSAV
QFRQPQFLDLVDRLLQEFSVPPHLLELELTEGVAVDDPHSAMSTMEQLHAKGVRLAMDDFGTGYSSLSQLKRFQLYKLKIDQSFVRDLDHDGNDRAIVSA
IIRMAQALGMRTTAEGVETADQLAYLRSQGCDEAQGYYFSPPLPAANVESYLLQR-----
>tr|J1ES83|J1ES83_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_00056 PE=4 SV=1
-----------------------------------------------------------------------------LRE---QMLLESAGVG-IVFIRQ
RVVVRCNPRYAEIFGYESAQRLAGLS--S-EAFYPDR-DAF-RP---VLARGYRVER--QMRRRNGRLFWGSLTGRL-INPQDTSEGSIWILDDIDEHKQ
AQALLSAAVREKQVLFDQAMVGIVFLRDRHLTRCNRHFEHMLGYGPGELAGSPSRRWYASDEDWDDPDQGSIWITMDISERKQAQAALARVHEQLEQQVQ
DRTRELRETVDNLHREISDRKADQDRIYWLAHYDPLTGLPNRTLLSERAQEAIRVAQEGNTPLALIFLDLDHFKHVNDSLGHRVGDALLVEIAKRLRAVV
RDKDTVSRLGGDEFILLLPGANAHGAARVAGKLQEASRQHYQI-DHELTMAPSMGVALFPQDGADFDTLTQSADVAMYRAKLDGRNTFRFFTPEMQAQSV
RALQVENALRRALERGQLYLHYQPQIHLATGQVHSVEALLRWDHPQMGSISPTEFIPIAEDSGQILQIGEWVLRTALTQLKDWHANGFPGLTMAVNLSAI
QFRQPQLPELVSRILTIFELPPDCLELELTEGVAVDDPHSAVATMDSLHSRGVRMSMDDFGTGYSSLSQLKRFQIFKLKIDQSFVRDLGDDGNDRAIVSA
IIRMAQALGMRTTAEGVETPGQLAFLREQGCDEAQGYLFSRPLPADELELFLRQY-----
>tr|H0C359|H0C359_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax sp. NO-1 GN=KYG_20625 PE=4 SV=1
-----------------------------------------------------------------------------LRE---QILLDSAGVG-IVFLRQ
RSVVRCNQRYAEIFGYAAAERMVGLS--T-EAFYPNR-EAF-RP---VLAQGFRVER--QLRRRDGSAFWGSLTGRL-INPHDTTEGSIWIVDDIDEQKR
AQAALSAAVREKQLLFDSAMVGIVFLRDRHLTRCNDHFEQMLGYEPGELMGSPSRRWYASDAAWVDPAQGSIWITMDITERKQAQAALARAHENLERQVQ
DRTRELRETVDNLHQEIRDRKADQERIYWLAHYDALTGLPNRTLLSERAQKAIRVAQAGGTPLAVIFLDLDHFKHVNDSLGHRVGDALLVEIAKRLRAVV
RDKDTVSRLGGDEFILLLPGANAHGAARVAGKLQEASRQHYQI-DHELTMAPSMGIALFPQDGADFDTLTQSADVAMYHAKLDGRNTFRFFTPEMQAQSV
RALQLENALRRALERDQFHLHYQPQMCLATGSVHSVEALLRWHHPQLGPVSPAEFIPIAEDSGQILQIGEWVLRTALAQLKTWRCGGFPGLAMAVNLSAI
QFRQPQLPELVSRMLAEFDLPPDSLELELTEGVAVDDPHAAVATMDQLHARGVRMSMDDFGTGYSSLSQLKRFQIFKLKIDQSFVRDLGNDINDRAIVSA
IIRMAQALGMRTTAEGVETEGQLAFLREQGCDEAQGYHFSTPLPAPELEAFMRRI-----
>tr|C5T2T4|C5T2T4_ACIDE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax delafieldii 2AN GN=AcdelDRAFT_1214 PE=4 SV=1
-----------------------------------------------------------------------------LRE---QTLLDSAGAG-IVFMRQ
RVVVRCNQRYAEIFGYEAPEQLAGLG--S-ESFYPDR-EAF-RP---AMSQGYRVER--QMRRRNGDLFWGHLTGRL-INPQDTAEGSIWILDDIDDHKQ
AQAQLSAALREKQALFDHAMVGIVFLRDRHLTRCNRHFEQMLGYGPGELATSPSRRWYASDAQWADPSEGSIWITMDITERKQTQAALALAHERLEQQVQ
DRTRELRETVDSLHSEIRDRKADQERIYWLAHYDALTGLPNRTLLGERAEHAIRLARESGTPLAVVFLDLDHFKHVNDSLGHRVGDALLVEIARRLRAVV
REKDTVCRLGGDEFVLLLPGANAHGAARVAGKLQEASRQYYQI-DHELTMAPSMGIALFPGDGEDFDTLTQSADVAMYQAKLDGRNTFRFFTPEMQAQSV
RALQLENALRRALERDQLRMHYQPQMDLTTGRVHSVEALLRWHHPQLGTISPAEFIPIAEDSGQILPIGEWVLRTALQQLKAWRDRGFADLSMAVNLSAI
QFRQPQLPEMVSQILAEMELPSDALELELTEGVAVDDPHTAAATMNQLHARGVRLSMDDFGTGYSSLSQLKRFQIFKLKIDQSFVRDLGNDGNDRAIVSA
IIRMAQALGMRTTAEGVETESQLAFLREQGCDEAQGYHFSTPLPAPELETFMRRR-----
>tr|A1TQF4|A1TQF4_ACIAC Diguanylate cyclase/phosphodiesterase OS=Acidovorax citrulli (strain AAC00-1) GN=Aave_2620 PE=4 SV=1
-----------------------------------------------------------------------------LRE---QTLLDSAGVG-IVFIRQ
RQVVRCNPRYAEIFGYASTREAIGLS--S-QSLYPDS-AAF-RP---TLSLGYRCEC--QMRRKNGRLFWASLTGRL-INPLDTSEGSIWIVDDIDEQRH
AQIRLHAAIREKQALFDHAMVGIAFVRNNRLTRCNRHFEQMLGYAPGELSEGSARQRHFSDADWLFPEQGCICIAMDVSEQRKTQAELARMHAELEQQVQ
ERTRQLSETVESLHREINDRKHDQERIYWLAHYDPLTGLPNRTLLAERAQHAIRVAQENGTPLAVVFLDLDHFKHVNDSLGHRVGDALLVEIAKRLRAVV
RDRDTVSRLGGDEFILLLPGANAHGAARVATKLQEASRQPYQI-GHELTMAPSMGIALFPDDGCDFDTLTQSADVAMYRAKLDGRNTYRFFTPEMQAQSV
RALLLENALRRALEREQLHLHYQPQITIASGEIRSVEALLRWDHPELGPISPAEFIPIAEDSGQILQIGEWVLRTALAQLQAWHAMGLEWLSMAVNLSAL
QFRQPLLPELVSRILEETRLHPQRLELELTEGVAVDDPRSAIATMDQLHARGVRMSMDDFGTGYSSLSQLKRFQIYKLKIDQSFVRDLGVDSNDRAIVSA
IIRMAQALGMRTTAEGVETAEQLEYLRQQGCDEAQGYYFSRPQTAQAITPLLQQR-----
>tr|A0A014Q623|A0A014Q623_9BURK Diguanylate cyclase OS=Comamonas aquatica DA1877 GN=AX13_11690 PE=4 SV=1
-----------------------------------------------------------------------------LRE---QTLLDSAGVG-IAFIKH
RVVARCNHHFAKIFGFAHSQQAIGIS--S-TTLHASR-EDF-KD---SLIDGFKTER--RLRRRSGHLFWASLTGHL-INPTAPQEGSIWIIDDIDEECR
RKALLTATLREKQLLFETAAVGIVYWRRGTPSRCNPHLASMLGYEAEELIQLANVPATLRHATSLDHSQGEVWILVDITERKHIQAILTQTQAELESLVH
ERTNELSVTIQTLHQEVEDRKRVQERIHWMAHYDPLTGLPNRALLAERSKAAIATAQANSSPLAVIFLDLDRFKHVNDSLGHKVGDALLEQIAKRLRAVV
REKDTVARLGGDEFVLLLPGANAQGAARVAGKLQEASRQPYQI-GHELSMAPSMGIALFPQDGQDIDSLTQSADVAMYHAKLEGRNTYRFFTPQMHAKSV
RALQLENAMRRALERNEFTLHYQPQICLHTGEIRSVEALLRWQQAELGAISPAEFIPVAEDSGQILQIGEWVLKNAIAQLQAWHQAGFPHLKVAVNLSAI
QFHQPQLPELVGRILQESDIPATALELELTEGVAVHDPQAATQTMDALRERGVWLSMDDFGTGYSSLSQLKRFQIYKLKIDQSFVHDLDHDSNDRAIVSA
IIRMAQALGMQTTAEGVETAAQLEFLREQGCDEAQGYLFSRPLPAPQIHALLSSY-----
>tr|H0C067|H0C067_9BURK PAS/PAC sensor-containing diguanylate cyclase OS=Acidovorax sp. NO-1 GN=KYG_15290 PE=4 SV=1
-----------------------------------------------------------------------------LRE---QTLLDSAGVG-IVFVRQ
RVVVRCNPRYAELFGYDSPQELIGQS--M-EALHPSN-EAF-RA---TLSQGFRTEW--RMRRRTGEVFWSNLTGRL-INPDDTAEGSIWTIDDIEAYKR
A-----QEALDRAHENLERQVRDRT---------------------------------------------------------------------------
---RELRETVDNLHREISDRRADQERIYWLAHYDALTGLPNRALLAERARSAICLAQEGGTPLAVIFLDLDHFKQVNDSLGHRVGDALLMEVAQRLRATV
RDNDTVSRLGGDEFILLLPGANAHGAARVAGKLQEALRQPYQI-DHELTMAPSMGIALFPQDGADFDTLTQSADVAMYRAKLDGRNTFRFFTPEMQAQSM
RALQLENALRRALEREQLHLHYQPQVSLSTGSVHSVEALLRWLHPQLGGISPAEFIPIAEDNGQILQIGEWVLRTALAQLKAWRCSGFPGLTMAVNLSAI
QFRQPQLPELISRMLAEFGLPPNALELELTEGVAVDDPHTAVATMDQLHALGVRMSMDDFGTGYSSLSQLKRFQIFKLKIDQSFVRDLGNDPNDRAIVSA
IIRMAHALGMRTTAEGVETEDQLAFLRAQGCDEAQGYYFSPPLPTAGMQTYLLQQ-----
>tr|Q21TK2|Q21TK2_RHOFT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T11
-----------------------------------------------------------------------------LRE---QVILDTAGVG-IVFIKN
RLVVRCNQRFGQIFGHSDAAAILGST--S-PSLYPDD-LAA-HP---AMAQGFKSEV--LMKRRDGSSFWAHLTGKL-VNPADPLAGSIWIVDDIDEQKA
AQAQLQSVLTEQNLILDNAMVGIVFLRNRIATRCNQRFETLLGYEPGELQGVSSRQWYLTKQDWSDPEQGAIWITMDITARKTAENELLQARADLEKLVE
VRTLELSRTVQELKNKAAEQKTAEAYIQRLAHFDALTGLPNRLLLNDRCQQALSVAQRGRQSVALMFLDLDHFKNVNDSLGHRVGDEVLVELAARLKAAV
REQDTVSRLGGDEFILLLPDTDAMGAAHLAEKLLQTALQPILI-EHELTVTPSIGIALYPKDGTDLDTLSRCADAAMYRAKADGRNGYRFYTAQIQAHSD
RMLLLDNALRRALERKQLELHYQPQIALMSGQVVGAEALLRWTHPELGAISPVEFIPIAENNGLILPIGEWVMRTATRQLSTWIARGMAPITMAVNLSAL
QFRNPNLPQLVTRILEDAALPPQLLEIELTEGVAMTHPLEAVAVMNELHQRGVRMAIDDFGTGYSSLSYLKKFQVYKLKIDQSFVRDITEDPDDKAIVGA
VISMASSLGLQTIAEGVETEGQLEFLRARGCNEAQGFYFSRPLPTQAFEDFVRKQ-----
>tr|S2XNR2|S2XNR2_DELAC Uncharacterized protein OS=Delftia acidovorans CCUG 15835 GN=HMPREF9702_00882 PE=4 SV=1
-----------------------------------------------------------------------------LRE---QALLDNAGVG-IVFIRQ
RVIVRCNQCYADIFGYAGEHALVGIN--S-EHLHPSR-DEL-RR---TLSAGFRTQR--RLRRKDGSLFWGELTGRL-INPGDAREGSIWIVSDIDDRLR
A-----QQALSQAHELLEQQVRDRT---------------------------------------------------------------------------
---RELSATVENLHREIADRKLDQERIYWMAHYDALTGLPNRTLLAERSARAIELAKVNDTPLAVMFLDLDHFKHVNDSLGHRVGDALLVEIARRLRAVV
RDRDTVARIGGDEFVLLLPGANAQGAARVAGKLQEASRQAYQI-DHELTIAPSMGIALYPRDGHDIDSLTQAADAAMYHAKQAGRNTYRFFTPQMQAQSL
RALQLENALRRALERNQLYLHYQPQITLSTGRVRSVEALLRWEHPELGSVSPAEFIPVAEDSGQILQIGEWVLRSAMQQLQAWRNAGLRDLKVAVNLSAI
QFHQQQLPEIINRILLDSDLPADSLELELTEGVAIHDPRQATATMDRLREHGVRLAMDDFGTGYSSLSQLKRFQIYKLKIDQSFIQDLDHDSNDRAIVSA
IIRMAQALGMQTTAEGVETEAQLQFLREQGCDEAQGYHFSRPLPPQALEAFLRSQ-----
>tr|A0A0C1TZX7|A0A0C1TZX7_9DELT Diguanylate cyclase OS=Geobacter sp. GSS01 GN=SE37_00235 PE=4 SV=1
-----------------------------------------------------------------------------FRE---VLLRQMVDGV-ITFGED
GMIRSLNPAAERMFGYRDAEAA-GMA--I-DCLLSADGGYF-RG---QGTRQY--EL--EGIRRDGNRFVADLSVSR-IVF-EGRRAVIGIVRDITARKR
DEQNLLVFKRAIESSVNGITITDAVNGENLIIYVNPAFERMTGYAGHEVLGKNPRFLRGNDRDQRKLAMALEERREGYFVLRNYRKDGSQFMNELYVAPV
RDRDGAVTNYIGIMNDISDQRRYEEQLVYQANHDPLTGLPNRNLLQDRLGQALALESRRRNPIGVMFLDLDNFKKINDTLGHTVGDMLLKAVANRLRNCV
RGGDTVSRLGGDEYILILPNVKEHDVTTVAKKLIGLFSTPFLL-MHELYITASIGIALFPSDGDTVDALLKNADAAMYHAKEQGKNNYQFYSEEMNTRVF
ERMALETSLHRAIRQQEFLLYYQPRVDLRTGRISGVEALVRWNHPEMGLVSPARFIPLAEETGLIVPIGEWVLRTACAQNKAWQEAGLPPLRMAVNLSAR
QFRQENLIQMVADVLAETGLDPRWLELELTESLLMERAEQSVSILRSLADMGIDIAVDDFGTGYSSLGYLKRFPITNLKIDQSFIRDIASDPDDAILVRT
IITMAHGLGMKTVGEGVESLEQVDFLCRHGCEEVQGYYFSRPLTAEGCEELLREE-----
>tr|C1DCZ4|C1DCZ4_LARHH Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Laribacter hongkongensis (stra
-----------------------------------------------------------------------------RAQ---DALIEQSLVG-IYILKE
HTLIYANQRASEMLGYPAGALA-GKS--L-VDLMPPG--VA-HRRHRDNITEY--VL--PLIHRNGHRLSVELHSRL-TEFRG-ERVIVGVGLDISARLE
TERTLQLAATVFENSSEGILLTDADGTLITVNPAFTRITGYTEEQALGRRSRMFRTDHVGQAT-NMQMMQSLAEHGHWQGEMFDRHRDGRLYPVWLSLSA
VYDEDRVSNYVGVFTDISRRKAAEDRLVFLASHDPLTRLLNRDALFRKLEDI-CLS-GIEQSFAVLFIDLDRFKLINDSFGHATGDNLLRIVAARLSFVV
GSNALLARQGGDEFTLLLEDTGQTAVIDMANRLLDELSQPITL-EQELHITASIGIALAPEHGKDAATLLRHADTALYRAKDAGKNTFAFFTHTLHGLSN
QRLALENALRHALPRNQLTLAYQPQIDPHRQRLVGVEVLLRWHHPELGQVSPATFIPLAEETGLILPIGRWVLETACRQLAAWDTAGFSVGHVAVNLSAH
QFNDPGLTHHLKAVLSDSGLAARRLELEVTESTLINNPTAAIALMTELKELGVRLSIDDFGTGYSSLAQLKRFPLDTLKIDRTFVSGIPADASDLAITEA
IIAMAKKLSLSVVAEGVETADQRDFLARCGSELIQGYFYSPPLAAEALHSFSRMF-----
>tr|F0J587|F0J587_ACIMA Putative signaling protein OS=Acidiphilium multivorum (strain DSM 11245 / JCM 8867 / NBRC 100883 / AIU301) GN=ACMV_07890 PE=4 S
---------------------------------------------------------------------------MTLAGDIVNLAVEESGTGIWDRDVV
TGEIRYSRGWWRILGYAEMPARSHIEAAY-ARVHPDDLDYV-RQTMQDHFDRARYEVEHRLRCADGSYKWVLSRGMVVRDIAGRPVRMVGTTTDITTLRT
LAEELAREKAEARFRAEQLAERTREQAAAHRLAQIGSWQWDLAAGEIRFSPETWQLAGGEARNRPGTAGHRLAAGAERAAATGAPVRLELSWAPTGRWLE
ADLYPGEDDISLFVRDVTERKLTQDRLIEAAETDSLTGEFNRRGFFTRLEAALTAQ-ARGRAMALICADVNYFTEINDSFGHGVGDEVLKTVARRLKSCL
RPRDILARTGGDEFMILLNGMRRGDATTLARRIVGAMEERFELGDLSLRISLSIGLAIASLADRDAARLCRHADLALYETRTEAPGSFRVFTPAMEQESL
RKRQLKRDLADALGRSELELAFQPIVRTADGTIAAAETLLRWNHPEQGRIPPAEFIPLAEESGLIAPIGAWVLRQACAAACRWPE---TV-GLSVNVSPR
QIELADLPALVRDVLEATGLAPRRLHLEITETVLVSRNRHYLATLHRLRELGVRLVLDDFGTGYSSLAQLDAFRFDAMKIDQSFLRRIRAETDETPILNA
IVGMATAIRMPITVEGVETQVQLNHVRRLGAACVQGFYFGQPVNEAGMRGLLARG-----
>tr|A0A066PLF4|A0A066PLF4_9PROT Diguanylate cyclase/phosphodiesterase OS=Acidiphilium sp. JA12-A1 GN=ACIDI_95c00060 PE=4 SV=1
-----------------------------------------------------------------------------MSRTLGALVLGGRGVVLWDLDPV
AGLIRHYHGQAR--EGVDCPPAETVEQVC-ARVHPDDRARV-GAALRCDDGQPEFEIGYRARDAAGGWIRQVARGRVVRDAAGRPLRVVGITIDLDLVPD
LPATPCGGGDSERLAALALELAQRTEELASAHRLARVGAWRWDLARRRIWLSVETTWLLGLEGGAEAHCRELRMAVSRAMRDGAGGHFELFWPPTDLWLE
ASLFADGGDISLFLRDISEKRLAQQQLRYAASFDFMTGAANRGTLFSRLSAQLERQ-DAGDLTALLCLDLDYFKEINDQHGHPAGDAVLRQFVSRLRLCL
RSQDLLARCGGDEFVVMQTGVGGADAIALAERILAIMRAPFDVDGISLPSSVSVGIAVSSLGMTDADALYNQADRALYVAKSKARGSYRLFHPDMQRADE
AGRRLRAELSGALTRGEFALAFQPIVQLASQRIVGVEALLRWHHPERGLILPAEFIPVAEESGQIASLGAWVLGTACKAARHWPE---DV-KISVNVSPR
QFELGDIRLVVGDALAAAGLPASRLKLEVTESVLLSQNASSIHVLQDLREQGVILVLDDFGTGYSSLSYLDTFKVDIVKVDKSFISRIRAPGDRQPIFEA
IMGMTAALNLPVTAEGVETRVQLDYVTRLGCEWAQGYYFARPVSEYELRRRLQGF-----
>tr|Q0ACK6|Q0ACK6_ALKEH Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 1
-----------------------------------------------------------------------------------HRVLEASPAVTYALTQS
LRPVYISAHIEELLGYPVADWMADPQFWR-QCLHPDDRERV-LH----LPEG---DHEYRVRHRDGSYRWVHDRLRLMPARDGRPAMAVGVWQDITHRAR
ADRLLRTLSHLTARVTGDDFFRTLVRHLAEALDMRYVLLGELPGHPPTRVHTRALYADGAIRPNREMWEALKSRGHWQGELWNRRADGETYPSLLSVSAV
TNDNDEVTHYIGIASDITSHKAAEQHIDYLAHYDTLTGLGNRRLLEEELERMLRNA-RGGRPFALFFLDLDRFKNINDTLGHESGDRLLEEVADRLRDLA
GPQATLCRIGGDEFAILAPGLSHRQTAGIARQLVEGISRPYEI-TRPLVVTCSVGVAVHPRDGTRREALISAADTALHYVKAHGSNHYQFHEPGMTAAAA
ERLHLENDLREALLRGEFELYYQPVLDTERLTVCGAEALLRWHHPEAGLIPPDRFIPLAEETGLIRPIGTWVLREACAQAARWRRLGLTGMTVSVNVSGE
QFWRDELPQAVRQALEAQALAPDALVLEITESVLMHGSANTETRLRELKAMGVGLSLDDFGTGYSSLSYLKRFPIDTLKIDKSFVRDMVRDEHDRTLAQT
VIAMGHGLGLQVVAEGVESAEHLPLLRRARCDRVQGYHFSRPLPARALSRWIQQH-----
>tr|C6HZ81|C6HZ81_9BACT Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Leptospirillum ferrodiazotrophum GN=UBAL3_94530058 PE=4
-------------------------------------------------------------------------HRWEEEHYRFEAIFASSVDAILAVDPM
RHIVLASPSVSRIFGYDPDELVGRS--I--SILYARTEDFQGRLRYSREAEDSLSAYEVEYRRKDGSTFPGEASGRKILSGSGAIAGYMVTIRDISRRRQ
LMNALAREKVTLKSLGEGVIVTDASGLVTFMNPAAEILTGWSFLEASGQPVGTVYL--AVSEETQRCLSAGHIVGLSNHTCLLTRHGRKLAVE-DSASPI
RDGER-TTGVVLVFRDVTEKREMERQLAHQARYDYLTQIPNRVLFHDRFDQALARARRSGSPLALLYMDLDSFKEINDTLGHAAGDIVLRQAAERLVKAV
REEDTVARMGGDEFTVIMTGFSGEEVVTSVGRLFLALSEPMMVGGQEVSVTASVGVAVFPEDGEEADSLLRHADIAMYKAKERRGNAVVFFRADLTGELE
KRVSFSADFRRALERSELLLEFQPEVEIVSGRIRGVEALLRWNHPLQGRLLPESFLPQLLRGGLMAELSLWVLKKAARQALAWPHSGEPPLPVSVNLSVR
ELRGSSPVVRLREVLAETGLPPERLEIEIAFPEGRLG--DDVPVLGGMRDLGVKLVADDFGEGIVSLDILRSGLFDRVKLSRQLSPGGDSGGFDAAMLRG
VLSMLRDLEIPAVAKGAESRESLRILREAGLRFIQGYALSRPLSPHEIAGLAASG-----
>tr|Q2VZL7|Q2VZL7_MAGSA Hypothetical 918 kDa protein Y4LL OS=Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) GN=amb4154 PE=4 SV=1
-------------------------------------------------------------------------ENYRLSELHNRAIVDNTADAIVTFGED
GGIGTYNPSAERIFGYAPPEIVGKQ--I--SLLIPELIK---------PDPFLDHRTEVVGVRKTRAHFPLELSLASMEL--GGQRLYVAIGHDITLRKA
NEAELVNQKTTINALPDLICFKDGKGRWLVANQFYLDLVGLSGVDYVGRTGPELAR--LSHNFQERAWKDGKPLSYEKAMETPSRGTK--VFD-MLKIPL
FKPDGRRSGLVLVGRDVTERKLAAARIQHLAHHDALTELPNRVLFQERLRQSLAQAKRSGWKLALMFLDLDKFKDINDTLGHHVGDLLLRAVAKRLTRCV
RETDTVARLGGDEFAVILTNLDDEGASRVAESIIAGIADPFGLDEHEVRTSTSIGITLYPDDSIDADQLLKNADLAMFRSKAEGRNNYHFYVAQMDAEVR
ARKLIENDLRQALGTEQLELHYQPLVEMSSRRIVGCEALLRWNHPTRGWVPPGEFIPIIERSDLIGPLGRWILHRACQQGREWQRDGLEPMKIAVNLSPA
QFKQTSIIAMVADILDQTGFAPDQLQLEITEGIAMQNVDATIEVLQSLRAMGVVISIDDFGTGYSSLNYLKRFPVDKLKIDRSFVVDIGLHPDNAAVVEA
IVNLGHSLRTRVNVEGIETKEQLDFLQAHKVDEAQGFYFSKAVPADQFAHLVRTK-----
>tr|U4QQ30|U4QQ30_9BACT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptospirillum sp. Group II 'C75' GN=C75L2_00400006 PE=4 SV=1
----------------------------------------------------------------------------LQPEFEHQFILQSMGEAILAVDLS
RQILWINVGFTRLFGYDPEEVVGRK--P--DFIYADRNDYQGRLRYNLEAPSVQTPYEMRYVKKDGQVFWGEAWGAAVHN--GDRIGFMVAVRDISRRKQ
LIHDLHLEKVTLKSIGDAVVTTDEHGRVTYVNPVAEHLTGWKVEEADGHPVSKVFR--IVNEYSRRALLEGTIVGLANHTLLLSRSGEEFSIE-DSAAPI
QDNNGEIRGCIIVFRDVTEKRKLEQRIAYQANFDSLTDLPNRHLFQDRLSRAVGQAHRTGSLVALLYLDVDYFKNINDRMGHPYGDRVLVELGKRLKTVV
RETDTIARIGGDEFAVILCDLHDSEAMVLGRRLMIEAAMPFRIDGSRADLTVSIGVALYPEDGTDATTLIRNADIALYQVKREGRNNIAFFSREMNRFVQ
STLKTESELREALDKNRFYLAYQPIVHLGSALAVGVEALLRWRHRGK-VRFPEEFVPIAEEMGLILPLGQWILREAIREAGVWIRQGINLGRLTVNVSVK
QIHSEGFSDFLESTLRENGLPPSVLEIEITERTLMFRDHHTVSTLNRIREMGVKVSIDDFGIGYSSLNYIRNFPVNTLKIDRSFLAEMLDNHYDRAIVRA
ILAMAQSLSIDVVAEGVERLEQARFLQENGCLMAQGFFYSEPVSPEEIFRYFRRT-----
>tr|I0IM17|I0IM17_LEPFC Putative PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Leptospirillum ferrooxidans (strain C2-3) GN=LFE_06
------------------------------------------------------------------------------------------------MDLD
RRILWVNPAFVRLFGYSSGEMVSKP--I--ALLYANPVDYQGKLRYSRNSPSDSHPYEMQYRKKDGSTFWGEAHGAVVIN--EERIGFTVSIRDITRQKQ
LIHDLHLEKVTLKSIGDAVITTDEHCRITYLNPLAEEMTGWGSDEAMGHPIAQVFQ--IVNEYTGRALKEGVVVELANHTLLIRRDGKKFSIE-DSAAPI
RDDEEKVRGCVIIFRDVTEKRRLEQKISYQANYDALTGLPNRHLFQDRVTQAIAQAHRTGRLFALLYVDVDHFKNINDRLGHPFGDRVLVELGRRFTSIV
RESDTIARIGGDEFAIILGDLSDTEALVLGHRLLNESVTPFRIDDSRADLTVSIGVTLFPDDGTDMTSLVRNADIALYQVKKTGRNNIQFFSQEMNRIVQ
KRLKIATELQDALDQNQFFLHYQPIVDYAQSRAIGVEALVRWKHRNK-TRHPDEFIPVAEEMGLIVPLGRWVLQSALQQMRIWIDQGFLLNRLAVNVAVK
QIHSAGFVDFLEYLLKENRIDPALLELEITERTLMFQDHHTLETLSRIRDLGVSISVDDFGTGYSSLNYIRNFPVNTLKIDRSFLTGLFNNHYDQAIVLA
ILAMAKSLSLDVVAEGVEQEEQDRFLRNNGCYLAQGYYYGHPVSPEKVQPLFDRI-----
>tr|U4QUE2|U4QUE2_9BACT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptospirillum sp. Group II 'C75' GN=C75L2_00800001 PE=4 SV=1
----------------------------------------------------------------------------FESAFEHQFILQAIGDAIFAVNLD
RRILWVNPAFANLFQYSPEETIGKK--T--AFLYASSDDYQGRVRYNRDSLPDNHPYEVQYRRKDGSTFWGEARGAIVSN--GERIGFTVSIRDITRRRQ
LIRDLHHEKVTLKSIGDAVMTTDAQGQVTYLNPLAEELTGWRSDEAKGNLVSRVFR--IVNEYSRRVLEQGVVVGLANHTLLLCRDGREFSIE-DSAAPV
KDSEGILQGCVIVFRDVTEKRKLEQRIQYQANYDALTGLPNRHLFQDRLSQAIVRVQRSGRLFALLYLDVDHFKNINDRLGHPFGDHVLVELGRRFQNVL
RETDTIARIGGDEFAIILEELSDNEALVLGRRLMNEASSPIRINHAKSGLTVSIGIALYPGDGTDATSLVRNADIALYQVKKSGRNNIQFFSREMNRTVQ
KHLKIASELREGLDRKQFFLHYQPIVDLEQGRAIGVEALVRWKNRKT-IRYPDEFVHVAEEMGFIVPMGNWVLKEAFQQLRTWMDQAIPLNRLTVNVDVK
QIHSNGFVDLLEFLLKENCVDPPSIEIEITERTLLFQDRCVMSNLSRIRDLGVRISIDDFGMGYSSMNYIRNIPVNTLKIDRSFLSDLFDNLYDQAIVRT
ILTMANSLSLGVVAEGVEYGEQERFLRENGCTLVQGFYYGQPVSPENIQPLFEQI-----
>tr|U4QW58|U4QW58_9BACT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptospirillum sp. Group II 'C75' GN=C75L2_00630003 PE=4 SV=1
----------------------------------------------------------------------------FESVFEHQFILQAMEDAVIATDLE
RHVLWANPAFSKLFQFSSEETIGKT--T--AFLYADPSDYQGRIRYHASAPSDPRPYEVLYRRKDGQTFWGEARGATITN--GDRIGFTVAIRDITRRRQ
LMRDLRHEKVTLKSIGDAVITTDENSRVTYVNPIAEELTGWQSGEAHGLPIGQVFH--IVNEYTRRALRDGTIVGLANHTLLLGRDGREWSIE-DSAAPI
KDDEETIRGCVIVFRDVSEKRRLERQIAYQATHDALTGLPNRHLFQDRLVRTIARAHRSGHSFALLYIDIDHFKNVNDRLGHPFGDRVLVELGQRLKGVV
RETDTVARLGGDEFAVILEEVSDNEGMVLGRRLMHEASLPFRIDEARVDLTVSIGVAQYPEDGTDATLLVKNADIALFHVKGDGRNSIQFFSEEMNRTVQ
KRIVIENELREALDRDEFFLLYQPIVDLERGKAVGVEALLRWRHGDE-ARLPEEFVPVAEEAGLIVPVGRWVLETALRQTRRWLDQGFAPGRVTVNLAAK
QLHSLEFAAFLESLLAETRVEASLLELEVTEGTLLHRDHQTRETLSKIREMGVRISIDDFGTGYSSLNYLRHFPVDTLKIDRSFLTGFPSNHYDRAIVRA
ILALAKSLSLDVVAEGIEREEQARFLRDDGCVLVQGYLYSHPVSPDEIPPFFGRT-----
>tr|G2FPY9|G2FPY9_9FIRM Sensory box protein (Fragment) OS=Desulfosporosinus sp. OT GN=DOT_1763 PE=4 SV=1
-----------------------------------------------------------------------------------------VLDLIIFISPD
GQIIDANEAAVKRYGYTREELTQMY--V--HNLRLPEDRL--TVPDFLQKAQKGLQLELQHVCKDGSVFPIEISAKGATS--G-KPIIISLIRDITKRKN
AEAAIWLEKVTLESIGDAVITTDVYGNVEYLNPIAETLTGWKNTEATGLSLEEVFR--IVNEETRRCLKEGRIVGLANHTVLISRMGHTIAIE-DSAAPI
RDRNRVVIGAVLVFHDVSDKRNLMKEMAYQAHHDALTGLPNRLLFNEHLNLALSHARRKQGKLAVLFLDLDRFKLINDTMGHSLGDLLLNVVAERIREIL
REGDTLARQGGDEFLILLAEISNHEVVKVSERILGVFAHPLMLDGNEVYMSTSIGISLYPSDGSDLETLVKQADTAMYYAKEQGRNNYQFFMTGLNIKAN
DRLSIENSLRKALERGEFVLHYQPQVDLESGFIVGMEALIRWNANDRGMVSPAVFIPIAEETGLIVQIGEWVLRTACAQNVVWQEQGYPFLRMAVNISAR
QFREPNFIKTVEGILQEIGMDPQWLELEITESIAMENGEASVAMLSSFKELGIRISIDDFGTGFSSLNYLRRMPIDTLKIDQSFIQDISIGENGEEVVTA
IIQLAKNLRLKVIAEGVETNTQCSFLKNKQCNEMQGFLFSKAVTSEEMEKLFDQP-----
>tr|T2IBA0|T2IBA0_CROWT Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Crocosphaera watsonii WH 8502 GN=CWATWH85
-------------------------------------------------------------------------MALRESEALFRNMADHAPVMVWVTDET
GYSTYVSQSWYDFSGQKEGTALGFG--WL-DVIHPDERELKRFLE--FNEKRQPFSIDYRFRRRDGVYCWGIDAGKPRFS--GQFKGYIGSVMDISDRKR
MEEQL----ECVATTQDMMALIDQNYTYQIVNDAYARNFQRAKEEIIGKSFVEI-----VG--EERCLQ-GEEVRYETWFDL---GEEQRYYH-ALYSPY
REANKGVTSAVVNIHDITQIKESEQKLYYQAHHDTLTNLPNRMLMNTRLEQSIQQATRKGDKLAVVFIDLDRFKNINDSLGHRAGDSLLEQLAQRLCQQR
RKSDTVARISGDEFVVILEDIKDQHAGMVVGKLMRTFEEPFIIEGRTIKMTSSMGLSLFPDDGTDVATLLRNADAAMYRAKEDGRNTYCFYRKEMTSTVF
EYMLLENALREALKKKEFYLLYQPQIEMLSHRCLGIEALLRWHHPELGVVSPAQFIPIAEQSGLIQEIGTWVLTTACRQAKIWLEQKLDFGRIAVNVAAP
QIQHGDFIQVVENVLKTTGLPAAYLELELTEGLLMKQTEQNIKQLEKLQGMGIKLTIDDFGIGYSSLNYLKRLPIDKLKIDQSFIRDLPHDTNDTAISQA
VIALGYALNLQIIAEGVENEEQAAFLKEKGCHQAQGYFFSQPIPPQQVSALFA-------
>tr|A4U4R0|A4U4R0_9PROT Sensory box/GGDEF family protein OS=Magnetospirillum gryphiswaldense GN=MGR_3935 PE=4 SV=1
-------------------------------------------------------------------------ENYRLSELHNRAIVDNTADAIVTFGED
GAIGTYNPAAIRIFGYDPYEIVGKS--V--GLLIPGVLGK-GQ---LETERFLDIRAEVVGRRKIGASFPLELSLNAMEL--GGQRLFVAIAHDITERKA
AEEELRKQKSTINAMPDLVCFKDGKGKWLVANKFYLDIAGLDHVDYHGRTSADLAH--MSRGFGERAWQEKKPVAYEKELPTPDGGAK--VFD-VIKIPL
YEEDGARRGLVMVGRDVTERKLAAARIHHLAHHDSLTGLPNRVLFQERLRTALAQAKRLGHKVALMFLDLDKFKDINDTLGHHLGDLLLKAVAKRLLRCV
RETDTVARLGGDEFAVVLTNLDDEGASNVAESIIASISEPFGLDEHEVNTSTSIGITIFPDDAVDSEVLLKNADLAMFRSKAEGRNNYHFYVAEMDAEIQ
ARKVVEHDLRVALGTDQLEMHYQPLIEMKTGEVVGCEALIRWKHPTRGWVSPVEFIPIAERTDLIVPLGRWILHRSCLQGRDWARAGLPPQKIAVNLSPV
QFKNHALLAMIADILDQTGFPPDQLQLEITEGIAMQNVEATVDVLRQLRDMGVLISIDDFGTGYSSLNYLKRFPVDKLKIDRSFVVDIGLHPDNAAVVNA
IVTLGHSLGTRVNVEGVETIEQLDFLKAHGVDEAQGFYFAKALPPDEFARFVREK-----
>tr|H8FN83|H8FN83_PHAMO Uncharacterized protein OS=Phaeospirillum molischianum DSM 120 GN=PHAMO_10246 PE=4 SV=1
-------------------------------------------------------------------------DNYRLSELHNRAIVNNTADAIITFGED
GSIGTYNPAAERIFGYSPSEIVGHD--I--AALIPELAGP-GT---IVTAPYLDHRTEVTGVLKGGARLFLELSLSSMQL--GGQDLFIAIGHDITARKA
NEEELRQQKITINALPDLVCLKDGSGRWLIANRVCLEMVGLRGRDYVGRSARELSR--LTPEHHDTAWREGRTLTFELSMPSS-SGPR--VFD-MTKVPL
FTADGGRRGLVVVGRDITERKLSAARIQHLAHHDSLTELPNRALFQERLRQALAHGRRTKTRLALLFLDLDKFKDVNDTLGHHIGDQLLTAVARRLTRCL
RETDTVARLGGDEFAVILTNLADEGASHVADTIIASLSEPFGLEDHEVLTSTSIGITLYPDDAESADQLLKNADLAMFHSKAQGRNAYHFYVAAMDAEVQ
ARKAIERDMRLALGTDQLELHYQPLLDLKTGEIVGCEALLRWRHPTLGWVPPAHFIPIIERTDLITPLGRWILHRACLQGRTWLRQGLGPMQIAVNLSPV
QFKHSTLLAMIADILDQTGFAPEYLQLEITEGIAMQNVENTIEVLQSLRRMGVLVSIDDFGTGYSSLNYLKRFPVDKLKIDRSFVIDIGQHPDNAAVVKA
IVDLGHSLGTRVNVEGVENRSQLDFLLARGVDEAQGFYFSRAIPADDFAALVRQR-----
>tr|E6QTE2|E6QTE2_9ZZZZ Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) (Modular protein) OS=mine drainage metagenome GN=CARN7_129
-------------------------------------------------------------------------ARNKEQVF-LKQILENSPDGIFTVDFE
LHIRYVNSAFCRLVNYTEQELTGSF--I--TEHLGDIDILC---MKLIEETGECNDQETIFKRRDGSMVHVSKNVRTIKD--ENVTGMLITVRDMSKLHQ
LNKALYLAKVTLASIGDGVITTDVLGRVTFLNPIATNLTGWTLDEAQDKPLSEIFN--IINEVSRSVLRDGKTVTLANHTVLISRQGTEYNIE-DSAAPI
FKADGTLMGCVLVFHDVTEKHRLLNATRWQATHDTLTNLPNRVLLSDRFNHATVRSQRQQNLLAVCIIDLDEFKPVNDRYGHNIGDVLLIEVAKRLTTIV
RGDDTVARLGGDEFVLLLSDVNDDELELIMDRVLASLSMPYFIHNKRITISASIGATLYPLDQSDTDTLLRHADQAMYQAKQRGRNQYNLFDIMLDRQVT
SSHQTLKQIKKALESNAFVLYYQPKVNMRTGVIVGMEALLRWQHPTQGIILPLDFLPQVEQTNLIIDIGVWVMEQAMQQISVWLKAGK-SWVVSINIAAL
HFHSGDFLQHLKDAARYPDVPAHLLEIEILESVALNDINQINQLIRDCQALGVSFSLDDFGTGYSSLSYLKQLPAETIKIDQAFVRDILDDSDDLTVVEA
VINIGKVFHRKIIAEGVETTEHGVLLLRLGCDLAQGFGIARPMPAIQVLNWANAY-----
>tr|A4A7P9|A4A7P9_9GAMM PAS domain protein S-box/diguanylate cyclase (GGDEF) domain protein OS=Congregibacter litoralis KT71 GN=KT71_14029 PE=4 SV=1
-------------------------------------------------------------------------RRAEQESLKRQSILNAISDGIVISDNE
GRIAAVNDGMQRVFGYDIEFLRGKE--T--LLLHNSEEEFITPLLDGEGPTAPKRAYEACYRRGDGSLFTGETIRSLVRD--GNVTGFVTVIRDISQ---
-----RRLTAQFTHAREGILITDDAGKIIEVNEAFEDITGFSRDEAMGKNPSFLSSGQHSAEFYAAMWDELKKNDYWSGEFFNRRKDGSLFVELITISAI
RDANEAVQQYVGLFTDITRMKEHQKQLEHAAKFDSLTDLPNRILLGDRLSMALSQSQRRGSKVAIAYIDLDKFKAINDRLGHAAGDLFLVQLSRQMKTAL
RETDTLARIGGDEFVALIGDVADTECAVLLRRLSEAIKTPVTINGEALSVSASIGVTLYPEDSCDADQLLRHADQAMYAAKQNSSHDLEFFDVSEGYNLD
LRRALLSEVRQALLRQEFRLFYQPKVHLPSGELLGAEALIRWEHPERGLLKPAEFLPDVETSPLSVEIGDWVIAEALSQMNEWLETGL-RVPVSVNVGAM
QLQAPDFTEKLTLAARHEALDPSCLELEILETRALADLEATSRIMKACRRLGVRMALDDFGTGYSSLRYLKFLPAEVLKIDQSFVKGMLSDRDDKTIVMA
IIGLGETFDREVIAEGVETAEHARELLRLGCGRAQGYAIAHPIPASDFAAWVDGW-----
>tr|A8FY98|A8FY98_SHESH Signal transduction protein containing a membrane domain an EAL and a GGDEF domain-like protein OS=Shewanella sediminis (strain
----------------------------------------------------------------------------VNNENLFNSIFNGVTDACIFADSN
RNIVSINQGFELMMGYGIDELEGKT--A--SIIYESDEEYQGRIHFNLAAKEKVTPYEANYRHKDGSIIVGETSRIVIRT--DQILGYVGFIRDVTDRKK
ATTALLKLKASFTHTNQGITITDTSGVIIEVNDAFSAITGYARDEVIGQNPRVLQSGRHSPEFYREMWATLQADGHWTGEIWNKRKNDEIYPEMLTISAV
LDATGKVQNYVALFNDITAIKEHQEQLERIAHYDTLTNLPNRTLLADRLTQSMVQVRRRKSSLAVVFLDLDKFKDVNDAYGHDVGDKLLIVISRRLKEAL
RDIDTLARIGGDEFVAVLMDIEKEDCEPVLERLLEAASGSVTVEGIMLKVSASMGVAIYPQDGIDADQLLRHADQAMYVAKHEGKNCYHLFDTAQNIAMQ
IRHDDLQSMRKALDQSEFVLYYQPKVNMRTGAIIGAEALIRWLSPERGLVGPNEFLPAIENHVISIEVGEWVIDTALGQIAAWQELGL-DIPVSVNVSAL
QLQHDGFVTCLAALEAHPEVAPSSLEIEVLETSLIDDVMQVSATMLACIELGVTFALDDFGTGYSSLTYLRRLPASLIKIDQTFVLDMLTTPDDLAIVEG
VVSLAKSFKHKVIAEGVETIAHGTTLLQTGCELAQGYGIARPMMAKDIPEWSVNW-----
>tr|W0V9T4|W0V9T4_9BURK Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628, complete genome OS=Janthinobacterium agaricidamnosum NBRC 102515 = DS
--------------------------------------------------------------IIPGRQPIQVDTAKEVGNMPLKSAMDLIVGLLIVSDAK
GQFVLWNEKAETSMQMSSEQLRNSS---ISSLFSEQEWQRVAASVDDVLAHGKRMCIEAQLRSGDGCETPYVISGARLTYCGRH--YLCIMALDGTERRR
ERHDLQVRERALHAVSNGIVICRSGGPIEYVNPAFERITGYTLTEVVGRDSRFMAASGLDDAERQKLRIAVEAREEINVVFRNMRKNGEVFWNDLSITPV
PDENGKVSHFIGMINDVTALKQRTAHLEHEVNHDALTGLANRNLLWDRLDQALHVAQRKKSLVATILLDLNKFKFINDTMGHDVGDEVLRVVAKRLQASV
RDSDTVARLSGDEFVLVLADQPSRFTLRMVERVRISLSKPIIYEDQEIPVGAALGVSVFPHDGANAYELMRAADVAMYHSKESGNGDVHFFSPDMKSTTD
AKRALETDMHEALDKNELFLMYQPRMNLTTSRITGIEALLRWRHPERGVLQPSSFLPDAEENGMIIPFGQWVLEQACRMLARLKALGHPDIPLSINSSYR
EFSEKNYVAYIADKLDQFKLAPASLELDMREDQLMRNVNLSKQVAERVRQLGVVLNVDEFGAGSSNLSYLQELPMRHLKITRKSVNDICLSTKTGKLAKT
LIDIGHNLKLEVIAGGVENRLQQDFLLQNGCDAIQGNFYKEPIDETELTQLLDA------
>tr|A0A098U613|A0A098U613_9BURK Diguanylate cyclase OS=Massilia sp. JS1662 GN=IA69_22015 PE=4 SV=1
--------------------------------------------------------------VTTGCAR-GGTEAERVARTPLSAIVDMFPGTFYVLNRD
GRFVLWNRNLEKVTGMTPDELGATR---ALDLIELPQRAPLANGIRDVFDDDGELKLEIDFVSRNGRETPVLLNGTKIRCNGGD--FLFGTGIDVAERRA
HEQQLRLRERALHAASNGIVITRLDHAIEYVNPAFERITGYPANEVIGTDPRFMAAPGMDLTERAQLRDAIAARLGAKVVLRNLRKNGELFWNDLAITPV
QDEHGAVTHYIGVITDVTATMLRTAHLEHEVNHDPLTGLANRNLLWDRLEQALHLAQRHKSLVATVLIDLDNFKTINDTFGHEAGDVVLKVVARRLQASV
RDSDTVARMSGDEFVLILANQPSRFTLRMVERLRQSFAIPVAFNNREIPVGASVGVSLYPHDGATAAELVRAADLAMYHGKGSGRNDVHFFSADMKSTTE
ARRRIELALRDALDHDELFLLYQPRVSVATQRVAGFEALLRWRHPDQGVLSPARFLAEAEESGVIVPIGQRVLDQACAFAARLRAAGYVDVPVTVNVSHR
EYTQPGFLANLADRLTRHRLPARSLQLDLRIDALIRNPALGQELAEQLHTLGVDLSVDGFGAGLCDLGYLQQLAATQVKLAHTTVQALTD---GQAVAKS
LIDIGHNLNMEVVAEAVETRPQLDFLAAHGCDQIQGIWISEPLPAEAAQRMLEE------
>tr|A0A086WFV9|A0A086WFV9_9BURK Diguanylate cyclase OS=Massilia consociata GN=JN27_02835 PE=4 SV=1
--------------------------------------------------------------VVITPSE-SVSEAERVGDTPLSAVVDLLPGTFYALNRE
GRFLLWNHNLERLTEMTPDELAAAQ---VMDMFEPRDRPLAAENIRRVFEEGAEVSMEMNYVSRSGRETPMLVGGARVACNGDQ--YLFGMGIDIAKRRE
KERQLLLSERALHAASNGIVITRCVGIIEYVNPAFERIAGYPAAEAIGHDARFMQAPNFDTHERSQVRLALAERRPVNVVFRNMRKNGEIFWNDLNITPV
RDEHGEVTHFIGILQDVTATKQRTEHLEHEINHDPLTGLANRTLLWDRLDHAVHLAQRHGAMVATVLVDLDNFKTINDTFGHEAGDVVLKVVARRLQAAV
RDSDTVARMSGDEFVLVLVDQPSRFTLRMAERLRRAMTTPVAFGGNEIPVGASLGVALFPQDGATPAELVRAADMAMYHVKGNGG-GVHFYSPEMRSASQ
KRAALADSIRSAIEHDELFLLFQPRMDARSGKVRGFEALLRWRHPKQGVMLPAAFLAEAEESGKMIEIGNWVLDQACAFLQELRQLGYTGLPVSVNVSHR
EYSQHGFIPGIAERMQRYGLPPGSLEIEIPEADLIRNPGLGRDLSAQLREAGVALSLDEFGKGISDLSFLRQLSVRQVKLSKAAVHEIAREG-RSCLAKT
LIDIGHNLDLAVVGEAVETEAQVEFLRSHGCDQLQGQWFSEPLAPEAVRRMLDQ------
>tr|A0A085EVH2|A0A085EVH2_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia sp. LC238 GN=FG94_04560 PE=4 SV=1
--------------------------------------------------------------VLIAPSD-ALSESERVGNTPLSDVVDLLPGTFYAINRD
GRFILWNHNLERMTEMTPDELAAAH---VFEMFEPRERRQAMENFRRVFDEGAEVLMEMNYVSRSGRETPIIVGGARVGCDGDQ--YLFGMGISIAKRRE
KELQLLLRERALHAASNGIVITRCAGIIEYVNPAFERIAGYSALEVIGRDARFMQAPKLDTNERSQVRLALTERRPINVVFRNMRKNGDIFWNDLSITPV
RDEHGEVTHFIGILQDVTATKQRTELLEHEINHDHLTGLANRNLLWDRLEHAVHLAQRHKTMVATILVDLDNFKTINDTFGHEAGDVVLKVVGRRLLSAV
RDSDTVARMSGDEFVLVLVDQPSRFTLRMAERLRRAMTMPVAFGGNEIPVGASLGVALFPQDGATPAELVRSADMAMYHVKGNGG-GVHFYSPEMRLASQ
KRAALADSIRSALEHDELFLLFQPRMDARSGKVRGFEALLRWRHPKNGIMLPAAFLAEAEESGKMIEIGNWVLDQACAFLQELRQLGYTGLPVSVNVSHR
EYSQHGFIAGLAQRMERYALPPGSLEIEIPEADLIRNPGLGRDLSAQLREVGVALSLDEFGKGMSDLSFLRQLAVRQVKLSKAAVHEIACEGDGSRLAKT
LIDIGHNLDLAVVGEAVETEAQVDFLRAHGCDQLQGQWFSEPLLPEAVREMLGR------
>tr|K9D815|K9D815_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia timonae CCUG 45783 GN=HMPREF9710_03971 PE=4 SV=1
--------------------------------------------------------------VI-PATP-ALSDAERLGATALKDVVDLLPGTFYILDRE
GRILMWNHNLERVCEMMPEELATAN---AFDMLDPRDRGEFIDKVHRMFDDNVELEMEVDYVSRSGRETPVLLRGARIDCNGGQ--YLFGMGIDISKRRA
RERQLHLYKRALGAASNGVIIAHNGGPTEYVNPAFERITGYAADEIIGRDPRFMAAPGLDGDERNRMRQALHEQRSVHVVLRNLRKNGELFWNDLNITPV
HDDNGQVTHFVGILVDVTASKQRADRLEHEVNHDSLTGLANRTLLWDRLDHAVHLAQRHQTLVAAVLIDLDNFKTINDTFGHDAGDAVLKVVARRLQATV
RDSDTVARLSGDEFVMVLVDQPSRYTLRMVERVRRALTMPVAFGGSEIPVGASLGVAAFPHDGRTSADLVRAADMAMYRAKNNGG-GVHFYSTEMRSASE
ARAILAGNMKSALDDDELFLLFQPRMDARSGKVRGFEALLRWRHPEHGVMLPAAFLAEAEESGLIVEIGNRVLDRACAFARELRHAGYTALPVAVNVSHR
EYSRPTFIAGIAERMSRYGLPPGALEIEIPEADLIRNPGLGRDLAAQLRDVGAMLSIDQFGRGISDLNFLQQLSVRQVKLSKAAVHNIADHGRGGSLAKA
LIDIGRNLDITVVGEAVETEAQVEFLRSHGCDQMQGQWFSEPLSAEAACRMLAQ------
>tr|W7L8J7|W7L8J7_BACFI PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Bacillus firmus DS1 GN=PBF_08313 PE=4 SV=1
--------------------------------------------------------------AHNKTKQAAIEASLHETNQRLESFLNSTTDAVNITDLN
SNVLYMNSSFEKMYGWKKEELLGKQ---LPDLKDEENKQ-----KRALRRGMSFSSLEAQYIRKDGSLIDVNVTLSPLRDSEQKVA-FAAITRDETLRKK
AEQNLIEQESKYENSTDLIRIISADGIVQYASPSHRTLLGYDPEELEGKPFDINIHPEDLETVRNGFAQSCRNPDHLKLEYRKMNKNGEYICVEAYSSPV
LDKDQNLLHYTVVARDISERKEHEKRLRQYAFYDSLTGAANRRYFQELLNSAVETSRKDHTQIALLYLDCDRFKWVNDSMGHDIGDELLKLFVKRIQSNL
RSSDIVGRVGGDEFVVILSDITSEEVAFIAERLQKSLQKPWCIHEHEFTTTSSIGISLFPLMAADSKELISQADQALFKSKEAGRNTYHFFSSEIERNYS
RLIKLEDGLRQAIDKYHFQLVYQPQVETSTGMTAGFEVLLRYHHPELGAIPPSEFIPICERIGIMDELTCWIILQTGKQYREWLKKGYGPVHFSVNMSPV
SFCSDDFLNTYSTAIRDSGLPPHCLEFEVTEQAIMEDLTVAAVKMAEMKKWGVKLSLDDFGSGYSSLSYFRELPIDKIKIDRLFIQDLEITNSDKAIITS
ILSLAKDLEIEVICEGVENKAQVQFLLESGCRMAQGYYFGKPMPAESIEQKLSP------
>tr|W7LHH8|W7LHH8_BACFI PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Bacillus firmus DS1 GN=PBF_08378 PE=4 SV=1
--------------------------------------------------------------VKDITAKINMQNELYETVEQLEALFNSSHDAIDIVNID
RTVKYVNPAFEKMFGWKKEEIIGEL---LPNTLEESERM-----RERLLKGEYINDYEAVFQRKDGTLIDICVNLFPLLNTNNEIG-IAAITRDISEQKR
IKKSLTEKEEKYEYSTDLIRLVNEEKIIIYASPSHANMLGFNPAEMLGKELSHFIASEDLHIFHRRFKNGIEEKKKDSIEFRMKKKDGSTVWVQTKTVPV
FNEEGVFQHFISSSRDISAQKGYEEELKQMAFYDILTGIPNRRLFYDRLSHSIRSAGRNNHHFALLLLDCDRFKWVNDTFGHDTGDELLKKFVRRAESCI
RQSDTIARLGGDEFAIILDRFDTQDVGRIANRLIKSLQKPWIIKGREFTTTSSIGISIYPNDGGTMEQLITKADQALYQSKEKGRNQYHFYTSELASEIE
RTIQLEDELKKAIDSDYFHLVYQPQVNIAENKMAGAEVLLRFTHPVLGSISPVEFIPLCEKIGIIDEVTYWVMRAAFKQQKDWEAQGYS-VPLAINISPA
TLEKKSFLNIARDILREFGTDPHMIEFELTEDTLLHDMESISFILEELQELGIRVSLDDFGTGYSSLKYMKELPIHKIKIDRSFMIGL--PNGERAIFEG
IFLLTKRLGAEVLCEGVETQKQLLFLQKQGCRLVQGYYYSKPLKKEEFNEMLRK------
>tr|A0A074M4R8|A0A074M4R8_9BACL Uncharacterized protein OS=Tumebacillus flagellatus GN=EL26_23265 PE=4 SV=1
--------------------------------------------------------------GRDTTERHAMIQDLLEKEALYSSIMEGSPIAISLNQ-A
GNVVVLNDATLEMLGVKPGNLLGRS---IVDFIAKM--Q-----ANAHVKGRR-EYAEEWIYRMDGRLMPVHAVVSPVTYKGKPAH-I--FIKSRTEIKQ
VEEELSRSEAKYENTSDLISLIDTGGIVHYASPSHEALLGYPVDQLIGQKGASIIAPEDVRTSIESFHRCVQERRPVVMEFRCVTKNGDLAIFEGKCSPI
YDDEGNISRIMVVSRDITERKRQERLISHMAYYDALTELPNRTLFRDHLRTALKQRA-EDEIVAILFLDLDHFKHVNDTMGHSVGDMLLKMMAGRLQDSL
PDAMSYSRNSGDEFVVLLTGVKDEQVEEAARKVVDAIHAPFALGGQLLYLTGSIGIVLAPEHGEDPETMLQHADIAMYDAKDKGKNNYRFFDYILTERMA
KRVELERSMRTALENDEFALYYQPLVDAQSGRVVGAEALIRWFRPGHGMVSPAEFIPIAEETGLIVDIGDWVIRTACQHQQAWRNNGFAPIHLSVNLSTR
QFQEPNFLDRVRRVVEETGVDLNGIGFEITESLIMQDVDYAIKMLNELRSMGSIISIDDFGTGYSSLAYLKKFPIDKLKVDRTFVRDI--TTRDAAITKT
IITLAKSLHLKVVAEGVETEEQIEKLRELQCDEFQGFYFSKPVPVQDFTMMLTP------
>tr|W7QEH6|W7QEH6_9ALTE PAS/PAC sensors-containing diguanylate cyclase/phosphodiesterase OS=Catenovulum agarivorans DS-2 GN=DS2_08605 PE=4 SV=1
--------------------------------------------------------------RNVTQYRQAQ-TALEQIELTNQALIENAPEAIVLFDPS
GKILQANTKSQAIFGLTGQSIFDYS---IQDLLAEQDGKLLLELAN----SCLAPMAEVKIKHASGALIDCELRLVAIQWQGRSLASL----LDIRARKQ
AQSKMRQLSSALEQSADMVLITNRQGTIEYVNQATTLITGYNQAELIGQQPDIFNSGQHDKTFIKNLWSTILKGKAYRDVLVNRKKNGDIYYEEKTITPL
KNDQGEITHFVSTGKDITERMEIQANLRHLAFHDVLTDLPNRALFNDRLKTGLLNTKRRRQQMALLFFDIDHFKRINDTLGHDIGDVLLQQVAKKLKKGL
RGSDTVARLGGDEFAVILNDCQDNAIRHTAEKIIELINKPVKLADRELFVTTSIGIAVYPQDGTDSQALLKNADVAMYRAKSSGRNTYMFYRQEMNAHAF
ERLTLESELHRAIQQQEFVLYYQPKVCLQTGLILGVEALLRWRHPELGILLPEKFIPLLEDTGLIVPVGQWVIEQALADCNQWYEQGLEHIKMAVNLSPN
QLKDVKFIEGLQNALAQHQLSTSCLELEITENTMMADGEKAFVLMQQLQQIGIKFSVDDFGTGYSSLAYLKRLPVETIKIDRSFIQDIGIEQEDEIIVKT
VIAMAKSLGYRVVAEGVENLEQVNFLKSLNCDIAQGFLFSRPIPSAELVSHLQD------
>tr|A0A081G204|A0A081G204_9ALTE Diguanylate cyclase OS=Marinobacterium sp. AK27 GN=ADIMK_1262 PE=4 SV=1
--------------------------------------------------------------QDNTDKRLAE-EKLARREQAFRTLTHNLPDTVLRMDRQ
GELLYANPAMQRLL---PQPVSDQQ---VRNLEQTMNG--LKEQARRIAKTAKATEMDMVFAAPDGHRRHFAMRIVPEP--DADGGSVLAVGRDLTELKR
AEEELRLAASVFHASAEGVMITDASGRIISTNPAFTEITGYGAAEALGRKPSMLKSEHQKADFYREMWDALLTEGQWQGELWNRRKGGQAFLEWLTINRI
DDSLGNPVRYVAVFHDITELRRKDEHIEHLAFHDALTGLPNRELLLERLGHALAQSHRENKRLSVTFIDLDRFKGINDALGHDMGDNLLQQVGDRIRRCL
RTTDTVARVGGDEFLVLMENLTSRDCATKAQQLLDEIARPIALPGYRLEITASMGMAFFPEDSNQPLELMKRADMAMYAAKEAGGNTYRFFRQEMLERTT
RRLTLEMDLRRAISNNELELHYQPKIDLASNTVTGVEALLRWRHPTRGMQAPGEFIPLAEENALICDIGAWVIGEACRQTAIWRAQGLD-LKVAINISAR
QLETGDLYQQLCALAHQRGIPPSSLELELTESALMKNPEGVTGLLNQFRQAGVRIAVDDFGTGYSSLAYLRRLPIDILKIDRSFVLDAIADEDDAQIIKT
ILALGQSLKLAVVAEGVESESQAALLKASGCDQAQGYLYAKPLPGDDIEAWLTQ------
>tr|K9ES26|K9ES26_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Leptolyngbya sp. PCC 7375 GN=Lepto7375DRAFT_2000 PE=4
--------------------------------------------------------------GNLLTGPHAIETQAAAEICLLTHVLQSIHDGVYMATEE
GALLFLNQSLRQLCTHPAKPTLGQT---SDQLLSQGN-------QNRQTQKNSTFKTELSLESSIGLDRTVLLSESWVKAQQQT--LRFGMIHDITERKQ
AELER---DRFFNLAIDLLFIADADGVFKRINPSWFDTLGYTADDVLSQSFWQFMLPEDQHSKQDLQDTLAQGQEINGLEFQVRSKDGDYHWIAWNLVPF
PQED----LLYGSGRDITQRKASAARLTYETLHDSLTGLDNRVCCLNRLELAIEHQKRPHEHFAVLFVDLDNFKYINDSLGHLVGDQLLIQVSQRLKAVV
RGIDGVARLGGDEFLILLEQLDHNDALKTVYRLQKELQKPFQLGGREIFTSASIGVVFSNLSYQSVDDIIRDADIAMYRAKSEGKSSYAIFDQTMYLQTL
HLVEIETDLRKAIKAQEFCLYYQPLVNLKPHQLKGFEVLLRWHHPDQGLIPASEFIPIAEETGQINAIDEWVLRNACKQLKTWQAKGKVTVYLSVNLSGQ
QFRNPSLIYTLDTILTETQLDPQCLKLEITESSLIQNTQAATEIMKLICNRGIELSLDDFGTGFSSLRYLQQFPISTIKIDRSFVDGLNN--SNFRITSA
IVNLAKALGFNTIAEGVEAHEQLTELHELGCDAGQGYLFSKPLPATKVESYLAQ------
>tr|T2RV22|T2RV22_SACER Diguanylate phosphodiesterase OS=Saccharopolyspora erythraea D GN=N599_22270 PE=4 SV=1
-----------------------------------------------------------------------------DTDQPVGPLGRALRDAVFTLDPD
GLVTSWNLGAELIIGATASEVIGRS---AAVFHTAEQRA-EGHPEEQARKLGSHVDE-GWRVRKDGSLFWAHVVTTALWSSKGELRGYAKVARDDTVHNK
LSRRLEQSSDLFSLTPVALGLFDRHGTVLDCNMAMCELFGHLPERLRGSHATALIPQD-APAREQLVEAFARGVPPDGEECRLVRSDGEPVFCELHIARA
EEDSGEP-FWVVVFEDVTDRYREAESLRYWAYHDELTGLWNRAAIPDLLAD----A--HPDRAAVLYCDIRNFSRVNESLGYPAGDEVLVALARRLEEHL
PEGWPVARAAGDEFAVICPDVEEGGIAAVATTVSRVMHAAIEVRGERIQVSSMIGAAVASESGGRGEDLVRLAMSALVRAKKTGRVGISMAEPALIDSLE
GRLRLEAELRRALDRDELTLHYQPQVG-ADGTIRSAEALIRWPHPQRGLLHPDVFLPIADQNGMMPDIDRWVVRRALRDAARWPAPRDEPVAVSLNIGEL
MPGYPIFTDLLERAVTETGIDWSRIIVELVETAIVDLPSRVRAGMAELTGRGVRFAVDDFGTGYSSLSRVRDFPAQIIKVDRTFVSEITTSPYDFVVVKA
VTDLAGALGCSCVAEGVETVGQFDRLRSIPIERYQGWLFSKAVPSAELADLIEAGP----
>tr|A0A099D256|A0A099D256_9ACTO Diguanylate phosphodiesterase OS=Actinopolyspora erythraea GN=IL38_20040 PE=4 SV=1
-----------------------------------------------------------------------------DAEELIGRFGASLWEAVYTLDPE
GTVSTWNPGAERITGAAAAEVVGRN---ISVFYTAEQLA-AGYPGERAARLGSYTDE-GWRVRRDGTRFWAHVTTIALWSSRGTLQGFARVTRDDTSHSR
L----ERSLDLFGLTPVGIGVFDRHGHVFDSNPALRELFGYGEDEMRGVHIADMLHPD-EPDRQSLLREFRGGEPPEDDEWSMIRADGRRVLCELHVAKS
VRDTGES-FWLAVFLDVTERHRRAEEWHYWATHDSLTDLPNRTAVHELLSG----A--DMRGLAMLYCDITNFRRINESLGLRAGDELLIEMAKRMRSDL
PREWLAARMAADEYLIVCPEPEEGGVDAIAETVGELFHRPVYLRGHPIQVSASIGIAVGDDATG-ADDLLRSAGAAVMEAKSNERRRIAVAGPTLISAMD
RQMELESELRTAIGSDQLTLHYQPIVR-ATGVIVAAEALVRWNHPERGLLGPDTFLPVAERADLLGELDRCVLRTAMRDTSEWPVKPDNQAAVSINLAEL
SPGDPGFVATLDVASAETGLRQNRVVVELLETSLINLSERGRDTMSELTGRGLRFAVDDFGTGYSSLARLRELPIDVIKIDRGFVRDVVTTRADLMVVKA
IVDLAKAIGCTCTAEGVETVEQFELLRGVGVHTYQGWLFAPAVSAAKLRELLASGT----
>tr|A4FEG3|A4FEG3_SACEN Saccharopolyspora erythraea NRRL2338 complete genome OS=Saccharopolyspora erythraea (strain NRRL 23338) GN=SACE_3161 PE=4 SV=1
-----------------------------------------------------------------------------ARREASRPAEAGPGTAVYSLDAE
GRVASWNPDAQRLKGYRSEEILGRH---FSVFYPPELAA-VGYPQERAAEAGVHIDE-GWRIRKDGTRFWAYLIIAARRSEQGVLQGFVKVVRDDSAHAR
Q----QRSYDLLALAPVGVCFVDDNDRVREVNNALCRLVRHPRAEVLEMTGADLLHPR-DGGGG-LTSENALSEEEETPSRVLLRSDGEPIHCDVYSALS
VQDDGSH-FWLVVFQDVTERIHQAEALQHQLTHDALTGLPNRRGVDELLD--------NAGRLAVLFCDIDNFKRINDSLGHAAGDELIVTVAQRLRGEL
GEECAVARLSGDEFLIASTDVDAGGLRVLADRVAGMLRMVVPVRGHLVRVSASVGAAMFPESGTSGEDLLRFADAAMFRAKRHGPGRVVLADPELTASLA
EQMGLEEQLGEALRTDGLRLHYQPIVD-RDRTVVSAEALVRWPHPRMGLLSPDVILPIAEQGNLLHELDLWVLRAALRDAVGWPRQARRPVRVSVNLSGR
FSAEVDFLDAVGAILADSGIDLHRVVLEVTETSLVELSAAARDAMHALIRLGVSFAVDDFGTGYSSLARLKDLPAQVIKLDRQFISGLETQEADRAIVRS
AIDMAHATDRRCVAEGVETAAQYHLLNELGVDAHQGWLFSRPLPQADFRAVVAGGP----
>tr|A0A073B281|A0A073B281_9PSEU Diguanylate phosphodiesterase OS=Saccharopolyspora rectivirgula GN=GU90_04675 PE=4 SV=1
-----------------------------------------------------------------------------NSQVAKVLAAEDMREAIFSLDAT
GRVTSWNNGAARIKGYSTEEIVGRH---FSVFYPPEVVE-AGYPEGQAAENGFFIDE-GWRTRKDGSRFWAHVVLVAQRATDGALAGFVKVTRDQNAVIR
K----ERLEDLFELTPVGVAMLDELGTVLDANGSLCDLLHCRLHQLRGRPVSELLHVS-DPGGP-FVPIPDSAEALSTGRVLARVDDGQPIIVQVNRTTT
VQEEGKR-FWLVAVQDVTQRVREAEYLQYQATHDETTGLLNRNGVRRLLSPLPSAQ--FVNRIAVFAADLDNFKRVNDSLGHEGGDELLSALAQRLTNGL
PPTCTPARFYGDEFLVVCSDVQEGGMRALTAQIAKILHTVVPVRGRLIKVSASIGAAVVENDRTTGEELVRYADAAMFEAKQRGQGFVERADPVLASTAA
SQLTLEEQLRHAIHNDSITMHYQPIVD-NDGSVVLAEALLRWSPKDEAPLPPPQVLRVAAQGDLLRDLDRRILRTALREASHWTG-PDEPISISVNLGGL
RPDMPGFDEEILAAISESGAKPEQVVLEVVETTLAELPETAQQAMSELTRIGVRFAMDDFGTGYSSLARLKDMNTQILKLDRKFVSGIGTDPMDLGITRA
MVELAHTMGRECIAEGVEDADQHRLLQDIGVDAYQGYLFSKPLPPAEFKEFVQAAN----
>tr|A4FHW4|A4FHW4_SACEN Saccharopolyspora erythraea NRRL2338 complete genome OS=Saccharopolyspora erythraea (strain NRRL 23338) GN=SACE_4370 PE=4 SV=1
-----------------------------------------------------------------------------QASAAKVLAAEDMREAIFSLDAS
GRVASWNAGAQRVKGYRSEEIIGKD---FSVFYPHELAE-SGYPQEQAAQDGFFIDR-GWRVRKDGSRFWAHVVITAQRSPDGVLDGFIKVTRDESAQVR
E----HSSRDLFELASTGIALFDDAGRLLDANVALTDLLACPLPQLRDKMDRDFLHPS-DEGNGGLLPSTSPLRSPVGGHRVLTTSEGEPVLCQVHSKAS
VDAEGGR-SWLAIFHDVTEQVRRTEVLSFQATHDGTTGLLNRRGFEEVLSSLLSPE--ADGEVAVLFCDLDNFKRVNDALGHEAGDELLAAVADRLTTEL
PPKCTAARFYADQFVIVCPDVDAGGSDALTKHVGNVFRMVVPLREWRVHVSASVGSTVVEDHGTSITEILRLAEAAMIENRFRSHGRLQLVQSRPAEPHT
DQLTLEHHLREALADDRIDLHYQPIID-NDGAVVMAEALLRWSDPELGPVTPDVALGVAERGGLLTGLDRCVLRKALHTSVGLRR-PDRPIAVAVNLSGL
HPDRPEFVEEVLAAVDEAGADPENLVLEMVETVLAELGPTPQRAVRRLVDAGVRFAMDDFGTGYSSLARLRELPTQILKLDRLFVGQVCFDPANLGITRA
VAELARTMRRQCIAEGVENATQHHLLRAIGIDAYQGYYFSPPLPPDDFRDFLATTP----
>tr|F5REA7|F5REA7_METUF Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor S OS=Methyloversatilis universalis (strain ATCC BAA-1314 / JC
-----------------------------------------------------------------------------GAPEHFRAIFESSDDAIVSKTLD
GRITSWNAGATRMFGYSEQDMLHQP---MLRLFPPERVA-------------KVDHYETERLHRDGRRIHVSVSVSPVR-DAGRIIGASK-ARDITAQKD
A-----------SHTSEGIVIVDPHGRIVDVNEAFCRITGFERPQIIGRTPDMFASS---PAEFEIILNAL-----AQT----RRQDGESFASLVKISAV
RNEQGQTQNYVVLVSDVTPLRRQQETLEHLAHFDALTDLPNRLLLSDRLVQAINASRS-DDWVAVLYLDLDGFKAVNDRLGHDAGDELLVLLARRVSSQL
RETDTLARMGGDEFVAVLVGLRNNECVQLVDRVLRVCTEPFFVKGESVQVSASIGVALYPQDN-DAEQLIRHADRAMYEAKQAGKNRYHLFDPDLHERAR
SRSEQLEDIARGLRCGEFELFYQPKVNMRSGQVIGVEALIRWRHPQRGLLSPAAFLPQTEGHQLAAELDRWVLDQALNRMAVWRAQ--DALTVSVNLNGR
NLQQRGFAEALAATLASHDAPPERLELELLETSALDDINDVAVVMQDCHRLGVRFAVDDFGTGYSSLVYLKRLPAETIKIDCSFVRDMLADRDDRAIVQG
IVGLAHAFGRELIAEGVETVAHGCALLAMGCEQGQGFGIARPMPAEDLAAWIAGWQ----
>tr|L0DWX8|L0DWX8_THIND Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Thioalkalivibrio nitratireducens (strain 
------------------------------------------------------------------------------GESRQRAVFAALGEGVYGTNAD
FECTFVNPAALKMLGFT-EEVIGRD---PHTLF--------HYQC-------RTRHEEGWLLRKDGTGFPADMIVTPMVEA-GHVTGAVV-FSDISERKA
A-----------DQSPESIVITDLDGRIKYVNQACVNKSGYSRVELLGANPRVFQSGR--PETYRKMWDTV-----TSG----RNKHGHEYTELATLAPV
RDHNGRISHFLALKQDISELKHAEAEVHRLANYDRLTELPNRSLLMDRLAQTLASSSH-PQRSALILCNIDRFKILNEARGQASGDLLLKAVARRLDTLV
RESDTVARLGADEFAILLQNLDPQGAFSVAEKIHLALRHPFTLDQDVVNITASIGITLWPEDAGTPQEILRRADTALHKAKRAGGNQSAFFEAGMGEVAQ
LRFHLERELREGIPAGQLRLFLQPQVD-AEGQIVGFEALVRWQHPGRGLLLPNAFIPVAEESDLIVEIGVWVLTETCELIARE-K-A-RPLRIAVNISPR
HFKEAHFVPWVRDLIAATGIDGHSLTMEVTEGLMIDNFDDVIARMSALQELGIHFSVDDFGTGYSSLSYLKRLPIHELKIDKGFIQDAPTDPEDAALVET
ILNVAKDLGLTVVAEGVETAEQAAFLNSRARAVHQGHFYGRPEPAEAWLERTATLS----
>tr|Q607V4|Q607V4_METCA Sensory box protein/GGDEF domain protein OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN=MCA1650 PE=4 S
-----------------------------------------------------------------------------QAEQRLRMLIDAEPECVKTVGAD
GTLLDMNRAGLQMIEAEIEEVRGKP---ITSLVAPQ-DV-ERFKA-------GLKGGRRWLESH---------AVPFASRP-GAPDAVLA-TRDVTERKL
A-----------FETSEAIMITDAAGIVQRVNSGYSAITGYTSDEIVGTPSEFLHPGG--KTSPRAILEAL-----KGT----RRKNGDVCPVWLSIKAV
RNDEQILTHYVVTFVDISERKRAQQEIEQLAYFDPLTGLPNRRLFLERLNQAIGESCN-GSRCSLLFVDLDRFKHLNDARGHTVGDQLLRKVAERLSEGV
GRGGMVARLGGDEFVILLNGLDEFETMDVAENLRVILQRPFVLSSGQHYVTASIGTAIYPFDT-SADDLLKAADMAMYEAKASGRNTVRAYASTMQAAAE
TRLTLERDMHAALERREFRLYLQSQVD-GNGRIVGAEALLRWEHPTEGILLPDKFIALAEETGLILPIGEWVFEQVCHENVRL-S-Q-HRLSLSVNISPR
RFQQADFLDHVQRILKRTGANPHDLIFEITEGLLVSDFDDAIAKMSFLERLGIRFSVDDFGTGYSSLAYLKRLPLSELKIAQTFVNDLPDDPSDVALVQT
ILSMAYHLNLETVAEGVETRAQLEFLKARGCTRFQGYYFSPPLPATEFFEKLA-------
>tr|A0A081BTZ6|A0A081BTZ6_9BACT Sensory box/GGDEF family protein OS=bacterium UASB270 GN=U27_02760 PE=4 SV=1
-----------------------------------------------------------------------------------------------ITDLD
GKIIYANQAQADIYGYQVAALLAQL---MQ---ILLPYE-RRKPLGLIREEWTYRQHLEELVIGHTTELR------------TTNR-----QHKIAEHLC
I----RKSEIVLETVPDPIVVYDAENKIDYLNPAFSRIFHWTLAECKGQSFYFTP---P-IHA---LFEEI-----KGG--RLTRE-NNTLQVSLSGAGF
FDPNGKLQGSVITMQDMTERKKTEEEMKFLAYHDALTGLPNRKAFNMRLHYELAPSAFPQHQWALLFLDLDRFKFVNDTLGHYIGDEMLQLIANRLHTCL
RKSDYIFRFDGDEFTIILNTINDTDVARVAQKIRDEIARPYSIHGHELYITASIGISLYPNDGDNGETLLQNADMAMYSAKEEGQ-GYRFFTEEMNQKAF
ERMRLENSLRCALQQDQFLVYYQPVADH-NNQVIGMEALLRWNHPNLGWISPTQFIPIAEETGVIIPLGKWVLQAACTQAQKWHDMGYPDFSISVNLSTR
QFREPDLTEMIEQVLAETHLAPNRLKLEVTESGIMDNPDDAIAKMHILRAKGIHFSIDDFGTGYSSLSYLKRLPIDILKIDRSFVMDAPTDKDDQEIIKT
IIAMAHNLRLDTIAEGVETREQQQFLARNGCRMMQGFYFGHPMPADQFEARLCSTL----
>tr|A0A099JEJ6|A0A099JEJ6_9MICO Uncharacterized protein OS=Cryobacterium roopkundense GN=GY21_09320 PE=4 SV=1
-----------------------------------------------------------------------------VSAQDIPLLVESAPDAMVVTNSH
GEIVLVNAQAERLFGYPREELLGEN---IEMLIPARLRR-HH----------MASTLSIHAEHKNGSEFPVEVSLSPLSTAGGVLVSS---IRDISDRQR
VVAKLNLAELGFDRSLIGMAIVDVAGRFLRVNPATCELLGRDQDGILGHSLSDFLDQD--PAQ-----RLL-----VGA----VRPGGEILWVEETIFSV
PHADPASPTSFVQLRNITGRRQAEQLLEFQSLHDPLTGLANRRLLASTLEDSLARARS-GCPVGVLFFDLDKLKQINDAYGRTVGDRIVLELVRRMHSIV
RATDILARFGGGEFVIVCENLTWNT-QRLVDRIVRLDTEPFVIQGRDIFMTVSVGIVVAEGH--NVADVLSNSESAMYQAMTSGRGQSSLYAAETHQASS
DRFKLELELARALDNGELRVFYQPIIELSTRDVSGFEALIRWHHPTRGLIPPMDFIPIAEESGLIVPIGQWVLREAAAQAMRWLEME-RGLTMAVNLSIV
QLRDPGLLGNVLEVLTKTGLDPHSLHLEITESMVIHDFETALDTLHALHALGVQLSVDDFGTGYAALGYLRTMPVQTLKIDKSFIDPLVGHPRSLSIVEA
IVSLARALDLDVIAEGVESVEQMVELQRIGTHLCQGYLFSRPLPAEEIPSWLREFR----
>tr|A0A086DZ98|A0A086DZ98_9MICO Uncharacterized protein OS=Cryobacterium sp. MLB-32 GN=JF66_09095 PE=4 SV=1
----------------------------------------------------------------------------------------------MVTNSH
GQIVLVNVRTERLFGYSREELLGES---IEMLIPGRLRT-HH----------LQSGLDIVAEHKNGSEFPVEVSLSPVETAGGSLICS---IRDVSDRRR
LVAKMNIAELGFDRSLIGIAVVDSAGRFLRVNPAACELLGRAQDQLLGGLMSDFLEQE--LLP-----HQR-----DEF----VLPGGEILWVEETIFSV
PHADPESPVSFVQLRNVTGRRKAEQLLEFQSLHDPLTGLANRRLLASNLEDSLARARS-GCPVGVLFFDLDKLKQINDAYGRPVGDRIVLELVRRMHSIV
RATDTLARFGGGEFVIVCENLTWNT-QRLVNRIVRLDTEPFVIQGRDIFVTVSVGIVVADGH--DVATVLSNSESAMYEAMTTGRGKSSLYAAETHQASS
DRFRLELELARALENGELRVFYQPIVELSTRDVAGFEALVRWEHPTRGLIPPMDFIPIAEESGLIVPIGRWVLREAAAQAMHWRATE--NLTMAVNLSIV
QLRDPTLVGDVLDVLTTTGLDPQSLHLEITESMVINDVESAMNTLHALHALGVQLSVDDFGTGYAALGYLRTMPVHTLKIDKSFIDPLVGNPRSLAIVQA
VVSLARALDLDVVAEGVESVEQMVELQRIGTHLCQGYLFSRPLPPDEIYAWLGEFR----
>tr|D8MM19|D8MM19_ERWBE Strain Eb661 complete chromosome OS=Erwinia billingiae (strain Eb661) GN=EbC_03720 PE=4 SV=1
-----------------------------------------------------------------------------EREQVFRLLVEGVTDAIYMLDPN
GLVVNWNAGARRAKGYSADEIVGKH---FSCFYSAQDRL-AR--LKLAETSG-RFDDEGWRYRKDGSAFWAHVVIDAIHNDSGQLIGYAK-TRDCTEVRE
YSARTASLSTIIANIPSSVIVEDVSREILLMNNKAEQLLGLTQQQMSGKKLAACLTSEM--DYFTQLSTAAQR---FEG--QLLNTRGGERIISATASII
RGND-ARTYVLLIADDVTDQRAADARIHHMAHHDNLTSLPNRVLFSQRLNEALRADREAGKLTATLGLDLDNFKNVNDALGHQVGDDLLRAVASRLRGVL
RDVDTLARNGGDEFSIVLPGLTHQEADAIAHRLIEVTKLPFNVDGHNLSVGLSIGIAIGGREL-TPEQLLRCADMALYEAKRNGRNRFEHFSVQMGEAAN
LRRMIENDLRDAITHKHLRLYYQPITNNHGREIIGYEALMRWHHPEKGLIMPMDFIPIAEETGLIHSLGAYALYEACREAANWPAH----QSVAVNLSPL
QFKNSSLVSVVEAALKESGLEPGRLEVEITESVLLDNTLVNIRTLQKLKALGVRIALDDFGTGYSSLSYLRSFPFDKIKIDKSFINDMKDSREALAIIRA
ITGMSRSLDIQITAEGVESNEQFEQLKSEGCTLFQGYFFGRPQPPETRLKVFNPPE----
>tr|A8TVS6|A8TVS6_9PROT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=alpha proteobacterium BAL199 GN=BAL199_20470 PE=4 SV=1
-----------------------------------------------------------------------------ARYTSLLRGTLENISGLCAFDRD
YRLITWNARYFELLDLPPAYAVGTP---MIDIIRFL------------AKRGTRGQLLEVRIR----PLAD-----------GGLV-----YSDVTERGK
A----RESELAAAGANDGLWDWNLGSNRIFFSDRWKQMLGYATDEIEDGAEEWFS---R-QRVTAQIDAHL-----GTA--RVRHFDDTYRWMLVRGLAV
RDGENNAYRIAGSMTDVTERKRAEEQAIHDALHDSLTGLANRTLFLERVRQALARQRSLSAQFAVIYLDLDRFKVVNESLGHVHGDDLIIAAARRLEQNL
KFGDTVARLGGDEFAIMLEDVHDEEGTALSEMLQKALSTPFVLGGKEVFTTASMGIAHSTDNYVRPEDILRDSELAMYRAKELGKARSVAFDPAMRGTTV
TPLDVETDLRRALDRNEMILNFQPIVSLADGRIRGFEALSRWRHKERGDIPPSEFIPIAEETGMIVELGQWVLRNACAQMVEWNKEPDGPFEISVNLSGR
QFTQLDLVKMVTNSLDGTGLDASFLKLEITESALMENAQRSAQMLRHLKDLHIKVCVDDFGTGYSSLSYLHKFPIDTLKIDKSFVQDMGRNRHNLEIVRT
IAVLAQNLRLDVIAEGVETPEQLAQLRAIGCGYAQGFLFSRPLTADNVRHLLAENR----
>tr|A0A086DVA6|A0A086DVA6_9MICO Uncharacterized protein OS=Cryobacterium sp. MLB-32 GN=JF66_19100 PE=4 SV=1
-----------------------------------------------------------------------------ENARLLAAIVENANDAVIATTLD
GIVTTWNAAAQSSYGYSREEMVGTS---IDRLSSESRMD-------------NIDRFETVRIRKDGTLVQVVLTVSPIRDDDGIAVGAST-ARDVTAARQ
A-----------ESSLDSLVAISPEGLITDVNEATVKATGIPRVELIGTAFSDCFTEP--EAIYQLVFEK--------G----RHRDGTLTEVLYNASVY
RDVGGNVLGVFAAARDVTEVRRAQEAVAYQAFHDPLTGLHNRAWILDILAADLRAAQW-DHPLGVLFVDIDRLKTVNDSLGHAAGDELLTTVAHRMVAAL
RAGDRIGRFGGDEFVIVLQDMQDQDALSCAERVSSSISADMHVRGHRIVPSVSIGIATSTST--TSGSLLRDADVALFQAKAAGRARWHFFDDAMHGQAL
ARLTLEDELREAIAHHQFVVYYQPIVALADARVVGHEALVRWAHPSRGLLSPAEFLDIAEDTGLISAIGAQVLDQVCALLAERP----LPGPVSVNVSAV
QLSEPTWLASVRETLTAHHVSPARVVIEVTETAVLSLVGSAQVALAELRGLGVGIHLDDFGTGYSSISVLRELPVTGVKLDLRFVQDLTEGSRANALAQG
VSGLVKGLHLTGIAEGIETQVQADILRAQGWECGQGYLFGRPGPSPACRVPA--------
>tr|D5AKS8|D5AKS8_RHOCB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
-----------------------------------------------------------------------------DRVGRLHAAVIEYSNAILTHTLD
GIVTTWNPAATVMLGYLAHE---RI---GRPVNDGAEV--------------AVEHFETRMRTRDGRVIDVSITLSPIRDPSGAIVGIST-LRDITETMQ
IQS-----EFALEAARAGWQ-WHCLEDRVICSERFLQQHGLDPAAGPVTLA-----GWL---VRALVLGALESGGAYRV---------GPRWIEAFG-RI
ERDAAGRARVNGISFDVTDRFEAVERIAYLAHHDGLTGLPNRALFLDRLEAALGRVRHARG-CAVLLIDLDRFKEVNETLGHAAGDRLLCAVAARLRAEV
SAADTLARLGGDEFAVLLTETEAQTVSALAERLIAAIEAEFDLDGRRIGIGASLGIAMAPSDG-SPKALVKAADVALCRAKADGSGCLRFFAPESDSRMQ
QRRALESDLRRAWAARDFQLFFQPIVEMKTRRVSCLEALLRWHHPERGWVSPETFIPLAEEMGLIVPIGEWVLTEACAAAARWPGS----LRVAVNLSPV
QLAHIGLAEAIAAALRRTGLAANRLELEITETVMMKETPATLATLERLKGIGLRIAMDDFGAGYSSLRNLQRFPFDKVKIDRAFTAGLGTSQQSAAIVRA
VTGMCQSLGMVSTAEGVETETQLAALAREGCSEVQGYLFSKPVPAAQVGALLARLD----
>tr|C7Q7Q8|C7Q7Q8_CATAD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBR
-----------------------------------------------------------------------------CA-------------MIFFKDRE
SRFLRVSDSAAEFSGTDPASMIGKT---VRDYFTPEH---AAAAFSTGRALT---------------------------------------SRDITARKI
STAELDRVGTLLDTSPDLMARFDRDLRCTYANPAAREITGVEM---LGRTSRQRG---Y-GVWEESLRQVL-----TGR----VTVGGQYRFLHTRFVPE
LDADGEVTSVLSVSRDLTDRRRIEEALAEQAVRDPLTGLANRTLLVSRISEAIEYSGGADDRLAVLFLDLDRFKLVNDSLGHAAGDELLAAVADRLRKAV
RRGDLVARFGGDEFVVLCENVAGAEAASIAQRVIDCLIRPFDCAGKPMHVRTSIGIALAHGPDTTVDELLRDADAAMYQAKSDGAGGYRFFEPATHERAV
HRMNLEQDLRQAVERGEFTLVYQPIVALDDGRVTGAEALIRWRHPERGLLTPAAFLEVAEETQLIVPIGRWVLDEACRQLAAWNAMPPRLPLLAVNLSSR
QLSHDDLVTQVAKAIARHGVPAGRICLEVTETAVHEASLTARSALAAFSAAGMKIALDDYGTGYSSLGHLRDNPVDTLKIDRVFISGLTRNRGDDAIVVA
VITLAHALGMRVVAEGVETPEQRERLRELGCDFAQGHLFAMPLCAEEFGELLRSGA----
>tr|C4XM09|C4XM09_DESMR Putative signaling protein OS=Desulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1) GN=DMR_36460 PE=4 SV=1
-----------------------------------------------------------------------------ESEKRFRTIFDSASDCIFIHDKT
GKIVDVNSRTCKVFRYAREEILALD---VGKISSGIY---------------DMLSFEWQCKTKDGQVFWGQVCTSVATIN-GDV-QVIV-LQDISEHKR
A-----------ESVPGLLYLYNDEGLLIRWNKQHETITGYSGQELAQMHLLDWYKGD--QKKITSAINRV-----VKD----QTKTGARIPFYFTAVS-
-LEIEGKLYFVGTGIDITEQKKLEQQLLFRALHDPLTGLANRVLCMDRISQASERLSNPNHEFAVVFIDLNNFKSINDSFGHEAGDQVLCEVANRIHGCA
RKTDTVCRYGGDEFIILLTEINKDT-IEAIHRIQCVLKTYFVVNTHILQISASYGIAYGENEK-SPEDLLRNANIALHNAKNSPSEKIIVFENGMHELAM
RNLSLQNDMRRGLEAHEFFIVYQPIFFLSTGELYGFEALLRWSHPQRGIVSPGEFIPAAEESGFIYELGNFALTKACNDFAKLLKTP-NEITLSVNISTK
QLAKDNLIDIIEYAIGKSGLPPGLLILEITESSIMEYPDKSAKIIDAIKSKGIGIAVDDFGTGYSSMSVLQKLKLDKLKIDMSFVNRLTESSEDCEIVRA
IITLSNSLHLQTVAEGIETSEQLQILRSLGCELGQGYLCSKPLDVKDLPLLITQNA----
>tr|C1DD31|C1DD31_LARHH Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Laribacter hongkongensis (stra
-----------------------------------------------------------------------------IEW-----------------DDG
FCVQEWNRAAERMFGFSREEAIGQH-----AFFI-LPSE-VRATLSLMRQEG------TTLVDSNG----K----------SLGVT-----VLDITEKQA
R----RVAA-VYEQSREGILITDAQHRIVMLNSRCCELTGYTQGEVVGTTPEWMF---S-TPGFVELCRHL-----EQG----RQRNGQLFLAWLTLRTV
RLGTS--TYHVCMFGDLSDRQAAERRIQYLAYFDTLTGLPNRALLTDRANMALRGVEDAAPALALLLLDIDHFKHINDTLGHSTGDQLLQSVAKRLQATV
REGDTVSRQGGDEFVVLLPDANA-RAASVAQEILRRLGFVCRIGEHDISVSVSIGIAMAPDDGTDFATLSKCAEIAMYRAKQEGRNTLRFFFPEMQERTL
RHVQLTGALRGAVERGEMQLHYQPQVDLQTGELSGVEALLRWTHPLFGAVSPGEFIPLAEESGLIIPIGDWVLRTAARQLADWLRDGLPPMVMAVNLSVL
QFNLPGLAQQIASILSEAGVPPALFEVELTESMAMTEPEAAIATIDELHSVGVQVSLDDFGTGYSSLAYLKRFRLDRLKIDGSFVRDADSDPEDRAIVDA
IVGMAESLGLATVAEGVETSGQLEVIRALGGDAVQGYWISRPLPAAGLVAWLEGWQ----
>tr|A0A0C6FA60|A0A0C6FA60_9RHIZ Methylobacterium aquaticum DNA, complete genome, strain: MA-22A OS=Methylobacterium aquaticum GN=Maq22A_c09990 PE=4 SV=1
-----------------------------------------------------------------------------ALHDAYSSLVWGAADALCLLDTN
GRVAAWNPGAERLTGYPAAEVLGRR---FAYG----DV---PDGEAAARESG-YEAEG-WWPRRDGSRFRAHTVIAAIHDG-ARLSGYAQ-IREVPARRE
G--------LALSTMSQGLCLFDADRKVRLL-NRFHQM-FPAPGRDLVGAPIEAI---W-GGPEAGLWQGA-----LLA----VVVAT--PD--DRAIAL
VRREVPGGAFVVTFEDVTRQRRAEEEINRLAHHDALTGLPNRAMLWRRLRESAAEGA-LPAGTALLFLDLDGFKAVNDELGHQAGDALLRQLADRLRGAL
PEPGLAARFGGDEFALLLPGGAGL-AVPLAERLLIELGRPYDIEGQPAQVTASIGIALADGTA-TPDAMLRQADCALYAAKGAGKAAWRLFTRRLETERS
DEMRLERDLRQAIAAGQLAVAYQPIIDLAQGSVNAREALLRWTHPERGPVSPRRFIPIAEKSDLIRELGLWVLDQACRAAAAWPDE----ARLCVNVSVY
QLGDGSLPRAVREILGQTGLTPRRLELEITETVLSATAGGIVDDLQLLHDMGVSVSLDDFGVGFSSLARVRAFPIDRIKIDGSFVRDAVERPDCRAIVGI
VAELGRRLGIETVAEGVETPAQLAVVREEGFTEAQGYLFGRAVLPADPAARAAG------
>tr|A9H786|A9H786_GLUDA Gluconacetobacter diazotrophicus PAl 5 complete genome OS=Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / PAl5
--------------------------------------------------------------------------------MGFRLLVDEARDAVYMLDDA
GRVTTWNVGAQRLTGYSAREVLGRV---GGRLYSEAERR-DG-VPA-EA-RE----------RKDGSPFWASVTINPVRDEAGAQVGFAV-VRDDTKRKT
------QMTIALQNMSHGLCLFGADARLILANGRYAEIFGLPEGAAKPGMTYRALLTLV-GTFERQM-ALVRRRRGSVL-YRIMA-DGG-----------
---------WVATYEDITERLRAEARITYLAHHDSLTGLANRAWFTEALDRALTLAASGTQRVAVIGIDLDKFKEINDQHGHAVGDQVLVTLAARIRDVL
EDDELVARLGGDEFAAAKRFD-DAELNAFIGRLEECLSQPIGVDGFELRPNASIGVSLYPRDA-TVEALMGDADLAMYRAKGALREHVCFYEAEMDEAAR
DRRSLVAALWEAVDHHQFHLHFQVQKRVATGEITGFEVLLRWHHPERGWVAPMDFIPLAEECGAILPIGEWVLRQACREAARWSRP----YRIAVNLSAV
QLGEDGLADMVRAILEETGLAPSRLELEITETAIIVDKQQSLRTLQRIKALGVSISIDDFGVGYSSLETLRTFPFDKIKMDRSFMTEIERSPESKAILRA
ILALGRSLTIPVLAEGVETQVQLDILHAEGCIEAQGYLLGRPKPMEIDAEPYRPLD----
>tr|H1SHB9|H1SHB9_9BURK Putative diguanylate cyclase (GGDEF)/phosphodiesterase (EAL) with PAS domain OS=Cupriavidus basilensis OR16 GN=OR16_39169 PE=4 
-----------------------------------------------------------------------------GETELFRTLVLGVTDAIYALDPA
GRVSSWNAGAQRAKGYTRDEILGAH---FSCFYTPEDR---IAGL---------------------TRFWAHVLITPIFDRAGKQLGYAK-TRDMTKQKA
D--------LALENMSQGLCLFDPAGTIILTNRRMEEI-FRGAGAALAPGADFLALCRTEPDGRAEQYAQA-----FDR----WRSVEALPD--GRAIAL
-SHSAMADSWVTTCEDVTEQRRIEAKIQHMARHDGLTGLPNRSYFNDYLDEELLRAQKQGSRVATLGIDLDRFKEINDLHGHAAGDTVLRAVSQRIAGQL
EPGEFIARIGGDEFIAVKRFERQAELSDFSARLVTCLSEPVRLEGFDLTTGASIGIAIYPGDGAHRDQLVSNTDLAMYRAKGSLSESICFYESRMDEAER
ERRALAGELWTAIAANQFVLDYQVQTAIASGEAIGCEVLLRWLHPERGLIPPDNFIPLAEECGAILPIGEWVLRTACREAAQWTFP----RKISVNLSPV
QITHGNLVTLVAQVLEETGLAAGRLELEITESTIIGDKERALDILRRIKALGVTIAIDDFGTGYSSLDTLRAFPFDKIKLDRTFIAEISDSQQAKAIIRA
ILALGQSLAIPVLAEGVETDEQLSLLQAEGCDEAQGFLLGRPQPLEHFRRAHAVIG----
>tr|B1ZLG9|B1ZLG9_METPB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ
-----------------------------------------------------------------------------DADIMYRLLVQGVTDAIYMLSTD
GLVVNWNAGAQRANGYTAEEIIGHS---FAGFYTREDRA-AG-LPE-TARRE----------RKDGSRFWAHVVIDAIHDDEGRFIGFAK-TRDNTEKRA
------AALLAMSNMAQGLCLIDGEGRVVLANERMHEILAVPGCDPLVGAAIRAVLSEA---VADHL-RPDLGLDSVSE-TRRLA-AGG-----------
---------WVSTFVDVTERRQFERQIQHLAQHDLLTDLANRATLHQALTETLASE--TWESCAVLYIDLDRFKPINDTFGHAAGDQLLQEVARRLRRTV
RAQDVIARLGGDEFALILRPADPH-LAGTAQQILEALNQPYAVRRLPIRIGASIGIAAAPLTG-DPDLLLRNADLALYEAKKEGRNRYSFYNPSMGDTAA
ARASLEADLNRALEQREFVLHYQPIVRARTGATIGFEALLRWRRPDGVAISPADFVPAAEEAGLMPEIGAWILAEACREAAAWPAH----LTVAVNVSAT
QLRSALFIDAVERALAASGLPPHRLEVEITETAVLQNRELALSLLQRLRAMGVMIALDDFGTGYSSLSFVHTFPLTRLKIDRSFVQGLGRDPQSTAIVRA
IIGLSRSLRLAVTAEGVETEEQHRLLARERGLDLQGYLLGRPDLPACLDTVGAPRK----
>tr|M5F866|M5F866_9RHIZ Uncharacterized protein OS=Mesorhizobium sp. STM 4661 GN=MESS4_460039 PE=4 SV=1
-----------------------------------------------------------------------------EQNERFSAAVENMSHGLCMFDAD
ERMIICNGNYVSIFCLDTEIV--RP---GIRFFDHSVD--IGVASS-AEELY-PSTYEE----SDGRIIDI--SHRPLAS--GGWV-----YEDITEQRR
-ERELKEQHAALANMSQGLLMYDADGKLIVRNERFLELYKVTPADFLGMSHHDLI-EQL-DREISSTAASL--------THR-HLADGRTL--------S
VVQRPMGGGWVATFDDVTERRRVEERMTHLALHDTLTNLPNRSMFRDRLDQALREA--T--DLAILSLDLDRFKAVNDTWGHPAGDWLLKCVAERLQRSL
RNTDVVARFGGDEFVIIQFNPKGSDAEKLAKRIVDIVGKPFRDKSRDMHVGISLGIALFPNDG-DADTLLKNADMALYRAKSEGRNVYRFFEPGMDAMVR
ARRALETDLEAALPRREFELDFQPIMNIASSDIVGSEALMRWYSPTRGRVPPDDFIPVAEEIGLIVPLGEWALRKACTVAAGWPHG----LRIAVNVSAA
QIKSGTFARSVISALAFSGVPASRLELEITETVLMDESDTVLKTLRQLRELGIRIALDDFGIGYSSLGYLRRFPVDKIKIDRSFIRDIDNR-DTAAIVRT
VIGLGAQLGITVTAEGVETEAQLEFLRKEGCVEAQGYLIGVPSKAADIARLLESRA----
>tr|G6Y9V8|G6Y9V8_9RHIZ Diguanylate cyclase OS=Mesorhizobium amorphae CCNWGS0123 GN=MEA186_13652 PE=4 SV=1
-----------------------------------------------------------------------------EQNERFSAAVENMSHGLCMFDAD
ERMIICNGNYLGIFCLDAGIV--RP---GIRFFDHSVD--IGVASS-AEELY-PSTYEE----SDGRIINI--SHRPLAS--GGWV-----YEDITEQRR
-GQELKEQHAALANMSQGLLMYDTEARLIVRNERFLDLYHVTPADFLGMSHRELL-VQL-DGEISKTMTCL--------THR-SLADGRTL--------L
IARRPLAGGWVATFDDITERRQAEERMTHLAHHDTLTNLPNRSMFRERLDQALSEP--TVAPLAILSLDLDRFKAVNDTFGHPAGDWLLKCVAERLMRCL
RNTDVVARFGGDEFAIIQFNVKGADAERLARRIVEVIGKPYRDKSRDMHIGISLGIALYPDDG-DADTLLKNADMALYRGKSEGRNVYRFFEPGMDAMVR
ERQVLETDLEAALPRREFELDFQPIMNIASGDIVGAEALMRWRSPARGLVAPDDFIPAAEETGLIVQLGDWALRKACTAAAGWPHA----MRIAVNVSAV
QLKSGTFTRSVISALAFSGVPADRLELEITETVLMDESDTVLKTLSQLRDLGIRIALDDFGTGYSSLGYLRRFPVDKIKIDRSFIRDMDNR-DTAAIVRT
VIGLGAQLGITVTAEGVETEAQLDMLREAGCVEAQGYLIGVPSKAADINRLLRSAA----
>tr|X5Q9G3|X5Q9G3_9RHIZ Diguanylate phosphodiesterase OS=Mesorhizobium sp. LSJC280B00 GN=X772_19725 PE=4 SV=1
-----------------------------------------------------------------------------EQNERFSAAVENMSHGLCMFDAD
ERMIICNRNYISIFRLDAEVV--RP---GIRFFDHSVD--IGIASS-AEQLY-PSTYEE----ADGRIVNI--SHRPLAS--GGWV-----YEDITEQRR
-EQELKEQHAALANMSQGLLMYDADGKLIVRNERFLELYHVRPADFLGMSHHDAF-KRL-DSEISQIEACL--------THR-HLADGRTL--------L
VARRPMSGGWVATFDDVTERRRVEERMTHLAHHDTLTNLPNRSMLRERLDQALSET--RDGSLAIFSLDLDHFKAVNDTWGHPSGDWLLKCVAERLQRCL
RNTDVVSRFGGDEFVIIQFNLKSGDAEKLAKRIVEIIGKPFRDKRHDMRVGISLGIALFPNDG-DADTLLKNADMALYRAKSEGRNLYRFFEPAMDAMVR
ARRALEIDLRAALSRREFELDFQPIMNIASGEIVGAEALMRWRSPVRGLVRPDDFIPAAEETGLIVPLGEWALRKACTTAAGWA-A----WRIAVNVSAV
QIKSGTFARSVISALAFSGVPANRLELEITETVLMDESDLVLKTLRQLRDLGVRIALDDFGTGYSSLGYLRRFPVDKIKIDRSFTRDIDSR-DTAAIVRT
IIGLGAQLGITVTAEGVETEAQLEFLQKEGCVEAQGYLIGVPSKASDINRLLKSSA----
>tr|X6HXZ5|X6HXZ5_9RHIZ Diguanylate phosphodiesterase OS=Mesorhizobium sp. L2C054A000 GN=X731_30245 PE=4 SV=1
-----------------------------------------------------------------------------HQNERFSAAVENMSHGLCMFDAD
ERMIICNGNYISIFSLDAKIV--RP---GIAFLDHSVD--IGVASS-AEDLY-ASTYEE----SDGRIVSI--THRPLAS--GGWV-----YEDITEQRR
-EQELKEQHAALANMSQGLLMYDAEGTLIVRNQRFLDLYKVTPDDFLGMSQRALL-EQM-DGEIANTRASL--------TDR-SLADGRTL--------L
VARRPLTGGWVATFEDITERRRAEERMSHLAHYDTLTDLPNRSMFRERLDQAMTGD----TPLAIFSLDLDRFKAVNDTWGHPAGDWLLKCVAERLRHSL
RSTDVVARLGGDEFAILQFNPKGTDAEQLAKRIVAVVSQPFRDKGRDMHVGISLGIALYPGDG-DADTLLKNADMALYSGKSEGRNVYRFFEPGMDALVR
ARLALETDLETALKRREFVLEFQPITNIASGKIVGAEALMRWNSPTRGLVAPDDFIAAAEDSGLIVPLGEWALKQACSVAAGWPPG----MRIAVNVSAV
QIRSADFARSVISALAVSGVPASRLELEITETVLMDESETVLKTLRQLRELGIRIALDDFGTGYSSLGYLRRFPVDKIKIDRSFIHDIDNK-DTAAIVRT
IIGLGAELGITVTAEGVETEAQLDILRKAGCVEAQGFLIGMPSKAADMARLLKTRA----
>tr|E8TLP0|E8TLP0_MESCW Diguanylate cyclase OS=Mesorhizobium ciceri bv. biserrulae (strain HAMBI 2942 / LMG 23838 / WSM1271) GN=Mesci_4807 PE=4 SV=1
-----------------------------------------------------------------------------EQNQRFSAAVENMSHGLCMFDAD
ERMIICNGNYLNIFCLDARVI--RP---GIRFLDHSVD--IGVAST-ADELY-PSTYEE----SDGRIVSI--SHRPLAL--GGWV-----YEDITEQRR
-QEDLKEQHAALANMSQGLLMYDADGKMIVRNRRFLELYKVTPADFLGTTHRDAL-ERL-DSEVAKTEACL--------AYR-HLTDGRTV--------L
VTRRPMDGGWVVTFDDVTERRRTEERMTHLAHHDTLTGLPNRSMFRERLDLALEDT--AATPLAIFSLDLDRFKAVNDTWGHPAGDWLLKTVAERLQRCL
HNNDVVARFGGDEFVIIQFNFKGANAEKLAKRIVETIGKPFRDKSREMHIGISLGIAVFPDDG-DADTLLRNADTALYRAKSEGRNLYRFFEPGMDAMVQ
ARRALEVDLGTALSRQEFDLDFQPIMNIASGEIVGAEALMRWHSPERGMVAPDSFIPVAEETGLIVPLGEWALRKACTAAARWPAG----LRVAVNVSAV
QLKSGSFARSVISALAFSGVPAGRLELEITETVLMDESEVVLRTLRQLRELGIRIALDDFGTGYSSLGYLRRFPVDKIKIDRSFIHDLGNR-DTAAIVRT
VIGLGAELGITVTAEGVETEVQLDILRSNGCTEAQGFLIGAPSQAAEIQRLLRSRA----
>tr|X6CCN8|X6CCN8_9RHIZ Diguanylate phosphodiesterase OS=Mesorhizobium sp. LNHC232B00 GN=X742_29170 PE=4 SV=1
-----------------------------------------------------------------------------EQNERFSAAVENMSHGLCMFDAD
ERMIICNGNYIDIFCLDAKVV--RP---GIRFIDHSVD--IGIASS-ANELY-PSTYEE----ADGRIIRI--SHRPLAL--GGWV-----YEDITEQRR
-EQDLKEQHAALANMSQGLLMYDADGKMIVRNERFLELYKVKAADFLGTTHRDAL-ERL-DSEVAKTEACR--------AYR-HLADGRTI--------L
VTRRPMSGGWVATFDDVTERRRTEERMTHLAHHDMLTGLPNRSMFRERLDLALEDA--AAARLAIFSLDLDRFKAINDSWGHPAGDWLLKCVAERLQRCL
RNTDIVARFGGDEFVVMQFNFKGADAEKLAKRIIEAVAKPFRDKSRDMHVGISLGIAVFPDDG-DADALLKNADTALYRAKSEGRNLYRFFEPKMDAMVQ
TRRALEVDLETALPRQEFDLDFQPIMNIASGEITGAEALMRWHSPVRGTVAPDQFIPVAEDIGLIVPLGEWALRKACAAAAGWPPG----LRIAVNVSAV
QLRSDGFARSVISALAFSGVPAGQLELEITETVLMDESKAVLKALRQLRDLGIRIALDDFGTGYSSLGYLRRFPVDKIKIDRSFIRDIGNR-DTAAIVRT
IIGLGTELGIVVTAEGVETELQLDMLRDNGCTEAQGYLIGVPSKAADIQRLLKSRA----
>tr|A0A090EVI4|A0A090EVI4_MESPL Diguanylate cyclase OS=Mesorhizobium plurifarium GN=MPLDJ20_150502 PE=4 SV=1
-----------------------------------------------------------------------------AQNERFAAAVENMSHGLCMFDAE
ERMIICNRNYIDIFRLDAKVV--KP---GIPFFDHSVD--IGIAGS-ADELY-PSTYEE----SDGRIIVI--SHRPIAV--GGWV-----YEDVTEQRR
-EAELKEQYAALANMSQGLLMYNAEGRLIVRNQRFLDLCNAKAADFLGMTHGQML-AKL-DIEVAKTKAAL--------SYR-ELVDGRTL--------F
VSRRPLAGGWVATFEDVTERRRVEARMTHLAHHDTLTNLPNRSMFREKLDQALGEA--KAKPLAILSLDLDRFKAVNDTFGHPAGDWLLKCVAKRLQHAV
RSKDVVARFGGDEFAIIQSGIKSADAEKLAKRIVEIVGKPYRDKGREMHVGVSLGIALYPGDG-DADTLLTNADMALYRGKSEGRNVYRFFEPGMDALMR
ERRALEVDLEAALSKREFELDFQPILDIGSGKIVGAEALMRWRSPSRGLVSPENFITVAEETGLIVQLGDWALRKACNVAANWPRD----MRMAVNVSAA
QIKSGGFARSVIAALAFSGLPADRLELEITETVMMDESDAVLRTLSQLRSLGVRIALDDFGTGYSSLGYLRRFPVDKIKIDRSFIRDLDRR-DTAAIVRT
VIGLGAELGIIVTAEGVETEAQLDMLRKAGCGEAQGYLIGVPSKASDMSRLLRSQA----
>tr|A0A0D7PCN3|A0A0D7PCN3_9BRAD Diguanylate cyclase OS=Bradyrhizobium sp. LTSP857 GN=UP06_10475 PE=4 SV=1
----------------------------------------------------------------------------------------------------
REVVYCNQRYMDMYRLSPEQV--RP---GTPVGDQHRLA-LGLEID--------RTIQ---EFADGRIIAYAA---HPLPGGGGMATHED-----TEREE
LQRN-----IAINNMSHGLCFFDASHRLIVCNKDFIDMYGLPPERVRPGTPLSEIVDMR--EFMKWRTGVVGSAEPSIM-HRPMP-DLG-----------
---------WVATHEDITEQRRAELKIAHMAHHDALTDLANRTLLNQRLAQA--F-ASNQT-FAVHHIDLDKFKSVNDTLGHHAGDALLRGVSERLRRLV
RPSDTIARMGGDEFVVLQIPVGDSEAGALAQRIIEQMAAPFEIDEQQTIAGASVGIAMAPADG-TPEQLLRNADLALYRAKSDGRGTYRLFEPAMDEEVQ
SRRALELDLRKALAGGEFELHYQPLVKTESGEISGFEALIRWQHPQRGLIAPNDFIPLAEEIGLIVPIGEWVIRQACRTASRWPKH----LHVAVNISAA
QFRYAGLAEVIVGALASAGLEASRLEIEITESVLLQDKEGTLAILHQLRALGVRIAMDDFGTGYSSLTYLQCFPFDKIKIDRSFVRDIATDAGSLNIVRA
IAALANGMGMTATAEGVETREQFERIAAEGCTEMQGYLFSRPLPAAEIERRFLSLG----
>tr|C5B260|C5B260_METEA Putative diguanylate cyclase (GGDEF)/phosphodiesterase (EAL) with PAS/PAC sensor OS=Methylobacterium extorquens (strain ATCC 14
-----------------------------------------------------------------------------EELAR------IAFDLWATD-AE
DRFSYVSPGAERVLGRSPADLI------GLTRSAEGEGS-LAVYR--TARRP--RWFE-----ISGRP--------HFSPEGD-FLGYHG-GSDVTEQHR
TEQN-----AALENMTHGLCMFDAEQRLLVWNRRYLGIFGLPDDAVHVGMGQRAIIEML-DAISEGTRTSLSGDGSVLR-HRPMADGGG-----------
---------WVATFEDITERRRNEARIIHMARHDGLTDLPNRTHLREVGAEWLAALRAAEAPLAVLCLDLDRFKPVNDSFGHAVGDALLRAVADRLRGHV
RSHDVVARLGGDEFAVLSRVE-DAAAAALAERLIETVAAPYTLDGITVEIGMSAGIALA-DVP-DIERLLKEADLALYEAKTEGRGTVRLFEPQMDETLR
ERLGLERELREALTLDRFELHYQPLVDLSDNRITGMEALIRWHHPERGLVSPAVFIPLAEETGLIVPIGEWVLRQACRDAVDWPGE----ISVAVNVSPL
QLRHRGFIQSVLGALAASGLKASRLELEITENVLLDDTEANLETLHTLRKLGVRISMDDFGTGYSSISYLRRFPFDKIKIDRSFVRDCAAQSEAGAIIRA
IVSLGASLGITTLVEGVETEPQLATIRAEGAQEVQGYLFSPPRPVHEIAVLLEAGT----
>tr|C5AVI2|C5AVI2_METEA Putative diguanylate cyclase (GGDEF)/phosphodiesterase (EAL) with PAS sensor putative membrane-associated protein OS=Methylobac
----------------------------------------------------------------------------------------------------
FAATALIASLSAEPTLRLAVVGGAA---ILALVLLILRR-LTRSLQAAESIAAPPSN-------GLRL----I---ADRPRLGDGAD--------PAILT
DDRI-----AALDTLSLGFLLYDRDHRLLVVNRRYHEIYRLPPGAVTPGMSALEVLRSN--ECIAEIGVMMGADAVQIQ-IQPIA-GGG-----------
---------FVAIYEEATERWNAENRIAHMARHDAVTDLPNRVLLRERIEGAITRARRETG-FAVLCLDLDNFKQVNDTLGHAVGDELLRAVAHRLRACL
REVDTVARLGGDEFAIIQASVAAADAATLAQRILNVVSAPYALTHHSVIVGVSIGIALAPGDG-EPERLMQCADVALYRAKDDGRGVFRFFEAQMDARLQ
ARRALELDLRAAFEAEAFDLHYQPIYDLAEERISGFEALLRWTHPTRGRVSPAEFVPLAEEIGLIVPLGEWVLRRACREASGWPDG----LKVAVNVSAA
QFTSIALIGTVQAALAESGLSARRLELEITESVLLVNGSATVAILHGLRDLGARIAMDDFGTGYSSLSYLRSFPFDKMKVDQSFTRDLTVEQGSGFIVRA
VVSLASSLGMTTTAEGVETPEQLAWLREEGCDEVQGYLFSPPVPASELPALLAIWN----
>tr|A0A0B4XD89|A0A0B4XD89_9RHIZ GGDEF/EAL domain-containing protein OS=Rhizobium gallicum bv. gallicum R602 GN=RGR602_PC00718 PE=4 SV=1
----------------------------------------------------------------------------------------------------
LRVVIFNDRIGKLLRAPKGAI--EV---GVSATRAQIPI-LARTQS------TLFYQE---ISIGERIVSLTS---TPVDDGGWLVSCDD-----SALAS
-DQN-----AALANMPHGLCMFDADKNLLLCNAGYCRLYDLPETLTRPGTPLWQILDYR---YFDVVVEAALKGSAENI-HNPME-NGG-----------
---------YVATHEDVTESVRAEEQIKHMAGHDPLTGLPNRALLREKLEKEL-A-LR-KR-CALLCMDLDHFKHANDTLGHAAGDLLLKEVTDRLKKCL
GEGDSIARLGGDEFIVFQEEVQTERAAALAQRLVNAIGETFIVEGQPVQLGVSIGIAITPDDG-TADGVLKNADTALYKAKTDGRGTYCFFEPAMDAGMQ
KRRKLEVDLRQAIAGSQFEIYYQPQVNAGTEEVVGFEALLRWHHPERGLVSPGEFIALAEETGLIVPLGEWVLRQACKDAASWPGH----VRVAVNISPV
QFRSPSLIHTVISALADSGLSAFQLELEITESVLLTDSETALATLHHIKKLGVRIAMDDFGTGYSSLSYLRLFPFDKIKIDQSFIRELGDSKDCAAIVKA
VVDLGSSLGITTTAEGVETTDQLDQVREHGCTEIQGYFFGKPLPFSHVEKLLRKG-----
>tr|A0A084IG14|A0A084IG14_9GAMM Heme-regulated cyclic AMP phosphodiesterase (Fragment) OS=Salinisphaera hydrothermalis C41B8 GN=C41B8_18957 PE=4 SV=1
-----------------------------------------------------------------------------LAERQFRLLFQGVTLAILMLDLE
GIITSNPTGVKTIKGYDADGLLGRH---FSMFYSAADR---ARGLARAREQG-YQEEG-WRYRADGAAFWAHVIIMPLREQ-GRLIGYAK-TRDITGRKE
HYRESRSLSNVIGNIPIRVLVEDGQTGQILVDNKQHAMTAPTIDAS------------T-VERLRGV---A-----KTL----VDSADGAVQLKCRVLRV
-ADEIGGGNLMYLVEDVTEEYRANEKIHFMAHHDALTHLPNRTLFNKRLAQALAASDYDEARVGLLLIDLDNFKNINDVLGHPVGDQLLVQVAARLRGAL
DEPATLARIGGDEFCVVVPRCRDDALEALARRLIETMQAPMGVDEHIVQSGISIGLVISNGDIDNTEELLRCADLALYDAKRGGKGACSIFHAELHRAAR
RRLDLEVDLRRALEADEFVLYYQPIMASDSLTVSGMEALLRWHHPERGVVPPLEFIPVAEETGLIRAIGARVLMQACTEAAGWGCE----ATIAVNLSPV
QFDDHALVDQVREALASSGLPPHRLELEITESILLDASRKNIRLLETLKSLGVKIVLDDFGTGYSSLHYLRSFAFDRIKIDKSFVKEICHDAEAQAIVKA
ITTLGQSLSIQITAEGVEDVEQATRLRTDGCSHLQGFYLVHRTLPGNAALILRK------
>tr|H8DPK9|H8DPK9_9ENTR Heme-regulated cyclic AMP phosphodiesterase OS=Pantoea sp. Sc1 GN=S7A_01195 PE=4 SV=1
-----------------------------------------------------------------------------EQERRFRLLVEGVTDAIYMLDID
GVVVNWNAGAERAKGYRAEEVVGQH---FSLFYSAQERL-NR--TGIALKTG-RFEDEGWRYRKDGSAFWAHVVIDAIHDDDGKLIGFAK-TRDRTERRE
QSTQKTALSNIIANIPSCVIVEDATREILLVNDRTQQLFGLSKSLIVNKRPHECMSPEL--DYFNNLADVALR---SEG--QLLMTASGERILHTRATAI
NGQD-ARRYLMLLVEDVTDQRAADARIHHMAHHDNLTSLPNRILFRQRLSEALRNAGQTPRQTAALCLDLDNFKNVNDALGHQIGDELLRSVAKRLRNVL
RDQDTLARIGGDEFAIVLPSVASDEASVVAQRLIEAIRPPVNIEGHNLSVGLSVGIALSTTIT-TPEQLLRCADMALYEAKRNGRNRFEHFTLEMDDVAR
SRRLIENDLRDAISGGHLRLYYQPITNGDHHTIIGYEALMRWHHPIRGLIMPNDFIPIAEETGLIHMLGAFALYEACREAASWEGN----QSVSVNLSPL
QFKNSSLVPVVEGALQESGLDPARLEVEITESVLLDDSLGNIRTLQNLKALGVQIALDDFGTGYSSLSYLRSFPFDKIKIDKSFINDMGDSREALAIIRA
ITGMSRSLDIQITAEGVESDEQFMKLRDEGCTLFQGFLFGRPQPSELRLKTLGQS-----
>tr|B2VKG3|B2VKG3_ERWT9 Strain ET1/99 complete chromosome OS=Erwinia tasmaniensis (strain DSM 17950 / Et1/99) GN=ETA_30620 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------L-KN--LHRATLTG-RFEDEGWRYRKSGSAFWAHVVIDAIRNDDGELIGFAK-TRDCTKVRE
YSEKMKSLSSIVAHIPSCVIVEDASGEILLVNSQAERLLGGKPHEFIGKTSLNSMSAEM--AYFMQLSDATQR---KGG--RRLKTSGGDRIISCSASIV
RGKD-ARHYILLIADDVTDQRAADERIHHMAHHDNLTSLPNRVLFNQYLTRALREDSAAQRLTAVLGLDLDNFKNVNDALGHQIGDVLLCSVAVRLRGVL
RDRDTLARNGGDEFSIVLPALSHAEAETVARTLIETIRPPFIVEGHSLSIGLSVGITIAQDDT-SPDYLLRCADMALYAAKRNGRNRFEHFTKEMGEMAQ
RRRIVENDLREAITTGQLRLYYQPITNNQHCEIVGYEALMRWHHPEKGVIMPLDFIPIAEETGLIHNLGAYALYEACREAASWPGE----QMVAVNLSPL
QFKSSALIAVVEGALKESGLAPHRLEVEITESVLLDNTMKNIDVLRDLKALGVHIALDDFGTGYSSLSYLRSFPFDKIKIDKSFINDMQDSREALAIIRA
ITGMSRSLDIQITAEGVESIEQFQRLKDEGCTLFQGYYFGRPQPSENRLKTF--------
>tr|U2MKD3|U2MKD3_9ENTR Diguanylate cyclase/phosphodiesterase OS=Pantoea sp. AS-PWVM4 GN=L579_3658 PE=4 SV=1
-----------------------------------------------------------------------------EQEKTFRLLVTGVRDAIYMLDVQ
GRVVNWNAGAQRAKGYRSEEIVGQH---FSVFYGAQERQ-SK--AGIALKTG-RFEDEGWRYRKDGSAFWAHVVIDAIHNEEGRLIGFAK-TRDVTERRE
HSAKASELSTIITHIPSCVIVEDATREILMVNDKAEQLFGINKLLIMHKRPHECMSAEL--DYFNSLADIALR---SEG--QLLLTAGGERILHTRATTI
AGKD-LRQFVMLIVEDVTDQREADARIHHMAHHDNLTSLPNRILFRQKLSEALRADTQGGYITATLCLDLDNFKNVNDALGHQIGDDLLRTVAKRLRNVL
RDHDTLARIGGDEFAIVLPGIRNDEAAVVAQRLIEAIRPPVNLEGHNLSVGLSVGIALSSQAA-TPEHMLRCADMALYEAKRNGRNRYEHFTLEMDDLAR
SRRVIENDLRDAISGRQLKLYYQPITDGDEKGIIGYEALMRWHHPIKGLIMPNDFIPIAEETGLIHLLGAYALYEACREAASWEGE----QSVSVNLSPL
QFKNSSLVSVVEGALRESGLAPHRLEVEITESVLLDDTLGNIRTLQSLKALGVQIALDDFGTGYSSLSYLRSFPFDKIKIDKSFINDMGDSREALAIIRA
ITGMSRSLDIQITAEGVESSEQFARLREEGCTLFQGYLFGRPQPSELRLKTLE-------
>tr|J2V5Y2|J2V5Y2_9ENTR PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Pantoea sp. YR343 GN=PMI39_01008 PE=4 SV=1
-----------------------------------------------------------------------------EQEKNFRLLVEGVRDAIYMLDVQ
GRVVNWNNGAQRAKGYVADEIVGQH---FSVFYSSAERN-AN--AGIALKTG-RFEDEGWRYRKDGSAFWAHVVIEAIRDESGKMIGFAK-TRDITERRE
NSAKMSELSTIISNIPSCVIVEDASREILMVNDKAEQLFGVNKALIMHKRPHECMSAEL--DYFNSLADVALR---SEG--QLLLTAGGERILHTRATTI
SGKD-MRQYVMLIVEDVTDQREADARIRHMAHHDNLTSLPNRVLFRQKLSEALRVDNQNNQVSATLCLDLDNFKNVNDALGHQIGDDLLRVVAKRLRSAL
RDHDTLARIGGDEFAIVLPNVRSDEAAVVAQRLIEGIRPPINVEGHNLSVGLSVGIALTSQTT-TPEHMLRCADMALYEAKRNGRNRFEHFTIEMDDQAR
SRRVIENDLREAISGRQLKLYYQPITD--EKGIIGYEALMRWHHPIKGLIMPNDFIPIAEETGLIHMLGAYALYEACREAQSWNTE----QSVSVNLSPL
QFKNSSLVSVVEGALRESGLAPHRLEVEITESVLLDDTLGNIRTLQSLKTLGVQIALDDFGTGYSSLSYLRSFPFDKIKIDKSFINDMDDSREALAIIRA
ITGMSRSLDIQITAEGVESGEQYAKLREEGCTLFQGYFFGRPQPSELRLKELE-------
>tr|A0A077LR21|A0A077LR21_9PSED PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. StFLB209 GN=PSCI_4801 PE=4 SV=1
-----------------------------------------------------------------------------EQERRFRLLVQGVPDAIYMLDPD
GHVVNWNSGAQRTKGYLAEEIVGQH---FSLFYTAEDRA-KG--LATALRDG-RFEAEGVRQRKDGSTFWTHVLIVPMHDEDGLLIGFSK-TRDITERRE
ASEKMAALSSVIGSIPAGVIVQDATREVLLANEQAQRIFGSAQ-SMVGRRVHECLPANL--DYIREQTNQCLN---GAG--DRLRTAIGPRVLRTKSLRR
IDVD-AHSYVLLITEDVTDEIAAREQIHHMAHHDSLTGLANRTLLHEELQAALHNCAMNQRMVATLCLDLDKFKNVNDAFGHAFGDKLLRAVAERLHGVL
RDEDTLARLGGDEFAIVLPRIDREDALRTAQRIIDCIAPAFLMDGHNFLIGVSIGIAFTRNPH-HAELLLGHADMALYEAKRNGRNRYEVFHEDMAEAAQ
RRRLMEIDLRKALHLGQLHLYYQPIIGMDTSCITGYEALMRWQHPSKGLVMPLEFIPVAEETGLIHEVGARALNLACQEACTWGTE----QSVAVNLSPA
QFKNRELVSIVKLALDDSGLAPHRLELEITESVLLENNEENLETLRALKALGVGIALDDFGTGYSSLGYLRSFPFDRIKIDKSFVHEMEESREAMSIIRA
ITGISSSLLIKTTAEGVETEEQYARLRAEGCSHLQGYLFGRPSPTHERKKKM--------
>tr|A0A0A1B4X3|A0A0A1B4X3_9ENTR Uncharacterized protein OS=Pantoea sp. PSNIH2 GN=PSNIH2_01425 PE=4 SV=1
-----------------------------------------------------------------------------TQEEKFRLLVESVTDAIYMLDTG
GHVVNWNAGAQRAKGYVTSEIIGQH---FSLFYSSQERQ-SR--INIARRTG-RFEDQGWRYRKDGSAFWAHVVIDAIRDESGKLVGFAK-TRDVTERRE
YSERMTSMSTIITSIPSCVLVEDASREILLANRKAEQLFGMEKNSIHGKKPHEFMPPEL--DYFNALADAALR---SEG--RQLVTVGGERILHTRAATV
RGGD-ARTYVMLIVDDVTDQRAADARIHHMAHHDYLTSLPNRILFRQRLSDALRQDALHERQTAALCLDLDNFKNVNDALGHQMGDELLRAIGRRLRAVL
REQDTLARIGGDEFAIVLPGLNNQEASMVAQRLIDVVMPPVNVEGHNLSVGMSIGIAFADAEL-SPEQLLRCADMALYEAKRNGRNRYEYFTLEMDVQAR
TRRSLENDLREAITENQLRLYYQPITNSEQKAIIGYEALMRWHHPVKGLIMPGEFIAIAEETGLIHSLGAWALYEACREAKNWPGD----QTVSVNLSPV
QFKNSALVSTVEGALRESGLEPWRLEMEITESVLLDDTLGNIRTLQSLKALGVLIALDDFGTGYSSLSYLRSFPFDKIKIDKSFISDMSDSREALAIIRA
ITGMSRSLDIQITAEGVESREQFDKLKEEGCTLFQGYFFGRPQPSELRLTML--------
>tr|A0A0D1P2X9|A0A0D1P2X9_PSEPU Pseudomonas putida strain UASWS0946 Contig168, whole genome shotgun sequence OS=Pseudomonas putida GN=QV12_11490 PE=4 SV=1
-----------------------------------------------------------------------------EQERHFRLLVQGVNDAIYMLDPL
GHVINWNAGAERAKGYTHDEIVGQH---FSVFYTPADRA-AG--LDAARQTG-RFEAQGLRQRKDGSHFWTNVVIEAIHDDDGQLLGFAK-TRDITERRQ
YSEKMAALSSVISNIPSSVMVLDVSRQILLANPQAEKLFSSQQCALVGSTPQQSLVPVM--GYLEHLTEHCLN---HDG--DHLDTPLGRRTLRSRTLLS
RNPQVGAGYVLQIADDVTDEIAAHAQIHHMAHHDELTGLPNRTLFHNCLEEALADGQARQHMTAALCLDLDNFKNINDALGHAFGDRLLRALGQRLRSVL
RDQDTLARLGGDEFAVVLPHLAREDAQRTATRLIEAVAPAFLIDGHSFSVGLSVGIAIAPVDH-KADQLLRYADMALYEAKRNGRNRYELFHPELDEAAR
RRRIMETDLRTALHLGQLHMHYQPIIGN-DGQITGYEALMRWQHPVKGQVMPMDFIPIAEETGLIHEVGTRALNLACQEAASWATE----QSVAVNLSPV
QFKNSDLVEVVQLALTDARLDPSRLELEITESVLLENSDGNLRTLQALKDMGVRIALDDFGTGYSSLGYLRSFPFDRIKIDKSFVHDMGESREAMSIIRA
ITGMSSSLLINTTAEGVETEAQFKQLQAEGCSHFQGYLFGHPQPADKRQKGGR-------
>tr|E3DHE1|E3DHE1_ERWSE Sensory box protein OS=Erwinia sp. (strain Ejp617) GN=EJP617_07490 PE=4 SV=1
-----------------------------------------------------------------------------QRDQTFRLLVESVNDAIYMIDLK
GLVVNWNAGACRAKGYTGNEIIGKH---FSYFYGEQDRR-LN--LQQATLTG-RFEDSGWRYRKDGSAFWAHVVIDAIRDDGGELIGFAK-TRDCTEVRE
YSKKMTSLSSIVANIPSCVIVEDASGEILLINHRAQRLLGGSQRDFIGKRALECMTAAM--AYFMQLSSAAQR---KGG--RQLTTPSGDRIISGSASIV
CGKD-ARHYVLLIADDVTDQRAADARIHHMAHHDNLTSLPNRVLFNQHLTTALREDRDAQRLTAVLGLDLDNFKNVNDALGHQVGDALLCSVAVRLRSVL
RDRDTLARNGGDEFSIVLPGLTHEEAEAVARRLIETIRPPFTIDGHNLSIGLSIGITLAQNGM-SPDYLLRCADMALYAAKRNGRNRFEYFTKAMGDTAQ
KRRVIENDLREAITYRQLKLYYQPITNNQHREIIGYEALMRWHHPEKGIIMPLEFIPIAEETGLIHSLGAYALYEACREAASWPGE----QTVAVNLSPL
QFKNGALIAVVEGALKESGLAPHRLEVEITESVLLDNTLANIDMLRELKALGVHIALDDFGTGYSSLSYLRSFPFDKIKIDKSFINDMHDSREALAIIRA
IAGMSRSLDIQITAEGVESNEQFQRLKAEGCTLFQGYFFGRPQPSECRLKKF--------
>tr|Q1IB44|Q1IB44_PSEE4 Pseudomonas entomophila str. L48 chromosome,complete sequence OS=Pseudomonas entomophila (strain L48) GN=PSEEN2310 PE=4 SV=1
-----------------------------------------------------------------------------SPDVMYRLLIQSVVDAIYLLTPE
GIVANWNPGAQRAKGYQAEEIVGQH---YSLFYTEDERA-AG--LEQARSTG-RFEEQGWRLRKDGSAFHAHVLIEAVRDEQGHLIGFAK-TRDISERRR
HSQEMTKLSSVITHIPASVIVQDLSQQILLANQQAEQLFGGQGASLVGKLPGECMAPTA--DYLEQHLARGAR---SAK--TRVDTARGPRTLRSRAMLC
RN-Q-GQGYVLFVAEDATEELAAHAQIHHMAHHDALTGLPNRTLFHERLKQALLRGEDDGKLTAALCLDLDNFKNINDTQGHAFGDKLLRALGKRLRREL
REHDTLARLGGDEFAVVLSGLDSEAASSTAQRLIEAICPPFQIEGHQFSVGVSIGVATAPDDH-QAEQLLGYADMALYEAKRNGRNRFECFHVELDVAAR
QRRLVETDLRTALHLGQLELHYQPVVDQQSNSVTGYEALLRWQHPARGMIMPMDFIPIAEETGLIHEIGARALNLACQEAASWGTE----QTVSVNLSAV
QFKNAGLVHSVALALADSGLPATRLELEITESVLLGNSEENVRTLRALKDLGVSISLDDFGTGYSSLGYLRSFPFDRIKIDKSFVHDMCESREAMSIVRA
ITELSNSLMIKTTAEGVESAEQMQRLMAEGCSHFQGYLYGRPAPASERLRQVGVVE----
>tr|A0A0A0ZCS8|A0A0A0ZCS8_9ENTR Uncharacterized protein OS=Pantoea sp. PSNIH1 GN=PSNIH1_02840 PE=4 SV=1
-----------------------------------------------------------------------------EHEKTFRLLVEGVTDAIYMLDLK
GRVVNWNAGAQRAKGYRADEIVGQH---FSLFYSAQERQ-LH--LGIALKTG-RFEDEGWRYRKDGSAFWAHVVIDAIHDESGRLIGFAK-TRDVTERRE
HSSRMSELSTIISNIPSCVIVEDASREILMVNAKAEQLFGLSRSLLMHKRPHECMSAEL--DYFNSLADIALR---SEG--QLLLTASGERVLHTRATTI
TGKD-MRQYVMLIVEDVTDQREADARIHHMAHHDNLTSLPNRILFRQKLSEALRNDTAQNQISATLCLDLDNFKNVNDALGHQIGDDLLRAVAKRLRSVL
RERDTLARIGGDEFAIVLPDIHNDEAATVAQRLIEAIQPPMNVEGHNLTVGLSVGIALTTQAV-TPEHMLRCADMALYEAKRNGRNRYEHFTPEMDDQAR
SRRIIENDLRDAITGRQLRLYYQPITS--QSGIIGYEALMRWHHPVKGLIMPVDFIPIAEETGLIHMLGAYALYEACREAQSWNTE----QSVSVNLSPL
QFKNSSLVSVVEGALKESGLAPHRLEMEITESVLLDDTLGNIRTLQNLKALGVQIALDDFGTGYSSLSYLRSFPFDKIKIDKSFINDMGDSREALAIIRA
ITGMSRSLDIQITAEGVENSEQFAKLREEGCTLFQGYLFGRPQPSELRLKALE-------
>tr|S2K3V6|S2K3V6_9PSED PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas plecoglossicida NB2011 GN=L321_05197 PE=4 SV=1
-----------------------------------------------------------------------------SPDIMYRLLIQSVVDAIYLLTPE
GIVANWNPGAQRAKGYFAEEIVGKH---YSLFYTEADRA-AG--LEQARQTG-RFEEVGVRLRKDGSVFHAHVVIDAVRDDAGKLVGFAK-TRDISERRQ
QSQEMANLSSVIANIPASVIVQDLTQRILLANQQAERLFGGPGCSMIGRLPGECMAPGA--DYLEQQLGRGAR---SSK--TRVDTLCGPRTLRSRALLS
QNRE-GQAYVLFVAEDATEELAAHAQIHHMAHHDALTGLPNRTLFNERLKQALVRGHEHDRLTAALCLDLDNFKNINDSLGHAFGDKLLRALGKRLRREL
REHDTLARLGGDEFAVVLAGLEHDAASHTAQRLIEAISPPFQIEGHQFSVGVSIGIALSPDDN-QAEQLLGYADMALYEAKRNGRNRYECFNVELDVAAR
QRRLVETDLRTALHLGQLHLHYQPVVDQQTNSVTGYEALLRWEHPTRGMVMPMDFIPIAEETGLIHELGTRALNLACQEAASWDSE----QTVSVNLSPV
QFKNGNLVHIVSLALADSGLPAQRLELEITESVLLGNSEENVRTLRALKDLGVSISLDDFGTGYSSLGYLRSFPFDRIKIDKSFVHDMCESREAMSIIRA
ITELSNSLMIKTTAEGVESEEQMQRLAAEGCSHFQGYLYGRPAPASERLKEVAAV-----
>tr|A0A085GBE3|A0A085GBE3_9ENTR Diguanylate cyclase/phosphodiesterase OS=Ewingella americana ATCC 33852 GN=GEAM_1907 PE=4 SV=1
-----------------------------------------------------------------------------DSDVMYRLLVQSVEDAIYMLTPE
GIVANWNAGAQRAKGYTRDEIVGKH---FSCFYISEDRD-SG--WETARRTG-RYESEGWRQRKDGSRFWAHVIIEAVR-ESGTLLGFAK-TRDVSERRL
YNEKMTALSTVIANIPSSVIVENASREILLVNRQAELLLGKPRDQLIGKRPQDCLNRGI--DYLNKQSDECLR---SEG--QQLATPIGERTLQTTASMI
NGSD-SQTYVLMIADDVTDQHAANARIHHMAHHDNLTSLPNRVLFSQRLNEALQLSKITHRLTATLCLDLDNFKNVNDALGHQIGDELLRGIAKRLRFVL
RERDTLARVGGDEFAIVLPSLPYDKAYQIAQRLIEAVKPPITIEGHSLTVGLSVGIAIAENSD-TPEHLLRCADMALYEAKRNGRNRYEMFREEMDEAAR
KRRDIELDLRYAITSKQLKLYYQPITDSAHDAVIGYEALMRWNHPTNGLIMPMDFIPIAEETGLIHSIGAYALHEACHEAASWVGN----QTIAVNLSPV
QFKNSSLISVIESALSESGLAPNRLEVEITESVLLDNNNANVATLGRLKELGVRIALDDFGTGYSSLSYLRSFPFDKIKIDKSFINDMQDSREALAIIRA
ITGMSRSLDIQTTAEGVETPEQFRRLKEEGCSLFQGYYFGRPQPSESRLTGFSTVA----
>tr|K9E2G3|K9E2G3_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia timonae CCUG 45783 GN=HMPREF9710_00834 PE=4 SV=1
-----------------------------------------------------------------------------NPDLMYRLLVQGVVDAIYMLTPT
GVVSSWNAGAQRAKGYTAGEIVGRH---YACFYGAEDRE-AG--LEIATRTG-RFEDQGWRVRKDGSAFWAHVVIDAIRDDDGALVGFAK-TRDITERHQ
QSRQMASLSSVIANIPASVLVLDVSRTILLANQQAQRLFAQVYVDLKGLPVGDCLSPSV--DYVERQTAHAAP---TRV--VLVETSVGPRSLRSRTVLG
KQPD-GEGYVLIITEDVTDELAAYAQIHHMAQHDGLTNLPNRNLFNARLESALSHSAEDDSGVGILCLDLDNFKNINDAYGHGFGDKILLTLAGRLRKCL
RDQDTLARLGGDEFAVVLPRIKREEAQQAAQRLIEAVAPAFSIEGHSFAVGISVGIALSTSAG-TAEQLLQHADMALYEAKRNGRNRHEVFQPEMEAAAR
VRRQIEIDLRRALHRGELQMHYQPIVEKAGNRISGYEALIRWRHPERGAIAPIDFIPIAEETGLIHELGARALNLACQEAATWTNG----ETIAVNLSPI
QFKSSELVSMVALALADSGLAAERLELEITESVLLDNSDGNIRTLKALKKLGVRISLDDFGTGYSSLSYLRFFPFDKIKIDKSFVQEIGQSREAVAIIRA
ITGLSSSLLIETTAEGVETEEQLRRLVEEGCSHFQGYLFGRPEAAENRMQRLDWPA----
>tr|H2IYR7|H2IYR7_RAHAC PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Rahnella aquatilis (strain ATCC 33071 / DSM 4594 / JC
-----------------------------------------------------------------------------DSDVLYRLLVQRVEDAIYMLTPE
GHIANWNAGAQRAKGYTPEEVVGKH---FSCFYTDEDRQ-NG--WETARATG-RYESEGWRQRKDGSRFWAHIIIEALR-EAGEIIGFAK-TRDVTERRE
TSEQLSSLSTVIANIPSSVIVENASREILLVNRQAERLLGISRDKMLGKRPQDCMGVGL--TFINKQSDECLR---AEG--QQLLTAIGDRTLQTTSSVI
RGHD-PQTYVMMIADDVTDQQAAHARIHHMAHHDNLTSLPNRILFSQRLNEALQRDSYTQSHTATLCLDLDNFKNVNDALGHQIGDELLRAIAKRLRMTL
RDDDTLARIGGDEFAVVLPGLKDSAAHQISKRLIESVRPPVIIDGHSLSVGLSIGIALAGSAE-TPDQLLRCADMALYEAKRNGRNRYEDFRLEMDAAAR
KRRVVEMDLRDAITCNQLRLYYQPITDARHDAVMGYEALMRWHHPENGLIMPVDFIPIAEETGLIHSLGSFALHEACREAASWKGN----QTVAVNLSPV
QFKNSGLLSVVESALEASGLDPSRLEVEITESVLLDNTHGNISTLQKLKSLGVRIALDDFGTGYSSLSYLRSFPFDKIKIDRSFINDMHDSREALAIIRA
ITGMSRSLDIQTTAEGVETDEQFRRLKEEGCTLFQGYFFGRPQPSESRLTGFAPL-----
>tr|S6KDW1|S6KDW1_9PSED Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudomonas sp. CF161 GN=CF161_12116 PE=4 SV=1
---------------------------------------------------------------------------------MYRLLVQSVIDAIYRLTPD
GIVCNWNAGAQRAKGYTSEEIVGEH---FSVFYDPAEQA-AQ--TDIARDTG-RFEAEGWRLRKDGSSFWARVVIDAIHDDDGQLVGFAK-TRDITERRQ
YSEKMASLSSVISNIPSSVMVQDVTRQILLANPQAERLFGNERRHMIGRTASDCMAPAI--GYIEHLTEHCLH---HDG--DRLDTQSGTRTLRTRTLLS
KSTE-ARGYVLQIADDVTDEIAAHAQIHHMAHHDELTGLPNRTLFHACLDEALKEGSRRQNLTAALCLDLDNFKNINDALGHAFGDRLLRALGQRLRGVL
RDQDTLARLGGDEFAIVLPNLASEDAQSTARRLIEAVAPPFLIDGHSFAVGLSLGIAIAPDDH-TPEQLLRYADMALYEAKRNGRNRFELFRAELDEAAR
RRRMMETDLRTALHLGQLQLYYQPIIGQHDQQISGYEALMRWQHPSKGLIMPMDFIPIAEETGLIHEIGARALNLACQEAASWATE----QSVAVNLSPI
QFKNNDLLGIVQLALADSGLAPSRLELEITESVLLDNSEGNLRTLQALKELGVCIALDDFGTGYSSLGYLRSFPFDRIKIDKSFVKDMGQSREALSIIRA
ITGMSSSLLIKTTAEGVETHEQFNQLQAEGCSHFQGYLFGHPRPAAERCKKLP-------
>tr|U5VD71|U5VD71_9PSED PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. VLB120 GN=PVLB_10965 PE=4 SV=1
-----------------------------------------------------------------------------SSDIMYRLLIQSVLDAIYLLTPE
GIVANWNPGAQRAKGYGADEIVGKH---YSLFYKDSERN-AG--LDQARRTG-RFEEIGVRLRKDGTAFHAHVVIDAVYDDDGQLVGFAK-TRDITERRQ
QSQEMTNLSSVISNIPASVIVQDLSQRILLANQQAERLFGGRDANMIGQMPNECLTPAG--EFLGQQFSRGAR---SAK--TRVDTACGPRILRSRSLLC
QNRD-GQAYVLFVAEDATEELAAHAQIHHMAHHDALTGLPNRTLFNERLKQALVRGEDNSKLTAALCLDLDNFKNINDSLGHAFGDKLLRALGKRLRREL
REHDTLARLGGDEFAVVLTNLENEGAYHIAQRLIEAISPPFQIEGHQFSVGVSIGVAIAPQDS-QAEQLLGYADMALYEAKRNGRNRYECFSVEMDVAAR
QRRLVETDLRTALHLGQLHLHYQPVVDQQTSQITGYEALLRWEHPTRGMVMPMDFIPIAEETGLIHELGTRALNLACQEAASWEGE----QTVSVNLSPV
QFKNANLVHTVALALADSGLAPQRLELEITESVLLGNSEENVRTLRALKALGVSISLDDFGTGYSSLGYLRSFPFDRIKIDKSFVHDMCESREAMSIIRA
ITELSNSLMIKTTAEGVESEEQMRRLAAEGCSHFQGYLYGRPAPASERLKQVG-------
>tr|A0A089YGU2|A0A089YGU2_9PSED Histidine kinase OS=Pseudomonas cremoricolorata GN=LK03_17420 PE=4 SV=1
-----------------------------------------------------------------------------SPDAMYRLLIQSVVDAIYLLTPE
GVVANWNPGAQRAKGYSAEEVVGQH---YSMFYTDAERL-AG--LERARVTG-RFEEQGWRQRKDGSHFWTSVVIEAIVDASGTLLGFCK-TRDMTEQRR
YSQEMAGLSSVIANIPASVIVQDASEKILLANQQAERLFGGHGMSMIGLLPAQCPAPAI--DYLGQQLSRGAR---SGR--TRVDTAVGSRTLRSRALLC
NNGK-GHSYVLFVAEDATEQLAAHAQIHHMAHHDALTGLPNRTLFSDRLTQALLRGEEQGKLTAALCLDLDNFKNINDTLGHAFGDKLLRALGKRLRAEL
REHDTLARLGGDEFAVVLTGLDNEAACNTARRLIAAISPAFHIEGHQFSVGVSIGVALSPDDH-HAEPLLCYADMALYEAKRNGRNRFECFHVGLDVAAR
QRRLVETDLRTALHLSQLQMHYQPVVDHHRGCVTGYEALLRWQHPQRGMIMPMDFIPIAEETGLIHDIGIRALNLACQEAASWDSE----QTVAVNLSPV
QFRDANLTHIVALALADSGLPPQRLELEITESVLLGNSEENVQTLRALKALGVSISLDDFGTGYSSLGYLRSFPFDRIKIDKSFVHDMCESREAMSIIRA
ITELSNSLMIKTTAEGVESAEQMRRLAAEGCSHVQGYLYGRPVPASERLIRLSGEV----
>tr|A0A0D0JNV2|A0A0D0JNV2_9PSED Strain MEJ086 contig_124, whole genome shotgun sequence OS=Pseudomonas fulva GN=RU08_26110 PE=4 SV=1
-----------------------------------------------------------------------------EQERRFRLLVQGVTDAIYMLDPQ
GHVENWNAGAERAKGYKAEEIVGQH---FSVFYTPEDRE-AG--LETARSEG-RFEAEGVRLRKDGSPFWTSVVIDAIYDDDRQLIGFAK-TRDITERRQ
NSEEMASLSSVISNIPASVIVQDSSREILLANPRAEKLFGCSTSEMLGRRAEQCLAPAI--DYIAEQTEQCIR---SGA--DCLDTQLGPRMLRTRVLQS
SGVE-QQSYLLMIAEDVTDELAAHAQIHHMAHHDALTGLPNRTLFGERLDEALREGEEKQRLTAVLCLDLDNFKNINDALGHAFGDRLLRSLGQRLKGVL
RERDTLARLGGDEFAVVLNGLESEDAQRTAKRLIAAVAPVFLIDGHSFSVGVSIGVALSPDDH-QADQLMRYADLALYEAKRNGRNRYECFHPELDVAAR
RRRTMEMDLRTALHLGQLQLYYQPIVDNGSNLISGYEALMRWQHPSNGLVMPMDFIPIAEETGLIHDVGARALNLACQEAASWSGK----QTVAVNLSPV
QFKNADLVKVVGLALADSGLEPERLELEITESVLLENSEGNIDTLKALKALGVNIALDDFGTGYSSLGYLRSFSFDRIKIDKSFVQDMGESRESLSIVRA
ITGMSGSLLIKTTAEGVETDAQFEQLKAEGCSHFQGYLFGRPQPASERIEVLE-------
>tr|R9V5N2|R9V5N2_PSEPU Histidine kinase OS=Pseudomonas putida H8234 GN=L483_19265 PE=4 SV=1
-----------------------------------------------------------------------------NPDIMYRLLIQSVVDAIYLLTPE
GIVANWNPGAQRAKGYLADEIVGQH---YSLFYPDAERA-AG--REQARRTG-RFEETGSRLRKDGTAFHAHVVIEAVYDDAGQLVGFAK-TRDISERRR
QSQEMAKLSSVIANIPASVIVQDLSQRILLANQQAERLFGGPGRSMIGQLPGECLSPAA--DYLEQQLARGAR---NTK--TRVETARGPRTLRSRTLLS
QHSE-GQAYVLFVAEDATEELAAHAQIHHMAHHDALTGLPNRTLFHERLRQALVRGSENAKLTAALCLDLDNFKNINDSLGHAFGDKLLRELGKRLRREL
REHDTLARLGGDEFAVVLTGLDGDAACNTAQRLINAISPPFRIEGHQFSVGVSIGIAIAPDDN-QAEQLLGYADMALYEAKRNGRNRYECFDVELDVAAR
QRRLVETDLRTALHLGQLQLHYQPVVDQKTSSVTGYEALLRWEHPTRGMVMPMDFIPIAEETGLIHELGIRALNLACQEAASWDSE----QTVSVNLSPV
QFKNANLVQLVALALADSGLPAQRLELEITESVLLGNSDENVRTLRALKDLGVSISLDDFGTGYSSLGYLRSFPFDRIKIDKSFVHDMCDSREAMSIIRA
ITDLSNSLMIKTTAEGVESQEQMRRLAAEGCSHFQGYLYGRPAPASERLKQVITPG----
>tr|A0A085VDF0|A0A085VDF0_PSESX Histidine kinase OS=Pseudomonas syringae GN=IV01_19070 PE=4 SV=1
------------------------------------------------------------------------------------MLVQGVTDAIYMLDLQ
GHVVNWNVGAQRTKGYKAEEIIGQH---FSVFYTPQDRA-KG--LETARRNG-RFAAEGIRQRKDGSHFWTSVVIDAIYDESGQLIGFAK-TRDISERRR
YSQEMTSLSSVIANIPASVIVQDATKRVLLANQQAQRLFCYRQASMVGRTISACLQPDV--QYIEQQLERVFR---KPG--TLVATVIGDRTLRSRALLC
KNLE-GQSYVLFVAEDVTDELAAQTQIQHMAHHDALTGLPNRTLFNERLALE--LDQHPGKLTGVLCLDLDNFKHINDAFGHAFGDKLLNALGKRLRAEL
REHDTLARLGGDEFAIVLTALEDEAAGSTAQRLISAITRPFSVEEHSLVVGVSIGISIAPDDH-SAQQLLGFADMALYEAKRNGRNRHEYFRPELSDAAR
ARRSIETDLRTALHLGQLQLHYQPIIDSRDRRICGYEALMRWEHPTKGTIMPLDFIPIAEETGLIHEIGSRALNLACREAASWGTR----QTVAVNLSSV
QFNKPGLVDIVALALSDSGLEADRLELEITESVLLENSEENIHTLRALKELGISIVLDDFGTGYSSLGYLRSFSFDRIKIDKSFVRDMGQSREALSIVRA
ITGMSNSLNIKVTAEGVETLEQQAQLEAEGCSHFQGHLFGYPVPADERRKELDPL-----
>tr|A0A0C6FAR6|A0A0C6FAR6_9RHIZ Methylobacterium aquaticum DNA, complete genome, strain: MA-22A OS=Methylobacterium aquaticum GN=Maq22A_c11460 PE=4 SV=1
-----------------------------------------------------------------------------DTDVLYRLLVQGVTDAIYMLDPA
GRVVNWNAGAERAKQYAAAEIVGRH---FSCFYGREDRA-AG--LDRARETG-RFEAQGWRFRRDGTSFWADIVIDAIRDEDGALIGFAK-TRDLTETRE
QRDEHRAISSVIATIPSSVVVQDATGLIRLANRQAELLLCRCTGELVGRPAATVLPPLL--AQLRAA----LA---TPG--APVDTPWGRRTLTMRAMAI
GEE--GEPHALLVAEDITDEHAARVRIHHLAHHDGLTGLPNRELFRQRLGDALSAH--GAAETAVLCLDLDGFKGVNDTMGHPAGDQMLRVIARRLEEAL
RPGDTLARLGGDEFAVVAPVRGAAEATALADRMIAAARRPIVIDGQSFTPGVSIGIALAPSDA-SADELLRCGDLALYEAKRLGRGRHARFHGALEASAR
YRRLIETDLRDAIARRELALHYQPIVRAEDGETVGYEALLRWHHPVRGLIPPLDFVPVAEETGMIDAIGAFVLNEACREASRWGSG----RRVAVNLSPA
QFRNPALAAEVAAALDASGLPADRLELEITESVLLDASSNNLTTLGRLRRLGARIALDDFGTGYSSLSYLCAFRFDKIKIDRAFIRGICDSREALAVVRA
ITGLGRSLGIVVTAEGIETQEQAACLRQEGCTQFQGYLYGKPVPASALAEVSAQPR----
>tr|A0A089Z1E0|A0A089Z1E0_9PSED Strain DSM 16299, complete genome OS=Pseudomonas rhizosphaerae GN=LT40_20100 PE=4 SV=1
-----------------------------------------------------------------------------NSDVMYRLLVQGVVDAIYMLSPQ
GIVSNWNAGAQRAKGYRADEIVGQH---FSCFYTPEDRA-RG--LETARQVG-RFECEGQRVRKDGTLFWTHVVIESIRDDRGHLLGFAK-TRDISEKRA
HSAEMASLSSVIANIPSSVIVQDASRQILLVNLQAERLFGNAREHMIGRQLEQCLAPAL--SYLRRLTDQCVR---TEG--SQQHTPRGLRTLRSKTVTI
SGKA-LGSYVLLIVEDITDENAAQARIRHMAHHDSLTGLPNRALFRQRLEEALREDAGRDRMTATLCLDLDNFKNVNDALGHEFGDRLLRAIARRLRDVL
RANDTLARLGGDEFAVILPELKNEDAQFSAQRLIDTIEPAFLIEGHSLCVGLSVGIALASKDQ-TPEELLRCADMALYEAKRNGRHRYEFFHPRMDAVAQ
KRRTVENDLRQAIVDKQLHLHYQPIIDKCDTRIIGYEALIRWQHPQHGMIMPLDFIAIAEETGLIHELGALALREACHEAQRWPGE----LTVAVNLSPV
QFRNNGLVELVQAALADSGLDAARLELEITESVLLDNNQANIGILQRLKALGVRIALDDFGTGYSSLSYLRAFAFDKIKIDKSFVHDMSDSNEAIAIIRA
ITGMGRSLQMQVTAEGVESDEQFMRLKAEGCSHFQGYLFGRPQPAEHRAR----------
>tr|A0A014ND79|A0A014ND79_9ENTR Diguanylate phosphodiesterase OS=Erwinia mallotivora GN=BG55_00125 PE=4 SV=1
-----------------------------------------------------------------------------HNDVMYRFLVQSVVDAIYMIDTN
GFVINWNAGARRAKGYTADEIVGKH---FSCFYSAQDRQ-AG--VGLARSEG-RFEDHGWRYRKDGSAFWAHVVIEGVHNESGELIGFSK-TRDCTEAHE
YSLSLASLSTIIANIPSCVVVEDLSREILLLNSKAEQLLGICKDQCNGRKLADCTSPEV--RYFAQLTSTVQR---SVG--QLLVTGRGEKIIRASATII
RGND-VRSYILLIADDVTDQRNADARIHHMAHYDNLTGLPNRALFSQRLNDALWRDRAAGKLTAVLCLDLDNFKNVNDALGHQVGDGLLRAVARRLASTV
SDKDTLSRQGGDEFSVVLPGLNYTEAETVAQLMIDVTNPAFTIDGHTLSIGLSIGIAIGSDAI-TSDELLRCADMALYESKRNGRNRFEYFSMAMGEAAS
RRRMIETDLRKAITGNHLKLYYQPITDAHGREVVSYEALMRWHHPVKGMIMPIDFIPVAEETGLIHALGAWALFEACREASGWPEQ----QSVAVNLSPL
QFKSSSLVSVVEQALTESGLPAHRLELEITESVLLDSSLNNIRVLQQLKALGIRIALDDFGTGYSSLSYLRSFPFDKIKIDKSFINDMHESREALAIIRA
ITGMSRSLDIQITAEGVENIQQYEQLKIEGCTLFQGYYFGRPQLAENRLRLFSPVV----
>tr|J4YDJ9|J4YDJ9_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Achromobacter piechaudii HLE GN=QWC_24417 PE=4 SV=1
-----------------------------------------------------------------------------NSDVMYRHLVQGVVDAIYMLHPD
GTVANWNAGAQRAKGYSQEEIVGRH---FSCFYTPGDQD-AG--LARAREQG-RFEAEGWRVRKDGTLFWAHVVIDAIHDDQGALIGFAK-TRDNTERRE
RNTELTSLSAVVSHIPSCVLVQDASRTILLANRQAEAIFGADRAAMIGKTAQQCLPAAV--EFFDRLTNEALR---SDG--EELATARGTRTLRTKTLVF
HSND-PRSYVLLISDDVTDENAAHAQVRYMAHHDTLTGMPNRRLFREQLLKALNSRS-ADRTAAVLCLDLDNFKSVNDTLGHPYGDELLRLLAKRLPKSL
REQDTLARLGGDEFAIVLPSIGQEDVRRMAERLLETVRQPFEIDGHTVPISVSIGIALADTPD-SADHLLRYADMALYEAKRNGRNCLAFFKPEMETAAL
KRHEVEMDLRQAIMGQQLQLHYQPIMDVSHVRVVGREALMRWQHPVKGLIMPNDFIPIAEETGLIHELGAFTLHEACAEAMRWDDH----ETVAVNLSAS
QFTNSALVSLVESALSKSGLPARRLELEITESVLLANSAANLNTLNQLKALGVKVALDDFGTGYSSLGYLRSFEFDKIKIDKSFTQDVESSKEALAIIRA
INGIGRSLDIPTTAEGVETAAQLDRLTEEGCSHFQGYLLGRPVSHETPADGAE-------
>tr|D4X6A2|D4X6A2_9BURK Diguanylate cyclase (GGDEF) domain protein OS=Achromobacter piechaudii ATCC 43553 GN=HMPREF0004_0999 PE=4 SV=1
-----------------------------------------------------------------------------NSDVMYRHLVQGVVDAIYMLHPD
GTVANWNAGAQRAKGYTQEEIVGKN---FACFYSAEDQA-AG--LATAREQG-RFEAEGWRVRKDGTLFWANVVIDPIRDDAGDLIGFAK-TRDVTERRE
RNSELTSLSAVVSHIPSCVLVLDASRNILLANRQAEATFGATRAQMLGKTAQQCLPAPV--EFFDRLTNDALR---SDG--EKLATARGMRTLRTRSLVF
HSND-PRSYALLISDDVTDENAAHAQVRYMAHHDTLTGMPNRRLFREQLLRALNHCA-DDRRTAVLCLDLDNFKSVNDTLGHPCGDELLRLFARRLPKVL
REQDTLARLGGDEFAVVLPNIGQDDVRKMAERIIDAVRQPFEVEGHTVPMSVSIGIALAETPD-TADHLLRYADMALYEAKRNGRNCMAFFKPEMEAAAL
KRHEVEMDLRQAIMGQQLQLYYQPILDVSHVRVVGREALMRWQHPVKGLIMPSDFIPIAEETGLIHELGAFTLHEACHEAMRWDDH----ETVAVNLSAS
QFTNSALVSLVESALSTSGLPARRLELEITESVLLANSATNLNTLNRLKALGVKVALDDFGTGYSSLGYLRSFDFDKIKIDKSFTQDVESSKEALAIIRA
INGIGRSLDIPTTAEGVETAAQLDRLTQEGCSHFQGYLLGRPVSHDAPPDETA-------
>tr|F7T0C0|F7T0C0_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Achromobacter insuavis AXX-A GN=AXXA_11900 PE=4 SV=1
-----------------------------------------------------------------------------HSDVMYRHLVQGVVDAIYMLNPD
GTVANWNAGAERAKGYTRDEIVGRH---FSCFYSPADQA-SG--LSIAREQG-RFEAEGWRIRKDSTPFWAHVVIDAIHDDAGALIGYAK-TRDCTERRE
RNSELTSLSAVVSHIPSCVLVLDASRRILLANRQTENVFGARRDQMQGHTMQQCLPPAV--EFFERLTNDALR---SDG-QEEVVTERGPRTLRSKTLVF
HSSD-PRSYVLLIADDITDENAAQAQVRYMAHHDTLTGIPNRRLFRERLLKALSPEG-RERSAAVLCLDLDNFKSVNDTLGHQYGDELLRQLARRLAKNL
REQDTLARLGGDEFAVVLPGIEKDDLRQMAQRLIDAVREPFQVDGHTVPVSVSIGIARATAQE-GADHLLRYADMALYEAKRNGRNCLAFFKPEMEAAAL
KRHEMEMDLRQAILSQQLQLYYQPIKDASHVRTVGREALMRWQHPAKGLIMPNDFIPIAEETGLIHELGAFTLHEACREAMTWDAH----ETVAVNLSAT
QFTNNALVSLVESALATSGLPARRLELEITESVLLANSEANLTTLNRLKQLGVKVALDDFGTGYSSLGYLRTFEFDKIKIDKSFTQDVESSKEALAIIRA
INGIGRSLDIPTTAEGVETAAQLERLTQEGCSHFQGFLLGRPVSHEPPQPEQAAAP----
>tr|H0F9R3|H0F9R3_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Achromobacter arsenitoxydans SY8 GN=KYC_17593 PE=4 SV=1
-----------------------------------------------------------------------------NSDVMYRHLVQGVVDAIYMLHPD
GTVANWNAGAQRAKGYTADEIVGRH---FSCFYTEADRA-VG--LTTARELG-KFEAEGWRVRKDGTLFWAHVVIDAIHDDAGQLIGFAK-TRDNTERRE
RNDELTSMSAVVSNIPSCVLVLDASRRFLLANRQAEETFGGSPRGLQGKTAQQCLPGLV--EFFDRLTNDALR---SDG--EELATARGPRTLRTKTLAF
HSND-PRSYVLFIADDVTDENAAHAQVRYMAHHDTLTGMPNRRLFRDRLLKALDGR--RDRTTAVLCLDLDNFKSVNDTLGHQYGDELLRLLAKRLPRHL
REQDTLARLGGDEFAVVLPNIAEDDVRKMAERLIDAVRQPFEIDGHTVPISVSIGIALADAQD-SADHLLRYADMALYEAKRRGRNCLAFFKPEMEAAAL
KRHEVEMDLRQAIITQQLQLYYQPIMDVSHVRIVGREALMRWQHPVKGLILPQDFIPIAEETGLIHELGAFTLHEACAEAMRWDDH----ETVAVNLSAS
QFTNGALVSLVESALATSGLPARRLELEITESVLLVNSTGNLATLHRLKELGVKVALDDFGTGYSSLGYLRTFEFDKIKIDKSFTQDVESSREALAIIRA
INGIGRSLDIPTTAEGVETPEQLQRLTAEGCSHFQGFLLGRPVAHGEPAADPVAAG----
>tr|A0A0D6MQI1|A0A0D6MQI1_9PROT PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Tanticharoenia sakaeratensis NBRC 103193 GN=Tasa_052_023 PE=
-----------------------------------------------------------------------------EQTRNFRLLAQGVTDSIYMLDTQ
GRVSNWNAGAERTKGYAAQDIVGRH---FSIFYTADDRQ-AG-LPA-TALAR----------RRDGSCFWALVTIDPIYDEHQRHIGFAN-THDLTSHKN
------AMRLALAHMSQGLCLFDSHECLVVRNSRFTELLALDGAALPPGSTYTDLLWLM-EARARHL-TA--STVPQQE-DRFLP-DGG-----------
---------WVSTIDDVTERREMEREVVHLAHHDVLTDLPNRAAFQTRLTETLTNPG-RTTSCALIYIDLDRFKQINDSFGHPMGDEVLRITAGRIRENV
RPRDTVARLGGDEFVILCQDVYERDAESLAERLARDLSRPLDLTCGTIATSASIGVAMAGPDD-DAEALIHHADLAMYAAKDAGRGRALRYEPGMREALQ
KRRALEHDLRESLENDGFALVYQPVVDTKTGRITSFETLLRWHHPVRGNIPPIDFIPFAEEIGLMPRIDDWVMRTACRQATHWRED----IGVSVNLSPT
RLRLPGLVDAVRITLADCGLAPERLEIEITETSMIADLDNARTVLGELRALGVKIAMDDFGTGYSSLSFLREIPFTRIKIDRSFINDLGESAEATAIVRA
IAGICNSLDVHVTAEGVETDNQANLLRREGCFEHQGYLISRPCPPQDIDEWIRAFD----
>tr|B7KJT7|B7KJT7_CYAP7 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cyanothece sp. (strain PCC 7424) GN=PCC7424_1083 PE=4 SV=1
-----------------------------------------------------------------------------ESEERYRLLVEGIEDGIFMLDGQ
GRIISWNLGAERIQGYQSTEIIGRH---YSIFFTTTDTS-------------F--KGEGWRRRKDGSLFWASIVLSP--VFA-QLKGFAK-TRDISERKQ
A-----------LDQSAIVAVTNSQGIITAVNDQFCQISGYSKEELIGKTHRIINSG---KKFFQQLWATI-----SQG----RSKTGQFYWVATTIVPF
LNQNNQPFQYFAIRFDITQRKLAEKRLRHEVLHDSLTGLPNRTLLIQRLEQVRHRAKKANYCFALLFIDLDRFKNINDNLGHPIGDRVLITIASRLQECV
RSLDTVARLGGDEFIILLDELEEKEIFKIIERIEKQLTTPMVIEGQTLSLTASIGIAFNDTN--SNSDLLRNADLAMYRVKNEGKAGYAIYQSEMYAQAQ
ALWELENHLKLAIERQEFLLYYQPILSLKTLTVIGFEALIRWQHPQRGLISPVHFIPVAEETDLIVAIGEWVLQQSCQQLSAWREKP-NHLTINVNLSNR
QLEKDNFVYKLDNVLQQTGLPATQLKLEITETLLMTNLAAAIATLSQLKQRNINISIDDFGTGYSSLNYLCRLPVSSLKIDRSFVANVHEDSKNLQIIQT
ILSLGEQLMIEVIAEGIETQKHLEQLQELGCQYGQGYLFSKPVNCEAAEQLIC-------
>tr|A0A0C6FK79|A0A0C6FK79_9RHIZ Methylobacterium aquaticum DNA, complete genome, strain: MA-22A OS=Methylobacterium aquaticum GN=Maq22A_c22585 PE=4 SV=1
-----------------------------------------------------------------------------DGVGART-PAEADTPGIVAANAD
GRIVSANRQFAQLYGLAPGEA---V---GLTFEARAWQT-HG---------------------FAGAPFE------VPLPGERWIRVIEH-REDGRTLKR
ER-----SAGIIERMPAGMLVVGGAGDLVEANRAFLHALGREAADLVGRPL--AVLGLP---------GAGEAGE----MRFPRA-DGGTMWARVSAVRL
PLPAD--PSTLLQVEDITARREAERRIAHMAAHDALTDLPNRTLFRTRLDALLGD----GRACAILWLDLDRFKVVNDTLGHAAGDALLCEVGRRMRAVL
RGEDTLARLGGDEFAVLLAGGD-PAASQVASRLVEAMQAPIAVAGRSMHVGVSIGVVLAPGHG-DADTLMARADRALYSAKAAGRSTFRLYDPAMDAAAA
EQRGLELDLRLGLDRGEFVLHYQPIVTAAERRTVCREALVRWHHPTRGLVSPGAFIPLAEETGLIDRLGAWILRQACRDAATWTDG----ARVAVNVSAA
QVRHGPLVAAIQAALRESGLGPDRLEIEITESLLVDGD--AVDLLLALRRLGLRIALDDFGTGYSSLSYLRRFPFDAIKIDRSFIADI-ANPGTAAIVRA
VVGIAAQLGATVTAEGIESEDQCAAARREGCTEMQGYLFGRPVPLDAAA-----------
>tr|A0A0D2UQ65|A0A0D2UQ65_9PROT Skermanella aerolata KACC 11604 strain 5416T-32 contig12, whole genome shotgun sequence OS=Skermanella aerolata KACC 11604 GN=N
-----------------------------------------------------------------------------ASERRFRDLFETMSDSVVILQPQ
DEGTEFVVADMNPCLTDRDQMVGKP---LRDAASAAPLA-------------A--VRRVWRTGRPESRFSIQHDEGGKALDCLPTGEIAC-SEDVTERER
N-----------RHTVEGIFVTDARGIIVSVNPAFTRITGYDEQEAVGQSPRLLRSG---DDFPGILWESL-----KKE----RRKNGEIFLEWATITQV
LDAQGRPSRYVAIFNDITDLHRKDEQIKHQAYHDALTGLPNRLLLSKRIEQAIAVARN-GHGIALLFIDLDHFKTINDCFGHDMGDKLLIEVARRLKSCV
RDSDTVARLGGDEFIIVIGDTSLESVSHVCHRILKSLRQH-FSEPEVEVVTGSIGISQFPEDG-DAETLLKHADIAMYESKRRSRNTISFFTADMTHKMM
RRLELESDLRRSIDHAELEVYYQPKADITAGDIYGMEALLRWRHPIRGMVPPDEFIPLAEEIGMIVPIGEWVLRTACRDAMGL-HA--QRLHLSVNLSMQ
QFRDPDLVARIAGILAETGLAPEWLELELTETIIMTEATQSIEAFNQIKRLGVALSIDDFGTGYSSLSYLTKLPIDTLKIDRSFIQHCGHDGNSATVVSA
IINLAAQLGHSVVAEGVETVAQLAFLRERKCSMIQGYLLGRPVPLSEFTTNLARWG----
>tr|A0A0A6YF97|A0A0A6YF97_9ENTR Diguanylate cyclase OS=Pantoea stewartii GN=OI73_12605 PE=4 SV=1
-----------------------------------------------------------------------------VTNDQLGAAVARTSLAIYLLSST
GEVMSWNLGCREIKGWDSRDIRGQH---ISVFYDEDEQ---ARNIREAREHG-FTGEG-WRLRKNGSAFRASVEIEFLNPSDQEHAAFIK-VRDVTHDYQ
EETELSDTNAVFCHTPCALILCDAKSGDIIRANARN---LPCLQELVLSGNTQTS---L-PDDLAGVFRQA-----TLL----VSSTATEPAFSLRITAE
RLNSGGGEYLLYTILDVTAEFQAAARANHLALHDPLTGLLNRRGLMPELETL--L-S-GDSPFAVMVSDIDRFKSINDVLGHPTGDALLIEVSARLQSVL
RPEDILARTGGDEFVAVLPGISSSEASETASRLTAVLQEPFMLKGRKVTSGCSFGVCLFPGYARDAESMLSAADIALYAAKSAGRNGWVIFTDELARSAA
ERFSLENDLRGALENGELQLFYQPVVCSVSEEIVAYEALLRWHHPVRGSVPPDIFIPLAEKTGLIHDIGAFALARACTDMAGWSGQ----ERIAVNISPR
QFRDPQLSDRVKNVLIHSGLHPNRLELEITESALFDNPDFSYEVIRKFRETGINVVLDDFGTGFSSLSHLSSGLFSRIKIDRSFISDLHQDAGAAAIVSA
VLSLCRQLNVEVTAEGVETLAQAAWLRTYECPLMQGYLFGRP---GPYWIQ--T------
>tr|D4GEW0|D4GEW0_PANAM YciR OS=Pantoea ananatis (strain LMG 20103) GN=yciR PE=4 SV=1
-----------------------------------------------------------------------------VTNDQLGAAVARTSLAIYLLSST
GEVMSWNLGCREIKGWDSRDIRGQH---ISVFYDEDEQ---ARNIREARERG-FTGEG-WRLRKNGSAFRASVEIEFLNPSDEDNAAFIK-VRDVSQGYQ
EETELSDTNAVFSHTPCALILCDVASGDIIRANAMN---LSCLQERVRSGNTRTA---L-PDNLAAVFRQA-----DLL----VSSGDNEPEFSLRISAE
RLNSGGGDYLLYTILDVTAEYQAAVRANHLALHDPLTGLLNRRGLMPELETL--L-D-GDEPFAVMVSDIDRFKSVNDVLGHAAGDTLLIEVSARLLSVL
RPGDILARTGGDEFVAVLPGISSEDASETASRLTMVLKEPFMLKGRKVTSGCSFGVCLFPGYARDAESMLSAADIALYAAKSAGRKGWVIFTDELASSAA
ERFSLENDLRGALENGELQIFYQPVVCSISEEVVSYEALLRWNHPVRGNVSPDVFIPLAEKTGLIHDIGAFALERACNDMAEWSGH----ERVAVNISPR
QFRDPQLANRVKTVLIESGLHPNRLELEITESALFDNPEGSYEMIRRFRDTGIHIVLDDFGTGFSSLNHLSSGLFSRIKIDRSFINDLHLDSGAAAIVSS
VLSLCRQLQVEVTAEGVETPAQAEWLKTNECPLLQGYLFGRP---GPCWIQ--K------
>tr|I4ETK6|I4ETK6_MODMB Str. BC501 chromosome, complete genome OS=Modestobacter marinus (strain BC501) GN=MODMU_1269 PE=4 SV=1
-----------------------------------------------------------------------------GAWRARVTDALGSISAVYVLDPG
DRFTWLNAAAERLLERPATELVGRV------IWAEFSDL-PGSALS------RETQHLEFFYDFLDRWFE-------VRSYPVL----DDLFRDVHERRT
L----AAESAVLNALPSRTAILDGDGTILTTNAAWAAGT-----AAAGR-P-VAS---RGRAAVEGLEQVL-----RQAATPAGDRARETTWWHLQVFPV
DD-GP---RVVVTHTDITDRVTAEQRAAWQARHDHLTALPNRAALDEAIAGALADD--EGGRVTVLYMDVDGFKQVNDSLGHAAGDLLLRELAARLSHRT
RPTDVVGRLGGDEFVVVARDCDA-GGEALARRFRSVFDDPFEVAGTRLPLTVSIGIATSDPAPTRPDELLRDADAAMYAAKAKGRNQHLVFTPALRTTLQ
DRWQITSRLRDAAALDQLVVHWQPVVHLATGDVRGCEALLRWQHPQRGLVGPEDFIPIAEEDGLIVPVTRWLLETTLTQAVTWAEAGL-DLVVAVNVSAV
HLSTGTLVDDVLGAVARTGVPPRRLVLELTETALARDSDRAAEQFAALRSQGVRLAIDDFGSGYSSLSSVASLPADVLKVDRTLVAGPLPARSPDAVLAA
VTALGRALDMRVLAEGIETPEQLARVRAVGCEYGQGHHLAPPLPADRFAALLAEGR----
>tr|D2SGJ9|D2SGJ9_GEOOG Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Geodermatophilus obscurus (strain ATCC 25078 / DSM 43160 / JCM 
------------------------------------------------------------------------------AGHVAPADPLSSVTAVYRIDRR
WRFTYVNAAAQRLLGRRADEMIGRY---AF---ECFPET-LGTVIL------GRVREFEYFYPPLDRWFE-------IRAFADA----GGLLRDVDDQRR
T----LAELAVLEALPPATVLLAGDGRIEMVNRAWTANG-----EALERTGDRPA---RDADIAAGLRSLA-----SGAFDYPHQVGPEPAWFRLQAARV
DA-SD---RVIVTHTDITERVRDQQALAWQASHDDLTGLPNRARLLELIGEALEPG---RGPAALLFLDLDGFKTVNDSLGHHVGDELLRRVGGRLAEQV
RPGDAVGRLGADQFLVLARDCDT-EAASLAFRLQSSFSRPFHAEGISVPLSASIGVAVAQPGADRAHQLLSDADTAAFAAKGAGRDRVHVFSPGLREAAR
WRLEVANRLRDGA-VDEFVVHYQPVVRVDTGEVEGVEALLRWQHPERGLLAPDAFLSVAEETGQLIPITRWLLCETTRQAAEWAAQGL-PLRMSVNISAR
HFSAETLVRDVRVALHDSGLAPENLVLELTETSVAEDPTRAEDQLSILQTSGVSVAIDDFGTGWSSLAQLLALPVGTLKIDRSLLTAAARLASTGPVLAA
IVSLARTLGIRSVAEGVETAEHLQMVREAGCDLAQGYLLAHPMPASEVLHWASRVR----
>tr|H6RJH2|H6RJH2_BLASD Uncharacterized protein OS=Blastococcus saxobsidens (strain DD2) GN=BLASA_0086 PE=4 SV=1
------------------------------------------------------------------------------------------MPAVYRLDQH
GCFAYLNASAERLLGHSADELLGRN---AG---EAFPGL-RGSLAE------GRPREFQFLYEPQGRWYE-------VRIFPDA----AGAFRDVDLRYR
R----DAQVAVLEALPSPTVLVGRDGRILSTNAAWIRAA-----DTLPE-VVLPG---REAALDSGLHALL-----GSEWNYSRATRAGIGWFQLQATRV
DG-EG---RVVITHTDITDQVRAQEQLLWRAQHDDLTGLPNRSRLLELTGEALAAD--HRAGVALLVLDLDGFKTVNDSLGHQIGDELLRLVGGRVSEQI
RPGDAVARLGADQFVVLAHGCDA-EAAALAFRLQTAFGRPFAVGEISVPVSASIGVAVARPEVRDAHHLLSDADAAMFAAKSSGRDRVHLFSPALREAAR
WRLEVATRLRGDA-IDQLVVHYQPVIRLDTGQVEGVEALVRWQHPERGLLPPDTFLAVAEETGQIIPITRWLLRETTLKAAAWAAQGL-NLRMSVNVSAR
HFSTETLVRDVRVALQHSGLPADQLILELTETSVAEDPTRAEDQLNLLRGFGVRVAIDDFGTGWSSLAQLFSLPIGTLKIDRSLLAAAERVAATGAVLTA
IVGLTRTLGIRSVAEGVETVEHLRMVQAAGCDLAQGWLLGHPMPAERVPEWLREVR----
>tr|Q2RU51|Q2RU51_RHORT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 
-----------------------------------------------------------------------------CRH---LAAITDTMSGFYVVDGD
DRIVMANAAAGRILGYTQDDLIGAC---AHALFHARSAD-DPDPVAVRERRARRGGLLGWLLDGDDAEGA-----------PGALL----SFVDITARRE
S----IKLS-AVEQSSASIVITDADGRIEYANPAFTKISGYTAQEAIGRRPSILK---S-ETYR-ALWQTI-----NGG----RRKDGTLYWEMASISPI
RDARGKITNFVAVKDDVTERKAIESELYHRANYDALTGLPNRQLLLDRVSTALDLARRHDRRVAVMFMDIDRFKQINDSMGHAAGDVLLKQAASRLAAVL
RPQDTLGRLGGDEFLVVAPGLRWSEATALASRLLEVARRPFTIDGREVYVSVSIGVSLGPVDGTTAQALMRNADAAMYLAKGGGRDAAHFFTPDIEAAAR
RRMLIENGLRTAVSDGSLYLALQPIIACADHTMIKAEALLRWTHPQLGGVPPSEFIPIAEESGLIRAIGAWVIEEAARLLVSLDPPRDGAFRLGINIASS
QFTG-GLHHHVAGMLARYDLDPRMLEIEITERMLLDPSPAILEQVDALRAMGVSIAIDDFGTGYSALSYLSVFHVDTLKIDRAFVSVMTDEARSQALIGA
IVALGHELGCAVVAEGVETADQARLLGELAVDALQGYFLGRPTTAEAISDRLN-------
>tr|B1Z906|B1Z906_METPB Diguanylate cyclase/phosphodiesterase OS=Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ001) GN=Mpop_0886 PE=4 
----------------------------------------------------------------------------------------------------
AAAVTLAAVSLSMPGLWAATVL-AA---AAALVLLALLR-LARRLRAAEDSA--------------------------------TTA--------LTVAA
DERI-----AALDTLSLGFLLYDRDHRLLVVNRRYHEIYRLPSGAVTPGMSAREVLRRN--EQLAEIGALMGSGAAQIQ-IQPID-GGG-----------
---------FVAVYEEATERWNAEARIAHMARHDAVTDLPNRVLLRERIEGAITQARRETG-FAMLCLDLDNFKQVNDTLGHAVGDELLRAVAHRLRACV
REVDTVARLGGDEFAIIQAAVTTADAATLAQRILDVVSAPYALTHHSVIVGVSIGIALAPGDG-EAERLMQCADVALYRAKGDGRGVFRFFEAEMDARLQ
ARRSLELDLRAAFEAEAFDLHYQPIYDLSAERICGFEALLRWTHPTRGRVSPAEFVPLAEEIGLIVPLGEWVLRRACREAAGWPEG----LKVAVNVSAA
QFTSSALIGTVKAALAESGLPARRLELEITESVLLVNGSATVAILHGLRNLGTRIAMDDFGTGYSSLSYLRSFPFDKMKVDQSFTRDLTVEQGSGFIVRA
VVSLASSLGMTTTAEGVETPEQLAWLREEGCDEVQGYLFSPPVPACALPALLETWN----
>tr|U1H9U9|U1H9U9_9BRAD Diguanylate cyclase (GGDEF) domain-containing protein OS=Bradyrhizobium sp. DFCI-1 GN=C207_00097 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------IG----------------------LA-IGYFVLR-----TPLART---SSAIERP-ETSA---DAYPGMEFLPEYEG-KHEIGALAR
TVQF---KSSAMANMSQGLCMYDADDRLVVCNSRFQDIYGLPAEAIEPGTPIHRVAEPE-EAYATIKA-ALARDERPEQ-AVPTE-NGG-----------
---------WVATFEDISERRAADARIAHMAHHDALTGLPNRVLFRLEAEQALKRARRGEQ-LAVIYLDLDGFKAVNDMLGHAIGDRLLVAVADRLRASM
RDDAFVARLGGDEFAVVL-AVGQDDLAVLAQRIIETLSTPYDIGDHQLMIGASVGIAVAPTDG-DPDQLLKKADMALYRAKADGRGKYFFFEAWMDERMQ
ARRALEVDLRKALAREEFEVFYQPLVNLQTNEVSSFEALLRWRHPVRGMVGPDNFIPLAEEIGLINEIGAWVLKQACSDAMGWPDH----LKLAVNVSSL
QFRSNRLSLDVVAALGHSGLPASRLEIEITETALLQDTEATIAVLYELRQLGLSIAMDDFGTGYSSLGYLRKFPFDKIKIDKSFTLGLPDRADSLAIVRA
MMGLGVNLGMITTAEGVETEEQLAALRAEGCTEVQGYLFSPARPAGEIAALLSRMR----
>tr|V4R3G0|V4R3G0_9RHIZ Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Lutibaculum baratangense AMV1 GN=N177_096
----------------------------------------------------------------------------------------------------
DAAVSAERRYRSISALWPKLA--LE---GVLLATAGFFA-AGSTP-------ATVG-----LLAAAALVIARH---RRPPDLGAPPT-------------
-DRT-----TALDQMSQGLCMFDGDKRLIVSNARYAEIYGIDPGFLRQGVHFLDVLQHR--GYLRERIAAVEERRPKIH-HRPLE-GGG-----------
---------WVATHDDITEIRRIEAQIAHMAHHDGLTDLPNRVLFREELDRALGRVHDGHQ-LAILCLDLDHFKHVNDTLGHPVGDQLLRQVAERLRAQT
RDTDLVARLGGDEFAILQGGVRGRSVKKLADRIISALSEPYDIDGHQVVIGTSIGVAVAPFDS-DADQLIKLADLALYRAKSDGRHTCSFFEPAMDVEVQ
ARRALEVELRRAFEEEALEVHYQPLLDIASGEVTGFEALLRWNHPQRGEVQPADFIPLSEEIGLIGPMGAWVLMEACREAATWPEE----LRLAVNLSPA
QFRGRDLRLDVVVALEASGLAPTRLELEITETVMLQDTGSTLETLHALRRLGVRISMDDFGTGYSSLSFLRRFPFDKIKIDRSFVQDLPDEAGSLAIVKA
VAGLGASLGMATTAEGVETPAQLKKLREEGCLEVQGFLFSPARHPREIPLLLERLR----
>tr|J2W6X0|J2W6X0_9BRAD PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Bradyrhizobium sp. YR681 GN=PMI42_01998 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------MTMHRRQIR-----------QAT-----------ESGQVDL---------TRLGELVSYEE-DSDRRRIEE
LR-----ARSIIENIPIAVAKDAKDSRYVLLNRAGEEYYGMPREEMLGKT-PEQLFPRD-RIVNEQDRRVVDSGTPLE---G--L-NGHDR-LVNSRKLL
VRDGNGAPYLVGVIEDVTERITNEARISHLAHHDALTDLPNRSAFNAALDERLERAQEASTSFAVLSLDLDRFKEVNDVFGHPVGDMLMRAAADRLATEA
-DCAFVARIGGDEFMILMPDEARADVLALAERLVEVIGKELEVDDYLSQVGVSVGIAVYPDDG-DAATLLANADSALYRAKREGRGRVCFFESEMDRELR
DRRLLQHDLRQALEQNQLLVYFQPQARMD-GEIIGFEALLRWNHPTRGFVPPDQFIPLAEENGLIIQIGEWVLREACREAASWPRP----LQVAVNLSPV
QFQAGDLERSIHQILLETGLSPTRLEVEITEGVLIGDFARALNLLRRLKALGIRIAMDDFGTGYSSLSYLQSFPFDKIKIDRSFISNLEATPQSAEIVRA
VLSLAHALNIPVVAEGVETEAQRAFLAREACEEMQGYLVGRPDLIERYLDLVGVAV----
>tr|I0GCU9|I0GCU9_9BRAD Putative diguanylate cyclase OS=Bradyrhizobium sp. S23321 GN=S23_53930 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------MSMHREQLR-----------CAT-----------ATGQVQL---------VKLGELVSYEA-DRDRQRTES
RR-----TRTIVDNIPIAVAKCAKDSRYILLNRAGEDYYGLPREQMLGRT-PEEVFPAD-RIVNEQDRRVVASGMPLE---G--V-KGHDR-VINSRKML
ITDAAGEPYLVGVIEDVTERITTQERISHLAHHDALTDLPNRSAFNAALSERLERAQEASTSFAVLSLDLDRFKEVNDVFGHPVGDMLMRAAAGRLSEEA
-DGGFVARIGGDEFMILMPDDVCEEVLALGERLVEAIGNELEVDDYLPHVGLSVGIAIYPDDG-DAVTLLANADSALYRAKREGRGRVCFFESEMDRELR
DRRLLLHDLRQAVEQNQLLVYFQPQARMD-GEIIGFEALVRWNHPTRGFVPPDQFIPLAEENGLIIRLGEWVLREACREAASWPRP----LQVAVNLSPV
QFQAGDLERSIHQILLETGLAPTRLEVEITEGVLIGDFTRALTLLRRLKALGIRIAMDDFGTGYSSLSYLQSFPFDKIKIDRSFISDLEATPQSAEIVRA
VLSLAHALKIPVVAEGVETEAQRVFLAREACEEMQGYLIGRPEPIERYLDLIGVTV----
>tr|A0A099IQF2|A0A099IQF2_9BRAD Uncharacterized protein OS=Bradyrhizobium diazoefficiens SEMIA 5080 GN=BJA5080_01032 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------MSMHREQLR-----------CAT-----------ATGQVDV---------VKLGELVSYEA-ERDRQRIDA
SR-----TRTIVENIPIAVAKCAKDSRYILLNRAGEDYYGLPREQMLGRT-PEEIFPAD-RVVSEQDRRVVDTGEPLE---G--V-NGHDR-VVNSRKLL
IRDGNGTPYVVGVIEDVTEQLASQARISHLAHHDALTDLPNRSAFNAELDERLELAQEALTSFAVLSLDLDRFKEVNDVFGHPVGDMLMRAAADRLAAEA
-DGAFVARIGGDEFMILMPDNAREDMLTLAERLVEVIGKELEIDDYLSQVGVSVGIAVYPDDG-DAATLLANADSALYRAKREGRARVRFFESETDQELR
DRRLLQHDLRQALEQNQFLVHFQPQARMD-GEVIGFEALLRWNHPTRGFVPPDRFIPLAEENGLIVQIGEWVLREACREAASWPRP----LQVAVNLSPV
QVQAGDLERSIHQILLETGLAPTRLEVEITEGVLIGDFARALNLLRRLKALGIRIAMDDFGTGYSSLSYLQSFPFDKIKIDRSFISNLEATPQSAEIVRA
VLSLAHALNIPVIAEGVETEAQRAFLTREACEEMQGYLVGRPDLIERYLDLVGVTV----
>tr|W1JUW3|W1JUW3_9BRAD Putative diguanylate cyclase OS=Bradyrhizobium sp. CCGE-LA001 GN=BCCGELA001_19895 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------MHREQLR-----------CAT-----------AAGQVDV---------VRLGEFVSYEA-DRDRQRIEA
RR-----TQIIVENVPIAVAKCAKSSRYILLNRAGEDYYGMPREQMLGRT-PEEIFPAE-RVVNEQDRRVVASGMPLE---G--V-KGRGC-VVNSRKML
IKDSDGEPYLVGVIEDVTERIASQARISHLAHHEVLTDLPNRSAFNAALEERLERAQEASTSFAVLSLDLDRFKEVNDVFGHPVGDMLMRAAADRLAAEA
-DGAFVARVGGDEFMILMPDEVSENVLALAERLVETVGNELEVDDYLSHVGLSVGIAFYPDDG-NAATLLANADSALYRAKREGRGRVRSFESEMDQELR
DRRLLLHDLRRALEQNELLVYFQPQARIE-GEVIGFEALLRWNHPTRGFVPPDQFIPLAEENGLIIQIGEWILREACREAASWQRP----LQVAVNLSPV
QFQAGDLEGSIQRILLETGLAPTRLEVEITEGVLIGDFNGALDLLRRLKALGIRIAMDDFGTGYSSLSYLQSFPFDKIKIDRSFISNLEATPQSGEIVRA
VLSLARALNIPVIAEGVETEAQRAFLTREACEEMQGHLVGRPDLIERYLDLVGVTV----
>tr|H5YDP6|H5YDP6_9BRAD Diguanylate cyclase (GGDEF) domain-containing protein OS=Bradyrhizobium sp. WSM471 GN=Bra471DRAFT_01181 PE=4 SV=1
----------------------------------------------------------------------------------------------------
RRVIFCNPRYREMYALSPDQV--HP---GTPIKDEHRLK-LGLNIG--------QTVQ---QFADGRIIAYTI---HPLPDGGGMATHED-----TEREE
LERN-----IAINNMSHGLCFFDAGHRLVVCNTHFIEMYGLPPDRVRPGTPLQEILDLR--EYAKWRTDVATSAEASIV-HRPMP-DLG-----------
---------WVATHEDITEQRKTELRIAHMAHHDALTDLANRALLGQRLEQA--L-EQGGM-FAIHHIDLDKFKAVNDTLGHQAGDILLQDVSRRLKLLA
RDSDTVARMGGDEFVILQSSISDSEADLLARDVVSTLSAPFGLDGHQAIAGASIGIAIAPGDG-TPEQLLHNADLALYRAKSDGRGMHCFFEPAMGEEAQ
SRRALEQDLHNGLAAGEFELHYQPVVKSDGGEISGFEALIRWRHPRRGLVAPNSFIPLAEEIGLIVPIGEWVIRQACATASRWPDH----LHVAVNISAV
QFRQPGLTEVIVGALAASGLDPRRLEIEITESVLLQDRNGTLATLHQLRALGIKVAMDDFGTGYSSLTYLQCFPFDKIKIDRSFVSGVENNAASLSIVRA
VAALARGMGMTTTAEGVETEEQRDRIAAEGCTEMQGYLFSPPLPAEEIERRFLFEK----
>tr|G4RF74|G4RF74_PELHB Uncharacterized protein OS=Pelagibacterium halotolerans (strain JCM 15775 / CGMCC 1.7692 / B2) GN=KKY_903 PE=4 SV=1
----------------------------------------------------------------------------------------------------
LTLELFNSRYAWTFGLAPGAL--AA---GMSLRDRAVIE-AGNYF-------APTQYE---QQLRDRTIRTTY---TGRPGTGWLVTHED-----TDARD
HRQA-----TAVDNMAHGLCMIDADHKLVICNANYAMLYDLPQSLQQPGTLLTDILDYR--AFLQRRVQTITDGKRDIC-HQPMD-DGG-----------
---------WVETHQDITEQRRSEARIHHLARHDALTDLPNRTLFAEEMAMAESRIRRGEM-MAVLCFDLDHFKVINDTLGHGVGDAVLKEVAARINHTK
REHECAARLGGDEFSMLAGPLKSNDAAALAERLIASISQPMEIEGHRVIIGTSIGIAVAPTDG-DGETLMKNADLALYRAKGDGRGNYRFFEKGMDAAMQ
HRRAIESGLKLGLTRDEFRLVFQPLMDLESNRISCMEALLRWEHSEMGFISPVEFIPVAEEIGFIVQLGEWVLRQACLTAANWPAD----IRVAVNLSPV
QFKSRRLMDSVRQALEEAGLPPSRLELEITESVLLNDSDQTLETLHALRAMGIRISMDDFGTGYSSLSYLRAFPFDKIKIDRSFIEDVGSTDANFEIIKA
VIALGRSLGMATTAEGVETEAQLDAVRAHGCNEIQGFLFSRPLPAKDALELITR------
>tr|B1ZEQ0|B1ZEQ0_METPB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ
-----------------------------------------------------------------------------EALAR------IAFDLWVTD-AE
DRFSYISPGAEPMLGRPPTSLI------GTQRSAEAAGS-LATYR--AARRP--RWFE-----ISGRP--------HFSAEGT-FLGYQG-GSDVTEQHR
TEQN-----AALENMTHGLCMFDAEQRLLVWNRRYLEIFGLPEGALHVGMGQRAIIEVL-DAVSEGTRTSLTDEGPVLR-HRPMAEGGG-----------
---------WVATFEDITERRRNEARIIHMARHDGLTDLPNRTRLREIGAERVEALRGADGQLAVLCLDLDRFKPVNDSFGHAVGDALLRAVAGRLRGHV
RGHDVVARLGGDEFAVLSHVE-DAGAMGLAERLIEIVAAPYRLDGITVEIGMSVGIALAGDLP-DIECLLKEADIALYEAKTGGRGTARLFEPQMDATLR
ERLGLERELREALAQSRFELHYQPLVDLSDNRITGMEALVRWRHPERGLVNPAVFIPLAEETGLIVPIGEWVLSQACRDAAAWPDA----ISVAVNVSPL
QLRNRGFVQSVLGALATSGLKASRLELEITESVLLDDTEVNLETLHSLRRLGVRISMDDFGTGYSSISYLRRFPFDKIKIDRSFVPDSAGQSDAGAIIRA
IVSLGASLGITTLVEGVETEPQLATIRAEGAQEVQGYLFSPPRPVHEIAVLLEAGI----
>tr|A0A024KJC5|A0A024KJC5_9RHIZ Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Devosia sp. DDB001 PE=4 SV=1
----------------------------------------------------------------------------------------------------
FRLVMWNRHYLDIYGFSAKAI--RK---GMTLEEELSAR-LGNHP-------RAKERE---TLAGGRTVESAH---VFAPGLGWVVTHED-----TEELE
KRQN-----AAVNNISQGLCMYDPKGRLVICNQPYQRIYNLPEDYLRPGTQLEDILGWL--GYIQWRRDVIAKGEYNIH-HHPMK-DGG-----------
---------WVSTHEDITEQRQTEARIRHLARHDALTDLPNRIQFLEEMASLESGLKRGEK-AAVLCIDLDHFKAVNDTLGHAIGDEVLKQVSARLWGTT
RETDILARLGGDEFSLLLRPVEHADAARVAERIVKVIAAPFQIQGHHILIGASVGIAMAPGDG-LTDTLMKNADLACYKAKSEGRSAYHFFEPGMDADLQ
KRRTIEQGLRVALSRDELRLVFQPLVGLKENRVTCFEALLRWDHAELGTISPAEFIPIAEETGLIVQIGEWVLRQACRAAATWPSG----IRVAVNLSPI
QFKNRKLGETVRAVLAETGLPATRLELEITESLLLADNESTLKTLHELRALGVRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFMRDLDGRSDSLAIIKA
VIGLGHSLGMSTTAEGVETEEQLKAVRDQGCNEVQGFLFSPPIEASAIRKLLATEA----
>tr|B1M2C0|B1M2C0_METRJ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / 
----------------------------------------------------------------------------------------------MMIDAD
GVVQVCNARALALLDLPLALMRSRP---T--FEAQYQIA-QGEFG--------AHTYE--RERPNGTVLEIRT---VPLPDGGAVRTFTD-----TARKR
-EETLQVSELAQDAGSDGLDCDL-TTGEAWSSDRWWGVLGYEPGELASHARTWRALLHP-----------------ALVHRMRRK-DGSWAWMMTRGKVV
ARAADGRARFIGTQIDITARKAAEGQVAHMARHDGLTDLPNRALFYERLEIRLADLHLNGGACAVLCLDLDRFKTVNDSLGHAAGDFLLRAVAHRIRAVL
RADDMVARLGGDEFAVLVADADDARAETLAARLIAAVQAPIPFGKRRLKVGLSVGIAQAPSHG-DSETLFRRADLALHRAKTEGRNTHRVFEPAMDEAEA
ARRDLERDLRQAIEGDELILYYQPQVSTGTGRLLGFEALVRWEHPTRGLVPPNAFIPLAEESGLILPLGEWVLRAACREAARWAHP----LKVAVNLSPR
QFQQADLPERVLAILTETGLAPTRLELEITETLIINDMARALGILRRLKAFGVSIAMDDFGTGYSSLATLQAFPFDKIKIDRSFVGHVEVSPQAAVIVRA
VLGLGRSLGMSVVAEGVETDAQMRFLAAEACDEAQGYLISKPQPIERFAEQIDAPE----
>tr|G4R6X8|G4R6X8_PELHB Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pelagibacterium halotolerans (strain JCM 
----------------------------------------------------------------------------------------------------
FELVMWNQHYLDIYGFPRKSI--RR---GMSLYEALSTA-LGNHP-------RAVNLE---LTASHRTLETAH---IYAPGLGWVVTHED-----TEEIA
RRQY-----AAINNISQGLSMFDNDFRLVTCNAEFVSMYGLPPELARPGASFDDILDHR--AYRAERQKILKGGRFEVV-HQPLS-GGG-----------
---------VVTTHEDITDQLAAEARMRHMATHDALTDLPNRGLFREELETALKGVEKGKQ-PALLAVNIDHFKAVNDSEGHATGDKVLRKIAERLSEAV
GSRGIVARLGGDEFTVLLPNVTVREAADLARSIVKALGEPIMFGRKSIRLSTSIGIAVAPGDG-TTDAVMNNADLALHKAKSEGRGTYHFFEAGMDATLQ
RRRMLETGLHDALANEGLSVLFQPIVSLETDTIVAAEALMRWEHPVLGPISPVEFIPIAEETGIIHAIGGWILDAAAKAAAQWPQH----VRVAVNLSPI
QFKRPDLIATIRSALETAKLDASRLELEITESLLLEDSQSNLDLLLAVRGLGARVAMDDFGTGYSSLSYLRAFPFDKIKIDRSFMADVATKADSRAILGA
MISLGQNLGMTTVAEGVETAEQLAVVRAEGCTQVQGYFFSPPVDGAAMVAMLDAEK----
>tr|J2ANC1|J2ANC1_9RHIZ PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Rhizobium sp. CF142 GN=PMI11_07096 PE=4 SV=1
--------------------------------------------------------------------------------------------MWVYDPDT
LRFLIVNDAALMLYGYSAEDY---Q---GMTVLDPAAER--ERML---HDRT--L--------TYGREVR--------FEGR---VAILA-VQDRTEVNA
-D-----TRSIVDNLPVGVVKDEEDGRYILLNEACGEIMGFHPGDVVGRVD-------R--IFHEQDHEAFVA------ETMERA-DGGKRILRTVKRAL
PASEGKEPYLLGISHDVTEERAVEARLAHLAMHDSLTRLPNRAAFSKHIRKQAITASIEKP-VALLYIDVDHFKTINDSKGHAAGDALLCQVAERLLALG
DEGDLVARLGGDEFAVVLQLVE-DRAERFADLLLKSLARAFDLDGTREHVTCSIGIALAPVDA-EADVLMRHADLALYAAKESGRSTYRFYEPAMRLEAE
RRHHLTGELRDALEHGQFELYYQPIVQLENDGIGGFEALIRWRHPMRGLVAPMEFIPLAEETGLIIPIGDWVLREACRAAASWPDH----LKIAVNLSVS
QFRHASLLSSVVGALDEAGLRPERLEIEITESVFLADVAQSLPLLRALKELGVRIAIDDFGTGYSSLSYLRAFTFDKIKLDRSFVSGIETDPGNLAIVRA
VAGIGSGFNAVTLAEGIETEEQLQKLRAEGFGEVQGYLLGRPMPQHEAEALIYGRQ----
>tr|J0BE15|J0BE15_RHILV PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Rhizobium leguminosarum bv. viciae WSM1455 GN=Rleg5DR
--------------------------------------------------------------------------------------------MWVYDPIS
LRFLIVNEAAAALYGYGADEY---R---RMTVLDPEHER--ERMS---SGRT--L--------TYGREVR--------FEGR---AAILA-VQDRSEVNA
-D-----TRSIVDNLPVGVVKDEADGLYVLFNEACGDIVGMKAEHVVGQTD-------R--AFREQDRRAFEA------ETMLRA-DGMPRILRTVKRAL
PTPEGHAPYLLGISQDVTEERTVEAKLAHLAMHDSLTGLPNRAAFSNHINQRAVEATADSA-IALLYIDVDHFKHINDSKGHAAGDALLCQVSERLLQLA
EEGDLVARLGGDEFAVVLELDE-ERAGRFAQRLLKALSYAFDLDGAREHVTCSIGIALAPDHA-DADVLMRHADLALYAAKESGRSTYRFYETEMRLAAQ
RRHVMTAELWEALEKRQFELHYQPIVQLDNDGIGGFEALIRWRHPKRGLVAPMEFIPLAEETGLIVPIGDWVIREACRAAAGWPAH----LRIAVNLSVS
QFRHASLLSTVVAALDETGLNADRLEIEITESVFLTDADQSLPRLRALKELGLRIAIDDFGTGYSSLSYLRSFPFDKIKLDRSFVSGIETDAGNLAIVRA
VVGIGSGFNATTLAEGIETEEQLQKLRAEGFSEVQGYLLGRPMPQHEAEALIHGRA----
>tr|J2HYY0|J2HYY0_9RHIZ PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Rhizobium sp. CF122 GN=PMI09_05983 PE=4 SV=1
--------------------------------------------------------------------------------------------MWVYDPGS
LRFLIVNNAAVDLYGYSRQDY---A---RMTVLDPEQER--KRML---QRRT--L--------TYGRAVR--------FDGR---DAILA-VQDRTEVNA
-D-----TRSIVDNLPVGVVKDEEDGRYILFNEACGGIVGYDPKDIVGKSD-------R--IFREQDSRALGA------ETMQRA-DGTPRILRTIKRAL
PALDGGAPYVLGISHDVTEERSVEARLAYMAMHDALTGLPNRAFFADHIQREARIATAENP-LALLYLDVDHFKHINDSKGHAAGDALLCQVAARLMQLV
ADGDLVARLGGDEFALLLCSEQ-ESIERFAERLLRSLSAPFDLDGVNEHVTCSIGIALAPEHA-DDDVLMRNADLALYAAKESGRSTYRFYLPEMRLEAE
RRHMLTAELHEALLKGQFELHYQPIVQLDDDGLAGFEALIRWRHPVRGLVPPMEFIPLAEETGLIVQIGEWVLREACRAAAAWPSH----LKIAVNLSVC
QFRHNSLLATVVSALDETGLRPERLEIEITESVFLADVEQSLPLLRALKELGIRIAIDDFGTGYSSFSYLRAFAFDKIKLDRSFVSGIETDPGNLAIVRA
VVGIGSGFNATTLAEGIETEEQLQKLRAEGFSEVQGFLLGRPMLEAEAQALIEGGA----
>tr|J2CWV0|J2CWV0_9RHIZ PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Rhizobium sp. AP16 GN=PMI03_04273 PE=4 SV=1
--------------------------------------------------------------------------------------------MWVYDPET
LKFLIVNDAARDLYGYRHEDY---I---GMTVLDPQKER--ERML---RRRT--L--------TYGREIR--------FDGK---AAILA-VQDRTEVNA
-D-----TRSIVDNLPVGVVKDAEDGRYILFNEACAAAIGRPAKDVVGKND-------Q--AFRQQDERTFET------ETVRGM-DGVTRILRTAKRAL
PAPKGEAPYLLGISQDVTEERGVEAKLAHLAMHDSLTGLPNRAFFSESIVRQVASATPETP-IALLYIDIDHFKHINDSKGHAAGDTLLRQVAQRLLRLA
EKSDLVARLGGDEFALVLRMTD-DRAQRFADLLLLSLAAPFDLDGVREHVTCSIGIAMAPDHA-DADVLMRDADLALYAAKGSGRSTYRFYQTEMRLEAE
RRHQLTVELREALQNGEFELYYQPIIRLDNDGLSGFEALIRWRHPERGLIPPMEFIPVAEETGMIVPIGEWVLREACRTAARWPSH----LKIAVNLSVY
QFRHAGLLATVVSVLDETGLRPERLEIEITESVLLSEVEQSLHLLRALKELGIRIAIDDFGTGYSSLSYLRSFAFDKIKLDRSFVAGIETDPGNLAIVRA
VVGIASGFNAMTLAEGIETEEQLGKLRAEGYSEVQGFLLGRPMPRQDAEALIFGEK----
>tr|L0LV20|L0LV20_RHITR Diguanylate cyclase/phosphodiesterase OS=Rhizobium tropici CIAT 899 GN=RTCIAT899_PC06635 PE=4 SV=1
--------------------------------------------------------------------------------------------MWVYDPQT
LKFLIVNDAARDLYGYGDADF---A---VMTVLDPSVER--ERML---HHRT--L--------TYGREIR--------FDGK---IAILA-VQDRTEVNA
-A-----TQSIVDNLPVGVVKDERDGRYILFNEACGAIAGHAAQDVIGKSD-------R--LFREQDKLAFET------ETIHTV-DGVLRILKTAKRGL
PAPSGQAPYVLGISQDVTEERSVEARLAHLAMHDSLTGLPNRAFFSESIVRQVAAARPEKP-IALLYIDVDHFKHINDSKGHAAGDMLLRQVAERLQQLA
ERSDLVARLGGDEFALVLRMTD-GRAQRFADLLLQSLSAPFDLDGVREHVTCSIGIAMAPEHG-DADVLMRDADLALYAAKASGRSTYRFYQTEMRLEAE
RRHQLTLELREALQNDEFELHYQPIIRLDGDALSGFEALIRWRHPKRGLIAPAEFIPVAEETGMIVPIGDWVLREACRTAMEWPEH----LKVAINLSVY
QFRHASLLATVVSALSETGLCPGRLEIEVTESILLSEVEQSLSLLRALKELGIRIAIDDFGTGYSSLSYLRSFSFDKIKLDRSFVAGMDADPGNLAIVRA
VVGIASGFNAVTLAEGIETEAQLAKLRAEGYHEVQGFLLGRPMSRENALARILNEA----
>tr|U4V737|U4V737_9RHIZ Diguanylate phosphodiesterase OS=Ochrobactrum intermedium 229E GN=Q644_19825 PE=4 SV=1
-----------------------------------------------------------------------------TSEQDFRILFTTHPTMWVYDPET
LRFIVMNDAAYRLYGYTADEIPAMT---VLDIRPQTER---DR--AAIRDRS----------RANGETIDVLTYGRVLFD--GK----EAIVQDRTE---
-NRQASHAQSLVNNLPLGVVKDQDNGRYVLFNQAASVASGQPIEEALGATDLDLFPKRE-AVILEQDRMAM----------KVERKDGTSRTMRIIRCSI
PPVGDEPPYLIGLLEDVTERREIEERMAHIAMHDSLTGLPNRAYFAHHVESLLKKGG-DSEPFALFYLDIDHFKNINDSIGHQAGDQLLQEVARRLKQIT
TPDEFIARLGGDEFAIVYRSGTLGQIAMFADRVLSAFQDSFKLVGNSEFVTCSMGISQAPLHG-NPDALMRNADLALYASKSGGRRTFRFYQHSLRLAAE
KRHVMTGELRQALLDEQFELHYQPIFNLESGRISGFEALIRWRHPERGMVSPAEFIPLAEETGLIGPIGDWVLRAACREAVLWPED----IKVSVNLSPV
QFSQTTLLQSVTDALEAARLSPDRLELEITESVFLSNSKNNIELLFELRRLGVRIAMDDFGTGYSSLSYLRSFPFDKIKIDRSFVSGIEVDTRDLAIIQA
VATLGAGFNIVTTAEGVETAQQLERLKSERFGEVQGFLTGRPMPAGDVHSFIQNRS----
>tr|M3I6B2|M3I6B2_9RHIZ PAS/PAC and GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Ochrobactrum sp. CDB2 GN=WYI_02669 PE=4 SV=1
-----------------------------------------------------------------------------TSDEDFRILFTTHPTMWVYDPET
LAFIVMNEAAHALYGYSADEIPGMT---VLDIRPQTER---ER--AAVRDRS----------KANGETIEVLTYGRVVFD--GK----QVIVQDMTE---
-TRQASHVQGLVNNMPLGVVKDQDEGRYVLYNQAASTISGHNVDHVVGSIDAEIFPSEE-KLLTQQDRLAM----------DIRCADGTPRRMRIIKRPI
PPVGDK-SYLIGLVEDITERRETEQRMTHIAMHDSLTDLPNRAYFSQYIENILKKGD-SAPAFALFYLDIDHFKTINDSRGHQIGDLLLNQVATRLKNIT
TCDQFLARLGGDEFAIIYRSDAI-QIAMFADRLLSAFQDPFDLGDTTEFVSCSLGIAQAPLHG-DTDVLMRNADLALYAAKADGRRTFRFYQHSLRLAVE
KRHAMTTDLRVALAAKQFELHYQPIFNLESGRISGFEALLRWRHPSLGMVSPVEFIPIAEEAGLIGPIGDWVLRQACCQAASWPDE----IKVSVNLSPV
QFNQTTLLDSVTEALEEAALSPDRLELEITESVFLQNSKHNIELLFELRRLGVRIAMDDFGTGYSSLSYLRSFPFDKIKVDRSFVSGIEVDTRDLAIIQA
VATLGAGFRIVTTAEGVETTQQLECLRKQNFGEVQGFLMGRPMPAAEVPEFIQTRC----
>tr|D1CVF3|D1CVF3_9RHIZ Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Brucella sp. 83/13 GN=BAKG_01506 PE=4 SV=1
-----------------------------------------------------------------------------TSEQDFRILFTTHPTMWVYDPET
LRFIVMNDAAYELYGYTADEIPGMT---VLDIRPQSER---DR--SAIRDRS----------RANGEIIDVLTYGRVVFD--GR----EVIVQDRTE---
-NRQASHAQSLVTNLPVGVVKDHDDGRYVLYNQAASTASGQPIDEAIGSIDLDIFPERE-IVFAQHDRMVM----------KVERKDGTSRTMRIIKSSI
PPVGNE-PYLIGLVEDITERREIEKRMAHIAMHDSLTGLPNRAYFAHHVGSLLKQGS-DCDPFALFYLDIDHFKNVNDSISHQAGDQLLQEVVLRLRQIT
TADQFIARLGGDEFAIVYRSGTL-QIAMFADRVLSAFQDPFVLGGNAEFVTCSMGIAQAPLHG-NPDVLMRNADLALYASKSGGRRTFRFYQDSLRLAAE
KRHVMTSDLRQALAAGQFQLHYQPIFNLEGGHISGFEALIRWNHPEHGMIPPLEFISVAEETGLIGPIGDWVLQEACREAARWPED----IKVSVNLSPV
QFGQSTLLQSVTDALGAAHLAPERLELEITETVFLSNSKHNIELLFDLRRLGVRIAMDDFGTGYSSLSYLRAFPFDKIKIDRSFVSGIEVDTRDLAIIQA
VATLGAGFNIVTTAEGVETAQQLERLKNERFGEVQGYFTGRPMRAGDVHAFIRNSG----
>tr|R0CML9|R0CML9_CAUCE Diguanylate cyclase/phosphodiesterase (Fragment) OS=Caulobacter crescentus OR37 GN=OR37_04087 PE=4 SV=1
----------------------------------------------------------------------------------------------------
GRALYANRPISTLMDREPLVV----------------------YA-------LLRGFI---VTEGGRYLGVGT-------VLGLLQAAN------TN-RR
GRAQ-----AIVEAMPSMVVKRADDHSYVLLNRAGEKTLGMSRD---------QVIGKT-ALYVERDREVLLSGE-----HVPRA-DGGMAILRTKK-IA
IRDADGEPYLLGVSEDIAERKRAEAQIARLAHYDPLTELPNRVLFQKSLAEALARRARNGDQLAVHFIDLDRFKTVNDTLGHPLGDALLRVAAERLRNCV
REGDTVARLGGDEFAVVQTGLKDTGATRLAERVVEAMSAPFDLQGHQVVIGASVGVSVAPSDG-DADELLKKADMALYRAKAEGRGAFHFFEHAMDEQLQ
ARRALELDLRRALQAGEFELFYQPLYNLGDERVTGCEALLRWRHPERGMVSPADFIPLAEEIGLIVPLGEWVLRKACAEAAQWPDH----VRLAVNLSPA
QFRDRGLVRTVVSALAGSGLPAQRLELEITESVLLQDSQSNMTMLHDLKALGVRISMDDFGTGYSSLSYLRSFPFDKIKIDQTFVRDILEDSDAMAIIKA
VLDLGSSMGIVTTAEGVETLEQLNALRGQGCAEIQGYFISRPAPAAEIAKMLGVEP----
>tr|A0A068SZQ8|A0A068SZQ8_RHIGA Neorhizobium galegae chromid pHAMBI540a, complete sequence OS=Rhizobium galegae GN=RG540_PA10110 PE=4 SV=1
----------------------------------------------------------------------------------------------------
LRVLVVNNRLSQLLQIPELTM-------GMDAKAEQMP-------Q------KSLQQE---IEVGNGLLSLTS---TPVSEGHWLIQCKD-----SAHAA
-EQT-----TTLANMPHGLCMFDADKNLMLCNAAYSRLYSLPEQLTRPGTPLQQILDHR---YFDVVAEAALKRAVQNI-HSPME-NGG-----------
---------YVAAHEDVTDAVRADEQIKYMAGHDPLTGLPNRTLLREKIDREL-A-VSGKT-SSLLCLDLDRFKEVNDSLGHAVGDLLLKAVADRLTDCL
RDGDSIARLGGDEFVIFQTDVQSDQASSLAQRIIDVVDKAFIIDGKSVRIGVSIGISMAPDDG-MGDSLLRHADTALYKAKAMGRGTFCFFETVMDADRQ
ARRDLETVLQQALESNQFELYYQPQVDTITEQVVGFEALLRWHHPERGLVSPVEFIPLAEETGMIVPIGEWVLRQACKDAASWPAD----IGVAVNLSPL
QFKSQTLAHTVVSALGDAGLPASRLELEITESVLLTDNDTALATLHHIRSLGVRIAMDDFGTGYSSLSYLRLFPFDKIKIDQSFIRELGNSKDCAAIVKA
VVDLGASLGITTTAEGVETSDQLNRVREQGCSEIQGYLFGKPLPISSVHELLKRHS----
>tr|N0B8L9|N0B8L9_9RHIZ Diguanylate cyclase OS=Hyphomicrobium denitrificans 1NES1 GN=HYPDE_38543 PE=4 SV=1
-----------------------------------------------------------------------------TSWGKRGFASALDQFIVSITDPG
GRILHVNDEFIRLSGYSRDELIGRT---HAIL---NSSH-HPKTFAQVRNRG---------KSGRAYWVDA--LIVPLNSRNG-L---KGFQRDITEVVA
L-AESEERATIVESFPGGITAFDKDHNVVLCNRRQRELMHYPDELF-ANGQPTA----EGGDAEEHVRKQL-----IAS----RRPNGTYL--ETRYIPL
--AHG---GFVTTQLDITGRKLDQETIGRLVHHDALTGLPNRSLFLDRMRSSIAG-RG-QELLALHCLNLDNLKLVNESLGDLAGDELLKRTAQRLSRLL
GDSDTAARLGGDDFAVIQAAPKSNDVEAMAKRIISMLSESIGLDGRDITIGTSVGVAVAPTDGTHAVELIRNADAALRRTKSLARGTYGFFEPSMHERLR
QRLRMEMEMREALASNAFELHYQPIVNTKTLKIVGCEALIRWRHPERGLVPASEFIPIAEECGIIGQIGDWVLKTACAEASRWPDD----VWIAVNISAA
QFSGPSLVDKVLAV--SKGLPLSQLVLEITETLLMKNRDIAAATLDRLKKLGVRFAIDDFGTGFSSLSYLQSFPFDKIKIDRSFVSNIANQKRSATLRRS
IIQLGYNLGMTSVAEGVESKQQLDLLRAEGCVEAQGFLFSPAVPSAKIRELFASPL----
>tr|F8JB08|F8JB08_HYPSM Chromosome, complete genome OS=Hyphomicrobium sp. (strain MC1) GN=HYPMC_4315 PE=4 SV=1
-----------------------------------------------------------------------------LSGHVKALASALDPFCVSITDNE
GRIIHVNDAFVRISRYARDALLGQN---HSIL---SSGH-HSRAFSRIQNRA---------KDGTLYWVDA--TIRPLKGRSGRI---IGFQAETAAPVE
T-VARPNNDAVAESFPGGLTVFDRDLHMVLINERQKQLLEYPDDLF-KRGLPTL----EGGETEKQIRSRF-----LTT----RRPNGTCL--EVRSTPL
--TDG---GFIVSHFDITERKRDQETIGRLEHQDALTGLPNRTLFQERVRSALAQAKG-GWALAIHCLDLDRFKSINDTLGHHVGDALLFAVGERLKSEV
RDTDTVARISGDEFAIIQMAPQSEEVESLAKRILSAFSEPFELGDNTLTVGTSIGIAVGPSDGNDAEKLLTNADMALYRTKSVRRGSFGFFEHSMHERLQ
KRHQIIMGLHEAIANSKFELHYQPIVNVKTRRIVGCEALIRWSHPVRGIIPASEFIPIAEECGLIGQIGDWVLKRACAEASLWPDD----IWVAVNISPA
QFREPDLVEKVTNA--AKNIPLSRVILEITETLLMKDRDAASATLETLRKMGVRFSIDDFGTGFSSLSYLQDFPFDKIKIDRSFVSAVANIKRSATLRRS
IIQLGYNLGMTSVAEGVETEQQLERLRAEGCVEAQGFLFSRAVPAAKLRTLFANPL----
>tr|E6VC10|E6VC10_RHOPX Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodopseudomonas palustris (strain DX-1) GN=Rpdx1_3374 PE=4 SV=
-----------------------------------------------------------------------------PSAHSLGMIALAAVLALGVVASY
GGLRSRVSEGKLRRHWMWAT----------APAATSAV---AAAALVA-SDA-------------SAPIWALGLMTGSVIA---TTCFGMMWLNLLAGRR
-RLTLAERDAIVNDTARGFCLFDAGGRLQLWNEAFLDIYGIPPGRDIAGKSLLRI-LALDL---IEL----------------TSVVADLRD--GRHIRI
HLKRLPNGGWIAKHVDITDHKQAEQRFAYLALHDVATGLPNRAAFNERIVASVEQARRFDGSFAVIRLGIDRFKEINDVFGQAVGDAVLAEMARRLADTC
-HWGFLARPGGDEFSIVTPPDAADSIQDVCRQLARLCDSEFEVDGHRIRVGATAGVSVYPRDGEDADALIAHADVALYRAKTEQRGTVCLFEPAMDLQIR
EKRALQRELAVALEQRQFEIHYQPQA-TTSGEIVGFEALLRWRHPIRGMVSPALFVPLAEETGQIGPIDEWVLRSVCTEAASWAKP----LAIAVNFSPL
DFRRLDVPALILQVLLETGLEPSRLEIEITEGVLIDDFSGAIAILRKIKNLGVRVAMDDFGAGYSSLSYLQSFPFDKIKIDQAFTRKLEINPETAAIVEA
ILSLARTLKLPVIAEGVETESQLAFLARAGCDEVQGYLIGRPQPITHYRALTAGEP----
>tr|Q6N7V2|Q6N7V2_RHOPA Complete genome; segment 7/16 OS=Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) GN=RPA2152 PE=4 SV=1
-----------------------------------------------------------------------------PDAHTWGMITLAAVLALGVVAAY
GGLRSRVSEGKGRRHWIIAT----------CFASLSAV---AAVVLAA-SDA-------------LAPTIALVLMIGSVIA---TTGFASLWLSSIAGRR
-QLTLAERDAILNDAARGFCLFDAVGRLQLWNEAFLDIYGIPPGREIAGHSLRRT-LAVDL---IEL----------------ASLVAELRD--GRHIRI
DLRRLPNGGWIAKHSDVTDHKQAEQRFAYLALHDVATGLPNRAAFNDRIVQSVEQARRFDGSFAVIRLGIDRFKEINDVFGQAVGDAVLAEMARRLADTC
-HWGFLARPGGDEFSIVTPPDAADSIQDVCRQLTELCDTEFEVDGHRVRVGATAGVSVYPRDGDDADTLIAHADVALYRAKTEQRGTVCLFEPAMDLQIR
EKRALQRELAVALEQRQFEIHYQPQA-STSGEIVGFEALLRWRHPVRGMVSPALFVPLAEETGQIGPIDEWVLRSVCAEAASWAKP----LAIAVNFSPL
DFRRFDVPALILQILLETGLEASRLEIEITEGVLIDDFAGAIAILRKIKNLGVRVAMDDFGAGYSSLSYLQSFPFDKIKIDQAFTRKLETNPESAAIVEA
ILSLARTLKLPVIAEGVETEKQLAFLAQAGCDEVQGYLIGRPQPIAHYRDLTTGET----
>tr|Q2IV14|Q2IV14_RHOP2 Diguanylate cyclase/phosphodiesterase OS=Rhodopseudomonas palustris (strain HaA2) GN=RPB_3250 PE=4 SV=1
-----------------------------------------------------------------------------WDGQHAGLVGLGLALLLGAMAAA
GALRFRISSGRVRRGWVIAA----------CVAAGCCL---ASALLLAVPSE-------------VVRDVALAIVIVTILG---MTVTVAMWSGAKGTNN
-RSALAERVAIVQKDSHGFCLFSPDGRLEAWNEAFLDIYAIPPGQPLAGATLAEL-VEIDL---SEI----------------SEIVVELSD--GRHIRL
EFRPLPNGGWIAKQADVTDYKMAEQRFAYVTLHDIATGLPNRAAFNQRIGQSLAVARERHASFAVIRLGIDRFKEINDVFGQSVGDAVLAKMAALLTETC
-HWGFLARPGGDEFSIVTQPDQADALQEICSQVLRLCDVEFDIDGHAIRVGSTAGVSIYPRDGDDAETLIAHADVALYRAKNERRGSVCVFEPAMDLQIR
EKRALQRELALALQNDEFELHYQPQA-TTKGEIVGFEALLRWRHPVRGMVSPAAFIPLAEETGLIGAIDEWVLRSACREAASWPKP----LAIAVNLSPL
DFGRLDVPALILQVLLETGLDPKRLEVEITEGVLIDDFSGAIGILRRIKNCGVRVAMDDFGAGYSSLSYLQSFPFDKIKIDQAFTRKLEINPDSAAIVEA
ILSLAHRLNLPVIAEGVETESQLAFLASVGCGEVQGYLIGKPGPIAQYRHLTGGAT----
>tr|P72843|P72843_SYNY3 Regulatory components of sensory transduction system OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=slr1305 PE=4 SV=1
-----------------------------------------------------------------------------INF---AVAFNQSPDIFIYGRNS
GCIMDVNQPFCQFFGLTKQELVGVS---RQQFYFWVDEQ-QR---SFLRDLL------TMLLSGEPMEFNR----------VDCLL-----MRDITERRK
A----KILS-ACEQSPASIVITDVQGNITYVNPKFEEISGYKSAEVLGRNPRILK---S-EDYE-LMWKTL-----SGR----RRKNGELYWERASISPI
SNQQGIVTHYVAVKEDITKEKQQAEALFHQAHYDHLTGLPNRILAKDRLQQAIESALRQKHIFGLMFLDLDNFKKVNDTLGHDAGDQLLVEVSERLQRAL
RQTDTVARLGGDEFLIILDQVSHRKLMAIAQRLLRVMRQPVNLQGLEFFVHGSIGITVFPDDGFHADVLLRNADTAMYAAKLAGRNMFRFFTPHMNQAAQ
QRMAIESELRQGLSRQEFQILYQPIVSLESGQIVGAEALMRWHNRLLGTVPPDQFIPIAEEVGLIVELGEWLLDNVCCQAAHWHSAGEQTFWVSVNVSPR
QLKDSYFVAILQGFLQRYQVRPEWLELEITENLILEENGDLLKNLSDLEEENIALSLDDFGTGYSSLNYLRKFNFNSLKIDRSFVELLPHDNNTVGLVRA
IIAMAHHLELKVIAEGIETPEQWNFLRLQGCDYGQGYLFSPAIAVEEWESL---GQ----
>tr|A0A068N0H0|A0A068N0H0_SYNY4 Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Synechocystis sp. (strain PCC 6714) GN=D0
-----------------------------------------------------------------------------INF---TVAFNQSPDIFIYGCSS
GCIMDVNQQFCRFFGLNKQDLVGIS---RQQFYFWADEQ-QR---SFLRDLL------TMLLSGEPIEFNQ----------VDCLL-----MRDITERRK
A----KILS-ACEQSPASIVITDVEGNITYVNPKFEEISGYSMEEVLGCNPRILK---S-DDYE-FMWHTL-----AGR----RRKNGELYWERASISAI
CDQQGIITHYVAVKEDITKEKQQTAALFHQAHYDHLTGLPNRILAKDRLQQAIESALRHKHLVGLMFLDLDNFKKVNDTLGHDGGDQLLVEVSERLQRAL
RQTDTVARLGGDEFLIILDQVSHRKLMAIAQRLLGVMRQPVNLQGTEFFVHGSIGITVFPDDGLQANVLLRNADTAMYAAKVAGRNMFRFFTPHMNQAAQ
KRMAMESELRQALSSQEFKIFYQPIVNLESGKIVGAEALMRWHNQHLGLVPPDQFIPMAEEVGLIVELGEWLLDHVCRQVAHWHVLDDEFFWLSVNVSPR
QLKDSYFTTILREFLQRYQVRPEWLELEITENLILEENSDLLKNLSDLEQENIALSLDDFGTGYSSLNYLRKFNFNSLKIDRCFVELLPQDNNTGGLVRA
IIAMAHHLGLKVIAEGIETSAQWNFLRAEGCDYGQGYLFSPAIAVEEWESL---WQ----
>tr|K8DGI6|K8DGI6_CROSK Conserved putative membrane protein OS=Cronobacter sakazakii 680 GN=BN126_2019 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------MAGTKNVAAPGTP---SLLIFIDVLSG-A--E-AQMGHEYLGNGHVTMVWRSEDPGHNLIVVILPLLIFLMCFTGLVAGRNALNARLN
DRLALAASEDVAEATTDWIWETDDELRFTWLSERFPVITGYRIADWLGRRVTEFI---Q-EAWF----HQP-----HGGHCRYLSAQGHQRYCNLVAKPI
ATPEGGL-SFRGTATDVTLEVEAQARVQYLSLHDELTGLPNRVRMKEFLEGKLQSRPTREHPLAMISLDLDKFKPVNDLFGHGVGDELLHQVSERLRACL
RDFDLVARQGGDEFILIIPDIEREALEQLCARILAELNRPFSVQDHEILIGASMGIALAPQDAVNATDLLRFSDIALYKAKSRGRNGWVFYNADMAEQIV
QRREMENSLREAIREQQFRLVYQPRYDVNAEKVVAVEALLRWHHPTLGLLMPDQFIPLAEETGLIIAISDWVLNAACRDAQR--DM--PGLSVSVNISAM
EFRTPGLVERVQEVLNTTGLAPERLELEVTENATLSNPEQSLALMNGLKALGVRLLIDDFGTGYSSLSYLRTFPFDGIKLDKSFVAGMPHSDNANSIVEN
IIGLGKAFSLSITAEGVETPEQLAQLKMYQCDETQGYLMCRPLPLERLIAQLRKQ-----
>tr|A0A094MZE2|A0A094MZE2_9GAMM RNase II stability modulator OS=Thiobacillus prosperus GN=Thpro_01696 PE=4 SV=1
------------------------------------------------------------------------------------------------TSTT
-HPSSFNPRGS----------ISPP---PRSAARACSTP-STSIS-------ARRRSRRWSGGAAAH-WVMLLIAALLSMW-LQRRHVLA-GR---HLRI
T-----------DGVDAGIYIKDRQLRYQYVNHRHAEHLGLPAQAIIGRTDDALYDAE--RTQAD-DRRVL-----DDG----QRADGTSRTYLTVKQPL
RDENDEIYALCGISTDFTEQKLNQAEIHRLAFYDPLTGLPNRSLLLDRTRHALDNYET-RLLGALLFIDLDNFKVLNDTLGHGQGDRLLEQVAARIGAEV
RRNDTLARLGGDEFVLLMENLGEPDIEATGRKLLHAFGDPFPLLDEQYNITASIGVALFSEAD-HVDELLKRADMAMYEAKAAGRNQIKFFDPVMQDSLT
ARAALESELHVALKQEQFLLLYQPQTG-RDGQVLGAEALVRWRHPQEGLISPAVFIPVAESTGQILTLGRWVLRTACEQLVAW-QRP-AGLALSVNVSAR
QFHHPDFVSEVLTLLDETGAAPDRLTLELTESLFIDDLDNLVGKMKALKARGVRFSLDDFGTGYSSLSHLKRLPLDQLKIDQSFVRDLLVDPNDAAIVRT
ILALGKSLDLEVMAEGVETAQQREALVAHGCHLQQGYLHGYPGPADAVLEGQAGRR----
>tr|A0A094P369|A0A094P369_9ACTN Uncharacterized protein OS=actinobacterium acAcidi GN=GM46_11780 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------MVLGGAP---LS----------VG--------TALATGEV--------MWIQ--VATQP-VVIDGALAGYIGT-IDCTTLVT
-----RQLSGLLDVSGDAVLVFDRVGELMFANDTARTLIGVTDPGAGAGDVAARTFMQ---AVRDQLPRVLLDAAPDSS----RSPDGIARTLSVVVQVV
RDANGSVHHWATITRDITEERQSQAELARQATHDALTGLPNRVLFERKTTEALERSRTTHSSVAVLFIDLDKLKHVNDTIGHAVGDQLIVTVARRLAAAT
RPSDLVARISGDEFVVLCEGLLDQVALDVAERIRTSITGPLVLQGVEIEAGASIGVAMSTPELLAAVTLLRSADTAMYRAKQRGRGRSELYSEDMRTAAK
ARQTLASELEQALAGDQFAVVFQPIESAHTGRVVAAEALLRWNHPTRGLLAPGAFLDLADESGLIAPIGDWVLNESARTVAEWISSGLRGMTIHVNASRR
QLSDITFVDRALTILRDNNLEGSQLVFETSEATLVDNNPSVLRTVTALKRQGVRIAVDDFGAGYSSLASLRTFPADLLKLDGTLVRDVGRTDGDDPMVRS
LIQLAHSLNLIVCAEWVTTEDHVQRLKVLGCDLLQGNRIGEPISAEAFATKLRRTT----
>tr|M1L5B6|M1L5B6_9BACT Sensory box-containing diguanylate cyclase OS=uncultured bacterium DX-8J-22 PE=4 SV=1
--------------------------------------------------------------------------------RFLRASVEALEDGVTIADPQ
RHLIYVNQAFLKLTGYAMKEVLGRD---CKFLQAP-QTDAQVRQIAIALAQEQSYTGDILNQRNDGTLFWNRLHIDPVLNDQGALTGFIGLQRDITQERE
NRNLIQTLLD-N--AAVGIT-VVRQRQIVQCNQHLAGMIGLSPERVIGQSSDILLQGRNVQDMLETTWGQVLATSGWVSPVWRDGTPFA-VIKFISTEQV
FDACERLASLLGHSLDEHDLRLLQEQEAKIARTDLLTGLPNRRFLEIQMEQAIARAERHNQLLAVCMLDLDGFKPVNDTYGHGAGDEVLVALGKRLSEAL
RKSDFVARLGGDEFVLLVEDLEDDDLANIMKKIEDTITAPIPLSGKSVQIGASMGVALYPFGDTDTDKLLRLADQAMYESKANKAARERFWVLFGEEVQK
---EKCTPGQQLLDAGALEVWYQPVLDSRTRRVVGVEALARLRDTDGTLWTPAEFLPQLQIGNLS-DLTGKVLAQSLADLSLLD-AHGWSLWVSVNLDPR
SVS-EGCITCLQEMIAQSTVDPSRITLEILEGDDFLEQQKALDHLLEIKALGVRLALDDVGSAYSSLLRIKDLPIDEIKLDQSFIRSLEQRPQDLHFVGT
IQDLAAGMGVDLVVEGVETEDILDAIIVTGAQFRKRSAN-PPLRVGANQ-----------
>tr|E6PNV8|E6PNV8_9ZZZZ Uncharacterized protein OS=mine drainage metagenome GN=CARN2_2325 PE=4 SV=1
--------------------------------------------------------------------------------QMLKAAIEASEAGMCVAAPD
YPLVYVNPAFERITGYTAAQALGRN---CRFLQGG-ERDQPLAEVRAALREGRSCRVELRDVRADGGVFWNEMSLAPVRGEAGTITHVVGLMNDVSARHA
LEAENAST-------------------------------------------ELVLSATDLSEMLQQAYREEMREAGVRSPILRGGHRWALLGVVSDRVGV
FTPLERVAVLVGHGLDAFDLQQEHRHISWLAEHDPLTGLLNRRGLRLRLEEALSQVDVQGGFVAVGILDFDDFKQINDNYGHAAGDGLLRTVAARLVEAV
RSSDTVARLGGDEIALVLQGMATDDLEPMLSRIRRAVDLPVALPGEVVHVRASLGFTIYPDDTSEPDELLRHADQALYAIKQQSRASAPFWRVYQPATDR
DHFNHLRLVRDRFAEGGLRVHYQPVVDLTSGRVTEMEALARLDDGNGKLIPPLDFIHQLGRDGLV-ALTGQVLRQAVTDAQQWQRDWGAELSIAVNMDPG
MLASGEALALVNDVVATASFSARRIVLEILEHSDFLSLDTAQQALSELRAVGCRIALDDVGSAYSSLLRMKELPIDIIKLDQGFIRGLAERPQDLRFVQS
LTQLARGLGVDFVAEGAETEDIVEALRALRVPQAQGYGIARPMPASDFG-----------
>tr|F9ZQB1|F9ZQB1_ACICS Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Acidithiobacillus caldus (strain SM-1) GN=Atc_0232 PE=4
--------------------------------------------------------------------------------RCFAAALRAIDEGVVLTDAE
QRVVYANPAFLRLSGYELADILGKN---CRFLQGP-DTDPARQSLHDALAEGRVFHGDILNYRRDGTPFWNALNISPVRDAQGHITHFVSVQRDVTLSRR
TEQELRLSAQ-AFETQEGILITDAQRRIVKVNQAFTRVTGYTLEEVRGLTPAILQSGNQDTDFY-----EIEREGAWQGEIWNRRKNGEVYPEFLSITAV
QDGNGQVSHYIGHFFDISHHKAREATLERLARHDPLTGLLNRRALDEELLRAQRRADAQERLLAVVMLDLDDFKPINDRYGHDQGDALLVLVAQRLRDHL
RRSDAIARLGGDEFVLMLEGRRKDELEPILDKLQRALCQPYRLRGVEVQIGVSMGVSIYPFSAQGNDELLREADQALFAAKQQKGQRLRPWSFWEPPQSA
---RRLYPLRERFRAQGVEAWFQPVWDQQSGRVVGIEALARLLGDDGSVLAPGEFLPQLQETDIF-DLTNQILEQSLTALTALE-DLDPELWVSVNLDPQ
LIG-ITCLKCVQQMLQGQRIAPQRIVFELLESGDFLDRRLAQDHLLDLKAIGVGLALDDIGSGYSSLLRLKELPIDKIKLDQSFVRGLEERPGDLHFVEA
LLELSSSLNVELVAEGVETAAIRDAVAVAGVRYLQGYAIARPMPLDALR-----------
>tr|A0A094QBG3|A0A094QBG3_9GAMM Signaling protein YkoW OS=Thiobacillus prosperus GN=Thpro_01862 PE=4 SV=1
--------------------------------------------------------------------------------HLESRAIEAAQQGISIAQPE
QPLIYVNPAFTRITGYTAAEVLGRN---CRMLQDD-TADAARALLRDAIEARRPATVVLQNRHKDGHHFWNEISLSPVVSDEGELTHYIGLQTDVSDRMR
EEIYRRQMTSVVENMQEGVVFTDAGLRMLNVNPAFVRITGHDRDEVLGQTL------RHDQDGYGEMREALETVGCWQGELWNRRRNGEAYPGQLSISAV
RNDQGTVLHYVGVFTDITAL---EMALQQAATRDFLTGLPNRFALDQRLEACLPRALRQQTLLAIGLLDLDGFKAVNDTYGHDVGDLLLRQLADRLRRVL
RSSDFLARLGGDEFVLLMEDIRRADVEQLLERIGSVFDAPFHVG-HEVDMKASLGLTLYPLDDSKPRDLMRHADHALYAAKGRDRVRGLFYTLYAYNPAV
HDAGQMPQPLKRLAPQDLTVYYQPVIELPARSMSGVEALARLHHRQGT-RGPDDFLAQLAPVDVR-RTSFVVLDQALAQLRRWE-GAGLSLGVSVNFEPL
DLLAPSTALAIQSRLEAHDIDPARLTIEIIDSGRLFADPAMRERLQTLKALGIGLALDDLGSAYASLERLRSLPFDSLKLDRGFGIGLDRRPADLRFLLG
LVDLAQSLGVSLVVEGVDSPETLAAVQTLGVHRVQGYFLSPPLSGEELA-----------
>tr|B6AQW0|B6AQW0_9BACT Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Leptospirillum sp. Group II '5-way CG' GN=CGL2_11068007
--------------------------------------------------------------------------------ENLTLLLDSSLSTNK--QPD
FPIIFANDMFFRLTGYSRAET-GKN---CRFLQGA-DREQKRTEIREALKAGKAIRTLIRNYRGTPFMNELSL--FPITDPDGTVTHYLGIQNDVTDTLI
LEKNREIASKVFDMASDGILITDSENRIVLVNRAFTEITGYSQEEVKGKNPRILSSGRQDAFFYQTMWHELLANGYWQGELWNRRKSGELYPEWLSISTR
KDKNGRIENHIGIFHDLTGVKESEERIAFLAYHDPLTGLPNRVLLRDRLEYALRQTTRTGKDLGILLLDLDGFKNVNDLSGHHVGDLLLMEVSRRMAGAV
RTSDSVGRMGGDEFLILFPDLTGEELSSIMDRLLEQVRHPFEIEGHSVTLTASGGVTLYPRDNAGIDDLIRHADIAMYSAKNRGKNRIHFYELSMEQSLR
SRETLKQELTRALQNGHLHLLYQPQIDIRTGVLIGAEALLRWFHPD-GIRLPADFLGTIENDDLSIELGRWVLGEALRQHLQWKQEGQF-FRIGVNISPR
HFGSGVLEQNLVDVRGIEDL--SGLELEITENTLVSDLGEVQKTVRACREMGVHIAFDDFGTGYTSLTMVRTLCPDTLKVDQSFLRSITENPGNRSILES
ILKIGQGFQAAVIMEGVENARELGLVREIGYHCIQGYLVSPPLLPSQFS-----------
>tr|E6QHF3|E6QHF3_9ZZZZ Uncharacterized protein OS=mine drainage metagenome GN=CARN6_2776 PE=4 SV=1
--------------------------------------------------------------------------------AAFRAYFERAMVGMALLAPS
LPEFYNAA----ISGVEIGPGLGKR---VRDYKGLAGLASCSEPIFGS--SGK-VLGTFAIYRGAPDEADLAM--------IESTANLIGI---AIERKR
IEEELGLASMVYRNTSEAMMVTDEENRIIAINPAFTQITGYGMDEVLGRNPGMLSSGRHDADFYKILWREIESTGIWQGEIWNRRKNGEIYPEWLTINTI
LNDDGSTHRYVALFSDITDKVRTDELIWRQANFDLLTGLPNRRMFYDRLEREVKKAHRGNLMLALLFIDLDRFKEVNDTLGHQTGDILLVEAARRIVSCV
RESDTVARLGGDEFTVILSELPDNHVQKIAQNIIAKLADPFVLGDEMAYVSASVGITFYPNDALEVEQLLRNADQAMYVAKNAGRNRLSYFTNAMQEKAQ
SRLRLLNDLRGALAAGQFLLHFQPIVDLSSGNIRKAEALLRWQHPQRGMVSPLEFITLAEETGLIVDIGDWVFREAARWANRWVDICSD-FQVSVNGSPV
QFQSEAGGIL--DHLQALDLSGQNVVIEITESMLLNADSGITD-LIHFRDAGIQVAIDDFGTGYSSLSYLKKFDIDYLKIDQSFIRDLATDPSDMALSEA
IIVMAHKLGLKVIAEGVETMDQKRLLQEAGCDYGQGYLFSRPLPSSEFE-----------
>tr|S6AIC5|S6AIC5_9PROT Uncharacterized protein OS=Sulfuricella denitrificans skB26 GN=SCD_n02172 PE=4 SV=1
--------------------------------------------------------------------------------RIFSKTFHNSPNPIS-VLVW
TNELFQ--------LFGLDPE--------DSWRGVLDLQPA-DRITDA--IRD-RTALFSEYRGDGEVRWIQALGNAIYDGHGIAVRLSGICIDVTEQKK
TEEKLQLSARVFAEAHEGIVITDASANIINVNPAFCEITGYGREEAIGQNLRIFNSGRQSPEFYTLMMQSLAEEGYWQGEMWNRKNNGVVYAAHLTISIL
RDKLGNAVNYVGLFSDITQAKQQQQTLELMAHYDALTQLPNRVLFADRFKQAINHCKRDKSLLGVCYLDLDDFKLINDTYGHEAGDQMLIELARRIKSSM
REEDTISRQGGDEFAILLGGLDTEQCFNMLERIHQAIAQPYSIDGHVITLGASSGVTIYPLDEAEPDTLLRHADQAMYEAKLDGGNHFQLFDPEHDLQVQ
SYRNQLHIIEEAFARREFCLYYQPKVNMRNGEVVGAEALIRWDHPERGILPPSDFLPVIEGTTLEIKVGHWVIEEALRQMTAWKKTGLE-IKVSINVSPR
HLQGEDFFMA--ALAQFPDIPPQHLELEVLESSAMEDLSLVSRISECHHRLGIKFALDDFGTGYSSLTHIRNLDVSIVKVDQSFVRDMIADPDDYAIVES
VLALSKAFRREVIAEGVETKEHGLILLNMGCTFAQGYAIARPMPPDSMP-----------
>tr|I4B517|I4B517_TURPD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Turneriella parva (strain ATCC BAA-1111 / DSM 21527 / NCTC 1139
--------------------------------------------------------------------------------EIWQFAVEASGEGLWLVEDR
LRALFAEA------PLGIAVINGKF---CLTWKDFTDIAGD--AFMDEIVSGK-RKGFNMVKRGSGGVVWVNMTIAKLSHYHEDRRVHICMVEDITDRIE
SEKRMRLDAAVISHTRDGVVITTLEPKIVSVNQAYCDITGYSADEVVGKNPSILQSGRQDRDFYAAMWREIKSKGRWQGELYNRRKNGEIYPQISTIDTI
YNADGKPEYYVGVFSDISKLKDSEESFERLAHYDVLTGLPNRLMVTNRLAHAVASAGRHRRMVAVLFMDLDHFKNVNDSLGHVAGDELLAAVAMRLKARL
RAEDTIARLGGDEFIVLLEDIESEHAALVARDLLSNLSAPFELAEHEIYSGGSIGISIYPQDGENPHELIRNADAAMYLAKSEGRNTFRFYTQSLTDAAR
KRLALEAALRRALERGELYVKYQPIVDIASGAIVGAEALCRWRTAEGEEISPADFIPVAESTGLIVQVGDFVARTALAVARTWAANQATFKTMAVNFSVR
QFQSHDWYE---HILRESGVAADRVEVEITESDIMQKSEEGIEVIRELHSSGVRIAIDDFGTGYSSLSYLQRFSVNKMKIDQSFVRDLPESAAPISAC--
------------------------------------------------------------
>tr|U7QNM1|U7QNM1_9CYAN Diguanylate cyclase domain protein OS=Lyngbya aestuarii BL J GN=M595_0559 PE=4 SV=1
--------------------------------------------------------------------------------QVMKRAIDSSNNG------N
NPIIFANSGFEKVTGYSREEVLGKN---CRFLQREE---GLVDPVKQAIIEGRSCNQVIQNYRKDGTPFWNDFSISPVHNTKGHLTHFIGIQADITKRKY
YEIALQKKHKISTR-----IYRSLPEMFADYLQAGCKIFDLPMGGITQIEGRFIATHQTQQKQAQAE---------------------------------
--------------------KQVESQLIYEASHDALTHLPNRSFFNEQLRKALQRSKKENYQFALLFLDLDRFKVVNDSLGHLIGDQLLIEIAHRLETCV
NSHDIIARLGGDEFTVLLDNIQSREAVLMAEKIHDTLSQPFYLEGHNIFTTVSIGIVPSCILYNNPEDLLRDADIAMYRAKEKGRSRYELFDLTMQEHTL
ALLRLETDLRHAILGTEFVVYYQPIVKLPTAKVVGFEALVRWIHPTRGLVSPGEFIPLAEETGLIIPLGSWILKQACQQLTIWQQSYDPPLTMSVNLSSQ
QVVQSNLLETIDQILAETNCNPHCLKLEITESIIMKNFQTSVVVLDELRNRGIQLSIDDFGTGYSSLSYLHQFPINTLKVDQSFVRRLQPSSQQIQIIRA
IVTLAHNLDLDVIAEGIETDEQRQLLQELDCEMGQGYLFSKPLNPEQAT-----------
>tr|A0A073CFE5|A0A073CFE5_PLAAG Uncharacterized protein OS=Planktothrix agardhii NIVA-CYA 126/8 GN=A19Y_1824 PE=4 SV=1
--------------------------------------------------------------------------------QLMERAINSSSNG------D
NPIIFVNNGFERITGYSREDILGKN---CRFLQGNN---AVVNKLRRAILEGTECHVELQNYRKDGEFFWNELSIAPVYSSKGYLTHFIGIQADITKRKQ
SEQALVLKHRITTY-----NHQNLDELFRDYLEVGCEIFQLSIGFISRLENRFIAANQTEKQRLKAE---------------------------------
--------------------KQFEAQLMYEALHDTLTQLPNRSFFNERLAQALKRSKQENYQFAILFLDLDRFKVVNDSLGHLMGDQLLIEISHRLLNCV
SALDTVARLGGDEFTILINRVQKSDATSMAEKIHYELTQPFYIQGHEIFTTVSIGIVPSCLLYNNPDDFLRDADIAMYRAKAKGKARYEVFDLSIHSQTL
SILQLETDLRQAIYGKGFKVYYQPIVSLFSGRITGFEALVRWFHPTRGLVSPVEFIPVAEETGLIIPLGAWVLREACQQLQVWKQQLTYPLTMSVNLSSK
QLCQVNLLEQIDQILSETGCNPSDLKLEITESVIMENLSTSFMILAQIKSRKIHLSIDDFGTGYSSLSYLHQFPLNSLKIDRSFISPLDQKSQPLQIVKA
IISLAQNLDLDVVAEGIETREQRRILQELGCPFGQGYLFAKPLEAEQAT-----------
>tr|W6SB25|W6SB25_9CYAN Str. PCC 8005 chromosome, complete genome OS=Arthrospira sp. GN=ARTHRO_40033 PE=4 SV=1
--------------------------------------------------------------------------------KLMERAINSSRNG------D
NRVIFANSGFEKITGYSRHQVIGRN---CRFLQGRD---KALAELRSAIEEGRECNIELKKYRPDGSSFWNELSISPVYNNQGFLTNFIGIQTDISDRKQ
AEANLLSKHRITTR-----LYPSLEARFQDYLQTGCELLQMSTGLIGKISADFLAAQEIEQRQREAE---------------------------------
--------------------KQAQAQLLHAAFYDPLTELPNRSLFNQKLSEALRRSKEDNYQFAVLFLDLDRFKVVNDSLGHVIGDFLLIEIAHRLEICV
TSGDTIARLGGDEFTILMDHIFEKQALEVAEKIHRELSQPFYIEGHEIFTTASIGIVPSCLLYNNPEDFLRDADIAMYHAKERGKARSEVFDLSMHTQTL
ALLQLETDLRKAIFGNDFIIHYQPIVCLITGRIVGFEALVRWRHPRRGLVSPAEFIPVAEETGLIVPLGAWVLEESCRQLSSWKQQLKSHLTISVNLSGK
QLNQLNLIQQIDAILARTNCDPKSLKLEITESMLVENFQTALIVLAQLKARKIHLAIDDFGTGYSSLSYLHQLPLKSLKIDQSFVQRLEEYSQPQQIIKA
IISLAHNLGLEVTAEGIETRQQMQFLHNLGCDYGQGYLFSKPLPAEEAT-----------
>tr|K9VLB1|K9VLB1_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Oscillatoria nigro-viridis PCC 7112 GN=Osc7112_4589 PE=
--------------------------------------------------------------------------------QMMERAIESCSNG------D
NPIIYVNPSFERITGYRRDELMGKN---CRFLQDTD---PAAKQLRIAIEEGRESQVILRNFRKDGTPFWHELSIAPVYNSRRHLTHFIGVQTDITDRQR
SEEELFLNHRITTY-----HYQNFEELVDDYLTAGCLMFGLSMGIMGEVDNKILAVHQMEVERQQAE---------------------------------
--------------------KRVERQLLHGAFHDALTGLPNRVLFIDRLGQAIRRSNQSDYKFGLLFLDLDRFKVVNDSLGHVLGDKLLIALAQRLQTCV
RVSDTVARLGGDEFTILLDHIQSSDATLAAKKIQKELTKPFHLEGHEVFTTASIGIVFSSNSYTHPEEFLRDADIAMYRAKALGKARHEVFNLAMHDQTM
SLLQLETDLRLAILGSHFIVHYQPIVSIASGAIEGFEALVRWHHPVRGLVPPSSFIPVAEETGLIVPLGAWVLREACQQLRIWQKMLTSQLTMSVNLSPK
QLGFPNLIDEIDEILAETGCDPSCLKLEITESAIVENVKKANIVLAQLKGRNIRLSIDDFGTGYSSLSYLHRFPLDTLKIDRSFVRRLGAGGQPLQIVRA
IVTLAHNLGLNAIAEGVETAEQLAQLREIDCELAQGYWFSKPLDSSAVT-----------
>tr|D8G8N3|D8G8N3_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=[Oscillatoria] sp. PCC 6506 GN=OSCI_3960019 PE=4 SV=1
--------------------------------------------------------------------------------QLMERAIASSSNG------D
NPTIYVNPSFERMTGYQRDEILGKN---CRILQRAD---PALKEVRTALNEGKECQVVLKNYRKDGTPFWNELSISPVYNTRRHLTHFVGIQTDITDRKR
SEEELFLKHRITTY-----NYQNFEELFADYLLAGCEIFGLSTGVINQIEGRFLAAHDTEIERQQAE---------------------------------
--------------------KRAQQQLLHDAFHDVLTQLPNRALFIERVGQAIRRSKQQDYKFAVLFLDLDRFKVVNDSLGHSVGDQLLIAIAHRLTSCL
HPSDTAARLGGDEFTVLLEGIQSGDATIIAKKINHEFAQPFNLEGHEVFTTVSIGIVFSCPMYNHPEDLLRDADIAMYRAKALGKARHEVFNLAMHDQTI
SLLQLETDLRRAIQETKLLLHYQPIISLSTGRISGFEALVRWQHPTRGLVSPAEFIPVAEETGLIIPLGAWVLREACRQLRIWQELLKYPLTMSVNLSGK
QLGQMNLFEEIDEILQETGCDPSSLKLEITESVIVENVAKASTMLAQLKARNIRLSIDDFGTGYSSLSYLHRFPLDTLKIDRSFVSRLS-GGRPLQIVRA
IVTLAHNLGLDVIAEGVETKEQLAELQQLECEHAQGYLLSRPLDSEAAT-----------
>tr|A0A0C1QWB9|A0A0C1QWB9_9CYAN Uncharacterized protein OS=Tolypothrix bouteillei VB521301 GN=DA73_0235450 PE=4 SV=1
--------------------------------------------------------------------------------HLMERAIAASSNG------D
NPIIYVNPAFEEITGYPASEILGKN---CRFLQGSE---PALNELRNAILEQRDCHVTLRNYRKDGTLFWNELYIAPVFDSLGFLTHFIGVQTDMTQQQE
ALL----------------------------------------------------------------ERC-HQGIHEMHDFKFQCKDGSPLWAIVSCAPL
FDEQKNYAGALGMVTNITER-----KLVYQAFYDALTGLPNRVLFMERLGQAIAQVKNHENLFAVLFLDLDRFKVVNDSLGHAVGDQLLIAIAQRLQSCL
RQNDTVARLGGDEFTILLSHIQTEDTTLVAERIHQVLKSPFNLNGSEVFTSASIGIAVGTNRYDEPANVLRDADTALYHAKEQGKSGHVVFDTVMYEQAV
ALLQLETQLRWAIERQELRVYYQPIVSVSTGAITGFEALVRWQHPQQGMISPDKFIPIAEETGLIVSIGQWVLREACHQLRQWQKQFPESLSMNVNLSAK
QFSQPNVVKQIGQILEDTNLAPSSLKLEITESTIMASPETAAAVLKQLKAFGIELCIDDFGTGYSSLAYLHRFPIDVLKIDRSFINQIDSDRERLAIVRA
IVTLGSHLGLSVVAEGVETMEQWTQLKLLQCAFAQGYLFSKPLNAEDAG-----------
>tr|L8LH99|L8LH99_9CHRO PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Gloeocapsa sp. PCC 73106 GN=GLO73106DRAFT_00000250 PE
--------------------------------------------------------------------------------KLFKRALDASSNG------D
NPVVYVNQSFTKITGYSSEEVTGNN---CRFLQGKE---PEIEEIRNAIAQGKECYTILRNYRQDGTLFWNELYLTPICDRHGSLTHFLGIQSDITNRKI
AEQ----------------------------------------------------------------LDHQLP--TFTEERRYLHRGGSIVWAQVTVSLV
EEKQSTSPYLIAVIVDITERQTLEQRLIYNAFYDPLTRLPNRILFTELLHDCVEKRRHENYLFAVLFLDVDRFKLVNDTYGHQVGDNLLIYFAHRIKKCL
RHHDTLARLSGDEFAILLDQLTQEDAILVAKDIQARLKSAFYLNGQEVFTSVSIGITFSSIGYQSATDLLRDADLSMYKVKENGRAGYQVFAQNMHDELL
NRVRLETELRKALERKEFCLYYQPILALKTGKIVGFEALIRWKHPQYGLVSPGDFIPLAEETGLIVNMGKWVLAQACQQLQTWQQQYIHSLTMSVNISAR
QLKEPDLVSTVEEILQDTQIDQRLLKLEITETVLMENEAVSIKILEKLQKQGISLCLDDFGTGYSSLSYLHHFPVNVLKVDQSFVQRIGDQSGKIEIIQG
IIALAHSLNMEVIAEGIETRKQFDFLKSSYCEYGQGYFFSRPLDSIAAE-----------
>tr|D8G759|D8G759_9CYAN Putative Diguanylate kinase OS=[Oscillatoria] sp. PCC 6506 GN=OSCI_3790005 PE=4 SV=1
--------------------------------------------------------------------------------RLRDRAIAASNNG------D
CPIIYCNPAFERITGYSQAEIEGKN---CRFLQGPD---AALEELRNALREGRACEVVLKNYRKDGTHFWNKLAISPVRDKKGQLTHFIGVQSDISYRI-
EQESLHQAPGTVSWISSDLRYLGVNHHL-------ARLHGLSPEAFAGKDIAAFTIGIDITERKLAELKTIMSGNSWRGEVTKRTRTGQTIQVLMRADAI
KDAAGKIVGLIGISTNITDRKAAEDQLLHDALHDALTELPNRALLMDRLGQALARARRNNYRFGVIFLDLDRFKVINDSQGHQAGDRLLYAIARRLMSCL
RSGDTVARLGGDEFIILLEEIEDSVAIATANRIQQALEQPLHLEGHKVTVTASMGIALSTPEYQWPGDILRDADIAMYRAKALGKARYQVFAAAMHTHAV
ALMQLESDLRRAVELSPFVLYYQPIVSLSRGIVVGFEALVRWLHPERGLVTPAEFIPVAEETGLIVPLGQWVLREACSQMVKWQKSLKSQLTIAVNLSGR
QFAQPDLIEQIKQVLEETGLDGQYLKLEITESVVMEDGESAVTMLSQLRDLGIHLCIDDFGTGYSSLSYLHRFPINTLKIDRSFVSRMGVDGDNSEIVRA
IVMLAHSLGMDVVAEGVETSHHLAQLRSLGCEFGQGYFFSKPVDSEAAT-----------
>tr|F5UBU5|F5UBU5_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Microcoleus vaginatus FGP-2 GN=MicvaDRAFT_4497 PE=4 SV=1
--------------------------------------------------------------------------------WLCDRALAATSSG------D
CPIIYCNPAFERMTGYCASEILGRN---CRFLQGPD---TTVANIRDALRQGREIQTTIKNYRKDGSPFWSKLSLSPVRDDSANLTHFVGIQSDLSERIC
DHEALQQAPGTVSWISSDLRYLGVNQHL-------AKLHGLRPSAFVGQDIAACLVGIDITERKRAELDTIAQGYSWFGEITKRTKSGKTLQVLLRADAI
KDRTGKIVGLIYMNTDITDQKMAEEQLLHDALHDALTELPNRALLTDRLGQAFARAQRHSYQFAVLFLDLDRFKVINDSQGHRMGDRLLVAVARRLLTCL
RPGDTVARLGGDEFVILLEEIHGEEAIAQAKAILKTIERPLYLEGNKVLITASIGIALSTDQYQWPGDILRDADIAMYRAKALGKARYEVFTSAMHTRAV
ALMHLEHDLRESVEECPFTVYYQPIVCLKSGSVIGFEALVRWLHPERGLVSPMEFIAMAEETGLITPLGLWVLNESCRQIIKWQSL--SPLTVAVNLSGR
QFAEPESIEQIKQVLLETGVDARCLKLEITESVVMEDGEAAAAMLSHLRDLGIGLCIDDFGTGYSSLSYLHKFPINILKVDRSFVTRIGEMGENLEIVRA
IVMLARSLGMEVVAEGVETAAQLAQMRAIGCEYGQGYFFSKPLDSAAAT-----------
>tr|K9QZN6|K9QZN6_NOSS7 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Nostoc sp. (strain ATCC 29411 / PCC 7524) GN=Nos7524_
--------------------------------------------------------------------------------HLMERALAASSNG------D
NPIIYVNPAFESITGYFVQEVIGRN---CRFLQGNA---LGIEELRKALQEQRECHVILKNYRKDGTPFWNELYIAPVFDDSGRLTNFIGVQNDITQHLQ
ALE----------------------------------------------------------------ERR-HQGINETHDFKFLCQDGSDLWAIISCAPL
FDNLGNYSGALGMVTNISDR-----KLMRHAFYDHLTGLPNRVLFMDRLEQAIGQIQQHDQLFAVLFLDLDRFKVVNDSLGHFVGDQLLVSFAERLQNCL
RPEDTIARLGGDEFTILLTQISSDEATRIAEHIHQVLKSPFNLNGYEVFTTTSIGIALSTIGYTQPADLLRDADTALYCAKEQGKAWHIVFDTTMYDRAV
ALLQLETDLRWAIERQELQVFYQPIVSVATGKITGFESLVRWQHPERGLISPAEFIPIAEETGLIIPIGEFVLRESCQQLRQWQLEVPPPLSMNVNLSGK
QFSQPYLVEKIVQILRDVDLEPSSLKLEITESAIMASPEQAATILQQFKALGIKLCIDDFGTGYSSLAYLHHFPIDVLKIDRSFVNRIDRDGERLAIVKA
IVTLASNLGMSVVAEGVETISQLVQLRLLQCDQAQGHLFSPALNSQNIS-----------
>tr|T2J1C3|T2J1C3_CROWT Uncharacterized protein OS=Crocosphaera watsonii WH 0005 GN=CWATWH0005_3856 PE=4 SV=1
--------------------------------------------------------------------------------RSPLSEQGTQSRDIKFDNMK
GKLINVNQSLCQLVGYSEEELLSRG---CVDITHPEKEKKLFNQLLSG---EINSFSLEKRYIINNQIIYGLHQATLIRDIEGKPLYLLGQTIDITQQTH
QNLALQEN-RIISTISDGLLVVNIEGNVRFINEAGVELFGRSSRQLMDHPLAYLVSLRDITENHAAQTQQTSENIARTYDFKFRCRDGRELWTIVSTNPM
FDHSGNYLGSLAMVTDISKR-----QLQYNATHDPLTHLPNRILFMDRLEHAIERQKRHKFTFAVLFLDLDEFKIINDSLGHGIGDKLLREIADRLQYGL
ENDDTLARLGGDEFTILLEDIEDKDAIKIAKSIHLDLMEPFVLEGQDIFINTSIGIALSSSGYEKATEILRDADTAMYRAKADGKSCYAIFDRKMHERAV
NRLQLETDLRIGINKQEFSLYYQPIISLKTGQLTGFEALIRWHHPHKNLISPGQFIPVAEETGLIIPMGEWILKEACQQMKQWHNKFPSHLKIGVNLSSK
QLKYTNLLNMIDSILRETNLDTKSLKLEITETLLMENLQAATEILLNIQEREIEICLDDFGTGYSSLSYLHRFPVNTLKIDRSFVMRMEPNNENAEIVRA
IVHLAHILGLDIIAEGVETELQLEQLEQLGCEQGQGYFFAKPLPSLEVE-----------
>tr|A3IR38|A3IR38_9CHRO Uncharacterized protein OS=Cyanothece sp. CCY0110 GN=CY0110_27490 PE=4 SV=1
--------------------------------------------------------------------------------KLNN-QTKLTNIGSDFDDMK
GQLINVNEAFCQLVGYGAEELLTKG---CADITHPDKEKQLFNQLLSG---EINSFRLEKRYIKNKQIIYGLHQATLIRDIEGNPLHLLSQIIDITQQTD
QTLALQEN-RIISTISDSLLVVNIQGNIRFINDSGIKLFGRSMTELMNHPLAYLVSLRDITENYEAQIQDRSRGITETHDFKFRCRDGKELWTIVSTNPL
FDHQENYLGSLGMITDISQR-----QLQYNATHDPLTNLPNRILFMDRLEHAIARQKRHNFTFAVLFLDLDEFKVINDSLGHAIGDQLLQEIARRLEDGL
CSDDTLARLGGDEFAILLEDIEDKKAIKIAQQIHLDLIKPFVLQGQDIFINTSIGIALNSPAYEAASEILRDADTAMYRAKADGKACYAIFDRQMHERAV
SRLKLETDLRIGINKQEFSLYYQPIISLKTGKLTGFEALIRWNHPHKKLISPDQFIPVAEETGLIIPIGEWTLKEACQQLKIWHQKYPSHLKVGVNLSSK
QLKYTNLLDTIDQTLKDTQLDSRYLKLEITETLLMENLQAATKILLKIQERDIEICLDDFGTGYSSLSYLHRFPVNTLKIDRSFVRLMEPHNENVEIIRA
IVTLAHILGLDVIAEGVETQLQLTQLQRLGCEQGQGYFFAKPLPVHEVE-----------
>tr|A0A0D6AQB7|A0A0D6AQB7_9CHRO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Geminocystis sp. NIES-3709 GN=GM3709_1822 PE=4 SV=1
--------------------------------------------------------------------------------TLLERAINNSTNG------G
NPIIYTNLGFEKITGYSGSEAFGKN---CKFLQGEN---EEVNKLRQAIISQDQTKAILCNYRKNGEQFWNEVYLSPVYNHYGKVTHFIGIQNDITEKYN
IEQSLLKKNNLNN-----INYDTIDNPLNYYLENITNILNIDISIISEYFGRIILREETEL---------------------------------------
------------------EKKIMEEQIFYDAFHDKLTGLPNRFLLMDRLKQFLNRNNKNNSVCAILLIDVDNFKKINDSLGHKIGDELLVLITDKIADCV
RENDTVARISGDEFVVFLPDINSKDSYEIAGKILTACKFNIALHGNTVFSSVSIGITLSSFGYKKSEEMIRDADLAMYQAKESGRNCYRIFNPTMHTDLV
KRLSLESALRKALDKEELELFYQPIINLKTGIIAGFEALIRWNSATHGLISPVEFIPIAEETGLIISLGNWILDTAAKEIKKWENKYPLKLFTAVNVSSK
QLLNPNFLIELDEILATTKVNPYLLKIEITETILMNNYDHAKDILTKIQERNLKISLDDFGTGYSSLSYLHRLPFNTLKIDRAFIQPLIHPQQKNPIVEA
IVTLAHNLSLDVVAEGIETKIQEQILRKINCNYGQGYLYSKPINARNAG-----------
>tr|K9Z5T6|K9Z5T6_CYAAP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cyanobacterium aponinum (strain PCC 10605) GN=Cyan10605_2470 PE
--------------------------------------------------------------------------------YLLRRAIDSCRNG------G
NPIVFVNKGFENITGYSFEEIKGKN---CRFLQKND---TEKKIFREAIQNKESQKIVLRNYRKNGEVFWNEVYISPVYNQEGKVINFIGIQNDITDKYI
TEQKLRKKNKLNN-----LPSQNLQQVFNYYLEEITKILDLDVAIISEVFGRIIISQEIEL---------------------------------------
------------------EKKVMEQQIFYDAFYDKLTGLPNRFLLTDRLKQFFNIRQYDQKLCAILLIDVDKFKKINDSLGHKIGDELLRIIADKIVDCV
TEKDTVARISSDEFIVLLPDITLKEVYNIVEQIRIACLFNTTLQNQEVYSSVSIGVTLSSFGYKKAEEMIRDADIAMYHAKEKGGNCYQIFSASMHTDLL
KRLNLESALVKALENEELELYYQPIINLKTGFIAGFEALIRWHSPSLGFISPVEFIPIAEETSLIIPLGNWILSQAVQQIEKWEKEYPLELFIAVNVSSK
QLLHPNFLDEIDNILEENNINRKLLKIEITESILMDNFDYAKEVLEQIQERNLKISLDDFGTGYSSLSYLHRLPFNTLKIDRIFIQPLTSASVSSPIVEA
IVNLAHNLSLDVVAEGIETEIQEQILKKINCNYGQGYLYSRPVNGRDAD-----------
>tr|K9YI58|K9YI58_CYASC Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Cyanobacterium stanieri (strain ATCC 29140 / PCC 7202) 
--------------------------------------------------------------------------------DLLDKGVNFILNG------D
YPIIYVNDCFLNITGYQKDDVLGKN---YSSLFHQN---YGLENLTSAIARGKETNVIIKNYRQTGELYWSEVYLYPICKQ-KKLTNFIIIERDVTQEYN
YQSSFDISNEIQY-----DLNQDLTTNLSQCLSYACEILGMQIGVVMEVSEKAIIAEEKEL---------------------------------------
------------------EKKNMQEQMLHDSMYDSLTGLANRFLLMDRLAQTLKRCDRNHELCAILLIDIDNFKKVNDSMGHNIGDQLLSIIASKIISCV
SEKDTVARVSGDEFVILLEELESNQARKVAENIINICDTDYYLENHYVASSVSIGITLSSIGYENAEQMIRDADLTMHEAKTVGKNCYQLFKPIMHKELV
QKLQLESYLRKALENNELELFYQPIINLKTSQVAGFEALIRWFHPELGFISPVKFIPLAEENGLIVSLGDWIFRTAAFQAKQWQDKYPLNLSVAINVSSK
QLLEHDFLGKIDRCVAQTGVNPLLLKLEITESVLMDNFQTAKYILDNIQTRHLKISLDDFGTGYSSLSYLHALPFNTLKIDRAFIESINREHERNAIVEA
IVSLAHNLSLDVVAEGIELPIQEEILKEIGCDYGQGYYYAKPMSASLAD-----------
>tr|Q55576|Q55576_SYNY3 Slr0359 protein OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=slr0359 PE=4 SV=1
--------------------------------------------------------------------------------LLLQQAIDASSNG------D
NAVVYANQGFETITGFNREEVIGQN---CRFLLNEDEQNKQLEKLRTAIAHGQECEVVLKNYRKDGASFWNHLYLSPIYNQQNFLVNFIGIQTDVTQQKL
AEQQLRAS-SMIVTITDGLLIVDQEGIIQFVNPAAREMFKRQEGELLQQPFAFLVSLRDITEQHQARPRCVLPNHGQVYDVQFQRRDGSVLWGLVSRSAW
YDQWGNYRGELAMLTDITKR-----KLHYNANHDSLTNLPNRSMFLDRLGHALQRNLRRDLRFAVLFLDLDGFKIINDSLGHSCGDLLLQGIAHRLRQCL
RPEDTLARLGGDEFTMLIENITCEDVIAVAQRIHQELQKPFNLNGQEIFTNTSIGIALNHPHYGHPQDVLRDADTAMYRAKAAGKGRYAIFNQTMHHHAV
QRLQRENDLRRAIDRQELQLHYQPIVCLKTGQLQGVEALVRWQHPEEGLILPEEFVAIAEETGLIVPMGDWILWEASRQILELKQSFPSHLQVSINVSSR
QLRDQRLLKTVDEILSSTNLAPQDLKLEITESLLIDNLNLAADVLKSLRQRNIQISLDDFGTGYSSLSYLHRFPINTIKVDRSFVNTMEPNNQNTAIVHT
IVTLAHTLGLDVIAEGIETERHLTQLHWLGCDAGQGYYFARPIPSEDLL-----------
>tr|W0RJQ7|W0RJQ7_9BACT Diguanylate cyclase OS=Gemmatimonadetes bacterium KBS708 GN=J421_2111 PE=4 SV=1
----------------------------------------------------------------------------GRYAALVETLRR-SEARFRAVSIQ
NRIVFWNAAATRMFGYAEAEAMGQPLLI-PTTTHGTRTP--SPMWQGTAPTLVGRTVELEATRRDGTAFPIELSLSSWY---ADGALYFSIIRDVTARHR
AQEAVRESEQLVECSP--ECIVVHAGVILFANPAAAELLGVRGAYELVGRRLLKVVHPDRDEVRERIARAPDSRSGAQLEFRMLTADGRTLEVETSSVAV
VHDGR--RAVQTHVRDVTPRKALERQLVHEAFHDPLTGLANRVLFRNRVEHALARASRTGPRPVVLFLDLDDFKRVNDGWGHAAGDRLLVQVASRLRATL
RDVDTCARLGGDEFAVLLDEPAGEGAAHVAERIVASLGEPVECDGVALEVGVSIGIAAAA-AADGADELLRNADLAMYRAKAAGKGRYEVFEPAMHAAVR
ERLELEADLRRVVANEDLVVHYQPIAALAGRRLHGFEALVRWRDARRGFVPPLAFIPLAEETGLIVAIGRHVLETACRDARGWQDRLGRPLSITVNLSAR
QLLEPDLPRVVAAALSDSGIAPESLVLEMTESMLIDDTESTLGRVRALKALGVRLAIDDFGTGFSSLAYLERFPVDLLKIDKRFVDRVGREHDESPLARA
ILGLGAALGMRVVAEGIETEAQWTRLRELGCELGQGYYLARPAGLDDVERLLDAEL----
>tr|B1Z7B4|B1Z7B4_METPB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacterium populi (strain ATCC BAA-705 / NCIMB 13946 / BJ
----------------------------------------------------------------------------AVRTELMQAMFGATGQGLMAVGGD
FKIVAANQGAAEIFGRAIATLQWQRLLV-PARLGVTGLL--AGILGR-----DRAVFELASPRSDGTVLHLKVEARAIG------DLIAAM--------T
DIGDIKAREFLFENNPLPMWLVDGTARFVAVNEAAITHYGFDREAFL-ARRLPDLSEAG-AP---------S--LSRDGLHRHLRADGSVIEVTLFERSL
AFEGR--PAVLGAAIDVTEQRRAEARITHMAHHDALTGLPNRALFAVRLAEAIAEHARTGVAAALLCLDLDKFKFVNDTLGHPAGDALLRQVAERITACL
RREDLVARLGGDEFAVLLRNPDAT-VDTIAGRIIEALSRPIRLGDRECQIGVSVGFARLPEHGTESDILLRNADLALYRAKAEGGSVAHGFEAAMDSWAR
SRRRRETDLHEAFARGELALAYQPVLGVRSRAILGFEALLRWQHSVEGAIPPSDFVPLAEETGLIVPIGAWVLRQACAEASLWAD----PIRVAVNLSPV
QFRDPGLVATVREALALSGLAPQRLELEVTESVLLAASEANVATLHALRQLGVRIAMDDFGTGYCSLSYLQRFPFDTIKIDRSFVNRLGDDPHSTAIVRA
VIGLGASLGIVTVAEGVETEAQFAQLRAEGCGEVQGYLFGRPAPAAEARRLIRREP----
>tr|C7CKB3|C7CKB3_METED Methylobacterium extorquens DM4 str. DM4 chromosome, complete genome OS=Methylobacterium extorquens (strain DSM 5838 / DM4) GN=
----------------------------------------------------------------------------GVRTELMQAMFGATGQGLMALGAD
FKIVALNQGAAAILGRPVASLQWQRLLV-PVRLGVTQRL--SGVLGC-----DRATFELAVPRADRTTLHLKVEAQAIG------DLVAAM--------T
DVGDIKAREFLFESNPLPMWLVDQSARFVAVNEAAVAHYGYSREAFL-ARGLQDLSEAV-AF---------S--FARDGLHRHRRADGSLIDVTLFERSL
AFEGR--PAVLGAAIDVTEQRRAEARITHMAHHDALTGLPNRALFTTRLAAAITEHARTGAGAALLCLDLDKFKLVNDTLGHPAGDTLLRAVAERITACL
HGEDLVARLGGDEFAVLLRTPDAT-VSAVAGRIIEALSHPVRLGDRECQIGVSIGIACLPEHGTDSDTLLRHADLALYRAKADGGSIAHCFEAAMDSWDR
SRRRREADLHEAFARGDLALAYQPVVGVRSRAIVGFEALLRWHHPVEGAIPPSEFVPLAEETGLIVPIGAWVLRQACAEASLWAD----PVRIAVNLSPV
QFRDPGLVATVREALAFSGLAPHRLELEVTESVLLAASEANVATLHALRDLGVRIAMDDFGTGYCSLSYLQKFPFDKIKIDRSFVSRLGEDPHSTAIVQA
VIGLGASLGIVTVAEGVETEVQFAHLRAEGCEEVQGYLFGRPIPAPQAVGPIRREP----
>tr|B1M3H8|B1M3H8_METRJ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / 
----------------------------------------------------------------------------SVRTELVQAMFTATDQGILALSAD
FKIVALNRGAERLLERPAAALQWQRVLF-PGAITARATL--AAMVER-----GRSAFELSRPRSDGGTLYLKVEAGCVG------DLLSTM--------T
DVGDIKARELLFENNPVPMWVVADRDRFLAVNDAAVAHYGYSREQFL-SRAPADLAIAAEAT---------E--LGLPAGSLHRRADGSAIEVSLFQRAM
PFEGR--QAVLEAAIDMTERRRAEARIAHMAHHDALTGLPNRVLFRDRLGEAIARHARDGEEAVLLCLDLDKFKIVNDTLGHPVGDALLREAAERIAGCL
RKDDLVARLGGDEFAILVRGMDLALADGLIARVIAELGRPFRLEGQDCHIGTSIGVACLPRDGTDPETLMKNADLALYRAKAEGGSTFRCFEPEMDAWVQ
ARRRRENELREAFARGQFSLVYQPLMDARSDRILAFEALLRWHHPEHGPVSPAEFVPLAEETGLIVPIGAWVMQTAFAEAATWPE----TIRLAVNLSPI
QFRNRTLVETVRGALAATGLDPRRLELEITESVLLADSAANLATLHALRDMGIRIAMDDFGTGYSSLSYLRSFPFDKIKLDRSFVSQVGENTHCTAIVRA
VASLGTSLGIATTAEGVETPEQLAMLRAEGYDEVQGFLFSRAVPGPEARRLIDRAR----
>tr|A0A0C6EZS5|A0A0C6EZS5_9RHIZ Methylobacterium aquaticum DNA, complete genome, strain: MA-22A OS=Methylobacterium aquaticum GN=Maq22A_c12575 PE=4 SV=1
----------------------------------------------------------------------------TVRTNLLKTLFRSTRQGMAAVTGD
FRILSLNDAAAAMMRTTIERAQWRRLLL-PAATVGPARL--NAAL-S-----DRRHYETSYTRPDGSPLHVRVEIAAIG------DLLGTL--------T
DIGDLKARELLFEHNPVPMWLSG-DGAVLAVNDAATGHYGFPREDFL-RLSAGDLAMPGAGP-----------------AQRHRRRDGGVIDVEVFSGPI
PFEGL--SATLTACVDVTEQRRAERRIAHMAHHDALTGLPNRVLFHERLAALVA----ERAPAGLLCLDLDHFKLVNDTLGHPAGDALLRQVAERLRACL
GGHGLVARLGGDEFAVLHRAER-ALVAL-ADRIIAALCRPFALDGQDVTVGVSIGIALAPEHGDDPDGLLRKADTALYAAKADGRRTRRLFEPAMDAALQ
ARRALERDLRAAIAAEALEVHYQPLVDARTLAVTGCEALLRWRHPERGFVSPADFIPVAEETGLIASLGEWVLARACREAAGWPR----PVRVAVNLSPV
QFRAPDLVGTVARALTESGLDPARLELEITEQVMLEESAANIAVLHRLRGLGVRIAIDDFGTGYASLSYLRAFPFDKIKIDRSFTAALGQEAAALAVVQA
VIGLGASLGTTTVAEGVETEAQLAVLRRSGCDEVQGFLFSRPVPAADLRALVAAPA----
>tr|B0UNP6|B0UNP6_METS4 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacterium sp. (strain 4-46) GN=M446_2712 PE=4 SV=1
----------------------------------------------------------------------------TSRTNLLKAILRATGQGILALSED
FQVVALNEAAAEMIGG-PAALMWQRLIL-PGPVAEAARL--RPIAGA-----GRLSFEAAYRRADGAVLHLKIEAASLG------DHLGTL--------T
DIGDVKARELLFETNPLPMWVTD-AGRFLAVNDAAIGHYGYASPDFL-RMSLRDLAVAGAGS---------G------EPARHRRRDGSVIEVAAYSRRI
PFEGR--SATLTALVDVTERRRAEARITHMAHHDALTDLPNRVLFRQRIVAALEAQARDGRSAGLLCLDLDRFKLVNDTLGHPAGDELLRQAAQRLASCA
Q-DGSVARLGGDEFALLAPADG-EAVMATARRVIALAQQPFLVAGQAVQVGASVGVALLPADGTDPDVLLRRADMALYAAKAAGRGTAVAFEPAMDEAIQ
ARRILEADLRAALEAGALEVHYQPLHDCRTLRILGCEALLRWRHPARGFVPPGEFVPLAEDLGLIGELGAFVLRAACREAAGWSV----PLRVAVNLSPA
QFRSPGLALSVTAILAETGLDPRRLDLEITETVLLSEDAANVAILSELRALGVRIAIDDFGTGYASLSYLRAFPFDQIKIDRSFVGRLGEDPQSAAIVRA
VTDLGRSLGIVTVGEGVETPRQLEQLRAFGCDVVQGYLLGRPVPAAALRPLLAA------
>tr|W3RHE6|W3RHE6_9BRAD Diguanylate cyclase OS=Afipia sp. P52-10 GN=X566_23635 PE=4 SV=1
----------------------------------------------------------------------------GTRYNLIDAIFGSTSEGILALASD
FQILDLNKGACHLLRSRMDELRFRRIGH-PILSKPEERM--QSVLET-----SRQQFEVTVPKG-EGLSYLQISVGAIG------DLLATL--------T
DITDVKRRELLFDHNPMPMWVFDATHRFLSVNDAAVSHYGYSRDGFL-TMRLQDIWPRDWETHLAAINEFGD--VYQSSSWRHVKADGSEIEVLTRGRRI
AFDNR--DAFLVTAVDITDRKKAEARIAHMAHHDALTDLPNRVLYRERLEAALARAH-AQSSVAVLCVDLDLFKNVNDSFGHSMGDQLLRCVAERLRQSL
RESELVARIGGDEFAIILDKVQGNDVSARAAALIEILSERYLIDGVELVIGASIGVALAPGDGDSADQLLRNADMALYRAKSEGRGSHHFFEVDMDHQAQ
RRRTMEADLRQALARSEFELHYQPLIDLAAGQITGFESLLRWRHPVHGMISPGDFIPIAEDIGLIVPIGEWILREACTEATHWPA----SVKVAVNLSPA
QFRSRNLVQTVVSALAHSGLEPKRLELEITESVLLAETETNLATLHQIRALGVSISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVSEVTERPDCVAIIRA
ISGLGRSLGITTTAEGVETTAQLDCLRNEGCMEVQGFLFSPARPASEARQLIARFG----
>tr|Q07P60|Q07P60_RHOP5 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodopseudomonas palustris (strain BisA53) GN=RPE_2334 PE=4 SV=
----------------------------------------------------------------------------GGRYNLLDAIFAATDDGILSLAAD
FQIVHLNQGAARLLGQPAAALQWSQLGA-HLLCTAEDWL--LQRVGG-----DREELEIDSD-----DRNLSLSATAFE------DMLSTI--------S
DVTSLKRRELLFDNNPMPMWVFDATTRFLKVNDAAVRHYGFSRSAFL-GMKLPEIWPADREAHLHALQQAGD--NYLSDNWRHLKADGSEIEIIAFGRRV
AFERS--DGFLVAIVDVTERRKAEARIAHMAHHDGLTNLPNRSFYQERLQHALEA-RPAECHVAVLCVDLDLFKNVNDSFGHPVGDRLLQLVAERLRLEV
RGANMVARLGGDEFAIVLVSVVSNEASDFAARVIERLSVPYDVDGLEVVIGASIGIALSPGDGDNGEDLLRNADMALYRAKESGGGNHHFFEKEMDRQAQ
KRRDMEIDLRYAFAKGQFELYYQPLVDVARDRVAGFEALLRWRHPERGMISPADFIPVAEDIGLIVGLGEWVLRQACAEAATWPS----EIKIAVNLSPV
QFRSRNLVQAVIGALAQSGLSPRRLELEITESVFLAETEANLATLHQMRDLGVRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVQDLAQRPDCLAIVRA
IAGLGRSLNITTTAEGVETQAQLDWLREEGCNEVQGFLFSPARPAGEIAALIARFG----
>tr|Q212L9|Q212L9_RHOPB Diguanylate cyclase/phosphodiesterase OS=Rhodopseudomonas palustris (strain BisB18) GN=RPC_3125 PE=4 SV=1
----------------------------------------------------------------------------GAQYNLLDAIFSSTDDGILSLAAD
FQIVHLNEGASRLLGEPSTALQWSRLGG-HLLCSPMARL--LNVISS-----NSDVLEIDRG-----QQTIRLSATAFG------DVVSTV--------S
DVTSLKKRELLFDNNPMPMWVFDATTEFLSVNDAAVQHYGFERESFL-RMKLQDIWPEDREVHLRSVLQVGD--THYSGNWRHLRADGSEIEVLTFGRQV
AFEGR--DGFLVAVVDITERRKAEAKIAFMAHHDGLTNLPNRGSYQEHLHQALELSRRCNSKVAVLCVDLDLFKNVNDSFGHPTGDRLLQKVADRLRQQV
GGNDLVARLGGDEFAIVLGAINSNEASDFAAKLIEILSVPYDMDGPEVVIGASIGIALSPGDGDDGEELLRNADMALYRAKAEGGGTHHFFEREMDRQAQ
KRRDMEIDLRRAFTKGEFELYYQPLVNLAEDRITGFESLLRWRHPERGMISPADFIPVAEDIGLIVGLGEWVLRQACAEAVKWPS----DIKVAVNLSAV
QFRCRSLVQVVIAALAQSGLSPTRLELEITESVFLADTEANLATLHQLRELGVRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLADRPDCLAIVRA
ISGLGRSLNITTTAEGVETLDQLDWLRAEGCNEVQGYLFSAARPSGEINDLLLRFG----
>tr|A0A0D7EG30|A0A0D7EG30_RHOPL Diguanylate cyclase OS=Rhodopseudomonas palustris GN=OO17_20350 PE=4 SV=1
----------------------------------------------------------------------------GSRYNLLDAIFSSTDDGILSLTSD
FQIVHLNDGAARLLQRTVEALQWSQLGT-HLLCCPTERL--LKVVGT-----DGAVFDIDSH-----DRNFSLSATAFG------DIVSTI--------S
DVSFLRKRELLFDNNPMPMWVFDITTAFLSVNDAAVQHYGYERRRFL-GMALRDIWPRDWETHSQALVSFGE--SYQSDHWRHLKADGSEIQVLTFGRRV
VFNGR--DGFLVAVVDVTERRKAEARIAYMAHHDGLTNLPNRALYQETLQRALEQATRAGTNVGVLCIDLDLFKNVNDSFGHPTGDRLLQMVAERLKQEV
GGNDMVARFGGDEFAIVLSPVASNDASDFAMKLIERLSAPYDMDGLEVVIGASIGIAMSPGDGVEDEELLRNADMALYRAKAAGGGVHHFFEKEMDRQAQ
LRRDMELDLRRAFARGEFELHYQPLVDLAEDRITGFECLLRWHHPERGMISPADFIPVAEDIGLIVGLGEWVLRKACAEAMTWPA----DIKIAVNLSPV
QFRSRNLVQVVIAALAQSGLAPRRLELEITESLFLAETEANLATLHQLRQLGVRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVQDLAQRPDCLAIVRA
ISGLGRSLKITTTAEGVETVDQLDWLRAEGCDEVQGFLFSAARPAAEIKALLLKFG----
>tr|Q2IY43|Q2IY43_RHOP2 Diguanylate cyclase/phosphodiesterase OS=Rhodopseudomonas palustris (strain HaA2) GN=RPB_2161 PE=4 SV=1
----------------------------------------------------------------------------GLRYNLLDAIFSSTDDGIVSLTSD
FQIVHLNEGASALLQQSVNALQWSLLGR-NFLCEPAARL--LALVDS-----GQDSLSIDTD-----NRNLSLGVTAFG------DIVSTI--------S
DITSLKKRELLFDGNPMPMWVFDATTEFLNVNDAAVQHYGYDRDAFL-RMTLREIWPRDWAAHSLALLQVGD--SYQSGNWRHLKADGTEIQVMTFGRRV
VFNDR--EGFLVAVVDVTERRKAEAKIAHMAHHDGLTNLPNRALYQERLQQALEQARGGGGRVAVLCIDLDLFKNVNDSFGHPMGDRLLRCVADRLRAQI
GGNDLVARLGGDEFAVVLASVASNEASDVAARLIELVSAPYDMDGLEVVIGASIGIALAPGDGDDCDVLMRSADMALYRAKAAGGGCHHFFEKEMDRQAQ
RRRDMERDLRHAFARGEFDLHYQPLIDLAEDRVSGFEALLRWHHPERGMVSPADFIPIAEDIGLIVGLGEWVLRQACLEAARWPN----DVKIAVNLSPV
QFRSRNLVQVVISALAQSGLSPRRLELEITESLFLADSEANLATLHQLRSLGVRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLTERPDCLAIVRA
IAGLGRSLNITTLAEGVETVEQLDALRAEGCHEVQGFLFSPARPAAEIAGLLMKFG----
>tr|K8P0I3|K8P0I3_9BRAD Diguanylate cyclase (GGDEF) domain-containing protein OS=Afipia broomeae ATCC 49717 GN=HMPREF9695_02535 PE=4 SV=1
----------------------------------------------------------------------------GAQYSLLDAVFSAADDGILSLAAD
FQIVHLNQGTARLLKLPPDELRWHRLGT-HALCSPQQRL--CAAVKG-----VSEQFEVSDH-----DSTLKISAAPVG------DLLSSL--------T
DVTDLKRRELLFDSNPMPMWVFDVTRRFRNVNDAAISHYGYDRDRFL-SMELQDLWPKDWEEHSRALVGVGE--VYNSGNWRHLKADGSEIEVLTFGRRV
SFEGR--DSFLVSAVDITERRKAEARIAYMAHHDGLTNLANRVMFQERLRHDLERSRQVNKCVAVLCIDLDLFKNVNDSFGHHTGDKLLTLVAERLAADA
RQDNLVARLGGDEFAMILGGDLSNEVSARAIQIIETLSEPYQIDGLEAVIGASIGIAISPGDGDTGEELLRNADMALYRAKSEGGGVHHFFEKEMDRRAQ
TRRDMEIDLRRALATGEFQLHYQPLVDLAQDRIVAFEALLRWHHPVKGMVSPADFIPVAEDIGLIVPLGEWVLREACMQAAAWPS----DIKVAVNLSPA
QFRSRSLTQTVFSALAQSGLSPLRLELEITESIFLADSEANLATLHQLRDFGVRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVRDLAERPDCAAIVRA
ISSLGRSLNISTTAEGVETMDQLDRLRDEGCTEVQGFLFSAARPASEIAALLGKFG----
>tr|A0A087M664|A0A087M664_9RHIZ Uncharacterized protein OS=Devosia riboflavina GN=JP75_05340 PE=4 SV=1
----------------------------------------------------------------------------MEKYSLVDAIFASTTGGLMALARD
FRLVALNQGAADLVSQSIDALRWQRLLF-PHLRGTGDQL--VQAWRT-----AAVEFEFSYPSALGGVRYFSMRASAME------DLVSSL--------I
DVTEIRNRELLFQDSPLPMFVYCPTMQMRDVNAVAVEHYGYSREQFL-SMSLLDIRPQERERVRQILAQPTI--PSDTGIWKHLKADGSIIEVRVYSRQV
DYQGQ--AARLAVVVDVTEQRKTEARISFMAHHDALTALPNRVLFLDELRRTLRHVERHEQPAAILCIDLDYFKDVNDTLGHPVGDKLLQQVSGRLRGAL
RENDLVARLGGDEFAVIQRDLAEGEAGMLSDRLIAVLSQPYDVDGQMVVIGASIGIAMAPTDGESADALLKNADMALYRAKDEGRGTFRYFQPEMDARVK
ARRALEVELRGALVVGEFTLRYQPFVSVETGKITGFEALLRWNHPERGMVPPIEFIPLAEDIGLIVPIGEWVLRQACRDAAEWPE----DMRVAVNISAV
QFKGQKLANLVASALTMSGIEPGRLELEITESVLLHDSEANVAVLHQLRALGVRISMDDFGTGYSSLSYLRSFPFDKIKIDQSFVREIVDNSGDAAIVSA
VVGMGVSLGISTTAEGVETAEQLERLRAEGCTEVQGYYLGRPMPAGEAQKLMARQS----
>tr|B3QE43|B3QE43_RHOPT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodopseudomonas palustris (strain TIE-1) GN=Rpal_3890 PE=4 SV=
----------------------------------------------------------------------------AQRYNLLDAIFSSTDDGIVALTPD
FQIVHVNQGASQLLRHPVSELRWSRLGH-HLLCSADGRL--IELVDS-----ASVTFAVDSG-----DRNLSVSATAFG------DVVSTI--------S
DVTSLKKRELLFDGNPMPMWVFDASFEFLSVNDAAVAHYGYPRERFL-RMSLREIWPREWIAHGQTLLEMRD--SYQSENWRHIKADGSEIHVLTFGRRV
LFDGR--DGFLVAVVDITERRKAEAKIAHMAHHDGLTNLPNRALYQQRLEQALAQARGSGTMVAVMCVDLDLFKNVNDSFGHPMGDRLLQCVAERLRQQI
GDGDLVARLGGDEFAIVLTSLATNEASSFAARLIEILSAPYDMDGLEVVIGASIGIALAPSDGDECEALSRNADMALYRAKAAGGGCHHFFEKEMDRQAQ
IRRDMELDLRQAFARGEFELHYQPLIDLAEDRIGGFETLLRWRHPERGMISPSDFIPVAEDIGLIVGLGEWVLRQACLEAASWPS----DVKVAVNLSPV
QFRSRNLVQVVISALAQSSLVPHRLELEITESLFLADSEANLATLHQLRSLGVRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLTQRPDCLAIVRA
IAGLGRSLDITTLAEGVESVEQLDVLRAEGCHEVQGFLFSAARPASEICGLLMRFG----
>tr|Q134K2|Q134K2_RHOPS Diguanylate cyclase/phosphodiesterase OS=Rhodopseudomonas palustris (strain BisB5) GN=RPD_3263 PE=4 SV=1
----------------------------------------------------------------------------GFRYNLLDAIFSSTDDGIVSLTAD
FQIVHLNDGASALLRQPVEMLQWSRLGR-HMLCEPAARL--LALVDK-----GQDTIAIDSD-----DRNLSLGATAFG------DIVSTI--------S
DITSLKKRELLFDGNPMPMWVFDATTEFLSVNDAAVQHYGYDRDAFL-RMTLREIWPRDWASHSHALLHVGD--SYQSGNWRHIKADGSEIQVLTFGRRV
VFDGR--DGFLVVVVDITERRKAEAKIAHMAHHDGLTNLPNRALYQERLQQALEQGRAGGARVAVLCIDLDLFKNVNDSFGHPMGDRLLRCVAERLRAQV
GGQDLVARFGGDEFAIVLAQVTSNEASDFAARLIEIVSAPYDMDGLEVVIGASIGIALAPGDGEDCDALLRNADMALYRAKAHGGGCHHFFEKEMDRQAQ
IRRDMELDMRHAFARGEFELHYQPLIDLAEDRISGFESLLRWRHIERGMISPADFIPIAEDIGLIVGLGEWVLRQACIEAARWPD----DIKLAVNLSPV
QFRSRNLVQVVISALAQSGLAPRRVELEITESLFLADSEANLATLHQLRSLGVRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLTERPDCLAIVRA
ISGLGRSLNITTLAEGVETIDQLQALRGEGCHEVQGFLFSPARPACEIDGLLMKFG----
>tr|H0T8Z2|H0T8Z2_9BRAD Uncharacterized protein OS=Bradyrhizobium sp. STM 3809 GN=BRAS3809_6730001 PE=4 SV=1
----------------------------------------------------------------------------AAQYNLLDSIFSTTEDGVVSLASD
FQVVHHNQSAATLLKLSPAELQWRRLAG-TMLGSTDARL--FAVVTD-----GRDQFELDCD-----DRNLRLGVHAFG------DIVSTV--------S
DVTALKRRELLFDANPLPMGIFDTTGRIMKVNAAAAEHYGYDRERLL-GMTIWDLWPESTTDPGEAMARLTA--RDDFHEWRHYTADWSLIDVLAYGRRI
SYEGR--DGFLVAIVDITERRKVEARIAHMAHHDGLTNLPNRELYQERLKQALQPGPAGPKPIAVLCVDLDLFKNVNDSLGHPMGDRLLQAVADRLRERV
HGCNLAARLGGDEFAVILADAPSSDASDVAAKLIQALSAPYEIDGHELVIGASIGIALAPSDGSTSEELMRNADMALYRAKEEGGGVHRFFEKEMDLQAQ
KRRDMEHDLRQAFAEGDFELHYQPLVDVATSTISGFECLLRWRHPEKGMISPAEFIPVAEDIGLIVPIGEWVLRQACREAATWPD----GITVAVNLSPV
QFRSRNLVQVVVQALAQSGLAPERLELEITESILLAETEANLATLHQLRGLGIRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLAQRSDCLAIVRA
ISGLGRSLNITTTAEGVETPDQLDSLRAEGCNQVQGFLFSAARPASEIAGLLARFG----
>tr|U1H7W0|U1H7W0_9BRAD Diguanylate cyclase (GGDEF) domain-containing protein OS=Bradyrhizobium sp. DFCI-1 GN=C207_00489 PE=4 SV=1
----------------------------------------------------------------------------NDQYNLLDTIFSATDEGVLSLAAD
FQIVHLNQGAARLLMQPATELLWRRLGG-NPLAAPPNRL--RGFVGS-----PGGQFEIDSG-----DRCLRLGVTAFG------DMLSTV--------S
DVTALKQRELLFENNPMPMWVFDATMEFLSVNDAAVQHYGYSRERFL-GMTLREIWPEDRGVHSAALREIGD--VYQSSDWRHIRADGTEIHVLTFGRKV
AFEGR--DGYLVAVVDITERRAAEARIAHMAHHDGLTNLPNRDFYQERLREALERGRSGNKRVAVMCIDLDLFKNVNDSFGHPMGDRLLKLVAERLREVV
RDDNVAARLGGDEFAIVLAADVSNEASAFAERLIDALSAPYQIDGLEVVVGASVGIALSPGDGTTSEELMRNADMALYRAKSEGGGVHRFFEPEMDLQAQ
KRRDMERDLRAAFSNGEFELHYQPLVDIAANRISGFESLLRWRHPQKGMISPAEFIPVAEDIGLIVALGEWVLREACAEAMKWPA----DVKVAVNLSPV
QFRSRNLVQAVISALAHSGLPARRLELEITESVFLAETEANLAILHQLRELGVSISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLARRADCLAIVRA
ISGLGRSLKITTTAEGVETTDQLDWLRAEGCNEVQGFLFSAAKPGSEIAGLLSKFA----
>tr|A0A099IYY0|A0A099IYY0_9BRAD Uncharacterized protein OS=Bradyrhizobium diazoefficiens SEMIA 5080 GN=BJA5080_06236 PE=4 SV=1
----------------------------------------------------------------------------GTQYNLLDAIFASTDDAVISLAAD
LQIVHHNQSAATLLKVASAGLLWRRIGN-TLLAASDEFL--LKAVRG-----RGEQLEIEHE-----GRHLRLSATAFA------DVLSTI--------S
DVTALKRRDLLFDNNPMPMWVFDATKQFLGVNDAAVQHYGYSRAAFL-RMKLHEIWPEDWDSHAEALDRVGD--TYHSSNWRHLRADGSEIEVLTFGRRV
AFDDR--DGYLVAVVDITERRKAEARIAHMAHHDGLTDLPNREYFQERLKQALDQ--AGGKRVGVLYIDLDLFKNINDSFGHPVGDRLLKEVAERLTTAV
RGANLAARLGGDEFAVILAADVSNEASACATLLIDMLKAPYEIDGQEMVIGASIGIALSPGDGVTSEELMRNADMALYRAKSDGGGVHHFFEREMDLQAQ
KRRDMELDLRRAFANGEFELHYQPLVSIASDRISGFESLLRWRHPDKGMISPAEFIPVAEDIGLITQLGEWVLREACSEAVKWPV----DVKVAVNLSPA
QFRSRNLVQVVISALAQSGLSPKRLELEITESIFLAETDANLAILHQLRELGVGISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLAQRPDCVAIVRA
ISGLGRSLNITTTAEGVETEDQLDWLRAEGCNEVQGFLFSAARPAAEIEKLLADFG----
>tr|A0A0D7NJI5|A0A0D7NJI5_9BRAD Diguanylate cyclase OS=Bradyrhizobium sp. LTSP885 GN=UP09_26755 PE=4 SV=1
----------------------------------------------------------------------------DAQYNLLDTIFSATDEGVLSLAPD
FQVVHLNQGAARLLMQPATDLLWRRLGG-NPLAAPEERL--REFVRR-----GGGQFEIDSG-----DRCLRLGVTAFG------DMLSTV--------S
DVTAMKRRELLFENNPMPMWVFDATMEFLSVNDAAVQHYGYARKKFL-GMTLREIWPQDWALHSEALREIGD--VYQSSDWRHIKADGSEIHVLTFGRKV
AFDGR--DGYLVAVVDITERRAAEARIAHMAHHDGLTNLPNRDFYQERLCEALERSRSGNKRVAVMCVDLDLFKNVNDSFGHPMGDRLLKLVAERLRAAV
QGDNLAARLGGDEFAIVLAADVSNEASAFAEQLIAVLSAPYAIDGLDIVVGASIGIALSPSDGMTTEELMRNADMALYRAKSEGGGVHHFFEPEMDQQAQ
KRRDLERDLRAAFANGEFELHYQPLVDIAADRISGFESLLRWPHPQKGMVSPAEFIPVAEDIGLIVALGEWVLREACSEAVKWPS----NVKVAVNLSPV
QFRSRNLVQAVISALAHSGLSPRRLELEITESVFLAETEANLAILHQLRELGVSISMDDFGTGYSSLSYLRSFPFDKIKIDRSFIKDLARRSDCLAIVRA
ISGLGRSLNITTTAEGVETIDQLDWLRAEGCNEVQGFLFSAARPAGEIGALLAGFA----
>tr|D6VAJ2|D6VAJ2_9BRAD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Afipia sp. 1NLS2 GN=AfiDRAFT_3626 PE=4 SV=1
----------------------------------------------------------------------------GLDFDLLDAVFCATDDGVLSLAAD
FQIVHLNQGAARLLRLPSDELRWLRLGT-HLLSFTNAQL--AEATGA-----ANVQIEVEGD-----GFTLKLNVAPVG------DMLSIL--------T
DITDLKRRELLFDANPMPMWVFDATKNFLNVNDAAIRHYGYDRATFL-GMNLLDIWPEDRQAHASVLDEVGD--IYQSTNWRHMKADGSKIEVLTFGRRV
PFEGK--DGFLVTAVDITERRRAEARIAYMAHHDNLTGLPNRVKFREHLDQALERSDGSDERIGVLCIDLDMFKNVNDSFGHPVGDRLLKMVAERLHAVI
PADSLVARLGGDEFAMIVKRNPMRDLNDLSAILIADVSAPYAVDGLELVIGASVGIAMSPGDGVTGDDLLRNADMALYRAKSEGGGAHCFFEQEMDRQAQ
TRRALEFDLRHALANGEFELHYQPLVDVAANRIVAFESLIRWRHPERGMVSPAEFIPVAEDIGLIVTLGEWVLREACTEAAKWPA----DIKVAVNLSPI
QFRSRNLVQTVIAALAHSGLAPTRLELEITESLFLAETEANLAMLHQLRSLGVRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVRDLAEREDCVAIVKA
ISGLGQSLNISTTAEGVETEDQLERLRAMGCTEVQGFLFSAAKPGVDIAGLLDRFG----
>tr|A5EM05|A5EM05_BRASB Diguanylate cyclase/phosphodiesterase OS=Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) GN=BBta_5207 PE=4 SV=1
----------------------------------------------------------------------------SAQYNLLDAIFSTTDDGVISLASD
FQVVHHNRAAAELLRLPSSDLQWHRLGG-HVLCGPDARL--FEVVAH-----GSDQFELDSD-----DRNLRLGVHAFG------DIVSTI--------A
DVTALKRRELLFDANPMPMCILDGTAQILNVNDAMLRHYGYSRADLL-CMNVWDLWPPGWGAVDDALTRLAD--GDLFHDCRHCKADGSEIEVLTYGREI
NYDGR--DGVLMAIVDITERRRAEARIAYMAHHDGLTGLPNREFFQQRLAQELDEAASGARPLAVLCIDLDLFKTVNDSFGHPMGDRLLQAVAGRLKQQM
HGGNLAARLGGDEFAAIVSQDGA-GSGEFAARLISVLSAPYDIDGNELVIGASIGIALSPLDGTSCEELMKNADMALYRAKQHGGRVHRFFEREMDLQAQ
KRRDMEHDLRRAFAQAEFELHYQPLIDVASNIISGFECLLRWRHPDKGMISPAEFIPVAEDIGLIVPLGEWVLREACHEAATWPD----GIKVAVNLSAV
QFRSRNLVQVVMQALAQSSLAPERLELEITESILLAETDANLATLHQLRQLGVRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLAQRSDCLAIVRA
ISGLGRSLNIITTAEGVETSEQLDWLRAEGCNQVQGYLFSAARPAAEIAGLLARFG----
>tr|H0SR92|H0SR92_9BRAD Uncharacterized protein OS=Bradyrhizobium sp. ORS 375 GN=BRAO375_730011 PE=4 SV=1
----------------------------------------------------------------------------AGQYNLLDSIFSTTEDGVVSLASD
FQVVHHNRSAASQLQLSAEELQWRRLGG-TMLGTPDARL--FAVVTQ-----GRDQFELDCE-----DRSLRLGVHAFG------DIVSTI--------S
DVTALKRRELLFDANPLPMGIFDSTGRILKINAAAAEHYGYDRDCLL-QMTIWDLWPESTANLDEAMARLTA--RDDFHEWQHYKADGSLIDVLAYGRRI
RHDGR--DGFLVAIVDITERRKVEARIAHMAHHDGLTNLPNRELYQERLRHALQPGGAGSRSMAVLCVDLDLFKNVNDSLGHPMGDRLLQAVADRLREQV
QGGNLAARLGGDEFAVILADVASNDASDFAARLIQALSAPYEIDGQELVIGASIGIALAPSDGSTSEELMRNADMALYRAKEEGGGVLRFFEKDMDLQAQ
KRRDMEHDLRHAFAQGEFELHYQPLVDVATSTISGFECLLRWRHREKGMISPAEFIPVAEDIGLIVPLGEWVLREACREATRWPD----DIKVAVNLSPV
QFRSRNLVQVVVQALAQSALQPERLELEITESILLAETEANLAILHQLRGLGIRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLAHRSDCLAIVRA
ISGLGKSLNITTTAEGVETSDQLDWLRAEGCNQVQGFLFSAARPASEIAGLLARFG----
>tr|M4Z9Y9|M4Z9Y9_9BRAD Diguanylate cyclase/phosphodiesterase OS=Bradyrhizobium oligotrophicum S58 GN=S58_46520 PE=4 SV=1
----------------------------------------------------------------------------TTQYNLLDAIFSTTDDGVVSLASD
FQIVHHNRAAADLLRLPSATLQWHRLGG-NMLCSPEARL--FKVVGL-----QRDQFELDCD-----DRSLRLGAHAFG------DIVSTI--------A
DVTAMKRRELLFDVNPVPMCILDRTAQFLNVNDALVRHYGYGRPDFL-RMSVWDLWPPGWETLDDALSRLAD--SNEFHDWRHRTADGSEIEVLTYGREI
AFDGR--DGVLVAIVDITERRRAEARIAYMAHHDGLTGLPNREFFQQRLTQELDGAVLENKHIAVMCIDLDLFKTINDSFGHPMGDRLLQAVAGRLRQQM
HGDHLAARLGGDEFAVILGRTGA-EASASAAHLISALSAPYDIGGNELVIGASIGIALSPGDGASWEELMKNADMALYRAKQDGGRVHRFFEKEMDRQAQ
KRRDMEHDLRLAFAQGEFELHYQPLVDVATTAISAFECLLRWHHPDKGMISPADFIPVAEDIGLIVPLGEWVLREASHEAAKWPE----GIKVAVNLSAV
QFRSRNLVQVVMQALAQSALAPERLELEITESILLAETEANLATLHQLRQLGIRISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLAQRSDCLAIVRA
ISGLGKSLNIITTAEGVETSDQLDWLRAEGCNQVQGFLFSAARPASEIAGLLAQFG----
>tr|H0TDA4|H0TDA4_9BRAD Uncharacterized protein OS=Bradyrhizobium sp. STM 3843 GN=BRAS3843_1070042 PE=4 SV=1
----------------------------------------------------------------------------SAQYNLLDAIFSTTEDGVVSLAAD
FQIVHHNQSAARHLKLPSSRLQWSRLGG-NILCAEDMRL--FDVVSR-----GHDQFEVDSD-----ERNLRLGAHAFG------DIVSTI--------A
DVTALKRRELLFDANPVPMCIFDKTAEILNVNDAAVRHYGYSRAQFL-RRTIWQLWPPGWESLDQALEDLAE--TDHFQDWRHLKADGSEIEVLTYGRRV
TFDGR--DGFLVSIVDITERRKAEARIAYMAHHDGLTGLPNREFYQERLKQALEQGAAGNKRVAIMCVDLDLFKNVNDSLGHPIGDRLLQAVANRLKEQA
RGGNLAARLGGDEFAVILNDAGTSNISEFAADLIEVLSAPYEIEDQELVIGASIGIAVSPYDGSSSEQLMKNADMALYRAKQDGGRVHRFFETDMDRQAQ
KRRDLEHDLRHAFAHGEFELHYQPLVDVASNRISCFESLLRWRHREKGMISPADFVPVAEDIGLIVPLGEWVLREACSVAAKWPD----GIKVAVNLSAV
QFRSRNLVQVVMSALAQSGLAPTRLELEITESIFLAETEANLATLHQLRQLGVSISMDDFGTGYSSLSYLRSFPFDKIKIDRSFVKDLAQRSDCVAIVRA
ISGLGRSLNITTTAEGVETVDQLDWLRAEGCNQVQGFLFSAAKPASEVEELLVRFG----
>tr|A0A085EVD4|A0A085EVD4_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia sp. LC238 GN=FG94_04522 PE=4 SV=1
----------------------------------------------------------------------------RQTLFEVQAIMQNATIGIMY-TRN
RIIQ-YNPAFARMFGYRDGEALGRSTSW-HDFGATA------QLARG-----IPYR------A-DGLNGY--LF--------NPLGTIW-LFEDR----H
DEIQLRN-LAILDNAVLGIAVV----VTLHCNSKMEELFGSPAGGMDGTPVRAL--DEAWKLARLDTARSFGAGQVHT-EYLMARRDGTPFWARLSGRLF
DADQELAGANALLQEEIAERRQAEARVHHMAYHDSLTGLPNRALLSDRLECALRAA-QRN-KLAVMFLDLDRFKTINDSLGHATGDQLLREAARRLGTAV
RDSDTVARLGGDEFVVLLPEVGGRECAQVADKIIDLLATPYPFEGRSLHITPSIGICLCPDDGKDVDTLMRHADAAMYHAKAAGRNNYQFFDQRMNQAAT
RRFELESQLRGALAREEFELHYQPIVDTGTRRLHALEVLLRWRRDGENVVGPDEFIPILEENGMIVPVGEWVVQSACEQCIAWQRQ-LLAVPLAINLSAR
QFMHDALVSSIRRIVGETGIDPALVEFELTETALMQHGGQTLDILRQINGMGMRLSIDDFGTGYSSLAYLKRFPVRKIKIDRAFVRELEASAEDRAIVAA
VMALANSLGLSVVAEGVETEGQVALLAGYGCQFAQGYLFARPLPALEAARLLDASV----
>tr|K9DPR3|K9DPR3_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia timonae CCUG 45783 GN=HMPREF9710_03944 PE=4 SV=1
----------------------------------------------------------------------------RQATGEVQAIMTNASIGIMF-TRN
RVIR-ANPAFCQMFGYGEGEPIGVSTAY-RQLGAEA------QLAQG-----RPFT------T-DGMIGY--QV--------NAKGTIW-MLEDR----S
DEQSLRE-LAILDNAVLGIAVV----RTLHCNRKMEELFGAPPGGMDGIAVRAL--DHAWKEARELSGRQFAQGQAHM-EHEMVRRDGSRFWARLSGRLF
DLAQELAGANALLQEEINERRQAEARVHHMAYHDSLTGLPNRAMLSERLEAAMRAVAPHA-KLALMFIDLDRFKNINDTLGHMVGDQLLRDVALRLVTAV
RPSDLVARLGGDEFVVLMPGIAGGDAAEVAGRIIAALSMACQIDGHCLHISPSIGICLYPDDGVDVETLMRHADAAMYQAKAAGRNNYQFFTERMNLAAA
RHFELESSLRGALAREEFALYFQPIMCTETRRPSALEVLLRWRRGG-ALVGPDEFIPILEESGMIMEVGEWVIRSACAQAVQWQRE-LDVVPLAINLSAR
QFMHQGLVDSIRAIVADTGIAPGLVEFEITETALMQHGGQTLEILRQINAMGMRLSIDDFGTGYSSLAYLKRFPVRKIKIDRAFVRELEASTEDRAIVAA
VMALAGSLQLSVVAEGVETEGQYALLRSFGCQYAQGYLFARPLPAEQVARLLAG------
>tr|D3NVN5|D3NVN5_AZOS1 Uncharacterized protein OS=Azospirillum sp. (strain B510) GN=AZL_018260 PE=4 SV=1
----------------------------------------------------------------------------RRSEERYALAAAASNDGLYDWDLV
TDRV-YSPRWASLLGLSPAE---LTDEW-LGRILPA-TD--AMAFLGGGDPNAAFQVEYRMRNAAG-------VLD--AA--GKVG----SQADK----T
AEQRLRQ-ELAAAGAADGL----YESGEVYYSPRWKAMLGFGEAEIAGSIEEWFVPGDLGLRTAID-LHLSGERPHLQ-EFRIRDKAGLELWMLVRGLAV
RDDRGGAVRMAGSMTDITAGKKAEQQILFDAVHDSMTGLPNRTLMLDRIGQALDRNRRAGAPFAAIILDLDRFKAINDALGTSAGDRVLRIVAKRLDASR
RVGDTLARLSADEFAVLVDDLDDGEALAAAERMARAISRPVMLEGRDVVLTASIGVALSQTGYDRAEDMLRDASLAMYRAKSGGRARIDLFDANLRRQAM
TAMRMEADLRGAVEQGHLCLHYQPIVLLETGAIAGFEALMRWNHPDRGLVPPAEFIPLAEETGLIAPMGRWALEQAVRQLAAWQARPPVPLFMSVNVSIR
QFRDDDIVGAVRDLLDAVPIPPSSLKLELTESLLVQDPDECRMLLQSLRDMGVRLSIDDFGTGYSSLAYLHKLPVNVLKIDRSFVRALSTGEGNAAIVQV
IAGLATILRLDAVAEGVETAEEAVYLRGL-CKYAQGYHFARPAPPEAVERLLAAEG----
>tr|G7Z7P9|G7Z7P9_AZOL4 Putative Diguanylate cyclase/phosphodiesterase with PAS/PAC domain OS=Azospirillum lipoferum (strain 4B) GN=AZOLI_1729 PE=4 SV=
----------------------------------------------------------------------------NTNIDRYLLAEKAGSEGVWDWDLR
SDTL-LSPRFKDFLGLPPGDPSRETNDW-LSLVHPE-HA--SFEA--MVGLSVPFQIEHRVRRDKA-------VMD--DL--GYVG----SVADK----L
AEQRLRQ-ELAAAGAADGL----HDSGEVYYSPRWKAMLGYGDAEIGDTVDEWFLPGDLGLRSAID-LHLTGERPHLQ-EFRIRDKAGAELWMLVRGLAV
RDDRGCAVRMAGSMTDITARKKAEQQILFDAVHDAMTGLPNRTLLLDRIGQALDRNRRVGAPFAAIIIDLDRFKAINDALGTSAGDRVLRIVAQRLDISR
RVGDTLARLSADEFAVLVDELDDGDALEAAERMARAISRPITLEGGDLVLTASIGVALSQTGYDRAEDMLRDASLSMYRAKSGGRARIDVFDANLRRQAM
AAMRMEADLRAALEQGQLCLHYQPIVLLETGAIAGFEALMRWNHPDRGLVPPAEFIPLAEETGLIAPMGRWALGEAVRQLALWQARPPAPLFMSVNVSTR
QFRDDDLVGAVRDLLDAVPIPPSSLKLELTESLLMQDPDECRMLMQSIRDMDVRLSIDDFGTGYSSLAYLHKLPVDVLKIDRSFVRAVSTGEGNAAIVQV
IAGLATILRLDAVAEGVETADEAVYLRGL-CKYAQGYHFARPAPPDAVERLLAAED----
>tr|G1Y4M5|G1Y4M5_9PROT Diguanylate cyclase OS=Nitrospirillum amazonense Y2 GN=AZA_75482 PE=4 SV=1
----------------------------------------------------------------------------RLTLERYSLAAAASNEGLYDWDLR
TDRV-YGETWKALLGYAEDE---IGSEW-LNRVDPD-QA--TLDAQA-SAGGKPFQIEYRITHRNG-------VLD--DD--GEVG----AQRDK----N
AEEQLRL-ELAAQGANDGL----HATDQLYCSPRWTAMLGIGGGARTSTMEDWYDGEDRRLRAAVD-THLAGGSAHLE-EVRTRHAGGAELWVLIRGVAI
RDEEGEAIRMAGSMTDITARKRAEQQLLFDAFHDGLTRLPNRMLLLDRIGQALGRRRRPEEQFAVMIFDIDHFKTVNDSLGPLVGDEVLCAVGQRLDGAR
RSGDTVARLSADEYGVLMDGVLDKAAVDAAERLASAVAEPLTLNGQEVVMNVTAGIALSGSGYASAGDMLRDAGLAMFRAKTSGRNRVEMFDDALRERAL
TRLRLESDLRHAVEGRQFRLFYQPIVRLADGTVAGFEALMRWFHPERGMIPPSDFVHLAEETGLILKMGRWALVEATRQLAEWQGRS--DLFMSVNVSGR
QLMEDDLVAAVTETLDTHRITPGTLKLEITESLLLDDPGRCLGIMEALKRKDVKLSLDDFGTGFSSLSYLHRYPIGTLKIDRSFVRAAGESDRRSAIARI
ITLLAQALDLEVIAEGIEKEAEADFLRGLHCQFGQGFHFAPPLPKEAVEDLMDARR----
>tr|K2IWI0|K2IWI0_9PROT PAS/PAC and GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Oceanibaculum indicum P24 GN=P24_11822 PE=4 SV=1
----------------------------------------------------------------------------ERYAGMLQNTLENISQGIVAYDDE
MRMT-WNERYAQLVDLPPQFRMVGTP--------ID-AQ--R----GDYGPGDPEELAMATFRRNG-------IRT--TP--IPVA----TFTEK----A
SEEALRR-ELAAAGANDGL----DKENRIFFSRRWKEMLGYNDQEIGDAPEEWFHPSDVQVTAQLD-AHLAGASSHFE-EHRMLHADGRYHWMLIRGQAV
RDMAEKTQRIAGSQTDITSRKIAEERVQHDALHDTLTGLPNRTLLTDRLRQALARSRRSGQRFAVLLIDLDRFKVVNESMGHLRGDELLVSLALRLGEKV
RAGDTLARLGGDEFAILLEDVTSDEALAFARDVLDTVSQPFQLDGKEIVSTASIGVAMWDPSYGKAEDILRDADLAMYSAKSDGKAQVALFHANMHKRAV
AMLDLENDLRRALDRDEMLLHYQPIISLDSGKIVGVEALVRWHHTDRGVLSPLDFIPLAEETGLIVPIGEWVLRRACEQMAHWHREPRPPLQVNVNLSSR
QFAKTDLVDSVTQVLAETALDPARLKLEITESALMENAQRSAHILEQFKRRDIQLSIDDFGIGYSSLAYLRTFPIDTIKIDKSFIIDMVTNRDNLEIVRT
IAALAQNLNLDVIAEGVEAPDQLAQLRALGIEYAQGYLFSRPLDTAAITALLRQNP----
>tr|T2G931|T2G931_DESGI Putative PAS fold family OS=Desulfovibrio gigas DSM 1382 = ATCC 19364 GN=DGI_0784 PE=4 SV=1
----------------------------------------------------------------------------IRHREQLGTVLGAMTSLVVEVDNR
GTAL-VHPTASPYRTATP--ANGAAL------TDPQRLE--AAHRSG-----TPQQAELEVC-EES-----------------VDGRHL-VARDH----D
ARRAMARQRALVQHAADGVAVV--EGAINYLSPGMHAALGLQTPPPQGVGFETLD---DDAFLRQMAVVLPQPGKTAR-ETQILKACGDDAILEIHAANL
LHE-PDVAGVVLNCRDITCQRRYQEELRRQAFCDPLTGLANRPLFMDRLEHAMARMARKE-SYAVLAIDLDRFKRVNESLGHDNGDQLLLRVGQILKGCM
RKVDTLARLQGDDFVVLLDEIGDLEVIRVAVRIRDALAQPHLVDGVEISLRSSVGIVYGDYTCTCPEQVLRDAETALRWAKTHGCDGYKVFHAAMHKQTM
AQLEMEADIRKGLDRNEFSLHYQPIVSLETNRVVGMEALLRWNHPLRGAIPPMQFIPVAEESGLIVPLGERVLTLALAQAVRVRALLEQPFYVSVNLSPR
QLVHKELSTMVQRALERARLPAGVLKLEVTESLVMENPAQARAILKDLQDLGCRLAIDDFGTGYSSLSHLCQYPFDTLKIDRSFVSLLEDNLRHEGIVQA
ILHMAQSLDMHVVAEGIETPAQIQTLTRLGCRTGQGYFFASPMDAPSLEAFLTRTP----
>tr|A0A0A1H8Q9|A0A0A1H8Q9_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Burkholderiales bacterium GJ-E10 GN=E1O_25040 PE=4 SV=1
----------------------------------------------------------------------------QREMELMQFITDHLAEGVS---ER
GRLV-VNKAFVESLGYARDAVLSMRISW-PRHWEDL--------KRN----S--LTFETTHRTRSG---C-----------------AY--VRYK----T
MEQEVRIAA----ESQVGMLIT-DNANILRVNGAFTRITGYSAAEVIGRNPRILHSGRQ-PDFYKALWQGVEDSGYWSGLW-NRRKNGELFAEHLTITAV
KDGDGRVTNYVGSLSDITPTKKTEEEIQRLVLYDPLTNLPNRRMLMDRLQVALAAAARTGRAGALLFIDLDNFKIVNDTRGHAVGDWLLQQVGNRLASEV
REDDTVARLGGDEFIVMLQNLAVQRAAAVAEKIIRSLAVPFVSAESRFLCTPSIGVTLFQDGRAPPEELLKQADIAMYEAKKSGRNTLKFYDRKVQEAIT
ARVTLEAELRRAIEANEFALHYQVKVDR-RGQPVGAEALIRWCHPARGIVPPAQFIPLLEETGLIIPAGLWILDTACRQVKRWEERDTRDLVLAINVSAK
QFHQPDFVDQVRKVVARHAIDPQRLELEITESVLLDDTEAVIAAMRALRQYGVRLALDDFGTGYSSLNYLRKLPLNVMKIDQSFVQELGPDTSEGAIVQT
IIAMAKILDLVVVAEGVETRSQKQYLDDWGCARYQGYLFGRPMPIEQFEASLPGRS----
>tr|G3J1J8|G3J1J8_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_4225 PE=4 SV=1
----------------------------------------------------------------------------NRYLNLYEF----APVGYL---PE
GKII-INLTAAALLGVERNNLVNRHFRW-HRLLKNI--------LEH----GEQKNFELM---------CLPVITDDQT----PVLRIT--LTDK----R
AEEELRIAA----EAQEGIMIT-NDKVMLRVNRAFTDITGYSAEELVGQMPHMFKSGRH-ETFYAEMWECINRTGSWQGIW-DRRKSGDIYPKWVTITAV
KDSDGTVTHYVGLHTDISTRKASEEVIKQLAYYDPLTALPNRRLLMDRLQQALAASARSKKYGALLFIDLDNFKSLNDHLGHDMGDVLLQQVAQRLIDCV
REGDTVSRQGGDEFIVMLEDLSGTKAKTIGEKIITSLNQAYQLTSHEYRNTPSIGITLFINHQHEINMLLKRADIAMYGAKAAGRNTLRFFDQNMQEAVT
ARAALEADLRFALTKNQFRLYFQRQARH-DGQTIGAEALLRWKHPKRGFVSPLEFIPLAEEIGLIIPIGQWVLETACAQLKRWESHPTCNLQLAVNVSAH
QFHQPDFTEHVFAILNKTAIKAHRLKLEFTESLVFDDIDDTIAKMQVLKKIGVSFSIDDFGTGYSSLTYLTQLPFDQLKIDQSFVRNIGVKSTDTVIVQT
IIGMATNLGMDIIAEGVETEEQLAFLELHGCHIYQGNLIGKTMPQEEFERSLGI------
>tr|T0BUK5|T0BUK5_9BACL Uncharacterized protein OS=Alicyclobacillus acidoterrestris ATCC 49025 GN=N007_11320 PE=4 SV=1
----------------------------------------------------------------------------IQFDYTIETLLNTLPDFIAFKDGE
GRWI-ANPVALEVFHLTNVDYVGKRDMM-EALRHCETRQ--GETVRG-----KE----------DGFDTIKIPTFYPDGR--RKVGRDI----DR----K
DLEQSRQ--SLYHDNPNPT----DSGRITTVNAKMETLLGYTANELVGRTTSFLEDVSREEF-----FRETLLGNRHV-EIGVVTKSGRQIQLEVHGVPM
I---GEVVGIYGVAQDVSDRTRAEQIIYHLAFYDPLTGLANRAMLTNRISDAIADLG--A-ALAVLFIDLDHFKSLNDTRGHSMGDLLLKRVAQRLQACV
PASGTICRLGGDEFIVLLPRLKECEAITVAKRILDTFSEPWDLGGECVYITGSIGIAMGTDNTVDAEQLIRNADMAMYDAKDKGKNTYRLFDSSLSEKLQ
RKVELETALRQALAQDMFTVCYQPQFDMATRRIIGAEALLRWNHPR-GVYPTNELIQVAEETGLIVPIGLWVLRTVCRQAKQWREA-HHPLRIYVNVSPR
QFIDNRFVHHVQQILAETGMDGHALGLEITEGVIMRDVHYAQETLQALRDMGMKIDIDDFGTGYSSLAYLKRFPIDRIKIDQSFIRDVTNNEADLAIVKT
IISLAHNFQIPAIAEGVETATQFQLLKQHGCDEAQGYFLGRPANSEDFNTHLGTAH----
>tr|J2UG53|J2UG53_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Polaromonas sp. CF318 GN=PMI15_00324 PE=4 SV=1
----------------------------------------------------------------------------QRLATRLGITLESITEGFY---PQ
WRFS-LNREGARLLGRPPTELLGKSI---------I--------N-----------------TLFSLDKWFEIRAYPFP----DGLAIY--FRDR----K
AREQLMLLE----SRLNDIVLIGRGLRIIFANNAFEQHTGYSLAEALGHSPRLLCGPLT-RGELERIRNAFQKGEPVQALI-TYKKNGRHFWMEVDIVPV
ADDAGVFTHWVAVGRDITRRKVAESEIKHLAFYDPLTQLPNRQLLMDRLDKALVHNRRHPREGALMFIDLDNFKTLNDTMGHQKGDLLLQQVAKRLAACV
RQTDTVARLGGDEFVVMLEDLGQPKAEIVSGQILAALSEPYSLAGYQHYSTCSIGVTAFNQTLNNIGDLLKQADLAMYQAKMAGRNTVCFFNPAMQAAVT
ASAALQSDLRRGLREKQFLLYYQPQVGR-DGRMTGVEALLRWQHGERGLVQPAEFIPAAEDAGLILPLGQWALETACRQLAAWAQRPTAALSIAVNVSVR
QFRHPEFVDLVMAALKETQVSPHKLKLELTESLLAEDMEITITKMARLKKMGVTLSLDDFGMGYSSLSCLKRLPLDQLKIDKSFVEDILRDPNDAAIART
IIGLAQSLGLGVVAEGVETEAQRDFLSRHGCDCYQGYLFCKPLPIDELEAFIKTLR----
>tr|Q123Y8|Q123Y8_POLSJ Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Polaromonas sp. (strain JS666 / ATCC BAA-
----------------------------------------------------------------------------HRLATRLSITLENISEGFY---PE
WRFT-LSREGERLLGRPGTELLGKSI---------I--------N-----------------TAFGMDRWFEVRAYPYP----DGVAIY--FRDR----K
AREQLMLLE----SHLNDIVLIGKGLRIIFANNAFERHTGYGRNEALDQSPRLLCGPLT-RSELDRINKAFLRGEPVQALI-TYRKDGKHFWMEVDIVPV
ADDAGVFTHWVAVGRDITRRKVAESEIMHLAFYDPLTQLPNRQLLMDRLQQALAHPPQLPREGALMFIDMDNFKTLNDTLGHHKGDLLLQQVAERLTGCV
RTADTVARLGGDEFVVMLENLGHPRARAVGEQILAALSEPYLLAGYQHYSTCSIGVTSFNQNHDSIGDLLKQADLAMYQAKTAGRNTLCFFDPVMQAAVS
ASAALQSDLRQGLREKQFLLYYQPQVGR-DGRMMGAEALLRWNHPVRGMVPPADFIPVAEESGLILPLGQWVLETACRQLGAWAQRPTAALSISVNVSVR
QFRHPEFVDLVMAALNDTKVSPHKLKLELTESLLADDMEITIGKMAKLKAMGVTLSIDDFGMGYSSLSCLKRLPLDQLKIDKSFVADILRDPNDAAIART
IIGLAQSLGLGVVAEGVETEAQREFLYRQGCESYQGYLFCKPLPIEALEAFMKNPA----
>tr|E1VKZ7|E1VKZ7_9GAMM Uncharacterized protein OS=gamma proteobacterium HdN1 GN=HDN1F_19060 PE=4 SV=1
----------------------------------------------------------------------------QQ---ELRELTEHLPVAIYHYQGT
PRLI-ISDNVERIMGIPAAEMIASSAAF-IEAD-----------RKT-----------SQHLLNFS--RWLHVKSSPYRL--ADGQVTYGIIEDK----Q
TEERSLQSEQIFDTSNAGIFLV-NEGIITLANRRMSELFHCPHEQLIGSKYVAHIHPDDEAGQQKMLDLIASEIDSVDLRL-YWREDGSQFWGNLCGRRF
KNADGTTAGLLGLIMDVTDRHQAEEEIRTLAFYDPLTQLPNRRLLLDRLQQGMTASARSQLHGALIFIDLDNFKSLNDTLGHDVGDQLLVSVARRLQTCV
REGDTVARLGGDEFIVMLTEIHGTIAETIGHKIISALNKPYSIGTHELRSTPSLGIALFLGHDTSVDEMLKRADMAMYQAKAVGRNTLRFFDPQMQARVN
ARAHMEAELYRAIEQQEFMLFYQPQINA-TGDCTGVEALLRWQPTAQSMISPAQFIPIAEETGQIIAIGGWVVLEACRQQAIWQKNPTRHLNVAINISAK
QFQHSSFVHDLHEAIQQTGADPKHIKLELTESILLADIREATQKMATLGGLGISFSVDDFGTGYSSLSYLKLLPLQQIKIDQSFVRDILNDPNDRAICQA
IIALGKALGLSVIAEGVESSPQWKMLLSDGCSEAQGYLFAMPLPAKEFTTWLNTKN----
>tr|C1D1W4|C1D1W4_DEIDV Putative diguanylate-cyclase OS=Deinococcus deserti (strain VCD115 / DSM 17065 / LMG 22923) GN=Deide_1p00099 PE=4 SV=1
----------------------------------------------------------------------------LARTQEYTDLLESITDAFYVLDRD
WRFV-VNTYAQRLLGKSAEELLGQVK--------SVSYR--EAMRSG-----VPQKFE--------LELWAEAHLYPSA-------RGLVSFQDK----A
TERAERQRRTPLEQVLHEVALL-QPGVSVLLRQEIDGLLIGPDQGSCGTSAFSRV------------THDIAASPAWA-FREL---AGIHGLCSCMSLPV
LDEH-QLVRARDLAALAMRHHQLTAQLRHQAQHDALTGLPNRSLFTERLAEILEQSERS--STALLFVDLDEFKGVNDTVGHHVGDYVLQAVADRLLGCA
RRGDVVARVGGDEFTLVLPFAEEPHAITVARRVLNELTRPFVVQGRAFHLGASIGISVSPQAGRDGQTLLRHADLAMYRAKRE-KSGFAVFEAQLNQQAQ
LRLQLASDLREALREANLELHYQPQVRLHDGQVVGAEALVRWRHPHLGMVSPAQFIPVAEDTGMIVPLGTWVMEEACRQAVAWAAA-HGAMRVAVNVSAL
QFARPDFVDTVSATLRATGLEAGRLEVELTESAVMEDVKESVERMERLRALGVSVAVDDFGTGYSSLSYLQRLPLNVLKIDRTFIQNLGVNATSRSVVQA
IVGLAQHLNLECVAEGVETPDEREALIEVGCRYAQGFFFAKPLPAPALLEWLSQAD----
>tr|I4N6A4|I4N6A4_9PSED PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Pseudomonas sp. M47T1 GN=PMM47T1_07631 PE=4 SV=1
----------------------------------------------------------------------------MAEQKVMRASLALSEDRLRRLF-A
VWILDSSQANAAMLGF-SDPVTFKNIGT-PSVERAD-AV--MSAA----RAKGVQRFEWTHRRLDGSLFPAEVTLSVMG---LDGEPVTAVVRDR----E
AETELLRQKVIVDNAPSLIYMFDPGR-LVLCNQLEADLLGKRRDEFMIPADALQ-------QNNDDTSVLIS-GQAHRFDIHHRRGEPRTYLTTKCPLRT
PDGQL--LGVLGISNDITRLKQTQAALERLAHFDSTTGLANRVLFHRRLGEDIDTAGTHGRQLAVLVLDLDGFKTVNDTLGHPTGDRLLQAATLRFQRAL
RPGDMVARLGGDEFAFVLPINRHEEITARLQALLDSLRPAFELDGSTALITASIGVALYPADGACADTLLRHADTAMYAAKEAGRNDYRFYQRHMTLHMQ
TRVSLEHALRRALDCDELEVWYQPKVNLADGQVMGVEALMRWRDPVAGLIPPTDFIPLAERTGLIVPMGEWLLDQVCAQIRQWRDRGCFEGHVAINVAVP
QIERSDFADTVTRALQRYQLPARTLEVEVTESLFLESRQLARSVLSRLQGMGVTTAVDDFGTGYSSLAYLHLLPVDNLKIDRAFIQELPHSATHVAITRA
IIQLGHALKFHVTAEGIETPEQYEFVRQAGCDVGQGYLIARPMPAAEFEVWLARAP----
>tr|E4PJJ3|E4PJJ3_MARAH Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Marinobacter adhaerens (strain HP15) GN=HP15_1415 PE=4 
----------------------------------------------------------------------------NREEERFRSTIDSSPVATVMVDQA
GIIQ-ANQLAHSLFLYPRNHLVGKPL------REEH-RG--FMN--------APQQRMM----GEGAEI---------AL--NPEGRYIASVMDL----K
AEEKILRLRLTVEEGELLAAMI-NDSGTVLNQHASNRPLSKAETAIVG---------------------------------ECLQNHRIVIKNELRKPDY
NRGFG---DISFA----IANLAKSHQLEYLTHFDSVTELPNRLLFTDRLQQAILQAEWR--VFSILYVDIDRFRQVNDSLGHTVGDYVLCKVAERILACV
AEADTVARWGGDEFIVLLPDRSGADASEIATCINGQLHSVISLNGRELFVSCSMGIAECDGTGIDVDVLINRARTAMATIKEQGGNDYRHFIASDHGTLS
DALALETSLRHALEERQLELYYQPQIDIASRQLVGLEALLRWQHPTEGLVPPDHFIPLAEKTGLIIPIGKWVLYEACRQAAAI-----PGLRVAVNLSAR
QFHQENLVTVVQEVLDKTGMPPAYLELEITESALIYEVEAAIDTMSQLSSLGVSISLDDFGTGYSSLSYLKRFPIDTLKIDKSFINEVTTDPGSEVIANT
IIAMAHSLNLKVIAEGVETEEQLAMLRERECDQAQGYLIARPMPFSEVIAKFQL------
>tr|M1FJG9|M1FJG9_9ALTE Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Marinobacter sp. BSs20148 GN=MRBBS_3751 PE=4 SV=1
----------------------------------------------------------------------------NCEEERFRSTIDASPVATVMIDQG
GIIR-ANRLVHSVFRYPDHGLVGLSV------RQSH-RE--YMR--------NPTQRIL----GVGAEI---------AL--NPDGRYVAAVVDV----A
AEQKILRLRIAVEDGELPAALI-DNLQEILHGHAETRLLIGPEVDSIR---------------------------------ECVQQNCVVVRNNLAGDPG
DDDPG---DISFA----MANLDKSQELAYLTHFDKVTDLPNRLLLTDRLQQAMLQADSY--NVSILYMDLDRFKQVNDSFGHAGGDEVLRRVAERIGECV
GKADTVSRWGGDEFIVLLPGQSASDAAGVASAISEALHSLIVLGSRELFVSCSIGIAEYLNKSSDVDALINSARSAMSVIKEQGGNNYRHFVSGGDEASD
DGLELETSLRQALGQKQFQLYYQPQIDIVSGRVLGLEALLRWHHPTQGMIAPNRFIPLAEKTGLIIPIGEWVLREACAQVANQ-----HGLKVAVNLSAR
QFHQKDLVAMIRRILDETGMPPANLELEITESALIYDVELAIATMEQLNDLGVSVSLDDFGTGYSSLSYLKRFPIDMLKIDKSFIDEVTTDPDSNVIVKT
IIVMAHSLGLKVIAEGVETKEQLTMLREHGCDQAQGYLIARPLLCQEALEVAAQTF----
>tr|B7K9S9|B7K9S9_CYAP7 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cyanothece sp. (strain PCC 7424) GN=PCC7424_1608 PE=4 SV=1
----------------------------------------------------------------------------KASQKNLQTFIDNTSAAIYLKDLQ
GKFL-VNRQLEKLVGLKREQMIGKTD------IADANQA-------G-----ESLS--------EQYLSVKFPLYDPNGL--LY---------DK----Q
AEEALRQ--NLLD---LAYEAI-DNNVITFWNQGAEQLYGWKKSQALGQVSHILEFNLSPHF-----DAILRLTGHWE-ELTHTRQDGTKIIVESRQVLV
QDDRGQIKGILEVNRDITERKLAQFQLEHNALHDALTELPNRLLLMERIQAAIQRAKRKP-HFALLFIDLDRFKTINDTLGHLVGDHLLVAIATRLQHCV
RSGDTVARLGGDEFIILLDDLLESDAFPITERILGRIKEPLVINNQQIQTSASIGIVFNRDGNESETDLLRNADLAMYSAKEQGKSRYAVFNPTMHLRAH
TLWEIENNLRTALDGQEFLLHYQPIFSLTTQTLVGFEALIRWRHPVRGLISPMDFIPVAEETGLIVPIGEWVLQEACRQLLHWQELPAKCCFMSINLSSR
QLESGNFIAVIDQILQQTPLSAKNLKLEITETLLMKNLEAASALLLELKNRAIGVSIDDFGTGYSSLSYLCHLPVDSLKIDRSFVAKMDKGRESLQVIQA
IISLAHQLNLEVIAEGIETQDHLTQLHHLKCEYGQGYFLSKPLDSEKATQLICSSP----
>tr|F7XBL9|F7XBL9_SINMM Putative diguanylate cyclase OS=Sinorhizobium meliloti (strain SM11) GN=SM11_pC0168 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------GG-VSICSN-----------------DPSRFECRRERE------NAFAAGAVD------CVVKVLTEEVKGRLQ
AQKQLDQRNTTLENIGQGVCFFDAQR-LILSNRRYAEVYGLPPEMIKPGMTLSEVVPHDYLAWCDAI----N--SKSSPDWSMELKSGKAIRVHHE----
-RTSD--GGWVSTHEDITEHRNAERQIARLALHDPLTDLPNRAALKQKLDTLLEQHQKQGTQFAVLCLDLDRFKEVNDLFGHHVGDQVLCLAAKRLCATA
V-GAFVARLGGDEFMVLAEADAS--AAQLADLIITILSEDAEIEGTRIRMGTSLGVAIFPADGDNAAELMGNADAALYRAKADGRGTARFFEPQMDKWLR
ERRALQRDLQAAISQQQLSIVYQPQADIGGD-VIGFEALLRWNHPTRGNIPPSVFIPIAEESSLMIEIGEWVLREACREAAAWPR----KLSVAVNLSPV
QFKHGDLDRLVKSVLIETGLEPERLELEITEGVLIDDLERAISTLGHLKALGVRIAMDDFGTGYSSLSYLQSFPFDKIKIDQSFVRNIGLS-QSSAIIRA
VIGLGRGLDLPIIAEGVESTDQLAFLTRESCDQVQGYLVGRPRPISDYAKYVGRAE----
>tr|C6WMG3|C6WMG3_ACTMD Diguanylate cyclase/phosphodiesterase OS=Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971) GN=Amir_2
----------------------------------------------------------------------------PDPQVVVGFVIGATVRR--ALYEA
KSAVVLTGLAASLL------WGWGAI-L-PTLL--------MPLAGM------------------------AVAAAALH------EAARAVLRA-----S
AQRGAEHARAVLQASPIGLVLLDSGVPVL----------HNERAQFLLDWAGQNHGPN--IAVCEKGCRDA---DAEPVVWV---ADRDRVLALHPVRVE
QAGDE--DRTLVAAVDISVRRRLEDELRHRSERDVLTGLTSRSHFLHLLDRALRA----G-DVGLLVLDLDQFKEVNDTEGHDAGDQCLVAASRRIRAAV
EPDAVAARLGGDEFAVLAPGLDEA-CGQLAKSVLAELEKPWSDLGYDVRMQASIGVAVSSAAAVGTAELLRDADTAMYVAKREGGARARSFRREMGEQAL
ARQRDKLDLRAAIGTDQLVLHYQPIVDLATTAISGAEALVRWERPGRGLLGPGEFIGLAEQTGLIVPLGSSVLTSACTQAAGWRA-AGRELGVTVNVSTR
QLSAPGFLAALAKSLDVSGLQASALTIEVTESVWADE--AAMRALMAVRETGVRVALDDFGTGYSSLSYLHRYPFDVVKIDKSFTWALGDTGRTAGVVRC
IIDLADVLGAVTVAEGIETPEQAEWLRRAGCGFGQGFLFGRPDLPRNLALPQVGR-----
>tr|A0A098GDK5|A0A098GDK5_TATMI Putative regulatory protein (GGDEF and EAL domains) OS=Tatlockia micdadei GN=LMI_1273 PE=4 SV=1
----------------------------------------------------------------------------EKYLSLLRATLESTADGIMMVNGK
GQVV-WNQKFVEMWRIPSHMLESGKEIL-EQLSNPAAYE--NPDWEG-----E-----------DGFERYTQPQ--------RVVGRVY-SFRDL----M
SEDELRI--A-IEASTHGVAII-KNQPIIYVNKAFERITGYTDKQAIGQNLAHLQADQVQKRV----ALAIREQREET-ELESFRRNGELYWCELSVAPV
SDSFNQVRHYVCILNDITQRREMEKQLIRQATHDSLTELPNRVLLMDRVEQAILQAKKK--LLGFLFLDLDRFKLTNDTLGHSVGDKLLQAVSNRLLIAT
NDFDTVARLGGDEFVILLPELTSQQAQQMAQEILHLIEKPFQIDQHSLKVTGSIGISFYPKDGLDYESLMKSADLSMYHAKDSGRNSYRIFDQEMNRRII
NHMQLDNALRDAMKNNEFYLVYQPLIDLKKNHIVGFEALIRWNSHLLGQVSPMEFIGMAEENGLIIDIGKWVIEEACTQAIRWHKE-YKNLSIAVNISGR
QFRQTNLPELINEVLKRTGLAAKFLELELTESLLVDDIDHAVDTMYKLKDMGIKLVIDDFGTGYSSLSYLKQFPVDKLKIDQSFINELVNKENDAAIARA
IINLGHSLNLEVLAEGVETELQKDFILAHGCDYAQGYYFKPPNVPDELKDYLSHFL----
>tr|A0A0A8UU88|A0A0A8UU88_LEGHA Sensory box/GGDEF family protein OS=Legionella hackeliae GN=LHA_2061 PE=4 SV=1
----------------------------------------------------------------------------EKSLSLLRATLESTADGIMMVNGK
GQVV-WNQKFVEMWRIPSYMLESGTEIL-EQLSNPAAYE--NPEWQG-----E-----------DGFERYTQPQ--------RVVGRVY-SFRDM----M
ADDELRI--A-IEASTHGVAII-KTQPIIYVNKAFERITGYSEKQIIGQNIAQIKIDQVQKRV----ELAIREQREET-ELESYRRNGEMYWSELSVAPV
SDSFGKIRHFICIINDITQRREMEKQLVRQATHDSLTELPNRVLLMDRVEQAVLQAKKK--LLAFLFLDLDRFKMTNDTLGHSVGDKLLQAVANRLLIAT
NDYDTVARLGGDEFVILLPELATAQAQQMAQEILHLIEKPFQIDQHSLKVTGSIGISYYPKDGLDYESLMKSADLSMYHAKDSGRNSYRIYEPEMNKRVI
NHMQLDNALHDAMKRNELYLVYQPLIDLKRHRVVGFEALLRWNSHLLGQVSPADFIGMAEENGLIIDIGKWVLEQACTQTLAWHQS-FKDLTIAVNISGR
QFRQSELPEVIREVLAKTGLPAKYLELELTESLLVDDIEHAVETMYQLKDMGMKLVIDDFGTGYSSLSYLKQFPVDKLKIDRSFICELVNKENDAAIARA
IINLGHSLNLEVLAEGVETELQKEFIVEHGCDYAQGYFFKPPATPDALKEFLKKYP----
>tr|A0A078L266|A0A078L266_9GAMM Bacteriophytochrome cph2 OS=Legionella massiliensis GN=cph2_6 PE=4 SV=1
----------------------------------------------------------------------------EKSLSLLRATLESTADGIMMVNGK
GQVV-WNQKFVEMWRIPSHMLEIGTEIL-DQLSNPAAYE--NPEWQG-----N-----------DGFERYTQPQ--------RVVGRVY-SFRDM----M
SEDELRI--A-VEASTHGVAIV-KNQPIIYVNKAFERITGYSEKHALGQNIAHLKTDQVQKRV----NLAIREQREEV-ELECYRRSGEMFWCELSVAPV
NDSFGRVRHYVCIINDITERREMEKQLVRQATHDSLTELPNRVLLMDRVEQAILQAKKK--LLAFLFLDLDRFKMTNDTLGHSIGDKLLQAVSNRLLIAT
NDFDTVARLGGDEFVILLPELSSMQAQQMAQEILHLIEKPFQVDQHSLKITGSIGISYYPKDGTDYESLMKSADLSMYHAKDSGRNNYRVFEQEMNRRII
NRMQLDSALRDALKKHEFYLVYQPLVDLRKNIVVGFEALIRWNSQLLGQVSPVEFIGVAEENGLIIEIGQWVMEEACKQAIIWHEQ-YKGLSMAVNLSGR
QFRQKNLTDVVAEVLKKTGLPPKYLELELTESLLVDDLEHAVDTMYKLKDMGTRLVIDDFGTGYSSLSYLKQFPVDKLKIDRSFICELVNKENDAAIARA
IINLGHSLNLEVLAEGVETELQREFILKHGCDYAQGYYFKPPNIPSELNKFLEEYS----
>tr|A0A078KZI0|A0A078KZI0_9GAMM Bacteriophytochrome cph2 OS=Legionella massiliensis GN=cph2_3 PE=4 SV=1
----------------------------------------------------------------------------EKSLSLLRATLESTADGIMMVNGK
GQVV-WNQKFVEMWRIPSYMLEVGTEIL-EQLINPEAYQ--HPDWEG-----D-----------DGFERFTQPQ--------RVVGRVY-SFRDM----M
SKEELHI--A-IEASTHGVAII-KNQPIIYVNKSFERITGYSEKQLIGQNLTHLTTDQVQKRL----DLAIREQREEV-EVESYRRNGEIYWCEISVAPV
NDSFNKVRHYVCIINDITLRREMEKQLIRQATHDSLTELPNRILLMDRVEQAILLAKKK--ELAFLYLDLDRFKMTNDTLGHSIGDKLLQAVSNRLLIIT
NEFDTVARVGGDEFVVLLPDLNSIQAQQIAEEILHLIEKPFQVDQHNLKITGSIGICYYPKDGPDYETLMKNADVSMYHAKDSGRNTYRVFEKEMNSRVI
NYMQVDSALRDALKKNEFYLVYQPLIDLKRNTIVGFEALLRWNSQLLGQVLPLDFISMAEENGLIIDIGKWVLENACLQAKAWHQE-YKNLTVSVNISGR
QFRQANLPEIIGEALKKANLAAHYLELEFTESLLIEDVEHTINTIYKLKDMGVKLVIDDFGTGYSSLSYLKQFPVDKLKIDGSFINELVNKENDAAIAKA
IIDLGHSLNLEVLAEGVETEMQRDFVLNHGCDYAQGYYFKPPNVPEELKEFLKAYS----
>tr|D3HM00|D3HM00_LEGLN Uncharacterized protein OS=Legionella longbeachae serogroup 1 (strain NSW150) GN=LLO_3035 PE=4 SV=1
----------------------------------------------------------------------------EKSLSLLRATLESTADGIMMVNGQ
GQVV-WNQKFVEMWRIPSHMLESGTEIL-QQLSNPEAYE--NPEWQG-----E-----------DGFERFTKPQ--------RIVGRVY-SFRDL----L
EEDELRI--A-IEASTLGVAII-KNMPIIYVNKAFERITGYSERQILGQNLSFLQVEHVHKRL----NFAIKELREET-EIECFKRNGEVFWAEVSVAPV
RDSFDNVKHYICILNDVTQRREMEQQLIQQATHDSLTELPNRVLLIDRVDQAILQAKKK--ILAFLFLDLDHFKMTNDTLGHSLGDRLLQAVSNRLLIAT
NDFDTVCRLGGDEFVILLHDIATQQAEQKAEEILKSIANPIRIDQHNLKITGSIGISYYPKDGDDYESLMKNADLSMYHAKDSGRNTYRSYDKEMNMRII
NRMQLDNALRDSLKRNEFHLVYQPLINLATNKIIGFEALLRWHSHILGDVSPTEFISMAEENGLILEIGLWALREACKQLVSWHQQ-YSNLTMAVNISGR
QFRQSHLSEIIEKTLLETGLSAKYLELELTESLLVDNVKHAVETMYELKDMGTKLVIDDFGTGYSSLSYLKQFPVDRLKIDRSFINELVNRENDAAITRA
IINLGHSLNLEVLAEGVETELQLEFITNHGCDYAQGYYFTTPQKAEELKNFIIQHI----
>tr|G9ERZ4|G9ERZ4_9GAMM Putative uncharacterized protein OS=Legionella drancourtii LLAP12 GN=LDG_8066 PE=4 SV=1
----------------------------------------------------------------------------EKSLSLLRATLESTGDGIMMVNGH
GQVV-WNQKFVEMWRIPSYMLESGTEIL-EQLTNPETYK--NPEWQG-----E-----------DGFERFTQPQ--------RIIGRVY-SFRDR----M
DEDELRI--A-IEASIHGVAII-KNFPIIYVNKAFERITGYTEKQILGQNLIALHTEDVHKRI----TLAIKEQREEI-EVEGYRRNDESYWCEISVAPV
SDSSANVKHYVCLINDITQRREMEKQLIQQATHDSLTDLPNRVLLIDRVDQAILQARKK--ILAFLFLDLDRFKMINDTLGHSIGDKLLQAVSNRLLIAT
NDFDTVCRLGGDEFVILLQDIGSKQAQQIADKILRTISKPFPIDQHDLQITGSIGISYFPKDGTDYESLMKSADLSMYHAKDSGRATYRTYDKEMNTRII
NHMQLDNALRDSLKKDEFHLVYQPLINLAENKIVGFEALLRWHSHILGTVPPSDFIGMAEENGLILEIGMWVLKEACCQLVRWHKL-YSKLTMAVNLSSR
QLRQSHLPELIKKTLFETGLSPNYLELELTESLLVDNVKHSIETLYALKDMGAKLVIDDFGTGYSSLSYLKQFPVDKLKIDRSFVSELINKENDAAIARA
IINLGHSLNLDVLAEGVETELQCQFMLKHGCDYAQGYYFTPPLKANELNEFLIKYT----
>tr|A0A098G335|A0A098G335_9GAMM Diguanylate kinase OS=Legionella fallonii LLAP-10 GN=LFA_0961 PE=4 SV=1
----------------------------------------------------------------------------EKSLSILRATLESTADGIMMVNGQ
GAVV-WNQKFVEMWRIPSYMMESGKEIL-EQLTDPQSYQ--NPEWQG-----E-----------DGYERFTQPQ--------RVVGRVY-SFRDR----M
ALDELRI--A-IEASTHGIAII-KENKVIYVNKAFERTTGYPEMQALGKSLHTLDVDEVNKRI----QLAIRELREET-EMENIRRNGEVFWCEISVAPV
KDLLGHVKHYVCILNDITQRRDMENQLIMQATYDSLTNLPNRVLLMDRVEQAILQAKKK--ILAFLFLDLDRFKMTNDTLGHNMGDKLLQFIANRLLIAT
DDFDTVARLGGDEFVILLSNLDEKQAETMAQDLLHAIARPIQIDQHSLKITASLGISFYPRDGQDYESLMKSADLSMYHAKDNGRNTYRVFEPEMNRRVI
NHMQLDTALRDALKNHELYLVYQPLIDLKRSKVVGFEALLRWNSKNLGMVSPVNFIPMAEENGLILDIGEWVLREACTQLKSWQKQ-LKNLSVAVNISGR
QFRQTNLPDLVAEILKSTGLQSKHLELELTESLLIEDIEHVVETMYALKDMGIKLVIDDFGTGYSSLSYLKQFPVDKLKIDRSFISEMATNQNDAAIAKA
IINLGHSLNIEVLAEGIENEFQRDFITAHGCDFAQGYYYKAPETADKIYEFIRGLH----
>tr|Q5WY17|Q5WY17_LEGPL Legionella pneumophila str. Lens complete genome OS=Legionella pneumophila (strain Lens) GN=lpl0922 PE=4 SV=1
----------------------------------------------------------------------------EKSISLLRATLESTADGIMMVNGH
GAVV-WNQKFVEMWRIPSYMMESGKEIL-EQLIDPQAYQ--NPEWQG-----E-----------DGYERFTQPQ--------RVVGRVY-SFRDR----M
ALDELRI--A-IEASTHGVVII-KENKVIYVNRAFERITGYGEQYALGKGLFTLNLEEVHKRI----ELAIRESKEET-EMESIKRNGEFYWCEISVAPV
KDSFGYVKHYICILNDVTQRRDMEDQLLQQATYDSLTNLPNRVLLMDRVEQAILQARKN--ILAFLFLDLDRFKLTNDTLGHSMGDKLLQAIANRLLIVT
EDFDTVARLGGDEFVILLTDIDNLEAETIAQNILKIIEKPIQIDQHSLKITGSLGISFYPRDGDDYESLMKSADLSMYHAKDTGRNNYRVYEPEMNRRVI
NHMQLDNALRDALKNDELFLVYQPLIDLKQSRVVGFEALMRWHSKILGLVSPADFIPMAEENGMILEMGEWAMKQACMQVKEWHKA-FKNLSIAVNLSGR
QFRQKNLPEVVSRVLKSSGLQSRFLELELTESLLIEDIDHVVDTMYALKDMGTKLVIDDFGTGYSSLSYLKQFPVDKLKIDRSFITEMVSNQNDAAIAKA
IINLGHSLNLQVLAEGVENEFQRDFITSHGCDYAQGYFFKAPDTPENILEFLKSLS----
>tr|U2FV44|U2FV44_9GAMM Sensor diguanylate cyclase-phosphodiesterase PAS domain-containing protein OS=Salinisphaera shabanensis E1L3A GN=SSPSH_001255 P
-------------------------------------------------------------------------------MSEYHHLAENSPAALVLVRLN
GTII-ANNAACRLLGLYRQQMEQLTV------------------WLA-----RPIERT----RSSGFSAQLSSR--------VFHGRVAIVLRTD----A
DVAQVAL-HA-------------DNTRIRALNPAYTRITGYDEAAALGQSLELGRRGADWDGL----IEAMSPGERWT-EVQNRRRNGELYPAYVKITAL
APSEEAAAQFVVVFRDLSADKAYEARIEYLAHYDTLTGLANRTLIEKRAELARIAVA-RD-HLALLFLDLDGFKAVNDSLGHATGDELLRHVADRLRSAV
SKTDIVARQGGDEFVILLDSISKEDAAYVAARIQETLRVPLTLNDQTVFTTASIGISCYPDDSQDLTTLLRNADMAMYRAKRQGHGRYVFYRPEMDANAH
WMLQLRNNLHRALDRDELHVYYQPFVDVDSGTVTGIEALLRWQNDELGMVSPVDFIPIAEETGLIIEIGQWVLRAACRELQRLHAR-YDHLRVAVNLSAR
QFRQTDLVAQIADVLAETGLASRYLELEITETVLMEQAGATLDTLHGLHELGVAVALDDFGTGYSSLSYLRRFPITYLKVDKSFVDGIPGEKGDLTITRT
IVAMARSLGIRVTAEGVETAAQGKWLRHWNCEEAQGYLYSLPLAADDLEWLLCNHD----
>tr|B1XYG5|B1XYG5_LEPCP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) GN=L
------------------------------------------------------GSPAWLLVLVDQQNAQQLADEVSRLASELGATLESSHEAILVTDLN
GQVRSHNAAFATLWRLGDDDDSGADDAQSRAMADPLGYETLDQRQAAATEPVGARCATDRLLLADGR-TFERRL-VPQY-GRGQAVGWVQVWRDLSLELA
QQARLQVAAQVFEASLDALIVTDAQHRIVATNPVTQALTGLDAGALQGRTLASLLADTMQAQVISNALAELPRLGHWQGELTLGSPLGA-LPVQAHLI--
-DMAGLAGGCIVVLRDLRERLAQERRLRELALTDALTGLPNRLQLDQKVRDEVQRCQKATGGFALLLFGLDRFTHINDSLGHGCGDRVLVEVARRLSANV
RLGDAVARLGGDSFVMMLKDSDAAAAEPIARRLLEQLAEPLALDGLRLTIKASVGIALFPADGADADNLLKNADSAMHRVKERQGGALRFYQPQMNDDLL
ARMQLDHAMRQALARGEFRLHYQPQLDLHSGAVIGAEGLCRWRDAERGEVSPGRFIPVAEETGFIAELGHWVLCEAVAQAASWRRQGLR-MPVSVNVSAL
QFQAAGFVDSVAGVLAQAQLPAELLELELTESILLGDIDEIVGQLQRLADLGVKLAIDDFGTGYSSLRYLKRLPIHRLKIDRDFIRRLPDDPSDAAITRT
IVDLGRALHLQVIAEGVETPEQHACLAAMGCHEYQGFLFAPALPATQFEALLRQSLRR--
>tr|I0HXN4|I0HXN4_RUBGI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rubrivivax gelatinosus (strain NBRC 100245 / IL144) GN=RGE_4435
------------------------------------------------------VPTHALVTLRDRSGEQRAEDEREAVVAELQATLESTGDGILVTDLE
GRVRAFNRRFGQIWAVPEELLEARDSIWRRRTLDAEGYDRLAALR-----AAPLLSSTERLELVEGQ-TVQRVT-RPLW-GRAGPQGRVYSFSDQTELVK
----------------------------------------------------------------------------------------------------
----------------------VRALSETLSSHDALTRLPNRTLLAEKVAEAALRWRREQQPFALLVVDLDHFRRVNDSFGQQVANRVLCEVAERIGAAL
RSQDVLARIGGDNFAALLQDADQASAQKAVLRVLKVNTQPFDADGTPFSLTCSVGIALCPQDGQALDDLVRQAEAAVRRAKAAGRAGYRFAEPVPGGDAH
SHVRMVHAMREALKAGHFRLHYQPQIRFRDGAVCGAEALLRWRDPQLGEIAPAAFIPVAEDSGFIVTLGSWVLSQAVRQAALWHEAGRS-LTVAINVSAL
QFRQPDFVSQVADVLAVSGLPAHLLELELTESILVEKADEALERLQALDRLGVQLALDDFGTGYSCLGALKRMPIGRLKIDRSFVAGLPDDDTDVGLVRA
ISQLAQALGKRVVAEGVENEAQRRFLAELGCESFQGFLYAPAMDPASFERHLPPPRPR--
>tr|W0SJI2|W0SJI2_9RHOO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_03033 PE=4 SV=1
------------------------------------------------------PRDGTLWMIEDIAEDRLMIDALERSTRELSAILDTASAGIAVVRNR
-IFVRCNRRFEEIFDLPTGSLLGQSSLSEEFQTGEQVYSEAAGR---------VHRREQLFVRRGSQ-TWLRVS-GSAF-DPGNPAGSVWLTEDFTATRE
TEERARQAFLIFDNAAVGILFA-RDRMVQRCNRRLAEIFGYQQDELAGRSTRVFYLNEEDYQNGAAVLSVVMAGGTYIGENRVRHKDGHAFWIDMTWIFE
DVTERHASANTQLQEEVFERMQAEQRIWHIAHHDSLTGLPNRTLLHDRLEQALAQALRGRHRVAVMFLDLDRFKNVNDTLGHAIGDELLKHVASRLTSVV
RAVDTVSRLGGDEFVIVLHEVSSPDAVQVAEKILGALGAAASIDGHQLHATPSIGISIFPDDGDEVFGLMKSADTAMYHAKAVGRNNFQFFARAMNEQAE
HFFTLENRLRQAIDGGQLLLHYQPLIDWPRRTVCGMEALVRWSDPERGLIEPGEFIPIAEETGLIVPVGEWVLAEALRQNREWQQEGRP-LPISVNLSPR
QFRQKDLVETLRRILLETGQPARLLELEITETTLMQDIDETRDKLEEIAAMGVRLAIDDFGTGYSSLSYLKRFPVHKLKVDQGFVRDLTVDPEDAAIVTA
IIGLARSLGLDTLAEGVETAEQLDILRGLGCEKFQGYLFSRPLPPTLADGIFSPLPNQ--
>tr|H0C1H6|H0C1H6_9BURK Diguanylate cyclase OS=Acidovorax sp. NO-1 GN=KYG_17607 PE=4 SV=1
-------------------------------------------------------LSVFMVTMLDRSVQESTERELETLLSELRATLDSAADGMLVCNLE
GTVRAFNQRLAQLWNIPNELLVERDDVHVAQTQDARAYVEMAALV-----REPMLESTDIVTLRDGM-VLEMRT-VPQF-IQGRPVGRVYSYRDITRQTE
IHASLRLAARVFESSLDAIFIADSQHRVLRMNPGCERLVGPSAKAFEGCVAASLFGGG-SD-FMEQVLQGWAHEGFWEGELWLPRDNGTYCAVQLSWVAL
RDDEGRLVQSIGFMRDLTLQHAAQKRIEELAYSDVLTGLPNRLLLSQRVDTAIQGARQSDTGFAILFLDLDRFKIINDSLGHPFGDRVLQLVAERLQACL
RQTDMLCRLGGDEFVIYLHGGDAVVAESVARRILDDMLKPFTLDSMGFSIQCSIGMALYPQDGATLDDLIKQADTAMYRVKERGRGSYGFYQPQMNANLL
SRMQMEHAMRQALGKGLMAVHYQPQVHMATGRITGAEALIRWTDPEFGSVSPAHFIPLAEESGYIVTLGAWVMEQAVREAAMWMHGGTP-IMISVNVSAL
EFRQPDFVERLTRLLAVHQLPPTLLELELTETILLQDAQEMEQRLLALADLGIGLAIDDFGTGYSSLAYLKKLPIHKLKIDQSFVRGLPDDEGDRAIVSA
IISMGRAMHIEVVAEGVETETQQAVLLQMQCDHYQGFLCAPGLPSEEFRVMLGKPLPL--
>tr|K0HV05|K0HV05_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. KKS102 GN=C380_15520 PE=4 SV=1
-------------------------------------------------------STVLLLTMLDRSLQETTERELETLLSELRATLDSAADGMLVCGLD
RRVRAFNQRLAQLWNLPRQLLVERDDVFADQVSDPRFYAELAAID-----REPMEESTDIVELRNGV-VLEMRT-VPQF-SQGRAVGRVYSFRDITRQTE
TQASLRLAARVFESSLDAIFIADSQHRIMRMNPGCERLVGPTAKGFEGCVAASLFGGG-SD-FMEQVLQGWAKDGFWEGELWLPRDNGAYCAVQLSWVAL
RDDEGRLVQSIGFMRDLTLQHAAQKRIEELAYSDALTGLPNRLLLSQRVDTAIQGARQSDTGFAILFLDMDRFKIINDSLGHPFGDRVLQLVAERLQTCL
RQTDMLCRLGGDEFVIYLHGGDASVAESVARRILDDMLKPFMLDSMGFSIQCSIGIALYPQDGATLDDLIKQSDTAMYRVKERGRGSYGFYQPQMNANLL
ARMQMEHAMRQALGLQRMAVHYQPQVNMATGRITGAEALLRWTDPEFGAVSPAVFIPLAEESGYIVTLGAWVMEQAVREAALWMHSGSP-IMISVNVSAL
EFRQPDFVDRITRLLAVHQLPPTLLELELTETILLQDAQEMEQRLRVLAELGIGLAIDDFGTGYSSLAYLKKLPIHKLKIDQSFVRGLPDDDGDRAIVSA
IISMGRAMHIEVVAEGVETETQQAVLQQMQCEHYQGFLCAPGLPADQFRALLSKPLPL--
>tr|J0K903|J0K903_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_05389 PE=4 SV=1
--------------------------------------------------------TAFLVTMVDRSHQQATERELETLLAELRATLDSAADGMLVCSLD
GRVRAFNQRLAQLWNVPAPLLVRRDDLHADQVADVPTYVELAAIV-----AEPMQESIDILGLRNGM-SLERRS-VPQF-SQGRAVGRVYSFRDITRQHE
VQASLRLAARVFESSMDAIFIADSHHRLMRMNPGCERLVGKTARAFEGAAAASLFGGG-PD-FMAQVEAGWAREGFWEGELWLPRENDAYCAVQLSWVAL
RDDEDRLVQSIGFMRDLTLQHAAQKRIEELAYSDVLTGLPNRLLLSQRVDTAIQGARQSDTGFAILFLDLDRFKIINDSLGHPFGDRVLQLVAERLQTCL
RQTDMLCRLGGDEFVIYLHGGDSVVAESVARRILDEMLRPFTLDSMGFSIQCSIGMALYPQDGSSLDELIKQADTAMYQVKERGRGSYGFYQPQMNANLL
SRMKLEHAMRQALGEQRMAVHYQPQVSMETGAITGAEALIRWTDPEFGPVSPGMFIPLAEESGYIVTLGAWVMEQAVREAAAWIHGGHP-IVVSVNVSAL
EFRQPDFVERLTRLLAVHQLPPTLLELELTETILLQDATEMEQRLHELARLGVSLAIDDFGTGYSSLAYLKKLPIHKLKIDQSFVRGLPDDDGDRAIVSA
IISMGHAMRIEVVAEGVETEVQRAVLAQMQCDHYQGFLRAPGLPAEDFRRLLGRPVAA--
>tr|C5T0G3|C5T0G3_ACIDE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax delafieldii 2AN GN=AcdelDRAFT_0393 PE=4 SV=1
-------------------------------------------------------HAALLLTMLDRSRQEATEQELETLLCELRATLDSAADGMLVCGLD
GRVRAFNQRLAQIWGIPRDLLVQRNDVHAAQVLDGKGYRDLAALE-----REPLLESTDILELRGGV-TLERRV-VPQL-HQGRPVGRVYSFRDITRQAE
VQASLRLAAQVFDSSLDAIFIADSQHHLMRMNPGCERLVGPSAAAFLGCLAASLFGGG-SD-FMEQVQAGWDREGFWEGELWLPREGGAYCAVHLSWVAL
RDDEGRLIQSIGFMRDLTLQHAAQKRIEELAYSDVLTGLPNRLLLTQRVDTAIQGARATDTGFAILFLDLDRFKIINDSLGHPFGDRVLQLVAERLQACL
RQTDMLCRLGGDEFVIYLHGADAVVAESVARRILDDMLRPFLLDGMGFSIQCSIGMALYPQDGEGLDDLIKQADTAMYRVKERGRGSYGFYQPQMNANLL
MRMRLEHAMRQALGEQRMAVHYQPQVNLVTGRIVGAEALIRWTDPEFGAVPPAQFVPLAEESGYIVTLGAWVMEQSVREAARWMHEGMP-IVVSVNVSAL
EFRQADFVERLTRLLAVHHLPPTLLELELTETILLQDAQEMEQRLRALADLGVHLAIDDFGTGYSSLAYLKKLPIHKLKIDQSFIRGLPEDEGDRAIVGA
IISMGRALHIEVVAEGVETTTQRAVLQQMECQHFQGFLCAPGLPGAEFRQLLGKSVRG--
>tr|A0A0A1VFA2|A0A0A1VFA2_9BURK Diguanylate cyclase OS=Acidovorax sp. MR-S7 GN=AVS7_02008 PE=4 SV=1
---------------------------------------------------------LLLLTMYDRSEQEASERELETLLSELRATLDSAADGVLTCNLH
GEVRAFNQRLAQIWHIPRELLVQRDDIHEAQVLDRDAYRALASIA-----LEPLLETTDVLHLRNGA-TIERCS-VPQL-IKGRPAGRVFSFRDISRQAE
VQAGLRLAARVFESSLDAIFIADEQHAVARINPGCERLLGADAQALVGRPAQSLLCPNDEA-FMARVADGWARRGFWEGELALARQDGSRCAVQLSWVAL
RDDAGAITQSIGFMRDLTSQHAAQRRIEELAYRDVLTGLPNRLLLGQRVMAAIDGVSTRGGGFAILFLDLDRFKIINDSMGHPFGDRVLQLVARRLQDCL
RQSDMLCRLGGDEFVIYLHDADAVVAEAVARRVLDEMASPFMLDELGFSIQCSIGMALYPRDGMTLDDLIKQADTAMYRVKERGRGSYGFYQPQMNAHLL
SRMKMEHAMRQALGQGHMAVHYQPQVGMADGRIVGAEALVRWTAPELGAVSPSVFIPLAEESGYIVTLGAWVMEQAIREAARWRRCGVP-LPVSVNVSAL
EFRQPGFVERVTGLLDECGLPPDQLELELTETILLQDALEMEQLLHALSQLGVRLSIDDFGTGYSSLAYLKKLDIHKLKIDKSFVSGLPGDEGDRAIVRA
IASMGRALRIEVLAEGVETEQQRLALREMDCDCYQGFLCAPALPMADFRALLARQWGA--
>tr|A0A0D7KB00|A0A0D7KB00_9BURK Diguanylate cyclase OS=Acidovorax temperans GN=RP29_11685 PE=4 SV=1
--------------------------------------------------------GALLLTMIDLTAQRSTERELETLLSELRATLDSAADGMLVCAMD
GSIRAFNQRLVNIWRIPAELLTRRDDVHAKQVREAELYSELREIA-----ADPMQESSDILELTEGT-VLERRS-VPQF-SHGLPVGRVYSFRDVTRQAE
TQAHLRLAARVFESSLDAIFIADSQHRILRMNPGCLKLIGSATELHVGQPAVSLFELE-SP-WMTDVKAGWKTSGFWEGELWLPRVGLPPCAVQLSWVVV
YDDGGKVMQSIGFMRDLTAQHNAQKRIKELAYTDVLTGLPNRLLLSQRVETAIADAQEQYGGFAVLFLDLDRFKIINDSLGHPFGDRVLQLVAERLQTCL
RQTDMLCRLGGDEFVIYLHGGNATVAEGVSRRILDEMLRPFTLDDMGFSIQCSIGIALYPHDGLSLDDLIKQADTAMYRIKDRGRGSYGFYQPQMNANLL
SRMKLEHSMRQALGLDRMAVHYQPQVNLETGRITGAEALLRWRDPDLGAVSPAVFIPLAEECGYIVALGAWVMEQAIRQCAGWVELGHP-MVVSVNVSAL
EFRQPDFIDRLTALLATYRLPAHWLELELTESILLQDAHESEQRLRLLGDLGVRLAIDDFGTGYSNLGYLKKLPIQKLKVDQSFVRGLPEDEGDRAIVGA
VISMGHALRIEVVAEGVETLAQKELLQQMGCDQFQGFLCAPGLTPEDLGELVLNPELV--
>tr|F4GB45|F4GB45_ALIDK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K
------------------------------------------------------ADRYLLLTMQDRSEHEASQRELESLLSELRATLDSAADGVLTCNLH
GEIRAFNQRLAQIWQLPRELLLRRDDIHESQVLDAEAYRLLAAIA-----HEPMLETTDILHLRNGM-TVEQRS-VPQL-IQGRPAGRVYSFRDISRQAE
VQAGLRLAARVFESSLDAIFIADERHAVARINPGCEQLLGAAAQGVVGRRVTALFAMAQDD-FMAEVRQGWEQAGFWEGELRLRQEEDAHCCVQLSWVAL
RDDAGAVAQSIGFMRDLSVQHAAQKRIEELAYSDALTGLPNRLPLNKRVAAAIEASRGHGGGFAILFLDLDRFKNVNDSLGHPFGDRVLKLVAERLQGCL
RQSDMLCRLGGDEFVIYLHDADAAIAESVARRVQEEMLRPFMLDEMGFSIQCSIGMSLYPQDGDALDDLIKHADTAMYRVKERGRGSYGFYQPQMNAHLL
SRMKMEHAMRQALNHGHMAVHYQPQVDMATGCIVGAEALVRWTDPEFGVVSPGTFVPLAEESGYIVTLGAWVMEQAVKEAAHWMGCGTP-LVVSVNVSAL
EFRQAGFVERISALLAQYGLPARWLELELTETVLLQDAQEMQQVLDALARLGVGLSIDDFGTGYSSLAYLKKLTIHRLKIDKSFVGGLPGDGGDCAIVQA
IVSMGRALRIGVVAEGVETQAQRQALQGMGCDCYQGFLCAPAMPAADFRVRMAEPATG--
>tr|S2XYR2|S2XYR2_DELAC Uncharacterized protein OS=Delftia acidovorans CCUG 274B GN=HMPREF9701_00255 PE=4 SV=1
-------------------------------------------------------GEVLLVSMLDRREQALHEAEFESLLGELRATLESAADAILVCDPD
GRIRAFNHRFATLWGIPEALLVRRNDIHAGQVRDAESYAQLKLLS-----AQPLMEASDVLDLRDGR-ILERRA-VPQL-RRGLPMGRIFSFRDITAEAQ
TQAGLELAARVFESSLDGIFIADDHMDVARTNPACERLLGGM--PVQGRTVESLFEATEDP-LGDLARIQWHQGGFWEGDLWLRQAGGARCAVRLSWVPL
RNAQGDVVQSIGFMRDLTQQRVAQQRIEQLAYSDALTGLPNRLNLTERVDAAIEAARAGGTVFSILFIDLDRFKIINDSLGHQFGDRVLKLVAQRLSDCM
RPVDILCRLGGDEFVLYLHGCNAELAAAVARRILQEMERPFLLDGLGFSVQCSIGVAQYPADGLTLDELIRQADTAMYRVKERGRGHFSFYQPQMSAGLL
SRMKLEHAMRQALEHGRMAVYFQPQVHIDSDRIVAAEALLRWTDPEFGVVSPGVFIPLAEESGYIVTLGAWVMEQAVQEAARWQKQGMP-IKVSVNVSAL
EFRQSGFVERVTELLRRYGLEPHLLELELTESILLQDAQDMALRVCQIADLGVGMVIDDFGTGYSNLAYLKKLPISKIKIDQSFVRGLPSDEGDQAIVGA
IISLGLALGVEIVAEGVETHEQLTAIHRMQGHYFQGFLCAPGLPREQFGECLQAQRAG--
>tr|F0Q3W7|F0Q3W7_ACIAP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM 20985 / N
--------------------------------------------------------PLLVLGMLDRSEQASIQGELERLLSELRATLDSAADGMLVCDMG
GRVRAFNQRMAWLWNMPEDLLVQRDDVHADQVIDADAYRALLGIA-----QFPEEETLDILHLRTGT-VIERRS-VPQM-SQGRPMGRVYSFRD------
----------------------------------------------------------------------------------------------------
----------------LTLQHAAQKRIEQLAYSDVLTGLPNRLLLSRCVASALETARAQGGGFAILFIDLDRFKIINDSLGHLFGDRVLQLVAQRLQGCL
RQSDMLCRLGGDEFVLHLDAGDESMAESVAHRILEDMRQPFMLDGMGFSIQCSIGIALHPRDGETLDDLIKQADTAMYRVKERGRGSYGFYQPQMNADML
SRMQLEHAMRQALDRGDFAVHYQPQVAMASGRVVGAEALLRWNDPGLGAVSPGVFIPLAEESGYIVTLGAWVLEQAIREAARWMQAGTP-LVVAVNVSAL
EFRQSGFVERLVSLLRSHGLPASLLELELTETILLQDAQEMAQRLAALAELGVGLSIDDFGTGYSSLAYLKKLHIHKLKIDQSFVRGLPDDESDRAIIEA
IVHIGRALRIQVVAEGVETPQQREALQAMQCHYFQGFLVAPGLPAEDFRALVARDAQG--
>tr|A0A076PHY7|A0A076PHY7_COMTE Diguanylate cyclase OS=Comamonas testosteroni TK102 GN=O987_11375 PE=4 SV=1
-------------------------------------------------------PRWLLLSMLDRSEQLRHESELDMLLAELRATLESTADGMLVCDLR
GGIRAFNHRFAELWQLPESLLVQRDDIHEAQTISSESQFTLQEAQ-----NLSAPETSEVLQLLSGR-VLERRS-VPQL-SRGVAIGRIYSYRDITAESS
SATELRLAARVFESSLDGIFIADAAGAIVQINPAGVQLLHGR--SVLGLAAWALFESEGGP-LLELASARWDVGSFWEGNLWLKQSDGQRCAVWLSWVAL
RDGYGRLVQSIGFMRDMTMQRSAQKQIEQLAYSDALTGLPNRLSLSRHVQAAITAARFTQQPFSILFLDLDRFKIINDSLGHDFGDRVLKLVAQRLGGLL
RPADVLCRQGGDEFVLYLHDCTGEGASAVAARILEEMRQPFMLDGLGFSVQCSIGAAQFPTDGLTLDELIRQADIAMYRVKERGRGNFSFYQPQMSAGLL
SRMKLEHAMRQALDKGHMAVHFQPQVHIRTGRIVAAEALLRWTDPELGVISPAAFIPLAEESGYVVALDAWVLEQSVQEAARWLAMGKP-VKVSVNVSAL
EFRQPDFVDRLKRVLEASGLPAQWLELELTESILLQEAQEMALRVHQIAELGVGLVIDDFGTGYSSLAYLKKLPISKIKIDQSFVRGLPHDAGDKAIVGA
IISMGQALGVELVAEGVETQEQCQAIEQLQGDYFQGYLCSPALPAEQFRKRLEQGA----
>tr|Q21V58|Q21V58_RHOFT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T11
------------------------------------------------------GRAVYVVGIRDLRQQRRTEDELESLVAELRATLESTADGILVTDRS
GDIRNYNRHFAAMWDVPEELLLNPNDLHASRVLDAAAYETLRAIA-----ESPLLETTDVLILITGR-LLERVS-RPQF-SRGQATGRVFSFRDITQSVD
AQSRLRLAAKVFESSVDAIFITDPDLTILAVNPVCERLTDTSQAQLLGESAKSLFQDPCDPE--VRVEQVLRDEGFWRGQVWLDRAGRSACAVHLSWVLL
RDEDGAVLHTICFFKDLTEELAAQKRIEQLAYSDALTGLPNKLLLSQRVGFALRMAERHGSQFGVFFLDLDHFKNINDSMGHVFGDRVLVEVAERIKRCL
RDADTLCRLGGDDFVIFVQEIDARGAEMLAQRILDLMAQAFLIEETSFSVGCSIGIALYPADGRSLDELIKCADTAMYLVKERGRGSFRFYQPQMNVDLL
SRMKMDHAMRRAMEQGMFRLHYQPQISLANGQLVGVEALIRWLDGELGNVSPVLFIPLAEESGFIITIGTWVLKEAVRQAVLWQNAGTP-VTVSVNVSAL
QFQQTDFVEIVANVLKDSGLAPYLLELELTETILVRDANETLNRLHALAALGVALSIDDFGTGYSSLAYLKKFPISKLKIDRSFVMGLPDDEGDRAIVSA
TIGMARGLKLKVVAEGVETIAQRDYLAGLNCESFQGFLCSPGLPAEEFERLMASFPRD--
>tr|A0A060NI71|A0A060NI71_9BURK Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Comamonadaceae bacterium A1 GN
------------------------------------------------------GPPLHLVAMQDQTQQHQTEQQLEHLLAELRATLESTADGILVCDLD
GRIRAFNRLFAQLWDLPATLLSQQDDIWVGRVTDADSYGLLGQIQ-----RLPLLECTDVLVLQSGR-VLERIA-RPQY-ARGRPIGRVFAYRDVTERTA
IEAKLRLASKVFESSLDAIFITDPQHWVLVCNPAAERLTGHTHAALAQCDATGLFFSPTRP-WSKDLLHQLQQQGYWEGELWYRRPDQSALALLVSWVVL
RDGAGQPLNTVLFAKDLSEKLAAQQRIEQLAYTDPLTGLPNRLTLTERVGHAIRVAQRSGTGFAVMFLDLDRFKHINDSLGHLFGDKVLIEIASRLQTCL
RQTDTLCRLGGDEFVIHLHEADAAGAEITARRLIEAVVQPVEIEGLYFNLSCSLGIALYPDDGASLDELIRLSDTAMYEVKERGKGHYRFYRPEMNANLL
ARIQLDHALREGLRAQQFVLHYQPRIDLRSGQLRSCEALLRWQHPERGLVLPSEFIGVAEETGFIVTLGDWVLDSAVQQAAAWLHAGTP-CPVAVNVSAL
QFHQTDWVARVARALNAHALPAELLELELTESILIRDADEALERLLALRDLGVRLSLDDFGTGYSSLTYLKRFPLQQLKIDRCFIATMHTDPVDAAIVAA
IIQMGQALQMEVVAEGVELAEQHARLLALGCDQFQGFLCSPAVPPEPFGQFLRQAR----
>tr|W7VVI5|W7VVI5_9BURK Cyclic di-GMP phosphodiesterase Gmr OS=Methylibium sp. T29 GN=gmr_6 PE=4 SV=1
------------------------------------------------------GQAIFVLGLRDQSAQRQAEDELEKLVAELRATLESTAEGILVTDLH
GAIRGCNQLFAQLWDMPVELLTQRDDIWRGHVVDEQRFVELGELD-----RDPLLRASDVLRLRSGR-VLERVV-LPQY-GRGQPIGRVCSFRDITEQLA
SAARLQLAAQVFESSLDAIFVTDGEHRIAAVNASCERITGLGREQLVGLRTEALLHPPGADDWFELVREQLALRGVWEGELWHRRADGSTLPGQVSLVRL
AAEGTDGVRHVGFFKDLTETVAAQKRIEELAFTDALTGLPNRVMLAERLDFALAMSHRHQTPFALLFLDLDRFKQINDSLGHVFGDRVLVEVAERLKTCL
RQIDTVARLGGDEFVMLLNQTDARGAEAIARRVLEVLGQPFTLEGMSFSVTASIGIAMYPNDGESMDDLIKNADAAMYRVKERGRAGFRFYQPQMNVDLL
ARMKLDHSMRLALERGDFRLHYQPQIDIASNAVVGAEALLRWRDPGLGDVSPGEFIPVAEESGFIVALGEWVLREAVRQAALWRAQGRS-MVVSVNVSAL
QFQQADFVDRVATALAEAKLPATWLELELTESILIRDADEALQRLRALDRLGVQLAIDDFGTGYSSLGYLKRFPIRKLKIDRSFIKGLPGDESDAGIAQA
VIQVARALRLRVIAEGVETMAQRDFLQRAGCDEIQGFLFAPALPVAEFEARTATMLDL--
>tr|H8Z8R7|H8Z8R7_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiorhodovibrio sp. 970 GN=Thi970DRAFT_04997 PE=4 SV=
------------------------------------------------------HPSHYFVGLCDQSDRQAAETELEKLVAELRATLESTGDGILVTDLD
GGIRGFNQRFAELWSLPDTLLTERDDVWAGQTQDARAYIAIDDIL-----REPLLELTDIIGLTKGR-VLERVT-LPQF-ARGNPIGRVYSFRDITQRLA
DEQQLKLASGVFGASLDAIMITGPDFLIEAANPACERLTGFATAELIGQSLERILPLVGELG--DTIARALEQDGFWQGETQQQKKDGSAIPCLMSLVRL
ADSDGKPANYIGFAKDLSETVAARQRIEQLAYTDALTGLPNRVQLSERIEFAIGFARREHSSFSVLFIDIDRFKQINDSLGHLFGDQVLIEVARRITGCL
RRVDTTARIGGDEFVLLLHQSDAAGAEKTARRLLEVMSLPFEIEGMKFSLGCSIGVAIYPEDGETLDDLIKNADSAMYHVKERGRGDFGFYQRQMNLDLL
TRVKVEHALREALGQQRIHLAYQPQLDLRGDRVIGAEALLRWTDPEMGVVSPAEFIPIAEESGFIIPLGAWALREVLRQGEQWNARGIR-LTLSVNVSAV
QFHHAGFVDSLVELLKASTLPPSQIELELTESILIQHVDETLERLKALADLGVKLAIDDFGTGYSSLGYLKRFPIHKLKIDQSFVRDIPGDESDAAISKA
VINLAHSLNLRVIAEGVENESQRQFLLAAGCDEYQGYLCSPAVAPEEFARMVERLSSK--
>tr|I3YBM5|I3YBM5_THIV6 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiocystis violascens (strain ATCC 17096 / DSM 198 / 
------------------------------------------------------GLSFYVVGIANQSEQRAVENELEKLVAELRATLESTADGILVTDLD
GAIRGFNQGFAEMWKLPEALLTERDDVWARSVLDPGEYAAIAAIG-----HDPLLEASDVLALRHGT-VLERVT-LPQY-ARGHPIGRVYSFRDITQRLA
DEKRLTLANRVFEASLDAIFVTDPEFRIMAVNPACERMTDCRSAELAGQALTQSLQLWLGDR--RAILDALARDGFWQGEIAQRTKTGLTFPCLVSLVRV
LDAEGAPFHYVGFVKDLSEAVAARQRIEQLAYTDTLTGLPNRFRLTERLEFAINLAQRERTGFALLFIDIDRFKQINDSLGHIFGDRVLIEVAQRITHCL
RQVDTTARLGGDEFVLLLHQASEFGAEQTARRLLEVMTQPFAIDGMKFSLTFSIGIALYPDDGESADDLIKNADSAMYHVKERGRGHFRFYRPQMNVDLL
TRMKLDHAMREALAEQRFRLAYQPQVDLRTGRVIGVEALLRWRDRELGEISPGQFIPIAEETGFIVALGDWVLREAIRQGEQWHLQGIA-LTMSVNVSAV
QFQQTTFIASLAHMLAASRLPPGRLELELTESILIQNVDDTLVRLDALVALGVRLAIDDFGTGYSNLAYLKRFPLHRLKIDRSFVRDLPDDESDAAIATA
VINLARALKLRVIAEGVENDTQRDFLLAAGCDEFQGFLCAPALKPADFLNLAERIGLA--
>tr|A0A060NU62|A0A060NU62_9BURK Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Comamonadaceae bacterium B1 GN
------------------------------------------------------DTTLRLVAIQDLSVQHATQQRLEHLLAELRATLESTADGILVCDLD
GRIRAFNRLFAQLWDLPNTLLTQQNDIWASRVTDPEGYRLLGLLQ-----RSPLLQTTDVLLLQNGR-LLERIT-RPQL-ARGRPIGRIYAFRDITERYA
TESQLKLAAKVFESSLDAILITDPQQRILACNPATLSLTRTQESDLLGTPATSLFFAPSQI-WLEILRQHLEGAGYWQGELWHRRADGAALALQVSWVVL
RDAEGRTLNTVLFAKDLSEKVAAQQRIEQLAYTDALTGLPNRLTLTERVGHAIRLAQRSGLGFAVLFLDLDRFKSINDSLGHLFGDKVLIEIASRLKHCL
RQTDTLCRLGGDEFVVHLHETDAIGAEISAQRLIDAMVRPIEIDEMHFNLSCSLGIALYPDDGDTLDELIRHADTAMYEVKGRGKGHYRFYRPEMNANLL
ARLQLDHALRQGLRAQQFVLHYQPRIDLHNGQMRSCEALLRWQHPERGLVLPGEFIGVAEETGFIVALGDWVLEQAVRQAAAWQDAGTP-CPVAVNLSAL
QFHPGGLVMRVQQLLSTYGLQAHLLELELTESILIEDADEALARMQELRALGVRLSLDDFGTGYSSLGYLKRFPLQQIKIDRSFIATMHSDAVDAAIVTS
IIQLARALKMEVVAEGVELEEQRQHLRELGCDQYQGFLCSRAVPASEFHACWLQPR----
>tr|G2E431|G2E431_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_3044 PE=4 SV=1
------------------------------------------------------GNMFFVVSVSDLDERRAVEGELEKLVAELRATLESSADGILVADLD
GKIRGFNQRFAEAWELPEGLLTERNDVWRDAVLNPTEYAAVEAIE-----NNPLLESTDLLMLRNGQ-VLERVT-LPQY-ARGHPIGRVYSFRNITQRLV
DEKSLKRAARVFEASLDAIFVTDLDLGILTVNPACERMTGLHAGEIVGQSLTRFLSLGSDDQ--HSILDTLDRDGLWQGEIHQHRRDGEGFPCLVSLVRV
LDADGRPFQFVVFVKDLSEAVAARERIEELAYSDALTGLPNRVRLTERIEFAIKMARRGRSGFAVLFLDLDRFKQINDSLGHLFGDRVLIEVAHRIKGCL
RQVDTTARLGGDEFVLLLHQTDVLGAEQTARRLMEVMSRPFEIDGMKFSLALSIGIALYPQDGETLDDLIKNADSAMYHVKERGRGDFRFYQSQMNVGLL
SRMKIDHAMREALEEQRFRLFYQPQIDLYSGRLVGAEALVRWTDPSLGVMAPSDFISIAEETGFIVTLGGWVLREAIRQGELWQIQGID-LTMSVNVSAA
QFHQLNFVESLAQWLTASRLPASRLELELTESILIQNVDETLIRLDALVDLGVRLAIDDFGTGYSSLAYLKRFPIHKLKIDRSFVQDIPDDESDAAISTA
IINLAHSLNLKVIAEGVENDIQRRFLLDAGCDEFQGYLCSPPVDPDSFVQLVGALGLS--
>tr|D3RR74|D3RR74_ALLVD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 1038
------------------------------------------------------GRCLYLACFSNQSERRAVESELEKLVAELRATLESSADGILVTDLD
GAIRSFNQRFAELWRLPAALLTERNDIWVREVLDAEGYAALQAIA-----QNPLLEASDLLTLRQGR-VLERVT-LPQY-ARGRPIGRVYAFRDITQRLH
DEQGLKLAARVFEASLDAIFVTDPEFRIVAVNPAGERMTGLAGAELVGQRLDRSLRLWANET--PDIRAALDRSGHWQGEIEQHHADGSTFPCLVSLMRV
LDTEGLPFHYVGFVKDLSETVEARQRIEQLAFNDALTGLPNRLRLTERLEFSIELARRENTRFAVLFIDIDRFKHINDSLGHVFGDRVLIEVAQRIRQCL
RHVDTIARLGGDEFVLLLHRVESHGAELVARRLLESMAQPFELDGLKFSLSCSIGIALYPEDGETLDDLIKNADSAMYHVKEHGRGDCCFYQRQMNVGLL
ERVRIDHAMREALQQGHFWLAYQPQIDLVSGLVIGAEALVRWNDPDLGELAPGRFIPIAEETGFIVALGGWVLREAIRQGAHWQAQGIR-LSLSVNVSAT
QFHQANFIDLLAQWLDETGLPPGRLELELTESILIQNVEETLRRLENLVALGVRLAIDDFGTGYSSLAYLKRFPIHKLKIDRSFVCDIPHDESDTAIATA
VIGLASVLKLRVIAEGVETDIQRQFLLDAGCHEFQGYLCAPALEPAAFLARIAQIGLA--
>tr|W9VYH6|W9VYH6_9GAMM Diguanylate cyclase OS=Thiorhodococcus sp. AK35 GN=D779_1404 PE=4 SV=1
------------------------------------------------------GAPFYVVCVSNQDERRAVETELEKLVAELRATLESTADGILVTDLD
GAIRGFNQRFAEIWGLPENLLTERQDVWDESVLNRDHYIAVEEIG-----RDPLLEATDILSLRNGQ-VLEWVT-LPQY-ARGHAIGRVHSFRNITQRLS
DEKSLKLASRVFEASLDAIFVTDLEFRILTINPACERMTSVCSAEAAGEPLSRFLQLGRDEL--ASIQRVLSRDGVWQGEIRQRRSDGQGAPCLVSLVRV
LDAQGAPFHYVAFVKDLSEAVEARRRIEQLAYTDALTGLPNRVRLTERIDFAIRLAQRENGSFAILFLDIDRFKHINDSLGHLFGDQVLIEVARRIESCL
RHVDTIARLGGDEFVLLLHQADNHGAEQTARRLLKAMEPPFDVGGMKFSLTLSIGIALYPQDGENLGDLIKNADTAMYHIKERGRGDFRFYQTQMNVDLL
ARMKIDHAMREALVDQRFRLVYQPQVDLRTGRLIGAEALIRWSDEVLGEMLPAQFIPIAEETGFIVSLGAWVLREAIRQGEIWQAEGID-IMMSVNVSAV
QFHQANFVDSLAKSLSSSGLPPNRLELELTESILIQNVEETQLRLDALVDLGVRLAIDDFGTGYSSLAYLKRFPIHKLKIDRSFVQDIPDDESDAAIATA
VINLARSLNLRAIAEGVENETQRRFLLDAGCDEYQGYLCSPPVEPADFVVLVSKLGLS--
>tr|H0Q3M2|H0Q3M2_9RHOO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Azoarcus sp. KH32C GN=AZKH_2454 PE=4 SV=1
------------------------------------------------------ARAVYLVGINDCSEQRRVEDELERIVAELRATIESTADGILVVDLA
RGIRSYNHRFAELWDIPRDLMTRRDDTWEQSVIDPEQYARLDQLT-----DHPLLEDTEVIVLHSGK-VLERVS-LPQY-ARGRPVGRVFSFRDITQSLA
DKSRLQLAAKVFSASLDAILIIDSEQRVVAANAKSLESSGCDEGELIGQRTDSLLFKPEDDN--PEILRRVESDGFWEGELTYRRKDGLSIPGLASFVRA
LDDEGKPPQYVLFFKDLTDKLAAKKRIEELAYSDTLTGLPNRVQLNERIEFALNWSAREQRHFAVLFIDLDRFKQINDSLGHIFGDRVLVEVAKRIKECI
RQCDTAARLGGDEFLLLLQDVDQRGAETTARRILAALTRSFVLDDMTLTVTCSIGVALYPGDGLSADDLIKNADTAMYNAKERGRAGFRFYQRQMNLNLL
ARMKLDQALREAFEHQRFRLKYQPQINLATGSVIGVEALLRWTDPEMGEVPPGRFIPQAEENGLIIRLGDWVLNQAVNQAVAWQKKDID-LIVAVNVSAL
QFQNPDFIRSVSTVLRRSGLPPRQLELELTESILIQDADEALLRLQALAELGVRLSIDDFGTGYSSLTYLKRFPIHKLKIDRSFVQGLPNDESDTAITTA
IISIGRTLKLGVIAEGVETESQREFLAVSGCDQFQGFLCSPAVAPEEIEVLASELGTH--
>tr|H5WQ80|H5WQ80_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Burkholderiales bacterium JOSHI_001 GN=BurJ1DRAFT_451
------------------------------------------------------PPTHYLVVAQDLTEQQRHDNEREELVAELQATLESTADGILVTDLG
GRIRAFNQRLAQLWSLPPELLTQRQDVRQRAAQQPQAFARMAELQ-----QATLQQTVERVVLANGQ-VLELTS-RPQC-SRGQPVGRVWAFRDITALV-
----------------------------------------------------------------------------------------------------
---------------------QADRRIQTLSTTDALTGLPNRGQLALAVQAACDAPEPDAEGFGLLLLDLDRFKHINDSLGPQVGNRVLLEVTDRLRGCL
RQGDSVARLGGDQFGLLLRHADRRGAEAAARRVLDATVQAYTLEGMQFTLTGSIGVALYPDDGASFDSLLRNAESAVLAAKQAGRACFRFHQAQDDTQLL
PRIRLDHAMRQALAAHRFRLHYQPQVDLSTGRVVGAEALIRWRDPELGEVSPGQFIPVAEDTGFIVAIGDWVLTQAVAQAAHWRTSGVH-MPVAVNVSAL
QFQQADFVDRVAAVLAAEGLPGHLLELELTESILVRDADEALQRLNALSRLGVHLSIDDFGTGYSSLSYLKRFPIERLKIDRSFVRGLPADDSDVGIVRA
IVQMARALNLDVVAEGVETEPQRRFLMDAGCQMFQGFLFAPALDAASFEQRARASVAN--
>tr|F3K3J0|F3K3J0_PSEAJ Sensory box/GGDEF domain/EAL domain-containing protein OS=Pseudomonas amygdali pv. tabaci str. ATCC 11528 GN=PSYTB_18739 PE=4 S
------------------------------------------------------STPAVLVIVRDITQRKQAQQQLQLSEEKFAKAFHASPDGLAITRQD
GMLLEVNEGFCRITGYSEAYCLEHSTLWDLGDGSVRDFRALRNVD-------------------SIK-LCELSS-HPIV-IAGDD-CLLTIARDITESRQ
MQEKLHLAATVFESTAEGVLITDTNQRINAVNRAFTEITGYSESEAIGQTPRLLASGQHD--FYASMWHQLAADGHWQGEISNRRKNGELYPSWLTINAV
RNKANLTTHFVAVFADISSLKHAQARLDYQAHHDPLTGLPNRTLFESRLLSALLHSEESGSLGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAHRLKETL
RDVDTVARLGGDEFIVLLPGLLQPDAQAIANKLLACFNTPFEAGEHELYISPSIGSCVFPTDGTDVATLVKNADAAMYRSKAKGRNRVESYTCDLTTQAS
ERIALEQELRRALDRNQLSLAYQPKISLLTHTLIGAEALIRWNHPTFGDVPPEHFIPLAEENGMILQIGEWVLEQACQQMGKWHKTCQP-FPVSVNLAGA
QLRQTNLVEHIEQLLADNGLEPGCLQLEITENFIMSQTQEALAVLHKLKKLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFVRGLPEDTHDAAIVRA
IIALGRSMQLTVIAEGVENSEQQQFLTREGCEQIQGYIISLPLQPEEFSERFLLMNLS--
>tr|B8G4E9|B8G4E9_CHLAD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Chloroflexus aggregans (strain MD-66 / DSM 9485) GN=Cagg_0617 P
------------------------------------------------------GSPAMLAVLHDITERKQAEQLLIETQQLLHSALDALPSAIAILDRY
GRVLAANVRWLQLGPLLGVDT---FDVACQLGAQERYEN-VAAV--------------------STR-RWLSVR-AVRF-GAGSRVRVVIVLEDVSARHQ
ADQIALVRRRVLELIAR-------QYDLRTIARELLQLIGEQMPAIRSAGVFVSYHHHDDQPWAEQILTMSPYPRQRIAELPL----DSPVGVNRAWIAV
VRTNRDEKQAIDQIEIALEQHTTLHKLAYQAHHDALTGLPNRLLFEDRLQQAIDLARRNNSLVAVLFIDLDRFKHVNDTLGHAIGDLLLIQVARRFELCL
RATDTLARHGGDEFLLVLPEITSPHVATVARRLHEALDRPFFINGHEIFVSASIGASLYPIDGSDVVSLQRAADIAMYRAKHTLRNSFQFFDAAITNASL
EQLQIETLLRRAIERNELLLYYQPKVD-RSGNLTSFEALLRWNSAELGMVSPVRFIPVAEETGLIIPIGIWVLTELARQVREWQRQGLP-LPVAANVSAL
QFAHVDFVQQVADILAQAALPAGWLELELTETMLMGQIEDLRRQLTELRQLGVTLAIDDFGTGYSSLSYLHLLPISILKIDRSFIMRLDQATVERSITNA
IIALGHHLGMQVVAEGVETEGQFQILLSAGCDLFQGYYIERPLPPDETVAWLRRKV----
>tr|E1IHM4|E1IHM4_9CHLR Diguanylate cyclase OS=Oscillochloris trichoides DG-6 GN=OSCT_2825 PE=4 SV=1
------------------------------------------------------GDPAFLAILNDITERHRDEQLLIESQQFLRSTLDALSAHIAIIDGI
GMIVAVNRAWQEFARNAGFDP---YRVHCDTVIHARYYLEPCNL--------------------KRQ-LWFALR-ITRF-GDGEHVRVVVAHEDISNRKQ
SEILSNERRQVLELVAR-------SQKLEVVGQQILAMIRKHYPALAELPVQHLARPEDVLEWAHTRATDRMRHGQVEHCLP-----DDVCWLRDCWVTP
IRAHTGDAQVIELAEIALEQQEHTRQLAYQAKHDALTGLPNRLLFEENLRRAIDGARHSERMIAVLFIDLDRFKQINDTLGHTVGDTLLIQLARRFESCV
RGSDTLARRGGDEFMLVLTDIVNAQVVKVAHRLMELLQPPFHIAGHELFISASIGASIYPTDGEDPDSLQRRADAAMYRAKH-LRNNFQFFDPTTNQTTL
ERLRLENYLRRALERNELDLYYQPKVN-RQGQIVAVEALLRWKHPDLGIIAPSRFVPMAEELGLIIPIGTWCMARAFSQICQWQRPGRP-ISVAMNVSII
QFSQPGFIETVRTVLDETGLDPSLCIIELTESMLIGDQASVTQRLNDLRALGLKLAIDDFGTGYSSLGYLRRLPISILKIDRTFVSDIGTDDSGRAIINS
IINLAHHLGMQVVAEGVETQLQRDFLHSVGCDMIQGFFYTEPLPPSLFEYLLDSPRLP--
>tr|D3F222|D3F222_CONWI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937
----------------------------------------------------------------------------QHAQEQFRTAFEDAPIGIALFTVD
GRFTEVNRAFCEMVGAERGQIVGIS---VLDHVAPDRPD-SLAAFRAVAGERTTFHAEQRLRRADGREVWCALRASLVRDGAGEPLHFIVQIEDVSARRR
AAEALAEAELAFEGAPIGIALADLDGRFLRVNDALCEITGYTEAELLAANVLLGHSDAAD-AEAEHVDRLMRGIRSYRLERRIVHATGRSVWVSLSVSLV
RDSSGVPRYCIKQLEDISDRKRFEGQLAYLADHDALTGLYNRRAFQRELEQRTS---EDGRGGAVVVIDLDHFKDINDTLGHAAGDEVIVRVARLLAKRL
RKTDVLGRLGGDEFATLLSGVSREEAEAVIAELLRVVRQSVVEGGHPIGLTASAGIALFEGDTLSGEELLVSADIAMYDAKEAGRDRHAISVETEQRQMT
ERMAWSQRMRDALEHDGFVLFQQPVVDLRTGLPKCHELLLRMRGDDGELIPPAAFLPIAERSGLIAEIDRWVTRRAIATIAAQEAAG-RPLRLAVNLSGA
SVSDPGLLEIIEGDLAAMAPPPGSLVFEVTETAAIVNLDRARAFAATLAELGCELALDDFGAGFGSFYYLKRLPFDYLKIDGDFIRQLTSSHEDQLVVRA
IVEIARGLGKRTVAEFVGDEATLELLRELRVDDGQGFHLGRPAPLEDLIAAQNA------
>tr|Q67NQ9|Q67NQ9_SYMTH Putative uncharacterized protein OS=Symbiobacterium thermophilum (strain T / IAM 14863) GN=STH1699 PE=4 SV=1
----------------------------------------------------------------------------ARSEARLAGMLEITPAATVAVDAD
QRIVLFNDMAEQVFGYTREEVLGRP---LDVLLPPTAAQ-HVTRFGLPVRRRMAERQELTARRKSG-ELF-PAQIAIARVAMDDETLFLAVVQDLTERKE
TERRLKESELAFEHAPIGVALLDAGGAILEVNRALCAMLGYAPAELAGRPLDLAHPGAFP-DPA-HL------SAGPAPEVALRHRDGRTIWAQLSCAAL
NGWQSD-TAFILQLQDITDRKRYEEELVRLAMVDSLTDLANRRRFQQELEEAVTEAERTGRSGALVFIDLDMFKHINDTLGHPAGDEVLRQVATILRSAI
RPGDTAARLGGDEFALVLRNADGARAAQVADRLLTAIRARFGGAEAPVSLTASMGVVLFPEHGRSVRELMNRADMALLEAKEGGRDSWAPFTPEGRWQMQ
AQLLWRQRISRALEEDRFVLHYQPILDLRRNAVTRHEALLRMVGDGGELIFPGEFMAVAERFDLIQQVDRWVLERAVRELAELQRAG-RRTVLEVNLSGR
TLMDPVLPAVIRRGLTLRDVDPASLVLEITETAAISDVDQAERFIGEMKALGCRLALDDVGAGFASLYFLKRLPVDYIKIDGAFIRNLPHDTADQHLVRA
LASVCRELGKQTVAEFVDSPKTLQVVREYGIDYAQGYLIGRPGPGVYNTEEPCP------
>tr|W6M137|W6M137_9GAMM Uncharacterized protein OS=Candidatus Contendobacter odensis Run_B_J11 GN=BN874_950001 PE=4 SV=1
----------------------------------------------------------------------------RASEQRFRMLTDQLPVGVFLSNIQ
GECRYVNDRWRQWVGLTADQAAGSM---WLQ-----AVP-MMQAWQQVE-QAGEFAANHRLQSSSGRVTWLSTCAIPLQDRAGRVSGYLGASTDIADLKR
TEETLRASESYFELPLIGIALTGPDKRWWEVNDRLCEMLGYRRSQLLRLSWEITHPDDLA-AEIGQFERVMSR-ESYSLDKRLLRQDGTPIYVSVSSRCV
RRSNGVAEYFVTVVQDITERRQSEERIQHLAQYDALTGLPNRALLDDRLRQAVLRAGRDHRMVGVLLVDLDHFKRINETLGHAAGDRLLRDVVGRLQQCV
RQCDTISRQGGDEFAVLLPELGASDDARLAERMLEAVAQPYRLDDQELLASCSIGISLYPRDGS-AENLLKNADIALYRAKDMGRNNYQFYLSGATMIAR
ERLNLETHLRHAVGKQELELYYQPKWDFHTGAITGSEALIRWNHSQLGLLSPIRFIPIAEDSGLILQLGEWVLRTAVREIGDLHRDGFAGLLVAVNLSGR
QFRQDDLAEMVRGLLEETGFDPACLELELTESILMHHTEDNIATLKSFKGMGARLAIDDFGTGYSSLSYLQRFPVDVLKIDRAFVKDLPGDASSAAIVDA
IVTLAHGLGLEVVAEGVETAEQRDFLHAHNCDIGQGFLFGRPMPLTEFKQLLAR------
>tr|A0A0D8FUD9|A0A0D8FUD9_9ACTN Phytochrome-like protein cph2 OS=Ferrimicrobium acidiphilum DSM 19497 GN=cph25 PE=4 SV=1
----------------------------------------------------------------------------FRSQQRSSIVFENSVAAICITDTE
GNILEVNRSYCELVGLTKETITGQN---ITDLADPHRVH-RLIAGE-----VQSVNFTTRCLHKDGHSIWVDAFYSLVRDRGGVPVYIIASFYDITARRA
SLEALDNSESAFDASPIGVALISIDGRFLQVNSALCQMVGRNASEVIELGVGLTHPSDRD-LTN----QLLKADDVIQVTKRYMHADGHILYVQVTRSLI
IGSDIDERYFISQFRDITDERARSAQLTHQALHDPLTGLANRALFEDRLPQVNARSERLGGSSAVLLLDLDDFKVVNDTAGHHIGDQMLVELSRRLESVT
RSSDTLCRYAGDEFIYLAEGLKSPMEEQVADRLLSVIDEPFHIDGRDFAQHASIGVAVYGANGED-AKIIECADIALYEAKRLGKGTYVVFTPEMNEKTS
TRFQLIQELKHASLSNEFSMSYQAILDLDTESIAGFEASLRWVHPQRGLMLPDAFIPLAEQSDLVLELGAFALHEAISKALSWEIKGAQAPYVMINLTTR
QFHDPNLVTMVDKALAASGIAPTRLILEFTEETALDDISTTVEVLENLKRLDVRTALRDFGAGYSSLSYLAFLQPSIVKVDQSITQSIH----DTAVLET
IVFLSHRLNLSVLAQGIETIDQLASLRQLGCDLGQGSLIAHVLP----------------
>tr|A0A0D8FU25|A0A0D8FU25_9ACTN Cyclic di-GMP phosphodiesterase Gmr OS=Ferrimicrobium acidiphilum DSM 19497 GN=gmr7 PE=4 SV=1
----------------------------------------------------------------------------PEEEQRFRIAFEDTMVAMAVVGLD
GHLLRVNRSLSTMLGYSPNELIGTN---FLDYTHPDRQN-ELAIGK-----ADQLSYVKRLIDRSGRTITAEVSRSLAKDNRGVTIYIVASLRDLTAERT
AETRIVESELAFEDNMAGMVLHDRQGNFVDANEAFCTMVGYSVKELSEHTTPFLHPDDNE-LATPQHRRLLSGASSSRIVTRYLHKNGDVIHVEVARSVA
RDEHGEPIFFVSSVRDITGERSLTEQLSHQATHDSLTGLPNRQFLKDRVTQAHDKLELSGGYNALLLLDIDDFKGVNDTFGHYTGDQLLVGLARRLEAVT
RASDTLSRFAGDEFVYLAEGLASSADEALARRLLSVLDTPFVLDQSTIQRSATVGTVVWDITSKGYDELIQAADTAMYEAKRQGKARNVLYTPDMSERAS
NSFKLAQELGLAVTNNELAMHYQPLVELSSGRIVGFESLMRWHHPTLGTVSPEIFIPLAEQNNLILKLDSFAMNRASTVAASWEAGTPAPPYVTINLSAR
HFHDPTLLPLLEQTLATTNLAPERLVLEITESVALQDIDSAIRVINHIKHLGMTLALDDFGTGYSSLSYLAKLEPNVIKIDRSFVSPASKSNYAQRSVEA
IVSLCCVLGITVLAEGIETSVQLKELLHLGCDLGQGFLFSHAIPADQIQPAEAL------
>tr|A0A0D8FRZ0|A0A0D8FRZ0_9ACTN Cyclic di-GMP phosphodiesterase Gmr OS=Ferrimicrobium acidiphilum DSM 19497 GN=gmr6 PE=4 SV=1
----------------------------------------------------------------------------AEEEQRFRLAFDDNPTAMAVVDMD
GYLLRVNPSACRLLDRTADELTGTS---FLAYTHVDQAQ-DLAAGK-----LVQVHYTKRLLRKNGDVIYVEIARSLAKDRTGAPRYVIASIRDLTAEIE
AARTVTESELAFENNMAGMVLHNHDGRFIDANDAFCRIVGFNVEELAANGSLFLYPEDAE-MAATDRQRVLSNGSSTQNVRRYRHRSGKIIYVEVARSTV
RDEDDKPLCTITSVRDITAERTLTEQLSHQALHDSLTGLPNRIALMDRIAHAQQRINRQGGVNALLLFDLDDFKGINDTHGHHIGDQILVALSDRLRGTL
RSSDSLCRLAGDEFVYLAEDLSELSDELLAARLLEALSAPFTIDNLTIQRSASVGVVAWGPPGRSAIELIRAADTAMYEAKREGKARYVLYTADMGERAA
TNFRIAQDLVPAISNGELKMYYQPIVNIGNGKIVGWESLMRWRHPEHGWISPDTFIPLAEQNDLILKLGQFALMQSLATASAWPRKGVTPPYVGINLSAR
HFHDPDLLPMVESALKTYDFPPECLVIEITESAALLDIESARRVITSLDELGILLALDDFGTGYSSLSYLAKLHPKIIKIDRSFVSPTVKSPYVQRSLEA
IISLCQVLKISVIAEGIETPSQLGALQSLGCELGQGFLFSKAVPANEVDHTESL------
>tr|W8KTV9|W8KTV9_HALHR Diguanylate cyclase OS=Halorhodospira halochloris str. A GN=M911_16485 PE=4 SV=1
-------------------------------------------------------------------------------DQVPTMIP---------AVDE
LKRIYVSPRLKQWM-DKGRFLKDHD---RWLAHLHDDR--------LQTRTQRAYCLEYRLQ--DG-PHWVRDMGAYIHDGRRERAVIQGLMMEIPDPYD
GAQ--AHLAQLLDQAPMALFAVDDQGQITYVNQQALTQLGYARPDLLGRAAGLLWPDS-------PLHQALCSQALERLETVLWRRDRRALPVHMAITPL
RAGTA-ASGAVITFQDATEYRSMSTQLDYQASHDPLTGLLNRRELMFRLERALHDARRQHVQHALLYLDLDQFKLINDTSGHQAGDELLRRIATLLTDHA
RQGDALARLGGDEFAAILHEVTPEQAMRLAEEMRELVEYRFHWENRQFSLTVSVGLVPVTR-ESSGITLLSAADTACNAAKDTGRNRVHAFKKDDTGLMQ
GDMHWVSRIHSAVEENGLQLFCQPIRPVRKA-GTHFEILVRMRDHDDKLIPPSAFLPAAERYNLSTRIDRWVVRQTLDWMCDQRDRMDHLDACAINLSGH
SVGNSEFLKFLLEALQTSNLPPEKLCFEVTETVAICNLDNARHLFSSLGSLGCRFSLDDFGSGMSSFGYLRDLPVHYLKIDGLFVRDVAQDETDRALVQS
INDIAHVMGKQTIAEFVESDAILQVLREMGVDYVQGHHIGHPVPLHSITLGDRP------
>tr|B8GQU5|B8GQU5_THISH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) GN=Tgr7_3251 P
-------------------------------------------------------------------------------TTPPVLVS---------PDAR
LTRLHISPHFKHLVGAHGAYLKDHD---RWVQYLHEDR--------LGTRAQSPYCIDYRLS--KG-TRWVRDMGIYVGDPQQGGTVIQGVMMDVSLEHE
LREALAKLLETLEHTASAILRLDAAGRISYANQAALRLTGHTRPELLGHDFQALGPAP-------YLKDVLRSQPHHLQGLTLWRKDARPLEINCQLAPG
----A-EGGAILTLEDATEYRSLSTQLQYQVTHDALTGLLNRRELLIRLEQALRQARNGHNNGAMLYIDLDQFKVINDTSGHTAGDELLRQISSLLTGAI
RQGDALARLGGDEFAVILNDCPASEIMDTADQLREHIAHVFRWEDKSYNVTASIGVVPINR-EGNVITVMSAADTACHSAKDKGRNRIHAFKLDDTSMRQ
GEMRWVARIHQAVQEGRFSLFAQTIQPVKHR-GTHLEMLIKMQGEGDELIPPGVFLPAAERYNLSGTIDRWVLQHTFSWIADAGLDENRLSLCAINLSGH
SVGDPAFLDYVVSQLKRHALPATLICFEITETVAIANLNQARTMMETLGGMGCRFALDDFGSGMSSFGYLRTLPVDYLKIDGLFVKDIAKDPTDLALVRS
INDIAHVMGKRTIAEFVESQEILDRLQEMGVDYAQGNFIAEPVPVAELRI----------
>tr|A3ISZ5|A3ISZ5_9CHRO Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Cyanothece sp. CCY0110 GN=CY0110_28874 PE
----------------------------------------------------------------------------HKYQRSETALLIYSRQASD-GF--
-ALTFISNSIQQ-FGYQPEFLKDRK---FWSHCIHEDI-------------------LLNLF--NG-YRWVQDQRKLMRDEMGNATEIIGSWQDITERKE
IEQALFCKEVTLKSIGDGVITTNFSGEVLYLNPVAEKLTGWTVETAKGKPVAIF--ES-------CVCQLLRQICVNDD-ILLISRDGSRYAIDESASPI
YNHNQEMIGTVLVFRDVTKPRQLARKIAWQANHDGLTKLMNRRSFEEQLDRAILEARTHQNSHILCYLDLDQFKVVNDTCGHIAGDELLRQLAELFNHQV
RTSDKIARLGGDEFGILLHQCPLQAGKQIADKLRKLIEFRFTWDDKTFAIGASIGLVEINE-DLDLNSLLSAADAACYAAKDNGRNRLHIYQADDHEVQR
EERQWISKIHLALEENRFCLYQQKIIPVKGQ-NNHNELLIRMIDREGKIVPPMAFIPAAERYDLMPVLDRWVVSHFFKYYSTLT---NKQEIYTINLSGS
SLTSEQFLNFLKQQLKEHPISPETLCFEITETTAIANLSKAITFIRELKKIGCHFALDDFGSGMSSFGYLKNLPIDYLKIDGSFIKDILKDPIDCEMVEC
INRVGHVMGIQTIAEFVESNEILQKLQKMNIDYAQGYGIAKPCPLFDSLQTQNQ------
>tr|A0A060NNN6|A0A060NNN6_9BURK Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Comamonadaceae bacterium B1 GN
----------------------------------------------------------------------------ELE---YQAILQNAGVGI-LFTRN
RRFEHCNPRAAEIFGWTPDALVGQP---GSVLYF-EADP-LLAAGQ--------LFEQERLRRRDGSA-VFCQLRAKSINPHDSADGTIWIVEDISERKR
AEQELRLLLAILDNASVGILFT-CNGLIQHCNPRFEELLGYERGQLLGQSAVFFKSADD----YQRFGAAIGDGQRIEIEWRNRRIDDSLVWMRIMAR-A
LPQAGDEKITIWITEDIEQRKATEQRAAYLTFHDALTGLPNRQLLQERFSLAIAHADRECQRVALLYLDLDNFKHINDTLGHACGDALLQQVAQQLQQCL
RQTDTLSRQGGDEFIALLTDLKDNQAAPVLAKLMANLEQPFVLDGHELALTCSIGVALYPDDGD-FDTLLRKADMALYRAKDLGRNSHHYFNEDMGQQAG
EHLRLRAGLRRALEHGELLLHYQPQFDLRSGALVGAEALLRWQHPEQGLIAPARFIPVAEESGLIAPIGAWVLEEVCRQGRAWLDAGLPPLQLAVNLSAV
QFKRGDLEATVQQALARSGLPAHLLELELTESLLLHNTDAMLALVRRLKLMGVKLSIDDFGTGYSSLSYLKRFEVDKLKIDQSFVRDLLTDPDDAAIVRA
IVQMAAGLGLRTLAEGVESAAVAERIAQFGCDEAQGYHYARPMTAPAFKEFLQR------
>tr|L0KJQ2|L0KJQ2_MESAW PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Mesorhizobium australicum (strain LMG 24608 / HAMBI 3
----------------------------------------------------------------------------------L----------TDAIETE
LR----------------------------------------------------------LKHKQGHWVWVLDRGGVESDADGKPLRLMGVQTDISKQKA
AEAALEQVNLALAASGTGIWHYDIATNKSYWDARTREIFGLVADEVTADLWSYLHPDDKD-AAEAHRVPLGT-DGVIAAQYRIIKRDGQIRHVESLLRFI
AAA-GATGQVLGTVRDITEDKLREQELAFAARHDALTGLWNRAAFDRLLAHHIAT-A---VPLAVFYVDLDYFKALNDFAGHAAGDLALKSVAAGIGRCL
PPSAHAARLGGDEFALMVPDCDAVQAEGLAGAILAAVRADLGLAATSRRLAASIGITVVRDRATTVADALACADDACYAAKAAGRDRFALFSTDAVSGGL
NAARLAADTVDAMDDGRLKLFGQQIHRLGRPESRHVEVLARLAGQGGRLIPPGEFIPAAERFGVAARLDRWIIRTALSRHGAAMK-S-GAITLGFNLSAQ
TLSDPGLWDFVDRVIEETGAPHSGIGFEITETAAVTNFDAAEAFVRKARERRCRVSLDDFGAGMSSFEYLRRFPVDAIKIDGSFIEHVTESRFDREIVLA
ITSIARSLGCAVVGEKIERQDTVAMLADMGVEFGQGFLLHRPEPLERVVAHSAR------
>tr|X6CZ79|X6CZ79_9RHIZ Diguanylate phosphodiesterase OS=Mesorhizobium sp. LNHC252B00 GN=X743_23515 PE=4 SV=1
----------------------------------------------------------------------------------Q----------TNAIETE
LRLKHKQGHWVWV----------------------------------LDRXTNAIETELRLKHKQGHWVWVLDRGGVERDASGKPLRLMGVQTDITKQKA
AEAELEQVNLALAASGTGIWHYDIATNRSYWDARTRDIFGLVADEVTADLWSYLHPDDKE-ATEAHLPSRGS-DGVTASQYRIIRRDGEVRHVESLVRFI
TGA-GAAGQILGTVRDITEDKLREQELAYAARHDALTGLWNRSAFDRQLADHIAA-G---APLAVFYVDLDYFKALNDFAGHAAGDLALKSVAAGIRGCL
PPAAHAARLGGDEFALLVPHCDAAQAERIATGVLGAVRADLGLAASTRKLAASIGIAFIDNANTTIADALACADDACYAAKAAGRNRFAVFSATVEAGGL
NAARIAADTVDAMEDGRLKLFGQEIHRLGRPESRHVEVLARLVARNGRLVPPCEFIPVAERFGIASRLDRWIIRTALSRHGAALR-S-GALTLGFNLSAQ
TLSDPQLWAFVDNVIEETGAPHSGIGFEITETAAVTNFDAAEQFVRKARERHCRVSLDDFGAGMSSFEYLRRFPVDTIKIDGSFIEHITQSRFDREIVLA
ITSIARSIGCDVVAEKIEKQDTLTMLSDMGVAFGQGFLLHRPEPLEAIVSRATE------
>tr|X6FJ95|X6FJ95_9RHIZ Diguanylate phosphodiesterase OS=Mesorhizobium sp. L48C026A00 GN=X737_37505 PE=4 SV=1
----------------------------------------------------------------------------------L----------TDSIETE
LR----------------------------------------------------------LKHKSGHWVWVLDRGGVERDAEGRPVRLMGVQTDITKQKQ
AEAELEQVNLALAASGTGIWHHDLAARKSYWDQRTRDIYGLVADEVSQDLWSYLHPDDRA-DAEAHVAPLQT-QKVVAVQYRIIKRNGEIRHLESLIRF-
ADA-QSSGQILGTVRDITEAKQREQELAHAARHDALTGLLNRAAFDRLLAEHIATARR----LAVFYVDLDYFKALNDFAGHAAGDLALKSVAERILGCL
PPSVHAARLGGDEFALLVPDCDAAQAERLAGAVLAAVRADLGLTATSRKLAASIGIAFVADANTAVADALACADDACYAAKAAGRNRFAVFSPETTSGGL
NAARLAADTVDAMADGRLKLFGQEIHQLGKPESRHVEVLARLAGRNGRLIPPGEFIPAAERFGVASRLDRWIIRTALSLHGPALK-S-GALTLGFNLSAQ
TLSDPQLWDFVDAVIAETGAPHSGIGFEITETAAVTNFAAAEQFVGKARERRCRVSLDDFGAGMSSFEYLRRFPVDTIKIDGSFIEHIADSRFDREIVSA
ISGIARSLGCSVVAEKIEAQDALDILADMGIAFGQGFLLHRPEPLQAIVARACA------
>tr|M5FFX8|M5FFX8_9RHIZ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Mesorhizobium sp. STM 4661 GN=MESS4_740016 PE=4 SV=1
----------------------------------------------------------------------------------Q----------TDTIETE
LR----------------------------------------------------------LKHKSGHWVWVLDRGGVERDATGRPLRMMGVQTDITKQKE
AEAQLEQVNLALAASGTGIWHYDLAARKSYWDARTREIFGFVSDEVPRDLWSYLHPDDKD-DAEAHMAPLQT-RDVVAVQYRIIRRDGEIRHIESLVRFI
ADA-QSSGQILGTVRDITEAKRREQELAHAAHHDALTGLLNRAAFDRLLADDIATARQ--FPLAVFYVDLDYFKALNDFAGHAAGDLALKSVAEGIVGCL
PSAAHAARLGGDEFALLVPDCDAQQAERLAGAVLAAVRADLGSTATSRKLAASIGIAFVHDQGTTVADALACADDACYAAKAAGRDRFAMFSTEGASGGL
NAARLAADTVDAMEDGRLKLFGQEIHRLGKPESRRVEVLARLVGRSGKLIPPGEFIPAAERFGIASRLDRWIIRTALSLYGPALK-S-GALTLGFNLSAQ
TLSDPQLWDFVDAAIDEAGAPHFGIGFEITETAAVTNFGAAEEFVRKARERHCRVSLDDFGAGMSSFEYLRRFPVDQIKIDGSFIEHIAQSRFDREIVSA
ISGIARSLGCSVVAEKVERQDALEILQEMGVAFGQGYLLHRPEPLEAIVARATV------
>tr|A0A095SKG9|A0A095SKG9_9GAMM Signal transduction protein OS=Alcanivorax sp. 19-m-6 GN=Y5S_01565 PE=4 SV=1
----------------------------------------------------------------------------RRRDSADDAGYHHTGVGMA-LSAK
GDWQHCNPAMSRLC-DQPAQLFQRP---FTDLFYPEDIR-WVRLTLTIAEKG-------------------------MELE-----STQAAHDARTELIN
QQQRLARSEVTLDAIADAVITTDACGAITFMNPMAEALTGWTDQNAVGRPVEVL--PS-------PVNEALQGVCFLREGSRLRSRDGSSYEIQDTASPL
TADDGRLVGAVVVFRDVSSHKAMEKALDYQATHDALTGLTNRAGFELALKRALSDER--QESAILCFINLDRFKVVNDTAGHIAGDALLRECAGVIGRQI
RDNDVLARLGGDEFGLLLRQCPLGRARNIAERLIDALNIRFDWESAVYDIGASVGLVELDA-QTTVEEAMSRADVACYAAKHRGRGQVMEYTAEDSDARH
LELQMVASLRESLEANRFVLYAQEIRAM-DE-PGHYEVLLRLRGRDGEIISPGAFIPAAERYQMMPHIDRWVLRQLLLERGEELA--GTGLNLAINLSAT
TLDDPGFLSYLERLLAETPLEAQRLTFEITETTVVNQMGSVSEVLIWLRDQGCKVALDDFGSGFSSFNYLKHFKVDYLKIDGSFVRNLVRSSVDHTIVES
INEVAHRLGIQTVAEYVEDEALIPLLRETGVDFVQGYAIGLPEPLDALFKRHRQ------
>tr|A0A0A0B6C5|A0A0A0B6C5_9CELL Uncharacterized protein OS=Cellulomonas cellasea DSM 20118 GN=Q760_13915 PE=4 SV=1
----------------------------------------------------------------------------LGGVRLPDAMVDALQEGVLICDAR
GVVVDVNEAAGTILTLDRDSLLGLD---LAALDYDADAP-VAVVRR-TN-QP--ASATVKVRRGSPNPLWLRATAIPFVPVADEV-WCMVTLTDVTGAQN
AQQRLRHSELTFEDAPIGMAIVSLDGRYVEVNRALTESLQRTREELVGASFDITHPDDLP-SDLAHGARLLDG-DSFQVDKRYLTPGGDTMWARLTVSVV
RDGDGSPVHFVNQIEDVTEMRLAQEQLERRALYDHLTGLANRSLLLDRLAHALTQHARTGNLVAVAFADLDHFKRLNDSLGHDAGDRMLRAVAERMTAAV
RPGDTVARIGGDEFVVVLEGVDSAEHGELLDELLTAVELPLHIDGHEVVPRLSAGLTVNDGTG--AEEVLRDADTALYVAKDAGRSRWEVYHDVYRRDAL
RRLSVETELRTAIDRGQFLLHYQPVVELDTRRTVAHEALVRWMHPRRGLLLPGEFVQIAEESDLINGIGGWVLREAVEFLARH----PLPGKVYINVSPR
QLGRAGLAPLVEQVLRANDVPASRLGIEITENGVLQATEQTREDLEQLAALGVELLLDDFGTGFSALTSVLSTPVSGLKLDRSFTVRLGDGAACDRISTA
IAALVDSLSSHGVVEGIETEKQWALALGHGWTHGQGWLFGHAVAESALFPVVDT------
>tr|U2FWG0|U2FWG0_9GAMM Two-component system chemotaxis family CheB-CheR fusion protein OS=Salinisphaera shabanensis E1L3A GN=SSPSH_000788 PE=4 SV=1
----------------------------------------------------------------------------LVRHQRVQRLL----DVLYHTDNE
GRISWITDTVTDMLGYRPGELEGRP---LRDVLANQDE---------LHR-------PTRVYRR---IAWLLISSRRIDDAAGNAIGSEGVCRDGTRLIE
TQQALNEKEVTLASIGDAVITTNAAGAVDYLNPRAEQMLGVNVDDATGRHFKLC--NG-------LVHKCLASLQEHDEDLTLYDRAKTGHTVKVTISPI
RDSDQVITGTVIVLHDITRLQQISREMAYQANHDLITDLPNRRAFEQSLDQALAVVD-EKHSHVLCYIDLDQFKLVNDTCGHNAGDEMLRQIAARLGSCI
RANDTLARLGGDEFGLIMRDMSPSDAQAKAEELRTKIDFRFRWDEKLFRLGASVGVASIDR-EIDATELLRRADTACYLAKEKGRNQVYVYHGDSDETRH
GDMQRMQQISEALDSNSFELFAQFIQPIEHE-RCGVELLLRVRDTDGSILSPQNFLITAERYNIAPRIDRWVLHRAIRLITQAGDDHAAIEHYSINISGQ
SITDEHFVDYARGLIEASSVDPHRLVFEITETAAVTNTHRAGELIRSLRALGCRFSLDDFGSGLSSFSYLKNLPSDFIKIDGKLVSNILTDPVERSIVEA
INQVGQAMGLLTVAEHVETRAMLDALRAIGVDYAQGYYVARPIPFEMLSAALGT------
>tr|A0A084IQG1|A0A084IQG1_9GAMM PAS/PAC sensor(S)-containing diguanylate cyclase/phosphodiesterase OS=Salinisphaera hydrothermalis C41B8 GN=C41B8_02407 PE=4 SV
----------------------------------------------------------------------------LVRHQRVQRLL----DVLYHADRD
GRLTWVTDSVSDMLGYTSHELRGYP---LSGLLADDTD---------IVR-------PTRVFRR---IAWLLISARRIDDADGQITGSEGICRDGTRLIE
TQRQLNQKEVTLAAIGDGVVTTDADGTIDYINPRGLHMLSRSMKQVQGRAFDVC--DG-------LVTECLTTSREWANTLALIGDQDDYRSVTVTVSAI
RDEKSQIIGAVVVLHDVTRLERVSRELTYQANHDSLTGLLNRRAFERRLKHVLETTRLDKVHHTLCYLDLDQFKLINDSCGHHAGDAMLRQLSSQMVTQL
RPNDTLARLGGDEFGIIFEETDLETAQAAAERLRQWLEFRFEWEGKAFRLGASLGLSVIDE-GASAAELLRRADTACYLAKEQGRNQVRVYHRDSDEARD
YEIERMQKINEALDDHGFVLHAQPIAPLADS-RMGSELLLRMKGEPGAMISPQDVLLTAERYSMASRIDRWVIDQALRLIGRHDADCPRIGYYSINISGQ
SITDEQFVGFVRECIEQSGVNPKRLVFEITETAAVTNLQRAADLMRSLRAIGCRFALDDFGSGVSSFSYLKHLPSDFVKIDGKLVRHVTEDPVEHAIVEA
LSKVSRAVGLRTVAEQVETKEQLDALERIGINYVQGYYIARPMPFEQFIESMKT------
>tr|H0IXW0|H0IXW0_9GAMM Ammonia permease OS=Halomonas sp. GFAJ-1 GN=MOY_00980 PE=4 SV=1
------------------------------------------------------------------------------------VML----DGVITWQSD
GTLTGLNPGAEALFGVNAQQLVGQP---VSKLFPNNTL----------LRKE--Q--QVRYLEI--------------------ASECSGMVRDITERKQ
LQEQLNRRDITLASIGDGVITCDVSGNITFMNTEAQRLTGWTLEDAINQPIIVY--NN-------PARQVLTQVQYSEH-CQLLHRYSKRHPIQHSAAPI
RSRRGITLGAVVVFQDVSLTQKLSEQLNYQATHDNLTGLVNRRAFETVLTKLLEH-P--EHSHVLCYLDLDQFKIVNDTCGHLAGDELLRQVAVKLKTHV
RNSDTVARLGGDEFALILPDCPLDKAAHICEAVRTDIEYRFVWQNHTFGIGVSIGLVPITPAHMHLSDALHAADAACHIAKEAGRNRIHSHQPSDRHLRH
GELQWIQRLQNALDNDTFRLFAQPVSAVKP---GYQEILLR-LEENGILISPGSFLPAAERYHFMTRIDRWVIRNTLAWLTDRHRGSDEIGYWGINLSGE
SLSDSAFCHELIQQVRKAGLPAGSLCFEITESTAIAQLSKVSELIQSLKALGCKFALDDFGTGLSSFSYLKQLPVNYIKIDGSFIRNIHHDPIDKAMVQA
IHAVGKALEIDTIAEHVETQETLDTLRSLGIEYAQGYLLGRPEAITETTDNSIR------
>tr|L9PJ61|L9PJ61_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Janthinobacterium sp. HH01 GN=Jab_1c01980 PE=4 SV=1
------------------------------------------------------------------------------------MAL----MTIWDSELN
EGRVL--DSTVKWFGA-GATLLGLP---FGDLLQPFAVQ-LLDTMQA-VDRG-TYEVEYRVVWPDGP-----------------PLGTLGVVWDITERKD
NEQTTARREVTLRSIGEGVITTNADGVTDYLNYIAEQLTGWTHDEAHGLHINTL--EH-------VALQCLRLIGMSSQ-NQLVTRDGRHVAVEESAAPI
WSDNGELLGAVVVFRDVSHERKLTKQLSWNASHDTLTGLINRREFEVQIADALHSSKEDCHVHALLYMDLDQFKIVNDTCGHSAGDLLLQLLSKMLQTQM
RDSDILARLGGDELGVLLPHCPPDQALLIADELRQSVKFRFVWDDHTFELGVSIGLVEINH-HKSMTELLIAADQACYLAKERGRNRVHLYQESDQRLRQ
GEMQWVSRLNEAFEHQYFRLYAQPIVRLDE--EAHDEVLIRIQPAKGDLILPGAFIPAAERYDMMTAIDRWVIRAVCRHVQSQGARQDPPAQYSVNLSGT
SLGDEGLHDYIVEQFIEHDVAPAQICFEITETAVIANLIKAQDFMAGLKALGCRFSLDDFGSGLSSFAYLRALPVDFLKIDGVFIRDIATNAINRAMVKA
INEVGHVMGISTVAEYVEDEPTLAVVRELGLDYAQGYAVGTLRPLSGGV-----------
>tr|H8GRG0|H8GRG0_METAL PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Methylomicrobium album BG8 GN=Metal_3490 PE=4 SV=1
-----------------------------------------------------------------------------RLQNQNQQILENSPDIIFLMNEA
GSFSYLNKAVETILGWPLAEMTGQH---YSKFVCKEDSM-TVQLRLR--RAS-----EFRHV-----DPYSIDLFHTSGSHVRELPRIFGVIRNIHERKL
VENDLCKYH-AMDNSPNFIFITDRNGVIEYTNRKITETTGYSTSEVVGKTSIFS--WD-------TVS-----GQVWRGVLRNQKKSGELYWARESIAPV
INSEDEITHFVAIQEDVTEALQLTEKLAHQASHDALTQLINRQEFDRRLERVMALTRNSNAEYALCYIDLDQFKIVNDTCSHAAGDELLRQISGLFSQVI
RRNDTLARLGGDEFAILMESCPLESAVAVTDNIHRAVEFQFFWQDKSFRIGVSIGLVMVDI-RGGSDIHMKQADMACFAAKEAGRNRTHIYRADDKALHH
GEMNWAVRINNALEQDLFCLYAQDIVPL--E-GEHCEILLRMKDRNCNLVSANAFLPAAERYQLATKIDRWVIRNVFDYFTENHKRLEDLSLCSINLSGS
SLSDPHLLGFIESEFVRTAMPPAKVCFEITETAAIANLTLATDFMRRLKEYGCKFSLDDFGSGLSSFAYLKHLPVDFLKIDGFFVKDIEHDSVDLAMVKS
INDIGHMLGKKTIAEFVENQVILQTLNGLQVDYAQGYFTGKPKPLYENDTLCQV------
>tr|D8VMU3|D8VMU3_9ZZZZ PAS-PAS-GGDEF-EAL domain protein OS=uncultured organism PE=4 SV=1
----------------------------------------------------------------------------EQERNLMRTLVDAVPDSIFVKDLN
SKFLLANNAVARGMGTSPENLIGKD---DF--DFFEEMA-IVRTGE-LV-N----REELAVNKETGNMRWFLTTKLPVRNDKGETVALVGIGRDITLRRR
AERALRESESLIELSSDWYWEQNADLQFIEFEDPNNK-SSYKRDEVLGKHLELPGTALLS-ESWIEYDDLVAE-FR-DLELRRVADNGKAYFISLTGLPA
FDENGKFRGYRGIGRDITDRKRSEQHIHFLATHDSLTSLPNRFMFSQILNLAIESAHRYHRKLAVFFIDLDRFKNINDTLGHEAGDFLLCEMAARLKQCL
RASDVVGRLGGDEFVILLPEPENTEQATVAQKILSASINPIDINGQECRVTASIGICVYPEDGD-EQTLMKNADIAMYRAKEEGKNNYQFYSPDIEARSL
ERLMLENNLRMALERNEFFLHYQAKRNLQTGEIAGVEALVRWQHPELGVISPAQFIPLAEETGLIVLIGRWVLKTACAQNVAWLKQGLPPLCMAVNLSVR
QFFDEHLIQDVADALSESGMQPELLEMEITEGMVMQDAERAIRILTAIKALGVRLAIDDFGVGYSSLAQIKRFPIDTLKVDSSFIRDIPQNREDRAITEA
IIAMGRTLSLTVIAEGVETKEQETFLRDHNCDQSQGYYFSKPISPEDFVSFMKK------
>tr|D5XC43|D5XC43_THEPJ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thermincola potens (strain JR) GN=TherJR_2660 PE=4 SV=1
----------------------------------------------------------------------------FFTWNNLDQLYNMIPSAIFTVNTN
RIITSINNKAANLFGYPAEEIVGRS---CTEFCYGCCSP-KPATGE-II-K----T-------RSGLVRIILKNIDLLRDNEGAIIGGIETFEDITERKK
TEEALAESETLFERTASPILVTDTKGNYIDCNEAACQFLELSREELLTLN----VRDLLP-KGWEKRPQAHKI-TEGVIEAEYLI-KNRIKIMELTVTPA
IWQG--KAVVFGVGKDITERKQAEEKMRRMAYYDSLTGLPNRAFFKEKLTAAIIKSRSKKQKLAILFLDLDRFKTVNDIMGHDVGDQLLKDVAKRLKKRV
GKGRVVARLSGDEFIILLPNVSRIEDRKFAEDVCENLRKPFTIAGRNFHVTTSIGITVFPDNGD-AKTLLKNADIAMYKAKEQGGNSYEVYTFAMNEMAM
AKLELENSLRAALERHEFTLFYQPQVHGMTGEIVGMEALIRWKHPEKGLISPAEFIPVAEETGLIVPIGEWVLYTACMQNKYWQQKGYAPIRVAVNLSAR
QFQQRNLVSMIARVLKQTGLDPNCLELEITESVAMQNLENTIKLVKQLKDLGVHISIDDFGTGYASLSYLKLFPIDTLKIDRSFVRDISQNPRNDALVAT
MIVLAKNLKLKVVAEGVENEKQLKFLLERQCDEFQGFFFGKPVPAKEFEQFLTR------
>tr|I7ZES2|I7ZES2_9GAMM Uncharacterized protein OS=Hydrocarboniphaga effusa AP103 GN=WQQ_05310 PE=4 SV=1
----------------------------------------------------------------------------MLAAAQDQAIFSTVPVGLAIVGLD
SRLLTVNDALCELLGHSKAELMELN---FRAIT---HRD-DAELFESALASRERFRAERRFVAKDRSVIYAQLDLTLMRDSDGLPLHFIAAISDRTEERL
QLQMLTKQRITLSSIADGVVRIDESRCITYANPAACQMVGLDLDELRHRPFEYVIVGDAP-EGPDVLAEVFDGTLQFPSGTLLRFLRGREIAAECSAAPI
KDALGYVREAVFVFHDTTESNTLARELAYQASHDMLTGLCNRRQFQSAIEKSYAALVEHGTPSAVLFIDLDGFKAVNDRHGHQAGDDVLVWVASVIRQAV
FKRDVPARWGGDEFAVLLINCDADRAHDVARRIEAELTSQV-RLSDYSGISGSIGIACMSASDASCMSVVNNADLAASIAKGRGGGGIQRFEDIRAQVRR
SLFEWRREILQSLKEGRLIPYGQKIVG-GDGELLGYEMLLRWVDTSGRVNTPERIIDAAERLGWSTRIDGFVFGVASRLMLSGQV-P-EQVHLAVNVSGR
SLADADFRDTVTSFFSDHPQVASRLTLEVTETAAVSDLNLVGAFVSRLRELGCVFALDDFGSGFASFSYLKAIPFSAVKIDRAYIRALDRDPTNQLIVRN
LCELGGHLGVTLIAEGVETQAELAALKALGVSRFQGWLFQKAEPLPWSW-----------
>tr|N6YWP2|N6YWP2_9RHOO PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Thauera phenylacetica B4P GN=C667_16226 PE=4 SV=1
----------------------------------------------------------------------------VALKNDYAAILQALPDPLFVLDAE
GRCLSYR---------TPSEDLLAA---PP--VLPAEAC-LEALREARVGSTGKVFRVD--APG--GTRWFELSVA-MARSAGEPQRFNVLSREITARKQ
M-----EQAESLLRAVD-------NTPVEYWARDLQGRCIMQNA-MTAAHWDLL-SAPVS-A-----RRAYAGTLHKEV---EYEVDGERRVFQCLVAP-
IRVQGEVMGIFGFNQDVTERKRQERQIHELAFFDPLTGLPNRRLMYDRLEHALSTSARRGTEGVLLLIDLDHFKDLNDSHGHDAGDQLLVEAGVRLNACI
RQGDTAARLGGDEFVVILEDIEGVAQNTIATRIGEALARPFHLRCVVQHVSASIGVGAFGRGELSAAELLRRADTAMYQAKAAGRNAICFFDPAMQAAVT
ERATLHADLREAIRSRQFELHYQVQVDT-RRRPVGAEALLRWRHPHKGLLAPGGFIELAEETGLIVPIGHWVLETACRQLARWAQRAQAHLRLAVNVSAR
QFRQPSFADEVRALLESTGAPAERLKLELTESSLIEDAEAVIERMQALRALGIRFALDDFGTGYSSLAYLKRLPLTQLKIDQSFVRDVMSDPNDATIART
ILALGSNLGLAVIAEGVETEEQYDFLAAQGCRDYQGYLFGRPVPMEVFEAALAQ------
>tr|C4ZLC1|C4ZLC1_THASP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thauera sp. (strain MZ1T) GN=Tmz1t_0532 PE=4 SV=1
----------------------------------------------------------------------------VGLKNDYAAILQALPDPLFEFDIE
GRCHGYR---------TPDEDLLAA---PP--VLPEEAC-LEALREAAKGSTGKVFKVE--APQ--GTRWFELSVA-MASAAGRTQRFNVLSREVTARER
M-----ERAESLLRAVD-------NTPVEYWARDLDGRCTLQNA-MTVAHWDLL-EPAAR-T-----RRAYAGTVHREV---EYEVDGETRIFQCLVAP-
IRVGGEVVGIFGFNQDITERKRQEHQIHELAFFDPLTRLPNRRLMFDRLERALGSSARRRHQGALLLIDLDHFKELNDSHGHEAGDQLLMKVAARLGLSI
REGDTAARLGGDEFVVILEDLEDVADKAVADRIGRELGRPFQLQRISYQCSASIGISAFGEPGVGAAELLRRADTALYQAKAAGRNAVSFFDPIMQAAVT
ARARLHSDLRQAIRGGQFELHYQVQVDA-QRRPAGAEALVRWRHPEKGLIHPGGFIDLAEETGLIVPLGHWVLATGCRQLALWARHPAAHLRLAVNVSAR
QFRQPSFADEVRALLEQTGAPADRLKLELTESSLIEDTEAVIERMETLRALGIRFALDDFGTGYSSLAYLKRLPLAQLKIDQSFVRDLMSDPNDASIVRT
ILALGDSLGLAVIAEGVETEAQYAFLAAHGCRAYQGYLFGQPVALDVFEAGLAA------
>tr|A1W1Y4|A1W1Y4_ACISJ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax sp. (strain JS42) GN=Ajs_0003 PE=4 SV=1
-------------------------------------------------------------------------------------MVDGVAQPNAEYVLE
G---------------TPSERLLTQ---RS--RFPAPVS-YVGQQLTSDGPIGMIFVVF--RQTLERSRFVSNTL----------QIFAARAAAELQRQT
D-----DQRASLLDKADAIIVRDLEHRITFWNEGAERMYGWSREEVLGRSITLL-ATQ---------HGVWSGILQCDRAGRTLEAEGRW------TLV-
RNDRGEPESVLAINADIGTRKHQEREIQRLAFFDPLTHLPNRVQLLDRVDQALAKAQRLEQGGALLFIDLDNFKTLNDTLGHDQGDELLQIVAQRLNTCV
RSADTVARLGGDEFVVLVEQLSAHSDGAVGEKILAVLSAPYALTGYQHRSTPSIGIALFNHAPTTVGELLKQADLAMYQAKTAGRNTLRFFNPSMQHAVA
ERASLEADLRNALAQKEFLLHYQPQINA-RGAIVGVEALLRWAHPRRGMVSPGQFIPLAEETGLVLPLGHWVLHTACSVLADWQRVPAAPLTMAVNVSSR
QFRDAGFVDDVAGVLAATGAPASQLKLELTESLLVEDLAATIATMAALRALGVGFSLDDFGTGYSSLAYLKRMPLGQLKIDQSFVRDLLTDPNDAAIVRT
IIGLAASLGLEVIAEGVETSAQRDWLAHAGCAVYQGYFFSRPLPLDLLEQLLHD------
>tr|D3F544|D3F544_CONWI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937
----------------------------------------------------------------------------QRARQALRAAERLSRLEEGVLVLD
AN--LHPVSWNRILGVTPEQLADVE---QLAQA-PTMSP-ALRSLRHA-----PVRATLHRETETGRERWITILARIGGAHGTSRRGVVCTFADVTSSVE
AARRLREERHYLEVASTLVVVLDAGGRVELVNRQGCELLGYAEHELVGRDWETVPPGDRR-DARAVFAQLLAGLPAERGETFLLTKAGEERKIAWRNAVV
RDATGTVASVLCSGEDVTERRRAEAQLAYLAHHDRLTGLPNRAPLEEQLQRDLARARRTGGSVALVQVGLDNFKLVNDSLGHAAGDAVLSETAQRVAQLT
RAGDVIARQGGDEFMLLLDCGAEEAQQLAGDRVMAALEQPFAVAGAEFHIGASIGIALFPGNANNAESLFKHADMAMHQAKRSGGGAVVFYERG---AAR
ERLSLTSRLRRAIDGDELRLHFQPIYRVEDGVLVAVEALVRWEDPEHGLVPPAGFIPVAEETGLIEGIGSWVVEALCRQASRWAREG-FRPRLCFNLSPR
QLRQPDLVDSIARTIARHELPPGQFCAELTETAVLSDERRHSSLLDELHEAGLAIAIDDFGSGHSSLARLRDLPVQVLKVDRSFLRRVPEDPGSTAIVAA
VLELGTALGMTTVVEGVEDDAQLALLRRHGAPLAQGFLLGRPVPADQLDRSPAP------
>tr|K9XSP0|K9XSP0_STAC7 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Stanieria cyanosphaera (strain ATCC 29371 / PCC 7437) GN=Sta743
----------------------------------------------------------------------------KASETKNQAILDYKKQQIKPSFSQ
KRVNLINQTISK-FY---SKTTSKK---FWQLVNQLTT-------------------EYSVS--------TANISPLS------KDTVIWVARDISSLKQ
IEQALSLQEVTLQSIADAVITTDANGKVNNLNPMAEQLTGWTEEEAYGLNIEVF--TK-------TLELVLKQVCLSTD-TVLITRDGSEYAIEDSAAPI
YNYQGDVIGMVIIFHDVTGSRQLTRQLSWQARHDPLTGLYNRLEFERQAQQTIIAAQQEDSHHILCYLDLDQFKLVNDTCGHAAGDELLRQVTNLMQRRV
RTTDVLARLGGDEFALLLYHCSLTEGEKIANTLRELIKFRFTWQKNSFTIGVSIGLVTIDR-NTNLNQVLSAADATCYAAKQKGRNCIQVYAPEECNLQQ
GDLPWINRLNQALAENRFCLYWQNIAPVRSQ-RKHYEILLRLIDETGAIILPGAFIPAAERYNLMPTIDRWVINTFFKLYEQCCQK-ESDNIYTINLSAT
TINQGELCQFLKEQFSLYTISPNNICFEITETTAIANLTQATQLIQELKQLGCYFALDDFGSGISSLTYLKNLPVDYLKIDGSFIKNITNDPIDRATVEA
FNRISHVMKIKTIAEFVENEDILASLKELEIDYAQGYGIAKPIPLSFACT----------
>tr|A0A078MJH2|A0A078MJH2_9PSED Diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. 12M76_air GN=BN1049_01770 PE=4 SV=1
------------------------------------------------------------------------------------QVF--SPAPAVLLSRG
LQVLACNNAFERMLAL-PQAMLGQT---LFHLFPGEDSH-QIPLL------------EYPMP--AACEYWSFHNTPLMEEGEVGAILCQPL--NLSALVQ
IEQELSQRELFQQAPGFICILRGPDHVFELANDAYYQLIGHR--HIIGQVLDVL---D-------KLDRVYRTFIGRAVPIELQR--LEERFIDLTYQPI
NDASGKPSGIFVLGHDVTEAHRLSQEVTFQAAHDALTGLRNRREVARQMAE---L-EQAGGSHALVYLDLDHFKIINDRCGHRAGDKLLTEVAQLLRQHA
EEDDTLARLGGDEFAMVLRNCGLDGARRRAQQVCDAIRLPFPWQGRRYTVTCSAGVACFGSEAVTFSDGLGLADAACFLAKEKGRNQVVVGQPSDEEVRQ
QDMDWTDRLREAMREDRVVLFGQRFDNLREEGMICCEVLARLRGVDGELIPPGAFIPAAERYGLIGELDRHIIHKAFSTLQQLHPAQRQRTRYFINVSGL
TLGSRGFVEYVLSTLARFDVEPGNVCFEVTETAAISSLTTTAGLLGELVGRGFQVALDDFGSGMSSFAYLQHLPVQYLKIDGEFIKGIRNPPAGGVIVES
VIQVARAFNIRTIAESVEWSDLVPVLRDAGADYGQGFALHRPQPLPL-------------
>tr|U9VMY4|U9VMY4_9CYAN Pas domain s-box diguanylate cyclase domain-containing protein OS=Leptolyngbya sp. Heron Island J GN=N836_22120 PE=4 SV=1
----------------------------------------------------------------------------RVSEQRFRHAIAMAPFPIMLHADD
GEVLHINSTWTQLTGYTQQDIPTTA---WAALAFGNSTP-TAAMA----------HEAVTIYTAQGQRIWTFSS-STLESLTDGRCIMMTMAVDITQSRQ
TESALKDSESIYNQAAVGLANGSLNGKFVDVNPRFCEMLGYSREELLAKSIEITYPADRA-QSNAILQSLFTD--YCFHEKRYLRKDGSYFWCSIGTSLV
RDVQGNPKHTLAVIRDISDRVKVEEQLKHDALHDELTGLPNRSLLMERLELALKRTKRHPETLAVLFLDLDNFKLVNDSLGHLVGDKLLLAISAKLELVI
RETDLAARLGGDEFVVLLEEINDLAEIMVAERILEIFKSPINIGSRELFPGVSIGIALAKYNHYQASDLLRNADVAMYWAKHRGRGQYMVFDANMHLQAV
QRLQIENNLRRALENEELLLHYQPIINLKTQKVESFEALLRWQHPEAGLLMPDRFVDIANEIGLISSIEEWVLRTVCQQLVCWQTLFPRSLGININFLDE
RLE-ESFLLRLEKILTFCRPADNSLRLEFTESSLVQNFETAQSLLDRLRDMGVEIVIDDFGVGYSCLRYLHQLPVNAIKIDPSFIGPTDLNEVNHVVTES
MITLCKSLGLQTIAEGIKRQQQLDWLTEIGCDAVQGEYFVGPISVREATGLLRE------
>tr|K4KIV8|K4KIV8_SIMAS PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Simiduia agarivorans (strain DSM 21679 / JCM 13881 / BCRC 17
------------------------------------------------------------------------------------SLL----D--FLADAQ
GRVLWANQRAEKAL--------------LINSLLPRVT--------VQFQQG-PFVQ-------DSSLRWRAI--------EARPEGWLLLLEDISESQP
FRDELVSRELALFSVADAVILTDERGMVTALNPSARSLLNVGAHSAMGVEVNLF---P-------CLVRALTRLSNAASNAQLFVSGEEPMAVDAMAAPF
RDGQRRVAGCVLVFRDASGSRRTTARMNWQATHDGLTQLPNRLQFEAELAREVARAKCGNAGHGLMVIDIYQMRVINETCGQAGGDQLLVQLAQTLAASL
RRQDVLARIGSDEFGVLLRGATLAGTQRVADAMIQSVQLNFEWEGQRIKAAISIGAMAVDV-DESESQALAAATAASEAAKETGRNRIHLHHNLNAAVRR
SQMHWVGKISAALAEDRMVLYAQPLVPVHAR-ISHVEVLVRMLDDDGKLVAPGQFLPAAERFGLMDEIDRTVLIKVVEFIERCPDKR---VSFGVNLSGT
TISDETFAQFVHSEIEASGIDPSRLHFEITETAAVANFRAAVHLIKSLRGLGCKFYLDDFGSGLSSFGYLRDLPVDFLKIDGSFVRAMTPGSIDLAMVSS
INHLAGVIGLKTVAEYVENAEVLGLLQDIGVDYAQGYFFSPPKPLETLLGLAAA------
>tr|J0KP10|J0KP10_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_02402 PE=4 SV=1
------------------------------------------------------------------------------------DIL----P--VAEQVL
GYPHCW-------LGVYG---LKPG---FVSILLHSSQR-TNK-EIVALHR---TIINIPLILAEGPLPWQID---FMQAMGAHVAVAMDRVRFMQARKD
AEDALYHKEVTLHSIGDAVISTNAQGDLLYINPAAEALTGWSLTAAVGKPYEVF--AP-------DMM-AGAIQALRYPELQLQPLQGGRVLVEATASPI
KDADGEVQGAVLVFRDVTEQRRLSHEIAYQALHDELTGLGNRRAFEQALACAFDGTRGTARHDVVCYLDLDEFKVVNDTCGHTAGDAMLREISGLFASLL
DEQDLLCRIGGDEFGILLTKRSVASALQLADRLQQALAYHFVWLEQRFGVGVSIGMVAFDA-QESVGALLQAADSACYVAKDAGRNRIHLYAIDDPALRY
GVMEWVSRIEHALLHDRFELFAQPIVPLDEQ-GLHCEILLRIRSEQGELVLPGRFMPAAERYHLAARVDRWVVTHALRWVVEQQDRI---GQCSINLSGQ
SLGDAAFTAFVLQALQHADVPCSKLCFEITETAAISNLHTANHFIEALRASGCKISLDDFGSGLSSFAYLRNLPVDVLKIDGQFVRDIDRDPVSLAMVKS
IHEIGCLMGKRTVAEFVESPALVGILQKIGVHYAQGYAVGHPVPLAQVLEGHRA------
>tr|S6GK59|S6GK59_9GAMM PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Osedax symbiont Rs2 GN=OFPI_29140 PE=4 SV=1
------------------------------------------------------------------------------------AIV----VGIFVINHK
SKLICWNQWMVSSSNIEASFALGKT---LDEIFPDL--H-PLPLYSTSEQKGQVMS-QMIMVKPSP--------------------ARDQLLRQ------
-RTSEYRKEAILASIGDAVITTDLQSHIDYMNPIAETMTGWALGESKGRPLQVF---D-------FVERCLSTPDNESHELALNNRDGVCIAIEESVAAI
RDTDKKIIGAVVVFRDVSSARKLSQQISWQATHDTLTGLFNRNYFDAKLTDMVTDAREGDRHHALLYLDLDQFKVVNDTCGHVAGDELLRQVSLLLSSHI
RANDTLARLGGDEFGIQLLNCPAQVALRIANQTRHSIGFRFCWEDKSFGIGVSIGLVEVNS-QESVEQVLSDADTACYAAKDNGRNQVHVYRTHASEARQ
SEMEWVTRIQSAIEQQRFRLYFQTITPVND--SNHIEILIRMLDTDGEVISPGAFIPAAERYNLMPAIDHWVIGKVFQLINDNLMVLINGYQFAINLSGH
SLSGADTLDYICDQLTKQQIPKGMICFEITETAAISNLSSASHFIRTLKQQGCLFSLDDFGSGLSSFAYLKNLPVDYLKIDGSFVKDMATDVIDQAMVQS
INQIGHVMNLKTIAEFVESEEILQCLKDIGVDYAQGYAIAKPTPLTDSDGKLLI------
>tr|I3IJW4|I3IJW4_9PLAN Two-component response regulator OS=planctomycete KSU-1 GN=KSU1_C0413 PE=4 SV=1
----------------------------------------------------------------------------TMANQSFHRMFN-----TTKEETE
NKYELGNGQWNPRLRMLLEEL--------LLK-----N----MQFRD----FTIEHNFPNIGYKM--MLFNACKIY---KKDKQVEMVLLTIE-------
DITRIKRAEKLSQVVENSIAITDTRGTIEYINPKFTQITGYTSEEIVGQNLILKGGITHE-EYK-CLWDTV-TGCVWQGEFHNMKKDGDSYWTDVCISPI
RNSEKDIINFLVIMEEITERKHCETHLMYLADKDPLTNLFNRRRFHKELERWVAHAQRYGTNGALFFLDLDNFKHINDTFGHQVGDELLIKFANLLREQM
RETDILARLGGDEFAIIIPYADEGKARSVSRKIMGLMRNILINEIQPLGISVSIGIVLFPEHGNEVETLLTYADLAMYSAKEEGRNRACIFSPAHKIQFE
TRLIWERRIRDAIKNNQFVLHLQPILSVRHSMISGYEALLRMVDEKGELVTPINFLTIAERFGLIREIDRWVIRNGIHLITEYQFAK-RGLLINFNLSSK
SFSDSELVFLIKQELAKTNINPRCLVFEITETAIIENMVKAQYFIKSLKAIGCRFALDDFGTGFSSFSHLKHFPIDYLKIDSSFIFDLPYNSASQHLVKA
MVEVACGLGIQTVAEGVDCRNTMQILREFGVNYAQGYYIGRPSKISEIF-----------
>tr|Q1PVH4|Q1PVH4_9BACT Conserved hypothetical response regulator protein OS=Candidatus Kuenenia stuttgartiensis GN=kustc0481 PE=4 SV=1
----------------------------------------------------------------------------ELGE-NIRDILEINGYAAERVSLG
SDLSAQNKHFDALVDIELPDIKGTE---LVGKLASSPS----TQYIYT-GHATLDSTIEAIKQKD--VISYE-------VKPLDIDRMLLTIQQAKIRIQ
TETELHKSERLIE--GYFFFTRDASGVFTYISPSIKNILGYTPEEFYTRYRYLTHLVNND-AAQ-CLARSV-KIKQPPYEIEMYHKNGATRTLQMQEAPV
FDSSKNVISIEGIARDITEIKTSQSQLVFLADHDPLTCLFNRRRFKEELELRLLEAQRNHIKGALLFLDLDNFKYVNDTLGHQHGDELLIKLSCILKERL
RQTDILARLGGDEFAVILPNTEEEQAQHISKQLVELTRCLALDSLNPLHITVSIGIAMFPAHGDTAETLLANADMAMYQAKDEGRDRGCIFSLEHKIHIE
TQYDWKRRIKIALEQNSFALYLQPIINVKTRKITAYEVLLRLTEKNQEVVPPLKFLGTAERFGIIHEIDRWVVVNAIRIIKELKLHE-NGIFLEINLSGK
AFSDNELLSIIKREIGENILRPEMLIFEITETAIIENIAKAQHFIATLKSIGCRFALDDFGSGFSSFNYLKHLPVDYLKIDGSFIQHLSQNSVDQHLVKG
MVEAARGLKKLTIAEFVETKETFQLLKEIGIDYAQGHYFGKPLSVCDALQQFNF------
>tr|D3FDR6|D3FDR6_CONWI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------------MILLLPV--------IALLAGTALLGARRL
HRRSIRRAETIFDTAPIGNAVLDDGDRVVVANPALARIVGFTPEELRGRTLELVHPEDLP-RLSGAIAALRAGRRGLETEIRCLHATGQPVPAAVHAAAL
RDTDGGRSRVLVQVLDITERKRVEAHLQHMADHDPLTGLLNRRRFEQELERHVAHVRRYGPEGAVLVVDVDRFKQVNDAYGHTAGDRVIASVARVLHRRL
RSTDTVARIGGDEFAVLLPKADRAEAEIVARRLVEAVRQADGD-GERTHVTISVGATVLDERSLSAEAAVVDADLAMYDAKDSGGDGFAFFEADVHARSR
ARTTWRDRIVDALAHDRFALVAQPVVDATSGVVVQHELLLRLTGSHGDLIPPAAFLSIAERDGLIVAIDSWVARRAIGLLAELERSG-TATPLEVNVSGR
SLADTDLLAAIAGELRRTGVDPRNLVFEIPETAAVADIQLARAFAQQVRALGCRFAIDDFGAGLGSLYYLKHLPFDMLKLDGELVEQCSRTVADRLVIES
AVNVAHGLGAVAIAEQVGDAETHALLTGLGVDLIQGHHIAMPQPLAVAFGELSP------
>tr|A0A0A5MT92|A0A0A5MT92_AERCA Diguanylate phosphodiesterase OS=Aeromonas caviae GN=MC65_16970 PE=4 SV=1
----------------------------------------------------------------------------PEHHHFLDTMMSHAPVGIGKVDLG
GKILWANPAIEKMLGYSQEELQQLT---VAEINHPDDW----ALYD-LRGERPAFTQEKRYLHRDGTVLWGRVTVTLIRNEQMHPDYLMVVLENIDPIRR
HAEQLKLSHNLS----EAILVCDADSRIISVNPAFEKITGYSEEEACGQR----HDQTFY---------ALERVGIWRGEVWNKRKNGKLYPQQLMISAV
REGGKIS-QYIAIFSDLSQTKLAEQKIAAQANYDNLTGLPNRWLFGRCLARFCER----GERFALMVLDLNNFKAVNNSMDHHVGDALLREVSDRLVSRV
RTEDLVARIGGDEFAFLVPGIVNRRQEVFAKQVIGGFARPFMLANQHLYVTATLGITLCPNDGGDSDELLRNAEQALFVAKRQGRPL-GTYNASMREEVS
QRHQMQHDLAEAIKLGQLTMAYQPIWDNRSGRVAKLEALVRWYHPHWGQVSPADFIPLAEEAGLIQGLGALVLWQSCRDLARLQQSGFPDLQMSINRSTL
EFQTPEANEWL-RVIRHFELDPADIIIEITESLLMETSDQHRVRIDALREAGCKLAIDDFGTGYSALNYLRTFPVDLVKIDRSFVRHIPFNEQDRLLLDG
IINIVHNLGMQVVIEGVETREQLNFLCQKGCAFTQGYLLSRPLPFDDLTEYLSL------
>tr|A0A0E2M0W9|A0A0E2M0W9_9GAMM Diguanylate phosphodiesterase OS=Aeromonas veronii Hm21 GN=M001_05555 PE=4 SV=1
----------------------------------------------------------------------------PDTPHVLQSMLFQAPVGIGKLDLT
GHILWANPAIEKMLGYPLDELLHRS---ISDINHPEDW----ECYE-IRGERSSFTQEKRYFCKGGEILWGRVTVTLIRDEQQQPDYLMVLLENIDPLKR
HAEQLKLSHNLS----EAILVCDADSRIISVNPAFEQITGYSSDEVRGQR----HDQTFY---------ALERVGVWRGEVWNKRKNGKLYPQQLMISTL
REAGKIQ-QYIAIFSDLSQTKVAEQKIATQANYDNLTSLPNRWLFGRCLTRFCER----GERFALMVLDLNNFKAVNNSMDHHAGDALLREVSDRLVSRV
RTEDLVARIGGDEFAFLVPGIVTRRQEVFAKQVIGSFARPFMLANQHLYVTATIGMTLCPVDGSESDELLRNAEQALFAAKRQGRLL-GAYCSSMREEVR
QRHQMQQDLAEAIKLEQLTMAYQPIWDNRSGRVAKLEALVRWYHPHWGQVSPAEFIPLAEEAGLIQGLGALVLWQSCRDLARLQQSGFPDLQMSINRSTM
EFQTPEASEWL-KVIQHFGLDPADIVIEITESLLMESSDQHRVRIDALREAGCKLAIDDFGTGYSALNYLRTFPVDLVKIDRSFVRHIPFNEQDRMLLDG
IINIVHNLGMQVVIEGVETREQLNFLCQKGCAFTQGYLLSRPLAYDDLIDYLAL------
>tr|N9V798|N9V798_9GAMM GGDEF/EAL domain-containing protein OS=Aeromonas diversa 2478-85 GN=G114_14751 PE=4 SV=1
----------------------------------------------------------------------------LQEAPFLSTMLAHSPMGIGRLDSS
GTFLWGNESLLQMLGYNLAQLQALG---VAQLNHPDDD----PPYD-LRGEARTFTQEMRYLRRDGSLKWGRVTVAVIHDSTAVSDSFMFLLEDIDGIKR
DAEQLRLSHNLS----EAILVCDAESRIISVNPAFEQITGYRMEEVLGQR----HEQAFY---------ALARVGVWRGEVWNKRKSGRIYPQQLMISCL
RDEGEIS-QYIGIFSDISQSKLAEQKIVNQANYDSLTGLPNRWLFSRCLTRFCER----GERFALMVLDLNNFKAVNNSMDHHAGDALLREVSDRLVSRV
RTDDLVARIGGDEFAFLVPGVVSQRQELFAKQVMGGFSRPFMLANQHLYVTATLGITLCPIDDNEADILLRNAEQALFEAKRKAKVM-AVYCNSMREEVK
IRHRMQQELAEAIKQGQLSMAYQPIWDNRTGCVTKLEALVRWYHPEWGQVSPADFIPLAEEAGLIQGLGELVLWHSCRDLAQLKQSGFPQLQMSINRSAL
EFQTTEGSEWL-KVIKHFGLSPQDIVIEITETLLMDAGDQHRQRIEALRRAGCQIAIDDFGTGYSALNYLRNFPVDLVKIDRSFVRHIPFNEQDRMLLEG
IINIVHNLGMQVVIEGVETNEQLNFLCNKGCAFTQGYLLSRPLAFDDLCSYLEL------
>tr|H2FZH1|H2FZH1_OCESG MorA OS=Oceanimonas sp. (strain GK1) GN=GU3_02920 PE=4 SV=1
----------------------------------------------------------------------------AQRAVSVLPLFEFFPLPLVRATPD
GVVEWTNRAVQRLSGHHAPAMQGRS---LREFSLGEDW----RLYR-LDEELGMVVMEKHYLHASGQLLLGETQLTLVRDDAGAPWCLMGTLASLRPRNG
HSQGLSLRFEQP----ESVMICDGHSRIEQVSPAFERLTGYREAEVRGRS----HSREFY---------ALSEQGRWQGEVWNRRSNGQAYPERLRISSL
YGPGGGV-HYVAVFSDMGQPDPLDQGVP-PEDKDGLTGLANRASFHQRLARHCRL----SEPFALMILDINNFRLFNNAMNHRVGDRVLQEVAARLRGRL
RSGDYLARIGSDEFALLVPGIVHHRQRIFGRHVLSALARPLHLADQQLYVDATLGGALWPGDEKDAESLLQHAEQALFGAKQKREPL-ALYDDQLNRSQS
RRIRLQHDLTEAIRQGGLRLHYQPIVDTATGRVSKLEALVRWQHPELGAISPMEFVPVAEESGMVQALGDWVLNRACGDLRRLQQAGYR-LDMAINRSSL
EFQSLDGDEWL-SMIERHGLSPRQIIFEITESLFMQGNEHHLERIGALRQAGCRIAIDDFGTGYSALNYLRAFPIDMVKIDKSFIDYLPGNQKDGLLLEG
ILRIIGDLGMKVVIEGMETPAQAAYLSTQPCHFLQGYLIAKPMPLRELLIFLES------
>tr|A0LUT2|A0LUT2_ACIC1 Diguanylate cyclase/phosphodiesterase OS=Acidothermus cellulolyticus (strain ATCC 43068 / 11B) GN=Acel_1420 PE=4 SV=1
----------------------------------------------------------------------------HAIEARFGETYRRVAIGMALLDVA
GRFRAVNDAFAELVGVEADALIGSE---ETTFIRPDRHP-Q--------------RLQVRMCRADGTEIHVIRI---LTAAADEEPFVLGHYIDVTEHNA
RLAALAELGT----------VTDDAGA-ADLVDRARL----LVVQHLGLSE------D-------RAAAVLG-GAGDVLE--LLTAEDRSFV--------
-------RSISSVVCAVHARRRAETARYHLASHDALTGLVNRTTFAARVADAVGQAERGRGHLCVLMVDIDGFKRVNDSLGHLHGDRLLRDIAQRMTAIV
RPTDTVARIGGDEFGVLVTGLAAPNEEAIALRLRDAFRTPFAVDGRSVHLSASIGVATSASRGE-PAELLADADLAMTEAKNTGKGRCVVFRPALRRAAA
QRIALEEDLRAAVEAGAFRLDFQPIVELATGMWVGAEALLRWPHPTRGLVPPLDFIPLAEDSGLVVPLGEWVLRTALQHRVAWTPRLHQDFCVSVNVSVR
QLAEPGFVDVVTDALAASGVPPEVLVLEMTESVFIDEEAGTLAVLRALRDLGVRIALDDFGTGYSALSYLRRFPVDILKLDRSFIAGLLGTAQDQAVTRA
VIGLAQQLDLDLVAEGIETYDQLEILRQLGCRLGQGFLLQKPMPADTLPAHCPS------
>tr|I0G4T4|I0G4T4_9BRAD Uncharacterized protein OS=Bradyrhizobium sp. S23321 GN=S23_25580 PE=4 SV=1
-------------------------------------------------------------------------------AAVLDRAIEIVPAGICVFAPD
LRVVASNEQFASIHGLTRADVE----------QDADG-D-IDAIGEAVVRS------RS--ILELRDGRFISVSRHMAGGGLIEVHITSERLAEIHANET
I--------ELIEKQYVIVAITDVKGGINYVNDNFCAISGYSRDELIGQNH---HPRELF----LASGHVWRGLCNRAKSGR-------LYWVDTVITPQ
LGPDGKPVAYMAIRVDITARKEAEAQLSFAATHDSLTGLLNRCALFDQARIGLGSDVQP-SGLSVHLIDLDGFKRVNDTFGHDVGDDLLKAVALRLRSLA
SDLDLVARLGGDEFAMIRRGGHD---LDLGRQIVETIAEPFEIEGHRLDISASVGIVLCPEQGSNPADLLKKADLALYEVKAAGRDGHRLYQPAMLEAVK
AEKALEADLRRAISAREFELHYQPILDVETRAVHTAEALVRWRHPVEGLIAPDRFIALAERTGLIQPLSEWIIQRACLDAVSWSPG----VQLAVNVSAT
QFKRGNLFDVVMRALLRSGLNPRRLQIEVTETVLLEQQSEQLQTFRRLKAMGATLVLDDFGTGFSSASYLTNFPFDKIKIDKSFIQGLPRRECAA-VIAS
AVVLAKGLGISVTAEGIETESQFEDVRSMGIDFAQGYLFGRPVPYSQFMCAPVI------
>tr|I5C3C0|I5C3C0_9RHIZ PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Nitratireductor aquibiodomus RA22 GN=A33O_05595 PE=4 SV=1
----------------------------------------------------------------------------RDEQKNHQELIEHLSEGIYRSTPD
GRQLSANPALVRLNGYGSEAELLAG---VKDIAFR---------AELTKGVENFISEVY--RHKTRERIWISESARVRDRRTGKALYYEGSVREITET--
------MKRDMFEKLTQLLRRTDGEFSVLYVSKGFRHLLGYDDRT--------VHNDDRA-HYL---------LTPWECEFRIHAADGAEKWLRVAAMP-
-ETTKEGIVWHGYLADVSLRKKNEMEIERLAFYDPLTRLPNRRRLFDQVGRQMTTCRRAGHRGAILFIDLDNFKTLNDTMGHDVGDTFLKQVANRLQAAI
GPQDTVGRIGGDEFVIVLSLSDTTAAIVAANRVLAALRQEFVLGQMIHHTSASVGVLVFDGREKGPEVLMKNADMAMYQAKSLGRNNVALFDPKVLQKER
RRFRLLNDMRSALVDNNLELHYQPQVNA-AGHVVGAEALLRWNHAEHGALSPSDFVGLAEQHGLAELLGRGVIETSVRTLSLWNQNPRADLRMAVNISLK
SLRDPDFLDFLHDRLNAHGLDPQRLTLEMTERVLISDQMQITRRMNELKALGVRLSLDDFGTGYSSIAYLKKLPFDELKIDGSFITDIEGSESNRALVQT
MLDMASTLGLSAVAEHVQTPQQEALLKSSGCAYFQGWLYGRAMTGADFSKFVLE------
>tr|K2MDR4|K2MDR4_9RHIZ Diguanylate cyclase OS=Nitratireductor pacificus pht-3B GN=NA2_03642 PE=4 SV=1
----------------------------------------------------------------------------RDEQQNHRELIDNLSEGIYRSLPD
GRQLSANPALVRLNGFDTEEEMLAH---VTDITFS---------ALLRDGVEDFVSEIY--RYKTRERIWISESARVCDRKTGRPLYYEGSVREITET--
------VKREMFEKLTQLLRHKGGRFSVLYASKGFRDLVEYGDGP--------AHPDDRL-TYI---------MAAWDCEFRLLPMKGKEKWLRVTATP-
-EEIEKGIVWHGYLSDISMRKKNEMKIERLAFYDPLTGLPNRRLLFDHVREQMHQCARENSRGALLFIDLDNFKSLNDTMGHDVGDTFLKQVAERLLAAV
GPGDRVARIGGDEFVIVLSLAGSGAAIVSANRVLSALRQEFQLGQMMHHTSASIGVLVFDGGEKNPEVLMKNADMAMYQAKTSGRNSVALFDPKVLEKEK
QRFALLKDLRSALFENKLDLHYQPQVDT-AGRIIGAEALLRWNHATRGAMAPSDLVALAEQFGLAEPLGRAVVETGVGTLALWKKNPRAELRMAINISLQ
SLRDPDFVDFLQQRLEAHGLDPRLLTLEMTERVMAEDQMQIARRMKELKALGIRLSLDDFGTGYSSIAYLKRLPFDELKIDGSFIADIEKSDNDRALVQT
MLTMAETLGLSVVAEHVQTVQQEQFLRSAGCTFFQGWYYGRAMTREEFGEFVQT------
>tr|K2PP73|K2PP73_9RHIZ PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Nitratireductor indicus C115 GN=NA8A_09474 PE=4 SV=1
----------------------------------------------------------------------------RDEQRNHRELIDNLSEGIYRSLPN
GRQLSANPALVRLNGYESEAEMLQC---VRDIAFK---------ELLRDGVEDFISEIY--RHKTRERIWISESARVTDRRTGKPLYYEGSVREITET--
------VKRQMFEKLTQLMRREDGRFTVLYASRGFRRLLEYGDAP--------AHAEDRL-RYL---------MSSWDCEFRISGMTGTERWLRVTASP-
-EATKDGIVWHGFLADVSARKQSDIKIEKLAFFDPLTNLPNRRLLFERTRQQMRRCAQKGERGALLFIDLDNFKTLNDTMGHDVGDAFLKQVAERLESTV
GPEDTVARIGGDEFVIVLCLAASGLAILAANRVLSALRQEFHLGQMVHHTSASVGVLVFDGNETGPEVIMKNADMAMYQAKSAGRNGVALFDPKVLETER
QRFQLLKDLRTALNGNKLELHYQPQVNA-TGHVVGAEALLRWNHITRGPVAPGDFVALSEQFGLAEPLGRAVIENGLEALARWKHNPRAGLRLSINISIQ
SLRDIEFIDFLQKQLDEYGVEPQLLTLEMTERVLAGDQMQVTRRMKELKGLGIRLSLDDFGTGYSSISYLKKLPFDELKIDGSFITDIEKSETDRALVQT
MLDMASTLGLSAVAEHVQTGQQEAFLRASGCTYFQGWHYAPAMTEEELVGFVMK------
>tr|G6YYF6|G6YYF6_9ALTE PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Marinobacter manganoxydans MnI7-9 GN=KYE_20654 PE=4 SV=1
-------------------------------------------------------------------------------DRSYLIMFDEATQTISITHE-
-ACRSGV---------IPQRDAVQN---VPMA-LPDAEV-LVGLRLEQVRILGFDYLD--------QSRVLDS----------ETEEFVLQVGEVLGASV
HRQILAGRNNSLYRYSQFRMYPDGHVTFPFISEKVENLFGF---------ADLLEDEDKP-SFF---------MTPFETDFRAYKCDGTMAWVEARSVP-
ARLADDSMTWHGYFFDVTDRKQSESEIEKLAFYDPLTGLPNRRLLRDRLAQALTGSNRDHNHGALVFIDLDNFKNINDSAGHLTGDELLVQVGERLKNTV
RDWDTVARLGGDEFVLILKGFPAEPAEKVCEKIRDALNEPYNLNGIEYTGTPSIGITLFYDHETSLEELLSQADMAMFRAKEDGRNCIRFYDSMMQKKVS
ERLALESDLRMAIRRKQLAVHYQVMVNE-KGDPVGAEALLRWHCPGRGMVSPAEFIPLAEETGLIESVGYWVLEDVFSRVASWKKRGGSQLQVSINVSAR
QFHLPSFCSTVMALLRKTGASPRNLKVEITESALAYDLELVEETLRTLRSMGIRISLDDFGTGYSSLGYLKRLSLDELKIDQGFVRDILDDPNDAAIAET
ILALASALKLSAVAEGVETKGQLERLVGMGCNRFQGYHFSRPLPALEFEKLIEQ------
>tr|S1GQR8|S1GQR8_ECOLX PAS domain S-box protein OS=Escherichia coli KTE102 GN=A1WO_03589 PE=4 SV=1
----------------------------------------------------------------------------KRTEQVNQQLMEAGGIGIWEWELK
PNIFSWDKRMFELYEIPPHIKPNWQ---VWYECVLEDR--------RSLQSRSPFKLEFRIAVK---IRHIRALANRELNKEGEVERLLGINMDMTEVKQ
LNEALFQKEITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPLTVL-------------ENIYSARSAIEQDVVLHCRSGGSYDVHYSITPL
STLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSTGHAAGDALLREQASLMLSML
RSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNYHFIWEGRVHRVGASAGITLIDD-NHQAAEVMSQADIACYASKNGGRGRVTVYEPQQAAAER
AVMSLDEQ-WRMIKENQLMMLAHGVASP--EARNLWLISLKLWSCEGEIIDEQTFRRSFSDPALSHALDRRVFHDFFQQAAKAVAS--KGLSIALPLSVA
GLSSTTLVNELLEQLENSPLPPRLLHLIIPADAILDHA----ESVQKLRLAGCRIVFSQVGRDLQIFNSLKVNMADYLLLDGELCANVQGNLMDEMLITI
IQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLIYGDVIADAQPLDLLVNSSYF------
>tr|B0C6M6|B0C6M6_ACAM1 PAS sensor diguanylate cyclase/phophodiesterase, putative OS=Acaryochloris marina (strain MBIC 11017) GN=AM1_1416 PE=4 SV=1
----------------------------------------------------------------------------RQYE----TIF----AGSYLVDTC
YEYLAANPQYTEKFSGQSAKVHGQP---FFQEIIKDLDH-WVPSLD----EARYFDIEYVPF----------------RNQQEQIIGAAISARDITVLKD
TEEALRESQDFAAIGADLFWETDAELRFTYLSEQHCSLTGSPIEAWIGKSCDFY---D-------HLNQTLDALEPFDIEIECQHLDGNARVLRSIGKPV
FSPQGVFCGYRGIGRDITEAHSLSQQLTHQATHDSLTGLVNRREFEHQLGQIIEEKQSNPIQHALCFLDLDQFKIVNDTVGHLAGDALLKQVADLLQAHI
RQTDILSRLGGDEFGLLLKNCSLEKARIVTENLISELSFRFIWEGQLFKIGASIGIVPITA-DDNLTLLFAKADVACYSAKDRGRNRVHLYHAQAQGVQH
SELMQVATIRKALEESRFRLYYQPIVPLTKI-PVCYEILLRLQDTDGKILSPNSFLPAAERYGLMLEIDKWVIENVLIKYGAYFQSQ-ENTRISINLSGS
SLDDDALLDFIQTQLNKTQLEPHKICFEITETVAISNFKQAIQCIEKIKEFGCHFALDDFGSGFSSFSYLKRFPIDYLKIDGSLVRDMVEDATHQVMVSA
INQICRAMHIKTIAEFVENGDTIVALEQIGVDYLQGYAMGKPQPLPTK------------
>tr|Q2YC85|Q2YC85_NITMU Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849) GN=N
------------------------------------------------------------------------------------GLL----DAIVIVNRN
GEIVLVNSQTEKLFDYQREQLLGKK---MEMLIPPRYRM-GIGLELY-LRDGTEFPVEISLSPLTET-----------------KEIQTQLRRDLTEREI
AEKALFEKEVTLSCIGDAVITTDTEGSVTYLNPVAEAMAGCSSDDAKGLPLDVF--SS-------PAERVLRNVSLNSH-ALLIRRDGQTFPIEDSAAPI
RDQNGSIIGVVLVFRDVSHAQKMAMEMRYQATHDALTGLINRHEFERRLKQVLER-DKGADEHTLLYLDLDQFKIVNDTCGHLAGDELLKQLTSLLQAKL
RKDDTLARLGGDEFGLLLERCPRGSAFRVAEVLRQTVQFRFVWEERIFSLGISIGLATFSG-GQTFSDVLRMADTACFLAKDKGRNRVQLYASDDKNLRR
GEMGWVERLHKALDKQRFVLYSQKILPLSS--TSHYEILLRMKGENGELVPPMAFIPAAERYGLMPQLDRWVITNAFAQYASHPSRG-IKDTCTINLSGA
SICDEHLYDFVVDQFKQSQIDPAGICFEITETVAIANLTQAATLIRKLKELGCRFSLDDFGSGMSSFTYLKHLLVDYLKIDGAFIKGMLSDPIDHAMVEA
INHIGHVMKIQTIAEWVEEESFLEALRKIGVDYAQGYAIEEPRPAITLCH----------
>tr|C6WVK9|C6WVK9_METML Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Methylotenera mobilis (strain JLW8 / ATCC BAA-1282 / 
--------------------------------------------------------------------KQKLMSELDYANKRINQIVNLSPAVIYTLKPN
GHSDFISENIYQITGYAKDEWLKDN-FWL-DHIHTEDLAALD-SKKILFETG-SLNHQYRFMHANGGYIWIEDQLTLTRDNNGKPLEIVGAWLDITDRLS
AEEKLRLNAKVFESSRDGIVITDKNNKIISVNNAFTTITGYEAKEVVGKNPHMLASEKLEESFYSAMWDSIGVMGYWQGEVINQRKNGEIYTQWLSISTI
KDADGKISQHIGIISDISERKVAEERIQFLSNFDPLTNLPNKNLLNDRTKLALATAKRLKTAVTLMFVDLDRFKFINESLGPSIGDQVVKELAERFVAYM
RPEDTVCRQGGDEFILLLPNTDAEGAAHVAKKLLDIVAQPFNFHGQKIVLTASIGISAYPQDGESFEQLAQSADAALYRAKYEGRNNFQFFARQMHEQAH
DILLLESELRSAIEHEEFLLYYQPQYDSKTSKIIGLEALIRWQHPEKGLVSPAVFIPIAEESGLIAEIGDWVLRTAVKQLASWQEAGLGAVPVAVNLSVV
QFHQDTLYGSVCQILRDTKVDPSMLELELTEGIAMEDSERTLNVLNQLNSLGVRLSIDDFGTGYSSLSYLKKFKIDKLKIDQSFVRGIGSHPQDAAIITA
IISMAKSLSFKTIAEGVETLEQLNFLIANSCDEIQGYYFSKPLPSTEVTKLLAN------
>tr|G4SUW0|G4SUW0_META2 Putative Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Methylomicrobium alcaliphilum (strain DSM 19
--------------------------------------------------------------------RLKLQQELSSYYQHITHIIDVNPAIIYALKAQ
NVIDFISVTARNMTGYPLEEWHAPG-FWI-SHVHPNDRQLLQ-AQQRLLKQG-RINYQYRFLHADGHYCWIHDQSILHRDNTGQPLEIIGTWLDITEQKQ
AEQQLRLHAQVFQSSQEGIIITDAENNIISANPTYIELSGYTEEEALGKNPRLISSGLQDKSFYENIWQEIHQRGHWQGEVINRRKNGDLYPQWLSITVI
RNPEGRITHHIGIMSDLTEHKAAEERIRFLSHFDTLTQLPNRSLLRDRTELAITGAKRANARIALMFIDLDRFKIINDSLGPTIGDRLLVAIADRLTDHL
HPNDTLCRQGGDEFILLLPNTDAESVAHVAQTILQLIAQPFVIEDHRLTLTASIGIAEFPQDGNNFEQLSQAADAALFRAKGTGRNNFQFFTRQLHEQAN
RLLQIENELHLALERNELLLYYQPQVDAKTSTIIGCEALVRWQHPEKGMIPPGQFIPIAEESGLILKIDDWVLKTAIRQNVSWQAEGLPVVPVSVNLSGL
QFQQASLYETVAQLLQMNRLDPAMLELELTEGIAMDNSERTISLLRRFHQLGISLSIDDFGTGYSSLAYLKRFQIDKLKIDQSFVRELGRDPEDEAIVSA
IIGMAKSLGFKTIAEGVETRDQLEFLLNNQCDQIQGYYFSKPLPANEFAERLRS------
>tr|D7DIJ0|D7DIJ0_METV0 Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Methylotenera versatilis (strain 301) GN=M301_1495 PE
--------------------------------------------------------------------RRLAQDKLQLAQLEYRDLYEFAPIGMLGVKRG
QSQFVIDE--------EKSRWQKLG-RYF-SAHSPSKHLLVPPAISEAYDTD-RSQGRQFELTLPGGKFWFELSVAKKPKVAGEDIRFILLSRDVTERKQ
SELEFRIAATAFE-SQEGMMVTDVNKIILRVNKAFTKISGYTAEEAVGQTPRLVSSGHHHEDFYASMWQNIDASGYWEGEVWNRRKNGEVYPQHLTITAV
MGDNGIVTNYVATFTDVTLRNAAEAEINHLAFYDVLTRLPNRRLLIDRLNHALSAGARLGWGGALLFLDLDHFKTLNDTLGHDVGDLLLRQVADRLTDCV
REGDTVARLGGDEFVVMLEDLSAGQAETIANKILISISQPYQLGASAYQTTASIGVVLFSENEHSQDVLLKHADIAMYQAKKMGRNTLCFFDPNMQEAIN
MRAALEVDLRKALDNNQFELYYQVQVDRL-GKALGAEALIRWIHPERGLVSPLEFIPLAEETGLILPIGQWVLETACAQLKAWQTKRQQALTLSINVSAK
QFYQNTFAKQVQAAVKHSGINPIRLKLELTESIMLENIEATITKMMELKNIGVNFSLDDFGTGYSSLQYLKLLPLYQLKIDRSFVREIAIDTSDQAIVRT
VIAMAETLNLDVIAEGVETDEQRELLMNCGCNAYQGFLFGRPMPIAQFNLALKP------
>tr|D7A477|D7A477_STAND Diguanylate cyclase/phosphodiesterase OS=Starkeya novella (strain ATCC 8093 / DSM 506 / CCM 1077 / IAM 12100 / NBRC 12443 / NCI
------------------------------------------------------------------LELFPFLEALGDLQGLTFYALASVPSGEWRWAPD
PEKYV-AQRL----------------------------------QRHAEADGEPFLIP------LENGGWVQARERRTPDGW-----TVSTWSDVSGLKA
AE-------TRLDDAIDGIPALDAEDRIELVNSGMRRIFAGADALEAGQRLPEVLDGAEAKGFFARLARIALRDGGWILASHRRLPNGGT----------
----------VGIWTDLTTQKKREAEIAQQARNDMLTGLPNRFALEERLDQLLRDGETG--NLWVGVIDVDHFKGINDAVGHAAADDLLREVGRFLRGHL
RGDDMLARIGADEFAMVLTELDEEVMG-IANRLHAATHSHVFRIGHRFSLTVSVGLSLAQPDRHSAASLLAAADTACRVAKEAGRDRVQIYDLGKVSTTQ
QRLGWAERIRLGLELNRFTLHLQAIVD-EKHRILGYEALIRLRNEDGAYCSPAQFLPAARRLGLMGRIDSWVCRQCVGYAMQLIATGSD-QYVSMNLGVH
TLANIAFQSRLLDLVRTNPGVEQALRIEITETDEIYDAPQVSAFLAEMRELGMHVSLDDFGNGYNSFEALKQLPVDGIKIDWTVTRDLLHDPIDEAQIRA
AVSIAHSLGLELVIEGVEEEAQLVRLKELGATLFQGFYFHRPIDAADIFEALPL------
>tr|F4G3P9|F4G3P9_ALIDK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K
------------------------------------------------------------------GGINAARAALARSENILRLALDGSGSGMWDWDLA
QRRITGRYRV----------------------------------QRA-IAAGGSFDETARLQRFDGSYCWFQARGQCHRDAQGRPERFSGILADLTDLRT
AEERQRLASTVLDNAVEGVVVADAHARILSINPVVTRVLGYTEEELLGRNPRVFQSGRHDKAFYETMWEAVRRTGHWQGEIWNRRKNGEIFPERMSLSAV
RDAQGAVTHYVCMFSDISQEKAQHQRLEFLSHRDSLTGLPNRAWFVEQLGQALCQAQVHGEQMAVLLLNLDRFKDVNDSYGHAVGDEVLRHITAQVCMSL
RPGDLVGRMAGDEIAVLARNLRHDGAAAVAQYMIAAASKPWRTPGIEVVAGVSVGISMFPEHARTAEQLLQGAHSAVYGAKARGRGAHCFFDESMIQAAR
ERLEIEARLRSALAQGHLRLYYQPQVDIATGRIVGAEALLRWLDPEEGVISPARFISVAETSGVIGPLGRWVMQEACSQGQRWRAAGLPGIRLAVNVSPY
QFQLTDVAACAAQALEDSGLPPHCLELELTESALAERPEAMRQVLQRLQALGVRIAVDDFGTGYSSLAHLKRFPIDALKIDQGFIRDIPSSADDMAISAT
IIAMGRSLGLTVLAEGVETPEQLAFLRARGCDSYQGYLCSRPVPAEQFGALLQA------
>tr|A0A0A1VI82|A0A0A1VI82_9BURK Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Acidovorax sp. MR-S7 GN=AVS7_0
------------------------------------------------------------------GEAEAARAALERSETRLRLALDGSGSGMWDWDMA
QSQATYRYDV----------------------------------LRT-LCADRPFQETARLQCFDGTYRWFHARGMRHMGADGRPERFSGILTDLTAERQ
AQQRQRLAATVVDNTIEGVVVTDAHSRILSVNAAFTRLMGYTEAELLGKTPRVFKSGRHDRAFYEALWESLRGTGHWRGEIWNRRKNGEIFPERMSLSAV
HDAVGQVTHYVCMFSDISEEKAQRERLEFLAHCDPLTGIANRAHFGELLAEAVREAGDRGERLAVLQLNLDRFKDVNGSYGHAVGDEVLKHIARQMQEAL
RPGDLLGRMAGDELAVLARALQREDAGAYARELIAAVARPWRSPGLAVVASASVGICLFPDHMRTAQTLQQGAHAAVYGAKALGRGAWCFFDEGMTQAAH
ERLAMEARLRMALRPGQLQVYYQPQVDIASGRIVGAEALVRWFEPGSGAVSPAQFIPVAESSGLIGPLGEWVLAQVCLQGRQWRAEGLPPLTLAVNISQH
QFHLTDLSGSVAAALEVSGYPPQALELEITESALAARPEEARQVLQRLRAQGLRIAVDDFGTGYSSLAHLKRFPIDVLKIDQGFIRDIPRSADDMAISAA
IIAMGRSLGLSVLAEGVETAEQLAFLRERGCDAFQGYLCSRPLPPQEFAALLRA------
>tr|D0IUW1|D0IUW1_COMT2 Diguanylate cyclase/phosphodiesterase with OS=Comamonas testosteroni (strain CNB-2) GN=CtCNB1_4372 PE=4 SV=1
------------------------------------------------------------------SEMVSARNAMMRSETMLRLALEGSGNGVWEWDAL
EQRLNFRYQA----------------------------------EQA-LEQGSMLVLTARLLCFDGLYRWFRARGQAYKDESGRLIRISGLLSDQTASRE
ADERSRLASTVVDNTIEGVVVTDAHSRILSVNHAFTKLLGFSEAEMLGKTPRMFKSGRHDKAFYDAMWASMHATGHWQGEIWNRRKNGEVFPERMSLSAV
KDANDKVTHYVCMFTDISAEKAREQQLEFLAHRDTLTGLPNRSQFTRMLGEAVELSQSTNRRMAVLLFNIDRFKDVNDSYGHSIGDEVLRHVSVQMQGAL
RHGDIIGRLAGDEICVVAQSICGDSAVDVAERLMAAAGQPWTTPGLSVVVSVSAGICLYPDHALTADDLLQGAHAAVYGAKARGSNAWCFFHENMTQAAR
ERLALEARLRRALELGHMRLYYQPQIELATGRLVGAEALLRWLDPEEGLISPARFIPVAENSGVIGPLGLWVLGEACRQGQQWRAAGLPDLAIAVNVSLH
QFLLTDIAGATAEALNKSGFPASLLELEITESALAEKPEEALAVLNRLRELGLRLAIDDFGTGYSSLAHLKRFPLDLLKIDQGFIRDIPHSADDMTISSS
VIALGHAMGLKVLAEGVETQEQLSFLQQKGCDYFQGYFCSRPLPAEDFTRLLEK------
>tr|A0A014NKM2|A0A014NKM2_9BURK Diguanylate phosphodiesterase OS=Comamonas aquatica DA1877 GN=AX13_02620 PE=4 SV=1
----------------------------------------------------------------------ADRQALEASEEKLRLALDGSGSGMWDWDMA
QRRHTFRYEA----------------------------------QAT-LEQGVPFVVTARVLCFDGAYRWFEARGTRHLDDRGQPVRFSGIITDKTQQRA
EEDRLRLAASVVENTAEGIVVTDANSHILSVNPAFSRLLGYEAAELIGKRPSTFKSGLHDKAFYDEMWSSLHRSGHWRGEIWNKRKNGEIFPERMSLNAV
RDPQGHVSHYVCMFTDISEEKQRERQLEHLAHRDALTGLANRNWFVQELTRCVHHAVETRERMAVILLNLDRFKDVNDSYGHAVGDEVLRHIARQVQSAL
RPGDLIARMAGDEIVVLTRHLKHKEASDIAERLIHAAAQPWKSPGFAVVVSGSAGICCYPEHAQDAALLVQGAHAAVYGAKDGGSNQWCFFNEDMTQAAR
ERIALESRLRNAVAQGHLQLFYQPQIDIATGGLIGCEALVRWFDPVDGMISPARFIPVAESTGLIGPLGEWVLGEACRQAQAWSSQGLPDISIAVNLSLH
QFLLTDIVGCTRQALARSGLPAGRLELEITESALAARPDEALTVLRGLKDLGLRLAIDDFGTGYSSLAHLKRFPIDLLKIDQSFIRDIPQSADDMAISHA
VIAMGKSMGMEVLAEGVETAAQLEFLRQHGCHFYQGYFCSRPLPVGEFTVLLEG------
>tr|G0A1S2|G0A1S2_METMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomonas methanica (strain MC09) GN=Metme_2925 PE=4 SV=1
------------------------------------------------------------------SARKDAELALQQSETLFQTLARLAPVGIFKTDAS
G----KNQRW----------------------------------ARS-IQTQIPFYSQYRFQHKNGPLHWVVGRAEAEYDGNNRLLGFIGTITDISEIKR
NEEHLRLAAAVFETTREGVMITDANRNIQRVNRAFTQITGYSQFETLGKTSNLLRSGRHSDAFYEAMWDEIIHTGHWQGEIWNRRKNGEIYPELLSISTV
KDSNGEICHYVGVFADISKLKASEQELEFLAHHDPLTKLPNRVLLMSRLQHSISQAQRQHSQLAVVMLDLDRFKDVNDSFGHLAGDDLLQSVARRLTARL
RAADTVCRLGGDEFVVLLENIAHETAARITTDIIAAINEPWHLSGNAVRVGASIGIALYPEHGEAPAELLQHADTALYQAKNEGRNCFKYFSEELTRAAR
ERIGIEFRLRQAIENNEFRVFYQPQLAIGSGEIIGAEALIRWQTAGG-LIPPLKFIPIAEETGLISNIGNWVLKEACRQGKEWLDAGLPRIRIAVNLSTH
QFLHSDICAIVANTLAETGFPADYLELELTESALMKREKEAIDILNRLHELGTHLAIDDFGTGYSSLAYLKSFPLDILKIDKSFIDDIPMQNDDMEITAT
IIAMAKTLRMQVIAEGVETPAQMAFLSSRNCDFYQGYFASKPLPADEFAAFLRQ------
>tr|A0A0A6R6G6|A0A0A6R6G6_9GAMM Diguanylate cyclase OS=Methylomonas denitrificans GN=JT25_00515 PE=4 SV=1
------------------------------------------------------------------TARKHAEIALQESELLFHTLSKIAPVGIFRTNEK
G----ENHRW----------------------------------QRC-VSALQPFNMQYRFQLANGSVHWVVGRAEPELDEAGGLCGYVGTITDISDIKA
NEERLGQAAAVFESTREGVMITDARRRITMVNKAFTDITGYDNQDVIGNSPGIMSSGRHNADFYREMWANINATDHWQGEIWNRRKCGEVYPELLSISTV
RDGKGEISNYVGVFADISKLKASEMELEFLAHHDPLTKLPNRMLFLSRLQHNIEKARRQANKMAVLMLDLDRFKDVNDSFGHLAGDDLLQMVAERLTTRL
RTSDTICRLGGDEFVVLLEEVNQETVAHVATQIINALNQTWQLPGHEVRIGVSVGIAMFPEHGASPDELIQQADTALYQAKNEGRNRFKYFSEDLTRAAR
ERIDIEIRLRQAIEQGELRVFFQPQFCIHNGAIVGAEALVRWQTASG-LIPPIRFIPIAEETGLITTIGNWVLRETCRHGQRWREAGFPPLRLAVNLSPQ
QFLHSDISDVVAKVLEETGFPAEYLELELTESALMKREKEAIEILHKLHALGVHLAIDDFGTGYSSLAYLKLFPLDVLKIDKSFIEDIPKHTDDMEITAT
IIAMAKTLRMRVVAEGVETAEQLAFLKSRQCDLYQGYLASKPLPIAEFEKFLTD------
>tr|F1VW05|F1VW05_9BURK EAL/GGDEF/PAS/PAC-domain containing protein OS=Oxalobacteraceae bacterium IMCC9480 GN=IMCC9480_921 PE=4 SV=1
--------------------------------------------------------------------FRQPPVADAPSEMITLLPALTAMTATWLWSFR
AW---HRYQ-------------------------------------------------------------------------------------------
VRDSY-RMA--TECSIDGITINDRHGKISDCNNRSGLFYGVDAKTLIGMRLSEVTAAPYFPETMKAMR-SALQTGYLEDELRGRAS-HPNEPQWMHRQ--
--LARTGTGIAMTLRDISKKKIHERELWRMANEDGLTELPNRNWLTGFLPEAIRQARLAGRLVAVLFIDLDDFKDVNDTLGHSAGDELLRVAARRLQSIL
RPGDHVARLGGDEFTVILSSIADHAGALVAQRIIEAFATPFELGGTD-TVGISIGISLFPDDGHDASDLLKNADIAMYCAKTAGKNRARFYESRMSAALT
ARVDIERALQCAIEHNEFVLFYQPRINAASGQLLGLEALVRWQHPERGMVPPLEFIAIAEETGMILALGELVIEQVCRQIASWRDAGLPVVPVSVNVSPR
QFDKGNIKILFATYMLRHRIDAGLVEIEITESSMMGEEEELSHELRTIRALGIKLLLDDFGTGYSSLSQLQRLAMDVLKVDRAFTSELGKTTEGEVFFRA
IVSMAHALGMTVVAEGVETVEQLRILQELDCDEIQGYLISRPVPANEIPALLLQ------
>tr|A0A0A6DXL8|A0A0A6DXL8_9BURK Diguanylate cyclase OS=Janthinobacterium lividum GN=NC77_05210 PE=4 SV=1
----------------------------------------------------------------------AAQGALLLMGDNFRQLYQKSADAILLL-RD
EHIAEANPAAIALFQCEDRQRLGRR---LSDFS-PLRQPDELTQLAAQAHADGNCRFDWRYQTCSGELFWGEVLLTSV--TLDHTYLFYAVIRDISSRKL
AERALYLSMQVIEHASVAIVVMDPQQRVVSMNPAYSEISGYSLDDMLGKPFVLHGVEPDAPAFFDHVWDEVDANGYWQGDIMGQRKADGRYPAWLSLTAI
RDSQGQLSNYLAILSDISERKKNEEHTRHLAEHDFLTDLPNRVLLLDRLSLALAAARRKLSMLAILYLDLDHFKHINDSMGHHVGDLLLKEVARRLVRCV
RGVDTVSRHGGDEFVIILAEVGGDQVAHVASSLLHAVTQVYQLGEYELHVSTSIGVAIFPSDGDGIDTLVHNADIAMYHAKESGRNNFQFFNAEMNAQIV
ERASLEQGLREALGRDEFVLEFQPALDVASGQIVGAEALLRWRHPQLGVLPPERFIAVAEECGLMVSIGNWVLRHACLRARAWHDAGHAW-HVAVNLSPA
QCLHNNLLLGVQEALTASGLPAGCLELEVTESLLMKGGARLAGVLAQLRALGARLAIDDFGTGYSRLANLRHYPVDKLKIDPSFLPAAANGESDTVVAAT
IIAMARALQLTVIAEGVETAQQLAYLRGQGCQQYQGRYASAQVEGSALARLL--------
>tr|F1W276|F1W276_9BURK EAL/GGDEF/PAS/PAC-domain containing protein OS=Oxalobacteraceae bacterium IMCC9480 GN=IMCC9480_418 PE=4 SV=1
------------------------------------------------------------------------EQALLTVGANFRTLFDNSSDAIMLL-ED
NHFLDVNPAALALFGYASKTDMGRA---SAEIS-PPQQPDLARQMQDLVQQKGNHRYDWQYLSNQGKPFWTEVLSTDI--PAAGQRLQYVVVRDISTRKA
AEMSLHLAARVFENSQEGIMIADEHRRVISINRALTDITGYTADEVIGNPPQILCSGTHDKALFQAILESVLKHDHWQGELWGRHRDGRGYPLWLSVTAV
RDSHHAVLNYIGIVTDISDRKASEEQMRHLAEHDFLTGLPNRVLLLDRLQQAIAVAERSRTRLAVLFLDLDRFKNINDSFGHHVGDKLLQTVAERLKKCV
RGIDTVSRLGGDEFVIMLVDTGSEPIAHVAGKILQAIGTPYSIEGCEFSVTTCIGVSTYPADGTDMDVLIKSADTAMYHAKSKGSNRYQFFNNDMNTRVV
ERIVLEHSLRSALKSSEFILEYQPQIHIASNRLIGAEALIRWRHPTLGRMMPDRFITVAEECGLIVPIGDWALRQACLQARAWQDQGLEL-VMAVNLSVA
QFHQQNLVRSVTDALQAARLEPQWLQLEITESIMMEEAKGAIDMLRSLRDLGIRLAIDDFGTGFSSLSYLKRIPIDKLKIDQSFVRDITLDPEDAAIINA
IIVMAKSLNLTVIAEGVETLEQFRFLEAHGCDEYQGFLASKVLSVADFSARY--------
>tr|W6LWK1|W6LWK1_9GAMM Putative Diguanylate cyclase OS=Candidatus Contendobacter odensis Run_B_J11 GN=BN874_610031 PE=4 SV=1
------------------------------------------------------------------------EAALRASEVKYRGVFATIGDSLLLVDRD
GRIFDVNPAACKLYGYSREELLLRD----RDLA-VDAATH------ELLSTPSTRRVDHLHRRKDGTVFHADIYLRRF--TYQGHKVTVEAVRDMTPQKQ
AEQKILRLSHCYRHAEPCQIVADLEQQIATIGFVDSETGGFQPAALFDDPSIPEIWEPTGMAFRQGSFPSDPNAQGWRQGVMGI-HAGAAFPLRRNYALL
NNLAGEISFALDLFDREAQRKSAEARIHQMATHDPLTGLPNRTLLLDRLAQALHHAQRKRQHVGVLFLDLDHFKTINDSLGHEVGDQLLQQVTERLRHCI
RQEDTLARQGGDEFILVLPDIIDAAVGQVADHLLHALHEPFMLNDQRLHIGASIGVSIYPLDATDPPTLIRFADSAMYQAKEAGRASYAFFTVELNHRVS
ERFALSNELRHALEADEFVLHYQPQFELATGRLIGAEALIRWQHPERGLVPPIKFIPVAEETGLINAIGEWTLRVACTQNRCWQDAGLPAIPIAVNLSAK
QWLQPHLEDQVIQALETVGLAPELLELEITESLLMRDTEKMIGTMRRLQTRGVKFAVDDFGIGYSSLSYLKRFPINRLKIDQSFVRDIPADPDDTAITTA
IIQMGKSLRLTVVAEGVETLEQLRFLREQGCDAAQGYHFSKPVPAAEFARCC--------
>tr|I4D1V3|I4D1V3_DESAJ PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Desulfosporosinus acidiphilus (strain DSM 22704 / JCM
------------------------------------------------------------------------QNELLRQEELYRDMFENMSSAVVIFEIN
NGENALNQTAERVENIPRQ-QGGAL---ITELF-PMIKELVWDLVLEVYRTGEKRHFPAVYYNNPRCSGWSEGVIYKL--ATGNI---VFLYDDVTHRKL
NEKALWQEKERA-----GVITTDVLGNITYLNPVAETITGWNGQE----QVFDICSESAETALVQPVVITVTNP-----AMIRQRHSQQYFHIEV---PM
RDREETVVGAVLVFRDVTEKRTLLYRLTHQANHDSLTDLPNRLLFKDRLQLAILQACRRQEKIAVFFVNMDDFKLINDTYGHEVGDTILCQIAERLQKAL
RPDDTVARQGGDEFLILLPELSSQQAAQIARKLLKALNSPFQIGDQETYISASLGIALYPVDGEEPEVLIQHADVAMYQVKAEGRNHYHFYTEALNERLS
ERLKLQNEMRRALKNNEFFLEYQPQYCLKNGRICGIEALVRWRHQERGILYPGKFIPLAEENGLILPLGEWVLRSACTQNKLWQDLGYPPVSIAVNLSPR
QFRQKDLIGKITRILDDTGLEPHWLELEITESLSMEDVELSSEILRKMKSMGIRLSIDDFGTGFSSLSYLSRFSLDTLKIDRSFISSLSEYADKQAIVLT
IIQLAKNLGLKVIAEGVESPDQLDFLSKKDCDVVQGFLLAKPIPVGDIRPYF--------
>tr|Q1JZB1|Q1JZB1_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_1518 PE=4 SV=1
------------------------------------------------------------------RAIQERETELSRERDRFQALFDNVNDAVFMCDEE
QNFVEVNGVASDLLGYSRAEFLQMT---PMDIDTIDSLSLRDHIGSISMESDQPGLIETTMVTKQGRKMPFEINLQPLRLDDQ--QMLVCVARNITDRKQ
AQRALNALSSCFEKILRELCLYFEDGALIGIPNGFLGLVGSPCEKVLRNEVCFYPSGVRELFPQDQMGIEQKVVGVLNGFSRQRMHLPPDAREILSIVAA
RAAT-ELER----LKADEALAEHRKQLSYLAFHDPLTQLPNRLRFTEVLEAAVGDAEGHGRYLSLLFIDLDRFKNINDSLGHSIGDKLLQAVARRTGSLI
DSADVLARLGGDEFAILLFNCVTVVGADTAQRVIDALSQPFQIDDYSLHVSASIGITVAPVDAREPDELIKCADIAMFKAKDAGRNTYKFYERSMNLKTH
ELLLLENDLRHALSRDQLELYYQPQLDLQSNCIVGFEALLRWNHPERGLVSPLEFIPLAEETGLIVSMGEWILRSACRQIRTWNEEHGRQLRVAVNISAR
QFHHYDLVHCVEKVLEQTGVPTEWLELEITESLLMYDIQSSIETMMRLKKLGVRLAIDDFGTGYSSLSYLKKFPICSLKIDKSFVDDLLTDASDAAIAES
TLALASKMDLMVVAEGIEQQEQLDYLQQRGCQFGQGYLISRPLPVAQCTQFCRER-----
>tr|A0A011PZ10|A0A011PZ10_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-92 GN=gmr_4 PE=4 SV=1
------------------------------------------------------------------NAILEREAA-------------------------
-RLVEVNDAWLALLGYERAEVIGQP---ISAFLAR-YWPVL----------QEPTDVLLDLRCKDGKSITVQASGRIHRTPQGG-ACSHCILTDISERQR
RDEAQQRSQSAFEALADRLCVFNDPRMLLGVGNAGQD------------------IVNQRRAEQATVFSAERIVGLWQGEVWQRRKNGEVFPAWLTVTVV
KSADGTVTHYTGSFDDISERKQSEAHIHFLAHHDVLTRLPNRTLLEDRIRQALAKSRREATHTAVLFLDLDRFKLINDTLGHDVGDQLLARVAERLSKVL
RETETVARLGGDEFIIVIPDVADERVARVARKVLAAVAAPQLVGKRPLHVTPSIGISIYPEDGEDVPSLLRNADTAMYHAKERGRNNFQFFTQVMNQAVI
ERVSIENDLRTAIERGEFELFYQPQVDRRSGETTGMEALIRWHHPQLGLVAPDRFIPVAEETGLIIPIGEWVLREACQQAKRWHGAGQNGLRISVNLSAR
QLQQGDLCERIAAILSEANLPPLTLELELTESLLMNDPLAAVQLLQGLAALGVRLAIDDFGTGYSSLAYLKRFPVSRLKIDRSFVRDLSTDANDAAIVHA
VVAMAKSLKMEVIAEGVETVEQLNFLAAHGCFAVQGFLFSRPRPAAEFTRFHFTL-----
>tr|A0A011QLU7|A0A011QLU7_9PROT Bacteriophytochrome cph2 OS=Candidatus Accumulibacter sp. BA-93 GN=cph2_4 PE=4 SV=1
------------------------------------------------------------------NAIVEREAA-------------------------
-RFVEVNDAWLSLLGYRRDEVVGRE---IGDFLAA-SLAML----------VEPTFVLLDFRRKDETTIRVQVSGRIHQTPRGG-ARTHCILIDVSERQR
RDEARRRSRSEFEGLADPLCLFDAQRMLLGVGNAGQD------------------IVNQRRAEEATVFSAERIVGLWQGEVWQQRKNGEVFPAWLTVTAV
ISPAGTVTHYTGSFDDISERKQSEAHIHFLAHHDALTRLPNRLLLEDRIRQALAKSRREGTHTAVLFLDLDRFKLINDTLGHDTGDQLLARVAERLGKVL
RETETVARLGGDEFIIVIPDVADESVARVAQKVLEIVAAPQLIGKRPLQVTPSIGISLYPEDGEDVPSLLRNADTAMYHAKEHGRNNFQFFTGDMNRAVI
ERVSIENDLRTAIEQREFELFYQPQVDSRSGETTGMEALVRWRHPRLGLVAPDRFIPIAEETGLIVPLGEWVLREACRQAKRWHDAGHHALRMSVNLSAR
QLQQGDLGKQLAAILAESGLQPRTLELELTESLLMDDPMSAVKLLHALAALGVRIAIDDFGTGYSSLAYLKRFPVSRLKIDRSFVRDLSTDANDAAIVHA
VVAMAKSLRMEVIAEGVETVEQLRFLAAHGCFEAQGFLFSRPCPAAELTSFRFVL-----
>tr|A0A011NN58|A0A011NN58_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-12 GN=gmr_10 PE=4 SV=1
------------------------------------------------------------------NAILEREAA-------------------------
-RLAAVNDAWRSLLGYDSAEVVGRP---LSDFLEG-SKERL----------AEPAFVGCDFHDKDGRTIPVLISGRIHRGADGQ-ARTHCILTDIRERLR
SEEARQRARSEFEAISERLCLYQDQRMMLGVGNASQD------------------IVNRHRTEQATVFSAQRIIGTWRGEIWNRRRNGEIFPAWLTITAV
IGSEGKVTHYIGSFHDITERKRSQDHIHFLAHHDALTRLPNRRLLDERIREAIDRSRREQLHAAVLFIDLDRFKLINDTLGHDVGDRLLSRVAEILSSVL
DEHETVARLGGDEFVIVVPELADSRTAQLANRLIEVVSAPQLIDERPFQVTPSIGISIYPDDGEDAPTLLRNADTAMYHAKERGRNNFQFFTAAMNEALR
ERVSIEHELRLAIERDEFELVYQPQVDSRDGRVEGCEALLRWHHPQLGLVPPGRFIAIAEETGLIVPIGAWVLQQACRQLRAWHDAGHAGMRIGFNLSPR
QLQQADLAERIAATLASWRLPASSLEIELTESMLMADPLSASTLLRRLADFGVRLAIDDFGTGYSSLAYLKRFPVSRLKIDRSFVRDLQTDANDAAIIAA
VVAMATSLNIEAVAEGVETVEQLRFLQSRGCHVVQGHLFSPPRPAAALTTFHFPL-----
>tr|A0A080M193|A0A080M193_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-02 GN=gmr_17 PE=4 SV=1
------------------------------------------------------------------QAVLEREALLRESEAKYRGVVENTRDLII-RDRE
GAILDVNEAWLTLLGYARDEVLGRP---ITDFLDR-SLPVL----------AEPKFVLFDLRRKDGEMRTVLINGRITHDRQGL-ARSHCILTDITERQR
AEERQRRARAEFEAAFDKHYVCNDGRLITGIGNTSQE------------------IGEERRAEAATVFSAERILGVWRGEVWSLRKNGEIFPVWLTITAV
RNAGGEVTHYTGTFLDISERKQWEQDIHFLAHHDALTKLPNRTLLDDRIRQAIAKSKRNHDHMAVLFLDLDHFKLINDTLGHDIGDRLLEQLAQRLTEVL
RQTETVARLGGDEFVIVIPELAARRVAVVARKVLEVVAAPYLLEGRSLHVTPSIGISVYPEDGDDAATLLRNADTAMYHAKERGRNNFQFFTQAMNQSVQ
ERVTIENDLRLAIERGEFLLHYQPQVDCRSGKVIGMEALIRWQHPQRGLIAPDRFIAIAEETGLIVPIGEWVLGEACRQARRWQLGGHPGLRISVNLSAR
QFQQRDLSARISAMIHASGIDPASLELELTESMLMIDPEQATAVLHQLAAAGVKMAIDDFGTGYSSLAYLKRFPVTRLKIDRSFVRDLANDSNDAAIVDA
VVAMATSLKMEVIAEGVETIAQLDYLEAHGCHAIQGYYYSPPAAAESFVRFHYNR-----
>tr|G8QNH9|G8QNH9_AZOSU PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Azospira oryzae (strain ATCC BAA-33 / DSM 13638 / PS)
------------------------------------------------------------------DEL-------------------------------
-CLIQANRAFERLFGVSLETALGQT---VVGYYTPEEFADF----------GQYPAVLRRFRRADGTLFWANFYARQIDAQQPQ-RGIIIVIEDVDQARH
QEEVLRESNADFR-------NFRH-R------EEYSI------------------ITARRRAEEQKVFEGNRIMGTWQGEIWNRRKGGEVYPEWLSITTV
RDEAGEVSNYVAVFADVSERKRNEEHIRFLAEHDYLTGLPNRSLLHDRLQQAIALAERNSESLALMFIDLDRFKNINDSLGHQVGDQLLQEVGRRIQACV
RSADTVSRPGGDEFIILLPSIETQDAARVAEKLLESLNRPYQLGGHELVITASIGIAVFPEDGRDFQTLVKNADAAMYYSKEAGRDSFHFFTPDMNARVF
ERLSLENSLRRALERQEFLLYYQPQVDMPSGRVIGFEALIRWQHPQMGLVSPARFIPVAEDSGLIVPIGEWVLGEACRQNRAWQEQGMPAVPVAVNISAL
QFRQPQFEASVERALAESGLEPAWLELELTESMMLHQGQGATDLLDRLKARGVRLSIDDFGTGYSSLAYLKRLPLDKLKIDQAFVRDIASDAGGAAITAT
IIQMAHNLGLSVIAEGVETEAQLEFLQAHDCASAQGFYFARPMPAADIRAFWDDR-----
>tr|W6LQN7|W6LQN7_9GAMM Putative Diguanylate cyclase OS=Candidatus Contendobacter odensis Run_B_J11 GN=BN874_150003 PE=4 SV=1
------------------------------------------------------------------LAIREREQALVTSETRFRDLSTMASDWFW-EDEQ
FAVLEAHQPFR-------------------DF-------------------------EYCYTDPS-GEHWINVNGQPLFNETGHFVGYRGTGRDITERKR
MEEELASR----ESNFRRLCNCYQ-DAIIGRNNASGGVGGRHIANWL--------IGQVRDQTQD-----KKMLPTMPREQFERVA-QALFALAKQLST-
-----LAYQNVQQARFITERQRTEQRIEHLAYYDALTNLPNRMLLAQRAELALAMAARQRTGLAVLFLDLDRFKDVNDSLGHAEGDALLIQVAARLQEQT
RETDTVCRLGGDEFVLLLPDTNQEGALQVADKVLMAFRQPFPLAGHHLRVTVSVGIALYPHDGQNVNDLLKNADAALYQAKQDGRNTRSFYASEMNVATF
ERLVLESELRKAIAAGQLRAYYQLKIRLSDSQVVGAEALVRWLHPDHGLIPPGRFIPLAEASDLIVELGDWMLEEVCRQLAAWRSVRLLPLTIAVNLAAR
HFRDAGLVVRIQGLLTAHNLPPQTLELELTESSLLEAGPQTVETLLALERLGVGLAIDDFGTGYSSLSYLKRLPLTALKIDQSFVRDLVTDSDDRILAAT
IVALGHSLGLKVVAEGVETDEQRRILLDQGCDLAQGYFFGRPVPAEEFSAGLRRE-----
>tr|M1ZLN2|M1ZLN2_9CLOT Putative Diguanylate cyclase OS=Clostridium ultunense Esp GN=CULT_650001 PE=4 SV=1
---------------------------------------------------------------------------NK-HNCKYKEMFNNNHTPMLIIDAK
TNIDDANLAACSYYGYIRDKLLKMN---IADIKEEEVEEEIEKA------KKERKFFQFKHKLSNGEIRNVEVYTGPIKL--GNKELLFSIIHDSQERVE
LESKYKKNKNLFHNSPEAIAIVDRDYRVLEINNRFEDVFQYNLKDIREKDLTLLCDET----LYEASRESIRRGKFIKEEVKRRRKDGKLLDVLLLGFPL
VI-EGETIGAYCIYSDIREAKEREKKIELLTKCDVLTGLFNRDFFLSNLDYEILKNNRLDEKIVVIILCINEFKEIMEALGPLAADNILKEFALRLKEGV
GPEDIVARFGEDEFAILIPKIKDDKLNGLTGEIIECLNMPFYIDANEIKITTSGGISIYPDNSIETIALVRKAEIAMNKSKELNSNMPIKFQNSLDKEVQ
EYFWIKNSLTRALPNKELFLNYQPIYDTSVNRLVGVEALIRWEHKEMGIIPPAKFIPIAERTGLIHPIGDWVLLNACKQNKKWQDLGYEPIYISVNISAL
QLEKPGFIKVIERTLEESQLEPKYLQLEITETFFAHKYEYVEDTIGELNELGVKLAIDDFGTGYSSLGQLCQFSINSIKIDRSLISDVHKKSNKNKVVKA
VISLAKSLNIDLIAEGVETQEELRFLKENRCTVAQGFLFSKPVRAEKIEKSFQKTI----
>tr|A0A069RR92|A0A069RR92_CLOLI Putative diguanylate cyclase OS=[Clostridium] litorale DSM 5388 GN=CLIT_2c02980 PE=4 SV=1
---------------------------------------------------------------------------QSVGISNHLDLFENSHVAILIVNSR
TRIIDANNAACMLYGYERPHMKDAE---IEEIEDIEIGENTNKT------VGSK---TVVHRLSGGKCREVEVLKVPSAS--DE-DISYFIVNDISEIRH
IKKELELRKQLFENSPEAIAILDNEDRVVKVNRGFEELFKYSNIEIKGNYINLIVSQE----LKLEASGDVVCAKTVKRDSIRCTKHGEDIDVSILGYPI
IH-DGVQVGIYAIYTDITEKKKREKKIEYLAMKDSLTGTYNRSYFIENLMKEIMHR-DSHNGFAVMFIDVDDFKRINDNMGHNVGDMILRQISKRIVECI
GEKGYLARMGGDEFTVFLKNVDSVCVANIAREIVESLEEPIIYDEKEFHVGVSIGISLFPDDGYEAEMLIRKADMAMYNSKMNRSNNFEFYNSDLKKKAL
EEFILENELRHAIKREEFSLNYQPLVDVSSEKIVGVEALIRWNHKEHGFVSPAKFIPLAERKGMIGFIGEWVLEKACRQMKKWIDSGYPVRFIAVNISVK
QLESLEFLDNVKRIIRETGINPRHLEFEITESISMTNLKNRTEILRELDDMGIALSIDDFGTGYSSLGKLKKFAVRKLKIDRSFISDINIDPNNTAIVST
IIAIAKILNMKVVAEGVETLEQVEFLREKECDLIQGYYYSRPVTFDEFEKMIPQEI----
>tr|W8TPM1|W8TPM1_EUBAC Putative signaling protein OS=Eubacterium acidaminophilum DSM 3953 GN=EAL2_808p05640 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--MILSNN------------------------SSLEVGEEMDIQ------SGRLKDKEESVALDGLLYDDDK-LYTA-IF--EN-NAFATGINESAQVMS
LEKEIERERQLFENSPDAIVMLDSLDRVIKCNRCFEELFGYTTEELYGEFINYISPQE----LKSEASNAVTAGSIVKRETLRRTRSGKNINVLVQGHPI
MH-RGLQTGIYAIYTDITEIKKRERRIERLALRDSLTGLYNRAFFSDSLKKAAR-E-HGSNCFCVMFIDIDDFKKINDNLGHDSGDMVLKIAASRIRKCL
GEDDVIARMGGDEFVLLLRDVASSEAAVKAKKIIDSFKKPVRVCRRECHVSISMGITLYPQDGWDYSEIVRKADMAMYSSKNAGSSGFRFYVESLSQKSR
EEFEIETGLRHALYRGEMFINYQPIIDSSKNRIVGAEALLRWRHSERGLIPPGRFIPVAEKKDMIAGLGEWVLENTCRQIRSWNDMGIRLDFVAVNISVK
QLEDREFIEKVRRIVERTGIDPDQLEFEITESISMDNLKNRQGVLNELDKMGIRLALDDFGTGFSSLGNLKKLAVSKLKIDRSFISDINLNEHNTAIVST
IIAIARILGLSVVAEGVETREQLDFLRGESCDMIQGYFFSVPLSKSDFEKFVKLQS----
>tr|D6XYV9|D6XYV9_BACIE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS
----------------------------------------------------------------------------RDYRELYQELFEHHHLPVLIIEPE
TLIRDVNQKAVSFYQYSKDELMNMV---ISDIDPDTIKAKMYAA------KKNTNSFHFRHRLKDGEIRDVKVDSIPVDF--NGTHLLYSLITDITETLE
-------KDALFNQSPYAIAILNRDYRISEVNGHFEALFGYGREEVLGLSPEVIYPLDD--E--SSMIDQMERGVILTRDTLRKHKDGHLINVELIALPV
YI-EGEPYRYVGIVTDMSEVRAREERIDSLINQDKLTGLYNRYYVMRELEQDLIAAERYNQTATILFGDIDAFKSINENLGHAAGDELLRQMADLLQEVF
A-KALVARLSSDEFAIVFPRGTDFEVRERLGLFFNELKKPFTLHNEDFYITCSFGVARYPDNGRERDDLMLNADIAMHHAKKREGNTFDYYTDVLGNQVK
REFKVKTVIQRALDENLFHLHYQPTLSVQDGVIVGAEVLLRLDDPEEGRVSPGEFIPVAEKFGFIYSIGDWVLRNACKEALGTDAYRDGNLFLAVNVSVQ
QLENEAFPEQVDAILEETGFPAERLVFEVTEETSISDSDLVSGTLNALIEMGIQVAIDDFGTGYSSLGKIHQLNMHQLKIDQSFIRDIEK---TTDIVHA
IIAMGKSLRLNVVAEGVETEEQLAFLKEAGCDFAQGFYLHRPMPFADYRQLIE-------
>tr|Q31NI4|Q31NI4_SYNE7 Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Synechococcus elongatus (
---------------------------------------------------------------------------LAESESRYRLLFEANPEPMWVFAKQ
GQFLAVNQAASQFFGYSQQEFLAMT---VLDIQSEEEKTRFLQFFE--SLICDPAVGVWAYRHKQGHLVFADVLIHDFEF--DNQPCCLILAIDITEKQA
ARELAHQREKLLNDNRDPLLVISGDRRICYANPAAQKLLKLNLEQLESQSLDPLLSDKLTEW-------------------ALTLPDGSVAEVEIHRSE-
TD-WGNVTHFIGVQNDITEQKRYEEELSFSASHDVLTGLPNRAVLEDRLRQGCKMALRQKHSLAILFIDLDGFKLINDSIGHRSGDLLLVEVAQRMCEQV
RAGDTVARIGGDEFIILLVDLKLNDVISIADRLLASVARPYHIQGIYLHVTASMGITLSDGDIEQPTQLIQQADLAMYKAKQEGRNNYQWYTNDLNLRLR
ERVHLRNELQKAIETEAFELYFQPKIEGCSGQVIGLEALLRWQHPQMGFISPATFVPIAEDTGQIIPLSQWVLETACRQLRDLLQQGIAAPSVAVNISTV
QFRRINFVKSVQSALQKYQLKSEHLEIEITENVLFDNTEKAIEKLQRLKELGVNISIDDFGTGFSSLSYLKELPIDTVKIDRSFVQEINTDSRDAAITQG
IISMAHHLRLNVVAEGVETEQQFKFLQQSNCDQYQGYYFAKPMPFEALKQYLMDEA----
>tr|W6M2Z0|W6M2Z0_9GAMM Putative Diguanylate cyclase OS=Candidatus Competibacter denitrificans Run_A_D11 GN=BN873_210123 PE=4 SV=1
---------------------------------------------------------------------------LRQSEEKFTKIFQTTPNVVVISRMT
DVLLEVNPGFEAVTGYSRMEAIGHS---TLELAEPADRERMVADLH--LY--QVLYQLFNFRRKDGTVRIGQMSVRPITL--NDESCVLFVMQDVTESQQ
SERELRASELLFERSHDA----------------------------------------------------------------------------------
--------IMFGIAQDITEIKVARQRIEHLAYYDVLTGLPNRALLAQRAEWALALAMRHGQELAVLFLDVDHFKEVNDALGHSEGDALLAEVAVRLRALV
RAADMVCRIGGDEFVLLLPDTAQ-GALQVADKVLAAFREPYKVTGHVLNVSVSIGIALYPRDGADFNDLLKNADTALYRVKQQGRNACLSYDREMNAATL
ERLMVERDLRQAIGAGQLRAYYQPKVRLSDRTVIGAEALVRWQHPERGLVPPGQFIPVAETSDLIVELGDWMLEEVCRQIADWQARGWVVPTVSVNLAAR
HFRLPKLVERVGSLLQAYGLAPRLLELEITESTLLEVSSQTTETLRALEQLGVGLALDDFGTGYSSLSYLKRLPLTALKIDQSFVRDLVADSDDRTLAAT
IVTLGHYMDLVVVAEGVETEEQRSILFEQGCDLAQGYLFGRPVPASEFIGWLT-------
>tr|U5N8H9|U5N8H9_9BURK Signal transduction protein OS=Candidatus Symbiobacter mobilis CR GN=Cenrod_1540 PE=4 SV=1
--------------------------------------------------------------IDD---RKKAEAALERYRQNLEANVRQLPGMLLRPDGS
ACFPYASEGIAGICGLTAEDVRATP---AFARVHPDDVPTVWRSAQVSATTGQTWRLRFRVVNDDGSMRWIDGSGTPRTEPDGSCLWH-GFMTDATADIE
AQNSLRLAASVFANAQEGITITDADCRILDINPAFSRITGYRREEVLGKTPKLLSSGHHDEQFYRRMWQSLHDQGTWRGEVWNRSKRGEVYPELLSIAVV
KDNAGQVSHYIGSFSDITGIKEREAQLNRLAHYDPLTDLPNRRLFTDRLRQGIALTQRQGKIMAVCVIDIDRLQAINDFCGLPAGDQVLVELSRRIRACL
RERDTAARLGGDAFALLLLDLKWEECDTILRRILLDLAAAVMLDKQSASTTASMGVAMFPQDGQDPETLLRRADTALREAKKAGGAQYRLYNPEHDRLVR
ENRRLIEDLTQAISHDQFILHYQPRVEIATGKVTSVEAMIRWRHPERGLLMPAEFLYAMSDTELETHLGIWVLHNALGQIAQWKRHELR-LPISINLSAR
DICHAGFPDGLAKALSQHTVVGADLEIEVPESQALAHAEDMATVIAACHDLGVRIALDGFGMGNSPLSYFRTLPVDVLKIDQDYVRDIHQDPDDLATVDG
IVKIARAFRRDVVAVGVEHPEQGQILLQLGCRYAQGYAYAMPMPADSLAQWMG-------
>tr|A0A011QLQ9|A0A011QLQ9_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-93 GN=gmr_4 PE=4 SV=1
--------------------------------------------------------------ISE---RKELEASLREQREFFRLISESIGEHIAVLDLE
GRRLYNSPSYRQFFGVSRD-LQGSD---SFADVHADDRERVIDAFRQTAETGVGQELQYRLVRHDGSVRHMASTGKVINDKSGKVMRVVVVSHDVTDKKQ
AEQWERIAATAF-ESQQGMFITDANGVILRVNKAFTEITGYSSADCVGRTPKLLSSGRHDATFYSAMRDTLQRTGTWQGEIWNRRKNGETYPEWLTISAV
WDSDEKVTNYVSTLTDITMRKQAQEEIRHLAFYDALTGLPNRRLLHDRLRLALVASTRRDRQGALLFIDLDNFKTLNDTLGHDMGDRLLKQVGKRLSACV
RERDTVARLGGDEFVVMLEDLARPQERGIGEKILAALNRPYDLDGHEYHNTPSVGITLFGDRQEGIDELMKRADLAMYEAKAMGRNTLRFFDPQMQAVVT
ARASLEKDLREALQRNQLRLFYQPQVDAA-GAVIGAEALVRWQHPQRGFVSPAEFIPLAEETGLILPLGLWVLESACAQLAVWAEQVRR-FTVSVNVSAR
QFRQPNFVDQVLAVLASSGADPQRLKLELTESMLLDNVQGMIDRMGTLKDHGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDLLTDPNDEVIART
IIALASTLGLSVIAEGVETAAQRDALAAQGCHAYQGYLFSRPLPVADFDAFLA-------
>tr|E1QJ78|E1QJ78_DESB2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-180
--------------------------------------------------------------IDQ---QKRDQQTLQTQRHLLELFVEHAPASIVMLDSD
LRFVMGSKAWVDSFGLRGQDLTGRQ---LY-EILPNLPERWKAVYKRCLDGAVEHMEEDILDRPDGQVDWCRWECRPWYSAEEKIAGLMLYLELITDKKK
AQDQLDLAFKFFDNAIEGVMVTNAEGVIETVNRGFTIITGYNPDEAIGKTPRLLRSDHHGPEFYKAMWQSIRQHGEWSGEIWNRRKNGEAFLEWQTIMAQ
RDAEGNVLRYVSIFHDITDVRLSEEKIEYQANYDALTDLPNRTLFIDRLNLAIDQARAAKQMVAVISLDLDNFKNVNDTLGLPLGDQLIKLVGHRLAAMD
GPSVNVGRQGGDEYLIMAEGLTHRQGVKVVHDISALFAEPFHLAGKELFLTSSMGLSFYPNDGADAATLLKNADTALHQAKLRGKNTYHLFEPRLNAMVS
DRLNLENRLRKALERQEFLIYYQPKVDLRDGRMKGMEALIRWQSPDEGLVPPDMFIPLAEETGLIVPIGQWVLDAACQQAKLWRDKY-E-LRVAVNLSPR
QFQEVDMMSLVSYALSNSGLTPDGLELEITESLVLPNLNEASSILKRLADWGLTITMDDFGTGYSSLSHLKNLPLDYLKIDKSFIMDIKSEGEDATLPGT
IISMAHSMGIGVIAEGVETQAQLAILRRLNCDYIQGYFYSRPLPERQFEELLA-------
>tr|C5BTR2|C5BTR2_TERTT PAS sensor diguanylate cyclase/phophodiesterase OS=Teredinibacter turnerae (strain ATCC 39867 / T7901) GN=TERTU_3984 PE=4 SV=1
---------------------------------------------------------------------------------DLENIQNALEIPFLLISKE
YRILRFTENCSHIFDTQHIQI-GDL---FFAVDWRGNAGQALILAAECEAKSQIAEL-------EIDDRSYQCQVSPYINASHVFDGYIVIFYDMTNLTR
SKEALAFEKAQLELVAEGVIRLNTRGTVEYINPAALKILCKSHDEIAFQRLSEISLYDEVGQFVQRCLQSNESFVVENNPLLIHTGSETANYIELSIVPL
Q-LSDDVRGCIITLRDTSERHRQLERLKWQSTHDSLTGLVNREEMEKRLERAIATSRREGIESSLLYMDLDQFKVINDTCGHLAGDQLLKQLAQLIRDML
RTRDTFARLGGDEFAILLDHCPILEAEAIAQKIKQKVCDYRAWEDKAFRVGVSIGIVGIHPSVSQLSQVLSDADAACYAAKEAGRNCIQIHTQDNKVLEA
QRLQMRSDINQAIESDHFRLYFQQIHAVGSGAIQSWEILIRMFNATGEFLLPSHFLPAAERFGLINRIDTWVMESALRNVAQYFGQGKERFLLSFNVSGA
TISDPAYLDLVSELFTRYQYPANKISFEITETSVVRNLVKASEFMRRARELGCKLALDDFGTGLSSLSYLGELPVDRVKIDMSFVKNIVDNPVNRAIVNS
VKEVAHLLKLEVVAEGVETPAQLACLRELGVDAYQGFLAGKPLPFEEFVCRSLDTI----
>tr|G4QJL1|G4QJL1_GLANF PAS sensor protein OS=Glaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064) GN=GNIT_0517 PE=4 SV=1
---------------------------------------------------------------------------------DMTNLLESADIAALFLDVK
FCIKRFTPAMRALFQLIKSDV-GRP---ISDISHQFVTLDLVKEAELTLKNRLMNEIEV----KTTDDKCYIVRISPFRTNDGEIEGVVVTFFDITRLNQ
IKSSLSSSRIE----GEAIYGVDVSGKCTFVNAKLVQDLGFTEQELIGRDSTIFHHTRSDGCFVYQCLKDQKPHRG--ANDLVWRKDGTSFPISYSVGPI
I-EHGELRGAVVIFRDMTKEYASINKLDYQARHDALTGLINRREFDERLERVLQNSPEDQDQHVLCYLDLDQFKVINDACGHLAGDELLRQLSNVLQSHV
RKRDTLARLGGDEFGLLMEHCDLHEGKRVANGMRDAVANYRFWQGNTHMVGVSIGLVEIIGDGQDKTDLLKAADAACYAAKENGRNRVHVYSEQDTNMAA
RHGQMKARINLALENNRFLLVLQPIVPINGVDKLSYEVLIRMRDG-DNIIQPDDFLGAAERYNLSSKVDLWVIRNTFNWMTDN--KHQLEVLININISGQ
SLGDQEFLKHVVNALKAKPIPTGKICFEITETAAITNFTNANSFMHALKNLGCEFALDDFGTGLSSFEYLKALPVEYIKIAGLFVKDIATDSVNLAMVKA
ISDLGHEMNKKVIAESVENKEILDCLVELGVDFAQGYFFGKAVPLSEIKLNESDIT----
>tr|A0A0D0NUR5|A0A0D0NUR5_9GAMM Contig_110, whole genome shotgun sequence OS=Aeromonas sp. L_1B5_3 GN=RW26_21560 PE=4 SV=1
---------------------------------------------------------------------------------EYSHLYDALEFPILVFDKE
LRLIRFNAGAAQYFSLRLTAH-YQS---VEKINFPDEFNELATLLGKTLSHGDRQSALI----Q-HLNRYFHLIITPGLNQKSEVISLVVTMIDVSDLIN
AKNKLSASELTMEHTSIIFSMRDLHGRYLYVNKRFTECFDVDEADCIDKTDSIF----KNQHQTLRISYSIKTDGSWKGEILSKRKGGEVYPELLTINRV
EDFQGNPEHLVAVFSDISQIKNSQKDIAYLAEHDSLTNLPNRATFANKLRKQLAESLDNNRTNALLFIDLDNFKNINDTLGHDVGDRVLQIAASRLRHII
NSNDFIARLGGDEFTIILSDTTTEDAAAVAKKVIDEMSLVYEVANRQLFISASIGVAISPMDGHDEHSLLKAADAAMYKAKENGRNRFAFFEPELQVKLL
RQATLERAMRVAIENNLFYLVYQPKFLINDKLIVGAEALIRWDDPEVGSVSPADFIPLSEKNGLIYEITRIVIHTIIQQLVQWRKEGLKLLPIAFNCSTR
SLHEPDLADFVLSLMRENSLPFELLQIEITETVLLDNSQVALSNLERLNYHGIKINIDDFGTGYSSLSYLKRLNISTLKIDQSFVSGLGNDLEDEVITEA
VLSMAKSFSLETVAEGVETETQLCWLRQHGCHVAQGYYLAKPLTTNAFKEYLTLE-----
>tr|A0A0B1PMR0|A0A0B1PMR0_9GAMM Uncharacterized protein OS=Halomonas hydrothermalis GN=PZ78_15420 PE=4 SV=1
---------------------------------------------------------------------------------EYAYLYDALDFPLLVFDGE
LCLKRYNAPASRYFSLRPTAL-QRH---VAGLRLPAVLNDLEDVLLEVGEQASPVESIL----E-LEGRLLQRLVTPGINQEGSVELLVVTLMDVTDLSH
VQAKLRQSQLHMENSTVMIALKDLNGRYTFANPRFLESFGLTQEQLIGRNVELF----EGHHQLLRVWEIVQQTGYWQGEVYNKRHDGVVFSQWLTLNRI
VAETPEETLYVAVFSDISHIKDTQRQAEYLATHDALTGLPNRTLFQDRLQIAIAAAKRSDQLSALMFLDLDNFKSINDTLGHDVGDELLIQVASRLKELV
RDMDTVARLGGDEFTIILMETSIEGAEQVAKRIVEAIAKPFDVRRHTLFVTSSIGLAFCPDDGDDVAGLTKAADTAMYRAKENGRDRFELFKPELQARLM
RDVAIGQALREGMEHGRLHLVYQPKYTCKDGHLAGAEALLRWQDPVLGAVSPVDFIPVAEATGLILDLDRHVALMLIRQIAQWREQGLQPLPVAMNVSAR
SFQEERFITHLFGCLKQYRVPHALIQVEITESTLVDRSSSALGNIEKLREAGIKLAVDDFGTGYSSLAYLKRLPLAELKIDKSFVDGLGGDESDQAIALA
ILGMASALGIRTVGEGVETAAQLAWLVENGCDFVQGYYLSRPLALDAYAELIRVNG----
>tr|A0A061JVA9|A0A061JVA9_PSEST Uncharacterized protein OS=Pseudomonas stutzeri KOS6 GN=B597_004820 PE=4 SV=1
---------------------------------------------------------------------------------EYTHVYDALDFAVLVFDRE
QHLVRFNAAAARLFGFKHAAI-HQH---VSRIRLPSHFRVIEDCLDQAKNRREPQELLI----E-HHGRQFHLQITPGVSLEQHVELLVCSLVDVTDIRK
TESDLRSSRLEMANTIVLLSMKDLSGNYTFANPAFLESFGLVDGKVEGRNDELF------QHQVLRMWSGLENRSFWQGELTNRRKDGALFSEWLTINRI
HES--ANDYYVAVFSDITRIKESQAKAEYLATHDALTGLPNRSLFQDRLDLAIAQARRSNGIAALMFMDLDNFKGINDTLGHDIGDQLLVEVSRRLSSLM
REVDTVARLGGDEFTVVLTDIDFAGTERVAERIIQALRQPIEVGSRNLYVTGSIGLAFYPDDGETSTTLIKAADTAMYRAKHNGRNGFELFKPELHAQLQ
RQSNLEAALREALRECHLRLVFQPKFTTEAPRMIGAEALLRWTHPEMGVVSPADFIPAAETGGLIKEVDRKVIQLAVQALAYWQGNELDPVPVAVNISAR
SIQDDHFPDMLAKRLHQYRVPATLVQVEITEGTLLERTSTALGNIQRLKEMGVRLSIDDFGTGYSSLSYLKRLPLAELKIDKTFVDGLGGDKSDEAIAKA
ILAMAAALNLLTVAEGVETEGQLQWLSDNGCDYIQGYLCSRPLEYLDFTEKLKNGN----
>tr|Q2W1Z2|Q2W1Z2_MAGSA Hypothetical 1041 kDa protein in hypE 3'region OS=Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) GN=amb3329 PE=4 SV=1
---------------------------------------------------------------------------------DFEGVYNTIDFPIMVFDPE
LFLKRANGAAVRTYDLPLSAS-GMH---IGRLKLPAFLDNIDKSLTAALTEQRKESFQI----T-FGKRTFQVFVTPSMSMTGTPQSVVLVVVDHTDLVE
AQEQIRESQLLMNHSTSAVSLKDAAGRYEFINMRFEELFGLSAEEVIGKTDQLF-----TSRFPIFMWRSLIEQGCWQGEIFNRRKNGEIYPEWLTVNSV
RDENGSVVNYVAIFSDISAIKSSQRRIEFLATHDELTGIPNRSLLMDRLKHAVAQAKRQKTKLAVLFIDLDNFKVINDSLGHDVGDQLLKQATERLKHCV
RDSDTLARLGGDEFVAVLTDVSLEKVNSVAARIVDFLGASFSINDKSLFVSASIGISVFPDDGQDSLTLLKHADTAMYRAKERGRNQYQFFADEMKVIAL
QRLTLETGLRLALETKSFRMCYQPQVDIHTG-VVGAEALLRWRDPTLGEVSPAHFIPIAESCGLIGAIGETVFTMVLEQIAYWREKGLTVPRIAINVSAH
QLRDAGFAAKVGSWLDSSGISSELIGIELTESALMERIDMVKEMLTSFDGMGMKVSIDDFGTGYSSLSYLKKLPIHELKIDRSFVDGIALERDDRSIAKA
IIDMSRALGMRVVAEGVESEEQLGVLKEEGCDMVQGYLFHRPLSPEAFAKVIETGG----
>tr|A0A0D2VRC2|A0A0D2VRC2_9PROT Skermanella aerolata KACC 11604 strain 5416T-32 contig50, whole genome shotgun sequence OS=Skermanella aerolata KACC 11604 GN=N
---------------------------------------------------------------------------------DFESVYNTIDFPIMVFDPE
LFLKRANGAAVRTYDLPSATS-GLH---IGRLKLPDFLDTIDRNLSTALSTQRKDSFQI----L-SGKRTYQIFVTPALNPTGSPKSVVLVVVDHTDMVE
AQERIRESQLLMNHSTSAVSLKDAAGYYEFVNLKFEEVFGVKGADVIGMTDQLF-----SARFPIFMWRSLSEQGCWQGEIYNRRKNGEIYPEWLTVDSV
RDDNNVVVNYVAIFSDITAIKSSQRRIEFLATHDELTGIPNRSLLMDRLKHDVAQAKRRNAKLAVLFIDLDNFKVINDSLGHDIGDQLLKQATGRLRSCV
RDCDTLARLGGDEFVLVLMDVELKKINSIAGRIVDFIGGSFDIAGKTLFVSASIGISVFPDDGEDSVSLLKHADTAMYRAKERGRNQYQFFAEEMKVVAL
QRLTLETGLRLAIESRTLRLCYQPQIDIRTG-VVGAEALLRWTDPNLGDVSPNQFIPIAESCGLIGQIGEVVFRMALGQIAEWRRSGLNVPRIAINVSAH
QLRDAGFVDKVGSWLKESGQSADAIGIELTESALMERIEVVKEMLVRFDHMGVKISIDDFGTGYSSLSYLKKLPIHELKIDRSFVDGIATDRDDRSIAIA
IIDMSRALGMRVVAEGVETEDQLGVLTEEGCDMIQGFLFYRPLPPEAFAEVLRSGG----
>tr|G4T393|G4T393_META2 Uncharacterized protein OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) GN=MEALZ_0891 PE=4
---------------------------------------------------------------------------------EFESLYNTMDFPILVFDCH
LILKRSNLSAMRQLDISMSGN-NRH---VSRIDFPPYLVDIEKRLLNAADKQRKENYTV----Y-LNDRSYQVYITPTINTTGVTQSIVLFIIDNTELVA
ANRLIKETQLLMNHSPYLVSLKDTAGRYEFVNYRFCELFGVSGESILGKTDQLF-----SRHFSIFMWNSIKGNGGWQGEINNRRADGTVYPEWLTISAV
HDVSGELVNYVGIFSDISAMKASQNRIEHLATHDELTGLPNRTLLMDRLRHNLFQAKRKKESLAVLFIDLDNFKNINDALGHEAGDVLLKQATDRLLACM
RDADTLARLGGDEFVAILYNIDGADINRIAIRVVDSLSASFRIYDRDCFVSCSMGISIYPQDGEDSTTLLKNADTAMYRAKDQGRNQFQYFADEMKLKAL
QRLTIETGLRLAMDHQRLFLHYQPKIDLPSG-IVGAEALLRWHDPNLGNVSPAQFIPVAESCGLINKLGEQVMTMVAADIHFWKQKGVEVPPIAINLSVH
QLRDKRFGDILISRLSEFDVPAQAITLEITESMLMERIEETERLLADLSAQGFKISVDDFGTGYSSLLYLKKLPIDELKVDRSFVDGIDEQSEDRSITDA
IINMAHALHLKVVAEGVETEAQLRVLRSLDCDVVQGYYYYRPLSANQFYAVLAQ------
>tr|U5NBJ4|U5NBJ4_9BURK Signal transduction protein OS=Candidatus Symbiobacter mobilis CR GN=Cenrod_2640 PE=4 SV=1
---------------------------------------------------------------------------------DFESLFNTLEFPVLLLDNQ
LQLKRANGAAMRHYALSMSST-GQH---FAQLDLPYHLRQLETQIGNVVFHAARESITV----D-GEDRVYQVFITPVVTGPPIAQGVVLAVVDETELVT
AQQKTTESELRMHHSMSLVSVKDATGCYEFINHRFETIFGLHAEDVLGKTDQIF-----TARFPIFMWHSLTEQGSWQGEIVNRRRSGDVYPEWLTINAV
KNDQEQIVHFVAIFSDISALKSSQQRIEFLATHDELTGLPNRSLLNDRLRQALFLAQRQTHKLAVLFIDLDNFKTINDGLGHDVGDGLLKQVAQRLRQCI
READTLARLGGDEFVALLPAVHLEEVNQIAARIIDNMATAFTVDANVLHVSASIGISVYPEDGDDTVSLLRNADTAMYRAKDRGRNQYQFFVEEMKVLAL
QRMAMETGLRSALEHDRLYMVYQPKVDLRTG-AIAAEALLRWKDPILGDVPPSQFIPIAENCGLIDAVGNRVLDMVLRQIARWREQGLQVPRISINVSAH
QLRDPDFVQHLIARLEYLHVPASNIGIELTESVLMQRIDVVRERLIQLAALGTTLSVDDFGTGYSSLAYLRKLPLHELKVDRSFVDGIAVERDDRSIAKT
IIDMAHALGLQVVAEGVETQEQLQVLEQDGCDVVQGYLYHRPMGAAEFEKLLAAPS----
>tr|D9SIA4|D9SIA4_GALCS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Gallionella capsiferriformans (strain ES-2) GN=Galf_0116 PE=4 S
---------------------------------------------------------------------------------ELENLQNSTGFSLILLDQE
LRLQRYNKEAASLFGFSVHTL-GKS---IPGLAVPVI--DVLETAKL-AMSDGIKRQKQ----MSFGGKHYNVLCFPYTSQDQTLGGVIVTFIDQTELME
AQQEILSSKLTMQNSPMLISIKDPAGRYQFVNNAFESIFALTPGSAIGNTDQIF-----DQCYPINMWQEINQHGWWQGELWNRRKDGTHYLEWLTIHTL
RDEHGHLTNYIAIFSDITLIKAAQRRLEYMVAHDELTSLPNRNELRGRMAQTFARAQRHGGTFALMFIDLDNFKNVNDNLGHDYGDVLLQQVAERLGLCV
RTEDTVARIGGDEFNVLLDDVSETQIANTAQRILDHVSKPYLIKEQQVFVSASIGIAVYPKDAEDIETLTKNADSAMYQAKDKGKDSYQFFTSDLKEKIN
HRIEIGNALHKAIDANELKLVYQPEFNLQTG-LIGAEALLRWHSSLFGIVGPDEFIPIAEESDLILELGEWVIEQAARQLNLWRKADTPLPTLFVNVAPR
QLARQPLLAIITRQLQKHRLPSGSLGIEITERTLVNSSEDISVKLHKIELEEIPIAIDDFGTGYSSLSYLKSFPISFLKIPNQFIDGITTDESDKGIATA
IHGVSVALKLQTIAEGIETEDQLIMLREMGCQSGQGYLLGRPVDPNQFVELFISNR----
>tr|C7RN47|C7RN47_ACCPU Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Accumulibacter phosphatis (strain UW-1) GN=CAP2UW1_2118 PE=4 SV
---------------------------------------------------------------------------------ELESIQNSVDYPLLVLDRN
ASLQRFNSAAARLFKLGAAQT-GRH---LRDLPLPPDMPDLLADVQHVIDTQNARDRQI----VNANRRHYALHIAPLLRDTQRIAGVILLFADNTSLYE
VERSARETQLQMNNSVSLMAVKDAPGRYQFANPKFEQTFGFATGEVIGKTDQLF-----AGRFPLFMWDKVTRLGVWQGEIWNRRKNGEPYLEWLSINTV
KDKNGKVVNYVGMFSDITKVRESQQRIEYLATHDELTGLPNRALFNDRLNLALAHAERSRESVGVVFIDLDNFKVVNDTLGHETGDKLLKQAAMRLLECV
RAEDTVARLGGDEFVVLLVNADRQQATLTAERLLTGLSTSYHFGEHECFISASIGLSMFPEDASDANSLMRNADSAMYRAKDHGKNGFRFFSADLASQAS
KRLALETGLRRAIENGELFVHYQPQVRLECD-VVGAEALVRWRYNG-EVIDPVVFIPIAEQSHLIFAIDDWVLGEACRQIIEWDRAGLPPLRISVNISAR
HFRKDGMAADLMDIVSAHGVSPQRLCIEITEGVLMDVDRAQ-RMLAELVESGLRISIDDFGTGFSSLSYLKRFPIHELKIARSFVDGISTDADDRAIASV
IISLARQLGMSVVGEGIERTGQHAELEAFGCHRGQGFLYAQPLAPDAFADWVLART----
>tr|A0A080M5F0|A0A080M5F0_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-02 GN=gmr_12 PE=4 SV=1
---------------------------------------------------------------------------------ELECIQNSVDYPLMVLDQN
SALQRFNSAAARLFRLGEPQI-GRH---LRDLALP-DMPDLVTDSQKVIDTQNALDRQI----VNANRRHYALHIAPLLRTSQRSAGAILLFADNTNLYE
IERSARETQLLMNNSVSLMAVKDASGRYQFVNPKFEQTFGFAAGWVIGKTDQLF-----SGRFPLFMWDRVNRLGVWQGEIWNRRKNGETFLEWLSINTV
KDKSGKIVNYVGMFSDITKVRESQQRVEYLATHDELTGLPNRALFNDRLHLALARAERSRESIGVVFIDLDNFKVVNDTLGHATGDKLLKQAAMRLLDCV
RAEDTVARLGGDEFVVLLGTADRHKATLTAERLLSALSTSYQFDEHECFISASIGLSMFPEDAADASALMRNADSAMYRAKDHGKNAFRFFTADLAHQAT
RRLALETGLRRAIENGELFIHYQPQVNLENQ-VVGAEALLRWQYNG-EVVDPVVFIPVAEQSSLIVSIDEWVLGEVCRQIDQWNKAGLPAVRISVNISAR
HFRKEGMAADLMQIVNAHRVSPQQLCIEITEGVLMDFERAQ-RMLAELVAFGLVISIDDFGTGFSSLSYLKRFPIHELKIARSFVDGISSNADDRAIGSA
IIALARHLGMSVVAEGVELTDQHVELDASGCHNGQGYLYSRPLPPDDFAQWLRERN----
>tr|A0A011MCE3|A0A011MCE3_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. SK-12 GN=gmr_5 PE=4 SV=1
---------------------------------------------------------------------------------ELECIQNSVDYPLLVLDRN
LGLQRFNSAAARLFKLSAAQS-GRH---LRDLQLPPGMPDLVASSRQVIDTQNALDCQI----VNANRRHYALHIVPLLRDVQRIAGVILLFADNTNLYE
VERSARETQLLMNNSVSLMAVKDASGRYQFANPRFEATFGFASGHVIGKTDQLF-----NGRFPLLMWERINRLGVWQGEIWNRRRNGEPFLEWLSINTV
KDETGKVVNYVGMFSDITKVRESQQRIEYLATHDELTGLPNRALFNDRLHLALARAERSGEHMGVVFIDLDNFKVVNDTLGHVTGDRLLKQAAMRLLDCV
RSEDTVARLGGDEFVVLLESTDRREATRTAERLLGALSASYHFEEHECFVSASIGLSMFPEDAADAGALMRNADSAMYRAKDHGKNAFRFFTADLARHAA
RRLTLEAGLRRTIESGELTVCYQPQVILGSQ-LIGAEALVRWHYNG-ETIEPVEFIPVAEQSNLIVELDEWVLGEVCRQVASWDAAGLPPVRISVNISAR
HFRKEGMAGELMRIVSAHGVAPQRLCIEITEGVLMDVDRAQ-RMLAELVACGLTISIDDFGTGFSSLSYLKRFPIHELKIARGFVDGISSSADDRAIGSA
IIALARNLGMSVVAEGVEQPDQHAQLDASGCDHGQGFLYSRPLTADEFVHWLQERG----
>tr|A0A0C5ITL9|A0A0C5ITL9_9ALTE Alteromonas australica strain DE170, complete genome OS=Alteromonas australica GN=EP12_03275 PE=4 SV=1
---------------------------------------------------------------------------------ELMSVYNTLDFPILVFDMD
HCLNRTNDAANRRFHLNNGSF-RKP---MDTLNFPDYFEDIEMRLNKTLQTGVAENVII----KPSSQETYNVFITPIFNSRERITGAIIVIIDNSELVL
AHERIEKSQLLMNNSLAVIALKDNAGRYEFVNARFEEVFGLHADEVVGKTDQIF-----LGRFPIFIRASLSERGFWQGEAEIKVKSGSSVTMWLTVNAV
KGGDGDIVNYVAAFSDVNEIKDMQRRIEYLATHDELTGLPNRAVLLERLELMVGNAKRAEQLCAVLFIDLDKFKPVNDNLGHKVGDLLLKQVTKRINKCI
RDTDMLARLGGDEFVAIVSAARVDEIDEIAKRIITQVETEFQVANHQIAISASVGVAVYPNDGITSDVLLHHADEAMYHAKSLGRGQYQYFTARMMEKAQ
ARVQIEARLKSALQERQFSLVYQPQYDIASN-IVGMEALLRIANDEQDITRAAEFIDVAEKANLIDAIGFHALELVAFDLKMAMQKGISLPRVSVNLSGK
QLLTSDFTKRFEQLLSRTSLPAEAFKFEISERDIQKGEKRIFHRLQSLKSMGAVICIDDFGIHQSAVAQLQQCGASEMKLSRQIIEQPDD--ASEQLLRA
YIDVANVLGMTVVADQVETEEQMDYLVSVGCELAQGFVFSAPVTFDNMLEKLDR------
>tr|F5Z500|F5Z500_ALTSS Uncharacterized protein OS=Alteromonas sp. (strain SN2) GN=ambt_15285 PE=4 SV=1
---------------------------------------------------------------------------------ELMSVYNTLDFPILVFDTD
TCLSRTNDAANRRFHLNNGSF-KKP---MYSLNFPGYFEDIEKRLSKTLRNGVNTSMVI----KPSSQETYNVFITPILNSRERITGAVLVIIDNSELVI
AHERIEKSQLLMNNSLALIALKDNAGRYEFVNARFEEVFGVTAQDVIGKTDQIF-----AGRFPIFMDASLTERGFWQGEVINKVKDGSHVKMWLSYNAV
KDANGDIVNYVAAYSNIDEIKNMQRRIEYLATHDELTGLPNRTVLLERLELMISGAKRSKQLCGVLFVDLDNFKPVNDNLGHKVGDLLLKQVTKRLQQCI
RDTDMLARIGGDEFVALISASHIDEIDDIAKRIISQVQNEFDVSTHSISVSASIGIAVYPADGISSEILLQHADEAMYLAKSSGRNQYQYFTAKMKEQAL
ARLEVEKQLKVALDGKQFSMVYQPQFEPTSN-IVGAEALLRYKNSDGEVLNAESFINIAERGKLIETIGFHAVELVAREIAQYIQLGSKLPAIAINLSGS
QLLTSDFIKNFVAVLDRYELTPGLFKFEVSEKDIESGEERIYHRLRTLASMGSVISIDDYGLYKSAISQLQQSGASEIKLSSRLLTDVSDNNDSNKLIHA
LINAGKALGLKIIADKVETQQQLDYLRDIGCDVVQGLVFSPMLTCAELNKQIS-------
>tr|G4ST09|G4ST09_META2 Putative methyltransferase CheR OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) GN=MEALZ_1
---------------------------------------------------------------------------------DLRNILESIEMAVIVIDSR
MRITRYNGVGQRFLQLSSMANGKLT---IESLEILFGCENLVGPVQQVIQTQRSVLIKK----E-KQGLHYDLTLYPYRRLG------------------
------------------------------------------------------------------LWHTLEESGSWQGEIWNKRKNGEIYPEWLSISAL
KEAEGGVSKYVGIFSDIGDSLRAQQLIHQQANFDALTQLPNRNLFYDRLQQAITKAQRERKLFGLMFIDLDGFKDINDALGHSLGDRVLQEVAARMAHVF
RESDTFARFGGDEFTVLVPNLESTDMIAPTEKILEAIQMPIQADDHELNITASVGITIYPNDGREAETLLKNADNAMYSAKAEGRNAYRFFTQEMHEKAQ
RQHRIVNDIKNAVKFERFIVYYQPVVDLQSQ-LCGAEALIRWQHPVRGFISPDEFIPVAESLNLIGQIGEFVLAKACHFIAGLNSELGADLSIAVNFSSL
QFVNGSCVDKWLDMINESGVGASNFVVEITESLMMSHKEHYIRQLQKLRSQGIKIALDDFGTGFSSLSYLKKLPVDIIKIDRTFIRDILVDPSDASLVES
ILDIANNFRLEVIAEGVEDEGQAEFLKARPCAYAQGYYYSKPLPEDEFKQFAMGKR----
>tr|H8GJU0|H8GJU0_METAL PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Methylomicrobium album BG8 GN=Metal_3993 PE=4 SV=1
---------------------------------------------------------------------------------DLRNVLDSMDKAVIVVDSR
MHINRINEASKKYFNGGFIDGTQPN---LNTLKNALGCEDLIGRIQQVIDTGATYHSKL----P-IQKKYFELVIYPYFSRI------------------
------------------------------------------------------------------LWQSIKDTGKWQGEIFNKRKDGSVYPEWLSISTL
KDESGKVLHYIGIFTDISAAYKDRETIIQQANYDALTHLPNRNLFFDRLKQAIANAGRARELVGVMFIDLDGFKDINDALGHSLGDILLQRISQRMVGIL
RESDSLARFGGDEFTVLVTGLQKADIIPTVEKILEAIQAPIVVDDHELNVTASIGITVFPNDGKDGETLLKYADSAMYTAKAEGRNAYRFFTPSMHEKAK
IQHSLSNDIKIAIKNNQFTVHYQPVYDLFRK-IVGAEALLRWQHPLRGNVSPEEFIPLAESLNLISKIGELVLSEACRFMAGLNRILQEPLYIAINFSPL
QFVAGNCAENWIDIIESSGMNSSHVIVEITESLMMSHQANYMLQLQLLKQQGIRIAMDDFGTGFSSLSYLKKLPLDILKIDQSFIRDVLWDPNDAALIET
IIAIAKNYSLELVCEGVEEKGQVDFLVQRGCRYAQGFYIQRPVPGEQFIELAKNGV----
>tr|A0A059KJS7|A0A059KJS7_9BURK Uncharacterized protein OS=Sphaerotilus natans subsp. natans DSM 6575 GN=X805_28150 PE=4 SV=1
---------------------------------------------------------------------------------ELQSIQNSIAMPMLVIDET
FCINRYNLAAERLFRLSRGAT-GLP---LSTMYRPSGIPDLVAAIVQAQASASPLSLDL----PPGDGREYVLHLSHNV--GGERRGVVLTVVDNTDLAR
AERQTRQVELLLSHGQALMAIKDTSGRYQFANARYAEFFGLEADSLVGRTDQLM-----NGRFGLHLLAKVRQQGRWQGEVLGRSADGSTATCWMSASPL
ADETGGITHVVVALTDISDLTRTREEMRHQATHDALTTLPNRSLLMDRASHAIDNARRQRTEIALCFIDLDHFKTINDSLGHDAGDEVLKLAAQRISGCV
RACDTLARLGGDEFVLLLENTSRHECLLTVERIQLLLAEPIPFRGTLLSTSASIGVALYPGDASDAATLLSHADAAMYRAKNAGRGRCEFYASEVGSSAR
QRLHIESGLRQALGRDELVLHYQPQVDLRTG-VHGVEALLRWAPSG-TLIAPSVFLPIAEESSLIERIGDWVLDQACRQLAAWRAQGHVELCMSVNLAAR
QMRDAGLPDRLQQLLIAHGVPGECLVLEITESALLRRDEALDRVLRRLEMLGVQLSLDDFGTGYSSLALLRHLPIRELKIDRSFVQGMADQRDDREIVEA
VIGLGRALGLRLVAEGVETEVLQQCLRERGQDLVQGFLRGRPMPAGECGRWLASAA----
>tr|N6WWB0|N6WWB0_9ALTE Uncharacterized protein OS=Marinobacter nanhaiticus D15-8W GN=J057_11006 PE=4 SV=1
---------------------------------------------------------------------------------DLTNLQNSLPHPLLMVDDQ
YQILHHNAACKEIFKYETSLG-GQR---LNSLSGNPDLPNLVSIVEEARNTDSEINRQI----A--GEKSYWMSCTPCKDADGVQKGAVIVFWNNTELLD
TYRRLDKSVANAQQGIVIVDAIKPSMPILYTNKAFTRITGYSKEEVFGRNCFLQMNYRKDGSISPIIWKKVEETGHWQGEVEGATDDKDL-SLLISVSRV
NGKDILGDQYVLQATDVSLLKQKERQLQKLATYDQLTGLPNRRLFNTRLKEAIARAERADKTFALLFMDVDNFKRINDTLGHKIGDEVLLHFTETVREMT
RENDTFARMSGDEFVLILDGVEDTDAQHFSQRIIDAISHPYRTEDGDLLLSVSIGVALYPTDGYIPETLLRNADMAMYRAKQSGKAQVAFVEPGRSNELW
QQMQIEGELRKGLIDGGLYLVYQPIFDASDGNLYGFEALIRWEHPNFGSLQPDEFLPLARSAGFGRDLDTWVFNEFLKQYADWVHQCPAAKQYAINIDPS
TLLNHSQISALLAELD-NNLNRPRLTFEITENALINRSEELVTGLQSLHDMNTTIAIDDFGNGYSNFGYITDFSIRQIKLDRSMIQDIEKDPDKLKRMRA
IIRMLDEIGYKTVIEGVETQQQLALLNDAGHNFVQGFHLSTPLDAGGAGRLIEETA----
>tr|W5YLJ7|W5YLJ7_9ALTE Uncharacterized protein OS=Marinobacter similis GN=AU14_10985 PE=4 SV=1
---------------------------------------------------------------------------------DLLNIQNSLPHPMLVIDQD
CRIIHHNTACHEIFKFEYGLQ-GQR---LTALTTEYELPSLSKIIDEACKRGKEEFIQI----T--GEQKYWLTVTPYKNPDGNRDGAVLIFWNNTELME
TSQRLHESISNAQQGITIADATSPTLPIVYANDAFTKITGYTKEEVFGRNCFLQVNYRKDGDLSPIVWRTVKSQNRWQGQLLLQSKPKPI-ALLVSINRV
RGPDNIDPHYVMLASDITKLKQREQELKQLATTDPLTNLPNRTRFRERLQEAVARARRKDERFALMFLDMDNFKRINDTLGHKTGDMVLKYFAKTVSGMI
RENDTFGRISGDEFVLILDSLSQSDAHQFAQRIIETISQPYRLDSGDLLLSASVGVAIYPEDGDSAELLLRNADLAMYKAKQRGKAQVGFVDPERTGVLW
EQLQLEAALQKGLIEDGLHLNFQPIYKASDISVDGFEVLVRWQHPELGQLPPDRFLPIARSAGFAKHLDLWVFRRFLAHYAEWHKKHPQVNRFAINIDPS
SLLTRSQISALLSNLD-DTVNRPKLTLEITEHGLIDHNDELRQGLDSLQAMDVRISIDDFGSGFSNFVYITDLSIQEIKLDRSIVSEIESKPAKLKRLRA
IIGMLNEIGYHIAIEGIEHEAQLDLLTDAGHDCVQGFLLSRPLSADQAETVISTRA----
>tr|B8KPY2|B8KPY2_9GAMM Diguanylate cyclaSe/phosphodiesterase with PAS/PAC sensor(S) OS=gamma proteobacterium NOR5-3 GN=NOR53_559 PE=4 SV=1
---------------------------------------------------------------------------------DLENLLNSSDSATLIVDRE
RRIRRFTPNLKELMRLRDTDV-GRD---VGDIFRLFDDAEFLNDIARVVSGELPADVEI----NLSDDRQLLRRILPYDLPDTKLAGAVINFIDVSELQR
VRARDRQRALALLDAAAPVFGRTLEGAITYWNKCAEELWGYSEEEALGKNAELL------------QWKTI--------TLPIRKRDGSQVWIEHRFRIM
YSSDSKILGYRGTMRDVDEVHKLEKEARDLAFKDPLTNLPNRRMIAVKLDEARTVSNRTYQYGALVMLDIDHFKRVNDTDGHGVGDELLVEVAARLRQRL
RSFDTVARVGGDEFLMILNALGQQEASLTASRICNEIRADITGASTSHHVTGSFGVALFVGDKETAETLLKQADMALYSAKDNGRNRVKLFDPKMQADVD
RRMASETALLGAQESGDLIMYYQLQTDAQGQ-AKAVEALLRWKKPDGSMASPMEFMDVLEDQPLVSNIGHWVINTCFAQLKQWEADPDLHNDISINISAG
YLVNDSFTKELGQLIESNSVDPRRIILELTENALLVESDRISTLMYKLSARGFRFSLDDFGTGFSSLSHLRDLPLAQLKIDQSFVAGLPDDLNCQSIVKS
IVAVGQALNLEVVAEGVETRAQCDFLQSLGCDLYQGYLFAHPVPADKIKLF---------
>tr|Q609I8|Q609I8_METCA Putative methyltransferase CheR OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN=MCA1246 PE=4 SV=1
---------------------------------------------------------------------------------DLNNLLVGTDLAILFLDCD
LNIRRYTPACNRLMHLIPSDI-GRP---FADIVHHFEDDELFTDATDVLRGAEPKSREI----LDQQGAWYLRKILPYRSRNCCVEGLVITFGEVTSLKQ
AEHELIAQALR-------------------------------------------------------IRQKVLADGHWKGELTHVDRQGRERTVATHWELY
RDAEGVPRAIVEVNNDITERNQSRHYLDYLAYYDPLTQLPNRFRFQQRLEQAVSQALAGGKRLGLLFLDVDRFKLINDSLGHEVGDSVLLEISRRLEERL
GPGDTLARIGGDEFAVLMEDLDDGYASRFALAAIEAVKTPVVLDRHELFVSLSGGISLFPEDSRDADGLLRSADAAMFLAKEKGRGNYEFFTPDLNRRAN
RLLSIETRLRKALENGELELAFQPQMSLQSG-VTGAEALARWNSRELGRVPADEFIQVAEDSGLIVPLGKWVIRTVCQTIAGWQRSGLKPVRIAVNISAR
QFREPNFVRLVADTLTETAVDPTLLELELTERLLLQDVDTVVRTLLELKRTGVSFSMDDFGTGYSSLSYLRRLPLSHLKVAREFVPWGADDCNNLSISRA
IVSLAKSLELSCTVEGIETEAQLDCFKTLGCDQAQGYLISPPLPPGEFEDFLRRPL----
>tr|N6W1W7|N6W1W7_9ALTE PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Marinobacter nanhaiticus D15-8W GN=J057_02430 PE=4 SV=1
---------------------------------------------------------------------------------DLDNLLRSITSATLFIDSS
FHIRLFTPNCKQLFNLVDTDV-GRP---LDEIKFKVQDDYLLQDAATCLETLESLESEV----TANGNYWHLRRISPYRTHEDRIDGVVITYTDITRLKN
AQGELSEMALEFELSAVPFFVMGDDGYFSRLNPAWSRIFNWHLNELYERPYDFIARFCARDWEIQRLVENRTVAVP--EPALLVRKDGASIHVDASVSPV
YNNKGDLLGAVAVFFDVSYARELTKRVRHRACHDDLTGLVNRGEFENRLATVVASARDDGKVHALLFMDLDRFKIVNDTCGHLAGDELLRQIAGELQVHV
RQRDTLARMGGDEFALILENCNAEQVFRVADDMLAFMHNFRTWEDKTFQVGMSIGIALIDEHAASVRQVVHNADNACYMAKEGGRDRAYIFNQENEDDLH
HKTYMYTKVSQALEDDDIELVAQPIVALEDGQGNHFEVLSRLKGDEGETIPPSKFINAAERYNLMPRLDRHVVRKVFQWLSEN--PAIIELICSINLSVS
TLGDDRFPDFLNDLRKQYHVPSHKVCFEITETMAIRNLTKTIELANEFRKQGFLFSLDDFGSGFASYHYLRQLPVDFLKIDGEFVRKIVEDPMDEAMVRS
MNEIGHIMGKKTIAEFVETQAVFDKLKEIGVDYVQGFAIGRPDDLENEGKKDNGAG----
>tr|I0IN64|I0IN64_LEPFC Putative signal transduction histidine kinase with CheB and CheR activity OS=Leptospirillum ferrooxidans (strain C2-3) GN=LFE_1
---------------------------------------------------------------------------------DLENLSVSINTAILVVSRD
LLLRSFTPMAGKLFNLSVLNG-AKV---LERIGCEVDCPDMESFVLKVIREVQVSEREI----RDHEGRVYLLRVRPYMTDDNRIDGAVLVFFDITTIKE
HELEISRREIEFNAAPVGFSVLNSDFRIVMANQSFLKMFEYSSGEILGRSVDLELSERMESCISRRMWETIRSGRIFEGRIVDRRKDGSFYTVETVIIPM
MDSDGTITHYVGVQKDV---------------RDSLTGLLNRTSLNDRLHMEIERNLRLKSSSIVFFLDIDGFKTINDTMGHEVGDRLLQEMGLRISSVI
RTSDFVARWGGDEFVLVMTDVVDATVAPFAEKLLSVISNPLEIDGTVIHVTASVGIAISPRDSASVGDILKKSDIAMFQAKAHGKNTWKIFDLAMESEIR
EQYERERALHEAITSGQFRLFFQPQINVLND-IVGVEALVRWDHPTEGLVLPGRFIPLAERTGLIIPLGEWVLEEAFRTIERWMKAGFSRIRVGVNVSAS
QFWHPPFWENLERHFEANPELAFWLDLELTESVLLKDPAEAANLILKMRMLGVRMTLDDFGTGYSSLSYLSELSLDAIKIPQEFVIPMHDSLPKTNLVKT
IVQMARILNLDLVGEGAETMEDVEMLSLFGCAVIQGFALSKPLPLADVESFICEKS----
>tr|W9V9N8|W9V9N8_9GAMM Cyclic di-GMP phosphodiesterase Gmr OS=Nitrincola sp. AK23 GN=gmr_2 PE=4 SV=1
-------------------------------------------------------------------------------ADLASSVLSRHSAPILLIDPS
GQIVDANQSASRFYGLSLDRLKNYKI-QDFNVLDEDAIR---QEIARAASEQRNY-FVFYHRLADQSVRAVEVYSSPILETSFQSLVILGLYLSIRRRQE
AENQLQKLTMAVEQSPDSIVITDLKGNIEYVNSAFEEKSGYSFRETVGQNPRFLHSGKTDAQVYKDMWETLIDGRIWRGEFVNQRKNGKEYTELATIAPV
RDKAGVVINYLAIKRDITEQKMADEKIHQLAFFDSLTGLANRSLLFERLSQALTSTARLQHQEALLLINIDRFKMINDAHGIGFGDELLKVVSLRLVNLL
RVGDTVARTAGDEFAVLLPDINQAGALVVAEKIHAALRATFDVQGEAFALTVSIGITTFPDDQDTSGTVFRRAETALHRAKSSGGNQTAFFETSMGEAAS
SSFRTEQELRSGIQNNELCLYLQPQFNYA-RQIEAAEVLVRWQHPSRGLLYPGAFIPIAEESDLIVDLGKWVFRESCRLMVSEYSNGRV-LPLSINISPK
HFTKKNFVEWIDHIVSETGVDPNWVVLEITENLFIKDFDTVVVNMQALVERGFRFSIDDFGTGYSSLVYLKRLPIHELKIDKAFVQEAPFNHSDAVLVET
LLSVAKHMNLKVVAEGVETQAQADFLQARADILYQGYLFGRPEPAAYWIENWR-------
>tr|U1L568|U1L568_9GAMM Chemotaxis protein CheR OS=Pseudoalteromonas spongiae UST010723-006 GN=PSPO_08404 PE=4 SV=1
-------------------------------------------------------------------------------NTEFEQIFDDHTAVMLLIEPS
GKIVKANQAAADFYGYSSQTLQSKTI-QEINLFTAEQVA---EERKNAHRQKRNY-FIFRHQTATGDIKTVEVYSIPIIKTKITL----ALFLDISKQKQ
DEKQLRLSSTVFRTANEAVMICDKNYRIQAVNEAFTEITGYHSDEVLNKTPDILSSDLQTEPFYANMQHQLDENNQWQGEICNRRKNGELYYEWLSITAL
RDNNGEIDAFVALFSDITKRKTAENKIYQQANFDSLTGLANRNLFSDRFEQALNKAQREHSFLALLFIDLDGFKHVNDTLGHSQGDTLLQQTATRLSSTL
RKSDTISRLGGDEFAVLIASDNNFKVDRVAHKIQAAIAAPYQLDNAQGFVSASIGITTYPNDGKDVETLMRKADSAMYKAKAKGKNNFQFFTAEMDEKAQ
KRRTLEGELRTAIDNQQFFIDYQPIFDAKHNIIYACEALVRWHHPTKGLVSPDQFIELAEEIGVIANIGEFVLEQACVTAAKWDEYKNA-PGISVNISTI
QFQRDDFIATIKSTLEVSGLPSNKLILEITESLLIENDKKTIAQLTMLANLGVKIAIDDFGTGYSSLSYLKKFPVHKLKIDRSFIKDVEHNAESQALTKA
IIAMSKSLKLEVIAEGVELNAQMHWLTASDCSLIQGYWFAKPVDALTIKELLA-------
>tr|A0A0A7EKU0|A0A0A7EKU0_9GAMM Uncharacterized protein OS=Pseudoalteromonas sp. OCN003 GN=OM33_19625 PE=4 SV=1
-------------------------------------------------------------------------------NTQFDKIFEDHTAVMLLIDPS
GDIVKANDAAANFYGYPLDALENKSI-QEINLFTKEQVA---EERKNAKLQKRNY-FIFRHQIASGEVKTVEVYSVPLINAKVTV----ALFLDITKQKQ
DEKQLRLTSTVFQTATEAVMICDKHYKIQAVNEAFTKITGFDSHEVLNQTPEILSAGLKNESIYKNIQHQLDENNQWQGEISNRRKSGEIYYEWLSITAL
RDNSGEIDAFVALFSDITKRKKAESKIYQQANYDSLTGLANRNLFLDRFEQALNKAERDHSYVTLLFIDLDGFKHVNDTLGHSQGDLLLKQTAQRLSATL
RKSDTITRLGGDEFAVLISTEKCFNIRKVAGKIQTAIARPFELENAQGFVSASIGITSYPNDGKDVETLMRKADSAMYKAKANGKNNFQFFTAEMDEKAL
KRRALESELRLAIEKQQFIVHYQAIFDTEKNHIYASEALVRWQHPEKGLLSPFHFIELAEELGLIADIGEFVLNTACDCAASWKSFDNA-PSISVNISSM
QFQRDGFLESIENALNKSGLPAEKLILEITESVFIENDQKTITQLTKLADSGIKIAIDDFGTGYSSLSYLKKFPVNKLKIDRSFISDIEHNHENQALTKA
IIAMGQSLKLEVIAEGVETRDQMQWLKDSECALIQGYWFAKPSDHEDFKTLLF-------
>tr|A0A0C1M113|A0A0C1M113_9GAMM Diguanylate cyclase OS=Pseudoalteromonas elyakovii GN=QT15_00665 PE=4 SV=1
-------------------------------------------------------------------------------NELPYYTFSNHSAVMLIIEPS
GKILDANKAAAAFYGYSEAVLESKVI-QDINLFTAEQVA---NERQAALNEGRNY-FIFQHQTADGSVKTVSVHSTPFIKQAILSMAVLMTVLDITEELE
NEREQRLASTVFATTTEGVLVSDKHNQIQMVNRAFSEITGFGMDEVIGETPAILNSGRHDERFFNALYDDLVNRGHWEGEIWNKRKNGEIYPSWLQVSAV
FNEAREIDMYVALFSDITSRKRNEQLMWQQANFDSLTGLANRHHYHVKFDLALKRAAQLEERFAICFIDLDRFKAVNDTLGHHIGDLLLKEAANRINECV
RSSDTVARLGGDEFALLLQDISSSDLELVATKILRALANPFHLEGHEAYVSGSMGITLYPDDGTDRKILLRNADSAMYKAKEHGRDCFQFYTSAMHQHAK
ARSVLESALHKALSNRELSLVYQPIFSQLGGDLVGCEVLLRWKSELLGHVSPDQFIPVCEELGLILPIGEWVLYHACSQVKAWDNYGRP-LFIAVNVSSI
QFKRQDMVELVRKVLRDTKLEAKYLTLEITESVLVENSDKILSQLKALREMGVELAIDDFGTGYSSLSYLKRFPLSKLKIDRTFIRDLPEDEEDKALVSA
IILMAHKLNLRVIAEGVETPAQCMFLKNLLCDMTQGYFHSKPVAQQEFEANVL-------
>tr|U1KX15|U1KX15_9GAMM Uncharacterized protein OS=Pseudoalteromonas rubra ATCC 29570 GN=PRUB_03476 PE=4 SV=1
-------------------------------------------------------------------------------PFLPVSAFEQHSAVMLLIEPS
GNIVQANEAAARFYGYSQARLETMQI-QQINQFTPQQVE---QERMSALSEGRNY-FIFQHQLASQEIRTVSVYSAPFLKEAGGSILVLVLFTDISKRLA
GEKEQRLASTVFATTSEGVLVSNRDNQIQMVNQAFTDITGFSAAEVLGNTPSIFNSGRHDAAYFAQLYDALTSRGHWEGEIWNKRKNGEVYPSWLQVSAV
FDAAGEIDMYVALFNDITSRKRNEQLMWQQANFDNLTGLANRHHYHTKFDLALAQAKQKQTRLAVCFIDLDRFKAVNDTLGHHIGDQLLIEAANRIRECT
RNSDTVARLGGDEFALLLPDMAKSDMEKLATKVLHTLSEPFFLEGHEAFVSGSMGITFYPDDGADRKVLLRNADSAMYKAKEHGRNCFQFFTSAMHEHAK
ARSALEGALHRALTNRELYLAYQPIVGQ---KRLGCEALLRWHNPQLGLVSPADFIPICEELGLIITIGEWVLYQACAQAKSWTQTGQP-LFVSVNVSST
QFKRQDIASLVAKVLKETGLAADALTLEITETVLADNSGHIQRQLESLRGMGVGLAIDDFGTGYSSLSYLKRFPLSKLKIDRAFIRDLPEDEEDRALVSA
IISMAGQLNLTVIAEGVETPAQLAFLQSLGCDYTQGFLHAKPADAAQFEAFIH-------
>tr|L8DAU4|L8DAU4_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudoalteromonas luteoviolacea B = ATCC 
---------------------------------------------------------------------------------------------MLVIDPS
GDIIDVNDAAIAFYGYDKAQFTQLKI-QSINQLSAEQVA---AERIEAANQGRNY-FIFQHKLRSGEVRTVQVFSSPFIETALGASIILAFMSNIRARLD
AERELRLASTVFETTHEGVLVSDKQNRIQLVNRAFTDITGYEQHEVLGQTPDIFSSGRHDTAYFTQLYDTLNTQGHWEGEIWNRRKGGDIYPSWLTVSAV
FAETGEIEMYVALFNDITSRKKNEQLMWQQANFDNLTGLANRHHYHNKFDQEIQRALREGSRLAICFIDLDRFKAVNDMLGHHIGDLLLVEAANRIRGCT
RSSDTVARLGGDEFALLLPDINSVDIEKVASKVLSSLHSPFNLEGHEAFVSGSMGITIYPDDGTERKILLRNADSAMYKAKEHGRNCFQFYTSAMHEHAK
ARSKLESALHKALINKELSIHYQPILNRH-GQVCGAEALLRWFSPLLGQVSPAKFIPVSEELGLIVAMGEWVLYQACAQAKSWEDQGED-FFISINVSST
QFKRQDIASLVAKVLRDTGLAPQYLTLEITETVLADNTHHTLHQLQALRELGVELAIDDFGTGYSSLSYLKRFPLTKLKIDREFVRDIPDDPEDCALVSA
IISMAGNLNLKVIAEGVETQAQLSFLHSIECHYTQGFLHSKPISSSHMDALLE-------
>tr|V4JF00|V4JF00_9GAMM PAS domain S-box/PAS domain S-box/diguanylate cyclase (GGDEF) domain protein OS=Pseudoalteromonas luteoviolacea 2ta16 GN=PL2TA1
-------------------------------------------------------------------------------QTLPSEVFDNHSAVMLLIEPS
GKIVRANQAAADFYGYNKAQLEALHI-QEINQFSPQQVE---KERLSALNEGRNY-FIFQHRLASGENRTVSVYSSPFIKHAVGTTLLLGWGFNITQRLA
DEKEQRLASTVFSTTSEGVLVSDKDNCIQMVNRAFTDITGFTGPEVMGKTPAIFNSGRHDTAYFTQLYDALSSRGHWEGEIWNKRKNGEVYPSWLQVSAV
FNQHGDIDMYVALFNDITSRKRNEQLMWQQANFDNLTGLANRHHYHAKFDIALGQAQRKQTRVAVCFIDLDRFKAVNDTLGHHIGDLLLIEAANRIRECT
RNSDTVARLGGDEFALLLPDMELSDMEKVAEKVLKALSAPFHLEGHEAYVSGSMGITFYPDDGEDRKVLLRNADSAMYKAKENGRNCFQFFTTAMHEHAK
ARSQLEGALHRALANQELRVVYQPIVGD---NRLGCEALLRWHNDTLGEVSPVDFIPISEELGLIMAMGEWVLYQACAQARAWNKTQQP-FFVSVNVSST
QFKRQNVVALVEKVLRDTSLPAECLTLEITETVLADNSDDIERQLEQLRVMGVGLAIDDFGTGYSSLGYLKRFPLSKLKIDRAFIKDLPDDEEDKTLISA
IISMASKLNLIVIAEGVETPAQLALLQQLGCDYTQGYLHSKPSSAAEFEAFLL-------
>tr|A0A063Y5L3|A0A063Y5L3_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Nitrincola lacisaponensis GN=ADINL_1449 P
-------------------------------------------------------------------------------GPAFDQVFSESGVMMLLIEPS
GRIVEANKAAAEFYGYPLDQLQQMTI-QQINTFTPEQVA---RERAAAESAGRNY-FIFRHRLADGEIRTVEVHSRPYIQRSVIQGLVILLLI--LAGWA
DGKPI----QPFGYSLEGTPCADRMIRAQGIQQAYPD------DAL---------------------LAELGA-EAYIGSLLDKRQQPVGLLVALSRQPM
HSADTLMQLYVDRVSAEMQRSEVEQQLAQMAHFDPLTSLPNRTLLADRLKHAMAQALRHEQMLAILFIDLDGFKAVNDSHSHAVGDQLLVSIAARMKQVI
RDEDTLARLGGDEFVAVLQHLHSNDSVKFLNRLLTVISEPVLLDDLEFSISASIGVVFYPQQEGLADQLLRQADQAMYQAKQAGKNRYHFFDVERDRALR
DQHEGLLRIRQALEEGELELYYQPKVNMRSREVIGAEALIRWNHPERGVLPPASFLPLIENHVLAIDIGYWVLNTALDQILSWREQGIH-VPVSVNIDAI
HLQHPGFVDQLASALSRPGIQPFDLQLEILETTALDDVKQVSGIMLACQRLGVGFALDDFGTGYSSLTYLKRLPAELLKIDRSFVRDMLDDPEDLAILDG
VIRLAGAFQRQVIAEGVETQAHCDELLKLGCEWGQGYAIARPMPASSLPGWLA-------
>tr|A0A0A8UQX6|A0A0A8UQX6_LEGHA Putative Diguanylate cyclase OS=Legionella hackeliae GN=LHA_0858 PE=4 SV=1
------------------------------------------------------------------------------TLKGWAALVNALQVGVIITDNE
SVIRYINVRAAEIFQRNCQELIGSP---F-GFTLSKNED---------------T--EIEIIHPDQSVT--IAEIHINQGFWLDRKSWIITLQDITERKH
KESELEVAARVFSSSCEGIIITDIDGRMIDVNTGFEHTFGYKKEEAIGKNVSLIKSGMQPPEFYQHMFSCLKKNGSWQGELWDKRKDGKLVPIVLTISSI
KNVNNETVFYVGLLHDISIIKKQEQELRYLAHFDPLTNLYNINYITAELEISIKHYKTSGTPFSLAYVDIDRFQDINKQFDTHIGDIVLKKFGKNMKRFI
GEQGLVARVSGNTFVILVNQYHAKSAHIFFEKLMKTINKKIRIKKNDIYISCSLGYVIYPLENTSSGQVLRQAEAAMIESKIKGGSQATEYNIDEVIEQK
YRYHIISEVTHGINANEFAVFYQPKVNMKTGEILGAEALIRWHHPQKGLCYPEYFLPYVENNEVMNRLSSLIFDEVFNQLEEWLKQGID-LRISINVSAH
ELQQENFFNEIKTKMEQYNRLNRNIELELLESAAVRDIKSVRKIISQFHEIDLRISLDDFGTGYSSLSYLRALQVDAIKIDQSFINEISSSPKVIAIIDS
ILHMAKRFNQSVIAEGVDSLEKGILLLKLGCVEGQGYFIGKPMPVSEFQSWMESWKAPP-
>tr|Q5ZWH1|Q5ZWH1_LEGPH Sensory box protein (GGDEF domain/EAL domain) OS=Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 
------------------------------------------------------------------------------TQNFWYQLVEKMAIGVLVINNE
GQILYANDYAVQLFGAIRTELIGTN---F-LYPMAADET---------------Q--EVEILKSSNEIL--TAHMTVRKSIWENRQVWIISLFDITELKL
KEKLLKISSKGISSAFEGIIITDSEGTILEANQAFMKMTGYTEQEVIGQKPAIFQSRKQNEKFYKELWKILAEKGQWSGELWAKKKNKKLFPAFLAISSV
KNSEGDVINYIGYYHDLTLIKKQEQQIENFKYYDYLTGLPNKFLLTQRLQMLISGLSEENKELIVFNIRVFDSNSSLLDFPPNIRDKIILEVVNRIDRTS
PKKMFYSRIGLGEFIVIYFIKSREVMASIAQRMIEKLACPYYIDHQTIILQTIIGLTAYYKNAFSAEDLLQQSEIARHKAQINGVNIFEFFDPQVEERII
EFNKRIESVSKAMQLNELKVYYQPIVELNTAKVVGLEALLRWQHPEKGLLLPKQFLSDLNNHPLSLQIGDWVLHQVLHQVEELLACNIK-IPINVNVSAY
QLQHPNFVKKLFDTLARYNVPHRLLVLEILETEAIEDLTLVSQIIAECKAKGINFSLDDFGTGYASLTFLKELSTSEVKIDRSFIINIFDNPKDLAILKI
IIESCKVIGRTLIAEGVETVAHGKLLELLGCHLIQGYAIAKPIPPAKLIIWIKNWHLGP-
>tr|A0A0C9PDY2|A0A0C9PDY2_LEGPN Gmr_3 protein OS=Legionella pneumophila GN=gmr_3 PE=4 SV=1
------------------------------------------------------------------------------TQNFWYQLVEKMAIGILVINNE
GQILYANDYVVQMFDVPHTELVGTN---F-LYPMAANET---------------Q--EVEILKSSNEIL--TAHMTVRKSIWENRQVWIISLFDITELKL
KEKLLKISSKGISSAFEGIIIIDPEGTILEANNAFMKMTGYTEKEVIGQKPVLLHSRKQNEKFYKQLWKILTEKGQWSGELWAKKKNKRLFPAFLTISAV
KNSDGDVINYIGYYHDLTLIKKQEQQIESFKYYDYLTGLPNKLLLTQRLQMLINRLSEENKELIIFNIRIFDSNSSLLDFLPNIRDKIILEVVKRIDRTS
PKKMFFSRIGLSEFIVVYFIKSREVMASIAQRMIEKLSCPYHISHKTIILQTIIGLTAYYKNAFSAEDFLQQSEVARHKAQIRGINIFEFFDPQVEEQII
EFNKRIESVSKAIMLNELKIYYQPIVELSTAEVAGLEALLRWKHPKKGLLLPKQFLSDIDNHPLSLQLGDWVLHQVLEQIEKLLACGIK-IPIHINVSAY
QLQHPNFVKKLFDTLALYSVPPHLIMLEVLETQAIEDLILVSQIIAECKTKGVNFSLDDFGTGYASLTFLKELNTAEVKIDRSFIIDIFDNPKELVILKT
MIEFCRVIGRTLVAEGVETIAHGKLLNLFGCNLIQGYAIAKPIPATKLIPWIKNWKLAP-
>tr|A0A098GAM1|A0A098GAM1_9GAMM Putative Sensory box protein (GGDEF domain/EAL domain) OS=Legionella fallonii LLAP-10 GN=LFA_3194 PE=4 SV=1
------------------------------------------------------------------------------PEGNWQQLVSALADGVIISHHD
GTILYVNQHAAELFGRSASSFIGEN---F-LYPLAANET---------------Q--EIDIIKPNGQVL--TAEMNVKLGAWREQQAWIISLRDITDKKR
KMEQLEIGSKVFNHAHDGIMVTDAHFNLVDMNQAFIDMTGYSKKELLGRNTKIFRSDLYEVEFYKTMRSDVKKEGYWTGEIWGKHKNGSTFPVYLTMSAV
KNRDNEVINYIGICHDLILLKKQQAIITRMKYYDPLTDIPNQYFLSEHLGSLMSENSPLGASLIIVYLALDGLNSNNKLLDEQKKDNVVIGIAHRLASVL
PKDILLARVSYSDFIAVFKNVVNEDITPAIQSVIEECGKPYEISKNKITLKINIGLTSYPQEIIYPEELIRQSHFAAYEAKFSGENQYKFYDKSLELQKI
QNNQQIRDLRIAMTQHQLEVFYQPKVDMQTGKILGAEALVRLRHPEKGTLGPDSFLPEVFKHPIYAELGEWVIHQVLADLEKKLIAQDI-YPISINISPY
HLTQESFLNDLKEILAEHKVKSEFIELEILETEVLSNLSQVKKLINECKKIGVLFALDDFGTGYSSLTYLRELSANKVKLDQSFVRDIINKSENIVILKA
CIDMCKLLKREVIAEGVETIAIGKLLLYLGCTNAQGYAISEAMPVDELCEWSKNWHSFP-
>tr|I4N873|I4N873_9PSED PAS/PAC and GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. M47T1 GN=PMM47T1_04104 PE=4 SV=1
------------------------------------------------------------------------------SRDRYMDLYENAPVGYLTLNTQ
GLIEAVNQTGETLLGCSRDHLLNRR---F-ASRVASQER---------------DHEECELTLR---CV--RHDNNP------PM--VRVSLTDLTARRN
LESRLNLAASVFTHAREGIMITDASGIIVEVNDAFSTITGYSRHEAVGLNPRFLASGMTEPAYYAELWRCLLLDHHWQGDLWNRRHDGETFATRQTITAI
LDPHGRVQNYVSLFTDVTELHEHQRQLEYIAHYDPLTHLPNRVLLASRMQQAMTRALGLGSKLALAYLDLDGFKAINDLHGHDAGDRVLTTVARRMKHTL
RDACTLARLGGDEFVALIVDLDQYDSAPMLERLLAAASDEVQIGELAINLSASIGVSYYPQEEISADQLLRQADQAMYQAKLAGKNRFHVFDAQHDLDLR
GHNARLDRIDRAIREQELRLYYQPKVNLRTGEVVGAEALLRWQHPEKGLLMPDSFLPLIESNSLSEVIGDWVLESALSQVQAWQHAGVR-IPVSVNVGAR
QLQHPDFVANLLERLAAHDVDPRMLMIEILETSALEDIEGVSHTLRSCAAMGVRFALDDFGTGYSSLSYLKRLPVAQLKIDQTFIQGMLDAPEDISILQA
ILGLASAFRREIIAEGVDNAVQANRLLQLGCELAQGFGIAQPMPPEALPAWIARWHANP-
>tr|N6YEP1|N6YEP1_9RHOO PAS domain-containing protein domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thauera sp. 27 GN=B447_1187
------------------------------------------------------------------------------------------------FAEA
GA-----QPDVVLLD--------L------------SLP---------------DSAPIIVLSG---AF--GADDYLPKGGDSEV--LRRAIRYARLRHQ
RDADARLAAAVFAHAREGIIVTDAQGNIVEVNEAFTRITGYAREEVLGRNPSLLKSDRHDQAFHAAMWKSLHDKGHWYGEVWNRRKSGELFAELLTISAV
RDARGAIRHFVGLFSDITVQKEHERQLEHIAHYDALTALPNRVLFADRLHQAMARATRSGQRLAVVYIDLDGFKAVNDTLGHDVGDKLLMALALRMRKTM
RDCDTLARLGGDEFVAVLSDLPDESCRPLVRRLLATAAEPVEVNGQLLKVSGSIGITLYPQRDVEADQLLRQADQAMYQAKLAGKDRYHLFDSDQDYDLR
SHHESVERIRQGLLRDEFALHYQPKVNMHSGELIGAEALVRWQHPEQGLLPPDRFLPAIERHELGVQLGEWVIDSALSQIAAWQAEGLR-VPVSVNISAN
HLQRADFAERLYLLLSLHEVAPDQLQLEVLESSALADMNRVAETMATCTRMGVSFSLDDFGTGYSSLSYLKRLPAAELKIDRSFVRDMLHDADDLAILDG
VLGLARAFRRRAVAEGVETEAQGELLLRLGCECAQGYGIARPMPPSALPGWAAGWRPPL-
>tr|H8Z2C0|H8Z2C0_9GAMM Diguanylate cyclase (GGDEF) domain-containing protein OS=Thiorhodovibrio sp. 970 GN=Thi970DRAFT_01790 PE=4 SV=1
------------------------------------------------------------------------------TREHWRAFYGEPRPCLVDLIVQ
ER--------AGEIG--------HF---Y-DS-HEARPG---------------QAA-------SELYL--SIDAGLIRDETGRVIGAVETLRDMTESKL
ADRKLRLVASVFEHSQEGIVITDPKASILDVNASFTRVTGYSREEALGQTPALLKSGLQEASFYQDLWSRLHETGQWQGEIWNRKKSGEVYPEILHINAV
TNRAREVTHYVGMFIDITDLKNTQQRLEALAHYDALTDLPNRVLLAERLHQTLSNAKRFERLVAICFLDLDGFKLVNDRHGHEIGDRLLIEIANRLRGTL
RGGDTVARLGGDEFVLLLAELDNEEVEMILQRVFDAVAKPFRTNGIDLGVSASIGVTLYPFDDSDPDTLLRHADQAMYLAKQQGRNRYHLFDQDAARELR
DQHRELDRIREALQHGEFRLYYQPKVNMRTGEVVGMEALIRWQHPERGLLGPMEFLPLVEKSQMIVDIGEWVLHEALGQMEQWALNGHP-MAVSVNIAAR
QFQHIDFVARLRAILDEHDVPAHLLELEILESTALEDVDMMREVMAACQAMGVTFALDDFGTGYSSLSYLKQLPAETLKIDQSFVRDMLDDQEDLAIIEG
VIGLASAFNKRVIAEGVETAEHGVLLMHFGCDCAQGYGISYPMPAAEVAGWTRAFTPDW-
>tr|W9V5L4|W9V5L4_9GAMM Diguanylate cyclase OS=Thiorhodococcus sp. AK35 GN=D779_2188 PE=4 SV=1
------------------------------------------------------------------------------TREHWRAFYDAPRPCLADLIAQ
GR--------DGDVR--------KF---Y-SP-NDVVSE---------------WSA-------AELYL--ALDASPILDASGELIGVVETLRDMTDRKR
TESELRLIASVFDNSQEGILMTDPDGRILDVNGAFTRVTGYTREEVIGQTPAILKSGVQESAFYKEMWRCLGETGQWQGEVWNRKKSGEVYPEILHINAV
TGACGRVTHYIGMFTDITDLKSTQQRLVSLAYYDALTDLPNRVLLAQRLHQAMSRAKRSERLVAICFLDLDDFKVVNDRYGHEIGNRFLIETANRLLGCL
GNGDTVARLGGDEFVLLVADLISEQLEGILGKVFEAVAAPFDIGDIDIGVSASVGVTLYPLDDSDPDTLLRHADHSMYQAKQLGRNRYHLYDLDAAKDLQ
TRHRELERIRQALQHGEFRLHYQPKVNMRSGRVIGLEALIRWQHPEQGLLSPAAFLPQTEHSPLIVDIGEWVLHEVLAQMAVWALEGYE-LPVSVNIAAR
HFHHIDFVQRLQEILSEHEVSPHLLELEILESAALEDVLVMREVMAACQGIGVSFALDDFGTGYSSLTYLKQLPAETIKIDKSFVHDMLDDQEDLAIIEG
VIGLAGVFRKELIAEGVETAEHGLMLMRYGCDCAQGYGIGRPMPPEAVAEWVRGFEPDW-
>tr|G2DZG9|G2DZG9_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_1432 PE=4 SV=1
------------------------------------------------------------------------------TREHWRAFYEEPRPCLADLVVQ
DR--------GGELP--------CF---Y-SM-HDVRFE---------------SAA-------AERYL--ALDASPICDADGHLIGVVETLRDMTERKR
AESKLQLIASVFDHSQEGILITDPNGRILDVNAAFTQVTGYSRDDVLGQTPALLKSGLQESAFYKEMWRGLEKTGQWQGEIWNRKKSGEVYPEILHINAV
SGNDGAVTHYIGMFTDITDLKSTQQRLVSLAYYDALTDLPNRVLLAQRLHQAMSRAKSRERLVAICFLDLDDFKVINDRHGHEVGNRFLVEIANRLLASL
RNSDTVARLGGDEFVLLVTELVSEQLEGILAKIFEVVAAPFRIGDIDIAVSASIGVTLYPLDDSDPDTLLRHADHSMYQAKQLGRNRYHLYDLDAAKDLQ
TRHRELERIRRALQHGEFRVYYQPKVNMRSGQVVGLEALIRWQHPEKGLLSPLSFLPQIEQTPLIIDVGEWVLHEVLAQMGQWLQEGYR-LSVSVNIAAR
HFQHIDFVFRLEAILSEHDVSPHLLELEILESAALDDVVLMREVMAACQGIGVSFALDDFGTGYSSLSYLKQLPAETIKIDKSFVHDMLDDQEDLAIIEG
VIGLARVFRKQVIAEGVETPEHGLLLMRYGCDCAQGYGIGRPMPAGSISHWISDFQPDW-
>tr|W0E2R4|W0E2R4_MARPU Diguanylate cyclase OS=Marichromatium purpuratum 984 GN=MARPU_07885 PE=4 SV=1
------------------------------------------------------------------------------TGEHWRAFYRAPKPCLAELLMQ
GG--------LDEIR--------GR---Y-DLSVDEVLD---------------ESV-------TERYL--GLDAGPIRDGKGRLVAVVETLRDLTERQR
AQTALQLNASVFENSQEGIVITDTSSRILDVNAAFTRVTGYPREEVLGRTPALLKSGLQDDQFYQEMWHRLREFGQWSGEIWNRRRSGEVYPEMLRINAV
KDADGTLTHYVGMFSDITDLKDAQRRLESLANYDALTSLPNRVLLSDRLHQALANAKRRDRLVAICFLDLDDFKLVNDHHGHDAGDRFLVEIAKRLVRTV
RGGDTVARLGGDEFVLLITELRNDELDLVLERTLETIDAPVEIDGIALDVSASIGVTLYPFDDADPDTLLRHADQAMYQAKQLGRNRYQLFDMEAAANVQ
HHHQELERMRRALQHGELRLFYQPKVNMRTGEVIGVEALIRWQHPEQGILAPAEFLPLVEQSSLIVDIGEWVLHEALAQLAEWSQQGHE-LSVSVNIATR
HFQHIDFVARLQAILAEYGVAPGRLELEILESVALEDVEAMRAVIAACQAMGVRFALDDFGTGYSSLNYLKQLPAETLKVDRSFVRDMLDDQEDLAIIEG
VIGLASVFGKEVIAEGVETPEHGVMLMRIGCDHAQGYAIARPMPADSMHDWLKGFEPDP-
>tr|N6Y3A4|N6Y3A4_9RHOO PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thauera sp. 63 GN=C664_13764 PE=4 SV=1
------------------------------------------------------------------------------------------------LAGG
GF-----QPDVVLLD--------L------------NLP---------------DSAPIVVLAG---AL--GADDYLPKGGDSEA--LRRSIRYAQLRHR
RDADARLAATVFAHSREGIIVTDVQGRIIEVNEAFTRITGYTRDEVLGREASLLKSDRHGPEFHAALWQSLLEKGHWYGEVWNRRKGGELFAELLTVSAV
RDARGEIRHFVGLFSDITLQKEHERQLEHIAHYDALTALPNRVLFADRLHQAMARARRGDQRLAVVYIDLDGFKTINDTQGHDAGDQLLMTLAGRMRKVM
RDCDTLARLGGDEFVAVLGDLPDDSCRPLVRRLLATVAEPVEVGGHSLQVSGSIGVTLYPQREVEPDQLLRQADQAMYQAKLAGKDRYHLFDTDHDHDLR
SHHESLERIRHGLVRGEFVLYYQPKVNMHSGELIGVEALIRWQHPEQGLLSPDCFLPVIEHHPLGIQLGEWVIEAALGQVAAWQAEGLR-VPVSVNIAAN
HLQRADFAERLYLLLSLHGITPDMLQLEVLESSALADMNHVAETMATCTRMGVGFSLDDFGTGYSSLSYLKRLPAAELKIDRSFVRDMQHDADDLAILDG
VLGLARAFRRRAVAEGVETEAHGELLLRLGCEYAQGYGIARPMPPESLPGWAASWRPPE-
>tr|A0A060NPR4|A0A060NPR4_9BURK Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Comamonadaceae bacterium A1 GN
------------------------------------------------------------------------------------------------LDAG
TV-----APDVVLLD--------L------------NLP---------------DSAPIVVLTG---QS--GAEDFLTKGADGST--LRRAVRYAMLRHQ
READARLAVSVFSHAHEGVIITDAQGLICDVNQAFSHITGYSRVEVLGRKPGLLRSGRHAPAFYQEMWATLLASGQWSGEVWNRHKNGELFVEHLTLSAV
RDGRGRIRHLVGFMLDITRQKEHQSQLEYMAHYDRLTGLPNRLLLSDRLQQAMARSHRNGLQLAVAYLDLDGFKAINDAHGHDVGDEVLQAVALQMRATL
REGDTLARLGGDEFVAIFESLHHDDSLPCIERLLKAASQCMQGDVRRLKVSASIGVALYPQPEVEADQLLRQADQAMYQAKLAGKNRFHFFDLERDIGLR
GHHVEMQRIRFALAQSEFVLHYQPRVQMRSGAVVGVEALIRWQHPERGLLAPGVFLPLIENDPLICELGCWVIDAALQQIGHWQRAGLH-LPVGVNVAPY
HLQHPNFLAQLAALLAQHEVDPALLEIEIVETSALTDLDSALAVVKGCQKLGLRLALDDFGTGYSSLTYLKRLPVQTLKIDQSFVRDMLCDPDDLAILEG
VIGLAKVFRRDLVAEGVETHEHGRLLLQLGCESAQGYGIARPMPAADFPPWLQRWSAPA-
>tr|G2E1S9|G2E1S9_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_2242 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------MHGRPTGAVGER--FDDGVRAA-VGGC
FEQCPTLAKLLFGYAREGVLVTDGEGVVVDCNDAFTQVMGHAREEILGRHARTLISGLHGTELFAAIWRELTEKDHWRGEAWSRSKDGRLFPVTLIMTAV
RDPEGARQHFLGLVSDLSGQEDQRRHLDYIAHYDPLTGLPNRILLVDRLQRAMEQVACRGTRLTVAYLDLDGFKAINDTYGHEAGDRLLVALARRMPSAL
RACDTIARLGGDEFVAVLLDLDDSIGEVVLERLRMAASDPVLLGDVVLQVSVSIGVTHYPQAEVDADQLLRQSDQAMYQAKLAGRNSDQLFDPEQAFNLM
DRHQCLARIRTALERREFVLYYQPKANMHTGEIFGAEALIRWQHPERGLLLPNAFLPPIEGHAVAVELGEWVIEAALTQLEEWHAVGLH-ISVSVNLGAY
QLQRPDFMDCLRTLLAAHRVHPSFLELEIVESSALQDIELVAQVINACREIGVQFALDDFGTGYSSLTYLKRLPAASLKIDQTFVRDMLDDPDDLSILEG
VLGLAKAFERHAIAEGVETVEHGRLLLQLGCELAQGYGIAVPMPGADLLRWVSAWRPPV-
>tr|W9VI72|W9VI72_9GAMM Diguanylate cyclase OS=Thiorhodococcus sp. AK35 GN=D779_3393 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------MDE---VP--RSADGQPTVATG--------GKCA-AWPF
LDSGPALAEAIFRNAREGILVTNAEGLVIDMNDAFGLISGYSREDILGRSLFSPASGTLGSVSIPDVWRDLVDKDHWHGEIWNRHADGRFFPGTAIIDAV
RDPQGVRRHFVGLFFELSGHEEHRRHLEYVAHYDLLTGLPNRVLLAERLQRAMLEVKRRGRRLTVAYLDLDGFKSINDLYGHDVGDRLLITLAQRMPQAL
REGDTIARLGGDEFVAVLLDTDEAVCEPILRRLLTAASDSVLAGELILQVSVSIGITHYPQAEVNADQLLRQSDQAMYQAKLAGRNGYQLFDSDQAHSQK
DRHECLVRLRAGLERNELVLHYQPKVNMRSGVVVGAEALIRWQHPERGLLSPAAFLPALEGHALAVEVGEWVIRSALRQLRVWRSAGLE-IPVSVNVGAH
QLQQTDFMDRLSMLLSAHDVPPGLLELEVVESSALQDTEQVSRIMHECAGIGVRFSLDDFGTGYSSLTYLKRLPVSSLKIDQTFVRDMLDDPDDLSILEG
VLGLARAFEREVIAEGVETVEHGRLLRQLGCELAQGFGISAAMPGGELPAWVAAWRPPT-
>tr|D5RQC4|D5RQC4_9PROT PAS domain S-box protein OS=Roseomonas cervicalis ATCC 49957 GN=HMPREF0731_3286 PE=4 SV=1
---------------------------------------------------------------------------------------------VCRTLPD
SRFTFVNAAYARAMQRGPQHLLGRR---LADLLPEEEWAAALAHRA-RLTPAPMLGHILRQRHQGGGYRWRHWVEIAAFDEHGRMLEIHSIGRDITELQD
AMQRVSESEAVVENIAEGIVLADSHGHILYANRKVVEILGWGVEELHGRHVSQIGNPLERYLRVR-----PAPVGSSGQESFARHRDGRMLRIHFSL--S
EVELDGVRHFIGVLRDNTAIHEAQQRIERLAFNDELTGLPNQRRLKEELGRLLDRPG---ARCTLLLVDLVDFSALNGTIGFAAGDRVLRTAARRIADVL
PHDSLLARFGNDRFAVLLRDVADEAGPVLAGRIAVSVEGAEGHGESGFLPPVTIGIAMAPHDDTRPDGLLEAAEIALLDAKGRAPGSIRSFMGAMRSKAA
RRFATAQGLRRALDQGGLFIEVQPRYTADQRRLTGGEALVRWRREDGCLIPPTDFVPLAEETGLIQPVTEFVFDQVMPLLARLRPGQ----RVSMNFPPA
QLARHNLTAMIAARLARQGVPGDRLGIELTESALIGGPGLLDENLRELQRLGCAVAIDDFGTGYSSLSRLRHLPIDELKIDRVFIRDAARDAAGVAFLQA
IGAMANALSLRLVAEGVETESELEQARSIGCHEVQGWLWGRPMAPDEFIALCLEGD----
>tr|A0A0D2VUH6|A0A0D2VUH6_9PROT Skermanella aerolata KACC 11604 strain 5416T-32 contig33, whole genome shotgun sequence OS=Skermanella aerolata KACC 11604 GN=N
---------------------------------------------------------------------------------------------T----GL
SLDEV----------------IG-R---SPEVLPPDD---AASVLA-HYR---TCVKRQLPTTFQEVLH--LPTGRRHWETLVPII------GGASERVE
AEQALRDSESIFEHAGVGIGYASVDGRIIDVNRTLETMLGYGREEVIGQSFKQFVHEDEISQ-------------TFQTERRFQRRDGTELWARTTASLV
RDPLGRPKYIIGLFEDVTEARRARERIHYLASFDQVTGLPNLSLFGERVTTALERPAADERIAALLAISFDRLDPIRFAHSRTAADHLMRRLVDRLRRAL
GPDDVVGRIGDDLFAVLLPNLADEEALATVKSIIATFSTPIEADGQDFLLPPVIGVSLSPFDAGNPDELVRMAGAALQRARDQGTSRFELYTPDMETHAA
RQLSLESRLRRAIDADQFELVYQPKIEVETLKLAGFEALVRWRGEDGALISPGEFIPAAEETGLIIPLGELVLRSACEQMAAWRREGLVDLPVSVNLSGR
QVSDPHLSRKALAILAHSGLPSSHLKLELTETALFRSTPGIREALLELHAAGVRFLLDDFGTGYSSLSYLKRFPIEAIKIDKSFVQGMVEDPDAASIVNA
IINMAHALKMRVIAEGVETQEQLIFLRAYRCDRMQGFLFAPPTAVADIPALVRRLA----
>tr|A0A0A1H9X7|A0A0A1H9X7_9BURK Sensory box protein OS=Burkholderiales bacterium GJ-E10 GN=E1O_26310 PE=4 SV=1
---------------------------------------------------------------------------------------------IEEFSGR
RLFDL----------------YP-S---PLIEEFRRV---VETR------------IPYAAFDHPFPFSGHPEWGETYWDLLIP---------VL---HR
ALQALRDSDTIFEDATTAIALDAETGELRDINRAMERLVGWSRVELLGRPHWVLHPPLQNCR--T-----SSP--LIETQVLT--RRGDVVDV--EIKAS
SLQCNGRRILVGFFSDITERKRQERELRRQATHDSLTGLANRLLAEEQTARLLAPPQDSDRRVAMLLIDLDRFKIVNDGLGHAVGDALLQELGARLDVAA
RSGDVVARLGGDEFMIVMRDTPGV-ATDFGNHLLETIKQPIRVGAHELTMTASLGIASYPQDGANFAEMYRNADTAMYCAKARGRNRLEHYSPEMNRRTA
ERLDLEGDLRRALERQELVLHYQPKVRLQDGSVVGAEALVRWSHPTRGMVSPMEFIPLAEETGLIVPIGQWVIESACAQIRDWMAAGLPEVSVAVNLSAL
QFQSRNLPRQIARALDANGLSARCLELEVTESVAMAAPEESIRTLAELKTVGVRIWLDDFGTGYSSLAYLKRFPIDGLKIDRSFVDSIATDPNDATIARM
VIALARELKMQVVAEGVETWEQYSFLSRARCDAMQGYLFSESILAEDFARLLTQGR----
>tr|E1JS22|E1JS22_DESFR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio fructosivorans JJ GN=DesfrDRAFT_0421 PE=4 SV=1
---------------------------------------------------------------------------------------------P--T-AA
ALIVL----------------LA-A---GLVWAVRWR---IGMPLG-RLR---DALTRSHATGRREPLPWTSRDE------IGQVV------AAYET-EN
AQRRLAEKRKTAVEATDAAMVTDRRLTVLEVNAACLRITGFAAGELHGRCARETFLAAHDATLHR-----AMLDG--SGECPGRSRSGKTLPLRLSINAL
LDD-DAGSHLVLVFSDVTKDKATEKLLKNLAYSDALTALPNRALFLDRLEREISIGTRRSRGFALLFLDLDNFKYINDSLSHSVGDQVLSLIAGRMRACL
RDEDTLARMGGDEFTVILRETTDAVAARLGEKLVDAASRPLKVEGAAIEVGASIGVALFPADGRDSDALMRNADTAMYLAKSEGGGRVRFFEPAIAEEAK
ARLELKNNLKRAIEEKAFVLRYQPIVSMATGVAEHFEALVRWMRP-DGMVPPDRFIPLAEETGLIIPIGRLVLDMAFARLRRWREEGSS-IRLAINISRN
QFQDEDFVEDLINRARAAEVDPATVVLEITESMIIADPQAAKVILGRLIVSGFRIAVDDFGVGYSSLSVLVEYPVHIVKLDKSLIKSLEYDVRARSMVSG
FIALFQRLGLEVVAEGVETASQHEFLSLAGCDLAQGWLYGKPLPPEAASALGRAAA----
>tr|W0SNF1|W0SNF1_9RHOO PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_03563 PE=4
---------------------------------------------------------------------------------------------VLILNGL
KAAVI----------------A--A---LVLLLVRHM---ITHPVS-RIH---AHTRKMAAGRLEEPLVLAARYPSSRDDEIHELA------EAVEIALL
QVRAHAEALGVFAHTFEGIMITDATATILSVNPAFTAITGYAASEAIGQTPRLLHSEHQQAS--------------WRGELWNRRKDGEAYLQWTSITTI
RDAAGQPHRYIAVMTDITEIRRKDEHIFHQAYHDALTDLPNRALLQNRLDHAIKTAQRDMTRIAVLFIDLDRFKVINDSLGHVTGDELLQCAARRLTNSV
RASDTVSRQGGDEFVILASIEH-ADAVHIAEKVIADMNEPFDIGEHRLNVGASVGISIYPQEGDDAATLLRNADVAMYAAKEAGRGTFRFFDPAMNERAQ
KRLHLEETLRRALSGNEFELFYQPKICLIDSRYCGMEALIRWRDPELGIVSPADFIPLAEETGLIEPIGNWVLETACAQMRRWADAGRIAGPVAVNVSAK
QLNNPDFAAELEAILKRHRLEASCLQLEVTESTVMTDPEMAIEALSKLAALGVTIAIDDFGTGYSSFSYLKRLPIHLLKVDRSFVTDIGISREDDEIVTA
IIQVALALKLMVVAEGVETARQAAFLNGLGCHFAQGYLYARPLPVKEFEDLLGA------
>tr|E1QEC6|E1QEC6_DESB2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfarculus baarsii (strain ATCC 33931 / DSM 2075 / VKM B-180
------------------------------------------------------------------------------------------------CPGP
E--DI----------------E--R---FLAQRRAAL---GLEPAV-DLG------GCLAAALGPEP--WAVQWADSQGRRLLLVA------VTKIVDQT
GQQAHRERAQVLECASEGIMVTDRDGHIIMVNRGFSELTGFDAVEVIGRTPEFLYPHDDHHG--------------WRGEVASLRKNGQAYPQLLHLQAI
KGPGGQVRNYVGDMHDITSIKRTEEQIAHQVYHDPLTGLPNRLLFQDRLEMALAHAKRQRDGVAVLFMDLDNFKHVNDSLGHAAGDKLLVAVARRLLAKV
RREDTMARLGGDDFLFLLPETAGDEAGQVAQQMLDELARPFRLGGKKLHIRASVGIALFPNDGQTPEKLIANAELAMYRAKEGCREGYCFFEPALNQKVR
HRLELENRLRTALQKEEFLVCYQPKIDLASLRTVGVEALVRWRRPGVGLISPGEFIPVAEETGLIIPLGRWVLRQACQQAQRWREQGRQ-LSVAVNLSPR
QLLDPDLTRAVAEALEESGLPPEQLELEITENAVMPSLELALGRLAELAALGARLAMDDFGRGYSSLYHLHRLPIDILKVDQYFIKEMTPHSRVSSIVEA
MVAMGRSMGLVVVAEGVENKRHLEMLAGMGCHQLQGFLFSRPLEPPRLEDYLAREE----
>tr|W0SEZ6|W0SEZ6_9RHOO Sensory box/GGDEF family protein OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_01745 PE=4 SV=1
---------------------------------------------------------------------------------------------IVSSNAL
KTFFV----------------A--V---FMMILFRRV---VTRRLG-KLG---QKVTDLVPGALPVPLVHSAQAMPRNLDELDAVA------WTL-----
--------VVILQNALVGIL-MVRNGVIVSCNRRLEEIFGYPAGGMNGLRTRVLYPTEEVYA-------------SVSDTLTQLKLDG--TPIWIEMSGR
LDPLRPRDASIWICSDVTERKAAEDQVKFIAFHDALTGLPNRLLVQDRLQQSMAGADRSKAKIALLVLDLDNFKTINDTLGHSIGDGVLREVARRLGECV
RDTDTVCRQGGDEFVILLPSLPDEATAPILVKLMERLIDPCRVEGHELTTSVSIGVAVYPDDGQDLETLMKKADLAMYRAKDAGRNTYRFFDQQMNIDAI
EQLSMRNGLRRALERGEFVLHYQPQIDLAGNTVIGVEALIRWNHPDLGMIPPARFIPVAEDSGLIIPISEWVLREACRQAAAWVKSGLPPILVAVNLSAV
QFKRSDVEQSVISALEESGIDPSLLELELTESILITDTETVLDMVKRLKQLGVKLSIDDFGTGYSSLSYLKRFQVNKLKIDQSFVRDLATDQEDAAIVGA
IIQMAHSLGLIVIAEGVETELILGQLRSFGCDEAQGYYFARPMPAEEVAAFRLRMN----
>tr|G2FBH7|G2FBH7_9GAMM Putative signaling protein OS=endosymbiont of Tevnia jerichonana (vent Tica) GN=TevJSym_ab00100 PE=4 SV=1
---------------------------------------------------------------------------------------------NLNS-IW
MLLLL----------------LG-A---ASILLIAYR---LSRPIG-RLE---KLAQRIGSRDYSAVSHIDRNDE------IGSLA------RTL----T
ISKEYMDEI----HSMRDLLLTDLAGRITRINRAFSQLSGYTSQQAIGQSIG------------Q-----IIPYSVSAHECTLQASDGKQVPILLSASML
PN--TGHQGMVLVAQDLTEYRVAQQQIHHLAYYDLVTGLPNRALFIDRLRQAIRSARREQNRMALFFLDLDRFKNINDTLGHEIGDQMLEAVAARLQSHK
REEDTIARFGGDEFTLIIPRIEQDDLITQAERITSLFQQPFNIGGLELFSGTSIGISLYPDDASDAETLIRNADTAMYRSKERRSNGFEFYTDDMNTLAT
EFMNIEHGLRRALENQAFELRYQPQVDIKTGRLKSVEALLRWRRSEHEILKPDLFLHVLEETGLVIPVGEWVLRQACRQLKAWQQLGVRIERVAVNISPR
QFVSPNLAETIAAILKEYQLPASSLELEITESGLMEDMEHTIELLGQLADMGVKLAIDDFGTGYSSLEHLRNFPVQTLKVDRSFIHGMETEQNRAAIVQA
IISLANILDLKVVAEGVETKQQQALLEEFGCRIVQGYLYSLPLMAEEIPGVTQHD-----
>tr|A3IYN4|A3IYN4_9CHRO Uncharacterized protein OS=Cyanothece sp. CCY0110 GN=CY0110_06459 PE=4 SV=1
---------------------------------------------------------------------------------------------ICRFDSD
RILTFINDAYCHYFNRTKEELENSS---FLETIFNEDQEKVCQVLD-SINPHLIVTHEYRVMNHQEDIRWHQWINRGIFDENGQLTEIQAVGRDIQEKIK
IETELKQSKKAIINAPLPIMIHAEDGEILQINDIFTELTGYTHDEIPTIDTWLEKAYGKRQNIIR-----PVINHIDEGEFVIDTSDEKQKIL--NFNSA
EQLSDGRRVVISMAIDVTERKKAEEKLRHNALHDTLTKLPNRLLFIDRLNQSIERIKRHTYSFAVLFIDLDRFKLINDSLGHIIGDRVLIQIATKLTSCV
RSLDTVARIGGDEFIILLNDLESIKAIHIAERILETLKLPIIIEQRNIVISASIGIAFNSQNNEEADDIIRNADLAMYKAKEQGKARYMIFDSVMYAQAQ
KRLELETNLRIGLEKQEFIVYYQPIISLVDKKLVGFEALVRWQHPQKGLIPPNEFIPVSEDTKLIIPIGEWVLLESCRQLATWQQKYPEMLKMSINLSIK
QLKNNTFVSKIEKILDQTGLNGNSLKLEITESILMENILELRDILRQIKSLGIELSIDDFGTGYSSLSYLHNLPVDNLKIDRSFVIEMNQSEGNYRIIET
IITLAHQLGLSVIAEGIETEQDLQTLRDLQCEFGQGYLFSKPLPSQAIESTNFRYE----
>tr|M7CMW8|M7CMW8_9ALTE PAS/PAC and GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Marinobacter santoriniensis NKSG1 GN=MSNKSG1_14432 P
----------------------------------------------------ATGLILTLHDITQ-RHNY--QMALEDLHQRNGLRLNAKLDGLFSVNDA
GLISYVNPQAIRILGYRAEDWIGRN---CHELLKPANSKGVAYSMALCPLLEALRTSNDQFRMADGALLPVGYKCIPLRLN-HHQNGILVVFRRRDQLAE
SDHPGGTNEAVLDQTSEAVIITGADTRILSVNRSFCEITGYRSEEALGQKPSFLKSGIHTPSFYQALWERVLSDGDWEGEIWNRRKTGEIFPFRGRISAV
RDHDQTIRNYVGVFSDASKARQAEESLQIARNYDTLTGLPNRQLCLEKIARGI--SDARGRGLAVILLDIDRFKLLNDSQGHDIGDDFLRTLANRLSESR
PDDASLFRWGSDEFLMLVEDIKDNAIPGILRSVFADLSRPFPLSNHQLIPSACAGISFYPDDAMDIRGLIQAADTALMRAKECGPSTVEFFKPALADRVH
RKFEIASELRRAVEQNELQLYFQPQVNSHSGQLIGVEALVRWRHPNKGLVPPNEFIPLAEELGLIELVGDWVLNRALEQMAQWRADKVPIPRVAVNIAPQ
QLG-PDLIRRVAALLEMYRLPADVLEIEITEGAL-ERGDDIVDLLNRLRAMGVQLSIDDFGTGYSSLAHLKHLPVNCFKLDKAFVDGLPDGVFDVAILKA
IITLGHSLNISVLAEGVETDAQFRFLEEQGIDSIQGYFFGRPMNPESFIEWLE-------
>tr|D9SIA8|D9SIA8_GALCS Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Gallionella capsiferriformans (strain ES-2) GN=Galf_012
----------------------------------------------------AIEIVANGRDVTQ-RHTY--QLAIEDLHRRNAKILEAAGDGLVSISPD
GKIVYTNERVRQILGWGGSELAGKS---CCQLFHARDADTSHDYPCDCPLIAQNLSATGYFSHKEGRAIRVDYSCTQMTDH-GKLSGAVLVFRESTEQSM
TFDQKQTSDVIFNAASEAVMVTDANRRITSVNRAFIKITGYAAEEMIGQTPKLLSSGVHTQNFYDAMYASLEASGYWAGEIWNRRKNGEIYPQWGSITAI
FGELGDLRSYIAVFSDVSKAKQAEEHLYHLANHDSLTGLANRSKFVDYLNHTLDARRNRGHKVAVAFIDMDRFKIINDTLGHTIGDQFLKAIATRISSQC
RNEDLLSRWGGDEFVLVMDRVDGDSVAEAVRRMMEVVRKPLLIDGHELEPTLSVGISFFPDDAQNTTDLVKAADTAMYRVKENGRNGYAFFTELQADESK
KKFEIVSELNRALRLNEFVLNYQPQVKPDTGEIVGLEALIRWEHPERGYLSPANFIPLAEELGMINQVGEWVIKAVCQQMSAWKLGGVTYPRVAVNVAPS
QLD-SGLADYVQRTLALYGLTADCLEIELTEGAL-ERGGEVAPVLKQLRELGITLSIDDFGTGYSSLGHLKNFPINCFKIDKSFVDGLPDSVQDAAIVKT
ILTLGENLNVEVVVEGVETLAQRDFLTSIGAKIIQGYCYGKPLSVEKITERLK-------
>tr|U5N7F9|U5N7F9_9BURK Bacteriophytochrome OS=Candidatus Symbiobacter mobilis CR GN=Cenrod_1152 PE=4 SV=1
----------------------------------------------------APAHQMAMRDVTE-RR------IIEDQLRISAHALKSISQGVLIGSVD
GKIVSVNDAFARITGYGRNEVVGQD---VHLLIGPLTDPNVVTEMDRALAQGGMF-AEMLNHCKDGRPFWNESTMSPVRNAAGTLTHFVGIVRDVTLRKV
SEQKIKLAASVFTHAREGIFIAEPDGTIIDINETFTSITGYERDDILGKKPNVLKSGRHESAFYAQMWNELLACGHWQGEIWNKKKNGVIYPEILSISAV
AGVDGSLQHYVGLFTDISLIKSHESQLEKLAHFDSLTGLPNRVLLSDRLREAMNAQ-RSSTGLAVVNVDLDGFKAINDRYGHEVGDQLLVVVADRIARIL
REGDTLARFGGDEFVAVFDDVPGAECVPLLDSLLDAASAPIDVAGYRLQVTASLGVSLFPQSQVDADMLVRQADQALYKAKQAGKNLYHIFDADQDRSVR
DHHECVNRLVYALRNGEFVLYYQPKVNMRTGQVLGVEALIRWQHPHRGLLAPGLFLPEIENHPLAVQLGEWVIDTALAQAQEWLKSGLDLH-VSVNVGAI
QLQQVGFVDRLRELLAAPEVGPHHLEIEVLTSAL-EDTRVVTQVIEQCHQLGVRFALDDFGTGYSSLTYLKRLPVSVLKIDQSFVRGMLDDSDDLSILDG
VLGLALAFRRAVIAEGVETVAHGAMLLQLGCDMGQGYGIARPMPAAAVPDWVQ-------
>tr|Q12T53|Q12T53_SHEDO Periplasmic sensor diguanylate cyclase/phosphodiesterase OS=Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)
-------------------------------------------------------RALNSLREKLEIIVSERTVQLKNSENRYRGLVESLQDEFYQHDIQ
GEIQYVSPSITHILGHKALNFRGSY-NKY-LTSNK-NNLAIPEL--------------------------------------------------------
-----------ILRCIKGEHV----------PP------------------------------F---------------E-IEIDIKGAYHTFEVLERPM
YNEQNECIGCEGIAHDITERKQHQRKLYRLSHFDKLTNLANRYLFTLSLGQAITSAKALNQTFALLFLDLTRFKIINDNLGHSAGDKLLQQAALRLTEQL
NSQDILARFGGDKFCILLPE-SDKQAEAVALTLIKILAQPFEVYEQSFILGCRIGISLFPTNGHDPETLLKQADAALYVA-KKRPAGFAFCSEEQAVYNQ
RRLKLEQGLRLADESFELSAVYQSLNQLPDAGLAGFEALIRWVHPELGPISPMEFIPIAEETGLIFELSRWMLTKVCRQLKEWHQLGFDFKRVSVNLSAL
DLININLAEEIINLIEEAGAEPRWLKIEITETALMAAPEQSISTLQQLVGNGIHVAIDDFGTGYSSLAYLKSLPATSLKIDQSFIRNIMTSIEDQAVVKA
VISMAHSLGKKVTAEGVETQEQLDFLITRHCDLAQGYLFAKPLIAQDCVKKYAANN----
>tr|G4SVL3|G4SVL3_META2 Diguanylate cyclase with PAS/PAC sensor (Modular protein) OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VK
-------------------------------------------------------QQLVNLQNELENLVEQRTAELKASEQKYRSLVENLRHEFYRQDPS
GLLTYVSPSVSNILGYSTEEFIANH-RDF-LTDNP-ANLNIDKN--------------------------------------------------------
-----------TDLCLKGMPQ----------PP------------------------------Y---------------E-VEVDSNGYIHWLEVMDSPV
FDQNGQCIGVDGIAHDITERKETHELLTSLSYYDDLTGLANRRLFADRLQQAINLAHRNKTSITLFYLDLDKFKSINDTLGHAAGDEVLKETAQKILSVI
RDSDIAARMGGDEFVILLPD-SDQAALSVANKLIKVLQQPYYIGEQMLSIGSSIGISVYPDNGTDGDSLINHADTAMYHA-KKEKLGYAFYSEDMQPAFI
SSEQLTECLRISNGH--FLIYYQSRHALISSDIIGFESLVRWYHPEQGILSPSEFLPLAEKSGLIDKITDWVVRQVCSQALAWEKMNLRPAKISINLSVN
QIQQQSLVERMLRDIDNLGVTPNWLEIEIKESTIMQNIDHAVNIIDQLNAAGLSVAIDDINSDSPILEQLDSLPAQTIKIDRALIRTLPINNENANSVIS
IIKKAHAHGKVVTAEGVESENQLDFLKTNRCDNVQGFYFSKPLAAADAENFLKSLS----
>tr|Q081Z5|Q081Z5_SHEFN Periplasmic sensor diguanylate cyclase/phosphodiesterase OS=Shewanella frigidimarina (strain NCIMB 400) GN=Sfri_2074 PE=4 SV=1
-------------------------------------------------------MALNELKNNLEKNVLERTLQLTISENRYRGLVESLEDEFYQHDTD
GFVQYVSPSVTHILGLTITGFGEYY-YKL-LTDNP-KNQLISGY--------------------------------------------------------
-----------IQRIINGEKL----------AP------------------------------F---------------E-IEIDTNGVIHTFEVLERPM
YDDEGECIGCEGIAHDVTSRKQQQDMLYQLSHYDDLTGLINRYFFKILLDENIQICLQNQQPLALLFLDLTRFKIINDNFGHSAGDYILQQAATRISTTL
NGTFTVSRFGGDKFCIALPN-KADEANAIATELVEVFQQHFEFLEQTIILGCRVGISLFPEDGKDAEAILNQADSALYEA-KKRPFGVAFCNKQQAIHNK
RRLIIEQGLRKAIEHYQLFAVYQPLILLPSQGLGGFEALMRWDHPDFGLISPAEFIPIAENTGLIFELSRWMLKTVCQQLVKWHEQGFDFKRVSVNLSAL
ELMSINLADDLLAVITDIGAEPKWLKFEITETALMAIPEQSIDILQKLIQADIHVAIDDFGTGYSSLAYLKSLPATMLKIDQSFICNLIHSAEDQAVVKA
VINMAHSLGKCVTAEGVELQDQLDFLIEHHCDVAQGYYFSKPMNADDAYHKYAVII----
>tr|S6JP75|S6JP75_9PSED Diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. CF149 GN=CF149_03694 PE=4 SV=1
-------------------------------------------------------ETPYRF-VRINRRLSSEISRLRSSEHHYRGMIESLSAIAWEARLG
DTYTYVSPQAEALLGYPIAEWLSLG-FWD-RILHPDDLARARAY--------------------------------------------------------
-----------REKKSDGLLIEINEGRLSGYDN------------------------------A---------------SASNKRKNGEIYPNWLTISAV
RNSDNLITHFVAVFSDISSLKHAQARLDHQAHHDPLTNLPNRLLFENRLCEVLADQRRNGQRSAVLFLDLDRFKNINDSLGHPVGDLLLKGIATRLKEQL
RDVDTVARLGGDEFIILLPGLKQNDAQMIAHKLLACFNAPFLAGEHELFISASIGTSVFPDDGDDVATLVKNADLAMYHSK-KGRNRVERYSHDLGSQAS
ARVVLSH-----LERGQVSLLYLPKISLDDFSLVGAEALLHWVHPILGEIPHERLIHLAEENGMIIQIGDWMLERACQQLHSWHQVYTPFGAISVNLASA
QLHQPGLLEHIQHLLNTCMLKPGFLQLKITESFITCQAEEACEALHRLKQLGVKLSIDDFGTGNSSLSYLKRLPLDTLKIDSSFIKGLPDDVHDAAIVHA
IITLGHSLQLTIIADGVETEAQRAFLAQAGCEHIQGAIVSAPLSAEKFAATFLRIS----
>tr|Q9I5W1|Q9I5W1_PSEAE Uncharacterized protein OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) GN=PA0575 PE=4 SV=1
-------------------------------------------------------ETPYRY-LAMNRRLRREVSRLRDSEQHYRGLVESLNAIAWEMRLE
NRFTYVSPHAERLLGYPLGEWLQPG-FWQ-RTLHPMDAEYAIHY--------------------------------------------------------
-----------CMSLEDGTLIDVNEGRLTGYRR------------------------------D---------------EVWNRRKTGELYPEWLTISAV
HNPQGEITHFVGVFADISTLKYAQARLDYQAHHDPLTGLPNRLLFESRLNHALDEAREESRPGAVLFIDLDRFKHINDSLGHPIGDLLLKAIAERLRDQL
RDVDTVARLGGDEFIILLPGLHQSDAEHVARKLLNAFTAPFQADGHEFFVSASVGIALFPKDGDDAPTLVKNADAAMYRAK-RGRSRIEYYTRELTYLAT
ERMALET-----LERDELQLYYQPKLSLESGLLVGAEALVRWYHPLFGEISPERFIPLAEDCGLILPLGDWVLEHACQQMGEWQKLHAPFGPLSVNLAGA
QLGQPQLIERLEQLLEQSGLEPSRLQLEITESFIMNQTEEALAVLHGLKRLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDKSFIRGLPDDPHDAAITRA
IIALGRSMQLTVIAEGVETEGQQSFLTHEGCEQIQGFVLSPPLPAELFASKFLKPR----
>tr|A0A081YC42|A0A081YC42_9PSED Diguanylate cyclase OS=Pseudomonas sp. AAC GN=FG99_11940 PE=4 SV=1
-------------------------------------------------------ETPYRY-VAMNRRLRGEVARLRDSEQHFRGLVESMAAIAWEMRLE
NRFTYVSPHAQELLGYPQHEWLQPG-FWQ-RTLHPADAEQAVSF--------------------------------------------------------
-----------CFSIRDGLLLEANEGRITGYGR------------------------------E---------------SAWNRRKSGELYPEWLTISAV
RGNNGETSHFVGVFADISTLKYAQARLDYQAHHDPLTGLPNRLLFESRLTSALKESQEEQQLGAVLFLDLDRFKHINDSLGHPVGDQLLKSIARRLREQL
RDIDTVARQGGDEFIILLPGLHQADAEHVAKKLLNCFSHAFVADDKEFFVSASIGISLFPVDGKDVATLVKNADAAMYRAK-QGRNRVEFYTRELTFQAN
ERVALEH-----LETHQLQLYYQPKQALDTGALVGAEALIRWSHPKYGAIPPDRFIPLAEETGLILPLGTWVLEEACRQMSRWQQSHAAFGPLSVNLAGA
QLYQHDVVDQVRELLQRYNLHAPRLQLEITENFLMHQTDEALTTLHALKRLGVQLAIDDFGTGYSSLSYLKQLPLDILKIDQSFVHGLPDDPHDAAIARA
IIALGRSMNLTIIAEGVEREEQERFLAEEGCDQVQGYALSPPLPAEQFAARFLTPL----
>tr|M4WRN5|M4WRN5_PSEDE Uncharacterized protein OS=Pseudomonas denitrificans ATCC 13867 GN=H681_02410 PE=4 SV=1
-------------------------------------------------------ETPYRY-VTMNRRLRGEMQRLRDSEQHYRGLVESLAAIAWEMRLE
NRFTYVSPHAQRLLGYPIKDWLEPG-FWQ-RTLYPDDADHAVAY--------------------------------------------------------
-----------CMSISDGRLVEVNDGRITGYAR------------------------------D---------------DVWNRRKNHELYPEWLTISAV
RNTDGELSHYVGVFADISTLKYAQAKLDYQAHHDPLTGLPNRLLFENRLTTALKEAQEDHHQGAVLFLDLDRFKHINDSLGHPVGDLLLQSIAQRLRDQL
RDIDTVARQGGDEFIILLPGLHRVDAEHVAKKLLHCFETAFIAGEQEFFVSASIGICLYPVDGNDVATLVKNADAAMYRAK-QGRNRVEFYTRELTFQAT
ERMALEH-----LESDQLQLYYQPKLALGSGQLVGAEALIRWKHPQFGAISPDRFIPLAEENGLILPLGDWVLREACRQMSRWQDSHAAFGPLSVNLAGA
QLRQPHLVERIRDLLARYHLQASRLQLEITESFLMHQTEEALSILHSLKNLGVQLAIDDFGTGYSSLSYLKQLPLDTLKIDQSFVHGLPDDPHDAAIARA
IIALGRSMNLTVIAEGVEHQAQEHFLEAEGCDQIQGYALSPPLPADAFANRFLTPL----
>tr|A0A024HA35|A0A024HA35_PSESB Uncharacterized protein OS=Pseudomonas knackmussii B13 GN=PKB_0528 PE=4 SV=1
-------------------------------------------------------ETPYRY-VAMNRRLRGEVARLRDSEQHYRGLVESMTAIAWEMRLE
NRFTYVSPHAQALLGYPLSEWLKPG-FWQ-RTLHPDDAEQAMSY--------------------------------------------------------
-----------CLSIRDGMLLEANEGRITGYNR------------------------------D---------------EAWNRRKSGELYPEWLTISAV
RDGQGEISHYVGVFADISTLKYAQARLDYQAHHDPLTGLPNRLLFEARLTTALKEAQEEHQQGAVLFLDLDRFKHINDSLGHPVGDQLLKSIAQRLREQL
RDVDTVARLGGDEFIILLPGLHQRDAELVANKLLQCFGKPYQANNQEFFVSASIGISLYPGDGRDVATLVKNADAAMYRAK-QGRNRTEFYTRELTFQAT
ERVALEN-----LETLQLQLYYQPKQSLLDGSLVGAEALIRWHHPQLGSIPPDRFIPLAEETGLILPLGTWVLEEACRQMSRWQQSHAAFGPLSVNLAGA
QLHQVDLVEQVRELLQRFNLHAPRLQLEITENFLMHQTEEALITLHALKGLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFIHGLPEDAQDAAITRA
IIALGRSMGLTVIAEGVEREEQEQFLASEGCDHVQGYALSPPLPADQFAARFLTPL----
>tr|U3H7P6|U3H7P6_PSEAC Uncharacterized protein OS=Pseudomonas alcaligenes OT 69 GN=L682_23425 PE=4 SV=1
-------------------------------------------------------ETPYRY-LRINRRLSGEMSRLRTSEQHYRGLVESLNAIAWEMRLE
HRFTYVSPHAERLLGYPLADWLETG-FWQ-RTLHPEDAQHAEYV--------------------------------------------------------
-----------CNELVDGRLIEANEGRITGYVA------------------------------G---------------EAWNRRKNGEPYPEWLTISAV
RNRGEQITHFVGVFADISTLKHAQARLDYQAHHDPLTGLPNRILFESRLQAALLDATTDAQRGAVLFIDLDRFKHINDSLGHPVGDLLLKSIATRLKDQL
RDIDTVARLGGDEFIILLPGLHTADAEHIASKVLACFSAPFEADEHEFFTSASIGISLYPEHGSDVATVVKNADAAMYRAK-KGRNRIEFYTRDLTFQAN
ERMALEN-----LERGELSLYYQPKLCLQNRRLIGAEALIRWHHPLFGEISPERFIPLAEENGLILPLGDWVLAEACRQMREWQDRHAPFGPLSVNLAGA
QLRQPQLVERIDRLLQDTGVIPCHLQLEITEGFIMSQAEEALAVLHALKALGVQLAIDDFGTGYSSLSYLKRLPLDIIKIDKSFVRGLPDDLEDAAIARA
IIALGRSMQLTVIAEGVETHAQEAFLTAEGCEQIQGYVVSRPLPADVFARQFLDPC----
>tr|S6AQW9|S6AQW9_PSERE Putative sensory box protein OS=Pseudomonas resinovorans NBRC 106553 GN=PCA10_05240 PE=4 SV=1
-------------------------------------------------------ETPYRY-LRVNRRLSNEMASLRGSEQHYRGLVESLNAIAWEMRVE
YCYTYVSPHAERLLGYPLANWLEPG-FWS-RTLHPDDAAWANAY--------------------------------------------------------
-----------CETISDGLLLEANEGRITGYSQ------------------------------P---------------EIWNRRKNGEPYPEWLTISAV
RDRHQQVTHYVGVFADISPLKHAQARLDYQAHHDPLTGLPNRLLFESRLQLALADAANDNHHGAVLFIDLDRFKHINDSLGHPVGDLLLKGIANRLREQL
RDIDTVARLGGDEFIILLPGLHNGDAQAVASKLLACFEAPLPAGQHEFFTSASIGISLFPEHGLDVATLVKNADAAMYRAK-RGRNRIEFYTRDLTHQAT
ERMALET-----LERNELSLSYQPKLSLQHQTLVGAEALVRWYHPQFGEIPPERFIPLAEECGLILPLGGWVLEHACRQMRQWQDGHAPFGPLSINLAGA
QLRQPQLVERLQRLIQSLGLEPQRLQLEITESFIMNQAEEALSVLHNLKALGVQLAIDDFGTGYSSLSYLKRLPLDVLKIDKSFVRGLPDDPNDAAISRA
IIALGRSMQLTVIAEGVETKAQEHFLAAEGCEQIQGFIVSAALPADTFAGKFLSPL----
>tr|U1ZTI0|U1ZTI0_9PSED Diguanylate cyclase OS=Pseudomonas sp. EGD-AK9 GN=N878_08810 PE=4 SV=1
-------------------------------------------------------ETPYRY-LRINRRLHSEMQRLRSREQHFRDLVESLSAIAWEAEPD
LRFTYVSPHAEKLLGYPQGDWLQPG-FWQ-QHLHPDDHQRTLRQ--------------------------------------------------------
-----------CLELRDGLLVEANEGRITGYRL------------------------------D---------------EIWNRRKNGELYPEWLTISAV
RNAEDRVTHFVGVFADISSLKHAQARLDHQAHHDPLTGLPNRLLFENRLRSALEGSRADDQLGAVLFLDLDRFKQINDSLGHPVGDLLLKAIAERLKLQL
RDIDTVARLGGDEFIILLPGLHQQDAEQVAQKLLECFAAPFQIDNHEFFISASIGISLYPKDGADVATLVKNADAAMYQSK-KGRNRSERYTRSLTFQVN
ERMAMEQ-----LERDELCLHYQPKLCLRSQRLVGAEALVRWPHPVFGDIPPDRFIPVAEESGLILPLGDWVLQQACRQLQHWQEEHGSFGPLSVNLAGA
QLHQANLLARIDELLQQHGLAPQRLQLEITENFIMNQAEEALGILHQLKQLGVQLAIDDFGTGYSSLSYLKRLPLDVLKIDQSFVRGLPDDPHDLAITRA
IIALGHSMQLTVIAEGVETKAQELCLAAEGCLQIQGYVVSRPLPADAFARKFLSPG----
>tr|U3BCB8|U3BCB8_PSEAC Putative sensory box protein OS=Pseudomonas alcaligenes NBRC 14159 GN=PA6_037_00510 PE=4 SV=1
-------------------------------------------------------ETPYRY-LRVNRRLHQEVNELRDSELHYRGMVESLNAIAWQMRLD
YCFTYVSPHAEKLLGYPLEDWLQPG-FWQ-RTLHPEDAARAEHY--------------------------------------------------------
-----------CVSLHDGQILEANDGRITGYDS------------------------------Q---------------QVCNKRKNGELYPEWLTISAV
RDHSGQITHFVGVFADISSLKQAQDRLDYQAHHDPRTGLPNRMLFESRLDNALNDARTDHQRGAVLFLDLDRFKHINDSLGHPVGDQLLKSIALRLREQL
RDIDTVARLGGDEFIVLLPGLHQRDAERVATKLLTCFHAPFQVDGHEFFISASIGISLFPEDGSDVATLVKNADAAMYSSK-KGRNRIEFYTRNLTFQAT
ERMTLEL-----VERDELSLHYQPKLCLSTGKLVGAEALIRWRHPVFGEIPPDRFIPLAEENGMILQLGDWVLQEACRQMRTWQDQHAPFGPLSVNLSGS
QLRQAQLGERIAAILATFGLGADKLQLEITESFIMTQAEEALLILHELKELGLQLAIDDFGTGYSSLSYLKRLPLDILKIDKSFVRGLPSDPDDAAITRA
IIALGRSLQMTVIAEGVETKAQEIFLTSEGCEQIQGYVISRPLSAESFAANFLGPL----
>tr|L8MGN5|L8MGN5_PSEPS Sensory box/GGDEF family protein OS=Pseudomonas pseudoalcaligenes KF707 GN=ppKF707_5616 PE=4 SV=1
-------------------------------------------------------ETPYRY-IRVNRKLSNEMASLRSSEQHYRGLVESLNAIAWEMRVD
YRYTYVSPHAERLLGYPLAAWLELG-FWH-RALHPDDAEWATAF--------------------------------------------------------
-----------CKSMRDGLLLEANEGRITGFDQ------------------------------R---------------EIWNRRKNGDPYPEWLTINAV
RDRHQRITHYVGVFADISPLKHAQARLDYQAHHDPLTGLPNRLLFESRLQLALADATSDHHHGAVLFIDLDRFKHINDSLGHPVGDLLLKGIASRLKEHL
RDIDTVARLGGDEFIILLPGLHNGDAQAVANKLLACFEAPFPAGQHEFFMSASIGISLFPEHGQDVATLVKNADAAMYRAK-RGRNRIDLYTQDLTSQAT
ERMSLET-----LERNELSLSYQPKLSLQHRTLVGAEALVRWYHPRLGEIPPERFIPIAEESGLILPLGDWVLTQACRQMQRWQNDHAPFGPLSINLAGA
QLRQPQLVERLQRLIQGLGLEPQRLQLEITEGFIMSQAEEALGVLHNLKALGVQLAIDDFGTGYSSLSYLKRLPLDVLKIDKSFVHGLPDDPNDAAISRA
IIALGRSMQLTVIAEGVETPAQEAFLTAEGCEQIQGFIVSAALPTEAFERKFLNPL----
>tr|A4XZL0|A4XZL0_PSEMY Periplasmic sensor diguanylate cyclase/phosphodiesterase OS=Pseudomonas mendocina (strain ymp) GN=Pmen_4029 PE=4 SV=1
-------------------------------------------------------ETPYRY-LRINRRLNSEMRNLRSREQHFRDMVESLSAITWEAESG
LTYTYVSPHAEKLLGYPLEDWLQPG-FWQ-RHLHPDDQQRALRR--------------------------------------------------------
-----------CLEMRDGLLIEANDGRITGYQL------------------------------D---------------EVWNRRKNGELYPEWLTISAV
RNADNQITHFVGVFADISSLKHAQARLDHQAHHDPLTGLPNRLLFENRLRSALDGSRAEDRAGAVLFLDLDRFKQINDSLGHPVGDQLLRAIAARLKLQL
RDIDTVARLGGDEFIILLPGLQQEDADQVAQKLLDCFTAPFDIDHHEFFVSASIGISLYPKDGADVATLVKNADAAMYQSK-KGRNRSEFYTRSLTFQVN
ERMAMEQ-----LERDELCLYYQPKFCLRSQRLVGAEALVRWPHPVFGDIPPDRFIPVAEESGLILPLGDWVLQEACRQLQCWQENNQGFGTLSVNLAGA
QLHQPSLVSRIGELLQQHGLAAGLLQLEITENFIMNQAGDALDILHRLKELGVQLAIDDFGTGYSSLSYLKRLPLDVLKIDQSFVRGLPDDPHDLAITRA
IIALGQSMQLTVIAEGVETKAQELCLAAEGCLQIQGYVISRPLSAEAFTRKFLPPG----
>tr|A0A0D6STE1|A0A0D6STE1_9PSED Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudomonas sp. FeS53a GN=SZ55_2264 PE=4 
-------------------------------------------------------ETPYRY-LRINRRLRGEMNRLRNSEQHYRGLVESLNAIAWEMNLD
YCFTYVSPHAERLLGYPLDEWKQPG-FWQ-RTLHPEDAERAFCY--------------------------------------------------------
-----------CQQLADGCLIEANEGRITGYEL------------------------------G---------------EAWNRRKDGETFPEWLTINAV
RNPEGQITHFVGVFADISPLKQAQARLDYQAHHDPLTGLPNRVLFESRLRQALAACEREGHEGAVLFLDLDRFKHINDSLGHPIGDVLLKSIATRLGNQL
GRNDTVARLGGDEFIILLPHLRHEEAQQLAERLLACFNAPFETQDHEFFISASIGISRFPEHGSDTATLVKNADAAMYQAK-KGRNRVELYTRDLTFQAT
ERMALEN-----LERHELCLYYQPKLCLRSGRLIGAEALLRWQHPLFGDISPERFIPLAEENGFILTLGDWVISEACRQMREWQDQHAPFGPLSVNLAGA
QLRQPGIVQRIDQQLRSAGVPAERLQLEITETFIMSQAEEALAVLHALKDLGLQLAIDDFGTGYSSLSYLKRLPLDIIKIDKSFVRGLPHEQEDAAIARA
IIALGHSMQLTVIAEGVETPAQEAFLRAEGCEQIQGYIVSRPVPADVFARQFLSPS----
>tr|F4DM98|F4DM98_PSEMN Diguanylate cyclase/phosphodiesterase OS=Pseudomonas mendocina (strain NK-01) GN=MDS_4367 PE=4 SV=1
-------------------------------------------------------ETPYRY-LSINRRLKREMRNLRSREQHFRDMVESLCAITWETESG
LTYTYVSPHAEKLLGYPLHEWLEPG-FWQ-RHLHPDDHQRTLRD--------------------------------------------------------
-----------CLELRDGRLIEANEGHITGHSF------------------------------D---------------QNWNRRKNGELYPEWLTISAV
RNRDNQITHFVGVFADISSLKHAQARLDHQAHHDPLTGLPNRLLFENRLRGALDGTRADDQLGAVLFLDLDRFKQINDSLGHPVGDQLLKAIAERLRLQL
RDIDTVARLGGDEFIILLPGLHQQDAEQIAQKLLECFGASFQLDNHEFFISASIGISLYPTDGQDVATLVKNADAAMYQSK-KGRNRCEFYTRSLTFQVN
ERMAMEQ-----LERNELCLYYQPKFCLRSQSLVGAEALVRWPHPLFGDIPPDRFIPVAEESGLILPLGDWVLEQACRQLQEWQESGRGFGALSVNLAGA
QLHQPSLLPRIGALLQRYNLAPELLQLEITENFIMNQAEEALDILHRLKQLGVQLAIDDFGTGYSSLSYLKRLPLDVLKIDQSFVRGLPDDPHDLAITRA
IIALGNSMQLTVIAEGVETKAQELCLAAEGCLQIQGYVVSRPLSADAFARKFLPPG----
>tr|U7A0V4|U7A0V4_9PSED Diguanylate cyclase OS=Pseudomonas sp. CMAA1215 GN=P308_30020 PE=4 SV=1
-------------------------------------------------------ETPYRY-IRINRRLSSEISRLRSSEYHYRSLVESLSAIAWEARVD
FTYSYVSPHAEPLLGYPLAHWLVPG-FWR-NIIHPADLTRAQAF--------------------------------------------------------
-----------CDHQRDGLLLEVNEGRITGFNS------------------------------A---------------MSSNRRKNGELYPNWLTINAV
RNQEHQTTHFVAVFADISSLKHAQARLDYQAHHDPLTGLPNRTLFESRLLAALNSQQDSGGQGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAVRLKEQL
RDIDTVARLGGDEFIILLPGLHQSDADHIASKLLNCFNAPFQAGEHEFFISASIGTSLYPKDGCDVATLIKNADAAMYRSK-KGRNRVERYTRELTAQAS
ERVALEH-----IERNELTLYFQPKISLGNHELVGAEALIRWRNPSFGEVPPEHFIPLAEENGLILPIGDWVLEQACLHLQHWNQHYESFGPLSVNLAGA
QLRQPDLLNRIEQLLRDHDLQPGLLQLEITENFIMSQAEEALEVLHQLKHLGVQLAIDDFGTGYSSLSYLKRLPLDFLKIDQSFVRGLPDDPHDVAIVRA
IIALGRSMQFTVIAEGVENQEQQAFLALEGCEQIQGYIVSLPLEAEEFCARFLQIR----
>tr|S6JCV5|S6JCV5_9PSED Putative sensory box-containing diguanylate cyclase OS=Pseudomonas sp. CF161 GN=CF161_04753 PE=4 SV=1
-------------------------------------------------------ETPYRY-IRINRRLSSEISRLRSSEYHYRGLVESLSAIAWEARID
YTYSYVSPHAEALLGYPLSHWLIPG-FWR-NIIHPADLTRAQTF--------------------------------------------------------
-----------CDHQRDGLLIEVNEGRITGFNS------------------------------A---------------MSSNRRKNGELYPSWLTISAV
RNKEQSITHFVAVFADISSLKHAQARLDYQAHHDPLTGLPNRTLFESRLLTALNGQQENGSQGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAVRLKEQL
RDIDTVARLGGDEFIILLPGLQQSDADHIAGKLLNCFSAPFQAGEHEFFISASIGTSLYPKDGTDVATLIKNADAAMYRSK-KGRNRVERYTRDLTAQAS
ERVALEQ-----IERNELSLYYQPKISLIDQELVGAEALLRWRHPTFGDVPPEHFIPLAEENGMILQIGDWVLEQACQQMSAWNERYAPFGPLSVNLAGA
QLRQPNLLGRIEQLLKDNHLRPGFLQLEITENFIMSQTEEALEVLHQLKRLGVQLAIDDFGTGYSSLSYLKRLPLDFLKIDQSFVRGLPDDPHDVAIVRA
IIALGRSMQFTVIAEGVESHEQQAFLGAEGCEQIQGYIVSLPLCADEFAATFLQMG----
>tr|A0A099DXG7|A0A099DXG7_9PSED Diguanylate cyclase OS=Pseudomonas sp. H2 GN=MD26_23470 PE=4 SV=1
-------------------------------------------------------ETPYRY-IRINRRLSSEISRLRSSEYHYRGLVESLSAIAWEADAD
FTYSYVSPHAEDLLGYPLHDWLKPG-FWR-SILHPEDALWAQAY--------------------------------------------------------
-----------CDSQSDGLLIEVNEGRLTGYDL------------------------------N---------------PSYNKRKNGEFYPGWLTISAV
RNSEHEITHFVAVFADISSLKHAQAKLDYQAHHDPLTGLPNRALFENRLQAVLTCAQVSNRQGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAQRLKEQV
RDVDTVARLGGDEFIILLPGLHRSDANSIAGKLLACFSAPFQAGEHEFFTSASIGISLYPQDGSDVSTLIRNADAAMYRSK-KGRNRVEAYTRDLTAQAS
ERIALEH-----VERNEMSLCFQPKLSLKTQSLVGAEALIRWSHPTFGEVPPEHFIHLAEENGTILQLGDWVLEQACRQMHLWKMHYEDFGPLSINLAGA
QLRHPHLARRIEQLLKTYQLKAGDLQLEITENFIMSQAEEALAVLHQLKKLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDKSFIRGLPEDPHDAAIARA
IIALGRSMQFTIIAEGVENQAQQRFLAAEGCEQIQGYIVSLPLPAEEFAAAFLRIA----
>tr|A0A0A1I1H9|A0A0A1I1H9_9PSED Sensory box/GGDEF family protein OS=Pseudomonas sp. SHC52 GN=BN844_5523 PE=4 SV=1
-------------------------------------------------------ETPYRY-IRINRRLSSEIARLRSSEYHYRGLVESLSAIAWEAKVD
FTYTYVSPHAEDLLGYPLAHWLIPG-FWR-NIIHPADLIRAQTY--------------------------------------------------------
-----------CDHQSDGLLIEVNEGRITGFNS------------------------------A---------------LSSNRRKNGELYPSWLTISAV
RNRDQQITHFVAVFADISSLKHAQAKLDYQAHHDPLTGLPNRTLFESRLLTALNNQQENGGQGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAVRLREQL
RDIDTVARLGGDEFIILLPGLQQSDAEHIALKLLNCFAAPFQAGEHEFFISASIGTSLYPQDGCDVATLVKNADAAMYRSK-KGRNRVESYTRDLTAQAS
ERVAMEY-----IERNELSLSFQPKISLADNRLVGAEALIRWTHPTFGDVPPEHFIPLAEENGMILQIGDWVLEHACRQLYEWNSAYESLGPLSVNLAGA
QLRQPNLLIRIEQLLRENHLKPGLLQLEITENFIMSQAEEALTVLHQLKKLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFVRGLPDDPHDAAIVRA
IIALGRSMQFTIIAEGVETLAQQQFLAEEGCEQIQGYIVSLPLGADEFAATFLRMT----
>tr|A0A075PEJ1|A0A075PEJ1_PSEFL Diguanylate cyclase OS=Pseudomonas fluorescens GN=HZ99_14820 PE=4 SV=1
-------------------------------------------------------ETPYRY-IRINRRLSSEISRLRSSEYHYRGLVESLSAIAWEADID
FTYSYVSPHAEELLGYPRAHWLIPG-FWR-NIIHPADLTRADSF--------------------------------------------------------
-----------CQRQCDGLLLEVNEGRITGFNS------------------------------A---------------MSSNRRKSGELYPSWLTISAV
RNLEQSITHFVAVFADISSLKHAQARLDYQAHHDPLTGLPNRTLFENRLQTALNNQQEAGSQGAVLFLDLDRFKHINDSLGHPIGDLLLKDIAVRLKEQL
RDIDTVARLGGDEFIILLPGLQQSDAQHLANKLLTCFTLPFQAGEHEFFISASIGTSLYPQDGTDVATLVKNADAAMYRSK-KGRNRVERYTQDLTAQAN
ERVALEH-----IERDELFLYYQPKLSLDTQQLIGAEALIRWRHPTFGDVPPEHFIALAEENGMILQIGDWVLEQACCQLHQWRKSYDDFGPLSVNLAGA
QLRHPNLLGRIEQLLRDNRLEPDCLQLEITENFIMSQAEEALEVLHKLKRLGVQLAIDDFGTGYSSLSYLKRLPLDFLKIDQSFVRGLPDDPHDAAIVRA
IIALGHSMQFTIIAEGVETPAQQAFLADEGCEQMQGYIVSLPLPPDIFAATFLHMT----
>tr|L1LVG6|L1LVG6_PSEPU Sensory box protein OS=Pseudomonas putida CSV86 GN=CSV86_22366 PE=4 SV=1
-------------------------------------------------------ETPYRY-IRVNRRLSSEISRLRSSEYHYRGLVESLSAIAWEADAD
FTYNYVSPHAENLLGYPLSAWLTPG-FWR-SILHPDDALWAQAY--------------------------------------------------------
-----------CDAQSDGLLLEVNEGRLTGFDM------------------------------Q---------------TSLNRRKNGELYPAWLTISAV
RNPELGTTHFVAVFADISSLKHAQAKLDYQAHHDPLTGLPNRTLFENRLQAALSCPQASSRQGAVLFLDLDRFKHINDSLGHPVGDLLLKAIAHRLKEQV
RDIDTVARLGGDEFIILLPGLHQSDAEHIAQKVLACFNAPFQAGDHEFFSSASIGISLYPQDGIDVASLIRNADAAMYRSK-KGRNRVEAYTRDLTAQAS
ERIALEH-----IERNELSLYFQPKLSLKTQRLIGAEALIRWANPNFGDVPPERFIPLAEENGMILQLGDWVLEHACRQMQAWKRQYQAFGPLSVNLAGA
QLRQPGLVRRIEQLLRTHQLKAGDLQLEITENFIMSQAEEGLAILHQLKRLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFIRGLPDDPNDAAIARA
IIALGRSLQLTVIAEGVETPAQQQFLAREGCEQIQGYIVSLPLPANAFAESFLRIV----
>tr|A0A0C2EJ39|A0A0C2EJ39_9PSED Sensory box/GGDEF family protein OS=Pseudomonas batumici GN=UCMB321_0426 PE=4 SV=1
-------------------------------------------------------ETPYRY-IRINRRLSSEIARLRSSEYHYRGLVESLSAIAWEARMD
FTYTYVSPHAEALLGYPLAHWLIPG-FWR-SITHPADLTRAQAF--------------------------------------------------------
-----------CDKQSDGLLLEVNDGRLTGYNS------------------------------A---------------TSCNRRKNGELYPSWLTISAV
RNRDTVVTHFVAVFADISSLKHAQARLDYQAHHDPLTGLPNRSLFESRLLAALHSQTENGGQGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAVRLKDQL
RDIDTVARLGGDEFIILLPGLHQSDALHLANKLLGCFSAPFQAGEHEFFISASIGTSLYPKDGNDVATLIKNADAAMYRSK-KGRNRVESYTRDLTAQAS
ERVALEH-----IERQELHLLYQPKISLDGGQLVGAEALIRWQHPTLGEVPPEHFIPLAEENGMILQIGDWVLERACRQMQRWNRTHRDFGPLSVNLAGA
QLRQPNLLARIEQLLKDYCLEPGCLQLEITENFIMSQAEEALEVLHQLKRLGVQLAIDDFGTGYSSLSYLKRLPLDVLKIDQSFVRGLPDDPHDVAIVRA
IIALGRSMQFMVIAEGVENQAQQAFLAAEGCEQIQGYIVSLPLPAEEFAATFLHMT----
>tr|A0A023C6R9|A0A023C6R9_9PSED Diguanylate cyclase OS=Pseudomonas extremaustralis 14-3 substr. 14-3b GN=PE143B_0121000 PE=4 SV=1
-------------------------------------------------------ETPYRY-IRINRRLSSEISRLRSSEYHYRGLVESLSAIAWEASVD
FTYSYVSPHAEELLGYPRAHWLIPG-FWR-NIIHPADLTRTEAY--------------------------------------------------------
-----------CYRQRDGLLIEVNDGRITGYPS------------------------------A---------------TSSNRRKNGEVYPSWLTISAV
RNRDHMITHFVAVFADISSLKLAQARLDYQAHHDPLTGLPNRTLFESRLQAALNGHQDTGKQGAVLFLDLDRFKHINDSLGHPVGDLLLKDIAVRLKEQL
RDIDTVARLGGDEFIILLPGLQHNDAQYLANKLLACFTPPFQAGEHEFFISASIGTSLYPQDGTDVATLVKNADAAMYRSK-KGRNRVESYTRDLTAQAN
ERVALEH-----IERDELSLYYQPKLSLATQELIGAEALIRWRHPAFGDVPPEHFIALAEENGMILQIGDWVLEQACRQMHAWQTTFEPFGPLSVNLAGA
QLRHPGLLGRIEQLLHDYQLDPGCLQLEITENFIMSQAEEALEVLHQLKHLGVQLAIDDFGTGYSSLSYLKRLPLDFLKIDQSFVRGLPDDPHDAAIVRA
IIALGHSMQFTIIAEGVESAAQQAFLAAEGCEQMQGYIVSLPLPPELFATTFLRMQ----
>tr|A0A0B0HAD4|A0A0B0HAD4_SOVGS PAS S-box/diguanylate cyclase domain-containing protein OS=Solemya velum gill symbiont GN=JV46_14180 PE=4 SV=1
-------------------------------------------------------ETPYSN-VTLRKKVQQRTSQRRKSEARFRNLVESTSDWIWEVGPD
ALYSYVSPKVEELLGYKPEELLGKS-PLD-LMPESEAERVAEKF--------------------------------------------------------
-----------GSIVTQGRPCAYPSGSYIGIPL------------------------------Y---------------SAWNRRKNGDVYPAWMTIDTI
RDEKGQLDQFVSVYSDISAIKESEERLQFLAHHDPLTKLPNRLLFSARLEHALQHAHRQNELVAVMFLDLDNFKQINDGLGHPVGDKVLQKVARRLSAIM
RDEDTVARMGGDEFALVFGDISDMGASQVASKVLSVFEAPLEIDHHRLYVTSTLGISLYPSDGENVATLLKNADTAMYHAK-EGKNQFCFYTDDLNSEAL
EKLNLEN-----LNNDEFEVYYQPQYELSSGRLTGAEALIRWNHKELGLVPPDEFIPMAESNGLIIPIGRWIMKQACSQVKTWQEAGFDIDRIGVNVAGQ
QIQNSDIVETVKDVLKETKLEPACLELEITESFIMQQAEKAISTLEELRKIGVALAIDDFGTGYSSLSYLKRLPIDRLKIDRSFIKDIPYDSDGVAITKA
IIALGKSMQLNVIAEGIETDEQHDFLTEKGCDEVQGYLYSRPLNAQEIEEIFQKEN----
>tr|I4NB71|I4NB71_9PSED Diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. M47T1 GN=PMM47T1_01695 PE=4 SV=1
-------------------------------------------------------ETPYRY-LRINRRLSSEISRLRSSEYHYRGLVESLSAIAWEARTD
FAYTYVSPHAEALLGYPLTHWLKPG-FWR-SILHPDDAARAQAY--------------------------------------------------------
-----------CGAQSDGMLLEVNDGRLSGHTS------------------------------R---------------VSHNRRKNGELYPCWLTISAV
RNADQALTHFVAVFADISSLKHAQARLDYQAHHDPLTGLPNRTLFESRLQASLNREHDDSGQGAVLFLDLDRFKHINDSLGHPVGDLLLKGIAQRLKEQV
RDIDTVARLGGDEFIILLPGLQQMDAEHIANKLLACFAAPFQAGEHEFFTSASIGTSLYPQDGSDVASLIKNADAAMYRSK-KGRNRVESYTRDLTAQAS
ERVALEH-----IERNELSLAYQPKFSLRDHALVGAEALIRWSHPVFGEVPPERFIQLAEENGMILQIGDWVLEQACRQMYQWQQRYQDFGPLSVNLAGG
QLRQPSLLKRIEQLLHEYNLAPGRLQLEITENFIMSQAEEALAVLHQLKQLGVQLAIDDFGTGYSSLSYLKRLPLDILKIDQSFVRGLPADTHDAAIVRA
IIALGRSMQLTVIAEGVENQAQQQFLAEEGCEQIQGFIFSVPLAPEEFAASFLRMK----
>tr|Q0A564|Q0A564_ALKEH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / M
----------------------------------------------------------------------------------------------------
-----------------------------------------------RVAAGRYFEGEETFRRRDGSEIPVEVSSRPLYQWAGSVT----LFRDITERRR
ARARLKLAASVFTSANEGILITDPQARILMVNQAFTRITGYHQDEVEGRDPKLLASGRHGPEFFQELWRVLDEHDHWQGELWNRRKSGELYLQLITISAV
RDESGRLINYVGLLSDITDMKAYQRKLEFLTHYDPLTELPNRVLLLDRLRKAMQLAQREQRRVCVAYVDLDDFKTINDVHGHRVGDQVLLELASRLSAAR
REGDTASRLSGDEFAMVFVNLGSAECHRMAARVLDAVARPITIEGVALQTSASIGVAHYPQDEVDAEQLLRQADQAMYQAKLQGKNRHHVFDVAGDRQLR
DQHESLTRLELALARGEFVLHYQPKVNLRTREVVGAEALIRWQHPERGLLPPAAFLDDLNGQPLEVAVSRWVMARALEQVETWSEQGVH-LPVSVNVPAL
HLQQADFVDQIRELLARPGLPRNSLELEILESSALASLDHVSRVIQGCAALGVDFSLDDFGTGYASLSYLKRIPVRIVKIDRSFVRDMLEDADDLALLEG
IVRLTQVFDLQLIAEGVETPEQGERLLELGCEQAQGYGIGRPMPAGSLLEWLSAW-----
>tr|G4E4E3|G4E4E3_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodospira sibirica ATCC 700588 GN=ThisiDRAFT_1172 PE=4 SV=
----------------------------------------------------------------------------------------------------
-----------------------------------------------TVSAGQEYTAQEQFRRADGSIFSVWVRSRPIIQNTGSVT----SFSDITTRKN
TEQRLRLAASVFTSAHEGIMITDTEGTIVEVNETFSRITGYLRKEVLGRNPRLLKSGQHAQVYYENLWHSLRNQGHWSGELWNRRKNGELYAQLANISAV
RNSQGQTEHYVTLFTDITPIKEHQKQLEHIAHFDALSGLPNRVLLADRLRTALLQAQRRGQMLALAYLDLDGFKAINDSYGHHTGDELLIVLSQRMQETL
RAGDTLARLGGDEFVVVLVDLDSSDAEPVLQRLLAAVAKPVPLHGRFFTVSASIGVTAFPQDDGDADQLLRHADQAMYVAKQMGKNRYHWFDLDQDADIR
IQQKTLSEIQQALESGAFVLHYQPKVNLKTGALIGAEALIRWQHPQHGLLSPASFLPLIEDCPLGARLDEWTIGQAMLQITAWQQQGLH-VPISVNIGAQ
LLQQGEFFSRLCALFEAPEVNPMHLELEILETSALEDMQHVANTLKRCRELGVGLALDDFGTGYSSLSYLKKLPTNVLKIDQSFVRDMLEDPDDLSIVKA
VLGLASAFGHTVVAEGVESSEHARVLRALGCEFAQGYGIAKPMPADQLPIWLDAW-----
>tr|A0A063XXJ8|A0A063XXJ8_9ENTR Diguanylate cyclase OS=Kosakonia radicincitans UMEnt01/12 GN=AW40_05575 PE=4 SV=1
------------------------------------------------------------------------------------------MMAAVLIDEQ
DRVMFYNRAAERLWGYSRDDVLGQS---VSILIPHDLKAAHPGFIRHHREGGEGMSRELQLERKDGKRIWTRFSLSRVV--NAGKVCYLALARDATLEVE
QREQTRLLLLAVDHISKPVIVLDTGRRIVQANRAFTEAFGLSVSQAAGKRLDNILNIPDAPDNRQRLQNLLRKNERDQNEFQALASTGENVWFSATLSPV
LAKNGQLQNLVMTFSDITEDRKSRQQIEHLIKFDPLTGLPNRSHLQEHLDQQLATAE--TKAPVVLMMTVDHFQDVIDAQGYSAAEQILSIVANRLHDSL
GAGQYLSKIEGQQFVLVDSENDVSSMTRVVETLENAVSEPISFNNTTLSLTLSIGISHEA--GKDRDWLLSTAHSAMDHIYRSGGNGWQFFNEELNRAAT
ERLLLGAALKRAVAENRLRLVFQPQINIATGQLYGFEALARWWDPEHGDVPPARFIPLAEEVGEIENIGVWVLREACRQLAQWRKTWPDFPALSVNLSAI
HFHNIQLPVQVLQAINEFAIPGEMLTLEITESMVMAPDDELSTRFQALRDMGVGLSVDDFGTGFSGLSRLVTLPVTEIKIDKSFVDGCLTDNRSRSLLEA
ITSIGQSFGMTVVAEGVETHEQLQLLRHIGCPVVQGYYFSRPMPPEEVPEWYSTTF----
>tr|M1JH23|M1JH23_CITAM cAMP phosphodiesterase OS=Citrobacter amalonaticus Y19 PE=4 SV=1
------------------------------------------------------------------------------------------MMGAVLINEN
DEVLFFNPAAEKLWGYRRDEVIGNG---ISMLIPHDLRPAHPDYIRHNREGGEGMSRELQLERKDGSKVWTRFALSKVNVG---KIFYLALVRDASVEME
---Q-KLLVLAVDHLDRPVIVLDPARRIVQCNRAFTEMFGYGITDAAGQQPDDLLNIPEESDNRQRLKQLLWKTTRDQDEFLMVTRAGEKIWIKASVSPV
HNPRSELQNLVMTFSDITEERQSRQHIEHLLQFDPLTGLPNRNHLHAYLDDLIVGAK--AFSPVVFLISVDHFQDVIDSLGYAVADQVLQQVINKIRERL
RPNQYLSRIEGTQFVLVSDDHEMSNITQFADELINIGSEATLFDDKPFPLTFSIGISYE-A-GRERDYLLSTAHNAMDFIRKAGGNGWQFFNPEMNLAVK
ERLQLGAALKNAIVSNQLRLVYQPQIFAQTGELYGFEALARWSDPVHGHVPPNRFIPLAEETGEIENIGRWVVREACRQLAEWRTMSLTIPTLSVNLSAL
HFRSNQLPDQVSEAMVEFAIPGDQLTVEITESMMMEQDEEILRRIEILRNMGVGLSIDDFGTGFSGLSRLVSLPVTELKIDKTFVDRCQTEKRIQSLLEA
IISIGQSLNLVVIAEGVETKEQFELLRSMNCPVIQGYYFSRPIPANEIATWMQTAL----
>tr|F0JR27|F0JR27_ESCFE cAMP phosphodiesterase OS=Escherichia fergusonii ECD227 GN=dos PE=4 SV=1
------------------------------------------------------------------------------------------MMGAVLINEN
DEVLFFNPAAEKLWGYTREEVIGNN---ISMLIPQDLRPAHPDYIRHNREGGEGMSRELQLEKKDGSKIWTRFALSKVTAG---KIFYLALVRDASVEVA
---Q-KLLIIAVDHLDRPVIVLDPERRIVQCNRAFTEMFGHCVSEAAGKQPDELLNIPELSDNRLRVKQLLWKYGRDQDEFLMLTRAGEKIWIKASISPV
YDKMSVLQNLVMTFSDITEERQSRQHIEQLIQFDPLTGLPNRNNLHSYLDELVG--K--DISPVVYLISIDNLQDVIDSLGYAWADQAVLEVVHRIRDKL
KPDQYLCRVEGIQFVLVSQENDVSTITQMADELKSISSPPVLIDDKVFPLTLSIGISYD-V-GKNRDYLLSTAHNAMDFIRKNGGNSWQFFNPAMNQMVK
ERLILGAALKEAIANNQLRLVYQPQIYSETGELYGFEALARWNDPQHGNVPPSRFIPLAEEIGEIENIGRWVVREACRQLAEWRSLALNIPTLSVNLSAL
HFRSSQLPNQVSEAMEEFAIPGGQLTVEITESMMMEQNEEILSRIQILRNMGVGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRCLSEKRIRSLLEA
ITSIGQRLNLEVVAEGVETKEQFELLQEIRCPVIQGYFFSRPLPAEDIPGWMTSAL----
>tr|A0A0D0NYC1|A0A0D0NYC1_CITRO Citrobacter rodentium strain ATCC 51459 Contig128, whole genome shotgun sequence OS=Citrobacter rodentium GN=TA05_10980 PE=4 SV
------------------------------------------------------------------------------------------MMGAVLINDN
DEVLFFNPAAEKLWGYNRDEVLGQS---ISKLIPHDLRAAHPDYIRHNREGGEGMSRELQLERKDGSKIWTRFALSKVTVG---KIFYLAFVRDASVEME
---Q-KLLVLAVDHLDRPVIVLDHERRIVQCNRAFTEMFGYGIQDAAGQQPDTLLTIPETADNRLRLKQLLWKTERDQDEFLALTRAGEAIWIKASISPV
YDPRTRLPNLVMTFSDITEERQSRQQIEHLMQFDPLTGLPNRNHLHAWLDESVAANP--QHPPVVFLIAVDHFQEAIDTLGYALADQVLLQAINKIRDRL
RPDQYLSRIESTQLVLVSHDSEMSNITQFADELIAIGNEAILFDDKPFQLTFSIGISYE-A-GKDRDYLLSTAHNAMDYIRKAGGNGWQFFNPQMNRAVK
ERLQLGAALKSAIASNQLRLVYQPQIFADTGELYGFEALARWHDPVHGHVPPNLFIPLAEETGEIENIGHWVVREACRQLAEWRAMSLNIPALSVNLSAL
HFRSNQLPDQVSGAMAEFAIPGEQLTVEITESMMMEQDKEIFTRIGILRNMGVGLSVDDFGTGFSGLSRLVSLPVTELKIDKTFVDRCQTEKRIQSLLEA
IISIGQRLNLVVIAEGVETKAQFEMLRAARCPVIQGYYFARPIAANEIPAWMNSSL----
>tr|S1IW65|S1IW65_ECOLX Oxygen sensor protein DosP OS=Escherichia coli KTE107 GN=A1WS_02067 PE=4 SV=1
------------------------------------------------------------------------------------------MMGAVLINEN
DEVMFFNPAAEKLWGYKREEVIGNN---IDMLIPRDLRPAHPEYIRHNREGGEGMSRELQLEKKDGSKIWTRFALSKVSAG---KVYYLALVRDASVEMA
---QQKQLIIAVDHLDRPVIVLDPERHIVQCNRAFTEMFGYCISEASGMQPDTLLNIPEFADNRIRLQQLLWKTARDQDEFLLLTRTGEKIWIKASISPV
YDVLAHLQNLVMTFSDITEERQSRQHIEQLIQFDPMTGLPNRNNLHNYLDDLVD--K--AVSPVVYLIGVDHIQDVIDSLGYAWADQALLEVVNRFREKL
KPDQYLCRIEGTQFVLVSLENDVSNITQIADELRNVVSKPIMIDDKPFPLTLSIGISYD-V-GKNRDYLLSTAHNAMDYIRKNGGNGWQFFSPAMNEMVK
ERLFLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNIHIPALSVNLSAL
HFRSNQLPNQVSDAMQAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRCLTEKRILALLEA
ITNIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSRPLPAEEIPGWMSSVL----
>tr|C6C676|C6C676_DICDC Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Dickeya dadantii (strain Ech703) GN=Dd703_3932 PE=4 SV=
------------------------------------------------------------------------------------------IVAVVLINDA
GCVLLFNRAAEILWGYERQEMRGRP---VVSLLAPVCRPAYLDAIRSNQADSAKTKCEWLLERKDGGQFWGRLPLSKVE--VNGRTYRMLMAWDVSLDVE
ARWQNRLTMLAIDNAERPVVLLDNACRVIRVNYSFSRLYGYALEDIVGNTLDGIMSYSLDQDSAGKKMSVMWGRSRVQAEVAIRCRDGREAFGRMASSPL
IDDDEFYGYSINVISDITEEQQNRQRMVQLVQYDPLTGLPNQYHLQRYLDDILSQQP--TREVTLFSVGLDRFKDINEAFGHAAGDRVLVAVTHRLQAFL
RAGEWLSRPEGDRFVIVAPDCSAHRASLMTEQLRETISQPVELDGHRLSLSASVGISHYLEGGSNRETLLDNAKVAMYRAKEAG-GGYQFFSADMNVAAS
ERLLLGGALKRAINNGELELYYQPQIRLDSGELYGMEALARWYDPVFGNVPTSKFIALAEDIGEIEALSYWALCEACRQLSLWDLAGARVPVVSVNFSPL
CFH-RDLPETITTILQSFSLTGERLTIEITESAAMALTPDMLAVVHRIRGNGIGVSIDDFGTGFSNLSNLVNLPVTEVKIDRSFIDKCESEERLQALVEA
VVGIGRSLKLEVVAEGVETEGQSALIGKLGGRIAQGYLFARPMKASDVPGWLQEYQ----
>tr|A9IE83|A9IE83_BORPD Bordetella petrii strain DSM 12804, complete genome OS=Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) GN=Bpet
------------------------------------------------------------------------------------------IVAAVLVDEN
DCVLFFNQAAEQLWGYERHEVLGKN---MQPLLPKSLRGAHGGYVRKNRVGGAGMSREVLMERKSGQQVWAMFSLSKID--LEGRIHYLALVRDVSDEVA
MREQNRMLLIAVNNTDRPVLVLDAQRRIAHVNRAFTELWGYEMDEVLGREPSSFLTSPNMVDEFRHFDSRPWGRERLQDDALVVSRDGKETWIRVSSSPI
AGHDGFQGYSVDVITDITEERQNQQRVNQLVRYDILTGLPNRGLLRQHIDELLSTDP--EQEIAFFYLGLDRFKDINDTLGHASGDLVLVETGNRLKSHL
DDGQFLARVEGDMFVLVVPDCDVHRAALVAAHLQRVAGAPIDISGFSLDPTVSIGISQYPESSRDREDLLRNAKSAMGQVKASGGGEFLFFSSGMNEVAR
DRLLLGTALRRAIAGGCLRLEYQPQVRPDSGELYGVEALARWRDPEFGVIPPGRFISLAEEIGEIEAIGRWALREACRQMAVWRDEGVQVPVVSVNLSPL
SFRGSDLPDFVAGLLQQYALPGECLTIEITESAAMALTAGMLEVIHGIRALGVGLSVDDFGTGFSSLSNLANLPVTEVKIDRSFIDKCLQESRLQSLVMA
VIGIGQNLHLTVVAEGVETEAQRELLKAHHCPVIQGYLFSRPLPPADIPNWIRTAA----
>tr|N6Z6L5|N6Z6L5_9RHOO cAMP phosphodiesterase OS=Thauera linaloolentis 47Lol = DSM 12138 GN=C666_10215 PE=4 SV=1
------------------------------------------------------------------------------------------IMAAVLVDEN
DSVRYFNPAAERLWGYARGEVLGRN---MRPLLPKALQAVHGSYMRSNREGGVGMNRDLLVERKDGRQLWVSFSLSKID--LSGRIHYLAFARDVSAEVA
RSEQNRLLLLAVNHTERPLFVVDGERRIVQINRAFSELFGYAAGEAVGCLPSELLASPHTAETLARVRSKAWGTEGFNEEILARSKDGRDMWVKASVNPI
FDEGQ-LRNQVIVMSDITEARRSRQRLDELVHHDALTGLPNRNSLYRYTNDLLASGV--EQEIAFFCIGLVRFKDVNNTLGYRVGDQMLVEIVNRLRSRL
SGGAFLARLEGSTFVLVVSECSPARAAQVASLLLQVISEPVGIAGVLLDLSACIGVSHYPDGCRDRDGLLQNAKSAMDQVKASGGGGCLFFSQGMNELAR
ERLLLGTALRRAIAGTGLRLEYQPQVRLDGGGLHGVEALARWHDPEFGEVPPGRFIALAEEIGEIEAVGQWALREACRQLAVWRGQGVHVPVVSVNLSPR
SFCSRALADAVAGLLREHALAGERLTIEITESAAMVLTPEMLETVHCIRALGVGLSVDDFGTGFSSLSNLASLPVTEVKIDRSFIDKCLEESRLRALVTA
VIGIGRSLDLTVVAEGVETGEQCELLRRQRCPVVQGYLFARPLRPQDVPPWVERFG----
>tr|A0A078LBA9|A0A078LBA9_CITKO cAMP phosphodiesterase OS=Citrobacter koseri GN=BN1086_00457 PE=4 SV=1
------------------------------------------------------------------------------------------FMAVVLVDER
NRVLFFNEAAEKLWGYSRDEVLGRD---MNILIPGPLKHVHGDYVHHHRDGGVGMNRELQLERKDGTQVWTSFSLSKID--VDGRIHYMAAARDVSKEVA
RREQNRLLLLAVNNTDRAVVVLDEQRRIVQTNRAFTSMFGYGADEAMNQVFPDFLLSSGNDDALKRVEEHLRGSRWFQEELLTATRNGREVWSRVSVNPV
LNEHRQTRNLVVTFVDITEERNGRQQIDRLVRFDALTGLPNRQYLYHHLDKLLS-GN--EPELAVFFLDINRFRKVNESLGYSAGDQVIITLANRLQERF
GPHHFISRVGGAQFVVVASACRVDEASHLAELMQHIVGAEMSAAGQTFELKACIGISHSI--GGDRETLLAHAESAMERVRESG-GSYQFFNPELNQAVM
QRLKLGMALRNAITEGHLRLEYQPQIRAADGQVYGFEALTRWHDPHAGDISPGTFIPLAEETGEIEHIGLWALREVCRQLFEWRKKGTNVSAVSVNLSAH
NFRKPDLPRYIADLLNEYQLPGNILTIEITESAMMELTDEMLARVREIRAMGAGVSMDDFGTGFSSLASLAYLPVTEVKIDKSFIDRFARDRRVNALVEA
VVSIGHNLDLTVVAEGVENTHQHQQLRKMGCSVLQGFLFSRPLSANTLPVWLEAYR----
>tr|A0A0A1PXW1|A0A0A1PXW1_9BACT Oxygen sensor protein DosP OS=bacterium YEK0313 GN=dosP PE=4 SV=1
------------------------------------------------------------------------------------------IDAVVMFGPD
DTVTFFNQAAERLWGYGRHEVIGRE---SSLLLSLPTPRRSP----------PGTSTELPVARKDGSIAWITLSLSDIRSD---LRFRAAFARDIT----
ADMQRRLPSLVADETDRAVIITDIRRRIVYCNRAFTTMFGYERSEVMGRSPTALLRGR------AHLNGLAGRERGLREEILGYTKSGREIWLSASINPI
RDQTGRFRHAVSVIADITEAKQAKAYIDQLAYYDTLTGLPNRLMLGARIDQTIATAAAGGRQLALLFLDIDNFKDVNDSLGHSAGDALLVEIARRLQAEL
RAGDIVSRLGGDEFVVMLNDCGIGDAAQVADRILGALADPVQVETMALPVSASIGISLYPRDGLNKEALLKHADTAMYEAKASGRGTHRFFSQDMNQLSQ
ERLVLGAALGDALGQGGLQLHYQPQVRAEDDALQGVEALARWHHPVLGNIPPDKFIAVAEETGLIEQVGEWVLGEACRQMAEWRQRGILIPTVSVNLSPL
NFRSRRLPDIVAAALQRHGLDARELTLEITEGVMMDQRADTTATVQAVHALGVRLSLDDFGIGYSSLSSITRLPIEELKIDRSFMRDLETDQNARAVASA
VIRIGHSLALNVVAEGVESEAQRRFLQALRCHVLQGFLYAKALPPRDLEAWVRRRG----
>tr|Q6N513|Q6N513_RHOPA Complete genome; segment 11/16 OS=Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) GN=RPA3170 PE=4 SV=1
------------------------------------------------------------------------------------------RDAAVIIDDG
GHICYVNQAAERIWGIGRADLVGSH---SDCLGVDAIQPEPVAGSH------SDLPLAIDITSRDNRSITAELTRSTIRVG---LNYTMLTVRDVT----
PELERRLLTSIADRTTRAVLVTDPELKLLYTNAAFTSLFGYSAEDAKGQNIIDLLSGR------AGLKRWIADAEGGEEEILVYDQNGDEIWISADVKAL
RNAQGRITQVFALLTDISETRQSRAQIARLAYFDMLTGLPNRARLRDLIADATAAC-PHGRTVALAFLDVDNFKDINDTLGHAAGDEFLVEFARRLRDQV
QPGDVVGRLGGDEFVVVLPNREPAEIEPVVARINEALMLPFALCNSQVPMSASIGVSLYPDNATDIDSLINQADTAMYRAKRSGRSTYRLFNCDMHGAAE
QRMAYAAALRSALANNRLELHYQPQIRTSDGALHGVEAMARWHDPVLGPVPPTKFIPLAEECGLIDQIACWSIREACRQMRVWRDQGLEVPSVSVNLSPI
NFENAALPTLVADTLATYHLPPEALMLEVTEGVAQDDRSAAHDTMAALRRIGVGLSLDDFGTGYSNLNRLAQLPIRELKIDRGFMSELETSPTARTVVTT
VVRVGQSLALSVVAEGVETTAQFQLLSDLGCDVAQGFLYAPALAPAAFEHWLLGYS----
>tr|D5QGR2|D5QGR2_KOMHA Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Komagataeibacter hansenii ATCC 23769 GN=GXY_11669 PE=4 
------------------------------------------------------------------------------------------NVGVVIVDDD
NA-VVFNDMAEHMSGHARDDVMGRH---SSTVLPME---IQTPLSQSGEKPL-GGLHTLSITRRDGTCFNAELEVSSLQ--MQGRRLHVITLRDVSPAEG
HVLGDGICATIVHETDRGILVLDGQSRIMHANPAFGTLCGYSEDEVAGNDFSILFSGHGRIRTLQQFRQQVGEGNSFEIDIQARRRDGTNIWLRAAATPV
HDDHGALEQTIIILSDVSRDRDARQSIDRLAHYDGLTGLPNRAWLRHYCTQ--ARQH--SLARVIMVLNLDRFQKINEAMGHAAGDTLLMEVARRLRHAL
LPDDILTRTDGDEFVIVTETAP-QQAAVQAERLLRILDAPLMIEQVELRPSASIGISISDGPSDEMKTVMKHAYSALSQAKEAGRNCYRFFSPEMNRAAE
DRITLAAALRRAIREDRLSLVYQPQVMTGSRHLHGVEALARWIDPELGFISPGRFIPLAEETGQIEILGEWSLRTACRQMTSWMMHGIDIPIVSVNLSAI
HFRDRNLPDTIARIMHETGMPPERLTIELTESTMIDNFEQTVEIVTAIRELGCGVSMDDFGTGFSSLSNLASLPVSEVKIDQSFMKGFEEAGKVYSVVRA
IVRIGQSLGMTVVAEGVETQAQYQLLRAMQCDVIQGYLFSRPLSPTDLAQWCITAT----
>tr|G2I3Y6|G2I3Y6_KOMMN Putative uncharacterized protein OS=Komagataeibacter medellinensis (strain NBRC 3288 / BCRC 11682 / LMG 1693 / Kondo 51) GN=GLX
------------------------------------------------------------------------------------------ILGVVLIDEN
NTVTFFNKAAEGLWHCVRQDVIGRN---VNILVPRNIRSTHDDLIRHNRETGVGTSREVLVERFDGTTFWANLSLSRIA--VDGKIGYMALIRDISQEVD
DREKIRLLSLVVRETDRGVAILDPEFRIIYVNRAFSDMFGFGPERVTGHGLSVILAGDTTIGILNQLHEGARNARGFTLDIRARHASGRDIWVSAAMNPV
FNNEGDIENIVVVLTDITEQHFAKEHINRLSDFDLLTSLPNRRWLRQNMARILRRAV--RGNIMLLTVGVDNFKHINDVFGHTAGDELITQIGGKLREAI
SIDDTLVRSGGDQFTIVTNGEQ-QHASTLSASILRALAVPTHIGDVPVSLSASLGVAVHPENGEDGDTLLKNAETAMFQAKANGGGHCCFFSPRMNQQAS
DRLILAAALRDAIAHDRLRLFYQPQVHACSGRLYGVEALSRWIDPSLGFVSPARFIAVAEETGQIEAIGKWSLRAACRQMAQWIRDGVEVPVVSVNLSPL
HFRDETLPRFVSELLEETGIPPHSLTIEITESTMIDNYDRTIRVAQRLREMGVGMSMDDFGTGFSSLSNLAGLPVNEVKIDRSFMTGLESIEKVRAVVMA
VVRIGQSLGMTVVAEGVEHEEQRRLLAEMECDVLQGYMFSKPLPAEELAAWFAAYQ----
>tr|D5QBM8|D5QBM8_KOMHA cAMP phosphodiesterase OS=Komagataeibacter hansenii ATCC 23769 GN=GXY_02611 PE=4 SV=1
------------------------------------------------------------------------------------------ILGVVLIDET
NTVTFFNSAAERLWNCTRADVLGRN---VNVLVPRKIRSSHDDLIKHNRDTGVGTSREVQVERFDGTSFWAELSLSRIS--VSGKIGYMALIRDISQEVA
DREKIRLLSLVVRETDRGVVILDPEFRLIYVNRAFTDMFGYEPSHVIGHGLSVILAGDTTISTLNQLHAGAQNDKGFTLDIRARHKNGRDIWVSATMNPV
FEDHGDIENIVVVLTDITENHFAKEHIAKLSHFDTLTGLPNRMWLRQHLDKMLRRPT--RGNFMLLSLGLDNFKNINDVFGHAAGDDLISYIATQLRDAI
GIDDTIVRSGGDQFTIITSGIQ-QHASSLSDMVLRLLSQPMQVGDVSVTFSASIGISVYPENGEAGETLLKHAETAMFQAKAHGGANYCFFSPKMNQQAT
DRLILAAALRDAIAHDRLRLVYQPQVHARTGKMYGVEALSRWNDPTLGFISPARFIAVAEETGQIEAIGKWSMRAACRQMAEWIRDGIDVPTVSVNLSPL
HFRDEKLPEFVAEVLEETGIPPARLMVEITESTMIDNYDRTIKAAQALRELGVGMSMDDFGTGFSSLSNLAGLPVNEVKIDRSFMNGLETVDKVRSVVTA
VIRIGQSLGMTVVAEGVEHEEQRQILVNMDCDVLQGYMFSKPLASDDLITWLAGYT----
>tr|A0A0D6QCX4|A0A0D6QCX4_KOMXY Diguanylate cyclase/phosphodiesterase OS=Komagataeibacter xylinus NBRC 13693 GN=Gxy13693_063_030 PE=4 SV=1
------------------------------------------------------------------------------------------DTGILLVSND
--NIFANDNAARIWGGPTPGLIGRK---LDILFPTGTDILPCTFGENLTNNVTQNHHHLTLLRHDGTTFSAEMSVARVE--GAGQQVFVISLRDVTRDLS
RREQDLQYASVVQRNACGILILDSQCRITYANASAARFSGIGTEGMEGADFSAFLSGQQGLATLQAFRRRLQRCRPFELEIHSRTDTGQDIWLLATVTPL
CSPYEELHEVIVVLNDITGSEQSREDIARLTQYDTLTGLPNRTGLRHGIRQRAARAR--RENLLALIINLDQFRAINNGLGRPAGDRLLAALARRLSGLI
SSDDLLARSGGDEFTLITTGGV-ERATALADTVMKTVAEPVVIDMVPVTITASIGIADNDGGRREMEILMQQAETALSQAKNADRNCYRFFSEEMNRQAA
DQILLANALKQAIRTDQLYLVYQPQVHAATGRLEGVEALARWTDPALGMISPGRFIPLAEETGQIEAIGLWSLRAACRQMALWMQAGVDVPVVSVNISAL
HFRNPDLPRLIGEILHESGIPPQRLTIELTESAMIENYDQTLIAAQAIRAMGIGLSMDDFGTGFSSLSNLANLPLNELKIDRSFMDGFEPTGKVHSVVTA
IIRIGRSLGMTVVAEGVETQAQLDLLRQINCDVIQGYFFSRPLDVQDLEAWLKARP----
>tr|A0A0D6QDS6|A0A0D6QDS6_KOMXY Diguanylate cyclase/phosphodiesterase OS=Komagataeibacter xylinus NBRC 13693 GN=Gxy13693_081_004 PE=4 SV=1
------------------------------------------------------------------------------------------PMAVMMADVS
GRVVYGNPRACDLTGYTPTDLAETR---LGRLFPDQTVDVTTPLD-----PSTADDGTTTLRRRDGLGVPVRLYRDSIS--WDGALYELVALLDLTEEEQ
ARENAEISALIVQATDRGILVLDPQYRITHANRAITDLMGMEPAALHDAPFGTLLSGGDSITTLRQFRQHLARRTGFELDIHTRGQQGRDLWLRCAVTPH
YGDDGRLADIIVILHDITHDRQSRDSIIRLSYTDRLTCLPNRMWLNRRMQELAARPP--AAPLSIMVIDLDRFRKIVQALGQGRADQLLLELATRLRNAM
VGRDVLVRTEGDEFVVLTEENA-PDVTLLAERIIHNLEDPFTVDGIPVSISGSIGISTFSGEGQDAEECLRQAYTALAQAKKAGRCCYRFFHPSMNRQAD
DHVILASALREAIADSRLTLVYQPQVNLRTGELHGVEALSRWDDPVLGMVSPGRFIPVAEETGQIRALGAWSLRVACEQMAEWIARDIPVPTVSVNMSAI
QFQDPELVSQLATILHQTGVPPERLIVELTETAMIENFDQTVTTATAIRNLGIGLSMDDFGTGYSSLSNLASLPISEVKIDRSFMNGFGSTGNVRQVVTA
IIRIGHTLGMTVIAEGVEDAAQCAGLRDIDCDVVQGYYFGRPMTTASLDTWIRERR----
>tr|A0A070AA07|A0A070AA07_9PROT Oxidoreductase OS=Komagataeibacter rhaeticus AF1 GN=GLUCORHAEAF1_00185 PE=4 SV=1
------------------------------------------------------------------------------------------PLAVMMADVS
GQVIYANACASRLTGYDPAGREEKW---LGRLFPEPMRPTGTPAAWDAHIGATRNGSSATLRRRDGLGLPVRLWREGVD--WDGVPYELITFQDRTEEEQ
AREDGAISALIMQATDRGILVLDPQYRITHANRAVASLLGMTVDALRHAPFGTLLSGAESIGTLRQFRRQLSLRTGFELDVHTRGPQGTDLWLRCAVTPH
FGDDGALADIIVILHDITHDRQSRESIIRLSYTDRLTGLPNRAWLHRRMAELAARPP--VVPLSVLIIDLDRFRKIVQALGQGRADQLLLELADRLRHGI
VGRDVLIRTEGDEFVVLTEESS-ADITLLAERIIHNLEEPFSVDGIPVSLSGSIGISTP-DDGQDMEERLRQAYTALAQAKKAGRCCYRFFHPSMNRQAD
DHVILASALREAIADNRLTLVYQPQVDLRTGALHGVEALSRWNDPVLGMVSPGRFIPVAEETGQIRELGIWSLRVACEQMADWIARGIQVPTVSVNLSAI
QFQDPELVAQLGAILHQTGVPPERLIVELTETAMIENFDQTVATATAIRNLGIGLSMDDFGTGYSSLSNLAGLPISEVKIDRSFMNGFGSTGNVRQVVTA
IIRIGHTLGMTVIAEGVEEAEQCNQLRAIGCDVIQGYYFGRPMDTAALDTWISERR----
>tr|G2I7A5|G2I7A5_KOMMN Diguanylate cyclase/phosphodiesterase OS=Komagataeibacter medellinensis (strain NBRC 3288 / BCRC 11682 / LMG 1693 / Kondo 51) G
------------------------------------------------------------------------------------------PLAVMMADVS
GRVVYANRQAIILTGHDPANQEEIW---LGRLFPEQMQHANTPAAWEGTPGPTRQESCATLRRRDGLGLPVRLWRESVD--WDGTLHELIALQDRTQEEQ
AREDAAISALIMQATDRGILLLDPQYRITHANRAVTSLLGMQPDALRNAPFGALLSGAERIETLRQFRQNLAHRIGFELDVHTRGPQGTDLWLRCAVTPH
FSAEGELTDIIVILHDITHDRQSRESIIRLSYTDRLTSLPNRTWLNRRMAELTARPP--AVPLSVLIIDLDRFRKIVQALGQGRADQLLLEFASRLRQGI
VGRDVLIRTEGDEFVVLTEESS-ADITLLAERIIHNLEEPFSVDGIPVSISGSIGICTH-DDGHDVEELLHQAYTALAQAKKAGRCCYRFFHPSMNRQAD
DHVILASALREAIADNRLTLVYQPQIDLRTGELHGVEALSRWNDPVLGMVSPGRFIPVAEETGQIRELGLWSLQVACEQMATWIARGVMVPTVSVNLSAI
QFQDPELVSRLATILHRTGVPPERLIVELTETAMIENFDQTVTTATAIRNLGIGLSMDDFGTGYSSLSNLASLPISEVKIDRSFMNGFGSTGNVRQVVTA
IIRIGHTLGMTVIAEGVEEAEQCQQLRAIGCDVIQGYYFARPMDTASLDAWINERS----
>tr|B5ZGV8|B5ZGV8_GLUDA Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Gluconacetobacter diazotrophicus (strain ATCC 49037 / D
------------------------------------------------------------------------------------------PGGVVVTDAD
GRILFINRAAARLCGGQPEEWASRS---LAVLLPDMDMT-------------DGTPREVRLAGRDGAALWLEVTLNRGGAEETPREIRVAALRDVTDEVA
RRTAAHLFSTIVNHAGRGVMVLDDRDRIVYVNPAFTRLLDYRPEDVVGRDVSVILSPDVDRAALGEFRRDLHGRRTFGRDLHARSRSGQDIWMSTATSPV
RDGGVLDGGAIVILSDETPATEARAQIAHLAHYDAVTGLPNRTWLREHLAARQGAAN--WCGLTLMSVDVNRYREIRDALGGAAADEVLGGIAKRLRAVV
GQDDILVRTGEDEFSILTDCGHVDRASTLAGAILRALASPVVVNGMPIGSPISIGICAGRDKGRTVETLLRHTQIAVSRAREAGGSLYRFFSPEMNRWAQ
DRVMLASALGDALADGRLRLVYQPQVRSRSGALYGVEALARWHDPEWGDIPPTRFIPMAEEAGLIEALGEWALRQACRQMAIWMAHGVGIPVVSVNLSAR
HFSDPGLPGLIGSILEESGIPPGRLMVEITESTMITDSETTIAAARAIRALGVGLSMDDFGTGFSSLANLVSLPLSEVKIDRAFVVGLERAGDTYSIVNA
VLRIGQSLGVTVVAEGVETQRQLDLLDGLDCPVVQGFLMSRPLDAGKVPSWLEEWH----
>tr|A0A0D7NUD9|A0A0D7NUD9_9BRAD Diguanylate cyclase OS=Bradyrhizobium sp. LTSP857 GN=UP06_24300 PE=4 SV=1
------------------------------------------------------------------------------------------DDGIVIVDGA
HRITHFNAGAERIWKLARTEVLGRD---AEVLTLKCLQAD------------TDFRDEISLVRRDGSRIRATVALSSATIG---ATHHIVFARDVT----
AEAERRLLNAVSDQTNRVVIVTDVEQNIRYVNAAFTALFGYTNDQAEGRRATELLAGC------AKLVKLMHGGRRGEVEVLAYDKNGEEIWVAARIDAF
RDKKGRVKHIFALLEDITETRQARAEIARLAYHDILTGLPNRAQLRHLITTAIDAC-PTSSHVALAFLDVDHFKDVNDTLGHAAGDELLIQLAQRLREHI
GPEDMLGRLGGDEFVVLLPYRNAEGAERVAAEITEALAAPLRLGSRQLQMSASIGISLYPDHATDIDTLMQQADAAMYMAKQAGRSTHRLFSAEMNGLTE
QRLALIAALRRAIAEGALTLSYQPQIRSCDGAIHGVEALARWHDAVLGDVSPAKFIPLAEECGLIEQIGLWSVREACHQMASWRRAGLNIPTVSVNLSPL
NFRNVTLAARLADILAEYKLPPDALMLEITEGTFMQDGATALETMHAIRALGVGLSVDDFGTGYSSLSRLAHLPIRELKIDRSFMRDIDKDAGALAIATA
VVRVGQGLGMTVVAEGVETEGQRKMLAELGCDVVQGFLYAPALPPVAFERWLIEHC----
>tr|J3HWN1|J3HWN1_9BRAD PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Bradyrhizobium sp. YR681 GN=PMI42_07376 PE=4 SV=1
------------------------------------------------------------------------------------------DDGVVIVDDA
HRITHFNGAAERIWKLARAEVLGRD---AEILTLRCLQAE------------VGFRDEISLVRGDGSRIKALVTVSPATVG---ETHHIVFARDVT----
ADAERRLLHAVSDQTNRAVVITDVEQNIVYVNSAFTALFGYTSKEAEGRRAAELIAGR------AKLVKLMTGGRRSEIETLAYDKDGGEIWVCARIDAF
RDKKGRVRHIFALLEDITETKQARAEIARLAYHDILTGLPNRAQLRNLITTAIDAC-PTGSHVALAFLDVDHFKDVNDTLGHAAGDELLIQLAQRLREHI
GPEDMLGRLGGDEFVILLPQRTAEGAERVAAGITEALSAPLRLGSRQMQMSASIGISLYPDHATDIDTLMQQADAAMYMAKQAGRSTHRIFSAEMNGLTE
QRLALIAALRKAIAEGALTLSYQPQIRSCDGGIHGVEALARWHDAVLGDVSPAKFIPLAEECGLIEQIGLWSVREACRQMADWRRAGLNIPSVSVNLSPI
NFRNVTLAARLKDILAEYDLPADALMLEITEGAFMQDSVAALETMNAIRELGVGLSVDDFGTGYSSLSRLAHLPIRELKIDRSFMRDIERDAGAVAIATA
VVRVGQGLGMTVVAEGVETEGQRRTLAELGCDIVQGFLYAPALAPVAFERWLIEHC----
>tr|M4ZH18|M4ZH18_9BRAD PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Bradyrhizobium oligotrophicum S58 GN=S58_71230 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------MRELTLKHDDGSRDWVRLSASDLSSQ---PRHWLVMVRNVT----
SEIELRLLTSVADRTNRAVIVTDRDLTILYTNAAFANLFGYTPEQSIGRRAEELLIGP------DRLRQCADDDRGIEEDVLVYDKDGHELWTTAYVKAH
RTRRGKVKYLFGLLTDIRETKQVRSTISQVAYHDMLTGLPNRARIPSLIAEAIKAC-PAGGHVAVAFLDADNFKDVNDTLGHAAGDEFLVGFANRLRAQI
RNGDMLGRLGGDEFVIVLQNRDPLEASLAAARITAALAMPLTIGKRQVPMSASMGLSLYPDNAKDIETLIKQADAAMYKAKRGGRATYRFFSADIDKLAE
ERLMHSTALREAIASEALTLHYQPQIRTRDGAIHGVEALARWHDPVLGEVSPSKFIPLAEECGLIEQIGVWSIKLACQQMASWRRARLDIPCISVNLSPI
NFQNVNLAAMVAQILAANDLPAKMLMLEITEGVILNERATVIATMNELRNMGVGLSLDDFGTGYSSLSRLAQLPIDELKIDRSFMRDFENDNGTRAIVTA
VVRVGQSLDVAVVAEGVETEPQRRLLAELGCDAMQGFLFARPMAASAFSRWLLDYS----
>tr|I0G2L4|I0G2L4_9BRAD Uncharacterized protein OS=Bradyrhizobium sp. S23321 GN=S23_17850 PE=4 SV=1
------------------------------------------------------------------------------------------DDGIVVVDDA
RRISHFNASAERIWKLARAEVLGRD---AGVLGLPFLQAD------------ADFRDEISLVRPDGSRIRASVSLSSTTVG---ATHHILFARDVT----
AEAERRLLNAVSDQTNRAVMITDTEQNIRYVNASFTALFGYTSEEAEGRRAGELIAGC------AKLFKLIDGGRRGKVETLVYNKDGEEIWVCARIDAF
RDKKGRARHIFALIEDITETRQARAEIARLAYHDILTGLPNRAQLRHLITTAIDAC-PNGSHVALAFLDVDHFKDVNDTLGHAAGDELLVQLAQRLREHI
GPEDMLGRLGGDEFVILLPQRNAESAERVAAGIMEALAAPLRLGSKLMPMSASIGISLYPDHATDIDTLMQQADAAMYMAKQAGRSTHRIFSAEMNGLAE
QRLALIAALRRAVAEGALTLNYQPQIRSCDGAIHGVEALARWHDAALGDVSPAKFIPLAEECGLIEQIGLWSVREACRQMASWRSAGLNIHSVSVNLSPI
NFRNVTLAARLKDILAENALPPDALMLEITEGTFMQDGAAALETMHAIRALGVGLSVDDFGTGYSSLSRLAHLPIRELKIDRSFMRDIERDAGAVAIATA
VVRVGQGLGMTVVAEGVETEGQRKVLAELGCDVVQGFLYAPALPPVAFERWLIEHC----
>tr|A5ETK5|A5ETK5_BRASB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182) GN=BBta_7654 
------------------------------------------------------------------------------------------SEAILFLDAE
GRVHHANQAAVALLRRDLKDLIGAD---LDRLGLPAEQLRAMTKSEAE----GDAGREMMLRHADGSRCRVRAIVRDLPSA---PMHSLLLLRDVT----
SDVEMRLLTSVADRSNRAVIVTDHELKILYTNAAFCSIFGYSSAEVLGRQVETLLVGP------ERLKQCVEDDRGVEDDLMIYDKAGCEIWTTAHVKAH
RNQRGKVKYLVGLLSDIRETKQVRSTISQVAYHDMLTGLPNRARIPSMIAEAINAC-PEGSHLAIAFLDADNFKDVNDTLGHAAGDEFLVAFANRLRAQI
RPGDMLGRLGGDEFVIVLQNRDALEASLAAARITAALAMPLTIGKRQVPMSASMGLSLYPDNATDIETLIKQADGAMYKAKRAGRATYRFFSADIDKLAE
ERLMHSTALREAIASEALTLNYQPQICTRNGAIHGVEALARWHDPVLGEVSPSKFIPLAEECGLIEQIGVWSIKQACQQMASWRRAGLDIPCISVNLSPI
NFQNVNLAAVVAQILAANDLPAKMLMLEITEGVILNERATVIATMSELRNMGVGLSLDDFGTGYSSLSRLAQLPIHELKIDRSFMRDFENDQGTRAIVTA
VVRVGQSLDVKVVAEGVETEPQRRLLAELGCDAMQGFLFARPMAAGAFSRWLLDYS----
>tr|H0S8P7|H0S8P7_9BRAD Putative diguanylate cyclase (GGDEF)/phosphodiesterase (EAL) with PAS and GAF domains OS=Bradyrhizobium sp. ORS 375 GN=BRAO375_
------------------------------------------------------------------------------------------SEAILFLDGH
NRIHFANRAASALLRREPAALIGAS---PESLGLPADLAAATAGDKQGG---DAEPREVTLRHADGSRNRLRCRLSALSPA---PVQSAVFLQDVT----
KDVVLRLLMSVADRSNRAVIVTNPELKVLYTNAAFASIFGYSSQEVLGQDVEKLLVGP------DRLKQCIIDDQGVEEDLLIYDKAGCEIWTTAHVKAH
RNHRGQVKYLVGLLSDIREAKQVRSTISQVAYHDMLTGLPNRARIPSMIDEAIKAC-PEGSHLAVAFLDADNFKDVNDTLGHAAGDEFLVGFANRLRAQI
RPGDMLGRLGGDEFVIVLQNRDALEASLAAARITAALAMPLTIGKRQVPMSASMGLSLYPDNAKDIETLIKQADGAMYKAKRAGRATYRFFSADIDKLAE
ERLMHSTALREAIASEALTLHYQPQICTRTGAIHGVEALARWHDPVLGDVSPAKFIPLAEECGLIEQIGVWSIKTACQQMASWRRAGLDIPCISVNLSPI
NFQNVNLAAVVAQILAANDLPAKMLMLEITEGVILNERATVIATMSELRNMGVGLSLDDFGTGYSSLSRLAQLPIHELKIDRGFMRNFENNQGTRAIVTA
VVRVGQSLDVKVVAEGVETEPQRKLLAELGCDAMQGFLFARPMAAGAFSRWLLDYS----
>tr|H0RWX7|H0RWX7_9BRAD Putative diguanylate cyclase (GGDEF)/phosphodiesterase (EAL) with PAS and GAF domains OS=Bradyrhizobium sp. ORS 285 GN=BRAO285_
------------------------------------------------------------------------------------------SEAILFLDAR
GRVHHANNAAAALLRRDLATLIGAE---LADLGVPADAMPAPLEDEEPA--DADFACELTIRHEDGSRNRVHLTRYELPAT---PVRSLVLMRDVT----
SEVQLRLMTSVADRSNRAVVVADHDLNILYTNAAFTSIYGYSAEEALGQQVEKLLVGP------QRLKQCIVDDQGVEEDLLIYDKAGHEIWTTAHVKAH
RSRHGKVKYLVGLLSDIRETKQVRSTISQVAYHDMLTGLPNRARIPSMIAEAIKAC-PEGSHLAVAFLDADNFKDVNDTLGHAAGDEFLVGFANRLRAQI
RPGDMLGRLGGDEFVIVLQNRDALECSLAAARITAALAMPLTIGKRQVPMSASMGLSLYPDNATDIETLIKQADGAMYKAKRAGRATYRFFSADIDKLAE
ERLMHSTALREAIASEALTLHYQPQICTRNGAIHGVEALARWHDPVLGEVSPAKFIPLAEECGLIEQIGVWSIKTACQQMASWRRAGLDIPCISVNLSPI
NFQNVNLAAVVAQILAANDLPAKMLMLEITEGVILNERATVIATMSELRNMGVGLSLDDFGTGYSSLSRLAQLPIHELKIDRSFMRDFENDQGTRAIVTA
VVRVGQSLDVKVVAEGVETEPQRKLLAELGCDAMQGFLFARPMAASAFSRWLLDYS----
>tr|E3G435|E3G435_ENTLS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Enterobacter lignolyticus (strain SCF1) GN=Entcl_0775 PE=4 SV=1
------------------------------------------------------------------------------------------ILGVILIDEL
DKIIFFNSAAEELWGYRRDEVLGQN---VSVLVPSSLRTAHPQYIQHNREGGEGMSRELLLERKDGSGLWTRFALSRFS--ASGKTGYLALVRDASQEVI
QREQSRLLLLAVDHLTKPVVVMDPEFHIVQFNRAFAGLSGLSGHDVMGKRLDEALTIPASTREQQKLQKLLHNNVRSREEFQAVDGSGEAVWLNASLNPI
FDKDNQVQNLVVTFYDVTEERKSRQQIDSLIKFDRLTGLPNRNHMHHFLDQLILNGE--GAAPVIFLMSIDHFQDVIDSHGYAVADQVLVTVANRLSGIL
RPGQYLCRTEGAEFVLIDQESDLSNMTRVSEALEHLISASFQIDGLSFFLTLSIGISHEA--GRSQDWLLSTAHRAMELVRKTGGNNREFFSPELSKAVN
ERLLLGAALKRAVSDSHLRLVYQPQIYANTGALYGCEALIRWNDPEHGEVPPSRFIPLAEETGEYEEIGLWVIREACRQLAEWRALRIDIPVISVNLSAR
HFQNRRFPDQVLSVMKEFGIPGEQLMLEITESMMLTDDEEVLRRIQILRNAGLGLSIDDFGTGFSGLSRLARFPVTEIKIDKSFVSGYPEDNRQRSLLEA
IIGIGQSFSLNVIAEGVETSEQFQLLRELGCPVIQGYYYSRPIPASEIPGWYRRVS----
>tr|A0A084ZPD6|A0A084ZPD6_9ENTR Sensory box/GGDEF family protein OS=Trabulsiella guamensis ATCC 49490 GN=dosP PE=4 SV=1
------------------------------------------------------------------------------------------IIAVVLVDEK
NRIVFFNPAAEKLWQFSREEVVGQD---MKILLPPSLQYNHKVWIQRHREGAVGMNRELQLERSDGKKVWAVFSLSKVD--VNGRIYYMAMARDVSDEVA
AREQNRLLLLAVNHTVHPIIVLDIQHHILQVNKAFTTLTGLSVPDIVGKKAMALLPVQKKKNISDRFTRLLKQNDWFQEDIPVSCADGAVMWFSAQIDPV
SDGDGKLRNQVLALTDITREREKRQQIERLIQTDALTGLPNRSSLNHYIDRLFESTS--VSQLSTFSFCIDNFSEINDSMGYAVADQLLLLMVIRLQSVL
EPGYFLSRTEGIQFILVVPECDIILSSKIAQDLEKIAEKPVVLGGNTFSITFSIGISHYPEC--SRDELLSGAKMAMEHVRATGGNRWQFFNHETDRMVR
ERILMKRALKEAIEGNELRLEYQPQICADDNTVYGFEALARWHSPSYGEVPPYKFITMAEETGDIKALGEWVIREACRQMAEWKLSGVRIHSVSVNLSAL
NFRCPYLPSVIAGLLKEYHLPGNMLTIEITESAMLEFDSGILKRIQEIRDLDVGLSIDDFGTGYSSLSRLTGLPVTELKIDKSFIDRFQYDEKVAVLVKA
ITGIGRSMGMSVVAEGVETKDQLELLKKIGTIVIQGYYFSRPLPADMVPDWLTLYA----
>tr|H0TQ76|H0TQ76_9BRAD Putative diguanylate cyclase (GGDEF)/phosphodiesterase (EAL) with PAS and GAF domains OS=Bradyrhizobium sp. STM 3843 GN=BRAS384
------------------------------------------------------------------------------------------SEAVVILDSD
LCVHHANAAAERLFRADGAALVGSD---VSRLGIPRDHAIFRAPAGADH--ASPRPVEIKLRPADGSCICVSLTLSRLEIG---TIWLALFARDVT----
AEVERRLLHSVADRTNRAMVVTDHELKIIYTNAAFAEMFGYQPGEAIGRRADELMVGP------EKLKLWLAEDRGGEEEVLVYDKSGREIWVTAYVKAH
RNRRGAVKYLVGLLSDISESKQAMSAVARMAYYDMLTGLPNRAHIRSLIATALEAC-PEGGHVAVAYLDADNFKDVNDTLGHAAGDEFLIAFAKRLRGQL
RPGDMLGRLGGDEFLVLLPNRDSIEASLMAARITAALAVPLTIGSRQVPMSASMGLSLYPDNASDIDTLIKQSDAAMYKAKSAGRATYRFFSADLDKIAE
QRLMHSTALRDAVANEALKLYYQPQIRSRDGAIHGVEALARWHDEVLGDVSPAKFIPLAEECGLIEQIGLWSMREACRQMAAWQRAGLDIPSVSVNLSPI
NFQNVNLAARVAQILNEYGLPPKRLMLEITEGVFLNERATVVATMNELRNLGVGLSLDDFGTGYSSLSRLAQLPISELKIDRSFMRDVEDNPGTRAIVTA
VVRVGQSMNLAVVAEGVETEGQRHLLDELGCDALQGFLYARPLPATGFGRWLLEHS----
>tr|Q2IV34|Q2IV34_RHOP2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodopseudomonas palustris (strain HaA2) GN=RPB_3230 PE=4 SV=1
------------------------------------------------------------------------------------------RDAVVIVDHD
GHLRYVNAAAESTFGLDRTGLLGRA---VGALGHDELGARIVQAAFAA----GQAGFEITIGRQDRRAVRAAVSVSRAQVS---GDYAIAFVRDIT----
QEVEQRALMTVAERASRAVLVTDRDDIIIYTNPSFTRLFGYSAEETKGRHAGELLAGR------ASPAPD-IDDEGSEQQILLYAKDGGEIWVSAEVKGL
RDGRG-----VALLTDISESVQARAQIARLAYYDMLTGLPNRARLRDLIAQATGTC-PPGQHVALAFLDVDNFKDVNDTLGHAAGDDFLVAFAQRLREQI
RPCDMLARLGGDEFVIVMPGRNASEAGLVASRIAEALALPLGIGTWQVPMSASIGISLYPDNATDIDVLIRQADTAMYQAKRSGRSTYRFFSEDMNGAAE
ERMAYSAALRNAITFDLLELHYQPQIGTRDGAIHGVEALARWNDPVLGAVSPAKFIPLAEECGLIEQVALWSIRAACRQMAAWRALGLDIPCVSVNLSPI
NFQNPNLADLVSDILAELRLPPEVLMLEVTEGVIQNERSLAIETMNALRRLGVGLSLDDFGTGYSSLSQLAQLPIRELKIDRGFMRDIAHQSSARAVVTA
VVRVGQSLQLSVIAEGVETDEQFALLAELGCDAVQGFLYAPALTPAAFELWLVDYS----
>tr|A7IPE4|A7IPE4_XANP2 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
------------------------------------------------------------------------------------------TDAVVFLDET
GVITFVNAAAEHLWGLSAAAMVGRN---ARVVFPAALRFDPAL---------VGADWQVVITRPDGSSAFALVRLAQVWHK---AGYAAV-VHAM-----
DPTGAAILSLVAEKTDRGVVVTDARHRIVYTNRAFQEMLGYVEGEAEGRVLEDLLATG------ARISSGIQRRMPFPEDVPLRGASGNEVWVSAIVTPV
LNQTGALEHVVAVLADITHARLARDRIATLASIDALTGLPNRRRLIESLGDLIAEAAERDEPLAVMMLDVDHFKDVNETLGHSTGDELLVEMARRLQAQL
RTGDTVGRTGGDEFVVVVHDCAAEEAARIARRLIDYLSAPIPAQKLHLTMSASVGIALYPQHGTSAETLLRHADTAMYEAKSKARGRFQFFTEDLNKRVE
DRLVLSVALREAVQNQALRLVYQPQVTLAAGGLHGVEALARWSDPVHGEVPAPRFIALAEEYGFIESIDQWAVEEACRQIAVWRAEGVAVPHVSVNLSPL
SFRSGEIVGIIADALERHRLAPSDLRVEITERVTMDQNPHSFATARAIDALGVRIAMDDFGTGYSSLSALSRLPIAELKIDRSFMLSIEQDKNALALATA
VILIGQSLGMAVVAEGVETAAQADLLRTLGCHAVQGYLFARPLEADAVAGWLAANA----
>tr|E6VCP2|E6VCP2_RHOPX Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Rhodopseudomonas palustris (strain DX-1) GN=Rpdx1_2255 
------------------------------------------------------------------------------------------RDAAIIIDDG
GYICFFSQTAERFWGIGRAELIGCH---CDLLGINAM-LEPIAGSH------SELTVEIEITSRDGRSITAELTRSTIGAG---CDYTLLTVRDVT----
PELERRLLTSIADRTTRAVLVTDPELRILYTNAAFAVLFGYGADEAKGRNIIDLLAGH------AGLKRWMADDEGGEEEILVYDKNGEEVWISADVKAL
RDPQGRITQVFALLTDISETRQSRAQIARLAYFDMLTGLPNRARLRDLIGEATAAC-PQGRSVALAFLDVDNFKDINDTLGHAAGDEFLVEFARRLRDQV
QPGDVVGRLGGDEFVVVLPNREPAEIEPVVARISDALMLPFALCNSQVPMSASIGVSLYPDNATDIDTLINQADTAMYRAKRSGRSTYRLFNCDMHGAAE
QRMAYAAALRSALADSRLELHYQPQIRTADGALHGVEAMARWHDPVLGPVPPAKFIPLAEECGLIDQIACWSIREACRQMRVWRDQGLEVPSVAVNLSPI
NFENAALPTLVADTLAGYHLPPEALMLEVTEGVAQDNRSTAHETMVALRRIGVGLSLDDFGTGYSNLNRLAQLPIRELKIDRGFMSELEISATACAVVTT
VVRVGQSLALSVVAEGVETKAQFQLLSELGCDVVQGFLYAPALAPERFEEWLLGYS----
>tr|F4AUH3|F4AUH3_GLAS4 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Glaciecola sp. (strain 4H-3-7+YE-5) GN=Glaag_4393 PE=4 SV=1
------------------------------------------------------------------------------------------TLPIILLDGM
GAICSFNLGAATLFGITAKHAVGKN---INALCSDITMPV---NVQGNTQ---TYELKARITR-TSKSHWLRITSSKAPNE---DSSVLMIIRDITNEIE
SRKQQNLFQTVTDYFDKALMILDCDYKVIQINKAFTNIFGYTSSEIYGLRPRDKLFKETISEDERK-------KEPFDFTVSTLTKTNQEVWANFTCSQM
SEDIDEKAYYVVFISDVTQAKQALTKIDRLTQYDSLTGLFNSRYMEQFVHQELS--N--TDEVAVISLGICNLELITEPCGSQAADRVILETAKRLKTTA
GRASHISRAESGEFFLVTKLMDMDSLRMLCEVLLGSTTQVLEVNEYSIEIETCAGIAFGQA--ENFKALCDQAHIAK---NRAHIGTYGFFDEGMNGVSK
ERLLLSYSLKKAINDSQLKLFYQPQVCLKTMRVMGVEALARWYSSEHGNVSPEKFIQLAEKIGEIDRVSMWAIKAACEQMAYWRTIGVSVPTVSVNLSQL
NLNIDGLDQYVDRILKSYHLPASCLILELTETATSELTPSKMNMILALRDIGVRLSMDDFGTGFSSLANLASLPVSEIKIDKSFVQAIATDERFNVLVSS
IIDMGNKLGLTVVAEGVESKQQLDLLRSYNCPIIQGFIYSKAVSADELTLLVKKNT----
>tr|A0A080NJL4|A0A080NJL4_DELAC Diguanylate cyclase domain protein OS=Delftia acidovorans GN=DR66_2410 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------TYAPVLDA---LSHVLCIATDITARVQ
ADRRRQRLSLVADATDAAVVIADGNWTISYVNAGFTRMFGWSSEEVVGRAPIALLVPH------AAYRAELDAGKPVYREEILVGKDGERYWVSAQANPV
MGPDGRLHTTVTVITDITEAKMARRRIRQLAFYDGLTTLPNRSLLLAQAEQALSVASHEGHELAVVFIDLDRFKQVNDSLGHPAGDRLLCSVAQRIQAEL
RTGDIAGRLSGDEFVIVLPHCGGAQAAEVIERLQSALGEPCMID-VSLASTASCGIAVFPADGRDMETLLHRADMAMYQAKSGGRGLYSFFSPEMNRLAQ
ERLVLETALRDALRSGGLRLHYQPQLDLKDGRLYGVEALARWSHAEFGEISPARFIPLAEECGLIGELGTWALREACRQLGEWRSRGIDVPAMSVNLSPT
SFHNLDLPRMIADTLEHNALKPQDLTLEITESLLLDTNPGTMRTLQAVHSQGVRVSMDDFGTGYSSLSYLRRLPVSELKLDRSFVADLENDEAAQALSNA
ILGIGRSLHLTVVAEGVETAAQNTILREQGYPVAQGYLFSRPLPAADLERWLQASS----
>tr|A0A096FFQ6|A0A096FFQ6_COMTE Diguanylate cyclase OS=Comamonas testosteroni GN=P353_15295 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------NYSPVLDH---VVGVVKVAIDVTERVR
REHLLQRLALVADATDNAVLLLDDAWKISNVNTGFTRMLGWSREEVLGRNSIDLLCIS------ALYSQQLMTGQVVRREELVHGRDGQRYWVRVASHPV
MNAEGVIEQVVTVLGDITGKKLSRSMIRQLAFYDGLTGLPNRSLLLAKADHVLTDASREATSFAVLFIDLDRFKQVNDSLGHPAGDTLLRDVALSIRQGL
RGMDILGRLSGDEFVVVVPQVDVPQITDRVEKLQVLLSSSKTLD-VTVSPSASIGIAMFPSDGRDMETLIQRADMAMEQAKASGRGRFRFFSLEMNELVQ
QRLLMESLLHDALKHKRLRLAFQPQVDITTGHLSGVEALARWSDPVLGEVSPARFIPLAEECGLIGELGAWALQEACRWLGRWREEGLRIPSVSVNLSPS
SFHNLALPDLIARTLDEHHLEPKDLTLEITESMLLDSNPSTLKTLAEVHCLGIKISMDDFGTGYSCLSYLRRLPVSELKLDKSFVADLEGDAAARALSHA
ILRMGESLQLTVVAEGVETEFQYRLLKEQGYHVAQGYLISKPLAPEDFGQWLSANG----
>tr|E6WUF7|E6WUF7_PSEUU Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Pseudoxanthomonas suwonensis (strain 11-1) GN=Psesu_210
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------LYAPVHDV---VTHIMVVATDVTQSKR
TELARQRLSLVADTTDAAIVITDANSRVVYSNGGFFRMFGWTLGEMQGRKVLELLAQQ------ERVRGDLRQGRPAGMEEVVTGKGGRRYWSKILCNPV
MDAEGNWAYTVSVLLDITKTKIARQRIQQLAFYDALTGLPNRSLLETQAAQLLESAQEIGQRVAVLYLDLDRFKHVNDSLGHAAGDALLREVAARIRGLL
RQDGVAGRLPGDEFIVAVPLRSGEEINSLIERWQTRLMRPLQLS-TKVDLSVSMGVAMYPEDGAAMGTLLHRAEMGVHQAKAGGPGRVGFFSVELSRAAG
ERLALETALREALQGGGLQLHYQPQVALATGRLYGVEALARWEHPELGSIPPSRFIPLAEECGLMGALGRWALDESCRQLAQWRREGLVVPNMAVNLSAS
NFHNLELPAIVAQTLETHGLQGSDLLLELTESILLDSHGAVMQTIERLHAQGVGLSMDDFGTGYSSLSYLRRLPITELKLDRSFVADLENATTARALSAA
ILGIGTSLGLTVVAEGVETEAQREILKAQGYPVVQGYWFARPMPPQELPGWMAGQG----
>tr|J3DIG0|J3DIG0_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Herbaspirillum sp. CF444 GN=PMI16_00775 PE=4 SV=1
-------------------------------------------------------------------------------------------LGVIEFSAD
GIIVGANSNYLKTMGYLPEEIVGKH---HGFLCEPEYVAS----------QERFFSGRFKRIARDGRPIWWEATYTPVLDQ---PIKIISIGSDVSYRMV
REQRDRLLSLGINETDNAVFITNDANHIVFHNTGFSRMLGFAADEVIGKRPRELFEGQ------DDCYDVIAQGNSFHGEEMMVDKQGHPLWVSTVVNPI
LDGDGKLINAVCILTDITNTKMTRSRIHQLAFYDSLTGLPNRSLLMVKANQAIANAARTRVPLAVLFIDLDRFKQINDSLGHQAGDELLRTVAARLQIEA
RKSDIVGRLSGDEFVIVLSQCDLHRVTDVVKRIQANLSQPCHIAGVALTPLASIGIALFPDNGDTIEILLHRADMAMYQTKEKNRGRFSFFSDDMNTQAQ
ERLALEGALRDALRGGDFELHYQPQIDVCTGLLHGVEALARWHHDQLGQVSPARFIPIAEECGLIGELGKWALEEACFQLNDWRKRDIKVPSVSVNLSST
NFHDLDLPQFISGLLQRYELAPADLTLEITETVMMDTNPSTTRTIHELHAQGVKLAMDDFGTGYSSLGYLRNLPVSELKLDQSFVRDMNRDETVLALTNA
VIRIGESLNLTVVAEGVEDKRQYDLLKQQGCDVAQGYLFSRPMLAEIFEHWLKNFK----
>tr|R0G644|R0G644_9BURK Diguanylate cyclase/phosphodiesterase A protein OS=Herbaspirillum frisingense GSF30 GN=HFRIS_008656 PE=4 SV=1
-------------------------------------------------------------------------------------------LGVVELSPD
GLILAANRNYLKTMEYLAEDLVGKS---HSLLCDPEYANG----------EERFFSGRFPRRTRSGRTIWWEATYSPLLDK---AERVICIGNDVTYRVT
REKSDRLLSLGINETDNAVLITDAQNRIVFHNTGFTRMLGFQSQQVIGKQPRELFAHH------ERCHGELLQGHSFHTEELIHDFHEQPVWISAVVNPI
LDADGRLINAVCVMTDITNTKVSRARIHQLAFYDSLTGLPNRSLLLVQAGQAIAAAERNHSTVAVMFIDLDRFKQVNDSLGHQAGDELLRTVATRLQSQA
RRSDIVGRLSGDEFVVVLTQYDTLHLTEVVKRIQERLAMPCHINGTPLNPSASIGVAIFPDNGNDIETLLHRADIAMYQAKAVNRGRFSFFSEEMNSMAQ
ERLALEGALRDALRGGLFELHYQPQIRLREHTLHGVEALARWHDAQLGQISPGRFIPIAEECGLIGELGKWALEEACFQLADWRRRGIQVPCISVNLSAT
NFHDLDLPQFVTGLLRRYSLVPTDLTLEITETVLMDTNPSTNQTIAAVHALGIPLAMDDFGTGYSSLGYLRKLPVSELKLDQSFVRDMAKDDAVSALTNA
VIRIGESLKLTVVAEGVEDADQYQLLLSQGCDVAQGYYFSRPMAADELERWVRDFR----
>tr|J3HL46|J3HL46_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Herbaspirillum sp. YR522 GN=PMI40_03956 PE=4 SV=1
-------------------------------------------------------------------------------------------LGVVEFTAD
GVILGANSNYLKTMQYLAPELVGQP---HSLLCHDDYASS----------AERFFSGRFQRRARNGHTVWWEATYSPVLDQ---PLKVICIGADVTYRVT
REAKDRLLSLGINETDNAVIITDDQNRIVFHNIGFTRMLGFQAQDAVGKKPHELFANH------EACHGELLAGRSYHTEELIHDMHDQPLWMSAVVNPI
LDSEGKLINAVCVMTDITNTKVSRAKIHQLAFYDALTGLPNRALLLVQAGQAIAAAERSHSTVAVLFVDLDRFKQVNDSLGHQAGDELLRTIASRLQAQA
RRSDIVGRLSGDEFVVVLNQYDANHLTDVVKRIQEHLCEPCHINGTPLDPSASIGVAMFPANGSDIETLLHRADMAMYQAKAVNRGRFSFFSDEMNSMAQ
ERLALEGALRDALRGGDFVLHYQPQIHLGHGGLHGVEALARWPHPQLGQISPGRFIPIAEECGLIGELGKWALEEACFQLSDWRRRGIQVPSVSVNLSAT
NFHDLELPQFMAELLQRYALLPSDLCIEITETVLMDTNPSTNQTIAAVHDMGVPLAMDDFGTGYSSLGYLRKLPVGELKLDQSFVRDMVKDETVSALTNA
VIRIGESLKLTVVAEGVEELEQCRLLQQQGCDVAQGYYFSRPLTAEALEEWLRDFS----
>tr|A0A010RPI7|A0A010RPI7_PSEFL Diguanylate cyclase OS=Pseudomonas fluorescens HK44 GN=HK44_029390 PE=4 SV=1
-------------------------------------------------------------------------------------------MAIIEFTPD
GTVLRANRNYLKIFGYQEQQIRGLH---HRALCQADYANS----------SAQSISGQYLYVSAEGCLVWLEASYNPVFAQ---LLKIIQFASDVSTRVK
AERCDNLFTQIAERTHNSLVITNAKGVVVYINEAVTHLLGYQPEEVLGQPVALMLN------MV------LSSGHPYRGEELIYSKFQQPLLCALGVSPI
FDAQGALSHTLSVITDITDNKIARLQIRQLAFYDSLTSLPNRNLLLAQADQAIASAKHHNQSLAVLYIDLDRFKQVNDSLGRTAGDELLCVVTERLREQI
SDTDLLGRLSGDEFIVVLNSCTHVQAADTVKCLQELLSIPCQIAGITLTPSACIGISLYPDNGQDLETLLHHADLAMYHAKTNGRERFSFFSSEMNVLAQ
ERLALEAALREAVRAQCLYLHYQPQVDLKSGQIHGIEALARWHDPVLGHISPTRFIPLAEECGLIDEISHWALNESCRQLAEWRRQGLNIPTVSVNVSST
NFHNLDLARYLIETLEQHALLPGDLILEITESVMMDTNLSTMRNLHEVHALGIGLAMDDFGTGYSSLGYLRRIPLSALKLDKSFVNGMEHDVAAQALTHA
VIRIGDSLNLTVIAEGVETEAQRFLLDAQGCKVGQGYLFSQPLPPDLLADWLKTST----
>tr|U7DCZ2|U7DCZ2_PSEFL Diguanylate cyclase OS=Pseudomonas fluorescens NCIMB 11764 GN=B723_00220 PE=4 SV=1
------------------------------------------------------------------------------------------IDSVVVIDSQ
NRVILFNDAAESLWGNDRDQVLGQN---VRLLVPDMIRADHDSYIDANRRSGVGSSRDVLIERPDGDHRWGAMSISRVNAQ---LFYVA-VVKD----IT
RQHKEHLLSLVVDTTENAIIITDGQWSMVYANGGFTRMFGYDLDQVRGRTLDSVIAPD------AAINGQVMRGEVYHSQAVGYLREGRRVWCDVTIYPV
CDEHGNLVNTVSVMIDVTHSRMSRAHIRQLAFYDDLTGLPNRNLLNARADQAIAEASRDDTPLTVLFIDLDRFKQVNDSLGHPAGDEFLRMIARRLAKCR
RNVDIVSRLSGDEFVVVLPQCALAQAQVVIEHLRYELCAPCEIAGVTLKPSASIGVSLFPDDGRSMETLLHRADMAMYQAKTSGRGCVSFFSQGLDQLAR
ARLNLEAALREAIDQHLLHLVYQPQINLQGNDLYGVEALARWRHPQLGDISPGCFIPLAEECGLIVELGQWALREACRQLATWRREGLEVPAISVNLSPT
NFHNRGLPGILTGILAEQQLTTSDLTLEITENVLMDSNPDTLTTINEVHALGIRLAMDDFGTGYSSLSYLRRIPIQELKLDRSFVHDLEDDITSQALSEA
VIRIGESLKLRVVAEGIETLGQQRILQAQGYHVGQGYLISRPLSASGLRFWLEDRS----
>tr|A0A0A8BNP9|A0A0A8BNP9_9BURK Diguanylate cyclase OS=Pandoraea sputorum GN=NA29_13635 PE=4 SV=1
-------------------------------------------------------------------------------------------LGTLTLTPD
GLIADVNDKFLGVFGYTRDQLIGKP---HAILCNPADPTC------------RSHTDQVRRLRHDGSTVWLEATYNPIFDK---LTCVIKLAVDVTARVA
RQAADDLLSLGVDETDNAVLITDAQRRVCYVNAGFTRMLGYAASEVVGQSVHASST---EPMDESGCLVSAHDSRSCHCEVLVRTAQRQPLWVSVVTNPI
LDAQGKLVNAVVLFTDITQSKISRTRIRQLAFSDSLTGLPNRSMLGVLAAQAIASAAELNTRMAVIFIDLDRFKQINDSLGHQAGDVLLRTIAQRLRRSL
RGADIVARLSGDEFVAVLTECDPERLDIAIERMRTALTAPCQVDGVTLVPSGSFGISLYPNHGREFDILLQRADMAMYQAKMTSPGSVRFYHEDMNVHAQ
ERLELETAMRDALRLGKLQLFYQPQINLLDESVYGAEALTRWTHPQYGEVPPSRFIALAEECGLIGELGTWTLRESCRQLADWRRRDVGIGNVSVNLSPT
NFHDHDLPRTIAEALADHELPPSCLAIEITESVLMDHNPSTLRIIEEVHNLGVRLSMDDFGTGYSSLGYLRRLPVSELKLDRSFVHDIARDETVRALTNA
IISIGRNLHLTVVAEGVEDEAQRDLLVAQGYRVAQGYLFSPALSAGDLERWLERWS----
>tr|R7X1X0|R7X1X0_9BURK Diguanylate cyclase/phosphodiesterase A protein OS=Pandoraea sp. SD6-2 GN=C266_11475 PE=4 SV=1
-------------------------------------------------------------------------------------------LGMLTLTPD
GIIVDVNDKLLGVFGYARADLIGKP---HTMLCEPGDATC------------RSHTGQVRRRRHDGEAIWLEATYNPVFDK---LAFVIKLAVDVTARVE
RQAADDLLSLGVDETDNAVLITDAHGCVRYINAGFTRMLGYAASEVIGQSVHVPSGQFGAHVGEADCLVAASGGRSCHCEVLVRTAQHHPLWASVVTNPI
LDANGKLLNAVVLFTDITQSKISRTRIRQLAFSDSLTGLPNRSMLGVLAAQAIASADELNTRMAVIFIDLDRFKQINDSLGHQAGDVLLRTIAQRLRRSL
RGADIVARLSGDEFVAVLTECDPERLDIAIERMRSALTAPCQIDGVTLVPSGSFGISLYPNHGKAFDLLLQRADMAMYQAKMTSPGSARFYNEDMNIHAQ
ERLELETAMRDALRRGKLQLFYQPQINLLDESVYGAEALTRWTHPLHGEVSPSRFIALAEECGLIGELGMWTLRESCRQLADWRRRGVGIQNVSVNLSPT
NFHDHDLPRMIAETLADHGLPPSCLAIEITESVLMDHNPSTLRIIDEVHSIGVRLSLDDFGTGYSSLSYLRRLPVSELKLDRSFVHDITRDETVRALTSA
IISIGRNLHLTVVAEGVEDEAQRDLLVAQGYRVAQGYLFSPALSAGDLEHWLERWS----
>tr|L1LYV1|L1LYV1_PSEPU Diguanylate cyclase/phosphodiesterase OS=Pseudomonas putida CSV86 GN=CSV86_17602 PE=4 SV=1
-----------------------------------------------------------------------------------------------MIDSD
NRVILFNGAAEKLWGFHREEVLGNN---VSMLVPENIRSKHDGYVDSNRRTGVGTTRDVPIHKKDGSQRWGSMSISRVETQ---ILYTA-FVKD----VT
EQRKERLLSLVADQTDNAIFITDGSGRLVYLNKGFEKLFGYHLEEIADCQPAQLLVPD------VGLQRDLRGGRSCQVEELLQVKGGERIWCNVAINPV
AGANGELAHTVTVLTEITASKINRESIRQLAFYDSLTRLPNRSLLHANADHALIEARRTRTALAVLFIDLDRFKQINDSLGHPAGDELLKLVAQRLGANR
NSNDIVGRLSGDEFVVVLPDCDSERVNDTIEEIRQAISQPCRIAGSCFSPSASIGVSLYPRDGHDMSSLIHRADMAMYQAKSAGRGRFSFFSHELDELAQ
ERQALESALREAIAQGTLQLHYQPQVTIEDGRVYGVEALARWTHPTFGVVSPARFIPLAEECGLITELGHWVLREACRQLAAWRRRGLNIPAVSVNLSPS
NFHNLDLAAMIGSVLDQHGLVAADLTIELTENLLLDTNPGTMKVLHELNARGIRLAMDDFGTGYSSLSYLRKLPIQELKLDRSFVLDLEADETSRALSDA
VMRIGDSLHLKVVAEGVEQHGQYRILKDQGYHVVQGYLLSKPLPAHDLEAWMMKY-----
>tr|A0A071LVU6|A0A071LVU6_9ENTR Diguanylate cyclase OS=Mangrovibacter sp. MFB070 GN=DT73_10695 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------TWVPVADK---ITGVLALVRPATDQTR
HDFEQPQQFQVTEVIHTAVMVSDGDGHIRYVSKGFTQLLGWELNGLNGMNPVELLLGG------QAVIRELSAGEPLEGEYLIQDKNQHQHWVRLVCYPI
VNTQTRVSHQVWMVHSVTHSKIARQRISQLAFYDSLTGLPNRSLLQAKLDQEIEAAAHRNEAVAVLFIDLDRFKQINDSYSHQLGDDVLVQVAQRLQCAL
RVTDIAGRLSGDEFLVVMPQCDKDQVQEAVSRLQAVLHEPLELS-TPLSVTATIGIAMFPNDGKTVDELIQHADLAMSQAKSSGRGQWAFFSNDMGQTAQ
ERMRLESALRQAVKQGGLQLYYQPQITLSDNSIYGVEALARWYHPEFGMVPPSRFIPLAQECGLIAALGLWAMDAACAQLAEWQAQGIPVPAVSVNLSST
SFHDLSLPDTVARILEKHGLEPHHLTLELTESVLLDSNVNTVTCLNEVNALGVRLSMDDFGTGYSSLSYLRRLPFSELKLDRSFVADLENDEIACSLSKA
IMGIGESLRLTVVAEGVETCEQFNRLRDQGYPVVQGYLLARPMTPQALLAWLDERQ----
>tr|A0A010RMC8|A0A010RMC8_PSEFL Diguanylate cyclase OS=Pseudomonas fluorescens HK44 GN=HK44_008620 PE=4 SV=1
------------------------------------------------------------------------------------------VDAVVVIDDQ
NNVVFFNAAAEQFWGCPREEILGSN---VNRLVPHVIRPHHDGYVGANRETGVGVSREVHIARKDGEERWGAMSISKITLR---ILYAA-FLKDV----T
QTRLKDLLSMSVNITSSATCIVDADARLIYVNDGLVRLLGYSREEVIGRSPLMFFVSDIQ----QAVLEKVLRGEPCEASALISKRNGQRLWVHISSTPV
FDAQGKVDNIVIVLTDITRSKLARESIRRMAFYDALTGLPNRSFLLAQADRAIAEVAQEQAELAVLFVDLDRFKQVNDALGHASGDELLQVVAQRLRSVL
RESDIVGRLSGDEFVLVLPRMNATQVTTFLERLKMILSTPANIAGTSVGLSASIGISMFPDDGQYMENLLHCADIAMYQAKRTERGGFSFFLEEMNKIAQ
QRLILETALRATLAENGLHLDYQPQVDLRSGRLVGVEALARWEHPALGSISPARFIPLAEECGLINKLSQWVLQEACGQLAQWRRQGFVVPSMSINLSPI
NFHNLNLVGQIAEQLRRCKLQPADLCVEVTEGVLLCNSPGSEKTIQDLHALGVRLAIDDFGTGYSSLGYLRRLPISELKLDKSFVDDLEHDASCRALSES
VIGIGKGLSLHVVAEGIEHAAQRDILRAQGYEVGQGYFFSVPLSSGAFMQWMLSGP----
>tr|C4S5Q9|C4S5Q9_YERBE Phosphodiesterase OS=Yersinia bercovieri ATCC 43970 GN=yberc0001_20320 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------IYQPVPGP---VTHMVKIAKDITFLIE
QQEATQLLTQLTDRSDSAMFITANGQEAIYINQGFTKLFGYTPEQAMGQNMVDLLQSEHH----ALMDASANARQQLLPQELFYGKDRQPHWCSAVINSL
VDEQGKPSFSIGVLTDITLTKMSRKQIQHLAFYDSLTGLPNRSQFQVYAKQAIAMATEIGHTLAVLVINLDRFKQVNDSLGQGAGDELLALIAQRLRNDL
TKSDIIGRLSGDEYIIILAPCTMQQATLKVEKILSQLSQPCQIASVNIIPSASIGISLYPENGLDMDTLMNHANIAMHKAKNMGRGYFNFFSAEMNDLNQ
QRQDMEDALRHAFHIGSLELFYQPQVMLKDGHLYGVEALSRWNHPILGSIPPQRFIPIAEESGLINELALWAIETACQQLADWRLRGIDIPSVSVNLSPT
NFHNPGLPEMILHILQHYHLPPQDLTLEITEDILIENNPAIFATIEKIHRLGVRLSMDDFGTGYSSLSYLRRLDLDEIKLDKSFVHDLEYDETSRTLSEA
VIRIGESLQLSVIVEGVENEAQRTLLSRQGYQIGQGFLFSEALPAIKLEHWLEHRT----
>tr|A0A0B6HCK1|A0A0B6HCK1_YERRO Diguanylate cyclase domain protein OS=Yersinia rohdei GN=CH64_442 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------IYQPVPGT---LTRVVKIAKDITFLIE
QQKATQLLTQLTDRSDSAMFISANGQQAVYINQGFTKLFGYTPEQALGQNMVDLLQSEHP----ALMDSLPDTHQQLLPKELFYSKDRQPHWCSAVINSL
ANGQGEQSYSIGVLTDITMTKMSRKQIQQLAFYDPLTGLPNRSQFLVYAQQAITLATESGHSLAVLVINLDRFKQVNDSLGHAAGDELLAAIAQRLRHEL
SKNDLIGRLSGDEFII-LAPCTMQQATVKVEKLLSLLSQPCIIASVNIIPSASIGISLYPENGVGMDMLMNHADIAMHKAKKLGSGHFNFFSVEMNNINQ
QRQDMEDALRHAFHIGSLQLFYQPQVMLKDGHLYGVEALSRWIHPVLGDIPPNRFIPIAEECGLINELALWALNTACQQLADWRLRGVDIPSVSVNLSPS
NFHNPGLPDTISSILQHYNLPPQDLTLEITEDILIENNPAIFATIQKIHRLGVRLSMDDFGTGYSSLSYLRRLDLDEIKLDKSFVHDLEYDETSRTLSEA
VIRIGESLQLSVIVEGVENEAQRTLLSRQGYQIGQGFLFSEALPAIKLEKWIQHRV----
>tr|C4T5P6|C4T5P6_YERIN Phosphodiesterase OS=Yersinia intermedia ATCC 29909 GN=yinte0001_19080 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------IYQPVPGT---VTRMVKIAKDITFLIE
QQKATQLLTQLTDRSDSAMFIAANGQQAVYINQGFTKLFGYTPEQALGQNMVDLLQSAHP----RLMDSSPNSRQQLLPKELFYSKDQQPHWCSAIINSL
VDEQGKPSYSIGVLTDITLTKMSHKQIQRLAFYDSLTGLPNRTQFLIYAKQALALATETNYTLAVLVINLDRFKQVNDSLGLAAGDELLALIAQRLRSEM
SKDDIIGRLSGDEFIIILAPCTMQQATVKVEKMLSLLSQPCQIASVNIIPSASVGISLYPENGLEMDALMNHADIAMHKAKDMGRGHFNFFSAEMNTLNQ
QRQDMEDALRQAFHIGSLELFYQPQVMLKDGNIYGVEALSRWMHPILGNIPPQRFIPIAEECGLINELALWAIETACHQLADWRLRGIDVPSISVNLSPT
NFNNQGLPDMILHILQHYHLPPQDLTLEITEDILITNNQAIFAIIEKIHRLGVRLSMDDFGTGYSSLSYLRRLDLDEIKLDKSFVHDLEHDETSRTLSEA
VIRIGESLQLSVIVEGVENEAQRTLLSRQGYKIGQGFLFSEALSAGKLEQWLEQRT----
>tr|A0A0D5YWX4|A0A0D5YWX4_YERRU Diguanylate phosphodiesterase OS=Yersinia ruckeri GN=UGYR_01165 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------IYQPVPGK---TTHMVKIAKNITQQVA
LESSTHLLTELTDRSDSAMFIAGDGQKTLYINQGFTKLFGYTTQQALGQPIAALLQNGDT-----SLSATTYIHQALQPEELFYGQNHQPHWCSVTINSL
YDEQGHSSFTIGVLTDITLTKISRMKIQQLALYDALTGLPNRAQFLTHANQVIGDAQQCGYSLLVLVINIDHFKQVNDSMGQAAGDELLCIIAQRLRDDM
GKNDIVGRLAGDEFVLILAPCNIQQATVRVERLLSRLSQPCQISGMTIVPSAGIGISLYPENALEINSLLHHADMAKGKAKKRGRGQFQFFSAEMNEINM
QRQTLEDALRQAVHLNTLQLFYQPQVQLDDGQLYGVEALSRWYHPTLGEIPPQRFIPLAQECGLINELALWTINEACRQLADWRLRGINVPSISVNLSPT
NFHNLGLPEIIAHILQHYNLPPKHLTLEITEDILIDNNPTIFAIIGKIHQLGVRLSMDDFGTGYSSLSYLRRLELDEIKLDKSFVNDLEHDETSRALSEA
VIRIGESLQLAVVVEGVETEAQRQLLRLQGYQVGQGYLFSEPLQAVDFELWVKSHL----
>tr|W8UDS6|W8UDS6_YEREN Uncharacterized protein OS=Yersinia enterocolitica LC20 GN=LC20_02504 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------IYQPVPGT---VTRMVKIAKDITSLIE
QQKATQLLTQLTDRSDSAMFIAANGQQAVYINQGFTKLFGYTPAQALGQNMVDLLQSEHP----ALIAESPEARQRLLPKELFYSKDRQPHWCSAVINSL
SNAPGEQSYSIGVLTDITMTKMSRKQIQHLAFYDSLTGLPNRSQFLVYAKQAIAQAAEMHHSLAVLVINLDRFKQVNDSLGHAAGDELLAAIALRLRDSL
PKNDIIGRLSGDEFIIILSACSMQQTTVRVERMLSLLSQPCQIANMNIIPSASVGISLYPENGMEMDTLINHADIAMHKAKDKGRGHFSFFSVEMNILNQ
QHQDMEDALRHAFHIGSLELFYQPQVMLKDGHLYGVEALSRWNHPILGSIPPQRFIPIAEESGLINELALWAIETACRQLADWRLRGIDVPSVSVNLSPT
NFHNPGLADMILHILRQYHLPPQDLTLEITEDILIENNPTIFTTIEKVHRLGVRLSMDDFGTGYSSLSYLRRLDLDEIKLDKSFVHDLEYDETSRALSEA
VIRIGESLQLSVIVEGVENEAQRTLLSRQGYLVGQGFLFSAPLSAAKLEEWLENHM----
>tr|A0A0D9AYK8|A0A0D9AYK8_PSEFL Diguanylate cyclase OS=Pseudomonas fluorescens GN=UG46_14890 PE=4 SV=1
------------------------------------------------------------------------------------------VDSVVVIDNR
NKIILFNVAAQKLWGYSREEVLGRN---VDILVPANIRVHHDGYIEANRRTGVGTSRDVPIECKDGSRRWGAMSISKIEHE---ILYTA-FIKD----IT
QQHEEQLLSLVVDTTENAIIITDASWQIVFVNDGFNHMFGYTPQAVIGKTPIEVLAPY------GEIRGQVTQNNAYQGQDYGVHRDGSRVWCNVTTYSV
HDAHGHLTNTVSVLTDVTHTRMSRGHIRQLAFYDELTGLANRNLLHARAEQVIAQASRHKSNLAVVFIDLDRFKQVNDSLGHTAGDEFLRLVAHRLTEDR
RECDIVSRLSGDEFVLVLPQCTLAHAIDLIEKLRARLCFPCQICGITLKPSASIGVSLFPEDGHTMEVLLHRADMAMYQAKTRLRGSVCFFNDGLSQLTQ
GRLRLEAALREAMGQRSFHLVYQPQIDLSDSKLCGMEVLARWTHPQLGEISPLSFIPVAQECGLISELGLWVLSKACYQLSAWRKQGLQVPSVSVNMSPT
NFHNRDFSRLVARTLEQYGLQTKDLTLEITENVLMEINPDTLATIEEMHGLGVSLALDDFGTGYSSLGYLQRLPIQELKLDCSFVHDLQSDTTSQALSEA
VIRIGESLQMRVIAEGVETEVQQRILVNQGYKIAQGSLFSKPLAAKEMERWLEEHN----
>tr|J2P493|J2P493_9PSED PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Pseudomonas sp. GM17 GN=PMI20_00257 PE=4 SV=1
------------------------------------------------------------------------------------------NDAVVIIDER
NQVVFFNAAAERFWGCPRCEVLGSD---VSMLVPIPIRSRNDG------ETGIGTSRDVCITRKDGEERWGAMAISKITLR---ILYAA-FFKDV----T
QTRLKDLLSMSVNASSSATCIVDADGRLIYINDGLVRLLGYSREELLERSPQMFFVTDTP----ELQLESILSGQPHEACGLVSKRNGQRLWVQVCSAPV
FDAGGRIGNIVIVFTDITRSRLARQSIRHMALSDALTGLPNRSSLLAEANRSIAEVALEQGELAVLYVDLDRFKQVNEALGHASGDELLQLMAQRLRSVL
RESDIVGRLSSDEFVLVLPRMNATRVTTFLERLMPTLGAPADIAGTAVVPSASVGVSLYPSDGQDMESLLHCADIAMYQAKRTERGGFRFFLEEMDQLAQ
QRLQLETALRQALTSDGLHLVYQPQIDLHSNGLVGVEALARWEHPSLGTIPPARFIALAEECGLINYLSQWVLCEACEQLARWRRSGIRVPSISVNLSPI
NFHNLNLAALIARQLQRCGLQPADLCVEVTEGVFLCSNPTTEQTLQDLHTLGVRLAIDHFGAGYSSLGYLRRLPINELKLDQSFVEELEHDASCRALSEA
VIGIGKGLSLRVVAEGIEHPAQRDILQARGYDVGQGQLFSSPLPARAFGQWFVGWQ----
>tr|A0A069IDK9|A0A069IDK9_9BURK Intracellular signaling protein OS=Cupriavidus sp. SK-3 GN=CF70_001650 PE=4 SV=1
------------------------------------------------------------------------------------------SDAVFVLNAD
NRVIFLNAAAETLYGASRKQVFGMD---VDALVQKLPGIAARAH--------ALPLPAVQILRPDGERRFGFIAESSTRLT---L--RTLLLKV-A---G
SVEPSRLLSVIADEIDSAVLVVDADWHIVYANAGLTRMLGYTRGEMVGKTPRELLARE------ERLHAHRASPGGERHEALVYARDGSPLWVSATVRHL
VASGGDRHHGIVILTDITQQKAAAERIMQLDHYDSLTGLPNRSLLQMQASTLLPAARQAGTTLSVLFVDLDRFKHINDSLGHAGGDKLLREVAQRLIAHA
GESALVARLSGDEFALVLPDSDRARTIAAGKRILAALHQPLRIDHASIAPSASIGISMFPADGDALDYLLHCAEMAMYDAKAAGRNLFRFFSIEMNWAAQ
ERLALESALRDALLSEELHLNFQPQVFLRDGRLYGLEVLVRWHHPHFGVVSPDRFVPLAEDSGLIGALDRWVLEQSCAQLAAWRQQGLSVPTISVNISPA
SFRDPGLPAQVAETLARHGLPAQALVLEMTEGLLMEDDAGIAATVAAIHAQGVRLSMDDFGTGYSSLGYLRQLPVHQLKLDKSFVIDLESDAAARELASA
VIRIGDSLKLAVVAEGVENEAQRQFLLSQGCHMGQGYLFSRPLDAAAVARWITTPR----
>tr|K8Z179|K8Z179_XANCT Putative c-di-GMP phosphodiesterase or signal transduction protein OS=Xanthomonas translucens pv. graminis ART-Xtg29 GN=XTG29_0
------------------------------------------------------------------------------------------PDGVVVIDAN
ARILAFNQTAETLWGLPQAQVLGRP---LGELVPEEARAAFLA---------PGDSHELQLPSNDGVQRWVAVSAATVPQT---PLYVV-FVRDIS----
AERERDILSLALDRSDNAIVVCDAQLTILYVNPGFVHMFGHAADDVRGLLPSSVLHGA------RQIRERVVGGQGHQTDLLVYRKDGSPLWTTIVANPI
ADADGCIQHYVLSFTDITQSKMTKARVHQLAFYDALTDLPNRVMFSARAEQALAAAEYHAFPVAILFVDIDRFKRVNETQGHAAGDGLLRDIARRLGETL
SATDLIGRQAGDEFVLMLPQCGAEQAAGVAERLLLALAEPVVVGNVTLHPGASIGVAMFPDDGRDIETLLRHADLAMYRAKNEGGGSFRFFSADMNRMAQ
ERVALETALREALRRDQLQLHYQPQLHSQPPCLYGVEALLRWQHPHLGDISPARFVPMAEECGLIDELGHWALRQACRQMADWRLRGVQVPRVAVNLSAS
NFADAQLPARVAQMLSTHGLLPSDLALEMTESVMLSNAPAVLANLRQLQASGVRLSLDDFGTGYSSLSHLHQLPVNELKLDMSFVRDLEHSETARALTTS
VLRLGESLRLHTVAEGVETEAQRAFLSWLGCDVLQGFLFSPALPAIQLERWLDARQ----
>tr|D2UAD2|D2UAD2_XANAP Uncharacterized protein OS=Xanthomonas albilineans (strain GPE PC73 / CFBP 7063) GN=XALc_1353 PE=4 SV=1
------------------------------------------------------------------------------------------ADGIVVIDAQ
SRIVAFNHIAETLWNLPQAQALGRE---IGELIDEGIRADFLA------------DYRLLLQSGKDVQRWISISASPVPQG---PLQVL-QVRDIS----
AERERDLLSLALERSDSAIMLCDKDLHILYVNAGFSRVFGYDTKEILGKLPSGVLPGP------SQTRERMRAGFGHQVDLLVYRKDSTPLWITMVANPI
TEEDGSVQHYMLSFTDITHSKMTKERVHQLAFYDALTNLPNRVMFSARAEQALADAEYHGSPVAILFVDIDRFKRVNETQGHHAGDGLLRDIAQRLTEEM
GVTDLLSRQSGDEFVMMLPQCGAEQAAGTAERLLLALAEPVVVGHVTLHPSASIGVAMFPEDGDDIETLLRHADLAMYRAKDEGGGSFRYFSSDMNRMAQ
ERVALETALRDALHQNELQLHYQPQVFSQAPHLYGVEALLRWEHPNLGNISPARFVPMAEECGLIEELGQWALREACRQMADWRLRGIPVPRVAVNLSAN
NFAEPQLPARVEQMLSAYGLVADDLALEMTESVMLSNTAAVLDNLRQLQSSGVLLSLDDFGTGYSSLSHLHQLPINELKLDMSFVRDLEHSPTSRALTTS
VLRIGETLGMHTVAEGVETDAQRSLLAELGCGVLQGFLFSRALPASALEQWLQAQP----
>tr|N6Z844|N6Z844_9RHOO Diguanylate cyclase/phosphodiesterase OS=Thauera linaloolentis 47Lol = DSM 12138 GN=C666_09025 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------TYVPVIDR---VRQILKVATDVTERLR
QEQDQQRLSLVADASHAAVIISDAASAIVYVNAGFSRLLGWRQDEAIGASPILLLAPH------EAYRAELRAGRSIEREEIVIGKDGQRYWAKVISNPV
MDAGGRWQYTVTMLTDITSSKLSRQRIRELAFYDGLTGMPNRSLLYARADQEIATCSRLHKSMAVLFIDLDRFKQVNDSLGHPAGDELLRHVAAHLQQQL
RGTDFAGRLSGDEFVILLPGCSADEAAGAVERIQHVLAGPVSIA-TTVSVSASIGIAMFPSDGRDIETLLHRADMAMYQAKSCGRNESRFFSSEMNQLAQ
ERLRLENALREALQDNQLHLHYQPQIDLASGRLYGVEALARWTHPEFGVIPPVRFIPLAEECGLIGDLGRWVLREACRQLAAWRAAGLSVPAVSVNLSPT
SFHNLDLPGMISDTLARNALDSADLTVELTESVLLDTHPSTMKTLTEVHARGVRLSMDDFGTGYSSLSYLRRLPVSELKLDRSFVADLEHDEAARALSGA
ILGIGKSLHLTVVAEGVETPTQNEMLREQGYPVAQGYLFSQPLPPDEFARWLGTAV----
>tr|A0A014Q7R9|A0A014Q7R9_9BURK Diguanylate cyclase OS=Comamonas aquatica DA1877 GN=AX13_06235 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------TYTPVCDQ---LTQILKVATDVTQRHL
QEQAHQRLSLVADASDAAVIISDSQSRIVYVNGGFSRMFGWTQEEVLGQAPIALLAPQ------EQYRSELRGGKPVWSEEIVVGKQGQRYWAKVTSNPV
INDQGVWSCTVSVLTDITRSKMTRARIRQLAFYDGLTGLPNRSLLQANADQAMAAAARNDEQLAVLFIDLDRFKQVNDSMGHPAGDELLRVVAARLQKVL
GPGDIAGRLSGDEFVAVLPQCDAERVTNTIERLQEQLAEPLVLA-NALAISASIGIAMFPADGRDMETLLHRADMAMYQAKSSGRGRFSFFSSEMNRLAQ
ERLALENALRKALQGGELRLHYQPQVDLASGQLYGVEALARWTHPQLGEISPARFIPLAEECGLIADLGRWAVGEACRQLAAWRTQGLAVPAVSVNLSPS
SFHNLDLPRMIADTLDRHALAPKDLTLELTESILLDTNPSTMKTIEEVHAHGVRLSMDDFGTGYSSLSYLRRLPVSELKLDRSFVADLENDEAARALSSA
ILGIGQSLRLTVVAEGVETPVQNIMLREQGYPVAQGFLFARPLAPQDLERWLVARM----
>tr|L1LTZ2|L1LTZ2_PSEPU Diguanylate cyclase/phosphodiesterase OS=Pseudomonas putida CSV86 GN=CSV86_24904 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------TYTPVFDE---LTQILKIATDITPRLA
LERMQQMLSLVADASDTAVMISDSQRRIAYTNAGFGRMFGWQAEEIKGRSPMALLVPE------AEYYAELYAAGSMQREEIVVGKHGQRYWAKVVSNPV
FDAGGHLQHTVTLFTDITQAKMSRQRIRQLAYYDALTGLPNRSLLQAKADQAIASADRNNEQVAVLFIDLDRFKQVNDSLGHPAGDELLRQVAKRMRSEL
RASDIAGRLSGDEFVVILPQCDGDHAADAVERIQLLLSEPLTIA-THLAISASVGVAMYPADGCDVETLLHRADMAMYQAKSSGRGCFSFFSSELNKLAQ
ERLALENALREALQKDQLRLHYQPQVEMATGRLYGVEALARWTHPQLGEISPARFIPLAEECGLVADLGRWALREACRQLSEWRARGLAVPAVAVNLSPT
SFHNLDLPRMIADTLRSHDLAPADLTLELTENILLDTNPSTMKTIDEVHAQGVRLSMDDFGTGYSSLSYLRRLPVSELKLDRSFVADIETDEAARALSNA
ILGIGRSLHLTVVAEGIETESQSVWLEKQGYPVAQGYLFSPPLAPDALARWLEERV----
>tr|A0A0E3C0J7|A0A0E3C0J7_COMTE Diguanylate cyclase OS=Comamonas testosteroni GN=P245_14750 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------TYSPVMDR---VMHILKIATDVTQRRA
REQAQQRLSLVADASDTAVVISDGSSRIVHVNGGFTRMFGWHSEEVAGRMPIALLAPQ------DLYRSELRAGQPVGREEIVVGKNGQRYWAKVISNPI
LDADGHWQYTVSMLTDITRSKMSRARIRQLAFYDGLTGLPNRSLLQAKADQAIASAAGNDEQLAVLFIDLDRFKQVNDSLGHPVGDELLRNVATRLQRVL
RSSDIAGRLSGDEFVAVLPQCDAEHVANTIERLQELLSEPLNIA-TSLTISASVGIAMFPMDGRDMETLVHRADMAMYQAKSKGRGRFCFFSSEMNRLAQ
ERLALETALRKALKSGGLRLHYQPQIEMATGRLYGVEALARWTHAELGEISPARFIPLAEECGLIADLGSWALEEACRQLSQWRARGMEVPAVSVNLSPS
SFHNLDLPRMIADTLDRNDLVPQDLTLELTESILLDTNPSTMKTIDEVHAHGVRLSMDDFGTGYSSLSYLRRLPVSELKLDRSFVADLEHDEAARALSSA
ILGIGKSLHLTVVAEGVETPTQSVMLCEQGYPVAQGFLFARPLAPKEFEHWLAANP----
>tr|A0A0B2NSA0|A0A0B2NSA0_9XANT C-di-GMP phosphodiesterase OS=Xanthomonas vesicatoria GN=OR60_06175 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------MRAPPSDPTDL-----------AGTRTGTDAWATAD----LVGDPSSIAAMDS-IPGPVTAGMAKP------
GEHPEDLLAEALDGSSSAILICDLQSRLLYANDGFQRMFGYTEAELVGQRPSDVLTRAQSQSEVSRIRDRADALQQTRADLLVYRKDGSPLWISLNFNPI
YDARHNPSHYVAVLTDITDTKMTRQRVHQLAFYDALTGLPNRIMFSARAEQALTQVEYAAEPAALMFINIDRFKLINDSQGHSAGDGLLRDVALRIGEQL
AATAMLARVAGDEFALALPQCSAEQATAAAERLLGSISSPLPVGHMTVHPSASIGVAMFPEDGRDINILLRHADLAMNRAKKEGGGRFRFFSSDMNRMAQ
ERVALEAELRQAIGRDQLQLHYQPQLHSAAPHLYGVEALLRWNHPQLGAISPARFLPVAEEQGMMPQLNAWVLRRACEQVADWRNRGVPVTRVSVNLSAS
GFESPRMLPDLLRLIADTGVQACDLTLELTESVMLSGQPGVLENLHAIREAGISLSLDDFGTGYSSLSHLHRLPIDELKLDMSFVRDIEHSEDARALTTS
VLRIGEHLRKHVVAEGVENEAQRLFLADLGCEVLQGYLFSRPLPAPALEAWLSAQP----
>tr|A0A081YBP1|A0A081YBP1_9PSED Diguanylate cyclase OS=Pseudomonas sp. AAC GN=FG99_14075 PE=4 SV=1
--------------------------------------------------------------------------------------------VV--LDEH
NRVLLFNAAAERLWGYSREAVLGQD---VGLLLPREVRPRLDARLDTEGIVG---RSEVPMRCRDGSRLWGSMSISHIEFK---RL-LAAFVKDCTL---
-QRRQRVLSLAANETDNAVIVTGREGRILYVNAGFSRMFGWNAEQAQGRYPSELLQ------VP------QAGAGLFRSEELVRDLIGRPLWCSVVANPI
LDARGQPVNSVMLLTDITHTKLARAHIRQLAFYDTLTGLPNRSLLLAEAEQAMTRIENDEAEMAVLFIDLDRFKQINDSLGHPAGDELLRLVAARLQEVV
REQGLVGRLSGDEFVVVLPYCGGLLASQIAERILARLALAHRVGGVSLITLASIGISLFPSNGRDMETLLHRADIAMYQAKNGGRGSYRFFSEEMNQRAQ
ERLALESALREAVQRQALSLHYQPQVRLDDGRVHAVEALARWRHPQLGAVAPNRFIPLAEECGIIGELSQWVLREACRQLADWRRRGIHVPAVAVNLSPA
DFRDPDLPVRLQDLLQRNGLAGTDLVVEITEGMLLDNHPATLDILRAVHGLGVRLSMDDFGTGYSSLGYLHRLPISELKLDRSFVAELNAGAAAQALTDA
VMNIGRSLELMVVAEGVEDEAQLELLRQQGYPVAQGYLFSRPLPAAALEEWLVRRG----
>tr|H1XI88|H1XI88_9XANT Sensory box protein OS=Xanthomonas axonopodis pv. punicae str. LMG 859 GN=pdeA PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------MAAHPSHPTNQ-----------PPAGAGVDAAMDG-------MPLTAEPIHAV-RPGPVTAGMAKA------
GEQPEQLLAEALDGSSSAILICDLQSRLLYANDGFQRMFGYTEAELVGLRPSDVLTRAQSQSEVARVRDRADALQHTRADLLVYRKDGTPLWISLNFNPI
YDANHAPSHYVAVLTDITDTKMIRQRVHQLAFYDTLTGLPNRIMFSARAEQALTQAEYAGEPAALMFINIDRFKLINDSQGHAAGDGLLRDIALRVNDQV
AATAMLARLSGDEFALALPQCSAEQASAAAERLLVSIASPLPVGHMTVHSSASIGVAMFPENGQDINILLRHADLAMNRAKKEGGGRFRFFSSDMNRMAQ
ERVALEAELRQAIDRDQLQLHYQPQMHSAAPHLYGVEALLRWNHPQLGAVSPARFLPVAEEQGMMPQINAWVLRSACQQVADWRQRGVPVARVSVNLSAS
GFESPRMLSDLLRLIAETGVQPSDLTLELTESVMLSGQPGVLENLHAIREAGISLSLDDFGTGYSSLSHLHRLPIDELKLDMSFVRDIEHSEDARALTTS
VLRIGEHLRKHVVAEGVENEAQRLFLADLGCEVLQGYLFSRPLPAPALEAWLDAQP----
>tr|E8TW46|E8TW46_ALIDB Diguanylate cyclase OS=Alicycliphilus denitrificans (strain DSM 18852 / JCM 14587 / BC) GN=Alide_4117 PE=4 SV=1
------------------------------------------------------------------------------------------VDAVVVIDEH
NRVVLFNAAAETLWGWPRAEVLGRN---VGMLVPPGIREAHDGYVNTNRITGVGTSRDVPVERRNGTRLWASMSISRVVIR---VLYTA-FLKDVT----
AQRAQQQLSLVADRSGSGMVVADADRRITYVNAGFTRLLGFAGAHALGRRLPELARGP------DALRACAEAGQEMQTQLLLYTSDGRPLWASVMMNPV
RGAAGELEHIVFVLTDITHTKMERAHIHQLAYYDALTGLANRSMLRTQAERRLHEARRSGAPLALLFIDLDRFKQVNDTQGHPAGDALLSAVATRLQDSA
RAGDVAARMGGDEFVLVLPQCGASQAAAVAERLLAAVAQPVEAEGAVLYPSASLGIAMYPEDGTDADSLLRCADMAMYQAKSAGGQCYHFYSAEMNDQAQ
ERSRLESDLRATLRSGGLALHYQPQMH---GQLHGVEALLRWTHPQHGPIPPPRVVETAGECGLLDALTQWVLQEACRQMADWRRRGVAVPRVSVNLDAD
SFLDPALPDLLAGTLTAHGLQPADLTVEITEAVMLTSDPAVLATARAVRERGIALSLDDFGTGYSSLSALHRLPIGEIKLDASFVQDIETSATVRSLASA
VLHIARGLDLSVVAEGVETPAQRQFLTEQGCAVLQGYLLSRPMPADALESLLQGGA----
>tr|F0BZM0|F0BZM0_9XANT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Xanthomonas gardneri ATCC 19865 GN=XGA_0024 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------MSALPPSPTDQ-----------PGSVAAADST---------VD----SATELI-KAGPVTAGMVKP------
DERPDALLAEALDGSSSAILICDLQSHLLYANDGFQRMFGYTEAELVGKRPSDVLTRAQSKNEVARIRERADSLQQTQADLLVYRKDGTPLWISLNFNPI
YDARHNPSHYVAVLTDITDTKMIRQRVHQLAFYDALTGLPNRIMFSARAEQALTQAEYASEPAALMFINIDRFKLINESQGHAAGDGLLRDIALRIGEQL
TATAMLARLAGDEFALALPQCSAEQASAAAERLLCTIAVPLAVGHMTVHPSASVGVAMFPEDGRDINILLRHADLAMNRAKKEGGGRFRFFSSDMNRMAQ
ERVALEAELRQAIGRDQLQLHYQPQLHSAAPHLYGVEALLRWNHPQLGAVSPARFLPVAEEQGMMPQLNDWVLRRACQQVADWRQRGVPVARVSVNLSAS
SFESPRMLSDLLRLIADMGVLPSDLTLEMTESVMLSGQPGVLENLHAIREAGISLSLDDFGTGYSSLSHLHRLPIDELKLDMSFVRDIEHSEDARALTTS
VLRIGEHLRKHVVAEGVENEAQRLFLADLGCEVLQGYLFSRPLPAAALEAWLGAQP----
>tr|R0FUL6|R0FUL6_9XANT C-di-GMP phosphodiesterase A OS=Xanthomonas fragariae LMG 25863 GN=O1K_08127 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------MR----------------------SAIAADVLADSA----AA---TTGPIKTI-EPGPVTAGVAKA------
GEQPQELLAEALDGSSSAILICDLQSRLLFANDGFQRMFGYTEAELVGQIPSHVLTRAQSHSEVARIRERADALQQSQADLLVYRKDGTPLWISLNFNPI
YDADQNPSHYVTVLTDITDTKVIRQRVHQLAFYDTLTGLPNRLMFSARAEQALTQAEYAGEPAALMFINIDRFKLINDSQGHSAGDGLLRDIALRIGDQL
SATAMLARLAGDEFALALPQCSAEQAGAVAERLLGTIAGPLPVGHMTVHPSASIGVAMFPEDGREINILLRHADLAMNRAKKEGGGRFRFFSSDMNRMAQ
ERVALEAELRQAIGRNQLQLHYQPQLLSAAPHLYGVEALLRWNHPQLGTISPARFLPVAEEQGMMPQLNDWVLRSACRQIADWRHRGVPVARVSVNLSAS
SFESPRMLVDLLRLISDMGVLPSDLTLEMTESVMLSGQPDVLENLHAIREAGISLSLDDFGTGYSSLSHLHRLPIDELKLDMSFVRDIEHSEDARALITS
VLRIGAHLRKHVVAEGVENEAQRLFLADLGCEVLQGYLFSRPLPAAALEAWLSAQP----
>tr|S6IGA6|S6IGA6_9PSED Diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. CF161 GN=CF161_31689 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------TYTVILDN---VQRVVKVATDISLRHQ
RESELARLSLVAGATDSGVLIVGADWRIQYVNSGFSRMFGWQQEDLTERSPIELLAAN------DYVRLELLAGRSVRREEIVVGKSGQRYWINVVANPV
MGEDGDLVSVVSVLTDITQSKMARARIRQLAFYDALTGLPNRSLLQARADQAISAARRDSSQLAVLFVDLDRFKKVNDSLGHPAGDELLRIVAGRLERES
RESDIVGRLSGDEFVLILPHCDSTQVAAQAEQLLLALGAPCLVD-VSVACSASIGISVFPGDGRDMETLLRRADMAMYQAKSAGRGQLSFFSHELNLLAQ
ERLALETALREALQNNGLRLHYQPQIDLASGQLCGVEALARWTHPQLGEISPARFIPLAEECGLIADLGRWVLAQACRQLSDWRRRALAIPSVSINLSPT
SFHNLDLPRMIADTLDHHGLVPRDLTLEITEGVLLDTNPSTLKTIDEVHAQGVRLSMDDFGTGYSSLSYLRRLPLSELKLDRSFVSDLEDDSAARALSAA
IMGIGKSLNLTVVAEGVETAGQCLVLKDQGYSVAQGYLFARPLAPESLEAWLSAAM----
>tr|A0A052I8L0|A0A052I8L0_9BORD Diguanylate cyclase (GGDEF) domain protein OS=Bordetella hinzii 8-296-03 GN=L540_2721 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SYTPVRGA---ILHILKAATDISAQVR
REQAQKQLTLAADATDTAVIMADSEARFVYANAGFTRMFGWTAQEVMGKNTIDLLTPQ------HVRRKRLIRGIASQREEIVVGKQGQRYWAKIITNPM
FDGQGRLTHIVTMFTDITRAKMARQRIRQLAFYDGLTGIANRSLLLAKADQAIASASRNKDPLAVLFIDLDRFKQVNDSLGHVAGDELLRAAADRIRAKL
RPTDLLGRLSGDEFVVVLPQADADRAADAVERLQAELALPLQLA-TDLSISACVGVAMFPADGSDMETLLQRADLAMYQAKSGGRGRFSFFSGEMNRLAQ
ERLALETDLRHALKKGMLRLNYQPQIELGTGRLYGVEALARWTHPTLGDIPPSRFIPLAEECGLIADLGLWAVRAACRQLSAWRAKGLTVPAVSVNLSPT
SFHNLDLPRTIADILRKNALAPADLTLELTESILLDTNPSTMQTIAQVHAQGVRLSMDDFGTGYSSLSYLRRLPVSELKLDRSFVADLGHDAAARALSAA
ILGIGKSLDLTVVAEGVETSAQNLMLHEQGYPVAQGYLFSRPLPPAELEAWFLHEH----
>tr|F7T176|F7T176_9BURK C-di-GMP phosphodiesterase A OS=Achromobacter insuavis AXX-A GN=AXXA_13424 PE=4 SV=1
-------------------------------------------------------------------------------------------LLLFDFDAA
GSLLNANDNFLAALNYTRADVAGLR---HDLLCDS--------MDEGKGIASEFFSGTCRYRKQSGASVWIEATYLPMRDE---VRRIAVISRKSIA---
-DAERQLLLLGINETGNAVAVSGRDGRIVYVNDGFQRMLGFSRADALEQELGELLA------GT------IACREGYHKDVLVYDRSGKPLWVSVMANSV
FDERGSLVNIVDVLTDITPTKVARARIRQLAFYDELTGLPNRNLLLAQAEQAIARAEPERKRVAVLFLDLDRFKQVNDTLGHPIGDALLRDIAQRLRRLA
RATDIVGRLSGDEFVMLMPDFEHGRLTAAAEHILVALAQPFVVGGITLNPSVSIGISVFPENGRDMDTLLRHADMAMYQAKTAGRNRISFFSAEMNRQAQ
ERLALEAALRDALEGRALRLHYQPQVGLKNGSLYGVEALARWRHPTLGDISPARFVPLAEECGLIGDLGDWAVREACSQLAIWRNNGLRVPSVSVNLSAT
NFHNLNLPRMIAATLAEFGLAASDLMLEITEGVVLDATAGTLRTIAELHRLGVRLSMDDFGTGYSSLGHLRRLIVDELKLDRSFVQGLENDDAARALTSA
VIRIGESLSLPVVAEGIENEEQRRFLIEQGCAAGQGFLFSPPLPANDLEDWLRARG----
>tr|U2ZPI3|U2ZPI3_PSEAC Oxygen sensor protein DosP OS=Pseudomonas alcaligenes NBRC 14159 GN=dosP PE=4 SV=1
------------------------------------------------------------------------------------------VDSVVVIDSR
NQVILFNRSAEHLWGLPREKVIGHN---VSILVPPDIRADHDGYIEANRRTGVGSSRTLHVQRPDGSRRWASMSISKIEAE---VLYTA-FIKD----IT
EQHQQDLVSLVVDRTDSAIMIIDGEWRTLYVNDGFNRLLGYSREHLDSHTPLRLLAPY------AAIRAQLAAGQPYNSDELAYCADGQRIWCHVAINPV
LDADGVMSNAVVVLTDITQSKMSRTQIRQLAFYDSLTQLPNRSLLHARADQALAEAARNRTPLSVLFVDLDRFKQVNDSLGHPAGDELLRLIAGRLCENR
RSSDIVGRLSGDEFVVVLPQCGSQQIAEMLEQLRHTLSQSCEIAGSTIRPSASIGIAMYPADGHDMGTLVHRADMAMYQAKSSGRGRYSFFSHELNQLAQ
ERLALESALRDALEQNQLSLHYQPQVRMSDGMLYGVEALARWHHPQFGDISPARFIPLAEECGLINQLGLWAVREACSQLAQWRRQGLAIPSVSVNLSPT
NFHNLDLPGMIAQTLEQNRLQPSDLTLEITESVLLDTNPSTLKTLDEVHNQGIRLSMDDFGTGYSSLSYLRRLPIQELKLDRSFVLDLEQDTTNQALSEA
VIRLGESLHLTVVAEGVENHGQQRILKQQRYHVGQGYLFSRPLSAADLESWLRSVS----
>tr|A0A095UXD7|A0A095UXD7_9BURK Diguanylate cyclase OS=Achromobacter sp. RTa GN=JL37_14125 PE=4 SV=1
-------------------------------------------------------------------------------------------LLLFDFDAA
GSLVRANENFLAAVAYPREEALALR---HDMLCDS--------LDEGKGIVGRHFSGTCRYRRKGGSFLWIEATYVPILDE---VTRITVISRRSIA---
-DAERQLLLLGINETGNAVAVSGQDGRIVYVNDGFKRMLGFSRGDAVDQELGELLS------GG------IACREGYHKDVLVYDRAGRPLWVSVMANSV
FDDRGALVNIVDVLTDITPTKVARARIRQLAFYDELTGLPNRNLLLAQAEQAIARAEPERKRVAVLFLDLDRFKQVNDTLGHPIGDALLRDVAQRLRRLA
RASDIVGRLSGDEFVMLMPDFEHGRLTAAAEHVLVALAQPFSVGGITLNPSVSIGISVFPENGRDMDTLLRHADMAMYQAKTAGRNRISFFSAEMNRQAQ
ERLALEAALRDALEEKALRLHYQPQVGLENGALYGVEALARWRHPTLGDISPARFVPLAEECGLIGDLGDWALREACSQLAVWRGKGLRVPSVSVNLSAT
NFHNLNLPRMIEAILSEFDLAPADLMLEITEGVVLDATAGTLRTIAELHRLGVRLSMDDFGTGYSSLGHLRRLIVDELKLDRSFVQGLESDDAARALTSA
VIRIGESLSLPVVAEGVENEEQRRFLIEQGCAAGQGFLFSPPLPAEDLEEWLRGRP----
>tr|A0A014MUF9|A0A014MUF9_9BURK Diguanylate cyclase OS=Comamonas aquatica DA1877 GN=AX13_00100 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------TYSPVLDQ---VVEILKIATDITARRT
QEQAQKRLSLIADATDTAVIMSDASSRIVHVNGGFSRLFGWHAEEILGQDPITLLSPK------QTYRAQLRGGLPVEREEIVVTKTGRRYWIKVVSNPI
LDDAGQLLFTVSMLTDITRAKMARSRIRQLAFYDGLTGLPNRSLLQAQANQAITLAARDKQALAVLFIDLDRFKPVNDSMGHPAGDELLCNVAACLLQAL
GPSDMAGRLSGDEFVMVLSQTDAEQATSTIERLQEQLANSLVVA-KPLAVSASIGIAMFPEDGRDMDTLLQRADMAMYQAKNAGRGLFSFFSDEMNRLAQ
ERRTLETALRDALKNQELHLHYQPQIELASGQLYGVEALARWTHPELGPISPARFIPLAEECGLIADIGRWALGEACRQLAQWRTQGLRVPSVSVNLSPS
SFHDLDLPDMVAQTLQRNALLPQDLTLELTESILLDTNPSTMKTIEAVHAHGVRLSMDDFGTGYSSLSYLRRLPVSELKLDRSFVADLEHNESARALSNA
ILGIGQSLHLTVVAEGVETLAQRSMLGMQGYPVAQGFLFAHPLAPSELTEWLLQQG----
>tr|Q13IZ7|Q13IZ7_BURXL Putative diguanylate cyclase(GGDEF)/ phosphodiesterase(EAL) with PAS/PAC and GAF sensors OS=Burkholderia xenovorans (strain LB4
------------------------------------------------------------------------------------------PDAVVLVDED
GAIGFFNPAAEALWGLTAAAVLGAD---AGMLLPRGIQPAGHGVQTGN----DGPGLALQIERNDGVMRRGQMSIHGFEVR----RFRAAFIRDI----T
DQHRQCQLLRVVNGSDNAIIVASLDGSISFINSGVTRMLGYAAAEVQGLRLVEPFAGVHTM---SAAREPSTPDHPFRQDLLVYTKGGRPLWVNVGITVI
TDNAGAPVNLLAVLTDITLTRMARMRIHQLAFHDTLTGLPNRNMFETQAQQLLNDARRTERELALVFIDLDHFKRVNDTRGHATGDEVLCETGRRFKSVL
RDGDLLGRLAGDEFVAILPHCGVHQATGIVERLLAATAPPVVVAGAPIHASASIGIAMYPADGEHVPTLLRQADIAMYHAKARGRGHFCFFREEMSRNIQ
EQAMLEADLRVALKHDLLDLWYQPQFDAANGHLSGVEALLRWNHATLGSVPPVRFVVLAEECGLIGELGKWVTQRACRQLADWRARGVEIPRVSINLSAS
DFRDSTLAERVARTLLAHGLQPHDLTLEMTESVMLGDEPGVLSMIDELHRLGIQLSLDDFGTGYSSLGYLHRLPLDELKLDRSFVRDLDHSDSARALTST
VLRIGESLNIKVVAEGVETDTQRQFLVEHGCPVLQGYLLARPMAPHLLEEWLRAAH----
>tr|A0A077LD62|A0A077LD62_9PSED Diguanylate cyclase/phosphodiesterase OS=Pseudomonas sp. StFLB209 GN=PSCI_1059 PE=4 SV=1
------------------------------------------------------------------------------------------GNSVVVSDAD
NCVVLFNQAAELLWGLKRHEVIGQD---AKCLLPQPVH----GYYQQQENG-DGELLILRIPHRDGGQHWGSLSISRVASQ---TYFVT-SIKD----IT
RQHEECLLSLVTDHSDNAIIITDENWRISYVNAGFERMSGYRFDQVCGQHPAAMLAPY------LAARQTLSSGQSIKTDQLTCIQNGERLWCSVVVNPI
LDNQGRLLNAVGILTDITSTKMSRAHISQLAFYDSLTELPNRSLLLANTEQALHAAQRNKTSLAVLFIDVDRFKQVNDSFGHPAGDELLQVIARRLQENR
SQKDIVGRLSGDEFVVVLPDCDNQRVTELVEQMKLTIAQPCQVGNSRVSPSVSIGVSMFPEDGHDMGTLIHRADMAMYQAKNAGRGRFSFFCHELNQLAQ
ERQAMENALQQALQDGALELHYQPQINIADGRLYGVEALARWHHPHWGQVSPARFIPLAEECGLIVELGLWGIREACRQLAAWRGKGAKLPAISVNLSPT
NFHDLALPAMLTQLLDEHQLSPGDLTLELTENILMDTNPSTLKVLNDVHALGIRLAMDDFGTGYSSLSYLRQLPIQELKLDRSFVMDLENDATARTLSDA
VIHIGNSLNLTVVAEGIETEGQHEILRQQGYHVAQGYLFSRPLSAPDLERWLLAR-----
>tr|C4SP11|C4SP11_YERFR Diguanylate cyclase domain protein OS=Yersinia frederiksenii ATCC 33641 GN=DJ58_3229 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------IYQPVPGS---LTRMVKIAKDITFLIE
QQKTTQLLTQLTDRSDSAMFIAANGQQAVYINQGFTKLFGYTPEQALGQNMVDLLQSAHP----ALIDSATDVRQQLLPKELFYSKDRQPHWCSAVINSL
VNEQGEQSYSIGVLTDITLTKMSRKQIQHLAFYDSLTGLPNRSQFLIYAKKTIALAAEVGHSLAVLVINLDRFKQVNDSLGHAAGDELLASIAQRLRNEL
PKNDIIGRLSGDEFIIILSSCTMQQATVKVEKMLSLLSQPCMIANVNIIPSASIGISLYPENGEEMDTLMNHADIAMHKAKNRGHGHFNFFSVEMNDINQ
QRQDMEDALRHAFHIGSLELFYQPQVMLKDGHLYGVEALSRWVHPILGNIPPQRFIPIAEESGLINELALWAIETACEQLADWRLRGIDVPSVSVNLSPT
NFHNPGLADMILHILQHYHLPPQDLTLEITEDILIENNPAIFTTIEKIHRLGVRLSMDDFGTGYSSLSYLRRLDLDEIKLDKSFVHDLEHDETSRTLSEA
VIRIGESLQLSVIVEGVENEAQRTLLSRQGYQIGQGFLFSEALPAIKLEKWLEHRL----
>tr|V5PQJ1|V5PQJ1_9BURK Uncharacterized protein OS=Pandoraea pnomenusa 3kgm GN=U875_09285 PE=4 SV=1
-------------------------------------------------------------------------------------------LGMLTLTPD
GIIVGVNDKLLGEFGYTRDELLGQP---HTLLCAPDDPTC------------RSHTGQVCRRRRDGQPIWLEATYNPVFDE---LAFVIKLTVDVTARVA
RQAADDLLSLGVDETDNAVLITDAQSTVCYVNAGFTRMFGYAAEDVVGQSVGNS---FGASTDEVGCMLSARDGRSCHCEVLVRTAQHQPLWVSMVTNRI
LDANGELAHSVVLFTDITQSKISRTRIRQLAFSDSLTGLPNRSMLNVLAAQAIASATELSTRMAVIFIDLDRFKQVNDSLGHQAGDVLLRTIAQRLRRAL
RGADIVARLSGDEFVAVLTECDPERLDIAIERMRSALNAPCQVDGVTLAPSGSFGISLYPSHGREFDILLQRADMAMYQAKMTSPGSVRFFSEDMNIHAQ
ERLELETAMREALRRGTLQLFYQPQINLLDETVYGAEALTRWPHPQYGDVPPSRFIALAEECGLIGELGTWTLRESCRQLADWRRRGVGIANVSVNLSPT
NFHDHELPRTIAQALADHGLPPSCLAIEITESVLMDHNPSTLRIIDEVHAMGVRMSMDDFGTGYSSLGYLRRLPVSELKLDRSFVHDITRDETVRALTSA
IIGIGHSLHLTVVAEGVEDETQRDVLVAQGYRVGQGYLFSPALSAGDLERWLERWS----
>tr|A0A0B6LIR3|A0A0B6LIR3_YERAL Diguanylate cyclase domain protein OS=Yersinia aldovae 670-83 GN=AT01_551 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------IYQPVRGS---VNRMVKIAKDITLLIE
QQKATQLLTQLTDRSDSAMFIAANGQQAVYINQGFTQLFGYTPEQALGQNMVGLLQSAHP----VLNDSSPNAQQQLLPKELFYSKDKQPHWCSAVINSL
VDEQGKSSYSIGVLTDITLTKMSRKQIQHLAFYDSLTGLPNRNQFQVYAKQAIVQAAERGHTLAVLVINLDRFKQVNDSLGHAAGDELLAAIAQRLRNDV
SKGDTLGRLSGDEFIIILAPSTMQQATLKVEKMLSLLSQPCQIADMNIIPSASVGISLYPENGSDLDTLMIHADIAMHKAKNMGYGHFNFFSAEMNNLNQ
QRQDMEDALRNAFHIGSLELFYQPQVMLKDGHLYGVEALSRWVHPILGNILPQRFIPLAEECGLINELALWAIETACRQLADWRLRGIEVPSISVNLSPT
NFHNPGLPEMILHILQRNHLPPQDLTLEITEDILIENNAAIFVTIEKIHRMGVRLSMDDFGTGYSSLSYLRRLDLDEIKLDKSFVHDLEHDETSRTLSEA
VIRIGESLQLSVIVEGVENEAQRTLLSRQGYQIGQGFLFSEALPAIKLEQWLEHRT----
>tr|A0A097FQJ0|A0A097FQJ0_9BORD Diguanylate cyclase domain protein OS=Bordetella holmesii 44057 GN=D558_0123 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------TYTPVYDN---IQHILKAATDITEQVR
QEQAQYRLTLAADASDTAVIMADNDTRFIYANAGFTRMFGWSAEEVIGRHTVELLTPH------QARHKQLLKGVSSQLEEIVVGKQGQRYWAKIITNPI
FGSQGEITHIVTMFTDITHAKLARERIRQLAFYDDLTGIPNRNLLLAKAEQAIAAAARNRTPLAVLFIDLDRFKQINDTLGHVAGDELLRAAAERMRAKF
RPNDLMGRLSGDDFVVVLSNTGTDRAADVVEHLQGELARPLRLA-TDLSVSACVGLALFPADGRDMETLLQRADLAMHEAKAAGRGGFSFFSTEMNRLAQ
ERLALENDLRHALKKGLLRLDYQPQIALASGTLYGVEALARWTHPTLGDIPPSRFIPLAEECGLIADLGLWAVRSACRQLAGWRSKGLTVPAVSVNLSPT
SFHNPELPRLICETLRRHGLAPADLTLELTESILLDTHPSTMQTISQVHALGIRLSMDDFGTGYSSLSYLRRLPVSELKLDRSFVADLDHDAAASALSAA
ILGIGESLHLTVVAEGVETSRQNALLHQQGYPVAQGHLFSRPLPASELEAWFARDL----
>tr|B8GMU1|B8GMU1_THISH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) GN=Tgr7_2681 P
------------------------------------------------------------------------------------------VDGVVLINRL
GIIREVNPAVTRIFGYERKEMLGAN---VSLLVPSPDRERHDQYLRNYLQTGIGVGRTVHGQRKDGSLFPMELAVSEVKAG---EHLFAGIVRDISERHQ
FHQTLALFRRAMDSAYNGIADVDAEGERISYNAAFAQITGIPAVDLLGRSLTLLACEGEDQTCT-AMVSQMRT-GSMRRTLRCQRPDGSLFWNDVTLSPI
FNERGEISQCIAVLADATALKEYQNRLRHLANFDPVTGLPNRTLFKDRLQHALANATRNQRLVALLFLDMDQFKNVNDSLGHMMGDELLRQTAERLLGCV
REGDTVARFGGDEFIILLENIESEQASLSAERVVQAMRRPFRLGEHEHFCNVSIGISLYPEDDEHPEDLVRHADSAMYLAKAQGGAGYRFYTPDMNTRAM
ERLLLQNQLHQALELGQFQVHYQPQMDLRSGRICGVEALVRWQHPERGLVPPAEFIPMAEDTGLIEPLGEWVLRTAAREVRGWQDRGLPALNLSVNLSPR
QFRHPDLPGMVERVLAESGLEAERLELEITERLIIVDLEHTVDTLSRIARLGVRVSIDDFGTGHSSLAYLKRLPVHALKIDREFVDGIGQDSDDAAIAEA
VIALGRTLRLQVIAEGVETREQASFLREHGCDAVQGFFIARPMPAGELTGWLS-------
>tr|W0E5I6|W0E5I6_MARPU Diguanylate cyclase OS=Marichromatium purpuratum 984 GN=MARPU_11935 PE=4 SV=1
------------------------------------------------------------------------------------------HEGLIAVPDY
GRIQLANLTACQLLRLDEHELLGQR---LEPLPCWPAERGLDDELAA-VRIG-------RVLEAPDPRTPLEVRLRLIENP---SGPLVLVVLSHRERRR
IES----ALRESEARFRGIKL------------------------------PAIAVQGYDQRR-PEFREQMTGRDPPASELRLRRRDDSAVEVFSSHVMQ
RYSSGR-REMFCVDIDLTEIRASQARVDYLTHHDALTELPNRLLFQARLEHAIGRAEQGCGQLAVLFVDIDRFKGINDALGHAGGDALLRAVGRRLKARL
QRDDTIARFSGDELMVLTEHIAEADSARLAEQLLRAIAAPFELCDDELLITVSIGVALYPRDGADSTQLLHNAEVALRQAKHAGGNSYAFFTATLTRIAR
DRAQLEHELKRAIRDGELLLHYQPQVSLLDGALVGIEALVRWQHSQHGLLPPGRFIPVAESSGLTLALGEWALREACLQTRRWLEAGIAIGRVHVNVAHA
QIQRGALYDTTRRILDETGLDARHLGLEITEGVVMEHID-VITELERLRADGISLSIDDFGTGHSSLARLKQLPVDLLKIDRSFVGGIDTQGQDRDIIRA
IIALGEALGQEILAEGIETREQARALRRLGCRLGQGYLFARPLAPEALPDWIVSRA----
>tr|G2E0T7|G2E0T7_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_1910 PE=4 SV=1
------------------------------------------------------------------------------------------RDGLIVVIVA
GRILFANSVACRLLATSKSHLLGTR---VEHLSIWPERRFFQDAVDI-LSKA-----AEQQVALPRDDNPLEIRLSRFASD---ADLLLMTVCDPHDRLQ
SET----ALRESEARFRGIQL------------------------------PAIAVQGYDQRR-EPMRDGVVRIPIPSCELTLRRKDGSPVRVYSTHVMQ
CNSSGR-KEMFCVDLDLSPIRAWQERLDFLIHHDALTHLPNRVLFEARLDHAIRRAERDQDHLAVLFINLDRFKGINDSLGHPGGDRLLCEVAKRLRDGL
RRDDTLARFSGDELMVIIEDMADADAGRIAGNLLNTIVRPFQIGGREIFITASIGVALYPRDGGASTSLVRNAGFALRQAKKAGGNGYAFYTDALTEDAR
SYALLENGLRRAVRTDELRLYYQPQIRLGSGELIGLEALIRWEHPELGFLLPGRFIQIAEESGIIAAIGEWALHSACAQARSWLDSGLEFGRVYVNVAHS
QIHRGDLHRVTRRILDQTGLPAERLGLEITEGVAMERTDSIIAELDRLKSDNVGLAIDDFGTGYSSLSRLKQLPVDQLKIDSSFVRDIGGGGRDLDIVRA
IITLGHTLDLEVLAEGIETQEQHALLLAEDCRFGQGFLYARPMPPEALSGWLKDWL----
>tr|M2Y8H2|M2Y8H2_9PROT Signal transduction protein OS=Magnetospirillum sp. SO-1 GN=H261_13708 PE=4 SV=1
------------------------------------------------------------------------------------------PDVLYSIDAQ
GRIAWISPNAAAVFGYSVAELIGTD---AARLYIRPDE--RLEVVER-IRHAARA--EIEMRRKDGAAIWVAIYACAHYND-GRFAGINGAIRDITEVWQ
TRKTLQRFRRLSDVATEAIHF---QGKIIDMNKAFET---------------------------PLAKSMVAQQYEAPYEVRGVRKDGSVFPMEIYS--K
HSWMGANSVRVTSIRDLTQSKKQERKLQHQALFDGLTDLPNRVQALDRLGQQIDQARDRGRKVALLFVDLDEFKAINDSLGHEYGDELLVLASERLRQAA
GSAGVVARFGGDEFLVIMGDMEADAARTVASGIVESFAQPFTISRRELIATASIGLAIYPEDGRTQQTLLRNADIAMYQAKLAGRNRFCFFTSRMNEEAE
ARLRMEGELRRAVGTDQFHLAYQPLVEVSTGRAMGVEVLLRWSNPELGHVPPDRFIPQAETSGVIVPIGRMVLHTACRDARRWVEAGHTDLRLCINVSPR
QFQDAGFLDDVRAALGNSGLPPGNLELEITEGLLLTERGDVDVLLRTLTDMGILLSIDDFGTGYSSLSYLERFPFDTLKIDRSFMIGMLERQERKVLVET
IVAMASGLGLKVIAEGVETAEQLAHLAAINCDIAQGYLFSRPVPAAEIPPLLGRVF----
>tr|A0A0C2UFU1|A0A0C2UFU1_MAGMG Contig_11, whole genome shotgun sequence OS=Magnetospirillum magnetotacticum MS-1 GN=CCC_01543 PE=4 SV=1
------------------------------------------------------------------------------------------PDVLYSIDAD
GCFIWVSPNAEAVFGYSPLELIGTP---AARMYSRPEL--RAETATR-IREAVRA--EMEMRRKDGVSIWTAIYACAHFDE-GGFAGINGAIRDITEVWQ
TRKTLERFRRLSDVATEAIHF---EGKIIDMNKAFET---------------------------GLAKSMVAQQYEAPYEVRGIRKDGSVFPMEIYS--K
HSWMGEKSVRVTSIRDLTQSKKQERRLQHQAMFDGLTDLPNRVQALDRLSREIDLARERERKVALLFVDLDEFKAINDSLGHEYGDELLVLASERLRKAA
GDGGTVARFGGDEFLVILGDLEGATPQRVAAGIVERFSRPFAISRRDLIATASIGLAIYPDDGHTPQTLLRNADIAMYQAKLAGRNRFCFFTSRMNEEAE
ARLRMEGELRRAVGTDQFHLAYQPLVDVKSGRAVGVEALLRWSNPELGNVPPDRFIPQAETCGVIVAIGRMVLETACRDARRWVDAGHADLRLCINVSPR
QFQDAGFLGHVRAALAASGLSPANLELEITEGLLLTERGDVDVLLRALTDMGIQLSIDDFGTGYSSLSYLERFPFDTLKIDRSFMIGMLERQERKVLVET
IVAMASGLGLKVIAEGVETVEQLAHLTAINCDIAQGYLFSRPVPATEIPPLLERVY----
>tr|Q2W5V0|Q2W5V0_MAGSA Predicted signal transduction protein containing a membrane domain OS=Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) 
------------------------------------------------------------------------------------------PDVLYSVDAA
GRFIWVSPNAATVFGYSAEELVGME---AAALYAKPED--RVGTVRR-IRDAVRS--EVEMRRKDGISIWAAIYACALMDE-GRITGINGAIRDITEIWQ
TRKTLGRFRRLSDVATEAIHF---QGKIIDMNKAFET---------------------------SLAKSMVAQQYEAPYEVRGIRKDGSVFPMEIHS--K
HSRMGGDSVRVTSIRDLTQSKKQERRLQHQALFDGLTDLPNRVHALDRLAREIDMARDHGRKVGLLFVDLDGFKAINDSLGHEYGDELLVLAAERLRQAA
GDGGVVARFGGDEFLVIMGDMEGAAAGEVAAAIVDRFSQPFTISRRDLISTASIGLALYPEDGRTQQTLLRNADIAMYQAKLAGRNRFCFFTSRMNEEAE
ARLRMEGELRRAVGTDQFHLVYQPLVAVATGRAVGVEALLRWSNPELGNVPPDRFIPQAETCGVIVAIGRMVLETACRDARRWVEDGHADLRLCINVSPR
QFQDAGFLGDVRAALAGSGLSPANLELEITEGLLLTERGDVDTLLRTLTDMGVKLSIDDFGTGYSSLSYLERFPFDTLKIDRSFMIGMLERQERKVLVET
IVAMASGLGLEVIAEGVETAEQMAHLAAINCDIAQGYLFSRPVPAGDISPLLDRVF----
>tr|Q608F9|Q608F9_METCA Sensory box protein OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN=MCA1533 PE=4 SV=1
------------------------------------------------------------------------------------------GDTVIVSDLQ
GRIRTWNKGAERMWGYAAEEIIGQP---VTVLPPLAKQGEPGQILRR-VI-DVRF--ESRGLHKDGRDFPISLTVSPLFDE-NRLTGVSAIIRDITEMER
LKATLQLVEMVFQYS--VSVVLDPQFNFIRVNPAYARACRRDVAEFEGRNH----------FEL------------------------------------
--GKGEVEYLLFSLVDVTDRQKAEAQIRYLSYHDDLTGLPNRAYFQARLDQLIEAAARDRKQIALVVLDLDRFKTINDSLGHSVGDELLCQVAERIQDCT
GQGDFVARQGGDEFVVILADSDV-RAARVANAMISAIAKPAVAGGRTLIVTPSLGISLYPHDAGDSESLIKSADAAMYHAKSLGRNTYQFFSAEMSAVAT
ERLALENALHQALSNGEFRLYYQPQIEVCSRRLIGLEALIRWRHPEVGWVPPLRFIPLAEETGIIHRIGRWVLEEACRQQREWQAAGLCIVPVAVNLSPL
QLQKDDFPEQVEALLSGCRLAPGLLELELTETAVMRDVGRMSDMLRKLKERGTRFSIDDFGTGYSSLGYLNRFPVDKLKIDQSFIRDVTRREDHAAITRA
IIALAKQLHLKVVAEGVETAEQLEFLERAGCDGAQGFYFSRPVPADEIAGWLSREG----
>tr|L8MSH5|L8MSH5_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudanabaena biceps PCC 7429 GN=Pse7429DRAFT_4495 PE=4 SV=1
------------------------------------------------------------------------------------------TVGVFETTID
DKIIDVSISFCELLGYSNSQIRELN---YEQICY-PDDLSAYYVLKERLLSGDRCYLNVRYIREDGQ---------------------------------
---------------------------IVQVQSTDLDISGAKEPYFVNRFEDITDWERTDNKQDPKLLEAIAK-FSVPEIWTHRKKDGSQILVEVSAHTL
EYQNHRC--ELILINDVTQKIQAKAEIEHLAFHDSLTDLPNRVLFRDRLCAALVNASALPPLLAVMFLDLDRFKLVNDTMGHAAGDRLLIEVAKRLSDCM
FESTFLARMGGDEFMIFVSELQIESIQQFAQLILQSFEHPFLVEETPLHIGTSIGISLYPNDGMDEETLMKNADTAMFRAKERGRNHYQLYNHAIGAKVK
EYVAIENGIRQALERSEFQVFYQPQINLVTGKIDCMEALARWLHPELGWVPPNQFIPAAEEHGLIVRLGEWVLCTACQQNYLWQSQGLPAIRMAVNFSAQ
QFQVTDLCTRVMQILSETGLEPQYLEIEITESLVMQDQSTTIAVLKKLKSLGMSISIDDFGTGYSSLSYLRLLPVSKVKIDASFIRETPQNRDDAAITSA
IIAMAHNLNLRVIAEGVEREEQLEFLRSHNCDAVQGYLFSRPIPADEATLILQSQF----
>tr|L2E832|L2E832_9BURK C-di-GMP phosphodiesterase A OS=Cupriavidus sp. HMR-1 GN=D769_28797 PE=4 SV=1
------------------------------------------------------------------------------------------IDAVVAVDAR
NQITLFNAAAEALWGLERTTVLGQC---ASVLALGDLRVANDQ-----------SGQNLAIARADGTVRHVRLHITTFGTGVPAKQFAA-FLHDGSTGNE
GATLSPMLSLCLDHAENPVMITDAHGTICHLNGGFTRLLGYARYQAVGRRWQDLLMPI------PSLLAPLAAGLPLRNEALVPDKSGQPRWLSVAVSPI
MASRGGLVNTVWVLTDITATKVTQERIHRLAYYDALTGLPNRQLLLSRADDAVARANAHGTPLALLFINLNNFKRVNDVQGHGAGDRFLIEVASRLQFAT
ARDATVGRLSGDEFAVLLPGHGRDEALAIADELLRALDPPVTVAGLSLSPSASIGISMLTEQARDRETLLHHADLAVCQARKRSGNQICVYDTVLARRLG
DRRMLESELREAIGSGQLQMRYQPQIHLASGNLWAVEALARWPHPHRGDIAPTVFVPLAEESGLIVALGYWAVREACAQQARWRRLGAAVPAISVNLSPL
SIRDPALPDVVTQALRMHALPAGELTIEITESVFLDHTSEAEATIAALRKLGVRLSIDDFGTGFSSLSRLMQLPVDEIKLDRSFLVDLENSEATRTLVEA
VIRIGRARDLNVVAEGVTSALQRQFLLDQGCHVGQGFLFAQPLPAASIERWQPQPS----
>tr|A0A016XFT5|A0A016XFT5_9BURK Diguanylate cyclase OS=Hylemonella gracilis str. Niagara R GN=AZ34_06695 PE=4 SV=1
------------------------------------------------------------------------------------------VDAVVVIDQD
NRITLINAAAEALWGWPRDLALGRN---VSMLVPSELRSRHDGYINANRDTGVGTSREVPIQRRDGQLRWASMSISRVRVQ---VLYTA-FLKDVT----
AQRAERLLSQVADHSGGAITITGTDQRIVYVNSGFTQWLGYDSSEALGRPIQDLLRGA------EATRQAAMAGESLRTEVLFYSKSGRPLWISLTLNPV
RDTQDRLQNMVWVLIDITHTKMEREQIRQLAYYDALTGLPNRRLLLAQLERLLHDLRGDGGRLALAFVDLDRFKQVNDTHGHPAGDALLRALAQRLRDSA
RPGDVIARMGGDEFVLILPSCDASQANACMERLLAAWREPVAWADGTLHPSASIGIALCPEDGLDARQLMRHADLAMYQAKAAGGNSLRFYNATMNQRAQ
ERAQLEADLRRALRDDALEVHYQPQVDSRDLQLHGVEALLRWTHPRQGSIDPARFITLAEESGLMRELTRWVLNQVCSQLGLWRRRGLAIPHVAINLSAS
CFHHPDLPEQLIRSLHQHGLQANDLVVEVTESVMLTHDPVVMATVHAIGERGIALSLDDFGTGYSSLSLLHRLPIQELKLDRSFVLDIEESPRARALTDA
VLRIGHSLGQQVIAEGVETEAQRRHLLDSGCTTLQGYLIAPPMPALAFERWVGEKS----
>tr|J0JQS8|J0JQS8_RHILV PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Rhizobium leguminosarum bv. viciae WSM1455 GN=Rleg5DR
----------------------------------------------------------------------TDDSDLTERESRWNYALVGSGLGVWDHNYR
LDRKYYSPTWKTIRGMAPDEEADGDYAWL-QLVHPDDRDFVVHAIDRQNAGDNFQVFEYRERHKDGHWVWIECRGACVWDDNGVPTRIIGTDTDITARKE
AEETLSRLSLALEVSRIGVFEADIEHDTVEWDDRLIAIYGLQGAS---RQGDVWAKSLHPDRVLGLSDRSVESGSDFQQEYRIIRGDGAERVIRARSAFF
IDGNGHRK-LIGANWDVTELEAAKESIEHLALHDYLTGLPNRRYLDKMLDERAAECRAKGLALAILHIDLDRFKQINDTLGHRAGDAMLQHAASVLRTSV
RAVDFVARIGGDEFVILCIVDPAKKIASLAERVIRELRKPVRYEGHDCRFGASIGIAIDSGPKLDAKQMLLDADIALYRAKGLGRNRFEFFSASARRDII
SAKHLADEILIGLERNEFVPFYQLQFDARTLDVAGVETLARWQHPVHGLLTPDRFLDIAEDLDVVSTIDALILERAIADRKMWLKDGLPIPKISVNVSAR
RLADPDLGKKL----RALKIEPGTFSFELLESISLDDCDAVAANLKKLRKLGIDIQIDDFGTGHASIVSLLRLSPKTLKIDRELIRMLPQSAEQRKLVGS
IIDIGRSLNILVIAEGVETAEHIRILEELDCDTLQGYALARPMPAMQIPSFIRA------
>tr|A0A072CCA0|A0A072CCA0_RHILP Sensory box/GGDEF family protein OS=Rhizobium leguminosarum bv. phaseoli CCGM1 GN=RLPCCGM1_c1366 PE=4 SV=1
----------------------------------------------------------------------AGDAELAERESRWNHALVGSGLGVWDHNYR
LDRKYYSPTWKTIRGMAPDEVVAGDYAWL-QLVHPDDRDFVAHAIERQNAGDNYQIFQYRERHRDGHWVWIDCRGACVWDENGVPSRIVGTDIDITARKE
AEETLSRLSLALEISHIGVFEADIENDTVEWDDRLIAIYGLQGAS---HQADAWAKSLHPDRVLGLAGSSVESGSDFQQEYRIIRGDGVERIIRARSAFF
VDGNGHRK-LIGANWDVTELEAAKESIERLALHDYLTDLPNRRYLDKMLEERSAECRAKGLALAILHVDLDRFKQINDTLGHRAGDAMLQHAANVLRNSV
RAADFVARIGGDEFVILCTMDAAKKIGGLAQRIIHKLRKPVRYEGHDCRFGASIGIAIDSSPKLDAKQTLLDADIALYRAKGLGRNRFEFFSASARRDIV
LAKHLADEILIGLERNEFVPFYQLQFDARTLDVTGVETLARWQHPRHGLLAPDRFLDIAEDLDVVSTIDALILERALADRRAWIKEGLSIPKVSVNVSAR
RLADPDLGKKL----RALKIEPGAIAFELLESISLDDCDLVTANLKKLRKLGIDIQIDDFGTGHASIVSLLRLSPKTLKIDRELIRLLPQSAEQRKLVGS
IIDIGRSLNIRVIAEGVETADHIRILEDLDCDTLQGYALAQPMPAMQIPSFIRA------
>tr|J1SIQ1|J1SIQ1_9RHIZ PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Rhizobium sp. CF142 GN=PMI11_06705 PE=4 SV=1
----------------------------------------------------------------------PDDSDIAERESRWNYALVGSGLGVWDHNYR
LDKKYYSQTWKSIRGMAPDEEADGDYAWL-QLVHPDDRDFVVNAIERQNAGDDYHVFQYRERHKNGQWVWIECRGAPVWDEDGAAQRVVGTDTDITARKE
TEEMLAQLSLALQISDIGVFEADIDHGTVEWDDRLIAIYGLEDAD---RFANAWLSTVHPDRVNETVESNVNNETGFHQEFRIIRGDGAERIIRARSAFF
VDGNGCRK-LIGANWDVTELEAAKESIEHLAFHDYLTGLPNRRYLDKMLEERSAHCREEGLALAILHIDLDRFKQINDTLGHRAGDHMLKHAARVLRDSI
RGTDFVARIGGDEFVVLCIVDTPKKIATVAERIIRELRKPIKYEGHDCRFGASIGIAIDSGPKLDEKQLLLNADIALYRAKGSGRNRHEFFSNAARRTIL
TAKRLADEILIGLERSEFLPFYQPQFDARTLDIAGIETLARWQHPEHGLLAPDRFLDIAEDLDVVSTIDALILEQAIADRKAWIREGFTIPRISVNVSGR
RLSDPQLGKKL----RSLKIEPGTVSFELLESISLDDCDAVTANLKKLKKLGIDIEVDDFGTGHASIVSLLRLSPKTLKIDRELIRHLPQSAEQRKLVRS
IIEIGRSLNILVTAEGVETADHVRILQELGCDMLQGYALARPMSGLQFPAFIRG------
>tr|S3HYF4|S3HYF4_9RHIZ Diguanylate cyclase OS=Rhizobium grahamii CCGE 502 GN=RGCCGE502_10456 PE=4 SV=1
----------------------------------------------------------------------QNGAELSERESRWNYALVGSGLGVWDHNLR
LGKRYYSDTWKVMRGMAPDEEADGDYAWI-ELIHPDDREFVVKAIDRQNAGDNYQIFEYRERHRDGHWIWIECRGACVWDENGAPARLVGTDTDITERKE
AEERLAHVSLALDISNIGVFEADIENGTVDWDDRLLAIYGITDTS---PATNAWEASLHADRVLATINDSVTNNTDFEHEFRIIRQDGIERVIRAKAAFF
FDSDGRRK-LIGANWDVTELESAKEDIERLALHDYLTELPNRRYLDRMLDERSTECRRTGLTLAILHIDLDRFKQINDTLGHRAGDAMLKHVAQVLKRNV
RSTDFVARIGGDEFVVLCTLDVTKKISNLAERIIRELCKPIRYEGHDCRFGASIGIATDSGPALDAKQLLLNADIALYRAKSGGRNRHEFFSTDERRRII
ASKRLADEILLGLERGEFVPFYQLQFHARTLEVAGVETLARWQHREHGLLAPDRFLAIAEDLDVVSTIDGLILEQALADRKRWADEGLRIPKIAVNVSSR
RLADPNLAKKL----RGLKIEPRTISFELLESISLDDCDAVIANLRHLRRLGIDIEIDDFGTGHASIVSLLKLSPKTLKIDRELIRMLPHSAEQRKLVRS
IIDIGRSLNILVTAEGVETMDHVRILYDLGCDMLQGYALARPMPAMQIAPFVRA------
>tr|A0A0B4X3X6|A0A0B4X3X6_9RHIZ GGDEF/EAL domain-containing protein OS=Rhizobium gallicum bv. gallicum R602 GN=RGR602_CH02082 PE=4 SV=1
----------------------------------------------------------------------PDTSDLAERESRWNYALVGSGLGVWDHNNL
IGTKYYSDTWKEIRGMAPHEEADGDYEWL-KLLHPDDRDFVIMAIEKQIAGDDYHVFEYRERHKNGGWVWIECRGACVWDENGAPARIVGTDTDITARKR
SEEMLEHLSLALEISRIGVFEADLNAATVEWDDRLLAMYGLEGTP---RVLEAWEQALHPDRTLKNLDASLEKDRGLLQEFRIIRGDGAERVIRSRSAFF
LDADGNRK-LIGANWDVTELEAARESIEHLALHDYLTELPNRRYLDRMLDERSAGCRENGLTLAILHIDLDRFKQINDTLGHRAGDAMLKHAARVLKESV
RASDFVARIGGDEFVVLCTIDSSKKLSNMAARIIRELSKPVRYEGHDCRFGASIGIAAESGKDLDAKQLLLNADIALYRAKGAGRNRHEFFSKDARRTII
AAKRLSDEMLLGLERNEFIPFYQLQFHAQTLEVAGVETLARWRHPEHGLLTPGHFLTIAEDLDVVSAIDGLILEKGLADRAAWARDGFVTPKLSVNVSSR
RLADPGLGKKL----RVQKIEPGILSFELLESISLDDCDAVLTNLRQLRKLGIDIEIDDFGTGHASIVSLLKLSPRTLKIDRELIRMLPQSAEQRKLVRS
IIDIGRSLNILVTAEGVESMDHVRILSDLGCDMLQGYALARPMPAMQIPAFVRN------
>tr|A0A068T7K9|A0A068T7K9_RHIGA Neorhizobium galegae, complete genome OS=Rhizobium galegae GN=RG1141_CH17030 PE=4 SV=1
----------------------------------------------------------------------RQVEELIERESRWDNALVSSVSGVWDHNYT
TGQKYYSPVWRQIRGMSPEDPLAASTEWL-ELVHPDDHDHVIHAIERQNAGDAYAVFDYRERHKQGHWIWIECRGACVWDANGKATRVVGTDTDITARKA
AEETTAQMSMALEISGIGVYESDFSTGEVEWDERMFRIYGLAKSE---EVIGLWESFLHPGRVQANVLDNIEEGKRFFDEYRVILRDGSERVIRTRTMSF
IDGNGHQK-MVGANWDVTELEAARSSIEHNAMHDYLTDLPNRRYLDEMLDRMAAECARDRHGIAILHIDLDRFKQINDTLGHSAGDTMLKHVAKVLKGTI
RKGDFVARIGGDEFVILSKFEGSRKLSHLADRIIKELRKPVSYEGHDCRFGASIGIACHTGADVDARQLLLNADIALYRAKNRGRNRHEFFSADTQNEII
STKRISDEILLALERDEFIPYYQLQFDAATLEISGVETLARWMHPERGMLSPDKFLEMAEELDVVSVIDGTILDKALADFRDWRSNGLSIPKLSVNVSYR
RLHDASLPRKL----KKLKIEPGTVSFELLESIFLDDCDDILKNLARIKKLGIDIEIDDFGTGHASIISLLRLNPRALKIDRELVRLVSQSQKQRKMVGS
IIEIGKSLNIEVVAEGVETTEQIRILRDLGCDVLQGYALARPMPRSSIPDFILS------
>tr|A0A081CVM9|A0A081CVM9_9RHIZ Uncharacterized protein OS=Rhizobium rubi NBRC 13261 GN=RRU01S_13_00630 PE=4 SV=1
----------------------------------------------------------------------LREQDIAQRESRWNSALVSSLSGVWDQNFV
TGEMYGSETWRAIRGMTLEDPIETDFRWV-DLIHPDDREHTLHCIERQNAGDAYTAFQYRERHKNGHWVWIECRGACIRDEYGKAVRIVGTDTDVSERKA
TENEMERISVALEASQVGVFEVDFDAGETIWDSRMYEMYKVDPNT---PVIGLWETRVHPDRVHKNVWNMIQELQPFSEDYRIVMEDDSLRYIRARSLPF
IDIDGRRK-MIGVNWDVTELEAAKLSIEHNAMHDYLTDLPNRRYLDDLLERRTLAADKTGSGIAILHIGLDRFKQINDTLGHRAGDVMLKHVAEMLRRNL
KTNEFIARIGGDEFVLLLPFNGYRKIASTADRLVKELRKPVLYDGQECRFGASIGIACGMGPNFDYKQLLLNADMALYNAKKSGRNRYEFFSSDTQDWLI
NTKRVSDEILMALERDEFVPYYQFQFDTHTLDICGVETLARWNHPIDGILTPDKFLDIAEDLDVVAAIDGIILEKALVDFKRWRADGLPIPKVSVNVSAR
RLHDPLLTKTL----DGLKMEPGTLSFELLESIFLDDSNIAISNMQKLRALGIDIEIDDFGTGHASIISLLKVSPTTLKVDRELVRLAPQSTEQRKLLGA
IIDIGHSLGIKVVAEGVETADHIRILQAMNCDSLQGYALCRPLPAGHINAFVEA------
>tr|A0A0D0KQV6|A0A0D0KQV6_RHIRD Strain MEJ076 contig_30, whole genome shotgun sequence OS=Rhizobium radiobacter GN=RU07_19435 PE=4 SV=1
----------------------------------------------------------------------LREREIAMRESRWNSALVGSLSGVWDQNFA
TGEMYGSETWRSMRGMAPDDPIEANLEWL-TLVHPDDRAHTVHCLEKQTEGDAYAAFQYRERHKDGHWIWIECRGACIRDENGKALRIVGTDTDVTERKA
SESDMERMALALEASQVGVFEVDFETGVTTWDDRLYEIFGIDKSM---PIVGLWESRVHPDRVLVNVSDKMEKLEPFTEEYRAILPDGSLRYIRARSLPF
IDIDGKRK-MIGVNWDVTELEQARINIEHNALHDYLTDLPNRRYLDEVLTRGDLFTGQAGPGLAILHIDLDRFKQINDTLGHRTGDVMLKYVANLLRKAS
KKKEFVARIGGDEFVFLSPFNGDRKIESMAKRLIKQLKQPILHEGHECRIGASIGIACGIGADMDYKQLLLNADIALYNAKKRGRNRFEFFSSDTQDWLI
NTKRVSDEILTALERDEFIPYYQFQFCAQTLDITGVETLARWNHSAEGILTPDRFLAIAEDLDAVSAIDSIILKKALVDFSKWKAAGLSIPKLSVNVSAR
RLHDPALSQSL----DGLKIEAGTLAFELLESIFLDDSDITLHNLKTLRELGIDIEIDDFGTGHASIISLLKVSPHTLKIDRELVRLIPQSNEQRKLLGS
IIDIGRSLGIRVVAEGVESAEHIHILQDMGCDALQGFALCRPLPAEAVADFVAA------
>tr|A0A021X1H9|A0A021X1H9_9RHIZ Diguanylate cyclase OS=Shinella sp. DD12 GN=SHLA_69c000030 PE=4 SV=1
----------------------------------------------------------------------RNALELAERESRWNHALESAGQGVWDHDFA
RGDLFYSRQWRAIRGLRPDEPIDASLGWL-QCVHPDDRAHVLEEIHKQETGEPFNMFSYRERHKNGHWVWIESRGAVVYGADGKPTRIAGTDTDITERKE
AEERLAQMSLALGVSRIGVFDVNLQTGEVRWDDRMIEMYGVTEKP-----DGTWERTLHPQKAKAKVNDNLTRSQDFANEFRIIRGDGEIRHIRSRAAPY
VDIAGAPR-LIGVNWDVTELEAARARIEYTALHDHLTGLPNRRYLDTTIEAAARQAQQTGSRLAVLHIDLDRFKEINDTLGHLAGDQMLVHAAGVLNELK
GPDDFVARIGGDEFVFLSAG-SARNLAMLAEAIVAAMRKPVTFNGHICRFGASVGIASQSGAGIDAKQLLVNADLALYRAKNRGRSRHEFFTSDFQAQII
VNKQTADEILTGIEQQRFLPYYQPQFCARTLDVVGVETLARWDHPTRGILAPDTFLKIAEDLDCVAMIDRIVLEKSLGDYADWQALDLGIEKISVNVSSK
RLHDPELARSL----HTLAIRPKSLSFELLESIFLDDCDTVLENLAEMRKLGIDIEIDDFGTGHASIISLMKLSPRRLKIDRQLVKPVSRSPGQRKLVGT
IVEIGRSLNIEVVAEGVETPAHVAIMRDLGCDILQGYALARPMPAAAIPDFVRR------
>tr|H4FAS5|H4FAS5_9RHIZ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhizobium sp. PDO1-076 GN=PDO_2767 PE=4 SV=1
----------------------------------------------------------------------ATIADLEISASRWNNALRSSLSGVWDQRF-
DGQLYYSDVWRELRGMAPDDPIPTTTEWL-EMVHPQDRERTLHCIARQNAGDDYTVFQYRERHKDGHYIWIECRGACVWDENGQPARITGTDTDVTARKE
QEEWLERISLALDVSRIGVFETDFAAGTSDWDDSMRRIFEVKQGD---NIIEFWESKLHPDRTIAHVEERISKLEPFTDEYRIIADDGSVRYIRSNSLPY
IDHDGHLK-MIGVNWDVSELEQTRAKAEYSALHDYLTGLPNRRYLEAKLDEWQKSTTNTFGRLAVLHVDLDRFKQINDTLGHSAGDAMLKHAAGILRTNI
RTGDFVARIGGDEFVLLVAFDGKKTLSQLADRIIAELSQPVAYDGHQCRFGASIGISHSDGDIIDPQQMLLYADIALYNAKNLGRNRHEFYSQGSRKILA
NHRRLSDDLLRALENNEIVPFYQLQFDARSRAVVGAECLARWQHPEHGLLTPDRFLPIAEEMSVLARIDGLILEKALVDFRQWRAMGMGIPKISVNVSAK
RLNDPRLPQLL----TDLGIEPGIVSFELLETVFLDSHDVAMSNLAHLRDLGIDIEIDDFGTGHASIVGLLNLKPKTLKIDRQLIHKLPSSQEQRVLAKS
IIGIAKSLNIRVIAEGVETEDHVTILKKLGCHTLQGFGLAMPMDFTATTQFLIN------
>tr|W8I246|W8I246_ENSAD Sensory box/GGDEF family protein OS=Ensifer adhaerens OV14 GN=OV14_2944 PE=4 SV=1
----------------------------------------------------------------------AEIAGLRNDETRWKYALESALEGVWDHDFS
TGNLFYSATWKRLRGLADDAEVDGALRWI-ENVHPDDRAHVMASIGRQDSGETYNTFQYRERHADGHWVWIESRGASVYGPDGKPTRIIGTDTDITPRKE
AEARLEEISLALDVSKIGVFDHNLETQETLWDERILGIYGLDPKA---GASRSWEDMLHPDKAIARVNDGVAAGAPFTNAFRIVLANGEIRHIRANTAFY
VDRDGTRK-LIGANWDVTELEEARIRIEYNALHDYLTDLPNRRYLDQILADDPT-------LNAILHLDLDRFKQINDTLGHQAGDAMLTHAAAILRSHA
DQDDFIARIGGDEFVILCRRGRGDELGDLAARIVHAFRRPIPYDGQLCRLGASIGIAWRGEVETDPKQLLMNADIALYRAKSLGRDRFEVFSEQIQNQIL
SAKRTGDDIRQAIEEGQFVPYYQPQFDAHSLELTGVETLVRWDHPERGILPPSHFLKVAEEINALPAIDRNIVEMAYADFAAWGRAGLTVPKISVNVSSR
RLRDPSLISDL----RAMNIPPGVMSFELLESIFLDDLEEIAATIAALNTLGIEIEIDDFGTGHASIIGLLNLNPARLKIDRALVGPINESAKQAKLVRA
IIDIGHSLNIKVVAEGVETWEHAAILRELGCDILQGYALAKPMSRLDFEQRIKS------
>tr|K2QF90|K2QF90_9RHIZ PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Agrobacterium albertimagni AOL15 GN=QWE_10772 PE=4 SV=1
----------------------------------------------------------------------RQLNDVQERESRWNHALVGSLLGVWDQRS-
SGELYYSDVWREIRGMGPNDTFPPTMDWL-ELVHPQDRERVLHCIERQNAGDDYSVFQYRELHRDGHYVWIECRGACVRDEDGKPARIIGTDTDISARKQ
QEEWLEGLSLAIDISGIGIFETDFDAGTSEWDEGMRRIFEVDNDC---EVIGFWESKLHPERTLAYVATKIAELKPFTDNYRIIARDGSTRYIRSNSLPF
MDHDGRLK-MIGVNWDVTELERTRLEAEQSALHDYLTGLPNRRYLEEKLEEWRVGKGTLGSGIAILHIDLDRFKQINDTLGHGAGDAMLTLAARILRDNI
RVSDFAARIGGDEFVVLIDHDGAATLAAIASRIIDQMRQPAWYNGQECRFGASIGIAHTLARDIDPKQLLQNADIALYKAKNLGRNRFEFYKQASRTLLA
DTNRLSSELLRALENDEIFPHYQLQFDARTRAVVGAECLARWRHPTRGILGPDKFLPIAEEYGVLAQIDGLILEKALRDLEVWREEGIAPPKISVNVSAR
RLTDPELARGL----ADLHIKPGTVSFELLESVFLDRQDAVMSNLDMLRRLAIDIEIDDFGTGHASIVGLLNLKPTTLKIDRQLIEDVPDSQEQRILVKS
IIQIARSLGIKVTAEGVETEEHARILARLGCDVLQGYGLARPAGFSDVSEHLRN------
>tr|A0A069I3C5|A0A069I3C5_ENSAD Uncharacterized protein OS=Ensifer adhaerens GN=FA04_05005 PE=4 SV=1
----------------------------------------------------------------------NEIAGLRNDETRWKYALDGALEGVWDHDFE
TGDLFYSATWRRLRGLSEDAQVDGTLNWI-QNVHPDDHAHVRAAIERQDSGEIFNTFEYRERHADGHWIWIESRGASVYWPDGRPSRIIGTDTDITARKE
AEARLEEVSLALGVSKIGVFDFNLDALRDDWDERMFEIYGLDLAD---GASETWENSLHPDAVVLRTNEGIASGKPYSNAFRIVRPDGSVRHIRSNAATY
VDHLGTRK-LIGANWDVTELEQARIRIEYNALHDYLTDLPNRRYLDQMLTENVA-------VNAILHIDLDRFKQINDTLGHQAGDAMLTHAAAILRAHA
RHDDFIARIGGDEFVILCRRNRDPQLTELAERIVHAFRRPIPYDGQLCRLGASIGIAFKGGEDIDAKQLLMNADIALYRAKSVGRDRVEVFSELIQTQIL
NAKRIGDDIRQAIEEGQFTVYYQPQFHARSLEISGVEALVRWNHPERGILTPFHFLKVAEEINVLPAIDRKVVELAYRDFQSWQKEGLGVPKISVNMSSP
RLRDPGLIADL----RDMRIPPGILSFELLESIFLDDPEEIAGTISALGDLGIEIEIDDFGTGHASIIGLLNLNPARLKIDRALVGPMTEGAKQAKLVRA
IVDIGHSLNIAVVGEGVETWEHAAMLRDLGCDVLQGYALARPMDRLELEQRLRR------
>tr|A0A0D5LQR5|A0A0D5LQR5_9RHIZ Uncharacterized protein OS=Martelella endophytica GN=TM49_14200 PE=4 SV=1
----------------------------------------------------------------------EKETRTAARERLWNYALVSSGLGVWDHDYR
AGAYFYSPTWRTIRGLPVNGDLHSSTEWL-QSIHPDDRDFVAEAIEKQKLGDRFMNFEYREKHADGHWMWIECRGDAVFFDDNRPARVVGTDRDISDRKT
SEALLTRTRLALKTSQIGVFEHNRSTGDVSVDDRLSEIWGFTDHP---ETPSRFTALIHPDRALEKRLAAGGDDIPVEDEFRIFRSDGALRHVRHLVTSQ
KNAEGIEY-LVGINWDVTELERARYDVENAALHDYLTALPNRRFLEEELARRIEIES--TSGFALMLVDIDAFKLVNNTYGLSGGDSVLNHVAQVLLHVS
KHNDFVARIGADEFVLVSSYECGDALESTARRILLEISKHFEIDGTRCKISACIGVATVESVEKTASGLLKESDIAVRRAKSEGPNRIVFFERGLQAAAV
ASRAPADALIEAVENDAFVPFYQPQYDARTRTLAGVETLARWRRPDGTFGEPGSFIPLAETLNLMTLIDTSILRQALNDYGRLSQLGIAPPRLSLNLSPR
RLSDPALIASL----QEIDLPEGRLAFELLESIFLDDQDVSAYNLREIRRLGIDIDVDDFGTGYTSISGLLKVMPNGLKIARELVLPLVLSREQRAIIKS
IVDIGRALDIRVIAEGVETEQHADILTELGCDTLQGFWLARPMPYEALSALLVD------
>tr|K9ELC5|K9ELC5_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Leptolyngbya sp. PCC 7375 GN=Lepto7375DRAFT_6581 PE=4
----------------------------------------------------------------------ELTKKLEISEERYALAVQGANDGIWDWDLR
TNTICYSLRWKTMLGLNHSNL-SESPEWL-SRIHADSRSEFEQTLQEHLAFQSNFQFEYRMLHADGSYRWMLTR-GMAWDDEGQPYRIAGSQTDTTERKH
LEQSLYQEKITLHSIGDAVITTDAHGYIKDFNPVAEKLTGWKANDAKKRSIEVCTIV-DSAPLQNPALQAIKEKKASLSKHPTLIKTGQEFAIGDSAAPI
RADNGEVLGTVLVFHDVTEERGRAKQLAWQASHDPLTELFNRKKFMHALDKAIEELHGAESQHMLCYMDLDHFKAVNDTCGHAAGDQLLQQVADLWRRQI
RQTDVLARLGGDEFGLLLYN-CKERATEIAKSFCQGIQGRFVFDGKMFNIGVSIGIVPMVSNTVSSKQVMQLADKACYVAKNKGRNRVQIYHSDDVGISR
QTEDVFSRVTEALDGDQFQLYYQTIESAVSSDIRLCEILLRLPTRTGEIAPPMAFLPTAERYNLMPRIDRWVVESFFSYLTSHT----PMPKYSVNLSGA
SINDENFIGFLEEQLRKYPVNPAILCFEITETLAIANLQKAADLILKLKKIGCHFALDDFGSGMSSFSYLRHLPVDYLKIDGNFVKESPTDDLLCAMLAA
INNIGHIMGLKTIAEYVESPAVLKKVQALGVDYVQGYAISHPQPLV--------------
>tr|U9VUB4|U9VUB4_9CYAN Pas domain s-box diguanylate cyclase domain-containing protein OS=Leptolyngbya sp. Heron Island J GN=N836_11475 PE=4 SV=1
----------------------------------------------------------------------ELTKKLEISEERYALAVQGANDGIWDWDLK
ANTICYSHRWQAMLGLDQSDI-SSSPEWF-SRIHEEHRSAFERKLKEHLEFHSHFKCEYRIRHDDGRYRWMLTR-GMAWDEQGNPYRMAGSQTDITDRKQ
LEQSLYQEKITLHSIGDAVITTDSSGNIKDFNPVAEKLTGWQAREARRRPIEVCKIV-DSKPLQNPALQAIKEKRASLSNHPTLIKTGQEFAIGDSAAPI
RSANGEVVGTVLVFHDVTEERGRAQQLAWQASHDALTELFNRKKFIHALENAIDELGSSESQHMLCYMDLDHFKAVNDTCGHAAGDQLLRQVADLWRGQI
RQTDVLARLGGDEFGLLLYH-CKTRATQIAEAFCKSIQGRFLYDGKVFSIGVSIGIVPITSNHSNSEQVMQLADAACYAAKNKGRNRVQVYHPDDDGIHR
QTKDVFSQVTAALDEDQFQLYYQTIESALSTDVHLCEILLRLPAQTGDLAPPMAFLPTAERYNLMPRIDRWVVKSFFTYLVGRT----PTPKYSVNLSGS
SINDESFIGFLEEQLKQYPINPEILCFEITETLAIANLQKAADLILQLKKMGCHFALDDFGSGMSSFSYLKHLPVDYLKIDGNFVKEAPTDEVVCAMLQS
INNIGHIMGLKTIAEYVENEAVLEKVQALGIDYAQGYAISYPQPLI--------------
>tr|U7FWK0|U7FWK0_9GAMM Uncharacterized protein OS=Alcanivorax sp. P2S70 GN=Q670_01955 PE=4 SV=1
----------------------------------------------------------------------DAEKALQENRRRLELAVTAGGVGIWQYHLG
RDELLWDDKMYELYGVTPGGETEGTLMWS-DRVHPDDLPAANEALAKAIDE-GELDIGFRVFRPDGERCFIRAK-A--YLPGDGDGMVLGTNWDITAEQA
MQASLAREKVTLSSIADAVIATDHNGIITFMNPIAESLTGWREKEACGQHVSVLVLS-TEEPKISPVSVALNGGDVFLREGSFLLRDGSRYEIQDSAAPL
KDNAGVVTGAVMVFRDVTTRRAMQKKLRYHATHDSLTGLTNRREFENILQLTLDE--REKEQGMLCFIDLDRFKVVNDTAGHVAGDALLRECARVIARQI
RDGDVLARLGGDEFGLLLRG-CPDQAVQIAERLIQALDERFAWKDSLYDIGGSVGLVQLDENVATVEEAMSRADVACYAAKHRGRGQVSVYTPDDSEASR
RHVELAAGLRESLEANRFLLFAQEIRPIADCP-GHYEILLRLRDRNGDILNPGAFIPAAERYQMMPHIDRWVLTQLLVKLGEQL---LAYPKLAINLSAT
SLDDPSFIPFLDELLAATPVPPQRLTFEITETTVVNQLSTASEVLSRLREQGCKVALDDFGSGFSSFNYLKHFPVDFIKIDGSFVRNLMFSSVDHTIVES
INEVAHRLGVKTVAEYVEDDALIPVLQKAGVDYVQGYAIGRPQPLDYLLEQLSK------
>tr|A0A095UE35|A0A095UE35_9GAMM Signal transduction protein OS=Alcanivorax jadensis T9 GN=T9A_02197 PE=4 SV=1
----------------------------------------------------------------------EAEHALAESRHQLQLALSAGGVGIWQYNTV
TGQLDWDERIYEMYGVKPGQQGDGTLIWY-DRIHPDDLAQLQPRLQQVMDA-GELDGEFRILTPAGEERYIRAR-AETLVGPDKVPLMVGTNWDVTAERT
MQHSLAHEKVTLNSIADGVIATDQGGRITFMNPVAESLTGWRERDAEGEPVTVLQLS-DEEAPTNPIAVALRGGDMFLREDCFLLRDGSRYEIQDSAAPV
KTAEGEVKGAVMVFRDVSARRAMQKKLRYHATHDALTGLTNRREFENTLQQTLDE--GIAEHSVLCFIDLDRFKVVNDTAGHVAGDALLRECARVIGRQI
RDGDVVARLGGDEFGLLLRS-CPDKAVQIAERLIAALGDRFAWKDSLYDIGASVGLVQLDGNLISVEEAMSRADVACYAAKHRGRNRVSVYTPDDSEASR
RHLELAAGLRESLESNRFLLYAQEIRPIGTDA-SHYEILLRLRDRNGDILNPGAFIPAAERYQMMPHIDRWVLTQVLVTLSEEL---AALPSLAINLSAT
SLDDPTFIPFLEELLDRTTVAPERLTFEITETTVVNQLSSASELLARIRQKGSKVALDDFGSGFSSFNYLKHFQVDFIKIDGSFVRNLLYSSVDRTIVES
ISEVAHRLGVKTVAEYVEDIAMIPILEQAGVDFVQGYAIGRPQPLTMLFEQLAA------
>tr|B4X4M1|B4X4M1_9GAMM PAS fold family OS=Alcanivorax sp. DG881 GN=ADG881_3295 PE=4 SV=1
----------------------------------------------------------------------LSEQALQESRHRLQMALEVGGVGIWQYSPQ
SDVLFWDERMYELYGVQPGAPGDGTLIWR-DQVHPDDYTDINAAFQRVIAG-EDLDTEFRTLRPGGEIRHIRVR-AETVRSDGAETLVVGTNWDVTAEKG
MQQSLAHEKVTLTSIADGVVATDEIGRVTFMNPVAESLTGWREAEAEGLPVDILMLS-DDNPIPNPISVALSGGDVFLREGSMLQRDGSRYEIQDSAAPL
KSADGQVTGAVMVFRDVTSRRAMQKKLRYHATHDALTGLTNRREFENTLQESLDE--PGAEHSMLCFIDLDRFKVVNDTAGHVAGDALLRECARVIGRQV
REGDVVARLGGDEFGLLLRH-CPQRAIQIAERLIGALGDRFAWKESLYDIGASAGLVQLDANVITVEEAMSRADVACYAAKHRGRNRVSVYTPDDSEASR
RHLELAAGLRESLESNRFLLYAQEIRPIDTEP-SHYEVLLRLRDRNGDILNPGSFIPAAERYQMMPHIDRWVLTQLLVSLSDEL---AALPQIAINLSAT
SLDDPTFMPFLESLLSKTSLSPERLTFEITETTVVNQLSSASDLLGRIREQGCKVALDDFGSGFSSFSYLKHFPVDFIKIDGSFVRNLLHSSVDRTIVES
INEVAHRLGVKTVAEYVEEHALIGVLEEAGVDFVQGYAIGRPQPLSALFEQQHR------
>tr|Q0VLR7|Q0VLR7_ALCBS Uncharacterized protein OS=Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2) GN=ABO_2433 PE=4 SV=1
----------------------------------------------------------------------LSEQALQESRQRLQMALEVGGVGIWQYSPQ
NNVLFWDERMYELYGLQPGAPGDGSLIWR-NSVHPDDYTEITTAFQRVIDG-EDLDAEFRVCWPGGEIRHIRVR-AETARADGGDALVLGTNWDVTAEKS
MQQSLAHEKVTLTSIADGVVATDEAGRVTFMNPVAESLTGWREEEAEGMPVDVLKLS-EDNPSPNPITVALNGGDVFLREGSMLQRDGSRYEIQDSAAPL
KSAEGQVTGAVMVFRDVTTRRAMQKKLRYHATRDALTGLTNRREFENTLLESLDE--EGPENNILCFIDLDRFKVVNDTAGHVAGDALLRECAQVIGRQV
REGDVVARLGGDEFGLLLRH-CPQCATQIAESVIAALGERFAWNESLYDIGASVGLVQLDADVSTVEEAMSRADVACYAAKHRGRNQVSVYTSDDSEASR
RHLELAAGLRESLESNRFLLYAQEIRPIDSEQ-SHYEVLLRLRDRNGDILSPGAFIPAAERYQMMPHIDRWVLTQLLITLSEDL---AALPHLAINLSAT
SLDDPTFIPFLESLLNQTPLSPERLTFEITETTVVNQLSSASDLLGRIREQGCKVALDDFGSGFSSFNYLKHFPVDVIKIDGSFVRNLLHSSVDRTIVES
INEVAHRLGVQTVAEYVEELALIPVLEEAGVDFVQGYAIGRPQPLSALFEQQQP------
>tr|B8GTY7|B8GTY7_THISH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) GN=Tgr7_0171 P
----------------------------------------------------------------------AAERTLREREHQLRTAITSAPMVLFSLDRH
GNFMLSEGKGLEGLGLVPGQAVGMNAE------MYGAYPEVAEGLRRALSG-P-VQLESR----VEGRCFLH-H-WQPPDEAAGGWGVLGVSYDITAQCL
AEQALSGERTTLESIADGVITADVAGRVAYMNPVAEQLTGFTLNQARGRPMEILRVE-DLELLPDPVERCFNGGSPVFSEESRLRPDGESYAVRLTASPL
RDGEDGISGAVLVLHDFSMLWDMARQLSHQARHDALTGLINRREFEDRVREALESARRSSRSHALCYIDLDQFKVVNDTCGHVAGDELLRQLAAALPRHI
RDTDTLARLGGDEFGLLLEN-CPDRALSICHQLLAEVAERFMWQGRRFDVGMSIGLVAIDGASASLSEVLSEADSACYVAKEQGRNRVYVSRPGDQALKT
RFGEMLGRIREAMEEERFELYCQPIRPISGVP--HFEILLRLKAEDGSLVEPGAFIPAAERYNLMPQVDRHVIRSVFAMLADSD---FALKQVGINLSGQ
SLGQEDLLDFVTEALHYYGLPAHRFCFEITETAAIANLSSAAGFIRELRDMGCAFALDDFGSGLSSFNYLKHMPVDYLKIDGSFVQDVLTDPVDAAMVGA
IHRIGRVLGVKTIAEFVESEAVLEHLREIGVDYAQGYGIGRPKPFRDCSLFQTG------
>tr|D3SEF9|D3SEF9_THISK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thioalkalivibrio sp. (strain K90mix) GN=TK90_0489 PE=4 SV=1
----------------------------------------------------------------------QSEQALHELETQLSATIRHAPLLLFGLGPD
GVFTLSEGAALHSLGLQPGEVVGQDAL------LYADHPAILSAIDRALEG-Q-FQSEVK----VGDSHFAI-S-WMPEVAQSFQPGVLGVAWDITSLRA
AEASTASERTTLHSISDGVLTADTTGRLTYLNPSARDLLGVDATAVQGQRLELLELE-DTHRVMNPVTQCLETGMTE-SPERVLRPDGAARVVRLLVSPL
RRPDHHSEGVVVVLHDHTELWRMTQQLNHQATHDELTGLCNRREFERRLDEALRTLEEGDTPHALFYMDLDQFKIINDTCGHQAGDALLRELADLLPAHI
RDSDTLARLGGDEFGLLLRH-CPERAEAIGNKLLATAQGRFSWEGRRFDVGMSIGLVPIEGPGQNLPEVLSQADSACYVAKDLGRNRLYTWKPSDQILRR
RHGEMVGRLRAALEEARFVAYAQPVKPLNDLPLDHVEILLRLHGEDGTLITPGAFIPAAERYHLMPEIDRHVVELVFRQLADHR---DRNPHVSINLSGQ
SLAQDGMLEFITSRMSQFRIQAQQIIFEVTETAAISHHDRAQGLIRALRYMGCRFSLDDFGSGLSSFGYLKNLPVDFLKVDGSFVRDIATNAVDAAMVTA
IHRVGHVLGLRTIAECVESEETMHHLREIGLDFVQGYHLAKPIPLTDHLAALAS------
>tr|A4WYI1|A4WYI1_RHOS5 Plasmid pRSPA01, complete sequence OS=Rhodobacter sphaeroides (strain ATCC 17025 / ATH 2.4.3) GN=Rsph17025_3576 PE=4 SV=1
----------------------------------------------------------------------ASNARLTEAERRLADVIRGGEVGTWQFDLG
TGIILINDRWAELIGYSRSDIEPVTIFWN-RIVHPEDLARMRERHLRQFAEGHVLANEIRLRHRQGHWVWIMSRGRVTFSADGAPVLMSGVHMDISRRKA
LEDELQVERRVMETSVSAVLAFDGTNRVIFANREAEAVLGAPAEQLVGRTDPGWGISDGPVATENKVLRGLRL--------D-VQPQKGARVLSVNVAPV
EQGDSRVR-VVAAFTDVTTLAAAAEDALYQALHDPMTRLPNRVLFRECLEAAV----RHGGRLALIFIDLDNFKQINDRFGHFVGDRVILDVGRKLGAAV
PPDSTVARIGGDEFTVLVPLAA-DSIEDRVASLVREIEQPVTVEGNIFYLTASFGVSLFPDDATDADTMVRNADLAMYAAKAKGRNQCVRFDAALREQSS
QLGILGQGLQRAIRQRHLELYLQPKVALSGRPIVGAEALLRWNDPELGSISPARFIPVAESCGLIRSLDQHVTDLLCELLERWRDKGLHLP-VFVNISAE
TLASEGFADGFLGKLERLAIPPARVGIEITEGSLLGTSHVTRSNVGRLTSAGIPLSVDDFGTGYSSLGYLHRLALSELKIDRSFVAQIGTGRDAEAIVRA
VLALGRALGLRTVAEGVETGFQCDWLIREGCDQAQGFLFGPPVPVAEFERLVAG------
>tr|B8KJM0|B8KJM0_9GAMM Putative sensory box-containing diguanylate cyclase OS=gamma proteobacterium NOR5-3 GN=NOR53_701 PE=4 SV=1
--------------------------------------------------------------------------VSTDMLRRMTSILDGTNAGTWEWNAQ
SGEVRVNERWANMIGYTVEELTPISRSWS-ALVHPNDIEKVSARLDAHLRQDNHYQVSCRLRHKDGHWIWVRIRGTVLWTPDGQAEWMFGTHMDITALKE
QEDEVKRSRLIAASINAGVLSLGPDRQVEYLSPQFTKLFGYDIED---TGDTQWIDRASGNRKTMSMALSGDLVRPNNREVA-IRKSGIVRAVL------
--------------FTVSEQKRHEDLIHFRSQHDGLTGLPNRALLSERLEWAMKQARRSDWQICVAFLDLDGFKEINDTHGHKAGDAVLRATANRLKNAL
REVDTVARLGGDEFALVMTELDTESSSCLLERILHEVRQAIPYDGQELKVTASIGVTFFADSAIDGDQLLRQADKAMYDSKLSGKDCFSTFDPAQEKNLR
QINRNFEEISKALREGEFNLHYQPQVNMRTGKVVGMEALLRWKDKTGVEHPPASFLPLIRDHKLALEIGAWIISRAITDLDGWLSHGNLIP-VSINVFPK
QLVDDFFIEGIQRHLDKHPSNPALIQLEIVETAVLDEMG-VTETMVACKSLGIRCSLDDFGTGFSTLSHLKHLPVSELKIDQTFVSGMLDNKDDLAIVQS
TISLAKAFGHKVVAEGVATIEQGLLLLEMDCDVGQGYVIARPMPAEDIAEWLSQ------
>tr|M9R6X9|M9R6X9_9RHOB Putative signaling protein with diguanylate cyclase activity OS=Octadecabacter antarcticus 307 GN=OAN307_c23460 PE=4 SV=1
----------------------------------------------------------------------QLTPDIAIDSSRLRFLLEHLDQGVWNYNTM
EKSFNVADAWRRMRGIPLSEDIDTDHKWL-TEIHPEDRDMVQALFSGQVSGDDKVNSQYRHWHPDGHWMWFSCRSKVMYDDAGRPVEIVGVDTDITAMKK
NETELLKLSIAIEAAGIGVWEFDAETGLEDWDERMLGMYGITDAA---DHSDIWETHLHPDATKQYAQETFREKSDFNRDFRIVRDDGEVRHVRSLARFV
RTSKSNGR-MLGVNIDVTELERARELLEHDSRHDALTGLANRRLLDETMQALLDRI-GDEDQFAVLHIDLDHFKQINDTLGHAAGDNVLVRVSENLRGLV
GPRGLVCRIGGDEFFVLLEHFADAEVHQLCQDIIDQMAQPMFGYDQAKTFGLSLGCALGLGDVVDASEVFINADIALYVAKSDGRSCFKVFAPGLRAVTQ
IDTHAHHNLRVALTSGQIICHFQPQFDAKTHALVGAEALVRWMCPDRGLIGPDDFLPLARKTGLLPRIDDFVFGFVLEAQTKWAAAGLDVPIIALNISLE
RLQEPGLMQQI----SDRLQPHHAISFELLETTFLDTCDGLSDTLNQLRAAGVRLEMNDFGSGRSSIVALQTVRPDRVKLDRMLLAPLETNPAQIFILKA
LARVAALEGCGVVVEGIESQKQLNAVLQLDCEALQGIALARPMAEAEFAKMLIA------
>tr|V5SDC5|V5SDC5_9RHIZ Diguanylate cyclase OS=Hyphomicrobium nitrativorans NL23 GN=W911_08945 PE=4 SV=1
----------------------------------------------------------------------SRADDFEREVSSYRHMLDHFLVSKI--DAS
GRFCEANQNLLNRTGYSSDEFAR----------RVVDGAGSGLCNLEQLSDMKTWSGEYCDQGKDGQPLWVKAI-FVPRNARGELECLSTIGVDVTEQRS
AEQELKRAH-FIKHVPAAVAMFDTEMRYVAHTDHWLHDYGLKEKSLVGRSHDVFPEI--PQDKHSRILAGATE------EERFQRADGSENILRWEVRPW
YLPDQTVGGLIMLTEEITERKKMQDDLWKLVKLDSLTGLPNRLLFGETLRDAIGTADANGDLLAVTLIDIDNFKEINDTLGHEAGDELLKIVARRLEDML
GSTANIARLGGDEFAVLIGGHREDEIEVTLARVKRFLSEPVKIAGAMRFCSTSFGVTVYPRDAVEPGDLLKNADLALYRAKSVGRGHIGQFTPDLRAAIN
RRVEMQEDALEALQRGEFVLFFQPIIPADPSDPPSFEALLRWQHPVHGLLTPGFFEEVLEEPRVAAAIGVRVIDLALEQVAAWQAEGVAFGRVAVNVTSA
DFAFRCFASHLKSRLDHYNVAPERICIEVTEHVFLGSGTHVSDALQRLAELGVEIALDDFGTGYASLSHIKAYPIGRLKIDRSFVTDMEENKDSLSIVQA
IVQLARSLGLSTTAEGVEKDEQAILLRSMGCASLQGFHFSRPKPAAELGPFLKK------
>tr|N0B569|N0B569_9RHIZ PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Hyphomicrobium denitrificans 1NES1 GN=HYPDE_32348 PE=4 SV=1
----------------------------------------------------------------------NGVPGSTRQRGSYDETIEFFYVLKS--DRH
GRLIDANTKYLARIGYTLQELSK----------LPRHRLRVGHYETSSLSEMKSWSGEFCDQAKDGSLVWMSAI-VVPWDAQGNLQSLTTVGVDITDKRH
AEQALKEAN-FIKHAPAAVAMFDKEMRYVAYTDRWLADYNLGTADLTGRCHEVFPEI--PERKHQRVLAGATE------EEKFVRADGRENIIRWEVRPW
YLPDQSIGGMMMMTEEISERNKIRDKLWRLANLDVLTSLPNRLSFNELIHNEIQFSQSSNAQFAVALLDIDRLKEVNDTLGHDVGDQMLKQLASRLNDAL
SGVGKIARLGGDEFAVLIRGEDP-EITAAFDVMREALEEPLAIGGTRRNCTVSVGVTKFPNDATTAGDLLKNADLALYRAKSDGRDRVVHFVPDMRSALR
RRVELQQEARHALEAGQFILHFMPVVPIDPTKPVSFEALLRWEHPVHGLLAPGNFEEVLEDPRLAASVGSYVIEMAIRQAATWMSEGREFGRIAVNVLSA
DFSFGCLATRLQATLGRYHVPASKLCIEVTERVFLGASVNVAETMHRINALGVEVALDDFGTGYASLTHLKAFPIDRLKIDRSFVQDMHENNNSLSIVQA
IIQLGQSLGLRVTAEGVENYDQFVLLQSMGCGSFQGFYFSPPRSAEEISNFVAG------
>tr|D8JV64|D8JV64_HYPDA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Hyphomicrobium denitrificans (strain ATCC 51888 / DSM 1869 / NC
----------------------------------------------------------------------NRQL-RVGHLEPHDASIEFFYVLKW--NVA
GQLVDANERYLERIGYTLEELRK----------LPRHQIDD---ENASLSEMKSWSGEFCDQAKDGSLVWMSAI-VVPRDAEGVLQSLTTVGVDVSDKRR
AQQALKEAN-FVKHAPAAVAMFDSDMRYVAYTDRWLADYSLGTADLTGRCHDVFPEI--PERKHQRILAGAME------EEKFIRADGHENIIRWEVRPW
YLPDQSIGGMMMMTEEVSERNKIRDELWRLANLDVLTSLPNRLSFNELLFNEIQFAQLTSASFAVALLDIDRLKEVNDTLGHDVGDQMLKQLAARMKDAL
GGIGKIARLGGDEFAVLIRGQDK-EIAAAFDVIHEALEKPLAIGGTRRICTISVGVTKFPQDATTAGELLKSADLALYRAKSDGRDRVVHFVPDMRRALR
RRVELQQEARHGLESGQFILHFQPIIAADPKRPVSFEALLRWKHPVEGLLTPGLFEEVLDDPRLASSVGSYVIEMAIRQAATWMAQGKEFGRIAVNVLSA
DFTIGCLATRLQATLARYHVPASKLCIEVTERVFLGGGVNIADAMHRINALGVEVALDDFGTGYASLTHLKAFPIDRLKIDRSFVQDMHENHESLSIVKA
IVQLGQSLGLRVTAEGVEKYEQFVLLQSMGCGSFQGYYFSPPRGAEDLVNFDAG------
>tr|A0A021XH76|A0A021XH76_9RHIZ PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Shinella sp. DD12 GN=SHLA_2c001160 PE=4 SV=1
----------------------------------------------------------------------DKGSGLTKLLGAYQAALDHAIVAVT--DRR
SRILSANRQFCAVSGYREDELIG----------QPHRLVNSGHHPKAFFEGMQVWPGEICNRAKDGNLYWVDTT-IVPVGSDGRVEAYISIRYDITKRKA
AEQALHEEVGVMETVPDGIAAFDANDRLVLFNRSYANLHMHPAEAIRG---ASFESI--LQAKGQYVLPRNTG---LRARLRAHRNPGRSTVQELADGRW
IQIRSTSGHIVGTRTDITELKRSESAIKFLAEHDPLTGLLNRSVLSQRLEEAVTACRRNQTSGLLVVMDLDGFKQINDSMGHAAGDALLKTIAQRLTEAF
RRSDTVVRLGGDEFAVVVPQLGRDSIDALAQRLLAAVQRPAMVQRRSLAPRLSLGIARFPQDGHALEVLLRKADMALYRAKAEGRGTYRIFTRAMRAHVE
QRRRLTAALTSAVARGAIDVALQPQFTLSDHRLTGFEALARWTNEGRA-VSPSDFIAIAEESGLIGDLGNLVLNKALEAIGSLRQNGMETGPVAINIASA
QIRQVGFVPMLQAAVHRHGLTPGDVEIELTENILLDEAGEIARRLKTLRTAGFSIALDDFGTGYASLSHLGRFPIDRIKIDRGFVSRMSSAQDTCTIVRA
IIGLAHALGMTVVAEGIETQAQLEQLLAYGCDFGQGYLFSPPLAPEQLMARLGD------
>tr|E8RF12|E8RF12_DESPD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfobulbus propionicus (strain ATCC 33891 / DSM 2032 / 1pr3)
----------------------------------------------------------------------QREQELKRIEERYELALHASQAGLWDWNIR
TGEMYTSPDHWELLDYQSSKDDG---QPQ-RFIHPEDRDRVLAVLNEHLTGKEEYRIEYRVQEKDGEWTWFLDRGRVVRDDNNMPVRMTGTHQNITLQKH
QDQAIALVQDVIDSAGDPVMVVDLNHTLLLINQAAARLV-----------DGSIESLLFPCQVKSN-------GQPIHNPY----GNGVNNTFELEASPL
RDGQGKLYGIIEVARDITELRESQSHLYRLAHHDPLTGLPNRLLFRDRFAQAISKAERNRSGVAVLFLDLDRFKSINDTLGHDVGDALLVEVAARLQRQC
RQSDTVARLGGDEFVFILEAIHDKDASVVADKIMAALGVPVLAKGHELTITTSIGIALFPLDGATMEEVIKCADLALYAAKEIGRSNYQFYRKGMPPNGG
RPRLSGQQFRRAMANGELRLEYGPRYDLHSGRLTGLRVLPRWHHPAMGVLLPHDFVPAAEECGVLDLLNEWLLGEVCAPLQAWGELGYPCPPMTIPLGSR
QLLESGFLAALDRMLRQGRVTPAMLVIEVREPAVTEATARMIECLGRLGRLGLGCAVSDFGADRTSLARLQRLPLGSLTISDAVLADVPANPDSCILTSA
IINLGHSLGMRVVGNGIDRQSQHDFLRRHGCDQAQGPFLSPPLRAEEVPSLLAT------
>tr|E8YVE9|E8YVE9_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. CCGE1001 GN=BC1001_4532 PE=4 SV=1
--------------------------------------------------------------ITS---LKDTQAALEDSQRFFRASFENTPVGFAIVVGE
GVIVDANNAMCELLRYEKADLIGRS---FRQITVHDDPTRLSA-MPDRVKSGGRAVIEKRYTRGDGVVIQVRSHLVVTADADDQPSEAFLMVEDITERVQ
RDAALYEAQELAQVTAEGVIRTDLNGAVTLCNVAAAKLMGMEIADIVDKPLRLLEIGTA-RALPCPAVS-VLASGEIDDFVGLQASGRQRRVVTISCSPL
HAMDGKILGTVTVLQDAEKVHALTEALATQAMQDELTGLLNRRGFMRRLEQAVGGAGRHDETLCLLYVDLDRFKVVNDACGHDAGDRLLAEVAHLLSQHA
RLADTVSRLGGDEFVLLLHDVDEQAL-AVANRIVTALAYRFVHDGRLFVPGASVGLASVLAGTASAATCLAWADAACRAAKREGRDRVCVYRPDAASIVR
LTTGWSYRIQEGLENGYFKLFLQKIVSADG-EIFGYEALARFVDSSGEPVGPHMFLSAAKRFDLMTRIDQMIFNQALPLLYGLRHRGTPCPYLSVNLGAR
SIADPLFRNWLIERLSDNLDVAAMLWIEITELEEINWTEEELAFVAMVRSYGVRIYLDDFGTGYNSFDVLKRIAVDGIKIDRSVTSDIVSGPISQALVKA
AVSISADMAIDLVAEGIENHATLQFLRRLGVSKFQGYFFHRPEPAAHAIRGGRQGAAR--
>tr|U2EM62|U2EM62_9GAMM PAS sensor diguanylate cyclase protein OS=Salinisphaera shabanensis E1L3A GN=SSPSH_001651 PE=4 SV=1
--------------------------------------------------------------ITA---ERAAQDALRVSKRRLTQTLTQAPTGIALVSPQ
GRWLTVNRALCEILGYDELELLERT---FQDITHPDDLETLDY-VDDLLSGRLTGRMEKRYFHKQGHSVDVQLDVSLLRDDAGEPLYFICHIQDISESKR
TLHELFEAKELADITGEGVIRIDVNGRISELNSASVQLLGGTREQMLGEYVRFYDPDDE-VPIDDPMPR-VLGEGDVPIFTRLRRRDGEFISIVDSISPI
HDETGDVRGAVFVFQDISEARRVTQELMHEASHDPLTGLPNRRGFDEALARTWMRVQQGALHAFVMYLDLDHFKAVNDICGHAAGDELLQQIAQAMYSLL
RDSDVLARLGGDEFAAIVHAGDAGAR-VVADKIIQRVDYEFTYDGRSFEVGVSIGVAELDRGLDSTDSVLLHADTALYAAKNAGRNRYEFYQDSAAEGDV
ANLGALELLQRGLDKDEFILYLQAVVDGDG-TPVGYEALLRLSEPDGV-IRPETFLPIATRLGMMSRIDRWVLRHALHLIE--EALWPEGCYLSINISPI
SVADPLFHAELISMLDQHEVGAGRLVFEVTESEA-LFGEHYPQLIQNLRDRGFEVWLDDFAGGHTGFDILKHASVDGIKIDRAFVRNLEHEPIDRAVLRS
IADVAATLDINIIAEGVETQAARELLKRANVRQFQGYYFHRPEPVEAALVHTAALSER--
>tr|F1VZF1|F1VZF1_9BURK PAS sensor diguanylate cyclase and phosphodiesterase OS=Oxalobacteraceae bacterium IMCC9480 GN=IMCC9480_3047 PE=4 SV=1
--------------------------------------------------------------ITQ---RVHDRLALEAAQQSVTLATEAGGIGVWELNVQ
T-----GVLTCDALMYSLYGLSEGW---ARHLHPADRSRALEF-KSSLKSGAFRSEFR--VIWSDGSVHFLCSAGSLT-DAAGQVLRMVGVNWDVTPLRE
LANQLVEQHELLRVTGDAVITTDAHSQVTWLNPVAERMTGWLSGEALGRPFHIVNEETR-LPTENPVAT-CLAQGKLANHTVLISRNGDEFGIEDSAAPI
RNPSGDVLGVVLVFHDVTEQRRLSGEMSYRATHDALTGLVNRAEFETRLRRTLDKAHEESSEHALLYIDLDQFKLVNDACGHSVGDQLLQQVAKLLREAV
RARDTLARLGGDEFAVILEHCPAQAQ-RVAQQICDRMEFRFLHDERRFRIGTSIGLVPVDNRWANTAAAMQAADTSCYAAKEAGRNRVHAWFDTDQAMHH
GEMQWATRLEQALDEDRFVLYAQRIEALGEGTGLHAEVLIRLLDSDGSLIQPGAFLPAAERFHMATRIDRWVLKRAMQQIQ-------ALDTLCINLSGQ
SVGDRAFHRHAIDALTEASAVCERICLEITETAAVTNMADAAIFIEQVRALGVRVALDDFGAGASSFGYLKTLKVDLLKIDGSFIRDVIDDPLDDAAVRC
FVDVARVVGVKTVAEFVDRPEVLARVREIGIDYAQGFLLHRPEPVENLFGAAARLARV--
>tr|W6K9Z2|W6K9Z2_9PROT Chromosome, complete genome OS=Magnetospira sp. QH-2 GN=MGMAQ_3223 PE=4 SV=1
-----------------------------------------------------------------------QH---QMQKERD--QLIEMSQDFCSVTQE
GEFRLINSAFEKTLGFDRQSMMARP---IWDFIDPRDRERRDA--FEVLKKGPVNNFEIRLLTKNGGTRWTSWCGTP----DPETGLSFNIGRDITETRA
AQAALNQAARVFEHTREGILVTGADRRIQRVNKAFESITGYSEWEVIGKRPQDFI------------WREIEDTGNWTGEVWNRRCNGEVFPAWQNITAV
TDTEGTTIQYIGIFSDITEKKDNENRIQRLAHYDVLTDLPNRLLYTDRLAHALDRARRTNGLLALLFIDLDRFKNVNDSLGHQMGDLMLQTLAARLSNCL
RDSDTVARLGGDEFTVIIEDVDTEEVGITANKILAALRRPVDLRGQEAVVGASIGISLYPRDGTTAEELVKHADTAMYQAKDKGRDRTVFYTPDLTQGTE
DRFRLEGQLRNAVENGEMEVYYQPQVNMESGRLVGAEALVRWHHPTDGLVLPTRFIPLAEETGLIHSLGRWVLRTACFQGK---DKGLPV-RIAVNVSNR
QIMQGDMVRTVTQALA-DGLPASMLELEVTESFVMENPEMGVHTLNLLHDLGVWLAIDDFGTGYSSFSYLKRLPVERLKIDRSFIMDIPDDKEDEAISAA
IIAMAHELGMGVTAEGVETVEQMDFLRPHGCEESQGFLVSRPVPAPEFEVLARDLHPA--
>tr|N6YHW8|N6YHW8_9RHOO PAS domain-containing protein/PAC and GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Thauera sp. 27 GN=B447_057
--------------------------------------------------------------ALE---RRDAERRLRQSEARFRQLFEKIPNISQGYDAQ
RNVIFWNEASTALYGFSAEEALGRR---LDELLIPLEMRALEVLHRDWIEKGEIPAGELNLLRKDGSS-VPVFSSHVMQNADG-EFEMYCIDIDLTEQRQ
AQASQRLAASVFSYAREGILITDGQGLIVDANEAYCRQCGYTREEILG--AGMFQ------------RRSLSERGFWSGEIWNRRKSGEHYPALLTISAV
PDAGGEALRYVALYADIAAQKAHEAELEFLAHHDALTGLPNRALLRDRLEQAIAQARRREQRVAVAYLDLDGFKLVNDQHGHALGDRLLKQFAGGMRAAL
REGDTIARLGGDEFAAVLVDVGEGAFVPFVMRLLDVVSRPVDIDGVRLQLSASIGVSLFPQPDVDADQLLRQADQAMYQAKLAGKNRFCIFDTELDRSVR
GHHETLAQVAAGLRRGEFELFYQPKVNMRTGAVIGLEALIRWHHPQRGLLSPGAFLADVEASPLAVELGEWVIDTALAQHV---EQGLDL-PVSVNISAE
HLQRADFVARLEALLGRQDIGPGRLEIEVLETSALSNLEHVAEVIRGCRRLGVRFALDDFGTGYASLAYLKHLPADVLKIDQTFVRDMLEDPDDLAILEG
VIGLAKAFRRQAVAEGVESIVHARRLLLLGCEFAQGYGIARPMPAAAVPVWVTAWRPD--
>tr|A0A0D7K7D2|A0A0D7K7D2_9BURK Diguanylate phosphodiesterase OS=Acidovorax temperans GN=RP29_14225 PE=4 SV=1
--------------------------------------------------------------IDE---ARRARLRLSQSEERFSRIFQLMPFPMLSRCSD
GQYVEVNPAWEKLLGIPRSEALGRT---SIEIGTPADRENIR-----AAALTQLNGYEVTIHPRNAPPRTVLQSMRM--DFDGEPCWMFSV-QDITDRKR
TEEKIREREELLSLTIS-----AASLGLWDWDLQAGTVTGDSRWRALLGNPLGWTADDV-DRITAEIWRLE-----SDKPRWVRN---------LGKIVS
FDAQGTPQRMLGVAIDVTPQREQEVLLQKLAHFDALTGLPNRVLLARRLQEAMVRARQHGTLLGVAYLDLDGFKPVNDRFGHGAGDRLLMAVAGRLSLAL
RTDDCVARLGGDEFVLLLPGLESADCETRLHRVMENVAAPYPLDSERVVVTASIGYTLFPSDDADADTLLRHADQAMYAAKQAGRNRFHLFDAVQDRAVQ
LLREQAQRMRNALDEDQFTLYLQPKVDMRMGTVVGAEALVRWRHPERGVQAPGEFLPLIEGTELEIVFGQWVIEAALHKLE---ALGIEL-PMSINVGAQ
QLQQNDFATWVAQCLQRHGVPGHMVEIEITESAALYDLHAVTGTLESLRALGVAVSLDDFGTGYSSLTYLRRLPMDTLKIDQSFVHGMMNDPGDLAIVQG
VIGLARSFGYRVIAEGVETIEQGQMLLQLGCPQAQGYCIGKPMPLEDFVGWTRTWQPP--
>tr|H0C3S8|H0C3S8_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. NO-1 GN=KYG_21344 PE=4 SV=1
--------------------------------------------------------------IDE---TKRAEQRLRQSEERFSRIFHLMPYPMLSRRSD
GRYVDINAAWVEMLGIPREEALGRT---AVELGPAPVRERVA-----EVERTHLASYEVILNVRNGPPRTVLQSMRA--EFDGEPCWLFSV-HDITDRKR
SEERVREREELLSLTIS-----AASLGLWDWNLQTGEITGDTRWRAMRGIATQWTPDDM-DRITAELWRVN-----GDPARWVRN---------LGKIVG
FDAAGRPERMLGVAIDVTPQREQEVLLQRLALFDALTGLPNRVLLARKLQECMDKAHKTGKQLGVAYLDLDGFKPVNDRLGHGAGDRLLVVVAGRLTRAL
RPLDTVARLGGDVFVILMPELETDDCERLLHRVMESVSAPYTLDTERVVVTASIGYTVFPQDAADADALLRHADQAMYAAKQAGRNRFHQFDAAQERALQ
VLREQGRHLREALTASQFTLYLQPKVDMRSGAVVGAEALARWNHPERGVVPPGDFLPLLEGTELEISFGQWVVEAALTTLE---AQGLHL-PVGINIAAP
HLQHPEFSEWMARCIARHGVPAHRLEIEITESAALYDLGAVAQTLTALRAQGLVISLDDFGTGYSSLTYLRRLPMDTLKIDQSFVHGMMSDPGDLAIVQG
VIGLARSFGYRVIAEGVETVEQGQMLLQLGCAQAQGYCIARPMPLHDFIGWARSWQPP--
>tr|K0HYY0|K0HYY0_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. KKS102 GN=C380_11655 PE=4 SV=1
--------------------------------------------------------------IDE---AKRADQRLRQSEERFSRIFHLMPYPMLSHRSD
GRYMDINPAWVDMLGIPREEAIGRT---AVELGTAEDRQRME-----QVSQTHLSDYEVTLNVRNGPRRTVLQSMRA--EFDGEPCWLFSV-HDITDRKR
NEVQVREREALLSLTIS-----AASLGLWDWDLQTGLVTGDRRWRAKRGLAVQWTPDDI-DRITAELWRLN-----SEPVRWVRN---------LGKIVG
FDEQGRPARMLGVAIDVTPQREQEVMLQRLALYDALTGLPNRVLLARKLQECMAQARDTGKQLGVAYLDLDGFKPVNDRLGHGAGDRLLVVVGGRLTRAL
QPADTVARLGGDEFVILMPGLESADCERILGRVMESVSAPYTLDTERVVVTASIGYTIFPQDDADADTLLRHADQAMYAAKQAGRNRFHQFDAAQERAVQ
LLRAQGHYLREALAQAQFTLYLQPKVDMRSGTVVGAEVLSRWLHPERGLVPPGEFLPLLEGTDLEIGFGEWVAEAALTVLE---DRGMPM-PLSINIAAQ
HLQQPGFADWVAGCLARHRVPAHLVEIEITESAALYDLSAVADTLNALRAMGVTVALDDFGTGYSSLTYLRRLPMDTLKIDQSFVHGMMGDPGDLAIVQG
VIGLARSFGYRVIAEGVETVEQGQMLLQLGCLQAQGYCIARPMPLEDFIGWTPHWQPP--
>tr|J0KLV9|J0KLV9_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_03101 PE=4 SV=1
--------------------------------------------------------------IDE---AKRATERLRQSEERFSRIFQLMPFPMLSRRSD
GQYLDVNPAWETLLGIPRAEAVGRT---AVQLGTQEERQRIQ-----AFERTPQASHEVTLNGRPGTRLTVLQSMRA--DFDGEPCWLFSV-HDITDRKR
QEEQVREREELLSLTIS-----AASLGLWDWDMEHGTITGDSRWASMQGRSVRWTADDI-DRITAEVWKVP-----HEGTRWVRN---------LGKIVS
FGAGGEPLRMLGVALDVTPQREQEVLLQKLAHFDALTGLPNRVLLARRLQECLDQARERGTQLGVGYLDLDGFKPVNDRLGHGAGDRLLVMVAGRLSRAL
RPGDSVARLGGDEFVMLLPDLADAECERMLSRVMENISAPYALDTERVVVTASIGYTVFPLDEADADTLLRHADQAMYAAKQAGRNRFHQFDAAQERALV
AQREQGKHLQEAIAGAQFILHLQPKVDMRSGAVVGAEVLARWQHPERGLLPPGAFLPLLEGTELEIGFGQWVVGAALDLLR---GQGLVL-PLSINISAL
HLQHPGFADWMAQMLAGRDIDARQVEIEITESAALYDISAVAATLTRLRELGVSVALDDFGTGYSSLTYLRRLPMDTLKIDQSFVHGMMGDPGDLAIVQG
VIGLARSFGYRVIAEGVETIEQGQMLQQLGCAQAQGYCIARPMALEAFVEWAGQWQAP--
>tr|B9MJE5|B9MJE5_ACIET Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax ebreus (strain TPSY) GN=Dtpsy_1826 PE=4 SV=1
--------------------------------------------------------------IDE---PRRAAQRLRSSEERLARIFQLLPYPLFSRRED
GTYLDVNPAWEQALGYTRQEAVGRT---VVELGSAPTRAALE-----AATAEQLVGYELELTTRGGDKRTVLQSMSP--EVNGEACWLFGL-HDITERKQ
TEQRVREREELLSLTIE-----AAALGLWDWNLPSGEVTGDARWRAMYGLAVHWAPEDI-DVVTQELCEVL-----QGDGRWIRS---------VGKVVA
YDAAGQPARMVGMSIDVSSQRAQERQLERMAHYDALTGLPNRVMLERRLRAGMEHSRARGQQLGVAYLDLDGFKPVNDRLGHAAGDRLLVVVAERLKRAL
RLTDSVARLGGDEFVILLSGLAHEECERRLHTVMESVAAPYTLDGERVLVTASIGYTLYPDDEADADTLLRHADQAMYAAKQAGRNRFHGFDAAEERARQ
LRREQCGELLRALQRGELTLFLQPKVDMRLGTVVGAEALARWQHPERGLLSPVHFLHLIEGTELQMRFGEWVVDTALQQIA---AQGLEL-PVSINITPE
HLHRRGFADWMALRLAQHAVPARLLAIELTESAALYDIDHVARELTRLRALGMQISFDDFGTGYSSLAYLRRLPMDHLKLDRSFVAGMLGDAGDRAIVQG
VIGLAHSFGCGIVAEGVETVEQGLALLQMGCHHAQGYCIAMPMPVEQFMDWAKAWQAP--
>tr|A0A0A1VCU5|A0A0A1VCU5_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Acidovorax sp. MR-S7 GN=AVS7_01046 PE=4 SV=1
--------------------------------------------------------------IDE---WRRALERLRSSEERLALIFKVMPYPLFSRRED
GVYLDVNPAWEQALGFTRDEALGNT---VVGLGEAQARAKLE-----AAVRQQLVSYEVDLTTRSGEKRTVLQSMSP--DVNGEACWLFAL-HDITERKQ
AEQHVREREELLSLTIA-----AAALGLWDWDLHGGGITGDARWRAMNGLPVPWTPEDI-DAVTQALCRIL-----QGGNRWIRS---------LGKIVA
HDANGRPARMVGMSIDVTSERTQEQQLERMAHYDALTGLPNRVLLERRLREAMEQCHPRGQQLGVAYLDLDGFKPVNDRLGHAAGDRLLVIVAERLKRSL
RSCDCVARLGGDEFVILLPGLASAECEQHLRMVMDGVSAPYTLDAERVLITASIGYTVYPEDGADTDTLLRHADQAMYAAKQAGRNRFHAFDAVQERALQ
AQREQSAQLAAALERGELRLYLQPKVDMRRGTVVGAEALARWHHPERGVLAPAQFLHLIEGAELQALFGEWVVDTALAIVA---GQGLAV-PVSINITPE
HLRRSGFADWMASRLALRGVPAYLLNMELTESAALYDMDHVAYELTRLRALGMSISFDDFGTGYSSLAYLRRLPMDHLKLDRSFVAGMTTDPGDRAIVQG
VIGLARSFGYQIVAEGVETVEQGQMLLQMGCTLAQGYCIARPMPAEEFAAWAAAWHAP--
>tr|F0QD86|F0QD86_ACIAP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM 20985 / N
--------------------------------------------------------------IDE---WKRAAERLSQSEDRFMRIFELMPYPVMSRRAD
GAYLMVNEAWERLTGIPRDQALGRT---AVELGSAEGRRQLD-----TMSGRVHNALEITIHPRTGGDRTLLQSLHA--ELDGTPVWLVSA-HDITERKR
NEDLIRDREALLSLTLS-----AASLGLWDWNISTGTVTGDARWRELHGMGVHWTPADI-ENVTDALWQVAPSPSAAPAGRWVRN---------LGKIVG
YDERGRPGRMLGVSIDVTSQRVQEDMLQQLAHFDALTGLPNRVQLARRLEQAMAQARAGGWQLGVAYLDLDGFKPVNDRLGHSAGDRLLVIVAGRLTRAL
RPVDCVARLGGDEFVLLMPELQSADAEQLLRRLMENLAAPYTLGTERVTVTASVGYTLYPEDASDADTLLRHADHAMYGAKQGGRNRVQPFDAAQERARQ
TLREQAERMREALARGQFMLYLQPKVDMRSGTVVGAEALARWKHPGQGILAPGAFLHLIEGAELEAAFGEWVVDSALDLIE---AGGLEL-PVSVNISAR
HLQQPGFAQWLAGRMAQRGIPHRLLDLEITESAALYDMDHVAPQLTQLRELGITVSLDDFGTGYSSLSYLRRLPMDTLKLDRSFVHGMMSDRGDYAIVQG
VIGLARSFGYSIVAEGVETEAQGLTLMRLGCTLAQGYCISRPMPPEEFPGWVVQWRAP--
>tr|A0A099KH60|A0A099KH60_COLPS Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Colwellia psychrerythraea GN=ND2E_3857 PE=4 SV=1
--------------------------------------------------------------AIE---KIQANVNLKASDEQMQLVL-AGANLGWDWNIV
TGKVYRNERWATMLGYTHNELTTNQ---WADFVHHEDREKWQSIN-DVLEGRNSHSLEYRMLTKEGGFRWVHDQANVMQHSDGKPLRMSGIHSDITNRKI
AEEKIKLAASVFSHAGEGIIITDDKATIIDVNQAFTKITGFSREEAIG--PQILQ------------WQALKKVGYWSGEVWNRRKNGEVYAVMQTISAV
RDVNGMTTHYVSLGNDITLMKEHQYQLEHIAHYDILTNLPNRVLLADRLSQAMLQCSRYKQSLAVVFLDLDGFKHVNDTYGHDVGDELLIALSVRMKAAL
RENDSLARIGGDEFVAVLADLTTEDCEPVLERLLLAASERVVIDGIVLNISASIGVTLYPQDNGDADLLMRHADQAMYVAKESGKNRYHFFDTAQDDAVK
VQRESLEAIRNALDNRQFILHYQPKVNMKLGTVTGVEALIRWQHPERGLINPLEFLPLIENNPMSIELGEWVIDTVLTQIS---KMGPNLVSISVNIAAV
QLQQADFIDKLKTLLDAHDVEPSYLELEVLETSALEDVHHISTIMNACMALGVGFALDDFGTGYSSLTYLRRLPVSLIKIDQSFVLDMLSDADDLAIVEG
VITLAKLFKRKVIAEGVETIEHGTALLQLGCELAQGHGIARPMPASDIPSWIINWEPD--
>tr|Q47BF2|Q47BF2_DECAR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (strain RCB) GN=Daro_3099 PE=4 SV=1
------------------------------------------------------------YLI-RSKRLVGAALR-------------------------
---------------------ERASLLDSLPSADCPVYQ-------TLR-DGQRRQGEEWFFNKDGRGFPVQYSVTPI--SRQEDKEGAVVFRDISEARK
ADELMRIAAIAFETQEAMLVT-DAKSQILRVNRAFTEVTGYSAAEAIGQTPALLKSGYHEDSFYKDLWTSLKENGLWRGEIWNRRKNGEIYPEWLTISAV
RGQHGEITHFVSSFLDITKRKEAEEQIQFLALYDPLTHLPNRRLLNERLSKALTSSGRQRRHAALLFIDLDNFKMINDSMGHDIGDLLLRQVALRLRESV
RSNDTVSRLGGDEFVILLEELSPNIHDAIAQKMLDSLVQPYKFG---EHCTASIGAIPFMDATETIESLLKSADMAMYKAKAAGKNRLFFFDPAMQTEVE
ARAALERDLRQAQREKQFVLYLQPQVDQ-SGHVSGAEALIRWQHPTHGLILPGEFTHVAEETRLILPIGQWVLEEACKQLVIWQKNPDTHLTLAINVSAL
QFRNPDFVDDVARAIHESGALASRLKLEITESLLLEDIDGTIERMQVLKQLGVGLSLDDFGTGYSSLSYLKQLPLDQIKIDRSFVKDIHCNPNDAAIAEA
VIALGRSFSLNVIAEGVETIEQRDALIARGCLTFQGYLFGRPGPIDAFPACRPPQ-----
>tr|L0DXP6|L0DXP6_THIND Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Thioalkalivibrio nitratireducens (strain 
------------------------------------------------------------AWI-QNLRLREQRRR-----RLLRKITAQIPGMVYQFQM-
---LPDGTPRFRYLSAGTESVREDAEQAISPELERLLQD-------AMT-RGHSYDREFRWITAKGETIWARTICVPE--QTAGRVTRLNGFQDITDRKE
AEDALRRAAMVFENTRDGVTITDAQGSIIAVNQAFTRITGYPASEVLGKSPGLLKSDHQDNAFYRGIWRQLTETGHCQGEVTNRRRNGEIYPVLLTIDAV
PGTDGSPEFYVGVFTDLAELRESQRRADYLAHHDSLTGLANRVLLESRLTEVTERIQQHGGHAAVLLIDIDGFKHVNDSLGLSMGDRLLVRIAERLEARL
PRGHHLARTGGDEFVILMERTDRPE---MARDTLAWIREPMSLDHSRVFMTASIGISLCPEDGVDPEALLRNADSAMFKAKELGRNTFQFYTEALTHAAI
HRLSLETRLRRAVQNDEFVLHYQPQVRISDGRVVGVEALLRWQDPDIGLVFPDEFIPVAEETGLITRIGEWVLQTACRQMQEWLSNGHGPDTVAVNLSPR
QIQLNDTPALVDGILQSTGLAGRHLDLEITETALMEQGPDAARILHDLKALGVRISIDDFGTGYSSLAYLQRFPVDELKIDQSFVQKIPDTSGAAEIAAT
IIAMGRSLGLTVVAEGVETDAQLEFLRNHNCGVYQGYLASRPVPALVLQQWLTVR-----
>tr|W0DL48|W0DL48_9GAMM Diguanylate cyclase OS=Thioalkalivibrio thiocyanoxidans ARh 4 GN=THITH_06650 PE=4 SV=1
------------------------------------------------------------AWI-QNLRLREQRRR-----LLLRKTTAQIPGMVYQFQM-
---LPDGTPRFRYLSAGPESVLRDAELVVSAELERLLHD-------AMT-RGDAYDREFRWITADGETIWARTICVPE--QSAGRVTRLNGFQDITDRKE
AEDALRRSAMVFENTRDGVTITDSQAIIIAVNRAFSQITGYPASEALGKSPAILQSGYQDKAFYRHMWQQLLETGHWQGEIRNRRRDGKIYPVLLTIDAV
PGADGSPEFYVGVFTDLAELRESQRRVEYLAHHDSLTGLANRTLLESRLTRIAERIQQHGGHAAVLLIDIDGFKHVNDSLGLSMGDRLLVLVAERLKERL
PKGHDLARTGGDEFVILMASVDRPE---IAGDTLAWLREPIRLDQSRVFVTASIGISLCPEDGTDPEALLRNADSAMFKAKELGRNTFQFYTEALTQAAV
RRLSLETRLRRAVKSDEFVLHYQPQVRISDGRVVGVEALLRWQDPDLGLIPPDEFIPVAEETGLITQVGEWVLRTACRQMRQWLADRNGPDTVAVNLSPR
QFQLQDMPALVGSILQSTGLAGRHLDLEITETALMEQGPDAARILHDLKALGVRISIDDFGTGYSSLAYLQQFPVDKLKIDQSFVQKIPDTLGAAEIAAT
IIAMGRNLGLGVVAEGVETAAQLEFLRNQDCGFYQGYLANRPVRAQELREWLAAR-----
>tr|B8GLY5|B8GLY5_THISH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) GN=Tgr7_0645 P
------------------------------------------------------------ALF-RGQRLN--RRL-----LLQSRVEMRTEH--------
-------------LNVAVEQRRQAEAEVLAIRRAFDQT---------------LYH-------RDGRVLVVDYAFRPI--LEGGQVRGGVFCRDITGRKR
IEESLRLHAQVFDTATEGVMIADARGRILSVNRAFEQVTGYSAEEVVGRNPSILSSGRQDKAFYRRMWDTIKGEGIWSGEIWNRRKDGEIYPEWLTISSI
AGPNGEASHFVAVFSDITAQKRSEQEIDFLANHDPLTGLANRNLFEDRLAHAISMAGRNGQHVGLLLVDLDRFRLINDGMGHGPGDALLRETGRRLGHCV
RDSDTVARLGGDEFGIILEGLADAA---QAERILEAMRAPLRLGGQELFCTVSIGIAVFPADGTDAATLLRHADTAMALAKREGRNNFQFYTHALTEAVF
SRLNIETGLRHALERDELRLHYQPILDAASGRIAAMESLMRWQHPERGLVSPGVFIPVAEQSDLILALGRWALVSACAQVRAWSDAGLEPVPVSVNIPAC
HFRQPGFVEEVLGVVRETGVQPQSLIIELTESALMEPVSLAEERIRRLRDTGVVVAIDDFGTGYSSLGYLQRFHVNYLKVDRSFVSGLPGDENARAITEA
VIGVSHSLGLQVVAEGVETQAQLDHLRATGCDKVQGYLTGRPVTAEVAATLLP-G-----
>tr|N6YJH9|N6YJH9_9RHOO PAS domain-containing protein/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Thauera sp. 27 GN=B447_03833 PE=4 
--------------------------------------------------------------L---ARLTQRNAQ-------------------------
---------------------RKASALAEQARAQAALDQ-------HLRGESPFYEQDLRLRHCAGHWIWVHDRGHVVQRSLHGAPLLLTGQLDISARKQ
DEERLRLAASVFASCYEAILITDANNCIIDINPAFTRITGYSREEVLGRNPAVLGSGRQGREFYRNMWASLEENDHWQGELWNLRKDGSDFAEMLSISRV
RDENGRLMHHVGLFSDISHLKLHEEELNRIAYFDPLTGAPNRRLLDDRLRQAIAHAHRTGKTLGVCVIDLDGFKPVNDRYGHEAGDRLLVEIVDRLNGLL
RASDTVARLGGDEFVLLLEDVDG-----VLKRILDTIRQPIQIEQDWVCVSASIGVTLFPEDDADPDTLLRHADQAMYRAKQRGRNCIQHFDTSIEQGLA
ERRARHARLAEALRDGELLLLFQPQVDMQSARMVGAEALLRWRHPTRGMLSPAQFLADAEGSELEIDIGKWVLDQALAALARWREAGLDSV--SINVSAN
QLQQAGFVDSVRAALACQSLTAAMLKLEILESAALDDMTSALEVLRACRGLGVRLALDDFGTGYASLKHFRQLPVDQLKIDHSFVIDMLDDAEDRAIVEG
VIQLASAFGREAIAEGVETPAHAAALAALGCRLGQGFGIARPMPAEHVMGWVSWY-----
>tr|A0A0C3MKT5|A0A0C3MKT5_9RHOO Thauera sp. SWB20 PO78.SWB_20._Contig50, whole genome shotgun sequence OS=Thauera sp. SWB20 GN=PO78_1358 PE=4 SV=1
--------------------------------------------------------------L---VRLAQRNLA-------------------------
---------------------AAARRLAAEAEAERELDR-------HIRGETAFYEHDLRLRHCDGRWIWVYDRALAVRRDADGRALLLTGQIDIDRRKE
NEERLRLAASVFSSSYEAILITDVDNRIVDVNPAFCRITGYSREESLGRDPGMLASGRQGREFYRAMWQAIEEHDHWQGELWNRRKDGSEFAEVLSISRV
RDARGRVIHHLAMFSDISRLKKHEEELNRIAYFDPLTGAPNRRLLDDRLRQAIAHSRRTGKPLAVCVIDLDGFKPVNDQLGHEAGDQVLIGIVDRLGAIL
RASDTVARLGGDEFVLLLEDIEG-----VLERVLEAIRTPIALASQQVCVSASIGVTLFPEDDADPDTLLRHADQAMYRAKQRGRNCIQFFDASVEEQQR
VRKERLERLDQALRRQEFVLHFQPQADMVDGRPLGMEALLRWQHPERGLLAPGEFLPDLEGTELETRLGQWVVDHALGALEHCRAAGLDGV--SVNVGPG
PLMQAGFVASVRSALERHDIPPERLELEILESTALDDMVLAMDVLEACHRLGVRIALDDFGTGYASLRHFRQLPFDRLKIDRSFVLDMLEDGEARAIVGA
VVQLARTFGREVIAEGVETPAHAAALLALGCRLGQGFGIARPMPVEHIPGWVSWQ-----
>tr|T0AVT3|T0AVT3_9RHOO Uncharacterized protein OS=Thauera terpenica 58Eu GN=M622_09650 PE=4 SV=1
--------------------------------------------------------------A---LGLARGNRQ-------------------------
---------------------RRARALAATASSNALVAR-------HLKGELTDYRIEVRMRHKAGHWIWVYDCGRLVSRTPSGEPLLMVGHQDISERKL
AEEMLRLSASVFTNSYDAIMITDSTNHIVDVNPAFTRITGYRREEALGRKPSLLNSGRHEHEFYAQMWRSLNERGHWRGEVWNRRKNGEIFAESLSITCV
KDEHGQLIHHVAVFSDISRLKAHADELDRIAHFDPLTGVPNRRLLDDRLKHAIARAERSGQTLAVCMLDLDGFKPINDQFGHEAGDHLLVQIVSRLQSML
RKVDTVARLGGDEFVLLLGDLES-----VFERILDEVRKPVRLRGEDVSVSASVGVTLYPEDHSDADTLLRHADQAMYLAKQRGRDCVQLFDAGVELSLQ
AKQELLRRLAQALEAREFVLHYQPKVDMLQGRPIGVEALVRWQHPERGMLAPGEFLPTIEGSELEVELGEWVIRSALQQIDSWRALGLDPV--AVNVSAR
HLLRPGFVRSLRDALAQHAIAPDRLEIEIIESTAITDMHSALEVLTACRALGVRLALDDFGTGYASLAYFRRLPVDLLKIDHSFVRDMLTDADDRAIVLS
VVHLAQSFGREVIAEGVETMEHAQALIDIGCHLGQGFGIARPMPPTHIPGWMSWY-----
>tr|N6Y4T9|N6Y4T9_9RHOO PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Thauera sp. 63 GN=C664_12410 PE=4 SV=1
--------------------------------------------------------------A---IGLARRNRQ-------------------------
---------------------RQARHLAVAIAIKRKLRA-------HFAGEVPGFRHDIRMRHKDGHWVWIHSCGSVITSARDGSPQLMAGHEDITERKQ
SEDALRLSASVFQNSYEAILITDADNRIVDVNPSFTRITGYAREEVLGQNPSILSSGKQSRDFYTQLWRSLQTTDHWRGEVWNRRKNGELFAESLSITRV
LDDNGRLVHHVAVFSDVSRLKAHAEELDRIAHFDPLTGVPNRRLLEDRLRQAIAHADRSRRPLAVCLLDLDGFKPINDQYGHEAGDQLLVEIVDRLQTML
RSVDTIARLGGDEFVILLGDLDS-----VFDRILEAVSEPVQLRDDSVAVSASIGVALYPDDRVDADTLLRHADQAMYLAKQRGRNCVQVFDSSVEASLR
QKQELLRRLAQALEQGEFVLHFQPKVDMFERRPVGAEALVRWNHPEVGLRPPADFLPALEGNELEITLGEWVIRTALEQVANWRAAGLDPV--AVNISAR
HLLKANFVADLKAMLDEHDIAPDRLELEIVESTAITDMNAALDVLTACRALGVRLALDDFGTGYASLAYFRRLPVDLLKIDRSFVRDMLSDADDRAIVLS
VVHLAQAFDRQVIAEGVETMDHAEALIEIGCRLGQGYGIARPMPAAHVPGWIVWY-----
>tr|G0A5C0|G0A5C0_METMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylomonas methanica (strain MC09) GN=Metme_3254 PE=4 SV=1
------------------------------------------------------------LLI-VKRKLVLQQKLLLESETFLRTLIRTLPDLIWLKNAE
GVYLACNPRFEGFFGAEDYDFVDRELADSFLGDGHREL--------------------------------LETRKIPM-RNAAGEFVGVLGGHDITKRKQ
AEEKLLLAASVFTHAREGILITGVDGKIIDVNDTFTAITGYSREEVLNRNPRMLKSDRQSRAFYTAMWADLNEKGEWSGELWNRRKNGQLYAEILTISAV
RDAQGNTQHYVALFSDITPFKEYEQQLERIAHYDALTSLPNRILLADRLRLAMTQAQRRGMKVAVVFLDLDGFKAVNDTYGHDMGDELLMTLASRMKQAL
RESDTLARLGGDEFVAVLVDLPDTE---LLSRLLTAASQPVVFGELNMLVSASLGVSFYPQAEIDADQLLRQADQAMYQAKLTGKNRYHLFDADRDGSVR
SLYESLEHIARALENREFVLHYQPKVNMRTAEVLGVEALIRWQHPEKGLLSPASFLPVVENHPLAIEIGEWVIETALGQLEEWQTAGLDPV--SVNVGAR
QLQRAGFVKRLQSMLAAHTIRPGHLEIEMQENSALEDIGAVSQVMHACRDIGIQFTLDDFGTGYSSLTYLKHLPVCSLKIDQSFVRDMLDDADDLAILRG
VIGLADTFKLGVIAEGVENRAQADSLLQLGCELAQGYGIAPPMPPGELPGWAASW-----
>tr|W6EMW2|W6EMW2_SULMU Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Sulfurospirillum multivorans DSM 12446 GN
------------------------------------------------------------LMS-VGFQLYRQNKRLLLVQDNLQSTLDAIPDALFEMSLD
GVYFRVGRAHANVSASLVYEIYPKDVADIFFELSVSKK------------------------------------------KESHEVAHFIVSHEITHRKE
AEAKLKLAASVFTYAREGIMITNASGEIVEVNDTFTCITGYEHQEVVGQNPRLLKSGRQSESFYKQMWQSLLEKGHWYGEISNRRKSGEVYVQMTSISAI
YDEHEVVQSYVALFTDITTMKEHEKQLEYVAHYDALTSLPNRVLFADRLRQAMAQTERRKKELAVVYLDLDGFKVINDQYGHHVGDELLVIIAERMQEAL
RQGDTISRLGGDEFVAVLTDLSNQD---ILDRLLKATSDPIVIDKNIIQVSSSIGVTLYPKDGVDADQLLRHADLAMYQSKQSGKNRYHFFDVESDRAIK
KHNESLESILSAIINDEFLLYYQPKVNLETRELVSVEALIRWQHPEKGFLLPHAFLPIVEDHVLSIRLGEWVIERAFKQMSAWIKEGLSSV--SINVGAR
QLQDSSFTEYLQTMLLRYDVPAHLVELEILETSALEDMVHVSQIMHACKSLGVRFALDDFGTGYSSLSYLRKLPIDILKIDQSFICNLLHDNDDLAIVEA
IVGLSKAFDLHVIAEGVETQEHAELLLKHGCELAQGFGIARPMHPDAIIAWKDSS-----
>tr|A0A099KC73|A0A099KC73_COLPS Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Colwellia psychrerythraea GN=ND2E_4175 PE=4 SV=1
------------------------------------------------------------LII-IGLRLIIQNRFLLSVQDNLNSTLNAIPDSMFELGLD
GTYYRIWTPDSNFLLAEISDVMEPEAAKTCAITLSSIRE-------FLNHKTKKYIAEFRMKHKDGQYINILSRAFAS-ENEAGEITRLVGHVDITQQTL
SEEKLKLAASVFTHAGESIAITDAEGIILDVNDTFTHTTGYSREEAIGNNPRILQSGRQSHQFYVEMWQALLNEGYWSGEVWNRRKNGEVYAVMTTISAV
RDVHGVTTHYVSLANDITTIKKHQEQLQRVAHFDLLTNLPNRVLLADRLNQAMLQCGRHEQSLAVLFLDLDGFKAVNDSYGHDVGDDLLIVLSLRMKEAL
RENDTLSRIGGDEFIAVLADLDKVE---VLERLLQAASKSVNIGNVVLNVSASIGVTIYPQDNVDAEQLIRHADQAMYVAKQSGKNRYHLFDTAQDDAIK
VQRESLEAIRSALDNQQFILHYQPKVNMKTGKVIGAEALIRWQHPTRGLLNPMEFLPAIENHAMMIEMGEWVIDSVLSQISQWQKMGLTPISASVNIAAV
QLQQSDFTQRLIRQLADHEVDPCRLELEILETSALEDVHHVSTIMNDCMELGVNFALDDFGTGYSSLT--------------------------------
------------------------------------------------------------
>tr|I1D7K7|I1D7K7_9PSEU PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Saccharomonospora glauca K62 GN=SacglDRAFT_04096 PE=4
--------------------------------------------------------------ITA---QKAAEAALRYQ----AALVSHVSDAIIGTTSD
GMVTSWNPAAERIYGHSENIALGKP---VGE-LVGAPLDPE-A----VVAEGGV--IEAEHRKADGSALTVRVSASPMDR------GYVLVCADETARRT
AERRYR---TVVAALDEGVVVTDANGFVDSANPAAGRILGLPVEAMLGCSPTLFPLYDESGARIPP-SEYPLAATRTTGVVRARRPDGRWVWLSMSCRPL
NPNSAPPHQVVTSFTDITERKAIGEQLEHDATHDPLTNLANRTLVLQRLEEALRRRE-GRSPACVLFIDLDKFKVINDSLGHGIGDKVLRIAGQRLKNCV
RHHDVVGRLGGDEFAVVTFGVEHKQIQALIDHIRKALTEPITVEGRRLRVDASIGVVTAREDERSAEDLLRDADVAMYQAKTRGRGRHEFFDVELRERVQ
RQLRLEQDLRDSVRSGQLWVAYQPVVDLRTCQRVAVEGLLRWNHPAHGPISPSEFIPLAEESDLINLVGGHMLRTATRELARRRLREGVRTSLTVNLSAR
QLDDESVVDTVSDALRSTGLPPDELCLEITESALMLDPATAADVLTALRGLGVRLAIDDFGTGYSSLAQLWKLPLDTLKIDRSFVAGLDGPADAEAIIKG
IVTMAHSIGLTVIAEGTENERQVAILRELGCDQAQGFHFGKPAPADEVFG----------
>tr|I0V399|I0V399_9PSEU PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Saccharomonospora xinjiangensis XJ-54 GN=SacxiDRAFT_2
--------------------------------------------------------------ITA---QKAVETALRYQ----AALVRHVSDAIIATTPD
GMVTSWNPAAERVYGHSEDLALGKP---VGE-LVGATLDPE-A----VVGQGGV--VEAEHRRADGSVLTVRVSASPMES------GYVLVCADETARRA
AERRYR---TVVTALDEGVVVIDGCGFVSSANPAAGRILGLPVETMIGCSPTLFPLADESGARIPP-SEYPSALTRTTGVVRARRPDGRWVWLSMSCRPL
DGNASPPHQVVTSFTDITERKAIGERLEHDATHDPLTNLANRTLVLQRLAEALRQPH-GRSRACVLFIDLDKFKVINDSLGHGIGDKVLRIAGRRLKNCV
RRNDLVGRLGGDEFAVVTFGVEHKQIQALIDHIRKALTEPINVEGRRLRIDASIGVVTAQEDERSAEDLLRDADVAMYQAKTRGRGRHEFFDVELRERVQ
RQLRLEQDLRESVRGGQLWVAYQPVVDLRTYQRVAVEGLLRWQHPTHGPISPAEFIPLAEESDLITLIGGHMMRTATREMAKWQLRCGTRTRLTVNLSAR
QLEDDSVVAAVNDALRSTGFPPGELCLEITESALMRDPEAAADVLTSLRDLGVRLAIDDFGTGYSSLAQLWKLPLDTLKIDRSFVAGLDSGTDAEAIIKG
IVTMAHSMGLTVIAEGTENERQVAILRELGCDQAQGFHFGRPAPADDVFG----------
>tr|H0JZM5|H0JZM5_9PSEU PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Saccharomonospora azurea SZMC 14600 GN=SZMC14600_0104
--------------------------------------------------------------ITA---QKAAESALRYQ----AALVSHVSDAIIGTSSD
GMVTSWNPAAERVYGHSEDVALGRS---VGE-VVGATLDPQ-A----VVAQGGV--IEAEHRKADGSALTVRVSASPMDT------GYVLVCADETARRA
AERRYR---TVVAALDEGVVVLDANGLVGSANPAAGRILGLPVEAMIGCSPTLFPLHDESGARIPP-SEYPSSLVRTTGVVRARRPDGCWVWLSMSCRPL
DSNATPPHQVVTSFTDITERKAIGERLEHDATHDPLTGLANRTLVLQRLSEALHRRR-DGSLACVLFIDLDKFKVINDSLGHGIGDKVLRIAGQRLKNSV
RRNDLVGRLGGDEFAVVTLGVEHKQIRALIHHIRDALTEPITVDGRRLRVDASIGVVTAGEDERSAEDLLRDADVAMYQAKTRGRGRHEFFDVELRERVQ
RQLRLEQDLRDSVRAGQLWVAYQPVVDLRTYQRVAVEGLLRWQHPVHGLISPGEFIPLAEESDLINLVGGHMLRTATRELARRRLRGDVRTRLTVNLSAR
QLEDDSVVDAVHDALRSTGLPPAELCLEITESALMRDPEAAADVLTALRGLGVRLAIDDFGTGYSSLAQLWKLPLDTLKIDRSFVMGLDGSADAEAIIKG
IVTMAHSMGLPVIAEGTENERQVAILRGLGCDQAQGYHFGRPAPADEVFR----------
>tr|C7MR68|C7MR68_SACVD PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Saccharomonospora viridis (strain ATCC 15386 / DSM 43
--------------------------------------------------------------ITA---QKAAQAALRYQ----AALVRHASDAIIATTSD
GMVTSWNPAAETVYGHSEDQALGRP---VSE-LVGVTLDPA-T----IVAEGGV--VEAEHRKADGSALTVRVSASPMDD------GYVLMCADETARRT
VERRYR---TVVTALDEGVVVIDENELVGSANPAAGRILGLPVEAMIGCSPALFPLYDESGARVPP-SEYPSALTRRTGVLRARRPDGQWVWLSMSCRPL
DSDKTPPHEVVVSFTDITERRAIGERLEHDATHDPLTNLANRTLILQRLEEMLRR-S-GGRPVCVLFIDLDKFKVINDSLGHGIGDEVLRIAGERLKNCV
RQGDLVGRLGGDEFAIVASDMAHSQIQALIGRIRRALTEPVVVEGRRLRIDASIGVVTTHADERSAEDLLRDADVAMYQAKTRGRGRYEFFDVELRERVQ
RQLRLEQDLRESVRGGQLWVAYQPVVDLRTQQRVAVEGLLRWDHPVHGRISPGEFIPLAEESDLINLIGGHMLRTATRELASRRRHSGVRTQLAVNVSAR
QLDDGSVVSAVNEALRATGLPPGELCLEITESALMQEPEAAADVLTALRDLGVRLAIDDFGTGYSSLAQLWKLPLDTLKIDRSFVAGLDGPPDAEAIIKG
IITMAHSMGLTVVAEGTENERQIAILRELGCDQAQGFHLGKPAPAHEVFG----------
>tr|H5X458|H5X458_9PSEU PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Saccharomonospora marina XMU15 GN=SacmaDRAFT_5165 PE=
--------------------------------------------------------------ITA---QKSAEAALHYQ----AALVSHVSDAIIATTAD
GVVTSWNPAAEAVYGHSSRSAIGRP---VGE-VVGSGLDPA-A----VLTDGGV--VEDTHRRADGSMLAIRVSAAKMNT------GYVLVCADETARRQ
AERRYS---TVVAALDEGVVVIGADGLVESANPAAGRILGLPLHAMIGCSTTLFPLYDESGQRIDP-TDYPSAQSQRTGVVRAQRPDGRCVWLSMSCRPL
DGSPTTPAAVVTSFTDITERRAIGERLEHDATHDPLTGLANRTLVLQRLASALREGG-RGGMACVLFIDLDKFKVINDSLGHNIGDKVLRIAGQRLQHSV
RRSDLVGRLGGDEFAVVTFEVRHGEIRSLIEHLRHSLTEPITVDGRRLRIDASIGIVTAGPDERSAEDLIRDADVAMYQAKTRGRGRDEFFDVELRERIQ
RQLRLEQDLRDAIRGGQLWVAYQPVVDLRTYRTVAVEGLLRWDHPVHGSISPGEFIPLAEESDLINLIGGHMLRTATRELATRRGPGKIDTRLTVNLSAR
QLDDEKLVDAVAEALRATGLPPEELCLEITESALMREPKAAAEVLTALRGLGVRLAIDDFGTGYSSLAQLWKLPLDTLKIDRSFVAGLDEPTDAEAIIKG
IVTMAHAMGLTVIAEGTENARQVEILRDLGCDQAQGFHFGRPSRAADIFP----------
>tr|M2PIV3|M2PIV3_9PSEU Diguanylate cyclase OS=Amycolatopsis azurea DSM 43854 GN=C791_5984 PE=4 SV=1
--------------------------------------------------------------ISA---QKAAEATLRYQ----AALISHVSDAIIATNGT
GMVTSWNPAAENVYGWTAGEAIGGT---VSD-LVGAALDPE-T----VLRKGGV--LRTTHRHRNGSTLAIRISAAEMND------GFVLVCADETARRR
AEQHYS---TVVASLDEGVVVVGPGGLIESANPAACRIIGIEHDDLIGVPCVTLELYDEQG-RIPP-ARIPSVVTRRTRVLRLRRPAGDDVWISLTSRLL
TPEDPSAMAVVTSFTDITERRAIGERLAHEATHDPLTELANRTLVLDSLAEALSGAG-RAELTTLLFIDLDKFKVINDSLGHSVGDKVLRIAAERLRRCI
GESDLVGRLGGDEFVVVTAEITEDEIKALAEHLREALTEPITVNGRQLHIDASIGIVTAANDTRTAEDLLRDADVAMYQAKTLGRARYEFFDVELRERMQ
RRLRMEQDLRDALQNEELWTAYQPVVDIESGEMVAVEALLRWKHPAHGTISPAEFIPLAEESDLINLIGKYVLRTTTREIARRRRQLGIDLNLKVNLSAR
QLDDPHLVAGVQDALKTTGLPPHALTLEVTESALMRDQAAAAEVLTSLRDLGVTLAIDDFGTGYSSLAQLQRLPLDTLKIDRTFVTGIAESRDAAAIVKS
IIAMAHAVDLIVVAEGVEDEEQLAVLRELRCDQAQGFHLGRPAPPDELFG----------
>tr|T2RTC4|T2RTC4_SACER Histidine kinase OS=Saccharopolyspora erythraea D GN=N599_30195 PE=4 SV=1
--------------------------------------------------------------VSA---QKTAEETLRFQ----AALVQHVSNAIIATDRS
GIVTSWNPAAEAVYGIAEEEALARH---VAD-LVGAPLQPE-E----LVSSGGV--TEALHRRSDGAALVIRISAAEMDS------GFVLVCADETARRR
AEQDFA---TVVAALDEGVVVVGRSGVIESANPASQRILGAPASQIIGTRPTSWPTFDESGAAMRP-EEQPSSLAQWTGMVRLVRPDGRSVWLSLTSRSL
TPQDRPPHMVVTSFTDITDSRAARERLEYEATHDPLTGLANRTLALRHLAVS---RD-RTRAIAVLFIDLDNFKLINDSLGHGVGDDVLRIVGERLFRTS
REEDLVGRLGGDEFVVLVHDESDDVLRELATGLLAALTEPIHVQGRQLHVNGSIGIVLSRPDTRAGPELLRDADVAMYQAKTRGGGRYEFFDVELRESMQ
RSMVLEQDLRHAVQQDQLWVAYQRVVDLRDERTVGVEGLLRWTHPVHGTVSPGEFIPLAEQSDLINSIGAHMLRMATRQVAAERERGGEGLRLNANLSPR
QLDDPYLQVLVKQALTDAGLPAHALCLEVTENAIMHDPAASARVLSSLRELGVRLAIDDFGTGYSSLAQLRRLPLDTLKIDRSFVTDLDSSEELRVMINS
IVAMAHAVGLDVVAEGVETARQLDLLGEVGCDQAQGFYLGRPGPIERLRD----------
>tr|R1HQ71|R1HQ71_9PSEU Signal transduction protein containing EAL, PAS and GGDEF domain OS=Amycolatopsis vancoresmycina DSM 44592 GN=H480_25162 PE=4 S
--------------------------------------------------------------ITA---KKAAADALRYQ----AALVSHVSDALIATTGE
GVVTSWNPAAEAVYGWTAAEAVGRR---ASE-LIGAPLDLP-A-----IRGGGV--AEAVHRRRDGAPLAVRVSAAEMND------GYVLVCADETARRR
AEQNYR---TVVASLDEGVLVMGPAGLIEAANPAACRILGVAEADLVGVPCHTLVLFTESGQWIPP-DELPSVQTRRTGVVRLRRPDGRDVWVSLTSRLL
NPDDPAAMAVVTSFTDITETRAISAQLAHDATHDPLTRLANRTLVLGRLDVR----E-RG-AVTVLFLDLDKFKVINDSLGHSVGDQVLRIVGERLRRSS
GRDDLVGRLGGDEFVVVTAEVTDGEVRALAEHLRAALAEPIGVLGRQLHLDASIGVVLVGHDRRSAEDLLRDADVAMYQAKTLGRARHHFFDVGLRERMQ
RRLRMEQDLRDAVHDGQLWPAYQPVVDLRSGEMVAVEALLRWTHPRHGAISPAEFIPLAEESDLINVIGKEMLRATTRELAARRIRQGLDLTLKVNLSTR
QLDDPHLVPAVQDALASTGLPAGALCLEVTESALMRDQEAAGEVLASLRSLGVLLAIDDFGTGYSSLAQLRRLTLDTLKIDRSFITGIAESRDAEAIVTS
IIAMAHAVDLTVIAEGVESAEQVDLLRALGCDQAQGYHLGRPVPAAELFG----------
>tr|D9V0E4|D9V0E4_9ACTO Putative uncharacterized protein OS=Streptomyces sp. AA4 GN=SSMG_00128 PE=4 SV=1
--------------------------------------------------------------STV---KHAAAAAVRAQ----EALVTHVSDAIVTITGE
GIVTGWNPAAETVYGWPAPEALGRR---VHE-VLGIDPDPA-S-----IR-DGV--AQQTHRGRDGSPRQVRVSATETVD------GFLLVCTDETARRR
VEQHYA---TVVAALDEGVLVIGPTGLIQSANPSACRILGVPEPELLGVSCTTLVLFDEDGNRIPD-DELPSMHTRRTGVVRLRRPDGRDVWVSLTSRLL
DSDDPNGVSVVTSFTDITERRAISARLAHEATHDPLTRLANRTLVLDRLDRR----D-GAESAAVLFLDLDKFKLINDSLGHPVGDQVLRIAGERLRRAT
GPDDVVGRLGGDEFVVVTSATTGAQVGVFAAHLRSVLSEPVSVHGRQLHLDASMGIVLVEPDRRTAEDLLRDADVAMYQAKSRGRGRFEFFDVALRERMQ
RRLRMEQDLRDAVHSGQLWPAYQPVVDLRTGEMVGVEALLRWTHPKHGAISPAEFIPLAEESELINVLGKYVLRDTTRELAALRTGRGLDLSLKVNLSVR
QLDDPHLVPAVRDALATTGLPPGSLTLEVTESALMRDTSAAAEVLSALRSLGVLLAIDDFGTGYSSLAQLRRLTLDTLKIDRSFITGIADSRDAAAIVTS
IIAMAHAVDLTVVAEGVETAEELALLRELGCDQAQGYHLGRPLAAAELFQ----------
>tr|M2QDD5|M2QDD5_9PSEU Diguanylate cyclase OS=Amycolatopsis azurea DSM 43854 GN=C791_6443 PE=4 SV=1
--------------------------------------------------------------LTM---QKAAEAGLRFQ----AALVGHASDAIIATSPD
GLVTSWNPAAEAVYGHELDQVIGVP---VAE-VVGAPMSPR-Q----VVAAGGV--VQATHFSADGTALAVRVSAAEMFD------GYVLLCADETAQRR
AEAEFA---TVVETLDEGVLVVGPSGRIDLANSAAHRISGVPEGSLVGLESRTLRLHDESGAPVPV-EDLPSARVRRSGVVQVRRRDGAHRWLSLTSGPL
MAPGQSVPSVLTSFADITERRAISERLAYEATHDPLTRLANRTLALDRLRRTIAD---PARTATVMFIDLDKFKIINDSLGHTVGDQVLRIIGDRLRAAA
GPSDLVGRLGGDEFLVITTGYTEAEVRALADHLQRHLAESLTVHGRELHINTSIGIVIAEPDSRSADELLEDADLAMYQAKTFGPGRYAFYEPGMRKRVR
DRFALEQDLRNAVADGLVETVYQPVVDLRTGEMVAVKAKSRWEHPVRGSIDPAELAEIADDGDLLTIIGAKVLAKAAGEISRWRADHGVHCNVNVSLSVR
QLGDPTLLQVVQTTLEEAGLGPRDLSLDVDETALKD----ASDAVDALRKTGVRVTAERFGAGYSSLAQLCRLDLNVIEIDRSFVADLGLSSDAEPIVAG
IMAMAHAVDLVVVAEGVETAQQLKVLHDLGCDWAKGPLVAPPGPLAELKS----------
>tr|H5U7T3|H5U7T3_9ACTO Putative response regulator receiver protein OS=Gordonia terrae NBRC 100016 GN=GOTRE_001_00380 PE=4 SV=1
--------------------------------------------------------------ITA---QKAVESALRRQ----AALLDHVSNAVIAVDDQ
MTVRSWNPAAEQMYGRGAADAIGRN---LDE-VVGAHVDPH-A----AVSLGGT--VDELHRRSDGRSFLAHTSVTTMDD------GFLVVA--EPTRRP
LIERLG---TILAALHQAVIVVREDGDIELANPAAGTMLGPE--AIPGASVHQVPLDFV------G-DESPISRCLRTRTATITTPTG-ERWLSCSCRPI
DDDG-TDVVVLVSFVDITDRYRERTQLAWEAVHDPLTGLYNRSGIIRELESHMARLEADACCVAIFYIDLDNFKLVNDSLGHAVGDEVLHAVAQRLAAAT
PDEAAVGRIGGDEFVLVATLGISEEIEQQIDDIRGTVYEPITVSTRSEPVEASIGVATVKADEYTATDLLRDADIALYQARKASRARYVRFQTQHREELQ
RRQRIEEELRRVLDTEQLEIHYQPIVSTGDGTLVGLESLLRWRHPELGSISPTEFIPLAEGSNLIDRVGNYVLETATAEVAAIPELRR--VMLCINVSRR
ELTNGQFPERLRDTMTRSGMDPTAFCLEITESALDPLDGDLLTLLGNVRELGTQVSLDDFGTGASSLSEFYRLPVSVLKTAKSFVDALEEHPSAKSILAG
IVTMAHAAGMRVVAEGVETESQAAIVAEVGCDLAQGYHYGRPAPLAEVIA----------
>tr|L7KUT0|L7KUT0_9ACTO Uncharacterized protein OS=Gordonia amicalis NBRC 100051 = JCM 11271 GN=GOAMI_13_01600 PE=4 SV=1
--------------------------------------------------------------ITA---QKAIEVALRRQ----AALLDHVSNAVIAVDRN
MTVRSWNPAAEQMYGITADKALGRE---LDS-VIGGTLDIK-A----AMALGGT--VDQLHRRADDRTFLAHISVTSMDD------GFLIVA--EATRRP
LIERLG---TILAALHQAVIVVREDGRIELANPAAATMLGPQ--SAPGSLVHDLPLDFV------D-GESPVVRCLRTGTATINTPGG-ERWLSCSCRPI
DDDT-SDAVALVSFADITERYRERTRLAWDAVHDPLTQLYNRAGILKELEAHMDALAEDSGCVAIYYIDLDNFKLVNDSLGHAVGDEVLHAVAQRLAAAT
PPEGAVGRIGGDEFVLVATHTKTAEIDRQIESVRAAIRPPVRVSIRSEPVRVSIGVATVAAERYTPTDLLRDADIALYQARKASREPYVQFRTQHREELQ
RRQRIEEELRRALDRSQLEIHYQPIVSTDSGTLVALEALLRWNHPDLGSIPPAEFIPLAEQSTLIDKVGAHVLATACAEVAATPELAQ--IMLCINASRR
ELTNGEFLHRLTATCEQTGMNPRSLCLEITESALAPLDGGLLNLLREIRALGIHISLDDFGTGASSLSELYRLPVSILKAARAFVDALEERPSARTILAG
IVDVAHAMGVRVIAEGVETAEQAATIAAVRCDLAQGYHYGRPKPLAEIVT----------
>tr|R7YA08|R7YA08_9ACTO Putative signal transduction protein OS=Gordonia terrae C-6 GN=GTC6_10761 PE=4 SV=1
--------------------------------------------------------------VSA---HKAVESALRRH----AILLEHVSNAVVAVDDQ
LTVLSWNPAAERMYGRRASEAIGRN---LDD-VVGVHVDLQ-T----AVSLGRA--VDQHHRRHDGRSFPTRTSVTTMDD------GFLVVV--EPTHRS
FVERLG---VVLDALHQAVIVVREDGDIELANPAAATLLGQE--AVPGSGIGELKLEFA------E-GESPITQCLRTRTAKVTTSVG-ARWLSCSCRPI
PDDG-TDVVVLVSFVDVTDDFRERTDLAWGPVRDPLTGLYNRSGIIRELESHMAGLDADSCCVAIFYIDLDNFKLVNDSLGHAVGDEVLHTIAERLALIT
PDCAAVGRLGGDEFVLVSTLGTSDEIEAQIDKIRGTVDEPVTVTSRSEPVRASIGVATVNADEFTAADLLRDADIALHRARKASRASYVRFQTQHREELQ
RQQRIEEELRRVLDTDQLEVHYQPIVSTGDGTLVGLEGLLRWHHPELGSISPTEFIPLAEGSNLIDRVGNYVLETAAAEVAAVPELRR--VMLCINVSRR
ELTNGQFPDRLRDTITRSGLDPAAFCLEITESALDPLDGDLLTLLRDVRELGTQVSLDDFGTGASSLSEFYRLPVSVLKTAKSFVDALDEHPSAKSILAG
IVTMAHAAAMRVVAEGVETESQAAIVAEVGCDLAQGYHFGRPAPLAEVIA----------
>tr|M0QKZ8|M0QKZ8_9ACTO Putative signaling protein OS=Gordonia soli NBRC 108243 GN=GS4_23_00270 PE=4 SV=1
--------------------------------------------------------------ISA---QKEAEAALRAQ----AALVDHVSDAVIAVDMN
QRIRSWNPAAEQMYGLVAEEAIGTS---MTS-AMGTSIRPS-G----AVALGGT--VDEIHRRADGREFAARMAVTMMDD------GYLIVS--EAARRP
LFERLG---TILAALHQAVIVVRDGGHIELANPAATAMLGLEDAEIPGLSTDSLSIDFL------G-DTSPIKACLSTGTATIATPQG-RRWLSCSVRPI
DDDT-NEAAALVSIVDITDRHQEASRLAWEATHDFLTGLLNRAGLVAALSNHLRALSG-DQRVGVYYLDLDGFKAVNDTRGHAAGDELLKIVGQRLDDMV
CGPSVVGRIGGDEFIIAATLSSAEQIGDHISHIRGVVSEPIDIGGRRERVTTSIGVAMTSAQQQTPEDLLRDADIALYEAKRNGRASYVQFEVRHRRDLE
RRRSIERHLRMSLTPEHFRLDYQPIVATSTQRVVGMEALLRWRHPVFGLVPPAEFIPLAERSDLIDLIGAHVFDTAATALASNEWPDD--AMLSLNMSRS
GMTAEDFLPRLDGLLDDTIDDPSRLCIEVTESSLDARDSEALATLSAVRERGVHVALDDFGTGASSLSELYRLPISILKTAKAFVDALDQDDRAEAILSS
IVSMAHATGTQVIAEGIETKAQAQAVARIGCDYAQGYYFGFPRPIGTRPQ----------
>tr|I2PWH0|I2PWH0_9DELT PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Desulfovibrio sp. U5L GN=DesU5LDRAFT_0159 PE=4 SV=1
--------------------------------------------------------------IAS---RLLAEDRLRDAERKYRSIFENAVEGIFQTTPA
GRYLEVNRTLARIYGFTSVAEMREF---FRD-IRNQYVDPR-R----RDDVREL--AESEIRKKDGTVIWISENARVVRGADGLPAYYEGTVVDITDRKR
AEAALA---TLFANSPQ----ID-HRNIVDANKGFEALFGYRTADIQGFGMRAF-----I--VPEHLL-TEAGKPVVRE------CDGRLIPVSMI-GFP
IEIA--------IYQDISERKAFEEQITHQAFHDALTGLPNRSLFADRLERALTRARRGDSQYAVLMIDLNKFKGINDTLGHQAGDQLLVEVARRLSGCV
RSMDTVARLGGDEFAVILEEFKTKEVMTVVDRIGAGLGKPFVLCGKTVTPEASIGIVLHT---AAADDLLRDADIAMYRAKEQGRAS-MIFDRKMHQEIL
EAVSLEADLRQALEAGELLLHYQPIVDVKDSRIVGFEALVRWDHPDRGLVPPGQFIPLAEETGLILPLGRFVIDEACRQLRAWQLEMPADLSVSVNVSCR
QFVKDGLVEHVAQVLAATGLPPACLKLEITESVLMHDAEHTARELTRLKALGVKIAIDDFGTGYSSLSYLRQLPIDHLKIDRSFISGQGCDGESQEIVKS
IISLARSLGLTVIAEGVECPDQLDRLRLADCDKAQGFMFSRPVEATAAGR----------
>tr|D2SGK4|D2SGK4_GEOOG Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Geodermatophilus obscurus (strain ATCC 25078 / DSM 4316
--------------------------------------------------------------VAP---RNQTESALHQLEMKYRAVTESASDAIVSADAR
GLIVSWNRGGEAMFGYAAEDVIGKP---LTI-LMPEYRDAH-E----RGMRFLL--TEVHAQRADGTEFPVELSLSH--WAEGEGRFFTGILRDITERKR
AEAALA---RLQRVSVASNETVDDRSSNIWVRPDDDRLLPFLQATGTGLPGRVL-----A--SKQPSWI--PRRAAARD---------------AAFAFP
VLVGSEVTAVLEQLGRVVERELAQGRLTHHALHDPLTGLPNRVLLLDRLEVALAQRSRG---VAVAFVDLDHFKLINDSLGHAAGDTVITAAATRLRAVV
RPGDTVARFGGDEFVVLAESVVDRDVEGLAERLAGALAEPFDLAGDEVFVTASIGIAVSSGGG-DAHGLLRDADAAMYRAKEAGRARHEVFDSVMRAGAI
RRLEIVNDLHRALERNQFVLHFQPQIDLRTNSLIGVEALLRWVHPERGLIPPLEFIPVAEETGLINDLGRWVLRAACQQGRTWLDRFPEPLVMSVNLSGR
QLHQPRLAEEVAAALEDSGFPADQLVLEITESVLMNDTAATIHTLEALKELGVRLAIDDFGTGYSSLTYLQRFPIDILKIDKSFVDGLGSANEESAVTRT
IVALAKTLRLETVAEGVERSEHVRELQSLHCDIGQGYFFARPLDAGALTT----------
>tr|K6GC81|K6GC81_9DELT PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Desulfovibrio magneticus str. Maddingley MBC34 GN=B19
--------------------------------------------------------------ISG---RRRAEEQLDAAERKYRAIFENAVEGIFQTTPG
GRYLEVNRTLARIYGFDSVDEMTEH---FRD-IKNQYVDPN-R----RDDVRQL--SESAIRKKDGSVIWISENARVVRDPDGAVAYYEGTVVDITDRKR
AEEQLA---ALFANSPQ----ID-RRNIVDVNHAFEDLFGFKAAEIKGYGMRAY-----I--VPKHLL-GESGKPMVRE------RDGRLIPVSMI-GFP
IEFG--------VYQDISERKAFEEQITHQAFHDALTGLPNRSLFADRLDRALTRARRGDYQYAVLMIDLNKFKGINDTLGHQAGDMLLVEVSRRLMACV
RSMDTVARLGGDEFAVILEELKSKEVMAVVDRIGAVLGKPYVLCGTTVTPGASVGIVLRT---QSPEDILRDADIAMYRAKESGRPS-MVFDRQMHQEIL
DAINLEADLRAALDRGELLLHYQPIVDVQTGRIEGFEALVRWDHPDRGLVPPVQFIPLAEETGLIQPLGRFVIAEACRQLRQWQLDLPEQLSVSVNVSCR
QFVKDGLVDHVAGVLESTGLDPACLKLEITESVLMHDAQHTAGELNRLKALGVKIAIDDFGTGYSSLSYLRQLPIDHLKIDRSFISGDDVNGESQEIVKS
IIALARSLGLTVIAEGVEHQDQLEKLRSADCDKAQGFMFSRPVDKDAALT----------
>tr|K9S9T8|K9S9T8_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Geitlerinema sp. PCC 7407 GN=GEI7407_2503 PE=4 SV=1
--------------------------------------------------------------AID---RKQADSRLHLME--R--VIAASSNGIVVTQPD
NPVIYVNPAFEGITGYSGEDVLGKN---CR------LQGPD-R----DQAVEEL--RVLHNTRKDGVDFWNELFVAPVFDRQGYLTHFVGIQNDITERKR
AEEALR---QILNSLED----VDATRQVLYLNPAAERIYGRPIAEF-------------L--QHPDLWLQIEAAALLRQEYRVVRPDGEIRWLRDRGHVV
YDAD--------ISSDITTRKRMEEQLRHDALHDALTGLPNRALFMDRLRQSAAKDTRPDHLFAVLFLDLDRFKMVNDSMGHLVGDQLLVAIARRLQKRL
RPSDTLARLGGDEFTILLEDLKSAEAQHVAGRIHRALRVPFNVCGHEIYINASIGIALSRDAGHQPEHFLRNADAAMYHAKGLGKNRYEVFSPVMHTQAV
RFMRIEMDLRRALERREFVVHYQPIVELQTGALTGFEALVRWHHAEHGWISPAEFIPVAEETGLIIPLGQWILEEACHQLKIWQSAFPHNLAMNVNLSVK
QFSQPDLIAQIDRVLHSIQPAPGSLKLEITESAIMDNAEAAVLILQTLQAREVRFCIDDFGTGYSSLSQLHRFPAHTLKIDRSFVNRMDVRDEDAEIVRT
IVTLAHNLRMDSVAEGIETPTQLHQLRSLGCELGQGYLLSRPLSAADAEA----------
>tr|W9DB29|W9DB29_9ACTO Signal peptide protein OS=Gordonia alkanivorans CGMCC 6845 GN=V525_18910 PE=4 SV=1
--------------------------------------------------------------ITA---QKAIEAALRRQ----AALLDHVSNAVIAVDRN
MTVRSWNPAAEQMYGITAGDAVGRE---LGS-VTGGDLDVE-A----AVALGGT--VDQLHRRADDRTFLAHISVTSMDD------GFLIVA--EPTRRP
LIERLG---TILAALHQAVIVVRADGGIELANPAAATMLGPH--GVPGSFVHDLPLDFV------G-GESPIVRCLRTRTATISTPGG-ERWLSCSCRPI
DDDT-AEAVVLVSFADITERYRERARLAWDAVHDPLTRLYNRAGILNEIESHLNALAEETGCVAIYYIDLDNFKLVNDSLGHAVGDEVLHTVAQRLAGAT
PREGAVGRIGGDEFVLVTTHTGTAEIERRIESIRAAIRPPLSVTDRSEPVRVSIGVATVAADRYTPTDLLRDADIALYQARKVSREPYVQFRTHHRDELQ
RRQRIEEELRRALTPSQLEIHYQPIVSTDSGTLVALEALLRWNHPELSSIPPTEFIPLAEQSTLIDKVGAHVLATACAEVAGTPQLQQ--VMLCVNVSRR
ELTNGKFLHRLRETCEQTGMNPRSLCLEITESALAPLESDLLNLLRDIRTLGVSISLDDFGTGASSLSELYRLPVGILKTAKAFVDALGENPNARTILAG
IVDVAHAVGVRVIAEGVETPTQAATIAAVGCDFAQGYHYGRPKPLAEIVA----------
>tr|H5TSC3|H5TSC3_9ACTO Putative uncharacterized protein OS=Gordonia otitidis NBRC 100426 GN=GOOTI_214_00070 PE=4 SV=1
--------------------------------------------------------------IT----------SLRRQ----AALINHVSDAVISASDE
LVIRTWNPAAEQLYGIPVSDAVGMP---LNALVVDESHSPE-D----IVGVGGV--IHAIHRRADGHTFAARVAASVMDD------GYLLVV--QPVRTP
LVRRLG---TILAALQQAVILVRDGGRIELANPSAVLMLGLSARSIPGTPLTDLPLEFA------E-SPSPIEMALRLGIATANTLSG-TRWLSCSGRRI
DTEE-SAAVVLVSVTDVTEQHHAVSDLTWQAKHDHLTGVLSRAALSEQIDLKIREMV-DGDRLAIYFLDLDGFKLVNDTRGHSAGDEVLRIVSQRLQEAV
GTHGCVGRIGGDEFIVVSSHNALAAIHAQIDAMRDVVGRPIDLSGTAEYVSASVGLALAKAEHTTADDLLRDADIALYEAKN-ANVPYVSFNPQQRANVL
ELRNTARDLRSDLESGAVRLDYEPIVRCCPDPVVAFDAVLRWEREGVGHHGPRDAVVAAEHSRLVPELSGFVISTATAAFTGPDWPHG--CRLTVRMSRN
QVCSAGFLPSIDAAIG-AGLDPARLCIIVAEFAVAD-DPATLSIVSQLNARSIAVALDDFGAGMSTLAILHRLPVTTVRIARAFTDTIAVDSRAAATLGK
LVELTHELEMNVAVKGVDNRQQADVITQLGVDFAQGAHFGAARRAPTFTT----------
>tr|F8A5A2|F8A5A2_CELGA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cellvibrio gilvus (strain ATCC 13127 / NRRL B-14078) GN=Celgi_2
--------------------------------------------------------------ASQ---VRAAEARMRDSLDLVTGILSAATQQAVIADLE
GRIETFSRGAELLLGYTADEVLGQR---TDM-LR----APG-A----DVSTWGV--PAWQLRAKSGELREVLLSVTV-RQAGGVPAGLILVATDQAERRA
RDAALA---AAFVNAPIGVGLVSITGRVLQVNPALEALLGYSAAELTGTTVARLAHPEDL--PLVA---------MLGEEHRFLRADGRTVWAQVSLASV
MPDQ--------MLTDVTARREAEAELMFNALHDGLTGLPNRALITEHLAGALNRA-RSGTDVGLLYVDLDNFKDVNDSLGHAAGDELLVEVGRRLAGAL
EDQELAGRLGGDEFVVVSEDVRTEELTAVADRVARALAIQLPLAGQMVTASASIGIARRTSHT-TAEDLLREADIAMYRAKANGRARYEFADPGLQVRAL
RQIELEADLRATLAKGRLFLDYQPCFDARDGRLIACEALLRWEHPTLGVLAPGQFLDVAEDRALMSPLGSWVLEEAAEQAARWYAQHGAP-EMWVNVSAA
QMGRHAFSQTVADVLARTGLPAHLLCVELTERHALSSAPDVLEDLCALPAIGVRLAIDDFGTGYAGLEYLRRLPASTLKVDASYVAAIGRDRAGAALVST
VVNLGHALDLTVVAEGVETAAQREAVTALGADILQGFHLGRPGPPARIDQ----------
>tr|G4HZQ9|G4HZQ9_MYCRH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Mycobacterium rhodesiae JS60 GN=MycrhDRAFT_2989 PE=4 SV=1
--------------------------------------------------------------VTE---RRRIEANLRQERD-YADAVLNSLPGAFYHNED
QRLVRWNRNLERITGYSPSELLNME---AAK-FIPQDREPV-A----KQI-------EAYYLVKDGRRIPYL-FTGVRFDHDG-QRGFVGVGTDLTERRR
MEDALR---EVVTHAPDGIIVTDI--HRIFQNRRLSELLALTPENLASV-ARIMVDPGEF--LDKARWLLE--------E------------------VE
LLNG----TVLDSYRDVSDRHQVERLLRHLATHDDLTGLANRALIEDRVEELAVDP-RSGRPFAVLFIDLDRFKFINDGYGHAFGDALLKAVGELLVTVV
REGDVVARHGGDEFLILLAEIAGEEATVVAQSIADHLATPFMVRGREVYLSGSIGVSLFPDGR-TAGTLISNADVAMFHSKEEGRNTVRLYTQQMGERSL
QRVQLETALRAALPEGQLRLVYQPKVSLADGRIVGCEALLRWLHPDLGLVGPSRFIPIAEESGLIVPLADWVLREVCRQAGEWLDA--PPLSIAVNVSAQ
QIHDQDVVAWVVDTLHETGFPPDLLELELTESLITRNSEAVVATVDGLRAAGVRVAIDDFGTGYSTLADLRRFHVDALKIDRSFVRGMLAESNDATIVRA
VITLAHNLGITVVAEGVETEEQGTFLRQAGCDEAQGYVFGKPVSAKNLED----------
>tr|A9WG22|A9WG22_CHLAA Diguanylate cyclase OS=Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl) GN=Caur_2977 PE=4 SV=1
--------------------------------------------------------------VTD---RIEAERRLHLQ----VHVLSQINEAVIVTDRS
GAIVYLNDMAAYLYGVNPAEVLDQP---LSR-LFVAEPLPA-Q----TVE-WNP--LELLHRLPDGRTIIVDVSIDPLHHDELANGGTLIVVRDITSRKQ
VEERLR---LVVIHTNDAVLILDAGPFIRYANAACSRLTGYATHELIGRSLRILHGPATDVMSLQTLWQAMEQR-----ELLYYTRIGEPIWVDLSLSPV
TDDYGQTTHFIALLNLIADHTRLNAQLHYQVRYDPLTGLPNRHLLQERIELALRDARERRHTVALLFIDLDGFKQVNDSLGHPIGDRFLKHVSQAFAACV
RPQDTLGRMGGDEFLLLMPDLPDRLADIAAQRLLDALQTPYIHEGQELRLTASIGISLFPRDGVDSVTLLKNADSAMHRAKEFKRSGFLHYRPEHSRRAH
TRLALEVQLRRAIERQQLIVYYQPQYDLVTEQVASVEALVRWHHPQRGLIPPGEFVPIAEESDLIIEIGSWVLREACRQAMAWHKAGYPLLRISINVSAR
QLLRPEFVSEVAAILHSSGLPANWLELEITEGVMLDDPIYAARQIDQLRQLGIRIALDDFGTGYSSLAYLRQLRLDALKIDQAFVRAIDEQTNSRALLRA
IINLAHSLGLAVIAEGVETPEQRSALISMGCDILQGYLFAHPLPADEVWP----------
>tr|B8G9I9|B8G9I9_CHLAD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Chloroflexus aggregans (strain MD-66 / DSM 9485) GN=Cagg_3503 P
--------------------------------------------------------------VTD---RVEAERQLNLR----ARVLSQINEAVIVTDRS
GAIIYLNEMAAYLYAVQPEAIIGQP---LSR-LFTAEPLPY-Q----PVQ-PSV--QELIHRLPDGRAMMVEVRIDPLYHDELANGGALIVVRDITARKQ
AEERLR---LVVVHTNDAVIILDAGPFIRYANAACSQLTGYATNELIGRSLRILHGPATDSVTLNRLWEAMERQ-----ALLYYTRAGKPIWVDLSLSPV
TDEYGKATHFIALFNLIADHANLNAQLNYQVRYDTLTGLPNRNLLQERIDLALRDARERRHIVALLFIDLDGFKQVNDSLGHPIGDRFLKHVSQAFAACA
RPQDTLGRMGGDEFLLLMPDLPDRLADIAAQRLLDALQTPFLHDGHELRLTASIGISLFPRDGVDVVTLLKNADSAMHRAKELKRSGFLHYRPEHSRRAH
TRLALEAQLRRALERHELAVYYQPQYDLVSEGITGVEALVRWHHPQRGPIAPGEFVPIAEESDLIIEIGSWVLREACRQAMAWQQAGYPLLRISVNVSAR
QLLRPEFVAEVAAVLHATGLPAQYLELEITEGVMLDDPIYAARQIDQLRHMGVRIALDDFGTGYSSLAYLRQLRLDALKIDQAFVRAIDEQTNSRALLRA
IINLAHSLGLAVVAEGVETDEQRAALLSMGCDVLQGYLISQPLPADEVWP----------
>tr|I0HWB3|I0HWB3_RUBGI Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Rubrivivax gelatinosus (strain NBRC 100245 / IL144) GN=
--------------------------------------------------------------LSG---QRISDAALHLR----DRALGAISQGVMISDAA
GLITYVNAGCTVITGYTEAEMVGRP---AAF-LHGADTDPG-L----LRALRDA--LELLNYRKDGTPFWNEMSLAPVLDAQGVTIQFVGVMSDVSARRE
LAAQLL---LVFEQSGEGFYVADLQHRIVKVNQAFTTITGYDAADVLGRTPDLFRSKRHDRQFHAAIWAEAAEHGHWHGWSRRKDGSEYPQWLSMSLV--
ADAGGQAAHFIASFIDITRRKDAEDSIRRLAHYDSLTGLPNRALLSDRASHALRVARRNRESMALMFIDLDHFKIINDSLGHAVGDALLVALAERFRGAL
REQDTLSRTGGDEFVLLLPGTDGSRV---ARKLLALAEKPYHLEQYELSITPSVGIALYPADGADYNALAQSADAAMYQAKQNGRNRFCFYTAEIQAQSV
RMLLLENALRRALERGELSLNYQPQFRSDGRCIVGAEVLLRWQHPELGAVSPAEFIPVAESSGLITSIGEWVLRTATQQLRTWLTNGIPVKTLAVNLSAV
QFRQPHLADIVAGILSEAGIEAGRLELELTESVASDDPVAAVTAMNELHARGVQLSIDDFGTGYSSLSYLKRFKVYKLKIDRSFIGGVIDSAEDQAIVTA
IINLAKGLGMRTIAEGVETEAQAHFLRKRGCDELQGYWLSRPLRADEFAA----------
>tr|F4H4G5|F4H4G5_CELFA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBR
--------------------------------------------------------------VTQ---SRRTLDDLRASHDLIAGILSAATEQAIIADLD
GNVELYSAGAERLLGWSAQEVLGGP---AAR-FD----SPA-A----DLSDWGL--DPWIYRTKSGEDRAVLVSVTV-RRGPAGPTGLIIVATDRTASIA
REAELA---RAFDNAPVGVALLDAVGRVLRVNRALCEILGFDEVELLGVDLTALVHPESL--PDLL---------VDGTEHRYTSGAGDDVWVQMNLALV
-RDG--------QFADITERRRAEAELTHNALHDSLTSLPNRALLTERLDRALARA-GDGTTVAVLYLDLDNFKDVNDSLGHAAGDELLVHIGRRLTTVM
RETDTAARLGGDEFVVICEDLTSEDVGAVTHRITQALAVQVPIAGRMVTVSASIGIAHSTSHD-RSEDLLRAADIAMYRAKANGRSRYEFADPHTQVRAV
RQLELESDLRSALDDDQLLLDYQPCFDARTGQLVAVEALIRWEHPARGRLSPGDFLDVAEDRDLMVPLGLWVLRAACAQAAGWHRAYGCP-EIWVNVSSR
QLGRHEFSARLADVLAETGLPPEKLCVELTERQALSSAHSTLADLHALPGLGVRLAIDDFGTGYAGLDYLRRLPVSCLKVDASYVASLGVDSTGTAVAAG
VVNFGRALDLTVVAEGVETPQQRDMIVDLGADVLQGFLLARPAGPDVVDR----------
>tr|A8FPU7|A8FPU7_SHESH Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Shewanella sediminis (strain HAW-EB3) GN=Ssed_0257 PE=4
------------------------------------------------------------------------------------------ALPLAIIQG-
YHFIGANPLTLSYFQTQTDNFVNATPYDFSPRIQSSGRNSYAQQMMRHALEGDVIEFNWLHLSQQGRELPTRVSLFPFEFEGSPVAMFEPSNRRSRSRES
ANNPKELLSITLEDSAEAAYITDAEHRIIAVNKAMCRISGYSADQLLHKNAEVIDLKRHTAAEEMEHNNALEERGNWQGEVWKQRSDGTEFPAWKSCRKI
LAE--ERVYYVTIFSDISTKKKLEAKLTEQAMFDTLTGLPNRHHLKLLLNQALQEIKETGKMGALMFLDLNGFKNINDCFGHATGDKVLQLVSARLEASC
IEKADIARLGGDEFTLVLRDCNGQEVEDISQQIMSLFEAPFEIDDQKLYLGTSIGIALFPEHSSEANKLLSLADTAMYSAKQSP-EHVLFYNNSMHEEAE
QKLTILSELRHAHNLKQFSLAYQVIVNLECNSVIGAEALLRWQKPDGEILNATDFVPLLEEAGLLITIGQWVLKQACLQVATWRTQHAPDLKACVNVSPM
QLEHPDFVQQVTEALTYSQLPANALVLEITELALLRQPQRVKKTLTLLKSKGISIAIDDFGAGLSSLSKLGSLPIDSLKIDAGFAHRLSEPQ-GKELCQA
MIKLAQALDISFVVEGIETKQQKEILKNMGKGFGQGYFFGHPKEAARFTPENFS------
>tr|B1KN60|B1KN60_SHEWM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella woodyi (strain ATCC 51908 / MS32) GN=Swoo_0256 PE=4 
------------------------------------------------------------------------------------------SPPLALIQD-
HQFIGANSAALSYFQTQSDGFIQASPYDFSPRIQSSGRSSYTRQMIEQASKGDITEFNWHYISRQGTDLPTKVTLFPFKLDELNVAQFESKNRRSQTRTK
ASNPKELMSLILEDNAEAVYITDSHHSILAVNKAMCRICGYSSEQLIGSKTDLINIDDHPLNVTAEYNKAIEDRGNWQGEVWKLRSDGSQFPAWKSCRKL
TVE--EQVYFVTIFSDISAKKQLESKLTEQAMFDSLTGLPNRFHLKKLLNQAIKQTEMRNTLGAVMFLDLNGFKNINDCFGHATGDKVLQLVSARLEASC
IENAEIARLGGDEFTLVVQNCTSQEIEALSKQIMSLFDTPFEIDDQKLYLGTSIGISLFPEHSNHADKLLSLADTAMYSAKKSP-SHLLFYDKKMHQEAE
QKLHTLSELRHAHNLDQFKLAYQVIVNLECNSLIGVEALLRWQKPDGKVINACDFVPLLEETGLLITIGQWALQLACEQMLEWRN-YSPDLKVCVNVSPM
QLEHHDFVQQVTQSLQSSKLPAEALVLEITELALLRQPETVTKTLLALKALGVSIAIDDFGAGLSSLSKLGTLPIDSLKIDAGFAQRLSEPQ-GKELCQA
MIQLAQALDISFVVEGVETLQQKEILEKMGKGFGQGFFFGHPEDATKFTLDNFS------
>tr|A0A0C3R2L2|A0A0C3R2L2_9GAMM Contig_9, whole genome shotgun sequence OS=Shewanella sp. cp20 GN=DB48_03045 PE=4 SV=1
------------------------------------------------------------------------------------------YPCLAILKG-
HAFIGASQGTLDYFDTQRDSFITATPYDFSPRIQASGINSVAQQLIERVQQGEVVSVNWLHMSQLGRELPTRVTMLPARLEESQVVRFEPADRRAKHREK
ASNPAQLVSSILEDSAEAVYISNHEHKIIAVNKAMCRICGYSADQLLNKSPLDLQGFCEVSNRQSDFLQSLEDRGSWQGETLKTRSDGSQFPAWVSCRKL
QID--GEIFYVTLFSDISAKKRLESRLTEQAMVDTLTGLPNRHQLKQQLDQALASAQKEDKLGAVIFMDLNGFKNVNDCFGHATGDKVLQLVAARLEASC
IDKASIARLGGDEFTLVLSDCQDAEIEAISRQLLAIFDAPFEINSQKFFLGTSIGIALFPEHSDQAAQLLSFADTAMYCAKKSP-NHVLFYDSQMHRDAQ
YKLKTINDLRHAFNLNQFQLAYQVIVNLDGNQVLGVEALLRWHKSDEEIIEASDFVPLLEETGLLINIGQWVLTTACEQVAKWRDEIARPLQACVNVSAT
QLEHPDFVQQVTRALIASGLPATALVLEITESALLRQPKRVKATLIHLKALGVRIAIDDFGAGLSSLSKLGSLPIDTLKIDAGFAERLNEPQ-GRELCQA
MIQLAQALKIQFVVEGVETLAQKQILAGMGQGFAQGYFYGYPTAAEQFTKANFI------
>tr|A9KU46|A9KU46_SHEB9 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella baltica (strain OS195) GN=Sbal195_4269 PE=4 SV=1
------------------------------------------------------------------------------------------KTPLALIQG-
FSFISANQATLGYFETEYDAFVNATPYDFSPRIQSSGRNSYAREMILEAIAGNNVEFNWLHLSQLGNELPTRVNLYRCYLQQQPVVEFQALNRRNQMREI
ITDPKEILSTTLEESAEAVYITDSDDQILAVNKAMCRICGYSAEQLISKTPEFLELKSHHLGAETECQTALKQRGFWQGETWKKRSDSSNFPAWQSSRKI
ITED-GAHYNVNIFSDISTKKLLETQLTTRAMYDTLTGLPNRFHLKQILNTALEKLKTDLALGALMFLDLNGFKNINDSFGHSMGDRVLQLVAARLEAGC
IEKADIARMGGDEFTLVLQDCSCDEIQLFAEQILSLFESPFEIEGQKFFLGTSIGIALFPTHSDKAGQLISLADTAMYCAKKSL-PHLVFYDKAMSQAAE
LKLQLINSLRHAHSLKQFTLAYQAIVDLHTNQTIAAEALLRWQKSPTEYYDAADFVPLLEETGLIVSIGQWVLEQACVQAAQWRAHNQADFRISVNVSPL
QLEHLDFIDQVINALDMANLPAEALILEITESALLRQPEQARLTLNRIKALGVSIAIDDFGTGLSSLSRLGTLPIDSVKIDAEFALRLNEVS-GQKLCNA
IVQLAQALDIHFVAEGIETQQQRDIMTDMGQGFAQGFLFGYPSSVDNFTQTFLT------
>tr|B8CUT3|B8CUT3_SHEPW PAS:GGDEF domain protein OS=Shewanella piezotolerans (strain WP3 / JCM 13877) GN=swp_4779 PE=4 SV=1
------------------------------------------------------------------------------------------PSALAIVKG-
YHFLAANQATLSYFESVEQNFVHATPYDFSPRIQSSGRNSHGQQKLREAAKGNIVAFNWLHISQQGNELPTKVTLYPVKLRDEDVIQFTPMDRRGKRRTR
SNNPKELMSITLEDSAEAVYITNEDHRILAVNKAMCRICGYSAEHMLVKTPKELGLEAMLN--DTLNANPLKEKGNWQGEVWKYRSDGSKFPAWQSCRRI
YAD--NTVYFVNLFSDISEKKRLEAKLTQQAMYDKLTGLPNRFHLIKILNKAIEDIKQHSMIGALMFLDLNGFKNINDSFGHATGDKVLQLVAARLETCC
LEDAEIARLGGDEFTLVLPKCKNQEIEAFSDLVLSLFDAPFEIDGQKFYLSTSIGISLFPQQSHEANQLLSMADTAMYSAKKSP-NHIRFYNAAIREAAE
KKLHILNDLRHAQSLRQFSLVYQQIVDLESNEVIAVEALLRWQRSNGDILEASEFIPLLEETGSMVNVGLWALEQACTQMAQWHTQYNNTLKITVNISTS
QLEHPDFVSMLTKVLQQTQLPSDKLIIEIEESALIRKPAMMSAVLSELKQLNIGIAIDDFGAGLSSLSRLGSLPIDCLKIDSSFAQRLHEPQ-GKELCKA
MVQLAQTLNICYIAEGVETKEQKELLAKMGNGYGQGYHFGWPATADVFATESLC------
>tr|A4Y276|A4Y276_SHEPC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella putrefaciens (strain CN-32 / ATCC BAA-453) GN=Sputcn
------------------------------------------------------------------------------------------QTPLALIQG-
FSFISANRATLNYFGTHYDAFVNATPYDFSPRIQSSGRNSFAREMILEAIAGNHVEFNWLHLNQQGRELPTRINLYRCYLQQQPVVELQALNRRNHVREA
ITDPKEILSTTLEESAEAVYITDDDNRILAVNKAMCRICGYSAEQLISHTPAMLESRNLSQGEETDCQLAIKQRGSWQGETLKKRSNGSTFPAWQSSRRI
VVDG-ETPYHVNIFSDISTQKQLETQLTTRAMYDTLTGLPNRFHLKQLLNSALEKLQTDNLLGALMFLDLNGFKNINDSFGHSMGDRVLQLVAARLEAGC
IEKADIARMGGDEFTLILQDCSCEEIQLFAEQILSLFDSPFEIEGQKFFLGTSIGIALFPTHSDQATQLISLADTAMYCAKKSP-PHLVFYDKSMSQAAE
IKLKLINSLRHAHSLKQFKLVYQAIVDLHTNQTIAAEALLRWQKSPTEHYEASEFVPLLEETGLIVNIGQWVLEQACQQATLWRSQYQSDFKISVNVSPL
QLEHVDFVEQVINALEMAALPADALILEITESALLRQPEQARLTLNRIKSLGVSIAIDDFGTGLSSLSRLGTLPIDSVKIDAEFALRLNDIS-GQKLCYA
IVQLAQALDIHFVAEGIETQQQKDIMTDMGQGFAQGFLFGYPSAVEHFTQTFLV------
>tr|F7RTZ5|F7RTZ5_9GAMM Sensory box protein OS=Shewanella sp. HN-41 GN=SOHN41_03866 PE=4 SV=1
------------------------------------------------------------------------------------------EEPLALIQG-
FSFISANHATLTYFGTEYDAFVNATPYDFSPRIQSSGRNSSAREMILEAIAGNHVEFNWLHLNQQGNELPTRINLYRCYLQQQPVVELQALNRRNQIRES
ISDPKEILSTTLEESAEAVYITDADNRVLAVNKAMCRICGYSAEQLINKTPDFLEARSLNLGEETDCQTALKQRGSWQGETVKRRSDGSTFPAWQSSRKI
VTDD-GALFHVNIFSDISTKKLLETRLTTRAMYDTLTGLPNRFHLKQILNDALENLKKNLSLGALMFLDLNGFKNINDSFGHSMGDRVLQLVAARLEAGC
IEKADIARMGGDEFTLVLQDCSCDEIQLFAEQILSLFDSPFEIEGQKFFLGTSIGIALFPTHSDQAGQLISLADTAMYCAKKSQ-PHLVFYDKSMSQAAE
LKLKLINNLRHAHSLKQFTLAYQAIVDLHTNQPVGAEALLRWQKSPTEHFDAAEFVPLLEETGLIVGIGQWALEEACQQAALWRAQYQSDFRISVNVSPL
QLEHVDFVGQVISALEISALPANALILEITESALLRQPELARQTLKRIKALGVSIAIDDFGTGLSSLSRLGTLPIDSVKIDAEFALRLSDIS-GQKLCHA
IVQLAQALGINFVAEGIETQRQKDIITDMGQGCAQGFLFGYPTSVEQFTQTFLA------
>tr|A0L295|A0L295_SHESA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella sp. (strain ANA-3) GN=Shewana3_3946 PE=4 SV=1
------------------------------------------------------------------------------------------QTPLALIQG-
FSFISANSATLDYFGTEYDALVNTTPYDFSPRIQSSGRNSFAREMIIEAASGNHVEFSWLHLSQQGKELPTKVRLYPCYLQQQAVVELQALNRRTQVRPS
ISDPREIMATTLEESAEAVYITDADNRILAVNKAMCRICGYSAEQLIGKTPEFLEAKILPSGQETDCQAAMKLRGFWHGETLKQRSDGSHFPAWQSSRRI
ETDD-NALYHVNIFSDISTKKLLETQLTTRAMYDTLTGLPNRYHLKQILNSALDKLKDDSALGALMFLDLNGFKNINDSFGHSMGDRVLQLVAARLEAGC
IEKADIARMGGDEFTLVLQECSCEEIQLFAEQILSLFDSPFEIEGQKFFLGTSIGIALFPTHSDQAGQLISLADTAMYSAKKNQ-PHLVFYDKAMSQAAE
LKLKLINNLRHAHSLKQFNLAYQAIVDLHTNKPIGAEALLRWQKSPNEHYEAAEFVPLLEETGLIITIGQWALEQACKQAAIWRASYQPDFKVSVNVSPL
QLEHVDFVGQVISALEMVALPAEALILEITESALLRQPELARQTLERIKALGVGIAIDDFGTGLSSLSRLGTLPIDSVKIDAEFALRLNDVS-GQKLCHA
IVQLAQALDIHFVAEGIETQQQKDIMTHMGQGFAQGFLFGYPSSVEQFTQAFLA------
>tr|B0TPL9|B0TPL9_SHEHH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella halifaxensis (strain HAW-EB4) GN=Shal_0314 PE=4 SV=1
------------------------------------------------------------------------------------------STALAIMQG-
HHFLAASPAALSYFESLEQNFIHATPFDFSPRLQSSGRNSYGLQMIKKAAKGEVVSFNWLHMSQQGKELPTVVTLHPAQLDDSRVVSFRPIDRRKRSRMS
ISNPKELMSITLEDSAEAVYITNEDNLILAVNKAMCRICGYSAEHLLGKTPQNLKLELQLE--DQAHDTPLKGRGSWQGEVWKCRSDGSTFPAWQSCRRI
YAD--NTVFFVNLFSDISEKKTLEAKLTQQAMYDKLTGLPNRFHLIQILSKAINNIKRSEMIGALMFLDLNGFKNVNDSFGHSTGDKVLQLVAARLEACC
IENAEIARLGGDEFTLVLPECHNQEIETFSELILSLFEAPFEINGQKFYLGTSIGISLFPQQSDDPNQLLSMADTAMYSAKRSP-NHVRFYNATIREAAE
KKLHTLNDLRHAQGLGQFSLAYQSIVDLESNDIVAVEALLRWTQSHGEIIEAQDFIPLLEEAGLMVNVGQWALEQACTQMLKWHQEFDSSLKISVNISRS
QLEHPDFIPMLKGLLTRTQLPANALIIEITERTFIRRPKLMTKVLVQLKEMNVAIAIDDFGAELSSLARLSSLPIDSLKIDAGFAQRVDNKQ-GQKLCKA
IMQLAQTLEIDFVVEGVETQAQRDLLLSLGKGMGQGYFFDRPVIAESFTLELLS------
>tr|Q8E8V4|Q8E8V4_SHEON Bifunctional diguanylate cyclase with PAS sensory domain/signalling protein with EAL domain OS=Shewanella oneidensis (strain MR
------------------------------------------------------------------------------------------KTPLALIQG-
FSFISANSATLDYFGTEYDTFVNATPYDFSPRIQSSGRNSFAREMILEAVSGINVEFSWLHLNQQGNELPTRVNLYRCYLQQQPVVELQALNRRTQVRPA
IADPKEILSTTLEESAEAVYITDIDNKILAVNKAMCRICGYSAEQLINKTPFFLEASPLNASDESECLQALKQRGFWQGETLKQRSDGSTFPAWQSSRRI
AAD--GLEYHVNIFSDISTKKLLETQLTTRAMYDTLTGLPNRFHLKQILNGALDKLKDDLALGALMFLDLNGFKNINDSFGHSMGDRVLQLVAARLEAGC
IEKADIARMGGDEFTLVLQDCSCEEIQLFAEQILSLFDSPFEIEGQKFFLGTSIGIALFPTHSDQAGQLISLADTAMYCAKKNQ-PHLVFYDKSMSQAAE
LKLKLINNLRHAHSLKQFKLAYQAIVDLHTNKPIAAEALLRWQKSPTEHYEAAEFVPLLEETGLIVSIGQWALEQACKQASVWRAQYQPDFKISVNVSPL
QLEHVDFVGQVVNALEMVALPAEALILEITESALLRQPEQARHTLERIKALGVGIAIDDFGTGLSSLSRLGTLPIDSVKIDAEFALRLTDAS-GQKLCHA
IVQLAQALGIHFVAEGIETQQQKDIITHMGQGFAQGFLFGYPSYVEQFTESYLA------
>tr|A8H9M6|A8H9M6_SHEPA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Shewanella pealeana (strain ATCC 700345 / ANG-SQ1) GN=Spea_3953
------------------------------------------------------------------------------------------STALAILQG-
HHFLAATPAALNYFESQEQNFIHATPFDFSPRLQSSGRNSYGQQMIKKAAKGEVVSLSWLHMSQQGKELPTVLTLYPAQLDNIKVVSFKPLDRRKRSRES
ISNPKELMSITLEDSAEAVYITDEDDRILAVNKAMCRICGYSAEHLLSKTPSDIKLELQHQ--NQAPDNPLKGKGSWQGEVWKCRSDGSTFPAWQSCRRI
YAD--NTVFYVNLFSDISEKKALENKLTQQAMYDKLTGLPNRFHLIQLLNKAINNIKQSDSIGALMFLDLNGFKNINDSFGHSTGDKVLQLVAARLEACC
IENAEIARLGGDEFTLVLPQCHSQEIEAFSELILSLFEAPFEINGQKFYLGTSIGISLFPQQSDEPNQLLSMADTAMYSAKNSP-KHIRFYNATIREAAE
KKLHTLNDLRHAQSLGQFSLVYQSIVDLESNRTVAIEALLRWNQSNGEVIEAHDFIPLLEEAGLMVNVGQWALEQACIQMLKWQQDYDSELKISVNISRS
QLEHPDFISMLEGLLTRTCLPASALIIEITENAFIHRPKLMTKVLAQLKEMGICITIDDFGAGLSSLSRLSSLPIDSLKIDAGFAQRLDCNQ-GRKLCKA
IMQLAQTLEINFVAEGVETQAQRDMLLSLGKGMGQGYFYNRPTAAENFTHEVLD------
>tr|F3LSW2|F3LSW2_9BURK PAS/PAC and GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Rubrivivax benzoatilyticus JA2 = ATCC BAA-35 GN=RBXJ
------------------------------------------------------------------------------------------SQGVLITDAN
RRTTYVNAAFVEL-TGYAEEMIGSS-CAL--LQGPGTSA-TVQAMRAALDRGEPFHAELLNYRKDGTPFWNELKIVPVHADDGTLTQFVGVQRDVTARRD
AMNKLSLAARVFEQSNEALAIADVDGRFVAVNDAFTRITGYAEHEVIGQNPRLLKSGLHDDDFYHRFWQELRTRGRWEGEIWNRRKDGTVYPEWLSVGRV
VDEAGRTLNYVASFSDITARKHAEENVRRLAYYDPLTGLPNRALLQERASQALQIAVRTGEPVALMFLDLDHFKNVNDTLGHPIGDRLLVALAQRMRPAL
RDQDTLARVGGDEFVLVLPSTDATGASYVAQKLLQIVQEPVQLDGHDLTVTPSIGVAVFPTDAADYDTLFAFADAAMYRAKMSGRATFSFYTAEMQAQMA
RTLRVENALRRALERDEMQLHYQPQCQAADGRIVGVEALLRWQHPELGWIGPAEFVPLAETNGQIAVIGRWVLDTALRQLRAWQLAGLPPLRMAVNLSAV
QLRQPGLAELVGELLRRHEVDPAWLELELTETMAWDDPEGSARQIARLRAMGLRIALDDFGAGYTSFSHLSLFQAGTLKIDRSLVAGIERGSHQASVVAA
IVNLARTLRMHTVAEGVETPGQREALLAAGCESAQGWLYGRPMPAEAFEALIRE------
>tr|I0HQ12|I0HQ12_RUBGI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rubrivivax gelatinosus (strain NBRC 100245 / IL144) GN=RGE_1758
------------------------------------------------------------------------------------------SQGVLITDAN
RRTTYVNAAFVEL-TGYAEEMLGNS-CAL--LQGAATSA-TVQAMREALDRGEPFHGELLNYRKDGTPFWNELKIVPVRDDDGVITQFVGVQRDVTARRD
AMNKLSLAARVFEQSNEALAIADLNGRFVAVNNAFTRITGYAEHEAVGQNPRLLKSGLHDENFYQRFWHELQTRGRWEGEIWNRRKDGSVYPEWLSVGRV
VDDAGQTVNYVASFSDITERKHAEENVRRLAYYDPLTGLPNRALLHERASQALQIAVRHGEPVALMFLDLDHFKNVNDTLGHPVGDRLLVALAQRMRPVL
RDQDTLARVGGDEFVLVLPATDAAGATHVAQKLLQIVQEPLQVEGHELTVTPSIGVAVFPTDAADFDTLFAFADAAMYRAKMSGRATFSFYTAEMQAQMA
RTLRVENALRRALDRGEMQLHYQPQCTVADGHVVGVEALLRWNHPELGWIGPAEFVPLAESSGQIAVIGRWVLDTALRQLRAWLDAGLPPLRMAVNLSAV
QLRQPGLADLVGELLRRHGIEPAWLELELTETMAWDDPEGSARQVARLRAMGLRIALDDFGAGYTSFTHLSLFQAGTLKIDRSLVANITSGVSENSVVAA
IVNLARTLRMHTVAEGVETPAQREALLAAGCESAQGWLYGRAMTAEAFLALMLD------
>tr|W0V1P2|W0V1P2_9BURK Janthinobacterium agaricidamnosum NBRC 102515 = DSM 9628, complete genome OS=Janthinobacterium agaricidamnosum NBRC 102515 = DS
------------------------------------------------------------------------------------------ADAILLIQDE
-HITDVNPAALALFQCDKLRMLGQRLCDFSPLQQPDGELSLSTRMARQVYATGNCRYDWRYLTCQGELFWGEVLLTSITLDHEY--LFYAVIRDISARRL
TERSLYLAAQVMEHARDAILVTDRQHMVITVNRAYTEITGFDAGDMIGKLFSVHRSELDEQFFFHQIWAELERSDHWQDEILGKRKDGTSYPGWLSLTAI
RDSQGEISNYMAILSDITDRKQSEEHTRHMAEHDFLTDLPNRVLLLDRLSLALVAARRRHSMLAILFLDLDHFKNINDTMGHHVGDLLLQEVAQRLVHCV
RGVDTVSRQGGDEFVIILADIGGDQAAHVAASVLQAVTQPYQIAEYELHVSTSIGVSIFPSDGEDMETLIKNADIAMYHAKENGRNGFQFFNADMNAQIV
ERVTFENGLRHALDNDEFILEFQPSLDVSSGAIVGAEALIRWQHPALGLLKPERFIAVAEDAGLMIPIGNWVLLHACLAAQRWHDAGYK-LVVAVNLSVA
QFMQKNLPAIVGAALDESGLPAACLELEITETIIMKDGINVNDVLDQLHRMGVQLAIDDFGTGYSRLGHLRNYPIDKLKIDRSFMAGVGGADDDGTVAAA
IIAMAKGLKLKVIAEGVETAQQLAFLRRQGCDQYQGFYASDAVRASELGKMLH-------
>tr|A0A0C9P0U8|A0A0C9P0U8_LEGPN Gmr_1 protein OS=Legionella pneumophila GN=gmr_1 PE=4 SV=1
-----------------------------------------------------------------------RFNQLKISEERYRNLMNAVSDGIFIHNLQ
GAFLEVNEAACLSLNYSREELINSY-VWIEVGFSQESLN----QLWENVQKGP-INTEGIHRRKDGTTFPVDVRLAVF--NATREKLVLAIVRDITHQKR
SEATIRKLTRALEQSPVLVIITDKTGTIEYVNAKVIEQTGYRKEELVGGNTRILRSGQTPHEIYKTMWEHLANGEEWHGELLNKNKSGEHFWVSAIISPI
RNENEEITHYLAVMEDVTQKKSYEEMLKYQATFDNLTNLPNRLYAVNKLERAISKSHINNQKLAVLFLDLDEFKQINDSLGHAIGDLLLKALSERFLSMI
RQTDTIARLGGDEFMMILENIMQKDAESIAKKCREICSQPFVIESQELLVSTSIGIAIYPDHGKDAKTLMRNADTAMYQSKIRGKNNWTVFQKTMIDGAN
NHIRIKTELHQAFTRNELYICYQPIIELKENKVVAAEALLRWQNTTLGQINPDQIISLAEETGMIIPFGYWILDKVCTQAKEWEFITGSKIKVAVNISTL
QLKQKDFIHKVQLILKRTKLSADSLIFEVTESAFIDDSKFILSQLNKLSDMGIHFSLDDFGVGYSFLQYIKSYPFKNLKIDRVFIQGVNTNHNQLSLINS
IITMARNLKLSVIAEGIETAEQLELMRSMNCDMVQGWYFSKPLSGDKFLFFLM-------
>tr|A0A098FZ69|A0A098FZ69_9GAMM Diguanylate phosphodiesterase OS=Legionella fallonii LLAP-10 GN=LFA_0042 PE=4 SV=1
-----------------------------------------------------------------------HLNQLKVSEERYRNLMNAASDAIFIHDLN
GLFIETNKAACKSLGYTLEELRQLY-VWVEVGPSKEELQ----QLWITLQEDTLVTVEGKHKRKDGTVFPVDVHLGFF--TATDEKLVVAIVRDLTEQRR
SQAVIRQLTRALEQSPVLVLITDKVGTIEYANAKVLEQTGYGTEELLGQNPRILQSGHTPAETYQLMWKQLHQGQEWRGELLNKNKQGELFWVSAIISPL
RDEGEGITHYLAVMEDISQKKSYEEMLKYQATYDNLTNLPNRFYGYNRLEHAIANAYLNKNKLAVLFLDLNEFKQINDSWGHAAGDVLLKALSERYLSII
RQTDTIARIGGDEFMMILENLNYADVELIAKKCYEVCLRPFVIESKELMVSSSIGIAIFPEHGKDAKTLMRNADMAMYHNKTHHQAPWTVYTRAMDEVGS
NYIRIKTELYKALTRDELYLCYQPIMDIKNNVLIAAEALLRWHSSTLGDVLPDQFIPIAEETGIIIQLGYWILRKVCKQIKEWQMLTSSELKIAVNISTM
QLKQKDFVNKVKMIIEEMGVTPESLIFEITESAFIDDTKFILSQLNRLNEMNIHCSLDDFGMRYSSLNSLRSYPFKSLKIDKTFIQGINNHSNDLSLVNS
IIAMSKTLKLRVVAEGIETEEQLRVMRSLSCDMVQGWYFSEPLSIDHFLSYLN-------
>tr|Q2BPB1|Q2BPB1_NEPCE Regulatory component of sensory transduction system OS=Neptuniibacter caesariensis GN=MED92_15203 PE=4 SV=1
-----------------------------------------------------------------------SRQILNRERGLLRGLIDALPDHIFIKDKE
GKYLGCNKAFQSFTGHQEADLIGKT-DQFSESNHSDTLQ----VINNLLPINR----EAWTHEQDGSPILLESQLAPF--LDMDPQGIVGISRDITEKRK
AEERILTLSQAVEQSPVSVVITNLKGEVEYVNSTFESVTGYSQAEVLGKDSSILKSGKTPPGRYADMWAKLVQGESWQGEFQNKKKNGEIFWEQAHIAPV
LDAEGEVRHFLAVKQDVTKQKAQEEKILHQAHFDGLTELPNRFLAMHRLETMMHEAKRNQHQIAVLFLDMDDFKKVNDTLGHDMGDKILVEAAKRLQGSV
RDSDTIGRLGGDEFIVLINHLEREQALPIAQNLLQQFRSSLTIDGRDILLTMSIGIALYPGDGTTPSELLRNADSAMYHSKAAGRNSFHFYTQEMNIEAN
RRLQLEEQLHNALDRNELRLLYQPVVDLKTRKIVGAEALLRWDSKELGAISPEEFIPVAEHTGLIVEIGKFVLDDALRTTSRWIKTFIPDFHIAINLSPR
QFRDPHLIDNIESFVNSYGLEGRNLELEITEGVLMSQHADVEEAIAKLTQKGISISMDDFGTGYSSLSYLRSYPFNILKVDRSFINDISVDAADLELVNA
SIDMAHGLGLKVIAEGVETEEQTALLLRKNCDMAQGYYFSKPIPADELEEILK-------
>tr|V6EYE9|V6EYE9_9PROT Uncharacterized protein OS=Magnetospirillum gryphiswaldense MSR-1 v2 GN=MGMSRv2__1009 PE=4 SV=1
-----------------------------------------------------------------------MRKTLEDSEDRFRRLSDVT-NEAICIHFQ
GRILDCNRAFHDLFGYERADFDTLT-AWVIH---TDDLP----LAREMVRIQYQKPYEVRGVRKDGSVFPMEI--HSK--ESWMVAVRVTCIRDLTEQKK
AETSLNLLSQAVEQSPVAVAVVTDQGLVEYVNPAHQRITGHAADTVIGHPLAGLYPGQ-SRAWFGEMWQALCRGADWGGEVPVVAEDGKLRWQQIFASPV
APQGHEITHHLVVVEDVSLRKEQDRKILHQALYDGLTDLPNRAMALDRLTVATEEARDAGTRVGLLFVDLDDFKGINDSLGHEYGDELLILASERLCQAV
GEGGMVARFGGDEFLVILP-LVSEQAEWAADRIVQAFVEPFTISRRDLITTASIGVALYPEDGRTPQTLLRNADIAMYQSKLAGRNRYCCFTARMNDEAE
ARLRLESELRRAVGTEQLFLHFQPLVHVESGRVAGIEALLRWNNPELGSVPPDRFIPQAETCGLIVPIGRDVLRQACQTALPWLQGGHPDLLLCVNVSPR
QFQDGAFLDDVRTILRETGFPAGNLELEITEGLLLKERGDIDGLLQGLHDMGVHLAIDDFGTGYSSLSYLERYPFHTLKIDRSFMIGMLERHERKVLVDT
IVAMATGLGLKVIAEGVETAEQLARLRAIGCDIAQGYLFSRPVPAEQIFALLD-------
>tr|W6MEA4|W6MEA4_9GAMM Putative Diguanylate cyclase OS=Candidatus Competibacter denitrificans Run_A_D11 GN=BN873_90019 PE=4 SV=1
-----------------------------------------------------------------------IEAALHASELKYRNVFATIGDALFLDGRD
GRILTVNPAACTLYGYSRKELLALK-DILASDPT--DAQ----L----PRAESRRLMDRWHRRKDGTAFPADLWVRHF--NYKGHTITVAAVRDMSAQKL
VERKVVRLNSLLSRTNAAIMRQEVLVSISFVNPETSEAAAYALAEGMGPCGMAFRLGNPVNDPDSGPWQEWALGVRAAAAFPLRRSGGVIGCLT---ACA
LNLAGEVSFALDLFDRETQREVVAQHIQHMATHDPLTGLPNRTLLLDRLSQAIHGARRKQHYVGILFLDLDHFKTLNDSLGHDIGDQLLRAVTERLRDSV
RQEDTLARQGGDEFILVLPDMAEAFAGRVAEHLLRALRAPFALYHHIMHVNASIGISVYPVDSEDPMTLIRFADSAMYHAKAAGRADYVFFTSELNVRVS
ELFILSNQLRQALEREEFILHYQPQIDLATYRVTGMEALIRWRHPDKGLISPIKFIPIAEEAGLISAIGEWTLRTACAQARRWQDAGLPAVPIAVNLSAP
QWLQPDLEKQVITALESQSLAPHLLELELTESLLMRDTDKMIQTMHRLRARGVRFAVDDFGIGYSSLSYLKQFPVDHLKIDQSFVRDIPADPDDAAIATA
IIQLGKSLRLTVIAEGVETSAQLNFLREHGCDIAQGYYFSSPLPADGCAEFLA-------
>tr|A6D0T4|A6D0T4_9VIBR Uncharacterized protein OS=Vibrio shilonii AK1 GN=VSAK1_10383 PE=4 SV=1
---------------------------------VDEVNAIPNQELRL---SGYNEIDGFIRVVNQFSTIKATRMKLLEEQRDLNSVIAATKIGTWYWNIK
SGEVKFNERWAEMLGYRLAELEPLTFTWE-KLCHPEDFVQSEEQLKRHFEGSEVYECQCRVQHKSGQWLWILARGQVVKWKTGEPIEMFGTHLDVTEKSH
AEEELRMSASVFDNTREGILILDNLGLVRRVNEAFISANDYSKEELLGHSLESMIDESESQVRYAELKQKVLSNGFWRGELWLVRKDGQAYPELVSITAV
RDSQNRLSNVVALFTDISRLKEQEKQLELLALYDPLTKLPNRNLLVTKVSELLK-FNEFGRYMAVLFIDLDEFKKINDSFGHEVGDEALKLLASTLSKNI
PSNDILVRWGGDEFIIVLNNVRSDKVKSYASKLLNIISTMRTDLIHPQPFSASIGVTMTEADSTDIEHLIRQADLAMYESKLQGGNSISFFNPEHDRSKR
KRHAKKRQLEQAVSENELELYFQPKMNLRSNELIGAEALLRWNHPDKGVLTPEQFLFDIETPALQCEIGDWVMTQAVHQVSEWMKCGMD-IQLSINVSSY
QLDDINFTSRLRALLSQYKVPPSYVQIEILESSALELVERAQAVIERCQSFGVSVAIDDFGTGYSTLSYLRDLPADVLKVDKSFIIGLQKDSKNWGLLKA
VMSLASTFDKTVVAEGLEDWDAKELLLEVGCEIAQGYAIARPMKIEQFNRWYRQEQ----
>tr|A0A081FZ28|A0A081FZ28_9ALTE Diguanylate cyclase OS=Marinobacterium sp. AK27 GN=ADIMK_2085 PE=4 SV=1
---------------------------------QCDDDGIPLLPAPE---FGYGEVATLSHTLNTRDVTRKARDAVQFERDCLQNVIDGTNVGTWEWHVQ
TGKTVFNERWAEIIGYTLEELEPVSITWL-KFTHPDDLERSGDALQRHFSGEPYYECEARMRHRDGHWVWVLDRGKVFTWADGKPQTMFGTHQDITERRQ
AEEQLVLSASVFQHAREGIFITDAKGLIIDVNQAFSRITGYSKSDSVGQNPRILKSGRQDEAFYQAMWQELIRKGYWSGEIWNRRKNGEIYPEFLTISAV
SDAEGRHQNYVALFADISTLKAHEQKLEQIAHYDVLTGLPNRLLLADRLRQAIAHSNRHHHPLALLFLDLDGFKEVNDRLGHDIGDLLLIELSKQLKRTL
REEDTLARLGGDEFVAILPDIADKDCRPGIERILETSSKQLLIEGHPVQVSASIGVTFYAPNDSDADQLIRQADQAMYQAKLNGKNRYHIFDAKQDRSLR
HRYEEIEQIRHGLAHNEFELHYQPQLNLRTGQIVGVEALIRWNHPTLGLLSPGRFLPAIETHELMVLLGDWTIEQALTQLSRWQAQGLS-MVVSVNIAAV
HLQHSTFVPHLQEALARYPLKPDQLELEILETSALDNMTQVSKIMRECQAIGVMFSLDDFGTGYSSLSYLKHLPVRTLKIDQTFVRDMLEDPDDLAILKG
VLGLAEAFNLEVIAEGVESQAHGEKLLSLGCELAQGYGIARPMPADALPQWIRSSA----
>tr|R1ITI2|R1ITI2_9GAMM Diguanylate cyclase/phosphodiesterase OS=Grimontia indica GN=D515_00209 PE=4 SV=1
---------------------------------TRDMSGIPVAHIPD---FANKELSSLSTTMNNISLIRHSHNSLSLEHSRLQNVIEGTRTGTWEWDVV
SGYITYNGAWSDILGWDLEALNGPPNDWK-HFIHPEDKILSEQQLAKLFAREDYYDCDIRLRHFSGQWVHVLARGKIVEWDQGRPLKVLGTHQDITAHKK
AEENLKLAAKVFTHAREGIIIADSQTRIIEVNEAFCRITGYSLGEVKGKNPSVLQSGKQDGKFYKDMWRSLEKKGHWSGEIWNRRKDGEMYPELLTISAV
TDELGNPINYVAVFSDITAYKEHEHKLEKIAHFDQLTELPNRLLLGDRLKHAMKQAKRHKQFIAVIFLDLDGFKPVNDTYGHEVGDLLLQQLAIRMKNVL
RDSDTIARIGGDEFVAVLADLQSECCQPLLPRLLAATSEPMEVNGNLVQVSASFGITTYPQSEVNSDKLLRQADYAMYQAKLKGKRRYHFFDADLEKSLK
SQNEKLSQITNAIENGELFLRYQPKVNLRTGELIGFEALIRWLHPSKGELTPIEFIPQIENLALIIDVGNWVIDTALAELVYWQENGLS-TTVSVNLAPH
HLLQKDFIHHLRLRLARYPIKAEQLELEILETSAFEDFEAVSEVICQCRKLGVAFAIDDFGTGYASLTYLKQLPAQTLKIDRSFIRDMLIDPDDLAILEG
VISLANTFNREVLAEGVETKEQAQMLVWLGCDLGQGFGIAKPMIREEVIGWVDNWH----
>tr|H5SGB5|H5SGB5_9ZZZZ Response regulator receiver protein OS=uncultured prokaryote GN=HGMM_F24F10C19 PE=4 SV=1
-----------------------------------------------------------------------------ADLTWFREQLEQRQLALVTLEQL
AEEAKAERTVLERLGICSL--VTVP------LFASGQL----------------LGCLV-AAQQRERRLWSEEEIDLLTLVGQ--LITAAVLQRRAEQVE
AQHHAWLRATVL-ASPDALLVLDSEGTVRFASPASRSVLGIESHALIDRPLAAFIADPER-------------FQRWLAEVLLPDRATRIPSRVVEISGI
LRTDPHIAGIVLSVRDVTERYRAQQLLRERATRDALTGLVNRFGFLEALESYRPA--AADEALGVLCCDLERFSALNDAISWEAGDAALRSVATRLRHTP
-EALLAARLEADRFAVLLRAGDRQRLIRVAAQLLEALSDWYDVGGEEVYLSMRGGLALV-EPEDSPVAVLRRAEIAFQASKQRQRERLAVFDPELYQASV
DRQALERDLRRALEQGDLRLHYQPVVDLASGRIVSLEALVRWQHPVRGAVSPGVFVPLAEVTGLISQLTQWVLLQACRQLRGWLRLGLSDLTVSVNLSPT
DFLYIDVPQLAEDVLEVTGLAAERLTLELTESAMLDPAV-SRERLERLRALGVAVVIDDFGAGYSSLGYLKRLPVNGIKLDRELIVDIGEDAASEAVVRS
VLELARSLQLSVTAEGIEHERQLVLLRALGCDYGQGFAIAKPLPPEAIVDLLRG------
>tr|B9L066|B9L066_THERP C-di-GMP phosphodiesterase A OS=Thermomicrobium roseum (strain ATCC 27502 / DSM 5159 / P-2) GN=trd_1559 PE=4 SV=1
-----------------------------------------------------------------------------PSLPSLQSLLERGQPVVPRLEAL
DAGADDVRTFCTHLGLRSL--LAVP------LLAAGRL----------------IGCLL-AAQQRDERLWGEEELDLFTLVSQ--LYAASIQQRRAERAE
AQHHAWLRATVL-AAPDALLVLDANGIVRFASPAARTVLGLAPDQLVGRPLADLTTTPER-------------VASWALDGLRPERANRIPTRTVELSGV
LRSDRHIAGIVLSARDVTERKRAEQLLRERATRDQLTGLLSRFGFLEVLEALLHT--TTAETIGILCCDLERFSALNDALSWEAGDAILRAVAERIRRVT
-GALAAARLEADRFAVALTAPDRTTLVRLAEELLHELSGWYEVGRDEVYARMRGGLACV-EDGIDATTALRRAEIAFQVGKRAGQERLSVFDPVLYQASI
ERQFLERDLRRALEQGELQIHYQPVIAVSSGRLTSLEALVRWHHPDRGPISPAVFVPLAETTGLISQLTQWVLLQACRQLWAWSRAGLPELSISVNLSPT
DFLHLDVPQLVDDILQVTGLEPRRLTLELTESAMLDPAV-SRERLERLRALGIAVLIDDFGAGYSSLGYLKQLPVSGLKIDRTLVADIDHDPASTAVVRS
ILELAGALELSVTAEGIESARQLAVLRELGCHYAQGFFVGRPAPPNAIHHLLRR------
>tr|W6LR28|W6LR28_9GAMM Putative Diguanylate cyclase OS=Candidatus Contendobacter odensis Run_B_J11 GN=BN874_120004 PE=4 SV=1
-----------------------------------------------------------------------------ISEDQFRRLADNMRDLVCQIDIT
GTILYASPSYRAVLGYDPQALLGRS------IFRETAI----------------KTCQA-SQHANGDYLWLEVVGNPLCNPAGAVIGAVISSRDITERKQ
AEADLRLATQVFESSREAITVTAADTRILWVNRAFSDITGYSAAEAVGQTPRLLASGRHGRDFYQEMWRALTVTGRWQGEIWNRCKTGEIYPEWLGISAV
HDPQGHLTHYVGIFSDLSEHKARVDQIEFLAHHDPLTALPNRLLLQDRLDQALSQAERSQSSVALLLLDLDRFKLVNDSLGHALGDQLLQKVAMRLHQML
RDTDTLSRQGSDEFMIVLPDTGHEGAGHVARHLLECLDRQVQIADHSIGVTAGIGISLYPDHGQDRDSLFKQAGAALRYAKNGGGNTYRFFTASMNVNTL
ERLQLETDLRHALERNELLLHYQPQIDLRIDRIVGVEALLRWQHPERGLVSPGQFIPIAEDSGLIVPIGEWVMREACRQIHAWQQAGLPRITVAVNLSAL
QFQRTDLLDAVNQALTECGLAPEWLELELTESILIQDTDNALRTVRQLRAMGLRLSIDDFGTGYSSLSYLQKLAVHTLKIDQSFVRGLASDADSAAIVRA
VVQLAHSLKLNTIAEGVETDFQLAFLRNQGCDQVQGYYFSRPLPAVEFARLLAQ------
>tr|U3B0E3|U3B0E3_PSEAC Uncharacterized protein OS=Pseudomonas alcaligenes NBRC 14159 GN=PA6_021_00100 PE=4 SV=1
-----------------------------------------------------------------------------ASELRFRATFEQAAVGIAHLAPD
GQWLRVNQRLCQMLGYSREELVRLT------FQLGEDL----------------IMTRQ-LLRRDGSTLWANLSATLVRHTNGEPHYFISVVEDIGLRKQ
QEQALRQAATVFESTQEGVLVVDARRRVLTSNPAFTQITGLSAQQVLGRRLPLLPGNDLDRARYRTLWRKVQDSGHWQGELNSRRRDGSRFPFWLTISRV
RDCDPQQPQYVLTFTDLSQYRDSQERLAHLAHFDPLTDLPNRLYAMERLGHALDHAQRHNERVAVLYFDLDNFKTVNESLGHKVGDDLLIAVARRLQQRL
RNEDTLARLSSDEFLVVLENLQREEAANIARTLIELLERPLGSGGREAYLSASIGISLYPDDGLSSDDLLRNADSALHQAKQEGRNTYRFYTEGLTHQAH
TRLSLEVHLRQALKRGEFILHYQPLVNASNGEPVGVEALLRWNSS-EGMVSPAQFIPLAEETGLIVPIGNWVLREACRQMQFWRQQGLPLQTLAVNLSPR
QFRQADLLQQVREALHDSGLPAEHLELEITEGALIENLEQTQATLGALKGLGLKLAIDDFGTGYSSLAYLRRFPLDKLKVDQSFMRGVPEDQANLEIVAT
IVGLARNLKLCVLAEGVETGEQLQALRQLGCDQCQGYLFSRPLSAVQLAHWLRS------
>tr|Q1N484|Q1N484_9GAMM Sensory box/GGDEF/GAF/EAL domain protein OS=Bermanella marisrubri GN=RED65_14832 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------AIYHDHIKAPTDN-DIAIIEKASKLVSITMEKH
DDNRLMQAANVFEHASEGILITDIDGEIIDVNKAFTQITGYSKEDVVGKNPRILSSGKYEQETYEDIFSTLENIGQWKGEIWNKDKKGNLFAVLESISTV
YDDSGKPRNYIALFNDITNIKSHQEQLENLANYDSLTQLPNRTLLTDRMQQAMALAKREGHLLVVIFIDLDGFKPVNDRYGHDVGDRLLIAFSKRVSLLL
RSTDTLGRLAGDEFVTLLPNVQQENCEPLLERILSAVEKPFIIDEHQLKISASMGVTVYPQAELDADQLLRQSDQAMYLAKQDGKNRYHLFDATQHQLMR
DHHENLVRIQEAIKNKEFILHYQPKVNLRSGEVIGVEALIRWQHRDKGLLPPGSFLPLLDNHPAMIQFGKWVMHEALNQISVWQKQNLN-LNVSINIDPM
HLQSPDFISDLESALHFPDVNPSFLELEIVETAAIEDINVVSDTINRCHDLGVHFSLDDFGTGYSSLTYLKRLPIHVLKIDQSFVRDILSDPDDLAIVQG
VLGLAKSFNRTAIAEGVETQKHGELLLQLGCELAQGYGISRPIEAKAIPDWIKHWA----
>tr|A0A090BW89|A0A090BW89_9GAMM Sensor histidine kinase FexB OS=Thioploca ingrica GN=THII_3889 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------MLWLEINKVPLQDRQNQVMGVLGCFEDITERKM
VEDKLRQSIKVFENSAEAICITDANTRIIGINKAFTKITGYTAREVMGKTPKILKSGKHKSDFYEVMWNAILRLGHWEGEIWNRRQNGEIFLEWLHISVI
RDNQNQITNYLGIFSDLTSRKQTEQRLAYLVHYDDLTGLPNRTLFYELANRALYYAQQHSELVAIMFLDLDGFKYVNDTWGHLTGDLLLKKVASRLTECL
RKTDTIARLGGDDFAIVLENINNKEVDIFAQNILKMSLSAFKLNGQETFITMSIGISLYPNDGQEVDTLLKNADMAMYRAKENGKNNHQFYIARLNVLSH
QRLILETKLRHALEREELVLYYQPQLHLASGQIVGAEVLLRWQHPEMGLVLPYRFIPLAEETGLIVPIGEWVLQRTCLQYQRWREQGAL-LRMSVNLSSR
QFKQDNFIKRIGEIIEETCIDPTLLELELTESLLITDFDEVNHILHQLKEMGMLLAIDDFGTGYSSLSYLKRFPIDKLKIDQSFVRDVPNNKEDMSIIKA
IIALARSLRLTVIAEGVETKSQQIFLKSLKCDEIQGYLIGRPMPEQEFIQMLNNRA----
>tr|N8Y6Q5|N8Y6Q5_ACIGI Uncharacterized protein OS=Acinetobacter guillouiae NIPH 991 GN=F964_04041 PE=4 SV=1
----------------------------------------------------------------------QMNDRLENHQANLAFAHETAGIHSWVWNIE
KRTFEISDKSGAEF-KQLNLKHN----SVDEYVHPDDIVNYKTILKQHLKGQERFEAIYRVKR-DGQWCWIQDIGKVVKNINNKPLRMVGIQRDIQKEKT
DQEKLKLAANVLAQVAEGVFILDNNLCYLEVNPYFEKLLDYKQHNIVGNHLDITINNSRTQQMYNVITQSLIQKGEFESELQIDFTSGKKLALWVHINAI
YDEKNKFSNYVGIITDLTDRKKQEQRLSYLEHYDILTDLPNRFYFKQQLHNYLIHYSDSFKNFAVLRINIDRFKLFNEFMSHKEGDELLKQVAHRLRLCC
PNASLIAYLNNDDFAVIYNLSSNINIHQHTQHILDAFKQPFDVKEQEQTITISIGVALYPEHGLQLDSLNGHAESALHEAKRLGGNTVYFYSNKKTPLLN
QGINLENELRKAIKHKELTVHYQPKICVKTQRIYGFEALVRWQHPTLGYILPDIFIPLAEETSLISDIGLIVLHETCKQIQQWQSLGFDHFRVSINIVAQ
QIYRGQLVKDIDYALKKYNISGDMLELELTESSLFDKSEEVNFLLQQLKDRHISISLDDFGTGYSSLAYLTSYPFDILKIDRAFISKIGQEK-DEAIVNA
IIAMGNAIGITLVAEGVETKEQALFLQKHGCYILQGFYFSKALSSADSTKYLEQHKL---
>tr|A0A031LRU0|A0A031LRU0_9GAMM Histidine kinase OS=Acinetobacter sp. Ver3 GN=CL42_07015 PE=4 SV=1
----------------------------------------------------------------------KINDRLQHHQANLDFAHETAGISSWLWNIE
KRTIEISGKYGNQV-LHYQSATD----QINEFIHPEDQENYRKELRKHLRGNERFEAHYRTKV-KDQWFWIKDIGRVIRDENNKPLKMVGIFQDIESEKK
AQEKLKLASNVFNQVAQGVFVLDNNLCFLEVNPYFSELVNIPPQDIISKHIDITKSSSQLSQHHADITQTVLHTGQYDAEVTEEFISGKILTLWLHINAV
RDDKNRILNYVGIISDLTERKQNLERMAYLENYDLLTDLPNRVYFNLQLHQYLISKSKILSHFSIIRLNIDRFRHFNEFINHQTGDEVLKEVSRRLKYTC
SKAVLISYLNNDDFAMIYNLNHSYTIQQVVDQILEAFEIPFIIDGQEHMIHVSLGIAIYPNHGRQIGSLNSHAESALTEAKKLGGSTAYYYDNKPESIFG
SDIELERDLRLAIKNQDLEIYYQPKIESKTMQVSGFEALIRWNHPKYGIIMPDRFIPIAEMTSLISDIGKFVIFQTCKQLKIWHELGFDKLQISINVVAQ
QIHRGEFLNFIDQAVLKYSLKPEFIEFELTESSLLDKSSHVFDLLDQIKDKNFSIALDDFGTGYSSLAYLADYPIDTLKIDRAFISKIGTRK-NNAIVDA
IISMGKTMGMKLVAEGVEDIEQIEYLKKQGCDYFQGYYFSRPLNSADSTQFLQNEYQ---
>tr|N8Y989|N8Y989_9GAMM Uncharacterized protein OS=Acinetobacter gerneri DSM 14967 = CIP 107464 GN=F960_02359 PE=4 SV=1
----------------------------------------------------------------------QMNIRLENHQQNLAFAHEAADINSWVWNID
KRTVEFFGNQENMI-YQRTYQNN----EIYNQIHPDDLKTYGKLIRAHLRGHQRFEMSYRIYK-NNQWLWFHDIGQVIRNKNNKPLRMVGIRRNIQQEKS
DQEKLRLAANVFNQVDEGVFVLDHNLCFVEVNHYFEKLIGLDECQIIGKHLDITINHEEIRSLHTMMYQQLIQTGEFDAEATEEFISGKKLTIWTHINAI
TDENNKVIHYVGILTDLTERKKQEKQLSYLQNYDTLTDLPNRLYFNNQLHQYLSKNIPSYKQLAVIRINIDRFRFFNEYLSNHAGDELLKQVAQRLRHFS
PQALLISHLNNDDFAIIYNTNQKQTIQQYCQMILQKISQPYFFNDQEHFITVSIGVALYPEHGRQIDSLNVHAEQAIAEAKQLGGNTIRIYSTKQPVLLD
SNINLDRDLRQAIKNNQFEVYYQPKIGVLSKSIVGFEALIRWNHPVHGLISPDAFLPYAEESSLISEIGYFVLNETCKQIKSWQNQNIYDISVSVNVVAQ
QIHRGRLLADLKEALELYGISGQHLELEITESSLIDHSQNVEKLLSQIKELGILVALDDFGTGYSSFAYLTRYPIDILKIDKTFVNKIGDSR-DEAIVTA
MIAMGKSMGMRVIAEGVETIQQVNFLKNQGCDELQGYFFSKPLNAKESTDYLNEHKL---
>tr|U4NP11|U4NP11_ACIPI PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Acinetobacter pittii 42F GN=APICBIBUN_01067 PE=4 SV=1
----------------------------------------------------------------------KMNEQLESHHYNLAFAHETAGIRPWDWDIE
SQRLEITFDQQKQT-QTAVIHLN----TILDRIHPSDKKLFDERLKQHLEGVDHFNITFRILRRDGSWRWIHDVGRVIRDKTQKALRMVGMTRDIHQEKK
DQEHLRLSAIVLEQAAEGIFILDEHLNYIDVNPYYEKLTGFSKSELLNKELSITINQELQQQFHTSITQQLLETGEYMGQFDEKFSSGKSVYLWLHINVV
KDEFNQITNYIGFARDLTEQKRQEQHLSYLKNYDSLTHLPNRLYYYNQLHQYLVNPSYNIKNLALIRVNIDRFRAFNEFLNNDSGDELLKQFAQRLRLIN
INAILVAYLNSDDFAIIYEISPIPNVEQYCQNILQALNAPFYIDNHEYFITASIGVACFPEHGRQIDHLNNHAEQALSEAKRLGGNTICYYCNKTNHS-Y
KTADLEQELRKAIQNDEFVIYYQPKININDQSIIGFEALIRWQHPEKGLILPNMFIPFAERSSLISDIGKVVLDKVGKQLQEWKNAGYINIQVSVNIVAQ
QIHRGLLLNDLDEVLQKYNIQGSDLELEITESALLDNTANVKTLLHAIKQRDISIALDDFGTGYSSLAYLTEYPIDVLKIDRAFISKIGDHK-QEAIVNA
MIAMGKSMGLKLVAEGVETKEQVTYLQKQQCDFLQGYFFSRPIPAEQIIPYLQTNPH---
>tr|A0A013JXM3|A0A013JXM3_ACIBA Diguanylate cyclase domain protein OS=Acinetobacter baumannii 1130196 GN=J671_0374 PE=4 SV=1
----------------------------------------------------------------------KMNERLESHRHNLAFAHETAGIRPWDWDIE
KQKLEITFDQQKQT-QNTSLHLK----TILERIHPNDRKLFDERLKEHLEGKDHFNITFRILRRNGSWRWIHDVGRVIRDKTNKALRMVGMTRDIHQEKK
DQEHLRLCAIVLEQAAEGIFILDEKLNYIDVNPYYEKLTGFSKSELLNQQLNIAINQLQQQQFHDSITQQLLKTGEYMGQFDEKFASGKSVYLWLHINAV
KDEHNQVINYIGFARDLTEQKRQEQHLSYLKNYDSLTHLPNRFYYYNQLHQYLVNPSYSFKNLALIRINIDRFRAFNEFLNNDSGDELLKQFAQRLRLTN
INAILVAYLNGDDFAIIYEISPIPNIEQYCQNILQALNAPFYIDQQEYFITASIGVACFPEHGRQVDHLNNHAEQALSEAKRLGGNTISYYCNKTTNP-Y
KTADLEQELRKAIQNDEFVVYYQPKINLNDKSVKGFEALIRWQHPEKGLVMPNMFIPFAERSSLISDIGKVVLDKVGKQLQEWKKSGYTDIQVSVNIVAQ
QIHRGLLLNDLDEFLEHYQLDGSNLELEITESALLDNTDNVKKLLHSIKERNISIALDDFGTGYSSLAYLTEYPIDILKIDRAFISKIGDQK-QEAIVNA
MIAMGKSMGLKLVAEGVETEEQVIYLQKQQCDFLQGYFFSRPLHPNQIIQYLQSNTY---
>tr|D0SAC4|D0SAC4_ACIJO Diguanylate cyclase (GGDEF) domain protein OS=Acinetobacter johnsonii SH046 GN=HMPREF0016_00444 PE=4 SV=1
----------------------------------------------------------------------QINKDLKNKQEDLSLAHAIAGIRPWDWNIK
DRLIALTNKQEKVL-KNSTEHQL----QLQYLIHPNDIAPFKSAMKSHLRGHDHYDATYRVQHNNGKWYWVHDTGRVIRDTTQKPLHMVGIRRDIQHEKS
NQERLRLAASVLEQAEQGIFILDEDLRYIDVNPFFERLAGFDAAHINGKHLDIVANYSHQRTTHNQIIGHLLKNGEYDGELNEKFLSGKELCIWMHLNAI
TDEQNRVTHYIGIVSDLTERKLQEQRLSYLENYDTLTDLPNRFYYNYQLHQYLVSQQDSIKQLAIIRLNIDRFRPLNEFLSNNGGDELLRQVAQRLRLTN
AEALMVAHLNGDDFAIVYEVSHIPSVQEHIDRINKAFSLPFDIFGQEHIITLSMGISQYPEHGRQLDYLNNCAEQALSEAKRLGGNATKLYSLSNTVALE
EGIYLERDLRLAIQNNELVVYYQPKINFHNQKIYGFEALVRWNHPTKGIVPPGLFIPMAEKTSLISDIGRIVILQTAKQIKEWNKLGFDNICVSVNVVAQ
QLQRGQLLKDLDEALDRYKISGSSLELEITESTLVENSEAVKNLLETIKLRGIHISLDDFGTGYSSLSYLTDFPIDTLKIDRSFISKIGHYK-QEAIVSA
MIAMGKAMGMTVVAEGIETEQQLSYLQNLECDIAQGYLFSKPLPQLDATQYLRDHLD---
>tr|N8Q6Y0|N8Q6Y0_9GAMM Uncharacterized protein OS=Acinetobacter bohemicus ANC 3994 GN=F994_01828 PE=4 SV=1
----------------------------------------------------------------------KMNSDLENQQQNLVLAHEIAGLRPWDWNIK
DREILITNKQQKTL-KPLKQHQH----QLQNIIHSDDVEHFKSSMKQHLRGRDLYEATYRIQNSVGKWKWVHDIGRVIRDINQKALRMVGIRRDIQQERT
DQERLKLAASVLKQASEGIFILDEQLAYIDVNPFYEKLTGFSQEKIIGKHLDITANYSQQRDDHYLIINQLLTTGEYDGEMNEKFLSGKELTVWMHINAI
TDEQNRVTHYIGIVSDLTERKLQEQRLSYLENYDPLTDLPNRFYYNYQLHQYLVSQKDSIQQLAVIRLNIDRFRPLNEFLSNSGGDELLRQVAQRLRLTN
AEALFVAHLNGDDFAIVYEISHIPSIQQHCERISKAFSLPFNIFDQEHIITLSMGIAFYPENGRQLDYLNNCAEQGLTEAKNLGGNTIRYYSNKNTALLE
QGIYLERDLRLAINNNELVVYYQPKINFSDQNIYGFEALVRWNHPTKGIIPPNSFIPLAERTSLISDIGRIVIQQTAKQIRHWNDLGFNNICVSVNVVAQ
QLQRGQLLEDLDYAIQTYQISGSSLELEITESSLLENSITVKNLLDEIKERKINISLDDFGTGYSSLSYLADFPIDILKIDRSFISKIGENK-QEAIVSA
MIAMGKAMGMMVVAEGIETKQQLEYLQDLKCDIAQGFLFSKPLPESEATIFLEQHRL---
>tr|N9CC13|N9CC13_9GAMM Uncharacterized protein OS=Acinetobacter bouvetii DSM 14964 = CIP 107468 GN=F941_01000 PE=4 SV=1
----------------------------------------------------------------------QMNKNLEDQQQNLQLAHEIAGLKPWDWNIK
DRTISLSNHKGTSQ-RDSKEHHY----QLLHTVHPDDAEQFKNAMKQHLRGQDRYESTYRVQNSTGKWSWVHDIGRIIWDDSNKPLRMVGIRRDIQQERT
SQERLKLAASVLKQAAEGIFILDEELRYLDVNPCYEQLTGFRHEQMIGKHLDIAANYSQQRSAHAEILKQVLQHQQYDGELQEKFLSGKELTLWLHINAV
LDDQNRVAHYIGIVSDLTERKLQEQRLSYLENYDILTDLPNRFYYNYQLHQYLISQQDSLKQLAVIRLNIDRFRPLNEYLSNNGGDELLRQVAQRLRLTN
AEALFLAHLNGDDFAIVYEISHIPSVMEHCERIAKAFTLPFNILGQDHVITLSMGIALYPEHGRQLDYLNNCAEQALSEAKHLGGNTIRLYSNENTALLE
QGIFLERELRKAIQSNELVVYYQPKINFRDKNIYGFEALVRWNHPEKGIIPPGLFIPLAEQTSLISDIGRIVIQQTAKQIKKWNQMGFNNICVSVNVVAQ
QLRRGQLLIDLDEAIKANEISGDSLELEITESSLIENSETVKKLLQEIKSRHINISLDDFGTGYSSLSYLADFPIDVLKIDRSFISKIGQNK-HEAIVCA
MVAMGKAMGLTVVAEGIETEQQLQYLRNLDCDIAQGYLFSKPLPEAEATVYLKQNIR---
>tr|N8WNB1|N8WNB1_9GAMM Uncharacterized protein OS=Acinetobacter sp. NIPH 899 GN=F969_02697 PE=4 SV=1
----------------------------------------------------------------------QINIDLKNQQQNLELTHEIAGIRPWDWNIK
DRSILLTNKDEKVQ-RKSSEHHL----QLQHMIHPDDLAAFKSNMKQHLRGKERYEVTYRIQQAPGVWSWVHDVGRVIRDETHRPLRMVGILRDIQQERS
SQERLKLAASVIEQAAEGIFILNDELRYIEVNPYFENLSGFERNDILGKYLDITASHSQQRTIHSNIIKQVVKIGSFDGELSEKFLSSKEMPLWLHINAF
TDDEGRITHYIGIVSDLTERKLQEQRLSYLENYDTLTDLPNRFYYNYQLHQYLMTQKDSIKKMAVIRLNIDRFRPLNEYLSNNGGDELLRQVAQRLRLTN
AEALFVAHLNGDDFAILYEISHIPSVQEHCQRVAEAFQAPFHIFGQDYVITLSMGVAFYPDHGRQLDYLNNCAEQALSEAKNLGGNTIHFYSNENTALLE
QGIFIERDLRKAIQNGELVVYYQPKINFNDQHIYGFEALVRWKHPEKGIIPPDLFIPLAEQTSLISEIGRLVIQQTARQIREWNDLGFHNICVSVNIVAQ
QLRRGQLLDDLDQAITENQISGTSLELEITESSLIENSESVKNLLNQIKQRQINISLDDFGTGYSSLSYLADFPIDILKIDRSFVSKIGEHK-QEAIVSA
MVAMGKAMGMTVVAEGIETEEQLQYLRDLDCDIAQGYFFSKPLPELEATAYLEQNRI---
>tr|R9AXE9|R9AXE9_9GAMM Uncharacterized protein OS=Acinetobacter tandoii DSM 14970 = CIP 107469 GN=I593_01807 PE=4 SV=1
----------------------------------------------------------------------QMNRNLENQQQNLDLAHEIAGLKPWDWNIK
ERHISVSNQQQKKL-KHSKEHSI----QLQNIIHPDDLLCFKTALKQHLRAEDRYEATYRVQQSNGDWTWVHDIGRVIRNSNKKPLRMVGIQRDIHQERT
DQERLKLVASVLEQAAEGIFILDKHLNYVNVNPFYEKITGFDKGQCLGQHLALTSNHSAQQQNHQAILEQLARTGEYDGELTEKFSTGKELTFWLHINAI
QDEHNRVINYIGIVSDLTERKLQEQRLSYLENYDTLTDLPNRFYYNYQLHQYLVSHQDSIQQLAVIRLNIDRFRPLNEYLSNNGGDELLRQVAQRLRLTN
TDALFLAHLNGDDFAIVYEISHIPSIQQHCERIQDAFAEPFEIFGQDHIITVSMGISFYPEHGRQLDYLNNCAEQALTEAKRLGGHTMKYYSSDNTALLE
QGIYLERDLRQAIRNDELVVYYQPKIDFKDQHVYGFEALVRWNHPTKGIIPPALFIPMAEKTSLISDIGRIVIRKTAKQISYWNSIGFKNICVSVNVVAQ
QLQRGQLLSDLDEAIATYQISGESLELEITESSLIENSKTVKILLDQIKQRHINIALDDFGTGYSSLAYLADFPIDILKIDRAFIANIGDGK-QDAIISA
MVAMGKAMGLTVVAEGIETEQQLCYLEKLQCDIAQGYLFSKPLSEKNATEYLQLHKL---
>tr|A0A0A3W5W7|A0A0A3W5W7_9GAMM Uncharacterized protein OS=Acinetobacter sp. HR7 GN=GW12_02530 PE=4 SV=1
----------------------------------------------------------------------QINRALQDQHQNLELAHEIAGIRPWDWNIK
DRKITLTNKQEQIQ-RNSREHQA----QLHHLIHPDDIAHFRAMMKQHLRGLERYEATYRIQNTQGVWNWVHDIGRVIRDKTHKPLRMVGIRRDIQQERN
SQERLKLAASVLEQAAEGIFILNNELRYIEVNPFFEHLSGFERHEIIGKHLDITANHSQQRSIHSSIIKQVVKIGSFDGELNEKFLSGKEMPLWLHINAI
MDDEGRITHYIGIVSDLTERKLQEQRLSYLENYDTLTDLPNRFYYNYQLHQYLVTQKDSIKQMAVIRLNIDRFRPLNEYLSNNGGDELLRQVAQRLRLTN
AEALFVAHLNGDDFAILYEISHIPSVQEHCDRIAKAFTKPFNVFGQDYEITVSMGVAYYPEHGRQLDYLNNCAEQALAEAKNLGGNTVYFYSNENTALLE
QGIFIERDLRKAIQNGELIVYYQPKINFNDQSIYGFEALIRWNHPEKGIIPPGMFIPLAEQTSMISEIGQLVIQQTAKQIRKWNEQGFLNICVSVNIVAQ
QLRRGQLIDDLDEAIKANGISGSSLELEITESSLVENSETVKNVLNQIKERNIKISLDDFGTGYSSLSYLADFPIDILKIDRAFVSKIGDCK-QEAIVSA
MVAMGKAMGMIVVAEGIENDQQMSFLHKLDCDIAQGYLFAKPLPEQQATEYLEKNME---
>tr|D0SWS6|D0SWS6_ACILW Diguanylate cyclase (GGDEF) domain protein OS=Acinetobacter lwoffii SH145 GN=HMPREF0017_01750 PE=4 SV=1
----------------------------------------------------------------------QINHDLKNQQQNLKLAHEIAGIRPWDWNIQ
ERSITLTNKDEKIL-RDSKDHHL----QLQYLIHPEDLAYFKRNMKQHLRGQERYDATYRIKLSEGGWSWVHDIGRVIRDKNKKPLRMVGIRRDIQQERL
SQERLKLVASVLEQAAEGIFILNPELDYIDVNPHYEYLSGFERDEIIGKSLDIAVQNSQQRTFQANIVKQIQKIGSYDGEVYAKFLSGKESTLWLHINAV
TDDEGRITHYIGIVSDLTERKLQEQRLSYLENYDTLTDLPNRFYYNYQLHQYLVSQKDSIKEMAVIRLNIDRFRPLNEYLSNNGGDELLRQVAQRLRMTN
AEALFVAHLNGDDFAILYEISHIPSVQHHCERIAQAFSRPFNIYGQDHVITLSMGVAFYPDHGRQLDYLNNCAEQALNEAKNLGGNTIHFYSSENHSLQN
KGVFLERDLRKAIQNNELIVYYQPKINFSDQSIYGFEALIRWNHPEKGIIAPGLFIPLAEQTSLISDIGRLVIQQAAKQIRQWNDLGFNHICVSVNIVAQ
QLRRGQLLDDLDQAIADNQISGASLELEITESSLIENSEAVKNLLNEIKQRHIHIALDDFGTGYSSLSYLADFPIDTLKIDRSFVCKIGENK-QAAIVSA
MVAMGKAMGMTVVAEGIETEEQLEYLRDLDCDIAQGYLFSKPLPEQDATAYLVRDKT---
>tr|V2U3E4|V2U3E4_9GAMM Uncharacterized protein OS=Acinetobacter indicus CIP 110367 GN=P253_01279 PE=4 SV=1
----------------------------------------------------------------------QIHKALQDQQANLVLAHEVAGLKPWDWDIK
HRLITLTNHQQLKM-SGSKAHHH----KLQQLIHPDDLAHFRNTMKQHLRGQDRYEVTYRVQQSNGKWVWVHDVGRVIRDETRRPLRMVGIRRDIHQEKT
DQERLKLTASVLQQAAEGIFILNEDLRYIEVNPCFEQLTGFSREQIIGKHLDIASNYSRQRSMHNAIVKQLLKEGEYDGEMDEKYLSGKELTIRLHMNTV
SNEQNRSTHYVGIVSDLTERRRQEQRLSYLENYDTLTDLPNRFYYNYQLHQYLVSHQDSIKQLAVIRLNIDRFRVLNEYLSHNGGDELLRQVAQRLRLIN
AEALLVAHLNGDDFAIIYELSHIPSVQQHCERITKAFSAPFNIQGQDHIITLSMGVSLYPEHGRQLDYLNNCAEQALSEAKRLGGNTTKYYSLETTKLLE
QDVHIERDLRQAIKNDELIVYYQPKINFHDQQVSGFEALVRWNHPEKGLIPPGLFIPIAEQTSLISEIGHIVIQQTAKQIRDWQALGFDNIRVSVNIVAQ
QLQRGHLLEDIDEALNTYHISGESLELEITESSLLENTDEVKYILEEIKKRHIHISLDDFGTGYSSLSYLTDFPIDVLKIDRSFVSKIGHSK-QEAIVSA
MIAMGKAMGMTIVAEGIETEHQLQYLRKLDCDIAQGFLFSKPLPQQDATRFLSEKMQ---
>tr|N8WM01|N8WM01_9GAMM Uncharacterized protein OS=Acinetobacter schindleri NIPH 900 GN=F965_01748 PE=4 SV=1
----------------------------------------------------------------------QINLALQDQHQNLELAHEIAGIRPWDWNIK
DRTITLTTTQEKIQ-RSSGQHQA----QLHHLIHPDDLRHFKDMMKQHLRGQERYEATYRIQNTQGVWGWVHDIGRVIRDKTNKPVRMVGIRRDIQQERN
SQEGLKLAASVLEQAAEGIFILNQELSYIEVNPFFEQLSGFERQQILGKHLDITVNTSQQRSVHANIIKQVMKIGSFDGELNEKFLSGKEMPLWLHINAI
MDDEGRITHYIGIVSDLTERKLQEQRLSYLENYDTLTDLPNRFYYNYQLHQYLVTQKDSIKQMAVIRINIDRFRPLNEYLSNNGGDELLRQVAQRLRLTN
AEAMFVAHLNGDDFAILYEISHIPSVQEHCEHIAKAFSQPFNIFGQDYEITLSMGVAFYPDHGRQLDYLNNCAEQALSEAKNLGGNTIHFYSSENTALLE
QGIFIERDLRKAIQNGELIVYYQPKINLNDQKIYGFEALIRWNHPEKGIIPPGMFIPLAEQTSMISEIGQLVIQQTAKQIRKWNDQGFHNICVSVNIVAQ
QLRRGQLLDDLDEAIKLNYISGSNLELEITESSLVENSETVMNVLNQIKERDINISLDDFGTGYSSLSYLAEFPIDILKIDRSFVSKIGEAK-QDAIVSA
MVAMGKAMGMKVVAEGIETEQQLDFLRQLGCDIAQGYLFSKPLPEQQATEFLEQNMT---
>tr|N9CP18|N9CP18_9GAMM Uncharacterized protein OS=Acinetobacter towneri DSM 14962 = CIP 107472 GN=F947_00999 PE=4 SV=1
----------------------------------------------------------------------QTHLDLINQQHSLILAHEAAGIKAWDWNIR
ERSIVFGTSQQTRL-KNSKKHRN----KLQQLIHRDDIAHLHQTMKEHLRGQERYEATYRIQHNSGQWYWVQDIGRVIRDVTNKPLRMVGVRRDIHQERI
AQERLKLTASVLEQAAEGIFILDENLRYIESNPFYAQMSGFQRDHIIGKYLDLVKSNANPRMTQEEIVQQLLNKGEYHTEKSIKFRSGKELEVRLHINAV
KDEQNRIINYIGIVSDLTEHKLQEQRLSYLENYDALTDLPNRFYYNYQLHQYLISQQDSLQQLAVIRLNIDRFRPLNEYLSNNGGDELLRQVAQRLRITN
AEALFVAHLNGDDFAIVYEISHIPSIEEHCERITKAFNLPFNVQGQEHIITLSMGVSLYPEHGRQLDYLNNCAEQALSEAKRLGGNTIKYYTLDNTKLLE
QDVHLERDLRQAIKNDELIVYYQPKIDFHNYQVIGFEALVRWQHPTKGIIPPNLFIPIAEQTSLISDIGRVVIQQTAKQIREWNLLGFDHIQVSVNVVAQ
QLQRGQLLQDLDDAINTYQISGASLELEITESSLVENSTTVKSLLDEIKQRDIHIALDDFGTGYSSLSYLTDFPIDSLKIDRSFVSKIGNTK-QEAIVSA
MIAMGKAMGMSVVAEGIETEQQLQYLQNLNCDIAQGYLFSRPLPESEATQFLKANLV---
>tr|N9DDE8|N9DDE8_9GAMM Uncharacterized protein OS=Acinetobacter ursingii ANC 3649 GN=F942_02595 PE=4 SV=1
----------------------------------------------------------------------KMNERLENNAQNLRLAHEIAGIRPWHWDIE
HRKIELTTEQDRIT-KDWKSHQS----YLEKIIHPDDLLFVKRALYRHLRGYSRFDVIMRIQY-DDHWYWVQEVGQVVRHQSNIPLRMVGIRRDISQEKK
DQDRLKLAASVVQQAAEGIFVLDENLCYVDANPCYEQLTGFKKQEILGKHLDITQNDFQQKNMHLNITKQLLQKGEFDGELNENFLSGKEVSIWTHINAV
KNDNDQIINYIGIVSDQTEKKRQEQRLSYLENYDTLTDLPNRFYYNYQLHQYLVSQKDPIKQFAVIRFNIDRFRTLNEFLTNNGGDELLKKVAQRLRLTT
PEALLVAHLNGDDFAILYEISHIPSIEQHCSRIFESFIEPFHVQGHDIVVTVSMGVAYYPEHGRQIDSLNNHAEQALNDAKRLGGNTVCYYSPEKSALLT
QGVNIERELRNAIKNNELVVYYQPKVCAQSHDVYGFEALARWNHPTRGLIGPDLFIPIAQETSLISDIGRFVIMETAKQIRIWDDLGFKNICVSVNVVAQ
QIHRGQLLNDLDDAMQYYQINGKKLELEITESSLMDSSEIVQEMLQEIKQREIFISLDDFGTGYSSLAYLTEYPIDILKIDRSFISKIGNPK-QEAIVSA
MIAMGKAMNLTLVAEGVETQEQADFLNQQKCDILQGFLFSKPLNPEKSTEFLKTHKC---
>tr|N9AZK4|N9AZK4_ACIJU Uncharacterized protein OS=Acinetobacter junii CIP 64.5 GN=F948_01892 PE=4 SV=1
----------------------------------------------------------------------KMNERLEEHRQNLAFAHETAGIRPWEWNLE
KNTVGVTNHQKEVT-RNSENHYE----LLSKIVHPDDAERVKNTIYSHLCGQKRYEETFRIKRSNGDWSWIHDVGQVIRNKDGTPLRMVGIHRDINQEKK
DQERLKLAASVFEQASEGIFILDENFNYLEVNPKYEQLTGLDKQYILNKHLEITKQTQHHLNFHLSILDTLHEEFEYEGEFQETYLSEKSCFLWIHINAV
KDESDRVLNYIGIVSDQSERKHQEQRLSYLTNYDTLTDLPNRFYYHQQLHQYLVNE-ASIQHLAVIRLNIDRFRALNELLSNQAGNELLKQVAQRLRISN
IDALLVAHLSADDFAIIYEISPLPPIHQICNNIVEAFSKPFYIADQEHVVSISIGVAIYPEHGRQVDNLNTHAEQALTEAKRLGGNTIRYYSSERTNFVA
KHTDLELDLRKAIQNKELVVYYQPKINTQNSNITGFEALIRWKHPTKGLIMPDIFIPLAESTSLISDIGRFVLYEAARQLQVWQKLGFVHIHVAVNIVAQ
QILRGQLLQDIDAVLDQYSIGGENLELEITESAFLENTENVKMVLCALKERNISIALDDFGTGYSSLAYLTEYPIDILKIDRAFISKIGDPK-QDAIVNA
MIAMGKTIGLKVVAEGVETEQQRDYLKRQNCDILQGYLFAKPLTASDATDYLQQHMR---
>tr|N9LI64|N9LI64_9GAMM Uncharacterized protein OS=Acinetobacter sp. NIPH 284 GN=F908_02035 PE=4 SV=1
----------------------------------------------------------------------EINNSLQEHRQNLAFAHETAGIRPWEWNLE
NNTVGITNHRKEVT-RDSENHYS----LLHKIVHPDDLERVKNTLYKHLCGQKRYEETFRIKRPSGEWVWIHDVGQVMRNKDETPLRMVGIHRDINQEKK
DQERLKLAASVFEQASEGIFVLDDSFHYLEVNPKYEQLTGLDKQFILGKQLEITKQNQHHHNFHLSILATLHEEHEYEGEFQETYLSEKSCFLWIHMNAV
KDESDRVINYIGIVSDQTERKHQEQRLSYLTNYDTLTDLPNRFYYHQQLHQYLVNE-ASIQNLAVIRINIDRFRALNELLSNQAGNELLKQVAQRLRISN
IDALLVSHLSADDFVIIYEMSPLPPIHQLCSNIVEAFSKPFYIANQEYVVSISIGVAIYPEHGRQVDNLNTHAEQALTEAKRLGGNTIRYYSSERTNFVV
NHTDLELDLRKAIQNNELVVYYQPKITAQNCQINGFEALIRWKHPTKGLIMPDIFIPLAESTSLISDIGRFVLYEAAKQLQEWQKLGFTNIHIAVNIVAQ
QILRGQLLHDIDAVLDEYSITGENLELEITESAFLENTESVKTILCALKERNISIALDDFGTGYSSLAYLTEYPIDILKIDRAFISKIGNAK-QDAIVNA
MIAMGKTIGLKVVAEGVETEQQCEYLKRQNCDILQGYLFAKPLTAVHATEYLQQHMR---
>tr|N9RWI9|N9RWI9_9GAMM Uncharacterized protein OS=Acinetobacter sp. NIPH 2100 GN=F887_01267 PE=4 SV=1
----------------------------------------------------------------------QMNESLEEHRQNLTFAHETAGIRPWDWNLE
NHTVGVTNHSNAVT-RNSENHYT----LLHKIIHPEDIERVKNTLYNHLCGQKRYEETFRIKRQNGEWTWIHDVGQVIRDKDDTPLRMVGIHRDINQEKK
DQERLKLAASVFEQASEGIFILDENFNYIEVNPKYEQLTGIDKQAIVNKQLEITKQNQHHHNFHLSILDTLREEHEYEGEFQETYNSEKSCFLWIHINAV
KNEQDRVINYIGIVSDQTERKHQEQRLSYLTNYDTLTDLPNRFYYQQQLHQYLVNE-ASIQHLAVIRLNIDRFRALNEIISNQAGNELLKQVAQRLRISN
IDALLVAHLSADDFAIIYEMSPLPPIHQLCNNIVEAFSKPFYLADQEYFVSISIGVAIYPEHGRQVDNLNTHAEQALTEAKRLGGNTIRYYSNERANFVA
KYTDLELDLRKAIQNNELVVYYQPKINAHNSHINGFEALIRWKHPTKGLIMPSIFIPLAESTSLISDIGQFVLHEAAKQLQTWQKLGFNNINIAVNIVAQ
QILRGQLLHDIDAVLNTYAISGKNLELEITESAFIENTESVKTVLHAIKERQISIALDDFGTGYSSLAYLTEYPIDILKIDRAFISKIGNAK-QDAIVNA
MIAMGKTIGLKVVAEGVETEQQYEYLKRQNCDILQGYLFSQPLTSAHATEYLQKQMQ---
>tr|N8VRE8|N8VRE8_9GAMM Uncharacterized protein OS=Acinetobacter sp. CIP 102129 GN=F973_01887 PE=4 SV=1
----------------------------------------------------------------------QMNESLEEHRQNLAFAHETAGIRPWEWNLE
THTVGVTNHSQAVT-RKSENHYT----LLHKIVHPDDVDRVKNNLYSHLCGQQRYEETFRIKRHNGEWAWIHDVGQVIRNKDGTPLRMVGIHRDINQEKK
HQERLKLAASVFEHASEGIFILDENFCYIDVNPKYQQLTGLDKQIIINKELEITKQNQHHHNFHLSILDTLYEEQEYEGEFQETYLSEKSCFLWIHINAV
KDETDRVINYIGIVSDQTERKHQEQRLSYLTNYDTLTDLPNRFYYHQQLHQYLVNE-ASIQHLAVIRLNIDRFRALNELLSNQAGNELLKQAAQRLRISN
IDALLVAHLSADDFAIIYEMSPLPQIHQLCNNIVEAFSKPFYIAEQEYVVSISIGVAIYPEHGRQVDNLNTHAEQALTEAKRLGGNTIRYYSSERTNFVA
RHTDLELDLRKAIQNNELVVYYQPKMNALDGKVVGFEALIRWNHPSKGLIMPNIFIPLAESTSLISDIGRFVLYEAAKQLQAWQKLGFNHIKIAVNIVAQ
QIQRGQLLSDLDDILETYAIIGRNLVLEITESAFLENTDTVKMVLKAIKERDISIALDDFGTGYSSLAYLTEYPIDILKIDRAFISKIGDAK-QDAIVNA
MIAMGKTIGLKVVAEGVETEQQRDYLKRQNCDILQGYLFAKPLTAVNATEYLQQHTQ---
>tr|N9F8P6|N9F8P6_ACIHA Uncharacterized protein OS=Acinetobacter haemolyticus NIPH 261 GN=F926_02496 PE=4 SV=1
----------------------------------------------------------------------QMNESLEEHRQNLAFAHETAGIRPWEWNLE
NQTVGVTNHSQAVK-RDSENHYT----LLHKIVHPDDIERVKNALYHHICGELRYEETYRIKRPNGEWSWIHDVGQVIRHEDQTPLRMVGIHRDINQERK
DQERLKLSASVFEQASEGIFILDENFNYIEVNPKYEQITELDKQVILGKQLEITKQNLHHQNFQLSILDTLAHEHEYEGEFQETYHSEKSCFLWMHINAV
KDEQDRVINYIGIVSDQTERKHQEQRLSYLTNYDTLTDLPNRFYYQQQLHQYLVNE-AAIQHLAVIRLNIDRFRTLNELVSNQAGNELLKQVAQRLRISN
IDALLVAHLSADDFAIIYEMSPLPPIHQLCNNIVENFSQPFYIADQEYFVSVSIGVAMFPEHGRQVDNLNTHAEQALNEAKRLGGNTIRYYSNERANLAA
QYSDLELDLRKAIQNNELVVYYQPKMTTHDNLVNGFEALIRWEHPSKGLIMPDIFIPLAESTSLISDIGQFVLHQAAKQLQRWIELGYPQVHIAVNIVVQ
QVLRGQLLHDVDTILSQYKISGHNLELEITESAFLENTETVKTVLEALKDRHISIALDDFGTGYSSLAYLTEYPIDTLKIDRAFISKIGNSK-QDAIVNA
MIAMGKTIGLKVVAEGVETEAQRDYLQKQNCDILQGYLFAKPLTALDATKFLQQHS----
>tr|N8PVK6|N8PVK6_9GAMM Uncharacterized protein OS=Acinetobacter sp. CIP-A165 GN=F991_01720 PE=4 SV=1
----------------------------------------------------------------------QMNESLEEHRQNLAFAHETAGIHPWEWNLE
NQTIGITNHSKPVK-RDSDNHYA----LLHKITHPDDIERVKNTLYGHLYGHARYEETFRIKRPNGEWSWIHDVGQVIRDVNRKPLRMVGVYRDINQERK
DQERLKLSASVFEQASEGIFILDEQFNYVEVNPKYEQMTGLDKQAILNKHLDITKQNPHHQNFQLSILDTLSEEYEYEGEFQETYHSGKSCFLWIHINAV
KNEQDQVINYIGIVSDQTERKHQEQRLSYLTNYDTLTDLPNRFYYQQQLHQYLISD-ASIQHLAVIRLNIDRFRTLNELISNQAGNELLKQVAQRLRVSN
IDALLVAHLSADDFAIIYEMSPLPPIHQLCNNIVENFCQPFYISDQEYLVSISVGVAMFPEHGRQVDNLNTHAEQALNEAKRLGGNTIRYYSNERASLTA
KYSDLELDLRKAIQNNELVVYYQPKIIAQNDQIDGFEALIRWEHPTKGLIMPDIFIPLAESTSLISDIGQFVLHEAAKQLHIWQELGFADIHIAVNIVVQ
QILRGQLLHDIDTILAQYSISGQNLELEITESAFLENTESVKVVLQALKQRHISIALDDFGTGYSSLAYLTEYPIDTLKIDRAFISKIGDAK-QDAIVNA
MIAMGKTIGLKVVAEGVETEQQSEYLKRQNCDILQGYLFARPLTAIHATEYLQQHT----
>tr|N9NLR2|N9NLR2_9GAMM Uncharacterized protein OS=Acinetobacter sp. NIPH 2168 GN=F892_01209 PE=4 SV=1
----------------------------------------------------------------------QMNESLEEHRQSLALAHETAGIQHWDWNLE
NTIPDASPLPHEVA-HNAQNLYT----LLNEVTHPNDVERVKNTLYQHLSGQPRYEETFRIKHENGDWTWIHAVGQVIRDKNGTALRMVGVHRDINQEKK
DQERLKLAANVFEQASEGIFILDENFNYVEINPKYEQLTGLDKQAILGKQLEITKQNQHHHNFHLSILDTLREAQEYEGEFQETYNSEKSCFLWIHINAV
KDEQDRVINYIGIVSDQTERKHQEQRLSYLINYDTLTDLPNRFYYQQQLHQYLVNE-PAIQHLAVIRLNIDRFRALNEIISNKAGNELLKQVAQRLRISN
IDALLVAHLSADDFAIIYEISHLPPIHQLCNNIVEAFSKAFYIADQEYFVSISIGVAIYPEHGRQVDNLNTHAEQALNEAKRLGGNTIHYYSNERANFVD
QYSDLELDLRKAIQNNELVVYYQPKISTLDDQINGFEALIRWKHPTKGLIMPSIFIPLAESTSLISDIGQFVLHEAAKQLQAWQKLGFSNINIAVNIVAQ
QILRGQLLHDIDEVLTTYDISGKNLELEITESAFLENTENVKTILNALKERQISIALDDFGTGYSSLAYLTEYPIDILKIDRAFILKIGNPK-QDAIVNA
MIAMGKTIGLKVVAEGVETEQQRDYLKAQNCDILQGYLFSKPLTATEATEYLQQHLH---
>tr|S3NSW5|S3NSW5_9GAMM Uncharacterized protein OS=Acinetobacter rudis CIP 110305 GN=F945_01020 PE=4 SV=1
----------------------------------------------------------------------EMNNHLMRYRTDLNFTQQNAGVNTWLWDIN
TRQVTISNQFNLNL----RYVNG----QAQFIIHPKDLPLYCKQMRKYLRGQDLFELQYRVKK-NDRWFWIHDVGKITRDINHKPLQMIGIFKGINEEKD
AYEQLRLAANLFNQVTEGLFVLDQNLRYISVNNYYEKLTGLKRCQLLGQPFSTRFTQDLLQTQHDEILKQLSLFGEYRIELQEQYMTGDKQSIGIKINRL
NNIEEPAATYVGNAIDLTERKQHEQRVSYLEQYDLLTDLPNRFYFHYRLNKLINQ--EPPCRFALFRLNIDRFRLFNDLYFNPAGDELLKKFAERLSQYC
NNALLTAYLNNDDFVVAIQTSDSININNLAQGILAAFQEPFFINEQEKCISISIGIAIHPEQGAQVDVLLRKAEAALLKAKQLGGNTYHIFNEQSYEHLN
DKIILRGDLQQALKKQQLTVYYQPQICSTTLKIISFEALIRWQHPKYGLISPNIFIPLAEETSLITEIGQFVIFESCKQLKVWRELGFDDIRVSVNIVAQ
QILRGQLLLDLDTAMAMYQVKGNQLELELIESSLLENSAHVIDFLSKIKERNISISLDDFGMGYSSLAYLSQYPIDKLKIDRAFISRIGDQK-EEAIVNA
IIAMGKAMGMSLIAEGVENDIQLQYLQQHNCDVLQGFYFSKPLTALETTAYLSQYKH---
>tr|N8VBF3|N8VBF3_9GAMM Uncharacterized protein OS=Acinetobacter sp. ANC 3789 GN=F975_02162 PE=4 SV=1
----------------------------------------------------------------------ERTHTLEKQKQTIEMANSIASVHTWEWNLI
KGTFEINNHVKKLE-F--RSLEK----DLTQALHPEDIPLCIEKLHQHFNHEEIFECEYRVKDENDKWVWVINRGKIIYNATSKPMVMIGIFQNIDRQKQ
DHDRIQQAANIMTHVETGIVMLDEQLRYVEANPYFFTLSNLTIEQVLGKQLEITDNYPRQRSFHYSITEQLLKNAEFDGEFEEKFISGKELSLRLRLNAI
RDNKQRIVNYVGIFSDLTKIKQQERRVSYLENYDIVTNLPNRFYYNYKIYQFLITNSDSIHQLAIIRLSIDRFTALYEFLGNQNTSELLKLVAQRLRLSN
PNALMVAYLSRDDFVIVYELNHVPSIQTICEQIRQYFHQAVKIAEQELIITLSIGVAIYPEHASQFEQLNNCAQQALNHARRLGGNTIQYYTKSHDSLYE
KDVNLENELRQALRNQELEVYFQPKIYIHNDQIVGFETLIRWNHPEKGLLHPTQFLPAAQQTSLISDIGEYVLFTAVAQLREWQDQGLPEVFLSINIDAQ
QLYRGQLVEHLDTALNRYQVAGKYVEFEITEASLIENSEYIHNLLHQLKQRHIQLSLDDFGTGYSSMAYLTEFPFDVLKIDKSFVQNMHMKR-HNAIINA
IIAMGKAMDLKIVAEGIETQEQLDFLREKQCDIAQGFYYAKPLNKADASQYLQTFHS---
>tr|V2TJM1|V2TJM1_9GAMM Uncharacterized protein OS=Acinetobacter nectaris CIP 110549 GN=P256_02183 PE=4 SV=1
----------------------------------------------------------------------EYNNLFEKQSSIIELANRTSYIHTWEWNIR
ESKLEVNNFFTNLQ-ND-ATISS----NLGKIIHSNDLKNCLKQLTKHFTKKDFFECQCRVRYE-DQWVWGSLVGKVIVDRNEEPITMLGIFKNIEKEKK
NQDRIEHSSQILQHIDVGIITLDAELNYIDANPFFYTMTGLEKNQVIGKKLDITDDYAQQRSLHYSITDQLFKKSEFKGEFEETFISGRKISIRCHINAV
KDHYQNTLQYVGIFSDLTDYKQQEQRLDYLENYDVTTQLPNRFYYNYKLYQFLINNRETIKKIAIIYLSIDRFSSLQEFLGNKTTSELLRHVAKRLRQLN
PHAFMVAYLNREDFAIVYELNHLPSIQELCGQIITGFTDPFKFADQELILTVSLGVALYPEHALDFDQINYHANHALRQAQNLGGNTVQYYAQDKDNTYT
QNINLENELRQAIKNCELEVYYQPKISLKNNKVSSFEALIRWNHPRRGLLAPVHFLPFAKQTSLISDIGRYVIEASIKQLKSWQSQQLPEVAISINVDPQ
QLYRGQLLHTLDTFLKKYDIHGKYIELEITESSLIEKTLYVQSLLQQLKNRHIALSLDDFGTGYSSLAYLTEFPFDIIKIDRYFVQNMHEKS-QQAVLNA
IIAMGKAMELTIVAEGVETQEQLEFFKQKNCDVIQGYIYSKPLSSSNATVYLKHFSP---
>tr|A4B990|A4B990_9GAMM Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Reinekea blandensis MED297 GN=
----------------------------------------------------------------------QANKRLIQSEEQLNLAMTASGIGFWDWDIP
HRKVYHSDERFFGS-AVDSET-F----SLVDYVAEPDVPQVRRALAKHLRGQEYYQMRYQVFLPTAQPRWIEDIGKVTRDARGRPIRMIGTRRDVTKDMQ
LQEELSLSSSLFNNSADGVFVLDQHQQFRTCNRVFCDIFGRQKGELLGLPLQVIRTD-----QTQRISQSMISNGRWSGDLFSQRRGGERFPMTMTLTTI
RREDNSVSHYLGICRDQSESQRTEKELRYLNNYDKLTGLYNRGYFHEIVGQFREHEPLLTEHYAVCVINLDRFKSVNESLGLEVGDQLLKDLAARLNNLQ
EPIRQVARLSSDEFAMIIEFEQDDMLLSMLEHLQAEITRPFLVGEHELIVTASIGVCVVTEGN--LTQLLNHAIAAMNQARYQGGNNYQFYHQRLATTPL
ERLQLEKALRKAVINNEFSVDYQPKMNLHTGIIDSVEALVRWRHPHKGVLDPDDFIPLAEETGLISAIGEQVLNKACQEAAAWRQRGFGDISISVNLSSH
QIRRNDLYDIIYNALQNSQLPAEYLELELTESMLMEDISHAQDFLNQLRSLGVRLALDDFGTGYSSLSYLKRLPIDTLKIDRSFVAEARQGE-TSPIVEA
VMAMSESLRLNVVAEGVETREQLHYLESLGCDYAQGYIISRPLPASEVLTLIRHSNL---
>tr|Q2SNY4|Q2SNY4_HAHCH Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Hahella chejuensis (strain KCT
----------------------------------------------------------------------EANRILMKSQTRLSQAIEATGLALWDWDIP
RNSLYQSFHDAFGE-MSATAFVE----RMHGLIHTDDRPRIRKEMMLCLKGLNTYRVQYRVTTA-DAWIWVEDCGKPVFDKLGRITRMIGSRRDISKEKS
RDEQLLLAKSVFDHTPQGVFALDTEFRFLTVNNAFSQITGYETEEVIGSSLDFSQAPK--RQVFSRIRDELFLRGRWQGELYEKRKSGEFYCQWLQITSI
INTEGATTHYAGLFSDLTERKQADEKLHYLLNYDELTGLANRMLFRERLDKILRKVREQGLSINMLLLNVDRFRQVNESLGQDRGDELLKQVATRISQTA
SHAHTLARLGSDEFAILTPAK-SSQISRFCEQLLDELKAPFNIDGHEFYVSTSIGVTQAPDNGWEIQTLMQQANMAVRQAKYLGGNTYEFYSRMLRSMSR
MRLDVETELRRAIQNQQMEVFFQPKLSLDSGRITGVEALARWRHPQRGLIAPSDFVPMAEESGLITELGEQMLGAACAQAAAWSREGLDNIQVSVNLSAH
QLRQSNLPQMVRKVLQDTELPPHLLDLELTESTLMENMSRTQFMLSRLREMGVRITVDDFGTGYSSLSYLKRFPLNALKIDRMFIKDAHHNADDAAITRA
VIMLGKSLNLEVIAEGVEHEGHLQFLRESGCHTVQGYLIAEPLGAEQMASLLREQSV---
>tr|A0A089YV61|A0A089YV61_9PSED Strain DSM 16299, complete genome OS=Pseudomonas rhizosphaerae GN=LT40_19670 PE=4 SV=1
--------------------------------------------------------------VT--SHR-TASESLRQSEKRHRMLAESISDVIFSTNNR
LELNYVSPSVQTVLGFDADWVLQNG--WQSMLANPAQMTGINALLAQALRSDKTQVFMFDCLRHDGRKIPIELRLVLIWDAQGMFEGILGVGRDVSQQRR
AEKDLRMAATVFEHSTSAILITDPAGYIVQANEAFSRVSGYAVAQVLDQLPNMLTVDDQQEAHLRYVLKQLQLRGTWEGEVWLKRRNGEHYPAWVGITAV
LDDEGDLASYVCFFSDISERKASEQRIHRLAYYDALTHLPNRTLFQDRLYNALQQAERQQSWVVLMFLDLDRFKPINDSLGHAAGDRMLKDMATRLLGCV
DDDDTVARMGGDEFTLLLQPRATELAIHVAEQILGSLVKPFVLEGREFFVTASVGIALSPQDGGELSQLMKNADTAMYHAKERGKNNFQFYQADMNATAL
ERLELESDLRHALEQEEFVLYYQPQFSGDGKRLTGAEALLRWNHPRRGLVPPGEFIPVLEELGLVVDVGDWVLAEACRQLKAWHVAKVRVPKVSVNISAR
QFADGQLGKRIARTLESIGLPPACLELELTESILMREVNEALVILDTLKNLGLSIAIDDFGTGYSSLNYLKQFPIDVLKIDRTFVDGLPSGEQDAQIARA
IIAMAHSLNLSVIAEGVETHEQLEFLREHGCDEVQGYLFGRPMQAHRFEAQFSNDAL---
>tr|J2YQX4|J2YQX4_9PSED Developmental regulator MorA OS=Pseudomonas chlororaphis subsp. aureofaciens 30-84 GN=morA PE=4 SV=1
--------------------------------------------------------------IT--SRKLEASESLRDSERRYRMLAESISDVIFSTDSK
MALNYVSPSVQSVLGYDVEWIFQNG--WQSTIANPQQLTGIYALMERRLRNQQTQLFLFDCLRADGRKIPIELRLVLVWDELGAFEGVLGVGRDISQQRR
AEKDLRMAATVFEHSTSAILITDPAGYIVQANEAFSRVSGYAVSQVLDQLPNMLTVDEQQEAHLRYVLKQLHQHSTWEGEVWLKRRNGEHYPAWVGITAV
LDDEGDLASYVCFFTDISERKASEQRIHRLAYYDALTHLPNRTLFQDRLHTALQSAERQKSWVVLMFLDLDRFKPINDSLGHAAGDRMLKEMATRLLDCV
DDDDTVARMGGDEFTLLLQPRTSEIAIHVAEQILASLVKPFVLEGREFFVTASIGIALSPQDGNELSQLMKNADTAMYHAKERGKNNFQFYQADMNASAL
ERLELESDLRHALEQQEFILYYQPQFSGDGKRLTGAEALLRWRHPRRGLVPPGDFIPVLEELGLVVDVGDWVISEACRQLKAWHQAKVRVPKVSVNISAR
QFSDGQLGMRIATILKDTGLPPACLELELTESILMREVSEAMQILDGLKNLGLSIAVDDFGTGYSSLNYLKQFPIDVLKIDRTFVDGLPSGEQDAQIARA
IIAMAHSLNLAVIAEGVETHEQLDFLREHGCDEVQGYLFGRPMPANSFEGQFSNDAL---
>tr|S6HCS8|S6HCS8_9PSED Sensory box/GGDEF domain/EAL domain protein OS=Pseudomonas sp. CFII64 GN=CFII64_11986 PE=4 SV=1
--------------------------------------------------------------IT--RRKQEASESLRDSEQRYRMLAESISDVIFSTDSQ
LKPNYVSPSVNTVLGYSAEWILENG--WDKTFANPAQLADMYALLARKLRLEPTQLFLFDSLRADGRKIPIELRLVLVWDDRGVFEGILGVGRDVSQQRR
AEKDLRMAATVFEHSTSAIIITDPAGYIVQANEAFSRVSGYEVAQVLDQLPTMLTVDEQQEAHLRYIVKQLHQRRSWEGEVWLKRRSGEHYPAWVGINAV
LDDEGDLASYVCFFSDISERKASEQRIHRLAYYDALTHLPNRTLFQDRLHSALQQAERQQSWVVLMFLDLDRFKPINDSLGHAAGDRMLQEMATRLLACV
ADDDTVARMGGDEFTLLLQPGATQLAINVAEKILTSLVTPFVLEGREFFVTASIGIALSPQDGNELSQLMKNADTAMYHAKERGKNNFQFYQADMNASAL
ERLELESDLRHALEQKEFTLYYQPQFSGDGKRLTGAEALLRWRHPRRGLVSPNEFIPVLEELGLVVEVGDWVLAEACRQLKAWHVAKVRVPKVSVNISAR
QFSDGQLGTRIANILKESGLPPACLELELTESILMREVSEAMQILDGLKCLGLSIAVDDFGTGYSSLNYLKQFPIDVLKIDRTFVDGLPSGEQDAQIARA
IIAMAHSLNLAVIAEGVETHEQLEFLREHGCDEVQGYLFGRPMPPGRFEAQFSNDAL---
>tr|A5VYA7|A5VYA7_PSEP1 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudomonas putida (strain F1 / ATCC 700007) GN=Pput_0703 PE=4 
--------------------------------------------------------------IT--SRKQEASQSLRDSEQRYRMLAESISDVIFSTDNQ
LKLNYVSPSVQSVLGYQADWIFANG--WQSIVANPAQLTGIYSLMERQLCSQPTQLFLFDCLRADGRKIPIELRLVLVWDDDQRFEGVLGVGRDISQQRR
AEKDLRMAATVFEHSTSAILITDPAGYIVQANEAFSRVSGYAVSEVLDQLPGMLTVDEQQEGHLRYVVKQLHQRGSWEGEVWLKRRDGDHYPAWVGITAV
LDDEGDLASYVCFFTDISERKASEQRIHRLAYYDALTHLPNRTLFQDRLYNALQQAERQKAWVVLMFLDLDRFKPINDSLGHAAGDRMLKDMALRLLACV
DDDDTVARMGGDEFTLLLQPRPTEMAIHVAENILGSLVRPFVLENREFFVTASIGIALSPQDGSELSQLMKNADTAMYHAKERGKNNFQFYQAEMNASAL
ERLELESDLRHAMEQNEFILYYQPQFSGDGKRLTGAEALLRWRHPTRGLVPPGDFIPVIEELGLVVDVGDWVLREASRQLKAWHKAKVRVPKVSVNISAR
QFSDGQLGTRIANILEESGLPPACLELELTESILMREVNEALQILASLKNLGLSIAVDDFGTGYSSLNYLKQFPIDVLKIDRTFVDGLPEGEQDAQIARA
IIAMAHSLNLAVIAEGVETHEQLEFLREHGCDEVQGYLFGRPMPAHQFEAQFSNETL---
>tr|A0A098SVN5|A0A098SVN5_9PSED Diguanylate phosphodiesterase OS=Pseudomonas lutea GN=LT42_23345 PE=4 SV=1
--------------------------------------------------------------FT--NRKQEASQSLRESEQRYRMLAESISDVIFSTDRH
LQANYFSPSVNTVLGYSGEWIMQHG--WKGIIANPQQLSSFMALLRRDLRRETTQLFMFDCLRADGRKIPVELRLVLVWHESGTFEGVLGVGRDVSQQRR
AEKDLRMAATVFEHSTSAILITDPAGYIVQANDAFTRVSGYAVAQVVDQLPMMLTVENQQGAHLGYILKQLSQRGSWEGELWLKRRAGEHFPAWVGITAV
LDDEGDLASYVCFFSDISERKASEQRIHRLAYYDALTHLPNRTLFQDRLHTALQHAERQQAWVPLMFLDLDRFKPINDSLGHAAGDRMLKEMATRLLACV
TDDDTVARMGGDEFTLLLQPRATQAAIHVAEQILASLVTPFVLEGREFFVTASIGIALSPQDGNELSQLMKNADTAMYHAKERGKNNFQFYQTDMNASAL
ERLELESDLRHALEQGEFTLYYQPQFSGDGKRLTGAEALLRWRHPRRGLVPPGDFIPVLEELGLVVEVGEWVLKEACRQLREWHLARVRVPKVSVNISAR
QFSDGQLGTRIASILEEIGLPPACLELELTESILMREVSEAMHILAGLKRLGLSIAVDDFGTGYSSLNYLKQFPIDVLKIDRTFVDGLPSGEQDAQIARA
IIAMAHSLNLAVIAEGVETQEQLEFLREHGCDEVQGYLFGRPMPATRFEAQFSNDAL---
>tr|A0A089WLC9|A0A089WLC9_9PSED Diguanylate phosphodiesterase OS=Pseudomonas cremoricolorata GN=LK03_09000 PE=4 SV=1
--------------------------------------------------------------IT--SRKQEASESLRDSEQRYRMLAESISDVIFSTDSQ
LKLNYVSPSVKVVLGYEVEWIFSNG--WQSTIANPAQLSGVLKLVEQRLHSDPTQLFVFDCLRADGRKIPIELRVVLVWDEHGGFEGILGVGRDISQQRR
AEKDLRMAATVFEHSTSAILITDPAGYIVQANEAFSRVSGHAVSDVLDQLPGMLVVDNQQEAHLRYVLKQLHQRGSWEGEVWLKRRSGEHYPAWVGITAV
VDDEGDLASYVCFFTDISERKASEQRIHRLAYYDALTHLPNRTLFQDRLYTALQQAQRNTSWVVLMFLDLDRFKPINDSLGHAAGDRMLKDMAERLLACV
HDDDTVARMGGDEFTLLLQPRPSEAAIHVAENILASLVRPFVLENREFFVTASIGIALSPQDGSELSQLMKNADTAMYHAKERGKNNFQFYQADMNASAL
ERLELESDLRHALEQKEFVLYYQPQFSGDGKRLTGAEALLRWRHPRRGLVPPGEFIPVLEELGLVVEVGDWVLREACRQLQIWREARVRVPKVAVNLSAR
QFSDGQLGTRIAGILQETGLSPGCLELELTESILMREVDEAMQMLASLKQLGLSIAVDDFGTGYSSLNYLKQFPIDVLKIDRTFVDGLPCGEQDAQIARA
IIAMAHSLNLTVIAEGVETHEQLEFLREHDCDEVQGYLFGRPMSAHQFEAQFSNEAL---
>tr|A0A077LBI3|A0A077LBI3_9PSED Sensory box/GGDEF domain/EAL domain-containing protein OS=Pseudomonas sp. StFLB209 GN=PSCI_1043 PE=4 SV=1
--------------------------------------------------------------IT--SRKQTASQSLRDSEQRYRMLAESISDVIFSTDRG
LELNYVSPSVETVLGYSADWIVRNG--WSAALANPQQLTGIYSLIVRRLRNEPTRQFVFDCLRADGRKIPIELRLVLVWDEHGSFEGILGVARDVSQQRR
AEKDLRMAATVFEHSTSAILITDPAGYIVQANDAFTRVSGYEVHQILDQLPTLLTVEHE-EAHLHQVLRHLNQRGNWEGEVQLKRRNGEQYPAWVGITAV
LDDEGDLASYVCFFSDISERKASEQRIHRLAYYDALTHLPNRTLFQDRLHSALQQAERQSAWVVLMFLDLDRFKPINDSLGHAAGDRMLKEMASRLLACV
TDDDTVARMGGDEFTLLLHSGATEVAIHVAEQILNSLVTPFVLEGREFFVTASIGIALSPQDGHELSQLMKNADTAMYHAKERGKNNFQFYQADMNATAL
ERLELESDLRHALEQEEFVLYYQPQFSGDGKRLTGAEALLRWRHPRRGLVPPNDFIPVLEELGLVMEVGDWVLAEACRQLKTWHQERVRVPKVSVNISAR
QFGDGQLGERIAATLRDTGLPPACLELELTESILMREVGEAMQTLAGLKNLGLSIAVDDFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPSGEQDAQIARA
IIAMAHSLNLSVIAEGVETHEQLDFLREHGCDEVQGYLFGRPMPAGQFEAQFSNDAL---
>tr|S6HXE7|S6HXE7_9PSED Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudomonas sp. CF149 GN=CF149_06469 PE=4 SV=1
--------------------------------------------------------------IT--SRKLEASESLRDSEQRYRMLAESISDVIFSTDST
LRMNYLSPSIQTVLGYDAQWVFDHG--WQSIIATPQQLEGIYNLIERALRAQQTQLFLFDCLRADGHKVPIELRLVLVWDENDGFEGILGVGRDISQQRR
AEKDLRMAATVFEHSTSAILITDPAGYIVQANEAFSRVSGYAVAQVLDQLPSMLTVDAQQRAHLTYVLKQLHVHGTWEGEVWLKRLNGEHYPAWVGITAV
LDDEGDLASYVCFFSDISERKASEQRIHRLAYYDALTHLPNRTLFQDRLHTALQQAERNKSWVVLMFLDLDRFKPINDSLGHAAGDRMLKDMAIRLLACV
GDDDTVARMGGDEFTLLLQPRSTQLAISVAEQILASLVKPFVLESREFFVTASIGIALSPQDGNELSQLMKNADTAMYHAKERGKNNFQFYQADMNASAL
ERLELESDLRHALEQQEFILFYQPQFSGDGKRLTGVEALLRWNHSRRGLVPPGDFIPVLEELGLVVEVGDWVLAEACRQLKLWHQAKVRVPKVSVNISAR
QFSDGQLGTRIANILKETGLSPACLELELTESILMREVSEALHILASLKNLGLSIAVDDFGTGYSSLNYLKQFPIDVLKIDRTFVDGLPSGEQDAQIARA
IIAMAHSLNLAVIAEGVETHEQLDFLREHGCDEVQGYLFGRPMPAHLLVKQLRAASD---
>tr|A0A0D0MRS4|A0A0D0MRS4_PSEVI Strain LMCA8 contig_25, whole genome shotgun sequence OS=Pseudomonas viridiflava GN=RT94_12820 PE=4 SV=1
--------------------------------------------------------------IT--SRKQTSSQSLRDSEQRYRMLAESISDVIFSTDNQ
LEPNYVSPSVQSVLGYTADWILAHG--WGVTVANPQQLTGFDALIRNKLRNDTPRLFVFDCLRADGRKVPVELRMVLVWDEHDNFEGLLGVGRDISQQRR
AEKDLRMAATVFEHSTSAILITDPAGYIVQANEAFTRVSGYEVAQVLDQLPGMLTVEAEQEAHLRYVIRQLNQSGTWEGEVRLKRRNGEHYPAWVGITAV
VDDEGDLASYVCFFSDISERKASEERIHRLAYYDALTHLPNRTLFQDRLHSALQQAERQQAWVVLMFLDLDRFKPINDSLGHAAGDRMLQEMATRLLACV
TDDDTVARMGGDEFTLLLQPGPTESAIHVAEKILNSLVTPFVLEGREFFVTASIGIALSPQDGDELSQLMKNADTAMYHAKERGKNNFQFYQADMNASAL
ERLELESDLRHALEQQEFTLYYQPQFSGDGKRLTGTEALLRWRHPRRGLVPPNDFIPVLEELGLVVEVGDWVLTEACSQLKKWHQAKVRVPKVSVNISAR
QFSDGQLGKRIASILHTIGLPPACLELELTESILMREVNEAMQILDGLKNLGLSIAVDDFGTGYSSLNYLKQFPIDVLKIDRTFVDGLPSGEQDAQIARA
IIAMAHSLNLAVIAEGVETQEQLDFLREHGCDEVQGYLFGRPMPASQFEAQFSNDAL---
>tr|A0A0A1YQM9|A0A0A1YQM9_9PSED Diguanylate cyclase OS=Pseudomonas taeanensis MS-3 GN=TMS3_0106695 PE=4 SV=1
--------------------------------------------------------------IT--SRKRESSESLRDSEQRSRLLAESISDVIFSTDDS
LQLSYVSPSVESVLGYTTEWVLANN--FQGMTTNPQQLTGLFRLLERELRQQQPQLLVFDCLRADGHKIPVELRVVPMWDAHGRFEGLLGVGRDISQQRR
ADKDLRMAATVFEHSTAAILVTDPAGYIVQVNKAFSRVCGYSSAQVLDQLPGMLTADHQQASHLHYILGQLNQRGSWEGEVWLKRRNGESFPAWVGITAV
QDEEGDLVSYVCFFSDMSERKASEQRIHRLAYYDALTLLPNRTLFQDRLHTALLHAERHQEWVVLMFLDLDRFKPINDSLGHAAGDRMLKDVAIRLAAGV
DDDDTVARMGGDEFTVLLQSHSTEGAIHVAEQILASLAQPFILEGREFFVTASIGIALSPQDGNELSHLMKNADTAMYHAKERGKNNFQFYQADMNASAL
ERLELESDLRHALEQDEFILHYQPQFSGDGKRLTGVEALLRWQHPRRGLVPPDDFIPVLEELGLVVQVGDWVLAEACRQLKSWHAAKVRVPKISVNLSAR
QFTEGDLDSRIAAILEHSGIPPACLELELTESTLMQDVASAMQTLADLKRLGLCIAIDDFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPQGEQDGQIACA
IIAMAHSLNLTVIAEGVETQAQLDFLRIHGCDEVQGYLLGHPMSARRFAAQFSGAAL---
>tr|U1ZAY3|U1ZAY3_9PSED Diguanylate cyclase OS=Pseudomonas sp. EGD-AK9 GN=N878_07980 PE=4 SV=1
--------------------------------------------------------------IT--SRKRERNQSLRDSEQRYRLLAESISDVIFSTDDS
LALNYVSPSVEPVLGYSVDWVMANS--FSSMAANPQQLNGLNLLLERRLREEPDQLFVFDCLRADGHKIPVELRLVLMWDENGRFEGILGVGRDISQQRR
AEKDLRMAATVFEHSTAAILVTDPAGYIVQVNKAFSRVSGYSAGQVLDQLPGMLTADRQQAAHLQYILGQLNQRGSWEGEVWLKRKGGENFPAWVGITAV
HDEEGDLVSYVCFFSDISERKASEQRIHRLAYYDALTHLPNRTLFQDRLHSALQHAERHDEWVVLMFLDLDRFKPINDSLGHAAGDRMLKDVAIRLSACV
DGDDTVARMGGDEFTLLLQPRATEGAIHVAEQILSSLARPFVLEGREFFVTASIGIALAPQDGEELSQLMKNADTAMYHAKERGKNNFQFYQADMNASAL
ERLELESDLRHAQEQGQFVLHYQPQFSGDGRRLTGVEALLRWNHPRRGLVPPDEFIPVLEELGLVVQVGDWVLDEACRQLKAWHEEKIRIPKISVNLSAR
QFAEGDLHTRIAAILAGSGIPPACLELELTESILMRDVASAMQTLADLKRLGLCIAVDDFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPEGEQDAQIARA
IIAMAHSLNLAVIAEGVETQAQLDFLRMHECDEVQGYLLGRPMRAQQFSAQFGNTAL---
>tr|A0A0D6SAB4|A0A0D6SAB4_9PSED Sensory box/GGDEF domain/EAL domain protein OS=Pseudomonas sp. FeS53a GN=SZ55_4025 PE=4 SV=1
--------------------------------------------------------------IT--SRKREASEQMRDSERRYRLLAESISDVIFTSDRE
LKLNYISPSVQPVLGLSPEWVIDHG--FNGTVANPRQLASLFVLMDKELRSQPPQLFLFDCLRADGRKIPVELRIMLMWDEHGRFEGLLGVGRDISQQRR
AEKDLRMAATVFEHSTSAILVTDPAGYIVQVNEAFTRITGYQSAEMLDQLPSMLTADRQQATQLDYILRQLNQRGSWEGEIWLKRRAGDHYPAWVGITAV
HDEEGDLVSYVCFFSDISERKASEQRIHRLAYYDALTQLPNRTLFQERLHTALQHAERREEWVVLMFLDLDRFKPINDSLGHAAGDRMLKDVAVRLADCV
GDDDTVARMGGDEFTLLLSPCTGETAITVAEQILSRLARPFVLEGREFFVTASIGIALGPQDGHEPSQLMKNADTAMYHAKERGKNNFQFYQAEMNARAL
ERLELESDLRHALEQREFVLYYQPQFSGDGKRLTGVEALLRWRHPERGLVPPGEFIPVLEELGLVVEVGDWVLREACRQLRAWHQRKMRLPKVSVNISAR
QFADGQLVQRISGILAESGLPPACLELELTESILMRDVAEAMEILANLKRLGLCIAVDDFGTGYSSLNYLKRFPIDVLKIDRSFVDGLPDGERDAQIARA
IIAMSHSLNLAVIAEGVETHAQLDFLREHGCDEVQGFLFGRPMPADQLEAQFGGAAL---
>tr|S6AMD0|S6AMD0_PSERE Uncharacterized protein OS=Pseudomonas resinovorans NBRC 106553 GN=PCA10_09060 PE=4 SV=1
--------------------------------------------------------------IT--SRKEEATESMRESGRRYRMLAESISDVIFTTDSE
LQLSYVSPSVLPVLGYSAEWTIANG--FQGMSADPRQMVNLFEQLEHELRTQPARLFLFDCMRADGQKIPVELRTMLMWDEYGRFEGMLGVGRDVSQQRR
AEKDMRMAATVFEHSTSAILVTDPAGYIVQVNEAFCRITGHAASEVLDQLPAMLTADRQQANQLTFIISQLNQRGSWEGEIWLKRREGDSYPAWVGITAV
HDEEGDLVSYVCFFSDISERKASEQRIHRLAYYDGLTHLPNRTLFQDRLHTALQYAERNQEWVVLMFLDLDRFKPINDSLGHAAGDRMLKDVAVRLATCV
HEDDTVARMGGDEFTLLLQPRATEGAIHVAEQILGNLARPFVLEGREFFVTASIGIALSPQDGRELSQLMKNADTAMYHAKERGKNNFQFYQADMNARAL
ERLELESDLRHALEQGEFLLYYQPQFSGDGKRLTGVEALLRWRHPKRGLVPPSEFIPVLEELGLVVQVGDWVLAEACRQLKTWHQAKMRLPKISVNLSAR
QFADGQLAERIAAIIDDCGLPPACLELELTESILMRDVGEAMAILENLKRLGLCIAVDDFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPDGERDAQIARA
IIAMAHSLNLAVIAEGVETPAQLGFLREHGCDEVQGYLFGHPMPAVQFERLFGAATD---
>tr|A0A0D0KK60|A0A0D0KK60_9PSED Strain MEJ086 contig_41, whole genome shotgun sequence OS=Pseudomonas fulva GN=RU08_15600 PE=4 SV=1
--------------------------------------------------------------IT--SRKRARNESLRDNEQRYRMLAESISDVIFSTDSQ
LTLNYISPSVQTVLGYPPQWVQQHG--FEGLATNPQQLGGIYALLERELRQTTPQLFVFDCLRADGRKIPVELRLVPMWDDNGHFEGLLGVGRDIAQQRR
AEKDLRMAATVFEHSTAAILVTDPAGYIVQVNNAFSRVSGYSSEQVLDQLPGMLTADSQQSKHLQYVLAQLNQRGTWEGEIWLKRRNGENFPAWVGITAV
HDEEGDLVSYVCFFSDISERKASEQRIHRLAYYDALTQLPNRTLFQDRLHTALQHAERHREWVVLMFLDLDRFKPINDSLGHAAGDRMLKDVAVRLAACV
GEDDTVARMGGDEFTLLLQSNSTQGAIHVAEQILASLARAFVLEGREFFVTASIGIALSPQDGNELSQLMKNADTAMYHAKERGKNNFQFYQADMNASAL
ERLELEGDLRHALEQGEFLLHYQPQFSGNGKRLTGVEALLRWQHPKRGLVAPDAFIPVLEELGLVVQVGDWVLAEACRQMNIWHHNKIRVPKVSVNLSAR
QFSDGHLHQRIARTLSACNIPAACLELELTESILMQDVGAAMQTLKDLKNLGLCIAIDDFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPQGEQDGQIARA
IIAMAHSLNMTVIAEGVETQEQLDFLRNHECDEVQGYLLGRPMPAHQFEAQFCGRSL---
>tr|F3HRA7|F3HRA7_PSEYM Sensory box/GGDEF domain/EAL domain-containing protein OS=Pseudomonas syringae pv. maculicola str. ES4326 GN=PMA4326_24006 PE=4
--------------------------------------------------------------IT--SRKQASSQSLRDSEQRYRMLAESISDVIFSTDNQ
LRPNYVSPSVESILGYSPDWILENG--WAGAIATQQQLSGFYALMSRSLRSETTRLFLFDCLRADGRKIPVELRVVLVWDEHDNFEGILGVGRDISQQRR
AEKDLRMAATVFEHSTSAILITDPAGYIVRANEAFTRVSGYEVAQVVDQLPSMLTVEAEQEAHLRYIIRQLSGRGTWEGEVRLKRRNGEHYPAWVGITAV
VDDEGDLASYVCFFTDISERKASEDRIHRLAYFDALTHLPNRTLFQDRLYSALQQAERQQAWVGLMFLDLDRFKPINDSLGHAAGDRMLQEMATRLLACV
DVNDTVARMGGDEFTLLLQQGSTEEAIHVAERILTSLVTPFVLEGREFFVTASIGIALSPQDGKELSQLMKNADTAMYHAKECGKNNFQFYQADMNATAL
ERLELESDLRHALEQQEFTLYYQPQFSGDGKRLTGAEALLRWRHPRRGLVPPNEFIPVLEELGLVVEVGDWVLTEACRQLKHWHQHKVRVPKVSVNISAR
QFSDGQLGKRIATILEQTGLSPACLELELTESILMREVNEAMQILDGLKNLGLSIAVDDFGTGYSSLNYLKQFPIDVLKIDRTFVDGLPSGEQDAQIARA
IIAMAHSLNLSVIAEGVETHEQLEFLREHNCDEVQGYLFGRPMPPKQFEAQVPGLVD---
>tr|A0A0D7FCI2|A0A0D7FCI2_9PSED Diguanylate cyclase OS=Pseudomonas oryzihabitans GN=UM91_11425 PE=4 SV=1
--------------------------------------------------------------IT--QRKLRASERLRESENRYRQLAESISDVIFTTDAQ
LVLNYLSPSVEELLGYPVAELQQRT--LAELVVHSRQLQEFRRTLQRELRREFA-PLLLDCLHAQGHTLQIELRLKPLWDDHERFAGLLGICRDISAQRR
TEKDMRMAATVFDHSAGAILVTDPAGYIVRVNRTFTRITGFSPEEVFDQQPMMLCADKQEANQLQHVMQQLRTQESWEGELWQRRQDNEPYPSWVGITAI
RDDDGDLMSYVCFFVDISERKASERRIHRLAYYDALTLLPNRTLFQDRLHNALQQSRHNGSWVVLMFLDLDRFKPINDSLGHAAGDRLLKEVAMRLTACV
GTEDSVARMGGDEFTLLLSGLETEVAIRVGEQILTQLSEAFVLEGREFFVSASIGIALSPQDGHELSQLMKNADTAMYHAKEMGKNNFQFYQAEMNARAL
ERLELEADLRHALLQGEFRLHYQPQYRCDNRRLTGVEALLRWEHPVRGHVSPAEFIPVLEEIGLVVQVGDWVIREACRQMREWHAARVRIPKVSVNLSAR
QFSDGQLGQRIAAILAETGLAPACLELELTESILMRDVGEALQLLGELKSLGLCIAVDDFGTGYSSLNYLKQFPIDILKIDRSFVDGLPHGEQDAQIARA
IIAMAHSLNLSVIAEGVEEPAQLEFLRLHGCDEVQGFLFDRPLPPDLLRERLEHQGL---
>tr|N2J0Q8|N2J0Q8_9PSED PAS domain S-box protein OS=Pseudomonas sp. HPB0071 GN=HMPREF1487_06986 PE=4 SV=1
--------------------------------------------------------------VS--RRKRNANDLLRDQERRYRLLAESISDIIFSTDQQ
LAINYISSSAENLLGYKLETLYQLN--PYDLATHSQQLKKLRDWIKKEVDQESSQVIILDCLHADGHKLSLEMRLETLWDKHGRFEGLLGICRDITAQRR
AEKDMRMAATVFDHSAAAILVTDPAGYIVRVNQMFTRMTGYEPEEVIDQQPRMLCADLQEANQLSHIMNHMAVQGSWEGELWQKRKDGEPYPSWIGITGV
RDDEGDLVSFVCFFVDISERKASERHIHRLAYYDALTLLPNRTLFQDRLHTALEQAVHHASWVVLMFLDLDRFKPINDSLGHAAGDRMLKEVAVRLTACV
GTEDSVARMGGDEFTLLLANLGSEEAIRVAENILESLSEAFILENREFFVSASIGIALSPQDGSELSQLMKNADTAMYHAKEMGKNNFQFYQAEMNARAL
ERIELEADLRHALLQNEFTLHYQPQYRCSNGQLTGLEALLRWSNPRRGNVSPVDFIPVLEETGLIIQVGDWVIKEACRQLRVWHDEKVRIPKVSVNLSAR
QFADNRLGEHIAQILQEVGLPPACLELELTESILMQNVDDALMTLKSLKELGVCISVDDFGTGYSSLNYLKQLPIDILKIDRSFVDGLPHGEQDAQIARA
IIAMAHSLNLSVIAEGVENEEQLKFLRDHECDEVQGYLFDKPLSPELIEARLRLM-----
>tr|A0A081Y2N4|A0A081Y2N4_9PSED Diguanylate cyclase OS=Pseudomonas sp. AAC GN=FG99_31095 PE=4 SV=1
--------------------------------------------------------------IS--SRKQEANNSLRESSRRYQMLAESISDVILTTDAQ
LNIDYISPSIEQTFGYSPAWLLHND--LQQIAANPAQLGRLHDLLERALRESAVHLFTFDCLRADGRKVPVELRIALMWDDNGRFVGLLGVARDISQQRR
AEREMRMAATVFEHSTAAIMVTDPAGYIVQVNDSFSRLTGYSAAEVLDQQPRLLTADQQEANQLKHVLDSLQRSGSWEGEILQKRKSGELYPSWVGITAV
QDEEGDLVSFVCFFSDISERKASERRIHRLAYYDALTHLPNRTLFQDRLHTALMQAERHRQWVVLMFLDLDRFKPINDSLGHAAGDRMLKEVAERLNQCV
SDNDTVARMGGDEFTLLLPGLEDERAIQVAERILASLARPFTLEGREFFVTASIGVALSPQDGAELSQLMKNADTAMYHAKEVGKNNFQFYQAEMNARAL
ERLELESDLRRAIEQDEFVLHYQPQFTGDGRRLTGAEALLRWQHPTRGLIAPAEFIPVLEELGLIAQVGDWLLAEACRQIRIWHRDKVRVPKVSVNLSAR
QFADGQLGTRIAGILMETGIPPACLELELTESILMSDVSEAMHILSGLKRLGLAIAVDDFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHGEQDAQIARA
IIAMAHSLNLMVIAEGVESQAQLDFLREHGCDEVQGFLFGRPMTAEQFAALFSSNAL---
>tr|W1MNP2|W1MNP2_PSEAI Diguanylate cyclase OS=Pseudomonas aeruginosa VRFPA03 GN=M770_04510 PE=4 SV=1
--------------------------------------------------------------VT--SRKEEANNALRENGRRYRMLAENISDVIFSTDAE
LNASYVSPSVQHVFGYSPEWALLNG--LHQTATNPRQLGRLNGLLRRELRENGQHLFALDCLRADGRKIPIELRIVLMWDEHDRFEGLLGIARDISQQRR
AERELRMAATVFEHSTAAIMVTDPAGYIVQVNDSFSRLTGYSPADVLDQQPRLLTADRQEANQLKHVLASLQHSGSWEGEILQKRKTGELYPSWVGITAV
RDEEGDLVSFVCFFSDISERKASERRIHRLAYYDALTHLPNRTLFQDRLHTALQQAERNGQWVVLMFLDLDRFKPINDSLGHAAGDRMLQEVATRLSACV
SQDDTVARMGGDEFTLLLPSQGDEIAIQVAELILGRLARPFTLEGREFFVTASIGVALSPQDGAELSLLMKNADTAMYHAKEMGKNNFQFYQAEMNARAL
ERLELESDLRRALELGEFVLHYQPQFTGDGRRLTGAEALLRWQHPRRGLVPPSEFIPVLEEIGLVAQVGDWLLAEACKQLRSWHKAKVRVPKVSVNLSAR
QFADGQLGERIAAILYETGIPPACLELELTESILMSDVAEAMQILSGLKRLGLAIAVDDFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHGEQDAQIARA
IIAMAHSLNLMVIAEGVESQAQLDFLREHGCDEVQGYLFGRPMPAEQFGMLYASDVL---
>tr|M4WRN7|M4WRN7_PSEDE Motility regulator OS=Pseudomonas denitrificans ATCC 13867 GN=H681_04355 PE=4 SV=1
--------------------------------------------------------------IT--SRKQEAHNSLRESGRRYRMLAESISDVIVSTDAQ
VRLNYVSPSIQQVFGYNAEWVRQNG--FQQVAANPAQLERLTALLERELRENEPQLFTLDCIHADGHKIPVELRIALMWDDHGCFEGLLGVARDISQQRR
AEREMRMAATVFEHSTAAIMVTDPAGYIVQINDSFSRLTGYCAEEVLDQLPRLLTADRQEANQLKHVLDSLRKSGSWEGEILQKRKNGELYPSWVGITAV
HDEEGDLVSFVCFFSDISERKASERRIHRLAYYDALTHLPNRTLFQDRLHTALLQAERHQQWVVLMFLDLDRFKPINDSLGHAAGDRMLKEVAERLSHCV
SDDDTVARMGGDEFTLLLPGQADERAIQVAEQILASLARPFTLEGREFFVTASIGVALSPQDGAELSQLMKNADTAMYHAKEMGKNNFQFYQAEMNARAL
ERLELESDLRRAIEQEEFILHYQPQFTGDGRRLTGAEALLRWQHPKRGLIPPAEFVPVLEELGLVAQVGDWLLEQACLQLKAWHRDKVRVPKVSVNLSAR
QFADGQLGERIAGILKDTGIPPACLELELTESILMSDVSQAMQILSGLKRLGLAIAVDDFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHGEQDAQIARA
IIAMAHSLNLMVIAEGVESHEQLEFLRQHGCDEVQGFLFGRPVPAGQFAALFASNAL---
>tr|A0A091BLR8|A0A091BLR8_9GAMM Uncharacterized protein OS=Arenimonas composti TR7-09 = DSM 18010 GN=P873_02285 PE=4 SV=1
--------------------------------------ASTG-TLRD---------------VTE---DRRRQRAVAEAERRYRELFETSPAGLFRAGLD
GRIMEVNPELARILGYDDAEQLKAG---LGDILQAAERDR---LVQGALRRGHVNQSETRVRCRDGSLKWVNASALLIRDEAGNPQHFTGSVLDIDERHA
IQLALQQSETLVENSQVGVFIM-DGDRYTYANQAFARMLGYGEGGLVGVDYRIMAPDSIAQSERRDR--ARRAGEPVAFETTLIHQDGHRVQARVSIGPV
Q-IDGR-EHLTGTVLDVTRQREAEERLRFHATHDPLTGLPNRMLFNQRLAEAMHSARRNDGDYAVLFLDLDGFKWVNDSLGHGAGDRLLVEIARRLEDNL
LRDVLIARYGGDEFTLLPDGPCDDRAVDIARRVLKLFEQPFDIAGQQVFSAASLGIVIGRREYESPDQVLRDADTAMYRAKAAGKSGFVIFDEGMHQQAQ
SRLQLETDFRLAFERGEFELYYQPIVELKGGRLAGAEALVRWRHPVRGLLLPGEFLAVAEETGLIVDLDAWALREACRRLADWRERFPDRLSMNVNVDER
QMVSPEIVEEVFSLLQKHRLPPASLRLEVTETAFRAGRTQAEQRLLALKALGVGLVVDDFGTGYSSLESFAASPFDALKMDQVFIRDVETNPRHRAIVRT
ITAFADELGLALTAEGIETPGQRALLEKVGCQYGQGFLFSRALPAEQFEQLLAEP-----
>tr|A0A091B331|A0A091B331_9GAMM Uncharacterized protein OS=Arenimonas metalli CF5-1 GN=N787_01460 PE=4 SV=1
--------------------------------------ASTG-TLRD---------------VTE---DRRRQRAIAEAERRYRELFESSPAGLFRTSLD
GRIMEVNPVMAGILGYDSPEQLKAR---VPDMGAPGEREG---LVARAVRDGAFSHHETRVRTRGGGEKWVSASVLLIRDEAGNPVHFTGSVLDIDEHHA
MQQALQRSETLVEHSQVGVFIM-RDEVYTYANQALSAMLGLEDGALEGRNYEIMAPESVPQSELRDR--QRREGQAVAFETCLLHRDGRRVHVRVSIGPV
L-LDGV-EHLTGTVLDITRQREAEQRLRFHATHDPLTGLPNRMLFNQRLAEAMLQVSDRRRRYAVLFLDLDGFKWVNDSLGHGAGDRLLCEIARRLEDGL
LEDVLIARYGGDEFTLLPDGDCDDRAVEIARRVLRLFEQPFDIGGQQVFSAASLGIVIGRREYASPDQVLRDADTAMYRAKAAGKSGFVIFDEGMHQEAL
ARLQLETDFRLAFERAEFRLHYQPIIELASGRLVGAEALVRWRHPTRGLLPPAEFLGIAEETGLIVDMDAWALREACRQLGEWRRRYPELLSMNVNVDER
QMVSPEIVEEVFRLIQEHQLPPASLRLEVTETAFRAGRGQAEERLLSLKALGVGLVVDDFGTGYSSLESFAASPFDALKMDQVFIRDIETNRRHRAIVRT
ITGFADELGLALTAEGIETEGQRALLESVGCQFGQGYLFSRALPAEQFEQKLLAS-----
>tr|A0A087MM49|A0A087MM49_9GAMM Uncharacterized protein OS=Arenimonas donghaensis DSM 18148 = HO3-R19 GN=N788_01915 PE=4 SV=1
--------------------------------------ASTG-TLRD---------------VTE---DRARQDAVAEAELRYRELFENSPAGLFRTTID
GQIMEVNPMLARILGYDSVAQLRES---ASDIQSVGERRL---LVEQALRHGSFDHYETRVRCRDGSAKWVSASVRVVHDAQGQPLHFTGSVLDINERQE
ARLALARSETLVEDSQVGVFVM-QGERYTYVNAAFARMLGYREPELVGLSYDIMAPEAIAQSERRDR--DREAGEGVSFGTCLLHRDGHRVHVRVNIGPV
Q-IDGA-QHLTGTVLDISRQREAEDRLRFHATHDPLTGLPNRMMFNQRLAAAMLGA--AGTPYAVLFLDLDGFKWVNDSLGHGAGDRLLVQIARRLEDSL
LADVLIARYGGDEFTLLPDGACDDRARRIAEAVIALFELPFDIGGQQVFSSASIGIVLGGGDYESPDQVLRDADTAMYRAKSAGKSGYVVFDAGMHEQAL
SRLQLETDLRLAFERAEFRVHYQPIVELASGQLVGAEALVRWQHPRRGLLAPAEFLPLAEETGLIMELDAWVLRQACGQLAQWRQAYPALLSINVNVDER
QMVSPGIVDEVLSLLRKHRLPPDCLRLEVTETAFRGGRGQAEQRLMALKALGVGLVVDDFGTGYSSLESFAASPFDALKMDQVFVRDIQTNARHRAIART
INSFAGELDLTLTAEGIETTGQRDALREIGCRFGQGFLFARALPPEQFEQMLSGT-----
>tr|A0A091BJH4|A0A091BJH4_9GAMM Uncharacterized protein OS=Arenimonas oryziterrae DSM 21050 = YC6267 GN=N789_00175 PE=4 SV=1
--------------------------------------ASTG-TLRD---------------VTE---ERRQQDVIAAAEARYRELFQDSPAGLFRTGLD
GTIIEVNPSMARMIGFDSVEQLRAE---LRDMLQPDERQV---LLERAIRDGSFSQYEVEIRTRDNQRRWVSASVRLDRDEAGNPVSFTGSVLDIQARHE
MQQALLRSETLVEQSQVGVFIM-TGSRLVYANHALADMVGRKEAEIVGIDYELVAPEMLRSLHQERE--RFLSTGTMRYESCLLHSNGQRVYVRVSISPV
D-LDGV-RHTTGTILDITRQREAESRLRFHATHDPLTGLPNRALFNRRLAERLAPDERRGNAYAVIFLDLDGFKWVNDSLGHSAGDRLLLEIARRLENHL
VQDVLIARYGGDEFTLLPEGPCDERVVGIARQVLDLFEQPFEISGQQVFSAASLGIVLGRPDYESPDQVLRDADTAMYRAKAAGKSGYVVFDEAMHVQAR
QRLQLETDFRLAFERAEFLLHYQPIVELKTGKLVGAEALVRWQHPKRGLLGPNDFLPVAEETGLIIDLDSWVLREACRQLTHWRKAYPALLVVNVNVDER
QMASKEMVEDVFHLLQTHQLPPSRLRLEVTETVFRSGRKHAEAQLDSLRALGVGLAVDDFGTGYSSLESFAASAFDALKVDQIFVRDLETNPRHRAIVRT
IIGFAKDLGLLLTAEGIETEGQRQMLLELGCEYGQGYLFAQALPPDEFEQRL--------
>tr|Q5P4W8|Q5P4W8_AROAE Azoarcus aromaticum EbN1 complete genome OS=Aromatoleum aromaticum (strain EbN1) GN=ebA2702 PE=4 SV=1
---------------------------------------FIV-LVRD---------------LTE---RVRMEQALIESELRYRELFANSRVVMVIDPVD
GRIVEANAKACEYYGYDPVSLTRMK---IEDINVPLRFEM---V-----QARKPDTFRCCHRLAGGQLRDV--------EVASSPIEIAGRKRDVTERKR
FEERMRQAMVVFKASSQGIMTTDAQGVITSVNPAFCTITGYLAAEVIGRKSMF-KPERHEATFFDAMWTSIVESGSWAGEVWSRRSDGDRYPQWVTITAV
RDTDGRIAEYVTLFSDITERKQQEVAMWRQANFDPLTGLANRSLLQDRLDRALAHA-RRHCKVGLLFLDLDGFKWINDSLGHDVGDELLVDVARRLNSCV
RDEDTVARLGGDEFTVVVHDLADADLGAIADKLVAVLREPFALRGARHHISGSVGITVFPDDGDDVQTLLRNADIAMYKAKQAGKNRAQPYAPHMQADAL
ARVHLEADLRMAVEQRAFELHYQPIVDCASGALVGAEALIRWKHPERGMISPLEFIPVAEECGLIVPIGEWVLREVVRQRRDWLARGHPPLRLTLNVSGV
QFREAGLPELVRTLLAEFGTARSSLVFEITESVLMGGSENVEARMCDIKEQGICFALDDFGTGFSSLSYLKRFPVDIVKIDRSFVRDCPDDRNDATLVEA
IINMAHSLGLRVTAEGVESAEQREFLRALGCDYLQGYLIGKPLAADAFEALMAPL-----
>tr|G2HCJ6|G2HCJ6_9DELT Sensory box protein OS=Desulfovibrio sp. A2 GN=DA2_3488 PE=4 SV=1
--------------------------------------GVIQ-TIRD---------------ITE---RRNQVLELEKSRQRYDMAISATNDGIWEWELA
TNTLYHSPRCLEIMGRAPDEILSMD---VAAILHPEDRLG---VLSEVIEDAERFEHEFRMRHTDGTWRWVLARGAARRAPGGRLARVAGALNAINETRD
LDELFLSIHHHVQAPNFFIAVNEPEDRLDFAYFADERDARYSPVEHISDPTEVIRTGRQLHLHGGDM----EARPVFGPAAWPLRSRGKVIGAMVVQHSA
RDAE-LMVPVAEQVAVAIERKQGEEMLTHLALHDPLTGLPNRALLLDRIDRAIQRRRRNDYRFAVLMLDLDRFKFINDSHGHTTGDNLLVEVARRMRPVV
RAGDTVARLGGDEFALLLEDVDSRRIVQITRRLLAALERPVRMGAKVVRTSASIGMVLRTQGYDTADALLRDADIAMYQAKAQGKGRFRVFNQSMHRHTM
EMMTLEGDLSLALRRKQLYLEYQPVFAVDGPALLGFEALVRWRHPTEGAVPPARFIPMAEETGLILRIGQWVLEQAAATLARWRAELPAALYVSVNLSAR
QASQPNLTGRVARVLSDTGLPPEALKLEITETAIMKDPDGALQRLEALRRLGVGIGIDDFGTGYSSLAYLQRFPVDTLKVDRSFVSGVAGDAENREIVRT
VVTLGRSLGLHVVAEGVETAEQFAIVAELGCHAVQGYHFSRPVDEARAAGIIEAG-----
>tr|K7QWP0|K7QWP0_THEOS PAS domain S-box OS=Thermus oshimai JL-2 GN=Theos_0955 PE=4 SV=1
--------------------------------------------------------------------------------YQLAQVVEQVPESILLTDRQ
GRIFYANPAVEAVTGYRPEELLGATPVFK-SGLHPEFYQS----LWRTLEGGGTFQALFLNRRKDGRL-IAEQILAPLYGPGRKLEGYLATSRLVTEYAL
---------------------SRVQAALLHFNQRFLRLLQEAREGLLGVGGLALFLKGLDGRYSMVAWRGPASQGRLEGEAHRALWGGEALGLLL-ARAQ
ALGPEVEEAFRLLASGLEMVLATEKRTVFFTYHDPQTHLPNRLLLEEEAPALLK----EGSWVLGLMEWQGLLGEFWQAHFSLARALL-----AALRSCL
EFRDRFYQLGPGSFALLLQGGKEALVEGCLERALKGLP---LPPGGAAWLRMALGVALFPEDGASLGELLRHADLALAEAR-KEGGL-AFFNPELARAHR
ERQDTLALLSAALEGEGFRIHAQPIAELESGKPVALELLLRLEV-EGRLVSAGTFIPLAEETGLIVEMDLWLLNRLRELD-----LG---LPLHLNLSPK
TLADPRLLETA------ALLRGRPLEVEVTEYSLAQPGTR--EVLKALKGLGFGLALDDFGQGYASMNALVENPFDALKVDRAFTWGIGQNPKAEAVLRA
ALDLARTLGLQAVAEGVETEEQRRWLLQVGYRLGQGYLLGRPSAV---------------
>tr|W2U8F5|W2U8F5_9DEIN Uncharacterized protein OS=Thermus sp. NMX2.A1 GN=TNMX_00210 PE=4 SV=1
--------------------------------------------------------------------------------HLLSQLVEQVPEGIFTTDLE
GRITYANAALYTQTGYDPSELLGQNPIFK-SGKHEAFYRD----LWDTLRRGQVFRSIFYNRRKDGRL-VVEDILTPIRNLQGQVVAYASTGRDITEWSL
---------------------YRIQQVLIQMLERFLQFLEKVLEAIPGAEAGSLLLRNRDGNFSFVA-REQAPQGRVSGAVLGEFLEGEAIGALYLDAFQ
AFPDEALDPFRFLARWLEMIFSWEVQARYFRYHDPLTGLPNRAFLEEAWREGDE------SLVLVLAD-LDNFGEFNQIHGRKVGDMLLAAAARAWGELL
PKGGELYRLGDNEFLFVLPLEPGVLFYQDLTRALQASA---PSALEKAKLGISVGVVAYPTDGRNLGELLRRADLALREAK-KGRGI-AYFNRELEAAYM
ERVEVLAALEEALREGQLVLFGQPIVDLSTLEAVATEVLVRWPR-EGSFWPAGVFIPLAEETGLIRELDLYVLRRVENLP-----EN---SVWHVNLSPQ
TLRDPRFLEAA------SRLRGKGVRFEITEYALAQ-GVE--EVLQELVEMGFGLVLDDFGQGYASLNTLIQHPFCMVKMDRSFTAGLGKNPKSHAVLRA
SLSLARELGLELVAEGVETQAQRAWLSRLGYRFAQGYLFGTPQPV---------------
>tr|E4U5L7|E4U5L7_OCEP5 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Oceanithermus profundus (strain DSM 14977 / NBRC 100410
--------------------------------------------------------------------------------ELFRAVIEQIPESILITDTE
GRIEFANRTFVAETGYALEEVLGRNPILK-SNRHPSFYRS----LWQALKAGRTFRATFVNRRKTGEL-YPSDLIAPVRARGKEY--YVAFGRDTGEERT
KAELTAVLD----ALPQPVIMVDLAGRLLRFNEQLRRVLDFALEQVPGADAGSLMIREESGDLLFVALHQNKGIFRLSAEAHRRSKEGQEELVLNLDAFR
NFSERDLERMDLLAGALGFFLGWKDQAAYLAYHDALTGLPNRRFFVELGSKLIARA-DRGEPAALLMVDVDRLKTYNDTLGHPAGDVLLKEVARRLKAAL
FDGDVVLRLGGDEFAAVLRGCDAG-AEKATRRILEAMAAPVQVEGRVLQPSITLGVAVAPGDGTSLPELLHKADLALLRAREEGRAL-AFFDAELEAARS
AERELEIELKSALTGGGLDLVVQPILDLRDGSYAHFEVLLRWKE------PPARFIALAERVGLGPALDAYVLDRAEALAR---RLG---KPVFVNLLPS
TLAVGV----P------QRPDPRWVGFEVTEHGVLKPEAH--AHARELAAEGFALALDDFGTGYASLNLLYDFPLHLIKLDRGLILRAQDDAKARALLEG
LVPAMSGMGLEVLAEGVEDERHLAYLASIGVRYAQGYGIARPAPP---------------
>tr|Q0A8D0|Q0A8D0_ALKEH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / M
--------------------------------------------------------------------------------GVWAQRLENSPVSVLITDAE
ARIEYVNPSFTRLTGYAPEEVIGRDPMLG-SGHTPEVYRE----LWETV---RTWQGTVQNRRKDGQLIWERQVISPLRAADGTITHFVAVREDITESKR
AESAIRLRERALESTANGILISRLRNPIVYVN---------PRDEVVGRNGRFLVRDDKDQPGLAVI--------------RNYRKDGTLFWNELFVAP-
REDDGAVHYMVSVINDVTERKRYQAELEQRTHYDALTGLPNRNLLVDRLHQALLYARRSGRHVALLNVDLDRFQIINESLGHAAGDQLLRTVADRLTAAL
RGFDTVARMGGDEFNIVLTELRNRD-ELLAGELQEALAPSISVTGQDVFLSVSVGYTVFPDDGDGPEDLIRRASVAMHEAKRQGGGVIIRYSERSEPRQI
NRLTLESDLQRAIERGELRLHLQPQVDLDTGAMSGAEALLRWEHPRHGLVSPMQFIPLAEEVGLIIPMGRWVLETVATQLAHWGLPV---VPVALNISAR
QFLHAELVEDVRQILEGHGVAPSLLELELTESLMARNPEVAVQILRELKAMGLRLALDDFGTGYSSLAHLKRFPIDTLKIDQSFVRHVNEDGDDAAIINA
TIRMAHSLGLNVVAEGVEREDQLEHLKRQRCDYAQGYFFSRPLSL---------------
>tr|I3Y8L7|I3Y8L7_THIV6 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiocystis violascens (strain ATCC 17096 / DSM 198 / 
--------------------------------------------------------------------------------QEYARELNIREVFWLVNPTM
SEFFYVSPIYEEIWGRSRASLYAE-PSWR-EAVHPDDRRA----VLEAVS--GQVDIDFRLLRPNGSLRWINARGFPIRDERGELIRIAGLAEDVTERKR
AADRIARLNRVVLSGINSAIV-RIHP-----Q---VE----PDGESL-RPRAWRARDPQAPPQARVLCND-ADLEVRSRAALPLRQDGALVGVLMLYARE
GFDAEEQRLLDELAGDISFALQYIERLDYLAYYDPLTGLPNRSLFVDRLGQLLQGAHHDGTQVAVILVDLDHFKRINDTLGRHVGDGVLQAVADRLAATL
EEPSSLARLGADTFAVAIAALPAAD-AILRRCIVDPVERPLTIASQILHLSLHAGIALYPRDGDDAETLFVHAETALGQAQTSGKHH-LYFDSALNAEVA
DKLVLEEELRQALETRQFAVHLQPKVSLRDGAIVSAEALLRWNHPTRGLVSPASFIPLAEDTGLIVPIGEWVLRTVCAQEADWGLRT---VPVGVNLSAV
QFRETRVLELVQDALATVGLAPGYLELELTESLIMQDPAEAVRILNALRALGVRLSMDDFGTGYSSLAQLKRFPFDALKIDRAFIIDIVHNPEDAAIASA
IITMARRLGLTVVAEGVETVEQLCELRAAGCDEMQGYLFSRPVPL---------------
>tr|F9UG67|F9UG67_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_3920 PE=4 SV=1
--------------------------------------------------------------------------------A------GSDAGVWDWDLRT
GKVFY--------------EDICERLAWK-ERLH-EDVQA----LTDAIDRAAAFHHEHRLRRRDGLYLWTLGGKVVERAADGTPLRMIGTTTDISARRA
ASDSLSRLGEIVEKAQTEVYVFDPELCFEQVN---------GMDELLRMTPLDLMPDYD-QPTFPLR---------VVLETRHRRKNGSCYPAEIRLQL-
GV----EPRFVALVTDTTERLRAEEAIKHLAFFDPLTGLPNRRLLMDRLERAIAASRRNHRTGALIFIDLDDFKTLNDTQGHDQGDRLLRQVAKRLASCI
RESDTLARLGGDEFVVMLERLSATHAEVLAKKLLAALRAPCEFEHREYRCSASMGVALFGRHAKSVEELMKQADMAMYRAKAAGRDTLRFFDPQMQVEVS
ARAALATSLRHGLEHGEFLLHYQSQVDVA-GLVTGAEGFLRWQHPQRGLLEPADFIRLAEETATILPLGRWVLEMACVQLAAWETAG---LTLAINISAL
QFHHPDFVEQVLAAVDRHGCNPNRLKLEITENLLLDDRDATIAKMSLLGARGISFALDDFGTGYSSLNDLGQLPLKELKIDLSFVRDLGTNANDAAIART
IIALGETFALDVIAEGVETEAQRDWLAGHGCRAFQGYLFGRPGPS---------------
>tr|Q3SK01|Q3SK01_THIDA Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC and GAF sensor(S) OS=Thiobacillus denitrifica
--------------------------------------------------------------------------------R------G-------VSAST
GTAFFVEGERIENFEYTLVGTPCEQLKTA-THVI-RRVSE----LFPCTARAHAY-VGHRLVDSRGQAIFVLFRPLHETAFITSTLQIFASRVAAEERQS
ADAHIRRQASLLDKAQDAIMVRGLDDAIRYWN---------KADEVTGRST--EMLLYG-DPTAKVI---------WNGEITQLRKDGTALVVEAHWTL-
RDENDQPDAILAINTNVTERKAAEHKVHQLAFYDPLTGLPNRELLGDRLQHAMQV--RHGQVGALLLIDLDNFKTLNDTLGHAMGDLLLQQIAQRLQTCL
RKGDTLARVGGDEFVIVLEGLSAPGATRVGEKILASFARPFQLADYVHHCTASIGITLFNDRPTTLDELRKRADLAMYQAKAHGRNALRFFDPAMQAVVA
ARAELEVDLREALRLGAFELHYQAQVDAR-GCVSGAEALLRWQHPQRGWIAPASFIPLAEETGLILPLGLWVLDVACAQLVAWHMAR---LSLAVNVSAR
QFRQADFAAQVLAAIERSGADPRRLKLELTESLMLDNLDDTILKMSALKAHGIGFSLDDFGTGYSSLAYLKRLPLDEIKIDQSFVRDVLIDANDASIARS
ILALGQSLNLEVVAEGVETDAQHAFLAEHGCQAYQGYLFNRPQPA---------------
>tr|M1NJL9|M1NJL9_DESSD PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Desulfocapsa sulfexigens (strain DSM 10523 / SB164P1)
---------------------------------------------------------------------------------------IARLGYWEWFIPE
NNLFF--------------QGV-VSYVFL-KFVHPDDRQR----VQDAVTTGEPFNIYYRVVTRHRHYLEVRVEGEIEYDTNGLPLRMFGTVQDVT-HRE
RKKQLALAARVFESSIEGITIT--AGIIQSVN---------SREEAVGNKPSILKSDRHDQAFY--------DTGRWEGEIWNRRKNGEIYPEYLIITA-
TDEYDRVTNYVAVFHDLTEIRSYEDQIHFQAYHDALTSLPNRFLMLDRLRVAIGHAQQSSHNVVVLCLDLDNFKHINDSLGHMAGDFLLQQVAERLKACV
EDDTTVARLGGDDFAILLEQCEDKDVVVTAEKILDQFTTSFNLTSYETFITASIGITSFPGDGRDAETLLKNGELAMYRAKIEGKNRYQFFTKGMNSKVI
HRLSLENRLRVALDREEFLVYYQPKVSIGSGEILGMEALIRWQTTDGQVISPLDFVPLAEETGLIVPIGEYVLRKACVDTGKWKNKK---LSVSVNLSAR
QFMEKDLVGTLVAIVHEVGLPVAHLELEITESVVMGNEQTAIKQLLEFKEAGIRLALDDFGTGYSSLQYLRMMPIDTLKIDRSFIKDIPDNKDSSSIATT
IISLAQALNLELVAEGVENRAQLEFLSLQNDMQIQGYLFSPPLPD---------------
>tr|A0A0D2GDP4|A0A0D2GDP4_9DELT Contig_26, whole genome shotgun sequence OS=Desulfarculus sp. SPR GN=X474_15900 PE=4 SV=1
---------------------------------------------------------------------------------------ISQIGSWDWDLET
NELIW--------------SIP-PSVYIL-GATHPEDREL----LRRAIDQGQNFDIGHRIIKADQSMAYVNSINKVVKDASGAVVRLVGTLQDIT-WKQ
ANSQLTLAKKAFDEALEGILVT--NNHIIMVN---------HEEEVLGKTPRILKSKRHNRQFY--------TYGEWRGEIWNRRKSGEAYPQWSTITT-
KDSLGRVDKYVAIFHDLSDIKSKEEELHHQSYHDALTGLPNRKLLVDRLNRALNQAKNDQRHLAVISLDLDEFKTVNNSLGHLAGDSLLQKVASRLTQNT
HHPDLICRLGADEFVLVTPGLKHEDAIFEATHIQELFKSPFIVDDNEIILTASLGIAVCNDFSPDPESLIKNADLALSWAKQDGRGKHRFFTETMDAEAV
KRLKMENDLRRSLANNEILVYFQPKVSCPDGHILGMEALVRWQK-NGKLISPADFVPLAEDVGLIVPIGRYVLTKSCQLTEKWTGQN---LKVAVNVSAR
QFKDDDLIQAVEDALSETGLPISALELEVTESALMQNPEATKKVLEELRKMGATIALDDFGTGYSSLSYLRFFPIDVLKIDKSFVDGAPADQDANMLLRA
ILAMAQGLKLRVVAEGVESADQVRFLHSLGANSIQGYYFSRPLPD---------------
>tr|E6QR57|E6QR57_9ZZZZ Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=mine drainage metagenome GN=CARN7_0471 PE=4 SV=1
--------------------------------------------------------------------------EILRDDGQFTALMDAMPDAVFLKDGE
GRYLVTNESAQQMFQLHNISWQGKT-EMELAALRPAFCAAEHPVDEAAWLAGHLLLSEERFIGKEGQYVTTETRKMPMFDETGQRKKMVVIQRDMTERKQ
SEEKLRLADTVFTHAREGIMITAPDGTIIDVNDAFTLTTGYTRDEALGQNPRILNSKLQGEAFYASMWRDLNENGYWHGEIWNRRKNSEVYAERLTISAL
RDAQGNIQQYVALFSDISALKRHAQQLEHITLYDTLTGLPNRVQLADQLHRDMVEAKRCGQRLAVTYLDLDGFKPVNDHYGHDVGDQLLMTVAARMKQVL
HKNDTLARMGGDEFVAVLGNLDDEASASTLTRLLAAAAQPIYINNTLLQVSASLGVTFYPQEEIEADQLLRQADQAMYQAKLTGKNRYHVFDAVRDREIH
GQHESLIRLRRALTEHEFILHYQPKVNMRTGTVVGAEALIRWQHPERGLLPPAAFLPLIENHPLFIEVGEWVIDTALTQMEIWHAAGLD-IPVSVNVGAR
QLQQVDFVERLHTLLTAHNVKPGKLELEVLETSALEDLIRISQIIEDCRQIGVLFSLDDFGTGYSSLSYLKHLRVALLKIDQSFVRDMLGDPDDLAILDG
VIGLATAFQRKVIAEGVETVEHGELLLQLGCELA--------------------------
>tr|D7DKQ5|D7DKQ5_METV0 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylotenera versatilis (strain 301) GN=M301_2133 PE=4 SV=1
------------------------------------------------------------------------------ENNLLNVAVSGTADAVFVKDKI
GRYLIVNQAAANFAGMPMAEILGKD-DYFLFPESSAKAV----MDQKVMDSRRTQSHEESVVSFGGKSMVFDVTKGPMFDAAGNVIGLFGISRDITERKQ
AEINLQIAAVAFE-SQNSVMITDASLNILRVNKAFTDIFGYTAEEAVGKTAKLLRSGSQDADFYEHIWHEVNTTGSWQGEILNRHKNGQLLSNLLSISVV
KSKDGVVTHYVGSHVDITERKAAADKILHIAFHDLLTQLPNRQLFNDRLKQAIASSARTSQIGALLLIDLDNFKTLNDTLGHDIGDLLLQQVAERLNLNV
REGDTVARLGGDEFVILLEDLSDALDAATGDKILVALNQPYVLGSNHYHTTSSIGVTMFEGHQ-MIADLLKQADISMYQAKKAGRNTLRFFDPKMQEAFN
IRATLEIELRRALESKQFQLYYQVQVDQ-LARPFGAEVLIRWIHPERGMISPLDFIPLAEETGLILPIGEWVLDTACAQLEVWQKETKN-LTLSVNVSAK
QFSQADFVRQVQAKLSRYNVKPQHLKLELTESILLEHVDNIVISMVALESIGVQFSLDDFGTGYSSLQYLKMLPLNQLKIDQSFVRDIVEDSNDRSIVGT
IIAMAKNLGFEVIAEGVETEAQKELLLSKGCQHF--------------------------
>tr|G3IWP2|G3IWP2_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_1939 PE=4 SV=1
--------------------------------------------------------------------------EITRQEARLQKIASQAPGIVFQFDGS
CCVPYANEGLFKIYRVSPEDVREDA-SYVFTVVHPDDLENRLKFEPECWLLGNALPQR---------------------LADG-STLWHGFITDITERKQ
VETELQIAATAFE-SQEGMVITDINNVIIKVNQAFIRLTGYSSEELLNRRMNILKSGRHDAKFYAAMWDSITHTGTWQGEIWNQLKNAEVLPTFVTITAV
KNNEGEVINYVATYTDITERKVIEEKINNLAFYDSLTQLPNRVLLADRMHQTLARCRRNQEIAAVCMLDLDGFKQVNDTLGHAAGDRLLRDVAQRLKECI
RQEDTAARFGGDEFALLLGGFATSECEQTLARIVAAIAAPYQIFGQVAHISASIGVTLFPEDSSDPDLLLRHADQVMYEVKQAGKNGYKLFNSVHEVRNQ
TTQDFLKKIDEALAKGQFELYYQPKVDCHLGKVVGVEASVCWNHPVLGILAPSEFIPVIEHDDLIIALGEWTIQSALLQLNEWRETGFN-LHISVNISAC
QLHSQEFLRRLQELLVGYAELIQRLELEIVETAALKDVIAGGDAIRRCRAMGVRVTLDDFGTGFSSLVRLNHLAVDALKVDLSFVSDMLTDPEDRALVEG
VVGLAASSRLQVIAKGVKYVDQIVMLMELGCDVM--------------------------
>tr|W7PZE6|W7PZE6_9GAMM Uncharacterized protein OS=Halomonas sp. BC04 GN=Q427_11275 PE=4 SV=1
---------------------------------------------------------------------------AETELRKLSHAVEQSADSVIITNRH
REIEYVNKAFEQLRGYQRDDIIGMN--ARIFKSQERNSPTLYQSLRDALEKGDTFRATLLNLDASGETYYEEIAISPLLDPSGEITHYVANSRDVTERIH
AEQELQKLNQAIDQSVSSIVITDANGITEYVNPQFTRTTGYAPEEIKGRRIPLLEPGRLPRSQYRNLLRTLQQGKVWEGEVLSRRKDGESYWELTSISPV
RNRHGIITHFVGIQYDISERKQMEEQINQLAFYDSLTNLPNRALLAQRFDKVASQALQRGKQVALLSLDISRFHLLNDSLGHRVGDKVLQAVGQRLAVCA
RQQDMVTRYAGDEFVVILSDAPDQGIAAVAQRMIDTVSRPLTIECHDLRISMHAGISVLPRDGQDLEALLGNATTAQHLAAREGKNTYRFFTEDLNAAAQ
QRLALEQDLRRALEDNALELHYQPKVDLATGEVVGMEALARWHHPSEGHISPMTFIPIAEDTGLIQPLGEWALRQACLQGQAWRHQGLGRLNMAVNLSTR
QLQQVDLAASVGRILADTGFPPELLELELTESAVMERPEETIRVLNELKALGVQLAVDDFGTGYSSLAYLRRFPFDTLKIDRSFITNITTSPDEASIAQT
IIAMGRGLRLQVVAEGVETQAQAATLRRHHCDQLQGYLFSRPLPARELETLLRE------
>tr|W7QLL2|W7QLL2_9GAMM Uncharacterized protein OS=Halomonas sp. BC04 GN=Q427_09700 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----MIDAAID------------------------------------RIKAGQRVHAEARTRDAQGDVHWVEINA-----DLGTERVIYVVARDITQRKR
GEQRLHILERSIESSVNGVIIAEANHPIIYVNSAFERITGYTRQEAMGRNCRFLQGPDTDAEARGVIRRGIATKCYTHATLCNYRKDGTRFWNDLHISPV
LDENGKVSHFIGVQNDISTQRAYESRLAHNATHDSLTGLPNRSVLEERLQLCYQRTRLPIGSVAVLYIDLDDFKSINDSLGHDLGDQILVEVASRLVQQV
RASDTVARCSGDEFAILLPDPG--SVILIVERLLASVARPYRIEQSELHLTASIGIALDPDSVARPSHLVQQAALAMYQAKRQGRNTYHWYTEGLNKKAS
ERVMLRNALQHAIDEQQFELHYQPQIQGASGRIIGFEALIRWHHPERGYILPAEFIGLAEDTGQIIPISEWVLRTACRDNVRLNALGIGEYLMAVNVSPM
QFQRANFVPGVMETLKNAGLAAHLLELELTENILMESTTKAIEILQSLRRHGISIALDDFGTGFSSLSYLKSLPIDKIKIDRSFIREVISDHRDAAIVQG
IISMASQLQLKVLAEGVETQAHYAFLSKKMCDIYQGFYFARPMPIEDLITFLHD------
>tr|W6M5W3|W6M5W3_9GAMM Putative Diguanylate cyclase OS=Candidatus Competibacter denitrificans Run_A_D11 GN=BN873_470033 PE=4 SV=1
---------------------------------------------------------------------------LEEEIRRLRQNLQQLPVGIFMADLQ
GQCRYVNERWCQMTGLAAEQTVGLP--WTHALH-PDDRDQVEKIWRQALDKGSEFVVDHRFKTPTGRDVWMDTRAVPLRDRSGQIVYYLGANTDIAELKR
TEETLRASEARFRSYFELLVGIALTGRWWEVNNRLCEMLGYRRSQLLQLTWAELTYPEDLAAQFERVSRRID---GYSVDKRFMRQDGSLLYASVSTRCI
RRSNGMVDYYVALIQDISERKQAEEHIQHLAHYDALTDLPNRTLLGDRLQQVLLRAARDHTQVGILLVDLDHFKRINDTLDHTVGDQLLREVGHRLQSCV
RECDTISRQGGDEFAVVLPDLINDEAPRIAERILGAMTEPYRFSDHDLHITCSIGISLYPRDGRSAEILLKNADNALYRAKDLGRNNYQFYQSGATMVAR
ERLTLENSLRYAVDRQQLELYYQPKWDFHANAITGAEALIRWNHPQLGLLPPARFIPIAEDSGLVLALGEWVLRAAVQEIGQLHQNGASGLRVAVNVSAR
QFHQGNLTTLVQGLLTESGFDPGSLELELTEGILMHHTEDNITALKSFKAMGVRLAIDDFGTGYSSLGYLQRFPVDVLKIDRSFVTELPSNESNVAIVDA
IVTLAHGLGLLVVAEGVETVEHVEFLRAHGCDEGQGYYFGRPVPLLEFQSLLMR------
>tr|E4Q760|E4Q760_CALOW Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Caldicellulosiruptor owensensis (strain ATCC 700167 / DSM 13100
----------------------------------------------------------VLIMIKINKRL---EHGKRAYESYAQLLADNANAIVLTLNLK
GEIIYFNKFAEQLTGYTSEEVIGKK--W-TDIFIPSHRREIENLFSKIAEEKVLNDHENEIITKNGDIRWILWNNALIESPYLNEPLIISTGLDVTQIKK
TQQLLEESYEFVDNVSDLVFELDINQKKIELYGKLKDSFDVETICSTKSSLVYLHEDDRGKVFRKFQDAIFLGDEYVELDFRVKDKCGRWRWLSSRAHIN
YDEQKNPEKIVAVCVDWTAKKEYENKIEYLAYYDTLTGLPNRKLFEETLEDWLKKTKAEKSTGAVVLIDIDNFKDINDIYGHEAGDEYLKALGEKVSEYL
KVKTFFARVGGDEFAIIFHGLVKEQVIEFCAQLLKIFESEIYIEDRHLFTSASMGISFYPDDGKNVKEIFRNVDMALSSAKDNGKNDFQIFMPFMLMKNL
KKIEIEKNLKKAIEEDQFELYYQPVINLKDMEIHSVEALLRWNLPGKGMVSPLEFIPVAEESGLIVKIGEMVIEKAFSDIKNWERKGIDYINMAINLSVR
QFKTKFFVDVVKKLIERYSVDPQKISFEITETGAVENFDVSLKILNFLCQMGIKFMIDDFGTGYSSLIYLRKLPIGGVKIDKSFISEIESSKESRAIVEG
IVLLAHKIDLKVVAEGVETKKELEILKEIGCDFAQGYLFSKPLPKTEVEKLLIAK-----
>tr|E4QAI1|E4QAI1_CALH1 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Caldicellulosiruptor hydrothermalis (strain DSM 18901 / VKM B-2
----------------------------------------------------------IFVMTRINRRL---EHGKQAYEKYAQLLAENANAIVLTLNLN
GEIIYFNKFAEQLTGYKSEEVVGKK--W-TDIFIPSHRREIENLFKRIAEEKVLNDHENEIITKNGDIRWILWNNTLIESPYLNEPLIISTGLDITQIKK
TQQLLEESYELVENVSDCIWEIDFQEKKIEFYGRLKDLFDIDAIKSKNDFSAFFHEDDRSTVFKKLQDAILLHEENLEFEARIRDKNGNWRWISSHVQIL
YNEEDKPEKIIAVNIDWTAKKEYEHKIEYIAYYDALTSLPNRKLFEERLESLIKKAEDEKTQGAVVLIDIDNFKDINDLYGHEAGDEYLKAVGEKVLEYL
ELKTFFARVGGDEFAVILHGLAKEEVIEVCTQLLSIFESEIYIQEGHIFASASMGISFYPDDGRSVKEIFRNVDMALSSAKENGKNDFQIFMPFMLMKNL
KKIEIEKSLKKAIEADQFELYYQPVINLKDMEIHSVEALLRWVLPEKGIISPLEFIPVAEESGLIVKIGEMVIEKAFSDLKNWERKGISYLHMAINLSAR
QFKTKFFENMVQKLIEQYGVDPKKISFEITETGAVENFDVSLKILSFLCQLGIRFLIDDFGTGYSSLIYLKKLPIGGVKIDRSFISEIEFSKENRAIVEG
IILMAHKLDLKVVAEGVETKRELEILKEIGCDFAQGYLFSKPLPKTQVEKLLLAR-----
>tr|G2PZ81|G2PZ81_9FIRM Diguanylate cyclase/phosphodiesterase with PAS/PAC and periplasmic sensors OS=Caldicellulosiruptor lactoaceticus 6A GN=Calla_24
----------------------------------------------------------IFVMTRINRRL---EHGKQAYEKYAQLLAENANAIVLTLNLN
GEIIYFNKFAQELTGYKSEEVVGKK--W-VDIFIPPHRREIENLFKRIAEEKILNNHENEIVTKDGDIKWILWNNTLIESPYLNEPMIISTGLDITQIKT
TQQLLQQSYKLIENGSDCIWEIDFKEKNIEFYGRLKDLFDIKAVKSKNDFSAFFHPDDRSTVFKKLQDAILLHEENLEFEARIRDKNGNWHWMSAHVQIF
YNEEGKPEKIIAVNIDWTAKKEYEQKIEYIAYYDALTSLPNRKLFEEVLEDFIKKAEEEKAQGAVILIDIDNFKDINDLYGHEAGDEYLKAVCQKVLEYL
KLNTFFARVGGDEFAVVLHGLAKEEVIEVCTHLLNIFESEIYIEERDLFASASMGISFYPDDGRSVKEIFRNVDMALSSAKENGKNDFQIFLPFMLTKNL
KKIEIEKGLKKAIETDQFELYYQPVINLKDMEIHSVEALLRWISPEKGMISPLEFIPVAEESGLIVKIGEMVIEKAFSDLKEWEKKGIDYLHMAINLSAR
QFKTKFFENMVQKLIERYSIDPKKISFEITETGAVENFDVSLKILSFLCQMGIKFLIDDFGTGYSSLIYLKRLPIGGVKIDRSFISELEVSKENKAIVEG
IILMAHKIDLKVVAEGVETKRQLEILKEVGCDLAQGYLFSKPLPKAEVEKLLIAR-----
>tr|A4XFJ6|A4XFJ6_CALS8 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Caldicellulosiruptor saccharolyticus (strain ATCC 43494
----------------------------------------------------------IFVMRGINKKL---QQGKEAYEKYAELLASNANVIVLTLNLK
GEIIFFNRFAEEVTGYKKEEVVGKR--W-VDLFVPEFRREAEKLFSEIAEKKVLNNYESEIITKNGDTCWIIWNNVVVENSYLNEPLIISTGLDITPIKK
NQRLLEESYEIVENISDCIWEFDVAEKRIEFYGNLKDYFETDKINPKIDYYALYHPDDIKAVMEKIQRAFELRDEKIEYEARIKDKNGNYKWVSVHIKVF
YDNRGKPEKLIGINIDYSAKKEYEDRIKYLAYYDDLTNLPNRKLFENKLSELIKKAAQTGKIGAVILIDIDNFKDINDLYGHEVGDECLRTISQKIAEYL
KVQNYFSRVGGDEFAIILNGLEKDFVIEVCTEIQKIFENEIFLEERGLYTTISMGISFYPDDGRDTKEILRNVDMALSLAKENGKNDFQIFMPFLLLKNL
NKIEIEKNLRKAIENDEFVLYYQPVVNLENMEIHSVEALIRWFLPHKGMVSPLEFIPVAEESGLIVRIGEMVIEKALKDLKDWERKGINDIHIAINLSAR
QFKTKYFENTVAKLLEKYSVDPVKVSFEITETGAVENFDVSLKILGFLCQMGIKFLIDDFGTGYSSLIYLRKLPISGVKIDKSFISELMFSKESRAIVEG
IILMAHKLGLKVVAEGIENNKQLEILKEIGCDFGQGYLFSKPVPKEEVEKFLLQK-----
>tr|X4ZEM4|X4ZEM4_9BACL PAS/PAC sensor-domain-containing diguanylate cyclase/phosphodiesterase OS=Paenibacillus sabinae T27 GN=PSAB_01460 PE=4 SV=1
----------------------------------------------------------RMYIIHLRRII---RAE----QQFFEDVIEHTGILVWAVQKD
KTVLRLNKYGERVTGLREQEIVGQS--L-DDVELKVAGGTLKELLYRAIGYDFAGHEEFQIPSGAAEGRYFTFRTMLIKGLGGASDAFVLIGIDIDELKR
NERKLESSFWAVEASGALLWEYNYEKECHWVSDRWYEVMGYQPGELDLSVDTLIHPDDRERSRKAREEHLAGLAPVYESEYRMRTKDGRYYWFEVRGKAS
IDQRREVPMFLGSLIDISNRKENQKKMHHLAYYDSLSHLPNRLCLLETMEEYFQ---IPGGSAALLFVDTDNFKYINDTMGHKFGDILIRQVSEKLQSVV
REGSMLARLGGDEFVVFIKDVEEKEVIELAERLLKEFENPFQIGESSVYISVSIGISFYPADGNTTEEILKSADVAMYRAKEAGKGVYALYDKSLHTEFK
ERMTIEKHLRSALDNEEFELFFQPQVDLLTGDISGFEALIRWNSPDLGFVSPLSFIRIAEDSRLIIPLGEWVLRKACHFMAEMSRKQYNHFRIAVNISVI
QLLQDNFIPTVLGILSESGIAPKCLELEITESVFMESFERIVDKLEYLQSQGIRIALDDFGTGYSSLSYLQQLPISTLKIDKAFIDPLSDNSYSQSFIKT
MVSLGHEMGLEVVAEGVEDRSQLAFLKMTGCDKVQGYLISKPLPERNTRELLEKW-----
>tr|W4BU93|W4BU93_9BACL PAS/PAC sensor-domain-containing diguanylate cyclase/phosphodiesterase OS=Paenibacillus sp. FSL H8-237 GN=C171_27111 PE=4 SV=1
----------------------------------------------------------KMYINHLRRAV---YSE----QQFFEDVIEHSGMVVWAVQAD
KKVVRFNNYAERMTGLCENEVVGKN--I-ADMEGLTGSTAIRNLLERAVQLDYVDNIEHKLPDNSPAARYFSFRTTLLKGLDQAADIFVLVGVDIDERKQ
NELRLQQSYEATEGSGAYMWELDWETGLYNLSDRWYKLMGYTEDEINSFENGIIHPDDQPSSQKARHDHLAGLTPIYETEYRMRTKDNQFVWFEVSGKAI
VDPKDEVVLFIGSLIDISKRKENQKHMHRLAYVDELSNLPNRVCLLESMEKYLQ---CSGGKAALLFVDTDNFKYINDTLGHKSGDVLIQKASKRLQSLV
REGDMLSRLGGDEFVIFIKDIEDEDVLDLAERIMRAFRQSFLIGESYLYVSVSIGISFYPEDGETTEQILKNADVAMYRAKEDGKGTYVVYDKSMHTAFN
ERMNIEKHLRSAMNNNEFELYYQPQVDIQSGLISGFEALIRWNSPTLGFVSPLSFIKIAEDSRLIIYIGEWVLRESCIFMKGIQDRMGIPYKISVNISII
QLLQDDFVEMVQESLAESGLKPSCLELEITESIFMESFESIVNKLQFLKSQGIRIALDDFGTGYSSLSYLQQLPISTLKMDKTFIDSLSEKAYSQSFVQT
IIQLGHNMGLEVVAEGVEEISQLDFLRKSGCDKVQGYLVSRPVPKQEVVELLEPQ-----
>tr|W4BXX4|W4BXX4_9BACL Diguanylate cyclase/phosphodiesterase with pas/pac sensor(S) OS=Paenibacillus sp. FSL R7-269 GN=C162_16670 PE=4 SV=1
----------------------------------------------------------RMYIRRLRRTI---HSE----QEFFKDVIENTGVIVWAVHGD
KRSVRFNKYAELMTGLKEKEVLGVS--I-DELTGLEAGAALRDLLAKAAAQDYVTNVELRLPDHSPGAHYFSVRTALIKGMDQAENIFVLVGIDIDERKQ
NELKLQLSYEASEGSGAYMWELDWDSGFYKLSDRWYEVMGYTEVEINSFEGGIIHPDDQESARKARQEHLTGLTPIYETEYRMRTGQGEYIWFEVRGKAI
VDPKDQIVLFLGSLIDISKRKENQKNMHRLAYMDSLSNLPNRLSLLETMESYFR---RTGGSAALLFVDMDNFKYINDTLGHKSGDILIRKASERLQSVV
RRADMLSRLGGDEFVIFLKDVESVDVLNLAEDIMRAFRKSFLIGESNLYVSSSIGISFYPEDGETTEEILKNADVAMYRAKEEGKSTYVVYDKSMHTPFN
DRMNIEKHLRSAMNNNEFELHYQPQVQMETGLISGFEALIRWNSPVLGFVSPLTFIKIAEDSRLIIYIGEWVLREACKFMNSIQQRTGIPYKISVNISII
QLLQDDFVEIVLDGLAESGLAASSLELEITESIFMESFGSTVSKLEFLKSRGIRIALDDFGTGYSSLSYLQQLPISTLKMDKIFIDSLADKAFSESFVQT
IIILGHKMGLDVVAEGVEDASQWAFLQEAHCDKVQGYLISRPVPQRQVMELLVPQ-----
>tr|R9L703|R9L703_9BACL Diguanylate cyclase (GGDEF) domain-containing protein OS=Paenibacillus barengoltzii G22 GN=C812_03364 PE=4 SV=1
----------------------------------------------------------RTYIKRLRRTI---HGE----REFSREVLDHSNLFIWAVHGD
GTTVRFNRYAEMITGIREGEAIGRP--Y-TEHALLQHACRLIPLLDQALAYRFVDHCEIHLFCAQGKDKAFLFRTTVIPGLKGDPDVFIMTGVDIEERKQ
FENKLHCSYQVTEASNGGIWEWDLDRNHRYYSPRWFELLGYEQEDLITSE-MVVHPEDNAKIHEEFASLQAGVKEVFECEYRLRCKNGEYRWFLGRGKAL
FDDQGRAYRMVGSNIDIHQLKLYQQRMRHLAYYDTLSDLPNRLYLLEKMDELVS---QEDAKAALFFVDTDNFKFINDTLGHKFGDRLLIQASARLTSLI
GEVGMLFRLGGDEFVILMNDAG-EEATGLAQKLIQGFKEPFRIDDSDLYVSISIGISFYPEDGRSPEEILKNADVAMYAAKEAGKGQYAVFAPAFLKAFN
ERVVLEKNLRHALDRGEFIIHYQPQISVRDGQICGFEALIRWNSPELGFVSPLSFIKIAEDSRLIVPIGEWVLREACAFAKRLEDDGFGTYKIAVNISVV
QLLEEDFVGKVLQILQETGLNPEYLELEITESMIMETLESLVPKLNELKANGIQIALDDFGTGYSSLGSLKQMPITTLKVDRSFIEHLPEQDDSRSLAKA
IVLIGRKMGLQVIAEGVETKQQMEHVRRAKCDVIQGYYISKPLPEAELRDLLRSF-----
>tr|B9R6G6|B9R6G6_LABAD Putative uncharacterized protein OS=Labrenzia alexandrii (strain DSM 17067 / NCIMB 14079 / DFL-11) GN=SADFL11_2225 PE=4 SV=1
----------------------------------------------------------SLQLINLNEEL---SEERKRSQRDLETFFNQSQSLNLIVDFK
GRILRLNDSWEDFLGYELKEVAERP--F-IEFVHPEDRA-TEAAFTALLVGDGIDGFENRYVCACGAAKYLRWSARS-----VDRQLIYAVAQNITEQKK
AENALKLAAN-----DEGIIITDINGAIVDINEAFTDITGYERDEILGNNPSS---GKHDADFYQTMWSKLRKDGVWQGEIWNKRKDGDVFAERLTISAI
EDESGNTTNYIGLFVDITKMKAHERQLEHLARYDRLTGLPNRVLLADNMQQAMARARRHGHTLAIAFIDLDGFKAVNDTYGHAAGDELLVSVAHRLTKVL
RTEDTLARIGGDEFVAIITDLPDKSCVSTLNRILDAASKEFKLGAATASVSASIGVTFYPQTEEIGDQLERQADQAMYEAKISGRNQYKFFDPEQDRRLT
EYYAQVADAKKALKTDAFRLHYQPKIRLATKEVIGYEALIRWQHPEKGLLMPGAFLPPIEHPDVAIELGNWVLDNALEQIERWNEVGLDT-TVSVNVSAL
QLTSSDFEETLNKHLQKHAAEPCQLEIEILETDALSDIERVSKIIRNCRLSSVRFALDDFGTGYSSLAYLKQLPIDTLKIDQGFVHDSLNNAQDQELLKL
IISLGRVYNIDVLAEGVETPAHAELLHTYGCRYAQGYAFARPMPADDVLDWHSNW-----
>tr|B2UEU8|B2UEU8_RALPJ Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Ralstonia pickettii (strain 12J) GN=Rpic_0283 PE=4 SV=1
----------------------------------------------------------------------QTGEALAQSEAEYRSLFETNPYPMWVSESS
GKFLAVNDSAIKHYGFSRETFLAMR---ANDLDAPEQHS---QKSEPTESGGPTVTSGVKHRDARGDTLEVELAYFPLRF-QGR-NATLALISDVTYRSA
LTHTIREQKEFFSLLGSTVEALDQNGCCTFANAACERLLGYSAQELAGKPMHAHHTHEDGSLAACQIQNSIASGAHVHVDNEFWRSDGTSLPVEYWAYPI
VRD-GQVAGSIVTFIETSERRRQQDELRRRATFDDLTGLLNRPSFVTALETRLQQADASERHPVVAILDLDGFKEINDSLGHATGDQLLRGVAERLTDQL
GPHADVGRLGGDEFAFVVDESYGPPIATRIEAVMESIRRPFSIAGLDLAINGSVGAARYPGAGLDVDTLLRSADVAMYVAKREGH-GFTFTDRVDAGTP-
-RPFLLSELRRALQEDEFILHFQPTIPLQGLPHFGFEALIRWNHPRLGIVGPGEFMPMVEVSDLIHPLTEWVIASAVSRFKTIIES-WPNAFVAVNVSMR
NLINQKFTSSVQYLVEQNRFPVNCLKIEVTESAVMADPDRTLRALNELHGLGVRIAVDDFGTGYSSLAYLQKLPVDDLKIDRSFVSGLSGSQPSKAIVHS
IISLAHSLGLSVTAEGIESEADMRILRAAGCDFGQGYYIGHPMPFDAVHDWLKS------
>tr|W8WUK6|W8WUK6_CASDE Uncharacterized protein OS=Castellaniella defragrans 65Phen GN=BN940_03801 PE=4 SV=1
------------------------------------------------------------------------QRSLAQSEQSYRLLFEGSPNPMMVLSLS
GRFLAVNDEAMRRYGYGRDHFLRLG---LDDLRIEVLEH-------------PDTAFSYEHRRRDGQPLFVEVRSLSLMF-TGQ-LAHVLVIRDLTERET
LSRGLKERERLISQLDVTAEALDASGCCIFANQACSHLLGYDHDQLVGQHFHSHDRHEDGSLEECRMHLALREGKGIHVDDELWRRDGTCFPAEYWSYPI
LQD-GRLEFCLVTFLDISERRAQQRALAYQATHDPLTGLLNRGDILRRLQARSEQSPE--APWTLVMSNLDGFKEVNEALGHDAGDRLLQAVAQRLQGLL
GPACMLARLGSDEFAFLLDTGDEHLAQEQVHVLLAALRDPFALNDLQIRISCSFGLAVHPGHARDPDELVRCADTAMRRAKRDGL-GIAVFNPQDRASVH
DHLLLRGELRTALAQGQFLLHLQPKVFLNDGSPMGFEALTRWMHPERGLIPPGRFIPIIEVSDLIHPFTLWVVDQAVACCSRLQAV-HPGVGMAVNVSAR
NLLDGHFPSQIRDALLRHGLDPALLELEVTESAIMADPTRALDTLHALHALGVRLSIDDFGTGYSSFAYLNRLPVDALKIDQSFVAGMAADADMRAIVRS
IIEMSHTLGLMVIAEGIETQETLDLLWNMGCDVGQGYFIGHPAPESSAEAWLRG------
>tr|A0A0D5AV64|A0A0D5AV64_9RALS Diguanylate cyclase OS=Ralstonia mannitolilytica GN=TK49_20140 PE=4 SV=1
----------------------------------------------------------------------AIEQELRASEANLRVAEQIAQLGSWRWDVR
SGMTGTPPGAPPTFAQQAQFFTADS---YHRLREAASRA---VT------EG-PYSLELEI-RRDGERRWVLSRG-NIER-NEQGVALFGTMQDITERRE
SDEQLRLLRRVVESVPSGITVQQPDLPVVYVNPGFERMTGYRAEV-LGRNCRFLHSSEPGQLNEVR--AALRDASEIRVLLRNFRKDGHAFLNNFLLSPV
RDTQGVVTHYVGIQDDVTEQEMTRARLAQHATIDPLTGLPNRTLLADRVQQAVEMAARQRSRFYVALVNIDRFKVVNDSLGHLLGDEVLRRVAERLRDAA
DSVDTVARFGGDVFALVISHAGSRG----VDFGFDLFAEPIRAEGHEVFVTASIGVAEYPAHGPDADTLIRHAEMAMYAAKQNGRNRLEFFAPEMDIGVS
YRLNLEHQIRAALEHGQFRLLYQPQVDTRTGRVCGLEALIRWVHPTRGLLPPAAFIPVAEESGLIVEIGNWVLSEAARQRAEWHARGLDGLTVAVNVSPL
QFKRGTVLPTLLRLQREYGLSSGFLELEVTESMLMEGTERTIEDLTAIRQLGVRIAIDDFGTGYSSLAYLKRLPIDLIKIDRAFVKDIDRDSNDAAICTT
VVVLAHNLGVKVCAEGVEDPAQSAFLASHQCDVLQGYYFSEPLLPDAVTALLER------
>tr|Q5NYX4|Q5NYX4_AROAE Azoarcus aromaticum EbN1 complete genome OS=Aromatoleum aromaticum (strain EbN1) GN=ebA6328 PE=4 SV=1
------------------------------------------------------------------------------QTCIVRDIANDSRFPAWRDEAR
RGYISVPLVADQA--FGVLTVLTGE---AGAFDAEETRL---LE-------NRELAFGLVLRRR------------------------------TAQEKA
-EAEVQLRNRAIEAS--NGLVYAPPAGIVSANPALLRLL----------------------MDEEQLIAMDLPTLARQGFDEGWEQLDVCWLDTSVTLVG
DDV-AGIDHAVIEFRDVTERHRYQEQLAYQANHDSLTGLPNRNLLGDRLQQSLALAACNSSLRFVLWVDIDRFQVVHDSFGNEIANATLVVLSQRLAGAA
TGCSIVARVASDEFVLITEELPSQQVVSLATRLLDALRAPISAGGEELWLTGSIGVAAMGGADLDVDTLLRNANVALFRAKEMGRDTFCFYETGLNVRTA
PRLRLELALRRAIEQDELFLAYQPKVDLLTGEVVGSEALCRWRHPELGLVSPGEFIPIAEESGLILPIGRWVLETACAQARRWIDDGIDYRRVAVNVSPL
QFFRDDLVADVAALLSRYRLEPASLMLEITESAIMGNPARAIVMMQQLKAIGVKLAIDDFGTGYSSLSALKRFPIDYLKIDRAFVTDITTNASDAAIAVS
IISLAHSLNLRVIAEGVETEGQVLYLRGRGCDEMQGYHFSPPVAPEALATLIRD------
>tr|A0A0C1YI50|A0A0C1YI50_9BURK Uncharacterized protein OS=Herbaspirillum sp. TSA66 GN=TSA66_04380 PE=4 SV=1
-----------------------------------------------------------------------------ARYRELAGILDQVPAGILMASGS
GKLLFMNRAGAALLGNPIAVDHSND-EAYRAIHTPYTPDEYP--MARALQGETVYSKEMLYVRSDGSRGCLRVAASPVKDGQGRTIRAIEMLSDVSLEWQ
AQKRLADAETATEIAGLGFWEWDIRSNDMYFSPQWKRHLGYRDEELPNRYEEWESRMHPADRARAGLEAELKRGGDYHVQFRLQHRDGSYRWIEAKAQIQ
RDEQGQPQRMVGTHIDISDHKEREEQVRLIAQHDRLTGLPNRALTFELAEQSLSAAHRNGKMCAMLFVDLDGFKPINDIYGHHIGDEVLKEVALRLKGAF
RAQDTVGRIGGDEFLIALTQLDAQGAVHAAAHALHQLSLPYHIGDLVLHSSPSIGISLYPRDGADIETLVRHADAAMYDVKQHGKAGYRFYSNN-GTMQP
DTMQLQHRLHESMAHQSLQLYFQPMVNLSTQRVIAAEALLRWPTPQGVTMSPDMFVAIAEQSGFLDELSNWVLQTACAQHDEWKQQGLPAIDIGINLSPS
QLREAGLPDAILQQIARCPIDPAHLWIEISDRTLNGGTPYTLAALDRLKALGVRITLDDFGVGHSPLERLSRLPFDRVKIDHTLIMALPHDKASAAVTEA
AISFGNSLGIEVVAEGLESQQVLQFLQEHHCHCAQGFYLARPMPGAQFAEWYRHAG----
>tr|N6WPD3|N6WPD3_9ALTE Uncharacterized protein OS=Marinobacter nanhaiticus D15-8W GN=J057_16055 PE=4 SV=1
-----------------------------------------------------------------------------IEQRQLEAAIAHAPVGVVVADAR
GVVLKMNDAHQRLWGIEPPVNLNFR-AWERPGRRPLELDEWP--LVRALKGQTVTNEETFVPPERKI---VQASSAAVRDKQGNIVGAVISAVDVTAQHK
AEAIERDTSAVMDASRIGDWDLDLVNDTAQRSLIHDQCFGYPEGAPHWGRETFLEHVHPGDRAWEEFAKAVAEGKDLDVECRVVWPDGSIHWIHAQ-GRF
YASQGRLTRMTGIVQEVTERKLASQQILHASLHDPLTDLPNRAKLFEYSSHLLAHNHRSGQQAATFFLDLDRFKQINDSHGHAVGDALLQEVALRLRQCV
RAEDFLVRLGGDEFLVLYPEIADETAAEMARNFIERVSAPYRIQGKSLTLGISVGISLFPKDGTDIDTLISHADLAMYQAKQSGRGQYSFYSRALAADAR
LKHIIEHKLSETIRDKGFHLAYQPIFDLTSGEIVSVEALLRWSDTNIG---PEQFVPVAEATGMIGAVGGWLLDEVADQYAAWQNMNLPPLPIAINISVV
ELRDHEFVDRFFESLAKAGLPPDAIQVELTETTAMDDIEFKIGQLSKLRSRGVTIALDDFGTGHSSLTYLARLPVNKVKIDKSFITGLGSNSVSQTITGA
IVALSRNLGLDVVAEGVETQSTLEHARALGCQQGQGFHLARPMTCDDFDAWYRKYL----
>tr|F1Z3A2|F1Z3A2_9SPHN PAS:GGDEF domain-containing protein OS=Novosphingobium nitrogenifigens DSM 19370 GN=Y88_3415 PE=4 SV=1
-----------------------------------------------------------------------------LADDRVRLLLDTIPVALSLEDGN
GRRVSLNRESEALWGEAGPAADAIP-LRQPCDCCGEREVIWD--DERQ------ACR---------T---LRTLRRAIFDEHGQLRHMLNASVDITESKR
LELELRDSEKIALTTMDGAY-LEFN-----EAFC--RICGYSPDEIRKLDYWALT-----PRKYEQLRSLLEFGHIRKDGCCVPLRLTGV---------L
LQGSDGKSYIWSIIEDVTEQRKSQEAIWRHANFDMMTGLPNRRMFYERLERDILSSAVEERRLAVIFLDFDNFKEINDAFGHDKGDEVLREAARRLKSHL
RESDVIGRLSGDEFTLILRSFRDQEIDNVVQRLLATLSEPYRFGADILHASASVGIAVYPDDGAAADELIRHADQAMYEAKAQGQGRFSHFHRELQEEAS
HRSRMAMELRHALVEKQFRLYYQPIVALDSGEVLKAEALLRWEHPRLGLIGGGDFIPVAEQAGSIHAIGQWVFEEAANQVARWDRAGCPPIQLGINRSPV
EFRRPNALDAWTTQLAQLGLCGSRFVVEITEGLLVEQTPVVRGQLEQLGRIGSGLALDDFGTGYSSLSYLRKFDVDFLKIDRSFVQGLAPGSEDLALCEA
MIVMAEKLGIKVIAEGIETEQQRDLLAAAGCHFGQGYWFGRPMPAEAFTRRLLQGK----
>tr|A0A091BBU8|A0A091BBU8_9GAMM Uncharacterized protein OS=Arenimonas composti TR7-09 = DSM 18010 GN=P873_01205 PE=4 SV=1
------------------------------------------------------------------------------AELNYQALLNAIDKGVIFQGAG
GEVLSGNAAALRILGIEA-ADGRWQ-DWV---DYPIAFRDMP--PLRALRTGEIV--TLLYHHLRQQLTWISATSVPQRPGEERPHQVVSLFSDVTELKR
DSAMFVR---AQTLARIGGWEWDGGRGRLYLTGESLRILGRHEDPPAHLDD-VLAHVEAGQRPQDAVLTLLRHGGGFDLEVPLRRRDGERRWVRF-IGQS
EGRAPMSTRITGTLQDITQHRQIEEALRSRARTDPLTGLFNRDGILAELERRLET--GG-DGPTVLYIDLDRFKLVNDLLGHAAGDHLLVSVAQRLEACV
PG-GQLARFGGDEFLAVVDVAE-GAAEALASRITGAFNAPFRCAGEEFTITTSVGIARHPQDGRSVQQLVNNADAAMYDAKRRGRNTWQRFNPELARRQS
DRVQVEGQLRRALDNGEFRLVYQPLVDLVDGRVHRAEALLRWHSPVLGEMSPDAFIGHAETTGDIVRIGAWVVHSACRQLAAWRREGLALPRVAVNVSWR
QFLTEDLPQVIAAALAEHDLPGEGLELEFTERVLIEDAPDTHDSFERLRALGVRLTIDDFGEGYSALNYLRRLPIHGLKLAQGFLQGVPEAPSDVAICQA
VAGLGHGLGLEVVAEGIETAAQREFLLGIGIRCGQGFLYAPGLEVDDFAAYLRRVG----
>tr|A0A091BNY4|A0A091BNY4_9GAMM Uncharacterized protein OS=Arenimonas metalli CF5-1 GN=N787_11570 PE=4 SV=1
------------------------------------------------------------------------------AELNYHALLSAIDKGVLFQGFD
GRPLSANPAAYRILGIDD-LDARFD-DWI---DYPISFRDLP--PLRSLATGEIV--TLLYHHRRKQLTWISATSVPQHPGASKPHQVISLFSDVTELKR
DSSLFLR---AQALARIGGWEWDGGRRRLYLTDEALRIIGRRDDPPMNLDD-VMEQIAEAHRKPDAIESVIRDGGGFDLEVQVVRPDGERHWARL-IGQS
EGRAPMSTRLTGTLQDITQRRQIEEALRSQARTDPLTGLFNRDGILGELERRLGD--DA-TGTTVIYVDLDRFKLVNDLLGHAAGDHLLVNAARRLERCV
GDTGLLARFGGDEFLVVTDQRAGGMAELLAERITRAFGDSFRYAGEEFTITTSVGLARHPEHGRTVQQLVNNADAAMYAAKRKGRNTWQVFNPELAQQQH
DRVQIEAQLRRALDNGEFRLVFQPLVSLGDGRVRTAEALIRWHNPTLGEIPPDHFISHAETTGDIVRIGAWVIEAACRQMAAWRDAGLPLERVAVNVSYR
QFLTEDLVQTIAHALREHGLPGSALELEFTERVLIEDAPDTLNTFEALRALGVVLTIDDFGEGYSALNYLRRLPIHGLKLAHSFLQGVPANPSDVAICQA
VAGMARGLGLDVVAEGVESPAQRDFLLGLGIATGQGFLFSPGLEPDSFAAYLRQAG----
>tr|A0A091BHE9|A0A091BHE9_9GAMM Uncharacterized protein OS=Arenimonas malthae CC-JY-1 GN=N790_03435 PE=4 SV=1
------------------------------------------------------------------------------AEQNLKTLLMAMDKGVLVQGPD
GQAISANAAAMRILGLPE-QDSHWH-EWV---DWPLRFGEMP--AQRAIKTGKFV--TLLYHLGRKQLTWVSATCVPQQPHSDKPYQVVSLFSDVTELKR
DSALFLR---TQALARIGGWEWDGGRERLYLTDETLRILGRRDDPPRTLDE-ALRQVAPHDRPKEALESVLRDGGGLDLEIRIVRPDGQSTWARV-IGQA
EGRAPMTARITGTVQDITQRRQIEEALRSQARTDPLTGLYNRDGILTELERRLGE--GG-EGSTVVYIDLDRFKLVNDLLGHAAGDDLLVNAARRLERCV
GERGLLARFGGDEFLVLADTRDDREAERLAERITRAFGDAFRYAGEEFTITTSVGLARFPEHGATVQQLVNNADAAMYDAKRRGRNTWQTFTPELARQQH
DRVQVESQLRRALDNEEFRLVYQPLVNLADGTVRSAEALIRWRNPALGEMRPDHFINHAETTGDIVRIGAWVIQVACRQMAAWRDAGYPLERVAVNVSYR
QFLTEDLVQIITEALAEHDLPGHMLELEFTERVLIEDAPDTLTTFEALRALGVVLTIDDFGEGYSALNYLRRLPIHGLKLAQGFLRGVPGNASDAAICQA
VAGIAQALGLEVVAEGVESSVQRDFLLGLGIHRGQGFLFSQALEADAFGAFLRQSN----
>tr|A0A087MLC8|A0A087MLC8_9GAMM Uncharacterized protein OS=Arenimonas donghaensis DSM 18148 = HO3-R19 GN=N788_00500 PE=4 SV=1
------------------------------------------------------------------------------AEENLNTLLSVIDKGVMIQDHE
GNVLSANAAAMRILGLSE-EDTRWQ-DWV---DWPLRFGDMP--VMRAARTGRII--TLMYHTGRKQLTWLSATSVPQRPGERTPYRVISLFSDVTDLKR
DSALFLR---TQALARIGGWEWDGGRERLYFTDEALRILGRRDDPPRTLRE-ALTQVVPADRPREALQSVLRDGGAFDMEVQLRRPDGRSHWARL-IGQS
ESRVPMTARITGILQDINQRRQIEEALRSQARTDALTGLFNRDGVLTELERRVME--GE-EGLTVVYIDLDRFKLVNDLLGHAAGDQLLINAARRLESCA
GDDDVLARFGGDEFLVLASNKDDGAAEALAARITQAFGDSFRYAGEEFTITTSVGLARYPEHGATVQQLVNNADAAMYDAKRRGRNTWQTFTPELARQQH
DRVQVEAQLRKALDNGEFRLVYQPLVNLADGHVRSAEALIRWRNHALGELSPEVFINHAETTGDIVRIGGWVIQTACRQMAAWRKAGLAPARVAVNVSYR
QFLTEDLVPLVAACLQENQLPGELLELEFTERVLIEDAPDTHRTFEGLRKLGVVLTIDDFGEGYSALNYLRRLPIHGLKLAQPFLRGVPGNESDAAICQA
VAGIAQALGLDLVAEGVESSVQRDFLMGLGVRTGQGFLFSPALDPDAFAAYLRQTG----
>tr|A0A091B9E9|A0A091B9E9_9GAMM Uncharacterized protein OS=Arenimonas oryziterrae DSM 21050 = YC6267 GN=N789_04100 PE=4 SV=1
------------------------------------------------------------------------------AERRYRQLMESIDKGILIQDAN
GRILSGNPAAMRMFGIDD-DSDSLD-KWV---DQPVPFEELP--PVRALRSGLTI--TLLYHHRDKQLTWLSVTSVPQAADGSRPHMVISLFSDVTSLKR
DSALFDR---AQSLASIGGWEWDAARGGLYLTNEALRIMGREDDPPSDLPE-ALRLVAPHDRPAQAVSRLLREGGSFDLEVFGHRPDGQALWARM-IGEA
ERRGPMTTRITGTVQDITQRKLEEDRLRVLSRTDPLTGLLNRDGMMSELATRLAR--ED-GDTALFYIDLDRFKMVNDVLGHGAGDQTLIAAARRLQRAV
GDGAALARFGGDEFLVVADPTSLDTPERVAARINAAFADSFRVGEEDFSITASVGLACASDAGRHPEELLSNADAAMYDAKRRGRNTWQRFNPGLARRQQ
DRVQIESQLRRALDDDEFHLVYQPMVSLHDGRVRGAEALLRWRHRTLGEIMPDNFIGQAEATGDIVRIGAWVIGQACHQICAWRKSGLPIERVSVNVSHR
QFLGEELPQIVAAALGKCDLPGSILELEITERVLIEEAPDILATFAALRALGVSLVIDDFGEGYSALNYLRRLPIQGIKLSRQFLQGVPENRSDVAICQA
VAGMAKGLGLSVVAEGVETIAQRDFMLDLGIEQGQGFLYSRGLPPLEMTEYLRRPS----
>tr|A0A021W992|A0A021W992_9GAMM Uncharacterized protein OS=Lysobacter capsici AZ78 GN=AZ78_13270 PE=4 SV=1
------------------------------------------------------------------------------TEMRFRELVESIDRGVIVQDHS
LRIIYANSAAMLLLSLHS-MSDSSG-DWV---DHELATDQYP--SQIALTTGCVV--TVLYHRERRELIWLAVTAVPQPPGGDRPHQVFALFSNVTALKR
DSALFDR---AQALAHIGGWEWDAGRDRLYLTFEAARIIGREA-EPEQIDD-LLECLLPLDRHRNALERTLAGGRGIDMELQGMRADGSGFWVRA-IGDA
SAADPVRQVLTGTLQDITERKHEEEQLRIQARSDPLTGLLNRDAVQAELERRLDI--YPHSPLAVLYIDLDRFKVVNDVLGHAAGDRLLASAARRIRLAA
GDQALIARFGGDEFLLVCSLDDDLRGERLADAILEIFGDSFRVDGEEFSITASIGIAQAPLDGRTAQQLIQSADVAMYDSKRRGRNSWQAFTPELAEQQL
HRLQLETHLRRAVHNDEFHLVYQPQVDLSDGRVVAIEALIRWRNRSLGEMRPDRFIDHAETTGDIVGIGGWVLHEACRQLRAWRDEGLQIERVAVNVSYR
QFLGDDLANNVGAALAEYGLPGSALELEFTERVLIEDAPDTVRTFTRLRELGVSLSIDDFGEGYSALNYLRRLPIHGLKLSQLFVQGVPDNQSDVAVCQA
VTGIARSLGLGMVAEGVETERQRVFLRELGVLIGQGFLFAPGLAPDDLRDYCRAQK----
>tr|A0A0A2WJM2|A0A0A2WJM2_9GAMM Diguanylate cyfclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Lysobacter dokdonensis DS-58 GN=LF41_484
------------------------------------------------------------------------------AEVRYRELMEVIDKGILVRKAD
GRVAYANPAAMRILDIPK-ASKALD-HWF---DQELDDQELP--SFRALRTGTIS--TVLLNLNTRRLVWLSITSVPQAPGQDHPQQVLSLFSDVTAFKR
DITLFDR---VQDLAHVGGWEWDANSEHVYLTGEAQRMLGLAR-ASASISE-LQACLRETERKRDALTRAVEHGEGFEMDLQGIRADGHTLWIRI-IGES
EAADPTGTRLTGTFQDITETKQAEETLRVQARTDPLTMLLNRDAVLEELEARLSD--RSHSDVAVLYIDLDRFKVVNDVLGHAAGDQVIASAARRIQRAV
ATEGLIARFGGDEFLVVCQTGDDERPQRLAASILDAFGDAFRMAGEEFTITASVGIARAPEHGDRPQLLIQNADVAMYDSKRRARNGWQDFSAALAEQQQ
QRLQMETHLRRAVDNREFKLVYQPQVELATGRIIGAEALIRWRNDTLGEMRPDHFIGHAENTGDIVRIGGWVLREACQQMRRWRDEGLPIERVAVNVSYR
QFLAEDLAETVSEALASAGLPGDALELEFTERVLIEDAPDTLTTFAGLRMLGVLLSIDDFGEGYSALNYLRRLPIHGLKLSQQFLTGVPHNTSDVAICQA
VAGIAQSLGLGLVAEGVENDAQRQFLIRLGVKIGQGFLFAPGLTPDELALRIAHHE----
>tr|A0A023Y4D2|A0A023Y4D2_9GAMM Uncharacterized protein OS=Stenotrophomonas rhizophila GN=DX03_10840 PE=4 SV=1
------------------------------------------------------------------------------AESRYRLLMESIDKGVVLFDSH
LRVVSANPAAHRILGTPGNGSAAPD-DWV---DHPLTREQWP--AAVSLRTGRII--TIVYHRPRGRMIWISTTNVPVGTGRDCPDHVFGMFSDITELKR
TNALFDR---AQSLAHIGGWEWDRGLQRLYLTDEANRILGQEL-PLHDMAH-LLECLRVDDRSQQALLDVIDKQVPFELELQGQRGDGHSFWVRM-IGEA
EAGDVDAARIAGTVQDITARKQAEETLRIQARTDPLTGIMNRDAVLNDLAARMAN--PTHCRVAVLYIDLDRFKTVNDLLGHNAGDELLIDATRRIATAI
GTEGLLARFGGDEFLVVCDTRDQDQPERLAEAITRGFSTPFRFGSDEFAVTTSIGIARAPQDGLRPQQLIQNADIAMYDCKRRTRNGWQVFSPELAQRQH
DRLQIESRLHRALDDDEFHLVYQPQVSLHDGRMVAAEALIRWRNSQLGELRPDIFIAHAESTGDIVRIGLWVLREACRQIRQWQDAGLGIVRVAVNVSYR
QFVGEDLARHVRQVLDEFGLPGSALELEFTERVLIEDAPDTLQTFARLREMGVQLTIDDFGEGYSALNYLRRLPIHGLKLSQLFVEGVPGNRSDEAVCEA
VCGIARSLGLGLVAEGIESEPQRRFLQALGVTVGQGFLFAPGLAPDEFARRLTPRH----
>tr|A0A031HEN5|A0A031HEN5_9GAMM PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Stenotrophomonas sp. RIT309 GN=BW38_01131 PE=4 SV=1
------------------------------------------------------------------------------AESRYRLLMESIDKGVILFDRD
LRVLSANPAAHRILGLTGGVGADPE-AWV---DHPLTQSQWP--TSRCFQAGRVI--TIIYHRPRGRMLWLSTTNVPVGNGCDQADHVYAMFSDITELKR
NNTLFAR---AQSLAHIGGWEWDRGLQRLYLTDEARRIVGQPA-DLEDMPD-LLDCLRSDDRAAQALADTIEHRSSFGLELQGQRRDGHSFWIRM-IGEV
SAGDVDAARITGTVQDITERKQAEETLRVQARTDPLTGIMNRDAVLSDLGVRMDS--PSHDRVAVLYIDLDRFKVVNDLLGHNAGDELLIEATRRIATAI
GTEGLLARFGGDEFLVICDLRDQDQAEQLAERITAAFSAPFQLGSDEFPVTASIGIARAPRDGNRPQQLIQNADTAMYECKRRTRNGWQVFSPELAQRQH
DRLQIESRLHKALDGDEFHLVYQPQVNLRSGATIACEALMRWHNIQLGPMRPDLFIRHAEHTGDIVRIGQWALREACRQVRQWQDDGLGLVRVAVNVSWR
QFVGEDLARWVRQVLDEFGLPGSVLELEFTERVLIEDAPDTLRTFARLREMGVMLTIDDFGEGYSALNYLRRLPIHGLKLSQLFVEGIPRNRSDVAVCEA
VCAIARSLGLGVVAEGVETEPQRQCLLDLGVTVGQGFLFAHGLPAADFERRLRRAR----
>tr|A0A0A0M7J1|A0A0A0M7J1_9GAMM Uncharacterized protein (Fragment) OS=Lysobacter defluvii IMMIB APB-9 = DSM 18482 GN=N791_12250 PE=4 SV=1
------------------------------------------------------------------------------VELRFREVVENVQQGIVVRDHA
GLVVYVNSEALRMFDQRPVNAFGGP-ELV---DHEVPPERLP--SALALAGNCPA--QVLFDREARTLSWVSVTAVPHDTGNGRPRFVMTFYTDVTGLKR
DSALFAR---AQALASIGGWEWDTGRDRLYLTREARRILGRDP-APSDLEG-LLECLLEPDRRRQAFDAAVQRGWGFGLELQGNRG-GRPFWMRI-MAEV
GAHGPLSARITGTIQDVTRQKQDEETLRVQARTDPLTGLLNRDAIRAELAERLAD--PVQRALAVLYVDLDRFKTVNDVLGHAAGDRLLVAAANRIRAVV
GCEGLLARLGGDEFLLVCSLADDDRALRLAERILDSFRASFRVHDEEFAVTASIGLAIAPEGGTEAQLMIQNADAAMYSSKRRGRNGWQVFTPELAAQQQ
RRLQVETQLRNAVGNGELTLYYQPQVDLASGRTVAAEALVRWNNPALGAILPGEFIDLAENTGDVVAIGDWVLREACRQLGRWRGRGMALERIAVNVSYR
QFLTGDLPVRVAEALEEFGLSGDMLELELTERLLVEDVPETAEAFAALQALGVRLSIDDFGEGYSALNYLRRLPIHGLKLSQLFVQGVPGNESDVAVCEA
VIGIARSLRLGLLAEGVETGAQRDFLVQRGVTLGQGFLYAPGLPADEFEARFGRSA----
>tr|Q2W154|Q2W154_MAGSA Putative uncharacterized protein OS=Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) GN=amb3617 PE=4 SV=1
-----------------------------------------------------------------------------DGKTLIRAMLDSSTDGIVLVNAE
GTILAVNAAASAIFEKN----SGKA-IWLPDSVAPMRRGI-D--RVLDRRETVESHHKLFVHMHLV------------ADSVGQRDRVAIFSRDVTQSHQ
RRQQLRKLETVMITDSHGA--IEYVN----RAFV--LVSGYSEDEVLGRNPRLLKSGETVASLY--MWHCLASGATWQGELCNRAKDGSLFWEYATISPI
RDDDGVVTHFMAVKENITQRKETEQQLVHQATHDTLTGLPNRLLLEDRVHHAIEVAKREGRRIGLMFLDLDRFKIVNDSLGHVAGDELLKVVSDRLRHTL
RRSDTVARLGGDEFVVVLTHFQSTELAEVAEKISAALDEPVELSGHKVHVGASIGIAIYPDDGDNFNALMKDADTAMYRAKQKGRNTFCFYDSNMNDEAL
DRLKLEEALRRALVRGEFQLFYQPQVDLQTGRTSGVEALIRWNSPERGQVSPALFIPVAEESNLISMIGWWVLEESCRQIAAWREAGLTGIKVAVNVSGR
QFLNHALVECISDLMAQYAVLPSQLEIELTESTVMAEPDRAIEQLTRLREIGIQVSVDDFGTGYSSLSYLKRLPLSTIKVDRSFVRDVNNQSDNAAIVSA
ILGLADALDMSIVAEGVETEGEEQHLKDAGCIKVQGFRYAKPMPADQLAAWMLRQG----
>tr|A0A084Y2X3|A0A084Y2X3_9PROT Bacteriophytochrome cph2 OS=Candidatus Accumulibacter sp. SK-01 GN=cph2_3 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------RNLNKEIDIRRA
AEKQLKLAAEVFDNAMEGIMITDANKRILAVNGAFTRVTGYSADEIVGQTPSILNSGRQDKAFYAALWTALQLETHWQGELWNRRKNGEIFPEWLSITAV
FDEQNAVSHYVAVFSDLTQRKAAERRIDHLAFYDPLTDLPNRRLLLDRLQRALIASARTGRGGALLFIDLDNFKSLNDIVGRDQADLVLQQVAQRLAGCV
RASDTVSRPGSDEFVVMLEDLEARQAESVGEKLLATLSQVYPLAGYAHHSTVSIGIALFADHQEVVDELVQRAESAMHHAKRAGRDTLRFFNPTMQAVAT
ARAALEASLHEAVQKEQFVLHFQAQVD-SSGRVIGAEALLRWQHPERGLVSPTEFIPLLEESRLILPLGQWVLETACDRLAAWAARPESGLTLAVNVSAR
QFHDDAFVDYVLAALARSGARPQRLKLELTESLLVKDVQEVITKMTIIKAKGVHFSLDDFGTGYSSLSYLQRLPFDQLKIDQSFIRNILTDPNDAAIARM
VVVLAESLGLAVIAEGVETEAQKDFLAGQGCHVYQGYLFSRPLPAEGFEEFAQRAFIPN-
>tr|V6F3X8|V6F3X8_9PROT Uncharacterized protein OS=Magnetospirillum gryphiswaldense MSR-1 v2 GN=MGMSRv2__1968 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------RGVGRDITEQKQ
AEKRLKLYADLFEQTNEAMLVTDSDNRIIHTNAALTRITGYSAEELLGCNPRILSSGQTSAEVYVEMWAALGSNGYWSGEIWDRRKNGSVYPKWLTISAM
RDAEGVVTHYIGLFIDITERKQTEALIDHLAHHDNLTKLFNRHSLQGRLGQALATAQRTRAPLAVMFIDIDRFKRVNDTLGHHTGDLLLIEVAARLRECV
RESDIVARPGGDEFVVVLTGMEDRDAFPVGNQILQMLAQPYHLANQVLQITPSIGISIYPDDGISVDDLMKNADMAMYHAKSQGRNNLQFFTAAMNAAAT
ERMAMELELRQAIETGQLELHYQPQVCTHNGAACGVEALVRWRHPQRGLISPLAFIPLAEETGLIEPLGAWVLEEACRQFAIWRAEDAPILRIAVNLSAQ
QLRSPGLLAQVEDVMARYQLIPGELELEVTESEAMSDPERSFDTLRALRDLGVQLAIDDFGTGYSSLSYLKQLPVQILKIDRSFVKDIETDENDASICAS
ILALAHSQGLKVVAEGVETMAQREFLAAHACEYLQGYLFAKPEPAEVCLGRLRELSIAA-
>tr|W1RRQ5|W1RRQ5_9SPHN Diguanylate cyclase OS=Sphingobium sp. C100 GN=C100_20465 PE=4 SV=1
--------------------------------------------------------------------AQALETALTESREHYRWSVELSPQVPWTAAPD
GRIEEVGPRFTDLTGLPVEQALGLG--WL-RVLHEEDVPRVSALWTDHLVSGDPIDVDYRIKLRDGGYRWMRARAGARRDDQGRIIRWYGTLEDVHARRV
AQRDLAESELAVQSARLGIWDFDAATGTRNWSAELRRMLGVARDVEPTAGLALSLVHPEDRDRLRAMLESVAAGTLFEDRI-HRANDGALRWIKSTSWTT
RTEAGRPMRIIVTFLDVTEEHDSEERIRWAATHDPMTRLPNRALWQAGLDSMAEEARARGESFALLLLDIDDLKRTNDSLGHDAGDALLCAFAARLAAAA
PPDAVIGRLGGDEFGLIAPSLHNSLVEAWGSALIEELRRPHLHQGRSLDCGVSMGAALFGADGDRGDELLKAADLALYASKAAGRGRLTLFHSSLRAEAQ
QRGSMIHMARAVIADDLLMPYYQPKVDLRTRKVTGYEALLRWRHPRLGVQLPGSIAAAFDHGEIAVALTRKMLAAVLHDLVRWLDAGYDPGRIAINASAA
DFTHSGFADFVLERLLAANVPTDRLEIEVTETVFLGRGADQASALRCFAHAGVRVALDDFGTGYASLSHLKHYPVNVLKIDRSFVSNMDHDAGDAAIADA
IVKLGASFGMEVVAEGVETEAQAQLLRDRGCPIGQGFHLGRPKPFDAIRPGN--------
>tr|T0HZ60|T0HZ60_9SPHN Diguanylate cyclase OS=Sphingobium lactosutens DS20 GN=RLDS_05045 PE=4 SV=1
----------------------------------------------------------------------LLSAAVTESRDHYRWSVALSPQVPWTAAPD
GAIEEVGPRLAEMTGLSDDEVRGFG--WI-KMLHPDDAPHVRAVWDRHLASGEPVDVDYRVRLRSGDYRWMRACAAARRDADGRIIRWYGSLEDVHERHM
AERNLAESELAIQSAGLGIWDFDSRTGQRSWSPELRAMLGVSPHAEPTAELILSLVHPDDRSHLRGLMSAVVSGTMFEGRI-RRMTDGAFRKLKSTGWLT
RCETDRSTRIVVTFLDVTEQYDSERRIRWAASHDAMTRLPNRTLWQQKLEEMAQAARRSGESFALLLLDIDDLKRTNDSLGHDAGDALLCAFAERLQAAA
PPDAVIGRLGGDEFGLLSSALGDARVEAWGKALIETLRRPHMHEGRSLDCGVSMGAALFGGDGSEGDELFKAADLALYASKAAGRGRLTLFHSTLRAEAQ
QRSSMIHMARQVIHDDLIMPYYQPKVDLRTRMITGYEALLRWRHPRLGVQSPGSIAAAFDHGEIAVGLTQTMLDKLLHDMVRWLDAGLDPGSVAFNASAA
DFTHAGFADSVLERLAQAHIPTRHLEIEVTETVFLGRGADQASALRCFAKEGVRVALDDFGTGYASLSHLKHYPVDVLKIDRSFVSNMDNDVGDAAIVDA
IVKLGDSFGMEVVAEGVETEGQAQLLLAHGCPIGQGFHLGRPQPFDVVTAKM--------
>tr|N1MGY5|N1MGY5_9SPHN Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Sphingobium japonicum BiD32 GN=EBBID32_51
--------------------------------------------------------------------ARALERALAESREHYRWSVELSPQVPWTAGPD
GAIEEVGPLWLNMTGMTAQQALGAG--WL-AALHPDDLARTIALWSAHLETGAPIDIDYRIRLRDGGYRWMRARAAARRDAQGQIVRWYGTLEDVHAQKL
AQHALAESELAVQAARLGIWDFDTISGARRWSPEFRDMLGLSEDHPATSELALSLVHPDDRETLRGMLASVADGAVFEARV-YRANDGALRWIRSSGWTT
RSESGRALRVIVTFLDVTDQRDAEDRIRWAATHDPMTRLPNRALWQATLDEMAERQARTGNRFGLLLLDIDDLKRTNDSLGHDAGDALLCAFARCLAAIA
PPDAVLGRLGGDEFGLIAPSLTNAALEAWSAKLIESLRIPHIHNGRSIDCGVSIGGAVFGDHGDRAADLLKAADLALYASKAAGRGRLTLFHSDLRAQAQ
QRSSMIGMARKIIADRLVTPYYQPKVDLRSGRVLGYEALLRWHHPRLGLQLPGSIAAGFEDAEIAVALTGQMLDAVLRDVRNWLHAGYDPGRIAVNASAA
DFARDDFAERVLEQLALFTVPPEHLEIEVTETVFLGRGAGQGHVLRHFSDAGVRIALDDFGTGFASLSHLKQYPVDILKIDRSFVSNIEQDAGDAAIVDA
IVKLGVSFGMDVVAEGVESAAQADRLLAHGCIIGQGFHLGRPQPFAVITPPK--------
>tr|Q1N802|Q1N802_SPHSS Sensory box/GGDEF family protein OS=Sphingomonas sp. (strain SKA58) GN=SKA58_11583 PE=4 SV=1
----------------------------------------------------------------------LLSAAVAESRDHYRWSVALSPQVPWTAGPD
GAIEEVGPRFAEITGISKDEALGQG--WA-TVLHPEDETRVLGIWDRHLANGEPVDIEYRVRLRSGHYRWMRACAAARRDADGRIIRWYGSLEDVHERHM
AEHDLAQSELAIQSAGLGIWDFDSRTGQRSWSPELRAMLGVSPDVTPTTELALSLVHPDDRPRLQDKLAAVAGGGLFEDRI-YRATDGALRWIKSTGWTT
RCDTDGSVRIIITFLDVTEQQDSERRIRWAATHDAMTRLPNRSSWQQTLDDMAKAARRSGDSFALLLMDIDDLKRTNDSLGHDAGDALLCAFAERLQAAA
PPDAVIGRLGGDEFGLLSSTLSDTRAEAWGKALIETLRRPHMHEGRSLDCGVSMGAALFGGDGSEGDELFKAADLALYTSKAAGRGRLTLFHSSLRAEAQ
QRSSMIRMARQIIADDLIMPYYQPKIDLRTRMVTGYEALLRWCHPRLGVQLPGSIAAAFDHGEIAVGLTQTMLDKLLRDIIRWLDAGLDPGSVAFNASAA
DFTHAGFADSVLERLRLANIPTRHLELEVTETVFLGRGADQATALRCFAKEGVRVALDDFGTGYASLSHLKHYPVDVLKIDRSFVSNMDNDAGDAAIVDA
IVKLGDSFGMEVVAEGVETELQAQLLLAHGCPIGQGFHLGRPQPFDVVTAKM--------
>tr|A0A013WGF3|A0A013WGF3_9SPHN Diguanylate cyclase OS=Sphingobium sp. Ant17 GN=BF95_17760 PE=4 SV=1
--------------------------------------------------------------------ARALETALAESREHYRWSVELSPQVPWTASPD
GNIEEVGPLWETLTGLTLEQTLGSG--WT-TAVHPDDLAHVVSVWEVNLTSGDPVDVDYRARLRDGSYRWMRSRAAARLGIGGKIIRWYGTLEDVHAQKL
AQQALYNSELAVQSAKLGIWDFDVATGARTWSAELRAMLGLAEDQPATSELALSLVHPEDRHILGGMLAAVASGTAFEARI-ERADDGALRVIKSRGWTM
LSEQGRPLRIVVTFLDITEEHDVEQRIRWAATHDPMTRLPNRALWQARLEDMARDAKEQGAHFGLMLLDIDDLKRINDSLGHDAGDALLCDFAKRLAAMA
PPDALLGRLGGDEFGLIAPSLADAAMEAWSAKLTANLRQRHVHRGRSLDCGVSMGAALSGDHGEVAAELLKAADLALYSSKAVGRGRLTLFHSELRAEAQ
QRSSMIRMARQVVAENLIIPYYQPKIDMRSGRVLGHEALLRWRHPRLGVQLPGSIVAAFDHGELAAALTRRMLDAVLRDMRRWLDTGFDPGRIALNASAA
DFMQDDFVDSVLEQLSRYDIPPCHVEIEVVETVFLGRGADHACALRGFAQAGVRIALDDFGTGYASLSHLKHYPVDVLKIDRSFISNITQDAGDAAIVDA
VVKLGSSLGMEVVAEGVETAEQAELLLGHGCFIGQGFLLGRPQPFADIRPLR--------
>tr|A0A081RFQ5|A0A081RFQ5_SPHCR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sphingobium chlorophenolicum GN=BV95_01716 PE=4 SV=1
--------------------------------------------------------------------RRALADALAESRQHYRWSVELSPQVPWTAAPD
GEVEEIGPRWRDLTGIDPEEAKGSG--WI-DSLHPDDVERTTSIWMEKVRSGDPVDVDYRLRLVDGSYRWMRSRASARRDAKGRIVRWYGTLEDIHAQKL
AQRELADSELAVQSARLGIWDFDAVAGTRTWSQEFRSMLGLSDTEPATSELALKLVHPEDRPRLAVMLDAVASERMFEARI-YRADTGALRWIKSVGWRS
FSDSGRPLRVIVTFQDVTEERDSEDRIRWAATHDPMTRMPNRALWQATLEEMTEQARRRGDSFGLILVDIDDLKRTNDMLGHDAGDALLCGFAQRFAACA
PADAMVGRLGGDEFGMIAPSLTSAALTAWSAELLGGVRTPYVHNGRSLDCGISIGGAVFGEHGDNAAELLKAADLALYASKSSGRGRLTLFQSQLRAEAQ
QRSSMIHMARQAIADDLVVPHYQPKADMKTGRILGYEALLRWEHPRTGVHAPDTIAAAFDNAEIAVELTEIMLAKVVRDVDRWLRSGYDPGRVAINASAA
DFMQHDFADHVLAHLARYAVPPQRFEIEVTETVFLGRGAEQERALHRLSAAGVRIALDDFGTGYASLSHLKQYPVDVLKIDRSFISNIERDAGDAVIVDA
IVNLGNSLGMEVVAEGVETAGQADLLIARGCIIGQGYLMGRPRPWAAVRSQA--------
>tr|T0IY07|T0IY07_9SPHN Uncharacterized protein OS=Sphingobium ummariense RL-3 GN=M529_19955 PE=4 SV=1
--------------------------------------------------------------------LDALEAALRESRQHYRASVELNPQVPWTAGPD
GAIEEVGPRWAALTGIDTDAALGVG--WM-DSLHPDDAERVSGIWADHLQSGLPVDVDYRVRLKDGSYRWMRARAAARRDDRGAIIRWYGSLEDVHAQRL
AQQALSESELAVQSAQLGIWDFDAVTGVRTWSPELRAMLGLADDVPATSELALSLVHPDDRAELQGMMSAVACNSLFEARI-HRADDGRLRWIRSTGWSS
RLDGERPLRLIVTFLDVTEEREAEVRIRWAATHDPMTRIPNRTFWQEGLEAMARQARADRQGFGLMLLDIDDLKRTNDALGHDAGDALLGEFVARLRNVV
PTDALIGRLGGDEFGLIAPSLATSALEQCAARLIEAMREPHVHDGRSFACGVSIGAALFGEHGGEADELLKAADLALYASKAAGRGRLTLFHPALRAEAQ
RRTSMIHMARDAVARDMVVPHYQPKVDLVTGRVLGYEALLRWRHPSLGILPPASIAAAFEDGELAAALTGRMLDAVTADLRGWLDGGIDPGRIAVNAAAA
DFQCGDFAERVLERLARCDLPPERLEIEVTETVFLGRGAHHERALDVFARAGVRIALDDFGTGYASLTHLKQYPVDVIKIDRSFVSHIEEDAGDAAIVDA
IVKLGTSLGLEVVAEGVETEGQAALLIGHGCSVGQGFLLGRPQPASMLFPDM--------
>tr|T0GFG1|T0GFG1_9SPHN Diguanylate cyclase OS=Sphingobium sp. HDIP04 GN=L286_20940 PE=4 SV=1
--------------------------------------------------------------------RHALAAALAESRQHYRWSVELSPQVPWTASAS
GDIEEVGPRWQELTGIAPARARGRG--WI-DSLHPDDVDRTLAVWSEKLRTGDPVDVDYRLRLSDGGYRWMRSRASARRDAKGRIVRWYGTLEDIHAQKL
AQRELANSELAVQSARLGIWDFDAVAGTRTWSREFRTMLGLSDTEPATSELALRLVHPEDRPRLAEMLDVVASERMFEARV-YRADTGALRWIKSVGWSS
FSDSGKPLRVIVTFQDVTEERNSEERIRWAATHDPMTRMPNRALWQATLEEMTEQARRTGESFGLILVDIDDLKRTNDTLGHDAGDALLCGFAQRFASCA
PADAMIGRLGGDEFGMIAPSLASAALSAWSAELLGGVRVPYVHNGRSLDYGISMGGAVFGEHGEDAAELLKAADLALYASKSTGRGRLTLFQSQLRADAQ
QRSSMIHMARQAIVDDLVVPYYQPKADMRTGRILGYEALLRWEHPRTGVHSPDTIAAAFDNAELAVELTEKMLAKVVRDVDRWLRAGHDPGRVAINASAA
DFIQHDFADYVLAHLARCAVPPQQFEIEVTETVFLGRGAEQERALHRLSSAGVRIALDDFGTGYASLSHLKQYPVDVLKIDRSFISNIEQDAGDAVIVDA
IVKLGSSLGMEVVAEGVETAGQVEMLIARGCTIGQGYLMGRPRPWAAVRSRA--------
>tr|J2WRQ7|J2WRQ7_9SPHN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Sphingobium sp. AP49 GN=PMI04_00840 PE=4 SV=1
--------------------------------------------------------------------AHGLAHALAESREHYRWSVALSPQVPWTATPD
GRIEEVGPRWQDLTGMSATQAMGAG--WL-EALHPDDVERTLTLWADRLQSGEPVDIDYRIRLRDGDYRWMRARAAARRDDAGGIVRWYGTLEDIHGQKL
AQQALSQSELAVQSARLGIWDYDAVSGERRWSPELRAMLGLTPDHPATAELAMALVHPDDRAQLKAMMDSVAAQTLFEARI-YRADTGAMRWIRSTGWST
RTDAGRPLRVIVTFLDVTEQRDAEERIRWAASHDPMTRMPNRAMWQAALEDMAEQARIDGRRFGLMLFDIDDLKRVNDSLGHDAGDALLCGFAQRLAVAA
PADAIVGRLGGDEFGLISPSLMDATLRACSMALLDTVRGPFAYAGQLLETGVSIGGAVFGEHGDEANELFKAADLALYASKASGRSQLTLFHSELRAEAQ
QRSSMIHMARQVIARDLVTPYYQPKVDMRSGRILGYEALLRWHHRRLGVQSPATISAAFDHGELAVALTERMLNAVLRDIARWLQAGRDPGRVAVNASAA
DFAQGDFAEHVLQKLAEHGVPARHFEIEVTETVFLGRGADQGRALERFARAGVRIALDDFGTGFASLSHLKQYPVDVLKIDRSFVSHITDDRGDAAIVDA
VVKLGSSFDMEVVAEGVETAEQAALLLGHGCQVGQGYYYGRPQAEQLLFPIA--------
>tr|A0A084ETD3|A0A084ETD3_SPHYA Diguanylate cyclase (GGDEF) domain-containing protein OS=Sphingobium yanoikuyae GN=CP98_00676 PE=4 SV=1
--------------------------------------------------------------------AELLETALAESREHHRWSVELSPQVPWTATPD
GAIEEVGPRWRDLTGSSPEQAMGAG--WI-NALHPDDMDRTLALWRERLQSGDPVDVDYRLRLRDGSYRWMRARAAARRDGRGAIIRWYGTLEDIHNQKL
AQQAVAESELAVQSARLGIWDYDARSGQRSWSAEFRAMLGLTADAPATTELALSLVHPDDRHKLKAMMDGVAANVLFEARV-HRADNGALRWIRSTGWAT
RTEVGQLRRIIVTFLDVTEQRDAEERIRWAATHDPMTRLPNRTLWQGVLEELADQARPTGAGFGLMLFDIDDLKRINDSLGHDAGDALLCGFAERLAAAA
PADAVVGRLGGDEFGLIAASLVDATVQACSQAILDKMRVPFAYQGQLLEAGVSVGGAVFGEHGDDAHELFKAADLALYASKASGRSRLTMFHSQLRADAQ
QRSSMIHMARQVIAERLVEPYYQPKVDMRSGQVLGYEALLRWQHPRLGVQAPATIAAAFEHGELAIRLTDLMLDAVLHDMAAWLRMGFDPGRVAVNASAA
DLLQADFADHVLARLDQHGVPAQNFEIEVTESVFLGRGADQARALDRFARGGVRIALDDFGTGFASLSHLKQYPVNVLKIDRSFVSHVDSDAGDAAIVDA
VIKLGSSFRMEVVAEGVETAEQAALLLQHGCHIAQGYHYGRPQPAASVLAAC--------
>tr|I4YRZ6|I4YRZ6_9RHIZ PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Microvirga lotononidis GN=MicloDRAFT_00032880 PE=4 SV
--------------------------------------------------------------------QVDLAQELSRTGRRHRALAEASAAIIWRVTPD
GCSLE-GEGWDAFCGVAVEKGQRGW--WL-QLVHPADRERVSAAWHAALRDGEPYACEFRVRHVGGAYRWVADRGVPLRDEDGIIEEWVGTISDIHERKQ
AEEALRDSELALETTSTGIWDADLVTGGRQWTPETRRILGISAEAPVTRDSFLDCVHPDHRAEVESTFF-VDWPAEYSGRI-IRADNGEERWVAATGRTL
LDENERPVRKIGTLQDITPHKRAEEQAWRSSNHDPLTGLPNRALFQQRLEQALGCAGHSGTNASLLLIDLDHFQAINDTLGHDAGDALLKETAARLSAMI
RACDTVARFAGDQFMVLIVEPLTEHAVRFAQCVTETLRQPFSYAGRRLTGRASIGIAAFPDHASRSTELMQDAEFALRHAKEQGRDRAVTYSPALRLASE
QRVGLGRDVHAALARDEFIPHYQPKVCLATGSIVGFEALARWHHPTQGLLTPGYFGTAFADPELATAIGRQINAKVASDMRGWLDAGLPFGRVAVNLSPS
AFNEPGLADELLMILEHTGVPARHFEVEVTETVFLGRSSDHSSILMQLHQQGVRIALDDFGTGYASLTHLKQFPVDHVKIDQSFVRELERDEGDEAIVSA
IIGLCRKLSIEVTAEGVETPGQAQRLRGLGCHRAQGYLYAKPVACTQVPSLL--------
>tr|V2IVQ9|V2IVQ9_9BURK Diguanylate cyclase OS=Cupriavidus sp. HPC(L) GN=B551_0210545 PE=4 SV=1
--------------------------------------------------------------------IRRAESALRESEAHYRHSVELNPQVPWTADAQ
GLVSEAGPRWEELTGRSVEQGKGTG--WA-EQVHPDDLPDTLRRWRDSVDTGQPFDHEFRLRMQAGQYRWFRSRAAARRDEDGKVVRWYGTLEDIDDHKR
AEAALRESESILENSPNCIRVLDLDGRVLYANATAYRLLELDDDEPVLGQRWVDLVPEPCRADAGAALDAARSGGI---TIRRHTRNGAVQWLDTVTASI
PGEQGRPARLLAISLDATEARQARQRLAYLSRHDALTGTPNRVALREHLERLLRE----RSRAALHCVDLSGFKGVNDTFGHAVGDAVLRQVADRLRGCL
TEADTVARLGSDEFVVVQTPVADAQAAALARRIQSCLSEPFTIEEHTVTMGASVGIAIAPEHGERPDDLLRAADIALDHAKREGASSVLAFHADMDAQLR
ARVAIKRDLHQALADGQFVLHYQPVYDLRSGQVRCFEALLRWQHPDRGMISPAEFVPMAEETGLIVPIGAWVLREASRQAAAWPAA----VSVAVNLSPL
QFRDPALVDTVRQALGEAGLSPQRLQLEITESVLLQESQTNLSTLQALREVGVRIAMDDFGTGYSSLGYLRSFAFDKIKLDRSFVTDLHGGHEARAILHA
VASLGAAFELVTTAEGIETESQLAAVREEGYDEGQGYLFSPPVPAAQALQLL--------
>tr|K0HWY1|K0HWY1_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. KKS102 GN=C380_18770 PE=4 SV=1
--------------------------------------------------------------------WQEALTMLQEQRSALQATLASMSQGIFKTGPD
GRITVYNERVLELLNLPESLGDFGE--GY-SLVDRRGHDYV-----AQ-GAVAPAPALYWRTTRDGRTFEVRTTSLA----DG---SLVRTFADVSDYVR
VENELRESESLSDLSSDWYWEHDAEGRFVQLAGDLSV-NGIPLSDVMGRTRWEIGATDADWAAHRAVLA----AHQPFRELQRRRADGSMHWISVSGVPV
FDANGALRGYRGVGRDITERKQVESQIERLAFYDSLTGLPNRRLLVDRLQHATAAVARSGTQGALLFIDLDNFKDLNDTLGHDTGDQLLLQVAQRLKGCV
RESDTVARFGGDEFVVLVEGLSAAEAALVASHITTTLGKPYALGDASHHSTPSIGIALFGQQ-VSVDELLKHADLAMYQAKAAGRNTQRFFDPDMQAAVS
NRSALEADLRRGLQEKELVLYYQPVVDG-KGRLQGAEALVRWRHPRRGMVSPAEFIPLAEQTGLILPLGQWVLEAACAQLVAWSRSSLTQFFLSVNVSVR
QFRQPDFVEQVLGVLDATGANPERLKLELTESLLMADVEDVIARMEHLRRYGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQGFVRDLQTDPNDAAIVRT
ILALADSLDLAVVAEGVETTGQLEFLQRYGCKAFQGYLFGRPMPAEVLERAL--------
>tr|H0C0B7|H0C0B7_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. NO-1 GN=KYG_15540 PE=4 SV=1
--------------------------------------------------------------------WQEALTLLQEQRSALQVTLASMSQGIFKTGPD
GSIIVYNQRVLELLNLPESLGDFGE--GH-SLVDQRGYGYV-----AG-GAVAPAPDVYWRTTRDGRTFEVRTTELP----DG---SLVRTFADVSYYVR
VENELRESESLSDLSSDWYWEHDAEGRFVQLAGDLSV-NGIPLTSVMGHTRWEIGATEADWAAHRAVLQ----AHQPFREIQRQRPDGSMHWISVSGVPV
FDAQGALRGYRGVGRDITERKRVESQIERLAFYDALTGLPNRRLLVDRLQCATAAVARSGAQGALFFIDLDNFKDLNDTLGHDTGDQLLVQAAQRLAACV
RDVDTVARFGGDEFVVLVEGLSASEAAVVARHIAQALGKPYALGDTSHHSTPSIGIALFGDK-SSVDELLKHADLAMYEAKAAGRNTQRFFDPDMQAAVS
SRAALEAELRRSLHDNELMLHYQPVVDG-EGRLLGAEALVRWNHPQRGVVMPAEFIGLAEQTGLILPIGQWVLEAACAQLVAWSRSALTRFFLSVNVSVR
QFRQPDFVEQVLGALQASGANPEQLKLELTESLLLTDVEDVISRMEHLRRYGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDKSFVRDLQSDPNDAAIVRT
ILALAQSLDLAVVAEGVETAFQLEFLQRHGCQAFQGYLFGRPMAPELLERAL--------
>tr|J0TX76|J0TX76_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_07060 PE=4 SV=1
--------------------------------------------------------------------WHEALTLLQEQRQGLQVTLASMSQGIFRTGPD
GRITIYNQRVLELLNLPESLGDFGS--GY-NLVDHRGRDYI-----AR-SAVDPSPEVYWRTTRDGRTFEVRTTRLP----DG---GLVRTFTDVSDYVR
VENELRESEGLSDLSSDWYWEHDADGRFVQLAGDLSV-NGIPLSSVMGRTRWEIGAGDADWDAHRAVLA----AQQPFRELQRQRPDGSMHWISVSGVPV
FDGQGVLRGYRGVGRDITERKQAELQIERLAFFDALTGLPNRRLLMDRLQRATVAAGRSHAHGALLFIDLDNFKDLNDTLGHDTGDQLLVRVARRLLSCV
RESDTVARFGGDEFVVLLDGLHSSEAATIAQSILAALGKPYDMDGISHHSTPSIGIALFGQR-STPDELLKHADLAMYQAKAAGRNTQRFFDPDMQAAVS
MRAALEADLRRGLNQQELLLYCQPVVDA-SGKLLGAEALVRWNHPRRGLVLPGEFIPLAEQTGLILPLGQWVLEAACAQLVLWSRSALTPFFLSVNVSVR
QFRQPDFVTQVLGALQASGANPERLRFELTESLLLTDVEDSIARMEQLRRHGVGFSMDDFGTGYSSLSYLKRLPLDQLKIDQGFVRDLQTDPNDAAIVRT
ILALARSLDLSVVAEGVETPGQFEFLQRHGCQAFQGYLFARPMPAEMLERAL--------
>tr|A1WHK4|A1WHK4_VEREI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Verminephrobacter eiseniae (strain EF01-2) GN=Veis_1344 PE=4 SV
-----------------------------------------------------------------------MLALLQEQRAALQATLASISQGIFKTGPD
GRISVYNQRALDLLDLPESLGDFGP--DY-GLVGPLGQDYL-----AQ-GGRDSAPAIYWRTTRDGRTLEVRTNALA----DG---SQVRTFADVSDYLR
VENQLRDSESLSDLSSDWYWEHDAQGRFTQLAGDLSV-NGMPLSAVLGRTRWEIGATEADWAAHRAVLA----AQQPFRELQRRRADGSMHWISVSGVPV
QGADGTPRGYRGVGRDITGRKQAEGQIERLAFYDALTGLPNRRLLLDRLQHATVAVTRSNTQGALLFIDLDNFKSLNDTLGHDAGDHLLQQAAQRLKACV
REVDTVARFGGDEFVVLLAGLSAAEAAQVAKHIAASLGQPYALGGAVHHSTPSIGIALFGPQ-CRVDELLKQADLAMYQAKAAGRNTQRFFDPEMQAAAS
HRSALEADLRRGLQQRELVLHYQPMVDG-QGRLQGAEALVRWNHPQRGLMPPAEFTPLAEQTGLILPLGQWVLETACAQLVAWSRSALTAFSLSVNVSVR
QFRQADFVQQLLATLEASGANPERLTIELTESLLLNDVQDIIARMQQLRCHGLGFALDDFGTGYSSLSQLKRLPLDQIKIDRSFVRDLPADAGDGAIVRS
ILALAQSLGLAVVAEGVETRAQLEFLQHHGCQTFQGYHFGRPMPPEALAHRF--------
>tr|A0A0A1VCZ4|A0A0A1VCZ4_9BURK Uncharacterized protein OS=Acidovorax sp. MR-S7 GN=AVS7_01305 PE=4 SV=1
------------------------------------------------------------------------AEPLRQQIARMRTALASMSQGIFQTGPD
GRINVYNQRVLQLLDLPEQLGDFGT--TY-DLVDMRGRDYI-----AE-GAVRISPEVYWRKTRDGRTFEVRTKTLP----DG---GLVRTFADVSDYVR
VQSELQTSESLCDLSSDWYWEQDAQYRFTDFAGVSAH-KDARLESMLGRTCWDTPAREEDWAAHRRLLA----ARQPFRELQRVGANGQAYWMALSGVPI
IDASGVLRGYRGVGRNITERKRVEGEIERLAFYDMLTGLPNRRLFLDRLQRACVGLQRSQRHAALLFIDLDNFKDLNDTRGHDTGDQLLAQVAERLRACM
RASDTVARFGGDEFVVLVENLAGQDADKLARKIAGVLSQPYALGSPAHHSTPSIGLTLFGHP-AAPEELLKQADFAMYQAKAAGRNAVRFFDPGVLAAMS
ARSELETELRHGIARGDLRLHYQPVVDA-QGRMVGAEALARWQHPVRGMVSPAEFIPLAEQSGLILPLGRWVVESACAQLAAWARQAATQLVLSVNVSAR
QFRQPDFADQVLGALRASGASARLLRLELTESLLLTDTEEMIAKMEYLRAQGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDRGFVRDLLTDPNDAAIVRT
ILALAQSLDLGVVAEGVETTGQLDFLQRHGCQAFQGYLFGRPVPMEDLERRL--------
>tr|F0QCU2|F0QCU2_ACIAP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax avenae (strain ATCC 19860 / DSM 7227 / JCM 20985 / N
--------------------------------------------------------------------AS--PPGHAAPPEMLRTALDHMASGLLILGAD
RRVRFYNDRLPGILDLPRPLGDFGP--GF-ERVDERGRPYM-----ES-GDALPPPGVYWRKTPDGRMLEVFTAPLP----GG---EWLRTFSDVTPHML
LQSELRLSESLCDLSSDWYWEQDAEHRFVHVNQGIKG-LGISEDEVVGRTRWELGASAQDWIEHRRLLA----ARQPFRELQRTAADGRIYWVSVSGIPV
FSADGAFLGYRGVGRDITERKRVDAEIERLAFFDPLTGLPNRRLLTDRLHRAIGTAAQEHSHGALLFLDLDNFKDLNDTLGHDMGDRLLVQAAQRLLACV
GAGDTVSRFGGDEFVVLAEGLPGADAAVLANRITAALGRPYAVGGGYHHSTPSIGLALFGGGAAGVDDLLKHADLAMYQSKAAGRNTIRFFDPSMLQAVL
ARAALESELRHALESDELLLHYQPLVNG-DGSMLGAEALVRWRHPQRGLVMPGDFIPAAEQGGLIVPLGQWVLERACAQLVAWSRNAATQLVLAVNVSVR
QFRQPDFVDQLLQTLRRSGAQPRLLKIELTESLLMADVEEVIARMEQLRAHGVGFAIDDFGTGYSSLAYLKRLPLDQLKIDQSFVRDVLTDPNDAAIVRT
ILALARSLDLDVVAEGVETTGQLKFLQRHGCKAFQGHLFGRPAPAAVLERAL--------
>tr|A0A0D7KCG1|A0A0D7KCG1_9BURK Diguanylate cyclase OS=Acidovorax temperans GN=RP29_04235 PE=4 SV=1
--------------------------------------------------------------------VR-TSALLGEKTNALEATLASVSQGIGKVDAD
GKIRVFNQRYLELLELPREFGDFGQ--GF-ELVEADARAYVQAEYAEK-GRGQTMPDTYVRRTRNGRYLEVRTRTMP----DG---GLVRTFTDVTDYVG
TLEALRQSESLTHLSSDWYWEQDEQLRFVRLDGRSSHEAGIQDDSFYGRTRWELDNDDKLWREHRAQLQ----AHEVFHEIQRRKPSGEWMWVSVSGEPI
FDKQGQFAGYRGIGRDITAHKRAEAEIQRLAFYDELTGLPNRRLLMDRLERAVTQSARKGTHGALLFLDLDNFKGINDTLGHEWGDRLLTLVAQRITASV
RASDTVARLGGDEFVLVLQGLQPVEAELVAQKVLQELSRPYTLEDAVLYSTPSIGITLFRNQ-PSVHELLKRADLAMYQAKAQGRNTLCFFDPAMQAAAS
ARSALEGDIRLGIERNEFLLHYQPVVNA-AGHRMGVEALVRWHHPQRGMVSPGEFIPLAEQTGLILPLGQQVLRMACTQLAQWSQQPDTDWTVAVNVSAQ
EFRHPDFVKRVLDALRESGANAHQLKIELTESLLLQDVEDGIAKMRALREQGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFVRDVLTDPNDAAIACT
IVTLAQSLGLDVVAEGVETEGQREFLLRNGCHQFQGYLFGRPVPADQL------------
>tr|K9PVJ6|K9PVJ6_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Leptolyngbya sp. PCC 7376 GN=Lepto7376_0391 PE=4 SV=1
------------------------------------------------------------------------SHLLASVASQIRLSLELQPILDTTVEKL
QAFLGCDRVA--IWQFQSDHAVISVSDKVRS-QLGQRVRVVADIYQSLLEELQTRAKVLLPIIEGRKLWEATESCAPRQWHPEEVTLYQQAHGELIERRQ
TEIRLKESETLAATAPVGIYRTDAKGNCVYVNERWCRIAGIEAEKALGAGWMQGLHPSD-QEAILNEWQQSIREEPFNLEFQFKRPDGFATWVFAQAVAE
HDEDGQIIGYIGTITDISNFKQAQELILHHTLHDPLTNLPNRTLLMERLRFVLARMQEMDYRYALLFLDLDGFKVINDSLGYLIGDQLLLAIARKLEKHV
REVDFVARFGSDEFVILLEDIDKEDIIQIVEQILVDFKTPLFIGEYEIFTSVSIGIVIGTHEYHQAADVIRDADIAMHRAKSRGRNLYQLFDSAMHEQMM
YRLNLETSLRKAVKRKEFIVYYQPLVDILNRQLVGFEALVRWENPDHGMVSPADFVPIAEETGLVAQIDRYVFKAACHQLADWKSRDCFPLKMSINLSAQ
SLHRANLIEGIEKTLAETGLDGTDICLEVTESMVIDDIDQTIKLLNQLKARNIQISIDDFGTGYSSLSYLHRLPANNLKIDRSFIGFMEVGDRNYQIVQA
LITLSKQLDLTVVAEGIETKEQLQWLQDLECQLGQGYLFSKPLGCSEIEKSFLAMDVA--
>tr|U9W4X3|U9W4X3_9CYAN Response regulator receiver modulated diguanylate cyclase phosphodiesterase with pas pac sensor OS=Leptolyngbya sp. Heron Islan
-----------------------------------------------------------------------------VSEARFRAIFNHTFQFIGLLAPD
GRLLEANQTALNFGGL--------R-----------VI------AAQ----------EVDVLGADNQ--TIDFSLIPVVDDSGEVILIIPEGRDISDRKR
IEIDLAESRSLAAASPVGIFRTNQQGDCLYVNERWCEIAGISSEEALGPGWTVAIHSDD-RARVSQEWYQAAQANTFQSEYRFQTPAGTVTWVFGQTVAE
YDAEEALTGYVGTITDITERKHLERQLSWQATHDALTELYNRRYFEAELENVVQTTVQQNQHHVLCYLDLDQFKVVNDTSGHLAGDELLRQLARLLKRHI
RAADTMARLGGDEFGILLNQC-PDRAVNIAENLRQEIADYPFIWDQIFRVGVSIGLVVVDSTSTTATAAMSAADAACYAAKYRGRNRIQIYQKNDVELSQ
QRQHWSIVIRQALENNRFCLYRQKITQTLNPEGTFYEVLVRMLNDSGESIAPVEFIPAAERYSLMPMLDRWIIQTCLENLE----LGVEKILYSINLSGT
SLNDEQFLEFVTAQFAKFNVPPDHICFEITETAAIADFEQATSFIRALRRLGCCFALDDFGSGMSSFAYLKALPVDFLKIDGGFIRDITSDSTTEAIVES
IHRIGNVMGLQIIAESVENDAILTKMQTIGIDYVQGYAISRPSFWC--------------
>tr|K9EWR2|K9EWR2_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Leptolyngbya sp. PCC 7375 GN=Lepto7375DRAFT_3736 PE=4
-----------------------------------------------------------------------------VSESRFRAIFDHTFQFIGLLEPD
GTLIEANQAALDFVGL--------S-----------VI------SAQ----------EVDVIGGNNQ--TIDFSLSPVKNDAGEVILIIPEGRDISDRKR
IEIELEESQSLAAAAPVGIFRADRWGDCVYVNERWCKIAGLSLEAALGTGWAEAIHCDD-RTRTSQQWHHATQTGTFQAEYRLQTPAGSVTWVFGQAVPQ
YDNDGDYMGYVGTITDITEHKQLERQLSWQATHDTLTELFNRRYFEAELEDIVTTAVQQNQSHVLCYLDLDQFKVVNDTSGHLAGDELLRQLARLLKRHI
RAVDIIARLGGDEFGILLAQC-PDRAVNIAEDLRQAIADYPFIWEKIFRVGVSIGLVVIDSNSTDAIAVMSAADAACYAAKYRGRNRIQIYQKDNAELNQ
QRQHWSVVIRQALENDHFCLYRQKIAQTINPQGTFYEVLVRMIRDSGENISPGEFIPAAERYGLMPMLDRWIIRNCLANLE----LGIENVLYSINLSGM
SLNDEHFLEYVSAQFERFNVPPECICFEITETAAIADFECAISFIRALNRLGCRFALDDFGSGMSSFAYLKALPVDFLKIDGDFIQGVITDSTTEAIIES
IHRIGHVMGLQTIAESVENEAILTKMQTIGVDYVQGYGISYPSFWC--------------
>tr|B0C150|B0C150_ACAM1 Signal transduction protein containing an EAL domain, a PAS domain, a CBS domain pair and a GGDEF domain OS=Acaryochloris marin
------------------------------------------------------------------------AATLYFCQERFRVMFEQAVIGIAHVDLQ
GQVMLANQRFCDLLQRTPAQVTHTP-----------VLKTYLSEASQQLVDQGSYHQTLEFIHKNGT--VIDCSCNVVTDPASQEPYILMVQRDISDQVQ
ADTALRESEQMADCAPVLLWMSGVDKQCTFFNQQWLEFTGQTMAHELGKGWAEGIHPED-RQTSLDICKTAFDARPFCMEYRLRRHDGAYRWLIDMGTPR
FLPNGEFIGYIGSCVDITDRKTLEQQMTWHASHDSLTGLVNRYQFEQLLQKALQSAHRDQLQHVLCYLDLDQFKIVNDTCGHAAGDELLQQVAELFKHTI
RSTDIIARLGGDEFGLLLHQC-SERAQVIAEQLRQRLQTFRFNWQQAFSIGLSIGLVAINYDSHNLSSLISAADAACYAAKARGRNRIHVYQLDDLELVQ
QRGRWSRRIKQALEENRFRLYGQAIVPADPEQSECCEVLLRMVDEQDQVVSAATFIPAAERYNLMPEIDRWVISQFLVDHFNPPQKGDQPFPYMINLSGA
SIGDEQFLQFLQEQFQRYPHAAPQICFEITETAAISNLNQAITFINELKQLGCKFALDDFGSGLSSFAYLKTLPVDYLKIDGHFIEDMANDPATQAIVES
INHIGHVMGLQTIAESVGDLSTRKQLQSMGIDYVQGYGIALPCSLTYA------------
>tr|E4TYU9|E4TYU9_SULKY Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sulfuricurvum kujiense (strain ATCC BAA-921 / DSM 16994 / JCM 1
-----------------------------------------------------------------------------QNALKLRTLFEAL----------
--------------------------------------SDYEAIESPAIIQNGQDCFETVHKTKNGKLLV-----NVVSITFLDHPYMMAVYRDITEQKK
ADQTLAKQTTLVSTIPDLIWLKDTEGTYLACNPMFERLYNAKESEIIGKNDFDFVDP-ELAQFFRENDNAAMRLGSHHNEEFLQFADGSYAGTFTIKTPM
KDPSGKVIGILGVARDISERKKHEEQLEILANFDPLTGLANRGLLHAHLQNSIDKANRDKTQLALLMFDLDRFKDINDSYGHSAGDELLQMVSERFTSRL
REGDLIARLGGDEFAVVLENITREDAGRLAQEMLGTLAEAYRLSGALIHVGASAGIVLFPDHGSDAAILLQHADAALYKAKAEGRGVYHYYTDELTDSAR
QRIECETRLRRAILNQEFEVYYQPQVHIQTGRIVGAEALIRWNSPVKGLVSPAEFIPIAEEIGLIGEIGEWVLNETCRQGKIWLDMGHR-LTLAVNVSAH
QVRHQNVPHMVEEALKKSGYPADRLELELTESALMQREEETVEMLHSLRAHGIRLAIDDFGTGYSSLSYLKRFPIDVLKIDKSFVDDIPYERDDMAIVSA
IIAMGQALGFQVLAEGTERIEQIDFLREKGCTMYQGYFKSQPLRATEFEKLLH-------
>tr|K7S6Z6|K7S6Z6_9HELI PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Candidatus Sulfuricurvum sp. RIFRC-1 GN=B649_11360 PE=4 SV=1
-----------------------------------------------------------------------------KNALKLRKLFEAL----------
--------------------------------------PDYCTTETPAIEREGKDSFVTQHRTKDGSVIV-----NVIAIDLGGVPHMIAVFRDITEQKR
IERHLAHQSTLLDNIPDLIFSKDLDGKYLACNTMFERFFGEKESAIIGKTDFDFVDA-ALAQFFRDNDHAAIRGGPRNNEEYLMFADKSYEGQFVTKVPM
KDASRNVIGMLGIARDITERKRYEAQLETLANYDPLTGLANRALLMSHLQNSIVQAKRHTAQIALLMFDLDRFKDINDSYGHHAGDELLQVVAERFSSRL
REGDIISRLGGDEFAVVLEHLAHEDAGRLAEEMIEALGAEYKLSGASIHIGSSVGIVLFPDHGEDASELLQHADAALYKAKAEGRGTYHYYTDELTDSAR
KRIECETRLRRAVMNQEFEVYYQPQVHIATGRIVGAEALIRWNCPVRGLVSPTLFIPIAEETGLIGEIGEWVLNETCRQGKIWLDQGHR-LTLAVNLSAH
QVRHQNIPAMVEDALKKSGYPADRLELELTESALMQREEEAVAMLHTLRAHGIRLAIDDFGTGYSSLSYLKRFPIDVLKIDKSFVDDIPFESDDMAIVTA
IIAMGQALGFQILAEGTERIEQIEFLREKGCTMYQGYFKSPPVPAAEFAKLLA-------
>tr|Q2BIR8|Q2BIR8_NEPCE Uncharacterized protein OS=Neptuniibacter caesariensis GN=MED92_00325 PE=4 SV=1
------------------------------------------------------------------------TQKLIENEQRFRMLFDESPISMAYVSFS
GEVLSLNKRFTEVFGYTKDD-----EDWFIK-AHPQQEGDLDAIETPLIKHQGGQRFLTKHRRKNGDIYV-----NATYWSGGGGR-FFVFLRDVTERIN
YEDRLG-------STNEGVMITDVDGQIQMVNEAFCSLTGYGKDEVIGQPAKILQSGRHSAEFYHEMWESINDVGSWQGEIWNRRKDGTTYPEWLSISAV
KDDDNRVNHYVGVFSDISQLKESEQKLNHLAHHDMLTGLPNRLMLQTRLDQALAQARRKNTSLALLLLDLDRFKDVNDSFGHSAGDELLKQVASILKEGL
REVDLVCRMGGDEFAILLEDIQHEDAGKVASKVTSLLAKSWNISGYEVAIGGSVGISLFPEQSGDSQALLQHADAALYRAKSEGRGRFHYFTEELTRDAR
KRLDLEARLIKGIARNELEVYYQPQIHIATGKLVGAEALVRWNDPEHGLIGPNEFIPLAEQTGLINDIGLLVLKQGCSQLKAWLDAGCEPFALAVNLSAV
QLRHSDIRPVIANVLEETGLEAKYLELEITESALMEREQESIQLLDSLRSLGVRIAIDDFGTGYSSLAYLKKFPLDVLKIDKSFVDDIPADKDDMVIAAT
IVAMGHSLGLQVLAEGVETEEQLAFLRSKNCHYYQGYLRSKPVPADQFANFLTYHN----
>tr|U1KQW8|U1KQW8_9GAMM Sensory box/GGDEF family protein OS=Pseudoalteromonas spongiae UST010723-006 GN=PSPO_11186 PE=4 SV=1
----------------------------------------------------ANSANPIGYIVKPYNLRFRYEDEITSSEARLKLAIEAANLNVWEYNPE
AEHLVFTGTEQKYFGHLSPLPLN---EFI-SMVHEQDKWKVESLLKD--GQKSNQKIRVQSP-LSDEQYWFEVYTSDIKL--QGGDTPIGAMKDVTETET
YIRELKVSKSVFSHIADGILVLNKNCEITKANPAFCKLIGYPLSQLINKKYNIVKRERAEDINQ-QPWEDLC------SRREETFKTESGELFYALVNGK
LISQDQSDELVMIVTDISELKMAERKLQYQAYRDELTGMYNRTYMNRAFANPQEF--FDSGKFTLMFIDLDSFKLINDTYGHSYGDVILAEFAWRLKHIF
RSSDIMIRHGGDEFVLMLDGQLTNDVSKIANSINKAISEPFKCKDVSISLTCSIGIAQWDDTISDTSDLMKRADIAMYAAKNGGKNDFRFYQEDMGSSAQ
YQLFLEQGLKLAIENELLELWLQPIFD-YKGEISSAEGLCRWRDKATGFISPNDFIPIAESSWLIFPLGELMLKKVCDAIEHLSNAGFTDIKLGLNLSAK
QLSHPSLPAKFEEIINCKQVSPNNITLEITET-ALTDT-PAVKNIERLREIGFSIALDDFGRGYSSLELLQQFDLDILKIDRVFIEGIPDDRKAQKVCEH
MVNLSKSLGYKVVVEGIESAKQSEYFAQDPAIHQQGFYHAKPMPLSLFLSLLGGQ-----
>tr|A0A080LX31|A0A080LX31_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-91 GN=gmr_12 PE=4 SV=1
----------------------------------------------------ALASQPFGYLVKPWDARREVEVAVESSELRLKLAMEAASLGVFEWLPQ
FNRMRGDGHL-GALFGDRPVPL-----FL-VRVDDDDRDRVIASLSEALTCGSAVRIEFRTARNDGPHFLEANVKAYPGT--NAQRRVLGVLQDVSERRR
TEDRLRQSGVVFHSAAAAIAIVDVERRVAAVNAAFTRITGYSEAEAIGLDLLLLRVQRGKQVGSAGFFGQAADGF-WEGQVFCQRRNGESFPSWQSVSVV
--PAGKADNFVISFSDVSDIHLANEKLKHLAHHDSLTGLPNRLLFNDRFEQAIKLARRQKNRCLLLFLDLDNFKVLNDTLGHDVGDELLRVVARRLRDAL
RGNDTVARLGGDEFVLVAGSA-SDYGAELARKLLDTLRAPVSLVGEEITVSVSIGIAVFPDDGRDVPLLMRAADIAMYSAKAAGRDRFRFYSLDMAERSN
ERLQIEQGLRRAIEMDDLQLHYQPQVSLAERRVIGVEALVRWPHPQLGMMPPARFIPIAEESGVIGSLGRWVLERACREVLGLHDDNGRQLRLAVNVSAR
EFTGDDFIATVSDTLVRTGFPATALELEITES-TLQVIGRSVEILRELKALGIAISIDDFGTGYSSLSVLRDLPIDRIKIDRSFIHDVPENPQGIAIVEA
IVALADSLRMDIIAEGIERPEQAASLLRLGCSGGQGDLFSRPIANPELVRLLASA-----
>tr|F7NTB4|F7NTB4_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Rheinheimera sp. A13L GN=Rhein_1016 PE=4 SV=1
----------------------------------------------------AEKSFPHGYLIKPFDRRHQAELKVRISEQRLQQTLNAAKMSHWQLNLT
TDQLDIDYS----FYDNLQQPDL---KSI-LAVDEH--QRL----SQFFARKTDFNAVFTAAR-KKPLQYLELFGHFQSS--QDQHLISGILRDVTDKQK
EELQLRQANTVFKTTSEAILVLDDAGEVISVNPAFSLVTGYSEADVRGMQPNFLYPKQQTSP----VSVRLSSSH-WSGEVECKRKDGSLFPAWQHLCKV
RAPQGTISHYVVMFSDISALRRAEEHLATLAFSDHLTGLGNRVKLEKMLRTELVRANRNQSMLGILYLDLDGFKLVNDTLGHHAGDLLLQEVAKRISDLT
RAGDVATRVGGDEFVLVVPDIHHSDCLRVAEKILHIIGQDISLQDNIVNVSASIGIACYPDDATSYEELLKCADLAMFAAKDEGRNRFTFFNPLMAEKTR
QRVQIEKDLKTALCADELIMYYQPIVRISDQELRGFEALIRWDHPTMGFIPPDRFIKVAEQSNLINEVGDWVLQQVFKDVAELIQRYGKDITVSINLSVR
QLEDQQLAAKINQLSSEHHVPLSLIYFEITET-ALSQSHSLLNTLDQLRCLGARISVDDFGTGYSSLSRLRELPIDCLKIDRAFVISLGKDRSSAEIVRA
ICALGKALELIIIAEGVETQAQYQILKEIGCDKAQGYLFGRPGPLG--------------
>tr|K9DMH7|K9DMH7_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia timonae CCUG 45783 GN=HMPREF9710_04815 PE=4 SV=1
----------------------------------------------------AAGAMPYGYLTKPFQGKAEVERALRDKERWLSSVLHGVGDAVIA----
---LDADGLV-GLAN-PAAESLA---AEV-VRLEDDTGGTVRLAHHDCTARS-GAA-MLVTGAQRIPVDYSA----GPIC--DERMGTAIVLHDERERVA
AELRLAHSEQRFDNAPLGLALVDRDNRYARVNRAMCRLLGAPAEALVGAVQAFGDSGDNAIE--REYQQDLAGRS-DAVQYERRYRPRDGRTVWALVSAT
LLPDHEPQHFLIQVNDVTERKRAEEELAHLAHHDALTGVANRAMLSEQVERELAVARRRGSRLAVVFIDLDYFKHINDTYGHETGDVVLKELASRLAHSV
RAIDIVGRLGGDEFVVVLSEVSDRDVIALTDKLRLECGRPLHFNGHEVRLAVSMGVSLFPEDARDFRTLLRFADSALYQAKGEGRNNVQFYRPELTARME
MRVRLGAGLRTALERGELEMFYQPIVTLADGRPAAAEALLRWHHPELGLLMPDLFLPMLEESSMAEEIGAWTIREACRQAARWNADGGAGLRIGVNVTAS
QFKSGRLVPVVEAALRATGLAPGRLCIEITEQSQLADTGQTRATLAALKDLGVLVAIDDFGTGYSSLGYISRLKPALLHKPR-----LGQRGS-------
------------------------------------------------------------
>tr|F2G8S8|F2G8S8_ALTMD Uncharacterized protein OS=Alteromonas macleodii (strain DSM 17117 / Deep ecotype) GN=MADE_1013270 PE=4 SV=1
----------------------------------------------------ALAISPYGYLVKPYGMRKKTEKALASSNRRFAMASKIAKLGVLEVDTS
AQSVVIESVE-NLFDFPRKMPVS---KFL-ALFPEEKKSELKQAIHLKSNYLTTLQLK---V-DGQPTKWFQVVLSDVGW--GDDYVQIGAIQDISILQS
TQSNLSVADKIVSEIKEGVLVCDAVGLIIKANQSLCDMLGTKVKHLISTHISVFPKARKHDPRP-DYLI--D------GLRTELTIVSEGRRFHLTMSVT
SFEDDGETNFVAILTDVSELKSSESQLKYLAFTDALTGAGNRNLLNSIVETYNES----CEPCSIIFIDIDEFKLINDTHGHEVGDEILRACASRFKAAL
RGDDTVIRFGGDEFVVVTSTTCHKLLKKMTSRLSLSLKKIFKTTSGDFQITASIGLASSTESMS-PTELLKNADIAMFSAKQGGKNGVVTFSDDLSKNIE
YRLFIQQGLKSAIQNKQITAYFQPIID-SKGEVLAVEALARWHIPSHGPISPDKFIPIAERTKHIHDIGLLMLDEVCFALKALSGWGFLNVKFNLNMSAV
QLQNDGVVELFAERFAFHNIDPGRIVIEITES-TLQSA-KARDVLIKIKALGVIVSIDDFGTGFSCISELADETYDAIKIDRSLLPGFPLQSEQELIIEN
VVSMCVKLGMPCTLEGLETIEQVSFAKKIGAKAMQGYYFTRPVNLVGLMEYLQAE-----
>tr|M7PQX3|M7PQX3_9GAMM PAS/PAC and GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Methylophaga lonarensis MPL GN=MPL1_08157 PE=4 SV=1
----------------------------------------------------NDSAEETLYVIKFYSELEQYEQQKSAELGKLKSALETENDAIWHYSVE
DRTVRLSPHFQYGIDEL-----T---QWM-MCIHPEDRQKLAEALEQHILDHRRFSCEYRA-LADGEYRWLLSRGTIVET--DADELITGIVSDVTHVRN
TYSMLEQTEANLNSMADGVFVA-QNHRFVFANQAMTNIIGMEFYEFIDSPFQVISAEFLPIWNE-RYVKRGGDKT-IPSRYELKRRADIVGEIWVELIAS
SVTFQSEKAVMGIVRDISDRKAAEALIWNQANYDFLTKLPNRKLLEDNLKALLSTARSSGNRLAIMLLDLDDFKGVNDTEGHAFGDKLLCTVADRLVEAV
PDSECIARFGGDEFVIVLSLDSDAQIEQAAQNVLSYLSKPIQIELNTHYVSASLGITVFPRDARSIYHLLRNADLAMYAAKSAGRNCYRHFCPEMQVIND
KRMELIRDMQHALVGEEFYLVYQPIVSLKTGALIKAEALLRWQHPAKGQMSPASFIPTAEESGLILPIGEWVFEEALRMAAKWRYLSHKSFQIGVNISPK
QLSNNDTYRDFIEVIKSQEYEGNMLCVEITEGMLLEPNDKAIARLKGFRELGVKVALDDFGTGYSSLSYLKKFDIDLLKIDRSFVKNLSEGSDELVLCQA
IITMAHTLNIEVIAEGIETEEQMQLLKDAGCDYGQGYFISYPLSAEEMEQRILNE-----
>tr|A0A0A0C3W2|A0A0A0C3W2_9CELL Diguanylate cyclase OS=Actinotalea fermentans ATCC 43279 = JCM 9966 = DSM 3133 GN=N867_10465 PE=4 SV=1
------------------------------------------------------------------------AEASATVERRLAVVLSAGRDGVVVHAAS
GAVLVANEAAAATFDVPVAQLVGRR---VGELPVREQG--QEVTPASQGADAPPFVVG--ALPHTGPVRWVQASTRLVGAGD---GDLLTVLADVTGPRE
VRAALAQSELAMENAPIGMGLADPQWRLQEVNAALAALFAVEPAVLIGHDLSALSHPDDRGVERAQVQRLLAGEG-ERFEKRYLRPDGQVVWVVLDVVLV
RAADGAPAQFVVQMRDITESRLQSEALAHRAMHDPLTGLANRSLMQDVLQRACEPPDAP-GRIAVLAIDLDEFKQINDRYGHAAGDDVLIHVAGVLRGAT
AGRGLVARQGGDEFAIIVTGDDARIAFEIAGSIHKGLVNPVRTHRRQLPIRASVGVAVAEPAIAGAMGMLAAADAALYRAKGGGRSRTEVYDRSMTVTAG
AKHGAAAELVHAIETGELVLHYQPTVALATGQVVGYEALVRWQHPERGLLLPGSFLPTAVEGGLAVALGTNVVWQAASYLARTADTGR---WVSVNVSAD
QLGNGELAAQVLMALSRHRVGPGRLVIELTEAGLVDGESRIRHELAELREAGVPVLLDDFGTGIAPLSYLRDLPVDGVKLDMSFTAGIPEDPAAQRVSRA
LGALARELEMITIAEGVETTEQAQFLHACGWEYGQGWLFGAGESERVQA-----------
>tr|A0A0A0BYC4|A0A0A0BYC4_9CELL Diguanylate cyclase OS=Cellulomonas carbonis T26 GN=N868_01950 PE=4 SV=1
------------------------------------------------------------------------DARIADLERHLRAVLDGTRDAVLVHADD
GGVIAAGAAAAALLDVPVEQVLGVP---VAELPVADDG--SRVDPATVHASRPPTVVG--AVPATGPVRWVQVSTEAVSTPDG-RRELVTSFSDQTGPRE
IRAALARSEAAMENAPIGMALLDPRWRLEQVNAALAQLLGTTPEALRGRDLSALSHPEDRATERSAVHRLLSGEA-QRFEKRYLRTDGQTVWAVLDVVLV
RTEHGAPETFVAQVRDVTEARLQAEMLAHRAMHDPLTGLANRAHMHEVLTRALDHPDAS-GRVALLLVDLDEFKQINDRFGHPTGDEVLVHVGGVLRAAT
AGRGTVARLGGDEFVVVVEDPDARVAFEIAGSIHTALRNPIRTQRRRLPVGASVGVAVADAGLGGAPAVLAAADTALYRAKAAGKHRTEVWEPSMGSSAG
TRHGAAAELQAAIDAGQLLLHYQPTVDLSTGDVVGHEALVRWQHPERGLLLPGAFLATVDETGLGAALGATVIRQAVQYLARTADLGR---WVSVNVSAR
HLGDGEFVRMVVEEVRAHGIAQGRLVVELVESELGEPGSRTRHDIDELRAAGVPVLLDDFGTGAAPLAYLRDLPVDGVKLDMSYAAGIPDDPAATRVILG
LGAMAQHMDMVTIAAGIETAAQAQLLQRSGWRYGQGWFFGAGQSEPVQQ-----------
>tr|A0A0A0BWN3|A0A0A0BWN3_9CELL Uncharacterized protein OS=Cellulomonas bogoriensis 69B4 = DSM 16987 GN=N869_00240 PE=4 SV=1
------------------------------------------------------------------------RVTAAQARARLEAVLSAGREGLVVHSPA
GVVLEVNAAAAAAMGVSRSEVVGRR---LTDLPVTDDG--EQVAVAAPPGDLGAYSVG--LVQRGGAPHWVQPATSELADEQG-TPQLVTTFTDMTGPRE
VRAALARSEAAMENAPIGMALMDPQWCLEEVNPAFAVLLGTVPEALVGRDLSSFSHPEDRAAERRAVGRLLSGHD-ERFDKRYLRADGSTVWVSLDVVLV
RCPDGRPDHFVTQVTDVTELRTQAEMLAHRAAHDPLTGLANRLLMQAVLQKAVELPDAV-GRVAVIVVDLDEFKQINDRYGHAAGDAVLTHVAGVLRAAT
GSRGTVARLGGDEFVVVIHEGDARAGFEVAAGIHRGLRTPVRVERTRLQVRASVGVAVADHDLQGPMALLAAADAAVYRAKAGGRSRTEVYDASMAEPDG
APEGSGTELGGAIEHGQLVLHYQPVVELASGRVVGHEALVRWQHPVHGLLMPGEFLDAAGQAGLGGALGSAVVRQAVAHLVRGAT-PG---WVSVNLSAQ
QLSDPDLVEGVLAEVGRHGIEPGRLVVELTEAGLE-PDGPVRHGLTRLRAAGVPVLLDDFGTGVWPLSYLRDMPVDGVKLDMSFTAGIPADPAAEQVSRA
LAALAQQMELATVAEGVETEAQALVLQEAGWVHGQGWWFGEGRSEPVTG-----------
>tr|F4H758|F4H758_CELFA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBR
------------------------------------------------------------------------LELSRQLRQRYDALQSVTKEGVLVQSLS
GRVLDMSERAAAILGVDAESATGRP---VTDLPLVEQG--LSMNPAAGPSGGEPELVGVA--DPEGHVRMVQVASQLVPAGDGENPAVLTTLVDVTGRRE
VEAALSRSEVAMENAPIGMALVDLDWRIVEANAAFAELLGTRVDALRGYPMADLAEPEGRAAERVEVDRLLEGGL-PRFEQQYVRADGLTVWVVLDAALV
RSASGSPDHFVVQVRDSTESRLQAEMLTHRAMHDPLTGLANRTLMQEVLQSVLEQPGVV-DRVAVIACDLDGFKQVNDRYGHAAGDELLVHVAAVLRAAT
ARRGTVARLGGDEFVVVVQDADGRAVFEIAAAIHAGLVEPARIARRRVQVAASIGIALADPETGGAPALLAAADAALYRAKGAGRGRTEVYDSSMGVATT
S--SLHRELTDAIATRQLVVHYQPIVDLADMRVVGYEALVRWQHPHRGLLLPGAFLPLVQEAGMSVPLAQFVATEVVEFVSQTTDRTR---WVSINVSAD
QLGDGEFATTLLGEISRRRVAAGRIVVELTESSLVASGTRIRHELTQLSAAGVPILLDDFGTGVSPLSYLRDLPVAGVKLDMSFTSGIPDDPTAGKVARA
LGALARELAMVTIAEGIEHDEQARYLHRNGWRYGQGWLFGGAQPGDVSR-----------
>tr|F7ZZR4|F7ZZR4_CELGA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cellvibrio gilvus (strain ATCC 13127 / NRRL B-14078) GN=Celgi_2
------------------------------------------------------------------------LDLSRELRHRYDALQAVTKEGVLVVSLG
GSVLDISERAAAILGVEHDASVGRH---LTDLPVVEQG--LSMNPAATG-YVDSQLVGVPGAPGGGQARMVQVASQLVAAADGDAPAVLTTLVDVTGSRQ
VEAALSRSEVAMENAPIGMALVDLDWHVVEANAALAELLGTTVEALRGYPMEALGTPESRASERLEVDRLLGGGQ-HRFEKRYQRADDHLVWVVLDAALV
RTASGEPDHFVVQVRDSTESRLQAEMLTHRAMHDPLTGLANRTLLQEVLQSVLEQPGVV-DRVAVLACDLDGFKEINDRYGHAAGDEVLVHVAGVLRAAT
ARRGTVARLGGDEFVVVVQDIDGKAVFEVAAAIHAGLAEPVRVARRRLPVAASIGIALAEPDTGGAPTLLAAADAALYKAKAAGRGRTEVYDQSMAKSSS
V--DLLRELSEALDADELVVHYQPIVDLADTRVVGYEALVRWQHPYRGLLLPAAFLPLAQEAGLAVPLGQFVATKVAEFVASSPDRTT---WVSVNVSAD
QLGDGEFATTLLAEISRHRLMAGRIVVELTESSLVASGTRIRHELTQLSAAGVPILLDDFGTGVSPLSYLRDLPVAGVKLDMSFTSGIPDDPTAGKVVRA
LGALARELAMVTIAEGIEHAEQAEYLHRNGWRYGQGWLYGGAQPASATL-----------
>tr|D5UD96|D5UD96_CELFN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cellulomonas flavigena (strain ATCC 482 / DSM 20109 / NCIB 8073
------------------------------------------------------------------------VRVARQLHKRYDALQLVTSEGVVVQSRD
GTVLDLSERAAQILGVTRESVVGAP---VGRMPVVDRG--LAVNPGLDTE---RTTVVTLVPPGPGRPSVVQVTSRVMPPDEDGETSVLTTVVDITARHD
VEVALSRSEVAMENAPIGMALVDLQWRISEANVALAELLGTHASALRGYRIDELSAPEDRAAQRMEMDKLLGGGQ-QRFEMRCRRADDQLVWVVLDAALV
RAGDGAPDHFVVQVRDATESKMQAEMLTHRAMHDPLTGLANRTLLQEVLQTALAQPGAV-DRIAVLACDLDGFKGINDRYGHAAGDDILVHVAGVLRAAS
AGSGTVARLGGDEFVVVVQDVHAKAVFEVANEIHSGLAEPVRVGRRRLGVAASVGIALAEPHLAGAPTLLAAADAALYRAKQSGRGRTEVYDTSMELAAP
S--NVHRELLHAITTGEIVVHYQPIVDLSDSRVVGYEALVRWQHPHRGLLLPGAFLPQVQEAGVSVMLGQLVASRVVEFLATNAHDGR---WVSVNVSAD
QLGDSELATRLLQDLSRHRVTAGRLVLELTESSLVASGTRIRHELTQLSAAGVPILLDDFGTGVSPLSYLRDLPVAGVKLDMSFTSGIPHDPTAGKVVRA
LGALARELAMVTIAEGIENEEQADFLRRNGWRYGQGWLYGGALPME--------------
>tr|A0A086DXN9|A0A086DXN9_9MICO Uncharacterized protein OS=Cryobacterium sp. MLB-32 GN=JF66_13035 PE=4 SV=1
------------------------------------------------------------------------VTAARRAFVAARSMLETSLDSLVAISPE
GLITDANEATVKAIGIPRVELIGTA---FSEYFTEPDK--ADEIYRSMGPL----T----LRHRDGLTE-VLYNASVYRDASGNVLAVFAAARDVTALRA
FEAARS----MIESSLDSLVAISPEGLITDANEATVQATGIPRVELIGTAFSECFTEPQKA-E--AIYQLVFEKG-MAVPLTMRHRDGTLMEVLYNASVY
RDVDGNVLGVFAAARDVTGVRQAQEALIYQAFHDPLTGLHNRAWILDILDADLLAAKRVGHAVGALFVDLDHFKTVNDSLGHAAGDEVLTTVAHRIVAAL
RPGDRVGRIGGDEFVIVIQDVEHQDVLRCAERVSASISADIEVHGHRIMPTVSIGIATSTPMS-SSDSLLSDADSALFRAKASGRARWHFFDSAMNEQAV
ARRTLEEDLREGIARSEFFMYYQPIVALTDGRVVGHEALVRWSHPSRGLLHPEDFLEVAAATGLIKDIGAQVLRQVCALLAERPDLPG---PISVNVSAV
ELAAPGWLASVQANLTNYDVDPARIVIDVTETAALSLTESARDALASLRSAGAGIHLDDFGTGSSSLSVLRDLPVTGVKLDVRLVQDLTEKSNANTIAQG
VSGLVKGLSLTGIAEGIETQMQADILRAQGWECGQGYLFGRPASHP--------------
>tr|A0A085EYB7|A0A085EYB7_9BURK Diguanylate cyclase (GGDEF) domain-containing protein OS=Massilia sp. LC238 GN=FG94_03963 PE=4 SV=1
------------------------------------------------------------------------RQAFVTAIEL------APAVAVHSRDGA
GIVRFWNHACAQLFGIPASHALGKP---FRELVSHQRE--F-----DIWEA--PAPRDWRVET-AARRLWLHSNHFVKRDGHT-Q-QVFCMEVDITAR-Q
VEDNLSQAAA-----HEAIIV--MDAEYRVVNQAFTAITGFDAADIIGSTIASLPWGEDKDK--------EDGGG-GGGDTIWSQLDGNDRWQWVALTTI
RDPHGAASSYMATLSDISERKRAEAQVRHQAEHDTLTGLPNRALFLDRMHQALATWRR-QDSFAVLFLDLDRFKAINDNNGHQTGDAVLREVAARLRGCV
RRVDTISRLGGDEFVVLLADIGGDQAAHVANAVMGAVSRPFEVAGQQLTLSASIGIAICPTDGGDVDTLMHHADVAMYHAKQNGRSSFRFFSPEMNARVF
ERGELEKRLRQALERGEFVLEYQPELDVGSGKVIGMEALIRWRHPERGLLLPHEFLPVAEECGLIVPIGEWVLVEACTQARSWRDAGHV-VTVAVNLSDI
QFLHGRLLEKVDAALAQSGLAPAWLDLEITEGAIMRGDHVLDDTVKSLRERGVQLTIDRFGTGLSSLSSLRRFPLSKLKIDRSFVSDIEHDPADAALIPA
IIAVARSLRLRVVAEGVETEEQLRFLRQHGCDEYQGFYAAGASARPDFN-----------
>tr|Q9RX49|Q9RX49_DEIRA Sensory box/GGDEF family protein OS=Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 
------------------------------------------------------------------------AQALLDKLSL------PVL--VL--DRQ
GTVIHASEACGALG-W-SHDLRGRP---LAELLSSDLR--L-----SVWRL--HQ-VPLSLRH-TERLQLAEASLLLHAASGESTAAYVAMSITTTELHQ
SDDNARTDRSLLAALPASLAVLGPDQRYRFTDAEYVAERGFPPELAT-------ERGRHMDE--------AARER-KTVEERMLRPDGEPVYQGVDVTEL
RRTQEALRELNAQLEETAELEALSRQLQHDALHDSLTGLPNRALFSDRLSQAIARSKLPGPQYAVLFLDVDRFKGINDTLGHPTGDAMLVEMARRLRACL
RATDTVARLGGDEFTILLEPLQSEQAAQVAARIQDALRRPMQMPAHQVTMSASLGIVHSQPDYDSAMAVLRDADIAMYRAKDGGRAKYRVFTPEMREHIL
HVNRMEHELRRALAADELRVRYQPVLDLDRGRIEGFEALVRWQHPERGLLGPDDFTPIAEESGLLPDIDRWVLARACRELVQWQRLYPHDLHLSVNFCSQ
HLAAPDVHERVKELLQRTGFDPGRLNLEITESSLLSQTGDVQRNMERLRQLGVRLHLDDFGTGYSSLSYLQLYPIDVLKIDRSFVQGMLDNDSNAELVRT
IVAMAKNLNLKVVAEGIEDPRQLAALRGLGCDAGQGFLFSPALDVHAAR-----------
>tr|W0DPM5|W0DPM5_9GAMM Diguanylate cyclase OS=Thioalkalivibrio thiocyanoxidans ARh 4 GN=THITH_13905 PE=4 SV=1
------------------------------------------------------------------------RQLLAASESRQRAVFAALGEGVYGTNNS
LDCTFMNPAALKMLGFTQEEVIGRD---PHTLFHYDGE--PSDAREATVRT--RHEEGWFLRK-DGTGFPAEIIVTMVEGGHV-TGAVVAFN-DISER-A
AEAQLRQLSLAVDQSPESIVITDLDGRIEY-NQACVNKSGYSREELLGANPRVFQSGRT-----------------PPEGMMWDAVSSGRIWR-ATLAPV
RDPSGRISHFLALKQDISELKHAEAEIHRLANYDRLTELPNRSLLMDRLAQTLASSSRHPQRSALILCNIDRFKILNEARGQASGDLLLKAVGQRLDALV
RESDTVARLGADEFAILLQNLDPQGAFSVAEKIHLALRHPFTLDRDVVNVTASIGITLSPEDADTPQEILRRADTALHKAKHAGGNQSAFFEAGMGQIAQ
LRFHLERELRLGIPAGQLRLFLQPQVNTQR-EIVGFEALVRWQHPSRGLLPPGMFIPVAEESDLIVDLGVWVLARTCELMAHEQARGRP-FRAAVNVSPK
HFRQPQFVPWLRDLITGQGVDASNLTLEVTEGLMIENVEDVVAKMSALQPLGIHFSVDDFGTGYSSLAYLKRLPIHELKIDQGFIQDAPTDPDDAALVDT
ILNIARNLGLEVVAEGVETAEQAAFLNDRATILHQGHFYGRPEPAEAWL-----------
>tr|M1T2D1|M1T2D1_9PROT Diguanylate cyclase OS=beta proteobacterium CB GN=D521_0628 PE=4 SV=1
-----------------------------------------------LVLLPMATVLVCLLMQSQQKKII-AQNEADKALSRLNAISQAIPDLLIVLDKN
GKYLEVFSANQDLMVMPREAVIGKT--LH-DIFPKDQADFFLTWIRSVIADKDTKTIEYEVNTPAGKLDFEAR---------------------------
------------------------------------------------------------------------------------------------ARHL
DSPENGQESVVLLTRDISNRRILETQIHSLAYFDPLTNLPNRRHLMEHLEAIEKFNKEGKNFGALLHIDLDDFKYINEVHGHATGDQILRDLVLRLQEAV
QAKHYLARIGGDAFAILIQDLHGCLAKDFADQILNRMREPFIVGGNQISLSGSVGIVMLGSN-YPLHQLMVWAELALYAAKDEGKDTSRFFDPILQESLT
QRMKLENEIRVALITNQLKLVYQPQVNAR-GQIIGYEALIRWNHPEKGMLSPVEFLPVAEQAGLMSDIDRWVFHKVCKDLKELVQKSGPSLTISINIGGS
LLGQADLFEQLSNIVNNEGVDPNRIQIEVTETTLVKNLERSKAQMLALKTIGFKFSLDDFGTGYSSFNYLRQFPIDEVKIDQSFVHGLPEDHESLAIIKS
VVALAPTFGFTVIAEGIENMEQEQSLIDNGCTHFQGYFYSKPQPLEMLF-----------
>tr|Q2BHU8|Q2BHU8_NEPCE PAS:GGDEF protein OS=Neptuniibacter caesariensis GN=MED92_00805 PE=4 SV=1
-----------------------------------------------IVIFPLATVLLGGLLSQQISRKK-AEATSNHARHRLEATFSAIPDLLFEMDIE
GRYLACHASDPDDLVAKPEELIGKS--VF-DFIPLDEAQIIVEAIREADLKGISKGRQVTLQVGRGLREFELS---------------------------
------------------------------------------------------------------------------------------------VSRK
HDDESSEHHFIVLSRDITERKQDEADIHQLAFYDSLTGLPNRRSLQERLDSALSSCRHTRQLGAVFFIDLDNFKNLNDTAGHDQGDKLLVEVANRLNSCV
RNADMVARLGGDEFIVILENLGVEQVKDIVAKVILTIQAPLTIGTQAYHPTCSIGIALFSEKD-FSDEVMKRSDMAMYQAKSSGKNTYRFFDPVAEEALC
SLARMDADLRFALSNQQLELHYQPQYRC--QTLIGAEALLRWKHPDRGMVSPAEFIPLAEDTGLILPIGEWVIRQACKQLQQWQERPEAELFIAVNVSAR
QFCQDNFVESVRQLLNTYGVSAEKLKLELTESLVLMDVEDTIQKMQALRSYGIRFALDDFGTGYSSLSHLKRLPLDQIKIDRSFIRDVPEDQDDSEIVQA
IIAMGQNLGLNVLAEGVETDEQLAFLTELDCLDIQGFLLGRPSSIDKFE-----------
>tr|H0PZH6|H0PZH6_9RHOO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Azoarcus sp. KH32C GN=AZKH_2198 PE=4 SV=1
-----------------------------------------------LFVAITALLLFGLLGRLVGQIQD-SHREKRRALQLLAAISDSSADAIFAKDTQ
GRYLLFNRAASEFIGKSSAEVLGKD--DR-EIFPPEQAERLMAFDRRVLAENRVISHESTLQTADGKRVFLAT---------------------------
------------------------------------------------------------------------------------------------KGVL
RDGDSDVIGVFGISRDVTDRKQAEELIHNLSFYDALTGFPNRRLLLDRLKQTVLSGKRKRHHGAILFIDLDDFRALNDTRGHEVGDELLVGVSRRIRTCV
HGEDTVARLGGDEFAVVLEGLSTRQAREVAKRIHDAIGLPIDLAGQEYVGTSRIGISLFSAGETSVEELLKLADASMFQAKRTGRNQIHFFDASMQAALE
ERVRMESWLRKALP-DQLELHYQMQVDSA-GHVFGAEALIRWRHPERGLISPAAFIPLAEETGLILPIGRWVLETACRQLKAWETDPARHLLLAVNVSAR
QFQQPDFVQEVLEVVGATGADPANLKLELTESTLLENIDVVVDKMVALKARGIRFSLDDFGTGFSSLSYLKRLPLEQLKIDQSFVRDVLANANDAAIVRT
IIALGQSLGLDVIAEGVETDAQRNFLAIHGCNYYQGYFFSKPLPLPDFE-----------
>tr|A0A062U955|A0A062U955_9RHOB Uncharacterized protein OS=Hyphomonas beringensis GN=HY29_15140 PE=4 SV=1
--------------------------------------------------------------------LKVSQIALAESEALFREALDHAPIGLLVIDGN
KLISFANRVAGKITGLPVADLVGKP---FADIGILNGLG-AERIRACSQEAEIGLTYEVS-------TPKGEICIRHVRDGRGAVQHSIMRMEDVTAEYQ
HSEALHKANVTISSASEGIVCTDENGLITLCNPVAMRLIGREKNDVLGRRFGDLFRLL-S-NREGDDTANWVDSVRFHSMLELVVAGDKKQPVNMSIAPM
QSADGRPIGSVALLQDASDIIALTKKLRSQAYTDEMTGCHNRRSFEERLREKVNERERRNSKDFLLFLDLDHFKAINDLCGHRVGDNVLRDVSKMLRKNV
RESDLVARIGGDEFGIILYDTDKVRARGVAERLVSEVS-AFRLSHNVFRIGVSIGMVEIQDQLD-IETAMTQADTACYSAKNSGRGRVCDFEEVAEDVSE
TSRSWYHRLLEAVEEKRIILFLQQIVSKGGCV--GYEALMRLR-EKGGIYSPCDFLENARRGGIIPVLDRVMFEHVIQVLRDEEKSALFGQYISVNLSAS
SIADPAFRNWLEDVLDQNIDLVERIWFELTESERMRWTPQEKAFLESLRARGARLFLDDFGTGYNSFEVLKIMNVDGLKLDHSVIKDVITSPVDQALVGA
ALGICRHLGLEIVAEGVETSATASFLASLGVHKFQGYYFHYPEEVSTVEAGYPYSG----
>tr|A0A063BI21|A0A063BI21_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. lig30 GN=LIG30_4784 PE=4 SV=1
--------------------------------------------------------------------KKRLDRALAQSELRYRAARSNAPALIFV----
----AVNPEFCGLCGLPEFRLVDKP---VGGVLS--VLL-HEATVLCEVRTRK----EMRDLR-GPRARWFD-SY-----SPGAGQCAILVQETTHRKWM
QETLSRQH-VTLHSIGDAVIATDTTGRVQYLNPMAEHLTGWQSDAAGNQEIESVFHIF-D-ERTGIQAPNPIAATQLDDGMVLVAKDGRHFSIEDSAAPI
KDADGVTSGVVLVFRDVTEQRRISKEIAYRATHDALTGLLNRAEFEARLQQALEGVRGSPNRGAVFYLDLDQFKLVNDTCGHAAGDALLKRVASHLGESL
DMPHTLARLGGDEFGIILPDCPVSRVEEVATGLCRRLD-AMRFEYKHFCVGVSIGAALLDGKL-AVDAIMQCVDSACYAAKDAGRNRVHVWSETDQAMLA
REMEWVRRLRQAIDENRFVLYAQEIFSLQAAAAKRFEVLLRLPGEQGSLIPPGAFLPAAERFNIASRIDRWVVNQVFRWMAN--YSGQLDEYISVNLSGQ
SIGDMEFLEFLKNLLGRFPVNGSKLCIEVTETAAITNLDAAAVFVNALKKYGVRFALDDFGSGASSFGYLKALPVNYLKIDGQFVRHLDQDALDRTVVKC
IQEVANVLGKETIAEFVETAEVSAILTEMGVGSAQGFFLHRPQPIAIVLTSRSPSA----
>tr|W6M004|W6M004_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Candidatus Contendobacter
--------------------------------------------------------------------ARR---SLQQ-KRSRRLIVNYSPDLIFVLDAA
GHFTYLNQRVPGLLGFEIDALTGQP---LTALVD--AVD-QE-HLLRHLETEKPQFVELRLLR-NAASPYRELAIR-DEGDPSRFIGSYIAARDVSARWQ
AEEALRRA-EHVVSASPAVIYSCDPGPVTFISSNVYELLGYRADELLADEYDRLIHPE-D-RS----HREHDL-HQMNRAYRLRHRYGGWRWIRDTVRLV
CDAGGQPVELVGSWLDNTEAQLLAEQLTHQASHDALTGLANRRAFEQRLQRALESVRDQSAEHALFYLDLDQFKVINDTCGHLAGDDLLRQLARVLQIRV
RKQDILARLGGDEFGVLMEYCPLHDALRVANTLCQAVN-DFRFAWDTFRLGVSIGVVAISAASDNFSGVLSAADSACYAAKDAGRNRVHLYTEDDAELAR
REMQWVARINQALEENRFQLAFQPIVPILGSKGHHYELLLRMEGESGQILMPSAFLPAAERYHLAAKLDQWVVSTALDWLSS--NPHHLDALCAINLSGH
SLGDEYLLDYLVDRLARPPLLAEKLCFEVTETAAIANLGSALHFIQTLKNIGCRFALDDFGSGLSSFAYLKKLPVDFLKIDGMFVEDIVNDPVSLAMVNS
INEIGHVMGMETIAEFVKDDQILTKLRTIGVNYAQGYGIGKPRPLTDLALH---------
>tr|H8Z3C1|H8Z3C1_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiorhodovibrio sp. 970 GN=Thi970DRAFT_02062 PE=4 SV=
-------------------------------------------------------------------------------------LIESMSEGALVLTAE
GLVYYANRRLGEMLKTPHQ-LPGTA---FKQWIKPIDHP-WFDGIEIILATD---GSEMPC-----H---LSVSVLPVGNDQVYFS--L-VATDLAEQKA
HQDRILAAESILDQAAEAIVVCDRTTQVVRANALARQLCGVNPLGLADALP-ELQSGARDLHEFIGDHD----HHPFEAHLALQ---DKTLTLLIGIGPW
LGSDGSILGSIVSLTDISARKSAEEQIFRLAFYDPLTGLPNRRLLEEWISHQTVQYIRSGRHGALAFIDLDNFKTLNDTRGHDVGDLLLKQVAARIKTSI
RESDILARLGGDEFVLILAELDSDPAETVCAKIHREAREPYVIDDYECRSTLSIGITLFGKH-KTLDELLKRADLAMYQSKASGRDTWSFFAPEMQQALE
SRARLEERLRLALQDGGLWLAYQPQIDR-TRHLIGAEALLRWKDGVEGMVSPAVFIPLAEETGLILPLGDWVLDQACAQLAEWAKTPET-LTLAVNVSAH
QFQQPDFVARIRDVIARHSISPNLLKLELTETLLLKDVTEAAYKMEALKALGISFSLDDFGTGYSSLAYLKRLPLDQLKIDQSFVRDLLEDSSDAAIVDA
ILAMARSLGLQVIAEGVETTAQHALLLKQGCNAFQGYLFGRPGPSSQLDSALA-------
>tr|L9PD94|L9PD94_9BURK Signaling protein OS=Janthinobacterium sp. HH01 GN=Jab_2c08720 PE=4 SV=1
-------------------------------------------------------------------------------------ILDALPAQVVVLGLD
GTI------------------------------LAINEA-WRNGIEQVLGEAPSFELEYACHT-PQHQRWFSMSVTPLGYGAAGVV--I-AHHDITERRQ
HEARLRIAA-IAFESTEGMMVTDANSNIVQVNRAFTNITGYAADEVIGRRP-LLSSG-RDAAFYQAMHKAVASTGSWEGEIWNRRKNGEIYPERLHIAAV
RDEDGGTTHYVAALTDITLSKAANDEIKNLAFYDPLTRLPNRRLLMDRLRQVLAASALNGNYGALMFIDLDNFKTLNDTLGHNTGDLLLQQVASRLRTCL
RQADTVARLGGDEFVVLIDGMSRQPTEALGSKILATLNQPYQLGPHHCHSTPSIGATLFHDEQRQPDELLMQADIAMYQAKQAGRNGMRFFDQRMQDTLS
ARAQLENELRTAFDHQQFELFYQGQVDA-DGHATGAEALIRWIKPDGSSISPAQFIPLAEETGLILLLGDWVLEQACRQLRDWQRGATT-LVLSINVSAK
QFRQPDFCARVHSAIERYGVVPARLKLELTEGLLLDNIEDTIASMTALKELGIKFSLDDFGTGYSSLQYLKRLPLDQLKIDQSFVRDLASDANDQAIVLT
IIAMARSLRLDVIAEGVETQDQRQLLAELGCDAYQGYLYCRPLPVPAFQGWLAATA----
>tr|W7VUW0|W7VUW0_9BURK Cyclic di-GMP phosphodiesterase Gmr OS=Methylibium sp. T29 GN=gmr_7 PE=4 SV=1
--------------------------------------------------------------------RKRTELALR--------LADNVPALIAYYEQQ
GFCTFANRHYASALGWTPENILGRT---AAEIV--GERG-WQQYIERVVT-RAQVSYERELTDAAGRPQWLEVDVLPNFDDEGELSGAFVRVTDITKHRL
AERAVRESEKFMQASAEGILF-HRNGTVIDINEPICELTGYTRDEVIGRQT-EFLAP---------DHLPRAQEAAWESVALG--RAGERIPVEL-ITRS
IMRSGE-RLRLVIVRDIRERVAAQARIHHLAHHDALTGLPNRAAFGLQLERLTASHRSGDAQIALLFIDLDHFKRINDSLGHLVGDLLLQTVTARITDNL
RADDLVARFGGDEFMVLIPGVTDRSVEQVAGKLLAVIEAPLEAAGRSISVSPSIGVSLFPEH-GRPAELIQHADAAMYMAKARGRANVQFFDPVVASAAY
DALVVESQLAQALETGAFELHYQPQLRSGDGRLVGVEALIRWHHPERGPLLPDDFIPVAEERRLMLPIGQWVLREAMRCARRWHAQGLEL-PISVNLSSM
QFQQRGFVDSLAELLRQEQVNGAWLELELTERMLMDDLDEVKATLAQLKALGMRISVDDFGTGYSSLGHLKELPIDKVKIDRSFVQDVPQNADAAAIVRA
IVQLGRSLGMTVIAEGVETEVQERFLRELGCEELQGLRIAPPLSEADLQLWASRR-----
>tr|A0A059KRN2|A0A059KRN2_9BURK Diguanylate cyclase/phosphodiesterase OS=Sphaerotilus natans subsp. natans DSM 6575 GN=X805_02940 PE=4 SV=1
--------------------------------------------------------------------PQVAEPTFR--------LADSAPVLMAYCENE
ALCSYANRAFVQSLCPAASEPIGQP---LAGAVTPDLAD-WLQ--AQLED-GEAVCNEQWLTLADGTVIWAELTLAPHVDARGRRHGLYLLVSDHSRHHH
AERALLESERFMQAGVEGIVF-HRDGHIVDANPALCTLIGQSLHELLDRPL-GLIAP---------ECQSRLADLCIETSLIA--KDGRRIPVEL-IERG
TLQRGA-PMRMTVLRDIRERRDVQDQLHYLEHHDALTGLANRHALFSQLEHLMVAARASDTRLALLFIDLDHFKRVNDSLGHAAGDALLKTLASRLGERV
RSTDRVARFGGDEFIVLLPGVRSREIAHVARKLLEALARPVRIAGSDISITPSIGIAVYPDD-GDPDVLIQHADAALHAAKAQGRAHSVFFEPRQVSLAR
DNLVLEGQLGQAIAQQEFALLFQPQVCARDGRFVGVEALIRWNHPERGLLVPDAFIALAEQHRLIVPIGAWVLREAARQARLWHEAGLPL-TVAVNLSTL
QFQAPDFVASIEQLLAETALPPGWLELELTERMLMDDVPGVLARLAQLRQLGVKLSVDDFGTGYSSLSHLKELPIDKMKIDRSFVRELPHQRESAAIAGA
IIELARGLGLTVVAEGVETEAQREFLLAHGCDQLQGMGIGAPMDAAALQAWQRART----
>tr|H5WKR6|H5WKR6_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Burkholderiales bacterium JOSHI_001 GN=BurJ1DRAFT_427
--------------------------------------------------------------------RADVDPAAH--------LADHVPALIAYYERN
GFCLWSNRAYAHTFGFTPESIVGRS---FADVVGPEAAL---LHVDAMLE-GRTAGYERHLTTASGEPRWISVSLVPHRPPDGDIVGAFVLISDITRHHL
AEAALRESEKFMQASVEGIIF-HRDGVVSDANAALLALLNAPFEAVVGRHI-DFVAP---------AHRARAQDVNYEIDVLD--SDGQVLQVEV-MGRT
ITRRGE-ALRMVIVRDIRARLAAQARIHHLAHHDALTGLPNRLAFEQQLEQTLAG---GRTQAALLFVDLDHFKRVNDSLGHLAGDALLRTVAERLLATL
RPGDVVGRFGGDEFMVLLPDVVDPAVEDVVQRLLHAIEVPMRVQGQAISVTPSIGVALYPRD-AAAEELIKNADTAMYLAKTQGRAGCRFFEPDMAAQAF
DAIVLEGDFARALERGELMLMLQPRQHLQPCAARAVQALLRWQHPQRGLLAPESFNDVALERRMVQPLAQWAVGEALRLGLRWRGADAASPTLVLDLSPL
PLTAAVLAAALAGHSQGSPLPAGWLALDLSERMLAEGLDDAGQPLQQLARLGVALAVSDFGSGQLPLSQLPRLPVRCLRLGAALVGRLPQDGPSTTVAGA
IVQMACGLGLEVCADGVSTPAQRDWLRQQGCTMVQGPLVARPMPPAMFEDWQRAPP----
>tr|A1WX01|A1WX01_HALHL Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halorhodospira halophila (strain DSM 244 / SL1) GN=Hhal_1446 PE
-------------------------------------------------------------------------------------LFLQSEDGMLVLR-D
GHFVACNPAAARM----------------LG---------WDDRVQSLLAAEGAQRFEWIHTSPEGGRLWFEIVLTPLHLDDETLC--CATLRDISRRKE
MERRLQLSAKVFTATRDGILITDADSRILQVNDAFTRITGYAEEELLGRTP-VLQSG-HDADFYRVMWESIHQQGSWSGELWDRTKYGTLQPKWVTISKV
TGAYGEVINFIAVFSDLTELKRSQERLQFQAYHDALTGLANRLLFKDRMARALERSRQSEEQLAVLFIDLDHFKDVNDSLGHTAGDRILRQVAHRLQARL
GADDTLARLGGDEFSICLAEIRDHR--ACAETVHQELERPFQYSQRWFQCRCSIGISMYPDN-GEVEELIRNADSALHNAKAEGRNTTCFYAEELTERAQ
RRLDLAQEMRQGLQRGELIPYFQHQVDLTTGRVVGIEALVRWHHPERGLLTPGAFIPVAEEVGTMAALGEDILLQACQQGRTWLDQRRE-GRVAVNLSAA
QFHNGDIEKTVRRTLEQTGLPAQCLELEITESTIMDLSPRTLERLAALRRAGVSLSIDDFGTGYSSLLYLKRLPINRVKIDRGFIWDMGTTPESRSIVDT
ILQLAHVLGLEVVAEGVETIQQRDQLIDAGCRVAQGFLWARPEPHPHLRCCSAQAS----
>tr|Q1JW15|Q1JW15_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_0260 PE=4 SV=1
--------------------------------------------------------------------RKRTEESLVEAETRLTEILNTMMAGILIIDPQ
THIVDVNHMASQMIGDPPDKIIGAI---CHRYICPSSSTDLNQV-----IDNS----DRVLINNRGEEIPILKTATII-ELNG-KAFILESFIDIQARKL
AEQALRESETAMEGVAIGELVYDAHGILHDVNRAFSEMLGVASEELVGHRASEFYHG---APPYIHILDEVVKYGIPKEY-------ELPLSDLEKVFHV
SVSRPEKERFACIINDVTDSKKAQQEIERLAYYDTLTGLPNRVLIKDRLQQAVAQAQRSRALVGVLALDLDHFKKINDSLGIGCGDQMLKLVSQRLKGHL
RQGDSVARMGGDEFVILITGIKSNDIVTAAGKILDLLAEPVTIDGHDLVSTGSLGISVYPTDADEVDLLLKHADTAMYQAKETGRNLYQFYSPDMNERAF
ERLFLDSDLHRALARNELELYFQPQIDLAQGHVVGAEALLRWNHATKGQISPVVFIPLAEESDLILDIGGWVIEEACRHARQWHDQGYTDLRVAVNLSAR
QFRS-DLPDIVARVLHETGLPAHLLELELTESLLMERPELARTILNKLRYLGNHLSIDDFGTGYSSLSYLKHFPIDRLKIDRSFVKDLNVDPDDAIIVEA
IIALAHGLRLNVVAEGVETSDQFEFMRQRGCDEIQGYVVARPMPADDFLRYLQK------
>tr|Q1JZ53|Q1JZ53_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_1303 PE=4 SV=1
--------------------------------------------------------------------VHRYKEKLESLSVEYQDLFNTVADGLVVRDVN
GHFLMANQAFLSLLGYREEELIGTH---CTKVCKDK--ERFAEI-----LQGRTIVFKSTHTTRNGEKIPVEVNSTLV-SFKG-DTAVLSSVRDIRERLE
KEEQLKQLMTVVENSNDGVLVTDVTGSIIAVNRAFCRISGYDEEDVLGKTPRMFQSGIHDKSFYQAMWNELAQYGQWQGEIWNRNKDGESYPEMLSIRAL
TDDAGTVYRYVGIFADLSNEKALEKKVLHLAQTDPLTGMANRVLFRDRLQQAIKHAQRHVTTLAVYSLGLDHFKKINDSLGHVIGDKILIEVAKRLKKCL
RGEDSFCRHSGDEFTLMTYGGADMDASTVATKILNAIRLPFIVDGSELFLTASIGIALFPRDSSDDLGLMQKAENAMHQSKKNGRDCFCYFSREFSQQAE
QALHLTNMLHKALEKEELQLYYQPQVDLESRAIIAAEALLRWHNDEMGWISPAQMIPIAEESGLILPIGQWVLEQVAQQIRSHYETNKEWLPIAVNISVK
QFITDDFIEMVMKIIDAHAIPARCLELELTESLMLADVELAVKKMGELHTLGVPLALDDFGTGYTSLAYLKRFPVNKIKLDRAFVTDIHHSKGDAALAKS
LVAFTREMEFELIAEGIEEEIQGEYLKAMGFRYGQGYLYSRPLPKEEFSKLFTN------
>tr|Q1K008|Q1K008_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_2434 PE=4 SV=1
--------------------------------------------------------------------QYHSQLKLKELQEEYRTLFDYSVDGLTVRNLN
GELLLCNKSYEEMLGRTFAELNHQH---FTKLCDPQEKEKYREA-----LEGKSILFEFTYEHKDGHHFPVEIRSIVI-DYRG-EPCVLTAVRDISERRE
KDQRLRELSAVVDHSNDAVMIMDDSGNVLAVNKTFCDLSGYSEEDLLNRLPLFLRAERHDRVFYTDLVKQLRDEGRWEGEIWIRHHRGHSLPQWLRIETV
EEPENKTTRYVAVSADLSEEKAWEEKMLQLAQTDPLTGSANRVLFRDRLQQAIKRAQSRGMEVQVFSLDLDYFKRINDSLGHVAGDRMLIEVAARLKRVS
RGQDTISRLSGDEFAILVTCLNDVDATRMAQKMLQAISEPMMIDGAELIITASIGVALYPGDGDDDVTLMANADNAMHQAKRQGRSRMCYFSAELADKAQ
EYLTIESKLRRALENSELQLYYQPQVDLATGDIVAAEALLRWHSDELGWVSPDRMIPVAEEGGLIIALGRWIIEECCRTIRGYHRSSGNWFPIAVNVSAR
QFLEPGFTDELVEIVRFYDIPPSLLELELTESMMLDDVGKAIETMKALSFKGFKIALDDFGTGYTSLAYLKQFPVSKLKLDRAFVTDVHRDVNDAAIAEA
LVTFTRVMGLSLVAEGIEESVQHECLNLMGFRFGQGYLFSRPLPKDQFISLLET------
>tr|B9Z0J4|B9Z0J4_9NEIS Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Pseudogulbenkiania ferrooxidans 2002 GN=FuraDRAFT_0616 
------------------------------------------------------------------------TAQWHDSQDHLRNVISSVPALVAYVDAQ
QRYVYVNDQYRERFAPGMTDITGCE---VKAILGEARYAIAEPLIG-KVLQGEAQGYDW----QPFPGVWQTIRYLPKYDAGGQIVGYYVLGTDITERKL
AEERIRTLNRAMLRADEERALLD------AMCHAIVVDGRYDMAVVWYGDKRPMAGDERGQSV----SPMAMRTGKV-QLVRDMGSD-PHSRWPGDIALL
TESSEDLAFGIATLRNHVEQKRTQAAMHHLMRHDPLTGLPNALQFEEALSAALRTSMQEAQPLATLQLNIERLSEINDALGFVYGDQILCDFGFRLQGCV
PATALVARIRGDEFAVLLPGSDAQAALTAVEAVELELARAFPVADIALDVSAKTGIALFPEHGTTTHDLLRRMDKAVNQAKKRGLSHVVF-DPGEAHAQA
DRLVMMGELRRAIEGGELRVYLQPKVEFATGRVSGAEALVRWNHSRLGLLAPAMFIGLAEHTGLIRPLTEWVIGATLDLLQSWHARGCA-VPIAVNLSAR
SLHDESLLDKIRLWQAARGIGPGWLEVEITESSVMEDPELALGILHSLHAGGIPLYIDDFGTGYSSLNYLQKLPVDYIKIDQSFVANMSRSKDSAMIVRS
TIDLVRDLGRKTVAEGIETQEHWEQLSRLGCDYAQGYFIAKPMPAEAFQEWVENFIPP--
>tr|S2XUQ1|S2XUQ1_DELAC Uncharacterized protein OS=Delftia acidovorans CCUG 274B GN=HMPREF9701_00951 PE=4 SV=1
------------------------------------------------------------------------TAQWHESESHLHSVISTVPAMIAYVNAA
QRYVYVNAQYLERFAPEREDIAGCT---VREIMGEERYATVGPLID-KVLSGEPQAYDW----QPFPEVWQTVQYVPKRQADDQVAGYYVLGTDITERKR
SEQHIQALNRTLLRASEEQDLLE------SMCRAIVTAGGYGMAVVWYRGDRPMTDTELGRGL----TSTAIRSGQI-HIVRDMHSD-PDQAPWHDVALL
TESADDLAFGISTLRAREEQRRVQAAMHHMLRHDPLTGLPNALEFTETLATAVEGVSPSAEPLAALQLNIEGLGEINEVLGYSHGDQILRDFGQRLRECV
PGAAHIARLRGDEFAVLAPAQDGAAALALAQRVETSLSRPFPVADIELDLGAKMGIALYPEHGATAQELLRRMGKALYRAKAQGLNQCLF-DASQQGDHA
GRLTMAGELRRAISGGQLRLFLQPKVEFASGRLCGAEALVRWQHPEQGLIPPGVFIGLAEQTGLIKPLTEWVIVAALDLLRDWQAQGQS-TPIAINLSAR
NFRDDQLFSKYRRWQAERHVTPGLMEMEITESTVMDDAEYALQVLHALHDEGIPLYVDDFGTGYSSLSYLQKLPVDYIKIDQSFVAAMPHNRDSAMIVRS
TIDLVHDLGRKTVAEGVETQEHWDMLAHLGCDIAQGYFLAKPMPAQAFQAWAQGFRAP--
>tr|Q21RH2|Q21RH2_RHOFT Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 1
------------------------------------------------------------------------TIQLHESEDHLRSVISNVPVMIAYVDAQ
QRYIYVNQSYRERFSPGQADIAGQT---VRDILGHERYAVAAPLIA-KVLQGQPQSYDW----QPFPGVWQLVNYVPKRDAREGVVGYYVLGTDLTERKH
AEEKIRTLNRTMLRATVEQGLLD------NMCRAIVANGGYQMASVWYRIDRAMADNEYGGGA----VASAIRTGQA-SVVQNILAD-PNYAPWRPVTLL
TESADDLAFGIATLRARAEQQKIQQAMERLTRYDALTGLPNETQFTEFLAAAIDAAKRLNQPFAVLQANVERLSEINDALGFGHGDQLLREFGARLCVAA
PASAMVARLRGDEFAILLPDSNANSVITMLQRVEDVLAQPFPVADIAPDVSAKIGVALFPQHGATPHDLFRHMDMAVHQAKKKGVKHAIF-DPDLNQDQS
RRLTMAGELRRAIEGGDLLLYLQPKVEITTGRLCGAEGLVRWKHAERGLIPPGEFIGLAEQTGLIKPLTEWVIKTSLRLNQAWQYEGCA-LPIAVNLSAH
NLHDERLLQTIRHLQTTYGVAAGLLELENTESAVMDDAEFALRVLHSLRDEGIPLYIDDFGTGYSSLSYLQKLPVEYIKIDQSFVRDMTISRDSSLIVRS
TIDLVRDLGRKTVAEGIETQEQWDQLAACGCDIAQGYFIARPMPAEDFQNWVKQFRAP--
>tr|A0A096DPQ0|A0A096DPQ0_COMTE Diguanylate cyclase OS=Comamonas testosteroni GN=P368_20510 PE=4 SV=1
------------------------------------------------------------------------TLQWHEIQSHLHNVISAVPALIAYVNAQ
QHYEYVNTQYRECFAPDREDITGES---VRKILGEERYVVANDLIG-KVLAGEPQTYDW----QPFPGVWQTIQYVPKHQADGTVAGYYVLGTDITERKH
YEERIQTLNRTMLRASEEQSLLE------NMCRAIVAAGGYGMAAVWYSGNRPMADTELGQSL----TSSAIRSGKV-QFVRDMRVD-SNHVRWSDIALL
TESADDLAFGISILRTRSEQLRVQAEMNHMLRHDPLTGLPNSIEFREVLTAKIEGSSSHPEPIAALQFNIERLREINEVLGFSNGDQILRDFGERLRQSI
PDSAHIARLRGDEFAVLAPTLDRGSAVALAEELEKNISRPFPIADIELDVSASAGIALFPEHGTTADELLRQMGKATHQAKARGLSQCVF-DPSHQKNQA
GRLTMAGELRRAIAGNQLRLFLQPKVDFSSEQICGAEALVRWMHPLKGLIPPGLFIDLAEQTGLIKPLTEWVIVAALDLLQSWQAKGCA-VPIAINLSAR
NFRDEQLFAKYRQWHSERSVSTGLLEIEITESTVMEHAEYALRALSEMSDAGIPLYVDDFGTGYSSLSYLQKLPVDYIKIDQSFVSAMHRDRDSATIVRS
TIDLIHDLGRKTVAEGVETKEHWDLLKDLGCDIAQGYYIAQPMPSSDFQQWAEDFTKC--
>tr|C5T9K8|C5T9K8_ACIDE Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) OS=Acidovorax delafieldii 2AN GN=AcdelDRAFT_3588 PE=4 SV
------------------------------------------------------------------------TAQLQESEGHLRNVISNVPAMIAYVDAH
QRYVYANRQYQQRFAPDQPDITGLE---VREVLGPERYATAGPIIA-RALQGEAQNYDW----QPFPGVWHAISYLPRRDAQDSVAGYYVLGTDITDRKQ
TEEQIQALNRTLLRATSEAELLD------GMCQAIVGTGGYHMAIVWYRADQPMADNQ---GA----VATAIRTGEP-VVIPDVRNN-PHYGPLRPVALL
SESADDLSFGISTLRTSALQQRTQEAMDRLAHYDTLTGLPNELLFTQWMASAIAG----AKPFAALQVNIERLSEINDALGFSQGDQVLREFGARLRAAA
PASASVARLRGDEFALLLPGGDAATAIAVVQQLGRSLAQPLALADIFLDISARTGIALFPAHGSTPHDLYRHMDIAMHQAKMRGLDYFVF-DPARDPDRS
HRLNLAGELRAAIEHGDLDLHLQPKVDMATGAVCGAEGLVRWHHAERGLILPGEFIGLAEHTGLIKPLTEWVIATSLQLNQQWMREGRA-LPIAVNLSAR
NLRDENLIDIIRQLQRASGVTAGLLELEITESTVMEDAAFALRVLHGLRDEGIPLYIDDFGTGYSSLSYLLKLPVDYIKIDQSFVRDMPDTKDAALIVHS
TIDLAHDLGRKVVAEGVETRQHWDQLAAFGCDHAQGYFLARPMPAHELPGWLAGFQPP--
>tr|J1EEG2|J1EEG2_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_04685 PE=4 SV=1
------------------------------------------------------------------------TAQLRASEDHLYSVINSVPAVLAFVDVD
QRYVYVNAQHKALYAPDRDEVRGRT---VREIIGEERYAHAAPMIE-RVLQGERQSYDW----QPVPGMWQAIECIPKRDDSGRIQGYYVLGSDITVRKQ
AEDKVLALNRTMLRAVDEQDLLS------SMCEAIVTAGGYAMAVVWCRPAVPVQAGDMGQGV----LGDAFRSGLA-SVGQGGEPPGLDGPAWLAITFL
VESADDLAFGVATLRHRSEQARVQEAMQQMRRYDALTGLPNEAQFTEILVSAINA----GQQFAVLQANVERLSEINDALGFCYGDQILQEVGARLVHAV
PASATVGRLRGDEFAILLPQCNAQAAVAMVRTVDAVLAQPFPIADISMEVSVTAGVALFPAHGETPHDLYRHMDTAVHQAKKAGVGHVVF-DPAKSQNQA
HRLQMAGELRRAIENGDLALYLQPKIDMVTGQVRGAEGLVRWRHAERGLLMPGDFIGLAEHTGLIKPLTEWVMEASLRLNHGWAAKGVA-LPIAVNLSAR
NLRDESLLQTIRQLQAAWPLAPGLMELEITETTVMGEPERALRVLQALRDQGIALYIDDFGTGYSSLSYLQQLPVEYIKIDQSFVCDMSVSKASSVIVRS
TIDLAHDLGRKVVAEGIESQAHWDQLAALGCDIGQGYFLARPMPAQELPGWVAGFVAP--
>tr|H0Q0P7|H0Q0P7_9RHOO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Azoarcus sp. KH32C GN=AZKH_0198 PE=4 SV=1
------------------------------------------------------------------------TAQLRDSEDHLRSVIRNVPALIAYVDAE
QRYVYVNEQYRARFASDRPDITGCT---VREILGEERYAIASPIIA-KALLGEPQSYDW----QPFPGVWQLISYAPRRDADGGVAGYYVLGTDITARKE
AEERIRSLNRTMLRATDEQELLD------GMCRAIVETGGYDTAVVWYRLHRAMADNEHGRGA----VGTTIRNGQT-RVVRDIAND-PNYAPWRAVVLL
TESADDLAFGIATLRVRAEQQKSQEAMYRLTHFDTLTGLPNETQFTAAINAALESGKQSDAPFAVLQANIERLSEINDALGFRHGDDMLREFGTRLRSAA
PASATVARLRGDEFAALLPAGDASAALALVSRLEQALAPPFPIADIALDVSARIGVALFPEHGTTAHDLYRHMDIAVQVAKKKGLGHVMF-DPAQNPTQA
RRLTLVSELRRAIEHGDLLLYLQPKVELASGRVCGAEGLVRWKHAERGIIPPGEFIELAENTGLIKPLTEWVVETAMRLNQQWARQGRE-LPIAVNLSAR
NLHDEKLLEKIRHLQAAYGVCAGLFEMEITESAVMEDAEFALHVLHGLRNEGIPLYIDDFGTGYSSLSYLQKLPVEYIKIDQSFIRDMSSRKDCELIVRS
TIDLIHDLGRKAVAEGIETRESWDRLAELGCDVGQGYFIARPMPPEDFMAWAERFPAH--
>tr|F5RD66|F5RD66_METUF Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor OS=Methyloversatilis universalis (strain ATCC BAA-1314 / JC
----------------------------------------------------------------------------RNSEDHLRNVISRTPAIIAHVDAR
QRYVYVNARYLERFAPGRSDLTGLT---VREVIGEARYAVVAPLIG-RVLQGEPQDYDW----EPFPGEWQFISYLPRFDERGQVTGYYVLGADITGRKR
AEARIRQLNRAMLRATGEHDLLD------SMCRELVDKGGYPMAAVWLSDAVPTAAPV----------IEALQAGDRICFAQD-------CLPLPLRSLI
RESADDLAYGVTSLRTR-------EQMYRLTQYDTLTGLPNQMLFGELLTAELEDSLRMARPFALLQMNIERLSEINDALGFGQGDDMLKEFGRRLGEVA
PPGASIARLRGDEFALLLPASGRAAALAMAQRLRAVLSQPFALAELPIEVSTRIGIALYPDHGSTPHDLFRHMDIAVRHAKKRGVDCMVF-DPDCYQGPS
HRLNMAGELRRAIEAGDLRLHLQPKVDMRSGRVCGAEALVRWQHPQRGLIPPAEFIPLAEQTGLIQPLTEWVLERALQLNAGWEAVGRA-LPIAVNLSAR
SLRDEDLVDRIRQMLGHWTTRSGLLEIEITESALMEDAEFALGVLNGLRAEGLRLYIDDFGTGYSSLSYLLKLPVDCIKIDQSFVRAMTGSSESAVIVRS
TVDLAHDLGRKVVAEGVETRQHWDALAALGCDVAQGYLIARPMPAEQFQDWVGGFRSP--
>tr|Q39R25|Q39R25_GEOMG Sensor diguanylate cyclase/phosphodiesterase, PAS, PAS and PAS domain-containing OS=Geobacter metallireducens (strain GS-15 / A
----------------------------------------------------------------------------------LDTLIQASPQGIVAVDCG
GKVTLWNRAAVEIFGWSAEEVLGKP---YPVAPAERAAEHRK-LRE-LVLQ-GKRITDVELRRKDGSPIDVSLSAAPICDGSGTPLGVITIISDISARKR
NEQELVL--RAMESSINGITITDATHPIIYVNPAFERITGYGVDEVIDKNPRFLRGDDRDQAE----LKAFKEEREGCFVLRNYRKDGSPFWNELFIAPV
RDRDGVVTNYIGVMNDITEHRRYEEQLVYQATHDPLTGLPNRNLLQDRLGQALALAFRRRNPICVMFLDLDNFKKVNDTLGHTVGDMLLKAVANRLKNCL
RGGDTVARLGGDEYIIVLPNVREPDVITVAKKMINVFAAPLLLMGNEIYVTASIGIALFPTDGETVDALLKNADAAMYHAKEQGKNNYQFYSAEMNIRVF
ERLSLETSLHRAVKNQEFLLHYQPRVDLRNGRICGVEALVRWNHPEMGLVSPAKFIPLAEETGLIVPMGEWVLRTACAQNKAWQDAGLP-PRMAVNLSAR
QFRQENLIAMVEEILMETGLAPQWLELELTESLVMQEAEKSAAILRELTDRGIEVAIDDFGTGYSSLSYLKRFPIANLKIDQAFIRDMTRDPDDATLVKT
IITMAHGLGMKTIAEGVELAEQIDFLCRHQCEEMQGYYFSRPITAEELGRLLADGKTL--
>tr|S7V6R8|S7V6R8_9DELT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio sp. X2 GN=dsx2_3360 PE=4 SV=1
----------------------------------------------------------------------------------LQSILDALPQPVFYKDAH
GIFQGTNLAFQRFFGKSRDEILGRT---IHDLAPEGIADIASRHDR-MLLENPDEVHVSEMPDAADRQVEALFSKAAYRNAAGVPVGIVGSFLDITRRKR
AEEALQEANEVFLHSLDGILITDAKGAILQVNPAFSRITGYAPEEVLGQNPRVLKSDRHEEGF----YGNLLRDGQWEGEIWNRRKNGEAYPEWLSISAI
RGEDGQVAHFVAVFHDISEIKRSEELMKHQAYHDALTGLPNRLLLLDRLGVSISHAKRAGTRLTLLFLDMDNFKTVNDSLGHSLGDLLLMAFAHRLRRLL
REQDTVARLGGDEFVVLVEDVESAAAVAVGERILEALRRPFTVKHHELFITASIGITLYPEDGDTPETLLKNADLAMYRAKEQGRNSCQLFTPAMNERAH
ARLDLERSLRRAVGQKDFTVWFQPKVHLATGTIIGAEALVRWPRKDGSLVQPDAFIPLAEETGLITTIGEQVLEKACLEAKAWHDAGLA-HAVAVNLSMR
QLSQKGLVEHIAGVLERTGLDPALLEFEITETAIMSRVEQAVAVLRDIRDLGAQITVDDFGTGYSSLYYLKRFPIRGLKIDKSFVSHLPDNGDDLAIVRT
VISMAASLGLHVTAEGVEVAAQAETLRALGCEFAQGYLFGRPMPGPDFLRLLRESGGT--
>tr|G4F326|G4F326_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halomonas sp. HAL1 GN=HAL
-------------------------------------------------------------------------AALQLNEQRFRSLFTQNPDAVFAHHRD
GTYESLNPVTEAIVGLSESDLLGKH---FRSVVCEQDVERTETAFNRAV-NGLPSSYTMRFVRVGG-YQDLEVTMVPIV-VDGEVNGVFGIAKDITDRVA
AEERLHILERSLAASGNGAMIIDVEQQVVYVNPAFTRITGYLEQEVIGHAPLLLSSAETDTADTEQIQAAFQHGTSLSTTVRTYRRDGSPFWNQLFLSPV
KDANQRVSHFICIINDSSERKEQEGQLAYQATHDVLTGLGNRALFSDHLAHDVELAARNGQTLAVLFVDLDEFKPINDTLGHNVGDQLLISVAEKLQQGL
RASDTLARLGGDEFVLLLPDLSHDEAEEVAGRLLDALNKPHRVSGHELHVSASIGIAINRGGIDEPERLLQHADMAMYKAKQQGRNTYEVYTDDLDRKLS
QRVTLRSELQEAIEHGHLNLHYQPLINR-EGDVDGLEALVRWYHPTKGFISPATFIPIAEETGQIIPLSRWVMRQACKDAQQLVAQGLLTGRMAVNLSPL
QFHRPNFLSTLRNVLNETHLAPEHLELELTEGILMRDADGAIDILHALSSMGVSTAIDDFGTGFSSLSYLRDLPIDKIKIDRSFVQDAAKSDKNAAICQG
VITLALELDLRVVAEGIETVEQHDYLMSLGCEVFQGYLFAKPMPLDSLITWLTQK-----
>tr|U7G1D1|U7G1D1_9ALTE Uncharacterized protein OS=Marinobacter sp. ES-1 GN=Q666_02120 PE=4 SV=1
-------------------------------------------------------------------------REILTAEQRFRSLFTQSPDAVFAFDRE
GVYQAVNPAAQELVGFTEKNIGVTC---YQDVLTSGDFAVFDTAFRNAV-AGHPQGFEVSFKNASGEIRLFDVAFVPTV-VDGEVVGVFALTKDVTERHE
AQEAQRILQRSLESSDNAVVVVDVDLPVVFANPAFSEVTGYTREEVLGSPVRLLTGPATEDAAMEQIREAVRAGQPATVILKSYRRDETPFWNHVSLAPV
KNDKQEITHFTAIMTDISEKKEQEHRLAYQATHDVLTGLGNRSLFEDRLEHDFALARRNSQQLAVLFIDLDEFKPINDTLGHKVGDGLLISIARRLDKVT
RPEDTLARFGGDEFVLLLPDLTSAQAEEVANRILDEIADPHQVGSHELYISASIGISLLDEHLDSPEKLIQQADMAMYKAKQQGRDTCEVYSEDLDTKLS
KRVALRNELQEAIKTGQLFLNYQPQVDQ-DGHLCGLEALVRWKHPEKGFISPADFIPVAEETGQIAHLGKWVTTQACKDARRLLEMGLLKGRMAVNLSPL
QFHRPGFLTALRSILEDTGLAPEHLELELTEGILMKDSEGAIDILNALNGMGVATAIDDFGTGFSSFSYLKDLPVDNIKIDRSFVDNVTTNEKDAAVCKG
VITLAREMGLNVVAEGVETQEQFCYLKSHGCESFQGYYFARPMVFEDLVQWIGKS-----
>tr|M7CSY0|M7CSY0_9ALTE EAL and GGDEF domain-containing protein OS=Marinobacter santoriniensis NKSG1 GN=MSNKSG1_11428 PE=4 SV=1
-------------------------------------------------------------------------RELSVAEQQFRSLFSQSPDAVFAVDER
GYYRSLNSMAERIVKLGIDDVGTTH---FRDVLDAQDRERFESAFRNAA-SGQTQSFEISFTSPDGSSRDYEADMLPVL-VDGTVSGVFIIGKDITERLK
AQDSERILKRSLESSDTGVIVVDHDLPVVFVNPAFCQMTGYSESELLGATVKLLAGPETDRKDIELIDRATQAGQPLSLTMKSYRKDGTPFWNQVSLAPV
TDDHREVTHYTAITRDISERKEQEGRLAYQATHDALTGLGNRALFEDRLEHDFSLAKRYGKLLAVLFIDLDEFKPINDTLGHKIGDQLLISVAVRLKRIL
RPTDTLVRFGGDEFVLVLPNLGHREAEEVAERILGELSKPHVVGRHELHVSASIGISLLADGMEYSERLLQQADMAMYKAKQQGRDTYEVYSPDLDDSLS
KRVVLRNDLQEALKTNQLFVHYQPQVNL-HGILCGLEALVRWKHPTKGYISPAEFIPVAEETGQIIQIGKWVTAQACKDARYLVERGLLKGRMAVNLSPM
QFHRPNFLTTVQEILEETGLSSEFLELELTEGILMKDTESAIRILNALADLGIATAIDDFGTGFSSFGYLRDLPVDKIKIDRSFVSQIATSEKDAAVCKG
VISLTRDMGLKVLAEGVETKEQATILSDYGCAVFQGYYFAKPMALKELTFWLTDA-----
>tr|E4PIC7|E4PIC7_MARAH Sensory box/FOG: EAL domain/GGDEF domain containing protein OS=Marinobacter adhaerens (strain HP15) GN=HP15_68 PE=4 SV=1
-------------------------------------------------------------------------KTLALSEQRFRSLYDHNPDAVFSLDAD
GRYRDINPATKHSLGVPNCELRGRH---FTERINKGDLKEVFRAYTEAT-RGYPRTDFSMSLRTSGHVRHFDVTFLPIV-IQDRIDGVFAIAKDITKRVR
TEEQQRIMQRSVEASSNAVVITNAGFPVVYVNPAFSQITGFGSEEVEGQSLGFLIGEGSEDDDIERIKVAVREHRSVSVTMRSYRKDGAPFWYQLFLSPV
RDDEGEVTHFVAVINDISEKKEQDEEMAYQATHDLLTGLANRSLFNDRLKHDFELAKRHSQSMAVLFIDLDEFKPINDTLGHRVGDKLLVSVAERLNSLI
RPSDTLARFGGDEFVLLLPDLEEGLAEEIAERILQELAKPHQIDNNELHISASIGIATNSHSSRFPEKLLQRADMAMYKAKQQGRDTYEIYSADLDEALS
TRVTLRNDLQEAIKGDQLRLHYQPLVNA-DGSIVSLEALVRWQHPQKGSISPADFIPIAEETGQIVPLGKWVTRKACEDALILIERGLRMGCMAVNLSPM
QFHRPNFLNVLRQILEETGLPPEYLELELTEGILMKDTGGAKNILNDLRGMGVKTAIDDFGTGFSSFGYLRELPVDKIKIDRSFVEDVTSCEKDAAVCKG
VITLARELGMRVVAEGVETEEQYRYLAKHGCTGFQGYYFAKPMALDELIVWVEEN-----
>tr|A0A0D6E724|A0A0D6E724_9GAMM Uncharacterized protein OS=Halomonas sp. R57-5 GN=HALO1879 PE=4 SV=1
-------------------------------------------------------------------------RELQDSEQRFRSLFTQNPDAVFSLDLS
GYHLSVNRSVLTLLEINEAQIIGSH---WKEVVAP---SIVGTAFQQAL-MGIAQRFDLEIISQQGNVRQLDVSFLPTV-VMDQVVGVYGIAKEMTALRQ
KESQLRIYQRSIEASSNGILICEADYPIVYVNPAFVAITGYSLEEAKGRNCGFLQGQDTDPEQMTDIQHALTQQHDITLTLRNYRKNGQAFWNNLFLSPV
RSHNGHITHFVGSINDISERRDHENALAFHATHDALTGLGNRALFEDHLRHDVELARRHNQHLAVLFIDLDEXKPINDTLGHGIGDQVLINVARRLEQAI
RPSDTLCRFGGDEFVLLLPDLHSQQAQDIGERLLEALALPYCIDRHELYLSASIGIALNDKQLAQPEELLQQADMAMYKAKQQGRNALQTFTQDINQKLT
QRVTLRNELQEAILNEQFELHYQPLLTA-DGHVKGFEALVRWNHPTKGAISPVLFIPIAEETGQIIALSQWVIERAARDFLRLRPRLPSHCRISVNLSPM
QFHRPSFLSSLSATLEATGLSATSLELELTEGILMNDTDAAIETLHALREMGISVAIDDFGTGFSSLSYLRHLPVDKVKIDRSFINNIANNSKDAAIVQG
IIALAHHLDLTVVAEGVETPQQQQQLMALKCDVFQGYLFARPMPFEALQAWLASH-----
>tr|A0A0D7V0W3|A0A0D7V0W3_9GAMM Response regulator receiver protein OS=Halomonas meridiana GN=VE30_05410 PE=4 SV=1
-------------------------------------------------------------------------RELEESEQRYRSLFVHHPDAVFSLDKS
GYFMTANTTCGKVIGFPLEEVVARH---FSDFVEEHGRDYIKSYFKHVL-QGGISRNEITITDSQSQRRILDLISLPIT-VNGSVEGVYGIAQDVTEKRR
QQTRLRILERSVEASVNGVVIADADVPIVYANQAFSTMTGYSQSEVIGQNCRFLQGPDSDPAMVAKLRCGIQEQRETQVTLCNYRKDGTPFWNDLYVSPV
RDDQGHITHFVGVQHDISQHKAYEARLAYHATHDDLTRLPNRMQFEEKLHQRFAHAQESGERISVLFVDLDDFKPINDTLGHAVGDQVLIEVAKRLRAAL
RQADTVARLGGDEFVLLLTNIVDGQVIDVAERLLPALAKPYCIAGHELYLTASVGIAMSQPDTPLPQTLIQQADMAMYKAKQQGRNAYAWFSNDINEQAR
ERVSLRNDLQEAIDHQGFELHYQPLMDR-QGQIASVEALLRWPHPTKGYISPARFIPLAEATGQIMPISEWVLQRACKDMLKLQRSGLGELRVAVNLSPL
QFHRDSFLATLRQTLLDTGLPAEQLALELTEGILMDNTDAAINILNELHTMQVSVSIDDFGTGYSSLSYLKHLPISTIKIDRSFISEITSSDGDSAIVQG
VISMAHHLGLNVVAEGVETNEQHQRLLAYRCDLFQGFGLAKPMPLAELERLMAEQ-----
>tr|A0A0B1PM36|A0A0B1PM36_9GAMM Response regulator receiver protein OS=Halomonas hydrothermalis GN=PZ78_16320 PE=4 SV=1
-------------------------------------------------------------------------KELADSEQRYRSLFAHHPDAIFAVDPE
GRFIEANATCGRVTGIPREEVLQRH---FANFIDPDDVTHVAQQFQQVL-GGEIARFEVSLRHRDGQQRLLDVIGIPIT-VNGRVDGVYGIAQDVTASRA
QQTRLRILERSVEASVNGVLIADADLPIIYANRAFSVMTGYSLEDVIGRNCRFLQGPESDPDMVEALRCGLQNQRETHVTLCNYRKDGTPFWNDLYVAPV
RGQDGGVTHFVGVQHDISKHKAYEARLAYHATHDDLTRLPNRMHFEEALQAQFAQAQLEGHAISVLFVDLDDFKPINDSLGHAVGDQVLIEVGQRLKAAL
RQEDTVARLGGDEFVLLISSVSDKQVIDIVERLLPALARPYCIDGHELYLTASVGIAISGPTTPQPQSLIQQADMAMYKAKQQGRNAYAWFSNDINELAS
ERVILRNDLQEAIDHQNFELHYQPLFDG-AGNIVSVEALVRWRHPVKGYISPARFIPLAEATGQIVPISEWVLQRACTDMLSLQQKGLGSLKVAVNLSPL
QFHRASFLATLRQTLSSTGLPAEQLTLELTEGILMNNTEAAIGILHALRSMQVSVAIDDFGTGYSSLSYLKHLPISTIKIDRSFINELIHSDDDAAIVQG
IISMAHHLGLGVVAEGVENDAQHQRLMTYRCDMFQGFGLAKPMPLAELENIMAAF-----
>tr|S2KJN8|S2KJN8_9GAMM Uncharacterized protein OS=Halomonas anticariensis FP35 = DSM 16096 GN=L861_06670 PE=4 SV=1
-------------------------------------------------------------------------QKLWANKQRYRSLFTYHPDAVYSLDEK
GHFVSVNPAGSAITGFAESQILGKH---FSHFVEEADQARVQSIFEDAL-SGMPQRFQARTRDVQGEVHVLDVVNLPIV-INDRISGVYGIAKDITERKQ
QETQLRILQRSLEGSVNGVVIADAELPIIYTNEAFTRITGYGKDEALGHNCRFLQGPESESEAVGLIRHGLTNQQEVRTTLRNYRKDGTPFWNDLYIAPV
RDESGKVTHFVGVQNDISEHKAYEARLAYHANHDALTGLANRTLLEDRLTHDIHLTLREGRMLAVLFIDLDDVKMINDSLGHGVGDKLIIAVAKRLTEEM
RPGDTLARFGGDEFVVLLPELEHEAAMKVAEQLLATIARPYRLGVRDLYVTASIGLAFSSDEIEHPLVLIQQANLTVSKVKKQGGNGYRLYSGEISAQAR
ERLTLRHDLQAAIEARQFEVHYQPLVRAEDGRITGFEALLRWKHPSKGYISPAVFIPLAEDTGQIIPISEWVLRQACHDLQQLG----DDYRVAVNLSPM
QFHRSDFLSTLQRTHTKTGLAPGRLELELTEGILMEDTETAIGLLRQLRDMGIKVALDDFGTGFSSLSYLKNLPIDKLKIDRSFVLDVANKRQDAGIVQG
IIDMAHHLELTVVAEGIETVEQRDTLRALGCDLLQGYLFAKPMPLAELRTFLETS-----
>tr|W7Q916|W7Q916_9GAMM Uncharacterized protein OS=Halomonas sp. BC04 GN=Q427_33410 PE=4 SV=1
----------------------------------------------------------------------------WESEQRYRSLFAYNPDAVFSIDPQ
GKFVTANPTCALITGLPIERIVGTH---FSQLVLTGEVERVQAHIVNTL-RGETQRFEVAIVSQVSNPCLLYVTCLPIL-VDGVTQGVFGIAKDVTEQHR
TETRLRVLERSVEASINGILIADADCPITYANTAFQALTGYREEELIGRNCRLLQGEETDRETVALLRSRLAEQRDCHVTLRNYRKDGSAFWNALYVSPV
PNADGRVTHFVGVLNDVSERQAYEDRLTHSASHDALTGLANRGLLEDRLIHHFALSQRQGCTMAVLFVDLDDFKPINDSLGHAIGDRVLVEVASRLGSVM
RPGDTLGRLGGDEFVALLPDTPHVQ-AEMAKRLLKLVARPYRIDHHELHLSASIGIAVSSDAIEQPMELIQQADMAMYRAKKQGRNAYQWFTRDITSRVN
ERLVMRNELQDAIDGQRLELYYQPLYDS-AHQVASVEALLRWPHPTRGFVPPSEFIPLAEETGQIMPISRWVLERACLDMRLLDTQGLEGFKVAVNLSPV
QFHRAGFLETLRETLARLSFPANRLELELTEGVLFNDAEEAVEILHALRRMGVDVSIDDFGTGFSSLNYLKHLPISKVKIDRSFVSEVTHSADDASIVQA
IISMAHHLGLVVVAEGIETAEQHSLLKEYGCELFQGFLLARPMPLAQLEVLLRAG-----
>tr|A0A0D5M9S0|A0A0D5M9S0_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halomonas sp. KO116 GN=KO116_04095 PE=4 SV=1
-------------------------------------------------------------------------RELAESEQRYRSLFTYHPDAVFSLDSE
GRFVTANASCVNITGYTQSEILDQH---FTHFINADDKERVDQHFAIAI-QEKITRFDLSILDRNGESHLLDVIALPIS-INNNVVGIYGIAQDVTISRA
QQTQLRTLERSVEASVNGVLIADANMPILYANKAFTTMTGYTQEDVIGQNCRFLQGSGSDPAIVAKIRLHLAEQRDVHVTLCNYRKDGTPFWNDLYISPV
RDQEGRVTHFVGVQHDISKHKAYEARLAYHASHDDLTRLPNRALFEEKLLAQFTLLQQGEQRLAVLFVDLDDFKPINDNLGHAVGDRVLIEVARRLQASV
ESNDTVARLGGDEFVMLLTNITEAQIVERVECMLTTLARPYCLDGQELYLTASIGIALSQDTTLQPQMLIQQADMAMYKAKQQGRNAYEWFTEAFTDSVS
ERMVLRNELQEAIEREAFQLHYQPLIDQ-RGQLAGVEALLRWQHPSKGWISPSRFIPLAEATGQIIPISEWVLKRACLDMQALTLGGLGPVQVAVNLSPL
QFNRASFLTTLRQTLLDTGLPPEQLSLELTEGILMDNTEAAIDTLQALRSMQISVSIDDFGTGFSSLSYLKLLPISTVKIDRSFIRELTHSGDDAAIVQG
IISMAHHLGLRVVAEGVETEEQHLRLMSYQCDIFQGFGLAKPMPIEALKNFIASL-----
>tr|W1N8D2|W1N8D2_9GAMM Uncharacterized protein OS=Halomonas sp. BJGMM-B45 GN=BJB45_11595 PE=4 SV=1
-------------------------------------------------------------------------F--EVREQQYRSLFSHSSAAVFHVLPD
GTVREVNAVAEALLEEKVDDIAGME---FSALACRSLSAELLHTWRTAI-SGGRGC--CCRVAGRGSARCYNVRMVPIV-VDDSIVGVFAVFEDVSAWTE
TLVRLTIMERCLEESSNGVVILDAGNPVLYSNVAFREMTGYRSSQLTGKTLFLLAEGGTIVPELVRLHRAMAEHRPCSVTTQARCRNGDTFWCQISLSPV
RDEDAVLTHYVAIIDDISLRRQHEQRLAYQATHDALTGLINRTMLAERLSHAIRQARCQPGILAVLFIDLDEFKSVNDSLGHEVGDRLLVSVARRLEQEL
RDSDSLARMGGDEFVLILAGLENEAVERVALRLLGALERPHMMDGWQLHVTASIGIAELSETAESPGLLMQRADIAMYRAKQKGRNQYQRFSEVFDEKLH
RRLTLRNELRIAMDQHDLQLYYQPVINQ-SGHICGCEALLRWLHADLGWVSPEDFITIAEQTGQIVELGRWVLWRACNDAQCLVQSRLMPGRVAVNLSPL
QFYRSDFLADLGSVLEEVGLDAHWLELELTEGTLMRDTRSSIDTLNSLAEMGITTAIDDFGKGCSSLDYLQRLPVTRIKLDKSFVHAIDHGDCNAAVCKS
VIVLGRELELEVLAEGVETRAQYECLLGLGCEKFQGYLFARPMPFSALCKLLQDG-----
>tr|A0A099KRN2|A0A099KRN2_COLPS Diguanylate cyclase/phosphodiesterase with PAS/PAC and integral membrane sensor(S) OS=Colwellia psychrerythraea GN=ND2E_2344 PE
----------------------------------------------------------------------------EEISSRLRAIIDNSPIGIWFTGID
GRYHFVNKTFCNLAGIEEEDMLNTPSANL-ALLLGDEIAHLNSDRAAQDFPHVSYE---TIPRLNAKPYILEVTKVKLKNSHGEVIGLIGISKDITNKRQ
QEEDLKLADIVYQNSSEAMMITNANNEIIAINPALTEITGYSSSELIGKNPSIFSSGKQSTEFYQSMWEELKLTGTWQGEIWNTKKNGGEFPEWLSINTI
YDDYGNVFRRIALFSDITEKKKKDALILRQAKYDSLTNLPNRIMFIDRLEQEIKVSQRKMQKFALIFIDLDNFKKINDTRGHVYGDTLLIEAGKRITHCI
REVDSVARLGGDEFTILLSDIADHNVEIIAQKVLDALSKPFYISKMYTYISASLGVTIYPNDASSTLELLKNADQAMYLAKNLGRNRFCYFTASMQEQAL
EHLELMDDLREAITLNQLTVFYQPIVDLKTGEIRKAEALLRWKHPIRGMVSPAEFIPLAEESGLIIEIGDWVFKQTVQHIKKCKEQLGLDIQVSVNKSPV
QFRESIEQLDWLSYLAENQLPGENIVIEITEGLLMNNNISTLERLSKFRAAGIGLSMDDFGTGYSSLSYLKKFALDYLK---------------------
------------------------------------------------------------
>tr|Q485A5|Q485A5_COLP3 Sensory box sensor/GGDEF/EAL domain protein OS=Colwellia psychrerythraea (strain 34H / ATCC BAA-681) GN=CPS_1622 PE=4 SV=1
----------------------------------------------------------------------------EEISTRLLAIIDNSPIGIWFTGTD
GRYHFVNKTFCNLVGIEEEDMLNTPSSNL-AELLGSEIAHLDSDRAAQDLAHVSYE---TIPRLNAKPYLLEITKVKLKNTRGKVVGLIGISKDITNKRQ
QEDDLKLADIVYQNSSEAMMITNINNEIIAINPALSDITGYSTSELIGKDPKIFSSGKQSLQFYQSMWEEIKRTGTWQGEIWNTRKNGDEYPEWLSINTI
YDDDGKVFRRIALFSDITEKKKKDALILRQANYDSLTNLPNRRMFIDRLEQEIKVSHRKKQKFALIFIDLDNFKNINDTRGHVFGDQLLTEAGKRITHCV
REVDTVARLGGDEFTILLSDLSEYNVESICQKVLLALSQPFCISKLYTYISASLGVTIYPNDASTTLELLKNADQAMYLAKDLGRNQFCYFTASMQEQAQ
NKLELMNDLRTAISLNQLAVFYQPIIELQTGIIRKAEALLRWKHPVRGMVSPAEFIPLAEESGLIIEIGDWVFKQTVQHIKECKKQLGLDIQISINKSPV
QFRETVSQLDWLTYLTENQLSGKNIVIEITEGLLMNNNTSTMEKLSRLRAADIKLSMDDFGTGYSSLSYLKKFELDYLK---------------------
------------------------------------------------------------
>tr|G3IST5|G3IST5_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_1223 PE=4 SV=1
----------------------------------------------------------------------------KASETRLRSIIDASPVPMVLNDDQ
QNITFLNPAFIQTFGYTLEDIPTLTDPEQ-KVLEREARYRTYSASDATTETEVSGQPLLLMPRKDGSEFPLELSLAKWEAS--EGWFVTGIIRDITERKQ
AEADLRIAAIAFE-TQEAMMITDTHQVILKVNQAFVRITGYSAEEAIGQTPALLKSGYQDAKFYQTMWESLVRDGYWQSEIWNRRKCGDVYPERITITAV
TNAEGNVVNYVGTFDDISQHKKAEETIHDLVFYDSLTKLPNRRLLLERLKHSIEVERRDGKQLALMMLDLDRFKVINDSLGYLAGDELLQQVATRIATRL
RKVDLLAHLGGDEFIMLLEDITHEDAARVAEQVIAILSKPFYLSQDEIHITASVGISLYPQHGDNPDTLISYADAALNKAKAEGRGCFAYYSEDLTLAAR
QRIALEARLRKAIEQQELRVFYQPQVDIVTGRIIGAEALVRWLDPIEGLIAPIHFIPLAEETGLILEIGAWVLRETCRQGRQWLDAGLPPLTLAVNVSAH
QFRRSDGAL-VTTVLNETGFPAEQLELEMTESGLMESQSKVMGLLNDLRSQGVRFAIDDFGTGYSSLAYLKHFPLDSLK---------------------
------------------------------------------------------------
>tr|E4U769|E4U769_OCEP5 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Oceanithermus profundus (strain DSM 14977 / NBRC 100410
---------------------------------------------------------------------RRLLPPFHLTPGEWAILSRRLPVVVYQADEQ
GTTLFAAGAIESMLGYTAAEWVGRPDAWY-ASLHPDDRAKVMRLAPADATPEHGDQTRVRFRLESGEYHWIALHGRR---AAGDPEVYLGYLMDVEEKAR
HEQWSRMNAAILEPDYVSIMEHDPENRRM-VVRAGKRVPVGTTFE-------LDRSQAGF-T-QKLNEVVV--AHDLRNRFPVPERLLEWGIRSTLSVPI
PGDENTVRFVQQVAQLMGRYRKVMDDLEFKAYHDDLTGLPNRRALYRHLSYLLSN---AEVSGAVAFLDLVDFGEVNDTWGHETGDRLLRYVGSRLQALA
PVGVWAARWGGDEFVVVLVGDDPRA---LLEQALEHLSASTPLGEHRIRLSARAGMVRFRTFGSDAETLLRRADMALAVAKESKREVY-EYEAGLQEKAA
ERRARVEALRRAMEGGELYLHFQPVVNPEGRYVVAAEALLRWRDPRTGEISPAEFVPLAEQYGLAVKLDARVLRMALDEGLRWLEWGEAAPRLSVNVSPE
SILDPAFTASLEELLQSTAYPPERLTLEITERI-IADVEHTRGPLTHLRELGVRIAVDDFGTGYSSLAYLAYLAVDILKVDRAFTRDIGKNPRTEAVLRS
IFALGGNLGLQITIEGVEDVRQLEWLRRTECDWVQGFGIARPMQAQAFTRWLDD------
>tr|D5BZM0|D5BZM0_NITHN Diguanylate cyclase OS=Nitrosococcus halophilus (strain Nc4) GN=Nhal_1148 PE=4 SV=1
---------------------------------------------------------------------NKKAQASKVAQARLQHLLTVGPAIIYSLRAP
YATTFISDNIQAQMGYRPKDFIDTPDFWL-NRVHPEDRDRVL-----------KLYYEYRLQHRDGHYRWIHNGQHLVRAADGQPLEIVGYWIDITERKQ
AEAALKQHQTILDRIPVMIAHFDPQGQLQWLNREAEHLPRWGDLR-------I---------------------------------------HSR-----
--SDG---SRIGIGKDVTEYKAYEAQLERQTNYDTLTGLPNRNLLQDRLSHALARARRTRQWVAVLGLGLDHFKLINDSLGHSAGDALLQAVASRLEACL
REGDTAARLGGDEFVLVLEDLPEKTGVPTIQRILNTLEAPFQLETQEFFISASIGVSFFPQDGRKARTLLKQADIALHRAKNQGRRGLQYYTPAMSMETI
RRLSLENSLRSALDRGELKLHYQPQVSLENGRVMGVEALLRWQHPHRGWISPAQFIPLAEENGLIVPIGEWVLNTACAQAKTWQVTGEPPLTIAVNLSAR
QFLQTKFIAQIDQILGQCGLAAKVLKLEITESLLMQDLKGAITTLHALKERGIQLAIDDFGTGYSSLNYLKRFPLDQLKIDRAFIRDITREPDDAAIAQA
IIALAHSLKLEVMAEGVEREAQVAFLQAKRCHAIQGYYVSRPLPPEQLAPWVRE------
>tr|D5C504|D5C504_NITHN Diguanylate cyclase OS=Nitrosococcus halophilus (strain Nc4) GN=Nhal_2128 PE=4 SV=1
---------------------------------------------------------------------RQAQEFLEITRARLEHLLTASPAVIYCVGGN
YVNTFVSENVQALVGYKPKDFIEDSCFWI-NHVHPRDQERVA-----------KACYEYRFRHQDGSYLWIHDELQLVRDADGQPLEIVGYWVDITDRKR
VEQRQ----VILEASTDFVGFSDNEGIAQYVNQAGCRLPDWANII-------IQNEGLPA-A-KRQGW--------------WRGE---TALLHR-----
--SEGEVEFFSTVARDISEHKAYESQLEYQANYDSLTGLPNRNLLQDRLEHAIAHARRIRQGVAVLFLDLDRFKMVNDSLGHDVGDALLKAVAERLRGCV
RDEDTVSRLGGDEFVLVLEELRGGEMSLIANKILAALQAPFALEGQTFRINASVGISLFSRDGKDALTLLKSADTALHWAKAQGRGCIRSYTSEMNAQVV
ERLTMEQSLRQALEREEFVLQYQPIMDLQTGSMVAVEALLRWQHPQLGVVPPAKFIPLAEELGIMPTVGEWVLRTACLQARRWQDAGLPMLTMSVNLSTQ
QFIQVDLTDRVAHILDETGLPPSCLAIEITESQIMQDVESAIASLRAFKEMKVHLSIDDFGTGYSSLIHLKRFPLNRLKIGKDFIHDFTKTPEDETIVLA
VISLAHSLGLKVVAEGVETEEQLRFLWENGCEEMQGHYFSRPLPASEMEVLLQE------
>tr|G4T0V1|G4T0V1_META2 Uncharacterized protein OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) GN=MEALZ_1698 PE=4
-------------------------------------------------------------------------------------------------AVD
SRMLYVSPAYETIWGHSCESLYKNPQSWM-ETVHPDDQAATYKSL--D------ANFQFRIVRHDGSIRWIEVKSYPVRDDDDSLVRIAGLAKDITEYKA
AEAKIAYLNMLSDINALIVREHD----RDNLFKEACRISSSE--K-------VQKSMVVR-A-IREKTAVV--SNDSQNKVLLCGKYAEFGVHSMAILPL
IVREEEMALLTELAGDIADHIAKQERLDYLAYYDELTGLANRRLFLERVEQYMSSAIGGEHKLAVLLIDLERFKNINDSLGQLGGDALLKQVAAWLTQNA
GEARLIARMGADHFAVVLPKVTQDVDVLIEKTLTTFQEHQFHLHDAVFRIAIKIGATLFPDDGARADILVRNAEAALKKAKTSGFPYL-FYTQKMTEAMA
HKLSLENQLRQALDNEEFVLHYQPKVNLASGKLTSAEALIRWNDPRTGLVPPARFIPILEETGLINDVGRWALHKAIDDYLRWHNAGLAAVRVAVNVSPL
QLRDRGFSGQILQAIDIHEQAPSGLELEITESLIMADVKHSIASLQTIRAMGISIAIDDFGTGFSSLSYLSKLPVDTLKIDRSFVIEMTESSEGLLLVST
IINLAHSLKLKVVAEGVETEEQASMLRRLHCDEMQGYLFSKPVPGEIFETRFLS------
>tr|A0A091APX5|A0A091APX5_9GAMM Uncharacterized protein OS=Arenimonas oryziterrae DSM 21050 = YC6267 GN=N789_03870 PE=4 SV=1
---------------------------------------------------------------------RRAMQLLRESERRFSDMLGN--MHLASLDRE
ARITYCNPYLLRLTGWTLAE--VLGRDWF-ETFMPAELGDRKALLESDH--GHIVPLRFRDAHRRGMAHYLATGEGPVLIGETATPMFTGFIRDITQRRE
AERRLQRLNVLSGINALTVRVHE----RSELFRDACRIPLREDAT-------GANTAVAQ-A-VRQRRTIV--SNELRNRVMLAHEPFAAGAHSRIVLPL
LVDSEELALLTGLADDIAGHIERGERLAYLARYDELTGLGNQASFLERLQQKIHATGDSEVKTAVFVVDIERFKEINDALGRKTGDEVLRQLAARFGRLD
GEGHRFARISGDRFAIYAPGMGNVEQVYVEERMAKVFSPSFHVGGNELHVSIKLGIAIYPDDGSDADEVLRHAEAALKKAKATGNRYL-FFAHKMTERVA
ERLSLEGRLRQALERNEFVLYYQPKINLVNGALTGGEALIRWNDPQTGLVPPGLFIPVLEETGLIFDVGRWAMHKAIEDYLRWLNAGLASVRIAVNVSPL
QLRSRSFVEEVRQALSVDPRAAAGLELEITESLVMEDVAHNIAILQAVRDMGVTIAVDDFGTGFSSLSYLSKLPMDTLKIDRMFVNDMTATPQGEALVST
IVNMAHSFQHKVVAEGVETEAQRQILRRLGCDEMQGFLVSRPLPGDTFASSFLL------
>tr|C8S3Z3|C8S3Z3_9RHOB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodobacter sp. SW2 GN=Rsw2DRAFT_2771 PE=4 SV=1
---------------------------------------------------------------------NQTLRETLQLQRRFRLALDAAGGGVWETHGG
GESVHLSGRLAEQIGLNSEMDFR-HAELR-KLVHPEDLPTFDSTIEDRWTKEELFSNELRMRHRLGHWVWVLSRGRVTRSASGEPVIMSGVHGDISARKS
LEKDLQNERRLTETSISGILALDGDGVVLFVNKEAEAIPSWKITA-------PDGSPLEH-D-FPFVRAVE--QGIAFRRLRIVRPDGRNRIISVNVAPI
LD-------VTDITAQAESLARAAEAAQYAALHDQMTGLPNRELFREYLEAAIRLANSNTIELMLVFMDIDNFKQINDTYGHFNGDKLLLELSHRIASHQ
NTSDTMARIGGDEFTFLHQLQSGESAAEVLDPLVQELERPFLIDGGQVYLTVSFGVSIFRRDANDADEMLRNADLAMYQAKGNGRNQHVVFSSSLRAQMS
QQAKVTQALQRALRDKTFSLVLQPKFSLNPARVSGAEALLRCNDPLLQSIGPGEFIPVAEQAGLVRSIDLCVVDMLGGIKAAWKQ-QGIDLRVSINLSSE
SLRWSGFGDALVRRFHENRIGPDDVLIELTESALMDMSPTSKANMGSILAEGFDISADDFGTGYSSLSYLHLIQLRELKIDRSFIARLGAGVASDSIVRA
ILAMARALGLRTVAEGVETEAQREWLQDQGCDEVQGFLFGAGMSVDAFTANFMM------
>tr|D5AMJ4|D5AMJ4_RHOCB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
---------------------------------------------------------------------ETAFEAVSQAEDRLRGALDAAGGCDWEDRHG
VLWLRTSGILARRIGWREGEAVP-TTELR-ALIHPDDMESFNLHFADRWKPEDFFTEEFRMRHADGHWVWILSRGRAVEAATGEALVLSGVHVDISRRKL
LEAELIAKNRLTETSVSGILAFDPSGVIVFANMEAEQILGWLYGP-------REGTGAGR-G-FPFERVAQ--GGETLNRLTLPRPDGTERVISVNAAPM
ES-------VSDITQRLMRLAQAAEEASHAATHDALTGLPNRESFRAQVGPAQLRARPAGDLLQQVFLSIDQFQQIKDRFGPQLGDRVICKVAERLEALR
EPDQLLARVGAEEFTFLSRGRLAEEPEAATAALAQAFAEPFEIDGQPLYLSASMGMSLFPMDAHSPEEMWLNADLAMYEAKALGGNRAVPFTPKLRDRLA
QEAMIGQSLQRAIRDGAFALYLQPKINLLHGSLAGAEALVRCTDPALAGIGPDIFMPIAEKTGLVRDIDLLMIDLVGAFVATLRG-RGQQLCISINLSPE
SLRRVRFGQAVLAHLAAAGLGPEDVLFEITEGAVVDLNSDARESIEALLAAGFELSADDFGTGYSSLSYLQKLQLKELKIDRSFVSRIALGDASDAIVRA
TLAMAAALGLRTVAEGIDTPAQVVWLRQHGCDLGQGYHFAKPLPAMDFMSGFLE------
>tr|V4ISG3|V4ISG3_9GAMM Uncharacterized protein OS=uncultured Thiohalocapsa sp. PB-PSB1 GN=N838_15985 PE=4 SV=1
------------------------------------------------------------------RRVAERTAELAASEQRYRGIVEDTPSMICRFRAD
GTIDYVNRAYCDYFRVARENLVGRN---FLGLL-PKSE--RRQVMANTLVEQPMQTHEHQVAMPDKGVGWHRWTNRGIFDTSGGLIAYQAIGEDITERRK
AEDKLRQSAAVFSSTAEGVLITDLDGTVIDINKAFSNITGYAPDEIIGENPRKLKSGQHDLSFYQAMWQSLIETGNWSGEIWNRRKDGSVYPGLFNISTV
RDPNGQAEGYVGVFADITALKQTEQRLERLAHYDPLTDLPNRLLLTARLERAIKHAARQAGKIAVVFVDLDRFKTINDSLGHPAGDRLLAELAQRLAAVV
RSDDTVARLGGDEFIVLLEDIDGADHVRVVEKLMGVFKDPFDLDGNEVHVTASLGLSLYPQDGTETATLLRNADSAMYRAKEDGRNTYKFYTEELTNAAF
QHMFIENALRGALQNEEFRLVFQPQVDLATGHLTGIETLLRWQHPMQGDIPPGLFIPIAEHSGLIQEIGDWVLVAACRQGREWLDRGLHIGRIAVNVAGP
QIQQTDFVMRVISTIKEIGFPPEYLELEVTESFVMRRREDSVGQLQAIRDLGIAIAIDDFGTGYSSLSYLKQLPIDKLKIDQSFVRDIPADANDQAIAEA
VIALGKALDKEVIAEGVETAEQAEFLKSKGCAQAQGYFFGRPVPAEDMESMLRAYA----
>tr|T0BRT1|T0BRT1_9BACL Uncharacterized protein OS=Alicyclobacillus acidoterrestris ATCC 49025 GN=N007_13680 PE=4 SV=1
--------------------------------------------------------QLQCVVV-CAQTERRIEAQLHRSQQVYNSLFACNADAVFALDLN
GRFIEVNEACVRVSGYTQETLLGMP---FQVLVAPQELDAIRRFML--ACQGEAGEQDVTIIHRGGERLTLNITTVPIVVD-EEIVGIYGIAKDITALRY
KEKLLLAQMSVSKEIAAGDMLVSEEGGLLPAASSDSAMSGIPIGPNSSSDLVITTDIARDSDKYRALAEAEGLQSCF-------------------AIPI
LSDDQQVVGTFELAGLAISRHQNASKLHALANTDPLTGLPNRRYFMNHLRQA----AQAGEPVGLIFLDLDRFKWINDTLGHAFGDKVLTEYARRVSDCL
DRRVLFSRLGGDEFAVIVPDVRTKDVMRVAQQILRLSDKLIHIDGHSLRVTASIGTYLSTEAERDVEALLSNVDTALYTAKNSGRNNIKPFDPHMRFVTY
DHLVMESDIQNAIDENQFYMVYQPKFDALTRSMTGLEALIRWRHPRSAMISPGDFIPVAEQAGLISAVDDWVLREVCRQIRVWEKAGLQ-VPVSVNISQI
HFQQLDFTDWLRRTIESYDVNPKLIDIEITETALMQDEDHILAKLQELREIGVSLSIDDFGVGHSSLNLLRTFPVDFLKIDQSFVRDHEK----PDIVTA
IIQLGHSLGMQVVAEGVETPYELEFLTTQGCDEIQGFLLAKPMSPDDIATKLSN------
>tr|A0A094NPP4|A0A094NPP4_COBMA Uncharacterized protein OS=Cobetia marina GN=KP05_16550 PE=4 SV=1
----------------------------------------------------------------------SRPANGQEAEGLLNQLLDHTSNGVCCYGLE
GRIRWVNPAFEKLLGYREQQVIGKV---PSEFLMPASDLLITRLREQ-RRGEPSD-EELVHYDSNGRPLRLRLRCIPLKDSRGRVEGYLGLQTDITQMHR
ALMLSHSQLELLEAVAAG-LLLDDEGRIVAG-EGPLFTRGLKIGEGVGTKPVMTPSIAQEPEGFREHPHALGLDACL-------------------SMPI
LDGDDNPLGSFAVARLAIERYRRDQQLTHQALHDSLTGLPNRRLVRRHLCELAEQA-QPGEMGALMFLDLDHFKRLNDILGHDAGDLALKQVASRLAEML
GPQDFLARHGGDEFIVLLAPRAGPRARQVAEQMLERLQEPLELEGRTHQLTGSLGITLYPRHEDAWSHLLHQADIALYESKGAGRARLCFFAPEMRQRII
DAARMEHALREAVSRQQLSVHLQPQFSLPEPQLCGAEALLRWHDPQLGMVSPATFIPIAEESGLILELGHWVLEQVCRELAAMTARGYA-LPMAVNVSQV
QFRSSEFVPQVTRLLAQHDFAPELLRMEITESLATDDEAAMLEKIDQLAALGLSFSIDDFGIGYSNLSRLRRMPLKELKIDRSFINDLSHEETGNEIVRA
MLMMASALSLDVVAEGVEETEQLEVLRRMGCSRVQGYLLGRPRPMAEVIGNAE-------
>tr|B1XYS1|B1XYS1_LEPCP Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP
--------------------------------------------------------DDPPASGRTGSTPR---TDRSALLPALTRLFDDGPCAALVCGAD
GRITEVSDSCGRWLGLAAADLLGRR---PEQVLAPGATIPWERLQDQ-ARHGRAG-TEALVHGHGGRPLWCTLVLDALPAAQGEPDTWLLTLADITQQRI
---LTELQGPVLGALVRD-LGVDDDGLIRPL-AGPCQFDGAPIGPKAGSSPVVVTDIDTDPDDYRHVVQPLGLRACW-------------------SSPI
KNGEGRVLATFALCTLALERERSHAHIHQLAYYDGLTGLPNRALLQANLARAITQAQQDGTTLALLFIDLDRFKDVNDSHGHAVGDELLREVAQRLAGEV
RDRSLVCRLAGDEFVVVLPHCGV-QARHTAERVQQALARPITVGDLDLTTGACLGVAMYPDDGSDLDRLLRHADAAMYQAKKDGRGGLHFYRAEMNRAAE
DRLRLAADLRAALHRGGLQLHFQPQVCPPGMSLFGVEALLRWRHPVLGDVSPERFIPVAEEAGLMDELSNWVLEAACAQLAGWRADGID-VRVAVNLSPR
NFQDPGLPARVRQLLDRHGLRGDQLTLELTESAWIDRRADSLDKLRALQALGVGLAMDDFGNGQSSLSHLHRLPLRQLKLDRSFVHDIEHLAVAQTLAAA
MLHIGESLGLIVVAEGIETAAQAAFLIEHGCPVLQGDRYAQSMAAEQIGPWLAG------
>tr|E8RR41|E8RR41_ASTEC Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Asticcacaulis excentricus (strain ATCC 15261 / DSM 4724
----------------------------------------------------------YVFLHMTGSTPFYLEGDATELMQLKGKAVDAIDTAMVITDTS
GRFLYVNAAFRNLLGFSASELIGKT---LGDLCQHSDSCELEDILTE-VHNGQRS-GELLVHNRHGHPMWVSFSATIMADD-AHRRRVIAIVSDITYAKL
---NETLQRLVFDAMMQD-LRVA-DGKLNAL-AAPAAIGGLAIGPVVGSEPVMVNDMRTDPAPYQALAVPLGYTACW-------------------STPF
KDKAGKVIGTFALCTLAFEKDAFQARIQYLAHHDSLTGLPNRGFYQTRLAEEAARATRQKTQLALHLIDLDRFKEVNDTMGHMVGDEVLITVAETLRDLA
SPDDVLARLGGDEFVFLQVGVTQAQAEAKAEALVKALQMHAQFGPQAPDVGASLGFALYPDEGPTLDRLTRHADMALYKAKTDGRGCWRAFDATMAEALR
RRRRLEADLRDALAHGGLSLVYQPQFCLNLNRFIGYEALVRWTHPELGAIPPCDFIPVAEEAGLITALGQWILSRALETAATWPAH-----NLAVNLSPL
QICEGDLTRYVQQELVRTGFRPQRLELEVTEGVLIENTDRALHVLRQLKGMGVRIAMDDFGTGYSSLSYLQTFPFDLIKIDRSFVEGLTPSPPAEAIVRA
VIGMAHAINIPVIAEGVETQEQMDLLRDMGADAVQGYLIGRPQAY------CLS------
>tr|A1WTF5|A1WTF5_HALHL Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Halorhodospira halophila (strain DSM 244 / SL1) GN=Hhal
--------------------------------------------------------LLYLLLRRLARRERF--RSFETLAE-------HIPDVLVRLDNQ
LRYLYVNPAFEALTGVDRREALGRC---QEEVGY-PPPSPWQALLER-VRCGQPETLSFEFTDVRGQTCSLQARLVPEFDAGGQVVSMLALVRDLTELNR
AHQRV---SQLVRLYAA--IGLVDAETQVVP-QAW----GVAYLEGRGPRPVVFEDFLGARAPWRAAATQAGFGAVA-------------------AFPL
RHGG-EPVGALALAEDVGFALDHSAQLQYLAEHDLTTGLPNRSWLLGRVAQGIR-RASDSERFAVAFVDLDRFKVVNDSLGHDAGDQLLRQVAERLGEMV
RSGDEVGRHGGDEFLMLLHDLESEQVAQLVQRVLNRFRKPLRIDGREVAVTPSVGLSVYPGDAADADGMVRAADTAMHRAKDEGGNRYRFFTEEMNREVR
QRVELEAMLRNAEQRNELELWYQPQVALSTGQVVGVEALLRWHHPDRGWISPGEFIPVAEESGLIGAIGEWVIGRACDQAAEWRGRGVL-QPVAINLSAA
QLRGTGLPAVIQRALGRRSLPAEALQLEMTESLFFEDDVNVRTAIAELQSRGLQLAVDDFGTGYSNLGYLKRLPLAKIKIDQSFIHGVPEEPEDCVITRA
IIHMAQGLGLRAIAEGVERPEQLELLRQLGCDEVQGYLFSPPAPAAALEARLAE------
>tr|H5WVI3|H5WVI3_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Burkholderiales bacterium JOSHI_001 GN=BurJ1DRAFT_061
----------------------------------------------------------RRFAHRPARARRA--QGTLALAQQAQALLQHSQHAALVVDTE
GHARWVNATLAAAAGVSA-----------QRAGS-PA---WSLLLGNRAVGGAPTRVLAVHQAAGRPPVQLDLDVQPWHDAAGALVGFLAVGANVSTDRA
RERRL---RLLIDNAAAGI-----QTRQLLG-RAWLARDGSTLLRHREPIPQSRS----DQRRWLRVNTQLIIDGQ------------------------
---T-NQRSVLSSQEQVQQRRQLEQQLLNAARTDRLTGLPNRTLLMERLEHAVRLRADATRGFALFFLDFDRFKLVNDSLGHEAGDLLLREISLRLRRTL
RSGDVVARFGGDEFVVLLNDAARDEAHRVSQRLLEAFAAPYFIKGKEIHSSVSIGIVMGTA-DTDAEALLRNADTAMYEAKRTGRGRAVFFDLGMHTRLA
RALTIEEALRHAVQRRQLSLVYQPIVDLETGLIVSTEALLRWQHPELGMVSPAEFIPVAEESGLILDIGEWVLREACRQWSRWQQQHPA-HPATISVNLS
RVQPERLLERVEEALAENRIPKGHLQLEVTEREVMHEPAEMRALMQRLRGLGVRLAMDDFGTGTSSLGCLRDYPFDVVKIDKSFLAGLHNSPDVMAVMHA
TVTVIENLGMTSVAEGVETPAQVALLQSIGCRFAQGYLFARPMPADALAALLPT------
>tr|B1XL77|B1XL77_SYNP2 Sensory box/GGDEF domain/EAL domain protein OS=Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) GN=SYNPCC7002_A2587 PE=4
------------------------------------------------------------FQRRA-SAYRQTSEALASERNILQGLFNSLQGALFVCDGA
GNFIRWNRFYQEVLGFSDAEMSHLK---AIETVVPEDREFQQQLLE--VFQGYAE-GEFRVRTKQGQTLRLYFASRVELDLDQNASGFTGIAIDISALKQ
VEAELRSQRSLQNCFLAHA-LL--EGA---------FEDGLLLQLNQLTKTLQ---ILDAAACFCDDSVASNAAKVL-------------------TIPL
IFHE-QQFGLLLSISLAIANAHHFKELRYQARYDSLTTIGNRNLFHDTIQEWLNAPSLGYELIIVMLIDLDRFKDLNDTLGHKLGNTFLQQIALRLLSAL
SPYQG-CRLGGDEFAVACPMMHSWHAVELADILQAAIKQPFVTAGNVIHITASLGIAMFPNHGTDSHAALRSAEVAMYAAKQK-RTAYEIYHEDIDHYTP
RRLAILSSLGKPSARQQFFLCYQPKFDLRQKRLIGVEALARWHHPTFGLISPAEFVPLAEQSDAIHALTYWIWEEAFQQKKAWQNQGLD-LAIALNLSAC
SLLDPNCLTTFESLLQQYEIIPAQVELEITETALMSDPRYALELLQCFANLGVHLSIDDFGTGYSSLSYLQRFPVHALKIDQSFVVDMLTNEQSLVIVRS
TINLAHSLGLEVVAEGVENQAILDLLKEMGCDIAQGYFLGRPQRAEQVHRFSAE------
>tr|M1NE36|M1NE36_DESSD PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Desulfocapsa sulfexigens (strain DSM 10523 / SB164P1)
------------------------------------------------------------------------------FELNLQVVFDHTDKGIIIHDQE
GRILAANLPAQHLFDCDESTMSSLT------VLDLSAEAALSQIIQ-RIQDGETLILPWRCQLADRSKFDAEIYYTPIIW-N-NEPVLMGMIEDITEKKE
QNALIHRLSTALEQSANVIVITDRDGVIEYVNPSMEEITGYSVAEVIGKTPRILKSGTHPPEFYEELWATIKAGKSWRGEICNKHKDGHFIWESTVITPI
I-ENQKITHFVAIKEDISQRKIHEQELYRQANYDKLTGLPNRNLLNTYFNDIMADFTTGSEKLVLMLMDLDDFKTVNDSLGHSVGDSLLQAVGERLKDCI
YQEDMLVRMGGDEFVIVPRHICTDHIEAMASHVLDSFIAPFDLQEQEVFITASIGIAVFPEDGETLEELLRNVDSAMYQSKNKGRNTVERYSGRLSEALN
EKLRLTAMLRRALEQKEYLLYYQPQQELATGKVECFEALLRWQPQSEAMIFPDKFIPILEETGMIVSVGEWVLREVCFQVTCWQTKGIAIQHASVNVSLR
QFQRPDIVKELLSIVTESGVDPSIICLELTESIMMDNFRENLHKLQALRTAGFSVSIDDFGTGYSSLNYLRRMQIQELKIDRSFINALSED---TTLVNA
ILGMARGLGLRIVAEGVETEEQKSFLRAHNCEFMQGYLLSRPLPAEQFEAFILSL-----
>tr|Q1K2Z8|Q1K2Z8_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_1985 PE=4 SV=1
------------------------------------------------------------------------------IAEKLQHICDNVPDLIWAKDIK
GTLICLDVYKAPFYGADGELIGTVGSA---RIITREKQMRLSRVNQ-HIVPQPIELFQFVCDLLEDTTFA-------MAW-I-GLPNEMGVYKDVHEHEQ
QQAFLQLAATVFDNSREGIVLTDKNEKIVSVNRAFSDITGYRDDEVLGQTPRILKSNRHGRDFYQNMWHCLAEHGCWQGEIWNRRKDGQVYPELMSMSAV
CDDQQEVSHYIAVFTDISQAKESQEKLDYLSWHDPLTDLPNRSLFCTHLDQAVKHAERKHHSFAVLCFDLDHFKDVNDSFGHLVGDALLRKIADRLRSCL
RESDMLARLGGDEFVLLLEDVADHRVTMMAEEILHQLQQPICLTETEVQVSVSVGIAVYPEHGRDALELLQRADSALYRAKQHGRARFAYYNEEMTEQAQ
ERVQLSFHLRQALEKKEFAVYYQPQVDLGTGQIVGAEALMRWNSPELGLVTPDRFIPLAEEIGCICSMGTWILRQVCEQGKAWLDAGYPPLTLAVNLSAV
QFAEEDIACRLKETLQETGYPAEYLELEVTESTLMHKEQQTIDLLKSLNELGVRLALDDFGTGYSSLAYLKYFPLHLLKVDKSFIDDLPADANDCKMVTA
IVQMGHGLGFDLLAEGVETVAQRDCLAQLGCDYYQGYYCSPPVPACEFAALRQSQ-----
>tr|L0DX95|L0DX95_THIND Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Thioalkalivibrio nitratireducens (strain DSM 14787 / UNIQEM 213 / ALEN2) GN=TVNIR_2007 PE=4 SV=1
----------------------------------------------------------------------GTEQRLRASESLVQMAANLARIGGWEVDLE
DERAWWSDEVCRIHEMPPGTSIRVDEGI--AFYAPEWRERIREVFTRAARDGIPYDEEMQIITASGKRRWVRAIGQPVHNPEGTIVRVQGAFQDITDRRK
IEEALRRAAMVFEHTRDGVVVTDADVRILSVNRAFTEITGYTEDEVRGRNPSVLASGHHDSAFYRKLWEQLRELGHWQGEIRDRRKNGETYAEWLTIDSV
RDDAGNVTHYVGVFTDISGIKESQERLEFLAHHDALTGLPNRVLLESRLAKALERAQRRGHRVALLYIDLDRFKAINDGLGHPVGDELLRQVPDRLHPRL
RREDTLGRAGGDEFMLLLEHMDRDEAARVARDVLALLQAPFTLPGHEVFIGASIGISLFPDDGASSSELVRNADSAMYRAKELGRNTFHFYTEELTRAAG
RRLAMETRLRRAIEHREFVLYFQPQVSVADGRTIGVEALVRWNDKEKGLVGPDEFIPVAEESGLIAPLGLWVLKEACRQLQVWRHRGLALPQVAVNFSSQ
QFLLQDVTARVSEALELSGLPPEFLELEITESLLMRQGDSAPAMLRSLKDLGVRLVIDDFGIGYSSLAYLREFPIDRLKIDQSFVRDIETDHSAREIAST
VVAMGHNLSLEVLAEGVENVRQLEILKMLECDAYQGFFASAPLPAEDLPGWLAAWPSP--
>tr|A0A081FU74|A0A081FU74_9ALTE Diguanylate cyclase OS=Marinobacterium sp. AK27 GN=ADIMK_3740 PE=4 SV=1
------------------------------------------------------------------------------RARENESMIAQLGEGVLLFDQD
QRLVRGNSAAQRLLEG---RVEAFD-----DSLVAHMALPELCRFGH-LQAG-----PAELVMESDPPRLIQASHL-VMDQPHHLVVLSEHGRDSTGR--
--QVFQMG-QMLDASEELILLLKADLTLEYINARAKELLGIRSCVEM--PVNFADLGFHLDDDLRVLMSGLTHDGARGGELLRAGKA---RSIGFVIHRL
CHYQGSLH-FEMRIRDITQYMEAEEYLNRLGENDLLRVMASRVQLARQF----ETLMAPGKRLALMVVDIDRLRMINNSLGYRAGDVAIRQFSRRLVESA
P-SALVARLSADSFVLVCDGNEAVFEQ--IEAIKANMVQPMELAGQLIKISFSTGIAYWPEHSRQFEPLLQAALVALNKI-KGMRGQVSVFEPHFADTNR
EQLNLEEYLKRAIEEKRFELWYQPIVNAANGRIEEFEALMRLRDEGGDLISPERFIPLLEESGWIMLIEPWLLRAAASAASLLSRRVPGGCCVAVNICGQ
QLLDNGFIERILRILEETACEPGWISLEVTERQFLENPERVIQVLQALRELGIRVAVDDFGTGYSSLAYVKRLPVEHLKIDREFIRELPHSEPDKAIVRS
VGRMCDGLGMRVIAEGVETKEQMQWLYNHRVFLYQGYLFARPAPLESWLSEEALA-----
>tr|C3XAQ6|C3XAQ6_OXAFO Diguanylate cyclase (GGDEF) domain protein OS=Oxalobacter formigenes OXCC13 GN=OFBG_01310 PE=4 SV=1
------------------------------------------------------------------------------REARLKSVFENIPDLVWMKNSA
GVYLACNQAYKDYVGLSDEHIIGTD-----FDIFSHDEAEL---FEE-QDK---------RILKEGKPLVIEQSGNRFFDAPVELVGVLGIGRDITRRKE
DEEKLELAALVYRNSSEAILISNADNHILAVNPAFEKITGYTAAEVIGRDPKLLSSGRQDKAFYKAMWDALDEKGYWRGELWNRRKNGESYASWLTINVV
YNEDRSVRYYVELSNDFTEKKEAEDMIWRQANFDFLTNLPNRRMLMDRMKQELVKVNQSGKKLALLFLDLDNFKDINDTLGHDAGDHLLLDVAKRLKDCV
REFDTVSRLGGDEFAIILTE---PTMEKIAHSILRSLAQPYQLGSEIAYVTGSIGITVYPDDGTDIDTLMRNADQALYAAKLAGRNRMSYFTASMQAAAQ
NRIRLANDMRIAINEHQFEMLYQPIVEIETGRIQKAEALIRWHHPVRGIISPTEFIFIAEETGQILTISDWAFGEVARELSRWREHLFPDLQISFNISPI
VFQNKNDYSDWFEVLEKLNVPGSSIVMEITEGVLIVSNTQVLDRLAEFHQYGMEVALDDFGTGYSSLSYLKKFPIDYLKIDQAFVRHIENEPKDMALCEA
IIVMAHKLDMKVIAEGVQDDGQRLLLAGAGCNYGQGYLFSEPLTAAEFEKLLESN-----
>tr|C3X4J8|C3X4J8_OXAFO Diguanylate cyclase (GGDEF) domain-containing protein OS=Oxalobacter formigenes HOxBLS GN=OFAG_01287 PE=4 SV=2
------------------------------------------------------------------------------REARLKSVFDNIPDLIWLKNTA
GVYLTCNRAFENFFDLEENRIIGTD-----AGLPTDRQADM---LRP-EGS---------RIIEEGKPEVMEQTGKRFFDAPVRLIGVLGIARDITRRKE
DEEKLQLAALVYKNSSEAILITNAKNEILAVNPAFERITGYTPAEIMGKDPKILSSGRQDKAFYKAMWDALGKKGFWRGELWNRKKNGEVYLAWLTINVV
YNEDGSVRYYVELSNDFTEKKEAEDMIWRQANFDFLTGLPNRRMLLDRLQQEIVKVNQSGKKLALLFLDLDNFKDVNDTLGHDMGDLLLVDVAGRLNECV
REIDTVSRLGGDEFAVILTE---RIAETVTQCMLRSLAQPYRLDGEIAYLSASIGMTVYPDDGTGIETLQKNADQALYAAKQAGRNRMSYFTASMQAAAQ
NRIRLANDMRIAVEEHQFEMLYQPIVELGTGKIHKAEALIRWHHPLRGIVSPAEFISIAEETGLILTISDWAFREVAREVGRWRERYYPGFQISFNISPA
LFQSKTDYSDWFDELARLKAPGSSIVMEITEGVLLVSNWQVIAQLTEFHRHGMEIALDDFGTGYSSLSYLKKFEIDYLKIDQAFVKNIENEPKDMALCEA
MIVMAHKLDMKVIAEGVQNERQRWLLAGAGCDYGQGYLFSEPLAAAEFENLLEKN-----
>tr|D9SGK8|D9SGK8_GALCS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Gallionella capsiferriformans (strain ES-2) GN=Galf_1639 PE=4 S
----------------------------------------------------------------------------------------------IGGHTQ
GQFMTADGLW-------------TF-----ASIYPASITPSSADFNA-TQNL-----DWKVVRHIPRAQLLSRP------STLIFFSSLKHARTHVRAQL
AETDLRIAATAF-ESEESMIITDSRGIILKVNQVFTATTGYTSEEAVGKTPSLLKTDRHSAEFYHEMWRQIKQTGKWQGEIWDKRKNGEIYPKLLNIYAV
KSKNGVVTHYVGSYTDLTERKMAEEKIISLAFYDTLTGLPNRRLLLDRLNYALASGLRTGKNGALLFIDLDKFKTLNDTLGHDIGDLLLKQVAHRLKACV
REIDTVARIGGDEFVVMLEDVEAAQTEVIGEKILAALRMPYQLLTNEFHSSVSIGISLFSNNGQSQDEPLKQADIAMYQAKKSGRNKLRFFDQRMQDTIS
SRANLEAELRKALANEQLQLHYQIQVDS-AHQTIGAEVLLRWIHPVNGIISPAQFVPVAEETGLILPIGLWVLETACAQLKKWQDNPAAQLILAINVSAR
QFHQNGFATEVRSVIERHDINPALLKLELTEGMLLNNLDDTIATMRSLQEFGVQFSLDDFGTGYSSLQYLKRLPLAQLKIDQSFVRDLATGYNDQAIVRT
IIAMAHSLNLNVIAEGVETEIQRQILLKNQCSHFQGYLFGKPMPIEQFESLLSSD-----
>tr|A0A0B0H6V8|A0A0B0H6V8_SOVGS PAS S-box/diguanylate cyclase domain-containing protein OS=Solemya velum gill symbiont GN=JV46_20230 PE=4 SV=1
------------------------------------------------------------------------------QEVYANHIIESTPQGIIVADTN
GQIVRVNKIVLLMFGYDEDEIHGSV-----ELLMPEKFIPDVNYLNR-KDS---------------KPRIMGEDGSEAVESPMKRYVV-ATIADITERSA
IEQELQIAATAF-DSHEAMLVTDSQGDILRVNDAFTKVTGYSREEVIGKNPNILQSGRHSADFYHDMWERINQDGCWQGEIWDRRKNGEVYPKWATITSV
SDKNGQVSNYVSIFSDISSVKKAQDQILELAYYDPLTGLPNRRRLVEYLERAMVESKRSNMFGALMFIDLDNFKIINDTLGHEQGDVLLKEVANRLTTAL
REVDIVARLGGDEFVVILHENRAQYARHIGENLIRILAKPHILEGRSYVCTGSLGITMYYGNEVSFDEIFRSSDVAMYEAKKRGRNSLRFFDPEMQASLE
KRSQMESDLRIALKKKQFVLYFQKQVDN-EGRIIGMEALVRWAHPERGMISPSEFIPVCEDSGLIVPVGHWILTESCRTLSQWQQHDSKHLKLAVNISIK
EFMQDDFVSQVNLLVDEYGVHSDRLELEITESMAHDDLDALIEKMHQLKKTGISIAMDDFGTGYSSLSYLKKLPVDIIKIDRSFVDDLGVNANNESIVKT
IAKVGESFGMDVLAEGVETEEQFRLLIEYGYKQFQGYYFGKPMTADKFEEEFQSI-----
>tr|K9PZ39|K9PZ39_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Leptolyngbya sp. PCC 7376 GN=Lepto7376_1746 PE=4 SV=1
--------------------------------------------------------------------------SALAK-HIAESLPVSYAIISEWTDSK
LQTL----AFWANGELQDN------LAYD-PVKTPCERTLAMGTYEHSVQEHFPEDIDEMNAE-----SY---LGIALKNTKGEIIGELCVAAADLERQH
SETAINRQLAAMEAAIDGIGLL-QNDAYLYVNQAYLNLFGYSHQNELLGKGQVLYSEDEAKRLKEQVFPLLKQKRAWQGEAIAIRKDGSTFAQGLSLTLT
END-----LLISVCRDISDLKKAQSQITHNALHDPLTNLPNRTLLLERLDLAIHRAKRIEHNYAVLFLDLDRFKVINDSLGHIVGDKLLMAIAQRLTKHL
RETDLVARLGGDEFLILLENFNHDDVIHIAERILVDCQTPLTINEHQIFTSISIGIALGKPEYQQAGELIRDADIAMYRAKAEGNNSYKFFDAIMHTQAL
KRLTLEADLRKAIEQEEFIVYYQPIIDLRHHELMGFEALVRWQHPERGLISPIEFIPIAEEIGFIIRLDRWVFEQSCKQLKRWHTQFPQSLKISINLSAQ
DLRQTTLIQDIDYILNTTGLPGKAITLEITESMLITDIDQTIDLLNQLTARQIQISIDDFGTGYSSLNYLHRLPVNNLKIDKSFVSKMELESRNSKVVDT
VLTLSNQLGLRTVAEGIETTPQLEHLKQLGCQFGQGYLFSKPLPAAEIEAQFFQ------
>tr|K9F115|K9F115_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Leptolyngbya sp. PCC 7375 GN=Lepto7375DRAFT_5325 PE=4
--------------------------------------------------------------------------ELLEREQFLQTVLDTFPLHIFWKDRH
SVYLGGNRNFLKNAGIQGK------TDYD-LPWTSAEA----AAYDRQVIESNTAKLGETQRKADGQSIWIETNKHPLHNLDGETIGVLGT--DVTDHKA
AKALIKQQLAAIEAAIEGISIL-QNDVYTYVNPAHLNLFGYTHPDELLGRSQLLYSSEEVRRFEQDIFPALECDRAWQGEAVATRKDGSKFPQGVSLTLM
NNG-----LVICVCRDISDLKQAQEQITHNALHDPLTGLPNRRLLLDRIELALQRSKRPQSHYAVLFLDLDRFKVVNDSLGHLVGDKLLIEVSKRLKQHL
RSTDMVARLGGDEFVILLEDVDTEDIVQVVERILADCQTPILIDEHKIFTSTSIGIAMGSEDYQEAANLIRDADIAMYRAKSETHNSYKFFDAAMYLEAM
SRLTLETDFRKAITQQEFVIHYQPIVSLKDSQLTGFEALIRWQHPDRGLLSPSEFIPMAEETNLVTGLDSWVINQTCEQLMVWKQQFPNPLKISINLSVQ
DLHRSTLLQDIDDILSVMSLTGDLMILEITESMLIEDIDQTIDLLAQLASRQIQISIDDFGTGYSSLSYLHRLPIHSLKIDRLFVGNMHLKNRNYQVIST
ILALGKQLGLTVVAEGIETPHHLQQLQKLGCDLGQGYLFSQPLTAHDVETILNS------
>tr|K9TPZ8|K9TPZ8_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Oscillatoria acuminata PCC 6304 GN=Oscil6304_4974 PE=
--------------------------------------------------------------------------ALAKSEKRFRSLVQNSSDIITILEAD
GTIRYQSPSVEKILGIGDNG-----FH----YIHPEDQAV---TYTQALEQ-PGRVVEREFRFLHASGKWVTLESVGLLEEPG-IAGFVINSRDVTERKE
QEERLRLFERAIAASSNGIVISEQDNAVVYVNPSFEKMTGYSSAEATGQNCFLQGRDHQPA--LQELRNAIRNGQDCKVTLRNYRKDGTLFWNELSLSPV
ENERGAITHYIGVQTDISDRKRTEEELIHQAYYDPLTGLPNRAFLMERLREASVRKTLQGQQLGVLFIDIDRFKRVNDSLGHAVGDMLLIAIAFRLERCL
RPQDTIARLGGDHYVILLEDVQGEQASDLAEKIHNQLKAPFTFEGHAVFITVTIGIALSSIEYEVSADLLRNADIAMYRAKRSGKARTSIFDQAMHDNAV
QLLQLENDLRRELHETCFRLVYQPIVSLFDGKIVGFEALLRWYHPQQGFISPSEFIPLAEETGSIVPLGILVLREACRQLVEWQTQFPSGLKMSVNLSGK
QFLQPDLVEHVDRILQETGLNPAFLKLEITESVLIEDTQTANQTLWQLKERKIHLSLDDFGTGYSSLSHLAQFPIDTLKIDKSFVQRIGTEGKNLEIIQA
IVTLAHGLGMDITAEGVETPEQLAELKSLGSEDGQGYFFSKPLSAEKASLLLRQ------
>tr|F5UP20|F5UP20_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Microcoleus vaginatus FGP-2 GN=MicvaDRAFT_0297 PE=4 SV=1
--------------------------------------------------------------------------ALLESEYRYYTLAKILPVGIFRADAA
GDCLYVNERFLEMAGIG--------EGWA-QSLHPEDRER---VLYRAVTDKLPCKLEYRFCKGD-FTTWVFWQAVPEMTKSGEVLGYLVTLTDITDRKQ
AEFALQQAEEKYENAIEGIF--QPDGRYLSANPALARIYGYESAAELIANIDIDRQLLDPNRRVEFLRAIEKHGFVSEFESQVYRADGTTIWVSENGRAV
RDPDGNLLYYEGTVEDITLRKIAEDKLVHDALHDMLTGLPNRALFMDRLGHAIALSKRRPILFAVLFIDLDRFKVVNDSLGHLVGDRLLIAIAQRLGICL
RAGDTVARLGGDEFAILLENIKSDDAIVIAERVQAELAEPFYLNEYQVFTSASIGIVCSGFLYDRPEELLRDADAAMYHAKGLGKARHEVFDLSMHTRAV
ALLQLENDLRRALDSQEFQLYYQPIVSLISGKISGFEALLRWYHPQRGVVSPGEFILVAEETRLIIPMGWWMMRSACRQIHEWHQKFPAPLTVSVNLSNQ
QFKQPDLIDRIREILQETQLDPRSLKLEITEGVIMENAESAVAILAELKNLEIQLYIDDFGTGYSSLSRLHTFPTDALKIDRAFVSRMTEDEGNEAIVQT
ILILASHLGMDVIAEGIETSEQLNLLRALQCEYGQGYFFSKPIDSMAATLLIES------
>tr|B4VY11|B4VY11_9CYAN PAS fold family OS=Coleofasciculus chthonoplastes PCC 7420 GN=MC7420_4357 PE=4 SV=1
--------------------------------------------------------------------------ALRQSEEKLDSILRSLDDVVWSAEN-
QQFIYLNPATERVYG-VDCP-----SLWQ-FVIHPDDRQR---VENRMM-HQGSKDLEYRVVRPDGEVRWLRDRARLIYDHRGIAIRMDGIATDMTKRKQ
AEAALLKSEEQFELAPIGMA--MLEGQFLKVNQALCDALGYTAQELLALTFEISHPTRALH-FTQHQSLLQGELSHLQTERRLISKSGRIVNAILKVVLV
RDAQGQPLHYISQVVDISDRKRMEEQLLHDAFHDVLTGLPNRALFMDRLEYALRRAGQRWYLCAVIVLDLDRFKVINDSLGHLVGDRLLSAIAERLQGCL
RPSDTLARLGGDEFTILLDDIPNAAATDIAKSIHQTLESSFNLDGYEVFATASIGIALSGMGYHRAEDLLRDADTAMHRAKLQGTACYVMFDTAMSGRAL
AQLRLETELRWAIERQELEVYYQPIISLGTGKITGFEALVRWQHPEQGMISPGAFIPLAEETGLIIPIGQWVLRTSCYQLRQWQQQFPHPLTMSVNLSGK
QFSQTNLIEQIAQIIQETEVNPSTLKLEITESGIMEHSDSASALLERLKALNIQLYIDDFGTGYSSLSRLHQFPIDALKIDRSFVSRMGDAGENGEIVQA
IVTLAHNLGMDVVAEGIETNMQLAQLRGRRCEYGQGYFFSKPLNRQAAEQLMMN------
>tr|K9WKX2|K9WKX2_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Microcoleus sp. PCC 7113 GN=Mic7113_4789 PE=4 SV=1
--------------------------------------------------------------------------ALRESQRRLASLIDALPGIVFSCDPA
WSMTYLSEGCLSLTGIGNRS-----VSFD-AITHPEDLPQ---VLDTGVAQKQPYVVEYRIRTKSGQEKWLWEKGHGVFDDTGELLGIEGFITDITERKC
AEDALRQAEAKYENASEGIF--QAKGHYLSANPALARLYGYSSPAELMERLDIEHQLVEPNQRTEFIRLLQENDAVLEFESQVYRKDGSVIWIAENARAV
RDTNTGLLYYEGTVEDISERKRAKEQLRERAFYDPLTGLPNRALFMDRLSQRVERAKRHPYRFAVLFLDLDRFKVVNDSLGHLIGDQLLVAIAHRLTNCL
RAEDTVARLGGDEFTILLEDIQDNQVIHVAERIQQALKAPLNLDGHEVFSAASIGIVLSREDYDRPEDLLRDADTALYRAKALGKARYEVFDLTMHQKAV
ALLELETDLRRAVEHQEFQLHYQPIVSLLTHKITGFEALLRWQHPTRGLLYPAEFISIAEETGLIIPLGWWTLREACRQLRQWQEALQVPLIIHVNFSSK
QFLQPDAFNQIKQILQETGLEGCYLRLEITESCLLENPEASAALAQQLRTQQIGLCIDDFGTGYSSLSYLHQFPIKTIKIDRSFVSRIGAVESDSQIART
IVMLAHNLEMEVIAEGVETAQQLSQLQALNCQYGQGYLFSQPQDALTTSLLFRL------
>tr|S6GCK1|S6GCK1_9GAMM Uncharacterized protein OS=Osedax symbiont Rs2 GN=OFPI_41380 PE=4 SV=1
-----------------------------------------------------------------------SRDKLEKTKAHLHNITRSLPVAIVQLKLL
PIISYFNQGLLNIFDHQQGSDH--DFQLFWQLLNPITRRRLLRSYLKNNLTNSSYNQEFYLRDTQAKKKWFHLSATIERTASEKEISLNCMLFETTKEHA
DREKIDLACIAFNSTDEGILITDQQHNIIDLNPAYLRISGYRKTDLIGNNSSTICPWQRK-----GSLAVLAEQGHWQGEVASNRKSGEAFYQRVTINAV
ASQDHNNKHFVYVVADLSQLKNSEAKLLFMQQHDPLTELPNRLLFKSLLEYEIKQSARN-QLVAILMLDLNRFKHVNESLGHRAGDKLLKLVARRLNKTL
DNQYTIARIGGDEFAILLANMPDNSVKLIAEQIIRAMELPFVLADYDFYTTGTIGISLYPEHGSDSETLIKNADSAVHQGKDSHRNGYVFYHYKQSQTVE
SWVRMEPALRQALKNNQFKVFFQPQINTASGAVSGVETLIRWQHPEQGLLPPDQFLPILEAIGLMPEVGRWVIEQACYYLSKWRKNFAVEFKVAVNASSQ
ELLQGDMAAHISSLLDKYNIPANKLEIEILETVIMEHAGQAVPLLTKLRDMGIGLALDDFGTGNSSLSYLKQLPVQKLKIDRAMVQDIESDYKKNAIVGA
IIALGHRLGMSICAEGVESQLQLNFLRREQCEQIQGYMFAKPMSAADFEIWYKN------
>tr|Q2BPN3|Q2BPN3_NEPCE Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) withPAS/PAC sensor OS=Neptuniibacter caesariensis GN=MED92_14593 PE
-----------------------------------------------------------------------SQENLQHKERLLENITQAMPGVVYQYHLD
QSFTYIGPGIETISGIAEAAIE--DFSEFWEQVHPDDRSGLWASIVHTGKHGLAWSHEFRVFHKNGQMHWVRGSALP-SKGSQEGLLWNGIILDITPEKA
SIEQLRLAGIAFSSTNEGIMITDKRNRIIDINRAYMNISGYGRDELIGKNPSILRSEHHSNEFYQSIWKSLEEERHWQGEIWNRLKNGEVVPHWVNINAV
HDPNDALTHFVSVIADISNIKASEEKLSHLAHHDALTNLPNRLLFSARLDHALTHREAS-EKIVMFHLDLDRFKHINDSLGHKYGDQLLLQVTERLKGVL
SDKDTLARVGGDEFAILVEELEHSDAESIADRLVEAMEQPFTLDGKDYFTTASIGLALAPDHGDDIDTLTKHADIALNQAKDSGRNNFAFFQPELSETVQ
EWIKLEPELRKALAENQFQLHYQPQVDSTGTAIVGAEALIRWHHPEMGIIPPNQFLPIAEEIGLMNKIGEWVMNTALEQLSFWRSRGLIGFRLAINLAGD
QITKQNLPMVVMQALEHFQIPAEMLELEILETFLMEHEEEATSTFKQLRELGVHLSLDDFGTGYSALSYLKKLPITKVKIDQSLVRDIPEDPNDEAIAKA
VILLAHTLDLTVCAEGVETRAQREFLESENCDQLQGYLFSKPIEANAFTNLLKK------
>tr|G2FF90|G2FF90_9GAMM Putative signaling protein OS=endosymbiont of Tevnia jerichonana (vent Tica) GN=TevJSym_al00020 PE=4 SV=1
-------------------------------------------------------------------------------SQRFAAILDATTVGLFGLDRD
GRVTFVNGAACRLLGHSEEGLLGGT---HHDRVHYADGSTSECPIHQSLQTGKIVHGEELFFHRDGRGIAVEFTCSPLVD-GGEVEGVVVTFQDISERKA
VKRRLRLATTVFDNTHDGILVTDEKGTILTVNPAFSEITGYSEAEVRGQNPRLLRSGKQRADFYEAMWSTIRQRGRWQGEIRNRNRDGDIFPAWLTISSV
KDDQGEVTNYVGIFSDISPLKHSLEQIEHLANHDPLTGLPNRLLFLDRLKVAVRQARRGGHALAVLFLDIDRFKDINDSLGHAMGDQLLLEMAARVRGQV
REEDTVARLGGDEFVILIGDVESSEAELVARKVMQGLEVPIRLETSEIILRVSMGISLYPNDGESADELIRHADIAMYHAKERGLSEYHFYNDEMSAGTR
ARLAMESALRRAIEGQEFELHYQPQVNLADGGLCGAEALLRWHHPQEGLVTPDRFIPLAEETGLIEPIGAWVLESACRQAVEWQVQGISFGRIAINVSGV
QIRRGTLVERVTTALELSGLDPTRLELEITESVIMEQTGQTLTMLQELKSLGVQLSVDDFGTGYSSLSYLQHLPVDKLKIDRAFVCNLPNAGKDKAIARA
VIALGQGLGLQTIAEGVETEAQRDFLRQHGCQEGQGWLFGRPMTSKLFTQ----------
>tr|N6WUM3|N6WUM3_9ALTE Response regulator receiver OS=Marinobacter nanhaiticus D15-8W GN=J057_07746 PE=4 SV=1
--------------------------------------------------------------------------------RRLTTVLEALPLAVVIADAD
GRISQVNAAAEA--------------LWGDALVSPGYEMGLA---RAIVRGESVLGEEMGIEHPDGSRRTVLNYALPLRDRREDIAGGVSVSVDISDRKR
SRSLLA---AIVEASPDAIVSTDMEGKITSWNTGAERMYGYREDEIIGKSIVIMPPECQDEL---SMVLTAIAKG--QGSVRIN-KAGERVDVSVAVTPI
TDADGRVRGAAKIDRNISERKRMEEQLQHDAFHDRLTGVANRSLFMDRLEHVVARAARFGEPFAIFVMDMDNFKLINDSFGHQVGDQLLCAFVERIQSLL
RPVDTLARFGGDEFTLLLEETEGAAVEQIADRILSALDQPFQLGPHEINVSSSIGIVLDETACQSADQAVRNADVALYEAKRQGKNQYVVFDARMRGEEV
SRMYLESELRLALQQDQLTVQFQPIVDLDVGEPVGCEALARWKHDVMGRVDTARFITVAEDTGLITPLGRFVLEKACATLGEWLKRPEQDFYVSVNVSPK
EFYSGDLVPFVGAMLDKYRLRGANLRLEITENVIIQHDREAAAILGQIQALGVRTCLDDFGTGYSSLSYLQQLPFDVIKVDRSFIQGLSDKQQSREILRA
VLGLATALGMDVVAEGAESPEQLAEIRALGFRWGQGYGLFHPMDRSKLASLLTHPS----
>tr|W0TLG3|W0TLG3_9GAMM Thiolapillus brandeum DNA, complete genome OS=Thiolapillus brandeum GN=TBH_C0050 PE=4 SV=1
--------------------------------------------------------------------------------------------LLERQLKK
LMLARDKAPQDK--------------AWRDFLQKVDDRYT--------------------------------------LERSLT-----ISSDEMLYQQL
KEARLS---AIATAFPDMLFFQDEEGRFLDVLTAHPEALYVPREEIIGSRMDVFEENLSR------CFHKLLSDTLGSGDYREQ-GRRSQASLWLSADRV
QPEINASLYYVILLSDISELHASRMELERLATHDPLTGLPNRILFQDRLEQALTRVQRSGLSGALFFMDLDRFKIINDSLGHQVGDRLLQAVADRLARHL
RQGDTLARMGGDEFTLIVENLKREDVVQLLEKLQEEFRRPFTVDGHELRTTASIGVSVFPRDGSTVEEVVKHADTAMYSAKDGGRDQYRFFTEKLNLSAY
SCFDTEQGLHKALANSEFYLVYQPQYELATGELVGVEALLRWNRSGQGLIRPAKFIPMAEMTGLIIPLGTWVRETVCKQIVAWREEGTVPPRVAINLSSR
ELVRPGLNASVASQMATYRIPAECLEFEITESVIIERGDVAYQNLFSLTEMGIELAIDDFGTGHSSLVNLKRFPLAGLKIDRSFVRDLLVDANDEAIVRA
TIALARSFGMKTVAEGVENHQQLEFLRKAGCDVVQGHVCGKPMSPKGISRLLAASA----
>tr|G2DAF8|G2DAF8_9GAMM Diguanylate cyclase with PAS/PAC sensor OS=endosymbiont of Riftia pachyptila (vent Ph05) GN=Rifp1Sym_aj00080 PE=4 SV=1
--------------------------------------------------------------------------------------------LLTRQLRK
LSLSPDQPPEPA--------------SWQELLSRIDDRYT--------------------------------------LERSLT-----LSSEEMLYQRQ
KETRLH---AIVGALHDLLFLNDEDGLYLEVLTARNDLLYRPAEEIKGKTIDIFPPEMAE------QFLSTIHKALPSGELMVN-GK-------------
-------QTVICLVRDISELRRSREALKHMATHDPLTGQANRKLFEERLDQALSRATRTGHAGTVMFLDLDRFKIINDSLGHAVGDELLKQVTGRLKEVC
RTEDTIARLGGDEFALLIEDIDSADAEHIADKILQRFSAPFFVQGHDLDITASIGITLFPLHGNDGSELIRQADATMYSAKNAGRNCYRLFNHAISQRDQ
AAFGLERQLRRAIVNEELFLEYQPQFRLSDGQLTGLEALVRWRSPGRGLIPPGEFIPIAETSGLIDEIGLWVFHSACEQAAAWDKEELEYCRLAINISRR
QLMHNHLGHSLAEVLAATGARASRLECEITESAVIEEASVASHNLLAMSQLGLQLAIDDFGTGHASLANLKRFPLNRLKIDRTFVNDVGRDPDDEAIIRA
TVYLAHGLGLEVIAEGVENEIQKGFLRETGCDEIQGYLCGRPMPVEQATALLRKD-----
>tr|A0A0B0HA25|A0A0B0HA25_SOVGS PAS S-box/diguanylate cyclase domain-containing protein OS=Solemya velum gill symbiont GN=JV46_20330 PE=4 SV=1
--------------------------------------------------------------------------------------------LLSRQLRK
LDLTGSSLPDDV--------------RWEALLQSISDRYL--------------------------------------LERSLQ-----TSSDELMFQAQ
KDGRLR---ALINTLPDLVFLLDEDGRYVDIISGDEHELVQPSMELKGKLLDVMSSEQAS------FFMDVIHRALQAGGLKVN-DR-------------
-------KAVLFLARDVTELTKARNKLEHLATHDTLTGLPNRVLLENRLCQAVSRTKRTGKKVAVILMDLDRFKHVNDSLGHTVGDELLKEVSHRLKISC
RAEDTVFRFGGDEFVIILEDLESHHAGQAAKHFLDAFNDPLRLTEMELQISVSIGIAVVPDDGEEADILLRYADSAMYMAKEAGRNQYSFFTPELADNSA
NYLALEASLRKAISEHELVLRYQPQYSLEDDALIGLEALVRWPTAAPEFRNPNSFIPMAEITGLIEAMGIWVIEEACRQATTWLKRNLHFGRIAINLSSR
QLNNASLVNEVKDILARYELPGSLLEFEITESMVLHEGGAIYSNLDTFSSMGIDLSIDDFGTGHSSLVNLKRLPLNRLKIDRSFVDGLGEDPNDEAITGA
SIALAKQLGYKVVAEGVETEKQAEFLRQHKCDFVQGYLYAKPMLSDEVEELLIQNH----
>tr|A0A0A0C0P0|A0A0A0C0P0_9CELL Uncharacterized protein OS=Cellulomonas bogoriensis 69B4 = DSM 16987 GN=N869_13315 PE=4 SV=1
--------------------------------------------------------------------------------HRLASVLDLEALVADADRAE
LVLVDDPDPGRP--------------GWETACGGAPGSAVLA---APVVRDGSCMAVLYAYR-RDG-----RTFSKDALESATVVATSVAAAMSNLYRA-
LEASLR---LITDSISDMVAVVDGRGLFAYASPSHERALGHTVPDLLGRAVDLVHPDDQP------LLRTAIAQPMRP---------------------L
RPAPGSDTRLVLSSRVVDERRRLEEELRHRAMHDPLTGLANRTLTADWLEAALAREAD--SCVGVLFCDLDKFKEVNDRLGHEAGDELLVQVADRLRGCV
RGGDLLARFGGDEFVIALDGVCDAEVEQAGQRVVSALSGSFLLRGEPVEVTASIGGVLGSRRSAEPGALLRDADAAMYAAKGAGRGGVQVFDEAASRRAL
DRLELRSDLAHAVARDELVVHYQPLVDLLDGAVLGFEALVRWLHPVRGLVPPDQFIPVAEETGLIADIGTWVLDEACRQLAEWQAEHPRALRMSVNVSAA
QLHDPTAAARYLQGITAAGVQPRDVWLEVTEHSSVRSEVSV--FAHEMHRSGVRFALDDFGTAYSNLGDLTRLPVEALKIDRLFVSRLTADRAERGLVQA
VLAVARSLDLQVVAEGVETQEQREELLALGCRQAQGYLFSRPVPAEAAAELLRTGT----
>tr|Q2BR68|Q2BR68_NEPCE Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) withPAS/PAC sensor OS=Neptuniibacter caesariensis GN=MED92_07561 PE
---------------------------------------------------------------------------LNERETLLRTVIDEMPDVLVLKDHK
GNFLLGNNTVARLYNTTPEEMVGKN---DADFGVPQEMA---DFFREAMEKGPEVVMEDSTDTASGEVRHFKSIKKPFKDADGN-NQILVIAQDITEIVE
AQRQLEISEKKFRTILDYIYLKDKAGHYLFANRKVRELWGAAMEDIVGFGDDKFKIAGEAAYDLIYEWDVETDSLHWFGDIDDQHKKGHYLYLSDHALPL
LDENRRPYRWIGVCTDITTQKEQQLLLEFNAYHDKLTNLPNRVLLADRLSQAMHQQKRRGQTLAVVYIDLDGFKQINDQYGHDVGDVLLVEIGQRFQTLL
REGDTIARLGGDEFVAVMLDINSMDSIPLLRRILHAISVPVLVDDVVLQVSASLGVTFYPQADVDGDQLLRQADQAMYQAKLEGKNRYYFFDMEHDRSLR
GQRETVERIELGLRQREFELYYQPKVNMHSGDVIGLEALIRWNHPEDGLLMPGQFLPVIEDKPVAIEIGEWVIEDALRQMDAWSFQGHD-LSVSVNIGGL
QLQQDNFVERLEALLKKFRVASECLELEVLESSALQDIQLVSKVMQRCNELGVSFSLDDFGTGYSSLTYLKSLPAANLKIDRTFVRDMLDDPDDLAILEG
VVGMSTAFRRGVIAEGVEEIAHGEMLIKLGCNLAQGFAIAKPMKAALIPDWISSWNPPK-
>tr|A0A0A0BHE0|A0A0A0BHE0_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Methylophaga thiooxydans GN=LP43_0371 PE=
--------------------------------------------------------------------------------QKFRHLIESSPIPYLLLNAN
REVSFINQAFSDNYGYQLEHVQEGE---SQITAHPQRFK---AYLS-HGDKTPPSSMELEINTLHGQTKVALLSTSFLQDTFD--SELLLVVYDITVRKE
AEEQLRFSSRVFNQAQEGIIITDTSGTITDVNPAFCEITGFSREEVLGKGPDILNSGKHSPEFFSKMWQSIIDHGYWQGEVWNRRKNGELYAELLTISAI
TDDDGQSRHFVGLFSDITQTKQQQETLEMMAHYDVLTKLPNRVLFADRFSQAMAHSNRTETMLAICFLDLDNFKPVNDTHGHEVGDQLLIEVAVRLRKNV
RDEDTISRFGGDEFAILFRDIESSECEFMLRRIHESLAQPYNVNDTRIEISASSGVTFYPQENADLDTLLRHADQTMYQAKLAGRNTYKLFNPAQNRQNI
EKQQWLQQIRLGLEQDQFRLFYQPKVNMRTGEVFGMEALIRWLHPNKGLLSPIQFLPLIEGTEIEIDVGNWVMRSAMQQLQVWHGEGKE-IEVSVNVASL
HLQSAHFIDDVEAALATHDIESRYLQLEIVETSALGDIGAISKVIKLCRLLGVSIALDDFGTGYSSLTHLRHLTASTIKIDQSFVRDMLDDPQDYTIVDG
VSGLAEAFNRQVIAEGVETTESGLMLLMSGCERAQGYGIAKPMPAEEVLVWLNDYKPNI-
>tr|F5SZL0|F5SZL0_9GAMM Putative signal transduction protein containing a membrane domain, an EAL and a GGDEF domain containing protein OS=Methylophaga
--------------------------------------------------------------------------------YKYRNLIQSSPVPYVLMDKQ
QRVTFINQAFKETFGYSLEDIESLP---NQLIAQVQQLK---QDFVTT--ISMSNAFEIEIQTKSGKSRVVLVSSSVVENTFG--DETLLVIYDITVRKE
AEEQLRFSSRVFNQAHEAIMITDTRGVITDVNPAFCNITGYSREEAIGHTPHLLSSGKHPPEFFQNMWKSITEHGYWQGEVWNCRKNGELYAELLTVSSL
MDDDGTTRHFVGLFSDITQAKEQQDILELMAHYDVLTKLPNRVLFADRFSQAVAHCKRSGSMLAICFVDLDDFKPVNDTYGHDVGDQLLVEVANRLKSNV
REEDTISRFGGDEFAIIFRDVESEECEEMLKRIHQSIAQPYHVDDLRLNISASSGVSFYTQENDDLDTLLRHADQSMYQAKLSGRNHYQLFNPADNQLNI
EKQQLLHDIRQGLQSNEFRLFYQPKVNMTTGEVFGMEALIRWQHPTRGLLTPLKFLPLIADSELEIEMGQWVLQQALQQLQLLHHAGYR-ISISVNIASY
HLQSAYFVETVEAMLNQYDISTDYLQLEIVETSALGDIGAITKIIRKCRSLGVSVALDDFGTGYSSLTHLRHLNADTIKIDQSFIRDMLDDPQDYTIVDG
VTGLAEAFNRQVIAEGVESVEHGLMLLLIGCENAQGYGIAKPMPSDEVLPWLAHYHADP-
>tr|M7PPA7|M7PPA7_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Methylophaga lonarensis MPL GN=MPL1_11148
--------------------------------------------------------------------------------LKFRKLIENSPVPYLMIDRQ
GHINFANQAFTDSYGYSAEQLVDLN---QQKTTVSDVIA---DWIRST--NSGTIDNELTITCSNGQTRHALLSTSILKDTHS--DELLLVIYDITLRKL
AEEQQRFSARVFAQAHEGIMITDVHGVILDVNPAFCEITGYPREEVLGQTPALLKSGKHPPTFYALMWKDIQDQGYWQGEVWNRKKNGELYAELLTISAL
SDDHDEARHYVGLFSDITQSKQQQETLELMAHYDVLTKLPNRVLFADRFSQALAHSKRTDTWLGVCFLDLDNFKPVNDNYGHEVGDQLLVQVARRLDEIV
RDEDTISRFGGDEFAILFRDLESSQCELMLQRIHHALAKPYFINGQQIEISASSGVALYPQDDSDLDTLLRHADQTMYQAKLTGRNTYRLFNPEQNQQAI
ERHNLLVRLREALDAGEFELFYQPEVNMKTGAVVGVEALIRWRHPEKGLQAPITFLPALAGSTLENELGDWVIREALQQLQQWQDQGHK-LLLSINIAAQ
HMQSKDFVSNLANRLSQYKLKAGNVQLEILESSALGDVRAIGQVIKQCEALGVVIALDDFGTGYSSLTHLRHLAAQTIKIDQSFVRDMLDDPHDYTIVDG
VIGLAKAFNRQLVAEGVETESHGMMLLMMGCELAQGYGIARPMPAQEVAGWLQNYQPNQ-
>tr|I1YJV0|I1YJV0_METFJ Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Methylophaga frappieri (strain ATCC BAA-2
--------------------------------------------------------------------------------LKFRHLIENSPIPYLLVSSK
KQVSFINPAFTESYGYRLDNFPQLM---AQQTSLDPGLN---LWLEGA--SESKTTTEVTITCPDGSERVALLSFSALQDAFE--NELLLVFYDITVRKT
AEQQLRFAAQMFTQAHEGIVITETDGTIIDVNPAFTSITGYPREEVIGQNPSLLKSGRHDDGFYAAMWQALDKDGYWRGEVWNKRRDGELYAQLMTISAL
AGKDAQERHYVGLFSDITQTKQQQETLELMAHYDVLTKLPNRVLFAERFQQATEHSRKTQTWLGVCFLDLDNFKPVNDTYGHSVGDKLLVEVAKRLTDCV
REGDTLSRFGGDEFAILFQDVESEQCELFLQRIHETLAQPFKIGDLELSLSASSGIAMYPQDDDNLDTLLRYSDQAMYQAKLTGRNTYQLFNPHENQQTI
EKHALLQALRVALQEDQLCLYFQPEINMRNGKVMGVEALIRWQHPEQGLLLPGQFLPVLADTELEIQVGNWVIQQAIRQIDAFQNVKQP-LFISVNIAAS
HLQSRDFVSNLQAALAAYQVLSPSLQLEILETGALGDVRTISRVIRDCRQLGVQVALDDFGTGYSSLTHLRHLSANTIKIDQSFVRDLLDDPNDFNIVEG
VIGLARAFDRQVVAEGVESEAIGQMLLLLNCDLAQGYAIAKPMPAADFIDWIAHYQPLP-
>tr|I1XFV4|I1XFV4_METNJ Methylophaga nitratireducenticrescens strain JAM1, complete genome OS=Methylophaga nitratireducenticrescens (strain ATCC BAA-24
--------------------------------------------------------------------------------LKFRQVIESSPIPYILVGKD
RKISFINPAFAEHYGYSLTDLPSLA---LNKTDINQEIN---TWCDSD--EQPDHAVEISVQCKDGVQREVLLSVSPLDDTVN--KELLLVVYDLTSRKL
AEQKIHFSEQIFSQAHEGIVVTDTQGRILEVNPAFTEITGFTAQDALQNTPAIMKSGKHDDVFFEEMWRKLENHGHWQGEIWNRHKDGHLYALQLTITVM
TNPQGLKQYYAGLFSDITQSKTQQEKLELMAHYDVLTHLPNRVLFADRFSQAVAHSQRLGTWLGICFLDLDDFKPVNDTYGHNVGDLLLIEVADRLRASV
RDEDTISRFGGDEFAILFRDINSEQCEQLLIRLHQTLAEPYWIDNRSITISASSGIALYPMDNVDLDTLLRHADQAMYQAKITGRNTSRMFNPELNQQVI
HKHHVVQRLREALLNDEFVLHYQPEINMRTGEIIAVEALIRWHHPERGLLFPGDFLSDVEGSELEFELGLWVIDSALQQLQYWQQAGLE-IVVSVNIAAN
HLQAKNFIQSLQQILNRYDIRPASLQLEILESSALGDVPTLSRIIDDCRRVGVLIALDDFGTGYSSLTHLRHLASNSVKIDQSFVRDMLEDDSDYNIVDG
VISLAKAFNRQVIAEGVETVEHGLMLLSMGCDLAQGYQIARPMPAENVLNWCHEYQLQH-
>tr|G7ETV0|G7ETV0_9GAMM Sensory box protein OS=Pseudoalteromonas sp. BSi20311 GN=P20311_2118 PE=4 SV=1
---------------------------------------------------------------------------LTDTERLLSQKVGGIAWEWIIRFSE
HGIRLINGNVKQLE-------MTKN---EAI-IYPDDRA---DIIKNC--DDKEYNVDHRIVNKRGKIRWFNTKGTLVRDNQGSAVTMLGVSIDITERKL
IEEKLHLSSRVFRDTHEGIIITDVNRHIVDVNPAFCRITGYSHEEVIGRTPAFLNSGKQSDSFYKDMWLQLNKFGHWQGEIWNCKKNGELYAELLTISVL
TDDNDV-TFYLGIFTDITQAKRQQEQLSRIAHYDLLTNLPNRVLLADRLSQTMLQCRRHNNSLAVVFLDLDGFKQVNDSHGHDIGDKLLVAISIRLKDAL
REGDSLARIGGDEFVGVLTNLESADCVPVLERLLAAAAKPVTVNDIVLNVSASIGVTVYPEDNFDADQLMRHADQAMYIAKQMGKNRYHLFDTSQGDTVK
TQQKGITLIREALANNWFVLYYQPKVDMRTGDMIGVEALIRLQHPERGLLSPIEFLPAIENNQLMIDVGEWVIDTALTQINQWQSLSLT-IKVSVNVAAV
QLQQPEFTSKLTELLLAHQVNATNLELEVLETSALSDVTHVSKTMQDCKALGVDFSLDDFGTGYSSLTYLRRLPASLIKIDQSFIRDMLEDSDDLAIVKG
VIALAKSFKRKVIAEGVETPEHAATLMLLGCHLAQGYGIAKPMKAEDIPIWLNEWTADE-
>tr|E6RRK5|E6RRK5_PSEU9 Sensory box protein OS=Pseudoalteromonas sp. (strain SM9913) GN=PSM_B0522 PE=4 SV=1
---------------------------------------------------------------------------LTDTERLLSQKVGGIAWEWIIRFSE
HGIRLITGNVKQLE-------MTKN---EAS-IHPNDRA---NIVSDC--DAKEYNVDHRIITKRGNVRWFNTKGTLVRDNSGSAITMLGVSVDITERKL
FEEKLHLSSRVFRDTHEGIIITNADKVIVDVNPAFCHITGYSHDEVIGRNPSFLNSGKQTESFYKNIWKQLSLYGHWQGEVWNCKKDGELYAELLNISVL
KDDNNV-TFYLGIFTDITQAKRQQEQLSRIAHYDLLTNLPNRVLLADRLSQTMLQCRRHNNSLAVVFLDLDGFKHVNDSHGHDIGDKLLIALSIRLKDAL
REGDSLARIGGDEFVAVLTNLGSADCVPVLERLLAAAAKPVTVNDIVLNVSASIGVTIYPEDNLDAKQLMRHADQAMYIAKQMGKNRYHLFDTSQGDTVK
LQQTGISLIREALANNWFVLYYQPKVDMRTGSMIGVEALIRVQHPERGLLSPIEFLPVIENNALMIDVGEWVINAALSQINHWQILSLN-IKVSVNVAAV
QLQQPEFTARLTELLLAHQVDARNLELEVLETSALNDVAHVSKTMQDCKALGVEFSLDDFGTGYSSLTYLRRLPASLIKIDQSFVRDMLEDSNDLAIVKG
VIALANSFKRSVIAEGVETPEHAATLMLLGCYLAQGYGIAKPMKAEDIPIWLDEWTADE-
>tr|I3Y9R3|I3Y9R3_THIV6 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiocystis violascens (strain ATCC 17096 / DSM 198 / 
------------------------------------------------------------------------------LLARSADIVSTSPDRIALVDRG
RRIKAVNDAFLRTVDRARDELIDQD---VKNLGGDDQLTALDRNLGPCLDSGRILIEDIRETRGDGAPRDAEVRLFPHHDAEGTITGVIVDIRDVTASRD
AERRLLQSAAVYAATSEGVLITDAAGLIVAVNPAFTRITGYTESEVLGQKPNLLNSHWHPRSYFVGMWRLLSRQGSWQGDIWNRRKDGEIYLQKLTIRRV
LDAHGKVVNFVGVFAARN--HAPPRRTGHLIHYDALTKLPNRLLFESRLEHAIELGRRKASPLALVLFDLDHFAHINSSLGHQLGDQLLRAVALRLRGVI
RPSDTLARLRADQFGLLFEEIERTEVEDIARRLQAVLCADLQVSNHQVFLTASIGAAIDVDMKSDRNALFAHAESSLRSAKRQGRNGLLISRIEPGKAGH
EHQRLIDLLRTGLVKGEYRLMYRPRADLETGVHTSAEVLIRWDQEEIGTVPPERFLTLANESGFMAELGEWELAMACRQLQHWLGKGFAIGGLSIHVSEA
QLTRGNLIQILERLLVENPLTANRLDLEFNESLLQKHPEQIAGVFDGLRRLGVSITLNDVGAGWTSPAALRRLPIKTLRIHPNFIESLPESHDDLAVVQA
LVAMAQALDLEILADGVRTDEQRQLLLTIGCQQAQGALFGEAVFAPHFEHRLDPK-----
>tr|D3RPP3|D3RPP3_ALLVD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 1038
------------------------------------------------------------------------------GQTLYAAIFAALSGRIALIDRG
CRLLAANPAFLAAIGREQDESIGQS---FMTLCGASTLTTVYRHLGTCLDQGRSIVTDWLETTDSGVRHEHEVRLLPCRDLQGEITGIVIEMCDVTAMRE
AERRMLQSAAVYAATSEGVLITDSEGIVVAVNAAFTQITGYAESEILGQKPTLLNAQWHSRVFFINLWRRLLRQGSWQGEIWNRRKNGEIYRQRLTIRRV
LDPRGRLINFVGLFAERTASPGTPRLAEHLIHYDALTKLPNRLLLESRLDHAIELGRRKESPLALFIADLDHFSHINASLGYQIGDDLLRAIGLKLREAI
RPSDTLARLHADQFALLFEEVDDDEIVFIANRLKTLMSAPIWIRGHQLHVSLSIGIAVSTELREDRRALMANAESALRQVKRQGRNGFQILSSAPDQVAR
EHRRLLDRLRAALGTSEFQLHYRPGMDMATETLDSVAVSIHWEPPELGMISQERLLPLAEESGLILELGDWILTGACRQLQDWIDRGLSIKRLVVEISEA
QLTRGDLARTVAQRLEDYPAAATRLDLEFSERLLVKHREQIAEVFQGLNELGVGICLGEVGIGWTAPALLQRLPIRALKIHSNFIEALPDAHHELAVVEA
LIAMAQALGLEIRADGVRTKEQQYQLLSIGCLKAQGDLFGEPLRAAQFESRMTPQ-----
>tr|W9VZU2|W9VZU2_9GAMM Uncharacterized protein OS=Thiorhodococcus sp. AK35 GN=D779_0957 PE=4 SV=1
------------------------------------------------------------------------------ALARYADIVSSSPDRIAYVDRG
CHLLAANTPFLRAAGHAGEIVAGRP---FKDACGKGPLTALYSSLGRCLDQGDIIVEDIQELGRDARPRDAEVRLFPHRDDQGVVNGIVINIRDVTKVRE
TERRLLQSAAVYASTSEGVVITDAGGTIVAVNSAFSQITGYTEADVIGNKPNLLNSQWHPKSFFISMWRRLLRHGFWQGEIWNRRKDGEIYRQKLTIRRV
VDPRGRVLNFVGVFADRSAASTPPQRAEHLIHYDALTKLPNLLLFESRLEHALELGRHKETKIAALLLDLDRFSNINDSLEHHIGDELLRAVAMRLREVI
RPADTLARLRADQFGLIIEEIYEDEIAEIARRLQSSLRAAFWVEGHEVFVTVSIGIAFNDDANIDRGTLIARTESALRMVKRRGRNGFRIATSEPSEPRS
DQQHMAAQMRAGLRNHEFQVLYRRGFDLLDKRCILVQARLHWAQQELGLVTPERFLTLANDMGLALELSQLTLRTACRQLQTWVAQGLPVTCLSVAISET
QLIRGDLVPTVAQLIEEHPLTAHRLELEFSEALLFKHREQIAEIFVGLNRLGVMTTLSEVGGGWTAPAVLQRLPIKTLSIHADFIECLTDSVHDQAVVQA
IINMAQALNLTTRADGVRSDKQFNLLSTLGCNEAVGDLWGEPRSAEDIQILIDPN-----
>tr|W0E0Q5|W0E0Q5_MARPU Diguanylate cyclase OS=Marichromatium purpuratum 984 GN=MARPU_02170 PE=4 SV=1
------------------------------------------------------------------------------ALSHYSEILAASSERLAFVDPE
HHIRAVNRAFLNALDRDYDAVIDQP---LGRVISDQTLGALQQALEHCLAHAKEHAEDLRRPGPDGEPRDLEIRVSPHHGDDDQLAGAVINVRDVTLVRE
AERRLLQSAAVYAATSEGVLITDPEGGIIAVNAAFSRITGYTEAEVLGRNPSLLNSHWHPRSFFVGMWRHLLKHGSWIGEVWNRRKDGEIYLQRLAIHRI
VDARGNLLNYVGVFAEHSATLNTPRRAEYLAHYDQLTKLPNRLLFNSRLEHAIELRQRKQIPLALFLIDLDRFANINTHLGPQIGDELLRSVALRLRSEI
RPADTLARLSANQFGLIFEEIPGGEAESIAQRLQNCLAAPFHIREHEVFVTASIGIAFDPSTGRDRDLLLAKAESALRAVKQGGRNAYRCLAIHTDAAAE
ERQRLIGQLREGLERGDFQLHYQPRVDVESGRWCGIEAMARWNQPQLGLVAPERFLPLTDDGGFLVELGHWTLNRACEQFQRWRSRGLPVGRLALNVSEP
LLLRLDLASTIARALDTHGLAGDQLELEFTEGLLLKHSDQIVELFAALHQLGVHLTLRDVGAGWLAPSLLRRLSVGTLSIHRGFIENLPEAQEDLDVVHA
IVALAQSFEIGLLADGVRTEGQRELLLTIGCPHAQGELYAPPLPPEQLEHRISQK-----
>tr|A1K469|A1K469_AZOSB Uncharacterized protein OS=Azoarcus sp. (strain BH72) GN=azo1007 PE=4 SV=1
------------------------------------------------------------------------------ADTVWPRLAAALSQGVLVLDDG
DRITAANAAALHLLGRTRDDVLSRP---LADHLDVS----------------------WPAPGQPALALPHASAPLPARVLAGPRAGWRLLVLPPRTEDT
ATEGLHLPVDVFDAASQAILVTDDQNRIVAVNRAFTEITGYSRDEVLGQNPRLLSSGRQEPAFYAEMWQTLEASGQWQGEIWNRRQNGEIFPEWLTITAV
RDAQGAARHYLAMFTDLTARRQAEARAEYIAHHDILTGLPNRRLFEARFKEAAEQARRRRCSVGVLRIDIDQFKAVNREHGDNTGDAFLQQIARRLQASL
PRGAVAARERSDTFLALLPELDLSAASRAADDILAALGPAFRTESCEVAISASIGIALFPGDGADLDTLLRHAGIALRQARQLGGNSHQRYQAGQG-GGI
EQAEFGAELHGALTRRQLEVYFQPLVDARSGRVRAGEALLRWRHPELGLIPYRHFVATARHNGLVAAFGDWALVTACNAAARWPQGAQGVPAVTVNVALE
QVLRGDFATTVDKALAASGLAATRLELDLDEAILASDDEVTLATLRTLAKRGIRFAIDDFGRGLSSIPRLRRFPVQALKLDPALVGGVGKDEDAEAVVEA
IARLAASLGIEVLARGVADPAQQAFLSALDCHFQQGPLFGAPLPAPAFAALLETA-----
>tr|U6BF07|U6BF07_9BACL Uncharacterized protein OS=Exiguobacterium sp. MH3 GN=U719_14575 PE=4 SV=1
----------------------------------HVIIGLYG-IARD---------------VSQ---QKELRTAYNRLLAKEQLTTTLEGVTFLEYIPS
TKQLTADAALSQLLEWSQRHVAQMDAYELLDEIHPEDRDLFLQQSTALCDEIAEFSMSLRMSKRRHYTKVVRCDALLQQNS--SPRCVNFILHDATELTS
LERERDHAIDVFGSLDTSIYEHIYPQTVTFQSAGFLAPYQHILNRIEKE-PQLWRTLIEDLPHLELSYPEIRNGKVIRHVYRLQLLD-NVFWIEETCIPI
LDNKGDVSGHYGVSSDITILKEQQHTIWHLSMHDSLTQLPNRAFLLEEITSLLKT----RTSFTLLAITFKQYNVIHERFGHDVGDEWIRQTSTEVRRFA
DQDHFVGHLFGDKYLFIIKKPIDTAIVKLSHQLLKLSEKRFDVLSYELFTNVYIGITYVVNDKLSADELLKQTYTALRRAKSRTKSNYQFYSTTLDIDMY
RRYELERDLRYAIQNEQLVLEYQPKVDGWNGNIQGAEALIRWNHPEWGRLTPKDFLSLSEESEMYLHIGDWVLDQTCRFLSKLRERHSNIVPISINVSPK
RLFYGDFGQVIEQYLKRYRVPGHLLEIELLESDILLESDKIHEILERISALGVHISLDDFGTAYSSISHVQRYPINCLKIDRSLAQLIEHDPKSRSIVKS
ILFMAKEFQLTVVAEGIETIPQLDFYRELQCDLIQGYLFSKPVSESTFEKLLTKG-----
>tr|B1YMQ7|B1YMQ7_EXIS2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-1
----------------------------------HVIIGVYG-IARD---------------ITQ---HIQLRLQHTRLSAKEQLTASLPGLAFFEYETT
RDRLTLSAHFASLLDISQHRLASLEYDEFLLEIHPDDRSRFKQQLTLLQ-PEPTASCTLRMNQTRDYTQEVICQGLRSEDG--SEELFSFLFQAVTKA--
------TD--------------------------------------------------------------------------------------------
------ETDT-KRVSD-RTILDQEEDIRKLSLYDQVTGLPNRTLFLEEVEHLIRT----DHPFTILSLDFNQLHRINEQIGYDIGDQWLRQTSRYLTE-T
LPDLYCARLTGDHYAVLSTQPFDVALKAMCLDLLALNTTRIQIEGYELVAELAIGLSPFQHDEMAATELLHTASRALSRAKLKAQPAYEFYTSQLDLEIY
RRHQLEQSLRNAIQQDELFLEYQPKVDIWSGQILACEALIRWDHPEWGRIPPQDFIPLSEEGHCYLPIGEWVLETVCRTIQSLLQQQSPVVPISINLSSK
QLLHRDFVDTVRTCLHRHQVPARYLQLELQESVLLHESEFVKETLQQLHQLGIQLILDGYGSGVSSLSSLQTYPISSLKLDRSFVARLEEDEQPVPLIKS
IVYLAKEFQLSVVAEGIETLHQLDQFRDFECHAVQGYLFSRPVGIDTLRLLLKQG-----
>tr|K0AGF5|K0AGF5_EXIAB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Exiguobacterium antarcticum (strain B7) GN=Eab7_2475 PE=4 SV=1
----------------------------------HVIIGIYG-IARD---------------ISQ---HLQLRLHHTRLSAKEQLTASLPGLAFFEYETT
ADRLSLSTHFATLLDVSHHRLASLDYDEFLLEIHPDDRSVFEEQLTLLQKESSTVSCHLRMNQKQHYTRQIQCQGVRVEDE--RQELFSFLFRETARHTP
LGGTKKTD--------------------------------------------------------------------------------------------
------RSQQ-DDVPD-STLMQQQEDIRKLSLYDHVTGLPNRMLFLEEIEHLTRK----KHPFTILSLDFNQLHQINEQIGFDIGDQWLRQTSQFLTE-Q
LPDMYCSRLAGDHYAALWTEPFDLQLKKTCLDLLSVNTTRFQIEGYELAAELAIGISPFQTEETTATELLHTANRALSRAKLKPQPAYEFYTSQLDLEIY
RRHQLEQSLRNAIEQKELFLEYQPKVDIWSGQILTCEALIRWDHPEWGRIPPQDFIPLSEEGHCYLPIGEWVLETVCQTLQSLLHNALPVVPISINLSSK
QLLHRDFVQTIRTCLHRYQVPARYLQLELQETALLQESEFIKETLQQLHQLGIELTLDGYGSGVSSLNSLRTYPISSLKLDRSFVAQLEEDNSPAPLIKS
IVYLAKEFQLTVVAEGIETLEQLDQFREFECHAVQGYLFSRPVGIEQLPVVLKQA-----
>tr|B1YEI5|B1YEI5_EXIS2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-1
----------------------------------GLIVGAYG-IARD---------------LTT---NRLMRQQMDSIQFDQQLVETLPGIALAAFNEH
GNLLRSSDSFAELFGVRPEQLKHLSKQEFLQRIHPADQQEFREYLDLLKTNLPSLDIETRVLHPQHGYQDIFCRCAFRQDDRQQQAELACVIYNLSEHKS
LDKQLHDEKTFQQVSTSAIYRYDIQKKIDFHTRGFENIFEGLLHRHQQV-DGLWIDLIEDRSKVEASYHRVLANHESEVSYRIR-HDEMIHWILENRTPI
RGADGVVSAFQSVIQDITQLKQQEEKIFQLAMHDRVTGLPNRTLVLEQMNQWIAT----YPTFSVLTVSYNALQDINHDFGYPIGDKWLSKTATQLLHHL
PTASYFGHLYGDEYIVLFPNVVECSINKICEQLIELSKQKIVIDSYEWYPSIGIGVSRFPEDADSAEDLVKTASIALGRARVNE---YSVYSSTFNIETY
RRHQLQKSIRTAIRRNELFLEYQPKVNAWSGTIVGAEALIRWQHPDWGRIPPNDFIPLSEESEMHILIADWVLEETCRNINQWILADLPIVPVSINVSPK
RLIHGNFAETCQETLQRFGVSPSMLEIEILETDVLFDNSKIQQSLQMLSQMGIKIALDDFGKGYSSISYLQQYPIDTIKIDRQFATTLVQDKKTQSVVRS
VLFMAKEFGMDVVAEGVETMGQLHFLRGLECTTIQGYLFSKPLPKADFEQAMRRR-----
>tr|K0AE36|K0AE36_EXIAB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Exiguobacterium antarcticum (strain B7) GN=Eab7_2300 PE=4 SV=1
----------------------------------GQVVGVYG-IARD---------------ITR---EKQLEDDVVQIRSQLKLREQIPELVVFQYDAL
TRKIESSASLINYLGFSQLELKQLSNKQLHKRIHPRDLDPLRFQMIRLLEGVDSFEQEISLLNANQQYQLLRLK-ASRSNE--DKNQISMVLYDLSEVSE
ARQQLKLEREIYEALEAAISQIDLTGRILFHSKGFFQLFEELPDDL-IL-SEEWLGRLRDISAMKRFIKRLMSGKSGMIQYRLLFPDGRLKWIEDQQIPV
FRLDGSIAYTNSIMHDITLQKEYEERLQQLAMHDSVTGLPNRLALTKTIKDWMQA----NTAFSVLSIAFNRISDINNAFGHASGDQWLQATSALLSTSK
TAEVFLGHLGGDEYTMLIPSSFK-DITSCAETLLQLSTKPILIEQYALFARVSIGISRFPDDSNNSVELIKHSYTALRRSRRENHSTVHHYASNLDIDYY
RRYRLEQDLHYAIERDQLFLEYQPKVDSWTGKIIGLEALIRWQHPEWGRIPPNDFIPLAEESALHIAIGDWVVETACQAMINWSRAGAELVPISVNVSPK
RFLIPGFEHQIEQALTTYKLSADLLELEITEAALIMDDPNISRTLEHLSQLGVRIALDDFGKGYSSMVYLQRYPINVIKIDRQFATHIVEDRKAQAIVKS
ILYMATEFNLAVIAEGIETLQQLEMFRSLNCPNIQGYLFSRPVSAEVMESFLLRE-----
>tr|S3FK21|S3FK21_9BACL Sensory box protein OS=Exiguobacterium sp. S17 GN=L479_01364 PE=4 SV=1
----------------------------------RVITGLYG-VVKD---------------LTT---QTELREQYNRMKVGRTLFERIPGLILIELNLE
SGEFYHSPQTGELLGLSRRQLGGMEREHFRDMIHENERETFAAAVESLINDQHDYETQVKAFNPQQKYLDLIVHVGISK----DRKSVTWAMFDLTNLVD
AESALTKERQLCEIVDSVIFERYFSNQFKFLTPGFSLIFGYTEDQFNTH-PDYWKRIVDDLPKIKQAREMTLSGKPVTFSYRIF-AKGNVKWVEENREPI
FSEDGIVIGFRTLVKDITQLKEQQQEIWRLASLDPITNMPNRESITESVYQLTRK----RDPFTLLSLSFNRIAEINNTFGYELGDEWRVATVNQLIRLL
PKDALLGHLDADNVLIVLPRRMEPEVIALGKKLGTLSKYRFHIDVYDLFARISIGVSRYPEDGAQASELIKHACVAMNRADKKFGTQLELYSSQMDIESL
KRYELLRDMRDALKNNEFYLMYQPKVNAWTGQIVGAEALMRWTHPTWGSISPAEFIPLAEESSLHLDLTNWLIEEVCRYITSLKH----RVPISINVSAK
YLYQERFERVFEDMLDRFHVPASYLEIEISETSLLDDSQQITQAFERLNSLGIPIAFDDFGKGYSSLAYLQAYSAQTIKIDRIFAHNVNQSRKAQGIIRS
LLLIAEEFGMNVVVEGVEMMDDLLRLREFGCHVIQGFIFSRPLRESDFEQALATG-----
>tr|A0A099DJA8|A0A099DJA8_9BACL Uncharacterized protein OS=Exiguobacterium mexicanum GN=JY98_08035 PE=4 SV=1
----------------------------------RVITGLYG-VVKD---------------LTT---QTELRERYNRMKVSRSLFERIPGLILIELDLE
TGTFYHSPQTGNLLGLTKRQLADMKREDFRNLIHEDDRGAFAAAIETLLHDQFEYETQLRAFNPMKQYLELIVKVGVSK----DRKAVTWAMFDVTNLVT
AEEELTKERQLCEIVDSVIFERYFSKQFKFLTPGFSLIFGYTEDQFNAH-PDYWQKVVDDVPKIKQAREVTLSGKPSTFSYRIF-AKGNVKWIEENREPI
FSEGGHVVGFRTLVKDITQLKEQQEEIWRLASLDPITNMPNRESITESVYHLTRK----RNPFTLFSLSFNRIAEINHTFGYELGDEWRVATVNQLIRLL
PKDALLGHLDADNVLIVLPRRLEPEVLTLGKKLGTLSTHRFRVDVYDLFARISIGVSRYPEDGTQASELIKHACIAMNRADKKIGAQLELYSSQMDIESL
KRYELLRDMRGALQNKEFYLMYQPKVNAWTGQIVGAEALMRWTHPTWGSISPAEFIPLAEESSLHLELTNWLIEEVCRYLMTLPK----KVPISINVSAK
YLYQEHFEHVLEDTLARYHIPASYLEVEISETSLLEDAQQITQAFERLNDLGIPIAFDDFGKGYSSLAYLQAYSAQTIKIDRVFAHNVNQSRKAQGIIRS
LLLIAEEFGMNVVVEGVEMMDDLLRLREFGCHVIQGFIFSRPLKESEFEQALEAG-----
>tr|B1YLJ8|B1YLJ8_EXIS2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-1
----------------------------------GHVVGVYG-IARD---------------ITR---EKQLEDDVVHIRSQLELTEQIPELVVFHYDPT
SRTIEYSPSLIKYLGIESNPVQPFTNEQLHQRIHPRDFDPLRFQMIRLLDGIDTFEQEVSVLNADYEYQLLRLK-ALRRDG--PTGLISLILYDLSEVSE
ARRELAREREIYEALEAAISQIDLTGHLLFHSKGFFQIFEELPHDL-IL-SRDWLERLRDVPAMKQFIRRLTSGKPSTIQYRLLFPDGRMKWIEDQQIPV
FQLDGSIAYTNSIMHDITLQKEYEERLQQLAMYDSITGLPNRLSLTDTIRNWMQA----NTPFSILSISFNRISDINNAFGHASGDQWIQATSALLNRSR
PDEVFFGHLGGDEYAMLVPSSLK-DITSYAETLLSLSVEPILIDPYALFTRVSIGISRFPDDSNDPIELMKHSYTALRRSRRENQSAVHHYASNLDIDYY
RRYRLEQDLHYAIERKQLFLEYQPKVDSWTGKIIGLEALIRWQHPEWGRIPPNDFIPLAEESALHIAIGDWVVETACQAMLDWSSAGADLVPVSVNVSPK
RFLIPGFEHQIEQILAAYHLPAELLELEITEAALIMDDPNISRTLEHVSRLGVRIALDDFGKGYSSMVYLQRYPIDVVKIDRQFATHIAEDTKAQAIIKS
ILYMAKEFNLAVIAEGIETIQQLETFRALECPNIQGYLFSRPVSAAVMESFLIRE-----
>tr|K0AEJ9|K0AEJ9_EXIAB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Exiguobacterium antarcticum (strain B7) GN=Eab7_2514 PE=4 SV=1
----------------------------------GLIVGAYG-IARD---------------LTT---SRLMKQQMDSIQFDQQLVETLPGIALAAFSEE
GHLVRSSESFAELFGLQPEQLKTLSNQDLLQRIHPADQQEFREYLELLKTNLSSLDIETRLLHRQHGYQDVFCRCAFHQAEHQPQAELTCVLYNLSEHKS
LDKQLHAEKSFQQVSTSAIYRYDIQHKIDFHTRGFENIFDGLLHRHEQV-DGIWEGLIEDQPKVEASYERILAHHETEVSYRIQ-HDGAIHWILENRTPI
SNPSGAVFAFQSVIQDITQLKQQEEKIFQLAMHDRVTGLPNRTLVLEQMAQWIAT----YSTFSVLTVSYNTLQDINHDFGYSIGDKWLSKTATQLLYHL
PTASYFGHLYGDEYIILFPNVVACSINKICEELLELSKQKIIIDSYEWYPSIAIGVSRFPEDADSAEELVKAASIALGRARAND---YSVYSSTFNIETY
RRHQLQKSIRTSIRRNELFLEYQPKVNAWSGTIIGAEALIRWQHPVWGRIPPNDFIPLSEESEMHILIADWVLEETCRNINQWILAGLPIVPISINVSPK
RLIHGNFAETCQETLNRFGVSPSMLEIEILETDVLFDNSKIQQSLQTLSQMGIKIALDDFGKGYSSISYLQQYPIDTIKIDRQFATTLIQDKKTQSVVRS
VLFMAKEFGMDVVAEGVETMEQLHFLRQLHCTTIQGYLFSKPLPKADFERTMPNC-----
>tr|U6BFI3|U6BFI3_9BACL Diguanylate cyclase OS=Exiguobacterium sp. MH3 GN=U719_13510 PE=4 SV=1
----------------------------------GHVIGVYG-VARD---------------VTR---EKQLEEDVSEIRSQLELTEQVPELVLFYYDLR
SHQIEPSPSLLKFLGLREEQ-SSIEQQRLLERIHPWDFDPLRFEIERMAAGQDQFEQELSLLTSDGSYQLLRLK-AVRRAG--HAHQASIVLYDLSEIDA
ARQQLKMERDIYEAVNAAISQIDLTGRILFHSQGFLHIYEELPKNL-IL-NDTWLSRIRDHDMMRKFMQRLLQGHAGTLQYRLRFPDGRIKWVEDQQIPI
FHSDGSIAYSNSILHDITLQKAYEEQLRQLALRDVVTGLPNRQALIETIESWQAR----TVPFFVLSVSFNRITEINNAFGHGSGDQWLQATAARLNDVK
PDEVFLGHLGGDEYALLVSTDYE-DVTPCAERLLTISTQPISIEPYALFARVSIGISRYPQDSTDAVELLKHSYTALRRSRRDDHSAFHHYASNLDIDYY
RRYRLEQDLHYAIERDQLFLEYQPKVDSWTGKIVGMEALIRWQHPEWGRIPPNDFIPLSEESALHIDIGDWVLEAACRQMNEWSKTGASLVPISINVSPK
RLLIPGFEHQIEQTLTRYALDPALLELEITEAALIMDDPMTSRTLESVSALGVRIALDDFGKGYSSMVYLQRYPIDVIKIDRQFATHIYDDAKAQAIVKS
ILYMANEFNLYVVAEGIETIQQLDTFRMLECPRIQGYLFSRPVPSDVMEGFLIRE-----
>tr|A0A031IGA9|A0A031IGA9_9BACL Diguanylate cyclase OS=Exiguobacterium sp. RIT341 GN=BW42_01918 PE=4 SV=1
----------------------------------EQVIGVYG-IARD---------------ITR---EKQLEEDVSSIRSQLELTEQIPELVIFHFDIH
TQMIEFSPALLHFLGLSETDATTLDQAQLFSRIHPRDFDPLRFEMERLIAGKGRFEMEVSFLTAYGTYQLLRLK-AFHRPH--HPDHLSIVLYDLSEVDE
ARRQLVTEREIYEAVNAAISQIDLSGRILFHSQGFLHIFEELPENL-IL-SREWLERLRDHAAMKQFIGRLVDGQADTIQYRLHFPDGRVKWIEDQQIPV
FQLDGTIAYTNSIMHDITLQKAYEERLRQLALRDAVTHLPNRQALIETIDVWQQK----DHPFFVLTVSFNRIAEINNAFGHGSGDQWLKGTAALLQQTK
SDGMFLGHLGGDEYALLVPTSFK-DVTACAEALLDLSETPISIEPYALFARISVGVSRYPEDSTDAVELLKHSYTALRRSRRENHSTIHHYASNLDIDYY
RRYRLEQDLHYAIERDQLFLEYQPKVDSWTGKIVGLEALIRWQHPEWGRIPPNDFIPLAEESALHVAIGDWVVETACRSMQDWKATGAELVPISVNVSPK
RFLIPGFEHHIERMLSTYDLAPELLELEITEAALIMDDPMTSRTLEYVSRIGVRIALDDFGKGYSSMVYLQRYPIDVIKIDRQFATHITDDAKAQAIVKS
ILYMAGEFNLTVVAEGIETLRQLDTFRTLNCPSIQGYLFSRPVPADVMESFLLRE-----
>tr|B1YMK7|B1YMK7_EXIS2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-1
----------------------------------ALLTGLYG-IVKD---------------LTE---QKELAREYNRLKVNQLLTEQIPGLALVEYRID
TAKFFYSEQVPKLFGLPKKTVQQMGRVEFRNLIHEEDRPVFSQNVDRLYQDFFEYKSIVQARH-TKGWLRILVQVGKSA----DQNIITWVMFDLSEQDK
MEQDLKREKTLCVVVDTALIEYSLKDRYQILTPNFSKIFNVPEEQIHQN-PTYWKQLVEDGTNFLHMMEEVKQGKSIVTFYRIH-TKKGLKWIKDTCYPL
FDTDGQVTGYQSIIKDVTEIKNRQEEIFKLSMMDQVTNMPNREAITETVELLIRQ----NQPFTLLSICLNRINDINQTFGFKMGDAWRAIATDTILRLL
PKEAYLGALFGDDFLVIFPERMTEQVQNFSQRLLQLSKSPIELQDYVFQPRVSIGVSRYPEDAATSSDLIRHSGTAKFRAQKREGSHVELYASNMDIEAV
RQFELLQDMSKGIENNEFYLVYQPKVDSWTGQVVGAEALMRWTHPTWGEISPGEFIPLAEENCLYIPLTDWLIDEVSRYLKSIDY----AIPVSLNVPPK
YFMRKEYMNVFTDAIQRHHVPPYKLELEISETTILEDEDFMAEVFTSLNRIGVAVAFDDFGVGYSSLAYLQTYNVQTIKIDRKFATNIHQNKKSQAIVRS
ILLLAQEFEMSVVIEGIETLDELFMIRELDCKIVQGFLFSRPVPADDMTTLIENG-----
>tr|C6D7W4|C6D7W4_PAESJ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Paenibacillus sp. (strain JDR-2) GN=Pjdr2_4373 PE=4 SV=1
----------------------------------DQITGIIG-ISND---------------ISD---ETRNKQLFQINKQRYESEQNPDAISYFD--LN
GNFMDCNSALENILGYSREELLYSNYSH---LVAEYERDRARFYFDQALQG-TVQSYELVCLHK-GHLVYMKLT-KLPITVDNRIVGIYSIAKDITTKKQ
AENALIEAESLVEKSIVGVYII--KNIILYANPYLIDMLGYKEA--IIG-MSIWD-IVDDYSVVKQNIILYNETDAIRHPLRVLTAEGKLLDVEMYSNRI
MYQ--GSPAVIGTILDVTERKRAEELNAFLAYHDSLTELPNRRKFEEMLENALETAKTARRHFAVMYLDMDRFKYINDSLGHAVGDQLLIAFSKRLQEQI
RETDFAARMGGDEFTVILPHIRDNSAIEVARRIIERTREPFYIEDYELFITTSIGISIYPNDGDDSSTLMKNADSALFRAKDLGKNGYQIFTSSMNVQTY
KVFTLEKDLRKAIQRDELEMYYQPKVNIHTGEIVGAEALIRWNHPEWGLVSPNEFIPISEETGLILSLGNWVKRTVCRQNKEWQLAGLKPIPISINVTAK
RFLSKDFMDAIQQILAETGLEPHYLEIEITESSLLENAETVMHTLDSLNKLGVTISLDDFGTGYSSLSYLKRFKINILKIDRSFIHDLHQGSDDNAIISA
IIQLAQHMNMSVVAEGVETGEQLHILKLLKCDLVQGYLFSRPVQAEAFAQLLKRG-----
>tr|A0A072NTK2|A0A072NTK2_BACAZ PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Bacillus azotoformans MEV2011 GN=M670_00212 PE=4 SV=1
----------------------------------QSVQGIVG-IFRD---------------HN----------EFATIKDHLNRAQQIASIGSWDYFPE
EDIVFWSDEVYSLFGIKEKSSFVPTVGKLMNMVHSEDRERFKTTIDNALLKGIGYETEIRIIQI-GKICTCYVKSECFVNRMGKVTKLTGVMQDVTEKKE
IKDQIQQRENLVQSVDAAVWSYDINKKILFCSDAVYKIFGRSSEEFVKN-VDYWKSSIEDVKTVKQVQHLLNKGEKLNHEYRIIDSSGKIRWVEDRTIPT
LDEEGNLIRLDGLIIDITDRKNYEVQLDHIASHDFLTGLPNRRKFESEFVKAVEMAKRDNRMLSLLIIDLDRFKNVNDALGHAVGDKLLIEVSKRISQVC
GNSSFLARMGGDEFAVIIEDITGDVSIGLSQRIIKKFKEPFFIDDFELYITTSIGITFAPFNGDDAQTLLKNADIAMRRAKEAGRNDYYVYTPSMNIETF
KKYSLEKGLYNALKNNEFYLEYQPKVNPKTGRMEGAEALIRWKHPEWGIVSPGEFIPLAEESNFILNIGDWVVEQVCQTLKEWQEKGLKLVPISVNVSYK
RFTKTDFLKSIVTIVKKTGIHPSFLEFEITERSMIQNEEVVRSVMAKMQALGFKFSLDDFGTGQSSLSNLSTFEIDCIKIDRSFTQNIGGNKRIESIISS
MILLAKDMGMVIVAEGVETEEQLQFLQDRNCHLIQGYLYSRPVGAKQFEQLLQYP-----
>tr|A0A0B6AGL4|A0A0B6AGL4_BACME Diguanylate cyclase domain protein OS=Bacillus megaterium NBRC 15308 = ATCC 14581 GN=BG04_3373 PE=4 SV=1
----------------------------------DQVLGVYA-VCRD---------------YSK---EQEQFAQLSKLETHLKMEQKLANIGSWCYDVM
EDESYWSHQLYKIYGVKHDQRFVPSFKEGARFIHPRDRKRLEDAVGHSLATGESYKIEYTIIRP-GEKRMVFEQADAVVDEKRKVVQLLGVVHDITESKV
ITNELKQKETIYNNLDAGIWSVDVRNKVILCSDAVLNIYGENSAKFLEN-RHLWEAFVEDRPTITKEYIKLMQGKSIRPHYRIQTKKGEIKWVRDHCIPT
CDEHGNLIRIDGIIEDITEEKRYVDKIEYLATHDYLTNLPNRIKFEREVKKSISKMKENDGSLAVFHFGLDRFKHINDTLGHDIGDQLLMNIAKRLKERL
EPTAILARVGEDEFAVCSTSLEQGECKKIAAILFKEIEKEIMIDDFSLYVTASMGISIYPHDGEDAKTLYKNANIAMHRAKELGRSDWQLYSPLMDSAAY
KSYHLEKGLRNALLQDEFFIEYQPKVHAQSGEIDSLEALIRWNHPEWGRVSPGDFIPLAEETNLIIDLGDWVLEHVCKQLQRWKKQGEKVVPVSVNVPSK
RLLKRDFVEYVEKTLAKYEIQPSFIEFEITESSIIQHEEHVKKVMEELKKIGVTFALDDFGTGFSSLSHLKDLEFNVLKIDKTFVQNIGDKGKHQAITKS
LLYLAHALDMKVIAEGVETTEQLDFLLQHDCPFIQGFIFSKPVGKEKIEEYLRVR-----
>tr|D5DY39|D5DY39_BACMQ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Bacillus megaterium (strain ATCC 12872 / QMB1551) GN=BMQ_1088 PE=4
----------------------------------EQVAGVYA-VCRD---------------DSK---EQERSNHISKLETHLKMEQKLANVGSWYYDVR
EDKSYWSPQLYNIYGLNPNQHFTPSLKNVLQFVNRCGQKRLEKAVMEALSTGGSYTIEYTLLRP-GEERTVFEQADALVDEQGNIVQLIGVVHDITESKV
ITNELKQKETIYNNLDAGIWSVDVSNEMIVCSSGVSNIYGEDAAKFLGN-RDLWESFIEDKPAVAKGQHQLQKGKMIRQQYRIYTKTGEMKWVKDRCIPT
LDENGKLMRIDGIVEDITAEKKYMDHVEYLATHDHVTNLPNRRKFERELKNFIRQMKKERDLLAVFYLGLNRFKHINDTLGHDVGDRLLRRIANRLKKCV
TLDVMLARAGEDELAICFLSLAHHECQKLAAALLQEIEKEITIDDFSLCVTASIGISIYPHDGEDAKMLLTNANLAMRRAKEVGRSDWQLYSPLMDSETY
KSYHLEKGLRNALLQDEFFIEYQPKVHTNSREIDSIEALIRWNHPEWGRVSPEDFIPLAEETHLIIELGDWVIQHVCKQLQQWKNQGLQIVPVSINVSSK
HLLKSGFVEHVQQTLAHYNIDPSFIEFEVTESSIIQYEEHVKKVMDELKKIGVTFALDDFGTGFSSLSHLKDFEFNTLKIDKTFIQHATDKGKQQAITKS
ILYLAHALNMKVIAEGVETKEQLAFLQKHECSFIQGYIVSQPAAPQKIAEYLKKP-----
>tr|A0A0C2V8M2|A0A0C2V8M2_9BACL Jeotgalibacillus soli Cunha et al. 2012 strain P9 contig00018, whole genome shotgun sequence OS=Jeotgalibacillus soli Cunha et 
----------------------------------QTIIGVYA-IIRD---------------ITR---QKKMDQKMAKLEKMLEVSQQSGGIGSWEYSLT
TNEIIWSNQMYELFGLVKTTNNTLKIEDFIGLVHVDDRSQMVKAFSESAIRNGTKEVRYRIVLP-GMIRYVQERSSYFEDPQNKKKIIIGTTLDITDRIQ
AETVAKIHKQLCLHLNVAMWTYEIEKRFISYSDRIFNITGYDPNRFVSG-EFDWADYVDDRDIYEKHKEVIEGGHSSEQQYRFIREDGKLIWLRDQMIPV
LNEDRSIKKIVGVITDITENQMLQDQVENLAYFDRVTMLPNRSSLESAIDRFIDESSPAQPIFGLFQLEINRFTSIVETLGNRVCDDLLSQAAERLRALG
HVNVFVSKYGEKSFILLNRDISSEQSKEFAEQMLECFTNAFKIDEYELFSSATIGASTYPMDGETKEELLRNAQIALSRGKDGG-QSFQIFTNNLNAAAY
KAYTLEQDMRKALQDKEFEVYYQPRIDIKTNQIVGAEALIRWQHPLWGTVAPSEFIPIAEETGLIMELGDWVLHTVCRQIQQWKNERISIVPIAINVSPQ
RFLRSNFTGYILKTLASYNLKPSSIEIEITESSLITDIDSVLVILQDLRKAGIRIALDDFGTGYSSLTHLKDLPVDFLKIDQSFIQDIETDEKKAVITNS
IIQICKQIDIEVVAEGVETTDQLDVLVHQKCRYIQGYLFCKPIPENEFKELMSFG-----
>tr|A0A0A2TR50|A0A0A2TR50_9BACI Uncharacterized protein OS=Pontibacillus yanchengensis Y32 GN=N782_16730 PE=4 SV=1
----------------------------------EEIVAVGL-VLED---------------ETQ---MKDVENVLQLKKEHLENSQESAEVGSWDFDVR
TKRFYASSYHYKLFGLDPHSNEEYPYTFFLKHIHTDDRSALDKQLKSALQTGESQTISCRIIRP-HELRNVKTQ-VAPIKEDGKVIRLIGTVFDITDYQD
LKETVDQQSNLTHSMNVGIIAEDTNDKLVFCSAGVQHITGFTPMEYRED-PQLLKKIVDDNERIKGKTQFLHQGQTLHLEYRIVCSNGQKKWITEQTIPT
LNDRHELIAIMRIIIDITEQKDYQHQLEYVSTHDTITGFGNTHHLETNFDVWAK-----QRKFMVLHLKVHRLKQIRDSLGTRIEEEALQAISKRIRDVV
KQGAFIARTSEEEFVLLLDNEAELPDKAHMEHLIKTIREPLNIQGYEFHLPSNIGVSFYPEDGESQEDVLNGARLACSRATEAGKNGYQIYTPSKDILSF
KQFILERDMRPALGNEEFELHYQPRVDLQ-GMIKGAEALIRWNHPRWGMVSPNEFIPIAEEDNFIVEIENWVIQQVCEQLRTWKDKGLTLCPISINISPI
HLYKKDLINTIQQNLDFYELEGHWLELEITETSFLDYSI-MNDLIKNVKELGVGIAIDDFGSGYTSLQQFKVIQRDVVKIDKSFIQELDHEDENNLIVSA
ILFLAHELNIKVVAEGVETYQQFNYLKQKNCEEIQGYYFSKPLPIQDFETMMMKR-----
>tr|U1LZS0|U1LZS0_9BACL Uncharacterized protein OS=Exiguobacterium pavilionensis RW-2 GN=M467_11445 PE=4 SV=1
----------------------------------HVITGLYG-IVKD---------------LTT---QTELRERYNKMIVSRALFERIPGLILVELDLE
TGEFYHSPQTGKLLGLSQRQLDMMEREHFRNLIHEDDRPTFAAAVNRLIQDEFEYETQLRVFNPRQSCLNMIVKVGMSK----DRKAITWAMFDVTNLTS
VEAELTEERQLCEIVDSVIFERYFSKQFKFLTPGFAHVFGYTEEQFNAH-PDYWQKVVDDIPKIHQAREMTLSGKSSTFSYRIF-AKGEVKWIEENREPI
FSESGQVIGLRTLVKDITQLKEQQEEIFRLASLDPITNMPNRESITETVYELTQK----QAPFTLFSLSFNRIAEINHTFGFELGDQWRVVTANRLSRLL
PKDAVLGHLDADNVLIVMPRRMEEDVLALGNKLGTLSKHRFRVDVYDLFARISIGVSRYPDDGAQASELIQRACIAMNRSDRKVGSQLELYSSQMDIESL
KRYELLRDMRGALETKQFYLMYQPKVNAWTGEIIGAEALMRWTHPTWGSISPAEFIPLAEESSLHLDLTNWLIEEVCRYVIILPK----KIPISINVSAK
YLYQEHFERVLEDTLDRFSVPKGYLEVEISETSLLEDAQQITQAFGRLNYLGIPIAFDDFGKGYSSLAYLQAYSAQTIKIDRVFAHHVSQNRKAQGIVRS
LLVIAEEFGMDVVVEGVELMEDLLCLRNFGCQVIQGFIFSRPLKEIDFERALADG-----
>tr|C4L6B7|C4L6B7_EXISA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b) GN=EAT1b_1020
----------------------------------QLIQGVYG-IVKD---------------MSA---EWDTQNRYAIMKVGRELLEQVPGLMVIEVHLA
DGSFSFSSQVSSFLGISRRRLNEMHVEEIRETVHPDDWERLTQAIQTLRIAGADFAMEIRLRHQTFEDLPVTVRGALSV----DRDVITYVIFSTKEQQR
IENELTDKDRVCEASDTAICDYSYTSQIEFATGQFQTIFGYTVKQFNAH-PNYWKVVIDDLERVNQANEQTRHTTPVHLEYRIF-VGKKQKWIQECRQHL
YDETGRVRGFQALIRDVTEVREQEAEVLRLSEFDPMTNIPNRETMFQSITRLIQT----DIAFVLFTVTFNRIGDINRTFGYEYGDEWRIQTAHRLQRMV
PDEAVVGHLDGDTFLVVMPGHHEEWLIQIGEQLARLSKHCFQLEPYTVYPNMQIGVSRYPNDAEDETTLIRRSYMAMGRAGKSGAAPISLYASHMNLDEL
KRFELLRDLPSAIDRNEFYLLYQPKVNAWTGDITGAEALMRWEHPTWGVVSPLDFIPLAEESNLFIRLTDYLIEEVFRFLATLPN----KIPISLNVSPK
YLYHEQLFNTFESASERHDVPLHWIEIEVAETSQLDASHHIMSVFSSLRALGIQLALDDFGKGYSSLAYLQQFQVNTIKIDRIFGHGVSENKQARAIIHS
LVVLAKEFGLDVVVEGIEQMEDLLLLRQIGCKTIQGYLFSPPVREDAFLQMMESG-----
>tr|D7WUJ7|D7WUJ7_9BACI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Lysinibacillus fusiformis ZC1 GN=BFZC1_14058 PE=4 SV=1
----------------------------------NQAEGLYL-IIED---------------MST---YSAMKHQLMLHEKHLNYAQHIAAVGSWEYFIQ
HDKLFCSDNFYHIFGFARSDNDGI-DHV-FQFIHPHDYERTYDAFND-ARKGTNFDSDFRIYHGTNELRFLQAAAEVIW-KDDKPFKMIGVVKDETAFKL
LEKTLNDTLSIFDNLDAGIWMRDSRGNMLFASKGLEGILGIPLARLYED-SEVWINMIAHREEVLAYTDHLASGKSYQVIYRILTGENQTKWLLEQIVPR
VDQEGEVNHIFGLVTDITKEIEREKKLNYLVYYDELTGLPNRLSLHDKVDTLCLA----GEPFALLYISINRFHILNNALGTKIGDELLRTVTNYFSTLT
DDHSYMARLDNQHFIIVMKKYGSQHIYALASRLLKTFDTPFSIKDYRLHLSASIGIAFYPEEGLSRNILLENAYSALCYAQQQGRNRFHIYAFTEDITSY
KQYVLDRDMRQAMLNEEFELYFQPLVEPQKGIINGAEALIRWHHKEWGLVSPGEFIPLAEENHMIHIITDWVIKKACALLQHWKQQGHVLRTISIKISPI
RLMKKGFIQFVQEQLQVNSIDAHYLQFEISESTILKNSTSVMTVLEELQDMGVKIAIGDFGTGYSSLESLRTFQPTTLHIYEAFIREIRHDRIENGLISA
TIYLAKMLGIQVVAKGVESYEQFIFLKQQECDYLQGSIYTKAVPAKAFEKMLTQG-----
>tr|F2F4R6|F2F4R6_SOLSS Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Solibacillus silvestris (strai
-----------------------------------DIVGIYL-IITD---------------NTD---KTELKQELMLWENHLNYAQQIAEIGSWEYVFN
EDKLICSKNFYNMLGLDYQKYISI-NKP-FKQIHPEDLDISLQYLKKAIYDGENYTHKVRVYHRTKELKHLKVHAEVFF-EEGKPAKIFGIIKDETYQTL
LKKKLMEQNSIFDNLTSGIWMREKGGKFLFASKGLESILEIPLSTLYED-SKAWYNMIVHLPELANGKKKMINGQSFQWIYRINSGSGTTKWLLEEVVPR
LDDHGQITNIFGLVTDITYEIEKEHTINYLSNYDNLTGLPNQQSLFKKIDLMCES----DDPYAILYFDLDRFNIINDSLGYFIGDETLKFTAQRLEKIM
PKESYLARLSSNDFIMIIKNYNTKEVLQYAKKVIKKIREPFTIQDYELNISTSIGITFYPEEGREKLTLLKNAHTALYKAKKDGKNTYKLSSDDEDLSSY
KKYALDRDMRKAISNEEFELHFQPQVETGNGSLCGAEALIRWNHKEWGLVSPGEFIPMAEENHMINGITDWVIEKVCQLLKEWKEKGLPIIPIAINVPPI
RFMKKGLFQHVKTQLENYGIDPFYLEFEITEDTLLNIESSVYSTIQSLKDLGIRIAVDDFGTGYASLASIRKFKPNKIKIDKIFIDNINNEDVDNGIICA
TLNLAKSLEMNVVAEGVEEFEQLKFLKKNDCDVIQGYLFSKPVKKEMFEHIMKAG-----
>tr|W9AP77|W9AP77_9BACI Bacteriophytochrome cph2 OS=Oceanobacillus picturae GN=cph2_2 PE=4 SV=1
----------------------------------DKINGVYI-IIED---------------TSE---IKELAEELKKHKTHLLAAQKVASVGSWEYIIP
DDDLFCSPSFYEIFGLPKSEDVTM-NKLLLRYIHPDDRDKTSSIYKLALKEGKSYKVDYRIYHEENKLRYLRVQAEVLW-QNNAPWKLIGVVMDYTEEKN
LEIELRNTLHMFNNLDGGIWMKELTNKVTLASEQLVDLLQIPLEKIYED-PAVWENIIDFRDKVFQKQDQLMAGKPIKHKYKIICGDHSTKWVYDQTIPW
VNDDGRITHLFGVLVDITDEKQMQDHLRYISTHDEITDLPNQQSLHETLDKLINE----DQPFAILHLDLDRFNVINHSLGYQVGDMVIHQLAERLREIV
PSTGYLARLNNNDFVMILQQYNGEEVFELAQKTIQSIGKALMVKDYELHITTSVGISFYPEDGTSKLRLLENAYSALYHAKQQGSNNYQFYSFSRDISSY
KKFLLEKDMRRAIVNEEFELYYQPQVEAATGRIKGAEALIRWNHRDWGMVPPNEFIPLAEENHLIHHISDWVIRKTCAQLWRWREAGYPVIPISINLSPI
RLLKRGLVELVEGQLALYKIPASMLEIEITESSLLKNEIGVLKTLEELRKLGIKIAIDDFGTGYASLNYLHEFEADIIKIDQIFIQNITSANKDAAIVSA
VMHLAKEIGMQIVAEGVEEKAQYEFLKERNCDLIQGYYFSKPVPLPDFEELLHEG-----
>tr|A0A0A3HQR8|A0A0A3HQR8_9BACI Uncharacterized protein OS=Lysinibacillus sinduriensis BLB-1 = JCM 15800 GN=CD33_14425 PE=4 SV=1
----------------------------------KEVLFIYG-MAQD---------------ITG---YVQHEQKIQNILNRLELAQSCGNIGSWDYDIE
KDEIYWSNQLYIICGREIEEGYTPNIAEGLEYVHPADREKYLNYFNDIIENGAGNTLEYRLLRG-NTIRYVYERISVVKDPTGKPSRLICNTQDITDRKL
AEKELLESKHIFDNLSPGIRSYDTNDRITLVTAGIELILGYPTEMFYQK-GS-LEDLIEDKLHYSKSYAEVLKGKGFDIQYRVFHNNGDIIWVHDKTLPV
LNDHGQVIRVDGIISNITEHKNYEDKIHQLAFYDNLTNLPNSILFNQKVEHLIGQA----KPFTVLFLDLDRFRNINNTLGHEIGDIVLKQFCERVNNLL
TGTFLFSRLGGDEFGLILWEYDENYPELIAKKVIDHLSDPFLVREFELYVSASIGSSEFPTNGKTAVEVLKNTSSAVLRAKQNGKNSYHIYSPTLNISSF
KTFELERDLRKSIVNDELVLHFQPRVDAQTGKLLGAEALVRWQHPVWGLVSPGEFIPIAEESGYINEISDWVFKEVCRSIDRWRKGNLQIVPISINITSQ
RFLKSDWVTLILSLLNKYKIEASLIEFEITETTLIEHEKEVEFAIQFLKELGIKIALDDFGTGYSSLAHISDFPIDTIKIDKSFTQLIKQDEKMDIIIIS
LIFMAKGMGMNLVAEGVETIEQLEFLKEQGCKEIQGYLFSEAVPEAEFQLFLKNI-----
>tr|E5WG17|E5WG17_9BACI Uncharacterized protein OS=Bacillus sp. 2_A_57_CT2 GN=HMPREF1013_01392 PE=4 SV=1
------------------------------------SQDGEN-TTKD---------------TAE---YNSQQMELTKIKNNLNQAQKIANIGSLEYDVE
NDRGFWSDQLFRIFGLKSQKGFFPDYRMYLSYLHPDDRPAFEDQFQKLLKEMNSVDLICRIIRQ-GEERYIHQRANYFAEDSGSPKI-IATIQDITEKRR
MEEKLYENEQIYENLDVGIYSADLERKVFHFSRGVEGIFGYTADELIDN-FDLWDEVIDDLQSLEANRVNLIHGKSIRCQYRIFNKSGELRWVNDHSIPY
LDERGELIRVDGFVTDITEQKRLEEKMRHMAFYDHLTDLPNRRYFDQKLQSLVKDN--EKHRFAVLFFDLERLKQINDTFGHSAGDELLRLVAKRIREKL
NVTFFSARISGDQFAVIKEHIQEEDPAQLGDCIYQIFSEPFHIESFELKITPSIGISIYPNNGVSAEEMVRNTETSLYHAKQKGKNRFQVYHPSMDIESY
KLFTLEQDMRKALVNDEFILEYQPRVDTKTGKILSAEALLRWSHPEWGRVSPLEFIPVAEESGFIINIGEYVIRKVCRQLFDWKEKGLSIVPISVNISPL
SFLKNSLVSMIKEALDEYHLEAELIEIELTESSLINYSENVISVLKELGSMGVKIALDDFGTGYSSITQLKNYKFDVLKIDKTFIQAMDKTAEDAIITAN
LIQLAHGLNMKVVAEGVETFEQFYSLRKNECDQIQGYLFSKPIPPSSFEQKLLIG-----
>tr|U5L5Q6|U5L5Q6_9BACI Uncharacterized protein OS=Bacillus infantis NRRL B-14911 GN=N288_03720 PE=4 SV=1
----------------------------------NQITGVFG-IAKD---------------ITE---LAEKERKLQKAEERLNLAQKTANFGYWDYYFK
EDSAYWSEHMYEMFGVS-KDEFIPSFDYYKDFIHPEDLAPFLKNYHASLEEKTPADLEYRIIRK-GQVRRLHHQSTLILDGDGCPERAVGISRDVTEQRE
IEDRLAENTSFYNNSDVGVWSLDPGKKVLICSNAILAIYGYTKKELYRD-PRIWNRSIDDVQEVINNQNKISEGNIIRQQYRIITRDGKLKWVSDHLIPI
YDEKGRLIRLDGIVADITAQKQAEAQMEFLAYHDYMTGLPNRRLFDQTLNGLFEGK--NPEKFAIMYLDLDRFKHINDTLGHPIGDQVLKEAADRITASI
RKGDFASRMGGDEFAIIARNVESEDASRLAAKITGTIQKPYEIEGYELFITASIGISLYPNNGSTPEELARNADAALYHAKQMGKSSHQVYNASMNIESF
KKYCLERDMRNALKDDQFYVEFQPKIEPRTHKLAGAEALLRWNHPDWGIVSPMEFIPVAEESGLIVEIGDWVIENVIAKMEEWQKGGLSLVPISINVSGQ
RFYKNNLAEMIGDLCQKHGISPKLLELELTESSLIHYSDQVLQELEKLGQLKIKLSLDDFGTGFSSLTHLRKFRFNTLKIDKSFTKNIISNLEDATITSS
LIDMAHGLNMKVVAEGVEEFEQLDFLKKKGCDEIQGFLFSRPVSGIVFRDFLKEG-----
>tr|A6CIZ8|A6CIZ8_9BACI Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Bacillus sp. SG-1 GN=BSG1_04660 PE=4 SV=1
----------------------------------KGDFIISG-VITD---------------ISA---LAIQKEHAESLEIRLNTAQQLADIGTWEYDIA
NDECSLSYKSYEMLGMP--YGITPTFQMLLETAHPEDKDIFLNEFVSALNEKRNFHCQNRIIRS-GAERILAHFGEVILDDNQKPVKYIGTTYDITEQKI
IEDKLAETEKISNSLDVGIWSMDVKNQYIFVSKGFETICGYSAEDFKQG-LLQWEDLIEDLHLFEQRKEALHTGKVPKQQYRIVHKNGNTKWVQDELITT
FNTKGDLVRIEGILSDITEQKEAEEKVNYIAHHDYLTDLPNRRKFEQELQKFIEQSKMANQEFGVMYIDMDGFKRVNDTLGHAIGDKLLVEISTRLLDCV
PQNDFVARIGGDEFSVLIDKMHSEQSTTIAKKIVAALEVPYKIHGYELFVTASVGVAAYPQDGHDAQTILQKADKALYRAKEMGKNNYQIYNSSMNIEAY
KLYSLENDLRRAVKNKELYFHYQPKVDAQTEKLVGAEALIRWEHPEWGQVSPAEFIPLAEENDLIFKVTSWTFQTICTQIKNWTDRNLPLVPISINVSPK
IFIKNEWQEELIYIINNSNVDPRLIELEITEQALIKNEESFSAGIEKLKQLGVKISLDDFGTGYSSLLYLKKFKLDTVKIDKSFVDDILKG--KPTITKA
IINMAHEFDMTVIAEGVETRAQQSFLQKQDCDQIQGYLYSKPILPEDLEELFRNP-----
>tr|U0ZKI2|U0ZKI2_9NEIS Diguanylate cyclase OS=Pseudogulbenkiania ferrooxidans EGD-HP2 GN=O166_10335 PE=4 SV=1
--------------------------------------------------------------------QHRAEQELRDRERQLARVIAGSDQGFWDWNLK
TNRFQISPRWESMLGYGPGEMHITADSWY-EHLHPDDVALRDSIQRNLRGELNSHEVEVRCRTRGGDWRWILSRGRVVEREQGEPLMMSGTHTDITERKV
FEQTQKEAAAVFDSSYEGILMVNPDGVITKVNNAFSRITGYSAEEAIGQKPSLLSSGKQPISFYEELWNSVKGHDFWRGELWNRRKNGELYAELLSISVV
RDEQGEVQHYIGIFSDISQLKQHEAELDRVAHYDPLTGVPNRRLLSDRLRQAIVRANRSGKSCAVCFLDLDGFKAVNDKYGHAVGDQLLVAVSNNLKAIL
RGDDTLARLGGDEFVVLLSEVGGEECMLVLDRVLATASQPMPVGDAAVSVTASIGVSLYPQDNVDPDTLLRHADQAMYLAKDAGKNRYQLFDPENDRKAQ
EHRQFLELLRQALVRDEFTLFYQPVVDLQSGEIISVEALIRWRHPRRGLLAPAEFLPHLSGNELEAAFGLWVLDAALSQVSRWAEAGFH-VKISTNVSTN
YLLRADFSQQLSTVLGRYNVPPWHLELEIVESAS-GDVEQTIRVLQRCRELGVHFALDDFGTGHASLTHLRRLSVDTLKIDNSFVHDMIDSQDDRRIVEG
VIELASIFARKAIAEGVETMEHAALLRRLGCRYAQGFGIARPMEADKVVDWCS-------
>tr|S6AD24|S6AD24_9PROT Response regulator receiver modulated PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Sulfuricella denitrificans skB26 GN=SCD_n02290 PE=4 SV=1
--------------------------------------------------------------------KLRHQALIQRSEQQTRLLLESAAEAIYGVNME
GLITFANPACLHMLGYEHEELLGRH---AHDLFHHSHADGKCRAYEAYADQGVHVDNE-VFWRKDGTAFPVEYWSHPIH-HEGRVEGSVITFMDITERKQ
AEQQLRLAAQVFEGTQEAIFITDAQNHIVSVNQAFIEITGYDRTEAIGQSPALLKSGRHSAEFFHGMMNSIRRSGHWQGEIWNKRKNGEIYPAWMAISTV
CNEQGDITHYVAIYTDISELKRSENQLERQANYDELTGLANRNLFQDRLNQALIFSRRHDYGLAILFIDLDNFKNINDSLGHDTGDALLAQVATRLTGSV
REGDTVARHGGDEFVLLLSEIRVDDVSAVTQKLLKAMSAPFNLNDRELHVTCSIGIASYPKDGEDKQTLLKNADAAMYRAKELGRNNAQYYAEEMNIKAM
ERLTLENCLYQALERNEFLLHYQPQVDLRTGEITGMEALVRWQHPELGLVSPSMFIPVVEDSGMIISLGEWVLRTACLQNKAWQLAGLKHISVAVNLSAR
QFRQPNLVEMVTGILRESGLDPSHLDLEVTESLVMQNVEATIATLGRLKAMGIKLSIDDFGTGYSSLNYLKRFPIHTLKIDKTFINDITTDPNDAAIAKT
IISMAHELGLMVIAEGVETEEQRSFLHLRNCDEMQGYLFSRPVSAEEFEILLRER-----
>tr|L0GT57|L0GT57_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thioflavicoccus mobilis 8321 GN=Thimo_0107 PE=4 SV=1
------------------------------------------------------------------------LAELKAARERYQELFDHAALGYLVLEET
GLIRRASETALALLKRDRRSVEGRQ---VQTLCTTDSVKGIEAHLERL-AAGRQDVCEVRLLGRGGPPIDARIET--CRVEGPGGGPLRAALVDLTDQRL
VEARLAIVASVVEHTAEGVMILDAERRVVSVNPAFTAITGYAAHEVMGKPPRVLRDRPNDSEQFRRIREQLEMNGRWQGEIWSRRKGGERYLEHLNLNEI
RDESGMLTNYVGLFTDVSRQRQVKKELYDLAYYDSLTGLSNRHHLLAQLGSALYASVREGNLVCLLYLDLDRFTAINDGLGHGAGDQLLRFVARLLQECV
RKSDTVARLASDEFAVILPHVTSDDAAKVANKVLRARAIPFVHEGNEYLVSASLGIALFPDDAQDSKGLLHCADIAAHRTKAAGGNGYNLYAVGMSDELE
ERHQLESDLRRAIARRELALQFQPQVRLRDGQIVGCEALLRWDGEGSGKVPPERFIPIAEDSGLIVPLGEWVLNEVLKQINEWRPHFGDDFRIALNISGA
QLHPLRSARLFNRLLEAPVADRRLLELELTESTLMGPPEAMGEALSRIGLLGLGIAVDDFGTSYSLVNLLKRQPITRIKIDISLIKNVGDDAVDAAIASA
IVTMAHALGIKTVAEGVETQEQLAFLLALGCDEAQGYLFSPPLDPPAMLGRLTAR-----
>tr|W0SI89|W0SI89_9RHOO PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_01836 PE=4
------------------------------------------------------------------------FAEYHDIKEQFDMLSGMADVGVVVTDGN
GTILEASPATTEMLGHEPRLVHGCP---LALLIAEADRKTIAD----L-VLTGREATDVRVTSIVGKALSGRV----LRVPDPEQGYRITWLLRMAEAGD
IGQRGALFSQLYARSTNGILVTDAWGTILSANPAFTKITGYTEAEVLGKTPRLLSSGRHDREFFDRMWQSLAENGEWQGEIWNRRKNGEIYLEWLHIIAT
SVDRSGPVDYIAMFYDVGHFHADRDRIYELANHDSLTGLPNRALCKDRLQQVIAQARRVGGSVGLLFIDLDRFKEINDTLGHAVGDQVLMDFSWRLVHAV
RDTDTAARLGGDEFVVIAPGLANDDIRVVAQKIIDSLAVPFVIDGRDLYVGASVGVAVYPTHGDSADELLRQADTAMYAAKGGGGNACHFFDDTLERRRA
QRMDIEAGLRRALAQGQLRLVYQPQVAAGDGRLVGVEALLRWDRPGHGVVPPDQFIPLAEATGLILPIGEWVLRAACLQLAAWRDAGLPPLRMAVNVAAR
QLNDVDFVSRVVAVLEETETPPGNLELEITESQLMEKMHTGLDNLKRLRELGVAVAVDDFGTGYSSLGRVQSLPIDRIKIDKSFVADLNVSGDSYAIAHA
IVAMALALRLEVIAEGVEHAEQAHLLAGIQCHEFQGYLYGEPQPPEAIAAMLQQL-----
>tr|A0A095XX18|A0A095XX18_9GAMM Uncharacterized protein OS=Haliea rubra DSM 19751 GN=HRUBRA_01100 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------------AVDSNEPTEFSYAL-ELLGEKRWFEARVAQ--TGDGQ--RVACIVRNISERMR
AREELKELEQAVASTEDQLAAIDRDNRYLMANEAYASFFGYQPEELIGHRVEELFSEEALNNKIAPALARCLAGETVSFEEWRQPAVGDQ-RCFNVVYTP
LYNGEGALGVLVSAHDITALQSAQAQLERIAHHDPLTGLPNRILLDIILQRSLKQANRDGGQVAVMFIDLDRFKTINDSLGHAAGDEVLRQASRRLLGAL
RESDSLARVGGDEFVAVLAGVQDANLSRVASKLMDAVSRPFELGGEQAQLSCSIGISLFPADARSADELLTNADTAMYEAKEQGRNDWRFYTAAMTAEAA
EYLTLVENLRAALDGKGLDLVFHPEFDLTSGSVIAIEALTRWQDPVLGAVSPERFIHAAEKAGIVRQLDFQSLDAACAHFASWQAQDIAPLRLGMNVSPK
TLNHVDTPARIEATLLLHGLAPDQLELEIHERALLEDPERTRSSLEALAALGIGLVVDGFGSSTLGLRYLQDLHVRTLKVDGSYLKDVSGA-DGQRMARA
MIAVSQALGLDVVLAGVENIEQATFLKGEPGVHAQGYYLARPLPAEEVADFLRG------
>tr|A4A7X6|A4A7X6_9GAMM PAS domain protein S-box/diguanylate cyclase (GGDEF) domain protein OS=Congregibacter litoralis KT71 GN=KT71_14414 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------------AQQGNR-----------VRFQQWRETPEAP--YSDTQVRGVAVSIHDITPLHE
AE----KLREVFSSSAEAVMMTELDGSIIDVNNAFTEITGYARNEAIGETPEIISSDQHSPQFFQEMFRIIDAQGRWQGEVWNRRKNGDHFPCLLTVSAV
RDEKSRVTGYVASFSDITTIKQNEHRLELLARQDPLTGLPNRTHLRHTLDSRLARAAPGNRSTTILFIDLDQFKDVNDSLGHSAGDELLKVCSSRLLDSL
RDDDILARVGGDEFVALLFDVPGENVSTIASKLIAVLEEPIAIGGETVRVSASIGICRYPEDGADTETLLRNADTAMYAAKKAGRGTWECYSQAMTDVAT
RHLLLSGAFREALTANDLEIVYQPKYDADSLALTGFEALSRWTSPDFGNVSPEEFIAIAENNGLIVELDYKVLGGVCAQLSRWRAARLLPPKIAVNVSGR
TLQQADFYQRLRDILEHHDVSGESLELELTETALLPQPEKQAGVLDQIRALGLTISIDDFGTGYSSLSYLQRLPVATLKIDASFVRELSVSKDADAIAEA
IIAMARALDMGIVAEGVESEQQARFLRERGPMSVQGFLYSKAVSAQAATDMLPG------
>tr|G2DEH3|G2DEH3_9GAMM Putative signaling protein OS=endosymbiont of Riftia pachyptila (vent Ph05) GN=Rifp1Sym_ca00130 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------EENQPFSVDHRIVWRNGTVRWIHQEADR--DADG-FDQMLGVVIDITDRKL
AEQSL-ERNHVINGISDPLRVIDQEMGVMLMNGCYQSCQGMKPL--CDEYPDGM--------PACPLKRVIKT-KQPQTETLITLDDGEQ-RTYESSFSP
LLEEKIMYGVVETSRDITEHLEQDDHVVQLTYLDQLTGLPNRLLFMDRLRQGLSISRRDNRSLAVLYIDLDRFKQINESFGHEFGDLILQDVARRLQGQL
REGDTLARFSGDEFVAVTGNLGQEHAGILAQKLLQGFDEPFFVKDQKFYVTASIGVSIFPQDGQDPEALMREANTALFQAKDEGRNSFQFYRDEMTVQAF
EHVLMENNLRNALMEQQFEIYYQPQVSFDTGEVVGAEALIRWNFPEMGMVSPAKFIPLAEDTGLILPIGEWVTRTTCQQIVDWLKRGIPVPRIAINLSPK
QFNDKHLLENIIRILDETGCPSEQIEFEVTEGQIMERSERAIGVLEALRKNGITVAIDDFGTGYSSLSQLKQLPLNKLKIDHSFVRDLPDDMDSRAIAEA
IIGMGRSLGLSVTAEGIENQAQAEFLQSAGCTQAQGFLYQRPVPAAEFEKFLLD------
>tr|A0L9T5|A0L9T5_MAGSM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Magnetococcus sp. (strain MC-1) GN=Mmc1_2227 PE=4 SV=1
---------------------------------------------------------------------------------DLENAQSVAKIGSWHWDMQ
KDNLHWSKELVRLLGLEGDTSHASY-STYLELIHPDDRAKINRQM-AAVTRGDRFEADHRICHKSGELLHIHALGIVSRDSRGVPSQMVGTLQDVTRRKM
AEEGLVLAKMIFDNAGEAIVITDAQGDITDVNPAYQRIMGYTRDEIVGQNPSILKSGRHDEQFYEQMWNEMLSEGHWQGEIWDRRKSGEIFPKWLTIDAI
RDEQGVISNFVGLFMDITQQKETEEQLEKLAYYDPLTELPNRALFRDRLEQEMRLSARGGKSLGLFFIDLDRFKYVNDSLGHDKGDDLLIQVAGRIKHHL
RTSDTVARLGGDEFTVILPGIEQNDVARIAGAIVKSLGEVFVLQGHEVFIGGSIGIAMHPDDGEDYETLTKHADTAMYRAKEEGRGTYKFFTSDMNEING
RRLSLERALRQAVECNQLTLHYQPKVDVKQCRITGMEALVRWNHPEQGLVSPVDFIPIAEETGLIITIGEWVMQQACMDAKRLARSSRHPLQVAINLSAK
QFQDALLVAKLERSLQQSGLAPELLEVEITESLAMGDVNRTIEQIGELRALGVKVSIDDFGTGYSSLSYLKKLPLNALKIDKSFIQDLYLDSDDTAIVSS
ILSMASALGLSVVAEGVENQAQIHFLCEKECPTIQGYFFSKPLPFEAFEKFLLD------
>tr|I1YFD1|I1YFD1_METFJ Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Methylophaga frappieri (strain ATCC BAA-2
----------------------------------------FTDVARDFNRFAENTSQ----LITA---LDDARARLQSRDDYLTALLNSVPEAILTLNAT
GQIMTTNPAASNVFKTTETLLKGTR---LQDFLSNSSQS-LSEMMM-NQEREREFS--GIDAQGKLKTYWISLSRVES-----EKMAWVAVVSDISSWKQ
AKHDLQQITAIFENALVGIALL-RGHHLVRVNQKFETLFASNRAHLEAQNERVLHIDGAYARFVEQAYPTLEKGESFQTQIEMQRLNGQTFWCALSGQAV
AGSDAAAGGSIWLFEDVSIQRQNEERLTRLAHEDSLTGLPNRGVFNDRLEHAIHKLQRKPGRLAVLFIDLDHFKHINDSLGHKAGDNLLCDVGRRIRSCV
RESDTLARLGGDEFTVVLEDIDSQFVGRVADKILAATTLPFMIDNIEVNISPSIGISLYPADGRDADILVRNADAAMYHAKNSGRNNYQFYSAEMNAEAS
NRLALETSLRHAVEHKEFYLELQPQIDLVSGEVSGAEALLRWHSEQWGQVSPAVFIPVLEDTGLIGTVGEWVLRQACQLFMMHRDQLPPDFIIAVNLSGR
QFKGGRLLGYVRQLLNEIDMPASNLELEITESLLMDNTALAIETLRELSHLGVKLAIDDFGTGYSSLSYLKQFPLNVLKVDRTFISDITTDKDDAAIVGA
ILAMADSLGLSVVAEGVETAEQLALLKQKHCQRAQGFYFSKSLNIDDFMRYVREH-----
>tr|I1XIF8|I1XIF8_METNJ Methylophaga nitratireducenticrescens strain JAM1, complete genome OS=Methylophaga nitratireducenticrescens (strain ATCC BAA-24
----------------------------------------FNLLASDFNVFAAQTQS----LIAK---LDETKHSLEVRETHIRAILNGVPEAILALQAD
GTISSCNPAAEKILQASECQLAGQK---ILRFFAPSERS-LTDINR-IQKDNREFE--GVNWHGDVFSMWVSLSPLSEF----DDDIWVCVISDISSWKR
TKLALVQTSAILENAMVGIAFI-KNRHIIRVNNKFEQLFLFAREDIEGQSTLCLHPEEAFERFGEQAYNTLSEAENFEAQVEMIRANGEKFWCAVAGQII
DP-VNPAAGSIWLYEDVTHQRQNEERLTRLASSDILTGLPNRGVFKDRLEHAIHKAKRQNGRLAVFFLDLDHFKHINDSLGHKAGDILLCEVARRIRSCV
RDSDTVARLGGDEFTVILEDVNSRYVGKVAEKILNTTALPYMLDNIEVNISPSIGISLYPADGRDVDMLVRNADAAMYYAKSSGRNNFQFYSSEMNAQAS
QRLAMETSLRRAVELQEFYLQFQPQIDLETGRVAGAEVLLRWHTEQWGDVSPAIFVPVLEDTGLINTVGEWVLKKTCEAFMANRNYLPDDFLIAVNLSGR
QFKGNLLINFVRNLLEQTGMPAKNLELEITESLLMENTEQAVQTLRELSLLGITLAIDDFGTGYSSLSYLKQFPLNVLKIDRTFVRDVTEDSDDAAIVNA
ILAMSKSLALEVVAEGVETAEQLAFLRKSQCKRAQGFYFSKAINLDELMDYIKAT-----
>tr|M7PI20|M7PI20_9GAMM Diguanylate cyclase/phosphodiesterase OS=Methylophaga lonarensis MPL GN=MPL1_04477 PE=4 SV=1
----------------------------------------FNLLAKDFNQFAENNQT----LIND---LAEAKHSLQVREQHIRAILNGVPEAILTLNNE
GMITACNPAVEKVLHATEQQLVGQP---LSRFLDGTAAM-PEKLHL-LQKKHREFD--GYDFNGDVISMWLSLSPVSSI----DGDLWVCVISDITDWKE
TRLQLQQRTAILENAMVGIAFI-KDRHLIRVNHKFEQLFGCSRAQIEGESAMYLHPLEAFVQFGENAYSALAQGEDFEAQVEMVRMSGQRFWCAVAGKAI
DP-ESPAEGSIWLFEDVTKQRENEERLTRLANADVLTGLPNRAVFNDRLEHAIHKAHRNSGRLAVFFLDLDHFKHINDSLGHKVGDMLLCEVAKRIRSCV
REGDTVARLGGDEFTVILEDVRSQYVGKVAEKILNTAALPYLLDGTEVNISPSIGISLYPADGRDVDMLIRNADAAMYHAKNSGRNNFQFYSADMNAEAA
QRLALETSLRRAVEQNEFYLHFQPQIDLDSGRISGAEVLLRWHTEHWGEVSPSRFVPLLEDTGLINTVGEWVLRETCRQFVESSADLPDDFVMAVNLSGR
QFKGGHLARYIQNLLLESGMSAKNLELEITESLLMDDTELAIDTLRQLSALGVTLAIDDFGTGYSSLSYLKQFPLNVLKIDRTFVSDVTDDKDDAAIVNA
ILAMSESLDLEVVAEGVETAEQLAFLRAQNCKRAQGYLFSRPVPIEELMQLVDKR-----
>tr|A0A0A0BED3|A0A0A0BED3_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Methylophaga thiooxydans GN=LP43_2372 PE=
----------------------------------------VLRLAKDFTFFAGNTEQ----LITE---LAQAKESLENREQHILAILNGVPEAILTLDMN
GKIEQTNPAAERIFLATENALVGEN---IFRFFAHLETS-FNDIIE-QAAEGKEFD--GQRYDGSDVSMVLSLSQIRAA----KGEVWVCVITDISTRKR
TELQLQQTTAILDNAMVGIAFL-RDRQFVRVNEKFEELFGYTRDDIEGQSTQCLYLADAYVQFGKEAYHQLISGDNYEAQLEMVRKDGQVFWCGISGKAI
DA-GSPKAGTIWLFEDITIQRQNEEHLTRLASIDGLTGLPNRAVFIDRVEHAIHKSMRNSGRLAVFFLDLDHFKHINDSLGHKAGDILLTEVAGRIKACV
REGDTVARLGGDEFTLLLEDVRSEYVGKVAEKVIKSMTQPYQIENTEVNISPSIGISLYPADGRDVDMLVRNADAAMYHAKKVGRNNFQFYSAEMNAEAA
KRLAMETALRRAVEQQDLHLHYQPQVNLQTGKLVGAEVLLRWQSEQWGNVSPAEFVPMLEDTGMITQVGEWILRQACATYLEWSERLPDKFMMAVNLSGR
QFKGGTLAGFIRRLLDETGMPAAHLELEITESMLMDDTELATITLAELSAMNISLAIDDFGTGYSSLSYLKQFPLNVLKIDSSFVRDVTSDKDDAAIVGA
IMAMSNSLGLKVVAEGVETAEQRQYLLRHDCRLAQGFLFSKAVDKDKFSTLIDQA-----
>tr|F5SV80|F5SV80_9GAMM Putative signal transduction protein containing a membrane domain, an EAL and a GGDEF domain containing protein OS=Methylophaga
----------------------------------------VSMLARDLNHFAEVTQN----LIAD---YSKAKVTMQHKQQQLRAILNGVPEAILSLSEE
GYIIDINPAGATMFGGTIKEIVGKH---LFHFFAEKHKS-IDDLEH-DDESNGEYE--GIRIDGSAFSLWISVSRILSG---NDEFVWVCVIADITKWKQ
TNQQLHQMTTILENAMVGIAFI-RDRKVVRVNQKFEELFQYSREEIEGQKTQFIYPQVAYEQFGEHAAHYLSVGESYEAQLELVRKNGEKFWCAMAGKSI
EA-EAPQNGSIWLFEDITTQRQNEERLTNLASVDSLTGLPNRNVFNDRLEHAIHKAHRDSGRLAVCFLDLDHFKHINDSLGHKAGDSLLREVAIRIKKTI
REGDTVARLGGDEFTVILEDIRSQYVGKVAEKIIDAMSQPYIIDNVEISISPSIGISLYPADGRDVDMLIRNADAAMYHAKKTGRNNFQFYSVDMNAQAS
LRLAMETALRRAVEQEEFFIHLQPQVEIETGKMNGAEVLLRWNSTQWGLVSPAEFIPILEDTGLIESVGEWVLTQACNSFLKVKDKLADDFKLAVNLSGR
QFKGGNLASRIRYILAETGMPTKNLELEITETMLMEDPELATLTLSELSQMGISLAIDDFGTGYSSLSYLKQFPLNVLKIDSSFIRDVTTDKDDAAIVNA
IMAMSESLGLMVVAEGVETMEQLDYLKQHTCQGAQGYLFSKPVSEDQFYELAQKD-----
>tr|S6AJ14|S6AJ14_9PROT Sensor diguanylate cyclase/phosphodiesterase, PAS, PAS and PAS domain-containing OS=Sulfuricella denitrificans skB26 GN=SCD_n02
----------------------------------------IGELVLTFNTTAAQTAE----LIEE---LDNRAR----ENAMLAAILEATSDFVGTASPE
GHCLFLNRAGRKILGLAEDEDLGHT---IADYYPPEIAI-THTAHP-AAVREGSWA--GESLLRSRTGQEIPVSQVTIA---HKVNYYSSIMRDTTHFKM
LEQRLQSSLLKLMQELPNPIWRARDNKCNYFNRAWLEFTGRTLEQELGDWADGVHP--DLERCLSTYLSAFKRREPFTMEYRLRHRDGSYHWLLDHGTPF
TD-DGEFAGYLGACYDIEERMQYQSQLEYQSQHDELTGLPNRNLLADRINQVISRVRRHDSLVGVLFLDLDNFKVINDSLGHEVGDHIIKAVSERLVAAV
REGDTVARYGGDEFVVVLADMAQEDVVSTTRKLMAEMTAPFSVDGRNIVVTASLGVAICPRDGEDQVILLRNADTALYRAKEAGRNTFQFYAAEMNQRLL
ARLNLERDLRQAVERNEFLLHYQPQINLTNGAIIGVEALVRWRQPEQGIIPPDEFIPLAEETGLIVQLGKWVLREACRQARAWHDAGLPKIGISVNLSAR
QFREPGLKQTILDMLAETGLEARFLEMEITESMVMFDPEGAIAVLDELQQQGITFAMDDFGTGYSSLNYLKRFPIHKLKIDQSFVRNITTDSNDAAITNA
VIELAHGLKLKVIAEGVETEEQRSFLRAHQCDEMQGYLFSRPVPAEDIVNLLIAN-----
>tr|A0A023X1S9|A0A023X1S9_9ACTN PAS domain S-box protein OS=Rubrobacter radiotolerans GN=RradSPS_0721 PE=4 SV=1
--------------------------------------------------------------VTE---REEALEALRISRERGEAILRAVPDVACRITLD
GVYLDVR-AGEKRPLLRLEQVLGNN---VRNVLGEETGGALLAKVREAVRTGGVESLEYP-LQTEDGEKMIEARVVYVGG-----DEAIYFARDITERYR
MVFRLNQSEAIVESIPDLVFRFDREGRYLDLAPGTEAGVCAPEQEVVGRTVRETMPEEVAERFLAAI-GSALDTGEVQSEFELDVGGGEKSWEGRF--VA
CRTEGTTEEVICLVRDIDERREFESRIRYLAYHDELTGLPNRTGFMERFETAMAD--PLRNPRAVLLIDLEDFAKINSSLGREAGDRLISLFAAQAESYL
GVRSEFARFGGSEFAAFLEDVELEVAGIISGAVSAYQDVPFRLDEIDVFLKVRIGVALVEAEDRV-ADAMRKVSVALREAKRDRQSVWRVYSEPMGLRAV
SDIRLERDLRRAIENRELDVFYQPEVFLKSGRLYSFEALARWDHPTRGRIGPVDFIPLAEETGLIIPLGEYVLSEACRQMEIWNRPGLGDCTVSVNVSAL
QLRQRNFADRVLEALERNGLGPGQLQIEITESAAAADLEASMRTFSQLRELGVRIALDDFGTGYSSLSHLRKFPLDAVKLDRSFVSEVTEESKMYRVVAS
VIRLAHALDLEVIAEGVETEEQISTLRELGCDIGQGYWFARPMSGPKTLEVIGS------
>tr|K2KRP0|K2KRP0_9PROT PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Thalassospira profundimaris WP0211 GN=TH2_09729 PE=4 SV=1
--------------------------------------------------------------ITK---NRQAEYDLRRRQERYRALVQTAGSVILFLDAE
GRILEYNRECEWTFGYSME-AAGQN---FFDLLVEEDR------ARRRLLSEIIKDEVSF-KRRDGETRLLQWNARAHFGEDGDVAGVICIGQDVTEKLS
VERALRHAEGIFENSAEGLFQSIPLGPILSANPAFASILGYDAVESLIAKEHDYLNPVNRLRFI----GRLLRDGIVQGETEMRREDGKIIWVEENARLV
RDEKGRPTLIDGSITDITDRKRSEARIQFLAHHDGLTGLPNRTLFQERLAAAVARSKRERCHFVLMMFDLDNFKDINDTLGHPIGDLLLQGVGERMRVCL
RNEDVVARLGGDEFAVLIHEPGSEEVTFVAQRLIERISERFMLDGNEVQASTSVGICMYPQDGRDEKDLLRNADLALYCSKAEGRNRYHFFEPKLQVEVQ
ERKAMERDLSHAIENDELELFYQPIIDIVGHRIIGMEALVRWFSPSRGQVSPVDFIPVAERMGIIADIGKWVLKRACEQTKAWRDAGYGQLTISVNLSPL
ELRHEDLIESVGEVLSRTQLDPHQLQFEVTEGAVMDNPREAAITLGILRNQGIRIAIDDFGTGYSSLAYLKRFPVDKIKIDRSFIIDIDSSDGNAAIVRA
VVFLARSFGMAVNVEGIETEIQLEHIASEGVDEVQGFYFSKPISASDMESLLKA------
>tr|A0A074J793|A0A074J793_9PROT Diguanylate cyclase OS=Thalassospira permensis NBRC 106175 GN=SMB34_07260 PE=4 SV=1
--------------------------------------------------------------ITK---SRQAEYDLRRRQERYRALVQTAGSVILFLDSE
GRILEYNRECEWTFGFSME-AAGQN---FFDLLLDGER------DQKRLISEIIKDEVSF-RRRDGEVRLLQWNARAHFGEDGDVSGVICIGQDVTEKLS
VERALRRAEGIFENSAEGLYQSRPLGDILSANPAFVSILGYDSADELLVSQAGYLNPTNRLRLT----GKLMRDGVVQGEAEMRRRDGKIIWVEENARLV
RDDKGVPVLIEGSITDITDRKRSEARIQFLAHHDGLTGLPNRTLFQERLAAAVKRGKHEKRSFVLMLFDLDNFKDINDTLGHPIGDLLLQGVGERMRVCL
RNEDVVARLGGDEFAVLIHDPGTEEVTLVAQRLIERVSERFMLDGNEVQASTSVGICMFPQDGRDEKDLFRNVDLALYCSKAEGRNRYHFFEPRLQVEVQ
ERKALERDLSHAIENDELELFYQPIIDIANHKIIGMEALVRWFHPSRGQVSPVDFIPVAERMGIIADVGHWVLNQACKQTRRWLDAGYGELTISVNLSPL
ELRHEDLIESVGDVLERSRLNPTQLQFEVTESAVMDNPREAAITLGILRNQGIRIAIDDFGTGYSSLAYLKRFPVDKIKIDRSFIIDLDSRDGNAAIVRA
VVFLARSFGMAVNVEGIETEMQLERIVSEGVDEVQGFYFSKPIPASDFEMLLKS------
>tr|Q2J048|Q2J048_RHOP2 Diguanylate cyclase/phosphodiesterase OS=Rhodopseudomonas palustris (strain HaA2) GN=RPB_1452 PE=4 SV=1
--------------------------------------------------------------CTE---LRLLSKQLVTTKQFLESVIDNIPCVAAKNIED
GRYILANRAFEKLSGMPRDRIIGAT---AEEIYSPRTATAVQDVDRLALDAKKGFRTELT-VEFGRRELVLETDRVVAYNDRNEPEFIIALFEDITDRQV
LARELDKTRLVVDNIPVGLTQSTSSGRYLLANRGAEIILNRRREDAIGLTCGDIFNPK-EARLIRERD---------GDEHPISTRNGLRLFVTRRI-TV
ADEAGAESYLIKTHVDVTDRRQTEARMAHMAYHDGLTDLPNRTSFLKSLSQMIEACDAAVDEFAVLSVDLDGLSEINDVFGHAIGDQLLIEVASRIEQ-A
SQGGVVARLGGDEFGLLIDGPQPAA-RRLAERVSKALARDFEIDGKTVRTGATTGIALFPRDGRDAASLLANASAALFRAKAHARGSIGLFAPEMDMQIR
DRRALHQDLSNAIRNGELSLYYQPQAAIGEGDIVGFEALARWRHPTRGFVPPGEFIPLAEESGLIVEIGEWILREACREAASWPK----PLQIAVNLSPA
QFLNTDLVATVHQVLVETGLQPGRLELEITEGVLIDDFDRGLALLRRLKTLGVRVSMDDFGSGYSSLTYLQAFPFDKIKIDRAFIMHLGRNVQSAAIVRA
VIGLGHGLGVSLVAEGVETQEQLDFLVDEGCDAVQGYLIGMPAPIDQYPVLVGL------
>tr|Q13B73|Q13B73_RHOPS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodopseudomonas palustris (strain BisB5) GN=RPD_1429 PE=4 SV=1
--------------------------------------------------------------CTQ---LRRVSKQLATTSQFLESVIDNIPCVAAKSIDD
GRYILANRAFEKLSRLPREQIIGKT---AEDLFPPRSAAVIRDSDRVTLESKNGFRSELS-IEFGQRDVVLATDRVVAFNERNEPEFIIVLFEDVTERQM
LARELDKTRLVVDNIPVAVTQNASNGAYLLANRGAEVILNRRREDAIGLTSGEIFNAK-EARLIEERD---------GGEYPISTKNGLRLFVTRRM-TV
ADEAGNTNYLIKTHADVTDRRQTEARMAHMAYHDGLTDLPNRTAFLKALAQMIEACDCTVDQFAVLSVDLDGLAEINDVFGHAVGDKLLIEVARRIER-A
SRGGVVARLSGDEFGLIIDGPQPAA-HALAERVAEALADGLEIDGKTVRTGVTTGIALFPRDGKDAASLLANAGAALFRAKARARGSVSLFAPEMDMQIR
DRRALHQDLSNAIRNGELTLHYQPQAAIDETDVVGFEALARWRHPTRGFVPPGEFIPLAEESGLIVEIGEWILREACREAASWPK----PLQIAVNLSPA
QFLNSDLVGFIHQVLLETGLQPGRLELEITEGVLIEDFERGLALLRRVKALGVRVSMDDFGSGYSSLTYLQAFPFDKIKIDRAFIMNLGRNAQSASIVRA
VIGLGHGLGVSLVAEGVETQEQLDFLVDEGCDAVQGYLIGRPAPIDQFPCMVGL------
>tr|B3QKP0|B3QKP0_RHOPT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodopseudomonas palustris (strain TIE-1) GN=Rpal_4646 PE=4 SV=
--------------------------------------------------------------CSE---LRRMSKELSTTKQFLESVIDNIPCVAAKSIED
GRYILANRAFETLSGLSRDKIIGAT---ADQLYPARSAASIREADQSALQSTGAFQSELT-VELGRGDRILASNRVVARNEHGEPEFLIALFEDVTNRRA
LSVELEKTKLVIDNIPVALTQNTADGRYMLANRGAEIILNRRREDATGLTTGEIFNAK-EARLIAERD---------GGEHPISTAGGLRLFVTRRM-TV
TDEADQAHYLIKTHVDVTDRRQTEARMAHMAYHDGLTDLPNRDAFLKSLTQMIEACDNAVDEFAVLSVDLDGLKEINDVFGHAIGDKLLIEVARRIEW-A
SRGGVVARLSGDEFGLIIDGPQPAA-RDLASMVAKALAPGFVIDGKTVRIGVTTGVALFPANGTDAASLLANAGAALFRAKAKARGSVTVFEPEMDMQIR
DRRVLHQDLSNAIRNGEMSLYYQPQASVGNNDIVGFEALTRWRHPTRGFVPPSEFIPLAEESGLIVELGEWILREACRQAASWAR----PLQVAVNLSPA
QFLNTDLVAFVHEVLLQTGLEPGRLELEITEGVLIEDFDRGLSLLRRLKALGVRVSMDDFGSGYSSLTYLQAFPFDKIKIDRAFIMNLGRNPQSAAIVRA
VIGLGHGLGVTLVAEGVETQDQLDFLVDESCDAVQGYLIGKPAPIDQYRWLVGL------
>tr|A0A0D7EW89|A0A0D7EW89_RHOPL Diguanylate cyclase OS=Rhodopseudomonas palustris GN=OO17_08460 PE=4 SV=1
--------------------------------------------------------------CTE---QRRLSHEVATTKQFLESVVDNIPCIAAKSLED
GRYILANRAFEDLVRLSRGQIVGKR---ADEIFSPNAAKSIKEADQAALAAERRLRIEFP-LERDDKMRLLESNRVIARNDKNQPEFLITLLEDVTDRRS
MSAEFERAKLVVDNVPVSLTQDVTDGRYLLANRSAEIILNRRREDAIGLNCADIFNAK-EARLISDRD---------RKEHPISTKDGLRLFLTRRM-TV
LDGAGAPQYLIKTHEDVTDRRQTESRMAHMAYHDGLTDLPNRLAFMQALAQMIEACKSVNEEFAVLSVDLDGLKEINDVFDHAIGDRLLIEVSRRIET-A
SRGGVVARLSGDEFGLIIDGPQPSA-RELAERVAAALATGFTIDGKSVRIGVTTGISVFPGNGTDAASLLANAGAALFRAKVKSRGSVQLFEPEMDQQIR
DRRALHQDLSNAIRNGELSLHYQPQASFDRTDIIGFEALARWHHPERGMVPPAEFIPLAEESGLIVEMGEWILREACREAASWSR----PLQVAVNLSPA
QFVKTDLVAFVHRVLLETGLKPSRLELEITEGVLIDDFDRGLALLRRLTALGVRVSMDDFGSGYSSLTYLQAFPFNKIKIDRAFIMNLGRNPQSAAIVRA
VINLGHGLGVSIVAEGVETRAQLDFLVAEHCDAVQGYFIGRPGPIEQYAALVGP------
>tr|Q20ZF5|Q20ZF5_RHOPB Diguanylate cyclase/phosphodiesterase OS=Rhodopseudomonas palustris (strain BisB18) GN=RPC_3955 PE=4 SV=1
--------------------------------------------------------------CTP---QRELSRQLATAKQFLESVIDNIPCVAAKAIED
GRYILANRAFERFCGLPRDRILGRR---TAELFSAATAATIGEADRMAIDSHDPLRGELT-VDVGGGDRVIDNNCVVACDDKNRPEFLIALFEDITERRS
LSQELVNTKLVVDNIPISLTQSTQDGRYLFANRGAEAILNRCREDAVGLSALDIFNPK-EAKLIAERD---------RDEHPISTKDGLRLFLTRRV-TV
VDGEGAPQYLIKTHEDITDRRQTEAQMAHMAYHDGLTDLPNRLAFLQALAQMIEACRDTTEEFAVLSVDLDGLKEINDVFGHAVGDKLLVEVARCIQL-S
SRGGVVSRLSGDEFGLIIDGPQPAA-MHLAAEVAKAVAGGFLIDGKQVRIGVTTGVAVFPANGADAASLLANAGAALFRAKARMRGSVSLYEPEMDRQIR
DRRILHQDLSAAIKNGEMSLHYQPQANIGGDDFVGFEALARWFHPTRGFVPPSDFIPLAEESGLIVEMGEWILREACREAASWSK----PLQIAVNLSPA
QFLNSDLVSAVHTILLETGLKPSRLELEITEGVLIEDFDRGLSLLRRLTALGVRISMDDFGSGYSSLTYLQAFPFDKIKIDRAFVMNLGHNPQSAAIVRA
VIGLGHGLGVSIVAEGVETQQQLDFLVAEGCDAVQGYFIGKPAPIEQYSRLVGL------
>tr|Q07J74|Q07J74_RHOP5 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodopseudomonas palustris (strain BisA53) GN=RPE_4084 PE=4 SV=
--------------------------------------------------------------CTG---QRELSRQLATTKQFLESVIDNIPCVAAKAIED
GRYILANRAFERFAGMSREQMLGKR---PDEIFPEPTAAAVTNADKAAIESHAPLHVELN-VLVSSGTRVIESNRVVACNDKNEPEFLIALFDDITEKRE
LSRELVNAKRVIDNVPICLTQSAVDGRYLLANRSAETILNRLREDAIGRTVAEIFDPQ-EGKLIAERD---------GQEQPISTKDGLRMFVTRRQ-TV
LDEFGEPQYLIKTHEDVTDQRQTEARMAHMAYHDGLTELPNRAAFLQALTQMIEACCDTADEFAVLSVDLDGLKEINDVFGHAVGDKLLIEVAERIKT-A
SRGGVVSRLSGDEFGLIIDGPQPSA-LDLADEVARAVGEGFQIDGKAMRIGVTTGIATFPNNGQDAASLLANAGAALFRAKAKMRGSVSIYEPEMDQQIR
DRRVLHQDLSKAIKNGEISLYYQPQARTGHDDITGFEALARWRHPTRGFVPPSDFIPLAEESGLIVELGEWILREACREAASWAK----PLQVAVNLSPA
QFLNSDLVSAVHRILLETGLKPSRLELEITEGVLIEDFDRGLSLLRRLTSLGVKISMDDFGSGYSSLTYLQAFPFDKIKIDRAFVMNLGHNPQSAAIVRA
VIGLGHGLGVSIVAEGVETQQQLDFLVQEGCDAVQGYFIGRPHPIEHYARLVGA------
>tr|U1GXP4|U1GXP4_9BRAD Diguanylate cyclase (GGDEF) domain-containing protein OS=Bradyrhizobium sp. DFCI-1 GN=C207_04409 PE=4 SV=1
--------------------------------------------------------------CTD---QRKLSRKLASTTQFLESVLDNVPCVAAKNIED
GRYIFANRAFERFSRFSRDHIVGKR---ADEIFRPETAVSIDTADRAALNAEGYHRSEFS-VERGAEKRILASNRVIARNEAGEPEFLIALFEDVTDRRS
LSRELENNKLVVDNIPVSLIQRVSDGRYLLANRSAETILNRRREDAAGLTASDIFNAR-EAKLIVARD---------RSEHPISTKDGLRLFLTRRM-TV
LDDSGEPQYLIKTHEDVTDRRQTESRMAHMAYHDGLTDLPNRSAFLQALTQMIEACDGTDEEFAVLCVDLDGLKEINDVYGHAMGDKVLIEVAQRLQA-V
ARGGVVARLSGDEFGLIIDGRQPAG-IALAEQAGEALGQDFLIDGKSVRTGLTTGIAVFPHNGSDAASLLANSGAALFRAKAKSRGTISIFEPEMDQQIR
DRRVLHQELSVAIKNGELSLYYQPQAVVAGSQIIGFEALARWHHPVRGFVPPSDFIPLAEESGLIVEMGEWILREACREAASWTV----PMQVAVNLSPA
QFTHGDLVGLVHSILLETGLTPDRLELEITEGVLIEDFDRGLSLLRRLKALGVRISMDDFGSGYSSLSYLQAFPFDKIKIDRAFVINLGRNPQSAAIVRA
VIDLGHGLEMSIVAEGVETEAQLAFLAEEGCDAVQGYLIGRPAPIGQFAALVGG------
>tr|H0T1R7|H0T1R7_9BRAD Putative diguanylate cyclase (GGDEF)/phosphodiesterase (EAL) with PAS domains OS=Bradyrhizobium sp. STM 3809 GN=BRAS3809_337006
--------------------------------------------------------------CTV---QCRLERELASTKQFLESVIDQVPCVAAKNIED
GRYIFANRAFEQFSQMSREQIIGRR---PGELFGDETAANIAAADRAALLAGTTHRSELV-VRRGDDKRILESHRVVARNDKNEPQFLIALFDDATERRS
LSLELEKTKLVVDNIPVSLIESARDGRYLLANRRAEIILNRKREDATGLTAADIFNPR-EARLIVARD---------RGEHPISTKDGLRLFLTRRV-TV
MGESDEPQYLIKTYEDVTDRRQTESRMAHMAYHDGLTDLPNRAAFLQALSQMIEACRDTGEEFAVLNVDLKALKDVNDVFGHAIGDKLLIEVARRVHA-V
ARGGVVARLSGDEFGLIIDGKQPAG-RALAEQLAEAIAVEFQIDGKSIRTALTTGISVFPHNGSDPASLLANAGAALFRAKAKARGSITFYEPEMDQQIR
DRRVLHQELSVAIKHGELSLYFQPQASVDSSEIIGFEALARWQHPVRGFVPPSDFIPLAEESGLIVEMGEWILREACREAASWPK----PLQVAVNLSPA
QFVHGDLVGLVHSILLETGLSPGRLELEITEGVLIEDFDRGVSLLRRLKALGVRVSMDDFGSGYSSLSYLQAFPFDKIKIDRAFVMNLGRNPQSAAIIRA
VIGLGHGMNMSIVAEGVETPEQLGFLAEQGCDSVQGYLLGKPLPIDKYDGIVGR------
>tr|A0A023XPV6|A0A023XPV6_BRAJP Uncharacterized protein OS=Bradyrhizobium japonicum SEMIA 5079 GN=BJS_01611 PE=4 SV=1
--------------------------------------------------------------VSD---QRKLSRQLASTKQFLETVLDHVPCVAAKNIED
GRYIFANSAYERFWGFSRDHAVGKN---ARELFAPISAASIEAADKAALKSDGQFRNEFE-VDRAGERRMVASIRIVVRDESNKPEFLMLVFEDITDRRS
LSQELESTKLVVDNIPVALIEQVKDGRYLLANRSAETILNRRREEATGLTASDIFNPK-EAKLIIARD---------RGEHPISTKDGLRLFLTRRA-TV
LSDAGEPQYLIKTHEDVTDRRQTESRMAHMAYHDGLTDLPNRAAFLQALTQMIEACEGTSEEFAVLCVDLDGLKEVNDVFGHALGDKLLIEVAQRLQD-S
ARGGVVARLSGDEFGLIIDGKQPAG-LALAQQIGEAVAQEFQIDGRAVRAGATTGMSIFPHNGADGAALLANAGAALFRAKQKSRGTISLYQPEMDQQIR
DRRVLHQDLSMAIKNGELALAFQPQGVVVESEIIGFEALARWQHPVRGQVSPAEFIPIAEESGLIVEMGEWILREACREAASWPK----PLQVAVNLSPA
QFMHGDVVGLVHSILIETGLAPGRLELEITEGVLIEDFDRGLALLRRLKALGVRISMDDFGSGYSSLSYLQAFPFDKIKIDRAFIINLGRNPQSAAIVRA
VIDLGHGLEMSIIAEGVETLDQLAFLAKEGCDGVQGYLLGKPLPIGKYAGLVGR------
>tr|Q1QNX8|Q1QNX8_NITHX Diguanylate cyclase/phosphodiesterase OS=Nitrobacter hamburgensis (strain X14 / DSM 10229) GN=Nham_1241 PE=4 SV=1
--------------------------------------------------------------CSE---QRKLARQLATTKQFLESVIDNVPCIAAKGIED
GRYILVNRAFERFSRVSRDFIVGRR---ADEIFQPQTAANIAATDQVALASDSHYYSEMV-FERGSEKRTLANNKVVARNEAGQPVFLIALFEDVTERKS
LSRELENAKTVVDNIPVSLIQCASDGHYLLANRRAETILNRRREDAIGLTASDIFGPR-DAKLIVARD---------GGEHPIRTSEGLRLFLTRRV-TV
RGDDGEPQYLIKTNEDVTDRRQTESRMAHMAYHDGLTDLPNRTAFLKALSQMIEACQGTDDEFAVLSLDLDGLKEINDVFGHAVGDSLLIEVARRIQS-A
AHGGLVARLSGDEFGVIIDGKQPVG-QALAQQIVAAMVPEFLIDDKSVRTGLTTGISLFPRDGTDPASLLANAGVALFRAKAKSRGSICVFEPEMDRQIR
DRRVLHRDLSNAMRNGELSLHYQPQARLVDDDVIGFEALTRWSHPTRGFVPPGDFIPLAEESGLIVAMGEWILREACREAASWPS----PKQIAVNLSPV
QFIHGDLVGLVHSILLETGLNPSRLELEITEGVLIEDFERSLALLRRLKALGVRIAMDDFGSGYSSLSYFQAFPFDKIKIDRGFVMYLGRNPQSAAIVRA
VIGLGHGLDVSIVAEGVETQEQLGFLADEGCDAVQGFFIGKPEPIAHYATLVGR------
>tr|H0TYY7|H0TYY7_9BRAD Putative diguanylate cyclase (GGDEF)/phosphodiesterase (EAL) with PAS domains OS=Bradyrhizobium sp. STM 3843 GN=BRAS3843_740085
--------------------------------------------------------------CTE---RRRLERELASTKQFLESVLDHVPCVAAKNIED
GRYIFANRAFERFSGISRERIKGRR---ASELFSPETAANIEAADRAALLAGEAYRSELM-IKRGEERRILASNRVIARNEKSEPQFLIALLDDDTERRA
LSYELENAKLVVDNIPVSLIERVSDGRYLLANRSAEIILNRKREDVTGLTTADIFNPR-EAKLIIARD---------RSEHPISTKDGLRLFLTRRM-TV
LGDNDEPQYLIKTYEDVTDRRQTESRMAHMAYHDGLTDLPNRAAFLQALSQMIEACAGTGEEFAVLNVDLKGLKEVNDVFGHAIGDKLLIEVAHRVHD-A
ARGGVVSRLSGDEFGLIIDGKQPAG-QKLAEQLAEAIAIEFQIDGKSIRTALTTGISVFPHNGSDPASLLANAGAALFRAKAKSRGSITFYEPEMDQQIR
DRRVLHQELSVAIKNGELSLYFQPQASVDASEIIGFEALARWKHPQRGFVPPSDFIPLAEESGLIVEMGEWILREACREAASWPK----PLQVAVNLSPA
QFVHGDLVGLVHSILIETGLAPDRLELEITEGVLIEDFDRGLGLLRRLKALGVRISMDDFGSGYSSLSYLQAFPFDKIKIDRAFVMNLGRTPQSAAIVRA
VIDLGHGMNMSIVAEGVETAEQLGFLAEEGCDSVQGYLLGKPLPIEKYDALVGR------
>tr|F7QFY3|F7QFY3_9BRAD Diguanylate cyclase/phosphodiesterase OS=Bradyrhizobiaceae bacterium SG-6C GN=CSIRO_0358 PE=4 SV=1
--------------------------------------------------------------CTD---RRRMQKKLATTTHFLESVIDNIPCVAVKNIED
GRYILANRAFEQFSGISRNKIIGHT---AEKVYIPEVAKAVSQADHDAIVSTSQTRTELL-IELHGEKRLVACNRMIARDEKGRPEFLVSLFEDVTERRS
LSREIQSAKTVVDNIPVSVVKRLSDGQYVLANRGAAATLNRPREDVIGRTIEDIYNPA-DAMFIRKRD---------QGEHPIQTANGLRLFLTRRV-TV
LDDAGQPQYLIKTNEDITDRRETESRMAHMAYHDALTELPNRAAFLQALEQMIDACEDTGEEFAVLSLDLDRLKEINDVFGHEVGDQLLIEFSRRLES-V
IAGGVVARLSGDEFGLIIDGMQPSA-RALAARLMQVMRTEFVFDGRSVRIGLTIGISVYPRNGRDAETLLTNADAALFRAKTTARGSINFFDMELDQQLR
DRRALHQDLSTAIRNGELSLHYQPQARMKTDHVLGFEALARWTHPVRGFVPPGDFIPLAEESGLIVEMGEWILRKACHEAASWPK----DLQIAVNLSPA
QFLHGDLVGLVHSILLETGLAPGRLELEITEGVLIDDFERGLSLLRRLKALGVRIAMDDFGSGYSSLTYLQAFPFDKIKIDRAFVMNLGRNPQSAAIIRA
MIGLGHGLNISIVAEGVETQEQLSFLADEACDQVQGYFLGKPAPIEAYSEWVGR------
>tr|Q89VU0|Q89VU0_BRADU Bll0955 protein OS=Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110) GN=bll0955 PE=4 SV=1
--------------------------------------------------------------VTE---RLKYEETLRQQNFILDAAMENMAGLAFYD-SD
MRLRVCNTTYRKIYWLSEETRPGTH---LGELIERSMANGAFVSEYLEAASKIANRDSSP-M----RRRMTNDTVISVRYCALAEGGFVATYEDITERER
AIEELSEQYAALNNMSQGL--------CMLDSSLRVIVCNRRYIEMYGLSPDVVKPGI-SMREIMDHSGAKLYADYVEREHTLHRSDG------RII-KL
NHKRMELGGWVVTYEDVTERHKAQARVAHMARHDSLTDLPNRTLFREKMGEGLNQVAIAGGAMAVLCFDLDNFKTVNDRLGHAAGDRLLRWVAARLKENV
GEHDTVARLGGDEFAVLQRGPQPSA-EKLARRLVEIIGHPPPLESQSIHVGVSVGIAIAPDHGLDADELMKCADLALYQAKARGRGAYQLFEPEMEEEAR
SRHALEHNLRGALEAREFHLVFQPQVRLESSELTGFEALLRWKHPSRGFVSPAEFIPIAEENGLIVPIGEWVLRTACATAASWPD-----VTVAVNLSPV
QFRARGLAAMVTSALAEAGLPPQRLELEVTETALLDDSEATIEILHQLRALGVRVSLDDFGVGYSSLSYLRKFPFDRIKIDRSFVGTLGESPESVAIVRT
IASLGSVLGVETTAEGVETEEQLDFVRECGCTAVQGYYFGRPCPAAEVARTIET------
>tr|K8RJR2|K8RJR2_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Burkholderia sp. SJ98 GN=BURK_019000 PE=4 SV=1
----------------------------------------------------------------------EANRKIFVARQVAHGLLAIAEDCLKLLSLE
GRIMCISEVGGQLIEADHADLIGVD--WL-ALWDGPDAR---RAFER-AKAGESTSFSGACRTMNGTLKWWTSTFAPVYGEHGRVSAVLCKSRDITAERN
LIDELRGNARVQKDMEDDAVFWTATRELLHVSSAFERMWEMPMSAL-EADQTAWSQSVHPEALRDEMRTAVNTGAATQSYFRLCLQHDRTRWVRADIYPV
IED-GAVSRVVSVCVDATDERERLQELHRLANTDSLTGLANRNAMMDALVK---R-CEALAPFAYLFIDIDRFKSINDTAGHIAGDAVLRTIARRIAETL
PDGAVAARPGGDEFTVILPGSFDESIERACRKLSLACHRPIEIDCKSVTMTCSIGVALYPEHGRTPEALFISADMAMYAAKRAGRNTFRVFGDREK-DDL
ARAHLEAQLHGAIREKEFVLHYQPQYRVDSGALVGVEALLRWNHPQLGLLGPGAFVPVLEESALIVEAGHWVIREAVQAGSQLALALPQACSVALNVSPK
QFRDPRLVSVLRHAIRRAGIDSNRITLEITESALIDNVDDAQVVLSNVRAMGVRIAIDDFGTGYSSLSYLARFRPDVLKLDKSFVDNIATDAMVRTVVEG
VIDLAHKLGVTVVAEGVETQEQLDTLRDVRCDKVQGFLLSRPVLLASLMMRTDAE-----
>tr|R4X464|R4X464_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Burkholderia sp. RPE64 GN=BRPE64_DCDS10350 PE=4 SV=1
----------------------------------------------------------------------DAHRKTFVARQVAYGLLAIAEDCLKLLSLD
GRIMCISEVGRRLIEAECADLVGID--WL-ALWDGPDAR---QAFER-ARAGQSTSFSGACRTMTGNLKWWTSTFAPVYGEHGKITAVLCKSRDITAERN
LIDELRGNARVQKDMEDDAVFWTASQELLHVSSAFERMWEMPMSVL-DADQTAWSQRVHPDALRDEMRTAVKTGAATQSYFRLCLPHERTRWVRADIYPV
TED-GAVSRVVSVCVDATDERQRLQELHRLANTDSLTGLANRNAMMDALVA---R-CEAGAPFAYLFVDIDRFKSINDTAGHIAGDAVLRAIARRIQDAL
PEGAVAARPGGDEFTVILPGAFDESIARACRMFALACHRPIKVDCKSLTMTCSIGVALHPDHGRTPEALFISADMAMYAAKRAGRNTFRVFGEREK-DDL
ARAHLESELHGAIRENQFVLHYQPQYRVDSGALVGAEALLRWNHPTLGLLAPGAFVPVLEESALIVEAGHWVIREAVQAAGRLAGAMPSVCSVALNVSPK
QFRDPRLVSVLRHALKRACIESDRITLEITESALIENVDAAQEVLSNVRAMGVRIAIDDFGTGYSSLSYLARFRPDVLKLDKSFVDNIATDVMVRTVVEG
VIDLAHKLGVIVVAEGVETQEQLDTLRDVHCDKMQGFLLSRPVPLASLMETAGVK-----
>tr|G8MNS8|G8MNS8_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. YI23 GN=BYI23_D009570 PE=4 SV=1
----------------------------------------------------------------------VAKRDVFVARQVAHGLLSIAEDCLKLISLE
GRIMCISEVGRRLIEADCADLVGVD--WL-ALWDGPDAR---HAFER-AKAGESTSFSGACRTLNGKLKWWTSNFAPVYGEHGQVTAVLCKSRDITAEVK
LIDELRGNARVQKDMEDDAVFWTATRELLHVSSAFERMWEMPVSAL-EADQTAWSQRVHADALRDEMRTAVNTGAARQSYFRLCLPHDRTRWVRADIYPV
TED-GAVSRVVSVCVDATDERQRLQELHRLANTDSLTGLSNRNAMMDALVK---R-CESETPFAYLFVDIDRFKSINDTAGHIAGDAVLRTIARRIQETL
PDGAVAARPGGDEFTVILPGAFEESIARACRRLSLACHRPIAIDCKSLTMTCSIGVALYPEHGRTPEALFIGADMAMYAAKRAGRNTFRVFGDREK-DDL
ARAHLEAELHGAIRENQFVLHYQPQYVVESGALVGVEALLRWDHPQLGLLAPGAFVPVLEESTLIVEAGHWVIREAVLAAARLTLALPEVRSVAVNVSPK
QFRDPRLVSVLKAAIKRGSIASHRITLEITESALIDNVDDAQEVLSNVRAMGVRIAIDDFGTGYSSLSYLARFRPDVLKLDKTFVDNIATDTMARTVVEG
VIDLAHKLGVTVVAEGVETREQLDALRAVRCDKVQGFLLSRPVPLDRLMTQAEEQ-----
>tr|A0A069P835|A0A069P835_9BURK Diguanylate cyclase OS=Burkholderia grimmiae GN=BG57_10590 PE=4 SV=1
----------------------------------------------------------------------QWRRQIFVARQLSNGLLFIAEDCLKLLDLE
GCVVCISDVGRKLIGADCADVVGVD--WI-ALWNGPDAR---DAFER-AKAGASTSFSGSCRTMTGALKWWTSSFAPVCGEAGRVVSVLCKSRDITAEVA
LIEELRGNARVQKDMEDDAVFWTTTRELLHVSSAFERMWEMPVAAL-ETDKTAWMQRVHADSLRDKMREAVNTGAPSQSYFRLCLSGERTRWVRADIYPV
NED-GAVSRVVSVCVDATEERMRLQELHRLANTDSLTGLRNRNAMTDALVD---R-CASGEPFAYLFIDIDRFKSINDTAGHDAGDAVLKAIARRIADAM
PEGAVAARPGGDEFTVILPGRFDQRIERACRRLALACHRPIKLGCRTVTMTCSTGVALYPDHGGTPEDLFISADMAMYAAKRAGRNAFRVFGESEK-GDL
ARAHLESELHDAIRANQFLLHYQPQYRVDTGALAGVEALLRWNHPQLGLIEPGEFVPVLEESGLIVEAGHWIIREAVQAAARLAAAAPDVRSVAVNVSPK
QFRDPRLVSVLMHAMKRSGVDADRITLEITESALIDNVDDAQDVLARIREMGVRIAIDDFGTGYSSLSYLARFRPDVLKLDKSFVDNIATDPMMRTVVEG
VIGLAHKLGVTVVAEGVETPEQLEHLKDARCDKMQGFLRARPVALDALLEDVAYA-----
>tr|A0A0C1YJX4|A0A0C1YJX4_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. MR1 GN=BurMR1_5006 PE=4 SV=1
----------------------------------------------------------------------QWRRQIFAAQQLSNGLLSIAEDCLKLLDLD
GRVVCISDVGRKLIDASCARIVGMD--WI-ATWDVPDAR---NAFER-AKAGESTSFSGAYRTMTGSLKWWTSSFAPVYGEAGRVVSVLCKSRDITAEVA
LIEELRGNARVQKDMEDDAVFWTTTGELLHVSSAFERMWEMPVAAL-EADKTAWMQRVHADSLRSKMREAVNTGAPSQSYFRLCLPDERTRWVRADIYPV
NED-GAVSRVVSVCVDATDERMRLQELHRLANIDNLTGLRNRNAMTDALVE---R-CASGEPFAYLFIDIDRFKSINDTAGHSAGDAVLKAIAARIAEAI
PEGAVAGRPGGDEFTVILPGRFDERIERACRRLAVACHRPIKVGCRTVTMTCSTGVALYPDHGRTPEDLFISADMAMYAAKRAGRNAFRVFGESEK-GDL
ARAHLESELHDAIRGNRFLLHYQPQYCVETGALAGVEALLRWDHPQLGLIAPGEFVPVLEESGLIVEAGHWIIREAVQAAGRLAVAAPGVRSVAVNVSPK
QFRDPRLVSVLLHAMKRCGIDSGCITLEITESALIENIDDAQEVLARIRAMGVRIAIDDFGTGYSSLSYLARFRPDVLKLDKSFVDNIATDAMMRTVVEG
VIDLAHKLGVTVVAEGVETREQLEHLRQAGCDKMQGFLRARPVALDTLMEQIGCA-----
>tr|B5WB58|B5WB58_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. H160 GN=BH160DRAFT_0308 PE=4 SV=1
----------------------------------------------------------------------ADHARQSAATALASGLLHANRDCLKMLATD
GKMLRVSEHGAMLMEAESPELSGVD--WL-AFWTGDDRE---TALAG-ALSGASTSFTGSCATTKGRTKWWNSTLTPVTGEDGAVSALLCASEDVTQQCE
LLKTLRERNQLMQEMESGLVFYSYSERFHHVSAGVESVFGLTPQEL-SRKPSAWLDLVVPEPVLAEMNRVASEGTEGRVEYRIRRSDGCLRWIRSTAYPV
RDGCAKVTRIVGVGEDITLEQERLAALDRLAYTDGLTGLASRGALVRRMKS---L-CRQNVAFGLMFVDLDRFKVLNDTLGHTAADRLLKDIAKVIQGAL
PPDACVARLGGDEFAVIVE--NDATLATMAQSLLNRFSNDVRKDHAAPFVTASIGISIFPEHGRDHEALLTSADIAMYAAKRGGRNAFRFADKASS-ALL
GDFELERDLPTALASNQFVLHFQGIHEPASLAVKGVEALVRWNHPARGLVAPGSFIPILEESGFIVEVGTWIIDAALAQLAIWQTAGGKKLSMSVNVSAR
QLRDDSLVAIVNEALRKHQVSPGRLEIELTESALMENSSLAQATLMALKRLGVRIAIDDFGTGYSSLRYLADFSPDIVKIDRSFTARLGRDAAATSIVRG
IIQMSHELGIKVTAEGVETNQQLHALREAGCDYVQGFFLTMPTDAEKLVHCEGSV-----
>tr|D5WIF6|D5WIF6_BURSC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. (strain CCGE1002) GN=BC1002_4262 PE=4 SV=1
----------------------------------------------------------------------LDYARQSAATALASGLLHANRDCLKVLATD
GKMLRVSEHGAMLMEAESPELSGAD--WL-AFWTGADRE---QALAG-AVSGNSTSFTGSCATTRGRTKWWNSTLTPVTGDDGEVTALLCASEDVTQQSE
LLKTLRERDELMHEMELRLVFYSYSEHCHHVSAGVESVFGITPQEL-SNRPSAWLDLVVEEPLLAEMNRIASEVSEGRFEYRIRRPDGCLRWIRSTAYPV
CDGSANVVRIVGVSEDITLEQERLAALDHLAYTDGLTGLANRGALIRHMKK---L-CRQNVAFGLMFVDLDRFKVLNDTLGHTAADRLLQDIAKVIQGAL
PPDACVARLGGDEFAVIVRGESDATLASLAQSLLNLFSSDVRKDHAAPFVTASIGISIFPEHGRDHEALLTSADIAMYAAKKGGRNGFRFADEASS-DVL
GDFELECNLPTALASNQFVLHFQGIHEPASLAVKGVEALVRWNHPARGLVGPGSFIPILEESGFIVEVGAWVVDAALAQLAVWQAAGKKELSMSVNVSAR
QLRDDSLVAIVDQALRKHRVPPRCLQIELTESALMENPSLAQATLMALKRLGVRIAIDDFGTGYSSLRYLADFSPDIVKIDRSFTARLGRDSAAASIVRG
IIQMSHELGIKVTAEGVETNQQLHALRDAGCDFVQGFFLTKPMKAENLFQCECSV-----
>tr|B2JQ51|B2JQ51_BURP8 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia phymatum (strain DSM 17167 / STM815) GN=Bphy_4272 
----------------------------------------------------------------------AQQARHAAAMALASSFLDASRDCVKLLDLQ
GQMLRINDYGATLMEASSPVLAGAD--WL-GFWKGGDRT---TAFRN-ALNGTPASFRGTCTTTAGQPKWWDSQLIPVKDHGGKVVAVVCASLDITNQTQ
LLQQLRAKSELMSEMEAQLVFFSYSEYFHYITAGSSNVFGLEPEEF-MRNPNSWRELVVPEALQAEMTRIMTESTEGRAQYRIRKADGSVRWVRSTGYPV
IGDNGDVLRIVGITEDVTAEQERIAELDRLAYTDSLTGLANRAALLREIES---R-CAASKPFGLMFVDLDRFKVLNDTLGHLAADHLLRHVGGIIRRSL
PDDAYIARLGGDEFAVLIGSVVDPGLEAQAKALLGGLSENRLEGLAGAFITASIGISIYPEHGSGHDALLSSADVAMYAAKKTGRNGYQFAGKEAA-RTI
GDFELERDVPEALATNQFFLHFQTIHEPHSLAVHGAEALIRWQHPRRGRISPGDFIPLLEETGFVEDVGVWVLDNALRQLAAWRQAGAMNLGVSVNVSAR
QLGSEQIVQQVDRALKRHGIPPGKLEIELTETALMKNPKQARTSIVELKRLGARIAIDDFGTGYSSLMYLADFEPHTLKIDRHFTSKIEHDPTTQTIVEG
IIDLAHKLGIQVIAEGVEQTAQLDILRRVNCDYVQGYLLSRPQAPEGLMTRAQPG-----
>tr|K8RJ81|K8RJ81_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Burkholderia sp. SJ98 GN=BURK_010006 PE=4 SV=1
----------------------------------------------------------------------RSAARANATTALAKALLDANRECLKLLDAD
GRMVRISEYGAELMEASAPELAGSN--WL-GFWSGEDAH---DAFHA-AMSGARATFRGSCPTTSGAPKTWHSRLIPIENGDGGVEGVICASQDMTQQAE
LAAALCARETLMSEMEAGLCFYSYNTGFHHISAGCAAVFGLDAQTF-RESPQAWMALVLQEQLTAAMRRIAESKVSQKALYRIRRLDGNVRWIQSTGSPV
LDSAGNVARIVGISEDVTAEQDRLAELDRLAFTDSLTGLANRAALMCRIDE---R-CRKQAPFALMFIDLDRFKVLNDTLGHTAADRLLKSLSRVIRAAL
PADAFLARLGGDEFAVLIDGAKHDPLAEIARATLDALVQADQAHRA-GTITASIGISVFPENGGNRETLLTSADIAMYAAKKAGRNGYRFADKDSS-ERI
VDFELERDLPAALAKKEFQLHYQAIHEPHTREVRSVEALIRWRHPERGLVSPGVFIPILEESGFIAEVGAWVMDDALRQLALWRQAGARALGVSVNVSAR
QLRDATIVDVVDEALRRHALPASTLQLELTESALMDDPSLAQRTLGALKKLGVRIAIDDFGTGYSSLRYLADFAPDCVKIDRSFITRMESDQATRSIVCG
IIQMCHTLGLSVTAEGVEETAQLELLRHAQCDFVQGFLLSRPVAPDDVLGLPIAT-----
>tr|A0A0C1ZJI0|A0A0C1ZJI0_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. MR1 GN=BurMR1_2165 PE=4 SV=1
----------------------------------------------------------------------RELARANATAALARALLDANRECLKLIGPD
GRMLRISEHGAEIMQASSPELAGAN--WL-GFWSGDDAR---TAFDA-AMSGSRASFVGACPTTAGVPKTWQSRLIPIDDGRGGVRDILCASLDVTQEAE
LAADLRAKELLMSEMEAGLCFYSYSSYFHHVSAGCASVFGIEAKVL-RERPQAWVELVLPDELLATMQRITQSKDGGRARYRIEHPVNGVRWIQSTGYPI
LDANGNVVRVVGISEDVTVEHERLAELDRLAFSDSLTGLANRGALVLKIEE---R-CQRNAAFALMFIDLDRFKVLNDTLGHTAADRLLKSLSELIQAAL
PPDALLARLGGDEFAVLIDDAADTRLARIAKDILAALARSGEPSRADAFVTASIGISVFPENGADHETLLTSADIAMYAAKKAGRNGFSFADANST-ERI
VDFKLERDLPAALANRQFLLHYQAIHEPRTLEVRSVEALIRWKHPTRGLVSPGVFIPILEESGFINEIGAWVMDEALRQLALWRHAGARSLGVSVNVSSR
QLRDEAIVEVVNDALHRYELPASSLEVELTESALMENPARAQRTLSALKALGVRIAIDDFGTGYSSLRYLADFSPDTLKIDRSFVARLQDDRATQSIVGG
IIQMARALGVSVTAEGVEQTVQLEFLRDAACDRVQGFLLSQPVAPEKVLGLSIAA-----
>tr|A0A069NYD7|A0A069NYD7_9BURK Diguanylate cyclase OS=Burkholderia grimmiae GN=BG57_07625 PE=4 SV=1
----------------------------------------------------------------------RQHARANATSALAKALLDANRECLKLLDTD
GRMLRISEYGAELMQASGPELAGAN--WL-GFWSGDEAR---NAFDA-AIKGSRSAFVASCPTTAGVPKKWQSRLIPIDDGHGGVHAILCASLDITHEAE
LAADLRAKELLMSEMEAGLCFYSYSTYFHHVSAGCASVFGIDARTM-RERPQAWIDLVLPEQLYDAMQRITRLKTGGRARYRIQHPRRGVRWIQSTGNPV
FDARGDLVRIVGISEDITVEQERLAELDRLAFSDSLTGLANRGALVLKIEE---R-CRRNAAFALMFIDLDRFKVLNDTLGHTAADRLLKSLSERIQAAL
PHDAVLARLGGDEFAVLIDHASDQRLAGIAKDILAALARSGDPSRADAFVTASIGISVFPENGADQETLLTSADIAMYAAKKAGRNGFSFADKAST-ERI
VDFKLERDLPAALANRQFLLHYQAIHEPRTLEVRSVEALIRWRHPTRGLVSPGVFIPILEETGFINEIGAWVMDEALRQLALWRRAGARSLGVSVNVSSR
QLRDAAIVEVVNDALSRYELPASSLQVELTESALMENPALAQRTLSALKALGVRIAIDDFGTGYSSLRYLADFSPDTLKIDRSFVARLQDDRATQGIVSG
IIQMARTLGVSVTAEGVEQTAQLELLRESACDLVQGFLLSRPVAPDEVLGLSIKA-----
>tr|E8RCT2|E8RCT2_DESPD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfobulbus propionicus (strain ATCC 33891 / DSM 2032 / 1pr3)
--------------------------------------------------------------------------KQDKRLERYRSLFNNSLEGIFLTTPD
GRYLDVNPTLARIYGFSTPHLINHK--HQ-LYVTPNRR-----VLTL-ARDNKVIGFESQVRKRNGEVIWISENARAVYDERGNISYYEGTVMDITARKE
AELELEVQRAYFSQLFSAIVIIDTQ---VNCNHGFEDIIGFGM-----------RALIVPEVECEKLRNAILDGETVQCETQRRHRNGTLIPVDMIGFPI
RVG-QSINGIIYIYQDISERKSFEDQITHQAFHDALTGLPNRTLFGERLQRALSR-RRPELYYAVLMIDLNKFKAINDSLGHPAGDQLLIEVAKRLSVCV
RSVDTVARLGGDEFAIILEEFTAKELLKAARRMHSILCEPFSLYGNDITPGASIGIVPKIADYTSAEEILRDADIAMYRAKQQGKGIVL-FDKRMHQELV
ESISLEAELREVLAHDGLILHYQPIVSVLDECLQGFEALVRWNHPLRGMVPPDRFIPLAEENGLIVDLGKWVIAEACRALKSWQQSGTAGLTMSVNVSCR
QLTKPGLVEHVTEVLEHNQLNPRCLKIEVTESVLMHDVDRAINELNRLRALGVQIAIDDFGTGYSSLAYLRRMPIDHLKIDRSFISGVEEGIKNDQIVRS
IISLARSLGLGVVAEGVESREQLEWLRQLNCDRAQGFMFSRPVDNAKAQELIRKF-----
>tr|H8YWW0|H8YWW0_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiorhodovibrio sp. 970 GN=Thi970DRAFT_00576 PE=4 SV=
----------------------------------------------------------------------RQAALLADSEANYRSLFEGAQDPILVMDLA
EKILDANHRGIDLFGCSFDQ----A--PL-TWLIPADPK---PVWKQ-ALKGQAQRIETQIRTSRGHNIWTEINIKRINARAPV---LLVVVRDISARRQ
AEEELSRLQERLDLALAGLYDVNLT----------ERILGGDRQRI-PKTVDEWRQGIHPEPTVQRFADEVLAGNRDELEYRFRHQSGQWIWLLGKGFDF
DPS-GQPRRAAGTCVDITERKRSEASIHRLAYYDPLTDLPNRRLFLDRLVNAQAQ--RSGHIGAVLFLDLDRFKQVNDARGHEFGDHLLLDVTSRLHELL
RAEDTIARLGGDEFVILLAQLTQTEEALVAEKIRQALAAPYRLMDTDISSSVSIGITLFRGNEVTVHDILREADTALYRAKEHGRNCVRFFEVSMQQAAE
VRFSLEGELRQATKDNGLQLYYQPQFDA-EEHLIGYEALLRWPHPTKGMISPVVFIPIAEETGLILPIGQWVLTEACRFLAHIRR-CGHDLRMSVNVSPR
QFQQPNFVDLVQQALTDFSLPPQQLILEITEGVVIDDIQGTVTRMQELKSLGVQLSLDDFGTGYSSLAYLKRLPVDELKIDRSFIQDVCTDSNDAALVEA
ILAVCRHLDVTVVAEGVETLEQLQFLHARGCDSYQGFYFGMPVPSKTVVENLAIQ-----
>tr|K9W5Q0|K9W5Q0_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Crinalium epipsammum PCC 9333 GN=Cri9333_3998 PE=4 SV=1
---------------------------------------------------------IYLVDISD---RKRTEAALLKSEERYALAAMAANDGLWDWDLN
TNEIYFSCRWKSMLGYQENEIGNTPNEWL-NRIHPEESERVKAELAAHIGVTPRFESECQILHKDGTYRWVLSQGI------------------------
--------------------------------------------------------------------------------------------------AV
KDADDKTYRMVGSQTDISRRKEIEAQLTHDAFHDPLTGLSNRALLIFQLQHAIERAKRRKYSFAVLFLDLDRFKVVNDSLGHHIGDQLLIAFVERLVNAT
RSGDTIARLGGDEFVILLEDIQSDDATEIAERIKQRLISPFKINDYDIFTSVSIGIALDTTGSNKPEELLRNADIAMYRAKSLGKARYQVFDPQMHTRAI
TLLQIENDLRHAVEREEFVVNYQPIVALSTGKFVGFEALLRWHHPERGKVSPVEFIPIAEETGLIVPIGYWILRQACLQLKEWQERFQPPLTMSVNISCK
QFLESNLIDKIKSILLETKINPACLKLEITESVIMENAENAIKMLLQLKNIGVQIYIDDFGTGYSSLSYLHQFPFDALKIDRSFIDRMSKERDGGEIVQA
IINLAENLGVYIVAEGIETKEQNELLQQMGSNKGQGFYFSKPLDSKSLEELITEAPHW--
>tr|K9RRL8|K9RRL8_SYNP3 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Synechococcus sp. (strain ATCC 27167 / PCC 6312) GN=S
---------------------------------------------------------CYITNITE---RKLAQRALQESEERYAIAAQGANDGLWDWDLR
TNEIYFSDRWKQMLGLANVETSPSPETWL-EAIYPEDRTHVQIEIEQHLGVTPHLECEFRVLHPDGGLRWMRVRGL------------------------
--------------------------------------------------------------------------------------------------GL
RDERQQPYRMAGSLTDITEYRLIQEQILHDALHDAMTGLPNRILMMDRLGQAMQRAKRRPYLFAILFLDLDRFKVLNDSLGHLVGDQLLIGIAQRLVSCL
RAEDTIARLGGDEFAILLDEVGTDYACQVAERILTELRRPFILEGHEVFTGVSIGIAFNTQEHLQPEDLLRDADTAMYRAKSLGKDRYEVFSTAMRVEVL
ALLQLETELRRAVERQEFMVYYQPIVDLAQARICGFETLIRWQHPRRGVITPGEFMDIAEETGLILPMSWWVLETACEQMQQWSRQFPTGLAISVNLTGQ
HFAQPDLVSRLDNILTATQFSPHRLRLEVTETILMENTELAVQALESIRTRGIQIYMDDFGTGYSSLSYLHRFPIDTLKIDRCFISPLLHPIQGGGIVQT
ILTLAKSLHLNVVAEGVETEAQCQALQRMGCTYAQGYLFAPPLSAAHIEDILAKESLD--
>tr|Q8DL70|Q8DL70_THEEB Tll0627 protein OS=Thermosynechococcus elongatus (strain BP-1) GN=tll0627 PE=4 SV=1
---------------------------------------------------------CYLTDITE---RKRSELALRISEERYALAAEAANDGLWDWHIG
NRSVYYSPRWELLIGEPPGSLQPTIEEWW-RRVHPDDLEQLRQNIKEHLGSRPCFDCEFRIRHRDGSYRWMRSRGK------------------------
--------------------------------------------------------------------------------------------------AL
RNQKGQPYRMGGSMTDVTEYHLIQEKILHDALHDAMTGLANRVLLIDRLTQAIARRQRRPSLFAVLFLDVDRFKVINDSLGHLAGDQLLIGIGQRLRACT
RPEDTIARLGGDEFAILLEDLSDAQAMKVAERILMVLGRPFLLEGHEIFTTASIGIAFPWEDSQTAEDLLRDADTAMYRAKSLGKARYEVFSMTMRAQTI
ALMQMETELRRAAEREEFLVYYQPIVDLATLKMVGFETLLRWQHPERGIISPGEFMAVAEETGLILPISWWVMAEACRQMQRWAVIFPRKLRIGVNLSGR
HFQQADLLPNLRSILAETGFPAQRLCLEVTEGILIDNKEVAIATLEEIRAMGIGVSMDDFGTGYSSLSYLHRFPIDTLKIDRTFISALNSEESSATIVHA
ILMLAHSLRLQVVAEGIETREQYRALQALGCNYGQGYFFARPLSARQVEKLLARQSLP--
>tr|B0CE49|B0CE49_ACAM1 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor, putative OS=Acaryochloris marina (strain MBIC 11017) GN=AM1_5569 PE=
---------------------------------------------------------SYLIEITQ---HRRTEQQLRLSEARYAAAAKGANDGLWDWDLH
GNTIYFSDRWKAMLGFSEEEIGASPDEWF-NRIHPQDQDRVTEDLSAHLGDTPQFECEYRILHSNGEYLWFKGRGL------------------------
--------------------------------------------------------------------------------------------------AL
RNDQNQAFRIAGSQTDVTAYYSTRAQLEFKAQHDEMTQLPNRVLFMERLTHAFRMAKHQQRLFAVLFLDLDRFKIINDSLGHRVGDQLLIEVSKRLQQCL
RKQDTIARFGGDEFAILLDTVEDDEAIHVAQRILQALKAKISLEEHEVYTSASIGITVSSPDYQAPEELLQDSDTAMYRAKKQGKNCFEVFSSGMRAQVN
SQLQLETDLQRAISNNELHLVYQPIVDLNTENIVGFEALLRWNHPERGLVPPSEFIPVAEDAGLMVSIDWWVLTEACQQMAHWLNIYPGELTINVNISAH
QFLQSTFCEKVNAIIQETGMKPHHLKLEITEGVILSNAPNISEQLNNLKKLGIHLAIDDFGTGYSSLSYLYAFPLDVLKVDYSFVSRMDQD-NGLAIVRT
IVNLGQNLNMKVVAEGVETKIQQEYLQEMGCEFAQGYLFSRPLKKESVESILTNKNLP--
>tr|A0LBX0|A0LBX0_MAGSM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Magnetococcus sp. (strain MC-1) GN=Mmc1_2972 PE=4 SV=1
------------------------------------------------------------------------TQALEEEEQRLNSLFESAVDGILIIDAK
GIIQRYNAGACKLFGYTSKEALGKN---V-SLLMQDVVGQEHDLFITEGGTGNSREVE--ARHKDGSALPVKYAGEDYLKMANDHLESQALQQEVAEHQL
TQAKLFLVNQVFEKARQAIVITDHNNKILDVNPAYEALTGFQKQQVVGHDPAVGKSGRHDPAFYARMWRSLLSENHWEGEVWDRRSDGSIYPKYLSIDRV
LDRQGSVLNYVAMFQDLTEQKATEEELERLSHYDPLTGLPNRALFRNRLEHEFLVARRHNRSVALVLINLDRFKQINDSFGFTVGDRLLAMVAKRLEQLV
RDSDTLSRLGGDEFSIILAELRAEDAAIVARRTVALLEEPYDIEGQEVFLGGSLGVSIYPENAESLNGMIQCAERALVKAKEGGRNTFRFYSEEMNRHSA
EQVRLETELRRAVMQERFQLHYQPKLEIATGEIEGVEALVRWPRRDGRMFSPDAFIPLAEETGLIVPLGRWILKQACADVVAINAQRVRPLRVAVNLSAK
QFQQEDLEQMVLEALEETGLETQLLELELTESMMMGDVDEAINTMSILKGLGLTLSIDDFGTGYSSLSYLKRFPVDALKIDQSFVRDLERDSEDAAIVHA
VCNLGESLGMKVVAEGIETQLQMDFLRQLNCDTGQGYFIARPMPLAQLQDFLA-------
>tr|D5CSG3|D5CSG3_SIDLE Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Sideroxydans lithotrophicus (strain ES-1) GN=Slit_1666 
------------------------------------------------------------------------LGELNIQNEILQEQFRSQGDNSILSILK
AIVERLNPGLCSILLLDDGKHLGKG---I-APSLPD-------FYNTGLGVGTAAY------TKER--I---IQTHPYLSSTDQVLGTSRLASIAIERKR
SEEALHYSEKRFRDVNDAYVWMGTDMVYTYVSNRSVDVKGYVPDELLGHTPMEFMPVEDIPHVREIVNRAIASNTSFKLQHRDITKSGTLLWEEVNGVPF
FDEHGELMGLRGTGMNITDRKRAEEEIKSLAFYDPLTHLPNRRLLVDRLQHALASSTRSGREGALLFIDLDNFKTLNDTLGHDIGDLLLQQVALRLASCV
REGDTVARLGGDEFVVMLEELSETQTESIGEKILLTLNQPYLLAAHEYRNSPSIGATLFGNKPQSIEELLKQADIAMYQAKKAGRNTLRFFDPQMQETVI
ARALLERELSKALENDQFQLYYQIQMTD-LNEPFGAEALIRWIHPERGLIPPNHFIPLAEEVGLILPIGLWVLDTACNQIKIWEKASTRELVLAVNVSAR
SFFQDDFVTQIQTVLQRHAINPKRLKLEITESMMLNSIEQTIEKMNALKKLGVQFAMDDFGTGYSSLQYLKRLPLDQLKIDQSFVRDIATDSSDKAIVTT
IVAMAHSLNLDVIAEGVETEQQRQLLIESGCSQYQGYLFGKPAPIRQFEESLK-------
>tr|W9VI79|W9VI79_9GAMM Diguanylate cyclase OS=Thiorhodococcus sp. AK35 GN=D779_0986 PE=4 SV=1
--------------------------------------------------------------VTS---QKKAELARRQSQEILDLFLRHSPVYAYVKASD
NFHRMIGAAECDMEGKTMAELFPAE---FAARVAADDWR--------VVANAEVLCQEET--FKDRHYTSIRF---PIVQGQTLLGGY---TIDITERKL
AERQLQESELFFEQSRDAMMTLTPPCQLIQDRAEFVRLGA------WDLSPEFQPDGRRSDEKIHEVIETALSEGAYDFEWMYRRTDGTQFPATVLLTRM
TI--GGEVFLQGIVRDITAFKEQERRLEQIAHYDALTALPNRILLAERLQQGMAESRRCGRQLAVVYLDLDGFKTINDGYGHAVGDRFLRVIAERMRQTL
RQGDTLARLGGDEFVAVLLDLDAAASKALLRRLLAAAAEPLLVGDLLIQVSASAGVTLYPQAEVDGDQLLRQADQAMYQAKLTGKNRYHFFDAEYDRSAR
GFHESLEHIRAALAADEFVLHYQPKVNLRTGDVVGLEALIRWQHPERGLLAPGIFLPVVEHHPLAIKLGEWVIDRALTQMDLWREEGLD-LPVSVNVGAR
QLQQADFVQRLRRQLMEHRIPPGRLELELLETTALEDLSHVSQVIADCDALGIRCALDDFGTGYSSLAYLKRLSVGQIKIDQSFVREMLENTEELAIVES
ILSLAAVFRREVIAEGVETVAHGTVLQMLGGELAQGYGIARPMPAHEVVRWCRDWTPDP-
>tr|K6XAH8|K6XAH8_9ALTE Uncharacterized protein OS=Glaciecola arctica BSs20135 GN=GARC_0658 PE=4 SV=1
--------------------------------------------------------------VTN---EAESKESLVASEQLFRSIFEQAAIGVGISAAK
GTFIRINQRFCDMLGYSVDEMLNET---HFKVFSVENRE--------KILSGQEVTIEKRYLHKDGHTIWVMS---PTWEGTHPLNYIV-VVQDISLRKK
AEETLKLS-RVFSDTHEGIMVTDAQQVIVDVNPAFVKITGYSHDEIIGESPRILSSGKQSPQFYSQMWKSITEQGHWQGEVWNRTKQGELYSELLNISSL
TNEHDEVTHYVAVFSDITSIKQQQDKLNLMAHYDVLTHLPNRSLFIDRFHQAIAHSKRTGHKLAVCFLDLDDFKPVNDTYGHEAGDRLLIEVAERITGCI
REEDTLSRQGGDEFAILLNDIESSQYEITMQRIHQALALPYFIDGVQHDITASSGVTLYPSDNGDIDTLLRHADQAMYKSKLSGKHRSQLYNPDLDQRII
QKNLQLEEIEQALVNSEFQLYYQPKVNMVTGEVFGVEALIRWFHPEKGLIPPLNFLPYIDGSPLESRIGEWVINEALQQLDDWQQQGVE-VEVSVNISSN
HLLSSSFFVALEKSLAAHNIDPRCLQLEILESSALGDLNAITHIIETCQNLGVSASLDDFGTGYSSLTHLRSLPVNTIKIDQSFVRDMLDDPSDYSIIDG
VISLTKSFNREVIAEGVETTNHGLMLILMGCELAQGYGIAKPMPASAVCQWLNSYIPNE-
>tr|W6LYC9|W6LYC9_9GAMM Putative Diguanylate cyclase OS=Candidatus Contendobacter odensis Run_B_J11 GN=BN874_830013 PE=4 SV=1
--------------------------------------------------------------ITE---RKEAEEALRRSETRFRSLFEEVPSVAIGYGPD
GTIRYWNKASENLYGYTAGEVIGQG---LLELIAFDAIR--------SIVTSRRPAEELQLMRKDGSLVTVVI---PTLDK-SEVEFYR-LDVDLSELKR
AQERLRLA-SVFEHAHEGIMITDAAGTIIDVNKTFVEITGYSREEVIGHNPRLLKSGRHDAAFYAHLWQIIAEHGYWHGEIWNRRKSGQVYPEITSISAV
HNAKGVIIHYVGLFADISVLKESQQRLEKMAYYDPLTRLPNRALLADRLQLALSKAQREQRILAACYLDLDGFKPINDTWGHAAGDDLLIQVAQRLQSCV
RDNDTVARLGGDEFVVLLDDLHTDEGERALQRILEALSAPFALGAATVTVSASVGAAFFPSDGTDPDTLLRHADQAMYSAKQGGRNCYHLFDSEHNRRAQ
THRELLERVGQGLVAGEFCLYYQPKVDIRCGKVIGAEALIRWRHPEQGILPPDAFIAVVENSDLAQTVGDWVLGTAMKQMAVWAAEGLT-LPVSVNISAR
HLQQPDFAARVQALLAHHSIQPEWLELEILETTALDEIEQFSRIIADCRQLGVRFALDDFGTGYCSLTYLRHLPAQILKIDQSFIRNMLDSPDDLAIVRG
VIGLSSAFKRDIIAEGVETIEHGVLLLQLGCDYAQGYAIARPMPAEEVPGWVRAWRNPE-
>tr|C7RAL6|C7RAL6_KANKD Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Kangiella koreensis (strain DSM 16069 / KCTC 12182 / SW
--------------------------------------------------------------------------ELDTSKRFMQDIINTSPDVIYVFDFK
GLIIDGADRFARYLGYGGDEFES----WVLKIIHPDDSDILKERGAKIMSNDEVIKSEGRFKNAKGEWVWLKNHCKIVKRSQGEPLIEVGTISDITHRKV
MERELIYYRALVENAFDGIVLYDEKGRVQFLSKSVEKLLGYKAEDVTNKTGIDFIFPSD-LELVRKAWAMAHPNQIYRIYRLVKKDGGLIWVENTLINLL
--DDPVVSGIISNFRDISHKKSAEQSIYKISNYDALTELPNRHFLRQQIERQIKRYQKEPQSISLVYFDIVQLNGINNAMGHWVGDQVLHYVARVIRENL
DEFDLIARSGNDEFAVVLTEQEPFEVSQLVERILSSFENIIRIGELDLKVSIRAGIARFPEDADSAEDLLSRAEIAVGRVKN-LSTQYTFFQPQDSESIS
YRINLERELVQAIDDQSLELFYQPKVCLRTGVIESVEALLRWNHPESGYISPQTIVNIAEANSLIYKLTSWVVDNAIKQIKDWSEKGLN-TRIAVNLSAR
DIQRAGFEADIRQSLEKYQVDSTLLDIEITESAAMADMEHSVQTLRQLSDLGIGISLDDFGTGYSSISYLASLPVDLVKIDQTFIQGLKQASENQLIIKN
IIRLAESFKLVSLVEGIETVEQCRLLQKYNCDLGQGFLFSRPKSAKDIEPLLRKGYI---
>tr|A0A0D8HMH1|A0A0D8HMH1_9ACTN Cyclic di-GMP phosphodiesterase Gmr OS=Acidithrix ferrooxidans GN=gmr2 PE=4 SV=1
--------------------------------------------------------------------------ERRNRIELLGRIIDNSLNEVLIYEAS
LRFTWANRGSLINLGYSALELNE----MLA--IKPDFDASFMELASPLLKTKEILVFESVRQRKDGSRYPVEVHLQIAEVE---ERFFVAVVLDIT---A
-RIESRTAASLFTNSREGIAIADADFRVTAINSSFTRITGYSEEDAIDTYVAPTDSPMVFDGGFGEDWSKLLRNGEFDGDLWSHRKDGFGYLNRFSIRHI
RDDREMVVGYAGFYKDVTQERSNEERLRNAEMTDSLTGLMNRNSFMVATVELFESESKAMGGVALLLVNLDHFKAVNEAYGYSIGDVALQRLGSRFEAMI
DPKRPICRLGGDEFAMAVATKDPLDALDFAQSVLGLINQPIETEAGEVHLGAFIGISLYPDDSSDFESLFILANSALERARHGGSNKILLFDSSNIGAYT
RSLEIQKSFRRALSNDELYLVYQPIVSLRDGSIRSFEALLRWNHPKLGEVPPSEIIRIAERSGFIIPLGNWIISRALAQLASWHRDGVD-VALSINVSAI
QFLDGSLVSILGDKLRQYGLGNGVVEVEITETIAMTNVDESQAQIEKLKDLGVGISIDDFGTGYSSLSYLRKFPATTIKIDQSFTSELVENVEVSTIVES
VIRIADALGAEIVAEGVETIAQFEVLQRMGCANVQGYLIARPMLPEKVAPFIEKVAQ---
>tr|C3X9Q2|C3X9Q2_OXAFO Diguanylate cyclase (GGDEF) domain protein OS=Oxalobacter formigenes OXCC13 GN=OFBG_00956 PE=4 SV=1
--------------------------------------------------------------------------IRENRPVWMQDFLHEP--SMEHWQEI
AHFNWLSSAILP-------------------------------------IHKKG--------HVIGAIFLYSNHLNAFTES---QRLLLELMEDIDFALQ
-HFEKELAAQVFSQSSEAIMLLDSCSNIVMINRAFTHITGYSEEEALGKNPRMLASGQHDREFYSTMWESIEKEGRWQGEIWNRRKNGSIYPEWLLVQTM
RDSQNEVTHYIGTFTDLTERKETEERVQWLAHFDPLTGLPNRTLLHIRSNLAISLAHRRHEPLALMFLDLDNFKNVNDSLGHGIGDELLKQFAERLKNAV
RDQDTISRLGGDEFVLVLPNTDTGGATSIAEKLLAIAAEPYHIDPHELNLTASIGIAMFPADGADFETLSCSADTAMYRTKQNGRNNYCFFTAEMQAKSS
RMLELDSALRRALERNQFTLLYQPIMSLNYGVNVGFEALLRWEHPQLGSISPEEFIPVAESNGQIIPIGEWILRSVVKQLKEWVDAGND-RLVSVNLSAV
QFRDRRLTEQIAEILKENDLDPKHLVLELTESVAMEKPESAIVIIDSLKERGIKVSIDDFGTGYSSLAYLKRFAAHSLKIDGSFIQNVPHDPENMAIVGA
IVSLAKNLGITTIAEGVENIKQLEFLKETGCTAIQGHYFSRPMTAAAASDFLAVELV---
>tr|Q5QVY0|Q5QVY0_IDILO Intracellular signaling protein (2 PAS, GGDEF,EAL domains) OS=Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) G
------------------------------------------------------------------------------EKELLTSVETMANIGSFWYEPA
SGDLYWSPQLREIHGVAQDEPITYE--QAMAFHLPEYRENIEHLVEQSFQNHHSWSAESCLKDRDGRIHWIAITSITRTLKNGD-MALFGAIQDITVKKY
RLQQLQEQASTLDNLLDAVITIDNNGMIINFSVPAERMFGYSAAEVKGKNVSVLMPEPYEHRYISAY----QKTGHIIGEVQAKRKTGEVFPIDLAVTEV
T--YSGETQYVGVIRDITEQKENARKLEYLANFDEQTGLPNRHRFLD----LVEKRIESQLPIVVAAVNIDYFNRVNTIHGHEEGDRVIQLIAQRMRKTI
GDSGWIARDLGDRFWVGVMQDSTTSLA-IIDKLHGVLREPFKTAFQTHYLTASVGVSLSGG-DENASGLLSQADTATSNARHSGRDKVAVHRAEISNSVV
TDAETEVALRASLGKGQFECWLQSKVDTN-GVVRGAEALMRWRNEAGEIIPPDQFIPIAERFKLIIPMAKELLSQVAFVVRQLSDKGLN-DRIAVNVSPI
EFLQDDYVETVQRIFAEQNAPLNQLTIEITENLLLADPEIVEQTMSRLAELGVVFSIDDFGTGYSNFMRIQQLPIGELKIDREFVQLAEVNDKHMGLLLA
MLNMTKSLSVSSVAEGVETETQVKLLKENGADLLQGFYFARPVHFKDWLSERL-------
>tr|E6RKI7|E6RKI7_PSEU9 Sensory box/GGDEF/EAL domain protein OS=Pseudoalteromonas sp. (strain SM9913) GN=PSM_A0433 PE=4 SV=1
------------------------------------------------------------------------------QQSLFSAVEAMSKVGTWEYTIS
TGELNYSPEVYNIYGLDKHKPLTTT--QAIAHYAGEKQARIRDFFNRLQTHGLPYCEDFEFVDAHGNKKWVRTSGHPVFNDDHQVIKVHGAFEDVTLEYE
LKAKVDDKNAILNNLNDAVITINQQGVIVHCNSTALTMFGYKQNEMLGLSINNLMPEPYKHSYMRNY----ERTGEIIGQLPARKKDGTIFQIELSLTKA
V--NEQSVEYIGVVRDISEKLKAQDTIYNLAYSDPITGLKNKRWFERECRSLLQSASINNGYIYAALLDMDKLAQFNFKYGIEAGNEALILTAKKLSNAV
QGEYKLYKSGVDSFLIISANISNLSY-LIDSKILALDNFSHKISDLDVVLSASLGSTIINASRDSYSSMFDKLEYALKQAKKLSPFGYYFADLDALKRYE
RTNKIRYLLINVDKSDELTLVLQPQFINE-NTFNSAEALLRWDSEELGVISPGEFIPLAEESEAIIKIGDWVVDQVCKLLHEVSRAGKN-TCIAVNISAK
QIVAPDFKEKLLASVHKWQVSPRNLVIELTETTLVSDIELVKETMLELNKKGFRFSIDDFGTGYSSLSYLKELPISELKIDKYFVDGIMDDNSSKTIVNM
IIDMASALGVNSVAEGVEEPAQFNYLKQRGCNLFQGYLFSKPLPIAQWKERLK-------
>tr|A0A099L8G7|A0A099L8G7_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudoalteromonas sp. ND6B GN=ND6B_2907 PE=4 SV=1
------------------------------------------------------------------------------QQQLFNAVESMAKVGTWEYKVA
TEELYYSPEVYNIYGLETNAKLTPT--QAIEYYAGEKQSRIRQHFEHLQTQGLPYCEDFQFIDAKGHNKWVRTSGHPVFNSNNTLIAVYGAFEDVTFEYD
LQTRVAEKSAILDNLNDAVITINQKGVIVHCNKTALAMFGYEHSEMLGLSINNLMPEPYKHSYMQNY----EQTGEIIGQLPARKNDGTVFQIELSLTKA
V--NGESIEYIGVVRDISEKLKAQDTIYNLAYSDPITGLKNKRWFERECRSLLQSASLNSSYIYAALLDMDKLSQFNFKYGIEAGNEALILTAKKLSKAV
EGEYKLYKSGVDSFLIISTYPNRLCD-LIDSKILALANFSHKINDLEVVLSASLGSTIIDASKDSYDSLFNKLDYSLKQAKKLSPFGYYFADLDALKRYE
RTNKIRYLLINVDKSNELKLALQPQYINE-NTFHSSEALLRWHSQELGIISPAEFIPIAEESEAIIKIGDWVIDNVCKLLHQVGQLGKS-TCIAVNISAK
QIVASDFKEKLLASVQKWQVLPQHLIIELTETTLVSDIELVKETMVELNQMGFRFSIDDFGTGYSSLSYLKELPISELKIDKYFVDGIMDDSSSKTIVNM
IIDMANALGVNSVAEGVEETAQFNYLKQRGCDLFQGYLFSKPIPVEQWKERLQ-------
>tr|S5C6N5|S5C6N5_ALTMA Uncharacterized protein OS=Alteromonas macleodii str. 'Ionian Sea UM7' GN=I635_17515 PE=4 SV=1
------------------------------------------------------------------------------NLSLIDEISRMSHTGSWEFYPE
TEKLIWSPETYRIHDLPIDSEINIQ--KALDFIAPDYLAELTFAFENLRYKQCPYDIQCQIIDSSSSVRWVRASGKAELYKNGAVKRLFGAFEDITEYKT
ALILSADRASILNNINDAVFSIDTRGTITHCNDVALKMFGYTRGELLAQSVEVLMPEPYNHFYMRNY----METGVIIGQLPAKRKNGDIFQMELSLSES
S--DLGEKGFIGVIRDISERIEAQDTIYNLAYTDPVTHLRNQQWFHQRFKDLMLRASMNQEYIHILLLDIDNMAQINTRFGFGNGNYAIRKVAEQLLFVI
GHDYEIFKYGGDSFVVLSKKTYREDL-HVESALLSPRHFDIVINSVKWSLTASLGSAIFNPQGQSFESIINVIEQAVKRAKKSAPFGLCHISEDGFKEFD
RYLDIKSKLEQAIESDELSIVLQPQVTHD-GTVSSFEALVRWYSKELGPVSPGEFIPIAEESYAICEIGDIVLRKTLNVMSNFVKAGLN-TTIAINISAR
QIVMPDFINSLLSRVNQFGIPPHRLMLELTETALVVDIELVKETMLELAKFGFRFSIDDFGTGYSSLAYLKVLPISELKIDKYFVDDIGKDGKAAQIVDA
ILEMAKALNVTCIAEGVETVEQLNYLKGKGCERFQGYYFSRPEPEAYWAELKQ-------
>tr|Q47UF6|Q47UF6_COLP3 Sensory box/GGDEF/EAL domain protein OS=Colwellia psychrerythraea (strain 34H / ATCC BAA-681) GN=CPS_4928 PE=4 SV=1
------------------------------------------------------------------------------QYQLMSEIEKLAKIGGWDYEIS
TGKTHWTEETYRIYGLSLDEEITLE--QAAKFYSPEVQKTIKDVFELAVNQLIPYQVELPFIDAQGNHKWVKTTGQIRSNAQGIATHVYGAFEDITEQKQ
LLDSERSTSTIVDNLNDSIVTISSKGIILSANRMVEKTFGYLQQELIGQNVSILMPKPFQHKYMQNY----LKTGHIIGELPAMKKDGTSFPMELSISEV
L--HGNDKVFIGIVRDITERKKAEKDIHQLAYFDETTGVMNRYSLERDLKKCFDKSLLLNENITAMLINLDKFSQVNLIYGDDTGDVILKETATRLNERL
PSWVVTYRSSADSFYVLINPSAALDDARLAEKILKEIHQAITINQHVINVQASIGILNIPAKDIDYIDIKPLLELAVFNAKNKGGDNYVFASNNDTCSLK
RHSELSLAMKSNLFIRELNIVLQPQYSTQ-GKIVGSEALVRWQSASLGGISPVEFIPLAEKNGAIIELGNWIIDKTCSLLAQRRVFSKT-SPISVNISAK
QIAQPNFVDNLLTSLDNYQVPYSELVLELTESALVTDLKLVVSKMELLKSKGILCSIDDFGTGYSSLNYIHHLPIIELKIDKCFVDDIKNDD--VPIINT
ILQMAKSLKLRVVAEGVESKAQLNYLADHGCDVIQGYYFSKPLNSTQWLDKWK-------
>tr|A3JAM8|A3JAM8_9ALTE Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Marinobacter sp. ELB17 GN
------------------------------------------------------------------------------NEEMLKSVINANNIGTWRLNLQ
SGELTINEKWAHLLGLMPTDR--------LAYCISEL-------EKHSMGQVPAYEADIRMKHKNGEWVWINTRGQ-VLSSDGKTEWLIGTHFDINDRIT
AQRKSNEQSAIVESMQDGVVTISNKGVIRTFNRGAECIFEYGRDEAIGLDVNVLIDYLN---YISNY----ISRNTAQRELDAIN-YGTVFPIEIGMTQM
P--PLGDIDFVVIVRDITQRKKREDEIRQLAYYDPLTRLPNRRLLKDRLQQVIANCGRQSRYAALFFLDLDNFKNLNDSLGRTKGDLLLCQVAARLIESV
RHGDTVSRLGGDEFVVLIEGLSSRNE-AAAGKINVQLTQKFDLDGSPYNGSASIGVTTFNSNDSSLEDLLKQADMALYKAKAADHSSVHFFDPQMQVVAS
LRAAMQQDLYEALRKNQFQLHYQKQIDQHEG-LIGVEALLRWAHPTKGFISPAQFIPLAEETGLIVPIGEWVLREACQTLAQWAPAKAN-LTIAVNISVV
QFNKKDIVHTVLNALNASGAKPHNLKLEITESLLASDVENVKVKMLELQRHGVTFSIDDFGTGYSSLFYLKQLPLHQLKIDQSFVRDIINND--QAIAQA
VITLAIAMHLNVIAEGVETEAQRAMLQDLGCGAYQGYLFGKPCALQDLFIETQ-------
>tr|V4HW03|V4HW03_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain protein OS=Pseudoalteromonas luteoviolacea 2ta16 GN=PL2TA16_04546 PE=4 SV=1
--------------------------------------------------------------------------------------INRTDVGMIVINCR
SE-IVFINDWIKAHCVFPELPSRLN--RAFPFYRDKQ----STKERTLISQVV----KVKPINVDGQFCLIEI----IDISVNRET---ALHQLASEANL
KADQIEAQEGIFESVKDAIIIVDAGGLIQMFNHTANELLNSATGTLSNINLHQFLPLSEGGNQMAA-------------------GKDSSFSAELSVNTV
E--LSEQRHFVVVLRDITERKQYEQQLETMAKFDELTSLPNRTLLMDRIQSAIGRARRFDNNVAIIFLDLDRFKIINDTLGHDTGDKLLQLVATRLSEGI
RELDTVARLGGDEFVILLENLEHEHA-AVAEKIVSVFESAFDIDGHQLFVTGSLGIATYPENGETAYDLIKCADTAMYAVKDSSRNNYMFFSEKMNENAK
KRLELEAELRVALKEQQFSIVLQPQLSPDNKILHGAEVLVRWYHPTKGFISPVDFIPIAEDSGFIEQIFDTVLTQACQFLAEYKILPPH-FRMGVNISPR
QFSSETFTQRFMTVLERYQLETRYFELELTEGMLMKQTDKTIALLRSLVEKGFVISIDDFGTGYSSLAYLTRFPLHTLKIDRSFIVDLPDEA--ALVCKS
IIGLAKNLGLILIAEGVETQQQNDFLAAENCDVIQGYYFAKPMPVDEFVNWFD-------
>tr|A4BB01|A4BB01_9GAMM Uncharacterized protein OS=Reinekea blandensis MED297 GN=MED297_11380 PE=4 SV=1
-----------------------------------------------------------------------------------ITLLNQI----FKDTC-
--QLHFEQDSLQALALLKQHPQ-------VIFITVH--------------SSPEF--QVRCLNE-GAVDFIIKPLNP---------------KIVEARVR
TQLKLKEREITLDSIGDAVISTDKDGRVRYMNPAAELITGHTNIEAQGRFIEDIMPLRIDGAHVNPL----RLAISRVGNCQL--------------LIS
D--SGDVIGGVIVFKDIDESRAMVLKMTHSLQHDQLTNLPNRFLLMEHLTAAIATNKGQQTKLGLLQLNIDRFKLINEEFGFAFGDSLLKKVANFLKQQL
SGEETLSRHNADEFVILVPKLNDSEL-A--LQLKEQLGLFSQTLSGIVNLTACIGLSLYPDDARDAQSLILHADSALKRAKENIHQGICFYSDEMATQFM
TRRKIYKHIKAAVSNQSVITLYQPMVNSQSGRVEAVEALMRISDDEGNIVPPIDFIAIAEDTRLILPLGEQMIVNSLKQQQKWQKAGRN-IRICLNISPV
QFREPGFVGFLTQTLQTMQIDPRMIELEVTESLMLETHAQLTRDIQTLRDMGITLSIDDFGTGYSSLSYLKDLPVDVLKIDKSFVALAETGD--TVLIKT
IAELANNMGLSSVAEGVETEQQVHYLQNLGISLLQGYYFSKPQPAEDVLFEYP-------
>tr|C0QRL3|C0QRL3_PERMH Signal transduction response regulator OS=Persephonella marina (strain DSM 14350 / EX-H1) GN=PERMA_1542 PE=4 SV=1
------------------------------------------------------------------------------ERSLFETISKVAPIGIFLQ--R
KGRLVFVNKKVEEITLLDMDDI-------LLIVHPEDRKKVKEVRNKGIKKFANY--RIKIITKSNRIKWIHINSETVSYHY----SGIGTIEDITKEVH
LEKAKELRIVLLKAVVDTLISVDDFSDVFIAEENGQIVPKFDKGSVITNLFNRL-PERENKDYIRDV----EE------------EKDYFFDEEISIYRE
I--S-DDVGFG--I----RYIQQQKDLFHKEFFDTLTDLGNRKLLLSELKELVR----EEEEFYLVFLDIYNFRFINEIYGEKVGDLLLREIADTLKEFL
-DGYKIFRSGSDTFTVVVRDKDI----SVLEKIRLAFTIPFSIEDHIIHLDFNVSVVKYPEDGKSETDIYIKGERTLELSKSKGKNHILFYNEKDYQKVK
TIKEIEEKIETALIENQFTFNLQPVVDFKTDSVIAAEALIRWKTPEGEYIPPSEFIPIAEKTGQIKDIDNLMLVKVNDIINRWKREGLP-VKISVNVTPQ
NIEEIIYKIKSTNKMVFFKVNSKYIIMEITERDLLD-LYRQKKDIDNLRKMGFEISIDDFGTGFSTLKYLANINVDSIKIDMSFIKDMLINV--HKLVQS
IINIAKIFNIKTIAEGVETEEQYIELKKLGCDRYQGYYFSPPLEPEEFVKFLK-------
>tr|A0A091ARH5|A0A091ARH5_9GAMM Uncharacterized protein OS=Arenimonas malthae CC-JY-1 GN=N790_12150 PE=4 SV=1
-----------------------------------------------------------------------------DAEHRLTVALNAAALGTWENHLG
TGEMRANARWFEMLGLNPHRDAEAATTWR-ERLHPEDAPLLERAYARLADPAKHFEIDMRLRHAEGHWAWIHSRGMVLRDTQGQPLRLAGVHLDMTQQRR
DEAQLRIAADAFANSHEGILICDGDGVILSVNRAFERVTGYTAEEAVGRPPSMLSSGHQDEAFYQRMWEEIAQRGRWEGEVWNRRKSGEVYPEWLAITRI
RHEGGRV-NYLGQFIDISERKQVQSRIEELSRTDPLTGLPNRRSFGEFVAARLAGAQ---PRLAVLLFNIDRFKQVNESLGYGTGDEVLKMLAGRLAAVF
GEGSTLARVSGDEFAVALPGAGEAEARAVVDKLQLDLQQPFEIAGQRLVLGLSAGLALSPEHGTEAELLLVSATAALNLSRSEGERRLAVYSPRQPGASL
RRLTLESQLRLALQRRELFAVYQPQVALADGRLVGLEALVRWRHPERGVVPPGEFIPVAEEAGLIAAIGDFMLRESCQAAVRMHAAGLPPVPVSVNIATG
QLRRADFLPQVLSELESSGLAPALLEIEITESMLMADVQSTISLLAALRERGVRVAIDDFGTGYSSLAYLGRLSLDRLKIDQSFVRDLRVPGPAEGIVRT
VIALARSLRLNTLAEGVEQAEDAERLRALGCDDAQGYLYDRPLAEADLLA----------
>tr|A6Q231|A6Q231_NITSB Uncharacterized protein OS=Nitratiruptor sp. (strain SB155-2) GN=NIS_0426 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------------------AGIKNVEDIKL-HILDQLYRMTELYGLIELQQKEKA
LTQELKLLSHTFNA-HEAITITDASGKILRVNKAFEDITGYKAEEVIGKNPSILKSGIHDKEFYQQMWDAIKHQGYWKGEIYNKKKDGTIYPEVLSITAI
KDENGEISNYVAHFFDVSELKEAEDEIKKRIELDLLTEVFNRKKMVEELEVVRKNAIKEGYCNAFFFIDLDNFKYINDSYGHFVGDEVLKEVAKNLKAVV
KDGDIVARIAGDEFALILVDLAKEQATLVAEKLISEYSGQKQIGGYDLDINFSIGIYIFPAGEQSVDEIITNADIAMYNSKKSGRNRFTFYNEALDLESK
RFLVMKKAIERGLKEKEFELYYQPKVDASNEKIVGMEGLLRWNSKEYGLLFPDKFFPYTRGNRLLYEITDYVLDEALQMIQILRESGYLEVKVSINISAE
QFINRKYVETLLKKIQNSHY-ADGLIFEIVEDALIQNVEYAKDLIKTFRKYCVEIAIDDFGTGYSSLSYLRDLDVDEIKIDKSFVLDLFEHQNDKL-VEK
IIEIGKIFGYKVTAEGVENAQSMQFLKERGCDYLQGFYFSRAVRKEAILRML--------
>tr|W0SEN5|W0SEN5_9RHOO PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_00394 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------PFWSDLSVAPVLDGDGRATHFVGITRDITESRQ
LQQELRIAAKAFES-LHGIMVTDAKGIILRVNPAFTELTGYSADEAVGQTPALLKSGKHDREFYADMWRQLAATGAWYGEVWDRRKNGEIFPKWQTISAV
RGLDGQITHYVAAFSDISASKAAEDEIRHLAFFDPLTQLPNRRLLLDRLQHALAASARNRHHGAVLFIDLDNFKNLNDTLGHEKGDLLLQQVAVRLTECV
REGDTVARLGGDEFVLMLEDLSERDAEVVGEKIVEALNLDYQLGIHEYHCTPSVGVTLFCGHDTGVDELLQQADLAMYQAKAAGRNALRFFQPDMQEVVT
VRSALEADLRKALREGQFALFYQPQVGAE-GQLTGVEALVRWHHPERGLIAPNEFIPLAEETGLILSLGLWVLETACARLAIWGDSGKAHLTMAVNVSAR
QFHHQDFVDQVLATLEHTGANPQRLKLELTESLFLTDVEDTIVKMTALKDAGVSFSLDDFGTGYSSLSYLKRLPLDQLKIDQSFIRDVLTDPNDATIART
IVALGHSMGLAVIAEGVETEAQREFLASHNCQAFQGYLFGKAEPPERIPH----------
>tr|A0A0B2D933|A0A0B2D933_9GAMM Sensory box/GGDEF family protein OS=Serpens flexibilis GN=SF06_04540 PE=4 SV=1
------------------------------------------------------------------------SESLRDSERRYRLLAENMRDVLFILDDE
MQTSYISPSVQQLSGYSADWLLRNG--VQRLMAHPEQLAELRQRLAEALRQEPQQRYLFDCQCHDGRILPIELRTSLMWSAAGRFEGVLGVCRDVSQQRQ
TEQELRMAATVFANSTAAILVADRQGNIVQVNEAFSRISGYTSDEVLRRHATLLTANRHEAEHLAELLERLDQDGRWEGELTLQRRSGESYSAWLGIAAV
PDGAGALANYVCFFNDMSERKASEQHIHRLAYYDALTLLPNRTLFQERLQQALQAAARQRHWVVLMFLDLDRFKPINDSLGHAAGDLLLKDVALRLSACV
RHDDTVARMGGDEFTLLLSPLDDTEAIAVAQRILASLSHPFLIHGREFFISASIGIALSPQDGSLSSQLMKNADTAMYHAKDQGKDNYQFYQANMNATTL
QRLELESDLRHAMEEGQFLLYYQPQLDARAHRLTGVEALLRWQHPRRGLVSPGEFIPVLEELGLVVQVGEWVLAEACRQIRAWQLQGLPVPKVSVNLSAR
QFADGMLGARIADILASSGLAPSSLELELTESILMRDVGAAMQVLTVLKQMGLSIAVDDFGTGYSSLNYLKQFPINVLKIDRSFVDGLPDGEQDAQIARA
IIAMAHSLNLSVIAEGVETREQLEFLREHGCDEIQGFLLARPLSAQALEDKLRN------
>tr|W0SBD5|W0SBD5_9RHOO PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_00393 PE=4 SV=1
--------------------------------------------------------------ITE---RKVAEAALLKSQTLMASVLSSASYSIIATDLQ
GLITVFNRGAETLLGHAAEDMVGRQ---DPGVFHDPDEVAYAELLARTRVTGEPDEREWTYIRKDGTRIPVLLSVTAIRNQQGEITGYLGVATSIEERRQ
AEANLRVAAIAFES-QEGMMITDPKGVIVRVNQAFVRLTGYSADEAIGQTPALFKSGRHDAEYYRRMWTTLRESGYWQGEIWNRRKNGKIYAEMLTISSV
VAPDGQVSNYIGTFSDISRNTEAEAEIHRLAFYDPLTQLPNRRLLIDRLQQAIGASARSGREGALLFIDLDNFKILNDTLGHDHGDLLLKEVAQRLRACV
RESDSVARLGGDEFVVMLEGLDEENAKAVGEKILTELNETYLLGEHRHHSTPSIGITLFGEKQEAVDELLKRADFAMYQSKAAGRNTLRFFDPQMQAVVT
ARASLEAELRQALQDGQFLLHYQAQVDA-TGRMTGAEALVRWQHPERGMVPPGEFIPLAEDNGLILQLGHWVLQAACAQLVRWARQGMNHLTVAVNVSVR
QFHHIDFVEQVLAILDHTGADPRRLKLELTESLLLTDVEDIIKKMTALKVKGVGFSLDDFGTGYSSLTYLKRLPLDQLKIDQSFVRDVLTDPNDAAIAKA
IITLGQSLGLAVIAEGVETEGQRGFLASHGCNAYQGYLFGRPVAAGSLEAA---------
>tr|W8G2Y5|W8G2Y5_9GAMM Uncharacterized protein OS=Thalassolituus oleivorans R6-15 GN=R615_14740 PE=4 SV=1
--------------------------------------------------------------VTE---DVEKQEQIVESERRYRLLAENMKDIVWATDAE
LNFNFVSSSVTRVLGYQPDELLRDG---VNTIFTKADIRTLFKMMRHAIQRRAMIRQDMVATSKTGSEIKLELQASLLWNDNGELQGMLGICRDVTESRR
IEQELQLAAEVFENSNEAILITDRQLRIANTNKSFTHITGYSQQEVIGQTPFLISSERHNTDFFEQIGESLVVDGYWQGEIFYKRVNNDIRTGWAGVSAI
RDHNHEVQSLIIIMSDITERKVIEERIHRLAYFDPLTGLPNRSQMHERLESMLASAREREGSVALLFIDLDRFKPINDSMGHPAGDQVLKQVALRLSNCV
KKQDMVCRMGGDEFTIAVGEQSDEAAVRIGERILHALNRPFLLGQREVFISASVGIGIYPNDGGSVIELLKNADMAMYHAKDMGRNNVQFFNASMNKKAV
QLLELENDLRHVLARQELELYFQPQYDAASASPVGVEALLRWNHPSKGMIAPGVFIPIIEDTGLIVPIGQWVLEQACLQFADWKEYNIALERVAVNVSAR
QFKQDNFLELVKDAIFKSGLHPRQLELELTESILMDDVAHTLETLNGLRRLGVKTAIDDFGTGYSSLNYLKQFPVDTLKIDRSFIQNLPANTDDAQITRT
IIAMGHNLGMGIIAEGVETSEQLEFLVKAKCEEVQGFFFSKPIPERELLEMFE-------
>tr|R4YU65|R4YU65_OLEAN Uncharacterized protein OS=Oleispira antarctica RB-8 GN=OLEAN_C34270 PE=4 SV=1
--------------------------------------------------------------VTE---EAEQQIILVENERRYRLLAENVIDVIWSVNSK
LDFTFISSSIYSMLGYTPDEIYRGA---ITGVFNRGDLIKMNK----ALKTGSIFKVDMKAACKNGQQLIIEVQANYLWDENNNLEGIFGIVRDVTKTRQ
TERELILAGQVFDNSTEAIVVTDNMGRIINANPAFFEASQLTLDEVRGLRPEIINSKFHGSDFYTDVGQAILQDSYWQGEVHYLRKNGEERVSWTGVSAT
RSRSGKVQNLIIIISDITERKVIERRIHRLAYFDPLTGLPNRSQMYERLDKMVTYARQSNTHIAVLFLDLDRFKPINDSMGHPAGDQVLKDVADRLQNCI
KKQDLVSRMSGDEFTIALSDQKSDNAVKVGERILHALQQPFFIEQRELFLTGSIGIAIFPHDGSTVTELLKNSDMAMYHAKDGGRNSVQFFDEQMNKKAV
ELLEMENDLRYAIERGELELYYQPQYAAADCSMQGVEALLRWHHDTKGMIPPSHFIPIIEDTGLIIPIGEWVLRQACSDMAQWQKDNIAVDRIAVNVSAR
QFKQPGFIDLVKEVITETSIDPNQLELELTESILIDDLEHTLDVLTQLRAMGVRMAIDDFGTGYSSLNYLKQFPVDTLKIDQSFIQNLPHNNDDAQITRT
IISMAHNLGLGVIAEGVETKEQLEFLQQVQCEEVQGFYFSKAIPASALVEMIK-------
>tr|Q1N2J6|Q1N2J6_9GAMM Uncharacterized protein OS=Bermanella marisrubri GN=RED65_16276 PE=4 SV=1
--------------------------------------------------------------ITE---EEDAKIQLSFSERRYRLLANGISDIVFTLNKK
LELSYISASINKMLGYDSDQVMREG---LSLFLITESVNKLIQALERAL-FKQVRTMDLDAQTFSGVPVILEMQSSILRNESGAIEGILATCRDVTQRRF
IEHEARTASEVFENSSEAIMMTTSTGLISRVNRAFTHLTGFDGQHVIGVNPQFIAKDVS-HQTMQDIRDALLVDGYWQGELDYINRKGEKHPSWTGVTAL
KDEMGQIQSHIIISSDITHRKQTEARIQHLAYFDPLTGLPNRAQMHEALDRLMAK---EESQLALLFIDLDRFKPINDTMGHPAGDQVLKEVASRLKEAV
GAKNLVSRIGGDEFTVIMATLPEEQIIDVSERILHQMMQPFFIEDRQLYLSASVGIALYPENALSGTDLLRNADTAMYHAKAMGKNNFQFYAEEMNEKAM
ERLELENNLHLALQRDEFELTFQAQWDIKHNCICGVETLLRWHRPDIGLVGPDKFIPIIEETGLIVPIGEWVLRRACEQIMDWQEAGYVIPKLAVNLSAR
QFKDAQMLDRICRIVDETGVDPELIELELTESILMDDIDRTLAVLNEARKMGFGLSIDDFGTGYSSLSYLKQFPVSQLKIDKSFIQNLPYNQEDGQITRT
IVAMANNLGLGVIAEGVENESQRQFLKTIGCYQVQGYMYSHPVPADLFAQDFL-------
>tr|A0A069RHT9|A0A069RHT9_CLOLI Diguanylate cyclase/phosphodiesterase OS=[Clostridium] litorale DSM 5388 GN=CLIT_10c04320 PE=4 SV=1
-------------------------NHEWSIKVSGSKIGMDI-VHRNMIFHAIAAAALFVLFLANISELKRLRKELQRKEERYTRAVDGVNDVIWEFDIE
NEEFFISDNWTRITGRSIDVRGNLL-EQLKEQLHPADIKNSLKVFRDAKYGRDSYSHDFRVSHALGGYKWMHIRGQS-----------------------
---------------------------------------------------------------------------------------------------Y
RDELGAVIKVAGSIADITKKKESEEYVRYIAKHDELTGLLNRRSGIEALESNI----DLETDCAVIFVDIDNFKRINDTLGHGFGDNILVQISIRFKELG
SRQVTLSRFGGDEFLFIVYDLLDCKLGDICNMILDEIRHPFNIDGKHIYITASMGIAVYPDDGEDKITLLKNADAAMYSAKETGKNRYQFFNSTIGEEIS
RKADIEINLRHAVELGEFELHYQPQHSLKDDAITGFEALLRWENAQLGRVSPLEFIKVAEETGQIIEIGRWVFEEALEKVKQMCNSSSECKKIGINISAT
ELEEESFVDNIKAKIAKYGVDSKNIEIEITENVLMKDFERNSKILSELSTMGFKIALDDFGTGYSSFSYLQSLPVDTLKIDKAFIDNINVSEKGTSIVEG
IIRLAHSMKMNVIAEGVEDKDKLEFLKRAGCDIVQGYYYSKPMKEDELESYIEM------
>tr|A0A037Z4V1|A0A037Z4V1_CLOTT PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Clostridium tetanomorphum DSM 665 GN=CTM_14188 PE=4 S
-------------------------DNNLKIQVSSKQNYIKN-ILDELVAATITLVLLILFIFYKIDELTKLKDKLRISEERYKLAVDGANDAIWEWNIE
KGKLFISDRWENIVGYSLNENISMK-KIIKTIIHPEDKKIAIEDFNKYIRGESLYKSTFRVKSSDGDYKWIFNRGKA-----------------------
---------------------------------------------------------------------------------------------------L
WNNEGRAVRLSGSLTDITDRKKSDEKMLQMASYDQLTNLPNKRLFLNNLQNHMNKREDSDENIAVIFLDLDNFKKINDTLGHNYGDQLLKVVAGILEFCV
GETSAVARVGGDEFLIYLYCDKDNNVINLCEEIKSMLNNPLEIGRKHMYTSASMGISIFPQDSIDVNILLKNADTAMYRAKNFGKNNYCFFTKDMRDEVV
RKTEIEKGLREALENNELQVYYQPQIDVNSRRLVGFEALLRWKSKELGWVSPAEFIPIAEETGLILPIGEWIIKTACNQHAEWMKKGYKPFIMAINLSTV
QIQHKDFGKVVRKIIEESKVDTKYLEFEITETILMESLDCSMELLKEFRDLEIKVALDDFGTGYSSFNYLKSLPISTIKIDKSFIDNINFNSNDKDITHG
IIKLAHRINMDVIAEGVEKEDQVWLLQDMKCDRIQGYYFSKPLALQDAENLLTK------
>tr|A0A010Z929|A0A010Z929_9CLOT PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Clostridium sp. ASBs410 GN=K413DRAFT_0468 PE=4 SV=1
-------------------------DTYWTLKLSKEGNSINT-NGAVIGFISVLVLFLMGVLIYNIQHLANLHKELERLKESYTLALDSANDALWEWNLI
TDEIITSDKWIDITGNAPKGHGLRG-ILQEETIHQEDYQAVLAEFDSCLKGEREFHREYRIKNKDGSYTWVLNKGKV-----------------------
---------------------------------------------------------------------------------------------------Y
FDGEGLPGKLAGAVSNIEERKHRESKMEYMAFYDMLTGLPNKVQFMGTLEDTLRCIGEGLCRYSILMIDLDNFKIHNDLLGLDFCDQLLKQVGNRLTQIL
GQENMVARFGGDEFLILIRNHQDKEVEMICQNILSIFDSPFVLMEKSVYLSVSIGVVHGLEAGQTANNVLRNADTALNKAKESGKNQYCIYDAQMHDEII
RKSDVEVCIREALAKDNLLIYYQLQQDLSKDEIRGVEALARLNSEELGMILPFEFIGVAEYTGLIIPLGSWILKNACKQGKAWIDSGCKIGRLSVNISVH
QLRNENFYDLVEGILKETQFPVNQLELEITESVLLELSQDNIEILKKLRSLGVSIALDDFGTGYSSLNYLTVLPIDILKIDKSFLRRALESETEHRVIKS
ITELAHGLNLKVVCEGVESAEQREILKEMGCDYIQGYYFAKPGDAKSIEKWFQK------
>tr|D9R0J6|D9R0J6_CLOSW Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Clostridium saccharolyticum (strain ATCC 35040 / DSM 2544 / NRC
-------------------------DTYWTMKLSKEESSINA-NGALIGFISLLVLFLMGILIYNLQHLASLHKELERLKESYTLALDSANDALWEWNLI
TDEIITSDKWIDITGNALEGHGISG-ILQKETIHQEDYPAVRAAFDACLKGEREFNQEYRIRNRDDTYTWVLNRGKV-----------------------
---------------------------------------------------------------------------------------------------Y
FDGEGLPGKVAGAVSNIEERKQRESKIEYMAFYDTLTGLPNKMNFMSTLEETLGSIENSLCRDSILMIDLDNFKIHNDLLGLDFCDQLLQQVGDRLTGIL
GQKNMVARFGGDEFLILIRDCKDSEVKKLCQNILSIFGAPFVLMEKSVYLSVSIGVVHCMEAGQTANDVLRNADTALNKAKESGKNQYCIYDAQMHDEII
RKSNVELCIREALAKDDLLIYYQPQQDLFRNKIRGVEALARLHSKELGMISPFEFISVAEYTGLIIPLGSWILKNACKQGKAWIDSGCKFGKLSVNISVH
QLRNENFYDLLKEVLNETQFPVNQLELEITESVLLEFSQNNIEILKKLRSLGVSIALDDFGTGYSSLNYLTVLPIDILKIDKSFLGRALESETEHQVIKS
ITELAHGLSLKVVSEGVETAEQKQILKDMGCDYIQGYYFAKPGDAKSVEKWFRR------
>tr|F5Z5B3|F5Z5B3_ALTSS Sensory box protein OS=Alteromonas sp. (strain SN2) GN=ambt_16260 PE=4 SV=1
--------------------------------------------------------------------------FSQQSQKKLELALWASQESFWDWQAS
HDIIDIRA-F-SLNSESESTWSGTPIDLM-ALVHEGDLENQFQWSM-ALHGGERIELS-FRMSIQGQLQWVRLRGRVLKRSSGEALQIVGTTRDITQQRE
AEQSFQLMASAFANSREPMLVLSPSLSINECNEAFVKLVGAPDKMACNLNLNDLLKEKVNT-------NSLEHKKQLRFESVIVPRVGENTAVDISVSVF
DNYLEASSSLIATMRDISERKRNEARLKQLALYDELTGLNNRSALRDIFQQL----FDSHGDFLVVFIDLDGFKAINDTAGHEKGDVELQRVAALLTASF
GPFGDVARWGGDEFIAVLSRQNIWAVEKSEALIRLIEEDVVVTKKVELKLSASIGIAKFPEHNDSIEGVVQCADAAMYHAKKLGKGQVNVYEDGLYERMS
QQVSMVNDLRKAIEKNLLDYYIQGKYD-LQGNLKGGEVLCRWISGLHGVVPPLVFIPIAEAHDLDCQIGLQALEAACDYIAMMEAQQGESIPLSINISVN
QMLDTDFPAQATKICNDSSVRTNMIELELTESIFIRDEKAALAALNSLREVGFRLSLDDFGSGFSSLSYLRNFHFEVVKVDRSLVKDIHNNSKANALFCG
LVAMLNRLQIEIVVEGVEQESYLPFMENADVNLMQGFYFDKPMPYDQFLARH--------
>tr|A0A075NVU8|A0A075NVU8_9ALTE Histidine kinase OS=Alteromonas australica GN=EP13_02165 PE=4 SV=1
--------------------------------------------------------------------------QSQQEQKNLELALWASQESFWQWQAD
TDMMDIRA-F-SLHADSVSTWSGTLIDLM-SRVHEDDLESQFHWSM-ALHGNDKIELS-FRLNVQQGYQWVRLRGRVLDRSAGEALRIVGTTKDITQQRK
AEQSFHLMASAFASSREPMLVLSSALLITECNEAFIRLIEAPVKDACGLNFNELLSKRVEQ-------KNLAAHKQLRFESQVTTLAKQEIPVDVSIALF
ETYMQTSSYLIATMRDISDRKQNEDRLKQLALYDDLTGLSNRNALRGYIEDI----YEGQSSFILVFIDLDGFKAINDTAGHEKGDNELQRVASLLIHSF
GQTGKVGRWGGDEFIAVLPDTDIQAIQIANSLIQKIEAKVIPVHQTELILSASIGVAHSLEHGDSVESLIQCADAAMYQAKKLGKGQVFIYKEGLYESMT
QQVSMVNDLRRATENHLLDYYVQGKYD-LNGKLKGGEVLCRWISGLHGIISPAVFIPLAEEHNLDHLIGLQALEAACDYISMMESQQGTAVPLSINISVN
QMLDPDFPPQAKAICKASDVYPSMIELELTESIFIRDERAAVQSLNSLRDAGFRLSLDDFGSGFSSLSYLRSFQFEVVKVDRSLVKDIHQNSKAHALFTG
LVAMLSSLEIEIVVEGVEQESYLPFMKEADIGLMQGFYFDKPMPYDQFLAKH--------
>tr|A0A0B3YDY4|A0A0B3YDY4_9ALTE Histidine kinase OS=Alteromonas marina GN=RJ41_04735 PE=4 SV=1
--------------------------------------------------------------------------KSQSAQKDLELALWASQESFWNWEAE
NDIMEFRS-F-SLHSESVSTWSGTLIELL-ERVHEDDLDGQFHWSM-ALHGNDRIEFS-FRLKLDSDFQWVRLRGRVLKRKAGEALHIVGTTKDITQQRK
AEQSFHLMASAFASSREPMLVLSPDLVITECNDAYIQLIAAPFKEQCGLDFNQIFIEKVDK-------VQLALDKQIRFESKVKTQNGEIKVVDISVALF
ETYQQTSSYLIATMRDISDRKRNEAKLRQLALHDELTGLSNRNSLRESISGL----VQKEQHFILVFIDLDGFKAINDNAGHERGDIELQRVGALLTAIF
GPIGEVGRWGGDEFIAVLPNQNVEIAERSERLISQIEEDAITVKTSELRLSASIGIAEFPEHSDNLESLVQCADAAMYRAKELGKGQAFIYESGLYESMT
QQVSMVNDLRRTVENHLLDFYIQGKYD-LNGELKGGEVLCRWISGLHGVVSPAVFIPIAEEYKLDSAIGLQALEAACDYISIMESQQGDAIPLSVNISAN
QMLDPEFPNQAMSICMDNDVSPEFIELELTESVFIRDEKSALRALNTLRDHGFRLSLDDFGSGFSSLSYLRSFQFEVVKVDKSLIQGIHQDSKANALFNG
LIAMLKSLQIDVVAEGVELESYLPFMEQADIQLMQGFYFDKPMPYDQFLARH--------
>tr|A0A010PB33|A0A010PB33_9ALTE PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Alteromonas sp. ALT199 GN=H978DRAFT_3084 PE=4 SV=1
--------------------------------------------------------------------------KSKSAQKDLELALWASQESFWNWEAQ
SDIMEIRS-F-SLHSESVSTWSGTLIQLL-ERVHEDDLEGQFHWAM-ALHGNDRVEFS-FRLMLEKNYQWIRLRGRVLKRSAGEALQIVGTTKDITQQRK
AEQSFHLMASAFASSREPMLVLSPDLIITECNDAFIQLIGVSVKEQCGLNFNQIFIEKVDK-------AQLVLDKQVRFESKIKNQSGEIKVVDISVALF
ETYQQTSSYLIATMRDISDRKRNEDKLRQLALHDELTGLSNRNSLRESISEL----AGSKQPFCLVFIDLDGFKAINDNAGHERGDVELQRIGALLTAMF
GATGKVGRWGGDEFIAVAPNQNIEVTERSQELISHIEEDAIVVKGTELRLSASIGIAEFPEHSDNIESLVQCADAAMYRAKELGKGQTFVYQPGLYESMT
QQVSMLNDLRKAVENHLLDFYIQGKYD-LNGELKGGEVLCRWISGLHGVVSPAVFIPIAEEQNLDSAIGLQALEAACDYISIMESQQGDAIPLSVNISAN
QMLDPQFPDQAVSVCMDNNVSPEFIELELTESVFIRDEKSALRALNTLRELGFKLSLDDFGSGFSSLSYLRSFQFEVVKVDKSLIQGIHQDSKANALFNG
LITMLKSLQIDVVAEGVELESYLPFMEQADIKLMQGFYFDKPMPYDQFLARH--------
>tr|F2G6H7|F2G6H7_ALTMD Histidine kinase OS=Alteromonas macleodii (strain DSM 17117 / Deep ecotype) GN=MADE_1002490 PE=4 SV=1
--------------------------------------------------------------------------QSQNAQKDLELALWASQESFWSWKAQ
CDRMEIRS-F-SLHSESVSTWSGTLIQLL-ERVHEDDIEGQFHWSM-ALHGKDRIEFS-FRLKLDEDFQWVRLRGRVLERNAGEALHIVGTTKDITQQRK
AEQSFHLMASAFASSREPMLVLSPDLVITECNDAFIQLIGAMVKDQWGLDFNHIFIEKVDK-------AQLASDKQVRFESKIKTQSGEIRVVDISVALF
ETYQQT-SYLIATMRDISDRKRNEARLRQLALHDELTGLSNRNFLRESITGL----VESKKPFVLVFIDLDGFKAINDNAGHERGDIELQRVGAQLTAMF
GPIGEVGRWGGDEFIAVLPSQTCKIAEKSQQLIHHIEEDVISVKSSELRLSASIGIADFPAHSDSIEGLIQCADAAMYRAKELGKGQAFIYEPGLYESMT
QQVSMVNDLRRTVENHLLDFYIQGKYD-LNGELKGGEVLCRWISGLHGVVSPAVFIPIAEEQKLDSAIGLQALEAACDYISIMESQQGESIPLSVNISAN
QMLDPNFPQQALKICMNNSVSPEYIELELTESVFIRDEKAALRALNTLKENGFRLSLDDFGSGFSSLSYLRSFQFEVVKVDKSLIQGIHLDSKANALFNG
LIAMLKSLQIEVVAEGVELESYLPFMQQADIQLMQGFYFDKPMPYDQFLARH--------
>tr|B1Y236|B1Y236_LEPCP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) GN=L
--------------------------------------------------------------------------QRHDSEHRLRLALAGSRKGVWNWDAD
SDLVRIDS-F-EFDDKPLPM-TCSSSGLA-ELVHADDVDARMAWRL-HMSGAPDLDMS-FRLCLGEHVRWVRVRGSALERGKGLARRMTGTIKDVTSQRH
AEQSLRLMAHAFSSTRDALVVTDHDWRIVEANEAYCRLAGAAPNAVQGTVLTERLNPALAP-------LPIGDEAAWAEVTEMRRLDGLRVPVDVTITTL
PGDHSGGTY-LVSLNDISEQRRVEARLEHLALSDAVTGLPNRSALENQLLRQ----LDREQAFALMYLDVEGVKEVNDSFGHDAGDDLLRQLADRLRTIL
PAGTFISRWGGDEFVLVLAPGSGTEVRSCAQTMIAALSPPMKVFLNEISVAPSIGAVLVPRDGRESGLLLRKADSAMQAAKLRGRDSLAFYDGSLDTDSQ
RRVRMHNQLRLDAERNGFTFVAQPKVD-REGHAVGAELLMRWPTAAFGMVSPGEFIPMAEKIGLIGLMGRHALHAAAQLA-ARSLQVHQPLPVAVNLSPK
QLLQRGLDRQLLLACERAGVAPAMLELELTESALVDNMTIIEPLLQRLRQHGFSLALDDFGTGFSSLSYLRHLPFNKIKIDRSFVMDIDHDHRAARLLAH
MVKLCGALGMSTVAEGVESESQFKALLDLGVQEFQGYYFARPLPVDEWVARL--------
>tr|F5SY30|F5SY30_9GAMM Putative signal transduction protein containing a membrane domain, an EAL and a GGDEF domain containing protein OS=Methylophaga
--------------------------------------------------------------------------NMNEAEERLRYALNASGDGVWDWDVP
SSKVWYSK-QLTMLGYADGEFSNSLDEWS-SRVHPDDLALMEDLQR-YLDGKDCYINEHRIRCKNGHYKWIRDSGLVITREHGKPIRLVGTHADITTRKE
ADEKLKLANTVFTHAYEGILVTDTDNKIIEVNDAFTRITGYSREDVIGKSPKLLQSGKHSPTFYEEMWHSIKTEGYWSGEVSNRHKNGQPFIEMLTISEI
RDADGNAVNYVALFSDITHIRAQQIALERLASYDPLTSLPNRILLADRLKQSMAHCQRHQQLLAVAFIDLDGFKQVNDTYGHEVGDKLLVTISNRMKAAL
REGDTLARIGGDEFIAVLTELNVEDCESVIERLLTASSEPISIDDKTFSVSASIGVTLFPEDSVDADILMRHADHAMYTAKQLGKNRYHLFDVNQDDAIR
SHRKQLLHIERALENDEFVMHFQPIVNMRTGSVIGLEALLRWQSPEEGLLPPGAFLPYIENNPISVNLGEWVIHAVLKQISLWQAEQTMPDMISINISAL
QIEQTNFADRLASLLAYPEVDPHKIELEILETSALEDIQNVSNTMNACAQLGVKFAIDDFGTGYSSLTYLKHLPAEIIKIDQSFVRDMLIDEDDLAIVKG
VIGLANAFQRGVIAEGVESAEHGKALLELGCELAQGFGIAKPMPAELWIAGW--------
>tr|B7KEH4|B7KEH4_CYAP7 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cyanothece sp. (strain PCC 7424) GN=PCC7424_4938 PE=4 SV=1
--------------------------------------------------------------------RKHTELALRESEERLSTIISTNPNGLLILDRE
GKVLFVNPAAEILFGRPKKDLMGQI---L-GL--P-------------IIVNNYS--EIEILQPTGKMVIARIRQVKILW--EEKEAFLASLVDVTDLKG
AQKQLKILKQATEQSPVSVIITDAEGHIEYVNRKFEKLTGYTRQEVIGKNPRLLKSGKISQDQYKQLWRTLTSGQEWHGEFHNQKKNGELFWESASISPI
KNEEGVITHFIAIKEDITRRKAQDRILAYQANYDALTGLPNRFLAIDRLKLAILQAERQEQRVAVMFIDLDRFKNVNDTLGHEYGDLLLKQVAERLKKCL
RKSDTVARLGGDEFLIIIPNLKQSHCKGIAKKILSSLEKPFNLLEEEAFISASIGITLYPDDGDDVNALMRNADTAMYLGKRGGRNDFKFYTLGMNETNR
TRIIIENLLHQALKKKEIYLVYQPIMELKTEKVIGAEALLRWNNPQLGQVSPDQFIPIAEETGLINQLGAWVISQACQEVVQWKAQGTP-ISVAVNLSPR
QFRDSKLLKIITDAIAVNGITNHDLELEITEKLLLEDSPGSQGILSQLHQMNFPLSIDDFGTGYSALSYLIKFPFNRLKIDRSFITDMTHSQKAMGLVKT
IIAMSHGLNLQVIAEGVETSEQLNSLKSQGCDYAQGYFFSRPLTGEEFRYYLQLNKNP--
>tr|D4ZQA1|D4ZQA1_ARTPN Two-component response regulator OS=Arthrospira platensis (strain NIES-39 / IAM M-135) GN=NIES39_Q02220 PE=4 SV=1
--------------------------------------------------------------------SITAEAALRESEARLRTIISTSTNGLVVVDCQ
GRALFINPAAEALFGRQARELEGEM---I-GI--P-------------LVTKEST--ELEIFRHDGKLKIVRMRVVEISW--EQETAYLASLTDITDFKK
TEDQLKMFSRACDQSPVSIVITDSEGDIQYVNPKFEEITGYKAAEVMGQNPRILKSGYTTEPEYDVLWKQITSGKQWSGEFHNKRKNGELFWEHASICPM
RDEEGYITHFIAVKEDITQQKHNEEILAHQANYDALTDLPNRTLVFERLRQAIIQAQVNHSNVAVMFIDLDHFKNINDTLGHELGDFLLKEAGMRLKGCL
RTTDTVGRLGGDEFLVIIPNLDDIQAEYIATQVLGVLGEPFNLCGEEAFISASIGIASYPQDGNNASTLVRNADTGMYAAKQEGRNVFAFFTQNMNDEAQ
SRIIIENHLRHAINRDELSVVYQPFIHLATAQIVGAEALMRWYNPELGNIRPDQFIAIAEESRLIVDLGEWILSQACQEVATWHQQGNG-LWVAVNMSPR
QLRTPNLVNVIIEAIANNGLSSDCLELEITERSLVAEVPGVQSLIKQLHSLKIRLAIDDFGTGYSSLSYLKRFPFSVLKIDKSFISDLPDDQDAIALVKT
MITMAHGLGLVVVAEGIETSAQLDFLCNQGCDYGQGYLFSKPLPPAEFRAYLQKNS----
>tr|K9YJC2|K9YJC2_CYASC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cyanobacterium stanieri (strain ATCC 29140 / PCC 7202) GN=Cyast
--------------------------------------------------------------------------TLIHTQQKLGAIANYNINGLMVTDEE
GKVLFLNPACKKIFAGKANQMFGEL---F-GI--P-------------LASQKST--EIIIPYKEGKILTVKMDVTPIKW--ENQKAYLITFIDITKRKE
IEEQFKFLHQASEQSPASIMITDNTGKIQYVNSKFETITGYTREEVIGQNPRILKSGETTKEEYQKLWETISHGKEWHGEFHNRKKNGELFWEIASISPI
KDEYGFISHYVAVKEDITEKKRQEELLSHQANYDYLTELPNRLLGMERLKQEIAKANRNNLSVALIFLDLDNFKNINDTLGHQYGDELLIVVAQRLQECL
RKSDTVARLGGDEFLIIISSLSSSQGEIIASKLLYAMRNSFTIAGEERFISASIGITFYPQDGDNIQNLIQNADLAMYAAKRKGKNNFKFFNSRMNEVAQ
KKMQQETYLRQALKNDELFLVYQPIIDLKTKKIVGVESLMRWHNSILGNVSTIEFISIAEETGLITDLGKWLLESVCQQLADWQQQGIY-IYASINLSPR
QFRDVNLVDIILEMTEKYHIKPHYLKLEITEQLLVEDIPSVQGLLFNLSHLGFELYLDDFGTGYSSLSYLRKYPFKVVKIDRSFVLDMEESDKGKALIKT
MIAMAYNLNLSVIAEGIETINQLKFLEAENCCAGQGYLFSRPLLADNLLDFIADNF----
>tr|W6KB35|W6KB35_9PROT Chromosome, complete genome OS=Magnetospira sp. QH-2 GN=MGMAQ_2319 PE=4 SV=1
-----------------------------------------------------------------------ATMELRKVSALQSAILESATYAIVTMDPL
GTIMSFNPTAERMFGYRAPDMIGKRS--VLVLHRHEDLVKSETLSREVADRGRVDETECHLVRRGGGTFPARLTITRLGDRDDLVEGYMAVSSDITQRKE
TEEKLQLAHEIIQKAGEAVVITNPSGQIIDINPAYEKVTGYHRKDILGRNPSMAKSGRHDAAFYADMWTTLNATGRWEGEIWDRRASGEIFPKWLGINAI
RDDDGHVSNYVGIFTDISAQKSTERKLERLAFFDPLTKLPNRALFRDRLTQGLEMARRDTHPLALMFIDLDRFKNINDNLGHDVGDEVLIAVAQRIKGCL
RKSDTVARLGGDEFTVILRDPGDVDLGTLADDIIGVLTKPFHIREQDLFIGASIGIALFPEDGADDETLMKNADVAMYQAKQAGRGTYRFFTNEMNDNTG
RRIALEADLRTAIDQDQLALHYQPKIALENNRIIGFEALVRWNHPTKGMISPIEFIPLAEETGLIVPLGEWVLKTACTRIKNWRTKLNEDLTIAVNLSAR
QFEDPLLTEKIEGILTELHLPSSALELEITESIAMADVERTIAVIDGLKSRGLRISIDDFGTGYSSLSYLKRFPLHSLKIDKSFIHGLAIASDDEAIVTA
ILSMAHSMNLNVIAEGVETEDQLSFLRTNDCEEVQGYFISKPIPAEDVEKML--------
>tr|C1D6C2|C1D6C2_LARHH Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Laribacter hongkongensis (stra
--------------------------------------------------------------IDQ---LVRAESLARDGERSIKEALARAQIGYVDLDLA
RDRAVGNSVMAEMMGYPDDGAVLSPIDWI-GRVHPDDRD-MVRLRYRNLMAGDGLEFRLEHDRD---WRWVMATLVPIETPDGRALRVLGVYVDVTRLHL
ATAELRLAAHVQEHTPDAVLICDAAGRLLKANRAMQRLTGWAPEVLVEELLADLRS---------DAYPVPPANRSWEGECHYRTLSGVPLACWQRQSPV
LDEYGNLSYLLVTLSELSERQRQEARIRYLAEHDSLTGLYNRAALIERLGDVLAQARRQPHVGAVMYLDLDRFKQINDTLGHEAGDALLIEVARRIRSVV
RTGDAVGRMGGDEFVVLLARLEYRDAAAVADKLLAALLEPFVLSGQRVESPASIGVAMFPQDGEDADTLLRHADAAMYDVKTQGRGRWQFFTSALQSQVA
NRRAREAMLTRALERREFVLEYQLIYGNPVREPLAMEALLRWHTPAGERLPAQAFIDLAEDMRLALRLTRYTLDLVGQQLAGWLEAGLVPVPVAINLTSR
QFHDPLLVTHVAETLREHRLDGQWIEFEVAESALFADLEQSRKQLARLAELGVGVAVDRFGGDIRRWFELADAPLTRIKVECSVLAELSGNDRGRMAL--
-SAWQGVLGRPLAVTGVESDDDLACAERIGSQAVQGWVCQAPLNGEQMAQVLRQ------
>tr|U1ABB0|U1ABB0_9NEIS Diguanylate cyclase OS=Pseudogulbenkiania ferrooxidans EGD-HP2 GN=O166_14995 PE=4 SV=1
--------------------------------------------------------------ITQ---SRREQKAKREAEDRYLALVEQSLVGIYIM-QD
EKLAYVNPKLAEIMGYQPEEMAGMTMILV-----PGE---AERLRQQLLRRFAVMHYATRGLRK---DGVLVDMEVHSRLELNGRKAVIGVVMDISERLL
ADTNLRLAAKVFENSAEGILILDAGARIIAVNDAFSRITGYAEEEALGKASRIARA---------AMQQALADCGHWQGEMLDRRRGGQWYPAELSISAL
RDEDGVLCNYVAVFSDITQRKEAEERLQFLANHDPLTRLPNRSSLTASLDEALTRMDGEDGRLAVMFIDLDRFKLINDSFGHQVGDQLLCEIAIRLSRVV
GERGLLARLGGDEFTLLMSGFDSHQLADMASAILAALGKPLCLEAHEVFITGSIGISVFPHDGRDARTLLKNADVAMYRAKEAGKNTYQFFDVGMNTQTF
ERLLLENGLRMALERHEFELHYQPQLIAGSRALAGAEALLRWRHPQLGLVPPARFIALAEETGLIKPIGDWVLREACRQLAAWDALGLRVPRLAVNLSPR
QFGQPSLPAKVAGALQAAGLVAGRLELEITESMIMQSPTEAVSLLSELKSLGVWLSIDDFGTGYSSLSHLKRFPLDTLKIDQSFVEGLPDDDDNAAIAEA
ILAMAKKLKFQVVAEGVENEAQAVFLEGKGCHVLQGYHFGRPLPADEFAKLAAR------
>tr|A0A0C1CF29|A0A0C1CF29_9NEIS Diguanylate cyclase OS=Chromobacterium piscinae GN=QR66_00970 PE=4 SV=1
--------------------------------------------------------------ITQ---SKREQRAKREAEERYLALVEQSLVGIYIM-QD
ERLVYANPKLAEIMGHAPEDMVGMTMLLV-----PGE---AVRLRQQLLRRFAVMHYSTRGLRK---DGVVVDMEVHSRLELDGRKAVIGVVMDISDRLL
ADTNLRLAAKVFENSAEGILILDANARIIAVNDAFTRITGYAEKEALGKPSRIERE---------AMREALAGSGHWQGEMQDRRKNGEWYPAELSISAL
RDEDDELCNYVAVFSDITQRKEAEARLQFLANHDPLTRLPNRSSLTAQLDEALARMASQGGQLAVMFIDLDRFKLINDSFGHQAGDLLLCEIALRLARVV
GERGMLARLGGDEFTLLMSGFDSTELGDVAADILTELGRPLSLEAHEVFITGSIGISVFPHDGEDAQTLLKNADVAMYRAKDSGKNTYQFFDAGMNTQTF
ERLLLENGLRMALERGEFELHYQPQLAADSRALQGAEVLLRWRHPQLGLVPPVRFIALAEETGLIKPIGDWVLAEACRQLAAWDRQGLAVPRLAVNLSPR
QFGQPSLPAKVAGALQTAGLPASRLELEITESMLMQNPGEAVQLLAQLKALGVWLSIDDFGTGYSSLSYLKRFPLDTLKIDQSFVDGLPDDGDNAAIAEA
ILAMAKKLKFHVVAEGVENEAQAAFLQGKGCHTLQGYHFSRPLPAAEFAALVAR------
>tr|F9ZXT5|F9ZXT5_METMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylomonas methanica (strain MC09) GN=Metme_0062 PE=4
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------------VRISPEYSTSGEVRGLLVLGFDMTKLRR
EQLLDVERRHVFERMAQGIALYDQTGSRLIHDVAPSISVPCPAH-QQAVTVDEVGNGCAVSFCEPLIMKDMRLATVSEHCRSFALTSG-MV--SSWSDPI
IGSSGQQLGVVTLYRSQIERKRIEEQMQHQASYDILTGLPNRRMFRDRLNEEIGKAKRCGESLALLFIDLDRFKEVNDSLGHEIGDLLLVETAQRIRARI
RETDTVARLGGDEFIVILPRVDDSHLGRIAQNIVDDMNKPFSLDIHTVYVSTSIGIAAYPFDTVNADGLIGCADQAMYAVKEHGRNGFGFFTPAMQQQAQ
TRLLLANDLRDALVKGQLQVHYQPIVDVASGEIVKAEALLRWLHPQRGWVPPDQFISIAEENGLIHDIGDWVFRQAVGTARLWNADARVARQISVNLSPR
QFIKGDFYASWLAYLEQSGVAPEHIVIEITEGLLLDDRPDILQTINRLGNLGMQVALDDFGTGYSAMGYLKKFPIDYLKIDRSFVRDLESDSNDRAIAEA
IVVMAHKLGLKTIAEGVETVGQRDLLASVGCEFVQGYLYAKPMPERELLAFALE------
>tr|G3IVE1|G3IVE1_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylobacter tundripalud
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------------MKIVPECDADGKIDSVLALGFDLSDRRQ
QQVVEANRQRVFEKMAHGVALYDEEQKHLQTVAAPSFPASYKAK-LNPQMLDEESGNCHASALERIIVADMTKHPCWSLCQSFIREIG-AV--ACWSEPI
FSSSNQLLGVVTLYLNQIERKRIEQQMYRQASYDQLTGLPNRRLFGNRLREEIVKAERGAYSLAVLFIDLDRFKEVNDTLGHDAGDDLLVEAAQRIRLCV
RESDTVARLGGDEFVVILPKVDEVPQDRVAQCIVDAMVRPFLLGEQNAYVSASIGIAGYPQDADNAEVLIGCADQAMYVAKSMGRNCFSFFTHGMLEQAR
HRLELVNDLRGALDAGQLEVYYQPIIEVVSGKAVKAEALLRWHHPELGMVPPDRFIPIAEETDLIQEIGAWVFREAADTAKRWHGLSDGVGQISVNMSPR
QFTKDSGVQTFIDYLQEAAIDPSYLVVEITEGLLLDDCSAVTEKLELLRAAGIQLSLDDFGTGYSAMAYLKKFNIDYLKIDRSFVRDLETDPGDRAIAEA
IVVMAHRLGLKVIAEGVETEGQRALLMAVGCEYVQGYLYAKPMPVEAFLAYVAG------
>tr|Y0KHU5|Y0KHU5_9PROT PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Methylophilaceae bacterium 11 GN=Meth11DRAFT_1527 PE=
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------------YK--SPVIVEDKVVGTVGFARDISNRRR
ISNYEQFRSRMLELVVREIVAGAENGKQLTVVSALSLPEGFVDA-LEGMKIGMG---MGTAAFKRVIVEDVMTHPYWTKNREIAQKYG-IG--SSWAEPI
IGAKGNVLGAFGIYHHELERSESISKIAHLAYYDDVTGLPNRRFLFEQLKRSMAMNLESGANSALMYLDLDQFKTVNDSRGHDIGDMLLVEVANRLRANL
QAADTIARVGGDEFVVLVENLSSKQVEIVADRILKVLNKPFTIAKQKHHSSASVGITLFGQQKMDAEDVLQQSDIAMFQAKKAGRNTFRFFDPKMQANIT
ALVGLETELRKAINECQLKLYYQVQVDH-LGQPFGAEALIRWLHPERGMISPAEFIPLAEESGLIIPIGTWVLDTACAQIKAWQADPRE-LTLSVNISAK
QFRQVDFVQQVKASIQKHGIDAMHLRLELTESMLLENVEETVEYMNALGQVGVQFSLDDFGTGYSSLQYLKRLPLYQLKIDQSFVRDIVTDSHDRTIVRT
IIAMAQSMYIGVIAEGVETHEQRELLLTNGCRRYQGYFFGKPLPIEQFNAILKL------
>tr|H8YZ86|H8YZ86_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiorhodovibrio sp. 970 GN=Thi970DRAFT_02254 PE=4 SV=
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------------WRNSPLRDADGRIIGTLSSGLDVTERRQ
VGAELAQERTFLQHVIDGIMVIGEDYRLIRVNSAAAR----RA---EARGLSLADLSCHYGPCRESVLKDHKPAKVVHLDDSEEPDQQ-SY--EISASPL
LDEHGQVVGIIEIARDIAELRRSELSVLRLSQYDLLTSLPNRLLFADRLSAGIAEARRRGASLAVMIVDLDRFKHINDSFDHHDGDEVLKSVAARLQQLV
GEHETLARLGGDEFGIIPVPFHHREPSGFAERIHEALQPPFMLHGQRVLVGASIGIAVYPAQGNTADDLLRKADAALYSAKADGGKTSRFFTEELTADAR
DRLLLEANLQEALEQEQFELHYQPQIDLRAGGLSGIEALVRWRHPEQGLIAPGRFIPLAEESGLINPLGDWVLRTACEQMRVWREAGAPEVMMSVNLSAR
QFEQEELAEKVLSILEQSGLAPAALEIEITESTVMQSPRRSIDCLRQLRQAGVKIAVDDFGTGYSSMSYLKRLPLTKLKIDRSFVSDIPEDTNDVAIVRA
IIALGTSLSLELLAEGIETEQQQNFLLKEGCKLGQGYLFAKPLPAAEFVRFANE------
>tr|H0PTJ7|H0PTJ7_9RHOO Uncharacterized protein OS=Azoarcus sp. KH32C GN=AZKH_1849 PE=4 SV=1
----------------------------------------------------------------------------------------------GLLDRE
GRTIEINRAALEGAGLRLEDIQGKP-FWESARDAVRRAG-LGEIV-----RGQVENYG---RAGGKETLTLDFSLTPIRGADGEVAFLLAEGRDISDMKA
ARDALRESEAVYENLAAGVALIERNGRILAANPALQAILGYSEEELRALAPAIVAEEERDE-VRRQIEQLVSGTPSYRAQRQYFCKDGRSIWANVTVSPL
PGSEPSAPALVAIIEDITERKSAEDRIRHLAFFDALTDLPNRVQLEANLDEAIEAASPQNRALALLMLALERFKDINYTLGKSIGDRLLQEFGPRCRRLL
GDDAVLAHFGGRHFGVLVPGAGVEEAREVALRVLKDLERPFEINGFTLEIGAHIGIAVFPGHGTDAATLTRHTEVALRHAQRSSRSHA-LYTPGDDSYNP
RRLQLMGELRSAIADNQLALYCQPKLELATRRIVGTEMLVRWRHPSYGLISPDEFVPFVESTGLIAPLSKWVVDATLVQCLAWERAGVR-LHASVNLSTR
NLEDPHIAEQIGNALTTWGAVSGWIGVEVTESAVMAEPQVALLTLQRLKDMGITVFLDDYGTGYSSLAYLQKLPVDAIKIDKSFVQPMLEDADAALIVQS
TVDLGHKLGLRVIAEGVENEAICERLQAIGCDEAQGYFVAAPMPAGELMTWVEAG-----
>tr|L8MBJ4|L8MBJ4_PSEPS Diguanylate cyclase/phosphodiesterase OS=Pseudomonas pseudoalcaligenes KF707 GN=ppKF707_4712 PE=4 SV=1
----------------------------------------------------------------------------------------------TFLDKE
REWSGGTLG----------VASGEG-PRA--LVHVEDAS-SNALL-----Q----HCA---LVAD-SPRIRLFAGVPLTVAERDVTGVL----------S
VADGLRESQTLVSNLP-GVAYRSLNDRLEVVSEGCLKLIGYSAAELIEGRMDIIHPDDIPP-LRRKVSRALRTTP-YQSTYRIRTATGQTKWVWDKGCGV
YSADGKVLALEGFITDITEQKHAEECIRRMAYFDELTGLPNRLSMRDALGVAIATSGDSHAPVALLHVEVDNFREINETLGYREGDRLLQEIATRLREAV
DARETVARIAESSFSVLLPGMDASQAVQAARKVLEAMSTPFGLDDLYVPAECSIGITLYPGHGTDPDSLLRRANIARYGARHRAEKLA-VFAGALDSDNA
QRLTLMNDLRRAIDSDELLLMFQPKLRMHARQVSGVEALVRWKHPERGLLGPDQFIGFAENAGLITRLTYWVLAAAVRESHAWHGAGHA-VPIAINLSSH
DIRDRQLFEQISRALETWGGAPDWIQFELTESCIMEDLSIARQVLTQLREAGFKLFIDDFGTGYSSLAYLRHLPVDYIKIDQSFVKDLDSDRESAAIVEA
IIKLAHSLGIAVVAEGVESVSTMEMLSNWGCEEAQGYCISKPISGRDFQSWNKAF-----
>tr|U2A1A2|U2A1A2_9PSED Uncharacterized protein OS=Pseudomonas sp. EGD-AK9 GN=N878_00695 PE=4 SV=1
----------------------------------------------------------------------------------------------TFPDQG
GDWCGALRG----------MADGEN-AWE--RIQVADAS-THERL-----R----HCE---LVAG-PPFIKCFAGVPIALAGGEMVGVL----------A
VADGLRESQTLIGNLP-GVAYRCRSDRLELVSEGCLQLTGYAADDLITGKMDIIHPGDLPT-LRRGVTRALKKQP-YQSSYRIRTPDGQTKWVWDKGCGV
YSADGKVLALEGFITDISELKCAEERIWRMAYFDELTGLPNRLSMHEALSTAIAHSGDSHAPLALLHVEVDNFREINETLGYREGDQLLQALASRLRERG
EPLETLARIAESSFALLLPGQDASHAMQVARDVAQTLHAPLALGELLVHTDCSIGITLFPGHGSDPDALLRRANVARYGAKQGTERVA-IYAGSLDSDNA
QRLALMTDLRRAIERDELRLLFQPKLRMGSKRVSGVEALVRWEHPERGLISPSQFITCAESAGLITKLTYWVLAAAVRESYLWHDAGRA-VPIAINLSPH
DIRDPQLNEQIARALQTWGGTPDWIQFELTESCIMEDLAAARQVLTRLREAGFKIFIDDFGTGYSSLSYLRKLPVDYIKIDQSFVIGLGSDKESAAIVKS
IIELAHCLGIEVVAEGVESTEAMDMLSGWGCEEAQGYCISKPISGHDFQSWSRAF-----
>tr|F3KQ85|F3KQ85_9BURK Sensory box/GGDEF family protein OS=Hylemonella gracilis ATCC 19624 GN=HGR_02997 PE=4 SV=1
----------------------------------------------------------------------------------------------HLP-EL
--------------QD---FLGGRG-YA-----AVVDPQ-WRQIV-----R--------------------------QPSLSAHPDRTA-----------
---ALRFEKTIVRSAPLAIYTRDTEGRVTAWNPAAEKLFGWTEAEVLGRPSTEYQDEDKAL-RLRVIAGES----IPDIEVQRQKVTGEMFDLSASLSPL
RDDDGTISGFLTIAADVTARKQVERQVEFLAYRDVLTGLPNRSLLQDRFAQAIARAERHHRKVALLFLDLDHFKTINDSLGHATGDALLKEVARRLSDGM
RESDTISRQGGDEFLVVLSDLEGTE-TPVLLKIRERLQQPLLFDGHELSISSSIGVALYPDDGLDFETLLKKADTALYRAKDAGRNQARFFDEQMNTEAV
DHLRLKNGLHRALSRGELELHYQPQFDLRTGAVIGVEALLRWRHPEEGLISPARFVPVAEDSGLIVPIGEWVIRQACAQAMAWRQAG-P-LLMAVNLSAV
QFRRGDVQTIVAQALRDTGLAPELLELELTESILLQNTERVLEGVDQIKQLGVKLSIDDFGTGYSSLAYLKRFAVDKLKIDQSFVHDLARDSDNAAIVRA
IIQMAAGLGLRTIAEGVEDAEVLAVLRRFGCDEAQGYFLARPLPATEFAELVKRF-----
>tr|W9VJU8|W9VJU8_9GAMM Diguanylate cyclase OS=Thiorhodococcus sp. AK35 GN=D779_0271 PE=4 SV=1
----------------------------------------------------------------------------------------------HAGRQL
GTWSYALRDTAASAVL---REGGQG-IA-----HPLDPD-LQHLE-----A-------------------EGFIGAPIPGLYGRPSGLISG---------
-CS-----------------WVRPDGSFYYMTPSAEHFTGFPSEHFLH--DRIVHPDDKAI-WKRHIKGSLPPQDIYELEFRIRHKDGRLLWVEHRCRPV
IDASGDYRGRRVSISDITARKEAEEQIRSLAYFDPLTGLPNRRLLLDRLGHALAASRRTRQYGALLMIDLDHFKSLNDTQGHDVGDRLLVEVARRMTQSL
RAEDTVARLGGDEYLVMLETLGTDEAEGIAEKIRLRLKEPYPIGQADHYCSCSIGLSLFQGDRESVEVLLKQADVALYQAKDAGRDTIRFFNPEMQKAIE
SRIALETALRQALLRGELQLFYQPQIDQ-HGKRIGAEALLRWLHPNRGLIPPLDFIPLAEETGLIVPIGHWVVDTACAQLKEWETCATS-LQLAVNVSAR
QFHQPDFVAQVRESLERSKANPARLKLELTESVVLENADSVIERMHQLRALGVSFSMDDFGTGYSSLSYLKRLPLDQLKIDKSFVRDITTDPNDAAIVRA
ILAMSRSLGIQVIAEGVETEEQQLFLLDNGCFAFQGYLFGKPSPIVDWRSQATQG-----
>tr|Q47Z22|Q47Z22_COLP3 Sensory box/GGDEF/GAF/EAL domain protein OS=Colwellia psychrerythraea (strain 34H / ATCC BAA-681) GN=CPS_3258 PE=4 SV=1
---------------------------------------------------------------------IQANLALKASDEQMQLVLAGADLGFWDWNIV
TGRVDRNERWATMLGYTHKELKHSTNQWA-DFVHQEDREKWQSI--NDVLEGKSHSLEYRMLTKEGGYRWVHDQANVMQRSNGKPLRMSGTHSDITNRKL
AEEKIKLAASVFSHAGEGIIITDDKATIIDINDAFTNITGFSREEAIGKNPRILQSGRQTPEFYADMWQALQNEGYWSGEVWNRRKNGEVYAVMQTISAV
RDVHGIATHYVSLGNDITLMKEHQNQLEHIAHFDILTNLPNRVLLADRLSQAMLQCSRHKQSLAVVFLDLDGFKHVNDTHGHDIGDELLIALSVRMKEAL
RENDSLARIGGDEFVAVLADLTTEDCEPVLERLLLAASEPVIFDNIVLNISASIGVTLYPQDNVGADLLMRHADQAMYVAKESGKNRYHLFDTAQDDAVK
QRESLE-AIRSALDNHQFVLHYQPKVNMRKGIVTGVEALIRWQHPKRGLLNPIEFLPVIENNPMSIEMGEWVIDTALTQISQWQKLGLNPVSISVNIAAL
QLQQPDFTDRLMILLAAHDVEPHYLELEVLETSALEDVYNVSTIMNACMALGVNFALDDFGTGYSSLTYLRRLPANLIKIDQSFVRDMLHDSDDLAIVEG
VIALAKSFKRDVIAEGVETIEHGTALLQLGCELAQGYGIARPMPASEIPTWISD------
>tr|H8GNU1|H8GNU1_METAL PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Methylomicrobium album BG8 GN=Metal_3173 PE=4 SV=1
-----------------------------------------------------------------EEKRTQAEQALQESETRLMLAIKGSNDAPWDWDLE
KNRLYYSPQWWHMLGYETDELQSDAKLWH-SLVHPDDLDFIQNDLRKA--------------------------------LHRGQSMHAIEFRLRHKDG-
---------HYVPILERSFISRNKEG----------KLRGFMLE-----------------------CITSVRAGLKS------------WWSLLNVSVA
RDHSGNVTEYVGVFADITQLKASEAQLEFLAHHDTLTSLPNRLRLFFRLEHSIETTKREGTQLALLMLDLDRFKDVNDSFGHLVGDQLLQLVANRLVNRV
RDIDTVARLGGDEFTVVLENITHEDA-RIAQAVINDLSEPWSINAGEVLIGASVGISLYPQHGHTPELLLQQADAALYEAKEGGRNRFAFFSNEFTEAAR
RRIEMEARLRRALVQNELLVYYQPQIDIATGEIVGAEALARWQDPVEGMISPNHFIPVAEQTGLIQAVGAWVLKETCRQGKEWLDKGKP-ISLAVNVSQH
QIRQSDINVLVAEVLRETGFPARYLELELTESGLMERQTDVIEILKSLREQGVRLAIDDFGTGYSSLAYLKRFPLNVLKIDKNFIDDIPDQQDDMEIAST
IIAMGHILGFKVLAEGVETSAQLAFLKEKGCDLYQGFLVSHPLPAAEFGALLAS------
>tr|F9UB11|F9UB11_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiocapsa marina 5811 GN=
----------------------------LDYRIRRPDGEIRWLTSRRELTRDAQGRPV--RIDGVVQDQHLARQALAASEARYRTLFEHAAQPLVLIDGD
GLIAAANQAVYDLLGYPGGTLVGAS----PAALSPRLQPDVSAAKAECAERG-VQRFEWEHLRRDGSGVPVEVTLNPIEL-EGR-QVLLGTLYDLRDRLR
AEDWERRASTVFTATSEGILITDPEGRILAVNPAFTTITGYAEDEVRGRRPNLLQSGRQDQVFYRAMWHALIETGHWQGQLGNRRKNGELFTEWLSISAI
RNSAGHIQSYIGIFSDITKAQRYAEEIEHLTHHDLLTDLPNATLFRARLDQTMRTARADGRQVAVMAINLDGFKHVVSAYGHALADGVLVEAARALKGAL
PNDAMLARLGGDTFVIGIATPPGESVSEHVARIQSVLLRDIRVEVGNLNMGSGVGVALCPSDSCDAAEMIQFADSALNTAKAAGPGTCSFFRSEMTEVAG
QRLRLAQDLRCALAKGELVLYLQPKLDLSNGRPAGAEALIRWQTSEGQLRLPQEFMPLVESGDLLWPVGRRVIQEAARIIALWKADGVTPVPIAVNISSA
MIGSGQLADAIAGAARAYGIDPRLLEIEVLENVLINDPERARAEIAAVRALGVAVVLDDFGTGYSSLAYLKRFHFDSLKIDRSFINGLGQESDDTAIVRS
TISMAHHLGIRVVGEGVESADQLVQLSNLGCDLAQGFLLGRPMPPDDLTEMLRTGSLPI-
>tr|Q478L4|Q478L4_DECAR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dechloromonas aromatica (strain RCB) GN=Daro_3990 PE=4 SV=1
----------------------------TDNPIKQESQPVACLTLG---SRQASGVPLSEKLSGQFSQRLAAQEEARRLQENLSGLFDTLTDFIFILDQA
GRILHYNRAVAEDLGYGQNTLKGKT----IAAVHPENLRQVTVIISGC---------PLPILCASGEQIMVETRVVNGYW-DGQ-PALIGISQDISERLM
AEERQQLAASVFDNAHEGIMITDPKGNILEVNATFTELTGYSRAEALGNTPDMLKSGHHDPAFYEEMWQKIRDDGYWRGEIWNRKKSGEIFVEQLTISSV
RNRDGALSNFVAIFSDITLLKQHQQRLEHLAHFDALTQLPNRMLLSDRMQLAKAQAERSGKTLAVCYLDLDNFKPINDRYGHSVGDFLLIEVAQRLKTCV
RAGDTVARLGGDEFVLLITNLDDNECDHAMTRVISALSQPFRVSAQFVTVSASIGVTLYPHDGSDSDTLLRHADQSMYAAKQEGRNRYHLFDPENDRRAR
LRREEIGQIREGLANGEFKLYYQPKVNMREGSFIGAEALIRWQHPERGLLLPDSFLPALEGSELAIDIGDWVIQEALKQIDAWHRTQGIDLSVSINIAGI
HLQHPGFSRRLGELLAAPNVTPGQIELEVLETAALEDIQTTAELFAECRNLGVTFALDDFGTGYSSLTYFRRLPADMLKIDQSFIRNMLDDTDDLAIVEG
VIGLTHAFKRQVIAEGVETVEHGLVLLLLGCDMAQGFGIARPMPPEQLPDWIRHFQPDE-
>tr|A0A0A1PSU0|A0A0A1PSU0_9BACT Putative diguanylate cyclase YegE OS=bacterium YEK0313 GN=yegE_1 PE=4 SV=1
--------------------------------------------------------------------AKLAETELRRSELRWQFAVEGAGDGLWDYDIA
SGHIFYSHRWKAMLGYADHEIGPTR-NEWSDRVHPEDLPRCHAAIEAH-YRGPDFALEMRMRVKDGTWRWMYGRGKVIERPDGQPQRVVGTLADITARKQ
AEEAMLALNALFESIGDSVISTDAEARVTFMNPVAEAMTGWPAAEAVGKPLRVFATGEPLQPFYL-------NEGA-----VLLGRDGERRNVRDSAAPV
RTASGEVIGAVLVFQDVTRARTLQQALEHQANHDSLTGLPNRTAFERALGAAGEAALASGRPQVLCFIDLDRFKLVNDSAGHAAGDALLRDVAGVLRRIC
RAGDVAARLGGDEFGLLLGDCTPENGEKVAQALLRDLGIGFVWDERPYQVGASVGLTVIGPQVRRIDEWLSEADIACYTAKAAGRNQVAVYGDAGSHRNH
RQVQVAAGIRQAIEADRFCLFAQEVVSLSAAGGRHFEILLRMLDENGNIVEPSAFIPASERFDLMGNIDRWVIRTTLRAHGERLRA-AAGLSIAINLSAN
SLNDPFLWPYLQEELDASGLAPGRLHLEITETAVINNLTAARGFLGRARAAGCGVVLDDFGTGLSSFSYLRQFPVSSLKIDGGFIRQMADNEIDRAIVES
INAVGHRLGAETVAEQVEDEATLELARAMGIDRAQGFAIARPRPFESI------------
>tr|A0A0A1P9H0|A0A0A1P9H0_9BACT Putative diguanylate cyclase YegE OS=bacterium YEK0313 GN=yegE_2 PE=4 SV=1
--------------------------------------------------------------------MKAAEAALRRSELRWQFALDGSGDGIWDWNPG
SGEVFYSRRWKAMLGYEEHEIGSAV-SEWSDRVHPEDLPACWQAIAEH-FRGADFSIEHRMRAKDGSWRWIHDRGRVIERPDGKPSRVIGTHTDITSRKE
SESALLALNALFESIGDSVISTDAEARITFMNPVAEEMTGWSAAEAAGRPLGVFKSGEPLRPFHL-------NDGA-----VLLARDGERRSIRDSAAPV
RTAAGEVIGAVLVFQDVTKARSLQQALEHSANHDGLTGLPNRSAFERALREAGEAARRGGVEHVLCFIDLDRFKIVNDSAGHAAGDALLREVANLLRRLC
RPDDLPARLGGDEFALLLRGCTLAEGETIGQRFIDSVALRFTWDDRSYQIGASLGLTRIGAGATRPDELMTEADIACYTAKASGRNRMAVYGGAGSGRNH
REMQVAAGIRNAIETHRFRLFAQEVRSFDPNATRHFEVLLRMVDDSGNIAAPADFIPASERYDLMGNIDRWVIRSVFQNYGARLRA-AVGTTLAINLSAN
SLNDPFLWPFLQEQFAASGVPPALIDFEITETAVINNLSAAQQFLSKARAAGSGVILDDFGTGLSSFSYLRQFPVNGLKIDGGFIRQMHDSEIDRAIVES
INAIGHRLGAVTVAEQVEDVATLDLVRAMGIDRAQGFVIGHPKALDSV------------
>tr|D7DM80|D7DM80_METV0 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylotenera versatilis (strain 301) GN=M301_0405 PE=4
--------------------------------------------------------------------RHNLSEQITKGNERLDLALKGASLGLWDLDVP
TGKAFYNARWAEMLGYQLSEIEQSM-DAFVKLLHPDEKDEVLAAVEAH-FKGADFSLEFRMRHQDGSWIWVYDHGRVMERADGAPIRVLGTHMDISKRKA
TELLANSNA------------------LELITA--KKNHKWVR------------------------------------------AQGSA----------
IDENGKVVRLVGAFQDITQQKTAEDAIKQLAFYDVLTQLPNRRLLIDRLERALVSSARSESYGALVFIDLDNFKTLNDTLGHDMGDALLKHVALRLQSCL
RDCDTVARFGGDEFVVMLENL-DLEPEMVGAKIIHALNQSYEIVPDGHYSTPSLGATIFYGKNDTVDEALKRADIAMYQAKSAGRNCLRFFDPEIQANMD
TKASLVETLRYGIGNNQFVLHYQPQID-RA-VLTGAEALVRWNHPKQGLISPLEFIPLAEEMGLILPLGKWVLETGCKQLVSWAGSKTEHLNLSINVSAR
QFHQPNFVAQVLDVLSATNVNPQRLKLELTESMLVDDM-DVIAKMTLLQSAGIRFSLDDFGTGFSSLSYLKQLPLFQLKIDKSFVRDVLSDQNDAVIART
IVALASSLGLSVIAEGVEVEGQRDFLEGIGCYEYQGYLFSRPLSIEDF------------
>tr|B7KRQ5|B7KRQ5_METC4 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylobacterium extorquens (strain CM4 / NCIMB 13688) 
--------------------------------------------------------------------SKQATEAIRLQEERYRLAMLATQDAIWDHDIT
SDTITWSEGAHPLFGYSDAGIASTG-AWWRSKIHPDDRDRVTASLKEF-IDGSRWSEEYRFARADGSYAAVIDRGFVIR-AEAQAVRAVGAMRDITEQRR
ADSALRASE------------------FRYIHP--DGRLIWLA------------------------------------------SAVER----------
----VDADRLVGITFDITERKCAEEQAWRAANHDALTGLPNRRLFRQRLEQALTSAECGGASVSLLLLDLDHLRDVNDTLGHDAGDTVLMEVAQRLQDGL
RATDTVARLGGDEFALLLAEPMRMDQ---ARALIERLRQPFCHRGHMLSCKASIGLAAYPDHHHESHELMKDADIALYHAKAKGRNGVVVFAPEMRAETE
RRVQIASEVQTAVVAGHIVPFYQPKVCFST-AIVGFEALARWQHPERGLLTPGYFGSAFDDPELATAIGESILRQVACDLREWQERGLAPGRVAVNFSSA
EFRKADLAATILIVLDEYDVPANLFEVEVTETVFLGNGTNVPATLQQLQDAGVLITLDDFGTGFASLTHLKQFPVGHLKVDQSFVRNMEQDKGDAAIVAA
VVGLGRSLDMKVTAEGVETAGQAIRLREMGCDYAQGYRYSKPMASSRV------------
>tr|A9VWI8|A9VWI8_METEP Diguanylate cyclase OS=Methylobacterium extorquens (strain PA1) GN=Mext_0136 PE=4 SV=1
--------------------------------------------------------------------SRQASEAIRLQEERYRLAMLATQDAIWDWDLG
ADTAEWSDGAYRLFGYDDAERADTG-AWWKSKIHPDDRERVTTSIKHI-IESHRWSDEYRFARADGSYAEVTDCGFVIR-TEGQALRMVGALRDISEQRR
ANAALRASE------------------FRYLHP--AGPQIWLT------------------------------------------MRAER----------
----VEAGRIVGITFDITERKLSEEQAWRAANHDALTGLPNRRLFHQRLEQALAAAERGGTSVTLLLVDLDTLRDVNDIHGHDAGDAVLREVSSRLVEGL
RASDTVARLGGDEFALLLTEPLRLEH---AEVLLERLRQPLVYRGHRLTCTASIGLAAYPDHHRNPYDLLKDADIALYRAKAQGRNSAVVFAAEMRSQTE
RRVLIAAEVRTAVAAGQIVPYYQPKICFTT-AIVGFEALARWQHPEKGLLTPGYFGSAFENPELATAIGSSLIRQVAADLGQWCRCGLDPGRVAVNFSSA
EFRRPDLAGDILSVLSEHDVPPARFEVEVTETVFLGHGTVVPATLRRLHDNGILITLDDFGTGFASLTHLKQFPVGHIKVDQSFVRNVVQDQGDAAIITA
VIGLGRSLGMQVTAEGVETVVQANRLSAMGCDYAQGYLYGKPMAGSRV------------
>tr|F0SXS1|F0SXS1_SYNGF Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Syntrophobotulus glycolicus (strain DSM 8271 / FlGlyR) GN=Sgly_
---------------------------------------------------------------------------------------------------D
LTIVEISASFEKIAGYQREELLHKD---L-KELFPDSRSDWAEVLKNTVLHHQLLSFEYF---SNLNETYYSVII-----IPFTSKQRLVYFLDITQTKR
NESKITLSETLVNNLGDIIYTCNLRGMITMVNKMFCQLTGKTEKKILGTRITDYNPENTAIAWDRAIAE-LMLTGEPAHEYQYFLPDGSSRFYYATLSPI
SDLNKKIVGFIGSNHDITSLKINEQKMISLAYHDSLTKLPNKTLFLDRLRTAISIAERNKVKIGVAFVDLDNFKELNAVYGHDHGDKLLFEVAQKLVSCV
RSYDTVARFGEDKFLVLFQHLIHNELFTVFERIRLALFTPFSIGRHSISLTASIGIGIYPDDGVDANEIILNANTAMDKAKKMGKNCYYFYNDQFKEALN
RQNMLRTMLISAMNNQEFLLYYQPQYEIPTRRLRGFEALLRWNNPAFGLILPVEFIKIAEETKQIIPLGKWVIKNACEVCKMINDKYGLNLIVSVNISLV
QLQEKDFFDTIMETVKHSGIKPSNLELDIKENVIMENFDYMVSVLKKLKKAGIRIALDDFGLSNLSLSQLKRLPLDMVKLDKELLNYIEYPNSQGALTDS
IIDLIHHLDIEMLAEGVENKEQVDYLLKGNCDNIQGFFFAEPVAREKIEEIIEKG-----
>tr|F0SZN3|F0SZN3_SYNGF Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Syntrophobotulus glycolicus (strain DSM 8271 / FlGlyR) GN=Sgly_
---------------------------------------------------------------------------------------------------D
CEHLYLNTAYARIIGGKKKDVIGST---L-KELHSDPGS-LISFLGEIASRGNREVLEQY---ADLGDKWYKIRA-----FSPETGYFVAIFKELSEPFQ
SHEELNVQKEK-NKILELIMRS-------SCDRVWYLKRNTGEKELAGRFLNVCTENITIEEWEHRIHPDEFFNGKTEYEYRVRSEDGSYKWIRSSGRSY
SDQNGKPSILAGMHIDINNLKVHEDQLAYIAYHDSLTSLPNRKLFFDRLDITLKKAKRLNEKVAVLFLDIDNFKKINDSMGHDCGDEILRQSAHRISSNI
RDYDTLARLGGDEFVLSFQNASCEEILALTKRVKDCFLKPFVLGKNSVHLSCSIGISVFPDHGVTKEELLKYADMAMYKAKESGKNTVRIFSFAIAEEVL
LKFNMEKGLRKALEKEEFELIYQPQYDIETGRIRGVEALLRWNNPFKGHLEPVDFINVAEETGLIIPIGEWVIKKACETAKKWKSEYDFQGMISVNISAT
QLRNGDIVKAIKDILSETELSPSSLEIEISENTFADCLDETILKMIELKKMGIKISLDNFGKGYSSLGYLRRLPIHVLKIDKSFVEEINPGYQGKKIVSS
IISLAQDLDIDVIAEGIETSEQYDYLKKARCGFIQGHFTSKPISEELIGELIKRD-----
>tr|U2EMX4|U2EMX4_9FIRM Diguanylate cyclase domain protein (Fragment) OS=Clostridiales bacterium oral taxon 876 str. F0540 GN=HMPREF1982_00920 PE=4 SV=
---------------------------------------------------------------------------------------------------D
FRIIRVNNNFGKITGIDTKNISGKT---L-REILPDIEEYWIKELSNAALNGLRIQMEEY---CKPLKKYFRVNA-----FSMEKGRIYVLFTDVTKDKE
VEALSE-------NARDTILFVREDGKIIEANKAAVESYGYTYEELLTMNIS----DIRCSDFDCLIPTD----GI--LETIHKKKDGTT-F-YVEVSSK
GTLFNGEYIVVEMVRDITDRKQTEERLQRLAYYDPVTDLPNKKYFSEYILESLDKAKQNNEMIAVLFIDLDRYKKVNDTMGHLIGDKLLKGAADRFKALV
NESVFAARVGGDEFIIIQSHIKGDEAADLAYRILTSIKEPFYFDGEEIRITTSIGISLYPMHGEDALTLMKNADMSMYRVKNSGRNNYEFYIPGINKEAY
ESIVIENSLHHALENNEFILHYQPKFNALTGKIIGMEALIRWKNPKLGLVPPGKFIDLAEETGLIVPIGKWVLKNACEHNKLWQELGFPPMRVAVNLSLR
QFEDGNLVEIVKNILKETELDPKYLELEVTETMAMKNMDLIVKALRELKDMGIHIALDDFGTGYSSLKYLRNIPVDTLKIDRSFINDLNSNSSYVAIIDA
IIDIAKKLSLGIIAEGVETLEQSKFLVEKKCFEMQGFLFSKPVSKDEFENMLLKY-----
>tr|D6SUE5|D6SUE5_9DELT Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfonatronospira thiod
----------------------------------------------------------------------------------------------------
------NRSML-----RKFEILEAE---D-GY--QALELETDLVLLDLMMEGID--GIEV---CRRLKERPPVIF-----ISAVNDPKVGGMDFVDKPFD
RNELLSESETLFETKSAMLLVDTESGLLTMANKEFCDLIGYTRQEVENSLHFLNV------------HPDTSRQDATAEEIKGLTREKKLHL-YYKVAA-
---------LVISIFDLTDKRRVEEELRQRTFYNSLTGLPNSELFKNRLKKSIQTRQEQGYFFAVIFIDLDRFKLVNDSLGHQKGDELISLMAKRLERGV
KKRDTVAHFGGDDFGLLIEAEDLE-AALRAEKIKDQFVEPFEIAGNEIYTTCSMGIVVSSQDYSEPEEIFRDADTALHRAKSTGPGNYVVFDPQMHAQVS
DLLQLETELRKAIQQKEFVLYYQPIYNLADLRITGFEALIRWIHPEKGMVPPNVFIPIAEETELINPLGEWILDTACRQARKWNKG-GRELTMNINLSGV
QFKDKNLINVLENTFRKNSISPLHINLELTESVVMGDAEESINTLNKIKKLGARLSIDDFGTGYSSLNYLQKFPIDNLKIDRSFINTMETQS-GQELVRA
ILAMTQSLGIKAVAEGIETWEQVKLLQELNCNLGQGYHFSKPLDEESADALLQEH-----
>tr|A0A011QQW1|A0A011QQW1_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-92 GN=gmr_10 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------GVMGVQFLDDKDAT---L-RFRLACSARELLFSVSDATA------FAPY---ADHLRNFAML-------------------AVILEERQ
QRRTI-RERRYLDIAGVMLMALDEQGRILMVNKKGAELLGESESALIGMDWFDNL------------PAGRLMAGETR-----LER----------LTRL
RSEAGAPVGTLSSAEDVTERRQAEERIRELAFFDQLTSLPNRTLLLDRLKQGLVTCLRNASHGALLFIDLDHFKSLNDTLGHDTGDILLQQVARRLTHCV
REEDTVARLGGDEFVVILAGLNGAKAEAVAHKILSSLNDIYHLGNTVQRSTASVGVTLFDGKQVSAEELMKQADLAMYRSKDAGGNRISFFDPTLELAMK
ERVVLERDLRRALADGQFLLYYQAQVGS-NGRLCGAEALLRWQSPRRGLVLPGEFIRLSEETGLILPLGLWVFEAACRQLAVWASQEMARLTIAVNVSAR
QFHEHDIVDQLLQVIQRTGAKPERLKLELTESLLLDNVADAASKMSALKARGVCFSLDDFGTGYSSLSYLRRLPLDELKIDQSFVRHIVANSSDAVIART
IVALGQSLGLGVIAEGVESDEQRVFLASIGCVAYQGYLRSRPLPVDDFEQLVRRA-----
>tr|C8X1Q0|C8X1Q0_DESRD Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfohalobium retbaense
----------------------------------------------------------------------------------------------------
-----MRRSLSELLQSQKF----ST---N-KEAKNCLSEYFNIVLVDLNL------PDDS---GKNLIDYIHIIV-----VSGEANFENNVYDFIKKPFN
VTHLLKFSKFIIENSPDFIYLLDDSGFFTYVNRKAYELLNYHNGELLGLHYSSII------------YEGERRTGERAGEIRLKKFNETPHFIYTELFAD
SVRRQNFVGTYGVIRDLTERIRSEDLIRFHLYHDSLTSLPNRTLFNDRLHMALLHAKRNKKKFSLLFLDLDNFKKINDNLGHQSGDEVLQNVAKILKKSV
RESDTISRIGGDEFVILIENLDKSETDKICYKILNAFKEPMYCQDQEVRITASIGIAVYPEHGQTKEQLMRRADMAMYKIKSKTQNSFCYYSNKDNGSCY
KSIELENDLYMAIENNELAMFYQPQVDCENETIVGFEALMRWFHPKFGLVSPSVFIAIAEKNGLINELGRWGLQQTCKDALYFEEKCAEPMKFSFNISAK
QIHQSNFIDETLSIVNSFDLKENSIELEITESSVMHNLNAVSYFLMELRKSNISIAIDDFGSGFSSLSYLQNLFVDTLKLDRSFISNADLNKKKRTIFTA
IQSMAHSLNVDLVIEGVENFSQKQYLKDLGLSIIQGYYYSKPMSLEDLEKSLFLK-----
>tr|E1VPN6|E1VPN6_9GAMM Uncharacterized protein OS=gamma proteobacterium HdN1 GN=HDN1F_31950 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------NSVLGLAGATPF----KT---L-QELQQAIETPFDLVVVDSVA------FYSY---CKQLLEILAIIA-----LAPIAATEQGVSDILVKPVQ
QESVINQAEFFSINSPDIVYVLDSNGRITYINDNATTLLNQDRQQLIGQHFSTLT------------GDDERRGGDRKNEMQLKKRGKTLS-IPFEISAP
GTGKTRFIGTFGVARDISTRKQAESMIRFQVYHDQLTGLPNRTLFRDRCQSAISQARRQQKKVVAITLDLDRFKAINDAFGHTAGDQLLQNVSRRLQGCL
RESDTLARFGGDEFVILLPQTQTEESNVVAEKIRQALLTDFAVNHQAVSLTASIGVALFPDHGDSVDTLLRNADIAMNHAKTLGKNRFQYFEHQIQDSLS
RRLNLEFDMRAGIAESQFCLDYQPQIDAESGQMVSLEALLRWEHPRLGRLKPGDFLKIAEETGQIIALGEWVFAQVCADLARWKNPA---IRVSVNFSPS
HVEHPQFVPMIVETLRQHQISGQQIELEITETLLLRQQPEINEKLLMLSQQGIHIAIDDFGTGYSSLSYLHRFPVHTLKMDRSFIERVDAQGRETCIVKA
LVSMAEGLNLRLVAEGVETEQQYRHLRNAGCTMMQGFLFSEAVSGDVLEKLTQAS-----
>tr|C0N6D2|C0N6D2_9GAMM Putative uncharacterized protein OS=Methylophaga thiooxydans DMS010 GN=MDMS009_1784 PE=4 SV=1
------------------------------------------------------------------RELQRRSELLAKSEKKYRRLVENLQDFLYSHDVN
GIFNYVGPSVTLILGYSQEEFLQ-H---YLSFL-PETEVQLVPLFTEHTLAGYKSNYEVEILDKKGGLHTLAVTEVPSYNDNKEVIGVEGIARDITEFKA
SQQKLEKLSLAVEHSPNAIVVMDRAGEIEYVNPKFTSITGYHNDEKLGRWPDLINSGVNMPGIYDEIWQTIRRGDDWRGELQYRKKNGDLYWAQELIAPM
LNSEGHATHFVATQIDITEARRLSEETSYQATHDQLTGLINRHEFDLRLERVVLAAKHNLTEHALCFLDLDQFKLVNDTCGHIAGDELLRQIGSLLQSNV
RSRDTIARLGGDEFAVLMEHCSIDRAYKACEQILQLLDFRFHWQDYTFTVGGSIGLAIIDQHTRDSNEALKHVDTACYSAKDAGRNRVEVHREDSLRLKQ
GEIHWSTEINDALDDDRFLLYAQPIQPVMNERGMSYEVLVRMLRKDGEISPPGAFLPAAERYNSINRIDRWVVSHTFDWLNKNAAKLNKVATVSINLSGL
SMGDESMLTFIIEQLETAKIPAEKIKFEITETAAIANLRAATKFIETLRESGIHFSLDDFGSGLSSFAYLKKLKVDSLKIDGMFVKDMLIDPLDFEMVKS
INEIGHVMGLETIAEFVESEAILAKLSEIGVDFVQGYAIGKPAPIDDILNGL--------
>tr|F5SUF4|F5SUF4_9GAMM Putative signal transduction protein containing a membrane domain, an EAL and a GGDEF domain containing protein OS=Methylophaga
------------------------------------------------------------------RELSKATSRAQESERRIRDVLKKMQL--------
----------------------------------------------------------------------------------------------------
TEQQLHLSDVAFNSTSEAMMITDANKYIIAVNQAFIDITGYSQEEVMYQYPDFLVTGVSLSRLTHELWDIMQQKGTWRGEVRTITKSGDSLPSYLAISAI
YDAEQSLTNMVAVFTDMTDVKEAHAKIERHANFDTLTNLPNRRLFTDRLHQEIKRCERQKERICLMFLDLDRFKDVNDTLGHDFGDELLREMATRISSCI
REMDTVARLGGDEFTIILSEFNNAHAITVAKSLITEIEKPVIIKGQSIRVSTSIGMTFFPDDAEEPGLLIQNADRAMYAAKEMGGSAFKFYNAELESSWL
ARTFIINELESALLNGELDVHYQPIISMSEHEHLYAEALVRWNHPERGMIPPSDFLPQAERMGMIDKIDDYVFKRVCRDLKRWQSKATKTPHISINRSAH
NFGGQRGRLDWLAYLAELSLSSELITLEITESTLMQKQSESRMLLHRLRDADIKIAVDDFGTGYSSLSYLKEMDVDFLKIDRSFIHDIEESEDDRAIVEA
ITEMAKRLDIKVIAEGVETATQADILNNIGCHSLQGFYYSKPLPVAEFEVYM--------
>tr|C0N3Y7|C0N3Y7_9GAMM Putative uncharacterized protein OS=Methylophaga thiooxydans DMS010 GN=MDMS009_876 PE=4 SV=1
------------------------------------------------------------------EELSEATKRAQDSEMRIRDVLKEMQL--------
----------------------------------------------------------------------------------------------------
TEQKLLLSDVAFNSTSEAMMITDKSKKIIVVNSAFSDITGYDGTEVIGRYPSFLVSGLTKSQLSESFAAAMKAYGIWRGEIQCRHKDKTMFPAYVSMSAV
YDTDGNICNMVGVFSDISEVKEAQAKIERHANYDILTDLPNRRLFTDRLQQAILRCGRHNEKLCLMFLDLDRFKDVNDTLGHEFGDQLLKQMAVRIQACV
REVDTVARLGGDEFTIILSEFDGSHAVNIAQKLISEIEKPITVQEQTLRVTTSVGITFYPDDAIDSGMLIQNADRAMYAAKDMGGSAFKFYTTELELSWL
SRTFILNELEAAIEKGEIEVYYQPLIPANTTACQSAEALVRWQHPERGLISPADFLPQAERMGMIEKIDDFVFSQVCQQIKTWQANGIGDVHVSVNRSAH
NFGNQRGRLDWLAYIREQGINAGLITLEITESVLMRRHAESGHLLKKLRQAGVQIAVDDFGTGYSSLSYLKEMDIDYLKIDRSFIRDLEADDNDRAIIEA
ITGMARHLGIEVIAEGVETLSQKEILEKIGCHWLQGYFFAKPMPVDVFEEFL--------
>tr|I1YFV0|I1YFV0_METFJ Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Methylophaga frappieri (strain ATCC BAA-2
------------------------------------------------------------------EQLSNATERAISSEKRIREVLAQVQQ--------
----------------------------------------------------------------------------------------------------
TQTRLKLSDVAFNAASEGFLITDASRQVIAVNAAYVQITGFSESEVLGQFPKLLDQTLNDEVIFRKLWVDLNQHGLWRGELLSRRKDGEIFSVYLSMSVV
RNEQQLPSHYVAVFTDISESKQAQLIIEHHANFDLLTGLPNRRLFNDRLAQEIRHAQRDKKKLCLLFLDLDRFKDINDTLGHDAGDELLQNMASRIQSCL
RESDTVARLGGDEFTVILSGLEDDNAVQIAQKIIDAIQQPLKIHNQAIRITTSIGLTVYPDDGATPGLLLQNADRAMYSAKDANGGVYRRYNAELESTWQ
SRAFILHELETALAEGQFEIYYQPVIHARN-GAISAEALVRWRHPERGVISPAEFLPVAERMGLIGKIDDFVFAQVCFQIRHWQDNGMGDIAVSINRSAQ
DFGNLTGRLDWVDYIQQHEIASHLLTLEITEGVLLQRSTETRNLLRHLRHFGVRISIDDFGTGYSSLAYLKQLEVDYLKIDKSFIRDLETDANDKAIIEA
IIVMAKRLDIGIVAEGVETESQLRLLTELGCDWIQGFYYARPMACPDFEQFV--------
>tr|S6AIK7|S6AIK7_9PROT PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Sulfuricella denitrificans skB26 GN=SCD_n02268 PE=4 SV=1
-------------------------------------------------TYAGSVLVIMLAIVRQSRLLKATQTEALRVGKLLESFIDTVPIRVFWKDRD
LNYLGCNSLFAHDAGYTPSELIGKN---DFQMVWKDQAELRADDYR-VINSGNPKISYDEPQLPDGCKVWVRTSKVPMWSGNNEVIGVLGIYEDITEHKT
AEEDLRVAAATF-ETQEAILITDSDAKIMRVNPAFQEITGYSKEEVIGQNPRILQSGRHDAAFYQAMWAALRDTGKWSGEVWDKRKNGEIYPKSMTITAV
YDDNQQVSNYVAVFTDISQRKQSEQEIHQLAFYDPLTQLPNRRLLMDRLQQAMAVSARSGRHGALLFLDLDHFKIINDTRGHAMGDLLLIEVARRLQTCV
REGDSVARLGGDEFVVVLEELSSQDTELVAEKIRNKLSQPYALKEYECHTTPSIGISLFHGHLESVDDLLQHADVAMYQAKAAGRNAIRFFDPQMQTALD
MRADLEADLRHALEKRQFRLYYQIQVDRL-HRPLGAEVLLRWAHPERGLVFPDQFIPLAEETGLIVPIGLWVLETACTQLKAWQRDALTRLTVAVNVSAR
QFHQANFVAQVQRVLLESGAPPAQLKLELTESVVLENIEDTIGKMHEIKKLGVSFSMDDFGTGYSSLSQLKRLPLDQIKIDRSFVRDIAFDSNDAAIVHA
TIAMSQALGLNVIAEGVETEAQREFLDHHGCHAFQGYLFSKPVPLELFEEKLKT------
>tr|Q3SIU2|Q3SIU2_THIDA Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Thiobacillus denitrificans (stra
-------------------------------------------------VTIASLTVIVLAMLRQGMLLRIVTRNLEESERQKNLILHTLPDLVWLKDAD
GVYQMCNPAFERFTGRTEAEMRGKT---DFDIVGPELARKRNEDAQ-AMLADHPLTSMHALQ-VDGRDVQIESVK-TTLRRDRRVLGILGIARDVTERQR
ASEQLALVNFALNHVKEAALLADENAQFHYVNDEACRSLGWTPEELLRLKVTDIDRDLTGRGQWRALWEQIKVLNSMTIEGHYKTRSGRTFPVEVSVNYF
YGGR---EYVLSLVRDVTERKEVEAQIRSLAYFDSLTGLPNRRLLLDRLNQARLSSERTREYGALMILDLDRFKTLNDTQGHDVGDRLLIDVARRLTASV
RQNDTVCRLGGDEFVVVLEGFGSEDAEAIAEKVRAALNQPYSLSGNRFHSTTSVGLTLFCGHDATADMLLKQADVALYQAKDAGRNLVRFFNPAMQAAID
TRMAMEAALRQALERDEFHVYYQPQVDQR-ERVIGAEALLRWRPQGNEAISPLEFIPLAEETGLILPIGKWVLDVACAQLKAWESDPRAALKIAVNVSAR
QFHEPDFVATVQDSLARSGVDPTRLQLELTESVVLEKIETVVSRMEELNALGVSFCLDDFGTGYSSLSYLKRLPLDQVKIDQSFVRDVVDDSNDAAIVQA
IMAMSRSLGLNVIAEGVETHAQRDFLA-GKCLGYQGFLFCEPIPIEQWERVLK-------
>tr|A0A060NY28|A0A060NY28_9BURK EAL domain protein OS=Comamonadaceae bacterium B1 GN=SMCB_2195 PE=4 SV=1
--------------------------------------------------------------------LQRAQADLSRSEAHYRLLAENATDVVWLYDLP
QRLSYISPSVQRLLGYTSEEREQLT---IEQLFEPALATQIASHV-QRFVSGDTTVIELQHRHRNGAVVPVEISARLLLDAQGQPAQILGVTRDIRARVL
AERQLRLLSQATEQSPVAVIVTDAEGQIEYVNPALERISGYRAAEVLGRNPRLLGSQRTPRNTFVQMWDALRSDQTWQGEFINTRKDGSHYHTAVSVAPL
RDAAQRVLQYVSVQMDLSAQRAAEQQVELLAWFDPLTGLPNRKRLLAELPQILRQRPGNGEQAGLLIVNVDRFKAINDARGRNLGDAVLLALADRLRLQL
DPDELLAHLSGDEFALLLPHLGHAPLLRRAARWHQMLEQPLEAGGERLRITLSVGATLLGGMAEHPSEALHHADTALHQAQEAGGNQTVFFDPHMGQWAA
ERFALEQDLRHGIEQGELRLYLQPQVDAQ-GRTVSAEALVRWQHPQRGLLSPALFIPLAEESGLIEPLGRWMLEQVCGWLGRLQAQGRR-LPLSVNISPR
QFQQSDFGERLQELLQRSQAQAGDLMLEFTESVVLHDVERVIERMAALARLGLRFSIDDFGTGYSSLSYLKNLPIHELKIDRSFVQDAPHSPSDAALVAA
MLAVASLMKLQVVAEGVETEEQSLLFRHHPGALMQGYLFGRPEPAEELIRRWLA------
>tr|A0A060NT01|A0A060NT01_9BURK Uncharacterized protein OS=Comamonadaceae bacterium A1 GN=SRAA_2180 PE=4 SV=1
--------------------------------------------------------------------LERTQARLSESEARYRLLAENANDVVWLYDID
ERQLYVSPSVERLLGYDPQERTHLP---LAAMFEPAVVANLRSHL-ERLAAGDASWIELSHRHKDGQAVPVEISARIVFDALGRPAQVQGVSRDIRERRR
AERQIRLLSQATAQSPVAVIITDEQGAIEYVNPAFERISGYSATEVQGQNPRLLQSSRTPSETYRQMWQALLAGHIWQGELINTRKDGSHCHMAATIAPL
RDDGGQVLQYIAVQMDVTAQRNAEAQIELLAWFDPLTGLPNRQRLLADIGRALRHRNGNGEYAGLLILNLDRFKALNDALGRTEGDAVLLAVSERLRQQV
QAKELLAHLNGDEFALLMVDLGHASLMRRASDLHRLFEQTVAVGPDALSLSLSIGVTLLDGIDERAAEALRRADTALHQAKDAGGNQSVFFDARMGQWVA
ERFSLEQDLRRGIEAGELRLYLQPQVDAH-GRMVSAEALVRWQHPQRGLMGPVQFIGLAEESGLIEPLGQWVLEQACAWLGRLRTLGRP-LPISVNISPH
QFHQADFSQRLQQVLQRHEASGDDLMLEFTEGVVLRQVEQVIERMGFLSGLGVRFSIDDFGTGYSSLSYLKTLPIHELKIDRSFVQDAPHNPGDAALVAA
MLSVASLMQLRVVAEGVETEEQAAVFRRHPGALMQGYLFGRPEPAEALLARWLS------
>tr|A0A016XDD7|A0A016XDD7_9BURK Diguanylate cyclase OS=Hylemonella gracilis str. Niagara R GN=AZ34_01370 PE=4 SV=1
--------------------------------------------------------------------LQRAKQALLESEALYRLLADNSSDVVWLYDLA
DHYLYASPAV-RLFGYDPAQATSMS---FRDVLPPEVEQALYERI-AALQEGDEDLGQTPVLCGDGKLMPTEVVTTLLTDKTGRVTRVLGVTRDITQRKR
DQDQLIRLSQAIEQSPASVVITNLEGNIEYVNPAFEAMSGYAQAEVLGTNPRLLNSGRTPSEVYDTMWLTIKAGQAWHGELINRAKDGRDYVVSMTIAPV
RNAQDEVAHYLAVQLDVTQQRNAEEKARQLAWFHPLTGLPNRHRLLLDLKETLDARGPASEQCALLLLDLDRFQTVNDALGPAVGDQLLRQLSWRFAAAL
PPEAQLAHLNADEFAVLLQPARGEQALRLAQSLHDTLTMPVQLGRG-ESVSCCIGITLLSSLEDTPEDVLRRADTALHRAKNGRGGHTAFFDASMEQVVS
RRFLIERDLRRGLAAGELRVYLQPQVDAD-GQMVSAEALVRWQHPEQGLVPPGAFIPVAEESELITDVGRWVLQGVCAHLGALRTRGLR-LPIAVNVSTR
QFHQPSFVHEVQEALRVHAAAPGDLIIEITESILMEQVENVTSKMSQLAGLGVKFSLDDFGTGYSSLAYLKRLPIDEIKIDRSFVQDAPTDPNDAALVDA
ILSVARHLRLKVVAEGVETRAQADFLHARGQIVQQGYLHGRPAPAEDVLAAWEQ------
>tr|N2ISU8|N2ISU8_9PSED PAS domain S-box protein OS=Pseudomonas sp. HPB0071 GN=HMPREF1487_08193 PE=4 SV=1
--------------------------------------------------------------------TARLQRTLNTQAQRLKLIYEGSSDGLWEWIPQ
RKALYLSERFIELIGSIPDEHQPFP-QWLIEQTHPDETEALVS-MLECHLVHAPFDIELRLQTA-MGWHWFRIRGKAEREGDVLV-RFAGSLMDIDFQRD
LLAQLQESEEMVEYLPHVFWVYDSKEKVSYVSPAFQKIWGHSPELLYNATQWISLVHQDDQPLVE----RFHQEVIWHHEYRSVDANGKLLWVRNKAFPF
PNAQGEVARIVGIAEDITEARTYQEQLYAAAHFDSLSGLPNRVMFHKRLEEQCVQAGKGNREFSVLFIGLDRIKWVQQCLGQRIRDELVNQVSERFQTVL
GAKGYLANLASDEFAVLLSRE--EEMAHVHDVILQSLDEHFLLATESIRLTGCIGVAQYPLDGETAEQLIKNANAAVYAVQKSGRNGYQFFNQGLLKHSF
DTLKLEAELSRAIDQNEFVLYYQPKVDMANQQVCGAEALIRWEHPAHGLLSPLRFISLLEETGLIVPVGLWCIDQALAQLAEWQSRGLGHFVVAVNLSLR
QL-QPDLCEQVRASLERHGIEPGCLELELTESIMPEAGSESSAIINDLKTLGVRIAVDDFGTGYSTLGSLRSFVPDTLKIDRCFLNEMASNASDRAIVKS
VIEMAHALSMTVVAEGVESLEQQRLLEELHCDQMQGFLISPPVDAVIFEEKHI-------
>tr|K9RWD2|K9RWD2_SYNP3 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Synechococcus sp. (strain ATCC 27167 / PCC 6312) GN=S
--------------------------------------------------------------------PKILQTTVDEVRQFLRVIVYQ-FLPDWSGKIV
AEAV-DNPDYALLNQIIQVGRIS-----QVMNIHDS------D-MNPCYVEFAQFQVQANCQQP-RAWQEDEVN--LLKQLATQV-GIAVSR-------K
LVTALKEQEAIVEDQTELIYRCSSDGILTFANAAFCR---YLHLIEPGEIKADQCYFDFNEVETA----RFAQQLAAAHDLPS----GDQAWYEWTMRAL
YDSANQLREYQCLGREITRRKKVEFQLIHDALYDSLTGLPNRVLLLERLNQAWNRYRHPDCPFVLLFIDVDRFKRINDSLGHQAGDQILMTLAERLQVVL
RATDTLARLSGDEFVLLAEDINGIDLDHL---IQQTAEQPITIYDNLIKLTLSIGVAWSSEAYSQPDELLRDADIAMYQAKRRGRHQCLTFTPEMHLEAR
FTLSLESELRSELTATPLQIYYQPIVDLSSRHVIGLEALCRWFHPRRGVISPSEFIPLAEETGLILPLGQWVLKTAVAHFSQWYQTLGNIPKLSVNLAPQ
QFLQSNLVNDVADILETYDLPPKYLHLEITETAMMTSLDVVVRVARQLQDLGVFLNIDDFGTGYSSLSRLHQLPIQALKIDRSFVLRLDPSQASGDIIQA
MLSLGQSLEMDVIAELPAKGLTVYQFRRTACC----------------------------
>tr|V5V7U9|V5V7U9_9CHRO Class II cyanobacteriochrome OS=Thermosynechococcus sp. NK55a GN=NK55_11135 PE=4 SV=1
--------------------------------------------------------------------ETVLKTALEEIRQLLRTVIFQ-FYADGRGEVV
AESV-AAPQFSLLNRTFAAERVL-----ALADINTA------T-IAQCHRDFNQLQVRALCSSP-RPWANDEVE--LIRQLGEQL-GFGIHR-------E
LVSALHQEKRVLEAQTELLYRCTPEGHLTFGNPAFFR---YLAEV------GVSCDLGFDPVTQQ----RFQQHLQTTQTLSTGQSTGQLAWFEWTTRAF
FDHHGRCVEYQCVGHDITRRKQMEEQLIHDALHDPLTGLPNRTLLQERLQHCWRQYRRGDRPFAVVFIDIDRFKRVNDSLGHQAGDQVLITLAQRMQSVV
REGDTLAHLSGDEFVVLCEDLDQQMVAQVQARIERVIQEPLIIDGHLLSLSASIGVAFSDREAASAATLLRDADIAMYQAKKQGLGQCRIFDPQMHTQAQ
SCFTLESQLHQAIANSELQVYFQPIVEMNTGAIVGLEALSRWFDPEKGEIPPSEFITLAEQAGLIVSLGRQVLERAIQEFSQWRQQDSQTMTLGINISPQ
QLVDANFVGDILAVLRSAQLPPHLLHLEITETTMIRNLEATLQVAEELQQLGVALNIDDFGTGYSSLSRLHQLPIHALKIDRSFVQSLEESRAAQEIIGA
VIALGKSLRLDVVAEGVETAVQAAQLMDLGCLYGQGYFFYPPLPIDRLP-----------
>tr|B7KEN2|B7KEN2_CYAP7 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cyanothece sp. (strain PCC 7424) GN=PCC7424_0596 PE=4 SV=1
--------------------------------------------------------------------RKHIEEALRESEQKYRLLFYANPNPLWVYDVK
------TLAFLEVNQ--AIEREEFL-GMTLRDIRPS------E-DVKILETYAN-------NRS-GYWQHRKSNGEIIEITSHGI-EFAGRQNDITEQLK
AQQKLQESERAVIDAPLPILIHAEDGEIIQVNHAWTELTGYTHEDIPTIADWTEKAYGIDELY-------------KDGTIKT----GETRIWNFSSAPL
GRLADNRRLIMSMALDITERKQAEEQLRHAAVHDQLTGLPNRILLLDRIEQAIKRTQEEKYLFALLFIDLDRFKVVNDSLGHWVGDQLLGAIADKLKACV
RPMDTVARFGGDEFVILLENLTRTEATKMAQQI--ELRSSFCLQGQDFFISVSIGITFPSSYEESASELLRNADIAMYRAKEKGRARYTIFDSKMHIQAT
RLLELETNLRLALEREELIVHYQPIVSLTTGKLLGFEALVRWEHPKKGLISPGEFIPIAEETGLIIPLGEWVLLESCRQMKAWQKEFSDKIRVSVNLSGK
QLEYPHLINCLESILKQTGLEGKNLKLEITESMLMNNKEVVSDLLLQIKGKNIQISIDDFGTGYSSLSYLHYLPVDTLKIDRSFVNRMTQLGENFEIVEA
IINLAHHLQMDVVAEGVETEQHIKQLKQLGCESGQGYFFSKPLDSQKVTSWFE-------
>tr|Q0A846|Q0A846_ALKEH Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / M
----------------------------------------------------------------------------LQDEARLRAISDTMNEGMYVFDGE
GRITHVNRAAETLLGYRASELIGAH---AHDLFHAHGPEGMPCPVYRAAVRGERLQDSEWFRRRDGSHVPVQIFGAPIGDGSRPNPTYVVTFVDETERRR
EREALRKLSAVVEQGPGAVMITDPQGVIEYVNPAFERITGYTAEEAVGQTPRIIQSGLMPSSWYREMWAALNRGEPWWGEFHNRRKTGELFWEAGVVFPL
RDDQGGITHYIAIKQDVTERKDAERRLEYHATHDTVTGLPNRALAMDRLETAVRRLAHGRGSGALLVLDLSQFRKINESLGHASGDELLCRIAERLQGAL
GPHDTLCRPGGDEFLVILPELRTRQAEQVAKALLATLKAPLVLADQEIFMDARVGVTLFPEDGTDSSTLLRNAYAALSQAKQVARGDFRFFKPEANERAH
RWLALEGRLRRALEQETLHLVFQPLVDARTLRPTGFETLLRWTLEEHGPVSPGEFIPMAEETGLIIPMGEWVLRKACQQAARWRAQTGHCYRMAVNVSPI
QITGSDFVATVRTSLRRTGLPAECLELEITERMLLGGQRRVLQSLQALRDLGVGLSLDDFGTGYSALSYLRQMPFSVLKIDRSFVQGAAAGPRGEQLLCS
IIGMAQGLGLRVVAEGVETEAQVALLQREGCDLLQGYHFARPMAAEAVTRLLQGPE----
>tr|Q2RWS9|Q2RWS9_RHORT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 
----------------------------------------------------------------------------LREREDMRAITDTMGEGLYILDNE
GLIAFVNRSAETMLGYSREDLLGAK---AHSLFHSHDGDGQDCAILRAMRERRHFTSDEAFIRSNGTRFPVEVRCAPLTAGNRNPRASVITFVDITERKA
SEAALRKLSRAVEQSPASVIITDARGTIEYVNPQFEKSTGYRSWEVIGANPRILKSGHIAEATYAEMWKTLNEGREWRGELHNRRKDGTLYWEYASLSPV
KDRRGRTTHLLAVKEDITARKETENRLIRQANFDELTDLPNRSLCYSRLKEAIVEAEATASIVGVLFIDLDHFKNVNDSLGHAVGDKLLTAVAQRLREVA
RPGDTLSRQGGDEFLMLLPDLNGEAGHGVAQAILTALAPPFSIDGREIYMAASIGITFFPRDGRSAAELLRNADSAMYTAKESGRNAICFFSPEMEIRAA
QRLAIEGALRQALAHEELRVAYQPLVRTSDARPIGAEALLRWTSPTLGEVSPTEFIKVAEETGLIVPIGAWVLDQAVAEAARLRAEGYGAFQIAVNVSVR
QFRGGDLAGLVSDTLKRHDFPAAGLELELTESLLLDVTPAITTTLQSLSALGVRLSLDDFGTGYSALSYLKTFPFDILKVDRSFIRDISSAPDSGALARA
IIAMARGLGLATIVEGVETEEQCAFARAEDCDIMQGFLFGKAMTPADLRRMLDEKA----
>tr|G3J290|G3J290_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Methylobacter tundripaludum SV96 GN=Mettu_2965 PE=4 SV=1
-----------------------------------------------------------------------------ESLSILKATLEATGEAILAVDLN
NNWLLHNQKFIDLWQIPDEVIAAKIGGNAELLYGPNQPE-AFSNKVTGLATANSFDI---IEFKDGKVV--ERYSIPKI-INNKVVGRVWSFRDVTEQKQ
AEAELRIAATAFES-QEGMSITDANQTILKINKAFTRITGYSPEEVIGKTHAMLNSGRQDVHFYSVLQHTLKQDGYWEGEIWNRRKNGEIYPQWLSITTV
SDANNQITNYVAAFTDITKDKEAEETIHNLAYYDPLTALPNRRLLWERLKHGIEVERRDGKQLALLMLDLDRFKAVNDSMGHLAGDELLQQVAARIKARL
RDVDMVARLGGDEFIVLLEDITHEDAARVAENIVADLSKPFQLLSRKVRIGASIGISLFPQHGDSPETLLDNADIALYRAKDEGRGCFAYFSEEFTIIAR
ERIALETRLRRATEQRELCVYYQAQIDIDSGLIIGAEALVRWHDPAAGLISPANFIPIAEETGLIVEIGAWVLRETCLQGRRWIDAGLPSLTLAVNVSPH
QFRRSDISALVAEVLSETGFPAELLELELTESGLMENEEKAVEVLNNLRAQGVRLAIDDFGTGYSSLAYLKRFPLDVLKIDKSFIDDIPSVQDDMEITAT
IVAMGHILGFKVLAEGVETLEQLAFLREKGCDTYQGYIKSKPLPAEDFAQLLRD------
>tr|Q2BRK3|Q2BRK3_NEPCE Uncharacterized protein OS=Neptuniibacter caesariensis GN=MED92_06886 PE=4 SV=1
--------------------------------------------------------QLYSRLVETLRSNAQQQKDLERSEHRLQNFDKVSSEAIF-IHNS
EGIVDVNKQAEKMFGYTHTELLQLK---PDDFFSAESLPVME-----KVRTQSETPYQATVITRDGTAIPVTVNGKAVLWGQKA---RAASFRDITRRIE
YQKRLMASEDRFDLVAEGLLI-YSENKIIDVNQSLCELFGQRREDLLESDLSELFS--------EQSLTAINNHPDTAAELSLERADGTLFPAEITTASM
QFDDGLF--IVLSIRDISRYKEQEEHILYQAQFDLLTHIPNRFLAKDRAEQAIRNADKHDGKLALMFIDLDGFKKVNDSMGHEVGDQLLQQATRRFVSCI
EKQHTLARHGGDEFIIIQEDIADTDSEIVAEKILQQFSNPFSIENKQLIVTASIGISIYPDDANNYSDLLRAADIGMYKAKHDGRNRFHYYTQEMNDIAT
RKLALDNSLREALQNREFNLVFQPLICNVQPKVQGAEALIRWTSPVLGQVSPVEFIPHTEQSGLIIPIGRWVLEQACQQAKRWVDDGQEDVFISVNVSPR
QFKGNDLLRDLTSALESSGLHPHHLNIEVTEGLLIEASPELNNTLQLITDMGINLSMDDFGTGYSSLNYLKKFPFNNLKIDRSFIKELPDNSDSAILVTA
TIAMAHQLGLSVTAEGIETAEQYNYLRGLRCDRLQGFYMGKPVPANEFSFELA-------
>tr|D5CNJ0|D5CNJ0_SIDLE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sideroxydans lithotrophicus (strain ES-1) GN=Slit_0663 PE=4 SV=
--------------------------------------------------------TVVS-LTFYFRSIRQSRSAVAASEQRLRLILGSVSNGIWGLDKD
GNTTFVNAAAADMLGYTPEELFDKP---MHATIHH-SYPDTH-------YPAERCPMHATLVD--G---KPRMGIDEVLWKDGSELGAVVVFEDISERRQ
KDEALKLASSVYQSSNDGILVTDEKNRILDVNPAFTRITGYTLEDVRGKDPGIFQSGKHDAQFYQQMWQSILDDGHHAKSSVIRRADGSIYR--------
---------HVGQFSDITEKKRKDELIWEQANFDTLTNLPNRRLFADRFRQAISAGARSGRYGALLSLDLDQFKRLNDTFGHSMGDKLLIEVARRLTSCV
REEDTVARMGGDEFLVILNGLGSQNEELIAEKIRNELCRPYQLDKTEHHSSSSIGIVLFRGHSDDPERLLAHVDTAMYQSKAKGRNAICFFDSSMQEILE
KRGQLETALRGALERKEFLLHYQLQMDS-SGRPIGAEALLRWNNAKLGSVSPVQFIPVAEESGLILPIGHWVLETACAQLARWQSDPFNRLCIAVNVSAI
QFREAAFVAKVRNVLQQSGIQPWLLKLELTESLVLDDINDSILKMEALKNLGVKFSMDDFGTGYSSLSYLSRLPLDQLKIDQSFVRDITTTDQHAAIVQT
IISMALSLGMEVIAEGVETEEQREFLDLRGCQAYQGYLYAKPMPIEELEIKLA-------
>tr|R4YSS0|R4YSS0_OLEAN Uncharacterized protein OS=Oleispira antarctica RB-8 GN=OLEAN_C10580 PE=4 SV=1
-------------------------------------------------------------------------KKLHMRQEQLLENQAIAKIGSWTLDND
SETLKCSPEVYKIFEVEIEKDINFD--LFMQFVHPDDRKNAEEIIGNSIEEKAAYNFVYRIISSSGKLKYVQGRGQAIVDDAGKLLRRIGSVTDVTEHKQ
AEEKNRLSAIMFESTQEGALITDKNTYIIAVNKAFTDITGYSEEEALGNRPNLLKSGKQSKKFYARMRDSLDKNGSWAGEICNKRKNGDFYPEWLSIKNV
YDDNDKIINRIAVFSDISHLKKTEEQIEKLSYQDQLTGLPNRLLFQSRLSHALDVAKRNKYPLAVMYIDLDHFKNINDSLGHSVGDEVLLMIAERLKNRV
RESDTLARIGGDEFILLLEQIDDEQVAYVAQSILELMAEPFEFNGKNIFLGVSIGISFYPNDGLSASELISHADAAVSQAKDNGRNCVHFYTLELTQAAQ
ERMRLESELRRALVNSELQLYYQPQVNIESGEVVGAEALLRWHHPSDGVISPLVFLPVAERSGLMAAIDYWVLETGCQQQASWKENGLPFFILAINITKY
SFMDASFLSQINSIIKATGVNPETIELEITEGALIEPSPQVIQTIAELKRIGFTLAIDDFGTGYSSLAYLQRFNVDKLKIDRSFVKDVLTDAQGEAITSA
IISMAKSLNLEILAEGVEDKEQLAFLKEKGCEIYQGFYFSKPIPVKEFEALIRNY-----
>tr|L8MMM4|L8MMM4_PSEPS Diguanylate cyclase/phosphodiesterase OS=Pseudomonas pseudoalcaligenes KF707 GN=ppKF707_3752 PE=4 SV=1
--------------------------------------------------------------------VLSGEQRLQEQLDFTSAITDSVGEGLLAVDRQ
GRLTFVNPAAATLLGKPVDALLGRP---LAELL-PLDLYD---AGASATRHGE-----M----GLGGERHIAYDCAPLLHAR-ALGGWVIAFRDISRTRQ
SEEQLRILQRSIEASYNGALICDADLPIIYVNPAFERITGYSAGETLGRNCRFLQGPDREQTGIAEIRRALEEQREVHVVLRNFRKDGTPFWNDLYIAPV
PDEHGRITHFIGVQNDISEQKRVESELAYNASHDVLTGLPNRSLMEDRLRQGCQISQRYRRKLAVMFIDLDGFKPINDSMGHGIGDQILVEVARRLSQQV
RPGDTVARLGGDEFILILPDLAREDVLQVAERVIDCIARPYPIAGSELHITASLGIALSEKGMQQPMQLIQQADLAMYKAKQQGRNCYQWYTTDLEQKVS
ERVTLRNELQKAIESSAFMLYYQPQIDGRNGRVTGYEALLRWQHPLLGFISPAQFVPVAEDTGQIIPLSEWVLATACRDCRRLMDQGVTGTVVAVNISAV
HFQRNIFVDTVRRVLEESRLPAELLELEITETVLLDNAERAIATLQALKALGVRLSIDDFGTGFSSLNYLKRLPIDKVKIDRAFVQEVISDHHDAAITQG
IISMAHHLRLRVIAEGVETESQFAFLKKSHCDEFQGYYFARPMPFDQLERFFHEH-----
>tr|A0A0A1YKK7|A0A0A1YKK7_9PSED Diguanylate cyclase OS=Pseudomonas taeanensis MS-3 GN=TMS3_0117275 PE=4 SV=1
--------------------------------------------------------------------VITGEQRLKTQLDFTSAITNSIAEGLLAIDGE
GHLNFINPAAAALLGQPVSTLLGQP---LVQHL-PLPLEQ---TQG---HHGE-----LRLPQGAQSERYIAYDSAPLLDDD-GPQGWVVAFRDITAHKE
ADKQLRLLQRSLEASFNGALICDADMPIIYVNPAFERITGYSAAEALGRNCRFLQGEAREQPGIGEIHRGLALQQDVHVVLRNFRKDGTPFWNALYIAPV
PNELGEVTHFIGVQNDISEQKRFESELAYNASHDVLTGLPNRSLLEDRLSQGCRISNRYKRNLAVMFIDLDGFKPINDTLGHIVGDQILVEVARRLNLQI
RPGDTVARLGGDEFIVILPDLAREDVLLVADRIVESLARPYQLTHVEQHITASIGITLSDGNIEQPMQLIQQADLAMYKAKQQGRNNYQWYTEDLNQKVS
ERVTLRNELQKAIETEAFQLYYQPQIDGRSGRVVGYEALLRWHHAERGFIPPAQFIPVAEDTGQIIPLSEWVLNTACRAARSLADQGFNGAVMAVNVSPV
QFQRANFVEQVRSTLEQTLLPAELLELEITETVLLDNAEKAICTLHALKELGVRISIDDFGTGFSSLNYLKRLPIDKVKIDRSFVQEVISDRHDSAITQG
IISMAHHLKLKVLAEGVETEPQLAFLKKSRCDEFQGYYFAKPMPLPQLEGFLHQQ-----
>tr|Q5KZY8|Q5KZY8_GEOKA Hypothetical conserved protein OS=Geobacillus kaustophilus (strain HTA426) GN=GK1463 PE=4 SV=1
-----------------------------------------------------------------------------NCMDKYTAFFHHFTEAVVILNLQ
GVIIYNNPAFAGLALSEEEQR---T---L--SV-----------------EGRALVERVKQRPAAFRWELLVAGVSPIIGENGQTAAVLCVLRRQAEESG
LQARLAEAELIVEHSNDYVLIFSPNRELSYIPPSWKRKTNKRLPVS----YEEVLTHPDDAVVAQKLAELY-DTYETQSEFRKQGEKGEWVWMEAQGKAI
IDEAGTLDCVIVTVKNISERKRYEEKLRQLAYFDSLTGIANRSYFERHIHEL----IASQTPFALCYLDFDKFKWINDHFSHQAGDYFLREAVKRVERAL
RPGDFFARIGGDEFVLLLPNITKTEMTALAEQLVSSFHEPFYYEKQLIQSTLSIGIAFFPKDSDRIEQVMKYADQALYEVKERGRNGYAFYRPTEHRHAV
----IEQDLPFAIMRGQLYLCYQPKVQLAKGKAMGVEALLRWRHPSLGEIPPLDFIPLAEESGFIFEITLWVLEQASRQVKEWERKF-PGLKLAVNLSPF
LLNRPELIEHVKRILRETGLSPDRLILEVTESGLMENIETGQHILTELQRLGVQAAIDDFGTGFSSLAYIRNLPVSLLKIDRSFIEGIAENSKDATIVDT
IIHLAKSLDIEVLAEGVESESQVALLSQMHCDYAQGFYFSRSLEAEKLQQWLEEY-----
>tr|T2G6C6|T2G6C6_DESGI Putative PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Desulfovibrio gigas DSM 1382 = ATCC 19364 GN=DGI_01
-----------------------------------------------------------------------------AVEAL----FQELPQPLLLLNAA
GRIQQANPAALALLGESAQSR---S---F--AL-----------------SRGLPPLEVEAHRSQLTWHG--------------QPGWLVSLQDLTERTV
LRRTLDDTAVIADHACSWECWILPHGAYAHVSPSCERITGYEAQQFLD-DPLFIQGEEEDLAWKDFMHASATTRGDILHDYRLRRKNGRQVWISQTNCPV
HARDGSLLGLRTSAQDITARKQMELELRRQTLHDQLTGLPNRALFLDRLEHARLASRRSDYFFALCFLDLDRFKTINDSLGHTAGDKVLVEVTRRILDSI
RTLDTVSRFGGDEYAILLEELVSPGAVQIVKRIRQLISEPLVVNDSELRITASMGVVLSPMDNLPAEMLLRNANIALHAAKEQGRDCFKVFTNKMLDQAV
MLMTMEQEMRRGVQGDEFFLVFQPFVHLHTSELVGFEALVRWRHPTRGLMPPGAFIALAEETGAIIDLGSMVLHKACAAWVAWAEQW-PAVRMSVNISGR
QFSQFGFLDSIRTVLEKTGMPPERLKLEITETAIMEDAESSAEKLSRIKEMGIALSIDDFGTGYSSMSYLQRFPLDNLKIDLSFIRLMHVSQENMEIVRA
IINLAHTLGMEVVAEGVEDASQRRTLQELNCEYAQGYFYARPMPDDEMRAFLAGL-----
>tr|E8N132|E8N132_ANATU Putative signaling protein OS=Anaerolinea thermophila (strain DSM 14523 / JCM 11388 / NBRC 100420 / UNI-1) GN=ANT_27490 PE=4 SV
-----------------------------------------------------------------------------NNEAYFRLLLENSLEVIFVLDAD
YRIRFASPSLRLTLGYPPFQR---N---F--LV-----------------EHSIQALRVRLQHLDGSWHIFKSRL-----QDEQIKGIILNSRDITEQQL
VYNALRESQTLAANDGIWDWN-IKSGR-VYYSPRWKEILGFTEGEIGH-RMEDWYALPEDLSFQSALNSLLSGATSRLEEIRMVLKDGGTVWVLVRGLAM
RNREGEAYRIAGSMSDITERKQAIEQLTRAALYDTLTGLPNRTLLLDRLGMAIESRRAGGTFGAVLFLDLDQFKVVNDSLGHPAGDEMLIQVGHRLQKCL
RASDTLARFGGDEFVILLESVSSRDVLQVADRVQHALSEPFEIAGRKVFTTVSMGIVIGLKQYNTREEVLQDADIAMYRAKSSGKARYVIFDATMRKRAI
NRLSLEMDLRHAIEQNHLYLVYQPILELQSGALIGFEALARWQHPEHGLILPADFIPIAEETSLIREVGRWVLREACRQFAPIFYQT-KHIRISINVSSR
QITESGFVEYIRETLEGYRLPPTCLKLEITESALIESVDIARHVFHQLRQMGVDIHVDDFGTGYSSLSYIHRLPVDVIKIDQAFVQKLGEDEQSLEITRS
ILHMARSLGIKTVAEGIESQQQYLFLQQMACEYGQGYFLSQPMTIAQVEDFLKSL-----
>tr|A0A099KV35|A0A099KV35_COLPS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Colwellia psychrerythraea GN=ND2E_2190 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------WTKQETFLSEAAFKTIDGRE----IKALISFQSTNHFRNVPVSIVDITELKK
LEKELRLSSRVFSDTHEGIIITDADKIIVDVNPAFTDITGYSREEVIGKKPNILSSGKHQPQFYSMMWQQITDQGYWQGEIWNRRKNGEIYAELLTTSLL
KDSDGHIVNYLGMFTDITHSKRQQESMRRMAHYDQLTGLPNRALLFDRFNQAIAHSKRSGTLLAVCFLDLDDFKPVNDIFGHDVGDKLLIDVAHRLKLAL
RSEDTVSRLGGDEFSLLLGDIKSNQCYEMLERIIHSISATYFIDEHSINISASIGVSLSPLDGMELDSLLRHADHAMYQAKQEGKKNYQLFDLEREQKTN
RRHVKSQEIQQALINHELCLYYQPKVNMASGKLIGVEALIRWQHPVKGLLSPVDFLPLIEGTDIEIQVGEWIMEQSMTQLERLNTEGFT-IEMSINVSSM
QFLSDCFLDSLKASLKRHAINARHFKLEVLESSTLGNLKRISKIISACRDLGVKIALDDFGTGYSSLSHLRQLPADTIKIDQSFVRDVLIDPDDFAIIDG
VIGLSKSFSRDVIAEGVESTEHGLMLLLMGCKNAQGYAISKPIPTDKLVEWIKAY-----
>tr|M1FJ41|M1FJ41_9ALTE Sensory box protein OS=Marinobacter sp. BSs20148 GN=MRBBS_3616 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------ELAFQNAEKRELV-LANEELAFQKDK---RADELIIANEEKEK
RASELALAASVFTHARECIIITDADATIIDVNDTFIHITGFSREEAIGQNARMLQSGRQSRDFYIVMWHALLTDGYWSGELWNRRKNGEMYAEMKTISAV
QNKHGIITHYVSLGNDITPMKKHQDQLEWLANYDVLTSLPNRTLLADRLGQAMVQSQRHHNSVAVVFLDLDSFKDINDSHGHDVGDELLIIVSRHMKKAL
REGDTLARIGGDEFVAVLADLASEDYEPVLERFLLAASQPITVGEVVIKVSASIGVTLYPQDNVDADLLMRHADQAMYVAKELGKNRYHFFDTVQDNALK
VKMENLKTIRSALDNHQFVLYYQPKVNMRTGLVMGIEALIRWQHPERGLLNPIEFLPVIEKNPMIIEMGEWVIDTALTQISQWQAVGID-LPISVNIAPI
QLRQPYFAERLATLLSAHDVEPRYLELEVLETSALDDFQHVSTIMDACIKLGVNFALDDFGTGYSSLTHLRRLPARLIKVDQSFVRDMLVDADDLAIVEG
AIVLVKTFKREVIAEGVETIEHGTALLQLGCELAQGYGIARPMPASDVPAWISDW-----
>tr|F1W1D0|F1W1D0_9BURK Uncharacterized protein OS=Oxalobacteraceae bacterium IMCC9480 GN=IMCC9480_42 PE=4 SV=1
--------------------------------------------------------------ISQ---RKRDELELSTNRAFLQSLIDHLPVIVYSKSMY
GQFVLWNKAAERLTGLSAATVIGNT---NRDLFAPGAAV-YDAHDHEIMVLSSVGIPSHPVRAQDGTARILRTHSLPVFDAAGKVDFILGISEDITALHA
EQLALQASEVTLNSIGDAVITTDMQARVTYLNPVAERMTGWLLGDATGRPLTEVFRIYHDDVPLSDPVAQVIATGVASAMLAGPGPGGTRAAIEDMASPI
RDAGEVMLGVVLVFHDVSEAHKMAEQMTHLAAHDALTGLLNRREFEHRLEQAVASASRDSQEHTVMYLDLDQFKIVNDTCGHVAGDELLRQLTTLLHAKL
RQSDTLARLGGDEFGVLLEQCGTALRVTVSDFHFVWLDKSF-------PIGVSIGLVTF-GAGMTTPDILRMADSACYVAKDKGRNRVHVYSEENAELVH
RQGQWVARLQQALDEDRFVLFCQPILGLGQHHGRHEELLLRLRADDDTLIPPMAFIPAAERYGLMPSLDRWVIRRALAT-HALRHPPGSPVLVAINLSAT
SICDETFLPFVLAQFTLTGVPPSEICFEITETAAIANLGEATVLIRALKAIGCKFSLDDFGSGMSSFTYLKHLPVDYLKIDGSFVKDMMDDPVDRAMVEA
IHRIGHVMGLQTIAEFVESDAIMAALREIGVDHAQGYAIGKPVPCVAC------------
>tr|K0I0Z2|K0I0Z2_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Acidovorax sp. KKS102 GN=C380_14975 PE=4 SV=1
--------------------------------------------------------------VSE---SYRVRRKLEDNEARFRTLTALSSDWYWEQDAF
-RLTHVEGRADDRLVQEAALHMGKT---RWELAAPGDPL-WEEHRSLLERHQEFRDFEFERRDQQGCSYWVSISGTPVFDDDGVFCGYRGVGKDISARKR
DENELRIAA--AFESQEGMIVTDADTLILRTNRAFSRITGYNADEVVGRRTSLLASGHHDKVFFDAMWASLASTGEWKGELWNRCKSGEVNLHFMAITAV
TDQHGVLTHYVATLSDITQRAAAAREIEHLAFYDPLTHLPNRRLMMDRLQQAFATSARAGLQGALLCLDLDHFKTLNDTLGHDMGDVLLQQVAQRLTACV
REGDTVARLGGDEFLVLLEDLGATDAATVGEKILAALNQPYQLASHHVHSTTSVGAVLFSGQGQTVEDVVKHADLAMYAAKTAGRNGIRFFDPRMQAAVT
ARAALENDLRTALEQGQFTLHYQVQVGCGKHVV-GAEVLIRWNHPARGMVPPFEFIPLAEETGLILPIGLWVLQTACTQLRRWQDDPATHLQLAVNVSAR
QFRQADFMEQVVAVLRQTGARPDRLKLELTESLALDNVDDTIAKMNALRALGLRFSMDDFGTGQSSLSYLTRLPLDQLKIDQSFVRNIGIQHTDALIVQT
IIGMAQSLGIDVIAEGVETEAQRAFLERHGCTLWQGYLFSRPVPIEAL------------
>tr|J1EHG6|J1EHG6_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Acidovorax sp. CF316 GN=PMI14_03603 PE=4 SV=1
--------------------------------------------------------------VTE---SYRVRRQLEDNEARFRTLTMLSSDWYWEQDAL
-RFVMLEGEAAKRTLPGPQWHVGKT---RHEVATDDAVD-WAQHEHALRERREFRDFEYPRQSTVGAVEWVSVSGTPIFDADGVFLGYRGIGNNITARKN
AERELRIAA--AFESQEGMLVTDADTVILRTNRAFTKITGYDSADAVGRRASFLASGQHDTAFFTGLRRTLDSVGEWSGEIWNRCKDGQVSLHQMGITAV
KDAQGRLTHYVASLSDITQKAAAAREIEHLAFYDPLTLLPNRRLMMDRLQQAFASSARSGQYGALLCLDLDHFKNLNDTLGHDMGDVLLQQVAQRLKACV
RDGDTVARLGGDEFLLLLKGMSSTEAATVGTKVLAALNQPYQLALHHVHSTPSIGAVLFSGQSQSVDELMKRADLAMYAAKTAGRNAVRFFDPRMQAAVT
ARAAMENDLRTALAEDQFRLYYQVQVGQGGRAI-GAEVLIRWQHPERGLVMPGEFIPLAEETGQILAIGLWVLRTACLQLRHWEDDPARHLQLAVNVSAR
QFRQGDFVDQVFAVLSETGARADRLKLELTESMALDNVQHTIARMNALRALGVGFSMDDFGTGQSSLSYLTRLPLDQLKIDQSFVRNIGIQEADALIVQT
IIGMAQSLGIDVIAEGVETTAQREFLALHGCNLWQGYLFSRPVPLENF------------
>tr|A3YCV2|A3YCV2_9GAMM Uncharacterized protein OS=Marinomonas sp. MED121 GN=MED121_09840 PE=4 SV=1
-------------------------------------------------------------------------------------PLVKLKTAVWIYDID
NCISWANDKALDLWEADLKELQTRD---FKKGS-SDAVRSSLLDYQQAFKKGETRGEFWTFTPKDVKKALLIMSGYKLED--GRMAMLCEALTL-D----
----LI-PDMELVGSTVMMSSYNVDGTFISGNPPFKEDIGTDDIGL----DELIVLNSKLTQIYA----ELNSKGSFKGDVLCRRQGLE---VWYHLEAT
LSSQDNDKKILIHQYNIHHRKLQERALEKDSHTDLLTGLLNRRGLFDRLQS----YRDKKKPFVIFYLDLDGFKMINDSFGHGCGDQVLKSVSARLSATL
FSKGYACRFGGDEFIWTCGLDDLLPMDVLSEKLLNAVSHTFYGDGVPMDVSASIGYASYPKDGTNTQEIISCADAAMYIAKRTGKRRTVYYRPGMEKENK
RLGILAQNLAQAIKNRELSLHYQPIYNVETNSIDSYEALIRWQCESLGYISADETIRIAESTGLIHSIENWVIRQALQDLKEFREGADQTVRMSINISGL
HLAQVDFVNSLEEKIIQAGLVPQDVILELTETTLLDGIDDEDSNLHQLHKLGVGISIDDFGTGYSSLAYLHKIPADVVKIDKSFVEQV--SKDK-RTIDY
IHRLISSLGKKTLVEGVETQEQKEIVQSLGINLHQGYWFSRPQSLMFFKSKPIEP-----
>tr|K6YJ23|K6YJ23_9ALTE Uncharacterized protein OS=Glaciecola arctica BSs20135 GN=GARC_1192 PE=4 SV=1
-------------------------------------------------------------------------------------ALDRLHTAVWIFDID
QCMIWANQAALKLWDSPLEELLTRD---FKSDL-SAAVKETMLQFQQAFQNNEVIQESWQFSPKGVAQAFCQFSGYLLEN--NSMAMLVEAIPT-N----
----VL-HSDLQLGSTALISIYRENGDFLSGNPPFIPEFGHQVKHL----KQLFCNPDVLTNLYQ----SMVKELRFEQDVLMRTKVGE---TWYRLFAT
KSINQGEATILLHQYNIHERKSIEQTLREQAWTDPLTALLNRRGLAHALTQ----SIDNNTPFTLLYIDLDGFKMVNDSLGHGKGDLILKEVANRLRQHQ
YSSGQLCRFGGDEFVFAIHNDDIGQINVLSEQLIKQISEPYENVGSSLSLSASIGISCFPEDGDEIEHLITCADAAMYQAKKLGKKRWVNYISGMENVHK
RASSIAYKLSSAIQNNELELFYQPIYNIETGSIYSFEALLRWTNAELGQVSPQETILVAEQTGLIHEIENWVLNQALSDLAKLRSVTEKSATIAVNMSGL
HMAQPKLLETIIAMLDVHGLQPVDLTIELTESVLLSDIDKEQNPTQQITSNGIKLNIDDFGTGYSSLAYLHAIPASVVKVDRSFLDQA--DNNT-VTLEC
IHTLVNSLNMQSLIEGIETNHQSQLLASLGYNLQQGYLLGRPQPLAYYFTETFCY-----
>tr|S6HUZ3|S6HUZ3_9GAMM Uncharacterized protein OS=Osedax symbiont Rs1 GN=OFPII_03170 PE=4 SV=1
-------------------------------------------------------------------------------------DCNDLSTALWVYDID
NCIYWANKAALVLWEAALNELISRN---FKFET-SDAVQKTLLGYRSAFESGKSVSMFWRFTPKDPKETFCQMSGYQFAD--GRIGLQCEAIPA-Q----
----LI-NEQASQSSIIMLSTYDINGNFISANPAFIDQMGQQISQL----SQLFTDSDHSRDVFK----SIRQKKNHTSDYLLNTVSGD---QWFHLQLS
ISAEIDNSEILVQQFNINQRKLEQINLTKQANSDPLTGLLNRRGLKEKLAK----NIETNTEFYIYYIDIDSFKMINDSMGHAVGDSILKTLAQRLDS-T
FKQAIVSRVGGDEFILVVNKGEYSQGD-IANSLLELTNLPYTVLDTPVLVSASVGSANYPRDGTDLEKLLLRADAAMYVAKSQGKKRGISYSKGMEDSLQ
RRSLVARYLYLAIENSEFELHYQPIIDTSNNSIYGFEALLRWHNPSLGLVPTEEAITIAEQIGIIVDVENWVINQAIADLTKLRQATDSQALLSLNISAI
RFIDPQLPTYLLQVLAEHGLSASDLEIELTESTLLKDINNEHNSAKAITDQGILLSIDDFGTGYSSLAYLHQIPASIVKIDRSFTARI--TESS-ATISS
IHHLLKSLQLTTLVEGVETEQQSKMLKLIGINLQQGYGLGRPKPLSYYLDKSKPS-----
>tr|N9VIL0|N9VIL0_9GAMM PAS/GGDEF domain-containing protein OS=Aeromonas diversa 2478-85 GN=G114_13063 PE=4 SV=1
-------------------------------------------------------------------------------------TLDLLHTPIWIYDIQ
ERIFWANQAALAVWEADLAELQQRD---FSLEM-APAVDLLLQRYLREFQSGRSFCEWWSISPKGSKKVYLRLSGIEIA---ERLMMVGEAVLDAT----
----LS-HEAAMVQGDTLACLFDDRGELISANHYFQKCFGTQIREL----NQLYGGGDEH--FYR----KLRLKEELVCEGEARTAKGM---RWFQLQFR
YV--QQRSQILLTLRDITARKLEELEHRHLARHDYMTGLLNRYGLMKSLEV----NCSMGARFALLFMDLDNFKLVNDNFGHRAGDRLLERVAGRLKEIC
PSDVELARLGGDEFTALVPLGGDERAHRFADLMLEQMARPFSLSLPEVTIGGSIGIALYPDDADDGDNLITRADMAMYQAKHLGRFTWQRFTPNLQHSLH
RKLTVKQFLAKAAGRGELSLAFQPKVDLRSSRVIGCEVLLRWHSPILGQVSPAEFIPLAEEMGLIRELGEWVLRSALSQMVSWRERFGLAMPLAVNLSGM
QI-SADLPAWVAAELARHGIAPQLLTLELTETVLMVDMEGTRKVFEALGELGVNISIDDFGTGYSSLSYLNCLPINEIKLDRSFVVGL--N---LPVIRA
TAAMAASLGLDIIAEGVETDEELVELRAQGCHRIQGYLISHPLTAAELEAKGFMV-----
>tr|F6CT47|F6CT47_MARPP Diguanylate cyclase/phosphodiesterase OS=Marinomonas posidonica (strain CECT 7376 / NCIMB 14433 / IVIA-Po-181) GN=Mar181_2067 P
-------------------------------------------------------------------------------------LQNKMPSAAWVIDVE
HTIPMLNQAAESLLVNSLGPIQSGQ---R--QI-PLPLKQKWQSRLASCNKGQSFSCRWPFSSNLEQSHQCVGRAVQLPD--GRYGMLLEVRLEKT----
----QP-PSLVLQQFKTLFAIFSLDGQFINASDSFINHFGE-VSHI----NYLFAVSSAAKSFMS----RVNGLSNLSQEIMLSTVNGV---RWHRIEAS
FD--ANLGQIYLLAHDIQEERDHEVALYRLNNYDNLTNLPNRNLLYQQLESALQNAKKRDRQFGLMYLDLDGFKVVNDNFGHRVGDELIQRVAERIKSSI
PSGACLYRLGGDEFVVVLENTHDSELEDIAQSIMKNASNTYPVA-MEMMISASIGIASYPQHADDVDNLLKNADAAMYRAKSTGHNLYFVYENHMADNIN
AHLTLGGGLRKAIENEEFELHYQPKVALPDENVVGAEALIRWNHPDLGMVSPAKFIPLAEESGLILPLGEWVIRRACRQLQEWREKGYPAICLSVNLSSR
QFMQADLVDMVQAILEETGVDPAYLELELTESMLMTDAKQSIEKLHSFRKLGLTLSIDDFGTGYSSLSYLKKFPIQTLKIDRSFIHDIGIDSDNDAIVKA
TIAMAKSLNLKVIAEGVEHRSQVNALGGYDCQEVQGYLYSKPLPSDDFVQFMQKQ-----
>tr|A0A0D8ME71|A0A0D8ME71_PHOLE Diguanylate phosphodiesterase OS=Photobacterium leiognathi GN=UB42_03465 PE=4 SV=1
-------------------------------------------------------------------------------------PFNHLQSPIWIFDFD
HQIIWANDKALPLWESTHEELLSRD---LSKDM-SAAVEATLEEYRETFKQNKTIKTWWHLDPRKGKNLLCNFSGITLPD--GRIAMLVEVIGDES----
----LR-CELAFSDCANLALLFDEHGDLVSANNVFTKNYGNDLHNL----ASFVGDSDIAKQWIH----NARINQDLKHSRLCWTGQGH---IWFNIEAK
WL--ADKSQLLLQIVNITKEKENLQRERYNAEHDFLTGLMNRRGISSALKA----SHHFSLPYNLLFLDLDSFKLVNDTYGHAVGDKLLRAVAIRLLDTV
KCRGLVARFGGDEFIIQIEERNTNLE-LLTREIITTLNRPFYIKIGEISIGCSIGTAQYPKDADTFETLITQADMAMHCAKKHGRNCSYHFQPHLAETLY
RKNALRHHLSQALEIKDFQLYYQPIIDLSTMMLKGFEALIRWYDDSLGHVSPAEFIPLAEETGQIVPIGSWVLRKACEQLAEWNQKYDTKLIMSINLSRA
QL-KLSLVEELVLIIEEYNIDPSQIALEITESAMLQEFSEAKPCLDAIAALGFELYLDDFGTGYSSLSQLQNLPISTVKLDQSFVQNE--QDSGKAIVEA
TKAICNKLNLKVVAEGIETKQQLDYIQSCNFNYCQGYYFNKPLSVQDLENGILSS-----
>tr|A0A0D8NEX0|A0A0D8NEX0_PHOAN Diguanylate phosphodiesterase OS=Photobacterium angustum GN=UB35_01610 PE=4 SV=1
-------------------------------------------------------------------------------------PLNHLQSPIWIFDFD
HQIIWANDKALPLWESSHNELRSRD---LGKDM-SAAVEATLEEYRETFKQNKTVKTWWHLDPRKGKNLLCIFSGINLPD--NRVAMLVEVIGDES----
----IR-RELAFSDYSNLALLFNEQGNLVSANTVFTKTYGAELSNL----ASFVGDSDIAQQWIS----DAKNNLNLKHSRLCWTGKSH---IWFNIETK
WL--SDKSQLLLQVVNITKEKENLQRERYNAEHDFLTGLMNRRGISTTLKA----SHHSSLPYHLLFLDLDSFKLINDTYGHAVGDKLLRAVAIRLLDTI
RGRGLVARFGGDEFIIQVEDRYINLV-QLTQEIISALNSPFYIKIGEISIGCSIGTAQYPKDANSFETLITQADMAMHCAKKHGRNCSYHFQPHLAETLY
RKNALRHHLSQALEIKDFELYYQPIIDLNTMLLKGFEALIRWYDDSLGHVSPAEFIPLAEETGQIVPIGSWVLRNACKQLEKWNQQYDTKLIMSINLSRA
QL-KMSLLDELKAIIEEYNIDPAQVALEITESAMLQEFSEAMPCLDAIAALGFELYLDDFGTGYSSLSQLQNLPISTVKLDQSFVQND--HDSGKAIVEA
TKAICNKLNLKVVAEGVETKEQLEYIQSCNFNYCQGYYFNKPLSVSELEKGILST-----
>tr|A0A0B7JEC5|A0A0B7JEC5_PHOPO ANT-220, BDW_PPBDW_I_Contig_2, whole genome shotgun sequence OS=Photobacterium phosphoreum GN=PPBDW_I21729 PE=4 SV=1
-------------------------------------------------------------------------------------PLHYLQNPIWVFDVD
NKILWANDKSLRLWEATIEELLNRD---LGQDM-SAAAGATLVEYQQAFKLNKVIKTWWRFNPKKTKNMLCLFSGIPLDD--GRTAMLVEVIADES----
----LR-RDLAFSDCSNLALLFSSDGKFISANDAFSSSYGNHLVDL----SEFIGDINIAQQWLD----NAKKNNHFKCNSLCWTGQRH---HWFDIEAK
WL--CDNSQLLLQLVNVTKDKEKLNKEKYNAEHDFLTGLMNRRGVSAALKA----SHHRLSQYSLLFLDLDGFKLVNDTYGHAAGDKLLRAVAIRLLNVV
KDKGLVARFGGDEFIIQIERRNYTIA-NFSNQIIETLNRPFHIKIGELSISCSIGTSNYPDDANNFDTLVTQADMAMHRAKQRGRNCSYPFLQEMADALY
RKMTLRHHLSQALENQDFELYYQPIIDLSTQQLKGFEALIRWYDESLGQVSPAEFIPLAEETGQIVPLGLWILHSACQQLAYWTQLYKQTFIISINLSRA
QL-QPNLAQTIEQIINQYNVNPSQLALEITESAMLQDYCETKPCLDALAAMGIELYLDDFGTGYSSLSQLHDLPISTVKLDQSFVQGE--HTSSKVIIEA
TKAICEKLNLKIVAEGVETQAQLDYINQCGFDYCQGYFFSKPMPVHEIEQKYFHV-----
>tr|Q1Z3Y6|Q1Z3Y6_PHOPR Uncharacterized protein OS=Photobacterium profundum 3TCK GN=P3TCK_27959 PE=4 SV=1
-------------------------------------------------------------------------------------PFNHLQSPIWVFDID
NTIIWANLSALPLWEADLHELTSRD---LAHDM-SEAVEATLNGYRLRFNKDEIIKTWWNFTPKQLKKALCVFSGIKLPD--GRTAMLVEVIAEET----
----LQ-RALAFSDCSNLALLFNKEGILVSANNAFTLSFGKYLYDL----ANFLGDISSAESWLN----KAKIDGTIHNKKLCWTGQSH---LWFDVEGK
WL--KDEQQLLLHLTNISPEKEKLKKAKYNAEHDFLTDLLNRRGISNAINE----SNHQQQPYSLLFLDIDGFKMINDTYGHAIGDKLLKAIAIRLRETL
QHKGLLARFGGDEFIIQVEHRNVNTL-SFAKNIIAKLNKPFHLKVGELSIGCSIGTASYPDDADNIETLVTQADMAMHRAKLRGRNCSHHFSPDMAEALY
RKMILRHHLTLALEMEAFELYYQPIIDLKTRKLKGFEALIRWYDEELGQVSPAEFIPLAEETGQIVPLGKWIFKTAFLQLAAWQQKYDKAFMMSVNLSRA
QL-QASLAPTIEAMILRYNINPAQLALELTESTMLQEYDDAKQCLEDLAALGIELYLDDFGTGYSSLSQLQDLPISTVKLDQSFVQGN--HKGSRAIIEA
TKAICEKLDLKVVAEGVETIEQLQYLQMCNFDYCQGYYLAKPMPAHQLEESGFAL-----
>tr|L7NJQ6|L7NJQ6_PHODP Uncharacterized protein OS=Photobacterium damsela subsp. piscicida GN=PDP_0267 PE=4 SV=1
-------------------------------------------------------------------------------------LFNNLQCPVWIFDID
NKIIWANEKSLPLWEAKLSELTNRD---LSFDM-SAAVEATLVDYKATFARGKTIKTWWSFTPHELKKYLCIFSGIPLSD--GRMGMLIEVLANET----
----LR-RDLAFSECSNLALLFNQSGQLVSTNAAFSHQFGECVNDL----ASFIGDITQARQLLE----NAQQNRIVDQKLLCWTGQRH---LWFHIEGK
WL--EEQQQLLLQLTNISPEREKLRQAKYNSEHDFLTGLMNRRGISSAIKI----SHHTKQPYSLLFLDLDGFKMINDTYGHAVGDRLLRAVSIRLRQVI
QHRGLLARFGGDEFLIHVERRNITPC-AFAKEVITALNKPFHLKVGELSIGCTVGTTNYPEDAQDIDTLVTQADMAMHRAKLRGRNCCHHFSPDMADALY
RKMILRHHLTLALNANAFELYYQPIVDLKKAKLKGFEALIRWNDDDLGQISPAEFIPLAEETGQIVPLGQWILKTACRQLAEWKKKYDHSFIMSVNLSRA
QL-QTGLVQSVKACLDAYQIDPKQLALELTESTMLQDYSDAKQCLTELAELGIELYLDDFGTGYSSLSQLQDLPISTVKLDRSFVQGE--HKGSQAIIEA
TQAICEKLDLKVVAEGVETEQQLDYLRQCNFDYCQGYYLGHPMPPQTIEDRQFSL-----
>tr|L8JIZ6|L8JIZ6_9GAMM Diguanylate cyclase OS=Photobacterium sp. AK15 GN=C942_01403 PE=4 SV=1
-------------------------------------------------------------------------------------LFNRLQSPVWVYDLH
QKIIWANSASLPLWETDVEELTARD---LGADM-SEAVSAMLDNYQESFQQGKAIKTWWFFSPNNLKKALCHFSGIPLSD--GRTAMLVEVVSEES----
----LR-RDLAFSGCSNLALLFSAEGDLISANNAFSHSFGAHLNDL----ASFLGDLNQSHNWIN----EARQRGTIHHKKLCWTGKSH---YWFDIDGK
WL--QDKEQLLLNLVNISQEKEQLHTAKYNAEHDFLTGLLNRRGISDAITE----NQHEQQHYSLFFLDIDGFKLVNDTYGHAIGDKLLRAIAIRLQECV
KFKGLLARFGGDEFIIQVEQRNVDPA-VFAKNIIAALNKPFHLKVGELSIGCSIGISSFPDDAKDIETLITQADMAMHRAKLRGRNRSHRFSPDMADALY
RKMTLRHHMTMALEEDAFELYYQPIIDLKKRDLKGFEALIRWHNEELGHVSPAEFIPLAEETGQIVPLGHWILKTACKQLADWRKKYDQNFVMSINLSRA
QL-QSSLAHSIEQVIQENDIDPKQLALELTESTMLQEHDEAKQCLKDLDALGIELYLDDFGTGYSSLSQLQDLPISTVKLDRSFVQGE--HKGSQAIIEA
TQAICEKLDLKVVAEGVETLSQLKYLQACNFDFCQGFYLGRPLPSYELEARNFSL-----
>tr|A0A0C5WQD7|A0A0C5WQD7_9GAMM Uncharacterized protein OS=Photobacterium gaetbulicola Gung47 GN=H744_2c2697 PE=4 SV=1
-------------------------------------------------------------------------------------LLEFLQIPVWIFDIH
QRILWANSAALPLWEAKTDELTARD---LSLDM-SEAVDAILDGYLSRFQQGEKIKTWWYFSPNDIKKALCYFSGMPGPD--GNTVMLVEVIAEES----
----LR-RELAFSGSSNLALLFDESGHLISANNSFTHSFGEDLKDL----ASFLGDAQLADKWLA----AARHEGILKAKRLCWTGKSH---HWLNIDGK
WL--TDKHQLLLSLINISQEKEQLHKAKYNAEHDFLTGLLNRRGITNAIVE----NQHSQHPYSLLFLDIDGFKLVNDTYGHAIGDKLLRAIAIRLQEEV
KFKGLLARFGGDEFIVQAEHRNINSA-MFAKQLIKALNRPFHLKVGELSIGCSIGTSDYPSDAKDIETLVTQADMAMHRAKLRGRNRSHHFSPDMADALY
RKMTLRHHLTLALEADAFELYYQPIVDIKSKSLKGFEALIRWHDEELGQVSPGEFIPLAEETGQIVPLGKWILKTACKQLALWREKYGKAFIMSVNLSRA
QL-QSSLAPTIEGLLNRYQIPPSQLALELTESTMLQEYDEAKQCLDDLASLGIELYLDDFGTGYSSLSQLQDLPISTVKLDQSFVQGE--HKGSQAIIEA
TQAICEKLALKVVAEGVETEAQLRYLQQCRFDFCQGYYLGRPMPAHEHEDRNFSL-----
>tr|B7VSG4|B7VSG4_VIBTL Vibrio splendidus LGP32 chromosome 2 OS=Vibrio tasmaniensis (strain LGP32) GN=VS_II1184 PE=4 SV=1
-------------------------------------------------------------------------------------PFEHLKCPIWIYDID
NRITWANSSALPLWESELFELTSRD---FGVEM-SKAIEATLEEYQRQFQRNQSVKTWWNFTPKYSKRALCLFSGIPLPD--GRTGMLAQVIAEES----
----LK-RDLTYSDGSNLSLLFNKVGSVVSANSAFSKNYGSPFSRL----SDFVSSEEVADQWLF----SARKGRDILEEVSCKIENKT---HHFDVHGK
WL--FDKSELLLNLTCTTKQKENLIKARYNAEHDCLTELYNRRGITKRLES----SIACRSPFELMFVDLDGFKLVNDTYGHSVGDQLLKKVGKRLKQIL
DETCTIGRFGGDEFIVIAHARKNNIP-LLCSRIIDSLNKSFQIKIGTLSVGCSIGSAHFPDNATDKESLLKQAGMAMHVAKANGRNRFQTFTPNLAQILH
RQVEIRHRLTLALEGDDLNLHYQPIMDTNSNKVKGFEALLRWSDKDLGNIEPDEFISLAEETGQIVPLGKWVLNSALKQLSIWHRKFDDELVMSINISCI
QM-HTTFAEQLSAMLNFYNIQPKSIALEITESSMIFKHGEVRQALDDISALGVELHLDDFGTGYSSLSMLHDLPISTVKLDKSFVHGT--YKGSEAIVQA
TYAICEKLGLMVVAEGVETETQKAFLTSCGYQYLQGFLFSKPIPPDEVEMRFLSS-----
>tr|A0A066UQD4|A0A066UQD4_9VIBR Diguanylate phosphodiesterase OS=Vibrio fortis GN=VFDL14_13890 PE=4 SV=1
-------------------------------------------------------------------------------------PFEHLKCPIWVYDID
NLIVWSNSSALPLWEADIQELTSRD---LGKEM-SEAIEATLEEYQRQFHLNQTIKTWWNFTPKHAKRALCQFSGIPLPD--GRTGMLVQVVAEES----
----LK-HDLACSDGSNLSLLFDKTGEILSVNTAFYQSYGKPFTQL----IDFLGDEETVDLWLF----SAMRGQEILEEVSCQIGDKT---HYFDVQGK
WL--FDKNQLLLNLTCITRQKERLLLAKYNAEHDCLTELHNRRGITNLLQT----SIEYRSPFELMFVDLDGFKLVNDTYGHNVGDQLLKQVGIRLKELV
DDTCMIGRFGGDEFIVIAHTCRNNIP-LLCSRIINALNKSFHIAIGSLSVGCSIGTAHFPDNAMDQESLLKQAGMAMHMAKANGRNRFQTFTPDLAKALH
RKVNIRHRLAGAIENDDLKLHYQPIIHSDSNKIKGFEALLRWKDHELGEIAPREFISLAEETGQIVPLGRWVLNAALKQLATWHKKYGPELTLSINISGK
QI-HSAFADQLSAMLKFYQLPANKVALEITESSMIFKHGEVEQALYDIAALGVELHLDDFGTGYSSLSMLHDLPISTVKLDKSFVHGS--HQGSKAIVKA
THAICEKLELKVVAEGVETESQKQFLMNCGYQYFQGFLFSKPIHPDEVEEYFLSP-----
>tr|F9SG22|F9SG22_VIBSP Uncharacterized protein OS=Vibrio splendidus ATCC 33789 GN=VISP3789_18834 PE=4 SV=1
-------------------------------------------------------------------------------------SFEYLKYPIWIYDID
NRITWANQSALPLWEAELFELTSRD---FSVEM-SKAIEATLEEYQRQFLRGESIKTWWNFTPKYAKRALCQFSGIPLPD--ARTGMLVQVVAEES----
----LK-HDLAYSDGANLSLLFDRSGKIVITNSAFNQNYGSPFTTL----SDFLSSEETAAHWLF----SARTGQEILEEVSCTIGDKT---HHFDVQGK
WL--FDKSELLLDLTCTTKQKEKLIKARYNAEHDCLTELHNRRGITNLLQT----SIAYRSPFELMFVDLDGFKLVNDTYGHSVGDQLLKQVGERLKQLV
DETCMIGRFGGDEFIVIAHACRNNIP-LLCTRIIDALNRSFHISIGTLSVGCSIGTANFPDNAIDQESLLKQAGMAMHMAKANGRNRFQTFTPSLARALH
RKVEIRHRLARALENEALALHYQPIMNTSSDKVKGFEALLRWSDKDLGDIRPDEFIALAEETGQIVPLGKWVLNSALKQLSIWHREFDNKLMMSINISSI
QM-HATFADQLSAMLNFYNIQPQSIALEITESSMIFKHGEVRQALCDIAKLGVELHLDDFGTGYSSLSMLHDLPISTVKLDKSFVHGS--HKGSKAIVQA
TQAICDKLGLKVVAEGVETEMQKDFLVDCGYQYLQGFLFSKPIPSNEVESKFLFL-----
>tr|A5KX05|A5KX05_VIBBS Uncharacterized protein OS=Vibrionales bacterium (strain SWAT-3) GN=VSWAT3_26681 PE=4 SV=1
-------------------------------------------------------------------------------------SFEYLKCPIWIYDID
NRITWANRSALPLWEAELFELTSRD---FSIEM-SKAIEATLEEYQRQFVRSESIKTWWNFTPKYAKRALCQFSGIPLPD--GRTGMLVQVVAEES----
----LK-HDLACSDGANLSLLFDRSGNVVSANSAFSQAYGSPFTTL----SEFVSSQETADQWLF----SAHKGREILEEVSCHIGNKT---HHFDVQGK
WL--FDKSQLLLNLTCTTKQKEKLIKARYHAEHDCLTELYNRRGITNLLET----SIAYRSPFELMFVDLDGFKLVNDTYGHSVGDQLLKQVGERLKQLI
NETCMIGRFGGDEFIVIAHSCRNNIP-LLCTRIIDAINQSFHISIGSLSVGCSIGTAHFPDNAMDQESLLKQAGMAMHTAKDNGRNRFQTFTPSLAQALH
RKVEIRHRLTQALESEALALHYQPIMDTCGDKVKGFEALLRWSDKDLGMIEPDEFIALAEETGQIVPLGKWVLNSALKQLALWHREFDSQLMMSINISGS
QM-HATFAEQLSAMLNFYHIQPKNIALEITESSMLFKHGEVRQALTDISKLGVELHLDDFGTGYSSLSMLHDLPISTVKLDKSFVHGS--HKGSKAIVQA
TRAICDKLGLKVVAEGVETETQKEFLIDSGYHYLQGFLFSEPIPSNEVESQFLFL-----
>tr|A3USL6|A3USL6_VIBSP Uncharacterized protein OS=Vibrio splendidus 12B01 GN=V12B01_11050 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------MFELTSRD---FSVEM-SKAIEATLEEYQRQFLRNESIKTWWNFTPNYSKRALCLFSGIPLPD--GRTGMLVQVIAEES----
----LK-HDLACSDGANLSLLFDNSGNVVSANSAFFQNYGSPFSTL----SDFVSSEETAAQWLF----AARKGREILEEVSCEIDNKT---HHFDVQGK
WL--FDKSELLLNLTCTTKQKEKLIKARYNAEHDCLTELYNRRGITNLLET----SIAYRSPFELMFVDLDGFKLVNDTYGHSVGDQLLKQVGERLKHLV
DETCMIGRFGGDEFIVIAHACRNNIP-LLCSRIIEALNKSFHIRIGTLSVGCSIGTAHFPDNAVDQESLLKQAGMAMHMAKANGRNRFQTFTPCLAQTLH
RKVEIRHRLTHALENDDLNLHYQPIMNTNSDKVKGFEALLRWSDEELGDIAPDEFISLAEESGQIVPLGKWVLNSALKQLSMWQREFDNELMMSINISSI
QM-HATFAEQLSAMLNFYNIQPQSVALEITESSMIFKHGEVRQALSDISKLGVELHLDDFGTGYSSLSMLHDLPISTVKLDKSFVHGS--HKGSKAIVQA
THAICDKLGLKVVAEGVETETQKAFLIDCGYQYLQGFLFSKPIPSNEVERQFLTG-----
>tr|U4KFA6|U4KFA6_9VIBR Putative Diguanylate cyclase/phosphodiesterase OS=Vibrio nigripulchritudo GN=VIBNI_A1573 PE=4 SV=1
-------------------------------------------------------------------------------------DFELLHNPIWIFDLD
SQIVWANSPALVLWESDLDELKKRN---LRSSM-SMAVEATLEQYRKKFNNNEKVRTWWSFTPKRLKCALCVFSGIEITP--GKTAMLVEVVAERS----
----LK-RDLAFSGGGSLSLLFDHKGNLVSANEAFRLTFATSFYTL----GDLLSSKIRAFEWLE----SAPMKQEIKEEISYDMDGKP---HHFDVTAQ
WL--FDKNQLLLTLVDITEKKQRLEEASFNACHDYLTGLYNRRGMLDVISE----HTIQQIPFTLAFLDLDGFKLINDTYGHEVGDELLKAVTQRLKQCV
PDGCILGRFGGDEFVLLFPQKGLQVS-STLGQIIHLVANHYPINIGDLSITASMGASHYPTNSQDVETLIKQSGMAMHQAKNEGRNRFELFSPTLSSTLN
RKVLVRQRLSHAIERKAFTLVFQPILETQSDTMVGVEALLRWEDEKLGNVPPEEFIPLAEETGQIIEIGNWVLNEACKTLAEWKHVLPENFTMSVNISQI
QV-NNSLSKQLETMLNYYQIPSTRLALELTESAMVLKHEECGKWLNDIVDLGVRIYLDDFGTGYSSLSVLDALPISTIKLDKSFIHKC--HKGSETIIKA
TVSLCNALGMTLIAEDIETEEQLSMIESHGCRYVQGFLRSYPLPKHTLESRYLNA-----
>tr|F9RQB8|F9RQB8_9VIBR Uncharacterized protein OS=Vibrio scophthalmi LMG 19158 GN=VIS19158_13337 PE=4 SV=1
-------------------------------------------------------------------------------------AFEQIQSPIWIYDFD
HAILWANHAALTLWESPLAELTDRD---LTIGM-SQAIESTLESYRRTFEQGECIRKWWNLTPKNHKRVLCDLSGITLDD--GRIAMFCHALSEEC----
----LR-TSLAFSDSANLSLLFDLSGNLLSANEAFQHRYHLLLQHL----STLTGSDQRANKWLT----EVQAKGEIEKESTLAIGSQS---CTFRVFAT
WL--KKNQQILVELIDITKQKNQILTAQFEASHDCLTGLYNRRGLLEQATS----WSQTDHSFHLIFIDLDGFKMINDTYGHGQGDSLLISVGRRLQQSL
TDALALARFGGDEFVALLPTHS-DIT-SRLSDINRFLRRPYTLDSMTVAVNASIGCSTFESGALHVETLIQYADFAMHKAKEQGKNRYQVFTPDLAQAML
RKFLIRQHLARALENNQFTLYFQPILCSQTNNVCGAEALLRWHDQALGNIPPAEFIPIAEESGQIVALGDWVLNQAIKQLSVWQTKFEQPFVISINVSRV
QL-HRAFCEQLNQRLNSYRVSPHQVAIELTESCMVYKMEDVKQWLTDVSQLGVKIYLDDFGTGYSSLSVLQQLPIDLVKLDKSFVQSS--HESGLAIIQA
TSAICEKLGLTMLAEGIEQPEQHEVVCQNNYAYLQGYLLGRPIPAHEFEQRYLTA-----
>tr|K1J1K6|K1J1K6_9GAMM Diguanylate cyclase (GGDEF) domain-containing protein OS=Aeromonas veronii AMC35 GN=HMPREF1170_02094 PE=4 SV=1
-------------------------------------------------------------------------------------TMDVLHTPIWVYDIE
HHIFWANSAALSVWEATLDELCSRD---FSADM-ATAIDLLLQRYLGDFQQGRSYNEWWTLSPKGKKQIYLRLSGIQLA---GRLMMMTEAVLDST----
----LY-QESSLATGDTLACLFDSHGVFESGNYHFEMCFGHQIAKL----SQVFSGNDDS--FYQ----KLSRLDEVVTEGECRTLKGM---RWFQYQFR
YI--QQGARILLTMRDITDRKLEELEHRHLAWHDSLTGLLNRYGLMKSLEA----YCGLGERFALVFMDLDNFKLVNDNYGHKAGDRLLERVAGRLKQIC
PRDVELARLGGDEFTALVPLGNQDRAQEVADQMLSQMTKPLQLSLPEVTIGGSIGIAIYPDDADDGDNLITRADMAMYQAKQMGRLRWQRFTPSMQQTLQ
RKLNLKQFLAKAIGRQELSLCYQPQVDAAKRRLIGYEALLRWYNPVLGHVSPVEFIPLAEEMGLIREIGSWVLSTALAQVASWQKRFHQRVPVSVNLSGF
QL-SSALPGQVRQQLELHGVDASLLTLELTETVLMLDMKGCLGILDDLSEQGIKIAIDDFGTGYSSLAYLNRLPINNIKLDRSFVVGL--N---LPVIRA
TAAMATNLGLGIMAEGVEEPHELAALQTQGCHVFQGYLFSKPLTVAQVEASGFVV-----
>tr|K1JFY6|K1JFY6_AERHY Diguanylate cyclase (GGDEF) domain-containing protein OS=Aeromonas hydrophila SSU GN=HMPREF1171_00897 PE=4 SV=1
-------------------------------------------------------------------------------------GMDVLHTPIWVYDIR
HHIYWANRAALNVWEASLDELQSRD---FSADM-AQAIDLLLQRYLGDFQQGRSYSEWWTLSPKGKKQVYLRLSGIQLA---GRLMMMTEAVIDAT----
----LY-QESSLATGDTLACLFDNLGRLESGNHQFEMCFGDEVHHL----SQLFSGNDDA--FYQ----KLSRLDEVVAEGECRTLKGM---RWFQYQFR
HI--QQGAQILLTMRDITDRKLEELEHRHLAWHDSLTGLLNRYGLMKSLEA----YCGLGGRFALVFMDLDNFKLVNDNYGHKAGDRLLERVAGRLKQIC
PRDVELARLGGDEFTALVPLSHSDRAQEVADLMLSQMTKPLQLSVPEVTIGGSIGIAIYPDDADDGDNLITRADMAMYQAKQMGRLRWQRFTPSMQQTLH
RKLTLKQFLAKAIGRGELSLCYQPQVDVAKGRLLGYEALLRWHNPVLGHVSPVEFIPLAEEMGLIREIGGWVLSTALAQMAHWQKEWRVSVPVSVNLSGF
QL-SSSLPELVAQQLKEFGVDAGLLTLELTETVLMLDMKGCIEILDGLSEQGIKIAIDDFGTGYSSLAYLNRLPIDTIKLDRSFVVGL--N---LPVIRA
TVAMATSLGLGIMAEGVEDEHELAALRTQGCHVFQGFLFSKPMSVAQVEESGFVV-----
>tr|V9ZVU5|V9ZVU5_AERHY PAS/GGDEF domain-containing protein OS=Aeromonas hydrophila 4AK4 GN=AH4AK4_2357 PE=4 SV=1
-------------------------------------------------------------------------------------AMDVLHTPIWVYDIQ
RHIYWANGSALGLWEASLAELQSRD---FSADM-AAAIDLLLQRYLGDFQQDRSYNEWWTLSPKGKKQVYLRLSGIQLA---GRQMMMTEAVIDAT----
----LY-QESSLATGDTLACLFDNQGCLESGNHHFDMCFGTGITRL----AQVFSGDDGA--FYT----RLSRVGEVVAEGECRTQKGM---RWFQYQFR
HI--QQGARILLTMRDITDRKLEELEHRHLAWHDSLTGLLNRYGLMKSLEA----YCGLGGRFALVFMDLDNFKLVNDNYGHKAGDRLLERVAGRLKQIC
PRDVELARLGGDEFTALVPLSQAERAQEVADLMLSQMSKPLQLSVPEVTIGGSIGIAIYPDDADDGDNLITRADMAMYQAKQMGRLRWQRFTPSMQQSLH
RKLTLKQFLAKAVGRGELSLRYQPQVDVAQGKLIGLEALLRWYNPVLGHVSPAEFIPLAEEMGLIREIGSWVLATALAQMGEWQRQWQVRVPVSVNLSGF
QL-SASLPGQVAQQLRESGVEAGLLTLELTETVLMLDMKGCIEILDALSEQGIKIAIDDFGTGYSSLAYLNRLPIDTIKLDRSFVVGL--N---LPVIRA
TVAMATSLGLGILAEGVEDEHELAALRAQGCHVFQGFLFSTPMTPEEVAAAGFGI-----
>tr|A6VW49|A6VW49_MARMS Diguanylate cyclase/phosphodiesterase OS=Marinomonas sp. (strain MWYL1) GN=Mmwyl1_1752 PE=4 SV=1
-------------------------------------------------------------------------------------LHRKMPLAAWIIDIE
QSVPWCNEAAEVLLMDSLSDIKSGQ---R--VI-GAELKNRLSLYLETLDVGKTLPFKWPFVSKDGIHYNVLGTVISLGG--ARKGLSVEAH--PS----
----LP-RVSVESHFTTLFAVFEQSGIYLEASKCFTEQFGD-IEHV----RDLFAVAGAANSFIG----RLAQRESLSQEIRLSTKNGV---RWHKIEVS
HQ--PMTNVVYLLTHDIQEERDHEVALYRLNNYDGLTHLPNRNLLYQQLESALVNARKRHRQFGLLYLDLDGFKVINDNFGHRVGDELIQRVAERIKGSI
PSSACLYRLGGDEFVVVLENTNEEELESIAQSIMQNASNTYPVA-MEMMITASIGIASYPQHADDVDNLLKNADAAMYRAKSTGHNMYCVYEDHMADNIN
AHLTLGGGLRKAIEEEQFILHYQPKIRLPDEIVVGAEALIRWVHPELGMISPDQFIPLAEESGLILPLGEWVIRRACRQLQEWREAGLDPIKLSVNLSSR
QFMQADLVDMVQRALEETGVDPEYLELELTESMLMADAQQSIEKLHSFRKLGLTLSIDDFGTGYSSLAYLKKFPIQTLKIDRSFIHDLGLDCDNDAIVKA
TIAMANSLNLKVIAEGVENRSQVDVLNGYDCQEVQGYLFSKPLSSDDFLMYLKAH-----
>tr|W1RXJ1|W1RXJ1_9GAMM Diguanylate cyclase OS=Marinomonas profundimaris GN=D104_03335 PE=4 SV=1
-------------------------------------------------------------------------------------LQCKMPLAAWIIDVE
HSVPWCNDAAEQLLVDSLGEIHSGR---R--II-SDTLKERLSLCLGAVEEGKTLAFNWPFISKNGTRYNCTGSVISLGD--ERKGLSVEAR--PV----
----LP-SAPQHRQFKTLFVIFDMDCVCVESSDAFKTHFGD-IRHV----RDLFAVSGAANSFIS----RISKQENLSQEIMLSALDGV---RWHRIEVS
KN--ALTNKIYLLAHDIQEERDHEVALYRLNNYDSLTNLPNRNLLYQQLESALINARKRQREFGILYLDLDGFKVINDNFGHRVGDELIQRVAERIKASI
PSGACLYRLGGDEFVVVLENTHAEELENIATSIMQNASNTYPVA-MEMMITASIGIASYPSHADDVDNLLKNADAAMYRAKSTGHNLYFVYENKMADNIN
AHLTLGGGLRKAIDEEEFVLHYQPKIRLPDEAVVGAEALIRWLHPELGMISPDQFIPLAEESGLILPLGEWVIRRACRQLQAWREAGYPPIKLSVNLSSR
QFMQADLVDMVQRILQETGVDSEYLELELTESMLMADAQQSIEKLHGFRKLGLTLSIDDFGTGYSSLAYLKKFPIQTLKIDRSFIHDLGLDSDNDAIVKA
TVAMANSLNLKVIAEGVESRAQVDVLNSYKCQEVQGYLFSKPLCSHEFALYMDTH-----
>tr|A3YDP2|A3YDP2_9GAMM Putative sensory box/GGDEF family protein OS=Marinomonas sp. MED121 GN=MED121_23259 PE=4 SV=1
-------------------------------------------------------------------------------------PKELAKAPEWVIDVD
HSIAWYNQAASVLFFESGLNKECKN---L--SI-SVALRRRLINFLRALEKGPAKPISWTFLSVKGQYYDCYANIVLLGP--KTYGIKVKAIKRHL----
----LR-TQPRVGEFSHLLAVFDDKQNLVDASPLFHDTFVG-LVHL----KEIFALNSDLNKILE----FIARVTTQSWELRLSTNQGV---RWHKLEVS
YD--RRQSKSYVSLLDVHKLREQENALFKLKNYDALTDLPNRHLLYQELDLTLQTAQNNLTQFGVLYLDLDGFKVVNDSFGHRVGDELIVQVAKRLMTAL
PKGGRLFRLGGDEFALLQEGVTQEELEVLAQNLMQVACAAYPIA-MEMLITASIGIAHYPTHAQDVDSLLKLADVAMYRAKSIGHNSYKVYDSNMSQSLN
AYLTLGGGLRRAIEKQEFELYYQPKINLLDQTTVGAEALIRWRHPEFGMISPDRFIPIAEETGLILPLGEWVIRTACKQLQEWRELGFPDMTVSVNLSGR
QFMQADLVNMVHQVLIETGINPKNLELELTESMLMADADQTIEKLHGFRELGLSLSIDDFGTGYSSLAYLKKFPIQTLKIDRSFVRDLSSDLDDNAIVKA
TIVMASSLNLKVIAEGVETHTQLDVLKGYQCQEVQGFFFSKPMPRQEFNLYIARD-----
>tr|F2JVU0|F2JVU0_MARM1 Diguanylate cyclase/phosphodiesterase OS=Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1) GN=Mar
-------------------------------------------------------------------------------------NTESREAARWLIDVS
KSICWSNRSAKALFSTEISKD-------R--LL-NSQLKNALIDKLTSLSPEREENLCWVIKCQDGRVLQCIGHRVHLGP--GHLGVKVEAREMTL----
----VD-MGSGQLDAFNLYFRFDITGKCLRQSAQALTQFEN-VEEF----KDLFAVSAMAPSVFG----QLLTKGRISTDVRFLTKTGI---HWCHIEGY
KE--SAGDSFYLQVTDKQDIRLAEAELYRLKNYDSLTRLPNRESLYLKLDSQIAKVAQKDQSFGLLFIDLDGFKTVNDSFGHQVGDELLCGVARRIQGVL
PRNTQLFRLGGDEFAILVEDILNSNLIEVAQDVVSVSAQPYPVE-LEMLVTASVGISKYPDHGKSIDDLLKTSASAMCRSKALGYNNFCLYDNGMKQDYR
AQLTLGGALRKAIEEEQFELYYQPKIRLSDELTVGAEALIRWIHPEHGMIPPDKFIPIAEETGLILPLGEWVIKRACHQLKEWREAGHPPISLSVNLSGR
QFMQSDLVEMVRATLAETGVDPKYLELELTESMLMADAQQTIEKLHGFRKLGLTLSIDDFGTGYSSLAYLKKFPIQTLKIDRSFVSDLGIDADDDAIVKA
TIAMANSLNLKVIAEGVESRSQIDVLNDYQCEEVQGYLFAKPMNNIDFSSYLSAQ-----
>tr|A1SFR9|A1SFR9_NOCSJ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Nocardioides sp. (strain BAA-499 / JS614) GN=Noca_1138 PE=4 SV=
---------------------------------------------------------------------------------------QRASDLAVVLDPD
ATVLFASPAMTGVLGHAIEDVLAND---AMDYVHPDDVERARAVLAEVVGAGGSVGTTTRLRDHRGTWHWMELTATNLLDTSVGGVVC--NLRDVTDRVR
AEAALRASEAIADNADEGLWVTAPDGRSAYVNQRLVEILGLEAEEILGRPVEVLDPH------EQPMTRVLAAGGTQRHEVTYRHPDGGRRSLVVSTSPL
DDAGGAVEGSLAMVADVTDARRLERELRDAALHDGLTGLPNRALLRDRLEHALARETRS---TAALLIDLDRFRVVNESRGHAAGDTLLADTAHRLAAAV
RPTDTVARFGGDQFLVICEDVDEQEARAIGEDALGALRPPFPAGGGDVTLTASAGLALTPA--PSAGALVRRAETALRAAKAAGGARVQAYDAEAAAVSE
QRFELGVELARSLAADELALHYQPVIGLASGEVVGVEALCRWQHPLLGQVPPSTFIEIAEAEGLAATLDRWVVERALREAAELRASGALPAYVAVNVSAR
SLADPGLAEHVLRAAQTAGTAPQDVLLEVTESATMTDPAAAADLLGRLRRHGFRVAVDDFGTGHSSLAYLRRLPVSVLKVDRSFVAEVATDEHARAITGS
IVDLARTMGLSVVAEGVETPAHAAVLRRLGADAGQGWLWSPAVSPEEATRTGAL------
>tr|T2GFF6|T2GFF6_DESGI Putative diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio gigas DSM 1382 = ATCC 19364 GN=DGI_3153 
---------------------------------------------------------------------------------------LRQANLVVELSPV
LLLVWHISQNITLLGHSAKALLAAG---AASLMPPEDVAALRQEVQRAAEDSDKFALDCRLRCSDGTIKWMETRITLLPPRPGLPARC--QMLDVTSRKL
AESRMLQQKQLFENSPQAIVICDRDGNVSGVNRAFEKMFGYEFTELWNKRLPFLAPQ------AEEMTRRLSQGAA---ETIRRRKDGQIVHVYMLSFP-
IIINDEMEGAYRIFLDITERKRAEEQLVFHSFHDKLTGLPNRALLLDRLRRAMERAKRHGRRYALLYVDLDRFKLVNDSLGHAAGDQLIQITSQRIARLL
QPIDTVSRLGGDEFCVLLDSVYSREDERVARELLQEVEEPVELLHRRLQFTASIGIAMGDLQVDNEEMLLRDADIAMSMAKERGKNTYVVFDPSMRSRVQ
DAMRLETELRRAIAQEEIVAHYQPIVSVADNVLLGFEALARWRHPERGLIFPGEFIELAEETGLIVNLGRQILSAALQDLASWCTVHPASLTMSVNLSAR
QFMQSDLVEQVRQAVRASGMPAQCLCLELTESVVMENAASARVLLERLKALQVRLAVDDFGTGYSSLAYLHQFPLDSLKVDRSFVQRLGRQDSDNAIVHA
IIQLAQALRLRVVAEGVEEVAQLEVLQSLGCDAAQGYLLGKPMPAEAVLRLLAG------
>tr|N6VYE1|N6VYE1_9ALTE Diguanylate cyclase/phosphodiesterase OS=Marinobacter nanhaiticus D15-8W GN=J057_15890 PE=4 SV=1
---------------------------------------------------------------------------------------LSQHEAVVSLDAA
SRVLY-SDGAERLFGLRLDDVAGRQ---VASYLDQVR-----------AGD-ETVKTEIEVSGLQG-VAQVEAVISKVREDSGALIGF--SLRDVTERNR
ALKAERYQRSALSSSLDQVYVLDLDGRFLYANQALADQLELDLDWVIGKKTDLTVRQ------IWDIQQVI---DSVRSEVPFTAASGKRWVFDYIFVPV
LDEQGRIEAVAGKTRDITEHRETSERVWKEANYDSLTQLPNRRLFRDRLELEVKHAERNGASLALFFIDLDRFKEVNDLYGHGAGDELLREAATRIHSCV
RESDTVARLGGDEFTVILTELDDEHVERTAQKILDELARPFRVQENICHVSGSVGITLYPSDAVEPADLIRNADQAMYNAKNSGRSQFSFFTRSLQDEAL
TRLRLMTDLRHAVSEKQLRVYFQPIVRLADSAIVKAEALVRWEHPARGLLLPNEFIQLAEESGQIKRLGNWVFTQAAQWSKRWSQL--LRFQISINKSPV
QFEGRGHKMNWAAHLKEKGMAGNSISVEITEGVILNATATTSDKLLELQEAGMELAIDDFGTGYSSMAYLKKFDVDYLKIDMSFVQDMASNASSRTIAES
IIVMGHKLGLKVVAEGVETEDQREWLRSAGCDYAQGFLFSKPLTPEAFEACLKS------
>tr|F2F9H5|F2F9H5_SOLSS Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Solibacillus silvestris (strai
------------------------------------------------------------------------------------EPLLDTPFPSFVLSPN
GTLVHENISRFDYISKETKGLIGK-------SIHDTLFSEVGDDVIETILTGVALCHNIPLSLKGQSSKICTLYTKPTVFNEQAISVLCIPNEEVRLMDE
EQQHLV---DLKNGIHQSTVTLDQDGFITQTNQQFLTASHWTPKRVIGKTLWQLFPQNESEKVVLEIWKTLQNGQVWQGEVEQLTKDEQLYWVHLTAIPM
MGQTSEKNEYMLIERNITKEKKIQFQLEKIAYIDTETGMMNVHRLEQIIGEMIE----EDRHFSFVYLSIDKFYTIKDLHDGVAGNSLIVDFTKRMKMYF
-QDSTMARINESEFVVITPLPE-----WFTQGFLYLQQNPIYSGNVAVPLSLSGGITRFPEDQMTFSQLMKASLATIASVRSAGGDSIVSLSKSSHAALN
RRSIVEKRLLLALDQKNLHVLYQPQVDLKSGNITAVEALVRWDDEEIGAVSPDELIPIAEETGLINNIGSFMLEKACEQAVLWKNAGHA-IKVSINSSVR
EFRDKNMAKSILETLDRTGCPANLLQIEITEKFALEAETGIIKQMRALEKEGIVFVLDDFGTGYGSFRYMQLLPISILKIDQTFIHSL-KSKKNQQLVNG
MVQLGKSMNLTVVAEGVETEEQMQFLTSIGCDFIQGYFVSKPSSTEEISSLL--------
>tr|A0A0A3IM48|A0A0A3IM48_9BACI Diguanylate cyclase OS=Lysinibacillus odysseyi 34hs-1 = NBRC 100172 GN=CD32_08355 PE=4 SV=1
------------------------------------------------------------------------------------ELLEQTPFPSFIISRQ
GKVLKWSALGRHYFGYEADDFIKG-------SVSDYLFASLPKDVQEAIFTSQSIQNHLHLLSKKEELIEASLLTRPCRYEEEAIFVMTVPQQDVVTADD
QQQELI---NLQNGIQSSTVTLDYEGFIIGCNQQFLKASHWTPKRVLGKTFWKLFPENESAKLTQTIWRTMNNGHIWQGEVEKATKDGQTYWVHLTAIPT
LGLTKEKTRFTLIEKDITKDKIIQLQLEKIAYIDTETGLMNIHRLEKIINDMIG----AKRHFSFVYLSIDKFYTLKDLHESEIDSGLIVEFTKRMKMYF
-QDSTMARINEHEFVVITPLPE-----WFTQGFLYLQQHPIYNQNVAVPLSVSGGITRYPEDQSTFTQLMKASLATIASVREAGGDSIVSLSKTTHKALN
RKAVIEKRLLLALDQKNLKVLYQPQLDLKTGNITAVEALVRWEDEEIGVVAPDELIPIAEETGLINRIGSFMLERACEQAVEWRNAGIN-LKVSINSSVR
EFRDKNMAKSILDTLAKTNCPPSLLQIEITEKFALEAETSIIKQMRQLENEGITFALDDFGTGYASFRYMQLLPIEILKIDQTFISSLLQSEKTQRLIDG
MVKFGKSMNLTVLAEGVEIEEQKDLLKSYGCDSIQGYYISRPVEPKEIEYMY--------
>tr|W7RW43|W7RW43_LYSSH Contig_9, whole genome shotgun sequence OS=Lysinibacillus sphaericus CBAM5 GN=P799_26740 PE=4 SV=1
------------------------------------------------------------------------------------HYLNSLPFPAIILNQD
GQATIWGKSAEHLIGLSTNDITGNTT----PSIHENLLRQLPVETFQAILQNDSTFEKIQIHTASKTEMSTALLAKPYTEGERLILMVFMPPELMTNAVS
HCSTFV---DLKQGLDATTVTLDHDGFILECNNEFLKTSQWTPKRVIGKTFWQLFPDNTSEKVTNTIWRNLNNGHTWQGEVEKITKAGQSYWVLLTAIPT
FNLETGEQQFFLIEKDITKSKTIQHQLEKIAYIDTETGLMNAHRLEKVISNMIE----DDRHFSFVYLSIDKFYTLKELHDQQIDQSLIIEFTNRIKMYF
-QDSTMARINENDFVVITPLSE-----WFIQGFLYLQQHPIYSGNIAVPISISGGITRYPEDQTTFSQLMKASIATISTVREAGGDKIVSLSTATHKALN
RKALIEKRLLQALDQKNLKVLYQPQIDVYSGKITAVEALVRWEDEVIGVVSPDELIPIAEETGLINNIGSFMLERACEQALIWKKAGHE-LKVSINSSVR
EFRDKNMAKSILEMIAKTGCPANLLQIEITEKFALEAETSIAQQMRKLENEGISFILDDFGTGYGSFRYMQILPIDTVKIDQTFTNSLLKSEKSQKLMNG
MVQLGKSMELKVVAEGVETAEQADLLITYGCDAIQGYYISKPVTPDEIEALL--------
>tr|A0A0A3HU07|A0A0A3HU07_9BACI Diguanylate cyclase OS=Lysinibacillus sinduriensis BLB-1 = JCM 15800 GN=CD33_07865 PE=4 SV=1
------------------------------------------------------------------------------------KMVNMSPFPTFVLNQS
NEVLIWNDLSKSYFGYGVEDFLNKT-----ADIKNGLLSSLSTDAYENILASEPLRENVRLLTKADTLIETTIFTSPITYNEPSILVTCILDESYARMDD
STKKLQ---DLINGLYSSVVTVDAEGLITNCNPNFLSISHWTPKRVLGKTFWQLFPDNNSKKVTDSIWKTINSGHIWEGEVEKITKDGLPYWVYLTAIPT
YSPTTQDYEFVLFEKDTTNERKMKHQLEKIAYIDPETGLMNSHRLEQVVNEMIE----ERRHFSFVYISIDKFYTIKELHSSKMEDNLITEFTKRLKIYF
-QDSEMARVNEHEFVVITPLGE-----WFTQGFLYLKQNPIYAGNVAVPISISGGITRSPQDQSTFPHLMKASIATIANVREAGGDNIVSLSNATHKAIN
RKSIIEKRLLLALDQQNLKVFYQPQVDIHTGKILAVEALVRWEDDQIGVVKPEELIPIAEETGLINNIGTFVIEEACKQAVKWHKEGLD-LKVTINLSVR
EFRDKNMAKSILTTLENTQCPAKLIQIEITEKFALEAETSIIKQMRQLEEEGIVFILDDFGTGYASFRYMQLLPIETLKIDQTFIQSLLQSEKAQRLIHG
MVQFGKSMNLTVLAEGVETKEQQQLLQEYGCDAIQGYLISKPVAEDVITKLM--------
>tr|X2GNZ9|X2GNZ9_9BACI Diguanylate cyclase OS=Lysinibacillus varians GN=T479_02050 PE=4 SV=1
------------------------------------------------------------------------------------HYINSLPFPAIVIKQN
GQATISGKHAEELFGFSVTDITGHTT----PSIHENLLRNLTSETFQAILHNESTYDKVQVYTHSEEEISSALLAKPFIEGEHLILIMFMLPELMINSVS
NSSTYV---DLKQGLDSTTVTLDRDGFILECNAEFLKISQWTPKRVIGKTFWQLFPENASEKITNTIWRNLNNGHTWQGEIEKVTKTGQSYWVLLTAIPT
FNLEANEQQFILIEKDITKSKTIQHQLEKIAYIDTETGLMNAHRLEKVITKMIE----EEKHFSFVYLSIDKFYTLKELHDQQINQSLIIEFTNRIKMYF
-QDSTMARINENDFVVITPLSE-----WFIQGFLYLQQHPIYSSNIAVPISISGGITRYPEDQTTFSQLMKASIATITNVREAGGDKIVSLSKATHKALN
RKALIEKRLLQALDQKNLKVLYQPQVDIYSGKITAVEALVRWEDEVIGVVSPDELIPIAEETGLINNIGSFMIEKACEQALIWKKAGHN-LKVAINSSVR
EFRDKNMAKSILDMLAKTNCPANLIQIEITEKFALEAETFITQQMRKLENEGIAFVLDDFGTGYGSFRYMQILPIETLKIDKTFTSSLLKSEKTQKLMHG
MVQLGKSMELKVVAEGVETAEQADLLITYGCDAIQGFYISKPVTPDEIEALL--------
>tr|A0A0A3J420|A0A0A3J420_9BACI Diguanylate cyclase OS=Lysinibacillus massiliensis 4400831 = CIP 108448 = CCUG 49529 GN=CD30_14430 PE=4 SV=1
------------------------------------------------------------------------------------NLILQAPFPSIILNNQ
NHVLIWNQLAEDFFHYSLSEFSD-N-----DHIKDSLFSSFTKDTWELISERDMLKENQYLLTSDDQLLEASIITIPSYYGELCTFVICLLNNQMKKINK
SSQELS---DLKEGLLSSVVTIDSEGFITNCNEKFLKTSHWTPKRVLGKTFWQLFPEAQSKKEAEEIWHTISSGEIWQGDVEKITKDGQSYWVHLTAIPS
YSGDHA--QYTLLEHDITDEKLMKQQLEKIAYIDPETGLMNIYRLEQIVNEMVE----EGRRFSFVYLSIDKFYTVKELHKNLNESSFISEFVKRLKIYF
-QDSSMARINSSEFVIITPLSE-----WFIQGFLYLKQNPIYNGNAAVPLSISGGITHSPTDQSGFYQLMQASLKAVQNVREAGGNNIASLSSKSHKALN
RKSLIEKRLLLALDQKNLEVLYQPQLDLNSGEIIAVEALVRWEDEEIGVVPPDELIPIAEETGLINDIGSFVIEEACKQAALWNERGVN-LKISINLSVR
EFRDKNMAKSILNTLSQTNCPASLIQIEITEKFALEAESYIIKQMRLLENEGITFVLDDFGTGYASFRYMQLLPIEILKIDQMFIHSLMMSEKTQRLIKG
MVQFAKSMNITVLAEGVETEEQLQLLKEFECDIIQGFLISKPVNAKEIKKLI--------
>tr|A0A0A3I3K2|A0A0A3I3K2_9BACI Diguanylate cyclase OS=Lysinibacillus manganicus DSM 26584 GN=CD29_06660 PE=4 SV=1
------------------------------------------------------------------------------------QIILNSPFPSFVMNKQ
HKLLLWNQLCEDVFQHSFNEFKD-T-----DNIKTTLLSTIPEQLLNLLSDHDKYQENIQLLTKDENLLESSIITIPSSYGELCTLVVCFLNDELRKVNT
STQELI---DLKKGLTSTFVAIDDEGFIINCNQKFLKTSHWTPKRVIGKTFWQLFPETEGEEAAEKIWKTITSGNVWHGEVEKITKDGQSYWVHLIAIPT
YSSTENRFLYNLIEHDITEEKLLKDSLEKIAYVDPETGLMNHYRLEQVVNENIE----NGLSFSFVYLSIDKFYTLKEIHNIQIENNFITEFVKRMKIYF
-QDSSMARINSNEFVILTPLSE-----WFIQGFLYLKQNPIYIGNVAVPISISGSITHSPKDQSNFTELMKASIKTIQTVREAGGNNISSLSATSHKALH
RKSMIEKRLLLALDQKHLEVLYQPQFDLSKGKIIGVEALVRWEDEEIGVVSPDELIPIAEETGLINNIGSFVIEKACKQAVEWFKKGLD-LKISINLSVH
EFRDKNMAKTILNTLSKTGCPAHLIQIEITEKFALEAEANIIKQMRLLENEGIVFILDDFGTGYASFRYMQLLPIEILKIDHTFIHSLMMSEKNQKLVNG
IVQFGKSMNITVLAEGVETEEQREVLKNYGCDLIQGYLISKPVNVKEIENIV--------
>tr|W4F3I3|W4F3I3_9BACL Sensory box, GGDEF family protein OS=Viridibacillus arenosi FSL R5-213 GN=C176_04238 PE=4 SV=1
------------------------------------------------------------------------------------SVLNQMPFPMMIVNHE
GIVAAWNRQAEKTFGYSADEVLGKFT----PFIEAE-KSGLHKEGWTKLLRSEPFHDKMAFIAKNKEAIFSSALAKAFTINERYVFFHFEMTDEIQKDPS
PYQELI---SLKSGLESSMLTMDQEGLINFANNNFLKRSKWTPKRIIGKTFWQMFPQTDGTADANNIWTSLKNGKAWKGEVEKMSKDGLSYWVDLTAIPI
FVTCKNPSYFILLENDITEKKLLQNRLEKIAYIDQETGLMNRYRLEQIVTDMIQ----EKNHFTFVYLSIDKFYSLKEIYDEQTEIVLLQEFTNRMKIYF
-QDSTMARVGIDEFVVLTPLGE-----WFIQGFLYLKQHPIYVNNRALPLSISGGITKYPEDQSSFSHLVKASHAAISKVRSDGGGNIISLTKADHKALS
TKAIIEKRLLIALDKKNLKVLYQPQLNLETGNITGVEALVRWEDEEIGIVTPDVLIPIAEETGLINDIGAFMLEQACLQAVAWHKKGLD-LKVSINSSVR
EFRDKNMVQHIRKVLEKTNCPAKLLQIEITEKFALEAETSIIQQMKQLEADGIVFVLDDFGTGYASFRFMQLLPLAEIKIDQTFISTLQYQKKAQKLIQG
MIQFGKSINMRVLAEGVETAEQLELLTSFGCDAAQGYHISHPITPKEVENLL--------
>tr|S2XMX4|S2XMX4_9BACL PAS domain S-box protein OS=Paenisporosarcina sp. HGH0030 GN=HMPREF1210_01868 PE=4 SV=1
------------------------------------------------------------------------------------SILDHVPFPMILTASD
ATVLWWSREAERTFGFTADEIVGKFY----PFFEEN-RSAIHKSTWGQVVQSIPIRENFIIHSKHGKAVHVSAVLNSMTINEQCVMFLFEVNNVPTMQTS
STQELA---SFKMGIDETLTYLDPDGLITYANTLFLKTSKWTPKRIIGKSFWQLFPEEA-EKSVNPIWYTLNSNRVWQGSVEKLTKDGETYWVDMTAIPV
LATNDEPMYFAILEKDITDKKRLQLHLEQIAYVDSETGLMNRHRLENIVSGLIA----EERHFSFIFLDIDKFYTLRDMHDEESETTLLLEFAKRLKMYF
-QDSDIARVGEDEFVVLTPLSD-----WFIQGFLYLKQHPIYIRNKAIPISISGGITRYPEDQSTFLHMMRASSATIHKVKQEGGGNIVSLSKANHVALS
RKAMIEKRLIEALHHKDLTVMYQPQVDLKTGKIDAVEALVRWEDAVLGTVTPNDLIPVAEETGMIHDIGSFMLEKACEQAALWAKNGKP-MKVSVNSSIR
EFRDKNMVKQVRQTLEKFGCPAHLLQIEITEKFALEAEQSIIRQMHQLQSEGIRFVLDDFGTGYASFRYMQMLPITELKIDQSFIASITKQEKLQKLVHG
MIQFGKSMEIRVLAEGVETKEQQDLLTKLGCDAIQGFYISHPVSAGEIENL---------
>tr|A0A078M7L9|A0A078M7L9_9BACI Oxygen sensor protein DosP OS=Lysinibacillus sp. 13S34_air GN=dosP PE=4 SV=1
------------------------------------------------------------------------------------FYAELLPFPTFIISED
GTIISWSSTAEAVLGYKKNTMLAQPA----STVTTLLSGDFSPSAFADLIAKKTEQTAISVQLADHTLQMAELVTQPCTYQQKSLLCALIFDNTSVDGAI
LLKELV---DIRLALEETLVTLDSEGFILAANEAFLKASLWTPKRIIGKSFWQLFPEKASQSIPEQIWRTLQQGRIWQGEVEQLTKTGTTYWTDLTAIPT
YCPIRKVQHTILVCKDISSTKNELMKLQKFAYVDAETGLHNSYWLENELPKLVM----EQREFSFVYLSIDKFYTIKELHSSELHESLGSMFKQRLETYF
-QDSIIVRINEIDFALLTSLSD-----WFIEGFLYLEKNPIYYERLALPISISGGITRFPSAFTTYTQLMRTSTATVAKVRSEGGNKIVSLTPAHHRQLN
RKSLLETRLLKALDEKNLQVLYQPQIDITSKKVVGVEALVRWHDEVVGTVSPGELIPLAEETGLIHQIGLFVLREACLQAVKWSAAGTP-INVSVNSSVR
EFRDKNMATSVLSILKETNCPASLLHFEVTEKFALEAEKSIQMQLEQLEQAGVSFVLDDFGTGYASFRYMQILPVNSFKVDETFIHTINKSEKANRLVHS
MVQLGKNLGLRVVAEGVETHEQQAYLQSIDCDILQGYVISKPITAQAVSELL--------
>tr|W3AHI5|W3AHI5_9BACL Diguanylate cyclase OS=Planomicrobium glaciei CHR43 GN=G159_03660 PE=4 SV=1
------------------------------------------------------------------------------------LVFNHIPFPIIIMDKD
GLVVWCNRHAERVFQVESSSIKGQLY----PYMNPE-KAALYKHSWETILHSEPVREDVEVGLGTGGHTYTTIVTKAFAAGEQFIMSIFEVDEADE-EGS
ASRELN---SLRNGLDDSLLYFDEDFLITYANPLFLKLSKWTPKRILGKPIWQMFGEAEDVHFVETLTATLKNGKVWNGQAKKLKKDGDVYWVDLTAIPM
QV-KGDDTYYIFLEKDITASKNAQHHLEAIAFIDPITGLENRHRLEQVVNEFIE----ERKHFSFVYMDIDRFYTLQDVSDTDTENELLVEFTKRLRMYF
-SDSIITRAGLHEFALVTPLSN-----WFIEGFLYLQQHPIYMHGTAIPLTVSGAITRYPEDQQSFVHLIKASHATIKKVKERGGSAISALTSDDHERLN
RTSLIERRLIHALDRRNLRLLYQPQVNLSTGKVEGVEALVRWEDSEIGIVTPDELIPIAEESGMIHEIGRFVLETVCAQQKEWKSRGID-LNVSINSSIR
EFRDKDMAKVFLEQLALNEGVANSLTIEITEKFALEAEQSIIKQMKQLHQAGISFSLDDFGTGYASFRYMLLLPISSLKIDRDIIQSITKQEKMQKMIKG
MIQFGKSLDFQVTAEGVETNEQLELLRAMDCDIIQGYISGRPMEAHDLEKWL--------
>tr|I4X6X4|I4X6X4_9BACL Sensory box, GGDEF family protein OS=Planococcus antarcticus DSM 14505 GN=A1A1_05772 PE=4 SV=1
------------------------------------------------------------------------------------LVFNHIPFPIIIIDQN
GLIAWCNQHAERVFQIESEAVKGQFS----PYMNPE-KAALSKHSWDKLLHTEPVKEDVEIELGDGIKAYTSVVTKSYTSNEQFVMTIYELDEADE-EGS
APKELN---HLRNGLDDSLLYFDEEFLITYANPLFLKLSKWTPKRILGKPVWHMFGDGSDVQFVDSILTTLRQGNVWNGEAKKTKKDGEIYWVDLTAIPM
QL-SSDDTYYIFLEKDITANKKAQQHLEEIAFIDPVTGLENRHRLEQVVNEYIE----EGRHFSFIFLDIDRFYTLRDLSDTDTENELLTEFTKRLRMYF
-SDSIITRAGLHEFALITPLSN-----WFIEGFLYLKQHPIYLQGTAVPMTVSGAITKYPEDQQSFMHLIKASYATIKKVKDRGGSAISALTSDDHERLN
RKALIEKRLIYALDRRNLQLLYQPQVNLNNGKVERVEALVRWTDSEIGVVTPDELIPIAEENGLINEIGSFVIETVCRQLSDWQSKDID-LQISINSSIR
EFRDKDMTKMLLEQLKINNCKASSLMIEITEKFALEAERSIMTQMKMLHQEGISFALDDFGTGYASFRYMLMLPISSLKIDQMIIQSITKQEKIQRLING
MIQFGKSLDFQVTAEGVETNEQFELLRAMGCDSLQGYIIGHPMSATDLEKWL--------
>tr|E7RGI0|E7RGI0_9BACL Sensory box, GGDEF family protein OS=Planococcus donghaensis MPA1U2 GN=GPDM_07890 PE=4 SV=1
------------------------------------------------------------------------------------LVFNHIPFPIIILDKN
GLVTWCNQHAEHVFQIKAEAVIGQLS----SYMNPE-KAALNKHSWDKLLHTESVRENIEIELAGGVTTYTTVVAKSYTFGEQYVMTIYEMNEADK-DGS
SSIELN---HLRSGLDDSLLYFDQEFLITYANPLFLKLSKWTPKRILGKPVWHMFGDGEDVQFVDSILSTLRQGEVWNGEAKKVKKDGEIYWVELTAIPM
QL-SSEDTYYIFLEKDITANKQAQKHLEEIAFIDPVTGLENRHRLEQIVNEYIE----EGRHFSFVFMDIDRFYTLRDVSDTDVENELLIEFTKRLRMYF
-SDSIITRAGLHEFALVTPLSN-----WFIEGFLYLQQHPIYLQGTAVPLTVSGAITKYPEDQHSFMHLIKASYATIKKVKERGGSEISALTPDDHERLS
RKASIEKHLIYALDRKNLQLLYQPIVNLANGKVERVEAFVRWTDSEIGVVTPDELIPIAEENGLINKIGSFVVETACLQLKDWKSKDID-LQISINSSIH
EFRDKDMAKMLLENLKLNDCHPSSLMIEITEKFALEAERSIMTQMKNLHQEGITFALDDFGTGYASFRYMLLLPISSIKIDQMIIQSITKQEKIQKLING
MIQFGKSLDFQVTAEGVETNEQFELLRAMGCDSLQGYIIGHPMTATDLEKWL--------
>tr|A0A098EHU2|A0A098EHU2_9BACL Oxygen sensor protein DosP OS=Planomicrobium sp. ES2 GN=dosP_1 PE=4 SV=1
------------------------------------------------------------------------------------LVFNHIPFPIIIMDKD
GLVVWCNRHAERVFQLEPETIKGTLY----PYMNPE-KAALYKQTWDNIIHSEPIREEVEVGLGDGTRTYTTIVTKAFASNERFVMSVFEVDESTE-EIS
ASRELN---SLRDGLDASLLYFDEEFLITYANPLFLKLSKWTPKRILGKPIWQMFGEEEDVSFVENLVSTLRSGKVWNGQAKKLKKDGEEYWVELTAIPM
DL-KGDDTYYIFLEKDITEAKKAQHHLEEIAFIDPITGLENRHRLEQVVNDHIK----EGKHFSFVFFDIDRFYTLRDVSDTDTENELLSEFTKRLRMYF
-SDSIITRAGLHEFALITPLSN-----WFIEGFLYLQQHPIYIQGTAIPLTVSGAITRYPEDQQSFVHLIKASHVTIKKVKERGGSAISALTSDDHERLN
RKSMIEKRLIHALDRHNLHLMYQPQVNLSTGIVERVEALVRWEDSEVGIVTPEELIPIAEENGMIHEIGMFVLETVCAQIKDWNSRGIH-MNVSINSSIR
EFRDKDMAKSLLEQIQLNSCDPSALTIEITEKFALEAERSIIKQMKQLNQAGISFALDDFGTGYASFRYMLMLPISSLKIDRAIIQSITKQEKMQKMIKG
MIQFGKSLDFQVVAEGVETNEQLELLRAMNCDMIQGFITGHPMEAKELEKWL--------
>tr|E6TYR4|E6TYR4_BACCJ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Bacillus cellulosilyticus (strain ATCC 21833 / DSM 2522 / FERM 
----------------------------------------------------------------------------------------------------
----------------------------------------MEI-----------NKPSIEKKTIEKNYH----SHLPKWFHVPSIESDQALD------QQ
YEQLIS---RFKIALETTIVLVNDTGAITYVSEEFCDLLDYSESELIGVNYLSLQHRSFKE---RELFSNTLASKITSFEMIPLKKSGNPLILKTQIMPL
IKSNQESDIFLIMHRDVTRLKQAEKVIKELGAVDTLTGLPNRDKFERDVRSRIEMKHAEKFPFAILFFDLDRFKFYNDTLGHFTGDKLIQSISQTLSSIQ
HKKVQIYRYGGDEFSVLFHSPKSKEVQELAQEILLAFESPFHVKGNELYITASIGISYFPVIGVTYDQIIQQAEMAMHYAKELGKGDFQWYQSSIRTEHD
EKLLMEKRLRIAMEQENFELYYHPQIDLKENKVIGVEALLRWNDEQLGKVSPYKFIPIAEETGLINQIGDWVLEKACIQAKKWNNEGHE-LRIGINISPQ
QFQRPDFVSKVKNTLDKTGLSPKLLDLEITENDLLYNRDECLKTLYRLKQFGVSISIDDFGTGYSSLSYLRRFPIDTLKIDQSFIKEVVDNTNDQAIVTS
IIQLAHNMKLRVIAEGVETSEMVAFLNKLSCDEMQGFLYSQPLPPEAVTKYI--------
>tr|F3BK05|F3BK05_PSEHA Sensory box/GGDEF/EAL domain protein OS=Pseudoalteromonas haloplanktis ANT/505 GN=PH505_ay00320 PE=4 SV=1
------------------------------------------------------------------------------------------------YDNE
RRVIYWNEGSERLYGYTKEEAIGQKI---EDLIIPEPMCEFVIDAHSDWV--KDIEPASEITLKGKDGESVSVFSSHVMFNQYCIDIDLSEVKKAQAASF
NEDMLK---TIFEAIPDLFLMKNDGTIIEYHASNETDLY-TKPKQFIGKKMGDVLPRDVAEKF-ETYISLVLEKQMMSFKYELALPHGLV-FFEARI---
-NKITEHNQLMVIIRDITEQHKSDEIIRHQAYYDSLTLLPNRFLALDRLSQLLIEAQRNNEKAAVLFLDLDDFKKINDSLGHETGDKLLIESAQRLQEAL
RKDDTVGRLGGDEFIVLLRGITDHHALKITEKLLNNFRAPFKIEGREHILTASIGVAIYPENGTTVADLLRNADTAMYQAKSYGRNTYSFFTKKMNVIIQ
RRLVIEEQMRDALERNEFELFYQPQFDAKNKHIIGAEALLRWHNPVLGNVTPDEFIPIAENTGLIVPIGKFVISQALHFLNTWQSTCKR-QTMAVNLSPR
QFRDVGLLSFIQNSLSEANVNPESLELEITEGVLMSCHTNVVDILTEITALGINLSMDDFGTGYSSLSYLREYPFNVLKIDRSFIDGIVLNNEDCNLVKA
IIAMSHSLGLTVVAEGVETKEQHTLLNELGCDFMQGFYFSKPIPAKQFLDFS--------
>tr|A0A0A5G618|A0A0A5G618_9BACI Diguanylate cyclase OS=Pontibacillus litoralis JSM 072002 GN=N784_04405 PE=4 SV=1
------------------------------------------------------------------------------------RMMDH-ASQFLFIHND
QQILYVNPATIDMLGASDARITGHSL---SDFSLT-----YDVESRDDIS---DVCMNQQVKRLNGEYETIRMMSIPIIFQQMCIGIKDADS------SK
THQQFI---NINDALNESIAITNRQGVITYANQMFCDISQYKQEELIGQTHRIIHSNHHSKEFFKDIWRTICEGNVWKGEIKNRAKDGSHYWVDTTIVPI
LDHNQKPYQYVAIRHNITKSKEMEESRERLANYDPLTQLPNRYNVSQYLARALRDV-RIGKQLAVMFVDFDGFKLYNDTYGHSFGDELLKSVAERLQETV
AKYGKIGRYAGDEFLIIVNNT-DRKVERIAKRINKEFETPFIVMGRELFITLSIGISLYPFDGLDSETLIKNADTAMYRIKRLEKNGCSFFEEKYKHSNL
TKINIENGIRKALRNDEFRLLYQPKIDLKTNTIVGTEALVRWESPEWGTVSPGKFISIAEETGLIVPLSKWVLHTACHQAKQWHNQGLT-LV-AVNISVR
QFYLENVVATVSDVLRETGLNPKHLTLEITESIFQDV-VKSKRILQQLKEMGITISIDDFGTGYSSLSILNQLPIDQLKVDKSFIDDVPENENAVTLVKT
IMNMGKHLGFEMVAEGIEDIEQETFLKKHECDIVQGYYYSKPVSPMEIQTYY--------
>tr|Q21WZ6|Q21WZ6_RHOFT Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) GN=Rfer_1982 PE=4 SV=1
--------------------------------------------------------------------QRRAETALHESEQRHRLLADNASDVIWTMDLK
GRFTYVSPSVEKLRGFTSAEVMQQT---LAQTLCPSSIPVLGKSM-ASMAAGLPFRGELEQPCKDGSTVWTEISTNGMRNEQGDFVGIVGVSRNITERKA
QQQQLQLAAQVFAQGREGITVTDARGHIIMVNRAFSEITGYTQAEVLGQNPRILKSERQSPEFYLDMWTALTTSGHWAGEMWNRKKDGTVYPEWMAISAL
RDSQGLTTHYVASFSDLSTAKAAESRIQWLSQFDTLTGLPNRTLLQDRTALALSMVQRAREPLTMLLVAIDHFGAVNDTLGHQLGDELLVEMARRLSDSV
REQDTVSRMGGKEFVLVLPGTPAMGAAHLATELLWKLSRPCSLGMHELTLTASIGIASFPDNGADFDTLFKAVEIAMHRAQLKGRDTYQFYSDDMYEQVL
AHDRLIKALRQAIVLDQLQLVYQPQVDLQTGQICGVEALLRWQHPELGAVSPGQFIPLAEESGLIIGIGEWVLRRACQDIRRWLDHGIKVPHVAINASPL
QFRDNNLVLQVKAALTESQIDPALIYIEVTESALMDDVPRNEAMLKALKDLGIKLSLDDFGTGYSSLSYLKRFPFDQVKIDQSFVRDIATSQSDSLLVKV
IVSMAHGLGMKVIAEGVETEAQCEIMRTSICDEIQGYFFCKPISAQAIEELFSE------
>tr|A0LA87|A0LA87_MAGSM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Magnetococcus sp. (strain MC-1) GN=Mmc1_2380 PE=4 SV=1
---------------------------------------------------------------------KQAELKLLESRHHLDRAQRLAGLGYWSWNLQ
GDEQFWSEEIYRMLHRPRAHVSASF-ESYMDHVHPDDRQRVRDMVARVLEPDLFFRVEHRIVRSDGNVRTVLQLGDVERSASGEPVRMTGTVQDITDLKR
TQENLDLAKYILDTTSDAVIITDVNNRIIDVNHAYTKITGFSRDEVMGQNPQVVHNEEQGEAFYSRIWQSLLQEGRWSGEVWERRKNGELYPKWMTMRRM
LNQYGETAFFVGVFVDISTQKATEEQMERLAYYDPLTKLPNRALFHERLTQSITTAKRYKRHVGVVMLDLNRFKLINESYGYGVGDGLLIQVAERIVERL
RESDIVARIGADTFAITLVDLKQGEITGVANNLLKQFVMPFLVNGHELMLRTAMGIVLYPTDGQDAETLLRHVENALGQAKQQGVNNYRFYSEEMSNISN
KRLALEQEMHTALEQRDFVLYYQPKVNLQRGVVSGVESLIRWQHKQKGMISPVEFIPVAEETGLIVPMGLWILETACAEAKRITDYLGQPFTVAVNLSAR
QFQSRNLLESISETLNNSAIDPSMLEFEITESMMMGNVEKSIETLVAIRNMGVTLAIDDFGTGYSSLSYLKRFPINTLKIDQSFIRDLGVDSDDAAIVSA
IISMAQDLNLHVVAEGAEKAEQVLFLKERGCETVQGYYFSRPLPQTDLERLLKD------
>tr|A7NJD0|A7NJD0_ROSCS Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Roseiflexus castenholzii 
-------------------------------------------------------------------------------------VLRSNDAVL-LIGRD
GRVNQANAAAAALFGVLTERLIGEP---FGTPIVSNLAT----TIDIPRRNDEPIAAELFLLHV--------------L-DDRSDDAYLAILRGISRHHR
LDVDLRLMMAAISSTSDGIVIADLDGVPHYQNPAFQKMTGLTLDDLRMAGGRYRDVGT-----ARAALSAVRSGQSYRGEMRLIDRQGAAISVLLHIDPV
LDASNQVIALVAVHTDVTQRKLTEDRLAYLSSHDPLTGLANRTLLLDRLQLALERRNRHGALCGILLLDLDRFKQINDSLGHMVGDEVLIAVAGRLKHIT
RPGDTVARLGGDEFAVVLDSVGSDDIWRIALRIQQALSHPITVQDQSLMVGVSLGIAIDDGRTTSAAALLRDADTALHQAKARGRSRIVLFEEAMHTAAT
TQLQLEIELRQALHRQALLLHYQPIVDLASGAIRGFEALMRWHRPLSGLVLPDGFLPVAEEAGMIPAMGAWSIVEVCRQARRWRDQFGSELPVSVNIHSR
QLEQTELPHQVRQALREFNLPGAALTIEITEKATLRDLDLVVTQLQQLKELGVQVVLDDFGTGYSSLGHLARLPINGVKIDRSFVQSMMHDPLSITIVRA
VITLARELNLGVVAEGVETEEQRAALLQLGCTCAQGWLFGRAVDAEAAAEWI--------
>tr|A5UZP0|A5UZP0_ROSS1 Response regulator receiver modulated diguanylate cyclase/phosphodiesterase OS=Roseiflexus sp. (strain RS-1) GN=RoseRS_3739 PE=
-------------------------------------------------------------------------------------VLRSSNPAL-LINRD
GRITQANPAAVTLFGDLTGQLIGEP---FGTPIVSNLVT----TIEIPQRNGAPITAELFLLHV--------------L-DEHSDDAYLAILRAASRQHR
LDVDLRLMMAAISSTSDGIVIADLDGIPHYQNPAFQAMVGLTLDDLRAAGGRYRDPGV-----ARAALAAVRNGQSYRGEMRLIDHRGNALNVHVNLDPV
LDPSGRAIALIAVHTDVTQRKLTEARLAYLSSHDPLTGLANRTLLLDRLQQALDRRNRERSPCGVLLINLDRFKQINDSLGHAVGDEVLIAVAGRLKHIT
RPGDTVARFGGDEFAVVIDSPGSEDIWRVAKRVQHTLNHPVTVQDHSLTVGVSIGIAVDDGRAKDAMTLLHNADTALHQAKARGRSRIVMFEEAMHTEAA
RQLQLEIELRQAVQHQTLEMHYQPIVDLCSGELYGFEALMRWQHPSHGLLFPDSFLPIAEEAGIIPTLGNWSIAEVCRQARRWRDRFGADVPISVNIHSQ
HLDQADLFAQVEQVLRQQNLPGAALTIEITEKAALNDLDLVLSQLLPLKALGVRVMLDDFGTGYSSLSHLARLPVDGGKIDRSFVQSMMHDPHAATIVRA
VITLARELQLNVVAEGVETEEQRAALLQLRCPYAQGWLFGRAADADTMTRVL--------
>tr|H6SQ04|H6SQ04_RHOPH Rhodospirillum photometricum DSM 122 draft genome sequence OS=Rhodospirillum photometricum DSM 122 GN=RSPPHO_00648 PE=4 SV=1
-------------------------------------------------------------------------------------VIDMAPDLV-CILQG
GVIRHVNPAGAALLGVSPAALIGRR---IEVLIHGRLRD----VLDRPRGGRRPVPAVLLQGDP--------------L-GGKSLGTLVFLARDVSRAHR
ADRQAAFLRAVTDTMVDALIVADEGGRIERFNKAAERLFGVTAEDMIGRDRRFMKSGC-----ARVI--------GLGRELRARRLDGSEFPIELALSVV
E--QEGRRRFVAVVRDITERKEHEAQLVTLATRDPLTGLPNRVLLREHMEQALG-----TGPFAVLFVDIDHFKKINDTLGHVVGDQVIRAMAQRLESHC
QEGDMVAHLGGDEFTVIVGQVHDEAVCARAEALMADLIRPYDVAGREVFTTVSVGAVCSPQDGIDVATLLRNVDTAVHHAKRQRRSSVVLYTPKLSADAV
RRLHIETGLRRALERNEFDVHYQPKVDLMNGDILGAEALLRWDGRDVGKVSPMEFVPVAEETGLVQPIGEWVLRRACTQAALWRDRGLGPVRMGVNLSAR
QFNDPDLVTKVRTILEETGLDPSMLDLELTESMLVEDGDQVVAVLRRLKALGITLSIDDFGTGYSSFGYLKRFPIDFIKIDRSFVVDLPNNIDDMAITRA
IASMASALRLRLVAEGVETNEQVAFLRTLGCDQGQGFLYSRPVPAVAFEALL--------
>tr|U7P9I2|U7P9I2_9GAMM Uncharacterized protein OS=Halomonas sp. PBN3 GN=Q671_17185 PE=4 SV=1
----------------------TLEDRLLQLVVTDEVELLV-VTLVD---------------VTE---ITQTQTALRESRAQLDALMRSTTILLAMKDLS
GHYQYANPSFCEAFGFDEDEVIGKT---DFQL-FPEPFAAWSRDMQS-LRETQPVAMEH--LLPGESERVLATMHQVLRDADGHPTAIVTEAEDITLRKQ
AERQLRVSAKVFEQAGEAIVVTDREARIQSVNDAFTRITGYRADEAIGHKMDLLRSGKNDPSLYQAMWRSLSARGFWQGEIWNKRKNGELFPEWLTINRI
DEDD--NQHFVAVFADISKLKASQRQAEYLATHDALTGLPNRTLFHDRLDLAMAQARRSASQVALMFLDLDNFKDINDTLGHDVGDKLLTQVAGRLNEIV
RDMDTVARLGGDEFTVILNDTSVAGAERVAQRIIETLHDPVVVDQRSLYVSASIGLAFFPDDGDDAASLTKAADTAMYRAKDSGRDRFELFKPELQAQLV
EQVNMENALRQALKAKHFRLAYQPKFVIMDGRLFGAEALLRWHDPTQGEVPPGDFIPAAERSGLIVEIDRFVAHLAVESLARWRSQGFPSLPVSINVSAR
SFQDDRYLDALLEGLRTYRIPPDLIQLELTERTLVDRTSMALGNIERLREAGIQLSVDDFGTGYSSLAYLKRLPLAELKIDKSFVDGLDGDRNDEAIVRA
ILGMAEALELRTVAEGGETEAQHSWLAEHGCDVLQGYLMARPEEEEIY------------
>tr|M5QV35|M5QV35_9BACI PAS, GGDEF and EAL domain-containing protein OS=Anoxybacillus sp. DT3-1 GN=F510_0857 PE=4 SV=1
---------------------------------------------------------------------------------------------IAVIAPN
GKILGADEHFFQHFYHREVDR---------ELLEK---------FIQEAENGRT--VSYAIVKQKNGQNDVYVQATALYNKEGNLQAVVATYQYEPFIDM
-----RLTSSIASLASEFTFILSAEGEITYVSPTAQYVLKVCSHELFSFVHED---IPLLMEKLHTIYATKEKE--TTVDCRWRTNEGRFIWIHMHAHPL
LNEQNEIEHVIVVAKDITKWKCCEEALAKLKHFDSLTDIPNRFYFESYVQHMIQQ----KRPFALCYIDFDKIKWINDRFSYQAGDFFLQEAVRRIQQHL
QKEDFFSRIGGDEFVIVLHDVNKETIVTRMEHLLQSFVEPFRYKEHVIQSSLSVGVTFFPQDGMDLDTLLKQADQALCYAKERGK-GYHFYHPQQN----
RKTMIEQELPLALLNNQFYLCYQPKVSLDNEAIMGVEALMRWTHPTLGAISPLEFIPIAEKNGFIFEITTWVLKEACQQVKQWQTH-FPTLKLAVNLSPF
LLNRKEFVTHVKNILQHTQFPPNYLILEITESGLMENIETGKHILTQLKQIGIQVAIDDFGTGFSSLAYIRNLPVSLLKIDRSFIRDITDNSKDATIVDT
IIHLAKSLDLQVLAEGVERDDQVSLLQKMDCDFAQGFYFSQSLEAEKLLQWLEQH-----
>tr|B7GKP9|B7GKP9_ANOFW Multidomain signal transduction protein (Contains PAS, GGDEF and EAL domains) OS=Anoxybacillus flavithermus (strain DSM 21510 /
---------------------------------------------------------------------------------------------IAVIDQN
GKILGADEHFFRHFHHLRVNR---------ELLKK---------LIHDAEHGRI--VSYDMLKED-ERKNIYVQATALCNKTGMLQAIVVMYRDAPFIDM
-----RLTSSMASMASEFTFILSSEGEITYVSPSAQHVLKVCNHELFSFVHDD---IPLLMEKLHTIYATKEKE--TTVECRWRTHKGHFIWMDMHAQPL
LNEKNEIEHVIVVAKDITKWKCCEEELIKLKHFDSLTNIPNRFYFETYAQHRIEK----MRPFALCYIDFDKIKWINDRFTYQAGDFFLQEAVRRIQQHL
QQEDFFARIGGDEFVIVLHDVNKETMVARMEHFLQSFVEPFRYKEHVIQSGLSIGVTFFPQDGTDLDTLLKQADQALFYAKERGK-GYHFYHPQQN----
RKRMIEQELPLALLNNQFYLCYQPKVSLDNKSIMGVEALMRWTHPTLGAISPLEFISIAEKNGFIFEITTWVLKEACRQVKQWRTH-FPTLKLAVNLSPF
LLNRKEFVTHVKNILQETQFPPNYLILEITESGLMENIETGKHILTELQQIGIQVAIDDFGTGFSSLAYIRNLPVSLLKIDRSFIRDITDNSKDATIVDT
IIHLAKSLDLQVLAEGVERDDQVSLLQKMDCDFAQGFYFSQSLEAEKLLQWLEQH-----
>tr|C5D2S1|C5D2S1_GEOSW Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Geobacillus sp. (strain WCH70) GN=GWCH70_1982 PE=4 SV=1
---------------------------------------------------------------------------------------------VAILNTE
GYVIYTNPAFQALLGTNGSGA---------VRHEP---------LLQSVRNGKSINVEWTIKKADDRIVPVSAVFSPIVNEQGEIDSILCVCRDVTKLER
ALESKQHFQLIAEHSTDYILIFSNKRELLYIPSSLEKVGTYSYEDILQFVPDD---LPNIVRKFDELYRTYDTQ---IAEFRKRDNEGKWIWMEAQGKAI
VNEQNELDYVIVTVKNIGERKKYEEKLRQLAYFDSLTGIANRSYFERYIKQLIES----QTDFALCYLDFDKFKWINDHFSHQAGDYFLQEAVRRVQSVL
RTEDFFARIGGDEFVLLLPNITKEEVTKLADELVQTFHKPFYYEKQLIQSTLSMGIAFFPKDSDRIEQVMKYADQALYNVKKRGKNGYEFYRPTQN----
RKAIIEQDLPFAILREQFYLCYQPKIKLDSGATMGVETLLRWRHPSLGEIPPLDFIPLAEQSGFIFEITLWVLEHSCRQVKEWQTQ-FPGLKLAVNLSPF
LLNRTELVQHIVHILRDTHFAPEHLILEVTESGLMENFETGKHILTQLKNIGVQVAIDDFGTGFSSLAYIRNLPVSLLKIDRSFIQGIAENSKDATIVDT
IIHLAKSLDIQVLAEGVETYHQVALLQQMDCDFAQGFYFSKSLEAEKLQKWLEEY-----
>tr|S5ZN16|S5ZN16_9BACI Diguanylate phosphodiesterase OS=Geobacillus sp. JF8 GN=M493_07490 PE=4 SV=1
---------------------------------------------------------------------------------------------VVIFNWQ
GVMIYQNPAFDRLALGREEKE---------ALA-----------QA--KRMKERLTFQIELP--G---GSFVAGMSPIIDERGQAAAMLCVLRRQTGLQA
RLAAERRLQLIVEHSSDYVLIFSRHGELVYIPPSWKRKTNISREDVLAFVPDD---APVVAQKLAELYSTYEVQ---TVEFRKRGEQGEWIWVEAQGKAI
LDEAGALDCVIVTVKNISERKRYEEKLRQLAYFDSLTGIANRSYFERHIDGLITG----RTPFALCYLDFDKFKWINDHFSHQAGDYFLREAVKRVQQAL
RPDDFFARVGGDEFVLLLPNVTKTEMTTLAERLVSSFHEPFYYEKQLIQSTLSVGIAFFPQDSDRIEQVMKYADQALYEVKERGRNGYAFYRPTEH----
RQAIIEQDLPFAIMRGQLYLCYQPKVRLAKGRTMGVEALLRWRHPVLGDIPPFDFIPLAEESGFIFEITLWVLERACRQVKEWERK-FPGLKLAVNLSPF
LLNRPELVEHVKRILRETGLAPDRLILEVTESGLMENIETGRHILIELQQLGVQAAIDDFGTGFSSLAYIRNLPVSLLKIDRSFIQGIVENSKDATIVDT
IIHLAKSLDIEVLAEGVETESQVVLLSQMACDYAQGFYFSRSLEAEKLQQWLEEH-----
>tr|A0A023DHA8|A0A023DHA8_9BACI Putative signaling protein OS=Geobacillus caldoxylosilyticus NBRC 107762 GN=GCA01S_047_00360 PE=4 SV=1
---------------------------------------------------------------------------------------------VAIFSTE
GDMLYRNPVFQALFSANEYDD---------QA-IP---------LLQAVKNGESIHIEWTIRTSADDIILVRASFSPIVNEQGEVDAFLCVCRDVTKLKQ
MLETQQRLQLVVEHSTDYILIFSNQRELIYIPSLWKKEEMCSYEDIFQFIPDD---LPIIRQKFDELYHTYKAQ---IAEFRKRDRRGNWIWMEAHGKAI
VNEQNELDYVIVTIKNIGERKRYEEKLRQLAYFDSLTGIANRSHFERYIKQLVES----QTAFALCYLDFDKFKWINDHFSHQAGDYFLQEAVKRVQSVL
RAEDFFARIGGDEFVLLLPNVTKEEMAKLADKLVTAFHQPFYYEKQLIQSTLSMGIAFFPKDSDRIEQVMKYADQALYNVKEQGRNGYAFYRPTEN----
RKAVIEQDLPFAIMCEQFYLCYQPKIKLGSGAAMGVETLLRWRHPSLGEIPPLEFIPLAEASGFIFEITLWVLEHACRQVKEWQMK-CPGLKLAVNLSPF
LLNRPELIHHVKHILHATNFAPEHLILEVTESGLMENIETGKNILTELEKIGIQVAIDDFGTGFSSLAYIRNLPVSLLKIDRSFIQGIAENSKDATIVDT
IIHLAKSLDIQVLAEGVETYPQVALLEQMHCDFAQGFYFSKSLEAEKLQQWLEEY-----
>tr|A0A093TTJ4|A0A093TTJ4_9BACI Diguanylate phosphodiesterase OS=Geobacillus sp. G1w1 GN=EP10_16555 PE=4 SV=1
---------------------------------------------------------------------------------------------VAILNGQ
GTMIYRNPTFAGLALSEETEK---------ALM-----------LA--KRMKEQLAFQVELS--G---GAFVAGLSPIIDERGQAAAILCVLRRQAELRA
RLAAERRLQLIVEHSNDYVFIFSRDRQLSYIPPSWQGKMNASYDDMLAFVPDD---APVITQKLANLYDTYETQ---TAEFRKRDEHGEWIWMEASGKAI
IDEAGKLDCVIVTVKNISERKQYEEKLRQLAYFDSLTGIANRIYFERQIGELMAS----GTPFALCYLDFDKFKWINDHFSHQAGDYFLREAVKRVSREL
RHDDFFARIGGDEFVLLLPNVTKTEMTALAERLVSSFHEPFYYEKQLIQSTLSIGIAFFPKDSDRIEQVMKYADQALYEVKERGRNGYAFYRPVEH----
RRIVIEQDLPFAIMRGQFYLCYQPKVRLTQGRAMGIEALLRWRHPTLGEIPPLDFIPLAEESGFIFEITLWVLERACRQVKEWERK-FPGLKLAVNLSPF
LLNRPELVEHVKRILRETELAPDRLILEVTESGLMENIETGRHILTELQELGVQAAIDDFGTGFSSLAYIRNLPVSLLKIDRSFIQGIAENSKDATIVDT
IIHLAKSLDIEVLAEGVETESQVMLLSQMHCDYAQGFYFSRSLEAEKLQQWLEKY-----
>tr|L7ZRA5|L7ZRA5_9BACI Diguanylate cyclase/phosphodiesterase OS=Geobacillus sp. GHH01 GN=GHH_c14560 PE=4 SV=1
---------------------------------------------------------------------------------------------VVILNLQ
GVIIYNNPAFAGLALSEEEQR---------TLS-----------LV--ERVKQRPAFRWELL--D---GLLVAGVSPIIGENGQTAAVLCVLRRQAGLQA
RLAAERRLQLIVEHSNDYVLIFSPNRELSYIPPSWKRKTNVSYEEVLTFVPDD---APVVAQKLAELYDTYETQ---SAEFRKQGEKGEWVWMEAQGKAI
IDEAGTLDCVIVTVKNISERKRYEEKLRQLAYFDSLTGIANRSYFERHIHELIAS----QTPFALCYLDFDKFKWINDHFSHQAGDYFLREAVKRVERAL
RPGDFFARIGGDEFVLLLPNITKTEMTALAERLVSSFHEPFYYDKQLIQSTLSIGIAFFPKDSDRIEQVMKYADQALYEVKERGRNGYAFYRPTEH----
RQAVIEQDLPFAIMRGQLYLCYQPKVQLAKGKAMGVEALLRWRHPTLGDIPPLDFIPLTEESGFIFEITLWVLEQACRQVKEWEKK-FPGLKLAVNLSPF
LLNRPELIEHVKRILRETGLAPNRLILEVTESGLMENIETGRHILTELQRLGVQAAIDDFGTGFSSLAYIRNLPVSLLKIDRRFIQGIAENSKDATIVDT
IIHLAKSLDIEVLAEGVETESQVALLSQMDCDYAQGFYFSRSLEAEKLQQWLEEH-----
>tr|Q21SZ9|Q21SZ9_RHOFT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodoferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) GN=Rfer_3395 PE=4 SV=1
------------------------------------------------------------------RRSNRMLEAVQRSQNQLQATFDAIPDPLFVLGLD
GRYYDCRSSRADLLAAPAEDLIGKT---VSDVLPPEAASILSEANEKGTSTGKQFELQL----AHG-RAWFELSVAR-KSGQRQEPRFIVLSRDITERKQ
AEEALRIAATAFES-QEGMTVTDAQGAVLRINRAFTEITGYSADEVVGHNPRLLQSGRHDKAFYAAMWESIRRTGSWQGEIWNRRKNGEAYPELLSITAV
KENGGIVTHYVGTFMDITRRKAAEDEIRNLAFFDLQTGLPNRRLLLDRLQQALAASARHRRQGALLLIDLDNFKTLNDTLGHDKGDLLLQQVAQRLASCV
HEGGTVARLGGDEFVVMLENLSEEAAETLAKRILASLKQTYSLDGYEYQSTASIGITLFSEQQETTEDLLKRADLAMYQAKAVGRNTLRFFDPEMQAVVT
SRAALEAGLRRAVTSDEFLLYYQAQVDGQ-GHLTGCEALLRWQHPERGLVAPGEFIALAEDTGLILPLGRWVLDAACTQLAQWATRPEMHLTVAVNVSVR
QFHQADFVNQVLTVLDSTGTNPQRLKLELTESLLIGDVEDVIAKMSILKEKGVGFSLDDFGTGYSSLSYLKRLPLDQLKIDQGFVRNILIDPNDAAIARM
VIALGDSLGLAVIAEGVEIEAQRDFLARLGCHACQGYLFCRPLPLDQFEAFVRRV-----
>tr|I3YCN6|I3YCN6_THIV6 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiocystis violascens (strain ATCC 17096 / DSM 198 / 
--------------------------------------------------------------------HRQAERALRASERRFRTLVEVSQYYIQEIDTA
GTIQYANPACHALLGYRPEELIGRS---VADLVPEADRLALLHDLQSLTRDRIDVQVDWNYKRDERGPDWSDCWSQPILDHSGQVLGTFAVYAIVIEHEQ
AETAIRKAELLLESSTEGIFGLDLAGRITFINPAAANLVGFDPDELIGNAVHIHHSHADGTPLYCAMLAAAREGGNHHVHEVLWRKDGSCFPAEYWATPM
RR-DQRIEGAVVTFHDISVRRRAEAEIRHLAFHDALTGLPNRLLFKEELQQALTALRRERKRFALHLLDLDHFKDVNDSLGHPVGDELLRAVADRLSAIT
RGTDLLARLGGDEFALLQGEFKDADAAVLAGKIVENLGQDFHLNGIRIAINTSIGIVIANRQSSDVDELIAQADVALYKAKEAGRGTHAFFEDSMTLQLK
QEMDIARELSQAIKQDELLIHYQPQFDLQEGRLVGMEALVRWRHPSRGLLYPGDFIAVAEKRGLIRGLSDWVLTDACRQSRAWAEQGLDFGRIAVNLCAH
QVGDLAFGDRILEILRDTGALPGHLELEFTETVLIEATAQTQSDIVRLSELGVHFAIDDFGTGFSSLQYLRKFRTDKIKIDREFVKDVILDAGDAEIVKA
TIALGTALGLITVAEGVETEEQADFLRRHGCRQAQGYLYARPIPASDVEQRWL-------
>tr|D3RRW5|D3RRW5_ALLVD Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Allochromatium vinosum (strain ATCC 17899 / DSM 180 / N
--------------------------------------------------------------------RRQAEQALRESEQRFRTLVEVSQYYIQEIDVE
GCIQYANPASAHLLGLEPKDLIGRN---VSMLLPADERATLLKDLRTLTANGIDVEVGWNYKRDESGPDWSACWSQPIIGHAGQVLGTVAIYAIVIERDR
AENATRQAELLLESTTEGIFGLDLEGRVTFINPAAANMLGYEPETLIGQPVHIHHSRANGLPLPCPILATLQQGQDCHASEVLWRRDGSCFPAEYWATPV
RR-DHRIEGAVVTFHDISARQRAEAEIQHLAFHDSLTGLPNRLLFKEELGQALAALRRDDQRFALHMLDLDHFKDVNDSLGHPVGDELLRAVAERLTAIT
RGTDVLARFGGDEFALLQSKIGEGDAAALATKIIEAFGQAFWIDGNRIDINTSIGILIADQACHDVDDIITRADVALYKAKEAGRGTHAFFADSMTQQLR
REMEIARELIQAIQNDELFIDYQPQFDLDSGRLVGMEALVRWHHPREGVRQPAAFLPVTEKRGLIRPLSDWVLKAACCQIRDWSDRGLEFGRVAVNLCAQ
QVGDPDFGDNILAVLEQTGARPEHLELEFTETVLIAADARTQADIARLSELGIHFAIDDFGTGFSSMQYLRKFRTDKIKIDREFIQDVTQDAGDAEIVKA
TIALGTALGLITIAEGVETEEQAEFLRRHGCRQVQGYLYGRPQSPEDIERQLR-------
>tr|W0E2G1|W0E2G1_MARPU Diguanylate cyclase OS=Marichromatium purpuratum 984 GN=MARPU_07240 PE=4 SV=1
--------------------------------------------------------------------KRAAEAALRESEERFRTLVEVQQYAVMEIDLD
GAIRYVNPAAARLLGYSRDALVGMH---ATELVVTEERTRLAEDLRRLTREGIDLQVEWNYRRDAQGPFWRSCWSQPILAPDGMVLGTFAIYAIVMEHAR
VERATHLAELLLDSSTEGVFGLDPEARATFVNPAAARLLGIPAEQLTGRAIHIHHSHPDGSAISTPMLRAMREGRAYHVDAVFWRGDGSHFPVEYWSTPI
LR-EGRIEGAVVTFHDISERKRVEAEIQHLAFHDGLTGLPNRMLFKEEVDRALALLRRSGERFALHMLDLDHFKDVNDSLGHPVGDELLCAVARRISEVV
RASDVFARFGGDEFALLQVPIAHGEAAALAEKVVACFTDTFALADCAISTNTSIGIAVADRHDLDVDDLIARADVALYKAKEAGRGTHAFFAEAMTEQLR
HEIQLASELVSALEREELWLHYQPQVDLRSGALVGVEALVRWRHPERGLLHPGAFIEVAERRGMIRPISAWVLEAVCRQARAWRERGLVFGRVAVNLCAE
QVGDDAFAEQILAVLERTGARPEELELEFTETVLIQADARTQADIIRLSEIGVRFAIDDFGTGFSSLQYLRNLRADKIKIDREFVKDVTHNTSDAEIVKA
TIALGAALGLETIAEGVETEAQAAFLRGHGCHQVQGFLYARPLEPEVLERDWL-------
>tr|M2ZQR1|M2ZQR1_9PROT Putative diguanylate cyclase/phosphodiesterase (GGDEF and EAL domains) OS=Magnetospirillum sp. SO-1 GN=H261_12081 PE=4 SV=1
--------------------------------------------------------------------RGAAEETLRQREAELRLIHDTSSVAIFLTDQD
GRILDANTRMAEMFRCPHDSLMGSS---YFSHIHPDERQDGQRTIGK-LLSGPSVDIERHYRRDDGS-----------RTKDGTSRGLVGVIADITEQRK
AQTALQESEDFAFASADWIWEVDKIGTFTFVAGNVEAVLGYTPEEMIGRTAYMPADEA---AIVLKEIVARREA--FSDKNTNIHRDGSLRHILTSGIPL
FD----AAGELIGYRDATDLHAKDQKILRMAFHDMLTGLPNRALLEDRVAQALLGMTRSGDGFALLFLDLDHFKTVNDSLGHDVGDQLLVTMKDRILSAI
RKTDTLARLGGDEFVIMLTDSPGSEIRAIADKVIAEVSRPVTLHGHEFRLGASIGIAVAPEDGTAFHTLLKSSDTAMYHAKAAGRSSVCFFDKSMNARVI
RRLDMEAKLRRAIDNDEFEIHYQPKIALPDRTLCGAEALVRWRHDG-VLVPPAEFIPIAEETGLIVPLGLIVLTSVLRHIRAWRDEGLRTPRIAVNLSAR
QLFRPDLAATIFRLIAEYDLSPQNIELELTETQMMADPERAEAALSQLHDAGFSITVDDFGTGYSSLGYLKRLPIQCVKIDKSFIQDIGADSRDEALVDA
ILAIGRSMKLDVVAEGVETEEQLQFLSKRGCPQIQGYLFSRPMPEEQFR-HWE-------
>tr|A0A091B589|A0A091B589_9GAMM Uncharacterized protein OS=Arenimonas malthae CC-JY-1 GN=N790_09010 PE=4 SV=1
----------------------------------------------------------------------------------------------MDWDVR
TGEVNRSEDWYLMTGHSPDHEDARSLFWS-DRVHPADLLRFYRAFEAFQASGDTFSFNYRFRFADSRWHQMGGMARVAERANGRPVRIEIREIDLEPFF-
--AGLREEAEPVGSLLAGAWSWEPGTDEVWWSREIYELTGWDPKDPPPGLEKLYA--PESLARLQAAVRRLAETGEWLA--SAAATALRADAASLSIRTL
SGPFGIPEGARKVFLRIER-DDADPVAETRGDFDPLTGLLAFDAFLAIADAQVAA-AANPRRLVLFKINIDRFREVNALLGHRRGDLVLRAFAGHLRSNL
PEA-LLTRRSGDVFVGLLPIADGEAAGCMARI-LDITGAFEPEGLGLIKLKFRLGLVTA-DSAPSVEELVDAAAEMMSAA---GPGKAALFGPVDAARLR
RRREIYTLLPGVAGRGELQCVFQPSVSASGGELRGLESLVRWASPTIGAISPGEFIAMAEESGEIVSIGRWMLDRAIADFARMRRMGLEVPQVSINVSPA
QFADAELADFARQTCERHAVDPSRVVLEITESVLVDGSDMTSAAIDALLGAGFVLSLDDFGTGYSNLRSLIRLKLSKVKIDMSFVRRMIEDKASLIVVDT
VIRLARGLSCSVVAEGVERQEQADLLRSLGCDEIQGYLVGRPMPFGEFVAWCEGR-----
>tr|U4M5D2|U4M5D2_9XANT Xanthomonas fuscans subsp. fuscans str. 4834-R, chromosome, complete genome OS=Xanthomonas fuscans subsp. fuscans GN=XFF4834R_c
----------------------------------------------------------------------------------------------WDWDIP
ADVVYRSERWTRMLGYSEQ-PLPNNLALS-GLIHPEDHAHVSAAVQAHLEGRDTYVAEFRLRQHDGQWRWILDRGRVVSRADGRPLRMVGTHTDVHHQKL
LEQQLRDQQALEEAQSMGSWSWDSHHDALWVSQDFLQQLGITHVRLQG-IRRLLT--GPSVAQLRSAWRKIKHEGQWTE--ECYRIHGGGLPEQLELCFY
RNVQGLPPRFVALFRDITREREANERIELLAHYDRLTGLPNRFLLREQAENAIREAERG-QTLAMLLIDLDGFKSINDSFGHATGDNLLKLASARLHQHL
RNSDLFGRFSDDEFIVLLRDMSEEDAGHVARKLIAALGEPLRKEHVTLKLGASIGIALQGEGLSDFDSLLRAADAAMYAAKESGRNTYHYYSQDVLLRAQ
RRLELEHALQGALEREEFTLVYQPLVNTVDDASPAIEALMRWNRPGHGPCSPVEFIPIAEECGEIVRLGEWVIGEACRQAVVWDRAGLHFSRVAVNVSAV
QLRERGFAERVLEICRDNGWPPSRLELELTESALIRDSDSLRRCFELFEQNGVLLAVDDFGTGFSNLHYLNRFPVQRLKIDRSFVQGMLDDANTAEVTQA
IVHLGHALGMQVVAEGVETVQEDALLRQQGCDEIQGYFYSRPLSPRDMAQWLREA-----
>tr|L7HBG8|L7HBG8_XANCT Uncharacterized protein OS=Xanthomonas translucens DAR61454 GN=A989_04191 PE=4 SV=1
----------------------------------------------------------------------------------------------WDWDIP
SDKTFRSERWRQMLGYQGD-APDYGLALL-PLVHSDDQARLREAIRAHFEGRATYVCEFRLRQQDGQWRWILDRGRIVARADGSPLRMVGTHTDIHEQKL
LEQRLRDKQTLREAQSMGSWSWDPPQNRIWWSREFLRVTGLTEEHQPS-SRRLLS--RESAAQVLSTWRRMQRDGQWTE--ECYRIHGGGLPEQLDLCFH
RAVQGLPPRFVVLFRDISREREASERIELLAHYDLLTGLPNRQLLREQAETAMHDAERG-STLAMLFVDLDGFKSINDSFGHATGDGLLKLAATRMHQQL
RTSDLFGRFSGDEFLVVLRDLAESDAGHVARKLIAALAEPLHNGESVIKIGASIGIALMEDGRQDFDSLLRAADAAMYAAKESGRNTCHYYSQDVLLRAQ
RRLEIEHALHGALDREEFSLVYQPLVHAAGERAPAVEALLRWHRPGHGHCNPAEFIPIAEECGEIVRLGDWVINEACRQAAAWDAAGLNFDRVSVNVSAM
QLRDRGFAERVLELCQRNNWSPKRLELELTESALIRDTESLRRCFELFEQEGVLLAVDDFGTGFSNLHYLNRFPVQRLKIDRSFVQDMLIDSGTAKVTQA
IVQLGHALGMQVVAEGVETAQEEALLREQGCDEIQGYLHSRPLPPRELAAWLRAR-----
>tr|D2UDB6|D2UDB6_XANAP Uncharacterized protein OS=Xanthomonas albilineans (strain GPE PC73 / CFBP 7063) GN=XALc_1436 PE=4 SV=1
----------------------------------------------------------------------------------------------WDWDIP
SDKIFRSERWKQMLGYAGD-APVHGFGLL-PLVHGQDKERLQQAIRAHFEGRATYMCEFRLRGQDGQWHWILDRGRIVARADGRPLRMVGTHTDIHEQKL
LEQRLLDQQTLREAQGMGSWSWDPRHDQFWCSHEFQRVTGLNEQQVPN-SRRLLS--RDSSAQLVSIWRRMLSDKQWTE--ECYRIHGGSLPEQLDLCFH
RPVQGLPPRFVVLFRDITHEREANERIELLAHYDLLTGLPNRQLLREQSEKAMHDAERG-STLAMLFVNLDGFKSINDSFGHAAGDALLKLAASRMHQQL
RTSDLLARLSGDEFVLVLRDLAEGDAGHVARKLITALAEPLPNGENVIKIGASIGIALMEEGRQDFDSLLRAADAAMYAAKESGRNACHYYSQDVLLRAQ
RRLEIEHALHGALDREEFSLVYQPLVHTVEGHPPAIEALLRWYRPGHGHCNPAEFIPIAEECGEIVRLGDWVISEACRQAAAWHEAGLSFDRISVNVSAM
QLRDRGFAERVIELCQRNGWSPKRLELELTESALIRDSESLRRCFELFEQEGILLAVDDFGTGFSNLHYLNRFPVQRLKIDRSFVQDMLHDSGTAKVTQA
IVQLGHALGMQVVAEGVETVQEDELLREQGCDEIQGYLHSRPLPPRELAAWLRAR-----
>tr|A0A023Y3G2|A0A023Y3G2_9GAMM Histidine kinase OS=Stenotrophomonas rhizophila GN=DX03_10310 PE=4 SV=1
----------------------------------------------------------------------------------------------WDWDLP
SDAVIRSRRWDDQPVPAEEVTRGDVTALL-APVHPDDQAAVRAALDAHLRGDEVYTAQYRLRHPDGDWRWVLDRGRVVARADGQPLRMVGTHTEIQAQKQ
LEAQLLEQQVLREAQSMGSWSWDPAERQFWWSPEFRALLGVGEDPLSG-RRRQLE--PRSRSLLRHAWRRMLRDGQWTE--ECYRIHGGGLPEQLDLCFY
RQVQGLPTRFVVLFRDITREREANERIELLAHYDLLTGLPNRMLLREQTADAIEEADRG-APLAMLFIDLDGFKTINDTFGHATGDALLKAAASRLHQNL
RNADLFGRFSGDEFIVVLRDLADEDAGHVARKLIASLAEPLQRGETTLKVGASVGIAMLDQSHHDFESLLRAADAAMYAAKEAGRNTYQYYSQDALAKIQ
RKLEIEHALLGAIEREEFTLAYQPLLHAENDQPPAIEALLRWHRPGIGYCSPAEFIPIAEKCGEIVRIGDWVLAEACRQAAAWDAAGLAFDRVAVNVSAV
QLRDRGFAERVIDICHAHGWPPQRLELELTESALIRDTDVLRHCFDVLERHGVPLAVDDFGTGFSNLHYLNRFPVGRLKIDRSFVQGMLHDTGTAEVTQA
IVHLGHALGMKVVAEGVETEQEEAMLRRQGCDEIQGYLYSRPLTPRDLAQWLKTG-----
>tr|G0JZG7|G0JZG7_STEMA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Stenotrophomonas maltophilia JV3 GN=BurJV3_1970 PE=4 SV=1
----------------------------------------------------------------------------------------------WDWDIP
SDRVARTPALGD-----------ETAEML-SRVHSEDIAQVRAALDEHLRGREQYSAQFRFRQADGQWRWVLDRGRVVARADGQPLRMVGTHTDIEQQKQ
LESLLQEQQLLSEAQSMGSWSFDPNSGHFWWSPELRSLLALEQGAVPG-QRKQLH--PRSRGALRAAWRRLWRDGQWTE--ECYRIHGGGLPEQLDLCFY
RQVQGLPPRFVVLFRDITREREANERIELLAHYDLLTGLPNRVLLGEQTAEAIEEADRG-TSLAMLFIDLDGFKTINDSFGHATGDALLKAAATRLHQNL
RNNDLFGRFSGDEFIVVLRDLAEEDAGHVARKLIASLAEPLRRGETTLKVGASVGIAMLGDAQTDFDSLLRAADAAMYAAKEAGRNTYQYYSQDALARIQ
RKLELEHALHGAIEREEFSLAYQPLLHAHQGEPPAIEALLRWHRPGIGYCSPAEFIPIAEKCGEIVRIGDWVLNEACRQATAWDRAGLRFDRIAVNVSAV
QLRDRGFAERVIEICHAHGWPPQRLELELTESALIRDTDILRHCFDVLERHGIPLAVDDFGTGFSNLNYLNRFPVGRLKIDRSFVQGMLHDSGTAEVTQA
IVHLGHALGMKVVAEGVETHQEEDLLRRQGCDEIQGYLYSRPLSPRDLAQWLRQQ-----
>tr|A0A0D0JL37|A0A0D0JL37_STEMA Stenotrophomonas maltophilia strain ZBG7B contig_47, whole genome shotgun sequence OS=Stenotrophomonas maltophilia GN=SN15_1108
----------------------------------------------------------------------------------------------WDWDLA
SDRVLRSPPVEGRI------EVQERAALL-ERIHPDDRAGVHAQVQRHLRGEDQYSAEFRYRQPDQSWRWVLDRGRVVARADGQPLRMVGTHTDIEHQKQ
LEAHLHDQQLLRQAQSMGSWSWEPGCRRFWWSAELHALLGTAGDPSFS-PRRRLQ--PRSRGALRMAWRRLWRDGQWTE--ECYRIHGGGLPEQLDLCFY
RQVQGLPPRFVVLFRDITREREANERIELLAHYDLLTGLPNRMLLREQTTDAIEEADRG-TPLAMLFIDLDGFKTINDSFGHATGDTLLKAAASRLHQNL
RNSDLFGRFNGDEFIVVLRDLAEEDAGHVARKLIASLAEPLHRGQDLLKVGASVGIAMLEDGREDFDSLLRAADAAMHAAKEAGRNTYQYYSQDALSRIQ
RRLDIEHALHGAIEREEFSLVYQPLMHAQPGQPPAIEALLRWHRPGLGYCSPAEFIPIAEKCGEIVRIGDWVLNEACRQASAWDRAGLLFDRIAVNVSAV
QLRERGFAERVIEVCHAHGLSPTRMELELTESALIRDTEVLRHCFDVFERHSVPLAVDDFGTGFSNLHYLNRFPVGRLKIDRSFVQGMLEDAGTAEVTQA
IVHLGHALGMKVVAEGVETEQEEDLLRRQGCDEIQGYLYSRPLVPRELAHWLRDA-----
>tr|E6WST9|E6WST9_PSEUU Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudoxanthomonas suwonensis (strain 11-1) GN=Psesu_1529 PE=4 S
----------------------------------------------------------------------------------------------WDWDIG
ANRIFRSETWRAMLGFTAEDAPDSSLSAM-AMVHPEDVERVREALRAHLDGRDAYTCEHRLRHCNGSWRWVRDSGRIVAWADGRPLRMIGTHTAIDEQKQ
LEERLRGQQALEEIQGITSWSWTPGVDVGWWPREFYRLLGHPPRDRDS-ARRRLP--REAASALRRAWQRMRRDGQWTE--ECYRIHGGGPAERLELCFY
RPVQGMAGRFVALFRDISRERETSERIELLSHYDLLTGLPNRFLLRVQVEEAIADAASGDASLALLLLDLDGFKNINDTFGHAAGDAMLKAVAGRLHMAL
AQGDLFGRLGGDEFMVMLRADAA--AEAAGLKLINALSEPLPFGGELLKAGASVGVSVLGADGTAFDELLRAAHSALRVARERGRNTLQMHDAEIHRQTR
RRLEIEHTLRGALEREEFSLVYQPQISITDRHAPGIEALVRWHRPG-GTCHPGEFIPIAEQSGEIVRLGEWVIAEACRQAVAWHAAGLDFGRVAVNVSGV
QLRDRGFAERVVALCQRAGWPPARLELELTESALILDSESLRHCFKVFERHGIQLAVDDFGTGFSNLHYLNRFPVQRLKIDRSFVSGMLHDANAGGVTQA
IIHLGHALGMRVVAEGVETMQEQEQLRLWGCDEVQGYVHTRPLPPRELAQWLRQA-----
>tr|A0A091BSQ1|A0A091BSQ1_9GAMM Uncharacterized protein OS=Arenimonas malthae CC-JY-1 GN=N790_07955 PE=4 SV=1
----------------------------------------------------------------------------------------------WDWDSE
SGQVYRSGRCFSMLGYSRD-ALDGSFAWQ-SLIHPDDKPRVKAALHAHLAGEENYQVDYRVRDANGRWRWILDRGRAITWASGRPRRVIGTHTDIHDYKH
IETQLRERELLNQAQHLGSWSWDPETDQLWWSDELYWIVGLSRRKPPPSFRHLFT--PESYGRLHEASVALLKHGHWTD--ENYRIHGERVPETVEACYF
TPLRGRPYRITGLTQDVTEEHEAGERIEQLAHYDTLTGLPNRFLFRQTADEAIELARSG-KPLALLFLDLDRFKYVNDTQGHEAGDQLLQEIASRLRACV
RASDLVGRLGGDEFLVLLREVAREDAALVARKVIDAIGQPIQLPTGDAQVGCSIGIALLGEGNSDLESLLRSADTAMYAAKDAGRNTYQFYNSSFYERVQ
RRVTLEQELRQALAHDEFQLAFQPTMSLRDGGVACIEALLRWTTRAGVQRSPVEFIPVAEECGEILPIGRWVLGEACRQARRWHEAGLAFGRIAVNVSPL
QLRDPEFATQVLAICEREHWPTDRLVLEITESALMRESEVLANAFALFKANGITLSIDDFGTGFSNLGYLHRFPLRNLKIDRSFVSQMETSPNMLELTHA
VVSLGHALGLAVVAEGVETESVLQLLRQQGCDEAQGYLFTRPLPGAELATWLAAQ-----
>tr|A0A091AYJ2|A0A091AYJ2_9GAMM Uncharacterized protein OS=Arenimonas metalli CF5-1 GN=N787_13935 PE=4 SV=1
----------------------------------------------------------------------------------------------WDWSGD
TGRVYRSARCLSMLGYPPD-YLPDNLSWR-DLVHPDDRPRVADALSLHLDGQEGYQSVYRARDASGGWRWILDRGRVIEWLDRKPRRVIGTHTDITEYKL
IEQQLREREVMNQAQRLGSWSWDPDTDAIWWSDELFVIAGLPADQAPPPFRHLYE--PESYERLKEASRRTLATGQWTD--ENYRIHGGSSEETLEVTYF
TPLRGQPHHITGLTQDITEEHEANEQIEQLAHYDTLTGLPNRFLFRRRALDAIASVNGE-PPLALLFLDLDRFKNVNDTLGHEAGDRLLQEVAGRLRQCV
RGSDLVGRLGGDEFLVLLREVGREDAAYVARKIIAALSQPVLLGEHEAHVGCSIGIALLNEGSPDLEALLRSADTAMYAAKDAGRNTFQFYNDSFYEKVQ
RRVTLEQELRQALARHELSLVYQPTLSLRDGRVAGIEALLRWRTTAGDSRSPAEFIPIAEECGEILAIGRWVLGEACRQAREWHEQGLVFDRIAVNVSAV
QLRDSQFATDVLEICARNRWPTDRLELELTESALMRDTDVLRRAFDLFSANGICLAVDDFGTGFSNLAYLHRFPVRHLKIDRSFVQQMGEGARLRGLTQA
VVSLGHALGMEVVAEGVETEAILAMLREQGCDQAQGYLFTRPLEPAALGTWLRAQ-----
>tr|A0A087MGN3|A0A087MGN3_9GAMM Uncharacterized protein OS=Arenimonas donghaensis DSM 18148 = HO3-R19 GN=N788_05690 PE=4 SV=1
----------------------------------------------------------------------------------------------WDWDAE
RDQVYRSGRCFTMLGYSRD-AFAGSFAWQ-GLIHPDDRPRMKVALHAHLTGEENYIVDYRVRDANGRWRWVLDRGRAITWSVGKPQRVVGTHTDIHDYKQ
IEAQLRERELLNQAQHLGNWSWDPENDRLWWSDELYWIVGLSNTQSPPKFRHLFT--PESYARLHAASVALLKHAHWTD--ENYRIHGEHVPESDELCFV
TPLRGKPYRITGLTQDITEEHEAGERIEQLAHYDTLTGLPNRFLFRERALESIELARTE-KPLALLFLDLDRFKYINDTQGHEAGDLLLQEISGRLRQCV
RASDLVGRLGGDEFLVLLREIAREDAAVVARKIIDAVGAPMELASGEAQVGCSIGIAILGENSADLEALLRAADTAMYAAKDAGRNTFQFYNASFYERVQ
RRVTLEQELRQALARDELHLAFQPTISMKDNAVACIEALLRWTTTAGEARFPAEFIPVAEDCGEILPIGRWVLGEACRQARQWHEAGLVFGRIAVNVSAL
QLRDPEFANHVIEACEREQWPTDRLVLELTESALMRESEVLRNTFAVFKAHGITLSIDDFGTGFSNLGYLHRFPLRNLKIDRSFISRMDTAPNMLELTHA
VVSLGHALGLSVVAEGVETENVLQLLRQQGCDEAQGYLFTRPLAGEDMATWLAAQ-----
>tr|A0A091AZ26|A0A091AZ26_9GAMM Uncharacterized protein OS=Arenimonas oryziterrae DSM 21050 = YC6267 GN=N789_08145 PE=4 SV=1
----------------------------------------------------------------------------------------------WDWSAE
GGRVYRSPRCLTMFGYPPD-YLHDTVAWS-ELVHPADLEMQKNAIGQHLAGNSTYKVEYRIRDFHGQWRWVLDRGKVIEWTDGRPKRVVGTHTDITDYKD
LELRLRERELLDEAQKIGSWVWDAASDIFTWSDELYRICGWPMDQRPPRWAALFT--PESYTRLTTMVEAAIKSNQWTD--ENYRIHGGESTDTAEVNFI
TPLRGRPYRITGLTQDITREREAGQRIEQLAHFDTLTGLPNRFLFRQRADEAISVARAN-LSLALLFVDLDRFKDVNDTHGHAAGDQLLQEISGRIKACV
RGSDVVGRLGGDEFVVMLCEVRKEDAALVADKIIAAVNEPVALPDGEVTVGASIGIALLNEGTVDLEALMRASDAAMYAAKQSGRNGYQYYNDAFYERIQ
RRVQLDKELRLALTRDQLFLVYQPTVALGSGTIQSFEALLRWRRGNGDLCSPVEFIPVAEESGEIVPIGRWVLREACRQAVVWRHTGLPFERIAVNVSAV
QLRDPEYATQVLAICQETGWAPEHLVLELTESALMRDNEALRRTFTLLESYGVRLAVDDFGTGFSNLHYLHRFPVQHLKIDRSFVSQMLGDLQVTVLTQA
IIHLGHALGLTVVAEGVETDQALQALRAQGCDEVQGYLLTPPLPPPELEAWVRAR-----
>tr|B2J5P2|B2J5P2_NOSP7 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=N
----------------------------------------------------------------------QAEEELRRSETLLATAQKIAHLGSWEWHLG
SEKQIWSAETFRIFGLNPAESVPTQATFL-QMLYPEDRPVLQRHLLQAIANGNPFNLEYRIVQPDGSLRYLESRAEVAYDTQGKTVRLYGAILDITERKQ
AEIALKQSEIRYRAIVEFIARYLPDGTITFVNQAFTRYFGRSPEQLIDSNPVILEDSVRWTQWHNRMLFD-EQGCFIEFTLFQEKEKGVLLEEVFRIAPI
RNREGQVIGAVMVFHDVTQNRLLSRQLSWQATHDALTGLVNRQEFERRVEQALHVAKLDYQVYTLCYLDLDHFKIVNDTCGHVAGDELLRQITVLLQEKV
RKTDTLARFGGDEFGLLLTQCTLEEALRVANNLLSCVQEFFVWQEQVFSIGVSIGLVVIDTNSESLAEIISTADAACYTAKNRGRNRVYVAQTDDQERLQ
QRMQWVGRISQALESDWFCLYVQRIIP-TDQNGDHYEVLLRLRDEQGKLVLPMAFIPAAERYNLMHLIDRWVIRTLFK---NWSRVVDNKSIYAINLSGS
SINDDRFIDFLHEQFTLHPISPQHICFEITETVAIANLLKARQFIQKLQRMGCRFALDDFGAGMSSFAYLKSLPIDYLKIDGSFIRNIVENPVDNAIVTA
ITRISSVMGIQTIAEFVENDAILERITALGIDYAQGYGIAVPHPLGKI------------
>tr|W0SCS6|W0SCS6_9RHOO PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Sulfuritalea hydrogenivorans sk43H GN=SUTH_00755 PE=4
----------------------------------------------------------------------QAERELLHLHERFSLALKTVGLGIFDWDAK
EDKLLADARVFEIFGVSPNGRNNRFNDWT-DYLHPEDREQTLARIAMLRAKEADFKLSYRIVRPDGEIRHLEVHNHIVRDASGRTLRLIGADFDVTERKR
TEERLRLTEQVFDHSPVAIVITDSENRIISVNESFVRISGYGESEVLGRDPKFLASGLHNAEFFERMWQALQEGDFWEGEVWDRRKTGEIYPKWMTINVV
RDEDAGRMHYVAIFSDITERKQAEEHIHHLAHHDPLTTLPNRMALEARLEQSIAEANRNQRSVAVMFLDLDRFKTINDTLGHHVGDLLLIEVARRLRQTV
RSSDTVARHGGDEFVVVLPALETPDAATLAGNILKTLSEPYLIDGNTLHSTPSIGVSLYPQDGRDVDTVMKYADTAMYHAKDMGRNGFQFFSPEMNRAAM
ERLDIERQLRDALKLDQFALHYQPRLD-RNGRVTGVEALIRWNRPGHGLQPPGRFIPIAEESDLIILIGEWVLATAAAQLVAWQKAGIEMPSVAINLSAR
QLRLAGLPGQIAAVLQDSRLPAALLEFEVTETMAMENPERASRLLGELRDMGIALAIDDFGTGYSSLAYLKRLPFDHLKIDRSFVAGIAHDQNDVAIVRG
TIALAHSLGLTVVAEGVETAEQLALLKSADCDEFQGFHFSRPLPADEL------------
>tr|E6Q2H9|E6Q2H9_9ZZZZ Uncharacterized protein OS=mine drainage metagenome GN=CARN4_0647 PE=4 SV=1
----------------------------------------------------------------------TTERARYESARRLRSLFEANPDGVIAVDRS
GRITEANAASARIGRYEIDAIIGRN---FEDFL-TDAYSTRRQFATAIAGEGCSFALE-G-YRIDGSIVPLDITLIPQYSG-NAIIGVYAVLQDITLRLE
AQERLRLGCRVFEAELGVVIDTTRRTPRIEASTNASRQEELD-PKLAAFAQRILGDGIDASPLITPE--ALA----VPIDVAGERFGAAIFSQISQSRTF
TETDAEFLGLIALLQSFIERGRVRVHLQRMAYVDVLTGLPNGSGFRDRLRLAIEAAPLRMQRVAVLFFGLDRFKDINETLGHRLGDRLLQALGTRIDGLF
STVGIVARMGGDEFAIMVQDAGTDRLRDLAEQIIAAVEEPFQVDDFEQFLSASIGIAVYPEDGTHVDSLVKNADIAMSRAKDRGRGGFYFYNATLESPIL
MRLSQERLLRRALERNEFLVYYQPQIDLTDGTIVGLEALVRWNHPGSGLIEPGHFIPSAEISGLIVHLGRWVLETATMQASAWVRRF-GPLRLAVNLSAR
QLHHRHLRQEILGALDLSGLDPVLLELEITESVAMSDVEQAIAIVREMKGSGVRTAIDDFGTGYSSLAYLRRFAFDVLKIDGSFVDGLGQEREDETIVKT
LVGMANSLGLETVAECVERNEQALFLRDYGCRFAQGFLYAPPLPASEIEALLQSK-----
>tr|U5N8V2|U5N8V2_9BURK Signal transduction protein OS=Candidatus Symbiobacter mobilis CR GN=Cenrod_1887 PE=4 SV=1
-----------------------------------------------------------------------AEQAREQERRLYDALLDATDNPIYAADLE
GKMLLVNQALLQLLQRPRDAVLGHT---RESFQ-PLALHR---ADQQVLQSGVPTTFEER-IHPVGESDPIDFVRFPLYDRAGKAYGVGGIATDVSA-LK
AQQRLLLSESVFQNSDQAIIVTDAQMHIIRVNAA-FRMTGFSAEAVLGQHTRVLKSGRHSPAFYESIGRSLMQTGHWAGELNNRRADGSFFTVWSNISVV
RDSEGQVMHYIALQSDVTQLHEAQIALQRQASYDGLTGLPNRDLFNDRIAQLVAQSQRQQSQFALLFVDLDHFKEVNDTLGHQVGDILLRTVSERLQRGV
RSEDTVARMGGDEFVILLPNTDRGAL-SLANNLLVRLREPLVLEGAGSYPMASMGVSVFPEDGRSPDELLRSADMAMYRAKMTGRNRMLSYTADMGASND
LAFTIQTELAIGLVEQQFRVYYQPKCMLNTGELVGAEALVRWDRPGHGITLPGVFIGVAEKSGLLVELDHWVMQDSLRQLGEWLRAGLPTMRMAVNQNVA
DLQRSDLLDQINALLQASGVGPEMLELEITEDALLHHTSEQLERLQALRSTGVSVAIDDFGTGYSSLSYLRLLPVSVIKIDQSFVASMLTDANDAVLVRT
IIDMAHDLGHSLVAEGVETPMQCERLCELGAEVGQGYFFGYPVSAEEFEQRWLRN-----
>tr|D5XDZ1|D5XDZ1_THEPJ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thermincola potens (strain JR) GN=TherJR_0997 PE=4 SV=1
---------------------------------------------------------------------------------KIEAIVAGIGDGISIQDTN
YRVIFQNRIQRELMG----EAVGQY-CYQRDQVCPGCP------VAVSLQEGTIQTVERCPELKKGS-LYIEVTSAPLKDAAGKITGAIEVVRDITERKK
TEELLRQQSAAMRASMDGMAILNTNGEYIYMNEAHARIYGYANPAQIGKTWHILYDEEERDRFEKEVLPALYKQGYWTNEVVLIHRSGRRYAIEDSAAPI
KNREGEIIGVVLVFHDVSEKRNMIEQLTHQAYHDPLTDIPNRVLFNDRLNVALAHAKRNNEMLAVMFLDLDRFKLVNDMLGHSIGDRLLQEVAKKLSICL
RKGDTIARLGGDEFTLLLPQIKSKEAAKIAQKILKAFQKPVTLSGHEFYITASIGVALYPSDGEKAEILMKNADTAMYRAKEQGRNTYQLYTPAMNKKIV
ERMAMENSLRHALERRELVVYYQPLVCIRTGRITGMEALIRWRHKELGLVPPAEFIPLAEETGLIIPIGEWVLRTACAQNKAWQDAGYMPVRVTVNLSAY
QFQHQNLVNTVAKTLKQTGLHPQYLELEITESIAMQDVDYTVDVLRKLREMGVQIAIDDFGTGYSSLRYLKRFPINTLKIDRSFVRDIACDPNDAAIVST
IIVLCRNMNLKVIAEGVETEEQLNFLKNQHCYEMQGYFFSQPVPEKEFEELLKRYNMP--
>tr|A6W8B5|A6W8B5_KINRD Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Kineococcus radiotolerans (strain ATCC BAA-149 / DSM 14
---------------------------------------------------------------------------------------------------A
TRVRWANTAAADLFGVAADHLVDLA-TT--RLLRPRDGSP--E--LERLSRDRRTRCAVDAVTSGGELRRTEVVAWPVPEEGWEWFWVLGVVLPQAALRA
AEDRFA---TLAQSSPVPTIVSDVGARLSRVNDAFAELIGLPAEELCGTAWTHVVDDERSG-VVEAVARVLSG--ERVTDTRLRNAAGQVRWVAVRLAP-
SRTPGYGAGFIGTVEDVTDRLAREHRLAYQAQHDLLTGLPNRLALLERLADLLALPGEPGTDVGVLMVDLDDFKTVNDGLGPEAGDAVLVEIARRLAGTV
RSGDVVARPGGDEFVLVCAGLDDGAVEATARRVLDAVLAPVEVNGLRLRLSASIGVVLLDGSSCGPEEVVRDAGIAVHEAKAAGGGRWTLLDEDVRHRAR
RALRLVADLREALSRGAVDVHYQPIVRPGPAQVLSLEALCRWTHPELGAIPPDTFIELAERANLVPALDAHVLAVACRDLATWRHAAGD-LPVAVNVSAV
SLAAEGFAAGVRRTVAGAGLQLSDLCLEVTETALASDLRACRTVLEELRRDGARVAIDDFGTGYSSLAYLKDLPVDHLKVDRSFVRDLRTAVDGRAVAAA
VVSLARTLGLGIVAEGVETLEQDAVVRDLGCEAVQGWLYSRPLPREALAELLRGGG----
>tr|I4ESE3|I4ESE3_MODMB Str. BC501 chromosome, complete genome OS=Modestobacter marinus (strain BC501) GN=MODMU_0856 PE=4 SV=1
---------------------------------------------------------------------------------------------------T
-----AVFRAACL---AAGLVLGGA-NW----LLARSVIG---T-RLRLLAGR--IGEVAQ--TVGD----PVTSAQGPGPAADLALPVDSALGFNAALD
RERRFR---SVVHATNDVLALLTPEGRVAFVSDSTSAVLGWTRAELLEMHADLLFAEDAHL-FTTSGAP----IG-QPSVFLVRVRHRDGGWRHLEVSSS
RRDDPDIGGLLLTARDVTERLELQSRLAHQATHDALTGLPNRAAVLARGEELLTDPATP-CRLAVLLMDLDRFKEVNDTLGHSYGDRLLAQVGPRLRPLV
REVDMVARLGGDEFAVLLPDVTV---RAAAERLHAALGTPFLVDGLSLDVDVSIGVAVCGEGGADVGTLLRQADIAMYAAKESH-DGVAVYDPLSDGNDR
SRLVLLSELRRGLADGELVVHYQPKVALGSGQVVGVEALVRWQHPVRGLLAPVDFLPAVERTALIEPVTDAVLDLALAQVRAWWAAGFR-VPVAVNLSAR
SLARPDLLGRVLQRLQAHGVPADLLRLEITESALLAEPTRAREVLRSLHAAGVRLSIDDFGTGYSSMGHLKHLPVDELKVDRSYVAEMVTSAEDAALVRS
VVDLGHELGMTVVAEGVEDAATAAALADLRCDVGQGWLFGRPGPAVDVTAVLRAGA----
>tr|M5A853|M5A853_9ACTN Uncharacterized protein OS=Ilumatobacter coccineus YM16-304 GN=YM304_42700 PE=4 SV=1
---------------------------------------------------------------------------------------------------N
GEISSANARASALTGRSVDDLLGRS-FL--GFVAADDQDDIDRWERLRLGVDAEPVFELVDRSGVGHLVEATLHQRHDPDNGGTVVIL-RDVRETKA-EA
ARRRFQ---LAFHSAPTGMALVRLNNKIVDANQSLADMLDHSRRYLLGRSIEITHPDDLRA-AAAERARIELGIGYQVERYLRRD--GAYVWAKTRVAVS
---DDGVSLAITHIEDVTEQRKAVEDLAHAATHDSLTLLPNRASIVARLDELLVTAGTD--EVAVLFLDLDNFKVVNDSLGHGVGDELLRHVASRFRSVM
REGDQLARFGGDEFVVFVDGTSRGEIASVAERLQRSVQDAVVIGGHELVVTTSIGFATNKRAGMSAEDLLRDADTAMYRAKAAGRDRIAAFDDRDRHSSV
LALQTANDLRRALATDEIVPYFQPITDLQTGDITSYEVLVRWLHPEQGLLGPGKFLPTAEANGMMGEIGERMLRDALAQLARWRDAAGR-AAISVNLAAQ
QLSDPNFVAVVDDALATSGIEADSLWFEITETALLTDVGVATTALRELRGLGVHLSVDDFGTGYSSLTYLKKFPVEAIKVDKSFVDGLGIEVDDSSIVDA
VVRLGHSLGLSVIAEGVETPLQLRMLRELGADKVQGYLFGRPMPARLVGQSTFAEH----
>tr|I1XKK4|I1XKK4_METNJ Methylophaga nitratireducenticrescens strain JAM1, complete genome OS=Methylophaga nitratireducenticrescens (strain ATCC BAA-24
-----------------------------------------------------------------------------------AFILDASYDSALELLLN
ELIDFTDSAFGLIGDVRYDA-NQAP---YLKVIQSNGKHNLDSV----MASGKVINNSPNDEAQPCQPKFTSCLGLPFSHTIKRLSPILATLESLYEARK
MSRLRRQNEVLLQRSADAMGIIGKEMIITECNDAAAKLYGFARQELIGLSPLDISPVSQP-AGYSSDISKALTEGYQRFEWLHHTAQSETPIVTLTPVIF
HDETCIQ----VVWRDLTDIKAKEHRIKQLAYFDELTGLANKNLFADRVKHLLQLSKRYNYTIAVVYLDLVNHEDIQETLGYIAGDTLLHAVGQRITSII
RSTDSLARINGDVFALAAV-VSSDAVEIMVTRLQNTLKAPFSISDSKVMVNTRTGIALYPQDADNFDALTRGAAIALHIAKEKLLSSY-FFNVRLGEEIH
RHSLIAKRLEYSLDPNSFSIRIQPQVNLQTMNLSGAEILLRWDDSSLGSIPPNIFIPIAEERGLINEITKLVIQLTSHALLSWKKQGYAVIRMAINISAK
SFNNLIFVEEFIADIKDSGLTPEDFELELTETGIMHDPELAIEIIKQLKLEKFVLAIDDFGMGHSSLSYLRNIEADILKIDMFYIKNMLTDKKNMAIVKT
IISTAQIFDMKTLAEGIEDQETLTELKRLGCDYAQGYFVSHPLTINDFEEWIKQKQGT--
>tr|B7X4G0|B7X4G0_COMTE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Comamonas testosteroni KF-1 GN=CtesDRAFT_PD1712 PE=4 SV=1
--------------------------------------------------------------------------------------------GTLVVTDE
LNVVFANQAFAQLAGQTPMALKGDP---LPVFMDVGSLPAVKQA----LQHQHRGRSQLHFHAQALAIVSITVHSLQQPD----QPRLLITVEDLRKQEQ
L-RDLLN--------AQEVANIGT-DGKPSLTPQAARILGWP--------------VGQP-FKYADLWKKGLATGHYAFEMR-IQDGTSVRWVDALGTIE
HDVTGKPVRGYGTLLDITERKRTERRMEKLAFFDALTGLPNRFHGIDLAQRLLDIAGQRGQQATVLFVDLDRFKEINDSQGHLVGDDLLAEVARRCERTL
GGEGVVARLGGDEFMFVRT-LAENDTMALAHEVCSTLASPMRVDDLCFEVGASVGVALYPTHGHSVDELLQRADIAMYQAKTQGGGNCQLYDAQMGHRLQ
RRIALGVKLEEALAQSRLELHFQPKIALDSYALYGVEALARWHDEEWGWVSPAEFISVAEERGLIIALGDWSLDAAARQWRAWSSAGIAPPVIAVNVSAA
QMMSDSFSERALAIMRAHGVSPRCIELEITESALMHDPAKAKRVASQLVEQGFTLSIDDFGTGYSSLARLQSFPVSRLKIDMSFVRGMLSEPGSLAIVTA
VIGLAHALKLRTVAEGVETQSQLDKLRDLHCDEVQGYLFSKAVPAAELADWLTL------
>tr|A0A0A1VBV3|A0A0A1VBV3_9BURK Uncharacterized protein OS=Acidovorax sp. MR-S7 GN=AVS7_00523 PE=4 SV=1
--------------------------------------------------------------------------------------------GTVVATAD
LDVVFANEAFAHLAGCAPEALVGHP---LGALMDVGGLPAAQQA----LLHGHRGTVQLRPRAQALALVAVTAHTLQ-PG----APRLLLTIEDLREREQ
L-RDLLN--------AQEVANIGT-DGRITLTPQAARILGWP--------------ESQP-FGYGDLWADGLARGHHAFSLR-VRHDGQVRWVDLRGRTE
HGAAGQPVRGYGTVLDITERHHTEQYMQRLAFFDTLTGLPNRMHGMKQVQRLLHEAGEQKQRAVVLFADLDKFKEINDTQGHAAGDRVLVAVARYCQDAL
DTGGVLARLGGDEFMFAHP-LADEDVLALARQVHAALQRPVWVDGLRFEVGASIGVALYPAHGQDVDELLQCADMAMYRAKMQGC-GCLLYDEALGRQVQ
RRIALGTRLEAALQQSLLELHFQPKVDIASGRIVGVEALARWHDAEWGWVSPAEFIAAAEERGLIMALGDWSLDAAARQWRAWRDAGVTPPPIAVNVSAT
QMMGDAFAERALALVRAHGVRPQAIELEITESALMLHPDRARRVASRLVELGFTLSLDDFGTGYSSLARLRDFPVSRIKIDMSFVHGMLAEPGHLAIVTA
VIGMARALGLRTVAEGVETQEQRHRLHALQCDEVQGWLFGRAMPAAELERWLRPAPLP--
>tr|A0A0D7K7L1|A0A0D7K7L1_9BURK Diguanylate cyclase OS=Acidovorax temperans GN=RP29_13805 PE=4 SV=1
--------------------------------------------------------------------------------------------GTMVATSD
LKVVFANRAFENLFGFSPSNLRGCP---LSNVMDVSHISAIDAA----MRQQSRETLEVRPHHNPLAVVSITAHTLPKTE----EQRLLLVFEDLREQTQ
L-RELLN--------AQAVANIGT-DGAITLTPQAARLFGWP--------------MTKP-FTYAQFWNAGLRLGRFRFECR-VQSSPRVRWVEMRGVIE
KGRTDQPIRGYGTVLDITDRKTTEHAMERLAFYDSLTGLPNRTNGMMLAQQMLDQARQAGVAVAVLFVDFDRFKEINDTHGHIVGDNVLSELAARFRSAC
AKNDVFARVGGDEFMRAYK-LAPEDPLERAKQLQHALGLPVVFDSLKFEVGASIGVALFPEHGDSVEDLLKYADIAMCDIKGRGG-DSLLFNEALALKLE
RRISLGAKLAHALAHSQLQLHYQPKVHLATGTLCGVEALSRWCDEEGQWISPAEFIPVAEERGLINELGDWTLVQAARDIRYWQEAGATVPRVAVNVSAA
QMMDEGFAERALHLVRAQGVEPSMIELEMTESALMNEPEKARHAASRLVQAGFCLSIDDFGTGYSSLERLQSFPVFKLKIDMSFVRDMDTHAGNRAIVTA
VIGMAKALKLETVAEGVETAAQAALLAELHCDEAQGYLYSKALSPQVLLRWLQQPSTE--
>tr|A0A063BDJ4|A0A063BDJ4_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. lig30 GN=LIG30_0174 PE=4 SV=1
--------------------------------------------------------------------------------------------GTLVVSPD
LRILFANRACETLFDIKPEQLCDVS---LDRVMAVDVLRDIARA----LHEPKRAETALRDRPAQLAVVALTVTKLPLGQ----DERLLIVIEDLRKQTR
L-KDLLN--------AQAVAGIGNMTGKVTLSPEAYRIYEWP--------------QDET-FDRASFWDIALTGKPLKIEHR-VNIAWAVRWVETRGVIE
RDASGRPIRGIGTVYDITERKLAENDIERLAFYDTLTGLPNRSQAMIQLQRTLDAARASREQAAVLFIDLDRMKEINDTQGHATGDEILRHVGERLGAVL
HEGETLARLGGDEFIAILG-PTSAAAAETAARLLKAITLPFAVNGMSFTIGMSVGVAIFPDDGESADNLLRHADTAMYCAKAQGGRASLFYHPRMSDDVQ
RSVALGRRLEVAIKEQRLHLNYQPKICLATGTLSGIEALARWVDDELGPVSPAEFIPVAEERGLIGALGDWVLAEASRQVCRWRRAGFDPHRVAVNVSTW
QLADEDFVRRAIAQVEQAGVHTSSIELEITESMMMHDPKKARDMAEQLVGAGFSLSIDDFGTGYSSLAQLKHFPIDRLKIDQSFVRDMSDDPASRTIVKT
IIGMAKALHLRTVAEGVETRAQSDDLLHLGCDEAQGYYVARPMSAQEFTRWLSRAA----
>tr|H8GJY7|H8GJY7_METAL PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Methylomicrobium album BG8 GN=Metal_0076 PE=4 SV=1
--------------------------------------------------------------------------------------------GLCVLASD
FTVLSANRAFLDRFDLSKANLRGRS---LLAVIAADGLGALSEV----CDSGMQHDLLFERVGESTRHVRVTLSGMRLEE----A-RLLVVVEDITEQV-
-QATLLH--------AQEITHIGSKTGVLTWTPEVGRLFDLPD-----------PPQDTP-ISYDTFWQAAIKGVPYRIQHR-IVARGETRWMEERVALV
FDDDCQPVRAVGTVQDITEHKAAEIRIENLAFYDMLTGLPNRALFMDRFKHELAAAERRAQRLSLLFLDLNRFKEINDTLGHDTGDRVLSEVAHRLRLAL
REEETLARLSGDEFVIIAS-DSS-AASHIAERIGRAFSAPFLINGQSFAISASIGIAIFPEDGRSTEELLKHADIAMYRAKGGGGGYC-FYSAEMGEALV
RKRAVAKRLEAALSNGGLQLFYQSQIHLSNGRLAGAEALARWQDAQLGVISPTDFIPIAEERGLIGTLGEWVLHEACHQVRLWQERHYPPGKVAVNIATR
QFEDDDFVDRMLRIAREHRIAANRIELELTENGMMRDPERAVDIARALASAGFALSIDDFGTGYSSLSYLQRFPVNKLKIDISFIRHMLTDRNDYATVST
IIAMGKSMELETLAEGVEQAEQVDALLSLGCMLAQGYHFGHPLAANDFETWLSHASS---
>tr|T0B3G6|T0B3G6_9RHOO Uncharacterized protein OS=Thauera terpenica 58Eu GN=M622_00780 PE=4 SV=1
--------------------------------------------------------------------------------------------SIIVLSPE
LRIESCNRCCAELLGEDSHALLGRP---LAAVLHADGLEEIHAV----LHGAPLDNQIFTLVHDDCRHARITLKRVCLGD----LGRALLVLDRINEEES
AEALLRQ--------AQAAARIGSDPEALEWSAETYRLFGVP--------------PGTR-MTYPDFFEDALRGQAYQVEHR-VELEGEIRWLEERAELR
RDADGSVLWVVGTVQDISERKRAERHIEKLAFYDTLTALPNRTHFQDQLKRRLARARSKGHALALLFIDLDRFKDINDTQGHLAGDKVLAEIADRFRSSL
RQGELLARLGGDEFVVIAD-EVDQGANAIALRLLGTLQTPFSVRGASFQLRASIGIAVYPDDAHSVQNLLKSADIAMYRAKGSGGGHC-LYSAEMGEQLS
HKLDVVQRFSQALRNNRLQLHYQPKLNLSDSRLTGVEALLRWHDPQWGWVPPTEFLPIIEERGMMTELGEWVLSEACRQLQTWKEAGLAPPRIAINVAAP
QIDEKDFAARTLAIIEEAGQSPTRFELELTESSMMRDPQCAMEVTQALVDAGFTFAIDDFGTGYSSLAYLQRFPVHTLKIDRSFVSGLLADGSNEGIVRT
IIAMAQSLGLTSLAEGVEDEQQARCLAALGCVEAQGYHFGRPMPGDELGRWLASPRQD--
>tr|N6X8X3|N6X8X3_9RHOO Diguanylate cyclase/phosphodiesterase OS=Thauera sp. 63 GN=C664_16450 PE=4 SV=1
--------------------------------------------------------------------------------------------GILVLSPE
LRIESCNRRFLDLLGEDSAVPLNRP---LAEVLRADDLDAIRAV----LRGGTVRDRIFSLVRRRTQSARITLKRVCLGD----GDRALMVIEEISHEEW
LEALLRQ--------AQAVARIGSDPEALEWSEETYRLFGIP--------------AGTR-VTYADFWEAALGGRPYVVEHR-IEIDGETRWLEERAEFC
RDAEGQLHWAIGTVQDITERKHTDGRIERLAYYDTLTELPNRSYFGENLKKKLARARAQGHPLALLFIDVDRFKDINDTQGHQAGDRVLAEVARRFRDTM
RQDELLARLGGDEFVVIAE-DTDQGAETIALRLLAAMRKPVGVRSTDFQLGASIGIAVYPDDATSAQNLIKHADIAMYRAKAGGGGHC-FYNPDMGERLR
RDLELAQRFGQALGNNQLQLHYQPKVLIGDGALAGAEALLRWQDPEWGWVSPADFLPIIEERGMTVRLGEWVLAEACRQLCAWRDAGLPPPRVAINVSAR
QIDEKDFAARALAIIDAAGLTPSHFEIELTESSMMRDPHCAMEVTQALVDAGFAFAIDDFGTGYSSLSYLKRFPVHTLKIDRSFVRDMLENGNDHGIVRT
IIAMAQNLGLTPLAEGVEDARQAECLHALGCVEAQGFHFGHPLPAVDFATWLRPPCLA--
>tr|C6HTT7|C6HTT7_9BACT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Leptospirillum ferrodiazotrophum GN=UBAL3_44810003 PE=4 SV=1
--------------------------------------------------------------------------------------------GILVLSRS
LTVLSANRAFLKQFGLSVDAIFGRP---LEQVLQASGLKEILEV----IGTGDRHDLLLSIAGEETQRMRITLAGMRLAEEEEEEAMVLVIVEDLTEEER
LERRFRE--------LAETAYSGIAMRIVYFNSAAEKMFGCNT-----------HVLERP-------FPDPLKDGESRIWDS-VGQRFDTQFMEISSSVF
SEPSGS-FV-TLVLRDLTERKTFENQLLYLANYDALTGLPNRIHLIERLKQAIPLAERNGQHLALLFLDLDRFKGVNDSLGHASGDLLLVEVSKRLSNCV
RKGDTVARFGGDEFVFLLEGLEEEDAKPIAEKILGALNAPFEIDNVQVFMNGSIGISTWPHDGESSDLLLRRADAAMYRAKELGNSYA-FYNPEIGALPE
RRFSMERELRRALERNEFELFFQPQIDLATGNCVGAEALIRWRHPEKGLILPDQFIPVAESTGLIVPMGAWVIRSACPHLKSWREAGMAPLRLTVNVSVK
QFERGGLIQTLESSMRESGVDSRLLEIEVTESVLMQHPMAS-DTLRELSRMGILISIDDFGTGYSSLSYLKKLPVYKLKIDRSFVTTLPVDPDMLAITTA
IVTMGSALRLKTIAEGVESREQLDILRRLGCDEIQGYYYSRPLPNDTFMTWVREKSTP--
>tr|A0A0E0SZ13|A0A0E0SZ13_DESVR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio vulgaris (strain RCH1) GN=Deval_0385 PE=4 SV=1
--------------------------------------------------------------------LRVANEALHRSSTRFRALFDYAPDGLLLQRDD
GTLLDCNRMAEATLGLSRHELLALKACRGHALPVPESEDTPLRTRTELLRGGVAFPVSVRSLDIEGE------------------RTLLVALRDISSRIH
TEHRLNLFELVFRNALEGILITDASGAILAVNPAFTTITGWNERDAVGRNPRILKSNRHDRGFYERLWHSLHERGAWEGEIWNRRINGENYPEWLSISAI
RDESGATTNYVALFHDISDLKAKEAQIRYQGMHDALTGLPNRALLLERLAGELKEGQGTGRLCGLLYIDIDNFKTINDSLGHEAGDKFIAEVAEHLTLLI
RPEDTLSRLGGDEYVILVANPGEREVVLVAERILHHFSQPIALLDRELHVGLSIGIAIHPADGKGPDELLTNADLAMYRAKAQGKNTYERFSPHLHDRIR
SRMELEGRLRHALRHGEIVPHFQPRVDLATGRIVGAEALARWTLPDGTRISPGEFIPVAEDLGLIFDLGEHMLRSSLAFTRALMDEGLPDITMAVNLSLV
QCRHADLVGRVLAALRDTGVPPERLELEITESAIMSDVTRTLRRLDRLAALGITLAVDDFGTGYSSLYHLKHMPLHTLKIDQSFVRDLPHVAGSRTIALT
MLAMARNLDLDVIAEGVETGAQMHFLRDHGCRVVQGFLFSPAVPGDRLFDLLRR------
>tr|U1KUJ4|U1KUJ4_9GAMM PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudoalteromonas citrea NCIMB 1889 GN=PCIT_00563 PE=4 SV=1
---------------------------------------------------------------------KLAHNKFTSANETIQRMYDYTPVAMLSIDNK
GVINAVSEQWLSLLGYPREAVLGRR---AIDFLTPASRDYTNYVLPEFFKLGKVERIRYQMHHYDGHIIDVELTSVMEPESLRGGFNSLAVIKDVTTEIT
LTKRLAQERTTLMSIGDGVVATDVNGLTRFVNPIAESLLGVRAGEALNKPAEIHLIDRHDSTRLPCPIRQVLDSREMYTDAILVSKSGVQYSIQDKTTPI
VTSKGELQGVVMVFQDVTELVASNDRMAYLAQHDALTGLPNRTLALDRLYQACSKHSRVPQTFAVAFVDVDNFKHINDSFGHDCGDVVLQTLGKKLNTIL
RSSDTAARLGGDEFLLLLHGVTDQAVSQIYEKLNRAISEPIVVNKQSVSVSISIGVCVFPEDGLEPDTLLKRADEAMYQAKSHGRNRLSFYSQSAMQSSL
SHVQLQGLINENHKRSEDMFVMTPLIRAVDHSIQGIVDQGRWLPEHKGL---DVFVLA-RQQSLFSQINDLWFLGLNHVLSEVATHGV--RDIIVRINDE
QILSDEFYHGLKSSIKDLNVNPSKLVLSFQESVLCHGSKTVIDAVSRLKALGLRLDVSEFGVHSISLDFLNLLPLDSVTLGEGLTSQMETEQHNETLTYS
LVKLAKSLNLTCCAVTVSTSYQATLLEAMGCDHLLGNYFYKTVNIEQLNVLI--------
>tr|F2K112|F2K112_MARM1 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC
---------------------------------------------------------------------NKTLSDLETSEASFRALYEKAPIAMHTINTA
GVMTYVSDRWLSMLSFKREEVIGKR---SIDFLTPSSREKKREYFPELISTGYLTDKEVQAIKKDGSIIDIDISAVVDPIKNNGAIHAIAALKDITEEVH
LREALAEEKITLHSIGDGVIATDKEGCITFLNPVAEQVLQLSKNDVIGTKFEVYLFDQRTGNIIDDLISRVLASESTQRFAAIKNHRGQICCIQDSISPI
KNNNGDIVGTVMVFQDVTENRNMSRQMEYLAHHDMLTKLPNRALLINKLLELCPHDDIPEESFALLFVDIDNLKSVNDQYGHKAGDELLIDTVNNIQQVM
RENDFLARIGGDEFILISPHYEESTFEPFCRKLIKSVCRPMTIEGHDIQTSVSVGVSFYPDNGCDADTLLSHADAAMYHVKAKNKNDYRFYTPEFDKETI
WLAEIEEKMRQGLPRKEFVLYFQPIIDSSSHTVTYFEALCRWHNDDAI-DIPDIFIPIAEQSGLIGSLTTQLLHQACSFIKELDES--N-IRISFNISAT
HLQSQDFMSEIKAVFDKENVVPSCFIFEITETVLMQNWKRNVSLLNDLKLLGVEIAVDDFGTGYSSLGYLKRFPVDILKIDREFIRDLHHDAKNRIFVSA
IVSMASALSLRIVAEGVENKEQASILAEMNCFLQQGYYYSKPLPILKVLRHL--------
>tr|A2SDI4|A2SDI4_METPP Signal transduction protein OS=Methylibium petroleiphilum (strain PM1) GN=Mpe_A0661 PE=4 SV=1
---------------------------------------------------------------------RQHVHEIEDREAQFRTLYERTPVMMHSVDVE
RRLVAVNDAWLARLGYERSEVLGRR---STEFLTAESRERERSIIPRFMREGELRDMDYQMVTRSGEVLDVQISAIWETDAHGQPLRTLAVLKDVTEQKR
LALELAAEKVTLHSIGDGVISTDEAGRITYLNPVAEQMVGCLLAQARGLPFAVQLFDQESGAPLPSPVEQCLQDREVYGSAALRHRSGRDYGVQISAAPI
AGRDGRVLGAVMVFQDVTEARGLAQKMSYLAHHDGLTGLPNRVLFQDRVHQACQSGRRHGRRFAVIFMDLDHFKHVNDSLGHAVGDELLKAVAQRLTGAL
RASDTICRLGGDEFVVLLSDLDDEVVAEVAKKILRQVAQPCVLGGTEVNVGASLGIALFPGDGEDPDTLMKRADAAMYRSKREGRNRYHFFSKAVDDAAS
ARLQLEADMRRALAAGQFIVHYQPVVHGRTRDAVAVEALLRWDRAGQG-LQPAVFIPVAEESGLIVPMGHWVLRQACEQLRAWSGTALGGISVAVNVSPV
QLAQADFVDTVADVLHATGVDGSRLEFEITESTLMQDPEATLEMLRRLKGLGVRIAIDDFGTGYSSLGHLKRFPVDTLKIDHTFVRDLEADADDRELVRA
ILAMARSLRLHVVAEGVETEAQAAILAAMECPAFQGYLFARPAGAAVTA-----------
>tr|A0A0C5VU85|A0A0C5VU85_9GAMM Uncharacterized protein OS=Gynuella sunshinyii YC6258 GN=YC6258_05693 PE=4 SV=1
---------------------------------------------------------------------TLIMNRLEEQMISTRDALLNMPALLCTIDAG
GHAVLASKRFLRIMELDTTELIGYP---FSKIVMPESMATNEEVLDALQKGDLVENVMIKVRSRYGREIYLSVSASFESNGDPNQKVYHLHIQNISEEVR
LSEKLMEENITLRSIGDGVVATDNNGNITFINAVAETLLHTSTDVATGKHFNIHLYDEQSGKRLDCPVDRVMQEKTVQGFAVLKNINGDTFGIQDSISPI
TNQKGEVVGTIMVFQDVTETRKISQKMSYLAQHDMLTDLPNRILLMDRINLAIARTKRSAYSFCVVFMDLDNFKTINDTQGHEAGDQLLQIIASRLRKHV
RGEDTISRIGGDEFVFVFEGISDSAVTRICDKVIDDVRQPMIINHKSISVSCSMGAALCPTDGEDSETLMRRADAAMYRAKHTGRNRVCFYSHQIEKVLS
RQVALEDDLRAAFKQEEFFLYYQPIVDSDTGEVYATEALCRWKNPKTGEMVPATFIPVLENIGLISDVGKYILEAACKQMTEWEVQGKE-LHMSINISAR
QVADNSFIDSVATTLSNHNLSGTRFIFEITESLLLTNTDQCISVLRKLRSMGIRIAIDDFGCGYSSLSYLKKFPFDVLKIDKQFVQELDSSQQDVIFVKA
ILDMAKALSLKTVAEGVENEKQARILQNLGCDTLQGFYFSAAESGQQIRARM--------
>tr|U1JMS9|U1JMS9_9GAMM Signal transduction protein OS=Pseudoalteromonas citrea NCIMB 1889 GN=PCIT_12479 PE=4 SV=1
---------------------------------------------------------------------KRSQVQMQQVDNNYKHTFELSPIMLTTLDEQ
GRILHISDGLTKCLGYQREQLLNKP---ITNYMTEHSASLHQMGLSGDTR---FTIESIVLLTKNLRQTCLLQADVF--NKSKAGDHTLCFFQDISERQK
LSEALSKEKVTLSSIGDGVICTDVESNITYMNPVAEAILARLTNEVIGLPFQMPLFNEDTLQPIENLTDYCMGNHQTLGLTCVKNHLGLTFAIQDSISPI
YGKNGQIMGSVMVFQDVTESRMMSRKMNHLAHHDALTGLPNRLLLQDRLIQACKRARRCKHQFALVFIDLDKFKKINDSLGHDYGDLLLKQVAERLAGCV
RACDTVSRMGGDEFVLLLDAIEDRHVRKVIKKVLQSTTGEYELKGIQLEVSLSAGIAIYPDDGDNAETLMKHADTAMYRAKKVAKTDFQFYSARLDHEAE
LRVEIESAIHKGIEHDEFLPYYQPIVNAQSFELEKLEMLARWQQKDQ--LVPAHFISIAEDANSITRLSQQLLNKALPQFARWLLVKPD-LIMSINISVL
QLSEANFVNSFIELVGDFGIPTINIEIEVTESSLVSNIESMQKTLLLLQEMGFAIAIDDFGTGFSSLNYLKHLAFDTIKVDQSFVDDISGGKSNGDLAVV
IVNMAQSLNVNCVAEGVENAMQAKVLAACGCQQLQGYFFSQPIDAQAVTLLI--------
>tr|Q2BH14|Q2BH14_NEPCE Nitrogen fixation positive protein OS=Neptuniibacter caesariensis GN=MED92_12481 PE=4 SV=1
---------------------------------------------------------------------------------EVNDLIDRMPGTFYRRSMV
GDLLLITHGCEHITGYTTQDWLTGQVTFK-DIICPEFYSHYKKVVDESLRLARPYSVEYQIIKQDGMRLWVWEQGHGVFSADK-LETIEGYITDIDAQKS
KQQLLEEYKGAVD-RSAIVSKTDARGVITYVNEQFCSVSGFQPAELIGATHSIVRHPDTPDIIFKELWSTIQSGKAWIGTLRNRSKSGDDYYVRSAISPI
TDANGEIVEFISVRFDVTELVKKDQT-IRRQTTDQLTGLANRQGLLETLSQNL--------SGYLIIININDFKLVNEYFGFEVGDQLLCDLAGLLRIAE
QYALKLFRLSGDEFAFFTNEATRLSFDRIC-DLIVEMVNNLKVLETEFALAVTAGA-----SSGACPELLLHADIALHSAKAQSVEIYDTYSPLKR-QID
NNITWLKRIREAIADDRIEVFAQPIVDASDVESVRYECLMRLRE-DETFCSPYLFLQAAKNGRLYGDLTRIMVEKACRFFSDR------CEAFSLNITAS
DILNPVTANHILESIKRYAVGDR-LIFELVESEAIENSELVIDFLDRVKVLGCQLAIDDFGTGYSNFEYLLKLDIDYIKIDGSLIRYIDRDENARIVAAT
VVDFARRLNVKTVAEYVHSADVEKAAREIGVDYLQGFLLGEPVPLSKL------------
>tr|A0A0A2TBC4|A0A0A2TBC4_9BACI Diguanylate cyclase OS=Pontibacillus yanchengensis Y32 GN=N782_10150 PE=4 SV=1
---------------------------------------------------------------------------------IVRDLFDHSQTMLWTYEWN
GD-SFISEGCEAVYGFPREAFESDPNLWL-KQVHPSDQAIADEFEIE-TLNGEQRTARYRIYHRNGSIKWIQNTGNPVYNRKGALEKIIGVTIDVTTEVE
TQKKLQSVQSAID-EAAIVTMTDASGTITYVNEKFVQISGYSSSEVIGKTHKLINSGFHSSSFFKEMWETIQSGNSWKGLIRNQGKEGCIFWMDATIVPI
LDSEGKPYEYVSIRYDITEQIESKHHIQYLAFHDQLTGLGNRHAMNTDLDN-TMSDRPYHKPLSLLFLDLDRFKTINDTLGHRFGDRVLNSISF-IKSFL
GDEAKLYRYGGDEFIVLVENGD-EQAVSMAQDMIAACSEPIQIDGCEVYTTPSIGISLFPDHAETSEQLLRMADTAMYAAKEHGRCGYRLYDTFLDEKTS
RTAYIERELRKALTEEDFELHYQPKVNLVTMEVVGYEALIRWRHETEGWISPGEFITIAEETDVIFGLGEWVLHQACRDMKQ-S-----QKQVAINISPR
QFEDPMFLSKIKGIFRQYEIEPSFFEFEITESVMKDKE-RTQSIVQDLKNMGIHISIDDFGTGYSNLALLSDLNIDVLKIDRSFIQQS-----NEELVET
VIRMGESMGCSIIAEGIETREQAMWLIKRGCSVGQGYWLGKPSPIAKN------------
>tr|U1JSG7|U1JSG7_9GAMM GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudoalteromonas citrea NCIMB 1889 GN=PCIT_03798 PE=4 SV=1
---------------------------------------------------------------------------------LLSDAFAHADEDRWMLEHS
LN------------------------LTS-K-----------------ELTENNRQLRTKLVD------------IDKY----------QRSLE--LSVT
RQ------KAILDASPEVVVEFNICGEITHINQSGCTFLGCDEGTALTLDLHSILSLLTAPDVFIEQIQAMFDSKELTGNF---ETIHGRYYEYYSVPEL
IHG--EYVGRVWCCRDITDLKAQKALLSKQANCDSLTGLANRFNIIATVNR--MLQSDVVKPFALVLIDLDDFKKINDSLGHLAGDDALKICAKRLERRV
QQPNRLARLGGDEFLVVLMLDSLAIREQL-EHILNAFIDPIKIEGNCYQLSLSVGVASYPAHGKEVSEILGKADIAMYQAKKQGKNQYKLFDSALEQRVQ
KAIYIEEKLQQAITLKQFELYFQPKINIASGQVTSLEALIRWPN-NGRMIFPDEFIPIAEDKGLIGKITECVLEMACDTLSQWHGLHLKDLSIAINISGK
DISVDNFYEKLERLLSRYKFNPSLLELELTESALISNLANVKATLKQLKKLGIKVAIDDFGTGYSSLAYLQALDIYYLKIDRQFVAALLSEPKAEAIVQS
IIDVGKNLGLCLIAEGVEQAAHLDKLHKMGCDQAQGYFICRPLPSSEL------------
>tr|H0Q395|H0Q395_9RHOO Uncharacterized protein OS=Azoarcus sp. KH32C GN=AZKH_1517 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------MELRNQRPDGEIWEAEVRCTSFRHHD--RTLIQLSLQDVTERKR
LLTQMSKAMVVFNASTQGIMTTDAAGVITSVNPAFTEITGYSAEEAIGKTPAILRSGKHEPAFYAQMWQALAATGRWESEIWNRRKNGEIYPQWQSISTV
RDERGQIVAYISLFNDITLRKQQDEAIWRQANFDALTGLANRSLLSDRLDHALAHARRTHTQVGVLFLDLDGFKWINDTLGHDIGDELLIEVAHRLTSCV
RDQDTVARLGGDEFTIVVQDLTHDDLHAIGEKVVSILREPFALGQIQHRISGSVGITVYPDDGDNVQTLFRNADIAMYKSKQAGKNRLQFYSRDMQTDAL
ARMQLEADLRIALDQHAFTLHYQPIVDADSGELIGAEALIRWDHPTRGAVSPLEFVPVAEDSGLIVAIGEWALREAARQSRRWRDLGYPSLRMAVNMSGV
QFREATLPGLVSAVLNEYGLDRDSLLVEITESVLMGGSETIETRMRAIKALGIGYALDDFGTGFSSLSYLKRFPVDIVKIDRSFIHDCPDDRNDAHLVEA
IINMAHSLDLRVTAEGVETEQQVSFLRDLGCDYLQGYFISKPADATEFETLLAHFLLPPD
>tr|A0A0E0T3A4|A0A0E0T3A4_DESVR Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio vulgaris (strain RCH1) GN=Deval_1871 PE=4 SV=1
-------------------------------------------------------------------EVKRSTGELRTALGELSAIVGGMGEGLLVVSAE
GLVLRSNEAFASLFCLEPF---GCPV-ALDALL-PLSQDDLRGVLEQSMRGEARHSGEYPFICGDGVRRWVGCTIEPVTI--GGKPCIVCLVQDVTARNE
AQQALRRAEGIFENAVEGIFQIAPDGMLLRGNPAMAEMFGYSDISLREVMAMFAEATSSDVFFH-----QLEMTGNVSGEFRARHREDRELWLRVNARRV
ADAHDATLFYEGFLTDITISHRSRQQLAHQAYHDPLTGLPNRLLFLDHLQLAMQRAARRDAMFTVLYLDLDRFKIINDSLGHGIGDALLREVACTLRRCV
RDVDTVARFGGDEFAILLEDTGNAGAVRIARRIRESLAQPVNIAGHEVFTTASIGIVLQTRDYLTPEDILRDADTAMYRAKEMGKSRFKVFNARMREDTL
RLMALETDLRFAVERGELSLRYHPIVDLEDGSLHGFESLLRWRRG-NEDVSPAEFIPVAEDAGLIADIGAFVIEDVCRQVAAWQDTACDCGIVHVNISGR
QLMRPGFAQMVDEILRRHGIAGSCLRFEVTESVLVRHGTLAVSVMHQLRELGIRLCLDDFGTGYSSLGYLRRLPVESLKIDRSFVWGMEKDEAGRALVRG
ILTLGLHLGLEVVAEGVETEEQAVLLRDMGCRYGQGFLYAKPLLSERVPPFVCLR-----
>tr|G2H3B9|G2H3B9_9DELT Sensory box protein OS=Desulfovibrio sp. A2 GN=DA2_0230 PE=4 SV=1
-------------------------------------------------------------------SVRQATAELGGALEQLSTIVAGMADGLLVTDPQ
GLVLRSNAALCEMFGLDADP-DGKPV-REDALLAFLADPMVSCTLPDGVGVGALRSGEVAAVRRDGTPCWVELSLVRRQV--MGTTYGICLVRDVTERRR
AQDALHRAEGIFEHALEGIFQSTPEGRFLSVNPAMARILGYDDEDLLVVIGVYVDPARRAEFVE-----RMEEHGQVTAEFRARRKGGEYVWLSVNARRV
PGADGATMYYEGFLEDVTLGHESRERLEHQAFHDPLTALPNRLLFHDRLQMALKRAARRNYTFAMLYLDLDRFKVINDSLGHDVGDALLKVVAEKLRECV
RDVDTVARFGGDEFGVLLEETPSGTAVRVARRIRAHLAEPVRIGPHEVFTTASIGIVLRTDQYSTPEELVRDADTAMYRAKEQGQSRFKVFNKRMREEAL
RLLTIETDLRRAVERQEMRLHYQPVVSLEDGGLHGVEALLRWTRTEGGDISPSEFVPVAEDTGLITSIGAFALEEVCAQLRRWSDAGLPPGVVHVNISGR
QFMQPGLPHAVETLLDRTGTDPRTLRFEVTESVLMRHGSQAITVMGQLRELGIRLCLDDFGTGYSSLGYLKRLPVDSIKIDRSFVAGLEHDRDGQAIVRS
ILSLGLHLGLEIVAEGVETPTQAEILASLGCRYAQGFLYAPPLAAGDLAGMLGAA-----
>tr|T2GDX7|T2GDX7_DESGI Putative sensory box protein OS=Desulfovibrio gigas DSM 1382 = ATCC 19364 GN=DGI_2653 PE=4 SV=1
-------------------------------------------------------------------KAQSATDELEDALAYLSAIINSMPNGLLVVDSR
GIITRFNKAFLGMLQLDERLVLGRPC-MEQ-ELGLLGRGA------ACSGAGNFAVKEIE-LAQPGRTLPVEVSTVCLRL--HEDRAILCVFRDITERKQ
NYEISRKAESIFEKAVEGIFQISTEGRYLAANPALARIFGYDSPEFMAVAPHFVDPESHREFLR-----RIEVFGQIKEQTRIKRVDGVLVWISSNGHKV
TDRTGETLYFEGSVEDMTVRREMENALRQQAFHDPLTGLPNRMLFQDHLQLALERSKRRDYLFAVLYMDLDRFKVINDSLGHETGDELLKAVARNLEVCV
RATDTVARFGGDEFAILLEEIDAREAVKIARRILEEVAQPLMLSGHEVFTTASMGIVLVTDGYERPDSILRDADTAMYKAKEQGKARFKVFNQKMHEQAL
RIMELESELRRAVERREIQVYYQPIVDLARQRIHGFEALSRWIHPRHGFIPPSEFIPLAEDTGLIAPLGAEVLRTACTTLLAWHQLFMDLPRMSVNISGK
QFLQPSLVGEIQAILAETGLDPQYLTLEITENVLMINAEGAGSMLAKLKRLGVCVSMDDFGTGYSSLSYLRQFPIDHIKIDRGFVSSCDEDAESFAIIKT
VLSLGAALGMEVVAEGVETVGQLGLLVDKGCQYGQGYLFSRPLPPEEMKAFIMQH-----
>tr|Q60BD0|Q60BD0_METCA Sensory box protein OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN=MCA0547 PE=4 SV=1
----------------------------------------------------------------------EAERALRQSEERLRLHVEHLPLAVIEWDLD
FIVSRWNPAAERIFGYGADRMIGRS---A-GILFPEDVLEQAEAIWREVSGGSGNRVVTANVTADGRTIRCEWYNTPLTTPDGTVIGVASLVDDITRREA
VEAELRLAATTFE-TDEAILIAGADGRILRVNAAFSRITGYRQEDVVGRNPRLFKSGLHGAEFYREVWRSLEQTGRWQGEIWNRRKNGEVYPERKTITAV
RSANGDITHYVAISSDISELKRTEEKIRQLAYYDSLTGLPNRSLIFERLTQQMKAARREGTYGALLFMDLDYFKTLNDSLGHHMGDRLLVQVAERLKNCL
EDEEAAARLGGDEFVVLLAPAKPGQAIVHARRVRELLSAPFQLDDYVHYISVSIGIALFPDGANTAEDVLKQADTAMYVAKNEGRDGVRFYESAMEAVVR
GRLELEKALRKALANDEFEVYYQPQM-LGDGRVVGAEALIRWFHPERGAISPDQFIPVCEQNGMILRVGAIVLRRACACLAEIRARGLALPKLSVNVSPR
QFMRSDLMTQLEQFCLENGVSPTDLCLELTEGVLLNHTELAVAQIGRLKNLGVSFSIDDFGTGYSSLAYLKHLPLDDLKIASAFVRDLEQDSSDAAIVET
IVSMARHLGLDVIAEGVETRTQVEILERYGCHRFQGNYFARPLPKDDFIRFV--------
>tr|H6LIJ1|H6LIJ1_ACEWD Putative signal transduction protein OS=Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655) GN=Awo_c178
-------------------------------------IDLVG-TIQD---------------MTE---IKELENEIIFIKKNLERAQRLAKIGSWEMNVL
TNQNFMSDEARRIFGVATDEFKGTF-EDFMSMVHPDDKYIIDESFKNEFLEE-PFNIEFRVIRKDGSIRDVTQIIEFNHDKNGRLYRVYGTIQDITEKKE
YEKSIQRIQMLIQESGVVFEIITADGVIKYISDTSKKVINYDAEGMIGKSFYYYQPD--EIPYLKELVQQAIEESTPTGIITFKGKTDKSIYLEVHIQNF
L-NHPIIQGLILDFRDVTNRIIMQKKIEKLASYDETTALPKQNQFKKELTQKCIEASINNASLIVMMLDFEGYKDINDSLGYMVGQQLIIQIVMRLKGLL
GKNTLISRYSEDKFAIVIEHLLNEAYEERVQEVIDFFHRLFKIDIFEFDVNINIGISVYPLEIEEIEKLIQYANIALVWSKKEGKNRYKFYSSELNIQNY
KQFQLRHDLRMAIKKEQFLVYYQPMIRIKNNNILAVEALIRWNHPDWGIVSPEEFIFLAEETGAIVEMGKWVLRKVCSDHRYWIQKGFGPVYISVNFSGI
QFYERDFVENIKEILAEYEVDPQYLIVELTESLLIENAYKAVEDIQKLQAAGIKVALDDFGTGYSSLSYLKNFNIDIIKMDASFLKNILTDKTTTIIAKA
IINLTKELHIKLVSEGLENWEQLSFLRENNCFSGQGYLYSRPVPLEKIDSILEKG-----
>tr|A6TT69|A6TT69_ALKMQ Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Alkaliphilus metalliredigens (strain QYMF) GN=Amet_3249
-------------------------------------IGILG-TIQD---------------ITE---NKLLKTQLEKSYKNLAEAQRLAKMGSWEMDVI
RNKNTWSEEYYHIYGITNKEYDGSY-EAFLNFVHPEDRELIEDILAHPPQVQ-PFDMEFRIIRPDGSVRHIYQVVEMTFDLEGHLTYRRGIIQDITERKA
LVKKMQHIQVLIRDSSDVFEIVSPDGTIEYISPAVEKILGYQPKEMEGRNLMFAWEI--EKPKLEKMFKVALSNKNIKREISAETKLGKRIYVELTMNNQ
L-EEPSIKGIVLNWRDVTERVEAQKKMNHIATHDQMTQLPNRLHFEKKIEYQCQEAKEKGTTFAVMMLDIDDFKYINDALGMGFGDQLITQAARRLKDFL
GETRCICRYSGDQFGILIYNLKDEAYKNIAMKIIDLFSSSFKIDPYEIYITMSVGVAIYPDDGQETQSLIKHGNIALFRAKEAGKNRYEMYSPKMDVKNY
KAFTLKNDLRRAIKNNEFKVYYQPQVNLQTSEIIGAEALIRWEHPTWGLVSPKEFISLAEETGFIITLGNWILRQVCETYQKWLKDGLPAIKVSVNYSGI
QFFQKDIVENIKNTIHEFQLDPHFLVMEITETVLMNQSQQVSADIQSLQELGIKVAIDDFGAGFSSLTYLNSFNVDILKIDRFFIKGIPLDETSNRIIEA
VINLAKDLRIRLVAEGVETWDQLSYLRKLNCTVGQGFLYSRPVPQEDFEKLLAKK-----
>tr|T0BEZ8|T0BEZ8_9BACL Uncharacterized protein OS=Alicyclobacillus acidoterrestris ATCC 49025 GN=N007_01790 PE=4 SV=1
-------------------------------------THVEG-TLRD---------------VTR---MVMQHN--LFVLKNQHVLENYETDPLVILDKH
LNVAKWNQASQALFGWS---------EKELLLHQPENKEAMYNLYQTALQHGGTICFDNDYIRRDGTTFTATVCLFSLHNELGEIIGVAEHYQPLIHSNM
TE----QSEALTRHSSDVFLTLTRDMRISYVSNAIENVLGHRAIDVAQTDFLLVHPN--DRQLCEEAIQNLSNQNKIKIELQIQNKDGIWRICDATFHNL
H-KGKRTDGYIVNFHDITENKQTQELMNYIADHDWLTDLPNRRAFEEQLSAMIGLAAKRNHPFAVLTMNLNKFKYINDTLGHSIGDKLIQTISQDIRTRI
PSECIVARIGADEFAILVPGAENEHVYHLADQLLHLFEREIRIDQYAVYVSAGIGISFYPIDGTDTETLMKHADIALHHAKDVGHSAMQVYSTNLTAGAY
KQFSLANDFRTALRNNDFVLHYQPRIDAVTGRIVAAEALIRWDHEDWGLVSPGEFIQIAEDNGLIVPLGDWVIETVCQQLQTWSNSIAKGIKVSVNVSAK
QFLVANFVDSVRNALKKYNVPPQQLEFEITETTIMPNEPSVVKAIEQLRTMGIAIFFDDFGTGYSSLSWLHRYELDGIKLDRSFVSHVPDHWAPTQIVSS
VIQLAHSLGLTVVAEGVETIQQLDFLKQAKCEQIQGFLFSKPVPAQQFEELLRTG-----
>tr|J9H9C0|J9H9C0_9BACL Diguanylate cyclase/phosphodiesterase with PAS/PAC and MHYT sensor(S) OS=Alicyclobacillus hesperidum URH17-3-68 GN=URH17368_280
-------------------------------------SGLEG-TVRD---------------VTT---LLDTPMTRLFLAHD-KLL--NQPQAAVALDHD
LGIVHINQWTEQLLGWS---------EDELLFQHVSMESATHELYQTIVKTGGTIWLDTIRLHKDGSLRKVSVALGPLYDENGLVKGLLAMYTPVSGVSD
SM----ACEPFIEHATDVFLLLDRQYQVIYANAAVQEVLGMEPSETRQLSAPLVHPA--DRKEFEVACQRVGDTEPLNMELRFQHRSGEYRHCLASLFTW
I-SPGAQSHVVIRFRDVTETQSVRQQIEFLERHDELTGLLNRKAFFHESTVWIS-QSDPSHPLTVMVLRVQQFDRIIENLGHAVGDFVIRLAAERIRVRL
PKDNICARIGDHEFAIMVRQQERQTMLALANDLLRAFEEPFASAGHTIYLAADIGMSFCPNDGDDIATLVQRAGVALHRANGASENSVQTYSTQLHTDTY
KQFVLANDLRDALANDAFLLYYQPRVDAQSGRIVAAEALIRWEHPVWGLVSPVEFIPIAEETGYIVDLGYWVIRTACQQLRAWQNKGYPPIKISVNVAVK
QFQAKDVVQTVLSILDEWGIPTSAIEFEITETSVMPNDPTVIDTIQTFRKAGIAIYFDDFGTGYSSLSWLNQFQLDGLKLDKSFIDHLPNAWAPSQIVKS
VIQLAHQLGLTVVAEGVENVDQLTFLQSERCDQVQGYLYERFADL---------------
>tr|W1SJI7|W1SJI7_9BACI PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Bacillus vireti LMG 21834 GN=BAVI_08136 PE=4 SV=1
-------------------------------------TIIYV-IISN---------------ITE---LKEKEREILLFENRLKSIEGIGEIGSFHYDIL
NDCTHCSKQAQVIFGKSVEDFSPTY-TQLLELIHPNDYPILSAAFKKTLKDNSNKTVECRIVMQDQSIRHVFVQLEAFLGENRQPVRVMGFIQDITEQKM
----------------------------------------------------------------------------------------------------
----------------------LIEQVQHLSFHDYLTNLPNRRMFDGKLQQLTDGYRGNNKKFAVMIFDIDHFKYINDTLGHPIGDDVLNGLSARLLALL
SPDDLLARIGGDEFGLLIANMASDSLKELADRIINCLKEPFYIKGYELFLTASIGISIYPDDGVTSHELLRNADIALFKAEELGRNNYKIISPSSSIESY
KLFSLGRDLLKALENNEMVLYFQPRVDASSGKIISAEALIRWEHPEWGLVSPAEFLMLAEENGLIIQIEDWVLNEVCQQLKTWKEAMLSTVPISINISAT
HFMKQNWLETVEETIRNAGIRPTDLEFEITENSFLNNEEIVNRTIISLKEMGIKISLDDFGKGYSSLSYLAQFPFDFIKIDKLFIQNMIESHHDLFIVKS
IIYLAKGLDIDVVAEGVETIEQLKLLKKEKCQQIQGYLFSRPVPVKEIEPLLQKK-----
>tr|A7BUT7|A7BUT7_9GAMM Diguanylate cyclase/phosphodiesterase OS=Beggiatoa sp. PS GN=BGP_0538 PE=4 SV=1
--------------------------------------------------------------------RERMTIDLEASRQRFQAIFNEAAIGIALLDLD
NKILDCNRALQSMLRYREVELNNKF---LKKLTHPSDIQKDQLMLDRMLAGKDTYRIGKRYICKNGAIVWTNQSSSIVRD--TNHPFIISMIEDITERKR
AEEARLEAEEIFENAIEGIFQSTPNGRYLSVNPAFVRMFGYESAEVYTEITDIGQQLYVDPQRRLNLVEKQSNIPDFEYQA-RHRDGKKIIWVNETVHVV
RDKQGKIQYYEGTIENVTERKLIEEKLRHDATHDQLTGLFNRAAFTTRLTEAISKLKQEKSPFAVLFVDLDRFKIVNDSLGHLVGDQLLTEIALRLELKI
SKNDMVARFGGDEFALLFENIQDDDLESRVDTLQQQLNQPYLIKNDIFNTTASIGIALSKHEYLTADEMLRDADTAMYEAKKQGRGKSIIFQPSMRTRVV
NSHKLEQDLRKGLEKGEFCVYYQPIISLENRHTVGLEALVRWIHPERGFVGPDQFIPLAEETGLIKELGLWVFETACTQLRRWQIQHHANLGMNINVSPI
QLKQPRLVREIQDIIEKSGIKGPTCRVEITESAMMQDPESALTIFKELKNLEILLYVDDFGTGYSSLDYLQNFLLT------------------------
------------------------------------------------------------
>tr|G8LWI5|G8LWI5_CLOCD PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Clostridium clariflavum (strain DSM 19732 / NBRC 1016
--------------------------------------------------------------------KVDMTKKLQNKIEQYKKLFDLSPLGVVIHKNG
E-ILYVNSTFIQMMKLSSENIIGRQ---VSELIHPDYRNKVK--FDI-----VLDFVEQKLILPDETIIEVEADSIEEKH--MGQSVVICVFKDITDRKK
TERMLIEAEGLL-STLVGVC--LCQDNFIYANSYLEKLLDYSKEELYNM-------SFFDIVYDVEQYEPKKMKSDVISQFRIVRRDKKIIFVEAH-AAA
TTYYGNP-TTIVTLLDISHIKKTEEKIKYIAYHDSLTGLPNRYMLNDYIDKVISESRANDSEMGVMLVDLDRFKIINDSLGHSFGDAVLKEAAQKLKSCV
GDNNLVFRYGGDEFVILLPNT-DSGCANIAKNITDAFRQPFCVNGKKTFSTTSIGISMFPEDGDSAETLIKNADVAMYVVKDVGRNNYQFYHENFNKELL
RKMELENDLRKALDNDEFVLYYQPQIDLRTGKIVGFEALIRWNHPEYGLVYPAEFIPLAEETGLIVPIGKWVIETACKQNKSWQNMDYGYIPVSVNVSAY
QILHSDLSAIIREALDRTKLDPKWLIVEITESIMQDIE-KTDAIINELKSFNVKVAIDDFGTGYSTIGLLKNLKFD------------------------
------------------------------------------------------------
>tr|K6DKA0|K6DKA0_BACAZ Sensory box/GGDEF family protein OS=Bacillus azotoformans LMG 9581 GN=BAZO_03161 PE=4 SV=1
--------------------------------------------------------------------VWHFFRNIKNSERKYRLLVDHSPMGIMTVQED
K-ITFINKSGYQTLGADSSEVVGRN---VHDFINPEIKASIK--KDELIEEKDIDL--EMVLIPLNTVLN---------------NNELIIFKDITEKIQ
SK---TEAEELINSSIVEVV--DKKGRIVYVNDKFCNISKYSAEEVIGKTHRILNSGYHTADFN--LWETINKGQVWEGQVKNKAKDGSYYWVQTIIVPF
INSKGEPYQFITIRNDITARKEAEKEIKLLATHDHLTHLTNRRKFEYELQQAIRK------SVAVLFIDLDRFKYVNDTLGHSIGDNLIKAVAKRLKGIV
EKDAIVSRQGGDEFTILVNYR-DNSIEIIAKEMIDRIKQPYMIEQKEILITCSIGISIYPEHGNDIETIMKNADVAMYWSKDKGKDGFSFYEPHMKEKSV
RIMQLELELRKAIDNNEFILYYQPKIDLKTNEISGCEALIRWNHPTMGMVSPAEFIPLAEETGLISQIGEWVLREACLQNRKWHEAGYNNFIMAVNMSAH
QFKQPTMIGMIERILHETNHEAKHLEIEVTESVSMLSEEVIMSQLYALKRLGVSIAIDDFGTGYSSLKYLDMLPAD------------------------
------------------------------------------------------------
>tr|A0A011QJN7|A0A011QJN7_9PROT Cyclic di-GMP phosphodiesterase Gmr OS=Candidatus Accumulibacter sp. BA-92 GN=gmr_15 PE=4 SV=1
-------------------------------------------------------------------------ADLLERENSYRTLVENLPVIISRYDDQ
YRHLFTNASFEHSLGLAPGSVLGKTLEVFSE-FPGLDAALLDQWEGAVYECNRAQQIEFGFPTPLGPRY-F--DGVLVPELPTGVTSVLGIFHEITERHT
AEAWARKLSLVVEQNPATIIITDTEGRIEYVNAKFVETTGYAKDEVIGQTPAILKSGRTAASTYVELWARLKAGGSWHGEFENKRRDGSLYHERALVAPV
EDSQGRTTNYVATFTDITERKAAQQRAEFLAHHDPLTGLPNRLLLRDRLEQALATARRSHGRVALMFLDLDRFKTINDSLGHPVGDKLLQAVVARLTTCV
RESDTISRQGGDEFVIVLRDARDESVSRLADKIQQRMGEPFRIDQHALSTSFSIGIALFPDDGQDFDSLTQKADTAMYHAKHAGRNAHRFFTEQMNVQAV
EHMHLETRLRQAIERAEFVLHYQPQTDLASGAITGVEALVRWQSPDQGLVAPARFIAIAEETGLIVPLGRWVLGEACRQASAWQAAGLPPFSVAVNLSGL
QFRRSDLLETVINALVLADLDSEWLELELTESILIQDAEITLETARRLKAIGVKLSVDDFGTGYSSLAYLKRFAVDKIKIARPFVRDLVSDADDAAIVRA
IVQMAHALKLRTIAEGVENAEVAEELRRSQCDEIQGYWIARPMPADALAAFV--------
>tr|A0A0C5VGU1|A0A0C5VGU1_9GAMM Uncharacterized protein OS=Gynuella sunshinyii YC6258 GN=YC6258_01758 PE=4 SV=1
---------------------------------------------------------------------------LEAREAELQSLVRAIPDLAWQKDRD
GRFRNCNQELENLFGISREGIIGRT---AADFYSPEQAR-IFD-EEDVISQGQPLHEHWITFTRTGHKGLFELSKNPVFDSRGNVIGLVGIGHDVTERRR
AEQELRIAATTFN-SQEAITITDAENHILRVNQAFCDISGYSCEEVIGKTPNILASGRHDDTFYEHMWQQLKQFGHWQGEIWNRRKNGEIYPEWLSINVV
KDSQGHITNYVGTFLDLTSNKQAEEEIERLAFYDLLTGLPNRRLFMDRLRQAQTNRARSNHINAVMLIDLDNFKVLNDSGSHDIGDHLLVQVAERLQNFI
FDGDTAARLGGDEFIVLLEELSDSQAKDVAEQIQQLLARPYTIADQIYHSTPSIGVTMMVSADEQAEDLVRQADIAMYQAKNAGRNTIRFFDPQMQSVLT
QRATLESELRAAIDNSEFQLHYQPQVDS-TGTIIGAEALIRWNHPVRGIIYPDQFIPLSEQTGLIEPLGQWALEQACRQLMRWSEDDRTQLILAVNVSAR
QFHQDNFVEQVRQAISHSGASINHLKLEMTETMILGDVSGAITKMKQLQSMGIGFSLDDFGTGYSSLSYLTQLPLEQVKIDRSFIHNLPHNENNATVVQT
IISLTRSLGLKVIAEGVETEAQRQFLNQHGCLHCQGYLFSRPVPIERFEQLLQL------
>tr|A0A091BE95|A0A091BE95_9GAMM Uncharacterized protein OS=Arenimonas metalli CF5-1 GN=N787_03525 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------GRLVGMDPADMIGRS---ICELF-PVNRTHYFEHYREL---F-------LQKRSVVDEFPIQSPTLKARQAVPWSRGVALSAEDITAEIE
RKQALESRQAFLEQIPGPAWIADDVANRRYVALGGDRVAASGPVSLD-ALFGALQGS-MYRLHNAE-LISTGQATRSL-ETGPLAEGGTAQYD--VYRFP
IDADHERL-AGGFALDVTDRRRAEERAEFLGSHDAATGLLNREGFVRRLAERLGA-PGARPLVA--RISLREAEALREVLGSRFVDRLVQAYAERMAGAL
VRHGVEVRDGPDQMLLALDEAG--VAAASLLAAWPALSREIALDDQRYSLNPRLGYVLADPAGTTAEDLLHACDLAHGEAVSRQTTAAIAYAPEMADRLQ
RRVEIQRELGNAVAGDELTLVLQPVFDEAAGAVAGVEALVRWHSPSLGAVSPGEFIPIAEESSAIVALGEWVLEHTCRELRQLDAGGGPPLYAAVNVAEA
QLARSDFAESIASLLHRHGLAPDRLELEITERTLMADTQVHQANLQALRELGVRLSVDDFGTGYSSLSYLLRFAVDKIKIDRSFVAGLGQQGSHDALVQA
LVALAASLRLHCVAEGVETEDQLARLRALGCAQFQGYLLARPMAPAALRDWLAS------
>tr|A4TWM9|A4TWM9_9PROT Signal transduction protein containing a membrane domain, an EAL and a GGDEF domain OS=Magnetospirillum gryphiswaldense GN=MGR_
----------------------------------------------------------------------------------------------------
----------EALFGWTASDLAGRA---MDDLL-AENGG--GN---GG---F-------LAIRKNGDQFPLELTTSEV---MEGHRLFVGIGRDITQRKA
TENALLESEAIAGNMPGMVFQRVLDGRFTYVSEGCRTFLGVEPEELLELFLQCMTAD-EQKLF----LAALARSAETL-EPAVFGAGRRRRWRG-QSRPN
RRPNGSVV-WDGVMLDVTERKTAEQRLSFLAYYDPLTRLPNRTAFLERFAGARENAARSHQLLAVLSLGIDRFGIINATMGHSVGDQVLTASADIVQSGL
SRNDIMARASGDRFLVLLSGHTSRELTEMVERIHGLAQSAVHVAGDEFEVSTSVGVALFPRDGEDAETLIKNAEAALQRAKSQGPATLQFFTKEMSSRAA
KTLSLQNKLRRGLEHGEFVPYYQPQVDLVTGAIVGMEALVRWNNPELGMVSPGEFIPVAEESGLIDGICESMLAQCARQNKQWQDSGFRPIPVAVNVSGR
QFQYARLITALETSLGESGLDPRYLEIELTESSAMRDADSAIAVVQTLKDMGISCSIDDFGTGYSSLSVLKRFPITKLKIDRSFVMDVITDPNDAAIVDA
IVAMAKALKMKVVAEGVEHTQHLDFLRALGCDQMQGYLFSRPLPATEMGQMLAD------
>tr|A0A0C2UYS6|A0A0C2UYS6_MAGMG Contig_1, whole genome shotgun sequence OS=Magnetospirillum magnetotacticum MS-1 GN=CCC_01067 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------EALFGWTMAELAGRP---FNTLL-PQSLH--HDDSAEV---S-------AGLRKDGSTFPLELSTTEV---LEGQRLFIGIGRDITERKL
TEAALRESEAIAANVPGMVFQRELDGSFSYVSEGCRAILGLGPEQLMDLFLALIPED-ERQSF----YAGLGRSARTM-EPAVPGSDGRRRWRG-QSRPT
LRAGGNVV-WDGVMLDVTDSKLAEQRLSFLAYFDPLTRLPNRTAFLERFAAARETAARDQTMLAVVSVGLDRLGIINATMGHGIGDQVLMAAGDLLRAAL
SPNDVIARTSGDRFLVLITGLGSREAMDALDRLRGSAHATVAAAGQDFDVSAAMGAALYPRDGEDPETLIKNADAALQLAKAQGPASFQMFTKEISARAA
KTLSLQTRLRRAIEHGELTAHYQPQVDLAGGNVVGMEALVRWNSPDLGMVSPVDFIPVAEESGLIDGICEFMLWECTRQNKQWQTEGLSAIPVAVNVSGR
QFQYARLLSACERALVDNHLDSRWLEVELTESSAMRDADNAIVVVNQLKEMGIACSIDDFGTGYSSLSVLKRFPIAKLKIDRSFVLDVTTDPNDAAIVDA
IIAMAKALRLKVVAEGVEHQAHLDFLRNLGCDQIQGYFFSRPLPAEGMRALLAE------
>tr|H8FW91|H8FW91_PHAMO Predicted signal transduction protein containing a membrane domain OS=Phaeospirillum molischianum DSM 120 GN=PHAMO_400010 PE=4 
----------------------------------------------------------------------------------------------------
----------QRLFGRSNDSLIGQP---LAALL-APEHR--HPESADI---S-------SALNQDGTTFALELSTSEV---LDGQRLFVGIGRDVTRRRQ
TEAALRETEAIAANMPGIVFQRVLDGEFTYVSEGCRSVLGISPEDLLARFLQMLTED-ERLAF----MTGLGRSARAM-EPSVLGPDRRRRWRG-QSRPT
RRASGEVV-WDGVIIDVTDRKLAEQRLSFLAYHDPLTRLPNRTAFLERFETARDEARRQSSLLGIVSLGLDRLGVINATMGHDVGDQVLMGVADLIRASI
GPSDMMARVSGDHFLLLLTGYDNRILEDALDRLHAQAQTTVSVGGQDFDVSAATGVALFPRDGEDAETLIKNADAALQRAKGQGTASFQMFTKELSTRAT
KTLSMQNRLRRAVDNGELSAHYQPQVDLINGGIVGMEALVRWTSPELGPVSPGDFIPVAEESGLIDVICEFMLDTCTRQTRDWQLEGLPSVPVAVNVSGR
QFQYARLIGACERVLSDTGLESHWLELELTETSAMRDADNAIAVVQRLKEMGIGCAIDDFGTGYSSLSVLKRFPIQKLKIDRSFVMDVATDPNDAAIVDA
IIAMAKALKLTVVAEGVERQEDLDFLRKLGCDQIQGYIFSRPLPAEAMRDLLVR------
>tr|H6SKD1|H6SKD1_RHOPH Rhodospirillum photometricum DSM 122 draft genome sequence OS=Rhodospirillum photometricum DSM 122 GN=RSPPHO_01820 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------GSVFGTPAAELIGRS---VGILM-ADTEPASESLYVLT---G-------EGQRRDGSVFPLEMALSEV---TEGRRIFIAVIRDITQRKE
TENALIATQNIADNVPGLVFQRLLEGRFLYLSNGAREVLGFEPQELLELLLDAMAPD-DREVF----LEALKQSATRL-EPKVLSRTGEERWRG-WSRPY
RLPDGAVV-WEGVSLDVTDRKRAEGRLTFLAYYDPLTGLGNRSLFVERFERARLFAQNMGTSVAVLSLGLDRFSIINATIGHTMGDKVLIAVARRLQQGL
DAGAIVCRAGGDRFLVLLTGIGAADLHEAVENIQASFETPIEVGGQQFDLTVSIGAAVHPRDGQEAETLIMHADAALHRAKEDGGRGFLLFTEEMGTRAA
KLMTMQHKLRRALDRQEFVAFFQAQVDVASGEIIGCEALARWNSPDDGMVSPGVFIPVAEECGLIDAICLHILTDSCRWLAEWSKRGLPEIPVAVNISGR
QFHNSQLLTIVDQTLAETSVRPSLLELELTESSAMNDPENAINVVRMFRDRGVSCSIDDFGTGYSSLSVLKRFPIRKLKIDRSFIMDVTKDPNDAAIVQA
IVALAHALKLKVVAEGVETLEQLAFLRSIKCDAIQGYLFSRPLPGEAMADLLAR------
>tr|K9HDU5|K9HDU5_9PROT Putative signal transduction protein OS=Caenispirillum salinarum AK4 GN=C882_2145 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------SRTFGWDADEMVGRN---VGMLM-TEAERVYDARYLDT---G-------EGVHRNGTHFPIELALSEV---TEGRRLFIAVLRDITTRKA
TEQALHDTEAIADNINGMVFQRVVDGRYSYVNEGARRIAGLEPEDMMALFLDCLASE-DRAAF----RAALDRGGRDL-EPRLTSHTGETRWRS-WSRPR
RLEDGTTL-WDGVALDVTDRKRAEERLMFLAYYDPLTGLGNRTLFLERFHKCRVAARRDNTWIGFLSMGLDRFSIINATLGHSVGDQVLKAVADRLAAQC
AEADVLSRAGGDRFMMLLTGVQTGEVFAAVERIQRAFDAPLTVGDQEFDLTVSMGASLFPNDGDSAETLIMHADAALNRAKAQGPGSFQLFTEEMGQKAV
KTLAMQARLRRAIENQEFVAFFQPQVEVKTGQFIGMEALARWISPDRGLVPPGEFIGVAEEYGLIDAICEQVLDDAVRWTKHWHDAGLPKVPVAVNISGR
QFHNVRLMATVEGSLERHQLDARYLELELTESSAMTDPENAISVVANLAERGVACSIDDFGTGYSSLSVLKRFPIRKLKIDRSFVMDVTTDTNDAAIVCA
MIAMANALNLKVVAEGVETQEHIDFLHGVGCDHLQGFLIAKPLPAEEMEAMFRK------
>tr|Q2RNE1|Q2RNE1_RHORT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 
----------------------------------------------------------------------------------------------------
----------GTFFGYARGELIGRR---VEILM-AEADRRHTRHYRET---G-------DGRRRDGTTFALELALSEV---TEGRRIFIAVIRDITQRKE
TEGALAATRTIADNVPGLVFQRELEGRFLFVSNGVHEVLGITPEALLALFLGAMDPD-VRAAF----RETLRQSASRL-EPKLRGRDGEERWRG-WSRPS
RREDGSVV-WDGVTLDVTDRKRAEDKLTFLAYYDPLTGLGNRSLFIDRFDRARRFAESIQAWVAVLSIGLDRFGMVNATIGHTMGDKVLIAVTRRLQQSL
EAGSIVCRAGGDRFLVLLTGLTDADLREVVATIQDAFVPPIEVEGQQFDIGLTIGGALHPEDGREAETLIMHADAALHRAKG-GGGAFQMFTPEMGARAA
HLLTIQHKLRRGLERHEFVAYFQPQVDLRSGLITGCEALARWNSPEDGLVPPGKFIGVAEEYGLIDAICGQVLDDSCRWLSTWRARGLPQVPVAVNISGR
QFQNAQLVAMVDQALRQSGVDPRLLELELTESSAMSDPENAIAVVNLLRERGVSCAIDDFGTGYSSLSVLKRFPIGKLKIDRSFVMDVTTDPNDAAIVQA
IIAMAHALNLRVVAEGVETLDHLAFLREVHCDAVQGFLFARPLPGEDMALMLAG------
>tr|S6GPS6|S6GPS6_9GAMM Uncharacterized protein OS=Osedax symbiont Rs2 GN=OFPI_08850 PE=4 SV=1
----------------------------------------------------------------------------KLSEQRLHDSQEVAKLGSWEWIVE
EDTVWFSTSLEKILAIEKGSEHFGI-KEFFQQVHPADRKTLLQSLAPKLQVGAIVSTDFRV-SVEGDIKHVHLMADVKQQADGKL-RLIGTCQDISERKD
IESLLKKLSSAITASSSGVMITDVIGTIEYLNPKFTETTGYELEDLAGSASVILSRDCLPEGQYDEVWGDILSGKSWRGDLQNIRKDGSLFWSVVSISPI
NNEYSELTHFVIVCEDVSELKDAHAKMEQLALFDELTGLPNRRWLFRKLAELFRNDVM-KYPAVVMLLDLDNFKAINDTQGHPAGDKLLIEVANRLKLSI
PDEGFAARLGGDEFAILISPVKNEQIENLAKQVLNDIARPFIINGSEIKISTSIGLAWLPKDGNMPDTILKHADLAMYQAKEMGRNQYRQFTEQLHDQLQ
RHIRFSRELPEALANGDFYLCFQPKVDLAAKKIIGVETLIRWKHPELGNISPFDFISIAEDSGFIVPLGNWVFAEACRQMKKLREMGYADLTCAINISLR
QFSDPSLLGVIEKSVRDNGLKPQNLEVEITESLLMEDVDKAIMTLKKIQKLGISVAIDDFGTGYSSFSYLKNLPINTLKVDRCFIKDIPRSHEDMKITAA
IISMAHSLNLKVVAEGIEVESQSEILLEQKCDIGQGYLFGKPMRLAELKQQLDQEEFL--
>tr|S6GF89|S6GF89_9GAMM Uncharacterized protein OS=Osedax symbiont Rs2 GN=OFPI_44850 PE=4 SV=1
----------------------------------------------------------------------------KLGEQRLQESHNVANLGCWEWRPA
TDQVWLSESLRPILCLDKEAKCSGI-DDFSRQVHSADKKQLMTLLKSKLQVNAVISTDFRI-SNDGMIKHVHLMASVRRQKDGSL-RLIGTCQDISERKD
IEASLQKLSSAITSSGSGVMITDVIGTVEYINPKFTEATGFELSELEGSTSVMLSRDCLPEDKYDAMWRDILAGKGWRGDLENIRKDGSSYWSIVSISPI
NNEYGELTHFVIVSEDVSKLKDAHAKMEQLALYDELTGLPNRRLFFRELTRLFGEDVM-KSPAVVMLLDLDNFKTINDTQGHPAGDKLLIEVAARLQQDL
SEDGMAARLGGDEFAVLINPVKNKQVDRMAQRVLDTIAKPYIINDNEIHISTSIGLAWLPKDGSMPDTILKHADLAMYQAKEMGRNQYRQFTEQLHDQLQ
RYIRFSREMPEALANGDFSLSFQPKMDLLAQKVIGVEALIRWQHPELGPISPLDFISIAEDTGFIVPLGGWVFEEACRNLRQLRNLGFADISCAINISLR
QFRDPELLSMIEKAMLDNDIAPEHLEVEITESLLMEDVDKAIVTLIEIQRLGISVAIDDFGTGYSSFSYLKTLPINVLKVDRCFIKDIPQSKEDMKITSA
IISMAHSLNLKVVAEGIETDQQRQFLLEQNCDIGQGYLFGKPMPLTELAALLGREREP--
>tr|X0NMV7|X0NMV7_PHOLE Sensory box protein OS=Photobacterium leiognathi lrivu.4.1 GN=PLEI_0984 PE=4 SV=1
----------------------------------------------------------------------KNEQELRQQRNRYAAIIKNSEDGIIVLNNK
RVITAINDAAFTILNLHGN-ALHKP---LIDLFKSEQIKTLVNLLNTDLLP-NSEHLKTHIKLKFRRSKHLEVIATKQ--VNNVDDNILLHIADVTYWVE
REKRLQALSLAAEQSTESVVITDKNGFIQYANGAYLKQSNKTFKDLVGSHSSCFDDYFDNDKERETLFNKLMSGQSIQH-VIAKKKENDITYIDYTISPI
RGDDGKICNYIATSKDITDRITYENKLHRLAHYDSITQLPNRTLFSQDIGRSALEAAKHQAQIAVMIIDLELTKQLHESMSNEEIEKILLILSKRIKSNL
DSNDMLARIDTDEFGILIHAFHDQVINQLAKRLLQIISSPLSLDCQVFSVSANIGIALSSNSETDPKILQKYAHIALYRAKALAGSNYCYFTEAMEVENV
QRLLLESDLRRTIGTDSYEYFYQPKVSTITHRLCGVEALLRWKNCKGEYRSPADVIPILESSELIIEAGEYLIQQACKQLKQWQDKEYF-FDLAINISAR
QLLEADLVQSITDAISQSGCDPRYLELELTESVLMCDVQFALTQLQELRDLGIKIAIDDFGTGYSSLAYLSRFPINILKVDREFIKELPFNKDSITICRS
IIELAHNLNLTIVAEGVENQDQLEFLESLGVEELQGYHFDKPLPLTSFEDKY--------
>tr|A0A0D8R4S5|A0A0D8R4S5_PHOAN Histidine kinase OS=Photobacterium angustum GN=UA32_12980 PE=4 SV=1
----------------------------------------------------------------------KNEQLLRKQRKRYTAVIKNSEDGIVVLNKN
RVITAINDAAFKILNIHSR-ALQKP---LIGLFYSKQIQDLTTLLNTDQLP-NTEHLKTHIKLKYKRSKHLEVIATKQ--VDNIEDNILLHIADVTYWVN
REKKLQALSRAAEQSAESVIITDKNGFIQYVNTAYIKMSNKPLNQLIGSHSICINDYIDDKNEQDELISKLVSGQSIRH-VITKKKDNDIIYIDYTISPI
RGDDGNISNYIATSKDITDRVSYENRLHRLAHYDALTQLPNRTMFTQDIAHSMKEAIRHKAQIAIVLIDLELTKQLHESMSNEDIEKILLIVSKRIKSNL
RETDVLARIGSDEFGILIRSFHDQTITQVAERLLQNTNAPLSIDSQVLSISTNIGIALSSDAESDPKLIQKYAHIALYRAKGLSGSNYCYFTESMEAENI
QRLILESDLRKSVGSDQYEYFYQPKVNANTHTLCGVEALLRWKNNKGEYRSPIDVIPVLESSELIIDAGRYLINQACLQLKSWQDKGHF-FDVAINISAR
QLLEADLVETITQAINNTGCNPHFLELELTESVLMCDVNFALKQLKSLRELGIKIAIDDFGTGYSSLAYLSRFPINILKVDREFIKDLPSNKDSITICRS
IIELAHNLNLTIVAEGVETEDQLKFLESLGVEELQGYYFDKPLPLSDFENKY--------
>tr|A0A0B7J707|A0A0B7J707_PHOPO ANT-220, BDW_PPBDW_I_Contig_2, whole genome shotgun sequence OS=Photobacterium phosphoreum GN=PPBDW_I20917 PE=4 SV=1
----------------------------------------------------------------------NEMNRIESSRLRYYSLIENTDSGIIVIDKN
RIIIAINSTAQKIFEFKKD-PINKN---IMSYLSSVDIKSIVALLNSDSMP-YNNKEKTQLKIDTPNSKHLEIIVTKI--DENNNDNIILQITDVTSWIK
REQKLKGLSRAVEQSKEAVIITDKFGFIEYVNSSYEKSTGDSFNNIVGLNSTIFKRYINDKEKIDDIQSKLNQGKTIQR-IISQRNDDSIHYLDNTISPI
RDENGRISNYISTSKDITDRINYEHRLHRLAHYDQLTALPNRIMFINELNKSLIVSRKNQSKMSILIIEIDLFKQLHNYLDYENIEKILIIASKRIRSNL
RDINILARLNNDQFGVIIQCVQQKDITRLAKRLLNNISAPINFDGKLISITASIGISLQKVSTLTAEQVIKNTNIALSFSKNKTKNKYCYFSHEMGTKTA
HKLELESELRKSINTDRYEFYYQPKVLANSHSLTGVEALLRWRDKDGHYQAPVDIIPLLESSGLILEVGPFLIEKACHQLKLWQQQGLN-INMAINISAQ
QLLDSDLIGILNNAIKKTDCDPAYLELEITESVLMTDIELAYQNLIALKKIGVKIAIDDFGTGYSSLAYLSRFPINILKIDREFVKELPHNKDSITIIEA
IIDLAHNLGLAVVAEGVENIEQIAFLEAIGVEEFQGFYFNKPLTQCDFNRQY--------
>tr|L8JHH3|L8JHH3_9GAMM Uncharacterized protein OS=Photobacterium sp. AK15 GN=C942_00005 PE=4 SV=1
----------------------------------------------------------------------RHEQKLKQENLQYSTVLKHVPDGLLTIDRD
MTINTINKAAGRILNINDDSAPGKS---LLKLISGDKNRQIKELVEQHNSDINDKPIKVRIKLSQLKTRYIEFIATET--HYSNRSEILLNFRDVTYWIE
REEKLKSMSRALEQSNDSIIITNNQGIVEYVNQAFEKFNGIKSRDILGAQSALLKETLDNDKEVRAVQDELKEGKTINR-VIARRQDDSIIYEERTISPI
RNNRGRISHYISTGKDITERILFENKLHKLAHYDLLTELPNRTLLLQYIESAMIQARKEFKSIALLTIDLDHFKQINDSFSHDIGDKVLTAIAQRIEHTL
REGDLLARLGGDEFAIVIKSDVSENIANLADRIINHIREPLCVENKELLITASMGISLFPDDSNNVDNLFKNADIALYRAKEKNRNQFCFFTRQMGLDNI
KRIQLESELRKSIGTDRYELYYQPKINAATRKICGVEALLRWKDEKGQIRSPVEFIPVLENSGLIIEVGEYLIHQACHQLQQWHQKGFN-IRFALNISAR
QLLNSNLVRTVQSALSESGCDPHSLELEITESVIMCDVTTALDKLVNLEKLGVKISIDDFGTGYSSLAYLSRFPIHILKIDREFIKDLPENKDNISITRS
IVELAHNLKMQVVAEGVETKAQQEFLDTLGVEEFQGFYFGSPMPLSEFERLY--------
>tr|Q6LQD7|Q6LQD7_PHOPR Photobacterium profundum SS9; segment 7/12 OS=Photobacterium profundum GN=PBPRA2087 PE=4 SV=1
----------------------------------------------------------------------IHEKKLKQEIQRYASVLKNAPDGLMTLNNR
LEITALNHSAERVFNITDTAAIGKN---IYDIVHDKKAKNLNQLIYQQLAMANNTPIKASIQLPNHSIKYVALIASET--VFSSTSEILLHISDVTDWIE
RELKLKSLSHAVEQSDNTVLITDKNGIIEYVNHSFEAFTGITSAQAVGRDSTLMKGSNETTSEIKHIRQQLKAGRTINR-VITRKKDNTVCYEDETISPI
RNDTGKISHYISTGKDITERVLFESKLHKLAHYDLLTELPNRLLLLQHIEQAITNAEEMKTSVVVFNIDLDYFKKINDSLGHDVGDKVLITIAKRITRSL
RDEDVLARLGGDEFAILIQSDTSQSIATLAERIINNICASLSIEEKSLSITASMGIAVYPENSVDSDALLKNSDIALYHAKDQGRNRYCFFTPQMGIESV
QRLQLESDLRKSLGTDQYTFFYQPKVNAKTHKVCGIEALLRWKNEEGQIQSPLGIIPILENSGLIVNVGETLINQACEQLAIWQSNGLD-LHFALNISAR
QLLHSDIVDTVYKAVTMSGCNPHYLELEITESVVMADVKLAFDKLIKLEALGVKIAIDDFGTGYSSLAYLSRFPIHILKVDREFVQDLPMNKDSVTITRS
IIELAHNLGMLVVAEGVENEGQIKFLTGIGVEEFQGYYFGKPMPIDEFELKF--------
>tr|A0A0C5WBL1|A0A0C5WBL1_9GAMM Uncharacterized protein OS=Photobacterium gaetbulicola Gung47 GN=H744_2c2353 PE=4 SV=1
----------------------------------------------------------------------NVQRKMTLKVLQYATVLRHVPDGLMTLDQE
MKIVTANNAARQILSLGSKDIIGCT---LTKLLPGTQFRRMEAIIEQHQLREKQPTIKIRLQFSNLKTKHIEIIATET--AYSSSHEILLNLRDVTYWIE
REEKLKCMSRALEQSNDSIIITDRRGVVEYVNRSFEEHNGIKSKDIIGKQSELLRNTLNSTSDVKHVQKQLKQGHVIER-VIAHKQDEHIIYEEKTIAPI
RNNRGKISHYISTGKDITERVLFENRLHRLVHYDLLTELPNRTLLQQQLGAAVKCNKHHGENIALLSLDLDYFKQINDSLGHAVGDKVIQTTARRIQRLL
RETDFLARLGGDEFAILLAQNANQNVTNIATRILKHISAPLVVEGKELFLTASIGISFFPDDSEIAENISKYADIALYRAKEQGRNQFCFYTQEMGVHSV
QQIQLESELRRTVGTDRYEFFYQPKVHAHDHKISGVEALLRWRNKHGEHESPLNIIPILERSGVIIEAGEHLIHKACQQLKEWQDKQIY-LNFALNISAQ
QLLGSNIVETIDKAIIQSGCDPKYLEIEITETVIMSDVNTALDKLIKLEALGVKIAIDDFGTGYSSLAYLSRFPIHILKIDREFIKELPWNKDNIAITRS
IVELAHNLNMRVVAEGVEHQSQRDFLSSIGVEEFQGFLFGRPQPVDEFEQHY--------
>tr|D0YY81|D0YY81_LISDA Putative uncharacterized protein OS=Photobacterium damselae subsp. damselae CIP 102761 GN=VDA_002244 PE=4 SV=1
----------------------------------------------------------------------LYEKKLRKERDRYSSVIRNTADGLILINRK
KQIKSLNYAACSIFNITTD-SVGQS---ILSITTDKTVTAILRLFNLSAEKPKHTIFKAKTILNTISIRHIELMVSKI--DSTNQDEFLFNIKDITYWVQ
RENKIRNLSQVIEQSDDGIVIISFDGIIEYVNKSFELAKNKRSYELVGTKAVLLEPYNIPDLELEQLHKKIQRGETIQY-IVDYFDNHNTIYEHKKISPI
KNNNGDITHYVSITRNITEQIIAEEKLKRLAHYDDKTSLPNRVHLTNKIANYIQSS---ETPAILLDIDLDNFKTVNETLGMECGDEILLVIAQRLQI-F
AQSGIIARVSGDEFVLFLTNLAVPDFQRFCQQIHEYISQPIQIQHKSLSINISIGIARYPQDATTTDSLIKYANIALYEAKDRGRNRDCYFDIEMAERST
KQLQLEMQLRESLGTERYELFYQPKVDTRTHKLVGAEALLRWRDQYGKLVSPTDVIPILELSGLIIPVGEQLITQACMTLKRWQEQGLQ-LHLALNLSAK
QLEDSDIVETFERSIILTGCDPSLLQVELTESILMTDVKLALDTLTRLQTLGIKIAIDDFGTGYSSLAYLHTFPIHILKVDRSFVKDLPFCADSITISKA
IVELAHSLNLQVVAEGVEDKHQAAFLNSINVDELQGFYFGKPMPIQDFETHF--------
>tr|U3HCE0|U3HCE0_PSEAC Uncharacterized protein OS=Pseudomonas alcaligenes OT 69 GN=L682_10530 PE=4 SV=1
--------------------------------------------------------------LTE---LKRAERRQRERDERLHLFFEAPLIGMALCSPE
HCWEEVNFKLCSILGRSREMLQGAD--WL-SITHPDDRG-AELALLHQVRSGDGYELDKRFLRPDESVIYTRINVRAVRDADGRLHALLALVEDVSARRE
AEARYR---ILVEHAPEAILVFDVERGITEANENAARLYGLPREELMGRMPTSFSPLLQADRPSRDVGHA-YAQAALAGEWLMRDVAGRVRPCEVRLVRL
PGGGA--PLIRLSITDISERQRYQREIERLAYSDELTGLPNRRLLLDRLQHAMAREVREGRYGSLLFIDLDHFKTVNDSLGHPVGDALLREVTARLASCL
RAEDTLARLGGDEFVVLLEALADEYAAEVGTKLLHSLHGSYRIGEHELSVSASIGIALHPFERQGAADVLKQADTAMYRAKQGGRNALHFFAPAMQAAID
QRLQLQSELRQAVARGQLFLEFQPQLSLADERVVGAEALLRWRNPTRGVVPPSQFIALAEETGLILELSDWVLDRASASLAQWLPQW-PELVLAINVSPR
DLRQGDFVARVSDCLQRHGVPAQRLELEITEGSLLEDVEQCIAAMQALKRLGVRFAIDDFGTGYSSLTYLKRLPLDRLKIDRSFVEGLELAGSDAALVDT
ILAIGHNLGLECVAEGIEARGQYQSLRALGCALGQGYHFSPPLDEAAFLDWLRQ------
>tr|A0A0D6STE3|A0A0D6STE3_9PSED Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudomonas sp. FeS53a GN=SZ55_2092 PE=4 
--------------------------------------------------------------LTE---QKRTERRQRERDEHLHLFFEAPLMGMALCSPE
QGWQEVNFKLCSILGRSREQLQGHD--WM-SITHPDDRP-QESELLVELRQGDGYELDKRFLRPDGSAVDTRVNVRGVRDAEGRLYALLILVEDVSARRE
AEDRYR---VLVEHAPEAILVFDLERGITDANENAARLYGLPREQLLGRMPDSFSPPYQADRSSQEVGRA-HARAALAGEWLMRDFAGRVRPCEVRLVRL
PGRDR--QLIRLSITDISERQRYQREIERLAYSDELTGLPNRRLLLDRLQHAMAREVRDGRFGALLFIDLDHFKTVNDSLGHPVGDALLREVTARLAGCL
RAEDTLARLGGDEFVVLLEALAPDHAAEVGAKLLQSLRGSYRVGEHELAVSASIGIALHPFDGQGAADVLKQADTAMYRAKQGGRNALHFFAPAMQAAID
QRLQLQSDLRQALARGQLFLEFQPQLELAGGQVVGAEALLRWRTPSRGVVSPAQFIPLAEETGLILELGNWVLDQACANLAQWLPHR-PALVLAINISPR
DLRQPDFVERVRDCLQRHGVPAHALELEITEGSLMEDVERCIAAMLELKQLGVRFAIDDFGTGYSSLIYLKRLPLDRLKIDRSFVEGLEQEGSDAALVET
ILAIGRNLGLECVAEGIEADAQYQSLRRLGCALGQGFHISEPLDGPAFLAWLQR------
>tr|S6BQ46|S6BQ46_PSERE Uncharacterized protein OS=Pseudomonas resinovorans NBRC 106553 GN=PCA10_54170 PE=4 SV=1
--------------------------------------------------------------LTG---QKRAERLQHERDKHLHLFFEAPLIGMALCTPD
QRWEEVNYKLCSILGRTREQLHGVD--WM-SMTMPEDRA-AEEALLQQVRKGDGYELDKRFLRGSGGTVHTRVNVRGVRDLDGQLYALLALVEDISARRE
AEARYR---TLVEHAPEAILVFDPQHGIVEANENAARLFGLSREQLNGHMPTSFSPPLQADRSSRDLGKA-YTRAALKGDWLMRDVNGRVRPCEVRLVRL
PGEGR--PLIRLSITDISERQRYQREIERLAYSDELTGLPNRRLLLDRLQHAMAREQREQRCGALLFIDLDHFKTVNDSLGHPVGDALLREVTSRLAGCL
RTEDTLARLGGDEFVVLLEALAEKLAAEVGEKLLGSLHGSYAIGEHELVVSASIGIALHPFAEQAASDVLKQADTAMYRAKQSGRNALHFFAPEMQAAID
QRLQLQSELRQAIDRGQLSLEFQPQLALADGRVLGAEALMRWRHPVRGEIPPSQFIPLAEETGLIIELSDWMLERACHCLASWQADL-PCLVLAINVSPR
ELRKAGFVERISSALKRYGVPAGRLELEITEGSLLEEIEQCISAMQALKALGVRFAIDDFGTGYSSLAYLKRLPLDRLKIDRSFVDGLAHDASDVALVET
IIAIGRNLGLECIAEGIECEEQLSMLRQRGCELGQGYHFSRPLDEESFRNWIRE------
>tr|L8MUC9|L8MUC9_PSEPS Diguanylate cyclase/phosphodiesterase OS=Pseudomonas pseudoalcaligenes KF707 GN=ppKF707_5185 PE=4 SV=1
--------------------------------------------------------------LTG---QKRAERLQRERDKHLHLFFEAPLIGMALCTPD
QRWEEVNYKLCGILGRSREQLRGVD--WM-SMTVEEDRA-AEEALLDEVRRGDGYELDKRFTRGSGGTVHARVNVRGVRDLDGQLYALLALVEDISARRE
AEARYR---TLVEHAPEAILVFDPQQGIVDANENAARLFGLPREQLLGQMPTSFSPPLQANSSSRELGHA-YTRAALKGDWLMRDVNGRVRPCEVRLVRL
PGEGR--ALIRLSITDISERQRYQREIERLAYSDELTGLPNRRLLLDRLQHAMVREQRESRFGALLFIDLDHFKTVNDSLGHPVGDALLREVTARLAGCL
RNEDTLARLGGDEFVVLLEALAEKLAAEVGDKLLQSLHGSYRIGEHDLAVSASIGIALHPFDGQAAADVLKQADTAMYRAKHSGRNALHFFAPEMQAAID
QRLQLQSELRQAIDRDQLSLEFQPQLALADGRVLGAEALLRWRHPTRGEVPPSQFIPLAEETGLILELSDWVLERACGCLASWQAEW-PWLVLAINVSPR
DLRKPGFAERISSVLQRHGVPPGRLELEITEGSLLEDVQQCIVAMQALKILGVRFALDDFGTGYSSLAYLKRLPLDRLKIDRSFVDGLDNDASDRALVET
ILAIGRNLGLECVAEGIENEEQATMLRQRGCELGQGYLFSRPLGEDAFGDWLRE------
>tr|U1ZXD2|U1ZXD2_9PSED Diguanylate cyclase OS=Pseudomonas sp. EGD-AK9 GN=N878_19395 PE=4 SV=1
--------------------------------------------------------------ISE---RKRAEQQLRERDERLRLFFEAPLIGMALTTPT
FGWEEVNHKLCAILGRSREELLRCT--WD-ELSHPDDLA-AEQQQLDAVLGGDGFELDKRFLRADGQQVHTRLSLRAVRNGQGRPGMFLLLVEDVSARRE
AEARYR---TLVEHAPEAIMLFTPKGGMVDFNENALRLFRYRREELLGKTVLEISPLRQADQLSAEIGKV-HLKRAIAGEWLHRDSAGRQLPCEVRLVRM
PGEQ---LLIRGSVTDISERQRYQREIERLAYSDELTGLPNRRLLLDRLQHAMDREAREGRLGALLFIDLDHFKTVNDSLGHLIGDALLREVTSRLAREL
RAEDTLARLGGDEFVVLLEALGDEHAAAVGDKLLRGLLGSCTIDGHELSISASIGIALHPLERQNAADVLKQADTAMYRAKHAGRNALHFFAPEMQAAID
QRLQLQSELRQAIAREQLHLVFQPQLALATGKVAGAEVLLRWRHPERGEIAPDQFIPLAEETGLIQDVGHWVLEQACAALTRWHRQW-PQLVLAVNLSPR
ELRQADCVARIQACLQRHGVAPASLELEITEGVLLEDVDQCIATMQRLKALGVRFAIDDFGTGYSSLTYLKRLPLDRLKIDRSFVADLDGEESGRLLVQT
ILVIARNLDLECVAEGIERAAQLELLREHGCSLGQGYLLSRPLAEAEFLAWLEA------
>tr|A0A0D0KJ99|A0A0D0KJ99_9PSED Strain MEJ086 contig_36, whole genome shotgun sequence OS=Pseudomonas fulva GN=RU08_14225 PE=4 SV=1
--------------------------------------------------------------ITT---RRRTEQQLRERDDRLRLFFEAPLIGMALITPT
FGWEEVNLKLCGILGRSREQLLACS--WE-TISLPEDLE-IEHLLLDDVLQGEGFERDRRFIRPDGAEVHTRLNLRAVRRGNGRVSMFLLLVEDISARFE
AEARYR---TIVEHAPEAILLYTRDGGMVDFNENALRMFACRREDLLSRRPFELSPLLQPNALSAQAGRV-YVEAALQGEWTHRDSSGRHFPCEVSLVRL
PGEP---ALIRCSISDISERQRYQREIERLAYSDELTGLPNRRLLLDRLQHAMDREMRDGSLGALLFIDLDHFKTVNDSLGHLVGDSLLREVTARLAGQL
RAEDTLARMGGDEFVVLLEALDAEQAALTAERLLKSLEGTCLIEGHELAVSASIGIALHPFGEQNAADVLKQADTAMYRAKQAGRNALHFFAPEMQAAID
QRLQLQGELRQAIVRNQLYLAFQPQLRLDDGQVIGAEVLVRWAHPERGEVMPGQFIPLAEETGLIKEIGNWVLEQACATLQRWLPEC-PQLVLAVNLSPR
ELRSRGCVARVSSCLQRHAVPAAALELEITEGVLLEDVEQCIANMQALKALGVRFSIDDFGTGYSSLTYLKRLPLDRLKIDRSFTQDLGVIGSNTLLVET
ILMIARNLDLECVAEGIETPEQLEHLKALGCEFGQGYLLGKPMAEADFRAWIER------
>tr|F4DZM3|F4DZM3_PSEMN Diguanylate cyclase/phosphodiesterase OS=Pseudomonas mendocina (strain NK-01) GN=MDS_0420 PE=4 SV=1
--------------------------------------------------------------ISE---RKRTESQLRERDERLRLFFEAPLIGMALTTQS
FGWEEVNQKLCSILGRSRDEVLASS--WQ-QLSHPDDLP-AEQASLEQVLLGDGFEMDKRFLRADGQVVFTRVSLRAVRGGSGRQAIFLLLVEDISARQE
AEARYR---TLVEHAPEAILLFNPDGGIVECNENALRLFRYRREELLGRSIQSISPLRQADRLSSRAGKT-FMRQAVAGEWNHRDSAGRQLPCEVRLVRM
PGEG---LLIRASVTDISERQRYQREIERLAYSDELTGLPNRRLLLDRLQHAMDRENREGSLGALLFIDLDHFKTVNDSLGHLVGDALLVEVTTRLAREL
RTEDTLARLGGDEFVVLLEALGSEHAAAVGEKLLRGLQGSCLIDGHELAISASIGIALHPMGLQRASDILKQADTAMYRAKHAGRNALHFFAPEMQAAID
QRLQLQGELRQAIARQQLQLVFQPQLTLSDDRVAGAEVLLRWMHPERGEIGPDQFIPLAEETGLIQDIGQWVLEQACATLARWQAQW-PQLVLAVNLSPR
ELRQAGCVERVEQCLRAHGVPAHALELEITEGVLLEDVERCIGNMQRLKAQGVRFAIDDFGTGYSSLTYLKRLPLDRLKIDRSFVADLDGAASGRMLVQT
ILMIARNLDLECVAEGIEQPSQLALLREQGCALGQGYLFGKPMDEAEFLAWLQA------
>tr|F6AJ35|F6AJ35_PSEF1 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Pseudomonas fulva (strain 12-X) GN=Psefu_4033 PE=4 SV=1
--------------------------------------------------------------VTA---RRRTEQQLRERDERLRLFFETPLIGMALITPT
YSWSEVNLKLCNILGMSREQLLESS--WA-QISCEEDLD-AEQPLMNDVMAGEGFERDRSFRRADGSLVPTRLNLRAVRRSDGGVSMFVLLVEDISARYE
AEARYR---TVVEHAPEAIMLYSDEGGMVDFNGNALRLFGYPREELLNRRPFELSPELQADRASSEAARH-YLEAALAGEWLHLDSRGRLFPCEVRLVRL
PGEP---VLIRCSVTDISERQRYQREIERLAYSDELTGLPNRRLMLDRLQHAMDREIRQGSLGALLFIDLDHFKTVNDSLGHLVGDNLLREVTERLEGQL
RTEDTLARMGGDEFVVLLEGLDAEQAAMVGERLLKSLEQPCVIDGHELSVSASIGIALHPFGEQNAADVLKQADTAMYRAKHAGRNALHFFAPEMQAAID
QRLQLQGELRQAIARDQLYLVFQPQLQLDDGQLIGAEVLVRWSHPEKGEILPGQFIPLAEETGLIQDIGHWVLERACATLQGWREEY-PGLVLAVNLSPR
ELRSQDCAERVRGCLERYGVPAAALELELTEGVLLEDVEQCIANMHALKALGVRFSIDDFGTGYSSLTYLKRLPLDRLKIDRSFTQDLGRNGSNVLLVET
ILMIARNLELECVAEGIETAEQLEHLKTLGCEFGQGYLLGRPMIEADFLARVAS------
>tr|A0A090AQU0|A0A090AQU0_9GAMM Diguanylate cyclase/phosphodiesterase OS=Thioploca ingrica GN=THII_3768 PE=4 SV=1
----------------------------------------------------------------------RTEKALARTLAEQKVILDNSPVGIAFLGEG
QRFVRVNRKLEEIFGYTELELQNQT---A-RLLYAENEE-LGTEVFPRLTKDDTYETEQLMRRQDGSWFWCRFLIKAVDPED-LSKGYIWNLEDVTNQKQ
AEENLRLAAKVFETTTEGILVTDTNTRVIMVNPAFTTITGYTLAEVVSKKPSFLHSGRHPLEFYKRMWRTLLKDGKWQGEIWNRRKNGEFYVEWAAIAAI
RDTHQQIVQYVSVFSDITERKRSEEMIWHQANYDALTNLPNRTLFVDCLARALLVAKRQQLKIAVMFIDLDRFKWVNDTLGHEAGDQLLQETAQRLRTCI
RDSDTIARLGGDEFTAFLTQIEDLAIKIIAERILDNLSRAYLIDNHEVFVSGSIGITLFPEDGQEVATLLKNADTAMYQAKESGRNAYRFFTPTMNAQIT
ERVQLEQALHQALDNNEFFLHYQPLFDLASEQIIGVEALLRWQRSHQDNIFPKQFLPIAEETGLINPIGQWTLMTALKQLQTWYTAELAPLQMAINFSTR
QLKNSSLVEMIVEILENIGLPASVLIVEMTESTLLENALTISPILQQLHDLGVTIAIDDFGEGCASLNYLKQFPIDILKLDQNFIHNLAIESYNKILIEA
IIALAHKLNIKVVGEVVETEEQLTFLRTHHCDWVQGKYFSNPLLPQEFEQFVKQ------
>tr|A0A081BXJ8|A0A081BXJ8_9BACT Uncharacterized protein OS=bacterium UASB270 GN=U27_04017 PE=4 SV=1
--------------------------------------------------------------------------GLTEAQRLGSWIWDIQQNTLT-----
-----CSDEAYQLFGLARHEFDVTT-ETFIAAVHPEDREF-VRQSVKQALSKQSPYNIERIVLPGAGERIVHERAEVIFDEAGNPVRMLGTIQDITERKQ
LEIELKKLSRIIEESINFVFITDAEGTIEYVNPTFERFTGYTRDEIIGQNPRILNSGEASRYFYEDLWKTITSGKTWSGDFKNRKKNGEFYWVKGLISPI
KNEKDQITHFLAIQEDISEKILAQQQARYLATYDRTTGLLNREKFIEALNEYI----SQGDSGILILTDIDGFKIINEVYGHNMADEFLTHLSKIVIKTG
KNQTILGRLGEDEIAAAILDISGKKGWEIAEHIRKTESVT--FTDEAIRTTLSAGIIEFPKHGLTTQEVLSRVDAAVYRAKEPGKNRCHLFLPEDRDIEN
IQFRQKERIIRALENDRLTPWFQPILNLHDQQIHHYESLARMYDETGNIILPGSFIRPAEEIGLINAIDRRIIQQVIDYQAKYKQQGQN-LSFTMNISGK
HVGDEQFLDFLSTTIEQSGADPQKLIFEITETAAVRDLEQAIKFITALKELGCRFALDDFGVGFTSFVYLKEMHVDFIKIDGFFIRRLHEHRYNQGIVRA
MTAVAKEMEIKTIAEFVECEETMRLLKPLGVDYAQGFLIGKPAPQPTFICN---------
>tr|G4SWK4|G4SWK4_META2 Uncharacterized protein OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) GN=MEALZ_3572 PE=4
--------------------------------------------------------------------------QLSKSEQL-RFFVDSSPDIIYMLNDR
GEFVFLNNAIANILGYDKSEIIGKS-LVYQADLDKAKYAF-NERRLRCKNSDQPKYVETSIVLSSKGVY-------KKKKENKEFVGTYGVIRDINDRKL
SENTLRKLNLAVENSPNLIYITDSKGTIEYANPKIFEISGYTAEEIIGKTPHIFSSGETPPHEYQELWSTISSGKIWRGILKNRKKTGQLYWAQQSIAPM
LDSDNRVTNYVAIQEDVTETLAQRDMITYQATHDPLTDLINRTEFDRRLKRIINTAKTKGSGHVLCYLDLDNFKIVNDTCSHTAGDELLRQISRQLSTLI
RNRDSLARLGGDEFAILMEHCTLEQAQATAERIRQHERYR--WDDKSFRIGVSIGMVTINAENGGFDELLKRADIACYIAKQDGRNRSHVFTESDQACID
YEAAWPEKIEQALSHNRFRLYRQRIVALKSIEGDHYEVLLRLQEDSGKIITPNAFLPAAERYQLAASIDRWVIQKVFNWMLEHPDRLSS-LTCSINLSTA
GLNDKGLLEFIIDRFKQTALPAEKFCFEITETATISNLTAATQFITSLKELGCRFSLDNFGSGLSSFAYLKNLPVDFLKIDGVFVRDIETDSVALAMVKS
INDIAHVMNKKTIAKFVENDSVMKILLDLGVDYVQGYGSDEPSLLK--------------
>tr|A0A0D6ACX5|A0A0D6ACX5_9CHRO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Geminocystis sp. NIES-3708 GN=GM3708_1019 PE=4 SV=1
--------------------------------------------------------------------------QLKNSEKKLKTIINNNLNGMVIVDQN
GKILFLNSEAEKLFNRKREKMLGEI-PL----------EF-DKIDIPHS-SWQLITVEIAIIWNDNNV-------------------FLISLTNITEQKK
IEEKLNILFQASEQSPASIIITDTDGNIEYVNPKFEAISGYKEEEIIGKNPRILKSGHTTSKDYENLWATLTKGKEWHGEFHNIKKNGELYWEKALISPI
FNSAGVITHYMAVKEDITEKKQQETLLQYQAKYDHLTNIPNRNYALEKVNYLLAQAKETQTNLGLMFIDLDHFKEVNDNLGHDFGDELLIQATERMKKAL
RNTDLLARLGGDEFFIAIPFVEKFSHLEVAEKIIKLLRQN--IFDHSVSISASIGVTFFPYDGDNLKQLIRNADLAMYQAKKQGKNQFKFYQSEMNKIEI
NKSNLEKNFHQAIERKEFQLVYQPVVELTTQLINSAEALIRWENKELGLIWPEKFIPILEKNGMIIPLENWILQSVVEDIKTWEE-IKD-I-ISVNLSEY
EFEDENIINRLTKFIPENHRQHNNIQIEVTEQMLLEKKSI-TTIFNDILKLNIDLCLDNFGIGFSSLTNLSKFTFSSIKIDSSLIHRIVEDDKIKLLVKS
IISVAKVLNIKTIAKNIETKEQLDILINLGCDYGQGYFFSEPLSTINFIQY---------
>tr|A0A0D6AUX3|A0A0D6AUX3_9CHRO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Geminocystis sp. NIES-3709 GN=GM3709_3458 PE=4 SV=1
--------------------------------------------------------------------------QLKKSEDRLRTIINNNLNGMLVVDQV
GKILFVNKEAEKLFDRNQKEMRGEL-PL----------EF-DKIEIPRS-NQQLMRVEMAIIWNDKSA-------------------YLISFIDVTERKK
MEEKLKILFQASEQSPASIIITDINGNIEYVNPKFEEVSGYKEEEILGKNPRILRSDHSSESDYKNLWQTITKGKEWQGEFHNKKKNGDLYWEKALISPI
FNSAGAITHFMAVKEDITEKKEQEILLQYQAKYDHLTNIPNRNYALEKINYLLTQAEENHTNLGLMFIDLDHFKEVNDNLGHDFGDELLIQATERMKKAL
RSSDLLARLGGDEFFMAIPAVEKITDLKIAKKIIDLLQKD--IFNHQVSISASIGITIFPHDGDNLKQLIRNADLAMYESKKNGRNQFQFYRIEMNKKEI
NKSHLEKNFLQAIEKQEFKIVYQPVVELNSQLIISAEALIRWENKEIGLIYPEKFIPILEKNGMIFALENWILKSVIQDIKKWEK-IKN-I-ISINLSEY
QFQDQDIIKSLMSFITENKSYNNSIEIEIKEEILLERKYLVSEILKDLSQSDINLCLDSFGVGCSSLKNLLKFTFKSLKIDPSLIHNLLKNEQTKQLVQS
IITLGKVLNIKIIANGIETKEEVDMLKELNCDYGQGYFFSQPLSPINFTQY---------
>tr|K9Z1S6|K9Z1S6_CYAAP Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cyanobacterium aponinum (
--------------------------------------------------------------------------QIQKAEKKLKTIINNHFHSMVVLDLD
GKVLFLNEEAEKLFNRTHEQMVGNV-PL----------EL-NKIEILRS-QSELITVEMAIIWNDDNA-------------------YLLSFIDISEKKK
MEQELKILYRASEQSPASIVITNVEGNIQYVNSKFETVSGYKKEEVIGKNPRVLKSGYTHETDYKNLWKTISNGKEWQGEFHNKRKNGELYWERALISPI
FNSVGAITHYIAVKEDITEEKQQQLLLKYQAKYDYLTKIPNRNYALEKVHKLLNQAEENKYNTGLMFIDLDHFKEVNDTLGHDFGDELLVEVTMRMKGEL
RSTDLLARLGGDEFFIVIPIVQSRHELQIANKIIQILKKY--IFQEKIFISASIGITIFPEDGQELKQLIRNADLAMYQSKKNGRDQFQFYQYDMNKVDI
GKSTLEKNFLNAISNDEFKIVYQPVIDIFTGKIVSAEALVRWENKDLGLIYPEKFIPFLEKNGLILVLEQWILETIINDLKFWER-YED-L-ISINLSEY
QFKNAKMVKNIKDLTGKKQLRQCNLCIEIKEEYLEENKKFIDSIFNDINSINIEFCLDNFGAGLTSISNLSKFPFKHLKIDQSLVQSLPRNSQNKNIIES
IIAVANILNIKVTAKGIESKAQLDSLRALGCHYGQGYFFSQPLSALNFITY---------
>tr|K9RM02|K9RM02_9CYAN Diguanylate cyclase (GGDEF) domain-containing protein OS=Rivularia sp. PCC 7116 GN=Riv7116_5756 PE=4 SV=1
--------------------------------------------------------------------------KLQLSERI-RDSLDVNFVIKTAAKEI
LQYLKCDRVLISRLDNLYSYIEQQ------------------------------------GISEIPQDNIAHK---YFIKDREEKALFLGAIDDIEASNL
DS---------LSLNNLQHFQVKA----ALTIPILFETDG------------------VLAPRTFFLWGFLSTTRQWKSE--------EIQFIQRLVNQL
A---------IGIQQGRLQLSTANKELKQLALCDSLTKVYNRRFFDEKLIQEWNRLRRIPSPLSIIMCDVDCFKSYNDTYGHHAGDKCLRMIADAIANTK
RPADCVARYGGGAFVIILPYTPARGALKVAEAIRNKKELP--HTSSSVSVTVSMGIASIPNSDDNPVLLVEAADHALYLAKAQGRNREQIYIHDIAREKS
KQLLWVKKLRKALDENKFCLYTQPIVPLNKDDKIHYEVLIRLIDDNGKVLFPEEFLEVANLYSMMPRIDLWVIDNLFNYLS-NASNWDN-I-FSINISGA
SLNDNQFLKYLYQKFLESSFPPHIFCFEITETIAINNLSQASKFIKSLKSLGCSFALDDFGKGMSSLTYLKNLPVDYLKIDGSFIREIHTEPVTKAMVQA
INYLADAIGVKTIAEFAENQEIVNILQELKIDYAQGYFFGKPSLIDSTAFP---------
>tr|L8M019|L8M019_9CYAN Diguanylate cyclase (GGDEF) domain-containing protein OS=Xenococcus sp. PCC 7305 GN=Xen7305DRAFT_00021920 PE=4 SV=1
--------------------------------------------------------------------------KLKISNQI-RKSLDLQSILNTATKEI
RSFFNCDLVWLAVINQKKISIKAY------------------------------------DINLNEKETINHD---CFYANPEENQFYLGIIEKSSRETF
SP---------TEILPN----TQS----RLIAPILIQIKDYYP-EQCDCASTQPAI-TSSITNNNNLWGWLKSAQKWQAE--------DITLLKALTNQL
A---------ISVQQGLLQL-------FDLALLDSLTQVYNRRYFDRQLDLEWRRLQRISAPLSLILCDVDCFKIYNDTYGHQQGDTCLQKVSQAISKVK
RPADVLARYGGEEFTIILPHTPQSGAIRVAETIRIAQELP--HINSLVDVTISLGVATVPNTEDAPQLLVEAADLALYQAKERGRNCLAVYPNSINKAKD
QKSRWAKRIRRALEKNLFSLYAQPIKLLLGKPTKYFEILLRLTDEKDQIIAPDVFLEIANDNFLMADVDLWVIDNLLKTLAENNHSWQN-Y-FSINLSGA
SLNNESFLDFLSHKLINYNLPSHLLCFEISETLIVDDFPKVARFIAKVRNIGCSFALDNFGRGMTSIGYLKKLPLDYLKIDGSFIKELPENKTSIVMMEA
IHYIADSIGVKTVAEFVENQTILDIVKDLKIDYAQGFHLGRPGLLMDVIL----------
>tr|L8M7J4|L8M7J4_9CYAN Diguanylate cyclase (GGDEF) domain-containing protein OS=Xenococcus sp. PCC 7305 GN=Xen7305DRAFT_00040450 PE=4 SV=1
--------------------------------------------------------------------------KIKLSENI-LQSLDLEVTLQKIVEDI
QKNLNCDRAIISSYTRNYHSFTVQI----------------------------------SIIPGIYGDFLSKNYAQDYDQYSVKSQQYQGLTEDINNCDL
ES---------SEQAYLKDLGIKS----QLVIPIFLNLELGTARNDRDPNSYTFQE-NLASDMSSNLWGWLNSSKTWQQP--------EINFLQHLVSQI
A---------IAIRQGLQQLQQQNQHLQELELYDPLTEVYNRRYLDQQLSLEWRRLKRNPSPISMIICDVDYFEAYKDIYGKQAGEKCLQQVAQVIAQAR
RPADFVSLYSTEKFAIILPHTPVQGAQKIVQAIQAKTNLP--HVKSSVGVTLSFGIVTIPNASESPSLMMKAAEQALYLAKSRGRNCYTTYNEEISQLKL
PELTWSKRLHSALEKNLFRLYAQSIEPLDNQQRQHFEILLRLQEQDDVIISPNDFLPVANRFSMMPQIDSWVIDNLFSQLA-NSQNYQK-F-FTINLSGA
SLNDDIFLDFLQAKIIEYHLDPKLFCFEITESVAINNIAKVSNFIKILKQLGCSFALDDFGTGMSSLSYLKELPVDYLKIDGSFIREINNDSITKSMVIA
INNLAQIIGLKTIAEFVEDQSILRTLKDLNVDYAQGFYLSKPCLLNNIIS----------
>tr|Q2BL49|Q2BL49_NEPCE Sensory box/GGDEF domain/EAL domain protein OS=Neptuniibacter caesariensis GN=MED92_04779 PE=4 SV=1
-------------------------------------------------------------FDKLGRQMESMLGDIREQENQLDAIFHNTPSAMFLKSTA
LTYLTANRRFSDLFVGEGIDIIGKT---DADIFPEEEAKLIRETDIQVIKTRQTQQTEFSLTTLDGP-RYFLSTKFPMINERGELYAIGGITTDISDKVK
AEREAEVTQQVFESAAEAILIYNPDGKVIT-NSSFNRITGYDDKKARLFALSILKDHP-------EIDATLSKTGRWQGESIRRKANGEPLPIWLSISAL
SSTKTEQSSYVAVFSDISELKEAEQKLEKLAHYDNLTSLPNRTLFYDRIESSLARAARNGKKTALLFVDIDRFKQVNDNHGHHTGDQLLVEAARRISAHI
RLGDTVARLGGDEFTVILSELDGDPVQDIARRIQKSLRDPFRLDDKEIFSSASIGIAMYPDDGRNAESLLKHADVAMYHVKERGRNDILFFDKAINEQAE
ARAQLEDNLKTAINTQQLFMVYQPRFNISGTEILSAEALIRWKHPEQGFISPGDFIPLAESCGLIVELGRWVLMQACQAAQEWENTGQN-TPVSVNLSAR
QLHDSSLLIDIENALNQTGLDPSLLELEITETMVIQDMETVISRLEAIRTIGVRLSVDDFGTGYSSLIYLKRLPVSTVKIDKSFIDDVPGSSGSENLVKA
VISMSHSLALNVVAEGVETEAQLSFLTENHCDEIQGYLLAKPDSAETLQRLMR-------
>tr|A0A081FTK9|A0A081FTK9_9ALTE Diguanylate cyclase OS=Marinobacterium sp. AK27 GN=ADIMK_4011 PE=4 SV=1
-------------------------------------------------------------FARVGRAVERMLLRIRERDKRLSSIIDNAPDLIFIKDLE
RRYLLASEKLASTLALQPDKIVGRR---DDELLKGEALARAQETDRHVIESGRPIQYESELGEGSAA-RIFLLSKFPILDDDGAVMSVGCIATDISTIKK
VQEELDLAHQVVAATNEAIIVLDADNQVISANRAFQSMCNADEFGGTLVLSRFLSTHP-------QISLHLHGHEAWQGECSLVRADGSSLPVLVSITQL
PGRDGQQ-RSALLFSDITNLKQAERKLEQLALYDALTGLPNRSQFHQRLMKQLLRA---PDTTAVLFIDIDNFKSINDSHGHALGDAFLRQVADRLRTCV
QAKDTVARLGGDEFTVIIADVSTSQAQAIATRILHVLREPFELGTNHCFSSASIGIAMGLDSGEDPEAMLNNADLAMYEAKMSGRNACYFFDPAINAKHQ
RRYQLEEGLRDALVRRQLFVEYQPRFDISASRVLAAEALVRWHHPVFGTVSPGEFIPIAESSNLIVEIGRFVLNEACREASILHRDGFN-ILLSVNLSPR
QLRDRDLIKDIEDTLYRFNLPPHLLELEITETYVMENIDQFIPVLSQIRALGVRLAVDDFGTGYSSLMYLKKLPVNTVKIDYSFIRDIPGDQDDENLVRA
IISMSHNLRLRVVAEGVETAEQLQFLREQRCDEIQGFLMGRPGSVEQLRRLSV-------
>tr|S6AAG9|S6AAG9_9PROT Uncharacterized protein OS=Sulfuricella denitrificans skB26 GN=SCD_n02029 PE=4 SV=1
----------------------------------------------------------------------RVEQSLAVVATRLRALVGATEDLVIEYDLM
GQILNIWTDNQTFLGLN-DSLAGKT---L-QQSLPDDMA---QAILLVLASGEIFEFTLSV---DEEDRFFMGRLQMLPSETGKAKNLVALIRDATELIQ
EEARRQ-SMETMNLLEEAIVDLSPEGWLLNFSSAWSKLCDIPVEKCLGTPLS-EYIYPDDRASLGELIEQLASASDVI-RFRLLPIQEDPIWVEARLLAH
CSRQGNVIALRGVLRDITSSHLQEQRITQLALHDALTQLPNRILLEDHLHQAIARAERNKTKVALGFIDLDHFKHINDTLGHNAGDAVLVTLSKRLQSVL
RGIDTLSRWGGDEFVVLLPDVNNEDFRSVAERLRDVARDSIDLDGVETKITLSIGFAVYPDDADGPETLMSVADHTMFHAKSVGRNNVQFFQDIHDKTDR
EHVQLQTRLSRAIQDGALQVFYQPVVDAETQRIVTFEALARWHDDQNGWVGPDVFIPLAEHLGIIQELGEQIFDHSLQRLKTWREVNKL-VQVSVNVSRL
QLFAPAFVQNLLKKVDDHGLKPQDVVLEITESVALLDLNYESKRLHELHAAGFPIAIDDFGTGYSALSQLHKMPVDILKIDTSFTSRMDTE-DGRRIVQA
IVQMADALNLKMVVEGVEKLETVHYLRGLGVSQMQGHYFSAAVPAGMCDSLLQN------
>tr|D0S9H5|D0S9H5_ACIJO Diguanylate cyclase (GGDEF) domain protein OS=Acinetobacter johnsonii SH046 GN=HMPREF0016_00145 PE=4 SV=1
---------------------------------------------------------------------------------KDHHLIDIIPQLFWIHNDL
C--KYINLPLRQYVGGMDLSADSFN--LV-EYIHPEDVPALDEFLHQPIIAELTFEKTCRIRNHQGQYHWFLVQGEMDR----STAGFQLSCTDIHQGMK
IYIESLALLDMLNASVDCIIVVEPDGTVTHMNKSACVMLLGSADVDFGMSWELLPPAVRKKA-KKALHDAGQGQSRFNG----MSLDGKYYWD-NVLTPV
LDVDGETQSILCVSRDITLQYLTEQKLKQGSERDELTGLNNRRAFKEKIRKLYSSARDKKQKLAVMLMDLDHFKTINDTLGYAAGDHLLRILSKRLKQIL
EGRAFLARLGGDEFGVIIPHVQDGELNQIAQQILQQLEIPITFSGNYINGGMSIGCGLYPDDANDLSELLKCADTALNDVKAQGRGGMRMFDQDMFNAVR
EQSEQLNCAHQIIRNVAIEAFFQPKVCLDSERIIGYEALLRWRDDQNNIQSPARIAAAFNDYELSSRIGEIMQHQVFKQITEWWAKGLHIVPISINAAPV
EFMRDNFAEIFLKRLKSYRIPSKFVEIEVTEYHLAERGYEVVRALKKLKANGVRIALDDFGTGHSSLTHLRDYPVDIIKVDCSFVQRLSDDKSIYAIVEG
LAKLGPILSMDIVAEGIETETQLQLLRDMGCHIGQGYLFSPPVCAQQAEMQLLK------
>tr|N8YC97|N8YC97_9GAMM Uncharacterized protein OS=Acinetobacter gerneri DSM 14967 = CIP 107464 GN=F960_01579 PE=4 SV=1
---------------------------------------------------------------------------------KLLNPFNYLPHLLGVFKSD
GS-TLLNREWLEMVGNID------N--FF-RIISMDDLQDLVEQLIQLPNSQQKILKEVQLFDIAEKNHWYFIQVKIYFDDVSTKKVILISAINIHNRKT
KHLNFTHQFNMLDISADCIKLLDKDGTLLYVNKNGRKLLGLPPEDATVFNWDLVPLAFKSRC-RNALKLAFSGKSFAKM----ETPEGSKFWN-IRFTPI
VDDNNQTQSVLCISRDITHQINTKKQLQNYSELDQLTGLYNRKIFKNQLKKLLDSAKDQAQQVGLILLGLDYFKHINEMLGHAAGDHLLRVLSKRLITTL
TDKVFIARVGGDEFAVAVNNLENNELYAIAETVAKQLETPISYDGKRINGGMSIGCAIYPHHALDVNGLMRCVDTALHDIKNDGRGGIRFYDEHMLFLSD
QTAKQLHQARNIIQKNWIVPYYQPKVHLLSQKIVGFEALLRWISPSEGLSFPSVLQEAFKDYQLATKISSIMQTKIFADISSWQKQGVDVVPIAINAAPV
EFLRDDYAEKFLLRLEKYKIPAHLIEVEVTEQVLSERSANVLRALRLLKSKGVKISLDDFGTGHSSLSRLKDYPIDCLKIDRSFIQLIEPDKETLAIVQA
IIQLAPKLQLDIIAEGIEKHSELEILIKSGCKIGQGFLFSKAIEANQVVNKLMC------
>tr|A0A022JV43|A0A022JV43_ACIBA Diguanylate cyclase domain protein OS=Acinetobacter baumannii 110912 GN=J547_03543 PE=4 SV=1
---------------------------------------------------------------------------------QKHFIVEQFPLPTWVSDEK
GL-ILCNTECTKYWRDT-SPPLFQQ--WL-DFVYPADLEEVKNKWLDAIRLRSRIEFKCRLLHKTHYYRWCKISIQLSKYHSSQENEWFISFLDINQDIQ
EQQSLRKDIQMLDISVDCIKVLNTDGTVSHMNKSGCLALGIPVDEKFGMRWDLLPPHIRKRG-RVALKKALQGKARFAG----MSCNQEEYWD-NMLTPI
QHTDGEIIQILCVSRNVTQQYLTENRLRDISERDELTGLFNRRSFKLQLKRTLAYSRETQTSVGLLLIDLDHFKHINDTIGHSAGDHLLKILSKRFNQCV
DPERCVARLGGDEFAVIVSHLENNDVRELAEVLLQQLNQPITYAGNVLNGGMSIGCAIYPQDAVDQSNLLSCADMALHDLKARGRGGIRMYNPSMMQLTE
AIASQLNIARQLIRHHTIQPYYQPKVDLKTHAVVGFEALLRWHTTSAQRGLPSQIAEAFKDYDLASKIGEIMQQQVLHDIAKWIKLGFEPLPVSLNAAPV
EFLRDNYAERLLKKINQLEIPTHLIEIEVTEHMLGDRGSEVIRALNKLKQHGVRIALDDFGTGFSSLTHIRDYPIDCLKVDCSFIQKMQHDPSIYAIVQA
IGLLAPNLSLGLIAEGIETPEQEELLLQFGYNIGHGFLFESAIDANQVISILKQ------
>tr|S5EHI5|S5EHI5_SERLI Diguanylate cyclase OS=Serratia liquefaciens ATCC 27592 GN=M495_11950 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------M-KALHPAEYPLIESLWQQAIATATSFVNEVRLRQYNGEYRWFLLSFGAKKKPDSEETDWYLSGTDIHDSVL
EKQRITTTLNMLDASVDCIKVINNDGTLLHINRAGSVALGIDENQQFGMPWNLLQPEVRSRG-KKALRKVLTGKARFAG----LSADGKQHWD-NILSPV
FDNEDRIENILCVSRDVSSQRIAEKRLLIASQYDELTGLPNRRLFKKRLKQEMKRALSSNKSLGLILLDLDHFKLVNDTLGHAAGDHLLRVLSRRLTAYL
NPNSFVSRLGGDEFAIVIGDVENQDIYKIANTFLLQLESPITHGGKALHCGMSIGCALYPQDARDASELMKCADTALYELKDGGRGGVYMFNPQMMDKAK
ERAAQLNHARQIVRDNQIRPSYQPKVSLATGAIVGFEALLRWYCPHHGMKMPDTVVEAFNDYELATKISETMQMKVFADIATWIASGVEVLPVSLNAAPI
EFLRDNYAETFLRRLQMFRIPHHLIELEVTEHAFNKHGSKVLRALQMLKEMGIRIALDDFGTGHSSFTHLMDYPLDCIKLDRDFIRRMNNEPAILGIVES
MGILGQKLSIDIIAEGIETELQRQTLRDSGYHLGQGFLFSQAVEATQVINMLRE------
>tr|A8GEH5|A8GEH5_SERP5 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Serratia proteamaculans (strain 568) GN=Spro_2414 PE=4 SV=1
---------------------------------------------------------------------------------IANEIFDGLPNLIGVGNSL
G--GHFNKLWCEYSGLSSYDNRNTG--WL-KALHPDDYALVDSLCQQAMTTATSFVKQARLRHCSGEYHWFLLSFGVKKAPNSAHNHWFLSCTDIHHQML
EKQIIAEKLNMLDASVDCIKVINNDGSLLHMNKAGSIALGVDENQQFGMPWGLLQPEVRQRG-QKALRKVLSGKARFAG----LSADGRQHWD-NILSPV
FDKDARIQNILCVSRDVSSQRIAEKRLLIASEYDELTGLPNRRLFKKRLKQEMKRSRANNKSLGLILLDLDHFKLVNDTLGHDAGDHLLRVLARRLKADL
NANSFVSRLGGDEFAVVISDVENQDIFKIANNFLLQLETPITHGGKALHCGMSIGGALYPQDARDASELMKCADTALYELKDGGRGGVYMFNPQMMDKAR
ERATQLNHARQIVRNNQIRPSYQPKVNLATGAIVGFEALLRWYCPQNGIQTPDSVCEAFNDYELATKIGETMQMKVFADISAWLASGAEVLPVSLNASPI
EFLRDSYAETFLQRLQMFNIPHHLIELEVTEHAFNKHGSKVLRALQMLKEMGIRIALDDFGTGHSSFTHLMNYPLDCIKLDRDFIRRMNNETAILGIVES
MGILGQKLSIDIIAEGIETEQQRQTLCNSGYHLGQGFLFSQAVEAPRALSMLLK------
>tr|A0A084YYP7|A0A084YYP7_9ENTR Diguanylate cyclase OS=Serratia grimesii GN=CR62_00815 PE=4 SV=1
---------------------------------------------------------------------------------IANEIFNGLPNLIGVGKGL
G--GHFNTLWCEYTGLSSFDHNDVG--WL-EALHSDEYAHITMLQQQSMLSADSFVQEARLRHCSGEYRWFLLSFGAKKDQGSTLVHWYLSCADIHEKML
KKQLTAETLNMLDASVDCIKVINNDGSVLHMNKAGSIALGLDENQQFGMPWGLLQPEVRNRG-RKALRKVLNGKARFAG----LSATGTQHWD-NILSPV
FDKDEQIQNILCVSRDVTSQRIAEKRLLIASEYDELTGLPNRRLFKKKLKQEMKQALSNNTSLGLILLDLDHFKLVNDTLGHAAGDHLLRVLARRLTAYL
NNNSFVSRLGGDEFAIVISDVENQDIFKIANAFLMQLESPITYGGKALHCGMSIGGAIYPQDARDVSELMKCADTALYELKDGGRGGVYMFNPQMMDKAK
ERAAQLNHARQIVRNNLIRPSYQPKVSLSNGAIIGFEALLRWYCPLKGMQMPDTVSEAFNDYELATKLSETMQMKVFTDISGWLAAGIEVLPVSLNASPI
EFLRDNYAETFLRRLQMFHIPHHLIELEVTEHAFNKHGSKVLRALQMLKEMGIRIALDDFGTGHSSFTHLMDYPLDCIKLDRDFIRRMNHEPAILGIVES
MGILGQKLSIDIIAEGIETEQQRQTLCDSGYHLGQGFLFSQAVEAPKVLNMLRQ------
>tr|S4YIM5|S4YIM5_SERPL Diguanylate cyclase OS=Serratia plymuthica S13 GN=M621_12350 PE=4 SV=1
---------------------------------------------------------------------------------IANVIFDGLPNLIGVGKSL
G--GRFNKGWREYTGGASFDNEDSG--WL-KALHPADYAPVHSLWQQAMATAASFVNESRLRHCSGEFRWFLLSFNAAKDPLPGEPRWSLTCVDIHEQVL
GKHILAATLNMLDASVDCIKIINNDGSLLHMNKAGCIALGLDENQQFGMSWGLLPVEIRKRG-RKALRKVLNGRARFAG----LSINGKQHWD-NILSPV
TDKNGRIQNILCVSRDVTSQRIAEKRLLIASEYDELTGLPNRRLFKKKLKQEMKRALSNNKLLGLILLDLDHFKLVNDTLGHAAGDHLLRVLSKRLTAHL
NPNSFVSRLGGDEFAVVISDVDDQDIFKIANNFLLQLESPITHGGKALHCGMSIGCAVYPQDARDPSELMKCADTALYELKDGGRGGIYMFNQQMMEKAK
ARASQLNHARQIVRDNRIRPSYQPKVNLANGAIVGFEALLRWYCPVNGMQLPDTVSEAFSNYELASKISEAMQMKVFADISRWIDAGVEVLPVSLNASPI
EFLRDNYAETFLQRLLMFRIPHHLIELEVTEHAFNKHGSKVLRALQMLKEMGIRIALDDFGTGHSAFTHIMNYPLDCIKLDCDFIRRMNDEPAILGIVES
MGILGQKLAIDIIAEGIETEQQRQTLCDAGFYFGQGFLFSKAVEAPKVINLLRE------
>tr|A0A031R8P2|A0A031R8P2_SERMA Uncharacterized protein OS=Serratia marcescens BIDMC 81 GN=AF54_00329 PE=4 SV=1
---------------------------------------------------------------------------------LYSEIVDDLPGLICFGNRL
G--GYFNKQWRDYTGAIAGEHGAAD--WL-EALHPDDRERLAAQWRQAIVALSSFAGEARLRERSGAYRWFMLAFNARQDGKALEPSWYLTATDIHPQML
QRQQNVQALDMLDASVDCIKVINRDGTLRHMNRSGSLALGLDPAQEFGMPWGLLSPEVRRRG-SKALRSVKAGKARFAG----LSVQGKQHWD-NILSPV
SDEHGAVAEILCVSRDVTSQRVMEQRLLLASEYDELTGLPNRRLFKKKLKQEMKRALHGNKSLGLMLLDLDHFKLVNDTLGHAAGDHLLRVLGKRLSACM
NTHSFVSRLGGDEFAVVISDVENQDIFRIANKFLLQLETPITHGGKTLHCGMSIGGAIYPKDARDASELMKCADTALYELKEGGRGGVYMFDSKMMDKAR
ARASQLNYARQIVRDNCIRPNYQPKVSLADGSIVGFEALLRWHCPQNGIQLPATVSEAFNDYELATKISEAMQLKVFADIARWRAAGVAVRPVSLNVSPI
EFLRDNYAETFLQRLLKFHIPHHLIELEVTEHAFNKHGSKVLRALHMLKEMGIRIALDDFGTGHSSFSHIMDYPLDCIKLDCDFIQRMNTEPAILAIVES
IGILGQKLSIDIIAEGVETEQQRQTLCEAGFHIGQGFLFSPAVGSQQVPTLLQA------
>tr|N9F4E9|N9F4E9_ACIHA Uncharacterized protein OS=Acinetobacter haemolyticus CIP 64.3 GN=F927_02086 PE=4 SV=1
---------------------------------------------------------------------------------VQQNVFNHIPSLVWLLSDQ
GD-AYFNKVSQEYIGINEFQKFQNN--WM-DLLHFEDIAVFQKEWRQAFATKAPFQVECRLRHQSGAYRWFLLSAKFVEADQSGQAHWFINSVDIHETKQ
YQHNLVQCINMLDNSVDCIKLLDLDGYLLHVNRTGCIALNIPENNRFGMKWELLAPEIRSKA-NYALKMVLKGKARFRG----MSGGENQYWD-NLLTPI
LNDKGQIVQILCMSRDVTAQRQTEIQLRISSELDELTGLYNRRFFKLQLKRALQRHKKSEKFLGLILLDLDYFKHVNDTLGHAAGDHLLRILSKRIENTL
PENTFVARLGGDEFAILVNGIEHQELEKIAIDVSRQLDAPITYAGNLINGSMSIGCAIYPRDAKDSSNLMKCADTALNDLKATGRGGFRMFNQQMEIAAQ
NIAVQLNQARHIIRDDLMVPFYQPKVRLSDGKVVGFEALLRWQTDDKHIHSPCHIEQAFQDYVLATRISDAIQNKVFKNIAMWLEQGLAVVPISINAAPV
EFLKDNYAERLLQRLNLYKIPHHLVEIEITEHILDDRGSDVIRALNLLKQQGVKIALDDFGTGHSSLTRLRDYPVDCLKIDCEFIRQMNGDEAILAIVQA
IIALGPKLALDIVAEGIENSDQLELLKQFGCSIGQGYLFSRAVNAQQATHMMKR------
>tr|N9SNM3|N9SNM3_9GAMM Uncharacterized protein OS=Acinetobacter sp. NIPH 1867 GN=F901_02431 PE=4 SV=1
---------------------------------------------------------------------------------VQQNIFNRIPSLVWLLSES
GD-AYFNSLSQEYIGFNDLEHFAKD--WI-DLIHSEDRSIFQSEWQQAFTDKSSFQIECRLKHQSGAYRWFLLSAKFIVANSEEQAHWFINSVDIHETKQ
YQQNLVQCINMLDNSVDCIKLLEVDGSLLHVNKTGCIALNLPQSQSFGMKWELLPVEIRSKA-SYALKTALKGKARFRG----MSGGTEQYWD-NLLTPI
LNDKGQTVQVLCLSRDVTTQRQTEIQLQLSSELDDLTGLYNRRFFKLQLKRALHRHKKDKKLLGLMLLDLDYFKHVNDTLGHAAGDHLLRVLSKRIENTL
PEHTFVARLGGDEFAIVVNGIETEELEKIAVDVSRQLEAPITYAGNLINGSMSIGCAIYPRDAKDSANLMKCADTALNDLKATGRGGFRMFNQQMQVAAQ
NIAIQLNEARHIIRDDLIVPFYQPKVCLADAKVVGFEALLRWQTDDQHIHSPCNIEQAFQDYILATKISDAMQNKVFKNIAGWIAQGLDVVPVSINAAPV
EFLKDNYAERLLHRLNAYNIPHHLVEIEITEHILDDRGSDVIRALNLLKQQGVKISLDDFGTGHSSLTRLRDYPVDCLKIDCDFIRQMNDDEAILAIVQA
IIALGPKLSLDIVAEGIENTEQLELLKSSGCSIGQGYLFSRAVNAKQATEMLQA------
>tr|U7GDA8|U7GDA8_9GAMM Diguanylate cyclase OS=Acinetobacter sp. COS3 GN=Q674_07010 PE=4 SV=1
---------------------------------------------------------------------------------TQQKVFNSIPSLVWLLTEQ
GD-AYFNKISQEYLGFHESESLVKE--WM-ELIHLDDLDVFQSEWSQALPLKSQIQVECRLKHHTGAYRWFLVSAKFVEQCSDQAGYWFVNSVDIHETKQ
FQQNLVKYINMLDTSVDCIKLLEADGYLLHVNKSGCAALNIPESHTFGMKWELLPSEIRTKA-TRALKIALQGKARFRG----MSEGQKQYWD-NLLTPI
LNDQGQTECVLCMSRDVTTQRETEMRLRIASELDELTGLYNRRFFKLQLKRSLHKHKANKKLMGLMLLDLDYFKHVNDTLGHAAGDHLLRVLSKRIENIL
PDNTFVARLGGDEFAVVVNGIDSSELERIALEVGKQLDAPITYAGNLINGSMSIGCAIYPRDSKDSVNLMKCADTALNDLKATGRGGFRMFDQYMQIAAQ
NIAIQLNEARHIIRDDLIIPFYQPKVSLSDGKVVGFEALLRWQTSDHQVHSPSNVEQAFQDYALATKISDAIQNKVFKDMSIWMEQGLEIVPISINAAPV
EFLKDNYAERLLHRLNLYKIPHHLIEIEITEHILDDRGSDVVRALNLLKQHGVRIALDDFGTGHSSLTRLRDYPVDCLKIDCDFIRRMNQDEAILAIVQA
IVALGPKLSLDIVAEGIENTEQLELLKRSGCTMGQGYLFSQAVNMQRAKQMLTQ------
>tr|N9F9Z7|N9F9Z7_9GAMM Uncharacterized protein OS=Acinetobacter beijerinckii ANC 3835 GN=F934_02126 PE=4 SV=1
---------------------------------------------------------------------------------IEKNIFDNIPSLVWLLTEQ
GD-AYFNKLSQEYIGTQELHQLING--WD-NVIHPEDSILYKNEWLQAFIHKNEFQFECRIQHHSGTYRWFLLSTKFIENTDIEKKYWFINCADIHETKQ
HQQNLVKCINMLDTSIDCIKLLEVDGTLLHINKSGCTALNISENNHSKMKWDLLPAEIRSKA-ARALKVAAQGKSRFRG----MSTGNKQYWD-NLLTPI
LNDTGETLRILCISRDVTSQKETEMRLQIASELDELTGLYNRRFFKSQLKRTLLKHKNNKKCLGLMLLDLDYFKHVNDTLGHAAGDHLLRILSKRIESIL
PANTFVARLGGDEFAIVVNEIEDSDLEKIAIDVNKLLDAPITYAGNLINGSMSIGCAIYPLDSKDSSTLMKCADTALNDLKATGRGGFRMFNSHMLVAAQ
DVAIQLNKARHIIRDDLIIPFYQPKVRLSDAKVVGFEALLRWQTSDNQVHFPKNVEQAFQDYVLATRISDAIQNKVFADISTWMKQKLQLVPVSINAAPV
EFLKDNYAERLLHRLSQYKIPHHLIEIEITEQILDDRGSDVVRALTLLKQNGVRIALDDFGTGHSSLTRLRDYPVDCLKIDCDFIRRMNHDPAISAIVEA
IVALGPKLSLDIVAEGIENIEQLELLKLSGCTIGQGFLFSQAVSHQQATLMLGK------
>tr|N8PV25|N8PV25_9GAMM Uncharacterized protein OS=Acinetobacter sp. CIP-A165 GN=F991_01791 PE=4 SV=1
---------------------------------------------------------------------------------VQQNVFNSIPSLVWLLSDQ
GD-AYFNSVSQEYIGLNELEKFKKN--WM-DLIHSDDISVFQSEWLQAFSYKTPFHVECRLKHRSGAYRWFLLSAKLVANNSGDHAYWFINSVDIHETKQ
YQQNLVQCINMLDNSVDCIKLLDVDGCLLHVNRTGCIALNIPESNRFGMKWELLAPEVRSKA-NYALKTALKGKARFRG----MSGGEDQYWD-NLLTPI
LNDNGQVVQILCLSRDVTAQRQTEIQLRISSELDELTGLYNRRFFKLQLKRALQRHKKSEKFLGLMLLDLDYFKHVNDTLGHAAGDHLLRVLSKRIENNL
PENTFVARLGGDEFAILVNGIDAFDLEKVAIEVSRQLDAPITYAGNLINGSMSIGCAIYPRDAKDSLNLMKCADTALNDLKATGRGGFRMFNQQMQVAAQ
NIAIQLTEARHIIRDDLMVPFYQPKVRLSDGKVVGFEALLRWQTDDKRIHSPINIEQAFQDYVLATRISDAIQNKVFNNIAMWIEQGLAVVPVSINVAPV
EFLKDNYAERLLYRLNLYKIPHHLVEIEITEHILDDRGSDVIRALNLLKQQGVKIALDDFGTGHSSLTRLRDYPVDCLKIDCDFIRQMNSDEAILAIVQA
IIALGPKLSLDIVAEGIENAEQLELLKQFGCSIGQGYLFSRAVNMQQATHMLKR------
>tr|N9DFN6|N9DFN6_ACIBZ Uncharacterized protein OS=Acinetobacter bereziniae CIP 70.12 GN=F938_02162 PE=4 SV=1
---------------------------------------------------------------------------------EVKFALDQVPHLIWMTKFG
E--GYCNTALKQYFGIDHNEIDAHQ--WM-EFLHPEDRALMQNIWMKAYKTGQRFEQECRIRRHDGKYQWFLLNAQSALYQ-KQYFDWTITCSNIHERLS
KLQETQQLLDMLDASVDCIKIISPDGYVLHMNKSGSLALLGQEKVSFGMEWGLLPPEVREQG-KKAIKEAAKGKARFAG----KSINNVMYWD-NILTPI
VNAQGQTTSILCVSRDITKQRIAEEKLRLNSEFDEMTSLMNRRVFKKRLKSSISKARDSRGKIGLLLLDLDHFKHINDTLGHSAGDHLLKVLSKRLANCL
DEHAYIARLGGDEFAVVVENVENQKIETVSKKLLKQLEAPITYTGKLLNGGMSIGGAIYPDDAKDGSGLLKCADTALNDLKERGRGGVRMFGADMLETAQ
RKAKQLHTARYMIRSNQVEAFYQPKVKLDDCSIIGFEALLRWRDVEGEVYFPSTVAEAFNDFELATKISEIMHDRIFTDMSHWMNLDLKVVPISINASPV
EFMRDNYAETLLKRLTNYAIPAHLIEIEITEHVLADRGYEVVRALKKLKHAGVRIALDDFGTGHSSMSHIRDYPVDSLKIDYNFVNRMHEEDSIKAIVEG
IAKLGPILSLDIVAEGIETTQQLDSLIAIGCKFGQGFLFSQAINADQVQKMLGK------
>tr|A0A072CV29|A0A072CV29_9GAMM Diguanylate cyclase OS=Acinetobacter sp. ETR1 GN=DT74_16460 PE=4 SV=1
---------------------------------------------------------------------------------EVKEALDLIPHLIWVTKLG
I--GYCNTPLKEFIGVDTHNICDSD--WI-KCLHPDDAEHIYNIWITAQKTGQRFEKECRIRHVNGDYQWFLLIAQSTVYK-QQFFDWTITCTNIHERAT
LLRETSESLDMLDVSVDCIKIITPDGYVSHMNKSGCIALLGQEKVTFGMEWGLLPAEVREQG-KKAIKEAAKGKARFAG----KSVGNLMYWD-NILTPV
VNENGQTTSILCVSRDITKQRIAEEKLRVICEFDEMTSLMNRRAFKRRLKASISKARENRSKIGLLLIDLDHFKHINDTLGHSAGDHLLKVLSKRLAHCL
DENAYISRLGGDEFAVVIDHVESAQIEAVSKKLLQQLDAPITYSGKLLNGGMSIGGSIYPHDAKDGSGLLKCADAALNDLKERGRGGIRMFGVDMFEIAQ
SKAKQLNTARQIIRNNQIEPFYQPKVKLDDCSIIGFEALLRWRDVEGNVYLPATVAEAFNDFELATKISETMHDKIFTDISHWIKQGFNVVPISINASPV
EFMRDNYAEILLKRLTQYAIPHHLVEVEITEHVLADRGYEVIRALKKLKQEGVRIALDDFGTGHSSMTHIRDYPVDSLKIDYNFVNRMHEEKSIKAIVEG
IAKLGPILSLDIIAEGIETIQQLENLRAVGCKFGQGFLFSQAICAEQVQEMLQ-------
>tr|N9MM72|N9MM72_9GAMM Uncharacterized protein OS=Acinetobacter sp. CIP 53.82 GN=F905_01077 PE=4 SV=1
---------------------------------------------------------------------------------DFIRAIEMMPQLIWVSSAG
H--HLYNSNFKQYLASDEQSLTAQS--WL-NAIHPEDAEHLCFLWESAQKSGQSFEKECRIRDRQQRYHWFLLIARNSQQL-EGCDQWMISCTNIHDSAV
KYRETKDTLHMLDVSVDCIKIVKPDGSLSHMNRSGCQALLGKERENFGMKWDLLPPEAREKA-QQAIREVIKGKSRFPG----MSIQDEKYWD-NMLTPV
LNEHGETTSILCVSRDVTLQKIAEDKLRLSSEVDDLTKLINRRTFRKKTKQAIQVAKETRTLVGVMLIDLDHFKNINDTLGHQAGDHLLKVLSKRFQKYI
SEQVSIARLGGDEFAVVVHSVENQQLIELAKKFAKLLDAPITYSGRVINCGMSIGCSMYPKDAREIPELMKCADTALNDLKAGGRGGIRMFDHSMLAAVQ
SKAEQLQTARMIIREQRIVPFYQPKVCIETGELIGFEALLRWQDAQQRYRYPKELLEAFSDYELTTKISELMQQAIFSDLQSWIKQGLQTVPVSINASPV
ELMRDNYAEVLLKRMQHYQIPAQLIEIEITEQSLAERGSEVIRTIHKLKQAGIRISLDDFGTGHSSLTHLRDYPVDSLKIDCDFVNRINSDKSIQAIVEA
IIKLGPVLSLDIIAEGIETKEQFETLKQFGCHFGQGYLFSNAVNQLEAKQMLKA------
>tr|A0A031LNN1|A0A031LNN1_9GAMM Diguanylate cyclase OS=Acinetobacter sp. Ver3 GN=CL42_10155 PE=4 SV=1
---------------------------------------------------------------------------------DFKFALDLLPNLIWVSHTN
S--GYCNIALKQYIGADTQILRDVD--WL-KFVHPDDAEHLYQIWNDAQKNGQKFEKECRIKNKSGEYLWFLMLAEPKVIQ-SNQQNWMISCTNIHDRTI
KMRETAEALDMLDVSVDCIKIITPDGKLEHMNKSGCMALLGQERVKFGIDWTLLPPEVREQG-AKAIKTAARGKARFAG----MSTGDTMYWD-NILTPV
HDEQGNTTSILCVSRDITRQRVAEAKLKISSEYDDLTGLMNRRAFKNKLKAAISQANREKTLIGMMFIDLDHFKNINDTLGHPAGDHLLKVLSKRLQKSL
DCKCIVSRLGGDEFAIIVPGMTSEELHQTTQKVLKQNIAPITYAGKVINSGMSIGCAIYPKDAQDVFGLMKCADTALNDLKEKGRGGYRMYDDEMFALAE
KKMQQLDTARYIIQDNLIEPYYQPKVRLDNCQLIGFEALMRWHDTQQQLQYPASISEAFNDYELASKISEIMHQKIFSDMADWMSKGVQLVPISINASPV
EFMRDNYAELLIQRLERHQIPAHLIEVEITEHILSERGVEVIRALQKLKNYGLRISLDDFGTGHSSMTHLRDYPVDCLKIDYAFVNRMNEEKSINSIVEG
IAKLGPILSLDVIAEGVETCQQLLSLQDVGCAYGQGFLFSQAICKSEAEQLMLK------
>tr|N8ZR86|N8ZR86_9GAMM Uncharacterized protein OS=Acinetobacter gerneri DSM 14967 = CIP 107464 GN=F960_01581 PE=4 SV=1
----------------------------------------------------------------------------------LFQTYELLPMSVNIFLID
GQ-NINNKQWKNHIGESE------F--FY-SIIHPDDFLTLKSAIQ-NNAQDDVNQFECRILCQDHGYQWYVLRINSFFMDEIQQQVFITTAANIQNKKI
GQVSLLEQLNMLDVCVDCIKVLDTDGNVKHMNLSGRKALGVPLDEKFGMKWDLLPIEVRGRG-KKALIEAVKGQARFAG----KSVAGIQYWD-NILTPI
VDENGQTQTILCVSRDVTLQKEAENKLRENSELDDLTGLYNRKLFKNRLKRLISDAKDKQQMAGILLIDLDHFKHVNDTLGHSAGDHLLRVLSKRLQLVS
DDQGFVARLGGDEFAIAVGGLKSQEFSKIAELASQQLDAPISYSGRLINGGMSIGCALYPRDAEDSAGLIQCVDTALNDLKADGRGGIRFYNEQMLINTE
ITAKQLNRARNIIRMDMVTPYYQPKVDLITRKIVGFEALLRWESPELGLQMPNEVREAFKDYKLASKISELMHNKIFEQLAQCIENDLNVVPVALNVAPV
EFLRDDYAEKLLQRIDKYNIPYHLVEIEVTEQILEERGSDVLRALEILKRKGVRIALDDFGTGHSSLTRLRDYPVDCLKIDKSFINLIATDRTILAVIQA
ITELGPKLNLDIVAEGIETEEQLNILVESGCHIGQGYYFSQAVDLQGMIEILRK------
>tr|N9MSS0|N9MSS0_9GAMM Uncharacterized protein OS=Acinetobacter sp. NIPH 2171 GN=F897_00492 PE=4 SV=1
---------------------------------------------------------------------------------LLQDLINDVPHPLWVLGKD
NI-EYFNQALSDYLGTNLSEYGPKE--WQ-SLIHPDDQPAFSEQWHTALNQQQGFNTQCRIKSADSSYRMCALAIKFQHTA-EHLLQWSVSLTDIHEYFE
IQQQLSQVINMLDASVDCIKVMSPQGEIRHINQSACHKLGIDPEQPAPHSWSLLPAEVKKTG-QRALKQAAQGLSHFVE----KAQNEDQYWD-HLLTPV
LDENNIPQNILCVSRNVSQQKIAESRLKTVIQRDELTGLYNRNAFYKTFKQVLLKAKQQQIMVGLLLIDLDYFRHINDTLSHIAGDHLLHVLGKRFQACF
GSNNIVARLGGDEFAILVKNLENAQLINTAQLAYAQLEQPVSYVGHRMSIGMSIGCTVYPRDAQNSSNLLKCADIALNDLKNSGRGGIRMFNQEMFRSLE
NMTKQLTLARKIIHADQIIPYYQPKVRLSDGEVIGFEALLRWQDQQHQIQLPSHIFSAFQDYDLASRISETMQLKVFEDMSRWQAEGLDILPISINAAPV
EFLRDDYAEKFLARLSRFDIPAHKVELEITEQSLSEGGANVIRALNLLKKHGIHISLDDFGTGHSSLTRLQEYPVDCIKIDRNFVERMNNDPSALAIVKA
ITQIGSSISLDVLVEGIENTEQLDTLINCDCQIGQGFYFYRPMSGSSAQQLLQQ------
>tr|N9PNZ9|N9PNZ9_9GAMM Uncharacterized protein OS=Acinetobacter sp. CIP 51.11 GN=F894_00308 PE=4 SV=1
---------------------------------------------------------------------------------LLKNLIDALPQPLWVSNKK
HL-QYFNDALTDYLGVNLNEQGHPQ--WQ-SFIHAEDLQLFLAQWHAALDHHQNFETQCRIKRSDTHYRMCTLAVKFHHEP-EHLLQWAVSLTDVHDYFE
IQQQLSQIVNMLDASADCINIISPEGEIRHSNQSGCLAQASETQNDRSLCWNRLTPEARKSG-QRALKQAAQGLSRFSS----KVQDQPQYWD-HLLTPI
LDQQNITQNILCVSRNISQQKIAETRLKEVIKRDELTGLYNRSTFYKTFKQVLLKAKQQQTMAGLLLIDLDYFRHINDTLGHIAGDHLLHVLGKRFQTCF
GPNTIIARLGGDEFAVLVKNLESEQLLATAQMAYAQLDQPINYVGNSISSAMSIGCAIYPRDALNTSNLLKCADIALNDLKNSGRGGIRMFNQEMCGSLE
NMTKQLTLARKIILADQIIPYYQPKVRLSDGAVIGFEALLRWQDQNQNIQLPSEIFGAFQDYELASRISETMQLKVFADMSRWQAQGLDLLPISINAAPV
EFLRDDYAEKLLARLSNFDVPAHKVELEITEQSLSEHGANVVRALNLLKQAGIQISLDDFGTGHSSLTRLQDYPVDCIKIDRNFVERMNSDPSALAIVKA
ITQIGSSIALDILVEGIENTEQLDTLIHCDCQIGQGFYFYRPMAGASAQALLHP------
>tr|A0A0A3W256|A0A0A3W256_9GAMM Uncharacterized protein OS=Acinetobacter sp. HR7 GN=GW12_15850 PE=4 SV=1
---------------------------------------------------------------------------------LIQQFADALPHPVWVQTQN
NE-AYFNQAMTDYLGIDLNQHGSEK--WQ-QFIHPDDLNNFTQEWHAALNVRQNIEIQSRIRKPDNSYRMCLLSMKFHHAV-QSPLYWAISLTDIHDYFE
IQQQLSQMINMLDASLDCIKIITPDGKLSHVNRSGRQALGLSENEEFGMPWDLLPPEVRASG-KRALKRASQGLARFSG----KSQDQEEYWD-NLLTPM
MDEHNVPQQILCVSRNISQQRQAETRLKAIMERDELTGLYNRRTFYKFFKRTLYKAQQQQGQVGLLLIDLDYFKHVNDTLGHIAGDHLLHVLGERFQKNL
DPEAIVSRLGGDEFAVLVPNIQDSRLIDVAKQVCQQIEQPIKYAGRSINGGISVGGAIYPRDANNSSNLLKCADIALNDLKSSGRGGIRMFSQEMFESLD
KMTRQLILARKIINSDQIVPYYQPKVRLSDGAVIGFEALLRWQDQKHQIQLPSHIFSAFQDYELASRISETMQLKVFEDMTRWQQQGLEILPISINAAPV
EFLRDDYAEKLLERLSRFDIPADKVELEITEQSLSERGANVIRALTLLKEAGINISLDDFGTGHSSLTRLQEYPVDCIKIDRNFVMRLNTDPSALAIVKA
ITQIGSSIELDVLVEGIENNEQLSTLITCDCQIGQGFYFYRPMSGEAAQQLLRS------
>tr|N8XYI8|N8XYI8_9GAMM Uncharacterized protein OS=Acinetobacter schindleri NIPH 900 GN=F965_01202 PE=4 SV=1
---------------------------------------------------------------------------------CIQDFADALPQPMWLQTRD
EI-EYFNTAMQDYLGIDLNEYGREY--WQ-QFIHPDDLSNFIREWHTALNKRQNAELQCRIQKLDHGYRMCLLNMKFHYET-GSLLHWAITLTDVHDYFE
IQQQLSQIINMLDASLDCIKIMTPDGKLSHVNRSGRQALGLSETEHFGMSWNLLPAEVRSSG-KRALKRAAQGMARFSG----TSQGQAEYWD-NLLTPI
VDEHNVTRQILCVSRNVSQQKQVETRLKAVTEIDELTGLYNRGTFYKQFKRVLFRARQQQSQAGLLLIDLDYFKHINDTLGHIAGDHLLHVLGERFKNNL
GPEAIVSRLGGDEFAVLVQNLEHSQLLEVAKKVCQQMQIPISYAGRSINSGISVGGAIYPRDAINSSNLLKCADIALNDLKNSGRGGIRMFSQEMFESLD
KMTRQLILARKIINSNQIIPYYQPKVRLSDGAVIGFEALLRWKDQHHQVQLPSRIFCAFQDYELASRISETMQLKVFEDMTQWQEQGLEVLPISINAAPV
EFLRDDYAEKLLERLSRFDISADKVELEITEQSLSERGANVIRALNLLKQAGIHISLDDFGTGHSSLTRLQEYPVDCIKIDRNFVERLNTDPSALAIVKA
ITQIGSSIELDVLVEGIENTEQLSTLINCDCQIGQGFYFYRPMAGSAAQQLLHS------
>tr|N9DUN0|N9DUN0_9GAMM Uncharacterized protein OS=Acinetobacter bouvetii DSM 14964 = CIP 107468 GN=F941_00084 PE=4 SV=1
---------------------------------------------------------------------------------PPHSFMDDLHLPIWIKTQH
SS-PYFNSAMAQFMGLEQKPVNDEQ--WL-QYIHPEDLEHLIILWRTATLTSKSFHKDCRVKHAKLGYRMCSLQINFPAAE-QPLYQWLLSITDIHEEYE
KQLLLSQQIKMLDASVDCIKILTPDGKVMHMNRSGCLALGISADEKFGMPWNLLPGDVRTAG-EKALHLAASGQARFAA----KSLGQEQHWD-HILTPI
IDENGATQQILCVSRNISPQMIAEEKLQHVIEEDQLTGLLNRRAFNKLFKMTLQDAQNRQQQVGLLLIDLDYFKHVNDTLGHTAGDHLLVTLGQRFQNCF
DEQI-VARLGGDEFAILVPHLKSEQLLSIAHQAWMQMELPISYTGQSINGGMSIGCSIYPGNAQNASNLLKCADIALNDLKSSGRGGIRMFTQSMFEALK
VTTKQLTLARSILKLDSIEPYYQPKVLLQDGRVIGFEALLRWHDQEGQLQLPCNIFAAFHDYELASGISDTMHRKIFKDIRQWMADGMEVMPISINAAPV
EFLRDDYAEKLLKRMHAYGIPHHLIEVEITEQSLSEHGADVIRALNLLKAAGIQISLDDFGTGHSSLTRLRDYPIDCIKIDKNFVERMTNDQSALAIVKT
ISQLGSSIALDILVEGIETTEQLEILKSCNCLKGQGFYFYMPMNHSDAEQLLPR------
>tr|N8QGX9|N8QGX9_9GAMM Uncharacterized protein OS=Acinetobacter bohemicus ANC 3994 GN=F994_00580 PE=4 SV=1
---------------------------------------------------------------------------------MSQALLDELPQLIWVKSKQ
NQ-YYYNQAMCQYIGKNLNQQDINF--WQ-KFVHPEDFEHFIVLWQHSLLTQQDFEKECRIKHAQKGYRFCLISVQHQHKN-LNNFAWMVTVTDIHEHYL
KQLQLTQQIQMLDASLDGINMLTADGLVSYMNRSACLALNISVNEKWGMPWNLLPESMQNSG-QHALHHAQKGEAHFDG----VKVGQPQYWD-HTLTPI
LDKNGLTQSILCVSRDISPQKIAEKKLKQVIELDELTGLYNRRAFNKIFKKTIQNARQQQQSVGFLLIDLDYFKHINDTLGHIAGDYLLQILGQRLSGCF
KSGVVVARLGGDEFAIIVPNLSDSELLQIAKTARLQLDIPICYAGQYINGGMSTGCAIYPRDAQNSSTLLQCADVALNDLKISGRGGIRMFKSSMFKAIE
LATKQLALARAIIQNDKIVPFYQPKVRLTDAKVIGFEALLRWYDKEGRIQLPSHIFSSFQDYELATRISEIMQLKVFQDMTQWLASGMQLLPISINAAPV
EFLRDNYAETLLNRLAQFNIPYDMVEIEITEQSLSERGSDVIRALNLLKKAGIHISLDDFGTGHSSLTRLRNYPVDCLKIDRNFIENMHDDPSAMAIVKA
ISQIGASISLNILVEGIEHLEQLDALKACDCHIGQGFYFHRPMAFDHITALLQP------
>tr|N9PJE6|N9PJE6_9GAMM Uncharacterized protein OS=Acinetobacter sp. NIPH 1859 GN=F889_02327 PE=4 SV=1
---------------------------------------------------------------------------------VQQNIYNSIPSLVWLLSEQ
GD-AYFNSVSQEYIGFNNLEHFAQN--WV-DLIHSDDISLLRNEWEHAFCSRLPFQLECRLKHRSGSYRWFSLSAKFLNAEVEGQGYWFVNSVDIHETKQ
YQQNLVKCISMLDNSIDCIKLLEADGSLLHVNKTGCIALNIQENNRFGMKWELLPLEMRSKA-TYALKTALKGKARFRG----MSGSTEQYWD-NLLTPI
LNDQGQIEQVLCLSRDITTQRQTEIQLRLSSELDELTGLYNRRFLKRQLKRALHRHKKDEKLVGLMLLDLDYFKHINDTLGHSAGDHLLRILSKRIENIL
PENTFVARLGGDEFAIVVNGIDTAELEKVAIDVSRQLDAPITYAGSLINGSMSIGCAIYPRDAKDSSNLMKCADTALNDLKAAGRGGFRMFNPQMQIAAQ
NIAIQLNEARHIIRDGLMVPYYQPKVRLSDSKVVGFEALLRWQTEDQCIHSPRKIEQAFQDYSLATKISDAIQNKVFKDIAMWIEQGLDVVPVSINAAPV
EFLKDNYAERLLQRLNLYKIPHHLVEIEITEHILDDRGSDVIRALNLLKQQGVKIALDDFGTGHSSLTRLRDYPVDCLKIDCDFIRQMNEDDAILAIVQA
IIALGPKLSLDIVAEGIENIKQLELLKLSGCSIGQGYLFSAAVNVQQATAMLQH------
>tr|A0A009H720|A0A009H720_ACIBA Diguanylate cyclase domain protein OS=Acinetobacter baumannii 1295259 GN=J507_1972 PE=4 SV=1
---------------------------------------------------------------------------------QKHFIVEQIPLPTWVSDEN
GL-ILCNIECTEYWLDT-FSPLPAQ--WL-DFVYPADLDEVKNRWLEAIRLQKRIELKCRLLRAGNQYRWCKLSIQASKYRSSQTSEWYVSFLDIDHDIQ
EQQNLQKNIQMLDISVDCIKVLNVDGTLSHMNKSGCLALGVPVDEEFGMKWELLPPHIRKRG-RVALKKALQGKARFAG----MSCDQDEYWD-NMLTPI
HRENGEIGQILCVSRNVTQQHLAENQLRNMSERDELTGLYNRRSFKFQLKRTLSYSKDTQTSVGLLLIDLDHFKHINDTLGHSAGDHLLKVLSKRFNHCV
DDEKCVARLGGDEFAVIINNLNSNDVRELAAILLQQLNQPITYLGNVLNGGMSIGCAIYPQDAVDQSGLLSCADMALHDLKARGRGGIRMYDPCMMQMTE
TVASQLNLARQLIRHHTIQPYYQPKVDLNTHRVVGFEALLRWHTTSAQRGYPAQIAEAFKDYNLASKIGETMQHQVLRDIAKWINLGITPLPVSLNAAPV
EFLRDNYAERLLKKINQFQIPTHYIEVEVTEHMLGDRGSEVIRALNKLKQHGVRIALDDFGTGFSSLTHIRDYPIDSLKVDCSFIQKMQHDPSIYAIVQA
IGLLAPNLSLGLIAEGIETQEQEELLRQFGYSIGQGFLFESAIDATQVISILKQ------
>tr|A0A085JF81|A0A085JF81_9ENTR Diguanylate cyclase/phosphodiesterase OS=Tatumella ptyseos ATCC 33301 GN=GTPT_1913 PE=4 SV=1
---------------------------------------------------------------------------------FKDVFFDSVPLPAWIISGC
GQ-EVANQQWHKTMSLPP-VMSEPH--WM-HWLHPQDKARISAAWERSIQHSDVFRQPVRLGVAAGSYYWFIACGHFIP----ARNLWLITFIDINELQE
AREDITQHLSMLDASIDCIKLINLQGELINMNLSGCKALGVSP-EGFGMDWNLLPPEIRTRG-RKALKLANTGRVRFSG----KSQENKFYWD-NILTPL
QDPQGGVTSILCVSRDITRLHQAEQRFKFISEHDELTGLPNRRMFNTTLKKYLRQAGHHNRPFALVLIDLDYFKLVNDTLGHPAGDYLLKSVANRLKKSL
CRDAFVARIGGDEFAAVLPGIGDQSLLEAGDKLIADTTEPLTYQGQTIYTSLSMGGAIFPQQAADSTAMIKAADIALNELKKNGRGGVLCYDPAMSDVVD
TTRGQMELAKQLIYDEAILPFYQPKVRLEDGKIIGLEALMRFFNSQGELCFPGDIWSAFENYALVERIGYIIRDKVFADIRCWIDSSLDVVPVSVNASPV
EFMRDNYAEKVLQQLEHYRIPPALLEIEITEHMFDGRGAGVFRALNLLKAQGVRISLDDFGTGYSALANIRDYPVDVIKVDRSFVASLSKGKEGLAVIKA
LWLLATELELDVVAEGIEEPGQRDALIREGYLLGQGFLFSMAVPADVIAGFLNN------
>tr|I3IB20|I3IB20_9GAMM PAS fold family OS=Cellvibrio sp. BR GN=O59_001933 PE=4 SV=1
---------------------------------------------------------------------------------RVHHLAEGLPHLAWTCTPD
GA-CDLNQRWCDYTGIPKAEQMGTN--WI-NAVHPDDREYLARNWAKAVANREEMFVKFRIRRNDGHYRWFDTRAIPQKNSQGDVLRWLGTNTDITEMES
TRQALAHSEAAFDYAPLGMALINMQGIIIQTNPALRHLLGYDN-QKTQTASDLFIAEDITNA-LVELERLYSGNAQYET----RCQNGNSIPT-MINAAY
IKEFSGEPCYLLQIYDLSERKRYEHQLLKLAHFDSLTGLGNREKMNREIEFLIRKASRSTAPFAVIFGDLDHFKQINDGLGHEAGDILLKTVARRLQKSL
RHEDIICRLGGDEFVILLPDIPREAVASVADKLLQKIHKPIRLGKNRVHVSMSFGIALYPTDGDDAKTLLRNADSALYDAKAKGRGCYQLYRKELTEYVH
NRLQLDADLRKAIINHEFEVHYQPVIDLDTNQVVSAEALIRWNHPKRGRVGPDEFIPYAQESGLILPIGNWIINEACHQLAQWNSEGIH-INISINVSAR
QFMQQDLLPVFEQMLEQYNLRGDQLTIEITEQMFLENTENNLRQITQLKNLGIKISLDDFGIGYSSLSYILRFSPQYLKIDRSFVSLIGTGKEHDEMVNA
IIGLNKIIPMHIVGEGIEEENQRHFLHSRGCDLGQGYLFSKPVPPDQLAHFINS------
>tr|B3PKH8|B3PKH8_CELJU MorA OS=Cellvibrio japonicus (strain Ueda107) GN=CJA_2447 PE=4 SV=1
---------------------------------------------------------------------------------RFIELTEGLPHLIWTCLPD
GR-CDLNQRWCEYTGQSQEQQLGYG--WL-EQVHPEDRAPLLKAWADCVNSGTPLSIKFRIGRYDGEYRWFDTRATPLLDDKGNLIRWLGSNTDINDVET
MRLALANSEAAFDYAPLGMALVSLDGQILQSNAAFNQLVMATA-QGDHASWDEL------HE-QEYLRALQQDEAHFEK----RLFQGQAIDT-QVSVAL
INTDHQQPCYLYQFQDISERKRYEEELLKLAHYDTLTGLGNRRKLLSEMEFLIQKSHRASAPFALLFGDLDHFKHINDNLGHEAGDLLLRRIARRLQKGL
RRGDNVYRLGGDEFVVLLQDVNREAVITVAEKLIQLIKRPIRLNNHAVHAGMSFGIALYPTDGDTPQTLLRNADSALYEAKTKGRGSHQLYRKELTDYVH
NRLMLDADIRKAIHNQEFELYYQPVVNLNNHHVEYLEALIRWHHPVRGLVSPGDFIPYAQENGLINRIGEWVINDVCRQAEDWHTKGIT-LPIAINISAR
QFNQHNLGQLIQHALAEHHLQGQQLILEITEQLFMENAQDNIRQIEELKAMGLRISLDDFGVGYSSLSYVMRFAPHYLKIDRALIEQIDQAKQQQRMLQA
IIDLQKIIPMTIIAEGLETEAQQHFLIECGCGMAQGYLYSHPLPARDVPGLLQQ------
>tr|Q1H2A5|Q1H2A5_METFK Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Methylobacillus flagellatus (strain KT / 
--------------------------------------------------------------------LVQVETALRKQDVQLRTILDNLPLCAICFDVE
FCCQFVNLSFCDDFGRTPEQWAGAR---LASM-MPEDWLRLEPAMR-QALSGKQANIHFAVRGANDEILYKNISRRGMTDPHGSTTGVLVLVTDCTEQEL
MSQKLMAKEKIALDAHAIVAVTDARGVITRVNDKFCSISQYGREELVGSTHRIVNSGHHPKEFFQHLWRTVSSGQVWNGEVCNRAKDGTLYWVHTTIVPF
LGEDGVPVQYIAIRADITQRKILEQSVQRMALYDDLTGLPNRRLMVERLQMIREACVRSHRHGAVMFLDLDNFKEINDTHGHEQGDRLLKQVGQRLRENI
RQVDTVARAGGDEFIILLADLDEAKAYNVAEKLRNALSTPYIFNRIVLHTSTSVGIVMFSDKAKPKTELFKHADMALYRAKAQGKNRISMFDPSLQAEVL
EYASLLADLRQALQRDEFRLYFQPVVNRD-GKVIGHEALIRWIHPVRGMVLPGQFIPVAEQTGLIQEIGQWVLSMACKQLNVWSEDAVKSWTLSVNVSAK
QFRDMDFVGKVHDAIRQSGADPKRLWLELTESMFHTDIVQTIEKMRALQDIGVHFSMDDFGTGYSSLSVLKLLPLDQLKIDRSFVRDVIDDPNDAAIVRT
ILALAGILNLTVVAEGIESSEQFDFLEQHGCQAFQGYFFGKPVPMDEETQASG-------
>tr|C6WYQ8|C6WYQ8_METML Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Methylotenera mobilis (strain JLW8 / ATCC BAA-1282 / DSM 17540)
--------------------------------------------------------------------LSELTDSL-LSTEVIQKVLDYLPSMIGYWDKN
LKNRFVNKAYELWFGVDVSQIVGMH---ISSL-LGEELYRNLPYIN-GALNGEFQEFERVIPNKDGSH-SRHSLAHYIPDRAGEVQGFFVLVTDISAIKE
AEKVLRQSESVVQDQTEVISRLRADGTYLFVNDVYCRFFGKTEQEMIGSTWKPVVYAEDLQRVVDELAMLSSSNPVVMIENRVLSGTGDVHWMQFSNRGI
FDEYGQLTEIQSVGRDISDRKRAEEEVQKLAYKDPLTGLSNRRLMLDRLRIALATSARSMQYGALLFLDLDKFKVINDTQGHADGDLLLVEVAKRITACV
REIDTVSRQGGDEFVVLVERLGEEEVAKIAETIRLTLAEPYQINNAHIHSSSSIGISLFCGHDQDVDELIKRADMAMYQAKDGGRNRTRFFDPQMQELVE
VRATLESDLHNALATDQFELHYQLQVNHE-NKPIGAEALIRWVHPQRGMISPAHFIPVAEESALILNIGDWVLDEACRQIAVWSTNAKMCLVLAVNISAQ
QFKQAHFVDQVIAAIHKHGIDPSRLKLELTESVALDDITDVIAKKNLRQKVGVTLSLDDFGTGFSSLSYLKRLPLDQIKIDQSFVRDITTDKSDAVMVKT
IIDMAQNFSLNVIAEGVETEAQLAFLKHHECKAYQGYLFSKPLPIEQFDALMQ-------
>tr|A0A0A1H3X9|A0A0A1H3X9_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Burkholderiales bacterium GJ-E10 GN=E1O_02510 PE=4 SV
---------------------------------------------------------------------------------RLTMVARNTKNGVLICDVD
RRILWANAAFEAMTGYSLAEVIGKK---PGSLLQFDQTPATVRQLHEALASGQGAHVQILNRSRHGRTYWLDLDIQPVHDENDRHVGFIGVETDVTERVL
AHRRLE---SVLDGTGAGTWEYDVPSATTVVDRRWLRICGDTPTTTAPVRIGSLRAHEDDLARYAAQFRDHLDGTTFDCELRVRHRDGRWIWVHDRGRIS
RKRDGTPLRVLGIRIDVTGRKEIELAALAAANADSVTGLASRSLFVHRLGAAIDRTCRHRAGFCVLLLDLDRFKVVNDTLGHPAGDAVLRTIAGRLQAVL
WESFLAARFGGDEFAVLLEGVPDGEAVRIAQRILASINEPYTIERQEIRMAASIGVVGSEHCDEGADAVLRDVDTAMYNAKRAGRGRVAAFDPGMRRKVA
REFQIEAELRKAIGTPQLSLVYQPIVSLDTEAMQSVEALVRWNHPELGGIAPAEFIPIAEESGLIVSLDEWVQRQACRQWRKWQTEHPQPRGVSVNISRI
QMGFPNALVHVDQLLTENAMPTGALQLEVTERDVMRDPDAVLVLMQRLRDMGVRLAMDDFGTGTSSLACLRQYPFDCVKIDRSFIADLAIAPDMRALTRA
SVMLIESLGKHSVAEGVEDPLQVEILRSIGCRSAQGYLFGVPLPPDRILAWPDP------
>tr|F3KRD9|F3KRD9_9BURK Diguanylate cyclase/phosphodiesterase OS=Hylemonella gracilis ATCC 19624 GN=HGR_05081 PE=4 SV=1
---------------------------------------------------------------------------------QLALVAERTANWVAMLDGA
GRVLWCNDAFLRGKGLPREQVIGVQ---GVL-LGQADDEAREQALLEELRQGRPVRTEILHRAADGREVWLDVDYQPIRGAEGEPQGCTLVATDITEAQS
QRLRLR---AAVESAALGVWQWDFASGRLEVNERFYALLGYASGSLE-LTARTLLIHPEDLDAMSRALRANLRDSRVHVQMRVRHADGRWRWMLFSGTVS
RDGRGRAARMAGVCYDVSAQKELEEQLRQSARIDSLTHLPNRAELLRRIRAALDRARREPYGFAVLFMDFDRFKQVNDTLGHSAGDELLRQIAGRLQESL
RAQQLAARIGGDEFVVLLDNIRSLDAKVVATRLLQTLAEPYEIGGHRVSSTASIGIVTPTHMADDPDSVLRDADIAMYEAKRQGRGRYELFEPSLRKRVH
DDAELENDLRQALARDEIRVVYQPLIDLATGRLASVEALARWHHPKRGLISPLAFIPVAEGSGLIGPLGERVLRTACHELVRLRQMLGDPQTVSVNVSRA
QLRQTDFVARLSELLRSTGIGPEALMLEVTESLAAQ-DEGVQSVLREVSALGVALSLDDFGTGYSSLSCLHALPVNQVKVDRSFVSEALDSNYHRVMIEA
TIRMAKALHLQTVAEGIETLEQAALMQYLGINKGQGYLYSHPLNAGELEAWAGQ------
>tr|W0RNV3|W0RNV3_9BACT Diguanylate cyclase OS=Gemmatimonadetes bacterium KBS708 GN=J421_4493 PE=4 SV=1
---------------------------------------------------------------------------------FATSLVASVSDGIYAFDDD
QRVTEWNPSMERWTGVERRDALGRR---LDDFDAEIDWEH--GKPYERAIGGEPTHVHECRGSRDAEWRFFDAVCVPVRSSDGRIAGGLCTIRDVTERVA
TVARFR---A-----------IDDDGIIHAVNPAFERLVGWSAAELIGRR---AFSPPEDAIITRGPVAELRAGRRVTVEKRFVHREGAQIWCSLTISRF
RTNHDDAVTLVGMCYDVTARKELETRLSHQAFHDPLTGLANRARLLDRIHHTLAAPDRLPSNVAIIYVDLDDFKKVNDSLGHAAGDTLLRAVAERLLNAT
RGSDTVARLGGDEFAILLENVRSDDVLVVADRVVRAMRAPVTIDGKEIFVGASVGVARDETERPTADVLLRNADVAMYRAKGAGKGRHVMYERGMQEAAL
ERLELEAALRTAVSGDELLLHFQPIVELDGERVVGVEALVRWAHPQLGVLPPARFVPLAEETGLIVPLGRWVLREACRHGAGWVRSLDRSLTLTVNVSPL
QLRDPGFVDDVRDALRDSGFPPHLLLLELTETVFLQEDEGTLETLRALKALGARLAIDDFGTGYASLNYLQQFPLDVLKIDRRFIDAMCRGGSEAALART
IIALGDSLALRTVAEGVARPQQQEQLRALGCEYGQGFLFAHPVPPEEITRMLNE------
>tr|O67220|O67220_AQUAE Uncharacterized protein OS=Aquifex aeolicus (strain VF5) GN=aq_1151 PE=4 SV=1
-------------------------------------------------------------------------QMRKKGTETLRLLLDNLPDVVVVLDSN
FKINFINKTGEEKLKFKREEVVGKP---FTELLPERYRGVYRLLCELCKMKGSGTLPEVVYLGNPKLAILKPFEVSYQTLSVNGETFFIIDLRDVSEEVK
KERERQRISRLYSHLIKIFEETEKEEIFRKIADFLVDEENFTYAEITLDGHTIIKKGKM-----GEYSVCFKL----------K--SKEKYYLTLSEEEF
--YPAEVQLIINFLEELSDAITAHEKLEKIEFFDKLTRLPTRIFFVKALSDRLSIAAQERKKVVVVVLDIDNFTAINTLYGTEVGDKVLIEVADSLRDSV
RIGDILARLGADTFGVALTCADVVAVNSFLARLNKLFSKPVIVNGKEIQVTFSIGISVFPDDGNEAEKLLGYALQAMFEAKKLGGNRVVYYSSKEFPKIE
EIITKKKELLEAIKKDEFILFYQPKIDLKEKKIVGCEALIRWKKG-DKLVPPYEFIPLLEETGLMNEVGLIVLEKACRQLKEWHKKGIE-IEIAINISPA
QFRSGEFLQSFLKDLEGYTELLYYLGVEVTETALVENVSVATLFLKSLSELGIRVYIDDFGTGYSSILHLKQLPVSALKIDVEFVKDMDVNERDYEIVKG
VINLAHSLGLKTVAEGVEKEIHEKMLMELSCDYAQGYYYSPPLPPEEFEEFFRKF-----
>tr|A8UVB3|A8UVB3_9AQUI Uncharacterized protein OS=Hydrogenivirga sp. 128-5-R1-1 GN=HG1285_16201 PE=4 SV=1
-------------------------------------------------------------------------RILKSGEKKYQTILDAVNDGVVIVNLS
KRIVDINRKMEELLGLEEKDVVGRE---IFWLYPRELEDTMRHRCKLYIEKGEGV-SGIFYIENKSSGEWIPVELSLGRYEFDESDYAVVVFRDIRERLK
HEETMRKLSRLYEAVNTITTVKDTDYLFKTVADILRNKGGFKYAGVFTANGTLHEEGEF-----GSMSACIPI----------GEDGKHHYIVVAYDEAF
--TEDEAELLREIAHDVSRKVSSEERISYLTLNDPLTGLPNRTNFINRLNEALSRAKAHGDEVGLLLIDIDHFKELNEALGHTVGDEVLKEVARRIREVV
RSSDFLARVGGDEFGVIVNSEEANAIDKLIKRILKQFSKPIPVNGHSVFITLSFGGSIFPQDVDNSEILFSNAMASVEKAKELGGNRLVMFSRGVSKATE
EKIKVRTNLRYALERGEFRLFYQPKVDLKTGTVVGAEALLRWLRT-GEVVPPGKFIPILEEGELIHRVGEWVIEEALKQSERWKEAGLS-VPIAVNLSPL
QLKVPSFAEQFLTTIETCDCDFCNIEIEITESAVMEDVALSVELIKALKEKGIKTYIDDFGTGHSSLAYLKKLPVHGLKIDMEFIRDIPEDKEDLEIVKA
SVLLAHTFGMIAVAEGVEKEEQRKVLRELGCDQAQGYLFLPPVPPEEFERYLEDK-----
>tr|A0A072NFG0|A0A072NFG0_BACAZ PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Bacillus azotoformans MEV2011 GN=M670_04517 PE=4 SV=1
-------------------------------------------------------------------------RNIKNSERKYRLLVDHSPMGIMTVQ-E
DKITFINKSGYQTLGADDSEVVGRN---VHDFINPEIKASIKK-DELIEEKGKRIDENDIDL----EMVLIPLNT-------VLNNNELIIFKDITEKIQ
SKTEAENI---YKNLKSIVEVVDKKGRIVYVNDKFCNISKYSAEEVIGKTHQVKNKAKD-----GSYVQTIIV----------PFNS---------GEP-
-------YQFITIRNDITARKEAEKEIKLLATHDHLTHLTNRRKFEYELQQ----AIRKHNSVAVLFIDLDRFKYVNDTLGHSIGDNLIKAVAKRLKGIV
EKDAIVSRQGGDEFTILVNYRD-NSIEIIAKEMIDRIKQPYMIEQKEILITCSIGISIYPEHGNDIETIMKNADVAMYWSKDKGKDGFSFYEPHMKEKSV
RIMQLELELRKAIDNNEFILYYQPKIDLKTNEISGCEALIRWNHPTMGMVSPAEFIPLAEETGLISQIGEWVLREACLQNRKWHEAGYT-NIMAVNMSAH
QFKQPTMIGMIERILHETNHEAKHLEIEVTESVSMLSEEVIMSQLYALKRLGVSIAIDDFGTGYSSLKYLDMLPADVLKIDKSFIDEIGRMNHSSLMTNA
IISLAKSLKMKVVAEGIENIDQIHYLKLHNCEYGQGYLISKPLPACELEMKFMRS-----
>tr|Q2RWY3|Q2RWY3_RHORT Diguanylate cyclase/phosphodiesterase OS=Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIB 8255 
--------------------------------------------------------------------------------------------------SA
GKILSVDKTLWQALGLSAESLSGLP---FLSFLEDPSREVLAARLR---LAGPPWDLRTALR-VDGRAIPVVLRGDGAADTDTPLQVI-----LITLAPQ
EPVSQS---ALFDHIPLGVMLSDGLGRIAYANPAFLAEDIAAVRALLGATPQALATGYLHEGLARTLWEDLLCGRVWRNDVDLPTADGQRTHSRLTIIPL
RRDDGAVDRLMTVIEPR--SPATDSQAWQQVNHDTLTGLPNRVLFQDRLLTALASARRRNDQLAVLFVDLDHFKTVNDSLGHSFGDQLLQQVATRLSQCL
RDSDTLARMGGDEFTIALTGDGHRDYAMIANRILETLRRPFTLEGHEVLIGSSIGITLFPNDAEDVDTLLRNADTAMYRAKASGRNAFQFFTEEMNREIQ
SHLDLENALRRAVRAMDLTIHYQPVVDSATLAVVSAEALVRWPLADKGFIPPSRFIPVAEELGLIDEIGGWVLWNACTQAKVWQAQGAKAFRVSVNVSWR
QLRNPDFALRVREALEGTGLGAAFLELEITEGMVLRDPQGIAPALMALSEMGVALAIDNFGSGHSSIKCLRQFPFSILKLDRSCVADVLTSHEDAVLVET
AAIMARRLGLTVVAEGVETHAQLEFLREHYCDLIQGYLFGRPLPPEDFARML--------
>tr|H6SS18|H6SS18_RHOPH Rhodospirillum photometricum DSM 122 draft genome sequence OS=Rhodospirillum photometricum DSM 122 GN=RSPPHO_01071 PE=4 SV=1
--------------------------------------------------------------------------------------------------QD
GRLLFLNQTLSLLLGLDTAQGIGTM---FVDLVREEDREILTGHLS---DAGRFWELTARL---AGSERPVIVKGSVAASSDAPVALL-----S--VRPG
VDGPLR---SVLDQMPFPIMMTSPMGVIEYVNPAFLRNLGYEAHEVLGRTPRFLKSGTMNETIYEKLWADLAAGRQWSGEIQNRRKDGSLIWERTTIVPL
RDATGAVVHYMAVHEDISQRKAAESRSWHHANHDALTGLPNRILLRDRMTLAVAHARRAGSRVAVLLVDLDHFKVINDTLGPIVGDTLLCQVTQRLRECL
RDTDTLARVGGDEFLILLVTEGGVDQALVARRILEALRRPFVLDGQDVMIGGSIGITVSPDDGESVDELMRNADTALARAKESGRNTYQFFTSEMNREVQ
EQISLEGALRRAVRNMDLTVHYQPVVDSQTLLVVGTEALIRWPSAEGGFVSPTRFIPVAEDLGLMEEIGAWVLWTACTQARQWLNRVPPGFRMAVNLSWR
QLRNPDFPQRVVEVLEGTGVPASVLELEVSEATLSRDPKPIGRTLQALKECGVSLTIDNFGSGHGSMKTLRAYPFGSMKLDRHCVADMLTRHEDAVLVET
AILMARRLGLRVVAEGVETEAQLAHLRAQYCDLIQGFLFGHPLAPEDLVALL--------
>tr|E0U619|E0U619_CYAP2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cyanothece sp. (strain PCC 7822) GN=Cyan7822_5247 PE=4 SV=1
--------------------------------------------------------------ISD---RKQTELALRESEERLKTIISTNPNGLLILDLQ
GKVLFVNPAAEILFGRKQEDLMGQILG-IPIIVN-NY-------------------SEIEILQPSGKLIIVRMRLVKIIW--QEKNAFLASLVDVTDIQQ
AQEQLKILYQATEQSPVSVVITDAEGTIEYVNPKFEKITGYQRAEVIGQNPRILKSGETTTEEYKQIWKTITSGQEWHGEFHNKKKNGELFWEAASISPI
KNAEGIITHFVAVKEDITERKAQQTTLTYQANYDALTGLPNRFLAIDRLKQAILQADRQKKRVAVMFIDLDHFKDVNDTLGHEYGDLLLQKVSQRLKQCL
RKSDTVARLGGDEFLIILPNLREHHCKLIASKILSSLEKPFNLLTEEAFISASIGITLYPDDGNDVSVLMRNADAAMYLGKRGGRNDFKFYTMGMNEEAQ
SRLRIEKLLRYALKKNEFYLVYQPIIDLRFQTVIGAEALLRWNNPELGRVSPDQFISIAEETGLISELGAWVISQACQEVVNWQTQGSP-IWVAVNLSPR
QFRESKLLEIISNAITLNGITNHYLELEITEKLLLEDFPGSKGIIEQLHEMDFRLSIDDFGTGYSALSYLIKFPFNRLKIDRSFIADIPHNQEVLALVKT
IIAMGHGLKLQVIAEGVETTEQANILEAEGCDYAQGYFFSRPLLSEEFRRYLQSHQNP--
>tr|U5NAN6|U5NAN6_9BURK Signal transduction protein OS=Candidatus Symbiobacter mobilis CR GN=Cenrod_2399 PE=4 SV=1
------------------------------------------------------------------------------CESLLQAVFENAAVGMVMATPQ
GRFLRVNQHFCDLLQRTREELLGTTLD-CRALTDPRDRAATESALQWAMQSNPRFRLEKRYCRPDGSTLWVSQAAQLVRTPQGEPDHLFVVVQDIQERKS
AEQALLLAASVFTAAREAIMITELDGTIVDVNESFTRITGYERAQALGQNPRMLKSGRQNDAYYRNLWTSLQRYGHWHSEIWNRHKNGELFASMQTISLV
RDEHGQPRHYVALFSDITAVKRHQQQLEHMAQFDALTGLPNRALLADRLQQSMLAVQRRDLYLATVYLDLDGFKAINERIGHDAADGVLAALAARMRTVL
REGDTLARVGGDEFVAVLADLPDASCAPMLDRLLAAAMEPVPSHGETIQTSASLGVTFYPQDSIDAEQLLRQADQAMYQAKVAGKNRYHLFDAEHDRNVR
GKHESIERIRHALLQNELVLYYQPKVDMRTGQVIGAEALLRWQHPRRGVLLPGAFLPDVENDPFAVELGEWVLRTAVRQVQEWLAQSVD-LCVSVNVGAR
QLQQSHFVDRLRNILARFDLPQGRLELEILESNALEDLEGISQVIMDCEALGVSFALDDFGTGYSSLTYLRRLPVKTIKIDQSFVRDMLEDADDLAILTG
VIGLAQAFHREVIAEGVETVDHGTALLQLGCPLGQGYGIARPMPAAAIPIWVRE------
>tr|Q5P8Z7|Q5P8Z7_AROAE Azoarcus aromaticum EbN1 complete genome OS=Aromatoleum aromaticum (strain EbN1) GN=ebA163 PE=4 SV=1
-----------------------------------------------------------------------------ESRRQLAEATLLAHVGYWEWQLP
AGVLHWGEQTDRLLGHAPGKVTPSG-ATFLAHVHPDDRERVAGEFAGAVRNQCSYVSEFRLIRADGALRIARANGHLQYDREGRAVRVCGAIQDITELRA
TETALRNSEIAMTAAPFAVAITRVDGRFVEVNDKYELHFGWKREELIGKTSTNLWPDPESRQRWL---EMLRQHGSVLDETLGCERNGAVRQVSLSSR-Y
IDIDGE-KHVLTFVHDITDRKEAQARIEYLAHHDALTGLPNRVLFRDRFALATAWAERAHAKVALLFVDLDHFKTINDTLGHPVGDGLLQGVALRLRECL
RETDTVSRLGGDEFLIALTDIRDQAINSATAKIFDTLTRPFELEGHELTNTMSIGIAIWPDDGEDFDTLLKNADTAMYQAKRAGRNTWRFYTEQMNANAV
EQLQLRTALHSALENDEFLLHYQPQINLASGHVVGVEALLRWHWDKRELVPPDRFIPAAEESGLIVPIGDWVLREACMQAVRWTRQGLPELTIAVNLSAV
QFRRGDLERSVVRALSLSGLDPARLELELTESLLLVDTESVIETLRRLKSLGVRLSIDDFGTGYSSLAYLKRFAVDKLKIDQSFVRDIATDPDDAAIVRA
IVSMAHTLKLQVIAEGVESEDIDRFLHIFNCDEAQGYHYARPMPGDALAEWLVA------
>tr|A9DCR1|A9DCR1_9GAMM Sensory box protein OS=Shewanella benthica KT99 GN=KT99_07513 PE=4 SV=1
--------------------------------------------------------------------FKRINTALVESEERLRQSLKGSNSELWEWRQD
SQMFSLENQWAEKED-DRGNIILRL---EGFPIHREDRD---QVLNASMLKGDRFDVEYRHRREDKSWGWTRVSGRPVEVESGRILRVAGIYSDITLQRQ
LEDDVKLLAQAFGNTSEGVLIMDAAERIKVSNKAAQTIVGASDKQLNGKFFILVKEGRAD-----EIVHLLQQGVSWTGEREFLREQGGPCPVWLNVSAM
LGSKGNITHYVAVFSDITERKRTEADLRRLANYDVLTGLPNRSLFSTRLAQSIHSAEHSGEKLALIFLDLDRFKHVNDSYGHSMGDALLVEAANRLQSCI
TEEHTLCRFGGDEFVILLRDASNDTINHICAQLLEQIKTPFELYGREFFISTSIGVSLWPDDARQAEVLIKNADQAMYHAKEEGRGNFQYFSSERNLEAL
YHLRLEAELRKAIERDEFELHYQPQVDILKDKLIGMEALLRWRHHEDGLVRTDIFIKVAESCGLIVDIDRWVLRQACLQGVIWSQSYDEIFKLSVNISAV
HFRQADFIEGVKKILAETGLDPHLLGFEITEGVLMKELDTAKEHLRELRVLGIEVAIDDFGTGYSSLAYLRHFDVDTLKIDRSFLVDIATNEADQAIASS
IIELARNLKLNVVAEGVETKEQLEQIFSRGCYVIQGYYFSKPLI----------------
>tr|W7SG77|W7SG77_9PSEU PAS sensor diguanylate cyclase/phosphodiesterase OS=Kutzneria sp. 744 GN=KUTG_00057 PE=4 SV=1
---------------------------------------------------------------------------------VHNHVLRWADVGFGVTDLH
GKLNWANPALGTLIGVPADQALGRS---LPAL-LPGAPEGP---D---------PGMVVQAEGDEHRWLEISC--TALPG--GDEL-LYR-IMDITSWRD
RELEATQQARAQVLGRMGNWEWDITTDRVLWSDALLEMFGLEPGTELD--FAGYMGKVHADMIATSLAVARANGDRFTFSHRMLVGV-DERFFECFGEVI
CDEDGTPVRMMGTCHDVTQDRRLQDELRQLAEEDPLTGLPNRRALTRELERQLAAGG----TGSLLLLDLDNFKDVNDLRGHAVGDRLMRTMAAALRERL
EPGQLLGRLGGDEFAVVLPGCEEQDASEVAARLRDAVALPLVAGGATTRMTVSTGVAGFT-SGEGWEAVLANADLALYASKNAGRNRVTVYDPGHYADTA
KRVSVQDRLRKALEHGDLALHAMPIVALSSGRTLGYELLLRLEDGQLPLLGPADFLPAAERSDLVLEIDRWVFGKAIDTLVAHPDP---NLRFDVNVSGR
TLEDEDFADFVLDRLASSGVAPGRLGFEITETAAVTNLDAARSLAHQVRATGCRIALDDFGAGFGSFVHLKHLPITGLKIDGEFVRGIDSGTRDAVLVSG
ILEIARGFDLSVVAEWVERPAQVEVLSKLGVSVGQGFHLGKPKPLGSVLK----------
>tr|W5WAD8|W5WAD8_9PSEU Uncharacterized protein OS=Kutzneria albida DSM 43870 GN=KALB_4338 PE=4 SV=1
---------------------------------------------------------------------------------VHNHVLHCADVGFGVTDLH
GRLHWANPALGTLVGVPADQAIGRS---LTAL-LPGAPETP---Q---------TGLVLQTDGAPHRWLEINC--TPLPP--GGEL-LYR-IMDVTAWRD
RELEATQQARAQVLGRMGNWEWDMATDRVLWSDGLLELFGLEPGTELD--YAGYIQLIHPDMIEHALGVAGESGDRFAYTHRMLVGG--ERVFECFGEVI
CDDRDQPVRMMGTCHDVTQDRRLQDELRQLAEEDPLTGLPNRRALTRELERHLATGG----TGSLLLLDLDNFKDVNDLRGHAVGDRVMRTMASALRERL
HEGQLLGRLGGDEFAVVLPGCPESEAAHVAARLRDAVALPLVAGGTTTRMTVSTGVAGFS-SGEGWEAVLANADLALYASKAAGRNRVTVYDPAHYADTA
KRVSVQDRLRKALDRGNLALHAMPIVALDSGRTLGYELLLRLEDGQLPLLGPADFLPAAEKSDLVLEIDRWVFGKAIDALVAHPDP---NLRFDVNVSGR
TLEDEDFADFVLDRLASSGVAPGRLGFEITETAAVTNLDAARNLANQVRATGCRIALDDFGAGFGSFVHLKHLPITGLKIDGEFVRGIDTGGRDAVLVSG
ILEIARGFGLSVVAEWVERPAQVEMLAKLGVSVGQGFHLGKPRPLRNVLP----------
>tr|K0JZY1|K0JZY1_SACES Saccharothrix espanaensis DSM 44229 complete genome OS=Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NB
---------------------------------------------------------------------------------LHREVLDRADVGFGVTDGE
GVLRWVNPALARILGVAVDRVAGRS---LPAL-LPGVPERP---R---------SGLALLAVREDHRWLEVTC--QPLERD-G-GL-LYR-VADVTAWRD
RELEATHEARAQVSGRMGTWEWHIAEDCVVWSDTLLEMFGLPPGTRMD--FGSYASLVHPETVRAALEEAMRSGAGFSYTHRVVVAGRRERWFECFGEFV
LDGDGTPVRALGTAHDITGARRVHDELRALAEQDPLTGLANRRAVTRELERRLGAGG----SGALLLLDLDNFKDVNDLRGHAVGDRLMKTLAGALRSRL
SPPQTIGRLGGDEFAVVLPGCSAAEAAVVADGLRDAVALPLVAAS--AHVTVSTGVAEYG-SGDTWELVLANADLALYASKAAGRNRVTVYEPGHYADTA
KRVSVMDRLRAALDGGGLALHAMPMVQLSTGRTLGHELLLRLEDGQEPRLGPAEFLPEAERSNLVLDIDRWVLSTAIDTLVRHPDL---DLRFNVNVSGR
TLEDEDFGGFVLDRLATAGVAPGRLGLEITETAAVTNLDAARALAVQLRGFGCRITLDDFGSGFGSFVHLKHLPITGIKIDGEFVRGIDERSTDAVLVAG
IVEIARGLGLSAVAEWVERPAQVATLIGLGVRVGQGFHLGRPVPLAQILS----------
>tr|C6W9U5|C6W9U5_ACTMD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064
---------------------------------------------------------------------------------WHREVLQRTDIGYGVTDPA
TTLRWANPALAGILGIDPEHLPGRS---LSAL-LPGAPDRP---R---------PGLALLTAGEGHRWLEVTC--QRLDAS-GGDL-LYR-VADVTAWRD
RELEATHEARAQVLGRMGTWEWHIAEDRVEWSDTLLGMFGYPAGTALD--YAAYTGHVHPDTIQSTLTEALRTGAGFSYTHRMTLGDGVERWFECFGEVV
TDPDGTPQRVLGTAHDITQSRRVHDELLALAEQDPLTGLANRRAVTRELERRLATGG----TGSLLLLDLDNFKDVNDLRGHAVGDRLMRALAAALRTRL
EPEHLIGRLGGDEFAVVLPDTGPADAARVAEHLRDTIALPLATPA--TRTTISTGVAGYGTSGDTWELVLANADLALYASKAAGRNRVTVYEPGHYADTA
KRVSVLDRLRGALDGGGLALHAMPMVRLATGRVLGHELLLRLEDGQEPRLGPADFLPEAERTNLVHEIDRWVLATAIDTLVRHPDP---ELRFNVNVSGR
TLEDPEFGGFVLDRLAGAGVAPGRLGIEITETAAVTNLDAARTLAHQLRGHGCRIVLDDFGSGFGSFVHLKHLPITGIKIDGEFVRGIDERGPDAVLVSG
IMRIAQGLGLSAVAEWVERPEQVRTLTSLGVRVGQGFHLGGPVPLGQVLS----------
>tr|F8AWV0|F8AWV0_FRADG Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Frankia symbiont subsp. Datisca glomerata GN=FsymDg_3012 PE=4 S
---------------------------------------------------------------------------------MAGSVADVVSTGLLVVTSD
SRVVWANRALLDLVATGGGAAVGRD---SADATPAGTADGG---Y---------PSRQAQWD-GTTHWLEVRA--RTLIGGIADSFVLYE-ITDVTERRH
EEETLRLREHVETIARTGIWEWDLVTNEMEWSDELLAMLGYPTDTRID--YDAFRLLVHPDTVEDAFDQAITTVTPVEVTLRMYLADRVECVLEWRGDVL
TGDSGTPIRIMGTAHDVTELVRIRHELAHVSVHEPLTEVLNRRAVTVLLTERLATGVD--RTGALLLVDIDNFKIVNDLRGHSVGDTVMRSVAQRLAETL
P-AAAIGRLGDDEFAVVLHSGDGLEALAVADTLREQVAYAIMVDGFAVRVTVTVGVVPLSAVG-DCDTALAHAGLALTEAKEAGRNCAKLFTAERHEYLT
RRALMVQRVRDALDAGLLTLQVQPIVDLASHEVQGYEVLLRLHDGQHPEIGPAEFMSVLAHSDLVLSLDRWVVQQTVAALASVRGE---RLRLHVNISGR
SVEDAGFADFVLSELRAARVDPSQLGIEIAESVAVAAADAVRQLAETLTGAGCRFTLDDFGVGLGSFVYLRNLPFTNVKIDGDFLRHVDTSPADAVLVDA
VVRVARCLGMYTIAESIDRESLAPALRDLGVDYAQGFHLGPPRPLTELLA----------
>tr|A0A090F889|A0A090F889_9RHIZ Diguanylate cyclase OS=Mesorhizobium sp. SOD10 GN=MPLSOD_40326 PE=4 SV=1
---------------------------------------------------------------------------------FWALALDRAHLGLWDWNLS
AGDCYYSPTWSKMLGYEAGEL---------KLTHPDDRQRA---Q---------EETELRLRHKDGHWVWVLD--RGGIVEDGKPLRLMGVQTDITRQKE
AEAALEQVNLALAASGTGIWHFDIGTQKSYWDARTREIFGLESDTDVT--AGLWHTYLHPDATERAHLPPPDSQGVTASQYRIIRRDGEESLVRFIADV-
----GSAGQILGTVRDVTEEKQRAEGLAFAACHDALTGLLNRSAFDRLLAENIALAER--LPLAVFYVDLDYFKALNDYAGHAAGDLALKSVAAGILASL
PTSAHAARLGGDEFALMVPNCKDACAEQIARAVLAAVRADLGPAVSSRRLAASIGIAFVRDRNMSVADALACADDACYAAKAGGRDRFAVFSPETTAGAL
NAARLAADLVDAMEDGRLKLFGQEIHRLGQPDSRHVEVLARLEARTGSMIPPGDFMPVAERFGLAARLDRWIIRTALTRHGE-RAG---AVSLDFNLSAQ
TLSDPRLWDFVDEAIAESGAPPSAVGFEITETAAVTNFDAAEAFVRRARERHCRVSLDDFGAGMSSFEYLRRFPIDAIKIDGSFVEHIAESRFDREIVSA
ITGIARSMGAAVVAEKIEEKNAFEILMGMGVAYGQGYFLHRPEPLEAIVA----------
>tr|A0A090EGP3|A0A090EGP3_9RHIZ Diguanylate cyclase OS=Mesorhizobium sp. ORS3324 GN=MPLB_940003 PE=4 SV=1
---------------------------------------------------------------------------------FWALALDRAQLGLWDWNLA
TGDCYYSPTWSRMLGYAEGEL---------KLTHPDDRERA---L---------AETELRLKHKDGHWVWVLD--RGGIVEEGKPLRLMGVQTDITKQKE
AEAALEQVNLALAASGTGIWHYDIATNKSYWDARTREIFGLVSDTDVT--ADLWHTYLHPEATERAHLPSPGSEGVTATQYRIVRRDGAESLVRFIAAA-
----GSAGQILGTVRDITEEKKRAQELAFAAHHDALTGLLNRAAFDRLLAENIGAADR--LPLAVFYVDLDYFKALNDYAGHAAGDLALKSVAAGIVASL
PPSAHAARLGGDEFALLVPNCSDACAERLARAVLAAVRADLGSAISSRRLAASIGIAFVHDRNITVADALACADDACYAAKAGGRDRFAVFSAETASGAL
NAARLAAKLVDAMADGRLKLFGQEIHRLGSPDSRHVEVLARLEGRNGKLIPPGDFIPVAERFGLAARLDRWIIRTALMRHGK-RSG---AISLDFNLSAQ
TLSDPQLWDFVDATIAESGAPASAVGFEITETAAVTNFDAAEQFVRRARERHCRVSLDDFGAGMSSFEYLRRFPIDAIKIDGSFVEHIADSRFDREIVSA
IARIARSVGAAVVAEKIEEKSALEILMGMGVAYGQGYFLHRPEPLEAIVA----------
>tr|X6CI05|X6CI05_9RHIZ Diguanylate phosphodiesterase OS=Mesorhizobium sp. LNHC232B00 GN=X742_27840 PE=4 SV=1
---------------------------------------------------------------------------------FWAKALERAQLGVWDWDIR
TGDCFYSATWAHMLGYSEDEL---------QLTHPDDRKHA---L---------AETELRLKHKLGHWVWVLD--RGGIVESGRPTRLMGVQTDISKQKA
AEAELEQVNLALAASGTGIWHYDIATNKSYWDARTRDIFGLVAGTDMT--ADLWHSYLHPDATERAHLPPPGSDGVTASQYRIIRRDGEESLVRFVAAA-
----GAAGQILGTVRDITEEKLRQQELAYAARHDALTGLCNRAAFDRLLADHIAA--G--VPLAVFYVDLDYFKALNDFAGHAAGDLALKSVSAGIRGCL
PQAAHAARLGGDEFALLVPHCDASQAERIATAVLGAVRADLGTAALSRKLAASIGIAFIDDASTTVADALACADDACYAAKAAGRNRFAVFSTIVESGSL
NAARVAADTVDALEDGRLKLFGQEIHLLGKPESRHVEVLARLAGRNGRLVPPGEFIPVAERFGIASRLDRWIIRTALSRYGA-RSG---ALTLGFNLSAQ
TLSDPQLWAFVDSVIDETGVPHSGIGFEITETAAVTNFDAAEQFVRKARERRCRVSLDDFGAGMSSFEYLRRFPVDTIKIDGSFIEHITESRFDREIVLA
ITSIARSLGCDVVGEKIERQDTLAMLGDMGVAFGQGFLLHRPEPLEQIVA----------
>tr|G6YIT2|G6YIT2_9RHIZ Diguanylate cyclase OS=Mesorhizobium amorphae CCNWGS0123 GN=MEA186_29537 PE=4 SV=1
---------------------------------------------------------------------------------FWALALERAHLGVWDWDLK
SGACYYSPTWSKMLGYGEGEL---------QLTHPDDRERA---K---------AETELRLRHKDGHWVWVLD--RGGIVENGQPLRLMGVQTDITRQKE
AEAALEQVNLALAASGTGIWHHDIGTHKSYWDARTREIFGLVADTDVT--ADLWHTYLHPDATERAHQVPLGSDAVIASQYRIVKRDGEESLVRFIAT--
----GAAGQILGTVRDITEDKKRAQELAYAANHDALTGLLNRAAFDRLLADHIATSRR--LPLAVFYVDLDYFKALNDYAGHAAGDLALKGVAAGIVGSL
PPSAHAARLGGDEFALLVPNCATKQAERLAGAVLAAVRADLGT-MTSRKLAASVGIAFVADHNTTVADALACADDACYAAKAAGRNRFAVFSPETASGSL
NAARLAADLVDAMEDGRLKLFGQQIHLLGKPESRHVEVLARLIGRNGRMIPPGEFIPVAERFGLASRLDRWIIRTALSLHGQ-RSS---AISLGFNLSAQ
TLSDPQLWDFVDAAIAETGAPHSGIGFEITETAAVTNFDAAEQFVRKARERRCRVSLDDFGAGMSSFEYLRRFPVDAIKIDGSFIENIAQNSFDREIVSA
ISGIARSLGCSVVAEKIEQQAALEILEGMGVAYGQGFLLHRPEPLEAIVS----------
>tr|X6GMN5|X6GMN5_9RHIZ Diguanylate phosphodiesterase OS=Mesorhizobium sp. L2C084A000 GN=X734_29740 PE=4 SV=1
---------------------------------------------------------------------------------FWAKALERAHLGVWDWDLV
TGDCFYSATWARMLGYDESEL---------QLTHPDDRERA---L---------AETELRLKHKQGHWVWVLD--RGGVVEMGKPLRLMGVQTDISKQKA
AEAELEQVNLALAASGTGIWHHDLATGKSYWDERTREIFGLVSDTAVE--RDHWFGYLHPDAASRAHLVPLETDKVTAVQYRIVRRDGEESLLRFIADPQ
IPDRRLAGQILGTVRDITEDKQREQELAYAARHDALTGLWNRAAFDRLLADHIAAAQR--LPLSVFYVDLDYFKALNDFAGHAAGDLALKSVAQGILGCL
PSTAHAARLGGDEFALLMPNCDTAQAGRLADAVLAAVRAELGSTAKSRKLAASIGIAFVDDANTTVADALACADDACYAAKAAGRNRFAVFSTDTASGSL
NAARVVADTVDAMEDGRLKLFGQEIHRLGRPESRHVEVLARLAARNGRLVPPGEFIPVAERFGIASRLDRWIIRTALSRHGA-RSG---ALTLGFNLSAQ
TLSDPQLWDFVDNVIEETGAPHSGIGFEITETAAVTNFDAAEQFVRKARERRCRVSLDDFGAGMSSFEYLRRFPVDAIKIDGSFIEHITQSRFDREIVLA
ITSIARSLGCDVVGEKIERQDTLAMLSDMGVAFGQGFLLHRPEPLERIVV----------
>tr|Q98JP5|Q98JP5_RHILO Mll1848 protein OS=Rhizobium loti (strain MAFF303099) GN=mll1848 PE=4 SV=1
---------------------------------------------------------------------------------FWAKALERAHLGVWDWDLR
SGDCFYSATWARMLGYEEDEL---------QLTHPDDRERA---L---------AETELRLKHKLGHWVWVLD--RGGIVEDGRPLRLMGVQTDISKQKA
AEAALEQVTLALAASGTGIWHYDIATHKSYWDARTREMFGVVADADVA--ADLWHSFLHPDATERAHWPSPGSNGVTASQYRIVKRDGEESLVRYVAAA-
----GAAGQILGTVRDITEDKLREQELAFAARHDALTGLWNRAAFDRLLADHIAK--G--VPLAVFYVDLDYFKALNDFAGHAAGDLALKSVAAGIGRCL
PPSAHAARLGGDEFALLVPHCDAAQAERLAAAILAAVRADLGLAATARRLAASIGIAIVNDRATTVADALACADDACYAAKAAGRDRFAVFSAEAATG-L
NAARLAADTVDAMEDGRLKLFGQEIHRLGRPENRHVEVLARLVGRGGKLIPPSEFIPAAERFGIAARLDRWIIRTALSRHGA-KSG---AITLGFNLSAQ
TLSDPGLWDFVDSIIEETGAPHSGIGFEITETAAVTNFDAAETFVRKARERRCKVSLDDFGAGMSSFEYLRRFPVDAIKIDGSFIEHMAESRFDREIVSA
ISGIARSVGCTVVAEKIEQAETLGILQTMGVDFGQGFLLHRPEPLEQIVA----------
>tr|X5RV99|X5RV99_9RHIZ Diguanylate phosphodiesterase OS=Mesorhizobium sp. LSJC265A00 GN=X768_21855 PE=4 SV=1
---------------------------------------------------------------------------------FWALALERAHLGVWDWDIL
SGDCFYSPTWSHMLGYEDGEL---------KLTHPDDRQRA---L---------AETELRLKHKDGHWIWVLD--RGGIVETGKPVRLMGVQTDISRQKE
AEAELERVNLALAASGTGIWHHDIDANKSYWDARTREIFGLVADTDVA--ADLWHSYLHPDAAERAHLAPLSTDGVVAAQYRIVRRDGEESLVRFIAAP-
----ETAGQILGTVRDITEDKKRERELAYAAHHDALTGLLNRAAFDRLLAVHIATERA--LPLAVFYVDLDYFKALNDFAGHAAGDLALRGVAAGILGCL
PASARAARLGGDEFALLVPNCQSAKAEALAGAILAAVRADLGLPATSRKLAASIGIAFVEDTTTTVADALACADDACYAAKAAGRNRFAVFSADAASGSL
NAARVAADTVDAMDDGRLKLFGQEIHLLGQPESRHVEVLARLAGRNGKLIPPNEFIPVAERFGIASRLDRWIIRTALSQHGA-RSG---AIMLGFNLSAQ
TLSDPLLWDFVDAVIAETGAPHSGIGFEITETAAVTNFDAAEQFVRKARERQCRVSLDDFGAGMSSFEYLRRFPVDQIKIDGSFIENIAESRFDREIVSA
IAGIAKSLGCAVVAEKIEQQEALDILRGMGVAYGQGFLLHRPEPLEAIVA----------
>tr|X6EMI9|X6EMI9_9RHIZ Diguanylate phosphodiesterase OS=Mesorhizobium sp. LNHC229A00 GN=X741_25845 PE=4 SV=1
---------------------------------------------------------------------------------FWAKALERAHLGVWDWDLS
TGDCFYSATWARMLGYEEGEL---------QLTHPDDRERA---Q---------AETELRLKHKQGHWVWVLD--RGRSEEV--------GXTDISKQKA
AEAALEQVNLALAASGTGIWHYDIATNKSYWDARTREIFGLVAVTDVT--ADLWHSYLHPDAAERAHRVPLESDGVIAAQYRIIKRDGQDSLLRFIAAA-
----GAAGQVLGTVRDITEDKLREQELAFAARHDALTGLWNRAAFDRLLAHHITT--G--VPLAVFYVDLDYFKALNDFAGHAAGDLALKSVAAGIGRCL
PPSAHAARLGGDEFALMVPDCDAVQAEGLAAAILAAVRADLGLAATSRRLAASIGITIVRDRATTVADALACADDACYAAKAAGRDRFALFSTDAVSGSL
NAARLAADTVDAMDDGRLKLFGQQIHLLGRPESRHVEVLARLAGQGGRLIPPGEFIPAAERFGVAARLDRWIIRTALSRHGA-KSG---AITLGFNLSAQ
TLSDPGLWDFVDRVIEETGTPHFGIGFEITETAAVTNFDAAEAFVRKARERRCRVSLDDFGAGMSSFEYLRRFPVDAIKIDGSFIEHVTESRFDREIVLA
ITSIARSLGCTVVGEKIERQDTVAMLGDMGVEFGQGFLLHRPEPLERVVA----------
>tr|G4QF07|G4QF07_GLANF Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Glaciecola nitratireducens (strain JCM 12485 / KCTC 122
---------------------------------------------------------------------------------YWQLVRDD-NGNIKTWRLR
A----INPAAQKSWGMTLEEVIGKT---TEEIFSPNSRDLF---M---------PGVPHTWFPDKDQYLKMTS--VP---L-GDHF--ISTGVDITDLVK
ARKEAEEKEFVLDVSELGYWDHDIQTNQTSRSLKHDQQFGYAEMLPWH--HETLLNHIVKERVDRVYKKSVLSGGDYDVEFRCKWPDKKIHWLWCKGRFI
TNAKGDVIRSVGIQADITAKKYAGAKIEKLAFYDPLTKLPNRRLITERLKHALTNRKRSRDYGALLFVDLDHFKDLNDSLGHSIGDLLLQQVADRLRNCL
RGVDSVGRLGGDEFLVLIDDLSQEKVTAIANKVLSALNQAYQLDGYEYHNTPSIGVTLFGEHALKLDELLKQADIAMYKAKESGRNTVCFFDYKMQEEVY
YRTKMDYDLRTAIQRNQFQLYYQVQVDDK-GSPLGAEALIRWLHPSRDLVSPGDFIPIAEESDLILSIGLWVLDAACAQLKRWLKS---ALTLSVNISAK
QFHQPHFVEQVLTAIKRHNINPNRLRLELTESMLVKDIDSIIASMTKLASIGIRFELDDFGTGYSSLQLLKKLPIDRLKIDQSFVRDIVHDSSDQAIVRT
VIAMAESLGLGVIAEGVETKEQWLRLQKKGCKRYQGYLFSKPIPIEEFED----------
>tr|K9TLC3|K9TLC3_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Oscillatoria acuminata PCC 6304 GN=Oscil6304_4138 PE=4 SV=1
----------------------------------------------------------------------KRERALCESEERYALAVAGANDGLWDWNLI
TNRVYFSPRWKSLLGYQVENGESRPEEWF-SRVHPDDIDPLKQAIADHL-AGPHFTSEHRILDVQGQYRWMLSRGLAVRDREGNPYRMAGSQTDISDRKA
TEEANIRLAAFPKYNPNPVLACDFQGEIVYVNPATERVL---EELCLGLATGFLPM-NHRELV----VNSLNGKSGWQVERFV--QDRLFYWLYHPIPS-
----LNIVHI--HVMDITDRQNAQDTLRHEALHDSLTGLPNRALFLNRLTSALTRAKIQRYQFAVIFLDLDRFKVVNDSLGHFIGDCLLVALAKRLQNCV
GSGDILARFGGDEFTILVEHIPNQSAIKVAKKIQTELISPFNLKGYEVFTSASMGIAPSTLSYEHPEDLLRDADIAMYRAKARGKARYEVFDKKMLENAV
AQLTLENDLRRSLERSEFLLHYQPIVALDTGLLSGFEALVRWQHPERGLVFPGEFIPVAEETGLILSLGEWVLREACLQMQQWHEQFKTPLSISVNLSGQ
QLGQPDLLERIDRILAETHLNPSSLKLEITESVLMENAALAAELLEKLRSRNIHLCIDDFGTGYSSLSHLAQFPINTLKIDKSFVMGMDGDNESSEIVRA
IATLAHNLGMYVTAEGVEKEQHLVQLWSLHCDYGQGYFFSRGLDRVAAQKLLE-------
>tr|F9U7R9|F9U7R9_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_1145 PE=4 SV=1
---------------------------------------------------------------------------------RIEKIAAHVPGMIYQFQQD
GVFPYASIGIRDIYGVEPDEAAADA-TPVFDVLHPDDRPRVEAKVAESMRELTTWRDSYRITRPDGRLIWVEGEASPEPQPDGSVL-WHGSIRDVTDRKQ
AEEKLRLAASVFQHSFEAILITDAENRIVDTNPAFSAITGYEQSSVLGQDPKILASGRHDEAFFRQMWDAITQKGSWQGEIWNRRKDGELYAELLSISAV
RRADRSVANYIGMFSDISELKAHEAELDRIANYDQLTGLPNRRLLFDRIEQASARAQRSGRLMAVCYLDLDDFKPINDQYGHGVGDQVLIGIAGQLRKVL
RAQDTVARLGGDEFVMLLNDLTREDMLVLLERVLAACGRPIVLDGVTHRVSASIGVTLSPPDGDSADILLRHADQAMYRAKEAGRNRYHLYDAKQDRQLQ
DRRLKLQRIKEALAGDELVLFYQPKVDMVSREVIGVEALIRWRHPQEGLLLPGAFLPVIEGSDLEIAIGEWVIAAALNQVAIWKRGGLD-LPISVNISAG
HLSAPSFARRLGELLAAHECDPGCLEMEILETSALSDIVQAGQTLKTCRALGVRFALDDFGTGYSSLAYFRRLPIDVLKVDQSFVRDMLDDPEDMDIVES
VVRLARAFKRVVIAEGVETPEHGALLILLGCPLGQGFGIARPMPADAVPAWVS-------
>tr|A0A063BN22|A0A063BN22_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Burkholderia sp. lig30 GN=LIG30_1398 PE=4 SV=1
---------------------------------------------------------------------TMATAELFKSKQTLEYVLDHIPQGIAWKDAD
HRYAGGNEIYARDAGLPSRSLIGLT-DWA--LHWGDDPQELD--EDARVMRGTKKHFERAAVAVDGSEVWLSETKLPLKDQSGAVTGVLIAYENITARRD
AELALRLQARAIDASINGIIIAERQHVVTFANQAFERITGYSPSDVAGADCNTLFGGAGEAQTWEHVRQAMDSNTEANVTLFCTRKSGERFWVNVLGAPV
RDESGAVTHHVCVMSDVTALVEYQTRLQHQARYDALTDLPNRTHLDERLTEMIRRAAGSDGQVSVLFLDLDRFKEVNDSLGHRVGDALLVCVAKRLQRLV
RAGDLVARYGGDEFLIVVEPLTDGQLIPMLDRLIAEMAEPFHVEEQELYIEASIGISTYPHDGEDADTLIRNADAAMYLAKANGRNGYQFYRPELHRAAA
EKLQLSTRLRQTVKAQGLRVAYQPQIDMMTGRVVGVEALLRWHDAELGNVSPAVFIPVAEETGMIRDIGEWVLRTACLQAGQWRDAGQAPIRVSVNVSPL
QLEHSDLLNIVRSALDDAGWPADMLELEVTEGALMRNAEAVARVLRDLRELGVKIAIDDFGTGYSSLSYLKRFSIDRVKIDRAFVQEIGRDTGYEALTVA
VIAIANALKFDVVAEGVELDIHRRFLIEHGCVEGQGFLYSAAVSEDAIANMLRPM-----
>tr|K8RBL1|K8RBL1_9BURK PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Burkholderia sp. SJ98 GN=BURK_019650 PE=4 SV=1
---------------------------------------------------------------------DLAKNELYQSKQTLEFVLDHVPQGIAWKDVG
HRYVGGNQIFAADAGLPDKQLVGLT-DFD--LRWGDDPSAQE--EDRRVMAGSCAYVERRAFGADGQEVWISETKVPLEDQSGEIVGVLRAYEHITQRRK
VEIALRLQGRALEASINGIIISEVRHIVIFANQAFEQMTGYSENDVLDADCEQLFALDGQPDNWEVVRNALATKSEANTTLRSKRKDGQLYWNHVFVAPV
RDENNCVTHHVGVMTDVTALVDYRERLEHQAKYDSLTGLPNRTSLDESLESAILRAKTTGKQVWLFFLDLDRFKEVNDSLGHRVGDALLKLVANRLRGLV
RPSDLVARYGGDEFIMVIERSGAHEVVSLLEQIVAAMEEPFDLEERELYVEASIGISSYPKDGLDSDTLLRNADAAMYSAKASGRNGYQFYRPEFNIAAA
ERLRMSTNLRRAVKAQGLRVVYQPQVDMLTGLVIGAEALVRWDDEELGSVSPAVFIPVAEETGLIESIGEWVLRTACYQAKSWLDEGLRAIRISVNVSPR
QLERSNIVDVVRNALHDACLPASSLELEVTEGALMRNVEDVAKTLCELRSLGVRIAIDDFGTGYSSLSYLKKFSVDRIKIDRAFVREVGMDEGSEALALA
VIGIANALKFEVLAEGVEQDVHRSFLVSHGCTAAQGFLFSAPTSPLKVAEMLGGR-----
>tr|G2FEB3|G2FEB3_9GAMM Putative signaling protein OS=endosymbiont of Tevnia jerichonana (vent Tica) GN=TevJSym_ah00620 PE=4 SV=1
----------------------------------------------------------------------SYETALHAEEEYLHQILDHVADGVAVFDVQ
GVPLYLNATAYHLFQSPKPQLSIPEI--KNKVFNAGKRALNSELPQILALNGRVQGLELSLYDLDNQRISLLANSQPLMGNDGHLEAVVVTYHDITANKR
AESELRLAASAFE-VPESMFITNHSGIIQHVNQEFSTMTGYKPDELVGSDSEILASEHHSNDFYVEMMKTLESAGRWEGELWCKRKDQKQQPLWAKITSI
QTEKDKESYYLVSMVDLNTQYRKQNEMIARAYHDETTGLPNRTLLLDRLDQSLARSARSGVLGAVLSVEIDHFVNVNQTLGHLIADRLLKELAERLKRNV
RRDDTLARSGDGQFTLILNEVASQDAIAIAEKFKARISRPFHIFDHEVHVTSSIAISTFDGKNITTESVINQLDTTRKAAKEEGINSIRCFHPEMLSKVK
RQLSIENDMRIALQRDQFSLFFQPKINVKNGQLSGAEALIRWKHPQQGYIDPSYFIPIAEENGLIEQLGEFVLREVCCRISIWQQSGLQVIPISINISAV
QIRHDKFINSVNSILKETGVNPRYLEFEITESALEQNFLQIKRTIHSLKDQGIIISIDDFGTGYSNLSYLNEIVIDRLKIDQSFIYKLTEQKCKSPVAET
IISLAHNFGMTTVGEGVETKAQFDFLRELGCDEAQGYFFCKPVSINIFSDLLKNP-----
>tr|Q935Y8|Q935Y8_SYNE7 Uncharacterized protein OS=Synechococcus elongatus (strain PCC 7942) GN=SEA0008 PE=4 SV=1
-----------------------------------------------------------------------VISQARNSQTYLRQILDHLPIGVAVHELT
GRMTYVNAVGREILRYKSATLEEMAK--FFNIYQAKNRLTIEELPLAMALQGLSHTEDLELRWP-DRTIPLEVWGIPIHDETGHIKEGMTVFQDIHERLE
NA-----------------------RLIQQANEQLSLT-----------------------------VQELEAANH-KLEQEASERQQAQAQLWHL----
------------------------------AHFDTLTQLPNRAYFVEQLHAWFNRYKDHQYPFAVLFLDCDRFKIVNDSLGHSAGDVLLTQVAQRLQSCI
ASPVIFARLGGDEFGVLVPAQDP--PQDLAEQLHELIVHPFEIQGQRIYIGVSIGISFVSAQIDAAEELLRSADTAMYAAKRNLSRGIQIFSAKLSANSL
KNLALETALREAIKQADIDLFYQPIVDLETGALVGAEALARWFHPELGNIPPLEFVTLAERSKLIFSLGNFILEKACLQIHLWQQDHLITFILHVNISAQ
QICHEDFEDWIKDILQRTEISAQNLMLEITESSVAEDIDQLLKLLDELKSMGVQLSIDDFGTGYSSLSYLQRLPVNSLKIDRSFIHQINLAGDNRQVAQA
TIALAHSFGLEVVAEGIEEESQLYWLRQLGCDMGQGYYFSKPLSAADMTEFLRCH-----
>tr|M9YJP3|M9YJP3_AZOVI Cyclic di-GMP signal transduction protein OS=Azotobacter vinelandii CA6 GN=AvCA6_26340 PE=4 SV=1
--------------------------------------------------------------------------------ALKGALFDFSSAAIFSLDRQ
LKVIEWNAAAERLFGQERDGVLGRAA--GEVVTAPNGPADWAAILGSGFFLGGPFDAELRFVTFTQEEREIH----------------TFVLNDISERKH
TERQLRQERAVLNSLPGVFYHYDENVRLRRWNRNLERITGYKSEELAGVEPTIFFADEDKALVASRIGEVF-EKGESSVEADYLLKDGQRIPYLFT--GV
RFEYDGRRGFVGVGYDISERKRAEQRIRHLAMHDGLTDLPNRNLIQERIEQAIVRARRGGRLLALLYLDLDRFKVLNDGYGHLFGDAVLKTASERLLKLV
REGDTVARLGGDEFLILLADLEQADADAVARKIVGSLDCPIVVQERKIHLSGSIGVSLFPRDGETADELIDNADMAMYRAKELGRNTYQFFTRAMSLETQ
RRVDLEIKLRGAATAGQLQLVYQPKVSLENGGISGCEALLRWHHPELGIVSPEHFIPIAEDSGLIVPIGDWVLRTACMQARAWMDAGLPPVCVAVNVSTR
QFLQQDVVAWVTRTLRETGLPAARLELELTESLIARDIEKVTATIDQLKDIGVKLSIDDFGTGYSSLNYLKRFRVDTLKIDQSFVRNMLTEMEDETIVLA
VIALAHNLKFKVIAEGVETEQHSRFLCSNGCDEIQGHYFSEPVTAEAFETMLRA------
>tr|N6Z805|N6Z805_9RHOO Cyclic di-GMP signal transduction protein OS=Thauera linaloolentis 47Lol = DSM 12138 GN=C666_01025 PE=4 SV=1
--------------------------------------------------------------------------------ALKGAIFDSTDVAVISLDQD
LVVIEWNAAAERLFGLDREQVLEQPA--RQAIAAPDGPAHWDEMLATGFLAGHAFDAELRALTVNQHGRPIH----------------TLFINDISARRI
AERRLQQERAVLNSLPGVFYHYDENVRLVRWNRNLERIAGYTAQELAGADPMMFYADEEKARVASGIREVF-EKGECAVEADYLLKDGRRIPYLFT--GV
RFEYGGQRGFVGVGYDIAERKRAEARIRRLAMHDDLTGLPNRNLIQDRIAQAISHARRSGSLLAVLYLDLDRFKVVNDGYGHLFGDAVLKAAGERLQQLV
RESDTVGRLGGDEFLILLADLRQTDAEAIARKIIDGLDRPIIVQGRNIHLSGSIGVSVFPCDGETAEALIEHADMAMYRAKELGRNTCQFFTHEMSKETQ
RRVDLETRLRNAAAAEQLRLVYQPKVNLQDGRITGCEALLRWQHPELGAVSPGHFIPIAEDSGLIVPIGDWVLRTACAQARAWLDAGLPPSSVAVNISVR
QFLQQDVVAWVKRTLQETGLPPAWLELEITESLIAQDIENVTDTIDRLKDIGVKLSIDDFGTGYSSLNYLKRFRVDTLKIDQSFVHNMLTQTEDETIVRA
VIALAHNLKFKVIAEGVETSEHCHLLREHGCDEIQGYYFSMPLSAEEFAALLRS------
>tr|S6AK35|S6AK35_9PROT Uncharacterized protein OS=Sulfuricella denitrificans skB26 GN=SCD_n01125 PE=4 SV=1
---------------------------------------------------------------------------LDQSENRFRAIFDQTFQFAGLLDRE
GILLEANQGVLDAAGIRASEVVGRP-LWDTPWWDPAEAPRLREAV-ERAAHGEFVRYETYFLGSDGMPRAVDFSLKPFREKNKEITWLIAEGRDITSLKQ
AEAELRAEKVTLSSIGDAVITTDAMGRVEYLNPVAEQLTGWASWEAHGLELKVVVGETPTHAARM----------LVPGELELRTRGGREVSIEESVAPI
RDGNGDVLGCVLVFHDVSEKRRLMQQITWQAGHDALTKLPNRSLLADRLELAISSAKRMDKLLMVGFIDLDKFKEINDLYGHELGDLLLIEVAHRLTLSV
RGGDTVSRLGGDEFVLLLTNVADEEAEAALQRILLDIARPYQVNGLIMQLTASIGATIYPLNDTDSGNLLRHADQALYQAKQTGRNRFCLFDISLDKEVR
FLYQEQERIAQALAQGEMELYYQPKVNMRTGEVFGFEALLRWNHPERGLVMPMEYLPLIEQTDLIKDIGMWVMRDVLRQLAVWRAEGLNTL-VSINLGAC
HFRSMEFVDQLRDVLAEYSVPPSSLELEILECAALDDIQTVRSIMLGCQELGVSFALDDFGAGYSSLAYLKRLPANMLKIDRSFIHNMLEDSGDLTIIEG
VVSMASIFNLDVIAEGVETMEQGVMLMRLGCGKAQGYGIAHPMPASKVPYWIEQFK----
>tr|A0A098UJI3|A0A098UJI3_9BURK Uncharacterized protein OS=Massilia sp. JS1662 GN=IA69_02675 PE=4 SV=1
------------------------------------------------------------------------------FGQRIDSLMNSLMQHKSAMDQA
AIVCEVNDLFVTSSGFTRPEVVGQR-LGGARLWQPSDRVWNGEVV-IAGRHGR--------------RHWHR-TIVPMFAAHGTVERYICIDIDITERKE
FERTIVE-NTLIAELGRKALVRAGAGRLA-------------QS--TGLQ---LACPPDD-AAGR----------AWFAALH-GLDTGIDTAIVCGARPR
ADDANFLHGVANIVATAVERQEARNRLTYLAQYDPLTSLPNRRRLAHSLEDAIGT----AARAAVMFIDLDRFKNVNDMLGHGVGDQLLVQAAKRLSACA
RAGDVVARLGGDEFALVLPALE-DGAAAVAARVIEALAQPFYLAGQQLFVSASVGIATYPENGRDAETLLKNADTAMYGAKNGGRNNYQFYVAEMHENAT
QRLQTETQLRQALERGEFLLHYQPKLDLATGTISGFEALLRWHHPQRGLVPPLEFIDILEDTGLILPVGEWVIGDVCRQLKAWQAQGLAVPPVAINLSAR
QLQQADLAGAVERIVARAGVDPALLEFELTESMLMADPEGAVEILARIKALGMRLSVDDFGTGYSSLAYLKRFPLDALKIDRTFVRDLPDDPDDAAITKA
VIRLAHSLSLKVVAEGVENADQLRELEQYGCDQIQGYYVSRPLPAEACEALLAGTA----
>tr|F3FLM4|F3FLM4_PSESX PAS:GGDEF protein OS=Pseudomonas syringae pv. japonica str. M301072 GN=PSYJA_19861 PE=4 SV=1
------------------------------------------------------------------------------FGLRIESLMNTLVQHKNALDEV
SIVCEVNERFVTSSQHSRAELLELT-IWNESWWAPENEVWNGEVR-LAGRTGK--------------VAWHRRTVIPILDDLGGVEKYICIDIDITDRKE
FEVAILD-NNLIALFGQQAIVTAEVGFAGVEIRSNDFLNSTASS--AGFV---INS-----SRYT----------LLPCEAC-SIRSGLEVDISCRSRDY
REDVSYLQTLANLLAAALERYDAKNKLTYLAENDSLTRLPNRWFLSNYLREIISRTTSAPDAVSVIFIDLDRFKAVNDTMGHSVGDQLLIQAGRRLRDCI
DENSVVARLGGDEFSIVVTHSVYESLIKLATQVVDALGKPFNLGGQDIFVSASVGIANYPFDGRDTGVILKNADTAMYHAKKSGRNNFKFYDARMNESLT
RRLQTETLLRGALERDEFILHFQPKVSLVDGRISGLEALLRWNHPEQGMISPADFIPILEDTGLIIPVGVWVIRKVCETLKSWEKNNIRLVPIAINLSVR
QLQVKGLAETVKHIVEAYGISPALLEFELTESMLMIDPESAVEILRDIKSYGISLSVDDFGTGYSSLAYLKRFPLDALKIDRAFIKDITSNHEDAAITRA
VIVLAHELGLNVIAEGVETVDQLELLVTYGCDQMQGYLFSKPVISEECAAMIKSSH----
>tr|F3ES03|F3ES03_PSEA0 Sensory box protein OS=Pseudomonas amygdali pv. mori str. 301020 GN=PSYMO_04218 PE=4 SV=1
------------------------------------------------------------------------------FGLRIDSLMNTLVQHKNALDEV
SIVCEVNERFVKSSQHSRAELLELK-IWSEPWWVPENEVWNGEVR-LSGRTGK--------------DAWHRRTIIPILDDMGGVEKYICIDIDITVRKE
FEVAILD-NNLIALFGQQAILNAEVGLNHVEVRSNDFLNGTASS--TGCV---IDS-----NRYT----------LLPGEAC-GIRSGLEIEISCRSTDY
REDVSYLQTLANLLAAALERYDAKKKLIYLAENDSLTHLPNRWFLSNYLREIISRKTSVPDAVSVIFIDLDRFKAVNDTMGHSVGDQLLIQAGRRLKDCI
DENSVVERLGGDEFSIVVTHHVYESLIKLANHVVEALGKPFNLGGQDVFVSASVGIANYPFDGRDTGVILKNADTAMYHAKKSGRNNYKFYNATMNESLV
RRLQTETLLRGALDRDEYILHFQPKVSLTDGRISGLEALLRWNHPEHGMVSPAEFIPILEDTGLIIPVGEWVIRNVCETIKSWEENNVRQVPIAINLSVR
QLQVKGLAETIKHIVEGYGINPALLEFELTESMLMIDPESAVNILRDIKSYGISLSVDDFGTGYSSLAYLKRFPLDALKIDRAFIKDITSNHEDAAITRA
VIVLAHELGLKVIAEGVETVDQLALLVTYGCDQMQGYLFSKPVIIEECASMIKSSR----
>tr|Q31MH3|Q31MH3_SYNE7 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Synechococcus elongatus (strain PCC 7942) GN=Synpcc7942_1716 PE=4 SV=1
-------------------------------------------------------ISLYFRDISD---RVMSRQLLEEMAERFQLVTRATNDAVWDRNLL
TNEIWYSANYSRLFGGEEKEITQKLVQWR-DRLDPDQRERIMASLSGAIANGSTWSEQYRFLRQDGTYAHVLDRGYIVRDENGRAIRAVGAMQDISAIVA
ANEQLRLWLRAIESTGNSIIIADADMPIIYVNPAFEKITGFSAAEVIGRNFRFLQGLETQQAELEEMRRALEEGTYCEVTLRSYRKDGSLFWNQISLAPV
RDQKGHLTHMVASQTDVSESKAFEEMLLQQATHDALTGLPNRLLFLDRLDQAAARARGGGSPIAVLFIDLDNFKAINDGFSHSEGDAVLQIAAGRLQQCI
QEHETVARLSSDEFVILLIDLDVSKARVKAAMIQSLMAKPFEVMGNPIELTASIGVATFPHDGQSGSELLQAADLAVCAAKQQGKNLWCSFSEAMREQLR
SRIDIEKDLRQALIDNSLELYFQPQVDLVTHRLLGFETLVRWNHPERGLVAPGEFIPIAEESDLIDAIGLWVMRAAGLTLRRWIDHGFT-GSLSFNISAR
QFIRQNIFLKLFDVLQEFQIPPHQLEIELTESSLIESPERFVQWLQEARSMGFQVALDDFGTGYSSLGYLKRLPINALKIDRSFIRDLPHDHDDQAIVQA
IVAMAKVLKLRTIAEGVERLEQAAFLEAIGCDAVQGFFYGPPLPEAEALAFLHRSASP--
>tr|A0A066ZR34|A0A066ZR34_HYDMR Uncharacterized protein (Fragment) OS=Hydrogenovibrio marinus GN=EI16_08190 PE=4 SV=1
------------------------------------------------------------------------EKEIENSLRAERNLFAGGPAIQWEPTEN
WPIVYVSKNIENVLGYTTEEMMSKD---FSSLIHPSDYERIKSALNENL-FGSCFELSYRLKTKAGVYRNFYDYNQAEYHRNGDVKSLYGYLVDMTSYFE
VEQMSS---LLLNNTNEGIFGLDLEGNTTFANPAALNMLGYQEAELIGHQNHIHHSHPDGHVERCRMSMPISTHEDYHVDEVLWRKDGTSFPVEYWSKPI
RQ-DDQIVGAMVTFRDISEDIQQEQKISHLSFYDNLTGLPNRRMFLDKLKEELVAERDSSHRAVLLLLDIDHFKEVNDSLGHTSGDKLLVDLVSRIQRKL
RDRDVLARMGGDEFSILLSPDERVDAGHFSDEILRIFDTPFDIDGHEIQTSASIGIVFCD-PSKSRNSVISEADIALYQAKNFGRGRAVFFEPSMSSKVH
QDMALFNALNHALQNDGFELHYQLQFDPQTEKVVGAEALIRWPNAPEEVSSPASFIPVVENRNLIQAMCLWEIDRLATDLPVLRKAGFN-CRVSINLSGK
QLMNSDNLGQLLKAIQDSDLAFQDLEFEITETAYAELSEDVQKLMDVFMRNGVDIAIDDFGTGYSSLAVLRQFKSTHLKIDKQFIDHMHSNSDDYAIVSA
TISMAQALGKKVVAEGVESEIQVQMLKELGCDIIQGFYYARPQSLEKVCQQLKSTS----
>tr|E3HCL3|E3HCL3_ILYPC Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Ilyobacter polytropus (st
------------------------------------------------------------------------DFILQSSVKTALNLFEKSRNLYWEFDLD
NNTVKSSKGSRKIYGITEETLMVDN---IK-YPLPEYRERLDKAFKDLI-TGKNYNVEFKIKNKIGEIRAIHSVAEYDPKRNIVIGTLYDITRQEESAFK
KEEEYR---KIFQNHNAVMLMIDVTGEIVDANNAAVKFYGWTRKELTKMKIANILTE---N--YKEMEMARRNKKNYFTRH--RLADGSIRDVEAYSGEI
IS-GK-RPRLFSIIHDITKRREAEKKIKNLAFYDSLTNLPNRRMFSDYLEKSIVQGQRNDFQVALLNIDLDHFKHVNDSFGHHIGDLLLIRVAERLRRNL
RKNNIICRLGGDEFAVIIEEFSSQEINFVSGRILKVLEAPFLIDDKEIFISASIGVAVYPEDGSDVNTLLKNSDLAMYGAKDRGKNGYYFFSEDMKHASN
SKMEIDTNLRKSLINGELCLYYQPKIDIAQNKIIGTETLLRWFKNGKIYKAPSEFIPIAESTGFILEIDRWVLLSACRQIEEWEKNNIG-QKISVNISGL
HFKQGLIIKTVTEVLKKVKIPKDSIEIEITEGVFMENMEEAVGILNQLRSMGIGISIDDFGTGYSSLSYIKNLPINRIKIDKSFIFNMIDSKKDTAIAKT
VITMAKLLDLYVIAEGVETSEQLKILSENGCNEIQGFYFSKPLSPEEYEKFFKKWA----
>tr|L9PCX3|L9PCX3_9BURK Diguanylate cyclase/phosphodiesterase containing PAS/PAC sensor OS=Janthinobacterium sp. HH01 GN=Jab_2c15230 PE=4 SV=1
---------------------------------------------------------------------LRMEAALYASRELKQLVINHIPHQIFWKDLH
GKYGGCNAVFAAAAGLAAEEVVGKTDPWRAEAIRADDRD--------IVATGARLNVEDHLEQRDGRVLWYLINKLPFHDQRGNIIGVLGTIEDITARKQ
AEQTLQLRQRALEASDNAVVITVHGELIDYANPAFTRLFGYTEAEAAGRSLDMLLSGERD-----ALRAALSGAHELTMTLRIVHRDGQLLWARLHVAPV
PAVQGPPSHHVCVLTDMTESINYQVQLEHQANHDPLTGLPNRALFGDRMAQAIGYAERYGHHLWVVFIDLDNFKLVNDSLGHQAGDELLCTVGVRLRACL
DDSDTVARLGGDEFLLLLSDSPESPASALLQQVQDTIAAPMTLAGQMLTVTCSIGVSVYPLDGGEPHQLLKHADIAMYRAKEAGRNQLQFYEAAMHSRIS
ERAMIEAELRHALARDELRLHYQPKLDLRTGAVVGMEALVRWQHPAMGMVSPARFIGVAEETGLIVEIGRWVLRSACFQNAAWQQAGLTPLRVAVNVSAR
QFRDPGLSREVQAALSDSGLDARYLELELTESLVMHNVEGAVAVVTGLKQMGIALSIDDFGTGYSSLAYLKLFPVDYLKIDQSFVREMLAEPKVAAIVRS
VIALGQSLGFRVIAEGVETAPQLAYLRHHLCDEMQGYLFSKPLPPDDFGALLRCLALPSD
>tr|C5USQ5|C5USQ5_CLOBO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Clostridium botulinum E1 str. 'BoNT E Beluga' GN=CLO_1504 PE=4 SV=
------------------------------------------------------------------------------KNIEIEHITNSVDVGVATISCF
LSVNYANDGFYKLIGYTCKELKNLLNNQVIKIINTDDLVKLREQLLVDT-TNTYTKSEIRLKKKNGEIIWILLSGHKFT-TNNNLIEFLCVIVDITEFKQ
MQHALELEKIIAEQSNNILFDYDISCKMVYSIE-FTNLTGKTIPNFVHSTINNNLIYKEDLPKFLNLIKSLSSGKDFTADLRINDINNSYRWFKVQATIL
FED-KKPIKAIGNIVDIDKEKRENETLKLKAQLDPLTKVYNKMVTKSLIENYLTTVAK-EKYHALMIIDIDNFKSVNDNLGHMFGDSVLSEVSSNIKKVF
KESDIVGRIGGDEFIIFIKNISSEVISQKANDLCTIFKSIYTGENNDFKISCSIGIAIYPTHGTTYNELFKKADKALYSSKNNGKNKFELFNPKLDFFNK
NHIEIENLMFSSLENNEFLVYLQPKIDLPTQTIVGAEALVRWMSPSKKLIPPNEFIPLFEKNGFIIELDFYVYEEVFKKMNSWIQEGKKVIPISLNVSRS
HINDSDFIPRLKKLTEKYNVPTNLIELELTESIFFDNIQVLLNAIIELKALGFTCSIDDFGSGYSSLNLLKDLPIDVLKLDKEFFPNSSINSKEKVIISN
IVKMAQDLNIIVISEGIETKEQADFLTEIGCDMAQGYLFDKPMPIKMFEKRL--------
>tr|A0A0A7FR02|A0A0A7FR02_CLOBO Diguanylate cyclase domain protein OS=Clostridium botulinum 202F GN=U728_1151 PE=4 SV=1
------------------------------------------------------------------------------KTIKLEHITNSIDGGVATISCF
LSINYANDGFYKLIGYTREEFKNLMNNQVIKIINNKDLTKVREQLLLNT-SNNGIKAEIKLKKKSGEIIWILLSGHKFI-TDNNLPEFLCIIVDITESKQ
IHHALELERIIAEQSNNILFDYDIPCKMVYSMK-FTNITGKNIPNFVHETINSNLIYKKDLPKFLNLIKSLSSGKDFTTDLRINGLNNSYIWFKIQATVL
FED-KTPIKAIGNIINIDKEKRENEALKLKARLDPLTKVYNKVVTKSLIENYITTIAK-EKYHALMIIDIDNFKSVNDNLGHMFGDSVLSEVSSSIKKVF
KESDIVGRIGGDEFIIFIKNISSEVISQKANDLCTVFKSIYTGENNDFKISCSIGISIYPTHGITYDELFKKADKALYSSKSNGKNKFELYNPKLNSFNK
NHTEIENLMFSSLENNEFLVYLQPKIDLPTQTIVGAEALVRWMSPSKKLIPPNEFIPLFEKNGFIIELDFYVYEEIFKKMNSWIQEGKKVIPISLNVSRS
HINDSDFIPRLKKLTEKYDVPTNLIELELTESIFFDDIQVLLNAIIKLKALGFTCSIDDFGSGYSSLNLLKDLPIDVLKLDKEFFPNSSINSKEKVIISN
IVKMAQDLNIIVISEGIETKEQADFLTEIGCDMAQGYLFDKPMPIKMFEKKL--------
>tr|E6U460|E6U460_ETHHY Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Ethanoligenens harbinense (strain DSM 18485 / JCM 12961 / CGMCC
-------------------------------------------------------------------------------HSQFRVLVDRIHCGIAIIRMG
FSLLRANPAFFRISGYTPDEFLEKFDNKAIYMLCMEDHAAVYEEIKKMDTQRVHVHVDFRIQSKDGRIKWIHMDSFLFH-AEGREPVFQCIFTDITALRS
SVEQAEMEAIIAQLSDDILFDYDIAKTMTATQP-ISDLYAGSISDFYNDIVENLVVHKDDVDALADFAGEPGGIQEKRTELRIRSANNGFAWYRMEGAVL
RDKYAKPLKIVGKFTNIDRQKREKEYLTQKLQRDPMTGVFNKVVTEKLIDRYLHKADE-DDVSALFVMDLDNFKNINDALGHLSGDRVLTHVAEGIKQIL
RSSDIFGRIGGDEFVVFIKNIRSTFAAQKARQLCQIFRSPVLEQELRYAVSGSVGIAMSPTDGKSYHELFEKADRALYVAKGQGKDGFAFYQNNLPGEHG
A--DMESHMVSSLEKNEFVIYLQPKYGLVDRKIAGAEALVRWNHPTRGFLGPNDFIPLFEKNHFILELDFFVFESVCRMLRRWMDEGRPVVPVAVNFSRV
HLLTNDFVEQLIALVDKYQIPPHYLEIELTESAYISRFHNALQIAQRLRQHGFLMAMDDFGAGYSSLNSLKSLPLDILKLDKNFFQEKEPTPKETIIIEN
IVRLAKQLNLCVVSEGVELEWQAEFLCSVDCDLVQGYLFSRPIPVTTFEKIL--------
>tr|R5YMK3|R5YMK3_9FIRM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Roseburia sp. CAG:197 GN=BN528_00387 PE=4 SV=1
-------------------------------------------------------------------------------MNYKELMAADIPIASAIISYD
WKIERVNTEFVKLSGYTERDLGE---SGRDQLITEKDSYLFEETLAQAIATKMPADQVLRIRRKDQEIRWVAFRSSVFH-YIDAVPYLLVVFWDIDHQKR
KEISQEILKMMERLSHEYPFDLDVKWTMMRSHR-LMELYGT-EDVYYPVDEEVRSLSPVDHKPFLDAMHEAAMVVKSSARFNISGEAPRYQWFRTYYRSV
TNAEGEIIRIIGRSFNIDMDKSLQ----EEVRRDPLTQLLNKLEVQKEVTRYIEENP--NKCSVLFLIDIDNFKGINDNFGHTFGDTVIMDMAKQIQSQF
RMNDIVGRVGGDEFLVFMKNTTV-KAEEKAKLLCHSLEKKYMGQKLHYRLSASIGMAVYAKDGDNYRTLFEKADHAMYRAKQAGKDGYQLAQEEDCGPVK
NRQKIVGEFFEALYRDDFRMYLQPKFILGERHVYGAEALARWRRPDGTILPPAYFMDPLEKIGYITELDFYIFEEVLKTLDKWERQKRRKLVISTNFSGR
HFDTEEFLNRIQHIFSKYTVPAEYVEIEVTEGVLVKNVHVLERCVNRLHEMGFRVSIDDFGTGYSSLSVLADMPADVVKIDKSFINKDMNGKK-MDILYE
IGRMVKILQKDIIIEGVETEEQEKLLINGGFTCGQGYLCNKPIPIGEFEKLY--------
>tr|R5VBN2|R5VBN2_9FIRM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Roseburia sp. CAG:18 GN=BN518_01714 PE=4 SV=1
-------------------------------------------------------------------------------MDYREFIQLDLPVAVAIVSCD
WRVEEANAEFTDVLGYTEKELRE---TRPQKMVYDEDYANLVSVLENVVRTHDNGKMQLRIVRPDGKTRWVEMRCSVLA-HYDVKPYVVLFLWDIDEEKR
REEHQKLLNLMEQLSLEYPFDLDVEWTMLRSYR-LMELYDY-SEQYFPVDEEVLTLCPPDQELFLKAMKEAATEEKTSTRFNIHNETPKYLWFRTYYKSI
ADHNGRITRIIGRSFNIDEDKNLQ----EEVRRDPLTKLLNKLEIQRETDAFLEGAE--DGTHVLFLIDIDNFKGVNDNFGHTFGDTVIVDVANIIKSFF
RNNDLTGRVGGDEFLVLMKNTTL-KAKERAGNLGEALCKVYTGGSIHYRISASIGLAACGGDGNTYSSLFEKADHAMYRTKQGGKNGYEIAGAKDVGMIR
NRQKIVGEFYEALYRDDFQMYLQPKFILRDRSVYGAEALARWKRPDGKILPPGMFIDSLEKIGYITELDFYIYEEVLKTLEKWDKQHRRKIVISTNFSGR
HFESEEFLNRIQHVLSKYSVRPEYIEIEVTEGVLVKNVAVLEKCMNRLHEIGFRVAIDDFGTGYSSLSVLADMPADVIKIDKSFINKGMTEQK-KNLLYE
IGRMVKILHKDIIIEGVETEEQEQFLKEGGFTCGQGYLCNCPVPIGDFEKMY--------
>tr|G2T2E1|G2T2E1_ROSHA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Roseburia hominis (strain DSM 16839 / NCIMB 14029 / A2-183) GN=
-------------------------------------------------------------------------------RGQRKDLIGKMPVGIAVVRGE
LYIEMVNREFLHAEGYDRE-ELTGN-TPFVEYLYRDDTGVFEDAIEVCRELRTTEEIELRIRTKSGGVCWELMRCRLYY-YRDAVPYYILASWNIDKRKN
LEEELRLMEMLEEVTDEFPLEYDVARRFRVPRK-YRGNGTA-GRRYMDYEEMLADICEEDRAAYARVLEAASRDVRTSYRMNVAGEEPVYVWYRTIYRSI
VGDNGQIIRIIGRSYDVSSDRRIQEELSEEAKRDPLTRLYNKVAASGEVERILKSEP--EKQHVLFLIDIDNFKRINDTFGHTVGDTVITDIAGVLQSQF
QETDVTARVGGDEFLALMRDVAP-EAEACAAALGREARKKLIGDDAIVEVTLSIGMAVYGEDGRDYETLFAMADRAMYATKREGKDHYSFAGKKQQEGAE
RG-RITGRFYAALQRGEFEVYLQPKFLLREERVYGAEALARWRLESGEILSPARFIPALENIGYIVDLDFYILEQLLRAMRRWRDSGRELFTISTNFSRR
NFENDDFIERLQNTLQRYGIDPCYIEIEVTESVIVEKLDSLKACLTRLGKLGYRIAIDDFGTGYSSLSVLLEIPANVVKIDKSFTDKIHQNGQ-SAFVYQ
MGQFIQSAKEEVIFEGIEEEQQRTFLMECGFNYGQGYYFDRPLPLEEFEKKY--------
>tr|D4KVS2|D4KVS2_9FIRM Draft genome OS=Roseburia intestinalis XB6B4 GN=RO1_07490 PE=4 SV=1
-------------------------------------------------------------------------------KENRKGLIYEFPMGVAVLKGS
LQIDIANAEFMKAIGHGEQAEPDRN-RDFYDCVYLQDAGVFEDMIEKCREQKRAEEIEVRIISGQGQICWVKFWCSIYY-YKDAVPYYLLICKNTNDRKE
LEDELLLLNMLEEVTDDVPFEYDVKKRFRIPHK-YHINQKD-DQDYMEIEKWLAFIHKDEQTLYREVIQNASEREMSSYRMNTAGGIPQYCWYRTVYRSI
RGTNGKILKIIGRSYDISSDRKIQEQLSEEMRRDPLTHLYNKVATGEEAERILKEYP--EGTHVLFLIDIDNFKSINDTFGHTVGDTVISDIASALEEQF
PDHKLVGRVGGDEFLVLMDNTTL-QAEQKAKELCRHGEKKLVGDDAVIHVTMSVGLAVSGQDGNCYTELFDQADRAMYAIKRSGKSNYAFAGKNKTVHMK
RNYQITGRFYGAMQQGELEVYLQPKFNLEERKIYGAEALARWRTKTGEMIMPGRFVPPLENIGYVVDLDFYIYEQLLRAMKRWKKAGKELFTISTNFSRR
NFESKNFAGRLKRMADHYGIDPKYIEVEVTESVVVENVDELKRVLSELEKFGFRIAIDDFGTGYSSLGVLLEIPADVVKIDKSFTDRINLKEQ-RNFVSQ
MGNFIHSAKEEVIFEGIETEEQLQFLRGCGFLYGQGYLFDRPIPLEEFERKY--------
>tr|R5HX86|R5HX86_9FIRM Uncharacterized protein OS=Roseburia inulinivorans CAG:15 GN=BN501_01368 PE=4 SV=1
-------------------------------------------------------------------------------RKDLKNIIYELPVGLITVKGE
LTIDIANHEFCRMSGYELADFSMEK-MSMAQLIHMEDYMMFEDAAEVCRRGKTSDEFEARIVTADQNVIWAMFQFQIYT-YRSAVPYYLVSCWDITERKK
MENEIMLVNMLEEVSDDIVLDYDVKQQFEIPEC-YLKF-DK-SVKYAGIEELYGAIHPDDRERFQKIFETALQREMKTYRLRQGKESGKYAYFRTCYQSI
ADYDGKISHIIGRSYDISTERAVREKLLREVQLDPLTRIYNKTASGEIVDAFLEKST--QGTHVLYVIDIDDFKKINDTFGHTVGDMVISDIATLIREQF
TDEAVVGRVGGDEFMVFVKDTSL-EAEAKAEQLCTNVQKTLSGDGAVIVVTLSVGMAVTGKDGYDYSTLFERADHAMYHIKKNGKNHYGFAGETEEGDCE
GKQLIATRFHAAIQRGEFEMFLQPKFRLKENTIYGAEALARWHFGEDGYLQPNRFVPALELMGYIKDLDFFILEQLLKYMTKWKKSGKSLFTISTNFSRK
HFENEAFLQRMHETMDKYDIDPSYIEVEVTESVMTEKLEDLKHCMIELAQMGFRIAIDDFGTGYSSLSVLYEIPANVVKIDKSFTDKVMVDNK-GEFVSQ
MGKFIRAAKEEIVVEGIETEEQRQFLESHGFEYGQGYLFDRPIPADEFERKY--------
>tr|S2KS11|S2KS11_9FIRM Diguanylate cyclase (GGDEF) domain-containing protein OS=Lachnospiraceae bacterium 3_1_57FAA_CT1 GN=HMPREF0994_07221 PE=4 SV=1
------------------------------------------------------------------------------SNSLIQTLIGRLPVGILYCDFT
LTIEGANEGFFRLTGFMEPDLEERFHNSLSEIIHPDDFTKVAEQVARQFLN-EPVSIECRILCRDGSYKQVEYSGRFIN-DSRSAEKLIGVIVGKAESS-
------------------------------------DGDIAVYNQIAAQVSSHKWIHPEDTQVYAELLEKLRAGSIYNAEFRIFNAE-EYIWCQVHGVAM
CGRQEKPLKALCIIFNIEERKQALDDLKIRAERDALTGLYNRNETEKQIRAYLE-EKP-ENICALFMIDTDNFKQINDTNGHMLGDIVLTEMAYGMKKMM
RESDVVGRIGGDEFLIFMKKITSEAAVQKAADLTEMFRRLFENEKRSIHVTCSIGVALYPDDGRDFRTLYNYADRALYQAKSQGKDGYVVYDTANEETGY
SRL-LLKELTDSIANRQYMIYLQPQLNMKTGKIDRAEVLVRCREKDGTISSPVKFIPFLESEGLISNIDFFVMDEVCKLLTKWKGTRFADIQLSLNFSRI
TMFDNNFFKEFRSVFSKYDLNPQQLELEVTETQETLNKKQMAHLLEELKKHNFNIALDDFGVEYSSYEFLMMADFDILKIDKGIIQKYEEAERGKTLVKH
IVDMGHSIGARCCAEGVETREQFDYMKEIGCDYVQGYIVEKPMAVEQFEQKY--------
>tr|R7GEW3|R7GEW3_9CLOT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Clostridium sp. CAG:307 GN=BN598_00101 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----MNDFLFQCVISQNEEFNNRLKKHLLDM------------------------NDIEIEYRDNAPIFSLTPFVQVN-IHQNCDSYYVVVI-------
----PDFQFRFVPTLKGIFFDYNEEGYIVFYNS-KNNE-LLPLKNVLSLDKNILKIKKKDFSNFVLIMQSALQGKKKDFKSSIEKKDV--------TYIL
ESSYKNQSHTLGYFRNIDSYAKEIEKLTNIANKDALTGVYAKQIIKNRIKELLEAASL-NDKYIIGIIDIDYFKNINDTYGHLFGDEILIAFTKNLSKAI
GKAGMVGRIGGDEFLFVYPVKSTEDIKPICRKIKHIIRQITFQDKSQFTLTSTMGISCYPKDGLNYDDLFVTADKALYRGKLKGRDCYIIYNEANHSSIK
KRVTIEAKMENALKNKEFEVYLQPCYELKTNTISSFEALVRWNTNDG-IMSPDHFIPLFEKNGFIVKMDFYVYEVVCQTLARWKNDGHPLRRISVNVSRC
HINDKDFVIKLNALLNKYNIDKKYFGIEITESLFMENENDVISLVEILSKEGYQIYMDDFGVAYSTLNLLSRVHVDVIKLDRGFIRNDFRNNRETIVIRN
IIQMARELGINVLSEGIETQKQALELKDLNCDYAQGFYYQKPMPISEIEKLY--------
>tr|R6WCT1|R6WCT1_9CLOT Diguanylate cyclase (GGDEF) domain OS=Clostridium sp. CAG:91 GN=BN808_01767 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------MEE-----------------------KCMGLKKEVALQEK-----------------------------QTGDVDR
TTRELHRERAVIRMSGDLIFEYDIVDKMYYAGP-GEGIYSRITEGYTDQLLKEAGN--RTETVEQQLAEALRSGKPDYIELCKTDAEGKPRWVKVIGQTF
YDEKGEPERVLGKVCDIDDQKKKEWELREKSQKDSLTGLLNNSTIKQQIGARLQSLKR-GQTGYLVVQDVDSFKKINDTNGHLFGDAVLCSFADELSNIF
-PEALKGRIGGDEFVFYVEDMDR-HLEEKLKQLNRCMSDRYDDDKTGLHISCSLGAAVTDGTVTDYNLLFQWADAALYQVKSKGKGAYYLLDVKEPGKSY
LRSEIVSGMVAAYNNKEFRAYLQPKVSLHTGKVVGAEALVRWIRADGSMVMPGRFIDVFERNGFVTKVDFAILDQVLEYLQDALAQREEVVPISVNFSRR
HNEYTDFVPNILKRLKDYKVPSELLEVEVTESVFMSDLNKLTNNLETLRDKGVEISVDDFGSGYSSLNLLSKVAVDTVKLDKQFLDDTMNSERALTIIKY
LTKMLKHLGFKVLAEGVETKEQLDMLRLADCDIVQGYFYAKPMPIDDFRKFL--------
>tr|S2YKH8|S2YKH8_9FIRM Diguanylate cyclase (GGDEF) domain-containing protein OS=Coprococcus sp. HPP0048 GN=HMPREF1216_00553 PE=4 SV=1
------------------------------------------------------------------------------LQQELSELTQNIPGGVCKILMD
FTLLYGNDSFYQLYGYTSAEMQTQLGNKLIATILPEDATSIMEIIERTYRQESHFEFEQRIFHKDGSIRYLLTNGAFSH-SRKGVPTLNCVIIDITKRRL
SEQELAINEIAVTQTQSVIFDYHIQKQVVHSKE-TMHLNTISYDQY-LRVEGIKNIHREDYPKFLETFANYANGIQEKLEYRHLTNFGKTCWVETTAHMM
KDPVSGDIRCLLYLHDIDAAKRERLTLENASRLDPLTKLYNKGAAETLIHSQLEASSP-DACHAFIIIDLDHFKKINDLHGHACGDKVLKETAKRIQQHF
RSDDIIGRIGGDEFIAFIKNIPSDFLIQKLEKLRYTV-VPF-----RGILTYSMGICLTSNYGFDFEVLYEKADIALYHSKARGRNCFTFYTSVM-QNG-
-SATILQQTLRDLKEERFLIYLQPKVDLSSRKLIGAEALIRYRHEERGLIAPDFFIPPLEKEHLIRYIDLFVLEQACRLLRRWQQEGRKTFPISINFSRI
TLMEEEILPSLLELVHTYQISPSLIQIEITETIEEKDRDVLLTLSHQLRQAGFTIALDDFGTKYTNLSILTYMDFDVLKLDRSLIQTLCFRASNQTIIKH
VIQMCRELPVEVIAEGIENEEQAALLTSMGCPSAQGYLFGAPMPISEFESRF--------
>tr|B9Y300|B9Y300_9FIRM Diguanylate cyclase (GGDEF) domain protein OS=Holdemania filiformis DSM 12042 GN=HOLDEFILI_00175 PE=4 SV=1
------------------------------------------------------------------------------RSEEMTMLTDNLPGGICLIQLA
QTLLYGNRRFYQLLHTTDEEIRQRYQNELGRMIHPDDQASVLKQIKEAFTGFPGLQYQLRIQTDSG-LLYLLVFASFAL--TGSVQTLNCVVLDITEGKQ
REMDIAMNEKALDQVGCVLFDYYFKNQILGTPQ-ACARSQLPYDQF-QRNVARQQIHPDDRRAFLQTFAAYNQERREPLQYRRLSQKRQMVWVETTAHII
QDPATQHLKVLFFIRDIDKEKKHELILQYQSQRDSLTGLLNKGSTEAQIQSVLE-NDP-QALHALLVLDIDEFKKINDTFGHLYGDQVLSRIARQIREVF
RENDVLGRIGGDEFAILMKNCKTQIVRDKAEQLCQKLTTLF-----ADGVSCSIGVSFFAKDGTYFYQLYQNADIALYQSKRQGKNQVQFYLPSM-WTV-
-PEETYQQVMEALKENRFTVYIQPKADLESGRILGGEALIRYLHPQLGVIPPARFVPVLENEHLIRIIDLFVLDEVCRMQQRRQQQSRDAVVLSLNFSRL
TLLEENMALEVEKILSHYDFDPSLIEIEITETVGEIEKETLRTVIQSLKRLHLRISLDDFGTKYTNLSMLTVADFDVLKLDRSLIQELVASPQNQIIVAS
IISMCRQLGVSVIAEGVETEAQRDMLRQLQCGLGQGYLFGKPMPVGDFRTLF--------
>tr|G5HMD6|G5HMD6_9FIRM Uncharacterized protein OS=[Clostridium] citroniae WAL-17108 GN=HMPREF9469_03748 PE=4 SV=1
------------------------------------------------------------------------------ERQTVYHFASILNSGICILQYT
LTIVSANEACYRVYGYTPKQFAEEKNNSPVSLIHPDDRMGIREKLNQSIAGEHYVSFEMRCFCRDGSMIWVEVKSTLLR--ENDMDILVCLIWDITEKKQ
LEHEISLNVIALSKSHNLIWEYHMDDWACIENT-TDSPYRISYSRF-LDRWSEQNVHPQDRGLFLRELRQYENGRQEVCEYRSLNADEKMVWCNTTIYLI
L--SGGHLSGFVYVRNIEEKKHKELELLRQSRIDPLTGLLNRAACLQEINRMLK-DQA-GALSALLMIDVDNFKAVNDNYGHMYGDKVLAGIAYKLKSIF
EDNAVLGRLGGDEFVAFMPDIPNAAACNKAQIIARELQSAQEQGEDQMGISNSIGIAFCPRHGNKFDELYIKADAALRYAKQAGKSCYSVFGSKT-----
--PESAKKLFSDMEHGYYKIYLQPKLDSATGGLRSVEALARYHDPGQEVKPPGKFVPLLEKVKLIRYLDFYMLEQVLKLLCGWKEKGRPLVPVSVNFSRI
TLLESDLFRILREIKSRYDIPSGLVMIEITESIGDIEHKVIESIGSRLRQAGFKLSLDDFGSNYANMSILSIIHFDEVKLDKSLIDNLAENETNQTVVKC
IVNMCRSLDVECVAEGVETREQLELLKSFGCRTIQGYYFSKPVEAGQFETND--------
>tr|C0C522|C0C522_9FIRM Diguanylate cyclase (GGDEF) domain protein OS=[Clostridium] hylemonae DSM 15053 GN=CLOHYLEM_07190 PE=4 SV=1
------------------------------------------------------------------------------YIEQLKDMVEYFPLACYFLKRE
LTILYGNAAFYSMLQQSRDDVRYKYKNSLSSLLSTEKFFEGREFLHDAVHRKHRFYTRMKLSEADG--------------------IYCCMSLDVSDFVL
DKTKNEDMLILFTQIRQEAFVVDVKQIVYMASQ-KKILVRFTYTQL-YTRFIHKVVHPEDRGGYMELMQSYQNGLTRKYEFRRIIEQNKMMWMEIEILLF
KEPLQNELMALMYLTDIDERKKSSFQLRYESEFDQLTDVYNKKSAESKIIQCLR--EP-AELRAFLILDLDNFKDINDSYGHKAGDDTLILFADHLKAVF
HEHCVVGRFGGDEFLVLMEQITSKEVDDALMDLYQKLQEDK-----RYDIKFSAGITLIK-GSSDYETVFEQADKTLYEVKNSQKGLYQYYNREV-D---
-ELQLLRNLIKQIQRGEYVVYLQPKYHLENHKWIGAEALIRQQHPEFGILPPSEFIPVLESNGIIRYIDLFVLEEVCRLLEKWNR---NDLIISLNFSRV
TLMEDDIINSMKKVLDKYDFSRRCLEIEMTESTVEHCSAMLYKTVQEISDLGLRISLDDFGIRYSNLSVLNDIHFDTLKLDKSLIQTLVSHQRSRIILRN
VIQMCRELDIEMIAEGVETSRQEDILKSLDCPNGQGYLFARPVPVKDFEEDY--------
>tr|G1V520|G1V520_9DELT Uncharacterized protein OS=Bilophila sp. 4_1_30 GN=HMPREF0178_02617 PE=4 SV=1
------------------------------------------------------------------------------KNAELEACHAVVFNGFAKLAAE
YTILEANDQFFCMIGYTREEVRGQFGNRAINFVYAEDLIVGNDEIRNRK-ATGRFSIPFRVRRKDGSDIWVRLDACRAE-ERNGHEVLYCFYTDIDEQQR
---EADYRRMSLVTDGGDERRLAYIEGMLHFLG------YEVFQGLMAGGLEAIV-CSDDVALFRTAWREAVNGCY--QEYRIRKGDGQVIWVLEKGRLV
VDGEGEPVC-ICLLLDITERKMRQDELIRQTRLDPLTGLYNREYAQQFIQTYLDIHRG-GHSSALLVFDLDHFKRVNDRYGHLRGDAVLIAFAKLLQESF
RTRDFVARTGGDEFIAFMQDVPSTEALDVSRRIREAMSATLGNEYADCKLSVSIGVAY-SHEQISYDALFQLADDDMYRMKFRARGGRELDELPVSE---
-R-NIESCMEEALRNREFCLHLQPQVDIQHGALFGAEVLVRWERPGYGMVSPGDFIPLFERNGFIVDLDAFVFEEACAYLASRGSRGLPPLRLSVNVSRL
SIAQGDFLDRYSAIRDKYGIDSGMLELECTETMVIRNFALFRELMAALPSRGFRSAMDDFGTGYSSLNMLKEIALDVLKLDIAFFRDTEGTPRERAVVES
IVQMARALGMSTVAEGVEKQEQVEFLRSIGCSAIQGYIFSRPVPLAHFESVE--------
>tr|I0HSQ5|I0HSQ5_RUBGI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rubrivivax gelatinosus (strain NBRC 100245 / IL144) GN=RGE_2703
------------------------------------------------------------------------AVEARWREQRWEWALDGSHLGVADWHVR
RGEGFASTAWRALAPASEPAW-TP-ATWL-AQVHPDDRAALEAAIA-LIDSGGRQQLELRMRRE-AVWRWRQATLLVIEGADGRPARILATLADVEERHD
ALERQRLSASLFQHLHEGLLVTDAELRVLEANPAYTEILGVAREELIGTVPSLLSPAPDDAQQRAEMWSALRERGSWRGELDERRADGSLRTLQATISTV
PGAERSTHHHVLVISDITEQRRQRELLERQALFDELTRLPNRAQLSSLLAEAMEVADRDGFLVAVCYLDLDHFKPVNDRFGHAAGDRLLVELASRLRTAL
RRRDVAARLHGDEFVLLLRA-GSDEARRAIVRVLRVLSQPYLVDADPVAITTSLGATLYPLDRQDPDTLLRHADHAMYEAKQSGRNGYVLFDPASRLERE
AQVMAQDEIEQALERGELMLRYQPKVDMRSGRVVGFEALLRWEHPTKGELPPHAFLPRIEDDGLLVRVGDWVLSQALEHLAQWRRDGLD-FAVGVNVSSR
HLRRADFAAQLAALIARHGHDAPYLELEVVETAAIAASPTTSAQMKQCRELGVRFALDDFGTGYSPLRYLKDLPADTLKIDRGFVHNMLDDAQDRGIVDG
IISLARTFGCSVVAEGVETPAQARMLLDLGCDIGQGTGIASPLRASQVAQWVRD------
>tr|H5WR97|H5WR97_9BURK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Burkholderiales bacterium JOSHI_001 GN=BurJ1DRAFT_289
------------------------------------------------------------------------NGDLARTEARWQLALGGAGLGVAEWPLH
RGAGYSSQRWRTLHADGTQTA-TL-AAWL-TRVHPDQRAALQLEID-ALQQADSLSQQLQLRVG-EQWQWMELRLVVAEDSAQAPARLVATVSDVQARRS
ADERQRLSSSLFQNLHEGLLVVDADLRTLDANPTFCALLDTPREALLGSVPTLLRSASADPQRQAAMWASLRVAGSWTGEITDRRPSGDPVVLRTTVFTV
PDAQGAPRYHVLMVSDVTLQRQQRERLERQAHFDELTQLPNRARLAKLLTEAMAATDREGQMLTVCYLDLDHFKSLNDVFGHDVGDQVLVQLAQRLRGAL
RSRDVVARLGGDEFVLLLRA-NTEEARMAVERVMRVVGEPMALAAAPITLSASVGATVYPMDRSDADTLLRHADHAMYTAKQSGRDGHVFFDLEHNRRNE
ERVMALGRFQEALDRDELVLHYQPKVDLRRGQVLGFEALLRWNHPERGMLAPAHFLPLIEHTGLSARVGDWVMAQALEQLDRWRTEGLD-VSVSVNVSAR
HLQEPDFAQRLGELLARHSAPGGFLELEVLETAALADIGFTSALLERCAVLGVRFALDDFGTGYSTLTYLKRLPVQVLKIDRSFVHNMLDDPQDRAIVEG
VLSLARTFGCVAVAEGVETPAQARALLDLGCDIGQGSGIAPAMPAADAGRFVRE------
>tr|K9TJ12|K9TJ12_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Oscillatoria acuminata PCC 6304 GN=Oscil6304_2528 PE=
----------------------------------------------------------------------QTEEALRQAERKYRSIFENAVEGIFQTTPN
GQYLTANPMLASIYGYNSPEELIEVLDIHQLYVHPQRRSEFRRLL---QEQETVWGFESQVYRRDRRIIWISECARTIRDSNGEIIGYEGTVVDITQRKQ
AEAELHQRDGVAQAMNHLLTNTNTDRVYICELSNPTTAYNFGSRE--ESHPSLSSCSDCTAREHCQMWIRFKNGACSVVQLLNTLLVGESVAQEGTRSMV
ILVNNEFWGYIGFDGGALQRHHQEEMIRHQAYHDRLTGLPNRQLLDERLPMAIKIAKENKEQLAVMFLDLDRFKIINDTLGHAVGDELLQTAALRLGSCL
RDSDIIVRWGGDEFILLLEGITSEDAAQIAQRLLECLRPAFEIEGNQLYITGSIGMALYPQDGDDPETLIKNADTALYRVKEQGRNHYQIYSPAMSSEAS
ELLVLDNSLHEALKREEFFLEFQPQVNLKTGAVVGMEALVRWQHPHLGLVPPHTFIPIAEENCEIIKLGWWVLQQAIGQNKAWQDAGLPPIRMMVNLSTR
QFHHPDLAENVSQMLGEVELDPHWLGLEISETTAMHDPDLTDSILRQFRTMGISTAIDDFGIGYASLNYLKKFCFQTLKIDKSFVWDVALNAKEAAIVSA
IITLGQKLNMSVVAEGVETTVQRDCLLNLNCYEMQGYLFSPPLSGFNATRLLES------
>tr|K9SDL9|K9SDL9_9CYAN Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Geitlerinema sp. PCC 7407 GN=GEI7407_3614 PE=4 SV=1
----------------------------------------------------------------------ENITPLKEAEEKYRSIFENAVEGIFQTTAE
GRYITANPMLARIYGYSSPEELIKSLDIHQLYVDPERRRTFRQLI---DQEGAVWGFESQISRKDGSVIWISECARALYDSDGTLVGYEGTVEDISQRKQ
AEAELHQRDGVATATHHLLANPDYDRVYIYENHPHSE------------------------TGQLAMSMRFIQNQHWQYEVYQLLSQGRAVQQDQVLAMV
ILVDDEFWGYIGFDGSAVKRRRTEEIIRHQACHDQLTGLPNRSLFNYKLPVALSQAAHSDKLVAVMFLDLDRFKTINDTLGHAVGDELLKQVTQRLIRCI
RKGDLIARWGGDEFTLLLPEIDSEAVIKIAQRILEVLGPAFMLEGHELYATSSIGIALYPEDGKDPQTLLKNADAALYRVKDQGRNGYQFYTPSINYQAS
ERLALENNLHHALDRQEFLLYYQPQVDLQTGEVRQMEALLRWQHPEYGLVPPQRFICLAEETGLILPIGEWTLYEACRQARQWQRTAYPGVRVAVNLSGR
QFQQPGLVDLVARALAETGLSPEWLELEIAETTAMQNVEFTEEVLRELQEMGVRLSMDDFGTGYSSLAYLKKFPFHTLKIDRTFTEDVTTDPSDAAIITA
MLALGRSLNLEVVAEGVETEAQLEQLRSLHCRHMQGYLFSPPLPAEDALAFLQS------
>tr|D2UGC6|D2UGC6_XANAP Uncharacterized protein OS=Xanthomonas albilineans (strain GPE PC73 / CFBP 7063) GN=XALc_2960 PE=4 SV=1
------------------------------------------------------------------------LQRLSRGDEELRLACDMGGIGTWCIDTE
RRLMSLSEPTGAMFGLQRMQLSVDE---FLAQVHGEDRMRVAQLYEDAVHGRGEYNAVYRIHMPDGRVRWLAARGALVQTQD--GLRMTGAVQDVTERLA
VQARLLDAELMFDRNPLPYCVFAVDLRFLEVNRAAVGHYGYSRDEFLGMSLLDLHPREDAVRLLCDV-RTSRVGFSAPDVWTHRRKDGSLLSVCVHSADL
EF--AGMPARLILAEEVTQRLEHERELAFRASHDVATGLFNPHALAEALRA------HKCHAYAIAYVQLRGLALIGDTLGRATGDAVRCAVAERLRGLG
ERFGLAAHQPAEYFVLAVLEP--QALEQALQALLEAMSAPVQGGDFSLQLQAHIGVALCPEDAVDAEEAIGCAAQAAHAAQADGC-SLVRFDRSMSVRIG
ERLRLAGRLHEAIEREEFVLYFQPIMDADSGAPRVLEALIRWPQADGSFIPPDQFIQVCEDTGLILPLGRWVMRTAA-QARRELARGWSDLPVAVNVSAL
QFFDGDLVADLVQACADAELGIDGLHLELTESSLMRQPQQAREVLQRLRALGVRVALDDVGTGFSSMAYLRDLPLDTLKIDRSFIDGVDGDARNASICDA
LLTLGSSLGLDVVAEGVETQAQLQWLRAHGCGSVQGYLLGRPAPLEQVLQMLGAVA----
>tr|K8ZJ51|K8ZJ51_XANCT Two component system sensor-response regulator hybrid protein OS=Xanthomonas translucens pv. graminis ART-Xtg29 GN=XTG29_01260 
------------------------------------------------------------------------MDRLRRGDEDLRLAHAMGGIGTWRVEAD
RGHLLLAEQTGTLFGAPQLRVPLSA---FLARVHDDDRARVQQLYDEALHGNGEYNVVYRMHTLDGGLRWLAARGARVQGRD--GLCMTGAVQDVSQRIE
AQARLFDAELVFERNPLPFWLFAVDLRFLEVNQAAIRQYGYSRAEFLGMTLLDLHPPSEAERLLADG-REPRDGFDAPRVWTHRRKDGSVLSVRIHSADV
DF--GGVPVRLILAEDVSQRIAHERELAFRASHDVTTGLLDPRALAEALDA------RGQAGYAVAYVQVRGLALIGDTLGRAAGDAVRCAVAQRLRGLG
ERFGLTAHQPSQDFVLAVLDA--QQLPQALQALLEAVSAPVQGGAFTQQLQAHVGVALCPDDAAGAEETIGSAAQAAHAAQAEGR-SVARFERSMSARIG
ERLRLAGRIHQAIARQEFELHFQPIMHAGSGAPCLLEALIRWPQADGSYIAPDQFIQLCEDTGLILPLGRWVMQAAA-QARRQLALGWADLPVAVNVSAL
QFFDGDLVADLGQACAAAGLDADALHLELTESSLMRQPQQALEVLRQLRALGVSVALDDVGTGFSSMAYLRDLPLDTLKIDRSFISDLHRDARNASICEA
LLTLGRSLGLDVVAEGVETEEQLQWLRAHGCDQVQGYLLGRPAPLAQVIDALGTRN----
>tr|A0A064BTD7|A0A064BTD7_STEMA Diguanylate cyclase OS=Stenotrophomonas maltophilia M30 GN=DF40_016370 PE=4 SV=1
------------------------------------------------------------------------AEELKTGHAELRLAHQVGRVCTWYVDED
AALLRWSPLAREIFGVQTDALPVAD---FFARVHRDDAARLQQAFDQAFAGSAVLDQVFRLVLPGGEVRWVGARGQRVEVADS-ERRMIGALTDLSERYQ
AREQMSEVELLFDRNPAPFWVFDPDLRFIEVNDAAVRQYGYSRDEFLAMSILDIRPREGWDEVRGAI-QRAQVGDPDATVRLHRRKDGSVFEVRAHLSKL
DF--DGQPACLVLAEDVSERLAYERDLAYQARHNPATGLLNVRALTEQLDE------Q-EEGYTIAFVQLRGLQLVADTLGREIGDAVLQSMATRLGGLG
ARCGTLAFQPAEDFVFAIGAE--HDTQRVLDDLLQIVSAPMRGKDSLHQFEPRIGVAVHAGDGHTAEQVIGMAAQAAHAARAEGN-VVVWFDAAVTTRLA
DRLRLAGRIHAAID-NEFQLYFQPIRHAGDGSPAALEALLRWPQADGSFIPPNEFIQLCEDTGLILALGRWVIRAAA-KAQRRLVEGWGELPIAVNVSAV
QFFNSDLVAEFTRAQQDFGLARGALHVELTESSLMRKPAQAMQTMQRLHEQGIRVSLDDFGTGYSSMSYLQHLPLDILKIDRSFVADVETNPRNASICRA
LLSLGHSMGLTIIAEGVETPGQLDWLAAHGCDQVQGYLLGRPAPLEQIIDALDEVP----
>tr|A0A031H7V2|A0A031H7V2_9GAMM Putative transmembrane GGDEF EAL domain signaling protein OS=Stenotrophomonas sp. RIT309 GN=BW38_02922 PE=4 SV=1
------------------------------------------------------------------------AEELRTGHAELRLAHQVGRVCTWYVDED
AALLRWSPLAREIFGVQTDALPVAE---FFARVHHDDSARMQQAFDQAFAGNAVLDEEFRLVLPGGAVRWVAARGQRVAVVDR-QRRMIGALTDLSERYQ
AREQMRQVELLFDRNPAPFWVFDPDLRFIEVNEAAVQQYGYSRDEFLAMSILDIRPREGWDEVKGAI-AQVRSGEQDAAVRLHQRKDGTVFEVRVHLSQL
DF--DGQPACLVLAEDVSERLAYERDLAYQARHNPATGLLNVRALSEQLDE------Q-AGAYTIAYVQLRGLQLVADTLGREIGDAVLQSMASRLGGLG
ARFGLLAFQPAEDFVLAIAPE--HNTQRVLDDLLQIVSAPMRGQDSLHQFEPRIGVAVHADAGHSAEQSIGMAAQAAHAARAEGN-VVAWFDAAVTIRLA
DRLRLAGRIHAAID-NEFQLYFQPIRHASDGSPASLEALLRWPQADGSFIPPSEFIQLCEDTGLILALGRWVIRAAA-QAQRRLVEGWGELSIAVNVSAV
QFFNSDLVAEFARAQQDFGLARGALHVELTESSLMRKPAQAMQTMQRLHEQGIRVSLDDFGTGYSSMSYLQHLPLDVLKIDRSFVADVETNPRNASICRA
LLSLGHSMGLTIIAEGVETPGQLDWLAAHGCDQVQGYLLGRPALPEVARIPYTPVS----
>tr|A0A023Y7D1|A0A023Y7D1_9GAMM Diguanylate cyclase OS=Stenotrophomonas rhizophila GN=DX03_17645 PE=4 SV=1
------------------------------------------------------------------------TEELRTGHAELLMAHQVGKVCTWYVDED
ASQLRWSPLAREIFGIETESLPVAA---FFARVHREDAERMQLAFDNAFAGNGVLDEMFRVVLPGGTVRWVSARGQRVAVADR-QRHMIGALTDVSERVQ
ALARVQQAELLFDRNPAPFWVFDPDLRFMEVNEAAVKQYGYSRDEFLSMSILDIRPREGWDEIRGAI-SRATIGDQDAQVRVHRRKDGTLFEVRAHLSRL
DF--DGRQACLVLAEDISERLAYERDLAYHATHNPATGLLNTRALAAQLDE------E-GGGYTIAYVQFRGLQLVADTLGREVGDVVLQAMAKRLGGLG
TRYGLLAFQPAEDFIFAIRDD--HERQTALDTLVQTVSEPVRGQDWLHQFEPRIGVAVKDGDNVPAEQLIGMAAQAAHAARDEGS-VIAWFDTTVSSRLA
ERLRLAGRIHSAID-TEFELYYQPICHASDGTPAALEALLRWPQADGSFIPPGEFIQLCEDTGLILALGRWVIRAAA-QAQRRLADGWP-LPIAVNVSAV
QFFNSDLVAEFARATQEFGLERGALQVELTESSLMRKPAQAKQTMQRLHEQGVCISLDDFGTGYSNMSYLQHLPLDILKIDRSFVSDVETNPRNASICRA
LLSLGHSMGLTVIAEGVETPGQHQWLAAHGCDQVQGYLLGRPSPLVEVIARLETAE----
>tr|A0A0D0JLH8|A0A0D0JLH8_STEMA Stenotrophomonas maltophilia strain ZBG7B contig_16, whole genome shotgun sequence OS=Stenotrophomonas maltophilia GN=SN15_0414
------------------------------------------------------------------------AEELRTGHAELLLAHQVGHVCTWHVDED
ACQLHWSPLAREIFGVDVDALPLSE---FFQRVHREDGVRMQAAFDRAFAGDAVLDEVFRIVLPGGDVRWVSARGRRVMIGDR-QRRMIGAMTDISERYL
ARERADQAELLFDRNPAPFWVFDPDLRFLEVNQAAVSQYGYTREEFLAMSILDIRPREGWEEIRGAI-AEARIGEQDAKIRLHQRKDGTVFEVRAHLSRL
DF--DGRAACLVLAEDVSERLAYERELAYHASHHPQTGLLNTRALAEALDE------C-GEGYTVAFIQLRGLRLISDALGNDIGDAVLQAMATRLGGLG
ARFGWLAFQPAEDFVFAFSDA--HDAQNALDALVQIVSEPVRGQDSLHQFEPSIGVAVHPGDGLVAAQVVGMAAQAAHSARAEGD-VLARFDPSVNARLA
ERLRLAGRIHNAID-AEFELYFQPICHASDGTPAALEALLRWPQADGSFIPPGDFIQLCEDTGLILALGRWVIRAAA-QAQRQLVDGWADLPIAVNVSAV
QFFNSDLVGEFGRAMEEFGLARGALQVELTESSLMRKPAQAMQTMQRLHEQGICVSLDDFGTGFSSMSYLQHLPLDILKIDRSFVADVEINPRNASICRA
LLSLGHSMGLTIIAEGVETPGQLQWLAAHGCDQVQGYLLGRPAPLKTVIERLDAAE----
>tr|G7UW04|G7UW04_PSEUP PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Pseudoxanthomonas spadix (strain BD-a59) GN=DSC_15090 PE=4 S
------------------------------------------------------------------------LEQLQRNTEHLRLAQYTGKVGAWAMEQH
TRELVWGGDISAMFGLGQAHSSLRL---FGRHVHPHDRRMLARRFASAWRSHSAFSSEFRLVADDGTERWVVGRGGVVQDQAG-RQRMTGTLVDISERME
AMSRVSDAELIFDRNPLPFWVHDAHLRFLEVNRAATVQYGFSREELLTMELGDLCPGG-LPDASGLV-EDPAAGFDAAHVSQHRRKDGSTLQVRVYGSEI
RF--GGRDARLVLAEDVSERLEYEKELAYRARHDQTTGLINVQTLSDRLDQ------GQHPGYQVVYLQLRGLQPIRDSLGRETADDVLRTLAARLQQWA
DDFGLAAHQPDEDFVLAILHP--QRSSAALEAAIEAVREPIGQGDAMQRLDARFGLAQDDGSGQRAERIIDNAALAAHALETAAF-EISRYDGALARRYS
ERLRMAARLRAAIEQDEFELHFQPILRLADGSVAALEALVRWPQRDGTYIPPGDFIPLCEDTGLIVPLGNWILRRAA-QAQAWLQRGCQDLPVAVNVSAI
QMLQGDLPGELEAACLQAGIAPHALHMELTESVVMNRPEQGMAAMQRLREAGVCISLDDFGTGFSSMSYLRHLPLSSIKLDRAFICDVDRDERNASICSA
LLMLGHSLGLVMIAEGVERPEELEWLRRHGCDQVQGFLLGRPQPLESALLRVRGVA----
>tr|N6YZ03|N6YZ03_9RHOO PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Thauera aminoaromatica S2 GN=C665_11081 PE=4 SV=1
-------------------------------------------------------------------------ARSKRSF-DALIDSRREATCAWRPDT-
-TLLTCNERYAELLGTEAASLPGTR---WIDNVPEAKRAEVHAAIARMLQGAGTLTTDRRLRQADGRTRWLRWLDLPVLDEE--GRCV--EVHSIGQDIT
AQKEVELRLLAVEQSPNTIVITDTDGRIEYVNEAFVRTTGYTAAEAIGQNPRLLNAGKTSAATYADLWATLGRGE-WRGEFINTRKDGGTYTELATIAPI
KQADGSVSHYVAIKEDITGRREAEARIRQLAYYDTLTGLPNRSLMWDRLRHAIAASARSGASGMLMLLDIDHFKLLNDTQGHEVGDALLREVAQRLRGAL
REEDTVARVGDDDFAIVVENL--GADEKIAEHLHRCVTAPCELGLGPYHVGASLGLTLFRGRNAAADAVLKQAEVAVARAKDDGRNLIRFFSEAMQAVVA
ARADLELKLRAALAGNGFRLYYQPQLDR-NGRVIGAEALIRCFDAEGEMISPAAFIPLAEETGLIVPIGEWVLETACAQLRAWQRTSTAGLSLSINVSAR
QFHQPDFVGKVAAAIERHRIRPGGLEIELTESVVIGDIETTVLRMRQIKALGVRFALDDFGTGYSSLSYLKRLPFDQLKIDQMFVRDMEKDTSSEAIVRA
ILALSRSLDLKVVAEGVETAAQHELLLTRGCELFQGYLFGRPVPIEDWKAG---------
>tr|A0A098EMW1|A0A098EMW1_9BACL Cyclic di-GMP phosphodiesterase Gmr OS=Planomicrobium sp. ES2 GN=gmr_4 PE=4 SV=1
---------------------------------------------------------------------KKIRIELETSEQRYQSLFAYNPDGVFSMDHE
GRLLNVNEAILDLIGYTKEELIGTS---FQPLVAPPYLTDAIEHFNQALLGFQNYELQC--IRKDGEWIDLHITNLP-IKTDGEINGVYGIAKNIKKEKE
ALQLMEENESLFENNLDAVFEIALDGSFKNVNKRGEELTGYTENELRKIPFTELIAENIS--RVIDVFELAKQGNPLQAEQKLLDKGHNEFLMDLNVVPI
RK-QGEVNGVFAITRDVSEKKQLEKRMNELAFTDQLTGLPNRHWFYENLAKAAEKAKRYDRTLAVMLIDFDDFKGVNDLLGHQGGDLFLKKVSERIKSCL
RPSDRLSRHGGDEFIVAFENVTEAYMDRLAQKIFEAMKQPVELFEHEMIVTISIGISIQRDRMSNEETLIREADFALYSAKEKGKNNYQFFTQDLNQKVV
RKYQVESALRKAIAKDEFKFHYQPQVDLQTEKLVGLEALLRWN-PSFGPVSPVEFIPIAEETGLILPIGEWVLEEACRQIQEWKECGKLGVRVSVNVSAR
QFRDSQFNRKVEALLKKYRIDASQLEIEITESVMMNIE-ESSKVIRQLRELGLKIAIDDFGAGYSSLTVIKNIEIDTLKIDKSLIDDMLNNSRNLSILKA
IISVGKGLDTLVVVEGIEKEEQVELLKGFG-VIGQGYFYSRPMPPAKLESDWIE------
>tr|A0A023X2D4|A0A023X2D4_9ACTN GGDEF: diguanylate cyclase (GGDEF) domain OS=Rubrobacter radiotolerans GN=RradSPS_0872 PE=4 SV=1
-------------------------------------------------------------------------ARLRSFREKSQAILEQMEEGYFETDLF
GTITEVNDALTRTSGYSRESLLGSD---FRSYTSPEGLAMMQRNLESILASGPVRNVEC--DFPRGETLYFEVSGLM-RNERNRAVGFRGIMRDITRRKQ
TERSLRESENLFEQSVDALLLHDEHGRMVDCNEEACRSLGYTREELLSMSVRDFATRLIP--EDPTLWERAMKSEPGRIHGEHKRKDGTTFPVEVGVGA-
FE-LGGRRLIFASARDVTERKLLEQKLAHQATHDALTGLPNRYLFNQRLGLALKENGGGPGRVTVLFLDLDDFKVVNDSLGHRVGDALLVAAAGRLGSAV
PEGGTVARFGGDEFTVLLPNAADEQVILATQKIVEALRAPFALDGRELFVNTSVGAALGRPRDTP-EEVLRRADIALYSAKLSGKGRFEVFNETMDKKTT
ARLDLELDLRRAVKSGEMSVHYQPVVRLNTGELSGLEALARWEHPVRGTVSPAEFIPLAEETGLIHQIGAHVLESACARLVDWQTCGD--LRMSVNLSVR
QLQNPDLVEEVQAILSRTGVDPKDVVLEITESMVMQEA-EGLGTLGRLKDLGLSLAVDDFGTGYSSLSQLRRFPVDVLKIDRSFVDGLGRAPEDRAIVET
VVKLADALDLEVVAEGIETPEQLGRLKQLGCALGQGYLFSRPLPAGETERLLAA------
>tr|C3XAH6|C3XAH6_OXAFO Diguanylate cyclase (GGDEF) domain protein OS=Oxalobacter formigenes OXCC13 GN=OFBG_01230 PE=4 SV=1
------------------------------------------------------------------REEARA-QQLQEDSQLYRMAVERSEIGLWKASLS
MHFHFS-DKGGDIFGFVSFADIGFT--QFMDTIHSDSVEKIRGALRSAINSKIGFDIEIRINKPNGDFAWVNWKCFLIEENQTGAILLEGIALDITSHKT
TEKALAIASSLFENNRDGIFIADQTGRITVVNYQFTRMTGLSQEQIMGNHQWYLQPGISDSSCYSQLCDVIICTDHE--EMATFEKNREIEPTYLTIKIV
RDMDEKIISYIGVLLDISQNDFLEDHTRYMIEHDFLTGLPNRILLLDRLGQTLIAAERNHRRAAVMFLDLDKFKHINDTLGHAIGDRLLQQVAQRLTQCV
RKNDTVSRQGGDEFVILLSDIGEDDAAMVANNIMHTLSQNYQIENYEMSITSSIGIALFPEDGKEIDTLLKNADTAMYHAKENGRNAYQFFNAEMNLHLI
ERSQLEEDLKTALKNGDFFLEYQPIIDMHNQHMTGVEAFLRWNHPQFGILMPSRFLSIAENTGLIGPIGEWVINTACKQAKKWKDQGFS-KTVSVNLSSI
QLKQKDLLGTIKNALEENDLTPDFLELQITEGSITENIRTVIDLLNELRNMGVKIALDNFGNGCSSISHLKRVPIEKIKIDPSFIRALGTQSSDADVAGA
IIAMAKNLNLKVSAGGVETTDQANRLKEIGCDEYQGYVISPTLPAKEINRLQL-------
>tr|C3X4C3|C3X4C3_OXAFO Diguanylate cyclase (GGDEF) domain-containing protein OS=Oxalobacter formigenes HOxBLS GN=OFAG_01212 PE=4 SV=2
------------------------------------------------------------------QFKHRI-DQLEKERHFYQLAIERSDIGLWKATVA
LRFHFS-DKSGDLFGFVTFADIPFS--GFMNTIHPESAEKIRTALNSAINGKTGFDIEIRVNKPNGDFAWINWKCCLIEEDDTGKIRLEGIAADITSYKT
TEKALAIASNLFENNRDGIFIADQDRRITVVNRQFSRMTGLTQEKIMGNKPWYLQADIADSTCYSQLCDVIACTDHE--EMAAFEKNRQIEPTHLTVKIV
RDMDDRIISYIGTLLDISQNEFLEDHTRYMIEHDFLTGLPNRILLLDRLGQTLIAAERNRRRAAVMFLDLDRFKHINDTLGHAMGDRLLQQVAFRLTKCV
RKNDTVSRQGGDEFVILLNDIGNDDVALVANNIMHALSQNYQIENYEMSITPSIGIALYPEDGKDIDTLLKNADTAMYHAKEGGRNAYQFFNAQMNLHLV
ERTRLENDLKAALQNSGFFLEYQPIVDTQSGHMTGVEAFLRWNHPEFGILMPPRFLGVAEDTGLIGPIGEWVIRTACKQAGEWRDQGFP-KTVSINLSSI
QLKQKNLLSTIRNALKENGLAPDFLELQITEGSIMENVKTVSDLLHELRAMGIRIVLDNFGNGCSSISHLKKAPIGKIKIDPVFIHALGTGSEDADVAGA
IVAMAKNLRLKVSAGGVETDLQALRLKEIGCDEYQGYLVSPSLSAGEISPFLE-------
>tr|A0A0C5VD49|A0A0C5VD49_9GAMM Uncharacterized protein OS=Gynuella sunshinyii YC6258 GN=YC6258_00412 PE=4 SV=1
--------------------------------------------------------------------------DLESSQLRLQMAISASDMGIWDWNVQ
SRETYLTEGSR-L--VPPRDVTGEY--DYVDWVHPEDYQKKAELF--RHLKGKTTSYRVRYRVKNNGWIWVEDTGRAVRDRHGRVTRMIGTRREVTSEVN
HEQDLSLAASLFNHSDDAIFVMSYDFIVQSVNPAYCRIMNANRAELVNKPFSISAS----PQAYL-VMSSLNHKGYWQGEILEKRYNGESFPFKCRIDGI
FDSNGQLSHYIAIGTDMTEMRRSQVEIDYLSNYDKLTGLANRSHFHQVLNRHLQNPQAASDSLAIVVVNLDRFQAINDSLGYETGDLLLKDIASRITNLP
SPSAFCARVGGDEFVVIAEFFGSDKLNRLLDNILVEISRPVLADEHELIVTASIGVSIL--DGQNRHQLLNQASIALNRARHKGGNTYEYYQKTFKQTSV
DRLQLEKSLRRAIAENELSVNYQPKLNLMTGRIDSVEALVRWHHQSLGLIEPEHFIPIAEEIGLINAMGEQVLYKACDEASVWQQRGFGNIRVSVNLSSH
QLRQEGLYDSIYNILQTSELPAEYLELELTESVLIENMDHSVNTLNRLHALGTKIALDDFGTGYSSLSYLQKLPIDVLKIDKSFLHSQASGAGDTAIIKA
IIAMANSMSMEVVAEGVENNEQLQFLKDQGCHYAQGYLVSQPLPASEILNLLRHYN----
>tr|C0N1M8|C0N1M8_9GAMM Putative uncharacterized protein OS=Methylophaga thiooxydans DMS010 GN=MDMS009_286 PE=4 SV=1
-------------------------------------------------------------------RVSDARMALAESEERWSFALEGAGDGVWDWNIQ
TDEVFLSPQWKKMLGYQVDDIDNQF-ASCVSLLHPDDKSAVMEHLE-DYLAGNLYAPEFRMRCKDGSWKWLLSRAAIVQINYDNELCVLGWFYDVTEWVK
AQETLRLHASVFDNAWEGIMITDDHNRIITVNHAFTEITGYDQYEMIGENPSILSSGRQDKHFYQLMWQTIRQNGRWRGEVWNRKKSGEFYAEIHTVSAI
RNEQGDVTHYLGLFADITDIKNTERQLEDLAHYDALTQLANRTLLSDRLGQSLVHTRGNQTMLAVCFLDLDGFKPVNDMYGHEIGDQLLIEVARRLEHTV
RSGDTVARMGGDEFVLLIANIREDELDPILSRMNQKIAEKIHLGERVISVTASIGVALYPSDNVDADTLLRHADLSMYEAKQAGRNGYHIFDVNLDRQVH
EHRARTERIASALQNNEFCLFYQPKVNMQSHEVTGMEALIRWQHPEQGVLGAGEFLPVIESHQLIISLGDWVLEQAMHQVQAWMHQGLQ-IQVSVNVSAR
QIQHVDFIQKLEAVMARYPVPAGCLSLKYWKPRHLKPIRPL----K------L----------------WKRLPADSASLSHSMIS-------GRAILLC
LI----------------------------------------------------------
>tr|F5SUY0|F5SUY0_9GAMM Putative signal transduction protein containing a membrane domain, an EAL and a GGDEF domain containing protein OS=Methylophaga
-------------------------------------------------------------------RIDESKKSLAESESRWKLALESTGDGVWDVDLE
AGTASYSERWKKMLGYMDDSFPDTL-DETSEYIHPEDREQARLRFR-GYISGANYQDEFRMLCGDGSWKWIMARGMIIKIKYGGEECNIGWFYDITDRLK
NEEALRLHASVFDDAWEGILITDKDNRIISVNRAFSEITGYTQEELIGEDPKILASGRQGAEFYEEMWECIHTEGRWRGEIWNRKKNGEFFAEILTVSAI
ENDEGEITNYLGLFVDITEIKKTEHLLVNMAHYDALTQLANRTLLSDRLEQAIAIAKRSEKLLAVCFLDLDGFKPVNDEFGHEIGDKLLIAVAERLAQVT
RSGDTAARMGGDEFVVLISNINNDELDPILTRLSQKIAEPIKINHRKHHVTASIGVAIYPLDNVDGDTLIRHADLAMYEAKQAGRDGYHIFDAKLDQQMH
EYHSQLERLHLALIGEEFRLYYQPKVDLRHNRVVGVEALIRWQHPERGLLGAMEFLPIIEDHEFSIELGDWVLKTAFNQLQTWHENNLH-IQVSINVSAR
HIQHDAFLNKLESLLKQYKIAADDIELEILETSALETVQTA----Q------V----------------VRKLPVRTLKIDQSFIRDM---LGNEAIVKG
VI----------------------------------------------------------
>tr|D9SH94|D9SH94_GALCS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Gallionella capsiferriformans (strain ES-2) GN=Galf_1882 PE=4 S
---------------------------------------------------------LSLWFFWQ---VYRALGFIVQSDARIRAIYEAIGDAVLVGDRQ
GRVESINATAQRLLGWTEAEARGKLIVFELYDVHHQQR--VESPAESVLRDGIPIPNGMLLRRRDGSQLAVEDSAAPVRDEHGNAVGVVMVFHDVSKRYA
LLDELGAARTLFEQLPEGVLLFDESLAVITHNREAANLLEYASDALLLLQVSIEAMD--DQNAIAARKEKLQLTGIDNFESRYRTRSGRLMDVDVSVQVV
QLPNGRI-AFQTLFRDITEQKQTSAQIEHLAYHDQLTGLPNRRLLKDRLSQAVSSVVRRDAKLALMYLDLDHFKDVNDSLGHGAGDVLLQIVAERLQGCV
RADDTLARMGGDEFVLLLNGVNGDDVASIAGKIIHELSQPMRIGNDELRITPSLGISMCPQDGRDADDLLKYADVALYQAKQQGRATYRFYTQALHDQSV
ERVQLERLLRHALERNEFELYYQPQVDLCDGRIIGCEALIRWNHPGMGQVSPARFIPIAEQSGLIIDIGNWVMKQACHQAKRWHDQGWD-IKVSFNVSAR
QFMRGELMQSLRDALAESGVDPTRMEVELTESLLLD-PQGMGEILHEIRALGIQLALDDFGTGYSSLSYLRRFPISILKIDRSFVSAADNNADDAEMVKT
IIGMAHNLRMSLIAEGIETNAQRDMLETQGCEVGQGYHYSCPVPATEFSLLLQQ------
>tr|D9SEQ8|D9SEQ8_GALCS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Gallionella capsiferriformans (strain ES-2) GN=Galf_0975 PE=4 S
---------------------------------------------------------LSLWFFWQ---VYRALREIVLSDARIRAIYQAIGDAVLVADMQ
GRVESINATAQKLLGWREGEARGRLIVFELYDVHHQQR--VESPAESVLRDGCPIPNGMMLRRRDGSELAVEDSAAPVRDEHGQAVGVVMVFHDVSKRYA
LLAELRAARTLFEQLPEGVLLFDENLAVIMHNREAARLLEYSSKETLQLRVFIEAMD--DQAAIVARREKLQQTGRDDFESRYRTRSGRLLEVDVSVQVV
QLPDGRI-AFQTLFRDITEQKQAALQIEHLAYHDQLTGLPNRRLLHDRLSHAISSAVRRDAQLAVIYLDLDHFKDVNDSLGHGTGDALLQVVAERLLGCI
RADDTLARMGGDEFVLMLNDLNDDSASTAAEKIMHELSRPVCIGGDELRITPSLGISLCPGDGRDADELLKYADAALYQAKQQGRATYRFYTQALHDQSV
ERVQLERLLRHALERHEFELYYQPQVDLRDGRIIGCEALIRWNHPGMGQVSPGRFIPIAEHSGLIIDIGNWVMQEACRQPKRWHDQGRD-IKVSFNVSAR
QFMRAELMQSLKAALAESGVDATRMEVELTESLLLD-PQGMGEVLHEIRALGIQLALDDFGTGYSSLSYLRRFPINILKIDQSFVSDADNNPDDAEMVKT
IIGMAHNLRMSVVAEGIETEAHRALLAMQGCRVGQGYHYSRPVPAEEFSRLLQR------
>tr|F0RRU8|F0RRU8_SPHGB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sphaerochaeta globosa (strain ATCC BAA-1886 / DSM 22777 / Buddy
----------------------------------------------------------------------DHSKLLNEQSFLFNAIFWQAPIGISISHPI
NEVFSVNPRFEAITGRTSQELKAIG--WA-VITHPDDLEA-DLTQFKRLGEIQSYSLEKRYIKPDGTYVWVSLVVAALKIQSDHSYSHICLVQDISQRKK
AEQLLA------ESERSKSVLYDRDWTVLYVSKGCKALTGYDSESLLGNRDLSFND-LIVPCYQEDIRRELPLHQMFTYEYEIITRDGKRKWVWENGQGF
YTKQGEVEELEGIILDISNRKNVEQELMYNNEHDIWTGLFNRQYLERLLRLDAQLHPSLK--RAVLAVNISALHFANMTYGFQYTQEVVKKVSSALQVLT
SEQCLLCKTHEYRFSFYIKNYHTQDLIDFCKRISSLLESFLIIEG----INWGIGIVEIKKETEDVEQLLRNLEKALQQ--LQGDICCCFFDAAMEEQLY
QEEEITAELSGE-GSGSLFLNYQPILELATNKIVGFEALARLQIPSLGLISPLQFIPITEKTKLIIPLGDSIILQALRFLNTLQNSGYADIGISINISAI
QLLKHDFITHLLQMISSMQVDPQNICLEITESVFASNYQDINKVLGHLQSQGIQIAIDDFGTGYSSLARERELNINCLKIDKFFIDKLMTLTEEEAITGD
IISLAHKLGHCVVAEGIEHERQLQYLRKFGCDKIQGFLFSKPLDEQAALSFLKAQ-----
>tr|I2F7J2|I2F7J2_9THEM PAS domain S-box OS=Mesotoga prima MesG1.Ag.4.2 GN=Theba_2266 PE=4 SV=1
----------------------------------------------------------------------MLEQKLYEQGLTFDTIFQQAPIGIAISHRE
STVARFNPMFEKITGRTKDELMELG--WV-KITYPDDLDK-DLINFKKLGELSSYSMEKRYVRPDGSIVWVQMTVAPLIISNDDRYNHICLAQEITRRKE
MEADLL------ESERSKSVLYDRQWTMEFVSAGCSTLTGYSPESLINNKELAFCD-LVAPEYRESLWIELAKKVPLNYEYQTITAEGERKWVLEMGEGV
FGEGGEVEALEGIIIDITYRKRIEDRLKYNSEHDRWTGLHNLNYLETLLERDGKHRRLEN--RAFVSINLNTVQSLTATYGFHYTQELMREVADMLGQYC
TDRRMLFYTYENLFVFYLKDYKDEELTEFCRDIANMLESLLVAER----IGGGIGVVQIDKDSRDVDQLMKRLEKALNI--YDRDVGICFYDAEIEMEMI
REEEIKRELADE-NYGELFLQYQPILDLESNRICGFEALSRLKIEKFGLVPALEFIPIAEKTKLIVPIGRRAIIRALRFLRRLKDNGFGGVLVSINVSAI
QLLRSDFSENLFKMIDRTQVNPENIGLEITESVFASNYEEINRIIGGLKDSGIQIAIDDFGTGYSSLARERELNVNCLKIDKSFIDKLMCLDAKDTITSD
IISMAHKLGHCVIAEGVEHEKQRQYLHSWGCDRIQGYLIGKPLDEEAAIGVLKAS-----
>tr|L7VN44|L7VN44_CLOSH Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Clostridium stercorarium 
----------------------------------------------------------------------ALEQRLDEQTLTFDMIFTQAPIGIAISHHD
KPVIKVNPMFEQIVGRTEEEINIIG--WE-KITHPDDLGE-DAENLKKLGEIGMYCMDKRYIRPDGSVVWVHMIVAPLILPEDRIFGHICLVQDITDRKI
FEEALH------ESERSKSVFYDREWTMQFVSDGCYALTGYRPESLLNNRELSFKD-IISPEYREALWNKLAQRQQFKYEYEIITATGERKWVLELGQGI
FNDNGEVEALEGIILDISDRKAVEDALKYNNEHDRTTGLYNREYLISLLENDLKKKKDIK--KALIGVNLTAVQLLTVKYGFNYTQSLIKKAAAVLSALC
SENRQLFHVRENRFVFYIVGYSDNELVEFGNAVAETLESLFITDR----INGGIGIVEIDQHQINAELLMRRMDRSINL--YDNDYVICFYDDELESMVN
REIEIERALFDTGTKDELFLHYQPILDLKSGSICDFEALCRLKTEKLGLVSPAEFIPVAEKTKLIIPIGEKVIINAFKFLSRLNENGYGNISVSVNISVI
QLLKPEFTDRLLELIAKMNVNPGNICLEITESVFSSDFARINKAINKLRTAGIHIAIDDFGTGYSSLAREKELNVDSLKIDKYFIDNLLDANPDKVITSD
IISMSHKLGHCTVAEGVEHDIQLHYLMEHDCDRVQGYLISKPLDENNAIEFLKNY-----
>tr|E3PXK6|E3PXK6_CLOSD Str. DSM 519 chromosome, complete genome OS=Clostridium sticklandii (strain ATCC 12662 / DSM 519 / JCM 1433 / NCIB 10654) GN=CL
----------------------------------------------------------------------ILEQQLQEQGLTLDLIINQAPIGIAISYWR
DEYCIFSPMFLNITGRSRHELISLG--WE-NISHPDDLDD-ELVYNNKLGELESYTIDKRIIKPDGSVVWVHLIMSNIYLSPERPCNQICLIQDITQRKS
FENALI------ESERSKSVLYDDDWTMQFVSEGCYELTGYKADSLLHNKELSYND-IISPEYREILSNELRNRDSFSYEYEIITSTKEKKWVIELGEGI
FDKDGNIEALEGIVIDISYRKAMENELKYSNEHDRWTGLYNRNYLEELILRDIKSQSKAN--LALVGINLSAVSSLNKMYGFQYIQELIKVIVENLNVHV
TKERLLFSTYENRFVFYVNNYEDEELKEFGECLAKTLEPYISAER----VGVGIGILEIGYE-HNVDNLFKKLEKAIEI--NDRDYWVCVYDNKLETEVM
REQEIKHELTLH-IDGSLYIQYQPIFDLKANKVTGFEALSRINSEKLGFISPLEFIPIAEETKLIIPIGEKIISKSLDFLFRLNILGFDDIDISINLSVI
QLFKKDFPEKLFKIIKEKNVNPQNIILEITESIYSSDYDYLNIILNDLKRIGLKISIDDFGTGYSSLSRERDLNIDCLKLDKSFIDKLMYLSPEEAITGD
IISMAHKLGHSVVAEGVEHEKQMNYLKSSDCDRIQGYFISRPLDEEKAIEFLK-------
>tr|C6CKZ2|C6CKZ2_DICZE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Dickeya zeae (strain Ech1591) GN=Dd1591_0762 PE=4 SV=1
-----------------------------------------------------------------------MTGSAWNSESLFQAILDRCPVGIAVINYD
GHYVTVNPAYGAIYGYTQEEMAGRS--FT-MV-FPESARD-SVLARHRQDEGGTLGGEWTVMRRDGVILTIWSESVP-FAQHGHRADRLVYVLDITERQK
AREQMKIAAAVYESTQEAIIV-NTSRSIISINPAFTRLTGYSAADVVGQPSYIFRSDRHDADFYTAMWRT---------------VDEDGVWVGEMWDVI
KDAAGTPINYVGVFSDITQRKKQEALIWRQANYDAVTTLPNRHHFQDKLERAVEHAKQSGRPMALMLIDLDHFKSVNDSLGHRAGDALLLAVSNRLTDCV
QGADTIARLGGDEFAIILTDLHQGDSGCLARTLLAQLAQPFNIDGESMLVSASIGIALFPNDSDTLEELFKNADQAMYAAKSAGRNCFNYYTPALHQAAR
ARLRLTNDLRTAIQCGQFEVYYQPIIELSTNKVVKAEALVRWRHPIRGMISPAEFIPLAEDTGLIVPLGDWVARQAITQLAQWRKIFDPHFQVAINQSPV
QLRSKDFTEMTWQELAQHGLEGNAVIIEITEGLLLNAESRVNDNLHLFRDTGIQIAIDDFGTGYSSLAYLRKFDIDCLKIDRSFVEDLDGVGFE--LCVA
IIAMAHSLGLKVVAEGVETQQQCDTLARIGCDYAQGFLFSRPVPAPELTILLLAA-----
>tr|A3WPN1|A3WPN1_9GAMM Signaling protein with a ligand-binding sensor domain, PAS, GGDEF andEAL domains OS=Idiomarina baltica OS145 GN=OS145_12290 PE=4 SV=1
-------------------------------------------------------------------RKARAYHKLTEAHTSLHQLLNGTQQQVWHWNL-
-----VNSEVERVHIFPLDGGLGQS---DQSNVHPDDIGELTAALE-QVKSGSHYQCTYRI--KNGQWLWVLERGELVAATSGKPIKVQGTLSDISDIIN
SDERIDMLATSLTNISDGICIFDRFFRKREINTAYERITGYQREQVIGQAFAL---PHYDRDFTDQIKHTVLREGSWSGEVTDFNADGAELLLELTLDAV
RNDSGEIKLIVASFSDITERRNTENELRRLSNTDSLTGLPNRSYFQVSHSN----LVRKRVAHALLLFDLDDFKRINDSLGHEVGDELLCRVADRLAELG
RRQDTLYRLGGDEFGILIEDNTDNVISTIAQQVNTEIAKAYRIKGHEIALGSSIGIVLYPHDAHTSQELLQKADTAMYHAKQRGGNCYQFFNASMNENAI
QRLVLESQVRHAIRTHQVEVYYQPKMEIATGHISGIEALARIRDEYGQFISPAQFIPLCEETGLIIPLSEQVLRTACRDMRQLLTLQGAPRSVAINLSAR
QFTQSSLALFIEQVLQEEEMHPRHIEFEITEGMVMSDPERAIAMLENLADMGVQLALDDFGTGYSSLAYLKRFPMHTLKIDKEFVDDITFDERDRKMVES
IIGMAHNLGLKVVAEGVEEKAQLDILEQLQCEYIQGFYFAKPMSAEALIEFIT-------
>tr|F3LJB3|F3LJB3_9GAMM EAL/GGDEF/PAS/PAC-domain containing protein OS=gamma proteobacterium IMCC1989 GN=IMCC1989_1867 PE=4 SV=1
---------------------------------------------------------------------------------YSRFLFDTLRTAVLYLDQW
GRVRSANDMAKRLFND--PHLSGKTAYWKPIHVHQ---E-I----LSVARTGNSVTELVEKVEIDGQERWFQTDKIAVENPQHGFNGVVFTLDDITELKQ
HQLSLAKSEAFIQNSRDAIWRIDIQAMMGDYNDVFHELYCLDSSTGVGGLPRDISIKLLSVEFVE-------NELQINKVITFLDNECQPRHLKLSAQGV
V-EEECLVGIWGVTQDITERREYIEQLEYQNTHDLLTGLPNRTSLQQSVESSIEVLSEN-EKLIFMIIDLDSFKDVNDTLGHDVGDKIIQEIGPRLQKVL
QDSSVIARLGGDEFAIMLTGVEDASIDRIARLLLSCIRQYFYVNNTEVEIRASVGVAIYPDQADDFSTLLRYADVAMYCAKEDMSG-VAFYDTERDAHSP
KRLSLMSELGKAIRGSDLTLYFQPKISLHDQRIVGVEALSRWVHPTMGFISPAEFVPVAEMTDLINDMTDWVLNESLRQIKEWRDRGLE-IAVAVNISAR
NLQQEGFCDMVRELLTRHDLPASCLELEITESTIMKHMEKTLLVLKELNEMGIDLSIDDFGTGYSSLAYLKRLPVKRLKIDYSFIINMMENEQDQVIVSS
TIHMAHNLGLWVVAEGVETEALQHQLAGMGCEQAQGFHIARPMPANELEEWHHN------
>tr|C5BQV7|C5BQV7_TERTT Eal and ggdef domain containing protein OS=Teredinibacter turnerae (strain ATCC 39867 / T7901) GN=TERTU_1023 PE=4 SV=1
----------------------------------------------------------------------------------L-ALLDALRSVILYFDRW
GTVIHGNRRACQWR--PLEQLVGRTFHWQPEQTQR---E-M----MQVVRTGIPSWGVKERSGKGADCRWFSVDKIPTLNKLGEVTGVMLVINDISESVV
KERALEESDAFIANSADAIWCYEVRAILVECNETLARFFGVTHTRDVIGLPSRSGSSYQDVAFID-------NGYRLEKEFSRVDRTGMCGYMQSSAIGV
V-ENGLLMRAWGITRDITDQRTHTDRMEYLANHDSLTLLPNRTLLYSTMEQTIANAKND-QLMALMIIDLDRFKEINDTLGHRAGDSVLQQVGPRLEGEM
VEEGLVARLGGDEFAVFLPRVRNHQALVLGHRFIDSLGEPFEIETFRTEVTASIGISMFPDQGRDVSTLMRYADVAMYHAKRALKG-VAVYDPEFDPHSP
TRLEIMGALRRAIRESQLELYFQPKIDLLTHRVTGFEGLLRWHHPEIGTVPPVDFIPIVEKSNLIYPLTCWVMAESIRQCAIWRREGHD-ITVAMNLSAS
NVTDERLLAELRQLLTQYDLPGHCLEMELTESTIMNDPERALTALKKIAALGVHLSIDDFGTGYSSLAYLKRLPVGTLKIDKSFVMDMLIDEQDEIIVNS
TINLAHNLGLSVVAEGVESQEIYQRLQDHKCDSAQGFLIARPMPAADATRWLLN------
>tr|Q21HJ2|Q21HJ2_SACD2 Diguanylate cyclase/phosphodiesterase OS=Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) GN=Sde_2577 PE=4 SV=1
----------------------------------------------------------------------------------A-GILDAMSGMVFLLDRW
GVIQLANSLALKLC--NGENPVGKNVGWDASACQR---D-I----LYVVRSGLAKRGSVENIFVEGQMRCYCVDIAPASKHAHSPVGVFLTLTDITHQED
SLRALRDSEAFIASSADAIWAYELRALLTECNEKMARIYGVSDITSVVGRPYLNGSNKEDIRFVL-------NNYRVEHEFTRIDKFGELGYMLSSATGV
I-ENGKLMRAWGSTRDVTDQRRYLDRMRYLANHDTLTSLPNRNLLYKELERVLSNRSQN-QKVALLLVDLDRFKEINDTLGHQAGDKVLKQLGPRLEVEL
GDPGMVARLGGDEFAILLSNIRNQHAVVTAHRFADAIAERFDLDTFSTELQSSIGVVICPDQAEDVSTLMRYADVAMYHAKNNMKA-VSIYDAEYDPNSA
KRLTVTGALGRAIREEQLVLFYQPKVDLKTHRVYGFEALIRWIHPELGFIPPSDFVPMVELSSWIYPMTLWVLEQTIKQCAMWRDAGLD-LTLAMNLSPR
NLADDRIVNDLEVLLKKYNVRGGMLEMEITESMLMSDPNRASRILERINKLGVRLSIDDFGTGYSSLAYLKRLPVKTLKIDGSFIMNMLESEQDEIIVKS
TIHLAHNLGLDVVAEGVETLEVYDRLNSLECDSVQGYYIAKPMPIESVGAWLAD------
>tr|I3I9X9|I3I9X9_9GAMM Sensory box/GGDEF domain/EAL domain protein OS=Cellvibrio sp. BR GN=O59_002588 PE=4 SV=1
---------------------------------------------------------------------------------ALSSLFADSPIPSFITDKQ
GVIVNINESCERLFHLSAEQAAGFYSVYQGKPQTL---E-M----SYSL------GNIHRSRFICDKQIHFRVSFVPIPDRQGKVAQVLVQLQDLSREKS
ARDALQESEAFITNSSEAIWCYDMNARLVEANKVLVNMLGVDSLDDILGTGIDSGSYVFDIFFVK-------NNYVMVHDIIRQDARGKSFYFQICCTGI
V-ERGQLKRVWGTTKDITARRRYEEKLRYQSYHDSLTALPNREKLYADMQACFEQRSAE-QISALLLIDLDRFKEINDTLGHNVGDHLLQLIGPRLANEM
AEPGTVARLGGDEFAVFLPRIRSHQAVVFGHRLLDALSQEFDLEGFTAQISASIGIAISPQQAQDQHTLMRYADIAMYYAKSQMLG-LAIYSAEYDPHST
KRLSIISELGRAIRENQLCLYYQPKILLDEKRCYGFEALIRWIHPELGFVPPADFIPMAELTTLIHQLTAWVLEKAISQCRTWQDQGMS-LSIAVNLSAR
NLMDDNIPKLVERLLIKYQLPAARLELEITESSIMTDPARALRNLDALHALGVHLAIDDFGTGYSSLAYLKRLPVQTLKIDSSFVRSMLEDLQDELIVNS
TIHLAHNLGLMVVAEGVENEALLNRLSEMGCDEAQGFFIGKPMSVINTNEWLVE------
>tr|F2KFF4|F2KFF4_PSEBN Putative diguanylate cyclase/phosphodiesterase OS=Pseudomonas brassicacearum (strain NFM421) GN=PSEBR_a2263 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------GQGHVLELIARSTELTEVL-
--DSLA---HLVESQLEGILLLDEEGKHLSLPKAYCQLIGIEIGPNVGREPVIVTDIEQDPEAYRSLVAPYGFRACWSTILSHERKVLGTF--ALYANTV
RSPSAAETQLIDLATPLIERQLTEKRIRFMGDHDALTGLPNRTLLEDRLKQAMLYAQRYNRLVTVVFLDLDKFKLVNDSLGHSAGDELLKTVAQRLLGCV
RRTDTVVRLGGDEFVIILFDQPSDGVTPVLHKIQEAILRPIQLGGHTLHVTCSMGLATYPADGSDTDTLLSNADAAMYRAKELGRNSFQFYTSEMNNKVQ
GKLAMQDGLRSALYNDEFLLLYQPQVDLQSGQIIGVEALIRWQHPELGMVSPIKFIPQAEETGLIVPIGDWVIHTACRQNKAWQNAGWPPITMSVNISAR
QFIERDLIDRVMHALQETGLDPMYLELELTESLIMQDLQQAISKMKALQAMGISLSIDDFGTGYSSLAALKSFPIARLKIDQSFVRDLPDNENDKAIATA
VISLGHKLNLKVIAEGVETEEQQTFLRDNGCDEIQGHFFSKAVSAEEISRLLRTSGVSE-
>tr|D4H6H1|D4H6H1_DENA2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Denitrovibrio acetiphilus (strain DSM 12809 / N2460) GN=Dacet_2895 PE=4 SV=1
--------------------------------------------------------------------------DLTEAQAYMKKLINNAAAPIATWDRN
GNITLFNNALEKLSGYDSSNMLGKHLSHIYNIFPHAKVA-LENN-DTDVS--SSAQFESALHRESGENSYILWNITDIFSYAGTILQ----GIDITEIKN
AEEKTLLASKVFDNTLDGIMIVKKDGEIVSCNKAFSSTTGYSEEEIIGKNARMFRPGIHPDYFYEDLWKNLFKYGKWDGEVWQKKKDGEIFPTLMSCSSI
RNSEGEITEFISVLHDITEQKRYEEQIKYQATHDSLTGLPNRIYFTDKLAEQIPKNHL-PSCIGIMFLDLDRFKNLNDTLGHTTGDKVLEIIAERIRNTV
HGPDMAARFSGDEFTVFFTGVKNDALIEMVKNVTKRISEPLHIQGYELFIQTSAGISVYPDNGLTASELIKNAEIAMYQAKQTGKNNIQLYTDGLDETIR
DRFIMESKLNRAIENDEFSLHYQPKIDLATDSVMGMEALLRWHNPELGFIPPDKFIPLSEDSGLILPIGEWVMKRALSDTAKLHKEGFADLKIAINLSLR
QFMKKGLVEFVEKSIETAGLNNRNVEFEITENIFTEDLSTISRIMNEISNLNIKFAIDDFGTGYSSIGYLKKMPISTLKIDRSYISKIDSDTDSESIVSS
VILMSKSLGLNVVAEGAETESQVNMLKDMGCSIVQGYYYGKPMPYDEFLEFVRN------
>tr|A0A071L9V7|A0A071L9V7_9PROT Uncharacterized protein OS=Campylobacter mucosalis GN=CR66_06610 PE=4 SV=1
--------------------------------------------------------------------QKAINDKSIAELKYFKNLAWASDVIPLEFDVK
SQILRIGEGFTKMLGFTELPQIDADFDYIKRVLF-DEYLDFKDFFA-RIQTPDNYEGDVKFLTSEKGVLWLHIKAKVTKKDEGNLEFISGIIRNVTDKKV
ALIYQDLASKIFSYSKDSIAILDLDWKFIDVNDKFCQNSGYSLNEIIGLNAVMMRSKLNNEELYKNALESVESIGYWQGKLWNRRKNGEDYLESVNMLTV
YDDNASPVCYAIIMSESSEIKTTQDYLEHIAYHDPLTKLPNRFLFNQKLDRAVLNAKG-SKFVAIAYLDMDGFKAINDTYGHKAGDKLLTEISNKIDALF
DERDMFARVGGDEFIAIIE-HEKGEVYEMVENMLRIACEEVDYNGNLLKISASIGVSVHNINQISPEVMIEQADWAMYQAKLSGKNRYHIFDSSKDKNLK
SQYEDSNKILVALERGEFFMEYQPEINLKTNEIVSYEALIRWNRGT-DIVYPNDFLSLIKKQNVLDDLSFFTISSALKAQSQWVKDGLR-ANICVNLSIT
QLCDDKFFIRFKELLKNPNFNPNALSFEIIDANSTSSLETASKFLQRYKRLGVKFILDDFASKSSSFEALELLPIDRLKADKHICAHMFSNKKAFITIKM
IKNIANTFNKNATIKNLKDLNMLKILVGLGFTNFQGNFFARAIKPQDVPSYH--------
>tr|J4V8Q9|J4V8Q9_9PROT Diguanylate cyclase (GGDEF) domain protein OS=Campylobacter sp. FOBRC14 GN=HMPREF1139_0182 PE=4 SV=1
--------------------------------------------------------------------LARLQERYDADQKSFKNILWASEAVVFSWSKT
SGVMQVDDGFAKMLGFNDANELVLDFKRFKALLA-GSYASFEQLFE-GMRFESVYFGELKFHAKDKSAVYIGVRARALEFENGEACLIKGAFKNLTQQNQ
AIIYQDLLCKLFSYAKEGVATLSADLKIIDANDAFCQMCGYERDE---KDVAFI--KPGLSGLTQDMT-KAAKGGFWQSKILNKNKNGENRFELARLAPL
NDVQGGLFCYVLLVSNINDIESNQDYLEYIAYHDPLTRLPNRILFTRKLEDMLAKND---RHIAIAYLDMDGFKGINDTYGHQAGDKFLTEISSGIDRLF
DERDMFARIGGDEFVAIIV-YKNGEVYEIVQNMLRIASSEVWYENVKLQISASIGVSMASLAQTSAENLLEQADWAMYQAKLGGKNRYYVFDASKDRNFK
NQYEEASKILKALRDDEIFLEYQPEIDIKTGKILSYEALIRWQSEG-RVIYPDDFLPLIKKQYIIDDIALFSIKKALEAQILWSKNGKD-AKACVNLNIE
QLCSDEFFVKFKELANDKRLNFSELVIDIVDANAVKDLQPAQKALQRYKRFGVRFVLDDFASHSSSFEALGLLKVERFKVDKQLSRQAFDSKASIMTLRM
IKQISDVFGLKATIKNIEDKKTLEILCGFGFECFQGNFFTKPLRLDEALRYE--------
>tr|U2GTW9|U2GTW9_9PROT Diguanylate cyclase OS=Campylobacter concisus ATCC 51561 GN=ATCC51561_52 PE=4 SV=1
--------------------------------------------------------------------MLKLQERFEKQSKESKALLWASEANVFTWDKR
SDMLNISDELSKILG----TQSTLNFEQAKSVFV-DEFDSFYSFFE-SLRDAQTYIKDIKLYSIDKEILHFRLRAKALEYEFGEVSLIKGTLRDLSLEDS
FFVCQDLLAKIFSFSKEEVVLLDEEMRVIDANDAFFESAGAK------KDITFI--KQGLSDIKYQIIETINQGGSWSGKVWSENNKNKSKLEVIEILPL
IDANEKKTGYIMLAMLANNEAQNEKYLEFIAYHDPLTKLPNRFLLYNKLNSLIQKNE---QKIAVIYLDMDDFKSINDNFGHQIGDKFLVAISEKIGAMF
NGKNIFARIGGDEFVGVIN-YENGEVYEIAQNMLRLASDEVKIDELKLKASASVGIALADS-ELGADDVLQRADWAMYQAKISGKNRSYTFDAKKDVYFK
SQYEDGSKILKALDAGEMFLEFQPEISFSTGETLSFEALIRWRKDG-EIIYPSDFLPLIKTSSASSNIALFTIKEALLARKMWLENGIS-AKVRVNLSVK
KLFTEEFWHKFKAIFDDKSLDPTGLIIDVIDAATATNLEVLEIYVRKYKELGIHFSLDDFASYSSSIEALGMLKTNRFNIDNKFCKHIFNSKEALESINM
IRFVADKFGLNATIKNIDDKRTLEFLLGLGFDKFQGNIFSLALLAKDAASFK--------
>tr|U2GJR0|U2GJR0_9PROT Diguanylate cyclase OS=Campylobacter concisus ATCC 51562 GN=ATCC51562_177 PE=4 SV=1
--------------------------------------------------------------------IAKLQEKYDAELKYFQSILWASQALVFSWDKK
SDTLYIPNAIAKSLGYALNGDMSINFERAKTIFV-DEFVSFKDFFD-LIKKGEVYDGEVRFYRADKEIIYVRIRAKAVAF-DGEVSVIKGTMQDLSVQNS
FFSYQDLLAKIFSYAKEQIIMLDDEFRIIDANDAFFDTLDISRDKNFIKDIINF--KNGLKDIKDEILNSLKITGFWQGLIHDVRS--KNRLEVISISKL
LNAFGDQEGYILLASSANDDCYNKEYLEFIAYHDTLTGLPNRFLLFNKLENLLKQAKK-SLKVAAFYVDFDNFKSINDGYGHQVGDKILIEISKKIDEIF
PKQGIFARIGGDEFIGAMP-YENGEIYETAENILRVGQSKISIDDDEKKLSVSIGISLSGD-ALSVDDLIERADWAMYQAKLNGKNKYYVFNSKKDTYFK
NEYRDDSKIIEAIDAGEMFLLYQPEIDIKSGEVSSFEAFIRWKNGD-KILRPSDFLPLAKGSKAVVAIALFTLKDALKARAVWLKEGIN-AKVRVNLCIK
KLMTSEFFEKFKKLLKDEQLDANGLIIDIVDSASGVNLDDVVRYIDAYKELGVSFSLDDFASYSGSVEALGMLKTNRFNIDKRFCKQIFDSVEALKTIRM
IKYVSDTFNFDVMIKNLEDKSMLEIFVGFGFSRFQGRLFAPELSLDDVLKFK--------
>tr|U2EYJ5|U2EYJ5_9PROT Diguanylate cyclase OS=Campylobacter concisus UNSW1 GN=UNSW1_173 PE=4 SV=1
--------------------------------------------------------------------VSKLQEKYDIELKQFQVILWASEALVFSWDKK
SDTLYIPNAIAKSLGYTLSGDMSVNFERAKTIFV-DEFTSFKNFFD-LIKKDDEYNGEVRLYRADKEIIYVKIRARAISF-NNEVSVIKGTMQDLSMQNS
FFTYQDLLAKIFSYSKEQIVMLDDELRVVDANDAFFDTFNAKKDEIFLRDITSL--KTGLKDIRNEILLSLKKEGYWQGLVYDVQS--KNRLEIISISAL
LNAFSEHEGYLLLASSANDERYNKEYLEFIAYHDPLTGLPNRFLLFNKLESFLKQVNK-GIKIAAFYVDFDDFKSVNDGYGHQVGDKLLVEVSKKMDEIF
PKQGVFARIGGDEFIGIAS-YENGEIYETADNILRIAKEKNSIEEGDIKLSVSVGISLSCD-ALSADDLLERADWAMYQAKLDGKNKYYLFNAKKDNYFK
NEYRDGSKILKAIEAGEMFLLYQPEVDIKTGKIISFEAFIRWKNGD-KVLKPSDFLPLTKASKAAIAIALFALKNALKARELWLKEGID-AKVRVNLGIK
KLLTADFFEKFKEILKDENLDASGLIIDIVDAANGANLDDVANYIDAYKELGVSFSLDDFASYSGSIEALGMLKANRFNVDKRFCKQIFSSKEALETMRM
IRYISSTFKLDAMIKNIEDESIFEIFLGFGFTRFQGRFFATELSLDEVIKFK--------
>tr|A0A0E1GKG4|A0A0E1GKG4_CAMFE PAS sensor-containing diguanylate cyclase/phosphodiesterase OS=Campylobacter fetus subsp. fetus 04/554 GN=CFF04554_0367 PE=4 SV
--------------------------------------------------------------------QKLTEDIFKDKINKYQNLLWATSGMSFEYDIK
KRVYTFSNSFINLLGYRNSDDLVINSENISKIVYKSDLDKVVLAWDNYLKGSPSINTEIRCIAKDGRYIWVCIKAKTATSLDGTPNLISGMLEDITIKKE
SEAQLQLIASVFSYSREGIMITDLNGLILDVNDAFVQITGYGKEEVRGKYPNMLKSDRHNNKFYAKIWADIKQSGFWRGEIWNKRKNGQIYPEILTISAV
KNQLDEVQHYVAIFYDITYIKENETRLEKIAHYDPLTKLPNRFLLLEKLAIAMNNVKENGKKIAVIYLDLDGFKKANDTYGHNCGDGLLVAISSRMQGII
SGDNLIARFGGDEFVALINDVSDNALIKILDDMLLAARDKTVINSNKIQVSTSIGVAFYDRSDISMEDLLKRADWAMYHAKLSGKNRYYIFDENRDEIF-
NQYNESLLSKDKFDSDEFFLMYQPVVNIKDAKITSFEVLLRWKHPQKGIMLPVDFLHIFSDKVWFDELTIWIIINALRDSEDIFNKG---IKLSINIPFE
QLNDEIFFAKFKDLYKNSDLRFDMLEIEITDAMSVKDIENEILNLVIYEDLGIKFVFDDFGSSLSLANTMKTAPTNTYKINKKYALELLDRADNVDMLQT
ILNICSAFKKRAIIKGVENEYIYNIVANIGFVELQGNFISKPIFKDDISDMI--------
>tr|A0A076F9E2|A0A076F9E2_9PROT Campylobacter iguaniorum strain 1485E, complete genome OS=Campylobacter iguaniorum GN=CIG1485E_0427 PE=4 SV=1
--------------------------------------------------------------------QKVMEDIYKERINKYQNLLLSTSSMPWDYDCK
TQILTFSHSLALLLGYDGLNELVVTYPNLSKVIHKNDLIKLDNAYESYVNGSDNFFVELRFIKKDGEPIWIQIKGRAISKINGVPVQLCGMLEDISKKIE
SRSQIKLIANIFSYAREGIVITALDGTIIDINDSFTHITGYAKEDVVGRTPSILKSNRHDGAFYKKMWDDIQDIGFWHGEIWNRRKNGEIYPEILTISSV
RGEDDEPLHYIAIFSDMTRSKDNEEKLRKIAHYDTLTKVPNRFLALEYLKDFMDNADKTQRKFALAYIDLDGFKIANDIYGHHCGDAVLVKMTNFIKDAL
RPNDILARFGGDEFVIIINDVENAEFTSLLDSIIIAASNEIVVGSNKIALSASMGVTIYPQTNLSINDLLKQADWAMYHAKLAGKNRYYIFDTQKDMLF-
DYYNDLLISSDKFEDNEFIPMYQPIIDVGLGAITSFELLVRWKHPVKGIMLPLDFLNILRNKKWFNEFSIWVIKNAINAINSLPNSD---IKFSVNVPFY
QLMNDEFYAKFEELYVDMA-PFSRLVIEITDTPLAQYPDIKPGIFDRYKKFGIDFVFDDFDANTAVVNILRDIPASRYKISKSYATTLLTDVKNIEIIKN
ILCLCNAFGKIAILKGIENNYIYKIATDLGFKRIQGNFISKPVLSQDIKAVM--------
>tr|A0A071L4N1|A0A071L4N1_CAMHY Uncharacterized protein OS=Campylobacter hyointestinalis subsp. hyointestinalis GN=CR67_08140 PE=4 SV=1
--------------------------------------------------------------------QKLLEDMYKEKINKYQNFLWASSAISFEYDCK
SQTYHFSNNFFNLLEYKP-EELTIKFETLAKIIHQNDLDKFYKMQTKCINGIDNLYLEIRFVSKDERIIWMAIKGKRLNSQD--IGNICGIIEDISKRIK
TESQLKLIASVFSYSREAITITDLHANILDVNDAFTQITGYSKEEVIGKNPNILSSNRHNVDFYVDMWKNIKEFGFWRGEIWNKRKNGDVYPEMLTISSV
KNGDGEVQNYVGIFSDITQSKKNEVRLEQIAHFDPLTKLPNKFFVLEKLSKFMKEAKANNKKLGLVYFDLDGFKQANDTYGHNISDAVLIKVSSRIKDVL
-KENLLARFGGDEFVALIKDIDDENLKTIFDDILNSVNDDIIINDMNIKVGVSIGATLYPQEKINISGLVKQADWAMYKAKYSGKNRFYIFDEEKDSLF-
DYYNQMILSNDEFSHDEFILMYQPVVNTKDKKIISFEALIRWKHPQKGIVLPLDFLHVLKHKKWITDFSIWVIKFALSTIKDLGLKH---TNISVNIPLK
QLRDPLFFDKFKKLCSEYGAICHLLEIEVTDVPLSTSTT--FDGIFKYKDLGINLVFDDFGLDTAFIKTMKYIQADIYKINKDYALEILEDSANIEVLQN
IYSVCKAFGKTPVIKGVSDERIYKIVSSIGFDNIQGNLISEPMREDEILPFM--------
>tr|D3SEK0|D3SEK0_THISK Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Thioalkalivibrio sp. (strain K90mix) GN=TK90_0530 PE=4 
---------------------------------------------------------------------RETQERVRESEHRFRDLVHQAPMAIEVLTPD
GGVRQVNTAWETMHGHAGVKGMN-------VLHHPDPIDGVTEDIRAAA-RGAPFACHDPAKAPAG-SRWVKGYVYPLKNHRGEVRDIIVMQEDITLARR
GEDALRVIASFFQNLVLRL------REVFRADYALAGI--NVPDL--PGHVE---------------TAALCRDGELVGNIRYALASTELFPRSYLGAPM
IDSQGRELGHIAIVNRYLERLEGEEHIRRLAYHDPLTGLANRTQLHDALTQDLDLAHHGGQHGGLILIDLDHFKTINDALGHAVGDTVLAAVADRLRQHA
PEQALVVRLGGDEFATLIHPRRARQVNDAAHRLLDALQHPIVLGERTFSVGASLGCVLFPDAGQTSSDALRHADIALYQAKRAGRGGVQFYRHALQDEAR
ARLQIEEGLRQALVNREMRLSYQPQFDAQ-ENMIGAEALLRWTHPELGPVGPALFIPIAEETGLIHPIGTWVVEHVLENLQDWHARGLPLPRVAINISPW
QLARPDFVAQLRERVQAAGLEAGQITLEVTESGLLRDLSDAIGKLRALREFGVQVALDDFGTGYSSLAYLRDLPLDELKIDKSFIDELVDK-GEQMLIEN
ILDIGHNMGLRVVAEGVAKPAQRQQLLALGCTHFQGFLYGQPIAEDEFPAWLERNAT---
>tr|D0L1D4|D0L1D4_HALNC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halothiobacillus neapolitanus (strain ATCC 23641 / c2) GN=Hneap
---------------------------------------------------------------------INKNHRLQSSEKRFRTLIEQSSFGIQLVSVH
GNIELTNPAWQKMRGLIANDFD----------QGPISRDHLMPFIHRGF-AGPPLRWENAEYHSNA-TRWIQTKIGPIRDENGSVSHIILVHEDVTEEQQ
VETAIHKIAQFFQQMVVSL------VELFHVDAAFIGA--LDETD--PQKLT---------------TLALYSGGTLQENLRNYPFDAAVCPVHYRCAML
CDNKNEPTGLLVLLNRSVQQIKADQHIRQLAYEDYLTGLSNRALFHQRLSQTLAEARSSMHLGALLLIDLDHFKTINDALGHDVGDDVLKAVAIRTKEAT
DEKTLLARFGGDEFVALMLLDTTIDASKTAKHILDALKAPLSVNGRDFSVGASIGVVVFPQENETELDILRHADMALYKAKKHGRNNVQLFNPSLQIAAT
TRLKLEEGLRAAVGNNELSLNYQPQVNID-GCCIGVEALLRWHHPELGVVSPDEFIPIAEETGLIHPIGLWVLEQACKDLSRWHENGIPFGHMAVNVSPW
QLISTNFVNEIKQIVEQYPLDPKRIMLEVTESTLLHNRYESIAKLEQLRHLGFKISLDDFGTGYSSLSYLKDIPLDQLKIDKSFIDELEKTDDEQPLLAS
IYAIGIHMHLAIIAEGVETQNQCERLISMGGKAFQGYLFSKPLTELDLIAWLRGTQR---
>tr|C5BT20|C5BT20_TERTT Ggdef domain/eal domain protein OS=Teredinibacter turnerae (strain ATCC 39867 / T7901) GN=TERTU_3871 PE=4 SV=1
---------------------------------------------------------------------RSASEVLKVNQQRLSQVVALSPHSIQLVDTN
GKLLQQNRTAGQLWGHTLQLGDN-------LFTLAPWRE-VASVINRGE-ML----VLESFRECDH-NRWVRFKIFPVVGRLGRRDSVTLIAEDITREQS
VENTLKTLADFFELICAQV------QQMFHAKCVFLAQ--YNPDDD-GGSFE---------------TLAANLGGKPMEDFSLAAHTGARYPASFMGIPL
YDDLAQVIGCMAILNDRMQRLDAESRVRRMAYEDYVTRLPNRASLHEHLAKVVRDCAANDWGATAFFLDLDHFKTINEALGHDVGDEVLRLVGLRLRDHF
ADSCFVARAGGDEFVLVQTSQSSISIDVQANKVINLLSKPIMLGERTISIGTSVGVIMIPKHGNTILDIMRRGDSALFKAKQAGRNCYAVYDPRMQKSIE
ERMQVEKGLRIALEQNQFGIFYQPKVDAS-GRVVGAEGLVRWSHPEHGFISPSVFIPVAEETGLIHLIGEWIMEAIAGDLVRWQDMKIEPGDIAINISAW
QFGRADFIEKTLAGIRLNNIRVEQLSIEVTETAILGDMGTTRVKLNQLRNAGISVMLDDFGTGYSSLAYLKDLPLDGFKIDRTFVEGLGDA-QAEPLVRS
MLSIGKHMRLKVVAEGVESKEQFDKLKAMGCKLFQGYLFAKPMPVDEFLMWVKNNLE---
>tr|I1YJL9|I1YJL9_METFJ Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Methylophaga frappieri (strain ATCC BAA-2434 / DSM 25690 / JAM7) GN=Q7C_1972 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------------TVLHARDGQRYHISDSAAPIRAPESAILGVILVFQNVSQQYQ
LRQDLRHSVTILRVSPSVTYVLDVRGTLSYVTESVTAMTGKPAEFWL-SHPQAWISRIHPEDVQLTLHKVLQSDTPLTNQFRFQHVDGHYIHVHLFATPE
TSDDGH-QQIVGVVLDVSHQQKAEQKISFLAHHDVLTKLPNRALLSDRIMQAMSVCERYHQCLALLYLDLDRFKFINDSLGHAVGDQLLIAVADRLKKLM
RDQDTVCRTGGDEFIILLPDTDADGAAHVADKLIDKLTAHFDIENNQLFITVSVGISIYPENGRDADTLNKHADTAMYRAKQAGRNQYQFFTQEMHAQIA
HKMELEHALRFALSQNQLNLVFQPQIEVKTGRIMGAEALLRWQHPQLGQISPQTFIPIAEETGLINTIGNWTLHQAISQCRQWLDSGHQEVQVAVNLSAV
QFNNPTLVSTIETILAEYHLPAQYLELEITESVAMINIELTIKQLESLAALGIRLSLDDFGTGYSSLNYLKKFPIDTLKIDQGFVFDMLEDEDDAAIVDA
VITLARSLGLNTLAEGVETQAHADALQIKGCDFMQGYYFSKPIEAAAFTVLLDQ------
>tr|Q1K1L5|Q1K1L5_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_1837 PE=4 SV=1
-----------------------------------------------------------------------------QQEKRFSDMIEHSGLVVIGIDHT
SSIILFNQAAEKATGYAREDVLQEN--FFGLFTSPATAEHLGGYIAKAMAHGFTGDFHAPLKMRDGRVRQFLWDAIFEYDENGQIDNFIGFGRDVTEALA
AERRLKLITKVFENTAEAIIVTDRCNQIIEVNQAFISISGYSRGEVLGQNPRLLQSDHHDGAFFAQMWKQLIDTGHWEGEVWNRRKNGEEYVSWVTIDTI
RDHDGSIKNFFSISSDISQIKEAERQLHQLAYFDTLTGLPNRVSFAQKLEEHLTTCDEA-CNLAVMVLDLNAFKLINESLGPVLADKLLQMFSERLTLCS
YDDSFVARIGGDEFAFILRK---QRVRSLLDELFECVEAPFVIGAQRVSLTTSVGIAVAPDDGETVSELLKNANIALYSIKDIRRNSFSYYEQVMSDRVI
ERMSLAEMLREAVDNGEFELYYQPKINLKDGMVVGAEALLRWH-SRDGMVPPDRFIPIAEQTGLILPIGEWVLLQACEQAHIWRQEY-PEFHMGVNLSPA
QFDLDYLPRLVADILKEAQLPAEALELEITEGMIIEDIDNTVQILRSLRDLGVEISIDDFGTGYSSLSYLTRLPLDILKIDRSFMFEVPDSRDSTNVVLS
ILALARSLNLKVTAEGVETEDHVTLLHDHRCTYIQGYFCSRPLPVAEFEEFMRH------
>tr|K6XMZ2|K6XMZ2_9ALTE Uncharacterized protein OS=Glaciecola arctica BSs20135 GN=GARC_5084 PE=4 SV=1
--------------------------------------------------------------------IQNRELLLRNSEERLGMALWGSGEGLWEYRLL
NGSIFLDNMSCRILGLSNSEITTDF-TVFSRSIHGDDRARVEKYFSDANHPNELFEVEFRV-AKQKSYTWLQLRGKLVDSSDINNQTVLGTFRNITENIE
SEEQIRLYAKAFDSSSSAILILDKRLIVLAANGSFSQITGFTLSDIVGRVPDFINSDK-STFNISDFTHNIDAYGKWQKELIGIKSDNSHYVQDISINVI
LDSEKFPSHYVCAFSDITQKKKSEEDLWELANHDILTGLPNRGYFRKTLEKTLNKATRTNESIVLLFIDLDRFKQVNDTLGHETGDELLIKVARILSKVA
RRNDYAARLGGDEFAIILEGITEKHIDRIAENLVLKFNSGILVDDKDTGVGISIGISVFPTDTTNSDDLIHFADTAMYYSKIHGTNQYHFFNASMSDHVN
RRNLLENELRAALQNGTLSLYFQPQINIGSGEIVCFEALSRWFHPELGTITPDEFIPIAEDAGLIVQLGQQVLINACKQLKVWHNQGFDELRVAVNVSAK
QFLLSDVAFDVTNVLQEYNLDAKHIELELTESLIVDDPDKIIGVLNQLKKLGVKLSIDDFGTGYSSLSYLSRFPLDVLKIDKSFINQLTTDKKGIAITQA
IIAIAHSLKLEVIAEGVENEEQLEILQRLNCKYVQGYYFSKPISANDTIAFLKN------
>tr|A4C4P9|A4C4P9_9GAMM Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudoalteromonas tunicata D2 GN=PTD2_03141 PE=4 SV=1
---------------------------------------------------------------------------------------QLAQLGWWRLDPT
DNTVFWSKEWHKILSMSAKATASHQ--AFMDLIIDEDAEQISVAFDTLFQQHQSFNLEHRVRLATGEEIWLHHVAQVSHHEDG--YFFIGTIQDITLRKR
NNQQLELVLRVFENMNEAVLITDGQQKIVKINRAFTDITGYELSDLHGSTPSILNSGRQNAEFYEKMWASIQEQGHWHGEMWNRRKNGEVFPEWLKIATI
CDENNKVLYYYSIFSDISEKKRTQELMRFQANFDHLTGLPNRTLVFERLTNSVKLAKRANQEMAVLYIDLDMFKLINDSKGHLVGDELIKQVADRFKSVI
RSSDILARVGGDEFVIIANAITPYSAELVADKLQAVLKVPFMIGNERLHTSSSLGIALYPFDGIEAGTLLLKSEQAMYQAKELGRQKSHFYTDTMQQAAK
RRQLVKEAMLYGLEQDEFYVQLQPIVCVASNKVTKYESLARWNSKTLGQVAPIEFIAAAEYFGLIDQIGFLVAQKALIAIEKINTATHQVAQVAINRSIK
EFSSTQ-VMPLSELIKQSNVPPSWVILELTESVLMIEQLTNNHEIFLLRDMGVKIAIDDFGTGYSSLSYLSKFPVDMLKIDRSFIANIETDPSARRLIDT
ILKLAEGLDLETVIEGIETQAQLDFISELGATYYQGYYFSKPKRVA--------------
>tr|A0A0A0BUE4|A0A0A0BUE4_9CELL Uncharacterized protein OS=Cellulomonas carbonis T26 GN=N868_16175 PE=4 SV=1
----------------------------------------------------------------------------------VLNLLGSDEEVVYVKDRE
SRYLRASLGCARQHGRTPEEMVGLD---DFDLYAEAYAAASYDDEQRVMRTGPIVQQKVRERWHDRPDSWVSVSTFPLRDAAGEVVGVYGISRDITSLVR
AEQEMAAAEAVLDASTDAIAKYDRELRYQYINPAGEQSRGTSLEELIGRTDREI--GMGDT-SL-ALWEEVLRTGEPD-EIEFPTDDGAEAWFHTTVSPD
RDSTGAVVGVLTSTRDITATKQAEAALAHQAMHDSVTGLANRYLLMDRLGRAVRRTGRRGARLALCFVDVDHFKEINDTYGHDVGDRVLTELSARLTSVT
RPRDLVARLGGDEFVILREGVTEDDVRRLAETVVRVLAEPVVDGPLSLRVSASVGVVLSADPRTTASELLRDADAAMYRAKEGGRNRFRVS-GDDAEGEV
SSATLVADLRRALDDGEFRLVYQPLLSLVDQQVLGFEALLRWDHPERGTLGPRDFIAFAERRGLMAGIGGWVLRAACAQLARWRRDDADPLTIAVNVTVR
QLRADGFVEQVAAVLAENDLLPSQLRLEVPERALLNEGAELADVLSALDGIGVQLAVDDFGSSFAALALLPRIPVSVVKLGRFA-----ELADHPDLAAA
VIEVAHGLGMSVVGAGIESSVQLRRLHALACDDGQGFLLGRPLDLPDVERLLAA------
>tr|C7Q6I3|C7Q6I3_CATAD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Catenulispora acidiphila (strain DSM 44928 / NRRL B-24433 / NBR
----------------------------------------------------------------------------------LYNLLSACADTIFFKDRE
SRFIRVSRSQADLTAESPTEMIGKT---DFDYFTSAHAGNAFQDEQKIIRTGPMFDIREANTLPDASERVFSCSKQPLRDFDGMIIGTFGISRDITARTT
TEAQL-AAEALIESSPDPMCRFDRQLRYTYANPAALRVAGVPESELVGRTNREA--GHQEK-FV-REWEQVLRTGVGD-EVEHV-LAGTRRFFHTRLVPE
RDATGTVVSVLTVSHDLTDRKRIEDALAEQAVRDPLTHLANRALLVDRIDQALAKMRVQGGRLAVLFLDLDRFKVVNDSLGHAAGDALLVATAARLRSAR
QGSDLVARFGGDEFVILCEHVQGKDAADVARRVTRALSAPFERDGQPIHISASIGIAVTSDPMTTADELLRDADAAMFRVKARNHGSYIFFDDSVREEAV
SRLWLEGELRRAIEEKEFRLVYEPVYNLRDRQIIGMEALIRWQHPERGLLPPSTFIEIAEDCDLIVPIGRWVLHEACGQLAVWNRRGKPPLTMAVNLSPR
QLNDEGLVAEVANALRGSGLEPEQLTLEVTETAVHEAPQFAQAVLSQVSDLGVQIALDDFGTGYSSLGHLRRIPANALKIDRAFVNGLEHKGGDTAIVTA
VVTMAHALGMITVGEGIESEAQYEYLRALGCDQGQGYLFAEPVSAAAFETLHL-------
>tr|A4A7F0|A4A7F0_9GAMM PAS domain protein S-box/diguanylate cyclase (GGDEF) domain protein OS=Congregibacter litoralis KT71 GN=KT71_03192 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------YTHRDGRRGWVDNRKYPILDQEGRLLGLYGVARDVSTEID
AQRRQALVTSVFANAAESIVILNGNHEIVDANKTFESFTGLSREEVLGKSLKAAKHARDDSGEFEALWDTLLREGSCSGEVTTFDARGHKRSELCRITAV
IDDQGEAHHFVCLYSDITPLKEHERELETIAHFDPLTGLVNRSLFEDRLYQAVATSERQGTFLALAYIDLDGFKLVNDSFGHAVGDRYLIAIADNMNEAL
RDTDTLARIGGDEFIALISDLDDEGFAPVVERLLQATSKPVMLEGQEIPVSASIGIARFPLDGLEPGSLVRCADQAMYEAKRQGKNRFYVFDRGLVGNEG
AS----GDVRRALADEEFELFYQPKVNMLTGELLGVEALARWRHPHRGLLQPPEFLPLIDRENLQIEFGEWVLSEAVEQIRQWRGQEIA-TQVSVNIAGV
HLLQSNFLESLGSAIARYPLLAKTLEIEILETSALNDVARVAKIIEYAHAFGVSFALDDFGTGFSSLTHLRRLPVSTVKIDTSFVRDMLESSEDTAIVSA
MVGLCRGLGRQVIAEGVSTPAHAQALVNMACNFGQGYAIAAPMPAKALAGWI--------
>tr|B8KKA6|B8KKA6_9GAMM Putative uncharacterized protein OS=gamma proteobacterium NOR5-3 GN=NOR53_2979 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------YRHRDGKQGWVDNRKYPILDERGALIGLYGVARDISTEIQ
YLQRQSLSASVFEHAAESIVILDAAQTIIDVNRSFETSTALKKSDVQGQSLQAVKHRLDSSAQFEALWNTVLQSGSYEGEVESIHADGTKHVELCRINAV
LNEQEQAHHFVCLYSDITRLKHHEQELESIANFDTLTGLVNRQLFEDRLEQSLANCERRGNHLALAYIDIDSFKHINDSYGHTAGDDYLIGIANNMQLAL
RDTDTLARIGGDEFIALITDLERDDLEPVTQRLLEAATLPVMVNDRQLTGSASIGIARYPLDGEDAGRLIRCADQAMYEAKQQGKRRLHVFDRGLLRVSA
SR----DNVEAALDSGEFELLYQPKINLISGELVGFEALARWNHPQRGLLQPAEFLPLIDRENLQLEFGDWVLDQAVKQIESGLQSNIS-LPISVNIAGV
HLRQTDFVESIASKMQAVGMGPQLLEIEILETSALDDLSAVAGIISSANALGISFSLDDFGTGFSSLTHLRRLPVSTVKIDTSFVRDMLESEEDFAIVSS
IVSLCRGLNRRVVAEGVSSVAHAKALIGINCIYGQGFGIARPMRRQELSHWI--------
>tr|F5R966|F5R966_METUF Putative Diguanylate cyclase OS=Methyloversatilis universalis (strain ATCC BAA-1314 / JCM 13912 / FAM5) GN=METUNv1_00686 PE=4 SV=1
----------------------------------------------------------------------RNEHILQLTQERLELAIRGSNDGIWDWDLL
SNHVYYSPRWKQMLGYADHELDNRPD-TFLDRVHPDELPLLDRI-NDYLENRPAFELIIRARHRDGSWRWILTRGLAVRGRDGRALRMSGTHTDITALKQ
AEAGLALERVTLLSIGDAVISTDASGRIDFLNPAAEALTGWRNEDTTGRRLSVLQPGRPRPDLVE----TRLEAGAAPGESVIVARDGQERVVEHASSPI
RDAVGDISGTVVVLHDATDRYRMQERLRWQATHDPLTGLANRVLLEDRLTQAMARARRQDRMLAVCVLDLDDFKAVNDRLGHEAGDELLQEIARRLEHSV
RADDTVARLGGDEFVVLLGALKDDEMDSCLQRMLEALAAPVAISGEEVVTPASIGVTLYPLNDSDADALLRHADQAMYEAKQSGGRCYRLFDFLNSQVSV
ERLRQRERIGEAISRGEMRLHYQPRVDMREGRMMGVEALVRWQHPEDGLLPPDRFLPLIEHDPEIHRLGEWVIRTALAQLAAWRAEGGR-FGVSVNISAP
HLLSPGFVTRLSELLAEQPLPRQALEIEVVESVALDDIERAAAVVRDIRRLGVRVAIDDFGVGYASLGYLRRLPVDVVKIDKSFVLDMLEDEDDFEVVQA
VIALAQALRREVVAEGVETAEHGLMLQRLGCSQIQGYGIARPLPADALMPWLAA------
>tr|F9U6T8|F9U6T8_9GAMM Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_0640 PE=4 SV=1
------------------------------------------------------------------------LERLEKSEWLLKESQQVAHLGSWSLDIA
TGAVTWSEEVYRIFERDPQTFDTTF-ESYLAAVHPDDRAEVQRLYRQSVERRETLDILHRIALPGGGLKWAEVRGRTEYAADGQPQRSIGTVIDITEQQQ
ARLALNRATMVFANTVEGIMITDADNRIVAVNPAFSTITGYAEEEVIGRLPSLLQSGRHDAAFYRDMWKRLSETGHWQGEIWNRHKNGDVYPEWLALSLI
RDETGKVQKYFAVFSEISEHYRNQERIEALTYYDQLTGLPNQKMLRLRLEQALLSAMAAGESLMVLSLKLHEFKHVIASFGHTAADAALVACAERLRKVL
PTDAILARPGGDNFIVAQQCGEDDAASKQATALQNALREEARVAGIGAGMSSCVGISLAPTDAEDADVLVRYAGVALEMARQTGPGSVTFYQPEMAAAAK
RRVELEHALRKALAEDAFELYYQPKLDLRSGQMCGAEALIRWRQADGTVVLPAEFMPVVETTDLVHQVGRWVIESAAKAIADWRGQGLSPGSVSVNISSA
TLSAGLLASALEDAIDANGIDPRRLEVEVLENIMLQDPTQAKAELLRARQLGVRIALDDFGTGYSSLRYLKQFPFDTIKIDRCFIMDLKPSSDDTAIVRS
TLSMAQQLGLEVVAEGVSSDDQLRLLQSLGCEKAQGYLIARPMPATAFTDLLRD------
>tr|C6BSB1|C6BSB1_DESAD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8
------------------------------------------------------------------------ARSLVKSEKRYRALVETTAEGFFMIDES
SILLDVNPAFCTMIGLTREEVLGGD---IGAILGDTAAE-RF-----RNNEGHSHKFELSFVNSNGREVDIFINATNLFE-SDNVKLTFAFVTDVSGYKM
MEKALRASETIAEYTFDWEMWIGPTGAVKYVSPSCERISGYPKAYFMEGPVRILH--KNDR----EFWQKALRGTSADGDMRLFRRDGLLRWVSLTGHQV
FADDGTSLGLRISLRDITKRKFMEKQLQYEALHDPLTGLANRTLCCDRILQAVERSRRRDYYFAVVFMDLDRFKIINDSLGHNIGDKLLVEVSKRLLQTI
RELDTVSRFGGDEFIVVLEELASREGIRIVRRIRDCLNDPIMIEGHKINIAASYGVLLSPTEYDKPEEIIQNANVAMHQAKESGRDRIKVFNKRMLEEAV
QAMQLESDLRAAMLGDELYLDYQPIYSLQSQSVVGFEALIRWEHPRRGLVMPGEFIPMAEESGLIFELGSWVVSEACRQMKSWQVNYDSAMMMSINISPR
QFSQPALVDNILSKLSEFDLPARNLKIEITETAIMERAKQSVDMLNRLKSAGVLVSIDDFGTGYSSMSNLQEFPLDQLKIDLSFVRKMNESTENLEIVRA
IVNLAHNLGLNVVAEGVEEIEQQDALRDLGCEFGQGYLFSKPISRSKVEAFFK-------
>tr|L0R5V5|L0R5V5_9DELT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfovibrio hydrothermalis AM13 = DSM 14728 GN=DESAM_10087 PE
------------------------------------------------------------------------AKSLIKSEKRYRALVETTSEGFFMIDDN
QVLLDVNPAFCRMIGLAREDVLGAG---VASILGEVAAA-RF-----SDRQSGDYRFELSFENNEGREIDIFINATHLYE-SDLDTLTFAFITDISSYKL
MEKALRGSETIAEYTFDWEMWIGPTGSVKYVSPSCERISGYPKAYFMEGPMRILH--KNDR----EYWQSAMSGNSVDGDMRLFRRDGLLRWVSLTGHQV
NADDGTSLGLRISLRDITKRKFMEKQLQYEALHDPLTGLANRTLCCDRIRQAVERSRRRDYFYAVVFMDLDRFKIINDSLGHNIGDKLLVEVSKRLLQSV
RELDTVSRFGGDEFIVVLEESASREGVRIVRRIRDNLRVPMMIDGHKINVAASYGILLSPTNYDKPEEIIQNANVAMHQAKEAGRDRIKVFNKRMLDQAV
KAMQLESDLRAAMASDELFLDYQPIYSIENNETVGFEALIRWNHPRRGLVMPGEFIPMAEESGLIFELGSWVITEACRQMKSWLDRYDNAMMMSINISGR
QFSQPTLVDNILSNLMDFDLPPHNIKVEITETAIMERAQQAVEMLQRLKTAGVLVSIDDFGTGYSSMSNLQEFPLDQLKIDLSFVRKMRDSVENVEIVKA
IVNLAHNLGLNVVAEGVEYMEQQELLKDMGCEFGQGYLYSRPMSVENVEALFK-------
>tr|Q2BQ13|Q2BQ13_NEPCE Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) withPAS/PAC sensor OS=Neptuniibacter caesariensis GN=MED92_06353 PE=4 SV=1
------------------------------------------------------------------------------QQRFIQSVTDSATDLIFICQRN
T-ISRANHSFPSLLGQPIDSFISQIHALFSTEHKPNGQS----FLNLSL--NQEQDLE---LTIEGTKRYFSLNTQTIPG---DQKQYVLRLVDITERKQ
VEQTLQLSASVFTHAREGILITERDGTIVDVNDALLQITGYKKEEVIGQKPSLFSSGHHGKEFYHSLWNDITEKGYWSGELWNKRKNGDIYAQMLTISSV
KDGENE-GYFVALLSDITTIKEQQKKLELIANFDPLTGLPNRRHIIELLHEGMANAMKQMKTLAVFYLDLDGFKDINDTYGHEYGDQLLVTLANRMSKAM
GQQDIVGRVGGDEFIGAFEEPNS-VFTDKLHHILEQLAKPIFVEGYKLQVSASIGVTLYPQQSTDADKLVREADQAMYQAKLAGKNRYHFFDAEKDQYIR
GQHQALEDIRRALERGEFVLHYQPKVNMFTGQICGAEALIRWQHPEEGLIMPGDFIPTISAHPLSVDLDEWVILTALKQIELWLHSGFD-IPVSVNISPL
QLQDSEFSKRLEKLLHTVSPARTRLSIEVIESHALENMSTALNAIEESKALGISFSLDDFGTGYSSMSYLKRLPVEELKVDRSFVHGMLNNQEDLAILSA
TIGLAKAFDKKILVEGVESEEQGQRLLSLGYQEAQGYFISKPISADQFIEWQA-------
>tr|H8Z8I4|H8Z8I4_9GAMM PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiorhodovibrio sp. 970 GN=Thi970DRAFT_04907 PE=4 SV=1
------------------------------------------------------------------------RKQLEERDALLRKLSSNVPGFIYQLHPD
GHFPYASDGIERIYGVLPEQVLETA-QPVLDVIHTGDIDRLIAGIQDSARDLSFWQDRYRVQIPGRALGWRDAQAKPERLADGSVL-WHGYIWDSSERVG
AEERQRLAGRVFASAREGILITDCRGRVVSLNPTFTELTGWRESQMSRRGLRRLKTDRHPRTLYRSLHRSLTSKGHWKGELWVARDRREPFPALVAASEV
RDDDDAVTHYVFLFDDISHIKEQQRRLEYLAHHDAVTQLPNRVLFADRLEQAMARTRRNGGLLLVAYLDLDEFKQVNDSRGDKIGDCLLVEVARRLASLV
RDDDTVARIGGDEFALVLNEQDDNACRECMSRLREALARPYLSSAKAVHISASIGGTLFRGEPVTGDELVRQADQAMYRAKELGRNRVELFEHGRVRAHS
DRENSLTRIERALDQQEFVLYYQPKVDMHVGRVVGVEALIRWQHPQRGLVPPGDFLPVIEGSEFTVPLGDWVLESALKQLETWHAAGLH-LGVSVNISPT
HLQAPGFAEHLGEHLARHRIPPQCLELEILESTALDDVGYVSAVITDCHDYGVRFALDDFGTGFSSLAYLKGVPADVLKIDQSFVRDMLTDRSDLAIVEA
VISLGRSFGKQVIAEGVETPEHGLALLHAGCQLAQGYGIARPMPAAAVADWV--------
>tr|K4KPW4|K4KPW4_SIMAS PAS/PAC and GAF sensor-containing diguanylate cyclase/phosphodiesterase OS=Simiduia agarivorans (strain DSM 21679 / JCM 13881 / BCRC 17597 / SA1) GN=M5M_15815 PE=4 SV=1
----------------------------------------------------------------------KIERQIADSEATFRKLANAMPQHVWITQPD
GELGYANERCLDFFKLSFDQLRE---QWF-DQIHPDDQNHIEQWLH-ATNSGEDYSCQFRLKPANGDYIWFISRAIPVEDELGNVVAWYGTNTDVSESMA
AQQAVEQQAAIIDGVMDAIITINEQGLISQFNTAAEALFGYSEKEVLGKNVNLLVPDPHHHQYIQNYLNIIGKGGVVDGEIWHRHNNDKLAPDLIASVLL
LDACGTAVYYQKICSDITH-DRRETRIKQLAFYDSLTRLPNRALGMDRLSRAISDAQRRSESLAVMFIDLDGFKTINDSLGHHVGDRLLKLAAARLDKCV
RENDTVARLGGDEFIVILHGPKDSLADVVAQKVLEAMTRKFQIDEHALHVSCSIGVALYPRDGADAQSLLRNADAAMYRAKELGRNNAQYYTEELNRAAM
ERITLESEIRAALERQEFYLHYQPRVNNRTGKIIGLEALVRWQHPSRGTLGPNVFIPVAEQSGLITALGEWVLNHACTQVNLWLNQLSTPLSISVNLSPR
QFRDPALTEKVAHILAQSALPPELLELEITESMVMDDAHDTTVQLHQLKSLGITLAIDDFGTGYSNLSRLKHLPVDVLKIDKSFVDGIPDDTDDTAIATT
IIAMGHHLNLKIVAEGVETFQQQKFLSENQCDEMQGYLFGKPVSTKDIEHILG-------
>tr|L8D9X8|L8D9X8_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudoalteromonas luteoviolacea B = ATCC 29581 GN=PALB_37370 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------QHGELIGVLGIGHDITDRHQ
TERQLNVAASVFHTAMEGIMITDLSGIIVDINDSFTRITGYTRSKAIGQNARILNSGKQSSSFYTSMWKKITQHGHWSGEIWNKRANGELFAEFLNISVV
YDNQQRPSHYIAVFSDISTLKEQEKQLAYVTRYDALTGLANRSLFLTQLRQQLLVLKQTKLFLAIIVVDLDEFRQVNDQFGSQIGDTILVQAAMRFKTLL
REHDLISRLGGDEFVILLNNLSGEHSISILERLLLSASKTFDIAGHAFNLSASIGVTFVDESELSAEKLVRQADNAMYQAKVAGKNRYHIFDPNDDLDTR
IRFEMLNEIRRALIHKEFYLVYQPKVNLRTGDLVGFEALIRWAHPTKNLLHPNDFIPIINMHPLAIELGNWVLDEVMQQVAKWNRIGFH-TVVSVNIDSL
QLDDPTFRERLLNKLKATSIKPEQIELEILETNALEQIENVSQLIDELQKQHITFALDDFGTGYSSMTFLKNLPVSTIKIDKSFVQQMLSDPEQFIIVES
IINLSKRFGRIVLAEGVESEFHGILLAALGCDIAQGFGIGKPMKVDHITKWLTQWRAP--
>tr|A0A0D8MXJ8|A0A0D8MXJ8_PHOLE C-di-GMP phosphodiesterase OS=Photobacterium leiognathi GN=UB34_05145 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SLAPLCDLEGNIQHIILHSIDTSERQI
LIHSLEETEQLNNLITEGICLIE-NNVVINANDQAAIQLGFPTKELLGRSLQLLLDSNNQPCTGERLKSDDSKSPA---CYTPINKNEQTKPVKLSISPV
K-QMGSEALLV-KIETTQEIKRQQGHIEQLVQMDPLTGLLNRHGFTRQLEQLMKA----EVPVVMLYIDIDNFKNINDSLGHHIGDKVLQEIAQRLRRLL
PETAIIGYLSGDEFAILLPNPEHRTGEIISEQIIALVNQPFELRHFRKHLACSIGMVTSPGHGSDARMMLQNADTAMYEAKHRGRNRLVEFNDSMSKEAR
MRLWLEIELQKALQNNGLEVWYQPKVNARDFAIDGAEALVRWKHPVEGYISPAQFIPVAESSGLIEQLGCVVMREVFTTVSQWKKRKLLTGRVAINLSPQ
QFGNSGLISFVDKLRLSTEINPADITFELTESAVMSDGEHTVQMLNSIKQLGFALSIDDFGTGYSSLSYLARFPLDELKVDRAFIQDIDTIPKQVTLIEN
IINLGKSLKMSVVAEGIETRQQATLLSNLNCDYIQGFHFYRPMPKHELEAILLQ------
>tr|Q6LUI4|Q6LUI4_PHOPR VV2690 protein OS=Photobacterium profundum GN=VV2690 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SLSPLRNKTGNVSHIVLHSVDTSERQI
LVNSLEELEQLNELISDGMCIVE-ADIIISANQVAANLLGFDDKELLGEELRLLIDSHSQRILGETLSQMPSGDPR---KCHTSPRCCTERPLLVTTSDI
T-LMGSPAKLV-KLQDAAEHMMQQGQVEQLVHTDPLTGLYNRHGFSRRLESLITN----ETPLVMLYLDIDNFKNINDSLGHHIGDRVLQEISQRLRRLL
PENAIIGHLGGDEFGIVLSEPEHRAGDLVAQQVISLINQPFDLHHFSKHLACSIGMVSYPGNGNDARILLQNADTAMYEAKNRGRNRLVKFNEAMNKEAR
MRLWLEIELQKVLQNNGLEVWYQPKVNARDFAIDGAEALVRWKHPIEGYISPAQFIPVAENSGLIEQLGLVVMREVFTTVRRWKQQGILSGRVAINLSPQ
QFGNPNLIDFVKKLLKSTGVNATDITFELTESAVMSDGEHTIQMLNAIKKLGFALSIDDFGTGYSSLSYLARFPLDELKIDRAFINDIDTVPKQVTLIEN
IINLGKALNMSIVAEGVETRQQATLLSNLNCDYIQGFHFYRPLPKNELEAILVK------
>tr|A0A0D8NTW4|A0A0D8NTW4_9GAMM C-di-GMP phosphodiesterase OS=Photobacterium kishitanii GN=UB40_10525 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SLAPLTNVDGKIDHIILHSVDTSERHV
LINSLQESEQLQNLMTDGICVIE-KNIIMNANQRAVELLGMTSNALLGQALHVLLDNKKQPCHSKTFAQATHNNNR---HYYSAH-NDAHSPLMVTTTAI
T-MMGEAALLI-KLTPDTSTDEQQHKIEQLTQLDPLTGLYNRYGFSRQLELLMKA----NTPLFMLYIDIDNFKNINDSLGHHIGDKVLQEIALRLQQLL
PKNALIGHLSGDEFAVLLAHPEHNSGEIIAEQIIALVNQPFDLRYFSKHLACSIGMVKSPGNGHDARMMLQNADTAMYEAKNRGRNRLVVFSDAMSKEAR
MRLWLEIELQKALQNNGLEVWYQPKVNAKNFEIDGAEALVRWKHPVEGYISPAQFIPVAERSGLIEQLGRVVMREVFTTVKQWKKQQLLKGRVAINLSSQ
QFENPKLISFVDKLRQSTGINAADFTFELTESSVMSDGEHTIQMLNAIKQQGFALSIDDFGTGYSSLSYLARFPLDELKIDRAFIKDIDTIPRQITLIEN
IINLGKSLNMSVVAEGIETRQQATLLSNLNCDYIQGFHFHRPMPKQELEDLLLK------
>tr|A0A0D8P6N3|A0A0D8P6N3_9GAMM C-di-GMP phosphodiesterase OS=Photobacterium iliopiscarium GN=UB38_03710 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SLAPLTNAQGEINHIISHSIDTSERHI
LINSLQESEQLQNLMTDGICIVE-KNIINNANQHAVDLLGITSSALLGQSLRLLLDSNNHPCHSNTFTQAFHDNKQ---HYYAIN-HIERAPLTIATTPI
T-ILGKPALLI-KLTPVLCTNEQQHKIEQLTQRDPLTGLFNRHGFSRQLDQLMKA----STPLFMLYIDIDNFKSINDSLGHHIGDKVLQEIAQRLQQLL
PENTVIGHLSGDEFAVVLTNPEHNSGELIAEQIIALVNLPFDLRYFSKHLSCSIGMVKSPGNGHDARMMLQNADTAMYEAKNRGRNRLVIFSEAMSKEVR
MRLWLEIELQKALQHNGLEVWYQPKVNAKNFEIDGAEALVRWKHPVEGYISPAQFIPIAERSGLIEQLGRVVMREVFTTVNHWKKQQLLKGRVAINLSSQ
QFENPNLINFVDKLRQSTGINADDFTFELTESAVMSDGEHTIQMLNAIKKQGFALSIDDFGTGYSSLSYLARFPLDELKIDRAFIKDIDTIPKQIILIEN
IINIGKSLNMSVVAEGIETHQQATLLSNLNCDYIQGFHFHRPMPKQELEALLLK------
>tr|L8JCZ4|L8JCZ4_9GAMM Diguanylate cyclase OS=Photobacterium sp. AK15 GN=C942_00344 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SLAPLPDKSGDIAYIVLHSADTSERQV
LANSLQEMEQLNELLTDGSCIVE-GDIIISANQAAADLLGFESRELIGEELRLLIDSHSQRILGGHISQLGKTSPR---QCQTSPRCNTERMLQVTASDI
T-LLGSPAKLI-LMKDNSEQAAQQGQVEQLVHTDPLTGLYNRHGFSRRLSQLISQ----STPLVMLYLDLDNFKNINDSLGHHIGDRVLQEISQRLQRLL
PESAIIGHLSGDEFAIILPEPEHRAGELISQQIIALINQPFDLHHFSKHLACSIGMVNYPGDGNDARILLQNADTAMYEAKNRGRNRLVKFSEEMNKEAR
MQLWLEIELQKALQHNGLEVWYQPKVNARDFVIDGAEALVRWKHPVEGYISPAQFIPVAERSGMIEQLGQVVMKEVFTTVRKWKRQGLMAGRVAINLSPQ
QFGNPNLITYVEQLKKSTGVNPNDITFELTESAVMSDGEHAIQMLNAIKKQGFALSIDDFGTGYSSLSYLARFPLDELKIDRAFIKDIETLPKQVTLIEN
IINLGKSLNMSIVAEGVETRQQATLLSNLNCDYIQGFHFYRPQPKNELEAILLK------
>tr|A0A0B9G8F3|A0A0B9G8F3_9GAMM C-di-GMP phosphodiesterase OS=Photobacterium gaetbulicola GN=RJ45_04150 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SLSPLRNESDKITHIVLHCVDTSERQI
LTNAIQEHETLNKLMHDGSCIVE-NDTVISANDKAALLLGFEHNDLKGKAFKLIVDTQQQPVTSAQLASLQQGEGW---LCQTSRHCPQPQTLQLSTSPI
E-MLGAAAQLV-ILKSYAPARSKQSQVESSIHIDPLTGLLNRHGVSRQLEQLINQ----QIPLVMLYLDIDNFKNINDSLGHHIGDQVLQEISQRLKRLL
PDTAIIGHLSGDEFTILLPDPEHQQSSLIADQVIALINQPFDLHHFSKHLACSIGMVQYPGDGNDARILLQNADTAMYEAKNRGRNRAVKFSEEMNKEAR
MQLWLEIELQKALQNNGLEVWYQPKVHARDFSINGAEALVRWNHPVEGYISPAQFIPVAERSGLIEQLGQVVMREVFTTVRYWKTQGLLPGKVAINLSPQ
QFGNPNLIQFVDKLRKATGVNPNDITFELTESAVMSDGEHTIQMLNAIKKLGFSLSIDDFGTGYSSLSYLARFPLDELKIDRAFIKDIEEIPKQLTLIEN
IINLGKSLNMSVVAEGVETRQQATLLSNLDCHAIQGFHFYKPLPKNELEATLHK------
>tr|A0A066RVV8|A0A066RVV8_9GAMM C-di-GMP phosphodiesterase OS=Photobacterium halotolerans GN=EA58_08840 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SLSPLRNETAEITHVVLHAIDTSERLQ
LANAVAEREQLCQLMADGCLLIE-KNQILSANAVAAQLLGFSSEAIIGEDLQLLIDSRNNRPFGEQLAELSRGKTY---HCLTSPQCQTEHALTLTQGDI
Q-LVGSPASLV-VLKQPQKQQVHPDQVEQLIHTDPLTGLYNRHGFSRRLEQMISR----QIPLVMLYLDIDNFKNINDSLGHHIGDRVLQEISHRLRQLL
PENAVIGHLGGDEFGILLPEPVQDMGEQVSKKIIALVNQPFDLMHFSKHLACSIGMVNYPGNGSDARLLLQHADTAMYEAKNRGRNRLVTFDETMNKEAR
MRLWLEIELQKALQNKGLEVWYQPKVSARDFSIHGAEALVRWKHPIEGYISPAQFIPVAERSGLIEQLGKVVMREVFTTVKRWKKQGLLPGRVAINLSPQ
QFGNPNLIQYVSDLQRTTEVNPDDITFELTESAMMGENEHTIQMLNAIKKLGFALSIDDFGTGYSSLSYLARFPLDELKIDRAFIKDLETIPKQLTLIEN
IINLGKSLNMCVVAEGVETRQQAALLSNLNCDYIQGFHFFRPLPKNDLETILLK------
>tr|A0A0A5I7E3|A0A0A5I7E3_9VIBR C-di-GMP phosphodiesterase OS=Vibrio tubiashii GN=NM22_03820 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SVSPIET-EGKIEHVIFHALDTSEKQI
LIRSLEESETLTTLLSDGILLVE-DDCILSANPAALRLLGFDSQDVLGENLRLFVDEKTKTVFSESFCSMLSETPL---MCSTSPRCGLERKVQLQADAT
M-VLGGDSQLV-LIQDAEEAGGAPVNKNEDIHLDSLTGLYNRFGFTKRLEQLIHK----ETPLIMLYLDIDNFKNINDSLGHHIGDKVIKEVSSRLKRLL
PQHAVLGHLGGDEFGIILPEPENRMAEMLSERIISLINQPFDLHHFSKRLACSIGSVAYPGDGNDARILLQNADTAMYEAKDRGRNRLIKFNDQMNKEAR
MRLWLEIELQKALQQNGLEVWYQPKVNARDFSINGAEALIRWKHPVEGYISPGAFIPVAERAGLIEHLGRVVMRDVFSTVKRWKLQGILPGRVAINLSPE
QFGNPKLIDYMEKLLRTTELDPSCITFELTESAVMSDSEHTIQMLNAIKKLGFALSIDDFGTGYSSLSYLARFPIDELKIDRAFISDIDTLPKQITVIEN
IINLGKSLDLTVVAEGVETQQQATLLSNLNCNSIQGFHFYRPQPRQEVEELFAQ------
>tr|F9RAU5|F9RAU5_VIBSN PAS/GGDEF domain-containing protein OS=Vibrio sp. (strain N418) GN=VIBRN418_07080 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SISPISF-NNKVQYVVLHAIDTSEKSI
LIHSLEEAEALTQLLPEGLLLVE-HDCILSANPAAVRLLGFESSDLLGEELRLFIDENSKKSFNNKLGMLLHDAPI---LCLTGPRCGLERKVQLQAAHA
M-IMGEESQLV-LIQDAEQKKISDSTINSDAHIDSLTGLYNRFGFTKRLDQLIKN----ETPLIMLYLDIDNFKNINDSLGHHIGDKVIKEVSCRLKRLL
PQQAVLGHLGGDEFGLILPNPENRMVESLSDRIISLINQPFDLQHFSKRLACSIGSVVYPGDGNDARILLQNADTAMYEAKERGRNRLIKFNDQMNKEAR
MRLWLEIELQKALQQNGLEVWYQPKVNARDFSINGAEALVRWKHPVEGYISPGAFIPVAERAGLIEHLGRVVMREVFATVKRWKMQGILPGRVAINLSPE
QFGNPKLIDYMEKLLRSTELDPSCITFELTESAVMSDSEHTLQMLNAIKKLGFALSIDDFGTGYSSLAYLARFPLDELKIDRAFITEIDTLPKQVTVIEN
IINLGKSLNLTVVAEGVETQQQATLLSNLNCNSIQGFHFYRPQPKQDVEELFMQ------
>tr|A0A0C2NVA2|A0A0C2NVA2_9VIBR C-di-GMP phosphodiesterase OS=Vibrio sp. DCR 1-4-12 GN=PL18_05720 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SVAPIWL-NGQVQCIVFHAIDTSEKQL
LIRSLEESEALTQLQSEGLLVVE-NDCILSANPAAVRLLGFESHDLLGEDIRLFIDENSKTVFNNKISILLNESPI---TCLTGPRCGLERKVQLKATHA
M-VMGDESQLI-LIQDADKKIFTDTHSGEAAHLDSLTGINNRFGFTKRLDQLIKN----DTPLIMLYLDIDNFKNINDSLGHHIGDKVIKEVSTRLKRLL
PKQAVLGHLGGDEFGLILPNPDNQMAEILSERIISTINQPFDLHHFSKRLACSIGSVAYPGDGHDARILLQNADTAMYEAKERGRNRLIKFNDQMNKEAR
MRLWLEIELQKALQQNGLEVWYQPKVNARDFSINGAEALVRWKHPVEGYISPGAFIPVAEKAGLIENLGRVVMREVFTTVKRWKMQGILPGRVAINLSPE
QFVNPKLIDYMENLLHSIDLDPSCITFELTESAVMSDSEHTLQMLNAIKKLGFALSIDDFGTGYSSLAYLARFPLDELKIDRAFITELDTLPKQVTVIEN
IINLGKSLNLTVVAEGVETQQQATLLSNLNCNSIQGFHFYRPQPKQEVEELFMQ------
>tr|R1ILS0|R1ILS0_9GAMM Diguanylate cyclase/phosphodiesterase OS=Grimontia indica GN=D515_02761 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SVTPLTNSEWADGAVIFHAADTSERQV
LTSALESSENLCQLVGEGCCVLD-DGVVLSANQHAVKLLGFDSNEILGEDINLLVPPVKGQSVVASLTSLKSGQQL---VCQTKG-TGDSQTINVSYGSV
S-LLGGSGAII-TLSRTAAVTDHKQTIEKLAQFDALTGLYNRHGFSRRLEQLIKS----NTPLLMFYLDVDNFKNINDSLGHHIGDRVLQDIAQRLRKQL
PADTILGHLGGDEFAILLPEQSSEVAEELSQKVVDVISQPFDLYHFSKYLACSIGLVKFPGDGKDARSLLQNADTAMYEAKEQGRNRVVTYNQHMNKEAR
MRLWLEIELQKALQNNGLEVWYQPKVNAKDYTINGAEALVRWKHPVEGYISPGRFIPVAERSGMIELLGRNVMREVFQTVRRWQNMKVLPGRVAINLSPQ
QFRNPNLTSHMKKLQAATQTDPSLITFELTESAVMNDGEHAIQMLNAIKDLGFSLSIDDFGTGYSSLSYLAKFPLDEIKIDRAFICDMETFPKQVTLIEN
IINLGRSLNMSVVAEGVESGKQASVLANLKCDTIQGFHFYKPMPRAEFEALLNN------
>tr|D0I7Y3|D0I7Y3_GRIHO Putative c-di-GMP phosphodiesterase A-related protein OS=Grimontia hollisae CIP 101886 GN=VHA_001857 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------SVTPLAESEWREGAIIFHAADTSERQV
LTSALESSENLCQLVGDGCCVLA-DGVVLSANRVAGKLLGFDSNEILGEDINLLISPVKGQSVEASLNALKPGQQL---VCQARE-ADGNPALNVSFGSV
S-LLGGSGAII-TLSRTAAVPDHQQTFEKLAQFDALTGLYNRHGFSRRLVQLINS----NTPLLMFYLDIDNFKNINDSLGHHIGDRVLQDIAQRLRKRL
PPDTILGHLGGDEFAILLPEHSSEVANELSRRVVDIISQPFDLYHFSKYLACSIGMVRYPDDGKDARSLLQNADTAMYEAKERGRNRLVTYNQHMNKEAR
MRLWLEIELQKALQNNSLEVWYQPKVNAKDYTINGAEALVRWKHPVEGYISPGRFIPVAERSGMIELLGRNVMREVFQTVRRWQNMKILPGRVAINLSPQ
QFRNPNLTSHMKKLQAATEIAPSLITFELTESAVMNDGEHAIQMLNAIKDLGFALSIDDFGTGYSSLSYLAKFPLDEIKIDRAFISDMETFPKQVTLIEN
IITLGRSLNMSVVAEGVETGKQASVLANLKCDTIQGFHFYKPMPRAEFETLLIN------
>tr|C9P197|C9P197_VIBME Putative uncharacterized protein OS=Vibrio metschnikovii CIP 69.14 GN=VIB_000244 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------NITPLIQTPHHPDYIIVHALETSEQHR
LLHSLQESEALSALLNEGVFLIE-DDCILAANPSAARLLGFDEQDLLGETLSLFSDESNQSGFNHTLVQQLLINPI---HCFTHADYGPPKRVQLSAVRT
P-LFGSHVQLV-VMEDKSTTPISSSYPADEGYVDSLSGVYTRTGFIKRLDHLIEQ----HTPLIMLYLDIDNFKNINDSLGHHIGDNVIKEVAIRLKRLL
PAQAILGHLGGDEFALILPYPEHHSGEMLAERIINLINQPFDLHHFSKRLACSIGSVLYPGDGHNARVLLQNADTAMYEAKERGRNRLVQFDNQMNKEAR
MRLWLEIELQKALQQNGLEVWYQPKVNARDFSINGAEALVRWKHPIEGYISPGAFIPVAEKAGLIEHLGRVVIREVFTTVKRWEQQNLLPGNVAINISPE
QFANPQLIDYLTKLLRQTQLNPRYITFELTESAIMSGSEHTLQMLSAIKKLGFSLSIDDFGTGYSSLAYLARFPIDELKIDRSFISDMDNLPKQITVIES
IIKLGQSLNLTVVAEGVETQQQAILLSNLHCHTIQGFHFYRPQPKEEVEVLFSQ------
>tr|U3A315|U3A315_9VIBR Putative signaling protein OS=Vibrio azureus NBRC 104587 GN=VAZ01S_010_00240 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------TLTPIYE-EQAINAVFFHAIDTSEQQI
LSRSLEASEQLTQTLSDGVLLVK-EGIIVTANPSAARLLNVNTDELIGTAFPWFMDADSQKSFSHNLSHFLSSKPY---RCLTSPKHGQARRLQLQSNTL
I-SFGESARLI-LIQDEDHTPHNLPIFYRDADIDDFTKLLSRQGFAKKVDQLIED----KTPQLLLYLDIDNFKDINDSLGHLIGDSVIQEIAKRLKRML
PNQCIIGHLGADEFGVLLPNPETHSADILSQQLISLINQPFDLKHFTKRLTCSVGSVHYPQDGQNARILLQNADTAMHEAKKRGCNRLSQFNERMNKEAR
MRLWLEIELQKALQQNSLEVWYQPKVTTRDFSINGAEALVRWKHPVEGYISPSVFIPVAEQAGLIEQLGRIVMREVFANVKHWKHQGILPGRIAINLSAQ
QFQNPHLIDYVEKMIRTTEIDPSCITFELTESAVMSDSQHTLQMLNSIKKLGFALSIDDFGTGYSSLSYLARFPIDELKIDREFINDIDMSPKQVTVIEN
IINLGKSLNLNVVAEGVESHQQAALLSNLQCHSIQGFHFYRPQPKHDVETLFAQ------
>tr|D3FEJ9|D3FEJ9_CONWI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577) GN=Cwoe_1244 PE=4 SV=1
----------------------------------------------------------------------TAAVELAETESRYRTLVETIPAVTYVWDEL
GTLIYVSPQIEEMMGFPAAGWLGETSLWD-TQIHPDDVDRVMAETRYAFRQEQAFDCEYRLIAADGRIVWVWEHDTVIRDEHGRPRLTQGIITDVTATRI
AEAALAESEAVIGALEEGLLIYGADGRVLSCNAAAVRIFGVDSEELLGTSPRVRMTYEDGSE--------VTRTNSTAGEVHFRDDDGWELWATVTSHPL
REGESRPYGAVSAFTDVTERRRAQEQIAFLAYHDSLTRLPNRALLDEHLALALARARRAGESVALLYVDLDDFKAVNDSLGHAAGDELLKRIAVRLRAVV
RSSDLLARQGGDEFLILLTDLDKLSAEAAAKQVETALIEPFHLADAEFEVGASIGISIYPDDAADADTLMRHADAAMYEVKQAGRGGIASYGGD-SRKTL
ARLSLTSKLRRALQREDFVVHYQPIVAPATGALHAFEALVRWQDAERGVVGPNEFIPLAEDAGLIEAIGGWVLNEVCRQQRAWHDAGME-SHVHVNVSPR
QLRRPDFPSTVRDALEEQRLTPSMLTLEITESAAMLDAERANPIVRALHDLGVRLAIDDFGAGHSSLARLRDVPVQTLKIDQSFLRGVPDDRQAAAMITA
IIELGTALGMVTVAEGVTTDAQRRFLVDGDCPLAQGFHFARPLTADDATRLLRE------
>tr|Q8DIH6|Q8DIH6_THEEB Tlr1612 protein OS=Thermosynechococcus elongatus (strain BP-1) GN=tlr1612 PE=4 SV=1
--------------------------------------------------------------------RHLAEARLKEQQAQLELAARVSNIGFYFCDLH
TGTFYVSPSYKAQLGYPATTQEVNLEDWE-ERLHPEDRDRALAAYR-QFLRGAHYSIDLRLRHCNGTYRWFHSEAVLIHDEQGQPSKVVGTNVDITERKA
TELALRESELLAENTSDIICLLDCQGSCLYVSPSYETLLGWPTETLIGEHFTQLCHPEERSRVKQELQQMIEQRQFWPITYQVCTARGDVLWLETLVKPR
YDSQGHVQQLQTTSRDVTSRVQVQMQLHHDAYHDSLTGLPNRLYFMEQLAAAISQAQTNPQHYAVLFFDLDRFKVINDSLGHGVGDQVLIAFATWLRRLV
GNQYTVARFGGDEFVILLTHVPHQRAIALCEELIHSLQQPLRVGERQIFLSTSIGVVFAQNEYETGMAVLRDADTAMYAAKRQSGRRYAVFDTQMYEQVL
ERLHLEHDLRQALNQGGLQLLYQPVVHLQSQRLVGMEALVRWQHPERGLVSPAHFIPIAEDTGLIVALDQWALAQACWQLWTWRQQYSTALVLSVNVSAK
TLQDPTFLQHLDTIRQRYPLPKGQLLLELTERIGIELGSEMLSLLESLRHRHVEISIDDFGTGYSCLSYLHSLPIQHLKVDRSFVSQLEENERNLQIIRM
ILLLSKQLGYRVIAEGIETPKQLQILQELGCDEGQGYLFARPLPPETFASLFL-------
>tr|E0U7K8|E0U7K8_CYAP2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Cyanothece sp. (strain PCC 7822) GN=Cyan7822_1716 PE=4 SV=1
-------------------------------------------------------------------------EKLSKSEERLQLALEGSGDTIWEWNLG
TGELYCDPNWIRRLGYDPREEAINI-EWWRSKIDPETLSDHEAALENYLNGKEYLALEYKIQTLEGEWLWIGGRGKCIAYQQRKPLKILGTHRDITETKQ
TQENLRQQQTIVEQIPVMLAYFDQHYNLLWVNREWEKIWGWSLENRLGKDIRILRSEEKYRLFFDPLWPHFNRSGQWRH----RKANGEIIHAWTELSGV
IDEEGEFALIISMAIDITERKQAEEQLRHSVLHDGLTGLPNRTLLLDRVEQAIKRKQQQPYLFAILFIDLDRFKVVNDSLGHLVGDQLLKTIADKLQRCV
RPTDTVARFGGDEFVILLEDLTITDATKMAQRITEEFESSFTLQEQEYFTSASIGITFCSSPEQTPSELVRNADIAMYRSKEAGRARYTMFDPIMHTQAT
QLLELETNLRLALEREEFIVYYQPIVSLMNRNLLGFEALVRWIHPEKGVISPANFIPVAEETGLIIPLGEWVLRESCRQMKAWQEQFIGALRVSVNLSGK
QLQQPNLINRIDNILTETGLEGKNLKLEITESMLMNNKEQVSELLLQMKAKKIQVSIDDFGTGYSSLSYLHYLPVDTLKIDRSFVSRMSQVGENFEIVEA
IITLAHHLQMDVVAEGVETEQHLRQLQQLGCEFGQGYFFSKPLESEKIVSWLE-------
>tr|A0A0D2JAT5|A0A0D2JAT5_9DELT Contig_3, whole genome shotgun sequence OS=Desulfarculus sp. SPR GN=X474_17260 PE=4 SV=1
----------------------------------------------------------------------LAESSLQQTEAMLRLVLDNIPQQISWKSLK
LTYLGCNKSFADAAGFDPEEVIGKAEAWGLRDNRAKDLEVL----DGTS---ARSDTLEPQQQANGKNAWLNSSRIRILNDQEELLGLLVSSEDVTEQQK
AKLKNRLWSKISETTLEGIVILDEKGCIQTVNQSFTELTGYSQQELLTEPFETLVNGPPDVDSLAGLV------KPWMGEIKGHKKEGGFFPALAGLNPI
SNDDGKIIHYVAILHDLTKIKQSEEQITYQAFHDLLTGLPNRRLFSDRLQVALNHASRHSLSLAILSVDLDNFKDINDVLGPNGGDYVLRTTANRLLGTI
REEDTAARLGSDEFLVLLHGRHGDYAIHTAERIISNLGSPLKYKDKKIYITCSIGVTLHPHDGTRADTLITNAQLAMHRAKKQGRSNYQLFTQNMNSEAM
RRVHLDHSLRRALENQELEVFYQPKVDLQTGQVFALEALIRWQEPGGKIIPPDEFIPLAEESGLIIPLGAWILEESCNQARRLNRIFQTPLRMSVNLSPR
QFKHRQLARQVDEILERTKLRPDLLELEITESAMAKNPAKALRTLHELSELDIYLSMDDFGKGYSSLYNLKTFPINSLKIDGSFIRGLPNDLQDAAIVKT
VITLGESMGIEVLAEGVETREQHDFLIKQGCRQGQGYLYSPPAPAKNLDYILS-------
>tr|Q1JZ58|Q1JZ58_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_1298 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------GELRCLEVRLSPVDV--DQKACLFLIIHDITAQKN
ARQQIQKEHTVIDNMVDPVLVLDTSRHIKKANRAALALADGKPEEVRGSLPCDCRSKSC------PMHTVLKTGKP-ASI--IEHIDSKNKIYEIQAAPY
FDESGNMLGVIESFRDITKRLEVERKIYDLTHYDNLTGLPNRSVLLDRVNQAIYHALIKNTHLALISLTLDRFKKINETLGHHVGDCLLQEVAQRLNTLV
PQGQTVAKDSGSQFFILLEEVPQEDVVDLADVVLKGIKQSFHANGHELIPSCSLGIAFYPEQAENSTELLARADVAMRTSKDMGGGAVTVYDPKYGEIAP
QSLRMEADLKHAIENDKLHIHYQPQFNLENDVLVGFEALVRWNHPAEGPVSPGEFIPLAEETGLIHSLGRWVLRQVCQQIHSWEQAGISVVPVAVNVSSL
QMKKNNFVHILEECLNEFQITAQLIELEITESAVMDRLEKSMELLSAIRGLGVKLAIDDFGTGYSSLSYLKSFPFSKLKIDRSFVMDLENDENDAAIITA
IISMAKSLGLKTIAEGVETELQKQFLIKHGCDEVQGFLMSRPLPVEAIETNY--------
>tr|Q1JWP9|Q1JWP9_DESAC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfuromonas acetoxidans DSM 684 GN=Dace_0593 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------------------------------GELRYLEVRLSPVIV--DQKECLFLIVHDITAQQK
ARQQLRKEYMVIDNMVDPVLVMDTSRHIKKANRAAMFLADGKTAEVRGSLPCDYQSQSC------PMHTVLKTGKP-ASV--IKHLDEKNKTYEIQAAPY
FDDMGNILGVIESFRDITKRLEVERKIYDLTHYDSATGLPNRSVLIDRLNQAIYRALFNNSSLALLSLTLDRFKKINETMGHHVGDCLLQEIAQRLKKLT
CDHSSLAKDSGSQFFLLIEGDPKEVVFDFADEVLTEVKQSFFANGQELIPSGSIGIAFYPDHAENATELLARADVAMRLSKDMGGGAVMVYDPKYGEVAP
QSLRMEADLKHALENNQLHLHYQPQFDLKNAGLVGVEALIRWNHPTEGPVSPGEFIPLAEETGLIHPLGRWVLREACRQAKFWQNNFARIVPVAVNVSSL
QLKKNNFVHVLEECLNEFQIDPQLIELEITESAVMDRLEKSMELLNAIKGLGFNLAIDDFGTGYSSLSYLKKFPFSKLKIDRSFVMDLETDENDAAIITA
IISMATSLGLKTIAEGVETVEQKHFLTDHGCDEVQGFLLSRPLSADAIEEMY--------
>tr|W8TQ98|W8TQ98_EUBAC Uncharacterized protein OS=Eubacterium acidaminophilum DSM 3953 GN=EAL2_808p07640 PE=4 SV=1
-----------------------------------------------------------------------------ISNQQYIDIVEGSSEMICKFLPD
TTLTYVNQTYCDNFGKSRNELLGQS---FLTLVPESEHEKIREYIASFTVENDIITYEHKTINSDGYIAWQRWTDRAFFDTNKNIIEFQSVGSDITDIKT
ENEKLSQNERLIGDSSEIFIIMDTDNMVRYVSPSSMEIIGRKPCELIGRNFKLLHPDDRKMEIFLKICTDLRHKM----QCRVLHSTGKYIDLEISFRNL
K-SNPSINGIIASLRDISQLKIAEKKMEHMAYTDSVTGIGNRRELEKILN---EKISTIGTSFGLLFLDMKKFKFINDHLGHILGDKLIQAVAKKLLGSV
SSNITVTRFGGDEFAMIIPLELEENIANVIRCIQQSFEQPIILDKYTLFVSLSIGCAIYPNDGSTIEQLMKNAAIALTRSKSEINTKCVFYVDEMRHQSE
KIFSLMNDLQLALKNNELSIHYQPQINATSGKLIGFEALMRWNHPLLGYIQPSDFISAAEENGLIITLGEWVFAEVCKQVKKWSEQGWINPNVSVNFSAI
QFLKSNFYNSIMDIIHKTGIRPEWIAIEITETAILKNEKLMISALKEFQKSGINISLDDFGVGYSSLSYINKINPDIIKIDKSFIDGIPNDSDKIKMVNI
ISIIATEFNKDLIAEGVETLEQVEYLRNIGCDNIQGYYFSKPLEANAAYDFLK-------
>tr|I9NYC8|I9NYC8_9FIRM Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Pelosinus fermentans JBW45 GN=JBW_02547 PE=4 SV=1
-----------------------------------------------------------------------------NIQENLLQITDAMQDIVGILNPQ
GIIEYITPSCEKLTGYNRNQLIGTC---YLDFIHPDDFEKARTSFYSFLTTNEHRRVCFRYVHASGQVRWLESLREKVEENETS---VVFVARDVTDRIE
AEQEATILEAIFSSVNDGIIIYDVE-------NLSIIKANKKACELFGLLKQLVLTKTQEETWFQKAIQGETPLF----DWKLKNSHGKYLDVEVSLKHI
M-LGGKW-CMLTVIRDISERKYAKEKIYRLANFDILTKLPNRTLFNDRLHIALAHAKRNGEQLAVLFLDLDRFKTINDSLGHQAGDLVLQEVAERLQLCI
RDEDTACRMSADEFIIILTDIEKSNITKIIARLTATLSMPFIVGDNELRITASIGVSLYPHNGHTPEILVRHAELAMYHGKENGRNNYQFFTESLNELVT
ERLSLENSLRLAIERNEFILYYQPQIDITTNKLIGVEALIRWNHPRNGLISPARFIPVAEDTGLIIPIGEWVLREVCQQHFKWLELGLPQIQIAVNVSAI
QFQEKHFLSTLQQILRNYNMNPAYLELELTEGILMRDANTATKELHLLKELGVKLSIDDFGTGYSSLQYLSQFPIDKLKIDQTFIRAMATHVSSLAIVES
IVSLAEKLHIKVIAEGVENNEELKILQTCGCTEIQGYYFSKPLSADKFFEWYY-------
>tr|H6NK79|H6NK79_9BACL Multidomain signal transduction protein OS=Paenibacillus mucilaginosus 3016 GN=PM3016_4827 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------RTGREEKFDSELMLPGGRRIQVQAAVIPLRGRRGEVVRFLCLFRDLTEELA
MKQRYAEHESLFDHSPDPVYALDLEGRFTAFNPA-CAFLGYRPEQLLGSSFLMLVTPEE-------------RERIW--EIFLRSKEGEPQHFELSVIDV
HGVNGEVVGVYGMVQNITERKLMLEQMNELAYFDELTGLPNRRQFMRKVREWLTGAQGGHGKLAVLLVDLDRFKMINDSFGPERGDDIIKKVSERLRMIL
GQEEVLARLSGDEFAIAMEYSENYQLTAAAKRIVASLDTPFAVDAIEFRFTASVGIAAYPQHGLDELALFKHAEYAMYTSKSRGRGQFTVYSDMIQGNSL
ERLSLETQISKGLESGEFTVFYQPQIHLASGRVTGAEALARWNHPERGLVPPGEFIPVAEETGLIVGLGRQMLYEACRQGRAWLDEGHEGLRVAVNVSSK
QLQYDAFAEFVRRTLQETKFPPHLLELEITESVVMDNVEKAVGVLTALSSLGVQIAIDDFGTGYSSLSYLSRLPVQRLKIDRSFVSEMFSTSANQVIVHT
VLAMSESMGLQCTAEGVETAEEAEFLRSLGCAAAQGYYYGKPVPASEFQAKF--------
>tr|B9R346|B9R346_LABAD Putative uncharacterized protein OS=Labrenzia alexandrii (strain DSM 17067 / NCIMB 14079 / DFL-11) GN=SADFL11_3382 PE=4 SV=1
------------------------------------------------------------------------TKELERSRAQLLEAQAIASIGSWECDVS
TKEISASEEFFRITGISPTTASGNLLEQLIERVPATDLPRVKSVVHHALAQCQPFDLEHSILRADGSLARIHTKGRVFKGENGRSVRGIGTVHDITERSN
TERQNRLMAKILETSLNEIYVLNADYKVEYANACAITNLDYTLTELQNLTLWDINQEFSRSTIAE-KLVPLAEGANITGEAQQRRKDGTDYPVDFQIQMV
RDQ-GRN-RIVAMANDISDRVQREERAERLAYFDPLTKLSNRAGCQRD--AGKRFAKT-EKPAFLIHVDMDNFKRVNDTLGHLAGDYCLAETGRRLREVS
RGLGTPYRWGGDEFVILANSS-DSDPNELCERARRLMRAPMEFNGTTFWPTVSMGIALCPDHGTNFETLLVNADLALYRSKHSGKDRFTFYSSDLQSVSD
KETELERELHMAAQRDEFFLVFQPQVNMRTHKVVGVEALVRWQHPERGVVSPGEFLPVVEKTGFAAVLGEIVLDKAFAAAKSWQDAGLDFGRISVNVSPA
HLSSGMLFEQFKTAMERHDLAPERITAEVLESVFLDDHKSHLSTLKDLYEMGVHVELDDFGTGYASLTHVVDLPINGLKIDRSFTQQMLEDDRKEILINQ
LIHLARSLNISVVCEGVETEEQYDRLRMMGDFAVQGFLIARPLRFEDATNWMSET-----
>tr|U7FTQ4|U7FTQ4_9RHOB Diguanylate cyclase OS=Labrenzia sp. C1B10 GN=Q669_09290 PE=4 SV=1
------------------------------------------------------------------------TLKLESSTLQLIEAQRIAHVGSWERDIA
SNEILGSEEYYRVMKIPPNLPANEIQAYLFDRIPGDDRKKTLDAVNAAVKSCGEFDTEHPLVHDDGTIQYLHVRGYVLAGRDGKASKVIGTVHDITDRCL
AERRNHLLANILESSLNEIYILDAEFQIEYANRCALANLGYTIEELKSQKIGDIDPVYDPNTVRR-HVAPLLKGDNLSVESVHRRKDGTEYPVDLRVQLL
RDQ-DRD-LFVAIANDVSERVQREVRAERLAYFDPLTKLSNRAGCQRD--AKERFARS-EKPAFLVHVDMDGFKRVNDTLGHLAGDHCLEETGRRLREVC
RGLGTAYRWGGDEFVILAESG-TSDPNELCERARRIMRMPMEFNGNRFWPTVSMGLALCPEDSDNFDTLLVNADLALYQSKENGKDRYTFFRPDMRTDSE
TEAQIELELKDAVKNDQFFLVFQPQVNLRTQAVTGIEALVRWRHPERGTVSPGDFLPVVEKSGLAPILGEIVIDKAFAAARHWIDQGLDFGRISVNISPS
HLSSGLLLEHFKAAMEKHNVGPERITAEVLESVFLNDNRSHLAALRQLFELGVHIELDDFGTGYASLSHVSDLPINGLKIDRSFTRQMLQDPKKEVIVNQ
LIHLARSLNIGIVCEGVETEEQYDRLRMMGDFSIQGYLIARPMPFDHATDWMSEA-----
>tr|E2CBF6|E2CBF6_9RHOB Pas domain protein OS=Roseibium sp. TrichSKD4 GN=TRICHSKD4_0285 PE=4 SV=1
------------------------------------------------------------------------TAELEASRNRLQQAQKVASIGSWEMDLI
TKEVHWSEEMYNIAGLDPELDGNAAQNQLFSLLPSETLRLIENSLKEAAEKSQGFDFEHEIIRPGGSTRHIHVRGNIQTDEFSDAAKVFATSHDITDWHL
AQQQSLLLADILEASMNEVYLIDARLNIEYANSCGRENLGYSMAELFDCTVRDISPGMTIEQFNS-LVSPLREGSYLKHEGHQLRKDGSSYPVEVRFQKY
LEH-NRD-LYVAIAIDVTERAAREDEAERIAYFDALTGLANRACCQRE--AAIRFDKTNNKPAFLIHLDLDNFKRINDTLGHLAGDLCLEEAGRRLRDCC
GEDATAYRWGGDEFVIIASSS-AADPAVLCNRATSAMRIPMEFEGNQIWPSTSMGVACCPADGETFESLLVHADLALYHSKEKGKDRWSYFAEDMKLDSD
AEAETEKELRRAIANDEFFLVFQPQVNIRTRNVTGVEALVRWRHPTKGVLAPGAFLSVVEKTNLASQLGRVVLDKALQAARNWTDIGFRFGQISVNISPT
HLVSGNLLADFEEMIDTYNLPPSLITAEVLESVFFDDKKSSTDVLEQLHQLGVQIELDDFGTGYASLSHVADLPINGLKIDRTFTAKLLSDHKKEIVINQ
LIHLARALDIGVICEGLETDAQFERLRMMGNFSVQGYLIARPMEFENMTSWLEAS-----
>tr|F2J010|F2J010_POLGS Putative diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor OS=Polymorphum gilvum (strain LMG 2579
------------------------------------------------------------------------TRALAESESRLREAQHIAAIGNWERDLV
TDEAHWSDEIYAIYGVDPKTANPSIRSIL-SQTHPDDRAIILDTLRKALETCSDYEFEHRIIRPDGEVRWLHVKARFALDADGRPVRTVGVTHDITERRR
AEERSLRLANILEASLNEIYLFDAQCRFTHVNRRARENTGYSMDELKQRSAWDLKPDFDESRFRA-LVVPLLEGNSLHFETVHERKDGSRYPVEVQLQLN
TDV-GSP-LFVAIINDISERKLREEAAERLAFFDELTGLPNRAACLRD--VEPLFGDG-DVEHLIIHMDLDNFKLINDTLGHTAGDVYLRATGARLRAAC
AAPARAYRWGGDEFVIVVPDG-DAAARGACEAVFSCMRAPLDYEGATIWPTVSMGIARYPQDGTDFGALMVNADLALYRSKEAGKDRWSFFTTDMKADSD
AEARVEADLYRAVERDELFLVYQPQVNIRSGEVTGVEALLRWQHPLRGALSPAEFLPVVEKSRLAPVVGAIVLDKALAAARIWSDRGLDFGRVAVNLSPQ
HLKAGTFLADVLNAIDKHDVSPDRITVEVLESIFLNDASCKIEVLEDLHRRGVHIELDDFGTGYASLSHLADLPIDGLKIDRSFTAQLLADSKAQVVVNS
IIHLARALDIGIVCEGIETDAQVARLRMMGDFSVQGYLIARPAPFEIFSAWLERR-----
>tr|A0A0C5VU61|A0A0C5VU61_9GAMM Uncharacterized protein OS=Gynuella sunshinyii YC6258 GN=YC6258_01885 PE=4 SV=1
----------------------------------------------------------------------------------LQKTQYDCPLATIEINKN
HKITSFNPAAETLFGVTDQFAIDRE---ITTFL-PERFP--NEHRIYTFSPHN-QQVRCRAVNAVGMELMVDITVTPYI-KYGQTH-YLLFIQNNSERRQ
SDQETQRFEAVSDLAPIGILQTNRNWACTYVNRHWCDICGLTEEELNGHQWNLIHQD-DLENTMTALRQAITEKKEFSIECRFNTPQGETIWVELNARAF
FGLNRKPEGVIATITDNTYRHHTERKLRDMAELDSLTGLPNRALFQERLENALNQSLQE-KGIILLCLDLDDFKNINDSFGHDVGDELLTEVARRLQKCL
HADHTIARVGGDEFMILMEGIEHCVASEVSEKIMSQLAQPCLIRGNELFISTSIGITFAFNFNTNSKTLIKQADIALYRAKSEGRNNYQFYSPELERASK
DRTIIRNSLHNALDRGEMEVYYQLQADVNSGRYVGSEALLRWHHPTRGLISPTKFIAQLEETRLIIPISHWLLQQVVSAYLQWQADGLLDAHISINLSPR
QLYDQHLVKSFEQVLNESGLPGEALVVEITESILLEESPSTLKLLSDLKDLGIQIALDDFGTGYSSLTYLKRYPIDYIKVDRSFMRDILFNQDDESIVRA
VIALAHSLKLKVIAEGVDNHEKVVRLQELGCDYFQGYLLNKPMNMAQTANLLF-------
>tr|Q21G77|Q21G77_SACD2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024)
----------------------------------------------------------------------------------YYLFEGVCPLSVVTVDHQ
LKIVRMNPRAEAIFGYNQNQIIGSH---ISTLL-PERFT--NEHHTQTFAYNP-LASPMIGRSYKGVAINFDVNKLQYV-LKGKRH-HILIMRDTTERAQ
HEDEVERFRILADLAPVGILQANSDWSGIYANDRWCEIAGRSMSDILELGWSAIHPD-HFHNVIEPLRTAISEGKEFKRECLFLKPNSEQTWVELHARPQ
ISTNGDITGFIATILDSTFRHEAEDKLRELAEHDPLTGLANRAMFQHRLEHGLSRTHRH-GSLALLCLDLDGFKNVNDTLGHDSGDELLIEVAKRLTKCV
REEDTVARVGGDEFMILLEGLKDQIAAEVSEKILNSLEPPCSINRQEVFISTSIGITFATGDKNDSKSLMKQADMALYRAKHEGRNNYQYYSPDLERASQ
ERLYLGNSLHHALQRTEFQVFYQFKSSLSTHKVTGFEAVLRWEHPRRGQLQPDQFIPILDESGLIVPVSRWLTHTSFMQHAKWKAKGLIEAKIAVNVSPR
LLRDPYFIRGLANSIQDSKIDPTSVIIEITETALLEHSEQTTDALNGLKRIGVAISLDDFGTGFSSLTHLKRYPIDQIKIDRSFVQNLLKDSGDKAIVKA
VIVLAKSLKLTVVAEGVEDKATLDYLASLNCDEYQGFYLNKPQPAEEIENLLL-------
>tr|A1TTM1|A1TTM1_ACIAC Diguanylate cyclase/phosphodiesterase OS=Acidovorax citrulli (strain AAC00-1) GN=Aave_3762 PE=4 SV=1
--------------------------------------------------------------------ERGMREEISALEARYRGIFDSTSAGIFILSSA
GQLLHASPAFERLLDLQAGRGNEARADFASFFFSSAQLQ---RLIER-ARASEPEAEDLELVRPDGTKVWVHCMVSCMETDAAE-QYVEGVLYDITRRKN
QESAARYRAGLKSRSIETLMFIDLDG-FKSVNDRWGHAAGDANCDAIGRLVDALHPSVSDLARYPAHATTVKTLIHDAAMYAVKQAGKGGIAIAETGVAS
PEENAPESRE----------EAGLPAVVAPQQRDALTGLMDRRNLLEQLASEQSLVAGGAGPTGVICLDIDQFKLLNVAHGTQVGDEVLCETARRLKRVL
RRGDILARTGSDEFVVVLRTEGRDHVEGVAAKLLHSLAAPFNVGQGSLSIRTSAGISLIHADTASGLDALREAQLALRRSKTQGGNHPVFFEENMLAGFH
ERLALEQDLHAAIGSEQLFMQVQPQHDAR-SQLTGGEALLRWRHPERGMVPPDQFIALAEASGLIIELGAWVLKTGCGILADLHRED-PSLTLAINISPA
QFKHPGFVDEVRHALATTGARASGLILEITEGLLITDVNHAAERLAELVELGVRFSIDDFGTGFSSLAYLRQLPLYEIKIDRSFINGLPGDTASVGIVCS
ILSMGSHLGLHVVAEGVETQEQSDFLQANRCPSQQGWLHGRPMPAETFLENVRARKM---
>tr|B6IWY2|B6IWY2_RHOCS Diguanylate cyclase, putative OS=Rhodospirillum centenum (strain ATCC 51521 / SW) GN=RC1_3448 PE=4 SV=1
--------------------------------------------------------------------RRRAEAALRERETRLSGIMDNVADGIITLDED
LRIETMNRAALELFGHA--------ADVVGPFV---------TLID--------------------EGDWTRALMACLRQGDGR-RTAICVVQDITRRKQ
AEQALRDSEGVFDVDANDLLFRE-----------------------------ILHPDDRPAAL-------------YHAFYRLRHRDGSLIWIEARGQAI
RDDRGRPVRI----------TRFEEQLMYVSTHDPLTGLPNRTLLQDRLQHAADQAERKGNSVAVLLLDLDRFKLVNDSLGHQVGDKLLRAISQRLASSV
RPADTIGRLGADEFLIIAEDLTE--AARVAETVLAGLSQPFGLDGQQLFITCSIGITLFPGDATDIGALLRDADTAMHTAKSAGGNGYRFFTPEMNEAAV
ARLSLEHALREAIDQGQFELHYQPKASLETMQTVGVEALLRWRHPEMGMIPPSTFIPVAEETGMILAIGDWVLRAALEQINRWERAGLEPLPVAVNVSVR
QITSSHFADRIQSLLDEYGVRPDLLELEITETAMMSNMAFIADGLAELRGRGIRIAVDDFGTGYSSLSYLRRLPITTLKVDRSFVSEAPSNADTGAIAAT
IIAMGRQLGLTVVAEGIETQEQLDFLRRHRCHEAQGFLIGFPVPAAELEARCLRPAR---
>tr|A0A098ELJ8|A0A098ELJ8_9BACL Cyclic di-GMP phosphodiesterase Gmr OS=Planomicrobium sp. ES2 GN=gmr_2 PE=4 SV=1
----------------------------------------------------------------------------------IKEMTENHGELVLILDET
GKIIRNIEGWTEF-GKEHGL--PEK-YWFFNFIKEFGK---GDELRTKVIGKKEYLDIIPVILKDNSLQWFSIKARPMKTLNENLNGTVISLKLVNLHTI
QA---ITAESVLENMDEGFALLDENYKIHYLNAYGEEVLKSPREENVGMNWWDLFPDALGSKFHQEFDKVILKGTS--------VHFEEYYSTWFRLNAY
PLSSGGMA---LYFQNINERKVTEEKLWEYAYTDFLTGLPNRRAMSELAKSLVQS----KTKFTLFFINLDNLKVVNAMHNFNSGDKVLASVAAKLKELA
GPYSKIGRLDGDEFVVIRQPQGKERLENFAENLKEIFMHPFQLEQQSVNIAASIGIACYPYDAQNLGEVLSFAETAMFEAKKTKETSYCFFRKAMNSERE
RKIKIEKGLQEDLKENGYYFTLQPQIDGATGKVIGVEILSRWNHPELGELSPLEFIQVAEQSSTIVSLTTHLLHEVFTQLKEWQKRYGWNLKTAINMTPS
LLGNPEFFKDFFALIDRYEIQPELIEIEITEQAELTYSDCTLENLQLCKSKCISIAIDDFGTGFSMIAYLTQFPINKIKLDKFFIQKIGEDKKSEAVLAS
LIHLAKSIECELLAEGVERVEEVDFLKEHDCIHFQGYYFDKPLTVADFEEK---------
>tr|M3CW36|M3CW36_9BACL GGDEF/EAL/PAS/PAC/GAF-domain containing protein OS=Planococcus halocryophilus Or1 GN=B481_2732 PE=4 SV=1
----------------------------------------------------------------------------------TQDLINTMDEFLIIMDTN
GIILHANQPWIDF-CITHDE--SSC-FWYFEQLKKKDK---ETEFQLQLLTNNEQKQVEPFFMENGVTQWLQTKVKRILYPFEQTYAVIVCHKPVSPYAI
QP---LTAEIILESMTQGFILLDDQLQIVYINEIAEKLFHCQRRNIVGRELLEGFPKVADTSFYQNFKQALRENVV--------LEFIDYYDTWFEVKAC
PLKTGGLA---LYFQDVTERKRTEVQLVESTYYDYLTGLPNRRLIIETAQSLIEQ----RKKFSVFHFNIDNLNYINAIHHFDTGERIMKNFAEELNGFS
SKTCHVGRLDGNEFIILREVAPNEEMADIAEQMAEVFAHPVELKSQKIHVSVSIGIACFPFDAQTLEELISCADIAMHEAKEVPGSFHSFFNPLMRTSYN
RKSAIEKGLKGNLKENGFYYVLQPQVDGNTGQLVGAEVLSRWNHPEFGEISPPEFIQIAEESGEIFSLTSHLLVEVFTQIKEWQNRFGWNLKTAINMTPS
LLSDPTFFDNFFELLECFKIPSHLIEIEITEQAELTYSSKTLENLLLCKSKGISIAIDDFGTGFSMISYLTHFPINKIKIDKSFVQKIGQNRKSEAVLTS
LIHLAHSIECDLVAEGVETLEESLFLQENGCPVHQGYFYDKPLAPDAFERN---------
>tr|I4X9Q9|I4X9Q9_9BACL PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Planococcus antarcticus DSM 14505 GN=A1A1_00095 PE=4 SV=1
----------------------------------------------------------------------------------VQALIEERDDLVVLLDTN
GFVLLANNKWINY-CPQREW--PAF-SRYLGFLKKTRN---LVELENDMLQGQKHFQLNPSYTG-DRTEWLSTKYRSF-PLDDGSNGVILYQQPVNLQSV
SS---LHNEHILENMTDAFYLLDHQMNFYFLNAQSEQLLHCQRENLIGKNLWAAFPETTKTALYPNYNRAMQERVP--------VKFTEYYDSWFTVRVY
PIENDGLA---VYYQTISKQLAIEEGLGKFACADYLTGLPTRRKIEEEIGALLQK----DTPFSLLYLNLDNFKYINTFYTHKNGDKVIKSIVARLKKLI
DAQDLVGRLEGDELVIVRRHRKDNDVLAFTKKVSTLFNQPFSLGSNFVDVSASIGVISCPADSQEFVDLMTYSEIAMRKAKGQKGSSFCIFDSTMSDNLT
RRMLIEQSLTEDLKSLGFYFAIQPQIDAATSRVRGVEVLARWHHPELGMISPIEFIAIAEETDTIERLTEHLMVDVFSYMKTRENQYGSMLPTAINITPS
LLDSTTFFDKLFSMLDNFGISPTLIEIEITESVELRYSETTLTNLLACRAKGISIALDDFGTEFSSLAYLLDFPVNKIKMDKSFINKIGYDPKSEAVLKS
LIQFVNSVDCALVAEGVEQAHEALFLTMNGCNIHQGYLYDKPMLPKVFDEK---------
>tr|A0A0B5APH3|A0A0B5APH3_9BACL Uncharacterized protein OS=Jeotgalibacillus sp. D5 GN=JMA_28430 PE=4 SV=1
----------------------------------------------------------------------------------EKNLIKLLRLPAAILDEN
GNIRLTNPAWEQF-GPMVDHG-GKE-FNILSPQIKKEC---QKIWRGGSFEYRTLSRS-YCTISKCSDQRMLFQILPSI-----------------DSGV
IT---ENAVDVLESMIEAFFSLDENWCFTYVNHEAEKVLFKKREELIGQNMWMMFPDAWGTNFEEHYFKTMNEQVP--------TQFEEYYKSWFSVHAY
PNSKGGLS---VYFRNINEQKELEHSLWKSANSDHLTGLPNRRFAYESMQNYIDN----QQAFTIFFLDLNQFKIINDLYGHDVGDRLIRKIGLRLQKNL
PDELTISRLGGDEYLIIVPELGKSEVHEFGNRVIAMFSQSFILQRPEIHIDPSVGVSQFPKDGNLVDTLIDKADIAMYEAKKKQSAKAVLYDPVMHESVS
RDLIIQQELKRVIERGELEFVYQPQIDATRNWITGVEVLTRWTHPVLGRVSPAEFIPIAETSGMMEKLTRYQLEWCLRKFSEWKQQYSFEGVIAFNISSG
LFRNKNFIAFLEEAVFEYQIPFNQIELEITENIQLFSHRESVQTLERLREMGMRVAIDDFGTGYSTLSYLNQFPVDKIKIDKHFTDQIMVDEKGEAILVS
IVKLANSLNLDVLAEGVETSEQRDFLLMNGCDDMQGYHFFKPMTLEECKEF---------
>tr|D6XXX4|D6XXX4_BACIE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Bacillus selenitireducens (strain ATCC 700615 / DSM 15326 / MLS
----------------------------------------------------------------------------------ISTALNANPDHAAIISLE
GEILLTNLSWQAF-SRDN-TG-DPD-YTYLDVLKKAGV---TAVYEGSVLEGDFYHNKYPC---PDENRWFIMTVTPLNEG-GDIQGALIVHRNITEVEW
AK---NQTVDILESMTDAFFAVDQNWRFTFLNQEAEKLLQVSRSGLIGQNIWTVFPDALGTTIQFHYETVVDMKLA--------KQFETYFDKWFEVHAY
PRHQGGLA---VFFKDISEKKASEQQIWEMANLDELTGLANRRFIYEKMNGIIQK----RIPFSLFFMDLNDFKDINDVYGHDAGDQVLQKIGERLQALQ
EESGVAARLGGDEFVFMIAELDHEVTGHFAERLLNLIRKRMSVSYYAFSMVGSIGIAMYPETGMNVNEIMSAADAAMYEAKKSKSVTYRFYEISMREVIK
RRIVMGDDMLTAIDRGDFYYVYQPQINMKTGLVDGVEVLSRWKHPQLGMIPPPEFIELAEETGKIRPLTERTIRDVLKTVDGWRRDWGYDGRVAFNVSSS
LIESPSFFTFIKEQMTYFKIGRDQLELEITETVNLAASEALAYHLDQFRHIGVSLAIDDFGTGFSKISHLSRLPVDRIKVDRTFINEIGSGSKGEAILYA
VIDLMNQLEVDVVAEGVEEEEQVRVLMGRNCSHIQGYYYARPTEEEEAVSY---------
>tr|A0A0E0T4C5|A0A0E0T4C5_DESVR Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Desulfovibrio vulgaris (strain RCH1) GN=Deval_2248 PE=4
-----------------------------------------------------------------------ELEALAKSRERYQMAIEATNEGIWEWDVT
TGELYHSPRCVEILGRSAPDTLLRD---LSLQVHPDDRLRMVTLTQSLMEPVERFSLECRMRHPVQGWRWVLCHGVVQRNGSGGPRRITGSIADITERKQ
SEIISQISN-AVNVTHEGLFIHDILRSYVAAENFFIALFPYHTDEKDPSLPEVIRTGRQLLLSYEDLLGRIGTASVWLGPLRVRGKVIGMVLQHYSDDAF
SDSDARLMTSLADIAVAIERKQNEEQLTYLALHDSLTGLPNRTLLLERIEQARLRSLRGGRSFAVMMIDLDRFKIINDSHGHAVGDRLLQMVSAAVRPVL
RPADTVARLGGDEFAILLEDVATREVVHVARRVIKAVERPARVANKLLRTSASVGIVLRTDGYGSADELLRDADIAMYQAKEQGRGRFRVFNRTMHQQAM
DAMNLENDLGAALRWGQFELDYQPVFDTRSRALLGFEALVRWRHPLRGLIPPTAFIPVAEETGIITRLGHWVLETALTALARWRLQGIDDLYVAVNMSAL
QFAQPTLPGSVRDALQKTGLPASCLKVEITETAIMQDPTTALQRISALRDLGVGIGIDDFGTGYSSLAYLQRFPVDTLKVDRSFVSQSTTGEGNREIVRA
VVVLAHSLSLAVVAEGVETEEQFAFLAGLGCDAVQGYLLSRPVPEADIPAHI--------
>tr|A6Q9I8|A6Q9I8_SULNB Uncharacterized protein OS=Sulfurovum sp. (strain NBC37-1) GN=SUN_1192 PE=4 SV=1
------------------------------------------------------------------------QLRLKQENKELGDIIEYAGEVLIVELGT
FRYLYANDAAIRKLGYTREEICRLSIDINREITHKQLRE-FEKEIR---ANGTVL-NRTVYTKKDDSKYPVQTYAQYG--KYHNRDAMIIFNLDISHLVA
IEKKEIEQAQILEQIHDAVISTDLDNKIIHWNHGATELLGYDASEMIGRNIDILYPEDEL---KKAQWMKMQLYGSYRDQIRKQTKEGKMIYTDVSASVL
RDEKKRIIGITRYSQDISQKKEIEKQLNFQAYHDPLTQLPNRTLFNDRLEQTITYAHRHNEKFGVFFIDLDNFKLINDTLGHHLGDEVLKIVSHRFSKCI
REEDTLSRLGGDEFTVLVHELNTESAAKIAGKMMGSLKEEVVVEGQTLHVTASIGISLYPRDAVYKNDLLKYADSAMYKAKEVGRNNYQFYSSEMTNLAM
EKATMEKELRKAIAKNQLRVYYQPQINARNRSVVGLEALVRWEHPEKGLILPDAFIPLAEETGLIREMDYYVMHQAMSDMVEWYHIGLNPGILSLNLPIS
QLMKENFFYTLQNTILKTGFKVKWLTFEITETQVMLNPKHSIKKLYMLNQMGIKISIDDFGTGYSSLAYLKRLPVDKLKIDKTFIFDLPYNTEDCAITNA
VIALAESLHLEIIAEGVEHRDQVRYLLENGCYIIQGYHYSRPIPKQEMTQYL--------
>tr|G2E074|G2E074_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiorhodococcus drewsii AZ1 GN=ThidrDRAFT_1687 PE=4 SV=1
------------------------------------------------------------------------------ELARYADIVSSSPDRIAYVDRG
CRLLAANTPFLRNIGYPFKDVCGDGP--LTAL--------LYRSLGRCLDRQDIVVEDIREIGRNGQPRDAEVRLFPHLDGQGAVAGIVINIRDVTQLRG
SELRLRQSAAVYASTSEGVVITDMDGTIVSVNSAFSQITGYTAAEVVGNKPNLLNSNWHPKRFFVRMWRQLLRTGFWQGEIWNRRKDGEIYWQKLTIRSI
QDSRNRVVNFVGVFAESTASLAAPRRAEHLIHYDALTKLPNRLLFESRLDHALDLGLHKGALVATLLVDLDRFSHINSSLGHHIGDELLRAIAFRLRETV
RPSDTLARLRADQFALIIEDIADKEVEEIARRLQSTLGATIWVNGHEMFVTVSIGIAFNTGSDIERQTIVARAESALRLVKRQGRNGFRIATSGPTEPIN
DQQGMVELMRNGLRKNEFKVLYRVGQHLLNKDCSAVQARLHWAQRELGLIPPERFPLLTNDSGLLLELGQLTLHTACEQLQAWLSRGLPLESMLIGISEA
QLVRGDLVKTLTLLTKQHPLIAHRLELEFSESLLVKHREQIAEVFSGVNRLGILTSLSEVGAGWTAPAVLQRLPIRTLGIHADFVECLSESVHDQAVVQA
VINMAQALNLTTRADGVRSDKQFNLLSNMGCNQALGDLCGEPLCAAEIQALLDPNRAP--
>tr|F9UGX5|F9UGX5_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiocapsa marina 5811 GN=ThimaDRAFT_4178 PE=4 SV=1
------------------------------------------------------------------------------ALARYYDIVSASPDRIAFLDRA
CCLLAANAAFLTALGKSLQEVEGQGP--LSDL--------VYRNLGRCLDGGHPVVDDIYESGPDGQARESEVRLFPHRDHEDKVTGIVVNIRDVTSVRD
SERRLLQSAVVYAATSDGVLMTDADGRIVAVNAAFSRITGYAEAEVLGRKPNLLNSHWHTKSFFTRMWRRLVKQGVWEGEIWNRRKDGEIYLQRLHIRRV
LDGRGKVTNFVGVFAERPVSANGPKHVEYLAHYDPLTKLPNRLLFDSRLAYAMDPARRNRTPVALFLLDLDRFANINASLGHQIGDELLRAVGLRLRETI
RPADTLARLSGDQFGLLFEGIQTTEAQEIARRIRSALQAPMTVRGHQVFVTMSMGIALEACASNDTDVMFAHAATALSNVKHGGRDAFRIYSEPPVGTST
ARQRLAEMLRSGLETGEIELLFEPRVHLETGRWPGAELRLRWHQPDLGPVAHERLLALVESGGMTVELGQWILAEACRQLRDWTLRGTPIGVLSVSISET
QLTRFDLVPSLERLLRSNELDAGRLELSFAESLLFKHPEQAREVINGLHRLGVGVALSEVGTSWLAPQVLRRLPIRRLEIHRNFVDAMPDSPDDLAIVQA
LIAMAQALDIDVTADGVRDDRQRFILLNLGCLEAQGDLFAPPLRAPHYERCLLQISEP--
>tr|D9SH91|D9SH91_GALCS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Gallionella capsiferriformans (strain ES-2) GN=Galf_1879 PE=4 SV=1
-------------------------------------------------------------------------------------------AIVSVTDVT
GTITDVNERFCQISQYSREELIGKNHKMLNSGWHPKGF---FKAMYRAITRGQVWNDEVCNRAKDGSLYWLDMTVVPFMDECGKPYKYIGIRTDITERKK
SAEAIERSEILFDSNSDAVLMLDMQGF-FDCNKAALRLFGCATTEELCKHPADMSPATQPNGLANEYIATATRDGNAQFEWHKRMDSGQSFPADVLLSSM
KL-DGRVV-LQATVRDITERKKSESEIVRLAFYDPLTGLPNRRLLMDRLQHALTSNLRNDKHGAILFIDLDNFKSLNDTKGHAVGDLLLVEVAQRLKGCV
REEDTVARLGGDEFVVLLDNLSHHDTKRVAEKILQALNLSYMLQGYEYHSSPSIGVALFCADASSPDELLKRADSAMYQSKAAGRNTVRFYDERTQALLL
ARAELEHALHHALEQQQLMLYYQVQVNAD-YQPVGAEVLLRWFHPVLGMISPAQFIPLAEESGMIIPIGYWVLEQACDQLKRWASDVFKCLVLAVNVSIR
QFHEADFAQKVQALVTDSGISPDRLKLEITESMLVHDVENIIATMQQLKKIGLNFSMDDFGTGYSSLSSIKRLPLDQLKIDQSFVRDIGHDEHDKAIVRT
IIAMAQSMKLNIIAEGIETEQQRRLLALKGCTNYQGYLFSKPVPLSDFEGLLSRA-----
>tr|A4BMS6|A4BMS6_9GAMM Sensory box protein OS=Nitrococcus mobilis Nb-231 GN=NB231_17378 PE=4 SV=1
------------------------------------------------------------------------------LNEYMDSIIDNADIWLNTLDKE
GRIVIWNKAAERISGYRRDEVQGRTDIWS--WLYPDEAYRIFSHAMDILERGVAFDLETTIRTKDSRQIILSWRSRMLTNTAGETVGSIAVARDVTLERR
AEEALQLHASVFETA-EPLAIANRERVFLRVNHAFTRMFGYPAEEITGRTLLELQPDQSPEDLFARLWGELEATDQWSGELWERRRDGTLIPVRLTMSTV
RDGEGTITHYVAHWQDISERKTFEAQIQCQALYDPLTGLPNRRLANSRLEQELGRAQRLTGFGALLFLDLDRFKQINDAHGHAIGDALLASIAQRLQNLL
RIEDMVARLGGDEFVVLLGSEPGDEAHRVGEKILAAIREPIAIDAYELSVSASVGIALYPDVDMNAADLLQRADSAMYRAKEDGRNTIHFFAETS-----
-RTELEYRQHPSVDDEQLLLSYQPIADIR-GRLASIEALVRWQSSERGLCLPTRFLTVVEETGLTAAVECWALSAICRKLAAWQSVGVFPLRLAVNISPQ
LLTLHDFPRHLRRILRDSGVQPQALVLEITEAALCNDMQQLAGAMRATRGWGIGFSVDEFGIGHTSLAQLELLPIDTVKIAQTLVAEVPGDAAKARALET
ALRMAGRLGVDVAAEGIDTHEQFDCLRSGGCRLFQGSCVSAPLTEEALIALLRT------
>tr|A4U3H4|A4U3H4_9PROT PAS:GGDEF OS=Magnetospirillum gryphiswaldense GN=MGR_2012 PE=4 SV=1
-------------------------------------------------------------------------ADLQSSEEFKTVILNSVQSEIAVLDGH
GIIVSVNEAWRKFAGEQPNAGIGAS---YLGICRAGDGSEKEGALEAAVLSGPIFSMEYP-CHSNTEQRWFAMTVAPLWH--RKIRGVVITHTNISDREQ
SEARLR---TIFDASPDALLISDAQGAITMANSRVEEVLGYMAEDLIGQSIEALVSAEHRSAYIEAPDRRLMLGGR---TIKALRKDGSECEVEINLSRV
DTDQGVM--IASALRDISERRRAEGKIAELSFFDHLTGLPNRTLLMDRMKLAMTASYRDGKHCALLFIDLDNFKALNETLGHEIGDQLLRDIAPRLVASV
REDDTVARLGGDEFLVLLVDLAREEVEAIGLKIIEALSQPYSLNNQHYVCTPSIGATLFFGHV-VADDLLKQSDLAMYKAKAEGGASIHFFDPKMEEAVI
KRAKIEADLRQGLIKKQFLLHYQPQIF-SNGRMTGVEALVRWQHPVRGLVPPSDFIPLAEETGLILQLGNWVLEAACKQLAEWATRPEADLTVAVNVSVQ
QFHQPEFVDHIQEVIRVTGANPERLKLELTESMLAENVQDIIKKMFALKADGIGFSLDDFGTGYSSLSYLKQLPLDQLKIDQSFVRDVLTDPSDATIAKT
IVNLAQSLGLSVIAEGVETEAQRNFLETSGCHSCQGYFFSRPLPIEEFEEYAR-------
>tr|Q2BMA7|Q2BMA7_NEPCE PAS:GGDEF protein OS=Neptuniibacter caesariensis GN=MED92_13011 PE=4 SV=1
---------------------------------------------------------------------------LRNTLKEQEVIFEHAGTGIFIKDSE
RKIIRCNRKFADIYDYRVEELIGQS----SSILYPDFEAFLGDSAYPSLMEGTLYTQKMKMKRKDGTLFWTQIRGNIISSNEPGL-GYIWIVEDIDQQVK
ADEALKVNELILDYAMVGIVFL-KNRSVTRCNQRFEEMFGYNAGELAGSSSRQWYLTEQDKAAGKACYKPLSQGKVFQDEMLLSRKDGSPIWCEVTSKAI
-DPDDLAKGSIWITMDITERKMAEERVKHMALHDALTGLPNRLLLEERLENALSDAKSHQWQLAVLFIDLDRFKLVNDTLGHHEGDQLLVEVANRLHQVI
GANDTVARLGGDEFVIVLNEIAGTEINGVIEDIQQNFKPAVKLALQDMFVTPSIGVAIYPEDGETPVQLMKNADAAMYHAKASGRNCAQYFNRSLDDSLK
ERISLENALNQALKLGQFELYYQPQLDVKSNRIIGAEALIRWNHPEKGMISPDAFIPLAEESGLIVDIGSWVLHQASSQLAQWRKQGFDQLSVSVNLSAL
QVQKESFAREVADVIREYGVPEACLDLELTESMIMRNAEETIAALDKIHNLGIQISVDDFGTGYSSLSYLKRFPLDKLKIDRSFVQDITVDTDDAMICKT
IISMAHNLNLQVIAEGVETNAQLELLRDYGCEQYQGYLFAKPLPVEQMTEHLLA------
>tr|A0A095UAU5|A0A095UAU5_9RHIZ Diguanylate cyclase OS=Rhizobium sp. YS-1r GN=JL39_28115 PE=4 SV=1
---------------------------------------------------------------------KARELNLLELSQRFTLAMEASNIGIWEVAGD
NHDLFWDERAAKLHGKDAASGGNRLNDWL-NSIFPEDRAAAETHFFNCTCSNTPRSEVYRVQLPNGALRYLRSAGANYRHAN-GTHRTTGIVWDVTADMV
MTQTLRNAKLALASSNCGIWESNPVTHVEIWDERMCQLHGIPFAN--GGIHNLLHPEDRERAKRTSYHF-AGSFRPDPLVARVPQPDGSIRYIRSIGKLH
VTRDGTK-KVVGIAFDVTQDELAKSRIEHNSLHDPLTLLANRRKLDMELDRLSRSSQNERQKFSILHLDLDRFKQINDTLGHAAGDAMLVHASHILSRNV
RGSDVVARIGGDEFVILASGNSSEQMAQLAQRIIAEFHQPIDFEGFSCRCGVSIGIAQASGLNVDARRTLVNADIALYRAKGMGRNRYEFFTQNLQAEIV
NQKRTADEVLAGIDNYEFATWYQPQFCARTNEFTGVEALIRWNHPHHGILTPDRFLKIAEDLNVSATLDQIVLETVLKDKLRWIALGIRIPKVSVNVSSK
RLHDETLIDT----LKALQIEPGEISFELVESIFLDESEDSATNLERIKELGIDIEIDDFGTGHTSIVSLLKLKPKRLKIDRQLVMPILSSPQERALVRS
IIDIARSLGVETVAEGVETMQHASLLRELGCDLLQGYAFSRPLSFSDFTQAA--------
>tr|W6WB02|W6WB02_9RHIZ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhizobium sp. CF080 GN=PMI07_003286 PE=4 SV=1
---------------------------------------------------------------------KARELNLIELSQRFNLAMEASNIGIWEVTGN
SSSLFWDNRAAGLHDKPAASEGNRLYDWL-GSIYPPDRTAAETHFVDCASANTPCSETYRVQLPDGTLRYLRSAGANYRNAD-GSLRTTGIVWDVTGDMV
MTQTLRNAKLALDSYNCGIWESNPVTHIETWDARMCQLHGVPFTD--GHIRELIHPDDREHAKLSSYHF-TENFLPEPLVVRVPQPDGSIRYIRSTGKVH
TTRDGSK-KVVGIAFDVTQDEIAKSRIEHNSLHDPLTLLANRRKLDMELDRLSRSSHNERQKFSILHLDLDRFKQINDTLGHAAGDAMLVHASRILSRNV
RSSDIVARIGGDEFVILATDNSSEQIGQLAQRIIAEFHQPIDFEGFACRCGVSIGIAQASGMNVDARRTLVNADIALYRAKGMGRNRYEFFTQNLQAEIV
SHKRTADEVLAGIDNDEFITFYQPQFDARTNQLTGVEALIRWNHPHHGILAPDRFLKIAEDLNVSAALDHIVLQTVLKDKMRWAALGVRIPKVSVNVSSK
RLHDETLIDT----LQSLAIVPGEISFELVESIFLDESEASATNLERIKELGIDIEIDDFGTGHTSIVSLLKLKPKRLKIDRQLVMPILTSPQERALVRS
IIDIARSLGVETVAEGVETMQHASLLRELGCDLLQGYAFARPLSFNDFTEAA--------
>tr|A0A081MXQ2|A0A081MXQ2_9RHIZ Diguanylate cyclase OS=Rhizobium sp. R2-400B4 GN=GV68_01460 PE=4 SV=1
---------------------------------------------------------------------KVREANLLELSQRFSLAMEASKIGVWEVIGD
GQHLFWDDRAAALHGCQGNGLENRLEEWL-NAIYPEDRASAEAHFFTCICAEHTCTETYRIATPDGAVRHVRSAGASYRNPD-GSMRTAGIVWDVTSDAM
MTQTLRQAKLALASYSCGIWEFDLATNTERWDERMCQLYGVPYTD--GIVSTFIHPDDRKAALDVSSRL-QNRDMNDVLLVRVLQADGSVRYVRSVGQLQ
TDRNGNN-KIVGIAFDVTEDEIAKSRIEHNALHDPLTSLANRRKLDVELDGISRGSRDERQTFAILHLDLDRFKQINDTLGHAAGDAMLVHAANVLSRTV
RQTDIVARIGGDEFVIVARGTNSEEMAQLANRVITELRQPIDFEGFECRCGVSIGIAMASGLNIDARRILVNADMALYRAKAMGRNRHEFFTQNLQAEII
SHKRTADELLAGIERQEFVTWYQPQFDAVTTELTGVEALVRWQHPHHGILAPDRFLKIAEDLNVTSLLDHIVLETVLRDKQRWAQMGLHVPKVSVNVSSR
RLHDQSLVEV----LTNLDIPPNQISFELVESIFLDEHEDIAANLEQIKALGIDIEIDDFGTGHTSIVSLLKLKPKRLKIDRQLVMPILHSPQERALVRS
IIEIARSLGVETVAEGVETMQHAALLRELGCDLLQGYAFARPLPFNDFTTMA--------
>tr|L0NB11|L0NB11_RHISP Str. NT-26 chromosome, complete genome OS=Rhizobium sp. GN=NT26_0501 PE=4 SV=1
---------------------------------------------------------------------KAREANLLELSQRFNLAMEASNIGIWEVTDN
GHHLFWDDRSAALHGCEQDGVRNRLDDWH-GAIYPEDLEAAEAHFFNCICAKTACTETYRVATEDGAVRYLRSAGASYHNPD-GSLRSTGIVWDVTADML
MAQMLRDAKLALASYNCGIWEVDLETRTERWDERMCQLYGMRYTD--GIVSKLVHPDDREMAKTVSYEF-QTSGIKETLVVRVPQGERDLRYIRSVGQLQ
VDRNGRR-KVVGIAFDVTEDELAKSRIEHNALHDPLTGLGNRRKLDAELDLLSRQSRTERQKLTILHLDLDRFKQINDTLGHAAGDAMLVHASEVLSRNV
RENDIVARIGGDEFVILIRDENGDCVAQLATRIIGELRQPIDFEGFACRGGVSIGIAQASGVNIDARRVLVNADIALYRAKAMGRNRYEFFTQNLQAEIV
GHKRTADELLAGLENHEFTTRYQPQFDARTSQLAGVEALVRWNHPHLGILTPDRFLRIAEELNVAATIDQIVLETVLKDLKRWADLGVSVPRVSVNVSSR
RLHDEKLIEG----LKLLDIRPGQIAFELVESIFLDEHEDVVANLEQISGLGIDIEIDDFGTGHTSIVGVLKLKPQRLKIDRQLVMPILHSPQERALVRS
IIDIARSLGVETVAEGVESMQHAAMLRELGCDLLQGYAFARPLSFAEFTEAA--------
>tr|A0A0B4X0Q6|A0A0B4X0Q6_9RHIZ GGDEF/EAL domain-containing protein OS=Rhizobium gallicum bv. gallicum R602 GN=RGR602_CH00985 PE=4 SV=1
---------------------------------------------------------------------EARETKLLELSQRLNLALDSSNIGIWELQDH
GHSLYWDTRASGLHGQPAGEGSHPLESWL-EAIVAADRPIAETHFFNCSLAGTSCTAQYRIRLSDGRIRYLRSVGSFYTDAG-GTGRTIGIVADVTADAE
AADMLRKAKLALDSYQCGIWETTLGTAGSVWDERMHELYGLEPRQ--GFMPSCIHPEDRGFALESARHF-KQLGDKHTLICRVPAEDGSIRYIRSTGKVH
QTATGQL-KLIGVALDVTEDELAKNRIEHNSLHDPLTALANRRKLDIALENLTASSRSQRQKFAILHIDLDRFKQINDTLGHAAGDAMLVHASKVLSKNV
RGSDVVARIGGDEFVILALDA-SEEMAALAGRIIEEMRQPVDFQGFPCRCGVSIGIALANGIHVDARKVLINADIALYRAKSLGRNRYEFFNQNLQADII
NSKRIADEILAGIENGEFTAWYQPQFCARTMRLTGVEALVRWNHPAHGLLTPDKFLRIADEINVVQALDRIVLETALKDKMRWAALGVSVPQVSVNVSAR
RLHDGSLFES----LSDLQIRPGELSFELVESIFLDESEDVAANLDRIKALGIDIEIDDFGTGHTSIVSLLKLKPKRLKIDRQLVQPILNSPQERALVSS
IIDIARSLGVETVAEGIETISHADMLRDLGCDLLQGYAFSRPLSFDDFTAAA--------
>tr|W0IE97|W0IE97_RHILT Diguanylate cyclase OS=Rhizobium leguminosarum bv. trifolii WSM1689 GN=RLEG3_13345 PE=4 SV=1
---------------------------------------------------------------------ETREAKLLELSQRLNLALESSNIGIWELQDD
SNSLLWDARAAALHGKPAEEGSRVLDEWL-AAILPEDRETAEVHFFSCSIAGAACTAQYRILLGDGRIRHLRSVGAFYTNAG-GVSKTIGIVWDVTADAE
TTDTLRKAKLALDSYQCGIWEARPGRGGSIWNERMHELYGLTPRN--GFMTGCIHPEDRALALESARHF-KRNGDTHTLVCRVLVDDGSVRYVRSVGKVH
QTGTGEM-KIMGIAFDATEDELVKNRIEHNSLHDPLTALANRRKLDIALEELTHDGREQRQKFSILHIDLDRFKDINDTLGHAAGDAMLVHASKVLAKNV
RGSDIVARIGGDEFVILALDV-GKEMAQLSTRIIEEMRQPIDFQGFSCRCGVSIGIALANGIHVDARKVLINADIALYRAKSMGRNRFEFFNHNLQADII
NTKRTADEILAGIDNCEFTAWYQPQFSARTMELTGVEALVRWKHPSKGLLTPDKFLRIADEINVVQMLDRIVLETALRDKVRWTARGIAVPKVSVNVSAR
RLHDGSLLES----LADLHIRPGEISFELVESIFLDESEDVVSNLERIKALGIDIEVDDFGTGHTSIVSLLKLKPKRLKIDRQLVQPIVNASQERALVSS
IIEIARSLGVETVAEGVETAAHAALLRDLGCDILQGYAFSRPLSFDDFTNEA--------
>tr|A0A081CYT7|A0A081CYT7_9RHIZ Uncharacterized protein OS=Rhizobium rubi NBRC 13261 GN=RRU01S_20_00940 PE=4 SV=1
---------------------------------------------------------------------RNREAKLVELSQRFKLAMDSSNIGIWEIEND
TSKCYLDERAASLHGFLMVEKRVLLTEWL-TALVVEDRSKAARFFFTCSRGQQTSSEVYRIPVADGTVRYLRSAGSSYIKPD-GSHQTTGIIWDVTADMV
MAQKLRESRLALDSYNCGIWEAAHDYSHAIWNERMCELYGLPPQPQ-RRVTNCLDPEERDSVFNGDM-I-SEADPYRAVVQRIILPDGSLRYVKAVGRLH
MHRDGSK-KIVGIAFDVTADEQTKTRIEHNALHDPLTGLANRRKFDQDLDALSVPTQNEANRYAILHLDLDRFKQINDTLGHAAGDAVLIHAASILKSIV
PDTDTVARIGGDEFVILVRNLVDDHIRSIATQIIAAFSQPFDFDGFTCRYGVSIGIAFGDGTTANARATLINADLALYRAKATGRNRYEFFTQNLQAEII
NHKKIADEILAGLEKGEFEAWYQPQFCAISQEMTGVEALVRWRHPVRGILTPDTFLKIAEELNVVSKIDHMVLQQALQDKEIWRLKGLHVPRVSVNVSVR
RLHDDHLIDS----LKALPIKPGEITFELVEAIFLDENEDVATNIERIKALGIEIEIDDFGTGHTSIISLLRLKPKRLKIDRQLVMPIVASAQERSLVSS
IIGIAHSLGVETVAEGVETHDHAVLLKQLGCNILQGYAFARPLAPEDFSAFA--------
>tr|H4F9Z0|H4F9Z0_9RHIZ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Rhizobium sp. PDO1-076 GN=PDO_2568 PE=4 SV=1
---------------------------------------------------------------------QGREERLIDLSHRFQLAMETSNIGIWDIDEE
THGLHWDERSAGLHGLPVSDNEDRLADWY-ATIHPDDVQKAEQQFFDCVIACTVWDVTYRIELSDGTCRYLRSAGASSINER-GKRRLTGIVCDVTTDTL
VTQSLSQAKLALASYNCGIWEGDPVSRTAVWDERMHQLYGLPYSE--QPVTACLHPDERGDILITTKRA-TTNEQTLNTIQRVILPNNEVRYIRSVGQAH
FGRDGKK-KLIGIAFDVTADELAKNRIEFNALHDPLTSLANRRKLDLELDTLTRKGESQRHKFAILHLDLDRFKEINDTLGHAAGDAMLVHASRVLMRHV
PRGDLVARIGGDEFVILARRATTDELTDLANRIITEMRHPIDFEGFDCRCGVSIGIAQSVGMAPDARKVLINADIALYQAKEKGRNCYEFFTPDLQANII
AKKRMADDMLTGLERDEFIVWYQPQFETNSMQLCGAEALVRWRHPDRGVLASGAFLKVAEDLNVMARIDQLVLQTALKDQMRWTALGVQVPRISVNVSSK
RLHDENLIEQ----LEGLNVPQGSICFELVESIFLDESDTIATNIDRIKALGIDIEIDDFGTGHTSIVSLLKLKPKRLKIDRQLVMPITTQPQERSLVRS
IVEIAGSLGIETVAEGVETHEHAALLRQLGCDYLQGYAFAKPLSFEDFSRFV--------
>tr|K2PEJ7|K2PEJ7_9RHIZ GGDEF family protein OS=Agrobacterium albertimagni AOL15 GN=QWE_13763 PE=4 SV=1
---------------------------------------------------------------------RAREQRLLELSQRFQLALETSNIGIWEIDAS
THALIWDSRSAGLHGLPNSDEEDRLADWF-ASLHADDIGRAEQLYFDAVVAADQWDISYRVPLSDDSFRYLRSVGARTS-----DGSITGIVCDVTTDTL
LTQSLSRAKLALGSYNCGTWEGDPVTRSAIWDERMHQLYGVPFSD--KPVLSRLHPDDRGEIQLATKRA-VTLDQIINTTQRVVLQNGEIRYIRSVGQPH
IGRDGKK-KLIGIAFDVTADELAKNRIEFNALHDPLTSLANRRKLDLELDTLVRNGDRQSSKFAILHLDLDRFKEINDTLGHAAGDAMLVHASRILMKHV
PRGDLVARIGGDEFVVLARRQTSDELATLANKIIDEMRQPLDFEGFDCRCGVSIGIAQSHGAAPDPRKVLINADIALYQAKEKGRNCYEFFTPDLQANIV
AKKRMADDMLAGLDRDEFIVWYQPQFEASSMQLCGAEALIRWRHPDRGILASGNFLKVAEDLNVMARIDELVLQTALKDQMRWTALGMAVPRISVNVSSK
RLHDDNLIDQ----LKGLSITPGSICFELVESIFLDDSDTLASNIERIKALGIDIEIDDFGTGHTSIVSLLKLKPKRLKIDRQLVMPVTVQPQERSLVRN
IVEIARSLGIETVAEGVETQEHAGILRQLGCDYLQGYAFAKPLSFEDFTRFV--------
>tr|B9JSM7|B9JSM7_AGRVS GGDEF family protein OS=Agrobacterium vitis (strain S4 / ATCC BAA-846) GN=Avi_1017 PE=4 SV=1
---------------------------------------------------------------------QQMEDKYRALTRRFELAMDSSNIGMWELATG
NPTLHQDSRAAQLHGSGSGDLDQDMTRWL-ETVHPEDRAKAKAHVMACQQGE--NSQDYRVVLESGVIRTLRSVGSHA-DAS-GHNRVTGLVWDITADVA
MQNDLRAAKLALDSYGCGVWEHDFSTGHTVWDERMCYLYNIPATS--SHITSKIHKDDHEMLMEAARNA-VKQHTRLNTSQRVLLDQGGTRWVRSVGQVH
VDRNGRK-KLIGISFDVTADELTKNRIEFNALHDPLTGLANRRKLDIALDSLTRQSQANRSRFTILHLDLDRFKEINDTLGHAAGDAMLVNAARVLSRHM
NSGDLVARIGGDEFVVLLHGPIDKAAAELAERIIQDINIPVDFEGFICRCGVSIGIAEAKGLRTDARKILINADLALYEAKRQGRNCFQFFTDNLQANIV
SSKRIADELLHALENDEITAWYQPQFCANSMELVGAEALVRWQHPTRGILPSNSFLKVAEDLNVMARIDQIVLELALKDKMRWAAMGVKLPKISVNVSSR
RLHDAGLIET----LESLSISPGEISFELVESIFLDESEDIATNIERIKALGIDIEIDDFGTGHTSIISLLKLQPKRLKIDRQLVMPLLNSSRERAMVRS
IIDIARSLGVATVAEGVESTAHAQILRELGCDLLQGYAFAKPLPFEEFGRFA--------
>tr|A0A069HVW3|A0A069HVW3_ENSAD Uncharacterized protein OS=Ensifer adhaerens GN=FA04_20220 PE=4 SV=1
---------------------------------------------------------------------KAREGEVMTLSHRLNLALDASKIGIWEIDVE
SQQRSWDDRMFHLHGLEVHLDEPTYDEWR-ATVHPDDIGIAANALFRSLDDGLEYRSQYRVILHDGTVRHIRNVGSSHRGAD-GRAKVTGISWDVSDDVL
KNERLSAAKLALDSYRCGMWEADLDNNVAYWDERMHQLYGLVYTD--GATNQALHPDDRQPALNAVNRA-IEADETYVHQVRVILSAGTVRHIRSVGKLH
VAPDGAR-KFVGMALDVTDDEQARVRIEHNALHDPLTGLGNRRMLDKALERLTLDAGSDREDIAILHIDLDRFKQINDTLGHAAGDAMLIHASEILRANT
SSGDIIARIGGDEFVVAVTGEQGATLAARCDRIIAAMRQPVDYNGFPCRFGVSIGVAVGHGADIDARKLLVNADIALYRAKEAGRNRYQFFTEVLQAEVV
TAKRIADEILEGIERDEFEPWYQPQFDATTLALCGVEALVRWRHPREGILTPDRFLGIADELNVTAMLDRLVLEKSLTDQMRWAAAGIRVPKISVNVSAK
RLQDDDLLSS----LEGMSITPGQICFELVESIFLDESDDIVANIEGIKKLGIDIELDDFGTGHTSIVSLLKIKPKRLKIDRQLVVPVLSARREQALVRS
IIEIARSLNIETVAEGVETMAHAEMLGILGCDVLQGYAFARPLSAEKFLAFA--------
>tr|A0A021X517|A0A021X517_9RHIZ Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Shinella sp. DD12 GN=SHLA_88c000010 PE=4 SV=1
---------------------------------------------------------------------RARERQVQSLSQRLDIALDASKIGIWEVELS
TGARNWDEQMHRLHGFPEN-ETPNDHEWR-SVLHPDDVAIARGEMDRIRAGGNDYKSQYRILMPDGNWHHIRNVGSRLTGPN-GEDKLTGISWDVTEDVL
LNEALKSAKLALDSYQCGLWEADLDLGRTYWDERMHQLYGLVFTD--GTVTAAMHPDDREETVQTVNHC-VEHDLPYVREARILMPDGEIRHVRSVGKVH
HAQDGGR-KLIGLAFDVTEDEQAKVRIEHNALHDPLTGLGNRRKLDDELTDIATRSETKDARVGILHIDLDRFKQINDTLGHAAGDALLVHASQVLRACV
HTGDLVARIGGDEFVVVVTNTTDVYLSALSRRIISLMQQPVEYEGHLCRFGVSIGIALAEGRSIDTARLLVNADIALYRAKALGRNRHEFFTEALQAEII
SNKRIADDILAGIENNEFVPYYQPQIDAGTLKLAGAEALIRWNHPREGLLTPDHFLKIAEDLNVMATLDRIVLEKALLDCARWAAQGLIMPKISVNVSAR
RLRDESLIDS----LTGLSIQPGQIAFELVESIFLDESDDVVLNLERIKALGIDIEIDDFGTGHTSIVSLLKLKPKRLKIDRQLVAPILTARNEQALVRS
IIEIGRSLGIEIVAEGVETMEHAEMLGLLGCDLLQGYAFAKPLSRDAFLAFG--------
>tr|U7VBK8|U7VBK8_9FUSO Uncharacterized protein OS=Cetobacterium somerae ATCC BAA-474 GN=HMPREF0202_01074 PE=4 SV=1
---------------------------------------------------------------------------------KFYTLLDNIPYMAWFKNKD
SEYMIVNNEFKEHCGKDFETIRGKGDVWD-GMIGENCRQ-----YDLKVMTERKQLVFDEIIPGKKGYKQFNIYKVPVVDRKNNILGTMGIAKDITDLKN
KDVKFD---ILLENMPFAVFTKNRNGDIIQNNSTFYKLTDVNRFSYISLKEEDFLGKEHKESIEIEDKDVIHNKSNISLVRTLKTKNGEKI-VEVFKSPI
IDISGEVIGIVCTMRDVTEMKSQEAKIKRMAYTDSLTGLANRRGLYNYVESQLVRKY---SDVTIMFMDLDNFKSLNDSFGHQHGDKILIEFGEDLQTIC
R-DGFVSRIGGDEFVIVWEGKLNELATDMAEKILNLLSGKKRK---FNKLSASIGIVTGNTGEETIDNFLTKGDLALYKAKDQGKNQYVFYNRDLDKKRC
LNEEIEQDLRNALDKDELELHYQPQY-TCSKELVGLEALLRWNNDKYRKVPIVDIINIMEKSTLIDEIGKFIIKSAFSFAKKINENREKKVIVSVNISAV
QIMKHNFVRTIKKIITETEVNPSYVGIEITETVLLQNIGENILKIKELKDIGIKISLDDFGTGYSSFSYLVKIPLSNIKIDKSFIWGMKDSEEYRTLVKL
CIDTAHALNLKVVAEGVETVEDLVLLKYMKADFIQGYLFSKPLPKHIIEATVL-------
>tr|C5UWA2|C5UWA2_CLOBO Diguanylate cyclase/phosphodiesterase domain 2 OS=Clostridium botulinum E1 str. 'BoNT E Beluga' GN=CLO_2297 PE=4 SV=1
---------------------------------------------------------------------------------QFDALLNNTPFMAWFKDKD
SNYIKVNNEFMEHSGKTMKQIKGNGDVWS-GMVGDRCRQ-----FDLEVMNKRTQVVFDEIIPGEKGFKQFNMYKAPVINEFDEVIGTIGIARDITDLKN
KDAKLQ---MLMDNLPFPVWLTDINAKYVNGNKKFADYFSVSMDELIGRIPHEFFGEDIVKDIYSQNKEVMEAKETRKFESDIKLNNEIRS-VEIYKTPV
LDIGNEVIGITSALIDITDIKEAQRKIKKQAFTDALTQISNRTALYDYMKNE--SDY---SNIGMMLVDIDNFKDINDYYGHNFGDKVIVHVANELKKIC
N-DAFICRFGGDEFLAVFKDVENNIICDKAEKILEKIHMYK-----EHDFSVSIGIAIGDD-ISDINRLLVKVDLAMYKSKELGKNRFMKYTKELEAEKN
LTLNIEKDLKYAIAKNEVKVFYQPQY-TIERKLKGFEALFRWQSKKYANVPVIKIIEVMENSNLIIDMGYYIMREACKFAKKINENRKDKIVVSINISAI
QIMEKDFIKKVKSIINKTGVYIDCIGIEITETVLVKNIEENIMKIKELKDMGVTISLDDFGTGYSSLNYIVNMPLSLIKIDKSFISGMNVKKEYIKLLRL
IIASAHSLNLPIVAEGVETEEQLAKLNKMNVDYVQGFLFSKPVEEEKAFKLLE-------
>tr|B0SRV5|B0SRV5_LEPBP Uncharacterized protein OS=Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris) GN=LEPBI_I3429 PE=4 SV=1
---------------------------------------------------------------------------------AYDKIREKVVVLEVFEENT
KHIINANKQAVVVLEYALEEIVGKEFFMP-PVEVDEDAE-----FEGNLIETALRTKSGRLIPTESSFRLFPVNGKM---------AIWATFRDITDVKN
QKAFYE---FILDNLDSDIAVLNSNFEYEYTNPVFLKKTDVDLAEKLD-LPQEFYERRKFLDIAAKNNEIV------EFEELIQDQNDKVTYLLRKYIPI
DDSETNQKRFISFGVDITERKLSEERITYLAYYDALTGLANRTLFIDHANQALKNHKSTETLLAFYFFDIDNFKFINDSLGHTKGDILLQMVGARLKRVM
TEVDTVARFGGDEFAILKVDVSNSSAAEFAQKILDILSQPFHMG-RDLFTTISMGIALSPNDGVTSAELLKNSDMAMYKAKELGRNNYKFYTNELILRSE
KRLYIENSLRKAIQNEELLLFFQPKISTITNQVCGAEALIRWKHPERGWVPPIEFIPVAEDSGIIERIGDWVLEEACRLKKQWSEKNLPSFPLSINVSGK
QLARANWSHRVQATILQYGINPEEIELELTESSIMENPEKSIEAFEYLSELGIKVSIDDFGTGYSSLSYLKKINADVIKIDRSFVVDLELNEDDRAICKA
IINMAHSLGLEVIAEGVENPAQRDLLHDLGCHMIQGYLYSKPLPEDEFVVFVQ-------
>tr|U5T724|U5T724_9GAMM Uncharacterized protein OS=Spiribacter sp. UAH-SP71 GN=SPICUR_05285 PE=4 SV=1
---------------------------------------------------------------------------------SFQTLLDASDNLCAIVDSD
YRYCWTNATYQRLHAPSLDTLVDRH---VGEIVGEAHFEHVQPHLDSCLD-GQPQCFATERPSPSLGRRDLEVRYYPLTRAQSGERQIGIVIADTTDRRE
CERDVHKMMSITHLNPSPIAITDLQGRMEYVNPALEQISGYTRDELVGHTYAVLKSGNTPDAVYRDLWETISAGRTWTGEFENRRKDGSLYCEYTLIAPL
RDDDGAIVNYATIKQDTTTLRATENDLARSAFEDPLTGLSTRNGFSQALQGRLDQGGWQ-SEAIVMMVDIVGLRDINDAYGYDGGDRLLIEFSQRLSQLT
SDPRLAGRIGGDECTLFLESDPDDAIEARLERIVEHLSRPFDLDGVAIDIAIRMGYTRMGHRIRPAERLLREAERALFRHRAESTLPWIAYTDRLEQQTR
ARIDLTRELRTALQDNQFELHFQPKLDLASGYLVSAEALLRWNHPERGLISPGVFIPIAEQSQLIGPIGEWAIRRACEHLRAWQDEGLDLVRVAVNVSLV
QFRTGHFPDSVRRILEESGTAPEQLSLEITESVFAQESASLLRQMRELRDMNVRLSLDDFGTGYSSLLYLQQYPFDEIKIDQGFVTHLMSDRFSRNIVEA
VKMLAHALDAEIMAEGIESDSVRRELLMMGIHFGQGFYYSYPLEAEDFRWLLE-------
>tr|B2JAQ5|B2JAQ5_NOSP7 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Nostoc punctiforme (strain ATCC 29133 / PCC 73102) GN=N
----------------------------------------------------------------------QALEALGKQEEQYRRIVQTATEGIWLLDKD
NCTTFVNQQMATMLGYTIEEMLGAT---LFSFMDSEGLE-IANSCLSRRYQGIQEAHDFKFRCQDGSDLWAIISCAPLLDDQGNYAGALGMVTNITDRKL
AEAALQESKGILCSLEDVIWSISADFETLYLNPAALKVYGYSVSEFFEN-SNLWFEVIHPE-DQQQVHAALFLTEKQELEYRIVRPDGQVRWLLNRSHLI
YNASGLPIRIDGIATDITERKLLEEKLVHNAFYDALTGLPNRILFIDRLEQAIAQMKHNPDLFAVLFLDLDRFKVVNDSLGHLVGDQLLVTLAQRLQQCL
QPDDTVARLGGDEFTILLSHIQTEDATDIAKHIHQALKPPFNLCGYEVFMTASIGIALGTNKYVQPADLLRDADTALYRAKEQSQAGHIVFDTTMYDRAV
ELLQLETDLRWAVERQELCIFYQPIICIKTGKITGFEALVRWQHPERGLISPTEFIPVAEETGLIIPIGQWVLTESCKQLRQWQLQFPAPLTLNVNLSGK
QFSQPHLIEQISQILQDTGLSSSNLKLEITETAIIASPQKATSILKQLKAFGLQLCIDDFGTGYSSLAYLHNFPIDVLKIDRSFVNRIDSDTEQFAIVRA
IVTLADNLGMSVVAEGVETINQLAQLQLLQCQQAQGYLFSKPLDQEQARNLLAS------
>tr|Q8YSB9|Q8YSB9_NOSS1 Alr3170 protein OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=alr3170 PE=4 SV=1
----------------------------------------------------------------------QVLETLQQQKEQYRRIVETASEGIWLLNQN
NETTFVNQQMATMLGYTIEEMLGAS---LFSFMDAEGLD-MAQDLLSQRRQGIQEKHKFKFRCKDGSDLWAIISCTPLFDEQRNYTGALGMLTNISDRKQ
AEASLQESKGILNSLEAVIWSIAADFEMLYLNSAVVQVYGRSVCEFYDN-PKLWFDLIHPE-DQQRVSQSLLANGSHELEYRILRQDGQVRWLYNHSHVI
YDAVGQPIRIEGVATDITERKNMEEKLVYHAFYDDLTGLPNRVLFMDRLAQTIDQAKESPDLFAVLFLDLDRFKVVNDSLSHLVGDQLLVSFAQRLQSCL
QPEDTLARLGGDEFTILLSHIQSDDATRIAEKIHQALKLPFNLSGYEVFTTVSIGIALSTNDYVQAADLLRDADTALYCAKEQGKAWHIVFDSTMYDRAV
ALLQLETDLRWAIARQELYVVYQPIVSVATGKITGFEALVRWQHPERGLISPVEFIPVAEETGLIIQIGQFVLRESCQQLKQWHLEFPEHLSINVNLSGK
QFSQPYLVEEIEQLLQEFDLDPSSIKLEITESAIMASPGQAATILQQLKTLGIQLCIDDFGTGYSSLAYLHCFPIDILKIDRSFTKRIDSDSEQLAIIRA
IVTLASNLEMSVVAEGVETVNQLVQLQLLKCDQAQGYLFSKPLSSDKVSLLLAA------
>tr|B0C776|B0C776_ACAM1 Diguanylate cyclase/phosphodiesterase with EAL and GAF domains OS=Acaryochloris marina (strain MBIC 11017) GN=AM1_5088 PE=4 SV=
--------------------------------------------------------------------------KLDHLSAACPAVMYSSCPGAY-----
-ELTAVSKSVTSLFGYTDQDLLAEPTRWL-SLIHPDDRSL----ALETLSQGVWQECEYRFFHKQLGYRWVQNIFQLVSKPNGPGLELIGCWLDRTEHLQ
HRLAQQQRDAVAEASHFNTAVTKADRLYVCELHVLTPQLRY---AWVKKSASLPWTVPSDVIGQRRWYQSLVRRLPFSQEIRSHLKRADICSV--FLLPI
I-IEDQLWGFMSSTPDISKHHQKETELLHHAFHDPLTDLPNRALFINRLEQSLKQLQRYPYLFAVLFLDLDRFKIINDSMGHGVGDQLLMGIAERLLSSL
RPGDTASRLGGDEFVILLNGLQNEDATSTAERLRQQLTLPFNLGVHEIFIDVSIGITLSNFGYHDAEQVLQDADVAMYQAKSAGKGCHKVFNTGMQSQTM
ARSQLETEMRRAIERQAFEIYYQPIVCLKTGAIDAFEALIRWYDSNHQPIAASDLIGIAEESGMIQDLGLSVLQQACNQLRQWQRLDYETLRISVNLSAK
QLFHSDLVTKVADIIAASRIDPTHLKLELTESTIIRNDQTTISLLKQLRELGLELYLDDFGAGYSSLSYLYSLPINALKIDQTFVQRIDMGAEGQAIIRS
ILLLANNLDLQVVAEGVENKIQLNYLNSLNCTHGQGFLFAPPLTARGATSLLRSQ-----
>tr|B8HMI3|B8HMI3_CYAP4 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Cyanothece sp. (strain PCC 7425 / ATCC 29141) GN=Cyan74
-------------------------------------------------------------------------------EARCEQIVANNPDGSQ-----
-GFVYISAGCEEIYEIAADQIVQNAQLVW-SLIHPEDRRE----FEEAMTAAWWNEH--RLITPSGQLKWLRFSLQPKLQADGT-IVCDGMILDISDRKQ
AEQALMKRETLVEIQSEGNFYNHVDRVYVFENSQFCTSQKA---EWCAAPAQMPYA-----EFVPRWLTLLGQGGIVAGLQRVILEPQGIVSL--LVLPL
F-VHHQFFGFIGEPSDIDERQQANAQLVTVSLRDALTSLPNRTLLFDRLEHALQRYQRHPQQFAVLFLDMDRFKSINDSLGHTAGDQVLLEMAHRLSQSV
REEDTVARLGGDEFVILLEEVMNQDALHCAQRIQDILAVPFELNGTVVSLDASIGVALADARYHTPEELLRDADIAMYEAKAAGRGGYQVFAPQMHEQAK
LRLQKEQDLRLALRKEQFQVVYQPIVNLLNHALLGFEALIRWQHPQGVQIPVPEFLTIADQLGLLVKLEWWVLQTACEQLAQWQSLGLAGRPVSVNVSST
LFAQPNLVPEVARLIQQFKLPPQGLKLEITEGVIGANADVALENGQALQSLGVQLHIDDFGTGYSSLKRLHQFPVHALKIDRSFVRHLDQSSENREIVRA
IVSLANTLGIDVIAEGIETEQQCHYLQTLACQQGQGYWFAPPLTTAEVEQMLLQQ-----
>tr|E8UZX2|E8UZX2_TERSS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Terriglobus saanensis (strain ATCC BAA-1853 / DSM 23119 / SP1PR4) GN=AciPR4_0211 PE=4 SV=1
----------------------------------------------------------------------------NQNEHRFIAAMESSLSAFYLLDSD
FRFVYLNGHAEKLIHRRSADLLG---KWLCTE-IPMNRTAFFDKYRKVVETGIPFNEEASVSSVDVDAAWVHLQVVRL--GDG----IAITTTDISLRKR
MEIQLEKALAIIDASPFSTIVTDLEGNIVAVNPATERMLWYTKAEMVGKTPLSLHDPVELKAFIVGPKRGMAEEN----EWTYIRKDGSRLPVQLTVTAL
TDDYGHETGYMGIAYDITERKRQQDYISHLAHHDSLTGLPTRILFKDRVDVALARVQRYGGKCALMLIDLDNFKDINDSLGHHAGDEVLIVIAQRLKEVL
RSTDTVSRMGGDEFTVLLDHITSEDATTAAVKLLATLSKPILIGEDLLPISASIGISIYPEGGATSGNLLKNADAAMYYAKGSGKQSYRLFTQGLADATT
KRLQMEMALKKAIKSQEFSVVYQPQVALANDVIIGVEVLARWKSERLGVVPPSDFIPIAEQCGVIAPLGEWILRTACNDVKALSDSIGRPLRLAVNVSPR
QLEREGFAARVALILVETMFPAEMLEIEITEGVLMSDSLLVWEALKDLQSQGVQMAIDDFGTGFSNISYLLKLSVNQIKIDRSFITNLEDDPGCDAVVGS
LISMANTLGVTVVAEGVETEGQRDILRAKGCHEAQGYFYHRPMDVADLMKVLQ-------
>tr|A0A066RW30|A0A066RW30_9GAMM Uncharacterized protein OS=Photobacterium halotolerans GN=EA58_11205 PE=4 SV=1
------------------------------------------------------------------------KSELHDMVKKYSHVLKHAPDGMVILRQD
NTIIDLNQSACQILDTSTEAAKTRQ---IADLVTHEKADELSELLVQSMSQGESQPISILITNTIEPPQHLEIIATETAYNDGNE--VLLNIRDVTNWVE
REEKLKSMSRALEQSDDSIIITNDRGIIEYVNHSFEAFNDMNANDLIGSDAHLILATLQNPTELERLQHQLRRGHTVNRIISHRRKDNSLMYMEKRISPI
RNSRGKISHYITTGKDITERVLFESKLKRLAHFDMLTQLPNRLMLQQQIESLQKQSP--RPELGLMTLNLDRFKQINDSLGHDTGDQVLIAVSKRLQQIL
REGDILARLGNDEFGILVVSDTRPVLEELAERILRHLNHPITLDNKEVVVSASIGITYCGDGECTSEALLRQADIALYKAKDNGQQQYRVYNREMGVNSV
KRLEMEAQLRQSFGSDRYQFFYQGRFEARTRKLCGVEALLRWYDDDGVLQSPSEFVPILETTGLIIDVGERMIRKACQQLRQWQLQGHK-LHFAINISAR
QLLNSDIINTVQQAIQSSHCDPSYLELEITESVVMSDVKLALNRLRQLNALGVRIAIDDFGTGYSSLAYLSRFPIQILKVDQEFVRDLPVNRESVTITNA
IVELAHNLNIRVVAEGVESQAQADFLSSIGVEEFQGFLYCKPLSISDFESAFLHPAL---
>tr|A0A0A3IXB0|A0A0A3IXB0_9BACI Uncharacterized protein OS=Lysinibacillus odysseyi 34hs-1 = NBRC 100172 GN=CD32_02395 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------RKTGIPFYAGLECLPFQDEQNKTKLVLVFVKDVTYIQL
QSFVDRLEKEMFQAIQNEISFRECFTAFVWEHEGKCQMNVWHPGKTIQYTLEQ--S--VERTCYEKLYDDFSHLHLHR-PHKDLALEKEFTRCI--FLPV
GKSEGEKLGVMTIYFEQDYKNKKQQQIYSLAYMNLSTGMVNLNGFIGRLKELK------EWDGVIHLVEPTEFSRIVELYGRDSGEALLKQMYERILEKC
EKHILVGRFVSSSIILYMEK--DAETRHMTEFLKTLVEQPFIVEGRSIYITLKSGGAPIRTGQS-IKEGIRHAESALSEAKESFGTMARFYCEEKDAQLE
KELLILNHLTEAIKHKEITAFFQPKVELRRGRITSMEALARWTSPVLGHVSPADFIPVAERAGLIREIDLQIIEQVLRWFQRRQYEGKHIVPIAVNISPE
HFYYPRFVEELEQLIKKYHADPNYLIIEITESLGLVDVKRAQEIIKKLYIRGLKTSVDDFGMGYSSLSYLQKLPFSELKIDRSFTSRIH-EAGTLAIVRS
IIQIAYNLEIDVVAEGVETKEQADVLYQLGCKCAQGYLFYRPMSFRELEESNI-------
>tr|A0A0A3I9J9|A0A0A3I9J9_9BACI Uncharacterized protein OS=Lysinibacillus manganicus DSM 26584 GN=CD29_02060 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------HKRGLPSLVDVTSIPFHVENDNNILVLLLFEEFSKFHL
DHTLHFIEEQIYTAIEKESSLFNTVSTIIIKNDNDINSVMSHNNELSEIIIER--K--AEIEYYKQYIKDTKDIRVHA-YHKKIVEGKQLLKSL--IVPI
KNHANDRIGVIFMFSNISQEDQKLREISYLAYNDVPTGIPNRLGFTEKLRELEQ----RQIFGFIHIIEPTEFSEIVELYGRDAGDELLKQLCRKMNMMR
REEDFIGRFSSSKIIAFTNCI-VEKIPDFEAIMEILVETPFIVQNNQVYITLKNGTSPFNEKVS-YNDSIRFAENAFRKAKSKAGNVVMEYKNEMDRNLK
QNLLISSHLTEAVKNKEIQVYFQPKINLKNRTVSSIEALARWNSPTLGFISPQDFMAVAEKTGLVRDIDLQVIELVLQWFQNRKKDSKKVIPVAVNISPE
HFYHPRFIDQLSDLVKKYDADPTNIIIEITENMSLVDLPKARQIINELNAKGFSSSVDDFGMGYSSLNYLQELPISELKIDRNFTMKLH-DSGTYAIVKA
ILQIADALNIETVAEGVETEEQARILKELGCNTGQGYLFDKPIPVEEFNRKFE-------
>tr|R7ZIZ9|R7ZIZ9_LYSSH Phytochrome-like protein cph2 OS=Lysinibacillus sphaericus OT4b.31 GN=H131_05129 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------CFEKPPFWSEIQALPFQNNEGETLFVLLLVKDVTYYHT
ANFLNRLESAMYEAIEKDDPFPYVNSMILIKTEANQLR-VFTENCKGEKLSEV--I--EWYEYYRRAAEDLEVIDIPQ-EHKKFAYSFDKQSAW--FIPI
RNQQQRVIGLFAIFHQYPSHHKTQKRIWDLAYMDITTGLPNRHSFVNRIEKEKE----QGQHGFIKVLKPSEFHQVVELYGREAGDELLRQIAKRLNDNN
NHNEYIARFTSSSLIISCMT--PEDLTNYDRRIKELIRQPFIIRSKQIYITLKTGIATFDKDIK-IADAIRFADNALSYAANKPGTHMEVFTKERNEELE
QQMLVLNHLSHALKSKEISVNLQPKVDLRTGEIQSIEALARWISPTLGIVSPATFIPVAENAGKVREIDTQILEQVLAWLEDRQRLGKKLVKVAVNISPD
HFYHPHFVKDLLKLVRQYNIDPSYIILEVTENIGLVDFQTALAIIQELKSYGYKTSVDDFGTGFSSLSYLQRLPFTELKIDRSFINDIN-DAATLAIVRS
IIQLALNLGMTSVAEGIENEEQVEILRALGCTVGQGYFYYKPMSIEQLDTILD-------
>tr|D7WWW4|D7WWW4_9BACI Phytochrome-like protein cph2 OS=Lysinibacillus fusiformis ZC1 GN=BFZC1_18290 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------GIDKPPFWAEIQALPFCNEASITQFVLVFVKDVTYYHT
EDFLMRLENDMYRAIEKEFTFPNIASMVLIKTEVNQLQ-VFIGDNQTKSVPRC--C--ANNDFFNKVIENLDEVNIPE-EHKQYASLAKKPHGW--FIPI
RNQQRQVIGVFSIFSKTQSD-RTQKKIWDLAYTDITTGLPNRHSFVNTIEREVQ----QGQSGFIKILKPSEFHQVVELYGREIGDELLRQLAKRLEQDK
SSIEYVARFTSSSLIMTTMS--LEDLHDYEMRIKETIRQPFIIGGKQIYITLKTGIASYSDDIN-INDAIRFADNALSFAIDRPGTHTEIFTTEKNDVLV
QKMTVLNHLSEAIKNKEITVHLQPKVDLRNGDIQSIEALARWISPKLGFVSPAVFIPVAESAGKVREIDVLILETVLSWLSERQRLGRKLVKIAVNISPD
HFYYTHFVQDTLKLVRKYNIDPSYIILEVTENIGLVDFQSAYKIIQELKSYGFKTSVDDFGTGFSSLSYLQQLPFAELKIDRSFINAIE-DPATLAIVRS
IIQLALNLGMISVAEGIETEEQVEILRALGCTVGQGYFYFKPMPIEQLDIILD-------
>tr|X2GT90|X2GT90_9BACI Phytochrome-like protein cph2 OS=Lysinibacillus varians GN=T479_02785 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------RFEKPPFWAEMQTLPFQSHNNETLFVLVLVKDITYYHT
EDFIMQLERAIYEAIEKDEPFPFVFSTILIKTESNQLQ-VFTSNRMRDHVPQF--C--EMNDFYRQVTNNLEDIAIPI-EFKRFANTTNKQIGW--FVPI
RNQKQQAIGLFMIFSQYSSESKTQRKIWDLAYKDITTGLPNRHSFLNKIEQEEQ----RGHIGFIKIIQPSEFHQVVELYGREAGDELLRQVARRLQEHK
TINEYIARFTSSSLIISQVT--HEEFSDYEQRIKELTRQPFIINGKHIYITLKTGISYFDKAIK-IADAIRFADNALSYAANKPGSHMEIFTKERNDLLE
QQMTVLNHLSQALKNKEISVNLQPKVDLRTGEIQSIEALARWHSPILGFVSPAMFIPVAENAGKVREIDSQVLEIVLAWLAERQQLGKKLVKVAVNISPD
HFYYLHFVRDIRQLVEKYKIDPSNIILEVTENIGLVDFQTAFTIIKELKSYGFQTSVDDFGTGFSSLSYLQRLPFTELKIDRSFINDIK-DAATLAIVRS
IIQLALNLGMTSVAEGIENEEQVEILRALGCTVGQGYFYYKPMSIAQLDTILD-------
>tr|A0A0B1XY74|A0A0B1XY74_9BACI Phytochrome-like protein cph2 OS=Lysinibacillus sp. A1 GN=PI85_15190 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------GINKPLFWAEIQALPFRNDTNITQYVLVLMKDVTYYHT
EDFLMRLENDMYKAIERDSSFPKTSSMVLIKTESNLLQ-AFTDNCRSKDVPRC--C--ENIDFFTKVIENLDEVHIPD-EHKQFAASSHKPYGL--FIPI
RNQQRQAIGLFSIYYQAQNDSRAQRKIWDLAYTDITTGLPNRHSFVNFLEKEVE----RGQNGYIKIVKPSEFHQVVELYGREFGDELLRQLAKRLEQDK
PDREYIARFTSSSLILSTMT--FENLNKYESRIKETIRQPFIIGGKQIYITLKTGIASFNDDIK-INDAIRFADNALSFATDKPGTHIEIFTTEKNDILV
QQMTVLNHLSQAIKNKEITVHLQPKVDLRNGEIQSIEALARWISPKLGFVSPAIFIPVAESAGKVREIDVLVLETVLSWLAERQKLGKKLVEIAVNISPD
HFYYTHFVQDTLKLVRKYGIEPSNIILEVTENIGLVDFQSAYKIIQELKSYGFKTSVDDFGTGFSSLSYLQQLPFTELKIDRSFINALE-DPATLAIVRS
IIQLALNLGMISVAEGIETEEQVEILRALGCTVGQGFFYFKPMAIEELDLILD-------
>tr|A0A0A3JX20|A0A0A3JX20_9BACI Uncharacterized protein OS=Lysinibacillus massiliensis 4400831 = CIP 108448 = CCUG 49529 GN=CD30_05760 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------HKDGSPFWNYLYSLPIKDETNEVQFTLICCKNITDQML
DKMLSKLEREVYAELDKGGDTRSVYCAIRVLDSTGELKTGSLPSTLIENAYII-----EPTAGFNEKHKQIELN---N-NIYNDISSLEVISCW--TKPI
VNQHHHILGSITIYLDQASLKEQKQELERLAFYDMNTGIPNQNYFYTNLTEWIE----GDFTGIILIIQPGEYSGIVDLYGRKTGDELLIQIANRLKNHQ
KEDIIYGRFSNSSIITAKKIY-DDKIDLYVSRLRELTTSPYVLADREMFISLNIGIAHFGNGVL-MEESIRQADIALTSSRKKFGTVITFFEEETNKLMQ
QEMDTLNQLIHGLKNNEFSAFLQPKVNLKTAEIEGFEALARWHSPVLGSVSPATFIPIAEYSGKIREIDNAILKQVLKWQQARKEKGLKLVPVSVNISPV
HFYHDTFVDDFISLVHQYHISPEYIKVEVTENFELVDFEKAKNILMRLKEYGYESSIDDFGVGFSSLSYLQQLPFSEIKIDQSFISNMN-NDEMFAVVQT
IIQLASRLKMHAVAEGIETVDQYNLLKNIGCNTGQGYYFHKPMPINEAEKLLN-------
>tr|A0A0A3I9Y6|A0A0A3I9Y6_9BACI Uncharacterized protein OS=Lysinibacillus odysseyi 34hs-1 = NBRC 100172 GN=CD32_19475 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------QKDDSPFWHELVAHPICDQEGVAQYIMVHSKNVTYEKL
FKMLSKLEHEVYLEIEKGDSLRNIYCSIHLMKDGSSMASGSLPLEMANYGIEL-----HSMKTEDRNKKELAAA---N-EMAHTPLKIDIKHCL--SKPI
CGTANEIIGSITMYFKEPNINAQTQQLRQLAYFDSETQLPNLHYFHTEMETWLQ----QGEKGLIIIIQPGEYSSIVDVYGRSAGDEILRQMVDRLQEQP
SGKEFIAKFSNSCIIFASNRA-FGQPEQYEARIRQMTKEPFGIHGKEFYITFKIGMTHFCPDSQ-LDEAIRQADMALSKARQVSGTNVAFFEEQNDMKLQ
LEMDVLNQLTYGLQNKEFYIVLQPKINIKTLEIEGFEALCRWNSHILGPVSPATFIPLAEQTGKIKKVDELVMRQVLRWQRTRLDSNEKTVPIAINISPV
HFYDERFVQQIVSLIKRYKVPPYLVKLEVTESMELVDFSKAKDILSELRQHGIECSIDDFGVGFSSLSYLQQLPFREIKIDRSFINAMD-NPGMHAVVHT
IVQLASNLQMNAVAEGIETPEQFESLKQMGCHTGQGYYFHKPLVLEDAAKLIH-------
>tr|A0A0A3IPN8|A0A0A3IPN8_9BACI Uncharacterized protein OS=Lysinibacillus odysseyi 34hs-1 = NBRC 100172 GN=CD32_10070 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------RKDGSGFWGDITVIPFSADEKKVQFYFFVINDVTEVVH
MDTLVQLERKLYLSLEKDYQLRPNKCSIFLVEGNR-LQQSTIPEDLKKNNLDI--S--RYMGDEKTSSSNIQEHEGWS-DFHWVLKKYQFVASW--SQPI
KNHQGETVGIFAVYFEPITPRKQKSEILKLAFYDERTGLRNIASFEKEMAHIGG----QRESGVIYIMEATEHQYIVDLYGRVGGDALLKQLADRLGAIP
GQEAIIARYTSSSIIVAILNE-DN--QEILLPHIELTFEPYMIDGKNVSITLKIGAAIFEGEVT-GTMAIQHADTALFSASKLPGTVLHLYEESQRHSIE
KELEVLTLFASALKNKEFFPMLQPKVDIQTREIIGFEALARWESAEIGFVSPAIFIPVGEKTGNIHKVDRAILKSVLAWQRERKKQGKRLFPVAVNISAN
HFYYPDFVENIEKLIKEYEMDPKYLILEITESIELENVSYAKRNICQLRDIGIATSMDDFGVGYSSLSYLQELPFEEIKIDKSFTDSIA-EPRMHAVVKT
IIQLAADLEMKSVAEGVETEAQHQELKKIGCNIGQGYYYYKPMKLEEVDLLLL-------
>tr|A0A0A3I0Y7|A0A0A3I0Y7_9BACI Uncharacterized protein OS=Lysinibacillus manganicus DSM 26584 GN=CD29_10660 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------HKDGSPFWNCINSFPIKDYTNKVQYTLLYFKNITDNSL
DKMLSKLEREVYAGLEQGSDSRDIYCAIRVLKPTNDLKTGSLPIKVVENEQLL-----EPNIGFNENSKSEK-----Q-LVSDQLHTYAVISSW--SKPI
VNQDKQILGSITIYLNESSLKEHKKELKKLAFTDLNSGLPNQNYFYTNLSNWLE----QKSSGALLIIQPVEYAGIVDLYGRKSGDELLKQIGLRLNSIQ
ESDLIYGRFSNSSIVLAQKMI-KDEVEQFVNNLRLLTQTPYKFIEREMFIDFNIGVSYFCNHVA-LEESIRRADIALTSSRKKHGTVVTFFEEETNNIMQ
KEMDTLNQLIYGLKNNEFTAFLQPKVNLLTEEIVGFEALARWNSPVLGFVSPAAFIPIAESSGKIREVDNAILKQVLEWQHKRKVKGLKLFPVSVNISPV
HFYHESFVDDFIQLVSQYDISPDLINIEVTENFELVDFEKAKEILLKLKSYGYQSSIDDFGVGFSSLSYLQQLPFSEIKIDRSFVNNMN-NEEMYYVVQT
IVQLAANLKMHAVAEGIETLDQYNFLKSIGCLIGQGFYFHKPMPLDDVEKLLS-------
>tr|A0A098EJE8|A0A098EJE8_9BACL Oxygen sensor protein DosP OS=Planomicrobium sp. ES2 GN=dosP_2 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------RKDGLPFWNEITIQPIIMHETNFTFTIMLQRDITDRKR
AEALINLQQQIHNDMGKGYLLDDTKCTVLFVNDAGYFQGKSMPSEFHDEQIQS--S--PVTGTCGAAVEDMKTSPLWN-GLQYLVEELHFTSSW--SVPI
DDANGKAIGTFGIYFDKTLPTQQQEEILRLAYTDKETALPNRNYFINELKELLD----EKKEGFVAFVSADEYIKVVDQYGHTAGDALIREIGKRFLRAG
MANHVIARFSDSTIALVNLNP-L-DVPAYLEKLSQCVIEPINVQDMELFLTLKMGVALITPKQQDEKELIRYADSALSKAKLRAGESICYFENEHDDFMM
RDLRIANELSAALRREEIDVHLQPKVDLKSGKIISFEALARWNSPELGSIAPDVFIPAAEKNGKIRLLEQVVFKRVLTWLKKRKELGLELRQVAVNISAD
HFFHHSFIPHLVDRMAEYGIEHKWIQLEITERIGFVDIETAHQVFKKLNRYGFTSSVDDFGTGYSSLSYLQKLPVSEIKIDRSFISSMH-EHGTLAIVRT
IIQLAENLNMTAVAEGIETEQQRSILVSLGCRVGQGYFYYRPMSLEEANLL---------
>tr|W3ACS4|W3ACS4_9BACL Uncharacterized protein OS=Planomicrobium glaciei CHR43 GN=G159_15865 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------RKDGVPFWNEITVQPINVRKNTGAYTLMLQRDITDRKQ
TESLIKLQQETYNDIEKGYMLDDAKCTVMLVDENGRFRGSSMPKKFNEDGALV--E--ETGGTCGAAVENMLTDPLWN-GYQELVKSMNFVSSW--SVPI
FDTDGNPSGTFGIYFKPMLPTHQQTEILELAYVDKETELPNRNYFMNEVKEMLS----EHKEGFIAFISADEYVKVVDQYGHRAGDSLVREMGKRFLRSK
LADHLVARFSDSTIALFCLTP-L-KVPDYLEVLSQ--IDPINIEDMELFLTMKMGIALITPNQQDPNELIRHADSALSKAKLRAGESTCYYENEHDESMM
KDLRIANELTAALRREEIDVHLQPKVELSTGKIMSFEALARWNSPELGTIAPDVFIPVAEKNGKIRMLEQSLLKRVLSWLKTRQDKGLELSQVAINVSTD
HFFHHSFIPYLVDQTAEYGIEPKWIQLEITERIGFVDIETAYKVFKQLLNYGFASSIDDFGTGYSSLSYLQKLPVTEIKIDRSFINNMH-EQQTLAIVRT
IIQLAENLGMRVVAEGVETEEQKRMLLALGCRIGQGYFYYRPMSLDEANLL---------
>tr|A0A0B4RDS4|A0A0B4RDS4_9BACL Phytochrome-like protein OS=Planococcus sp. PAMC 21323 GN=Plano_2403 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------RKNGTPFWNELSIQPLTFPEKNLKFTLLLQNDITERKR
TEALVKLQKQTYKKIENGNKLDGAKCTVLLIDNERIYTTESMPKSFEEIGLKV--E--EDIGTCGAAVKDMTTDYLWR-NHQQLVEQHGLVSSW--SIPI
LSVEDEVVGTFGIYFATAIPYHQHEEILRLAYRDGDTNLPNRNYFRDEIDKLLK----IGKEGFVAFISTDEYTKVVDQYGHRAGDTLMTEIGRRLMLHQ
NSENLIARFSDSTLSMYSITP-F-KIPDYLEQLMHGFTDPIKVGDMELFLTLKIGVAIVMPHQKDSEELIRCSDSALSQAKLRTGEAICYFESELDEFLM
RDLRVANELTVALNRNEIAVHLQPKVDLETGEILSFEALARWTSPDLGVIPPDIFIPAAEKNGKIRLVEKSILEQVLGWMKKRADQGLKLRQVAINISAE
HFFHHSFVRNLMNMTSMYGIDPKWIRLEITERIGFVDIETANKIFKNLKYFGFTTAIDDFGTGYSSLSYLQKLPIEELKIDRSFVSNMD-EAGTLAIVHT
IIQLANNLNMHAVAEGIETEKERRILLSLGCKVGQGYLFYKPMSLDEAYLL---------
>tr|I4X6M4|I4X6M4_9BACL Phytochrome-like protein cph2 OS=Planococcus antarcticus DSM 14505 GN=A1A1_06172 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------RKNGTPFWNEITIQPLSFPERNFKFTLMLQHDITDRKR
AEALIKLQKETYTGIERGYMLDGAKCTVLLIDETELYKANSMPKGFLDSGLEV--E--EDIGGCGAATEDMSTDYLWR-NHQQLVKDYELVSSW--SIPI
MSVEGTPIGTFGIYFLPSSPHQQQEEILRLAYIDENTELPNRNYFRNEIIELLK----EKREGFVAFISTDEYVTVVDQYGHSSGDTIISEIGKRLMLSQ
NSEGLIARFSDSTLAMYSMTP-F-KIPEYLEHLLHGLVEPIVVGDLELFLTLKMGVAIVTPHQEDSEELIRCADSALSQAKLRTGESICYFESEHDEFMM
KDLRVANELSAALRRNEVGVHLQPKVDLATGKILSFEALARWTSPDLAIIPPDVFIPAAEKNGKIRLLEQNVLQHVLKWQKKRKDQGLELRQVAINISAD
HFFHHSFVPHLMDKTAEYGIDPQWIQLEITERIGFVDIETANKVFKHLKHCGFTTSIDDFGTGYSSLSYLQKLPVEELKIDRSFISNMN-EPGTLAIIRT
IIQLAENLNVRAVAEGIETERDRQTLLALGCKVGQGYLFYKPMPLNDANLL---------
>tr|K1KJI0|K1KJI0_9BACI Bacteriophytochrome cph2 OS=Bacillus isronensis B3W22 GN=cph2_4 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------RKDGYAFWNEVRHLPMFNQQGILQYCVIIMKDVTDSMN
IESLIELEREVYFSLETGHPLKKCHCSIVLVDEND-RMYGEM----WKKELDE--K--VLLMDMKDNLKDLEQSIYHE-AYRPIIDKYRIVSMW--SQPI
LNSEEKTIGLFTMYFQRAEPKDQKSAIHRLAFCDVASGLNNYERFKIILNDFTA----NQSMGHLYIIEPGEYQNIIDLYDRQGGDEVLRQLANRIQNIP
SADSIIARYTHSAIIVATRLS-LE--MKIPPIVAQFLSEPYYIDGKEVYLTLKIGTSSFSSRIN-YIEAVRQADIALSSALKVTGTVIKNFNMSLIESVE
QEMNVLAHFARGLKNSEFFPMLQPKVNLMTGEIESFEALARWNSTDLGVVSPTLFIPVAENTGNIYKVDLEIFKKVLLWQKQRHDAGLKLYQVSINISPS
HFYNPAFVESSIALIESYKVDPKFIKFEITESVELENVIRAKKIIDELQQLGIETSIDDFGVGYSSLSYLQELPFKEIKIDKSFVDNLA-NPRMNAVIKT
IIQLSDNLNMVSVAEGIETEEQHLELKRLGCQVGQGYYYYKPMLIEQINELLN-------
>tr|M3F9H7|M3F9H7_9BACL Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Planococcus halocryophilus Or1 GN=B481_09
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------RKNGTPFWNELSIQPLTFPEKNLKFTLLLQRDITERKR
TEAMNTLQKQTYKKIESGHKLDGAKCTVLLIDNERVYTTKSMPKSFEEIGLKV--E--GDIGTCGAAVEDMTTDYLWR-NHQHLVEKFGLVSSW--SIPI
LNMEDVAIGTFGIYFAPVIPSHQHEEILRLAYSDGDTDLPNRNYFRNEIDKLLK----KGQEGFVAFISTDEYTKVVDQYGHRAGDALMHEIGKRLTVHQ
NSENLIARFSDSTLSLYSITP-F-KIPEYLDQLMRGFADPIKVGDMELFLTLKIGVAIVMPHQKDSEELIRCSDSALSQAKLRTGEAICYFESELDEFLM
RDLRVANELTAALNRNEIGVYLQPKVDLETGEVLSFEALARWTSPDLGVIPPDIFIPAAEKNGKIRLLEKSILKQVLEWMKKRVDQGLKMRQVAINISAD
HFFHHAFVSNLLDMTTEYGIEPKWIRLEITERIGFVDIETANKVFKHLKYCGFTASIDDFGTGYSSLSYLQKLPIEELKIDRSFISNMD-EPGTLAIIQT
IIQLANNLNMHAVAEGVETDKERKILLRLGCKEGQGYLFYKPMPLNEAFLL---------
>tr|H2FYL6|H2FYL6_OCESG Uncharacterized protein OS=Oceanimonas sp. (strain GK1) GN=GU3_01080 PE=4 SV=1
---------------------------------------------------------------------------------RLKTLFMHVPILINGFNTE
GRCILWNDECERVFGWRFEELKQHPA--PIELFYPDPEE-RSGVIA-TFLKGSEFR-EWHPADRNGRRLWANIM----L-PNGD---MICVGHDITEQRA
LETQQRLAASVFEASYDGIVLTDANNSVIHINPSFTRITGYQPEDMIGRAATLFE-HDTDSQEGPTLPADLHSPAHWQGECTIRRRNGSRCALLLSVSVI
RDERGRVQHHAIILTDISHIKRHEAELRQRALYDSLTRIPNRQLFSELLERAMATATRDGTMLAVCYLDLDGFKQVNDSLGHAAGDRLLVEMGRRMALVI
RSCDVVARLGGDEFALMITGLHQLECTEILDRVLAAIDAPVRLDGHQARVSASIGVAVYPQDSKDGQTLLRYADKAMYEAKKQGKRRHVFFEPGLHAQDQ
ERHRLYEELHRALANDEFLLHYQPKIDLFSRRMMGVEALLRWQHPQKGMLTPAEFLPAVLDSDMEFELGQWVIRRLLQQMTVWLESGQN-YHASFNVSAG
QLLHDDFYSNLQYLLGLYAVAPERLELEFQETAVSGDIKRVAGVLEHCRRLGLTISLDNFGAGYASLVHLNSLPVDIIKIDRRFITDLLTSPTDVSMVEG
VVQLAAALSMVVVAEGMEAPELGERLQQLGCHYVQGYGISHPMPAEAIAGWLSEW-----
>tr|A0A0E2PHW1|A0A0E2PHW1_RHOCA Diguanylate cyclase OS=Rhodobacter capsulatus Y262 GN=U715_04090 PE=4 SV=1
--------------------------------------------------------------------------------ELLRLLIESTIDPVALTDTE
GRVVIANKAYAQPFGRIPAEIEGRR---RSQF-MDEQLA---RH-LNGLEAGALIVEESVLRPPPGTPRPAHLERRPVFDDDGAVIGVFTRARDVTEELR
TREVERLADRVFEQSSDAIVITDPGLRVMRTNPAFERMSGIAPGATPALLLDLVRSGTRWIMSETDSWLRVRAEGSWQGEVTLHGKDDRQLTCWARITRL
TDAAGVNLGHVAMLADLTLLRQTQADNQRMAQFDQLTGLANRRLLAERIDDWIGFASRAGQSFALMYLDLNKFKSVNDSLGHETGDLLLTVIADRLRAAL
TEGELAARIGGDEFVVLIGNADEAAALRRAAELLDHLARPLDLPLHNYRPSAAAGIACYGRHGDSRDALLRNSDLAMYAAKSDR-RAVMIYEPSMGAEAL
RELETRVALVSALENDEFELHFQPIFALDDKRPRGCEALVRWNRPGHGLVMPGAFLPVAAKAGLMPAIDRMVLRRAVAVQARWRWAGLVDWTLSINQTAS
SLAAQDWAEVLDAALVRVVAPPFGLQIELTEDQLAVDIPGAMEALQRLRKMGIALAIDDFGTGYSSLTYLRRMPVTTLKIDASFVRGIEADGDARQIVEA
IIGLAKKFGFVALAEGIESEAALQTLIELGCDYGQGYLFERPLPQSAFEARF--------
>tr|A0A0E2PXH2|A0A0E2PXH2_RHOCA Uncharacterized protein OS=Rhodobacter capsulatus Y262 GN=U715_05110 PE=4 SV=1
--------------------------------------------------------------------------------DLRRLLLDAFPDPVSVTDAD
GRVCLVNRAFLRANGRSEAEVIGQL---PQDF-LPLIEA---LH-AAQLDARGITLEQTRLRPPSRTGGWERLEKMPLFDDFGAVVGVVTRSHDVTEEVR
AREL---AEMVFDQSSEAIVLTDPDLRILRANAAFEQVAGFGQARLLGRLLELLMPGPGPASAPQDGWLALRARGLWRGEAVLRSSEGKSMICWSRITRL
ADASGRVLGHVAMFSDLTPLRQAQADNLRLANYDLLTGLPNRTLLGERIDGWIERAGHGGRGFAVLFIDLDQFKSVNDTLGHETGDMLLSAVAQRLRIGA
GADHFIARIGGDEFVLLLRDTGAEAAQRQALALLEALALPIDLPLHQYRPAATVGIACFGAHGDSRDVLLRNADLAMYAGKMSR-RTVMLYEPQMGVEAA
RELDLRHALAGAVERGEMVLQFQPLFGLHDRGLRGCEALIRWNRPGRGLITPGDFLPVAQRAGLMPALDRWVFGEATRTLCRWRKSGRVDWLMSINQTAA
DLAAPDWAEALTGCA---ACDCTGLQIELTEDQLADRVPGAVEALGRLRARGLRLAIDDFGTGYSCLAYLARLPVSMLKIDAHFVRGIEADRNARLIVEA
ITGLARRFGYATLAEGIETEAEAATLAAMGCDMGQGFLLAPPLSAAAFEARF--------
>tr|A0A0C5VRR9|A0A0C5VRR9_9GAMM Uncharacterized protein OS=Gynuella sunshinyii YC6258 GN=YC6258_05292 PE=4 SV=1
----------------------------------------------------------------------ESQNRLFTSEQAFRTLVENSPDAIARYDPE
GRRVFVNKALVELLGKSAEELVGKSP--LEDNLGGDDSR---GLYNGVAATKNRETLSICLNTKHFGKRYLDLILTPEFDRSGDINNILVVSRDITAHKE
IEEQLYRSETLVENSPDIICRYDCDRRLIYANPSLAKLVGKPVSELLGISPAMVEHGRLHVKVDEALFEVLKTGRNLSLETKILRQDGALVTALVRFVAE
YDRDGELVSVLAVARDISDIHEYRQQVNRLSYYDVLTGLPNRTHFNDKVNDVLTQAGEQSYRVGLMMIDLDQFKNINDSLGHGSGDYLLSKMAERLLDKT
GDGDIVARLGGDEFAILMPDNPSDIVRHKGQSILDVIREPLLVNDREISVTASIGACIYPDDCVCPSDFVSSADSALFHAKDSGRNTLCFYHSGLTIQVR
ERLELENDLRRALARNEMQLFFQPQIHLHSGEVIGAEALIRWQHSERGLISPDRFIHIAEENGFIVELGEWIMRQACMTALQLNRDRSNPLVISVNLSPR
QFADPEISAMVLQALSDTGCHPHWIELEITEGILMDRRYDVMKSLQDLKEPGISIAIDDFGTGYSSLGYLTRFPIDTLKIDQSFVSQMLESQQSAVLIRT
IISMASSLSMHTIAEGVETSEQAYKLATMGCEQAQGFYYGRPMSITQFERYLQR------
>tr|A0A078BJW5|A0A078BJW5_9BURK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thiomonas sp. CB2 GN=THICB2_660005 PE=4 SV=1
--------------------------------------------------------------------LRPLTQRLHQANARVQNAFDYSGIGILMVNGQ
GEILDFNPAFSEMLGYTPAELRQPH--VVDDFLHPDDRGAVAA-QLGGMADTGAYCAHRRYRHKNGRYRMLQWHVSPVKNEDGAVTSIVCYALDVTDELA
RDAAIRQTAAVLDNMRDVVYACDENGLLSYVNAAAIRKMGVSLRELELVTPVHTT--DHKPPLEQPLESALRGEPKEAENFLIESLEGQWRHYEITARRL
LDSTGTPLGAAAVAHDVTEIRAVDRRLKWLIDHDELTELPNQTLVIESLERLLEASRDESRQLAVYLLDIDRFRQINDSFGHALGDDLLIETAARLKVAL
APDDFLARWGGNAFAVLHPCTADQALLDHAEQLLNSLTEPFVLDGQTIFITASLGIARAPRDGRSATQLFSRADVAMYRCKANTPGRALLYTADMSQRGR
ELIEMETDLRHALAMEQFFVLYQPKVCLQTRQVIGAEALLRWQHPQHGLVSPATFIPLLEETGLIVPVGQWVLNAVCKQLQEWEQQGKTPLPIAVNCSMR
QLQGDLILRQVSSALEHSGIAPGLLELEITESMMLRDPEHVSGLIVQLRELGVNTSIDDFGTGYSSLASLKRLPVTTIKLDRAFVKDLPNDADDAAITRA
VISMAKALHLIVIAEGVETQEQADFLQQLGCEAYQGWLFSQAVAPKRFAQYLAD------
>tr|C8X1L9|C8X1L9_DESRD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfohalobium retbaense (strain DSM 5692) GN=Dret_1153 PE=4 SV=1
------------------------------------------------------------------------------EKARLRAALANSRQGVCEIDPE
ANAIYLDLNVWDHVKPSAKTKYRKS---FDNLIHPDDRQG---LLELPQADGQLRSC-FRFQSQSKEWRWLQFRGKTLPHSSGYP-VLIGTVEDITSEME
TAKNLEKSENLFANALEGMYLIGTDDSVICVNQAFADLLGYASPKDRGKKFRIYETPTVNKNKFNALWT---KGKIMHLETQVRRKNGELIWISENTKIV
KDDHKNILYLQGTIIDITERKKSEERLLHQALYDHRTNLPNRSYFVEKIEKGLKRVGQEGFSFGLLYFDLDGFGTINDSFGYFVGDRLLLEVSHRIRTAI
DETDTLARFSSDEFCVMSENRTSAQIQDLAENIRQKLEQVFFLDGQEITLTTSIGILEYNVTYTRAEDMLRDIELAMLQAKKRGKNRWVIFSSDMYQRKS
ERTLMEKDLRRALDREELVLNYQPIIKLDSGELNSLEALIRWKHPEHGFISPGKFIPLAEQTGLIEPIGKWVLKEACRQVKIWRESNKS-LIMNVNLSSK
QLEKAGLERNIYQILQDINLDPACLNLEVTESAAMSKLESNVRTLKRLKFMGIRLSIDDFGTGYSSLAHLQRFPLDELKIDRSFIISLKAGKACHRIVHA
IVELALGLKLKMVAEGIETNSQLNMVKTFNCHYGQGFLFSKAMAANEIEKNWFTVG----
>tr|C7R9T3|C7R9T3_KANKD Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Kangiella koreensis (strain DSM 16069 / KCTC 12182 / SW-125) GN=Kkor_2544 PE=4 SV=1
-----------------------------------------------------------------------------------NTVLNKAPIFLYTLDYR
TK-LFVEEYFSNLLGYTQEEFEAMPEG-VYSTVHPDDIPVVQE-QEQRLDDKDVIPADFRVKKKDGEWIWIQVHSTIYRDEDGNAIIEIGSIHQIQKDFK
TEQALRRKDTLVENSYDCILMYDRNMNVTYISPSVTRVTGYTEEDLIGKTLEMFEEDREEA--EANLRYVAENPGALSVERRINHKDGHILWIESRLVNH
L-GDPDIQGVTVNFHVITERKQAEQKIHNLANYDPLTQLPNRYLLRKRLLKGLADSVKNESKLALMYIDLDRFKEINDTLGHSVGDALLQTVAKTIHKCL
RSSDTLARVGGDEFTIVLPETSEKEARYIAERILQQFRTPFKADSHTVQTGASIGISIFPDHSKKAEDLFRFADIAMYSAKKE-RNQYQLYELRHSEREN
RRRSVEKKLKTAIANDHLRLYYQPRVDIKSGAIKSVEALCRWYDPDHGDISPSVFIPIAEESTLVHELSQQVTDLACKQLVSWRNMGID-TTVALNLSIK
DLRNFNLLNQFADTMRTYDIPGSALEVEITESAAMTDVVNTVKVLNQFKDLGIKLSIDDFGKGYSSLAYLSQLPVDNLKIDMYFVSQLSSQKQDRNIIRS
IISLAQSLDLHTVGEGVETIQQMSILQSLGCDMGQGMLFCRPMSATAITDLLREG-----
>tr|K4KP14|K4KP14_SIMAS Eal and ggdef domain containing protein OS=Simiduia agarivorans (strain DSM 21679 / JCM 13881 / BCRC 17597 / SA1) GN=M5M_18955 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------KRYWFDVDQVPTSDLSGAVDGVLLVLRDISESVH
VNRQLLESEAFISNCMDGIWCCQIDPP-VAVNLPFTECNRRAPSDLLGEKVFDQGLGVHRAEFVQSDYQL-VEAPSFR-----HMEDG--RRLELTVSTI
GVEQGQLVHVWGITRDVTERYHAMARMEYQAHHDSLTGLPNRHALYKTIRTTLDERAP-EQAMALLLIDLNRFKDLNDALGHQVGDSLLKQVGPRLREEL
SESDFIARLGGDEFAIFLPAIRNQQAVVAAHRVLDAIKQPYNIDGFHTEMGAAVGIALRSAQANDVSHLMRYADVAMYQAKSEYS-GVVVYSAAKDPNQG
LRFSLISELRRAIREQELLLNFQPKIELQSRRVHGFEALVRWQHPTQGFIPPAEFIPMAEATDVIHPLTEWVLEQSIRQCKQWHAQNFF-VTVAVNLSAR
NLLDEKLPHKVTQLLEKYQLPAVALELEITESAIVLDPDRALMILNQLSEQGVRISIDDFGTGYSSLAYLKKLPVNALKIDRSFVMDMLTDRQDEVIVKS
TVNLAHNLGLHVVAEGVENERTLQALAALGCNQAQGYHLGRPMPEGQVLDWFRASP----
>tr|A0A031IBU6|A0A031IBU6_9BACL Diguanylate cyclase OS=Exiguobacterium sp. RIT341 GN=BW42_02844 PE=4 SV=1
----------------------------------------------------------------------------------YEVVIQEFPLPSFILNID
LTIRSWNELAEQHWGWTQQEIVGQI---V-PLLDQEDMA-F---SHQIWHSFSVQLPNASLFHKSGTPMTSTLLLSPLLDVGNAIAAFVCCIPITKPLFQ
GLMDLR---QAFDQIA-SVAVFDARGAITYINDQLMDVTGYCPEMLIGQPWSILDQTSATV---SEIRTQLRERKAWSGRLSLTSHTGERKHLQATLIPI
YDANGVRFQHLFIGNDITETTVLEEELDFLVHHHEMTHLLNKRGFLREGEALFQSAASH-EPIALILFDIDRFKVINDSFGTHVGDQLLQAMATRLLEHT
-TGVLAFHPTSDLFGVLLPAPSSNLLFQYARKLQQALQRPYYINGHSLIVSCTFGITVYPSEAKTLEDLYRRSETALYAGKSIGTGTIQYLTHEMDTQFT
RKIQLERSLFTALEDQSLYLAYQPIIELQSQAVKGFEALLRWNHTALGNIPPDEFIPLAEEASLITTINNWVIIEACEQLAKWQQTIDPELTMAINISPH
QFQSDSFIRTLQHVVTERLVSPSSVTLEMTENIAILQTQRTVERMHLIKSLGFRLSIDDFGTGYSSLQYLSAFPIDELKIDKVFIDGLAK--NDHALLDS
IIQLGRNLELNLVAEGVETEHALTYLKTTDCQYMQGFIFSEPLSVQDVEKRFLT------
>tr|B1YJ55|B1YJ55_EXIS2 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Exiguobacterium sibiricum (strain DSM 17290 / JCM 13490 / 255-1
----------------------------------------------------------------------------------YETVMQGFPLPAFILHVD
LTVHSWNEAAESCWGWSAQEVTGQL---V-PLLDPEDAA-F---SRQIWYSFSMQLPNTTFLHKSGDRSTSTLLVSPLFDKNEPSGAFFCQLPNTKPLFQ
GLMDLR---YAFDQIA-CVAIFDARGTIQYANTNLTDITGFCPHLLLGQPWTLLDSSEDVL---PMIRSQIKKKKAWSGKLSISTQDESKKVFHATLIPV
YDVNGVRFQHLFIGTDITETEHLEQELDFLVHHNELTHLLNRRGFLREGQVLFSKASDD-LPISLILFDIDRFKVINDSFGTHVGDQLLQALAKRLSEHA
-KQLLTFHPTSDLFGVVLEVTDRNALFQYARKLQQVLQRPYYINGHSLIISCTFGITVYPSEAKSLEDLYRRSEMALYAGKSIGTGTIQYLTHEMDEQFT
RKLQLERSLFTALEDQALHLVYQPIINLKTKHVDGFEALLRWNHTALGSIPPDEFIPLAEEAALITPINNWVVIEACERLALWQKQIAPDLTMAINISPH
QFQSDSFVRTLQHVVSQKKIDPRFVTLELTENIAILQTQRTIERMQLIQALGFRLSIDDFGTGYSSLQYLRAFPIDELKIDKVFIDGIDL--GENGLLDS
IIQLGQNLKLNLVAEGVETTTALSYLEATACQQMQGFIFSEPLSVEEVELRFGS------
>tr|K0A8E4|K0A8E4_EXIAB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Exiguobacterium antarcticum (strain B7) GN=Eab7_0480 PE=4 SV=1
----------------------------------------------------------------------------------YETVMQGFPLPAFILRVD
LTVHSWNEAAESYWGWSAQEITGRL---V-PLLDQEDAA-F---SRQIWQSFSMQLPNTTFLHKSGEQLTATLLVSPLFDQNEVIGAFFCQLPTSKPLFQ
GLMDLR---YAFDQIA-CVLVLDARGTIQYANTNMTDLTGFCPQTLLDQPWTLLNSSEEVL---STIRSQIKQKKAWSGKLPILTNGDQEKVLQATLIPI
YDVNGVRFQHIFIGTDITETEQLEQELDFLVHHHEMTHLLNKRGFLREGNTLFSEATDQ-TPISLILFDIDRFKVINDSFGTHVGDQLLQALAKRLSQHA
-EQKLTFHPTSDLFGLLVEVTDRNVLFQYARKLQQALQRPYYINGHSLIISCTFGITTYPSEAKSLDDLYRRSEMALYAGKAVGTGTIQYLTHEMDEQFT
RKLQLERSLFTALEDHSLHLAYQPIINLKTKQVDGFEALLRWNHTALGSIPPDEFIPLAEEAALITPINNWVVLEACEQLAKWQERISDDLTMAINISPH
QFQSDSFVRTLHHVVGQKKINPRFVTLEMTENIAILQTQRTVERMQLIKSLGFRLSIDDFGTGYSSLQYLRAFPIDELKIDKVFIDGIDS--GENGLLDS
IIQLGRNLNLNLVAEGVETASALRYLEATACQQMQGFIFSEPLSVTEIEERFGP------
>tr|A0A069EZ72|A0A069EZ72_9BACL Diguanylate cyclase OS=Exiguobacterium sp. AB2 GN=DI14_11225 PE=4 SV=1
----------------------------------------------------------------------------------IDAFIDALSIPCCYIDLG
GDVLLWNEHATALFGWERDEVLHQA---L-PVVEQLDSA-L-----ETWAPLFSTTAMTPFQHKDGSLVYATAYLQSF--IAGYTGYFLAFLPLSTEQFN
LLHHFQ---AMIEQTT-YYLSADADGRITAVNPMLCELIGESEHRFIGLDWFLVHPMHEKAPIADTVRAALSSDRIWHGEMPIQSKRHTTCWLNLTVVPI
LSEQGEVLQYTAFGFDVSDKKRLEREVEYLAYHNDLTGLLNKKGWLREYRDILQLADQSEGIVHIALFDIDRFKIINESFGSRVGNELLLQIKERASRHL
PDTSVMFHPSGGLFGVLFLEQSKEDVFRLLRQLQYELQRPFRIYHHSIMLSISIGCVFYPSATNSLEELYARAESALFKGKRIGVGTIQFVTKDMDDAFS
RQIHIEKALYQALEEKHFYLEYQPKYELKTDRLIGFEALLRWHHDELGQIPPSEFIPLAEEMALIVPINNWVILEAAKQLKVWQPLVDHSLSMAVNISPN
QFRSESFINTLRNIKQQLHLNPTDMILEITESLVMQQTEEIIARMNQIKRLDYRLSIDDFGTGFSSLQYLKSFPVDELKIDKVFLDDWLA--SKSHLIDV
IVHLGKSLNLHVVAEGVEDEEMLDHLRTTDCDSFQGFLYAKPMPPERVIELLTH------
>tr|C4L2E6|C4L2E6_EXISA Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b) GN=EAT1b_2276
----------------------------------------------------------------------------------VDEFIDALSVPCCYISQD
GTVLLWNTHAEVLFGWERDEVLHQP---L-PVVRQLDHA-L-----ETWSPLFSTTAMTPFQHKDGSVIYATAYLQSF--LEGIYGYFLAFLPLSTEQFN
LLHHFQ---EMIKQST-HYLATNAKGEIVDINPSLCRLLDATEQQLIGREWFLIHDSSEQDGISRNVLKSLATNRIWNGEMPISCKQHESCWLNLTVVPI
VSEKNEVIQYTAFGFDVSEKKRLEKEVQFLAYQNELTGLYNKKGFLRRYDSILRQIDEREGLLHIALFDIDRFKIINESFGSRVGNELLIQIKERALHLI
PESALLFHPTGGLFGVMFFEESKEEVFQVLRHLQHELQRPFRIYHHSIMVSISIGCVFYPSSTSSLEELYTRAESALFKGKQIGVGTIQFVTKDMDAAFS
RQIHIEKAMYRALEEKHFYLEYQPKYELATDRLIGFEALLRWHHDELGQIPPSEFIPLAEEMALIVPINNWVILEATKQLKAWKAEFDQPLSMAINISPN
QFRSDSFLNTLRNIKQQLQLDPADIILEITESLVMQQTDEIIERMEQIKRLNYRLSIDDFGTGFSSLQYLKSFPVDELKIDKVFLDDWMA--SKSHLLDV
IVHLGKSLNLHVVAEGVEDEEMLAHLKSTDCDSFQGYLYARPASPSAIEQLLRS------
>tr|A0A099DDQ6|A0A099DDQ6_9BACL Diguanylate cyclase OS=Exiguobacterium mexicanum GN=JY98_13660 PE=4 SV=1
----------------------------------------------------------------------------------IDEFIDALSVPCCYINLD
GNVLLWNEHAETLFGWERDEVLHHP---L-PVVQHLEHT-L-----ETWSPLFSTTAMTPFKHKNGSVVYATAYLQSF--INDFTGYFLAFLPLSTEQFN
LLHHFQ---AMIEQST-YYLAANAYGEITEINPLLCGLIGAPDHQFIGRNWFLIHPSFENDPIAEDVLQALTTDRIWNGEMPIRSERHTACWLNLTVVPI
LSEEGEVVQYTAFGFDVSDKKRLEQEVNYLAYHNDLTGLLNKKGWLRQYAHVLKTVDQGDGLVHVALFDIDRFKIINESFGSRVGNELLVQIKDRATQFM
PETSVMFHPSGGLFGLLFFEESKEEVFQLLRQLQHELQRPFRIYHHSIMVSISIGCVFYPSATSSLEELYTRAESALFKGKRIGVGTIQFVTKDMDDAFS
RQIHIEKALYQALEEKHFYLEYQPKFELKTDRLIGFEALLRWHHDELGQIPPSEFIPLAEEMALIVPINNWVILEAAKQLKAWQRLVDYPLSMAVNISPN
QFRSDSFINTLRNIKQQLNLNPSDIILEITESLVMQQTDEIIARMNQIKRLDYRLSIDDFGTGFSSLQYLKSFPVDELKIDKVFLDDWLA--SKSHLLDV
IVHLGKSLHLHVVAEGVEDQEMLDHLKQTACDSFQGFLYAKPMPPIEVVRLLTG------
>tr|S3GH58|S3GH58_9BACL Sensory box protein OS=Exiguobacterium sp. S17 GN=L479_01706 PE=4 SV=1
----------------------------------------------------------------------------------IDAFIDALSIPCCYIDFD
GTVLLWNEQAETLFGWERAEVLHHA---L-PVVQHLEQA-L-----ETWSPLFSTTALTAFKHKNGSVVYATAYLQTF--INGVNGYFLAFLPLSTEQFN
LLHHFQ---AMIEHST-YYLAANARGEITEINPLLCDLIGAHDQPFIGRNWFLIHPSFEDDPIAGVVRQALTTDQIWNGEMPIRSQRHVTCWLNLTIVPI
LSEDGEIAQYTAFGFDVSDKKRLEQEVNYLAYHNDLTGLLNKKGLLRQHAHSLTDVKEQNGLLHVALFDIDRFKIINESFGSRVGNELLLQIKDRAKRFL
PQSSVMFHPSGGLYGILFFEQSKEEVFQLLRQLQHELQRPFRIYHHSIMLSISIGCVFYPSATNSLDELYTRAESALFKGKRIGVGTIQFVTKDMDDAFS
RQIHIEKALYQALEEKHFYLEYQPKFDLKTDKLIGFEALLRWHHDQLGQIPPSEFIPLAEEMALIVPINNWVILEAAKQLKAWQPLVNHPLSMAVNISPN
QFRSESFINTLRNIKQQLDLNPSDVILEITESLVMQQTEETIARMNQIKRLDYRLSIDDFGTGFSSLQYLKSFPVDELKIDKVFLDDWLT--SKSHLLDV
IVHLGKSLNLHVVAEGVEDQVMLDHLKETDCDSFQGFLYAKPMAPDQVVRLLTN------
>tr|G4QKV6|G4QKV6_GLANF Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Glaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064) GN=GNIT_1219 PE=4 SV=1
-------------------------------------------------------------------------------SERLKLALKAGQLGVWEFDTK
TGKISWDERMFDIFDVKPAEFTGQFSD-FINTLHPDDKERTIQIFADSLEKKQSMAFDFRIIDSHENIRHLSGTSEIIQGSNGEPDICVGINQDITLQKN
AKQLLLDQHNFVSAM--PVAVFSVVNNSITINKRGEHLTGYSKTELSRVEDNCLFSGKLEPDFYESVTRNLQSKS----TMQIQHKDGSRRWITFEGCNL
AD------RQAWVMIDMTEQVNAEKELKKLAFFDSLTGLPNRHSIEQKLIALVDIAKSTGTLFGILLIDLDSFKNVNDNYGHIVGDQLLTRVSRRLKKRL
REDDTLGRIGGDEFMIIVRNIRDDKLISIANSFIDAFTTPVVLNSLSLNVTITIGASLYPIHGEDYVHLFRNADTSLYHAKAEGKNRAQLYQSEFTTSLK
TKLELEANIELAIANQAFSLHFQPIVNCSNNQILSAECLMRWFHPELGYITPDKFISAAETTGQIVRLGRWVIRESFKEFVKWQQNGIELEYLAINLSPV
QFNDGSLINDISIALAETGINPKSIVFEITEGMLVHNQSYTSNILKKMKKLGIRLAIDDFGTGYSSLAYLKYFDVDILKIDRSFIMDIPDNPQDMQITGA
ILSMAQDLNLKVVAEGVETEGQLAFLKAHNCNTYQGYFKSPAISGDEFVALFK-------
>tr|K9TNS4|K9TNS4_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Oscillatoria acuminata PCC 6304 GN=Oscil6304_4244 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------RLFGYSSQEVLGQT---SDLIVPPERRSQIAQL-LQRLTQGDLNASINENLTKSGQTIICEWYNTPLFKHPGRFAGILSMVQDITDRWE
SELTLQSVNTLLNAINEVVLLFDARGCYLKILPTDSPLLERAASQLVGKTLEVFESTLADR-FLDYIQRTIQEQKSCNLEYELTLGDR-LVTFSAKLSPL
---NGD--RVLWVARDITDRKHIQALLRRYAFTDPLTGLANRCSFVKRLGTAMHNAYNHSPKVAVLLLDIDRFRIVKYSLGHWVADRLLVATAKRLQSCL
NPGATLARIGGDEFAILLTDITTADVIQLADRIQSAMRFPFSLDEHEIFSSVSIGIALDNGGYARSGELLRDADTALHYAKQQGQGQYVSFAQDMHEGAI
ARLQLETELQRAIARQPFQVYYQPIVSLSTGNIVGFEALVRWHHPIRGFISPGEFIPVAEETGQIGAIDRWVMNEACRQLGWWQQRYPADLTMSVNVSGV
NFAQVGIIERIEQTLRSSGICGRYLKLEITESVIMKNTGAALALLDRIKALGINLSIDDFGTGYSSLARLHELPINTLKIDRSFVNRMRGLDESSDIVQT
TIALAHTLGLDAIAEGVETSQQVELLRTLDCDYAQGYFFSKPVDSEAALNL---------
>tr|M5TNX2|M5TNX2_9PLAN Sensory box/GGDEF domain/EAL domain protein OS=Rhodopirellula sp. SWK7 GN=RRSWK_00282 PE=4 SV=1
---------------------------------------------------------------------KQFETELCRHRDFLNNVISAVPDQLSVRSSD
QRLVLANDAFCEAHSLTRSDAVGRKMDLLESYAFPENAG-------HPMAPASNDAIEESFVAADGSSRIASIKHSTFSDATSGESYLIATSRDITEDRR
REDRLRVLASVFNSASEGVAILSSDGLIREANPAFVSMLGVPSLEATGLLDRFCDAMQIDAGLFESTLSDLNSGTPWSGKATVKSDANRGHAVWISLSPS
HFRDTSSDEIIALVSDITELENSQIELHRRAMHDSLTTLPNRVYFREELSRLVRLDQSPHDGLSVCFLDLDDFKLANDSLGHASGDQLLCLVGERIQKNM
GDKTFVARFGGDEFALIMQDKHLEQQYRLLDQLIRSFREPFRLDGDEARIGLSIGVARCPEDSSDADVLMRNADIAMYAAKNAGKNLVLEFTHEMQDGVD
LRHQVQSKLRRALSNGEIDVHFQPKINATTHELVGCEALARWKTSDGNYISPAEFVPIAEQTGLVTGLGDLVFELAAERAFRWHESGLI-PKIAVNVSPH
HLRHPRFLMTLESTLRKSGAKAEWFELEITENAMMENVDHAIDMIRHLGEMGFTVAIDDFGTGYSSLSYLKSFPIDTLKIDLSFIRDISTDRQSEAIVRS
IVSLGAGLDLDVVAEGVESVEQLEILESMGCPMVQGYLISRPLPENEYLAWVRN------
>sp|P55552|Y4LL_RHISN Uncharacterized protein y4lL OS=Rhizobium sp. (strain NGR234) GN=NGR_a02630 PE=3 SV=1
--------------------------------------------------------------------CRTAEAALQASVEHHRSLTELHPQVPWTADPS
GEVLEIGPRWEK-TGYAPKEALGAG--WA-KAMHPDDLGEVQREWAKSLATGEPLDVEFRLAAAEGGYSWYRSRAATRRAEDGSILRWYGTVEDIDDRRK
MFEALKESEAIADDAPVMIWVTGENGADDYHSRLWLETTGQTAEQAAGKGWNAVHPDDRNRVFYQAFD--LR--EPVRMEYRLKRAGGGSAWVIDIGQPR
FASDGTFLGFVGIALDITERRNAEKQIHHMARHDALTGLPNRQFLREEFERLSDHIA-PSTRLAILCLDLDGFKAINDAYGRATGDLLLRHVTERLRNFL
KQSDILCRLSGDEFVVLRVGINSAEARLLAQQLIDVIEAPYELAGTHVDLQVVVGLAAASKSDQSLDELIKTADIALERAKTGGGGTIVQYEPKMDADLR
ARQRMKVSLRHALAKGELEVRYQPLANLRTGQITTFEALARWPHPERGQVSPAEFIAVAEETGLIGPLGEWILRQACTEAVKWP----PYVSVAVNLSPL
QFRNQRLASTVRNSLEDTGLDASRLQLEITESVLLEECDSNLQTLKEIRQLGVIVAIDDFGTGYSSLSYLRTFPFDKIKVDRSFIADLPKSKESLAIVRA
VAAIGRSLGIITTVEGVERQDQLDTIKAEGFDEAQGYLFGGPLPASQAMALLKS------
>tr|B9R245|B9R245_LABAD Putative uncharacterized protein OS=Labrenzia alexandrii (strain DSM 17067 / NCIMB 14079 / DFL-11) GN=SADFL11_4225 PE=4 SV=1
------------------------------------------------------------LMISEAKKFSVEHKALKSTLFLTDLARSSAGIAVWRFDMA
ANRLTWDDAMFRLFDVDPGSFNGEFNDWE-RTVHPDDIDAARRQFLEAYEKKSGFATDFRIVRRDGSIHWLAAHCSFLEDDDGNVTEAVGVNWDITDSKE
MADSLFEREVTLASVVQGVSAFDKDGRLHFCNDRAGEFTGLP--------PEMLVPGTSYHAYNQ-YRQGAFVTGF-PGEAT-KAVSESVQPTSHIRSLI
HLSNGRIGGWVETYEDVTEKVVADERVKKAAETDNLTELANRLSFRETLDHVVDIAGDADVASSLLLIDLNDFKAVNDSHGHVVGDRLLQHVANTLKAVS
EGGDLAARLGGDEFALVLKPRTEEDIREIANGLCAVFDLPVNLDGLMVQSGLSVGVAIISADGTGSEETLSRADLALYKAKQEKRSAYRVFDADIAKEDA
ERKRTKNALIRVVENQGLDVFCQPILNLETHRVDHFEALVRWHQGEESYVPPSNFIPLAEEIGLIAKVGDFVLSEVLRSLATWPN----DYRACVNVSVL
QLGDGRFVERVLNGLKEAGISPHRLELELTESVLMSAGSAAHEDLRKLRDAGLNLALDDFGIGFSSFGYLQELPFNKLKIDRRFVSEVEKDEGSAAILRT
IAALADNLDMKSTAEGVETAQQLSVVTACGCHYGQGYFIGQPIPLEDVQQAYF-------
>tr|M9X521|M9X521_MEIRD PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Meiothermus ruber (strain ATCC 35948 / DSM 1279 / VKM
--------------------------------------------------------------------RYRAEQAVRQSEQMLRQITDAMQDVVALTDPR
GYFRYLTPSVERLLGYRPEQMLGQL---AFDYLAPEDREKAMRLAEQSLAGAGSYQLEGRYRHAKGHYVWIDTLVTYIYDGEGRLVGSVVSGRDVTERRQ
AEEALREREQITNSIRDVVVLLDPLARVQYVTPSVEQILGYRPEELVGKPISMLAGKAQWAEIRRRGLQAIREKRVYSTECGCKHKDGHVVWIESLVNFV
WDDAEALQGIVVGMRDISERKQQQAYVEYMAYHDELTKLPNRRALRRAAEELLSRASQREIPVSLLYLDLDNFKTVNDTLGHDVGDELLVEVSQVLSKQL
RAEDMLARLGGDEFACILFNTDTEQARQVASRMSRAIRSALGPAHKLPSLGVSVGIASFPKDGRTFVELLKVADIAMYQAKGSGSRVV-VYDPAKSPYTE
ERLQFEAAMRKAVQEQQLQLLYQPIWHLRERRIEEAEALLCWPYQGT-ILRASEFVPLAEEVHLVEQMDWLALQKGLMQLKLWHERGYL-YRLSINLSTQ
SLVQPEVMRELLALLKDAALDPQWLTLEVTESVLLREPEQARAALEGFKALGVQIAIDDFGSG-------------------------------------
------------------------------------------------------------
>tr|I3ZJG2|I3ZJG2_TERRK PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Terriglobus roseus (strain DSM 18391 / NRRL B-41598 / KBS 63) GN=Terro_3151 PE=4 SV=1
--------------------------------------------------------------------------------SLLYEVLHSTSDGIFLLDRD
WRFVYLNPCAIELLSGG-KALVGRN-VWE-AFEAASSLEFW-DKYHTTMEQRVPTEFEAYYPAP--LDRWFQVHAHPISQ------GISVFFRDITERRG
ETVRLRLLEQTVDAAPIGIALSEYDCPLIYVNPAFERLTGYSAEEVLGTDCRFLQGSDLGQPGGSTLQSAIANGCSGKAVLRNYKKDGTRFLNEVHISHV
RGSDSKVSHIIGLQYDVTEQLETREQLAKQARHDALTGLSNRHALLEHLETTLAHAKASGRPVAVVVLDLDNFKHMNDRFGHIETDRILVHVSRRIASFA
-GVQTAARLGGDEFALILSQWNDTDLGKLVEQLLHEISKPLPLGSKEILITGSAGIALFPQDTVEPEELLQMADVSMYAVKRRGKNSFRFYTADLRFNQN
EPLDVAVGFRRALANSEFELYYQPRVNASSKRIIGCEALIRWNHPDRGTLLPAQFIRIAEDTGLINEIGRWVLEEALQQNASWRRSGFQSALISINVSPS
QIRDPNFPAIVQDALARYRLPGTSLELELTESLLIDNGELAESSLRLLKKLGVRIAIDDFGTGYSGLQYLARFPIDTIKIDQGFTRNITSDHLSATICKS
ILTLGRDLGLTTVAEGVESVEQAELLRSWSCKELQGHLFGKPWPRNMAERAFQ-------
>tr|A0A085PFP9|A0A085PFP9_VIBCL Diguanylate cyclase domain protein OS=Vibrio cholerae GN=DA89_2120 PE=4 SV=1
---------------------------------------------------------LSIMALR----QYNYIQRLRTNQKLLESIFDQSTHYIGIFDLE
GRIVSCNGKLQGLLYRHGESLLRPI--WQHKGWEDSAVEHIQNYFSESV--PQTRQFNAEIWHPELGAIVLECQFKPLPT-RE-ESQILLEAQDITWRKI
TEDKLFQREHYYDQQPVMMLTLDERNHIQQVNHFAEQLLGYPADVMLGHHIRDFYQDE-EVLTPRQMLLSRHASSVWRREVCYRHHSGETVWVRENIRPL
VE-MG---TLLIVGEDITETRQLADQLAYQARYDLLTHTLNRNQFELELAKALKETESQLRTHAMLYLDLDQLKVLNDTAGHDAGDGAIQFCASMLEDVL
PFKATLARMGGDEFSVLLRDCTERDAVLVAQSIIHALEVAFVWEHIRFNLTCSIGIRMIDHTATSPQMVHAQADTACHAAKEEGRNRFNLYRQDDEDLRR
RQLEMESVVHDALANERIELFAQRIVPLNQDVLLHFEVLVRIKNAAGEYVSPGIFVPASERYNL----AHRLDRKIVEQTFNWLEARPKLGRVSINLSGN
SIGNPDFVAFLLERLRYSRIPCSKVCFEITETAAMRNLNQAINVLSQLKSLGCVLALDDFGSGLSSFGYLQKLPVDIVKIDGIFVCDMDKNEMDRLMVRS
IHELTKQMGKSTVAEFVENQQILEALQQIGVDYAQGYLFSRPQPIADWVAEQLK------
>tr|F0LQL4|F0LQL4_VIBFN Sensory box/GGDEF family protein OS=Vibrio furnissii (strain DSM 14383 / NCTC 11218) GN=vfu_A00387 PE=4 SV=1
---------------------------------------------------------LLYYLVR----LRNSERQIRDHQRLLESVFEQSNHYIGIFDHQ
GGLISCNHKFQELLYRQGVSLEQPL--WQHPHWEDASAERIKAYFEEVS--TQPRQFEAEIWHADQGAIVLEWAFKPMFN-MPGPIQYLCEAQDITWRKI
TEDKLFQREHYYDLQPVMMLTLDEQNRIQQVNRFAEQMLGFDASQMLGHRLKEFYLSE-QALSARQMLQNQSLQGVWQREIEYRHADGHAIWVRENIRAL
VE-TG---HLLIVGEDVTPTRKLADELAYQAKFDLLTNTYNRNQFELELAQALQETETELRTHAMLYLDLDQLKVLNDTAGHDAGDGAIQFCASMLEEVL
PYNAVLARMGGDEFAILLKDCTERDAIQVAKIIVATLEHAFWWDDIRLNLTCSIGIRLIDHTATSPQMVHAQADTACHAAKEEGRNRYNLYRQDDADLCR
RQLEMESVVHDALAKDRVELFAQQILALSGDAGMHFEILVRIKNAAGEYVSPGIFVPASERYNV----AHLLDKQVVEQTLRWFETRPHLGLCSINLSGH
SMGNAEFIDTLLARLQRSDVPCEKICFEITETAAMRNLNQAIDLFSRLKQLGCRIALDDFGSGLSSFGYLKKLPIDIVKIDGLFVRDIDVNETDHLMVRS
IHDLARQMGKQTVAEFVENEAILQRLREIGVHFAQGYQIGKPQPIDELVEQLLT------
>tr|A0A090P622|A0A090P622_9VIBR Diguanylate cyclase OS=Vibrio ponticus GN=JCM19238_2982 PE=4 SV=1
---------------------------------------------------------LIYYLSR----LKKSEQLARDNQTMIEMVFDQSYHFIGIVDHT
GLLIATNSKLQSILYQDDALSDLPI--WQYRHWQKEAAARIEQYFAELN--SSVCQFEAELYHPEQGAMVLELSLRVLPK-HEYKPRVMLEARDITSRKL
TEERLFEREYYYNQQPVMMLTLDEQNRIQRVNSFAEQLLGYHEKELLGHRLKDFYVDP-KATIPRQVLQKQALQGVWRREIEFRHRDGHSLWIRENIRPL
AD-SG---QILIAGEDVTEMRQLAKQLAYQAQHDLLTDTYNRNHFEIELDKALKEVESYTRTHVMLYLDMDQLKVLNDTAGHEAGDAAIQFCASMLQEVL
PYNATLARMGGDEFAVLAKDCTERDAKNIAHSIIATLENQFIWDEIKLNLTCSIGIRLIDHTATSPQMVHAQADTACHAAKEEGRNRYNLYCPDDAELRR
REMEMSCVVHSALADNRIELFAQRIMGLDIDQRMHFEILVRIRDANGEYISPGIFMPASERYNI----AHLLDKQVVRQTLAWLESHPNLALCAINLSGQ
SMGNQEFIAFLLDALNRSQVPCNKICLEITETAAMSNMKQAIELFTQLKQLGCLIALDDFGSGLSSFGYLKKLPVDIVKIDGLFVRDIAHNEMDHLMVRS
INDLAKQMGKRTVAEFVENSQIIDLLVELGVDYAQGYVIGKPKPLASLVDELML------
>tr|A0A0E2KH46|A0A0E2KH46_VIBPH Diguanylate cyclase domain protein OS=Vibrio parahaemolyticus VPCR-2010 GN=D051_4531 PE=4 SV=1
---------------------------------------------------------LSYYLQR----IRRSETAARESQAILESIFDQSMQYMGILDKH
GLLKSGNDRLQSLLYHQELRLDKPL--WLHQNWSEQARHAIADYFDAPQ--QQVSTFEAEIWSKEHGSMVLEISLKPFSQ-QVGQKQYLFEARDITSRKL
MEDKLYQRENYYEQQPVMMVTLDSHNRIQEVNRFAQLLLGYEPIEMLGHRLREFYLDD-KALFPRQVLQSHQVHDVWRREIEYRHADGHSVWVRENIRPL
ND-SD---QLLIVGEDISETKLLAEKLEYQARYDLLTGTYNRNHFELELKTALREVDSHRRVHAMLYLDLDQLKVLNDTVGHDAGDAAIQFCASMLEEVL
PYNSVLARMGGDEFAVLLKDCDEYGAINIAKVIISTLEHLFIWEDTRLFISCSVGIRIIDHTAETPQMVHAQADSACHAAKEQGRNRYNLFSLDNEELQR
RQMEMQSVVHEALSNQRLELFAQRVMNLQSESLMYFEILVRIRDAQGNYVSPAIFIPASERYNI----AHWIDKQVINQALEWFEQRPKLGRCSINLSGQ
SMGNQEFIDFLFERLKNSTMPCEKICLEITETAAMGNLDQAIDFFSRAKSLGCMIALDDFGSGLSSFGYLKKLPVDIVKIDGLFVRDIDVNEMDRVMVRS
INDLAKQLGKVTVAEFVENEQVMQHLIDLGVDYGQGYGIGHPKPLAELVENLSS------
>tr|K5VY09|K5VY09_9VIBR Diguanylate cyclase domain protein OS=Vibrio sp. HENC-02 GN=VCHENC02_4722 PE=4 SV=1
---------------------------------------------------------LSYYLHR----IRRSESIARESQTILVSVFDQSMQYMGILDQH
GLLKSGNDRLQSLLNHQDMRLDRPL--WHHKNWSEEARQLLANYFQSSH--RQVSTFETEIWSKEHGVMVLEVSLKPFSQ-QVAQEQYLFEARDITSRKA
MEDKLYQRENYYEQQPVMMVTLDNNNRIQEVNRFAQQLLGYQPLDMLGHRLREFYSDE-KALIPRQVLQQQVMHGVWRREIEYRHADGHRVWVRENIRPL
RD-SD---QLLIVGEDITETKKLAKQLEYQARYDLLTDTYNRNYFELELQTALREVESHRRVHAMLYLDLDQLKVLNDTVGHDAGDAAIQFCASMLEEVL
PYNAVLARMGGDEFAVLLKDCDEHGAINVAKQIITTLEQLFRWEDTQLFMSCSVGIRIIDHTAETPQMVHAQADSACHVAKEQGRNRYNLFSLDNEELQR
RQLEMQSVVHEALSSKRLELFAQRIVNLSGGSPLCFEILVRIRDAQGNYLSPGVFIPASERYNI----AHWIDKQVITQTLEWFEARPKLGRCAINLSGQ
SMGNQEFIDFLLERLQSSSIPCEKICLEITETAAMSNIDQALGFFTRVRTLGCLIALDDFGSGLSSFGYLKQLPVDIVKIDGLFVRDINVNEMDRVMVRS
INDLAKQMGKVTVAEFVENDQVRELLIELGVDYGQGYGIGHPKPLSELVDELQQ------
>tr|M5A4F6|M5A4F6_9ACTN Uncharacterized protein OS=Ilumatobacter coccineus YM16-304 GN=YM304_34090 PE=4 SV=1
---------------------------------------------------------------------------------------------MGLADEH
SDGIDEHDERGALVSVDGEVL-------AANRWLDVAVGD--PLFREEL--DH-------IVPLRSGVDGARWRARPIDE-RG---DVLLA---------
TQEHEDAGDRFFANGDALFVVYDQAGLIIESNAAWEELLGYTTEEIFGIDSWSLLPDD-EVSDRERV--ERELREDGRSETCFRTADGSYRRVRWTLQFD
IS-VG---RCFGIGRDVTEEDMVTAELEHRATHDELTGVANRSQLVAHLDEVI----DAGGHPSLLFCDLDRFKVVNDSLGHLAGDQVLAQLAQRIDSDL
GDDALVSRFGGDEFIVMLDDGGEARARLVAARLLDCLERPFEALGRTVHLTMSIGICFQNKENLTVDEMLRDADRAAYEAKSLGRKRCVIFDEGLRDEAE
RRFEIEAGLRRAFDHGEIVAHFQPIVSVPDGEIVGAEALVRWQ-TPEQLVLPGEFLDVAADAGL----LPRVSRLVISATVAAAERL-RPLQMSINVSDP
ELHIAGFAADLIDRVARADLDPSMFLIEVTESMVL-TTGRAIEVLGELRAAGFRIALDDFGTGFSSLAHLRELPVDVVKVDRTFVADLLDDEVAYAVTTS
LVTLCDALGLDVIMEGIETPLQASAVELIGCRLAQGFLYHHAMPISELERLVGS------
>tr|E3BIA3|E3BIA3_9VIBR Sensory box/GGDEF family protein OS=Vibrio caribbeanicus ATCC BAA-2122 GN=VIBC2010_03035 PE=4 SV=1
------------------------------------------------------------------NRIRKSELLNRESQTLLELVFDQSYQFIGVLNHQ
GCVVSTNRKLNDLIYSQHVNP-ELP-LWEHPNWDDSFAQHLRHFLSRD-TDEIAYQFEAEFWHAEQGALVLEISLKNFYLLN-HHRQCLLEARDITSRKI
TEERLYQREHYYDKQPVMMVTLDDRDRIQQVNQFAEQLLGYRLDSILGHKLNQFYVQEDTLLPRQVLLQPGSMTGVWRREVEYRHSDGHILWIRENIKPL
IETGHLLI----VGEDITETKHLSEQLQYQAQHDVLTGTYGRNYFEKLLDEALKEVAACTRVHAMLYLDLDQLKILNDTAGHEAGDAAIVFCSDLLYQVL
PKSATLARMGGDEFAILLKDCSAPDAKKIANLIIDSLGTPFVWQGIQCHLRCSIGIRLIDHTADSPQMVHAQADTACQVAKDEGRGRFSLYCYGDRELRR
REEQMEALVNNAIANQRVELFAQRIQSLSTKDGLYFEILARLRNAQGEYLSPSIFMPATERYNIAHLLDKEVVNKAV----NWLEAHAALTLCSINLSGH
SIGNQQFIEFLVDKLTHTSIPCEKICFEVTETAAISNSDRAHQLFQRLRALGCSFALDDFGSGLSSFGYLKTLPVDIVKIDGIFVRDMDTNDVDQLMVRS
IHKLAKQMGKKTVAEFVENRQVMDILSEIGVDYAQGYAIGRPKPLVELETEC--------
>tr|I1DH39|I1DH39_9VIBR Sensory box/GGDEF family protein OS=Vibrio tubiashii NCIMB 1337 = ATCC 19106 GN=VT1337_09467 PE=4 SV=1
------------------------------------------------------------------SRIKRSEQLAKDSQTLIEMVFDQSYHFIGVLDDN
GHITSSNSKLQDLLYDQNFSV-DRP-IWQHRHWEQEASQQLKQFFTTE-H-DTLAQFEAEIWHSDQGSIVLELSLKPIPIPD-KGTQYLLEARDITSRKI
TEERLFQREHYYDQQPVMMLTLDEQNRIQQVNQFAEQLLGYAADEVLGHRLREFYFHEATLIPRQVLLQPLAIKGVWRREVEYRHANGHTVWVRENIRPL
AESGHLLI----VGEDVTETKALSEQLQYQAQHDLLTGTYSRNYFEAELEKALKEVESYTRTHAMLYIDLDQLKVLNDTAGHEAGDAAIQFCASMLEETL
PYNTILARMGGDEFAILLKDCTEVDAKKLATTIINTLSHAFIWEDIRLNLNCSIGIRLIDHTASSPQMVHAQADTACHIAKEEGRNRYSMYCLDDQELRR
REQEMENLVHNALANNRLELFAQQILDLTGEQGIHFEILVRIRNVDGEYISPGIFMPASERYNIAHLIDKQVVSQTL----DWFEQHPHLGLCSINLSGH
SMGNKEFTAYLLEKLKSSSVPCEKICLEITETAAMSNMNQAIEFFGQLKALGCCIALDDFGSGLSSFGYLKKLPVDIVKIDGIFVRDMDTNEMDHLMVRS
INDLARQMGKQTVAEFVENAQIIELLMELGVDYAQGYVIGKPKPLAELVSEL--------
>tr|A0A0A5I5E6|A0A0A5I5E6_9VIBR Diguanylate cyclase OS=Vibrio tubiashii GN=NM22_18295 PE=4 SV=1
------------------------------------------------------------------SRVKRSQQLTKESQTLIEAVFDQSYHYIGVLDEQ
GHIVSSNQKLQDLLYDQNYNV-ERP-IWQHRHWQTESSQQLERFFTSD-EKEVVFQFEAEIWNADRGSVVLALLLKPIPLPI-KGTQYLLEAQDITSRKI
TEERLYQREHYYDQQPVMMLTLDEQNRIQQVNQFAEQLLGYRSDQVLGHRLREFYFDENSLVPRQVLLQPQAIKGVWRREIEYRHADGRIVWVRENIRPL
AESGHLLI----VGEDVTETKVLSQKLQYQAQHDLLTGTHNRNYFESELDKALREVESYIRTHAMLYIDLDQLKVLNDTAGHEAGDAAIQFCASVLEEVL
PYNTVLARMGGDEFAILLRDCTELDAKKLASTIINTLSHAFVWEDIKLNLNCSIGIRLIDHTASSPQMVHAQADTACHVAKEEGRNRYSLYCLDDQELQR
REREMENLVHNALANQRIELFAQQIMDLSGRQGMHFEILVRIKNSKDEYISPGIFMPASERYNIAHLLDKQVVSQTL----TWFEQHLQLAVCSINLSGH
SMGNKEFIAYLLDRLEHSSVPCEKICFEITETAAMSNMNLAIEFFGKLKALGCCIALDDFGSGLSSFGYLRQLPVDIVKIDGIFVRDMDRNEMDHLMVRS
INDIAKQMGKQTVAEFVENAQIIELLLDLGVDYAQGYVIGRPMPLSELVTQL--------
>tr|E8LUF2|E8LUF2_9VIBR Sensory box/GGDEF family protein OS=Vibrio brasiliensis LMG 20546 GN=VIBR0546_10609 PE=4 SV=1
------------------------------------------------------------------SRIKRSEQLAKESQTLIEMVFDQSYHFIGVLDPQ
GCITSSNSKLQELLYHQDFSI-DRP-IWQHRHWEAEAAKQLQLFFQQQ-SDDSATQFEAEIWHAEHGSMVLEVALKPIPSLQ-GGKQYLLEARDVTSRKI
TEERLYQREHYYDQQPVMMVTLDEQNRVQQVNQFAEQLLGYKSDQLLGHRLKEFYLNSDALIARQVLLQPQAIKGVWRRDIEYRHANGNTVWVRENIRPL
VESGHILI----VGEDVTETRKLSEQLQYQAQHDLLTGTFSRNYFERELEKALREVASYTRTHAMLYIDLDQLKVLNDTAGHEAGDAAIQFCASMLEEVL
PYNSILARMGGDEFAILLKDCTELDVKKVAGTIITTLSHAFIWEDIRLNLNCSIGIRLIDHTASSPQMVHAQADTACHVAKEEGRNRYSMYCLDDKELRR
REQEMENLVHDALANQRIELFAQQILDLTGEQGMHFEILIRIKNAEGEYISPGIFMPASERYNIAHLLDKQVVTQAL----DYLSGNPELNTCSINLSGH
SMGNKEFIRFLLDKLSQSSVPCDKICLEITETAAMSNMNQAIEFFTQLKALGCQIALDDFGSGLSSFGYLKKLPVDVVKIDGIFVRDIDVNEMDHLMVRS
INDLARQMGKKTVAEFVENTHIIEQLMELGVDYAQGYIIGKPKPLAELIEEL--------
>tr|A0A0A6CGW1|A0A0A6CGW1_9VIBR Diguanylate cyclase OS=Vibrio variabilis GN=NL53_19555 PE=4 SV=1
------------------------------------------------------------------SRLKRSEQLATESQMLTEMVFDQSYHFIGVLDSK
GGVTSSNRKLQELLYSQDFSQ-DLP-IWQHRYWQEDAVALFKRFLDDK-QAETVTQFEAEIWHEELGALVLEVSLKPIPSGV-ESARYLLEAKDITTRKI
TEERLYQREHYYDQQPVMMVTLDDQNRIQQVNQFAEQLLGYTPDQILGHRLREFYLHEDALIPRQVLLQPQVMKGVWRREIEYRHADGQVLWIRENIRPL
VESGHLLI----VGEDITETRKLSDQLAYQARHDLLTGTFSRNFFEKELTKALKEVESYTRTHAMLYLDLDQLKVLNDTAGHEAGDEAIKFCARTLEEVL
PYNTVLARMGGDEFAILLKDCTELDAKKLAKMIIDNLGQPFVWQDIRLSLNCSIGIRLIDHTASSPQMVHAQADTACHVAKEEGRNRYSLYCLDDQELRR
REQEMENLVHDALANQRIELFAQRIIALDNDKGMHFEILVRIRDVNGGYISPGIFMPASERYNIAHLIDREVVSQTL----DWFSANPALSQVAINLSGH
SMGNQEFIQFLLNKLQESAVPCNKVCLEITETAAMSNMKQAIEFFSQLKALGCLIALDDFGSGLSSFGYLKKLPVDIVKIDGIFVRDIDVNEMDHLMVRS
INDLAKQMGKRTVAEFVENTRIIDQLMELGVDYAQGYIIGKPKPLPTLVEEL--------
>tr|A0A0A0STG1|A0A0A0STG1_9VIBR Diguanylate cyclase OS=Vibrio coralliilyticus GN=IX92_00235 PE=4 SV=1
------------------------------------------------------------------SRLKKSETLAKESQTLIEMVFDQSYHFIGLLDAQ
GRTVSSNSKLQELFYHQDFSV-DRP-IWQHQHWEDQAAQQLKSYFNTD-ESEQNTQFEAEIWHSEQGSIVLEISLKPLPKTG-QGADFLLEARDITSRKI
TEARLYQREHYYDQQPVMMITLDDHNCIQQVNHFAEQLLGYTSNQVLGHSLGEFYFHQDAVTPRQVLLQPQAMRGVWRREIEYRHADGRAVWVRENIRPL
IESGHLLI----VGEDITETKKLAEQLEYQARHDLLTGTFNRNHFEMELAKSLLEVESYTRTHAMLYLDLDQLKVLNDTAGHEAGDTAIQFCASMLEEVL
PYNAILARMGGDEFAVLLKDCTERDAKNVANTIVMTLSQPFVWDDIRLNMTCSIGIRLIDHTADSPQMVHAQADTACHAAKEEGRNRYNLYCQDDADLQR
REQEMESLVHNALANDRIELFAQQILALSQDAPMHFEILIRIRNAEGEYISPGIFMPASERYNIAQLLDKQVVTQTL----DWLAANPELGMCSINLSGH
SMGNKEFIAFLLDTLQHSPVPCEKICLEITETAAMSNMNQAIELFSQFKQLGCKIALDDFGSGLSSFGYLKKLPVDIVKIDGLFVRDIDVNEVDHLMVRS
INDLAKQMGKQTVAEFVENTRIIDLLVELGVDYAQGYVIGKPKPLEELVDEL--------
>tr|C9QC16|C9QC16_VIBOR Sensory box/GGDEF family protein OS=Vibrio orientalis CIP 102891 = ATCC 33934 GN=VIOR3934_08921 PE=4 SV=1
------------------------------------------------------------------SRIKRSEQLAKESQTLIEMVFDQSYHFIGVLDEQ
GTVVSSNRKLQELLYDHNFSV-ERP-IWQHHHWEVDTAQQIEQFFTDG-AHDIITQFEAEIWHAELGSMVLELSFKPIPSLN-SGKQFLLEARDITSRKI
TEERLFQREHYYDQQPIMMLTLDDQNRIQQVNQFAEQLLGYTSDQLLGHRLRDFYLHDDAIIPRQVLLQPQALKGVWRREIEYRHCDGHTVWIRENIRPL
VETGHLLI----VGEDVTATRQLSDQLQYQAEHDLLTGTYSRNYFETELVKALAEVESYTRTHAMLYIDLDQLKVLNDTAGHEAGDAAIQFCASMLEEVL
PYNTILARLGGDEFAILLRDCTEVDAKKLASTIINTLSHPFIWEDIRLNLNCSIGIRLIDHTALSPQMVHAQADTACHVAKEEGRNRYNLYCLDDKELRR
REQEMENLVHDALANQRIELFAQQILSLTDSSGMHFEILIRIKNAQGEYISPGIFMPASERYNIAHLLDKQVVTQTL----DWLAENDKLSLCSINLSGH
SMGNKEFIAFLLNKLETSTVPCEKICLEITETAAMSNMNQAIEFFTQLKELGCRIALDDFGSGLSSFGYLKKLPVDIVKIDGLFVRDIDVNEMDHLMVRS
INDLARQMGKKTVAEFVENTRIIEQLMELQVDYAQGYIIGKPKPLAELVEEL--------
>tr|E8MCH3|E8MCH3_9VIBR Sensory box/GGDEF family protein OS=Vibrio sinaloensis DSM 21326 GN=VISI1226_18746 PE=4 SV=1
------------------------------------------------------------------SRLKRSEQLATESQTLIEMVFDQSYHYIGVLDEK
GGITSSNSKLQELLYNQDFTH-EQP-IWRHQYWQNDAVEHFKRFFAEE-DYDAVAQFEAEIWHAELGALVLEVSLKPIPSGI-ASARYLLEARDITSRKI
TEERLYQREHYYDQQPVMMVTLDDQNRIQQVNHFAEQLLGYTPDQILGHRLREFYLHEDALIPRQVLLQPQVMKGVWRREIEYRHADGRVLWIRENIRPL
VESGHLLI----VGEDITETHKLSEQLAYQARHDMLTGAFSRNYFEKELDKALKEVESFTRTHAMLYLDLDQLKVLNDTAGHEAGDAAIQFCASMLEEVL
PYNTVLARMGGDEFAILLKDCTEFDAKKLAKMIIDTLSQPFIWEDIRLSLNCSIGIRLIDHTASSPQMVHAQADTACHVAKEEGRNRFSLYCLDDKELRR
REQEMENLVHNALANQRIELFAQRIISLEDDEGMHFEILVRIRNAKGEYISPGIFMPASERYNIAHLIDKQVVSQTL----DWFADHPELSQVAINLSGH
SMGNKEFTQFLLARLEESPVPCSKVCLEITETAAMSNMNQAIEFFSQLKSLGCVIALDDFGSGLSSFGYLKKLPVDIVKIDGIFVRDIDVNEMDHLMVRS
INDLAKQMGKRTVAEFVENTRIIDQLMELGVDYAQGYIIGKPMPLQQLVSDL--------
>tr|F9REM4|F9REM4_VIBSN Sensory box/GGDEF family protein OS=Vibrio sp. (strain N418) GN=VIBRN418_03831 PE=4 SV=1
------------------------------------------------------------------SRLKRSEQMALDNQTLIEMVFDQSYHYIGILDQN
GCIVSSNSKLQDLLYQQNSVS-EKP-IWLHHHWEQNAADRIERYFLTS-DESSNCQFEAEIWHPEQGSMVLELSLKPLPQHEHREAQILLEARDITSRKL
TEERLFEREHYYDQQPVMMITLDEQNRIQQVNRFAEQLLGYKENQILGHRLKSFYVDDDASIPRQVLLQPQVMKGVWRREVEYRHQNGHSLWIRENIRPL
VESGHLLI----VGEDVTTLRQMADQLAYQAQHDLLTDTYNRNHFEIELEKALKEVESYTRTHAMLYLDMDQLKVLNDTAGHEAGDAAIQFCASLLEEVL
PYKAILARMGGDEFAVLLKDCTERDAKNVASSIIAMLAQAFIWDDIKLNLSCSIGIRLIDHTATSPQMVHAQADTACHAAKEEGRNRFSLYCQDDQDLRR
REMEMANMVHNALNNDRLELFAQRILGLEQDHRMHFEILVRIRNADGEYISPGIFMPASERYNIAHLIDKQVVRQTL----QWLAQHPNLALCAINLSGH
SMGNQEFIDFLLNELQESAVPCNKICLEITETAAMSNMNQAIEFFAQLKQLGCLIALDDFGSGLSSFGYLKKLPVDIVKIDGLFVRDIDNNEMDHLMVRS
INDLAKQMGKRTVAEFVENNQIIDLLIELGVDYAQGYAIGKPKPLAELVEEL--------
>tr|U3A7N7|U3A7N7_VIBPR Uncharacterized protein OS=Vibrio proteolyticus NBRC 13287 GN=VPR01S_27_00370 PE=4 SV=1
------------------------------------------------------------------RRLKKSEQIARHSQVLLESVFDQSYHYIGMLDQH
GRIVSSNSKLQELLYNPQYQL-DKP-LWQHKHLEAGSAQRIKHYFAAQ-QASRPAQFEVEVWHPEHGVQILELSLKPLPKDVGQQVRFLLEARDITSRKQ
TEDKLMQREHYYDQQPVMMLTLNEQNRIQQVNRFTEQMLGYEEQQLLGHRLREFYLHADAIVPRQVLLQPQVAKGVWQREIEYLHADGHAMWVRENIRPL
AETGHLLI----VGEDVTETRKLADQLAYQARYDLLTDTYNRNQFELELDKALSEVESHLRTHAMLYLDLDQLKVLNDTAGHEAGDAAIKFCASMLQEIL
PYNTILARMGGDEFALLLKDCTERDAVHVARSIISTLAQAFIWNDIRLNLTCSIGIRLIDHTATSPQMVHAQADTACHAAKEEGRNRFNLYCQDDQDLRR
RELEMESLVHDALANQRIELFGQRILNVSQPDSLYCEVLVRIRNSDGEYISPAIFMPASERYNIAHLIDKVVVSQSL----AYFASHPDLDLVSINLSGH
SMGNREFVQFLLQALASSPVPCGKICLEITETAAMSNMEQAISLFSQLKQLGCLIALDDFGSGLSSFGYLKRLPVDIVKIDGLFVRDIDHNEMDRLMVRS
INDLAQQMGKRTVAEFVENRAIYEHLVALGVDYAQGYLIGRPKPLAELMSEL--------
>tr|A0A087IEG6|A0A087IEG6_VIBVL Diguanylate cyclase OS=Vibrio vulnificus GN=JS86_23435 PE=4 SV=1
------------------------------------------------------------------RRIQQSETLARESQSMLESIFDQSLQYIGILDRN
GCLVSSNAQLQDLLFFQGVPL-DRP-LWQHQHWEDASASRLADYFSAT-E-AQLSTFEAEIWSRNLGAMMLEVSLKPLHSVGEQRGEYLFEARDITSRKL
MEEKLYKRENYYEQQPVMMVTLDKNNRIQQVNRFAQQLLGYQPLEMLGHLLQEFYCDTQAMTPRQMLLQPPALQGVWRREIEYRHQDGSAVWIRENIRPL
TESGQILI----VGEDISHNKQLARQLEYQAKYDLLTDTFNRNQFDIELKRALREVESHRRVHAMLYIDLDQLKVLNDTAGHDAGDGAIQFCASMLEEVL
PHTAILARLGGDEFAVLLKDSNEHTAIGVAKTIIATLSQPFIWEKVQINLTCSIGIRMIDHTAESPQMVHAQADTACHAAKEQGRNRFKLFSLDSEELQR
RQQEMENLVHDALANDRLELFAQRIIPLSKEDKMHFEILTRIRDKQGEYLSPAIFMPASERYNIAHLIDEQVVTKTL----DWLEARPDLGRCSINLSGH
SMGNPEFMAFLLDRLANSVIPCHKICLEITETAAMKNISLAMDFFAQVKALGCLIALDDFGSGLSSFGYLKQLPVDVVKIDGIFVQDMHRNESDHIMVRA
INELAQQMGKQTVAEFVENSEIVALLTELGVDYAQGYVIGYPTPLAELVAQW--------
>tr|A7K0T8|A7K0T8_VIBSE FOG: EAL domain containing protein OS=Vibrio sp. (strain Ex25) GN=VEA_001950 PE=4 SV=1
------------------------------------------------------------------QRIRRSESAARESQAILESIFDQSMQYMGILDAN
GVLKSGNDHLQSLLYHQGLRL-DRP-LWFHPNWSEKAQSLLEAYFHAP-H-HQVSTFEAEIWSKEHGTLVLEISLKPFSQQVGNQNQYLFEARDITSRKL
MEDKLYQRENYYEQQPVMMVTLDSNNRIQEVNRFAQLLLGYKPMDMLGHRLREFYFDDKVLFPRQVLLQPQQVHGVWRREVEYRHANGHRVWVRENIRPL
SESDQLLI----VGEDITETKQLSEKLEYQARYDLLTGTYNRNHFELELKTALREVDSHRRVHAMLYLDLDQLKVLNDTVGHDAGDAAIQFCASMLEEVL
PYNSILARMGGDEFAVLLKDCDEYGAINIAKLIISTLSHLFIWEDTRLFISCSIGIRIIDHTAETPQMVHAQADSACHAAKEQGRNRYNLFSLDNEELQR
RQMEMQNLVHEALSNQRLELFAQPIKSLQQHAQMYFEILVRIRNGYGDYVSPALFIPASERYNIAHWIDKQVITQTL----EWFEQRPELGRCSINLSGQ
SMGNQEFIDFLLERLERSSMPCEKICLEITETAAMSNLEQAIELFTKLKALGCMIALDDFGSGLSSFGYLKKLPVDIVKIDGLFVRDINVNEMDRVMVRS
INDLAKQLGKVTVAEFVENEQVMQHLIDLGVDYGQGYGIGHPQPLSELVERL--------
>tr|A0A099MRM9|A0A099MRM9_9VIBR Diguanylate cyclase OS=Vibrio navarrensis GN=DC58_13690 PE=4 SV=1
------------------------------------------------------------------RRLRRSESLARESQLILESIFDQSLQYIGILDQH
GCLISSNSQLQTLLFYPGMPL-ERP-LWQHKHWEDESGARLASYFASS-E-SMVSTFEAEIWSAEQGSIVLEVSLKPFSSQAKKAPRYLFEARDITSRKV
MEDKLYKRENYYEQQPVMMVTLDANNRIQQVNRFAQQLLGYPQMSMLGHHLHDFYCDSKAMNPRQVLLQPPDMKGVWRREIEYRHTNGEAVWVRENIRPL
TESGQVLI----VGEDISHNKQLATQLEYQAKYDLLTDTYNRNQFEIELKRSLGEVESHRRVHAMLYIDMDQLKVLNDTAGHDAGDAAIQYCASMLEEVL
PHNAVLARLGGDEFAVLLKDSNEHTAIGVAKSILATLGEPFVWETVRLNLTCSIGIRMIDHTADSPQMVHAQADTACHAAKELGRNRYQLFSLDSEELQR
RQQEMENLMHDALANDRLELFAQRILPLSREKKMHFEILVRIRDSDNRYLSPAIFMPASERYNIAHLIDEQVVNQTL----DWLEARPELGRCSINLSGH
SMGNPEFIQFLLDRLAHSVIPCERLCLEITETAAMKNVALAMEFFAQLKALGCLIALDDFGSGLSSFGYLRQLPLDIVKIDGMFVRDMHENETDLIMVRA
INELAQQMKKQTVAEFVENPDIIDRLLELGVDYAQGYVIGKPKPLGELIEEL--------
>tr|A0A0D0HRS8|A0A0D0HRS8_VIBHA Strain BSW5 contig_8, whole genome shotgun sequence OS=Vibrio harveyi GN=SN10_06605 PE=4 SV=1
------------------------------------------------------------------QRIRRSESIARESQAILESVFDQSMQYMGILDHH
GLLNSGNDRLQSLLYHQDIRL-DRP-LWHHKHWSEEARQLLANYFQSQ-N-RNVATFEAEIWSTEHGAMVLEVSLKPFSQQVGDQEQYLFEARDITSRKA
MEDKLYQRESYYEQQPVMMVTLDNNNRIQEVNRFAQQLLGYQPLDMLGHHLCAFYSDEKALYPRQVLLQPQVMHGVWRREIEYRHADGHSVWVRENIRPL
RDSDQLLI----VGEDITETKKLAKQLEYQASYDLLTDTYNRNYFELELQTALREVESHRRVHAMLYLDLDQLKVLNDTVGHDAGDAAIQFCASMLEEVL
PHNAVLARMGGDEFAVLLKDCDEYGAISVAKHIISTLSQLFRWEDTRLFMSCSVGIRIIDHTAETPQMVHAQADSACHVAKEQGRNRYNLFSLDNEELQR
RQLEMQNLVHEALSNKRLELFAQQILNLRGESPLCFEILVRIRDAQGNYLSPGIFMPASERYNIAHWIDKQVITQTL----EWFEARPELGRCAINLSGQ
SMGNQEFIDFLLERLQLSSIPCEKICLEITETAAMSNIDQALGFFTRVKALGCLIALDDFGSGLSSFGYLKQLPVDIVKIDGLFVRDINTNEMDRVMVRS
INDLAKQLGKVTVAEFVENDQITEHLKALGVDYGQGYAIGHPQPLAELVEAL--------
>tr|F9SI24|F9SI24_VIBSP Sensory box/GGDEF family protein OS=Vibrio splendidus ATCC 33789 GN=VISP3789_02532 PE=4 SV=1
------------------------------------------------------------------NRLKKSERASRQSQRLLESIFDQSLQFMGIIDKG
GVLLSSNSKLHELLYNQGYKL-GTP-LQEHQHWEDSASEVLKEYFVER-DDHPSLRFEAEVWCRDRGAMVLDISLKPMPGSEEGDIQFLFEARDVTSRKL
AENKLFQRELYYDKQPVMMITLDGNNRIQQVNQFAEELLGYPLDELLGHRPGEFYVDENAMIPRHILLQPHKIRGVWRRDIEYRHADGSTIWIRENIRPL
VESDQLLI----VGEDITETHELSEKLEYQARYDLLTDTFNRNHFEQELQKALKEVESHMRTHAMLFLDLDQLKVLNDTAGHEAGDAAILFSAQLLEEVL
PYNAVLARMGGDEFAVLIKDCTERDAVNVCRSIISMMGNPFLWDDIRLNLTCSIGIRLIDHTAATPQMVHAQADAACHAAKEEGRNRYHLYHQDDEDLRR
RHLEMENLVHEALANDRLELFAQRILGLDEDDKMHFEILVRIKNVDGEYISPGIFMPASERYNIAHLIDRQVIGQTL----SWLEQRPHLGMCSINLSGH
SMGNREFVEFLIESLSNSSIPCHKICLEITETAAMSNMKQAIKFFTRIKDLGCMIALDDFGSGLSSFGYLKKLPVDIVKIDGLFVRDIDVNEMDHVMVRS
INDLAKQMGKHTVAEFVENTQIIDKLIELGVNYAQGYIIGRPKPLAELVDEL--------
>tr|A0A066UN69|A0A066UN69_9VIBR Diguanylate cyclase OS=Vibrio fortis GN=VFDL14_14955 PE=4 SV=1
------------------------------------------------------------------NRLKKSERDSRKSQILLESIFDQSLQFMGIIDRD
GVLLSSNSKLHELFYNQGYQV-GTP-IYQHQHWEDAASDSLKKYFMEA-QSYTSLRFEAEVWCRDRGVLVLDISLKPMPDSESSELQFLFEARDVTSRKL
AENKLFQRELYYDKQPVMMITLDENNRIQQVNQFAEELLGYPLSELLGHRPREFYVDRNAMIPRQILLQPHKSRGVWRRDIQYSHADGSKIWIRENIRPL
VDSNQLLI----VGEDITETHELAEQLEYQARYDLLTHTFNRNHFEQELQKALKEVESHMRTHAMLFLDLDQLKVLNDTAGHEAGDAAILFSAGLLENVL
PYNAVLARMGGDEFAVLLKDCTERDAVNVCRSIIAMMGNAFLWDDIQLNLTCSIGIRLIDHTAASPQMVHAQADAACHAAKEEGRNRYNLYHQDDEDLRR
RHLEMENLVHEALAHDRIELFAQRILGLDKQELMHFEILVRIKNHNGEYISPGIFMPASERYNIAHLIDRQVVSQTL----AWLEENHGLGMCSINLSGH
SMGNREFVEFLIDSLEQSAVPCDKICLEITETAAMSNMNQAIELFTQLKELGCMIALDDFGSGLSSFGYLKKLPVDIVKIDGLFVRDIDVNEMDHVMVRS
INDLAKQMGKYTVAEFVENTQIIDKLIELGVNYAQGYIIGRPKPLPELVEEL--------
>tr|U4E299|U4E299_9VIBR Putative TWO COMPONENT HISTIDINE KINASE OS=Vibrio nigripulchritudo FTn2 GN=VIBNIFTn2_1640006 PE=4 SV=1
------------------------------------------------------------------KRLKRSEIQAKQSQLLLESVFDQSYQFIGIVDRF
GTLVSSNSKLQDLLYVKGGAY-GRP-LWQYRGWSDEAKATFKSYLEKP-GQDGVARFEAELVRQHHGLSVLDVAMKPLPHEIGEACHFLLEAQDITARKA
TEHKLLTSEHYYEKQPVMMMTLDENNRIQAVNRFAQELLSYSSTQMLGRKLEDFYAGSEELNARQVLLQPPHHLSVWRREIEYTTANGFTIWVRENIRPL
TETHQLLI----VGEDISETQDLARQLAYQAQHDLLTGTYNRNFFEQQLQKAMVEVEGHFRTHAMLFLDLDQLKVINDTVGHEAGDEAIAFCAKLIQQVL
PNNAILSRMGGDEFALLLRDCKKTDATEVAQSIIDQLNNPFIRDDLTLNISCSIGIRLIDHTAHSPQMVHAQADTACHAAKEEGRNRYQLYRLDDEEIKQ
REREMENLVHEALANQRLQLFAQRIKGLEDEHQCYFEILVRLQDANGNYVSPGVFMPATERYNIAHLVDRYVIKQTL----LWLDQHPELDRVSINVSGQ
SIGNREFIASMKQALQDSQFPNEKICLEITETAAIHSIKQASQVFDELKSLGCLIALDDFGSGLSSFGYLKTLPVDIVKIDGIFVRDIDQNESDYIMVRS
INDLAQQMGKVTVAEFVESPAVIERLCELGVNYGQGYNIGMPKPLGELVNDL--------
>tr|Q6LLM3|Q6LLM3_PHOPR VV11110 protein OS=Photobacterium profundum GN=VV11110 PE=4 SV=1
------------------------------------------------------------------RQLRKSEQELQQSQALFEGVFDQSFQYIGILDSS
GVLISGNFALQNLLGHKIIKY-DRP-LWRWHCWQQEIAVKLNQAFISA-QQGQLLRFEAAVQSVDDGIRVLDISIKNMPTAQGNSDQVLIEARDVTSRHQ
MEDKLRERELLYEQQPVILLAIDSQARIQSVNQFAADLLGYKKRDMLGHKVTDFYLDN-AVLPQQFISSSNDDQIVWRRQLRYKCAEGKVVWVRETIRST
QSKLQLLL----VGEDITSTRELEEKLEYQACHDYLTGLFNRNYFETQLENVLVEAREHETRHAMFYIDLDQFKVINDTAGHEAGDEALKQVALLLQEIT
PEHATLSRLGGDEFAIILRHCTQHEAVTFGDEILHLLEAEFFWQSTRFSFSCSLGIRLIDETAGSPQQVHAQADTACYAAKDEGRNRLHLYHPDDEELKR
RELEMENHIHKALAEQRFELHAQQIAPVASG-KQHYEILVRMRNSDGSMVSPGLFMPAAERYNIAHLIDRYVVKGVI----EWLQANKELELCSINLSGQ
SMGNRDFVGFLIEQIRDSGLPPSKLCLEITETAAIGNMSEAIQLFTQLKNLGCLIALDDFGSGLSSFGYLKRMPVDIIKIDGMFVRDIAEDEMDFAMVKA
INELAKKMGKRTVAEFVENEAILMRLQSLGVDYAQGYLFGKPKPLAELVAEL--------
>tr|L8J795|L8J795_9GAMM Diguanylate cyclase OS=Photobacterium sp. AK15 GN=C942_03916 PE=4 SV=1
------------------------------------------------------------------RRLHKGEQKLQRSRALFEGVFDQSFQYIGLLDDN
GVLISGNLALQNLVGRSVIKY-DRP-LWRWLCWNQGATLSLSQAFESA-WQQQRVRFEVEVQSIDDGWRVLDIAMKRMPSTEGEKEQLLFEARDVTSRHQ
MEEKLREREVLYEQQPVILLALDNKARIQSVNQFAADLLGYDKRELLGHKVTEFYYDD-VPVPQQYISGVPDEQQVWRRKVRYRCADGKTVWIRETIRSA
QLKQQLLL----VGEDVTATYELEAKLAYQANHDFLTDLYNRNHFEKQLETALQEAREQDARHAMLYIDLDQFKVINDTAGHEAGDEALKQVALLLRGIT
PSQATLARLGGDEFAIILHNCSQAEAVKFGTEVLLVLEAEFYWQNTRFNFSGSIGIRLIDHTAGSPQQVHAQVDTACYAAKDEGRNRLHLYHPDDEELKR
RELEMENLIREALADRRLELFAQQVTPLSVV-KQHYEILVRIRDRDGSIVSPGLFMPAAERYNLAHLIDRYVINEVI----DWLVAHPQLGLCAINLSGQ
SMGNRDFVYFLIDKIRSSGLPTHKLCLEITETAAIGNLSEAIMLFTQLKELGCLLSLDDFGTGLSSFGYLKRMPVDFIKIDGIFVRDIAKDEMDFAMVKA
INELAKKMGKKTVAEFVENDAILQRLNVLGVDYAQGYLFGRPKPLAELVAEL--------
>tr|D0Z0V2|D0Z0V2_LISDA Sensory box/GGDEF family protein OS=Photobacterium damselae subsp. damselae CIP 102761 GN=VDA_003166 PE=4 SV=1
------------------------------------------------------------------RHLRRSEQQLQRSQALFETVFDQSFQYIGILDLH
GHLVSANLALQEMLGDDGVKF-DRP-IWRWLCWNSDTASQLNQAFLAA-DTEFLLRFEAKAQSQNDGIRILDISLKAMPYQAATEPQILFEARDMTSRRQ
MEQKLRERELLYEQQPVILLTIDNSARIQSVNQFAADLLGYHKRDLLGHKITEFYLEG-ILPPHQIISHS-ESREVWRRQVQYRRADGETVWVRETVRQA
QAKHQLLI----VGEDITSTRELEQRLAYQANHDYLTGLYNRSYFESQLELALDEVQQQDVQHAMLYIDLDQFKVINDTAGHEAGDEALKQVALGLQNLA
TENTILARLGGDEFAVILRHCDEEQALALGRKILHLLDAEFLWQNTRFNFSCSLGIRLIDKTAGSPQQVHAQADTACYVAKDEGRNRLHLYRPDDEELKR
REHEMHNRIRRALVECRFELYAQQIAPIGRS-NHHYEILLRMRELDGSIASPGVFIPAAERYNLAHLLDRYVIQQVL----SWYQQHPELGHCSINLSGQ
SIGNQEFVKFLLHQIRHSTVPANKICLEITETAAIGNMTQAISLFTQLKELGCLISLDDFGSGLSSFGYLKRMPVDVLKIDGMFVRDIDKDDMDFAMVKA
INELAKKMGKQTVAEFVENKAILDKLESLGVDYAQGYYFGQPKPLAELVDDL--------
>tr|A0A0C5WPJ1|A0A0C5WPJ1_9GAMM Hipothetical sensory box/GGDEF family protein OS=Photobacterium gaetbulicola Gung47 GN=H744_2c0236 PE=4 SV=1
------------------------------------------------------------------RRLRKGEQRLQQSRALFEGVFDQSFQFIGIFDRS
GMLVSGNLALHELVGRAVVKY-DRP-LWRWFCWSPEAALKLSRAVTQA-R-SQPVRMEIDIQSHEDGSRMLDIVIKRMPADESGEVQLLLEARDVTARHQ
MEEKLRERELLYEQQPVMLLTVDRQSRIQSVNQFAADLLGYSKRDLLGHKIASFYDGD-EPVPQCYISSASAGHRVWRRQLRYCCADGRTVWIRETIRQA
QNR-QLLV----VGEDISSTRELEEQLAYQACHDYLTDLYNRNHFEQSLEKALAEARERQAQHAMLYIDLDQFKIINDTAGHEAGDEALKQVALMLQEIT
PARAVLARLGGDEFAVILTDCQLAEAVAFGREILQLLESEFYWQTARFSFSASIGLRMIDETAGSTQQVHAQADTACYAAKDEGRNRLHVYHPDDEELRR
RELEMESLLRRALSEQRLELYAQPIAPLCSS-GHHYEILVRIRNDDGEMISPGLFMPAAERYNLAHRIDRYVACAVI----DWLEANPGLDMCAVNLSGQ
SIGDRDFVHFLQDKIRHSSIPAHKLCLEITETAAIGNMSEAIRSFTLLKELGCRISLDDFGSGLSSFGYLKRMPVDIIKIDGMFVRDIADDEVDFAMVKA
INELAKKMGKQTVAEFVENEAILAKLGELGVDYAQGYLFGRPQPLPQLVAEL--------
>tr|R1GNC1|R1GNC1_9GAMM Diguanylate cyclase/phosphodiesterase OS=Grimontia indica GN=D515_03588 PE=4 SV=1
------------------------------------------------------------------NRQKQGERALAQSRALFKGVFDQSHQYIALLDYQ
GRVISANGAFQRLFPEFGNRG-FLP-LWRWSEWLSADRLKLH--LESL-IEGQASRFEVCLLSEQQNEVILDVALKALPDHSHADAQILFEARDISQRKL
AEQKLQRSEMLYEQQPVMLLTIDQQSRIQSVNQCTTEWLGFSKRHMLGHKVTDFYADG-SLPPRSLLNGKRERFGIRRREIRYRTSDGKERWIRESIRST
QVQSQLLL----VGEDITENRRMEQQLRYQAQHDFLTGLLNRNYFEARLVDVLGTLTENGATHAMFYIDLDQFRVINDTVGHEAGDEALKQTAQVLRELL
PIGATLARLGGDEFAVICYDCNEQDALDQGRKILDTLSLDFYWKNTRLALGCSVGIRMLDKTAGTPQQVHAQADTACYAAKHDGRSRVHLYRPDDQELRR
HEREMSSKIHAALAEDRFEVYAQPIVSVTSREKLYFEVLVRMRDTKGENVAPGQFIPAAERYNMAHLIDKRVIEKTL----GWFERYPEVGMVSINLSGR
SMSDEGFIQFLIEALKTSTIPSTSISLEITETAAIGNLSDAIELFKKLKQLGCTIALDDFGSGLSSFGYLKRLPVDIIKIDGQFVRDIAEDETDYVMVRA
IHQLATQMGKKTVAEFVENDAILMRLRSLGVDYAQGYYFSVPKPMEQLILEA--------
>tr|R9PG61|R9PG61_AGAAL Phosphodiesterase OS=Agarivorans albus MKT 106 GN=AALB_0435 PE=4 SV=1
------------------------------------------------------------------RALTRTQRELAEHEQNLQSVFTFTEQASALLDEN
GHVQLLNQALMELLGERAYIV-GNS-LLDSHVWQHQLKQQLRDAIAKS-LAGEKVRFQAELNLEN-RNVLYDFALTPQSATNGIVEQVLLELRDLELIQL
EHRQLKQSELLFEQSPALLMLVNRLGVIVCCNQVAAKHLGMSKKQLELSQLRSLYAEQSQQVSL---LEYGIGSNKVTRQIAYNNGDNKQLWFKESFVRM
AEEDLFML----VCEDITATRSLAEELDFHANFDLLTGIYNRGFFERRLELLLNSSLSGEQQHALLFIDLAQFKVINDTFGHGSGDQALKQVAGVLEQMI
PESAVVARLGSDEFAILLEDSSQQGSLDFANLVIDRLNTHYVRDERMFSFGCSIGVTLFQQQQGSSQEVLAQADNACFTAKSLGRSRVYLYQMDDQMLLE
RQGQMETRIQKALREERFLLYAQAIVPVKPSDYLHYEVLLRMIDEEGRVVPPGAFLPAAENYNLADQIDRVVIQKTL----QWLSENPGLNMCSMNLSGQ
SLGSAEFVAWLLQTLEDSALPMNKLCFETTETVAIANLDVATEFFNKVRKLGCKIALDDFGSGLSSFGYLKNLPIDYLKIDGIFIRDLENDHMDAAIVKS
INQMSHVMGKKTIAEFVENEAINKVLADIGVDFAQGYHFGKPVPIEMLVLN---------
>tr|A0A066RSN7|A0A066RSN7_9GAMM Diguanylate phosphodiesterase OS=Photobacterium halotolerans GN=EA58_07755 PE=4 SV=1
------------------------------------------------------------------RRLRRSERKLNQSRTLFEGVFDQSFQFIAILTQR
GQLKSANLALQDLLGRSVIKY-DCP-FWEWGCWDRASTEQLKQSFLSA-SHSQLVRFETGINSSEDGVRILDISMKPLPQTEKEEGQLLLEARDVTARHH
MEEKLRERELLYEQQPVILLAINQHGRIQSVNQFATELLGYSKREMLGHKVTDFYLDD-AEIPQHFISTHKEEQSVWRRQLRYTCASGKAVWIRETIRSS
LSQHQLLL----VGEDITSTRELEAKLEYQANHDYLTSLFNRSYFERLLESSLVEAREKSARHAMLYIDLDQFKVINDTAGHEAGDEALKQVAWLLRGIM
PHKASLARLGGDEFAIILSHCEVEGALRLGAEILQLLESEFYWQNTRFSLSASIGIRLIDNTAGSPQQVHAQADTACYAAKDEGRNRLHLYRPDDEELQR
REREMANHIRHALDERRFELYAQTIAPLAHP-GHHYEILLRMRSSDGAMIPPGLFMPAAERYNLAHLIDRYVVGAAL----DWLEAHPELQLCSINLSGQ
SMGNPDFVDFLLARIGHSSVPPSKLCLEITETAAIGNMSEAIELFTQLKSLGCLISLDDFGAGLSSFGYLKRLPVDLIKIDGMFVRDIADDEVDLAMVTA
INDLAKKMGKQTVAEFVENEAILARLEQLGVDYGQGYLFGKPMPLSQLVQRL--------
>tr|A0YYE0|A0YYE0_LYNSP Uncharacterized protein OS=Lyngbya sp. (strain PCC 8106) GN=L8106_15704 PE=4 SV=1
--------------------------------------------------------------------------KVRQTRNFLQTLIDHLPVAVFVKEGF
GQFTFWNKTSERLFGLKSEQVIGKT---VHELFPPEQAKRIQQDQE-ALNWGDISE--ESVNSLNSGRRILHTVKVPLYDDEMEPEHLLCICEDITERQQ
AEAQLRENESIYQGAAVSIFVVDVDFRYVGLNPIHEQLTQFTTAQLKGKTPQILPAS--YAKVVRQHIDCVTAKKTIS--YEEVMPFQESISHWLTLTPI
CDRNNHIYRIVGTSINITERKLAEEKLRYNAYHDSLTSLPNRPFFMERLQEAIQQVKTQKCLFSVLFFDLDDFKYINDSLGHAIGDQLLIALTDRLRSCL
RKTDILARFGGDEFTILLGGIQQDQVIKVAQNIQQELNLPFVLGSHQVFTNASIGIALVTADYQQPEEILRDADIAMYSAKAQGQGKSAIFNRQMHLKML
ERLQLETDLRQAIEQKQFQVYYQPIVCLKTDNITGFEALIRWKHPNGNFVSPAKFIPITEITGLIVEIGQWVLHQACLQMKTWHEQFPNNLTISVNLSGR
QLREPDVVDKIDDILQETGLKRDCLKLEITESMLMDNPSAVKSLLKQIKSRQIKLSLDDFGTGYSSLSYLHSFPIDTLKIDRAFVVHANSEFKNKAITQA
IVTLAQNLGMEVIAEGIETTDQLEQLKQLKCEFGQGYLFSKPLTQADAETLLQST-----
>tr|C3XAF8|C3XAF8_OXAFO Diguanylate cyclase (GGDEF) domain protein OS=Oxalobacter formigenes OXCC13 GN=OFBG_01212 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------VPIHNENGQVTGLYCTFKTLPESSR
DTGTPFADENFLDEIRVGVMQLAQDTRILYANRTIKKLLGYTDETFPVSFNDLLHPQNRKVKSWQELWY---TTSHFHIELPLRCQDGSYILTNNEISLK
LDDKRKPAY-ALIATL-PSDKDYSGERRNLFLYDRLTSLPSRNYADLLLNDAIDRSAKSRQSFAILLLNLNRFKMVNESLGHEVGDELLKSIAIRLSTSL
RKEDIVIRMGNDEFIVVLQNIRNDNIDMIAHNLLYSISRPMKLAGHDLTVTASIGCSVYPRDSTEIDSLLKYADIAMIEAKRTGMNAFRFFNRDMSVTVL
DQLLNETSLMRAMEKKEFLAYYQPRLSLSTGKIVGLEALIRWNHPQKGLIPAAEFILQAERIGLIRRIGEFMLKTVTTQLMRWREKNKQLIPVAINVAST
ELYDSDLKNALKDILDKTGLSPKLFELEITETGLIEDIRKVRATLSEIRKMGITVSIDDFGTGYSSLSYLSTLPVDYLKIDSSFIANVIVNKNTASIVET
TINLAHSLHMQVIAEGVSTQEQLEFLVNRGCDQIQGYLCSRPLSPDELDIFLDKF-----
>tr|C3X4A6|C3X4A6_OXAFO Diguanylate cyclase (GGDEF) domain-containing protein OS=Oxalobacter formigenes HOxBLS GN=OFAG_01195 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------IPVKNAQNAVSGLYCSFRQDQKENS
PPARTSLNDAILDTVPVGVMQVSPDKRILYANRSICEMLGYTPGFFPERFNDLLHPTVQSANSWQDLWH---NTSHFFIELALKGKNGIYILTENDISLK
LDSGNKPAY-ALIVTQ-KSGKEITSFGPHLSLFDPLTSLPNRNYSDTLINNAMRRADRSGKNVAILLLDVNRFKMVNESLGHEFGDELLKLIANRLKTTL
RKADSVIRMGNDEFVIVLENVRKEDVNLVVRNIFNALSQPIHLGHHDITISVSIGCSLYPQDSSDIDTLLKYADIAKTDAKRSGSNMLRFFNRNMNITVL
DQLLAESNLLRAMEKNEFLMYYQPRLCLKTGQIAGLEALIRWDHPKKGILPASEFIVLAEKIGLIHRIGEFALDNVTRQLIAWQKQD-RPIPVAINVSSS
ELYGAKLKKALSGILRETGLASRLFELEITESKLIEDLDRVRHTLKEIRDMGIAISIDDFGTGYSSLSYLSALPVDYLKIDSSFIADVTQNHNVASIVET
TIRLAHSLNMQVIAEGVETPEQLQFLVAHECDQIQGYLCSRPLPAPELEKFMERF-----
>tr|F2K2B0|F2K2B0_MARM1 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1) GN=Marme_3071 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-------------------------------------------------KTGEFKAGELNHSTPDGSRIIFDLHGIPELNKDEEVESVILIGRDVTEKKR
SAEQMRQSESLVENSPDLIARFDDHCRLLYANPVLERLSGTPFIHFLGLSFTIYTKLEEESPIDESMRQVLKTGTSVEIEREIPSTSG-PMNCIVSLTPE
FNDRDELVSVLAVCKDMSEVKRYQEQVRYLSYHDSLTGLPNRATFLNDVRRLISNSKASAMKLGLLVFGLDHFKGVNDSLGYEYGDLILKSISNRLRDIL
PKNAIIARLGGDEFAAMLPTIPDEEFVCMATNISGELSLPVLIGRKEMPISISTGACLYPDDAFELDSLVRYADSALYAAKHEQRGSVRFYTPELTKQAQ
ERLQMRNDLRRALKNKEFIPYYQPKFDLQTREVLGAEALVRWNHPEKGLVPPFDFIPVLEEMGLVEEVDMMMLDMVCGQLEKWQQLTDTGGKIAVNFSGL
QFKYEKLLDKVVDIIESHKLTPKAIQIEVTEGVLLEHHDQLPLIFRDFKALGFSIALDDFGTGYSSLGYLSKYPIDTLKIDRSFVNNINKNEADDILIKT
IVSMAQNLKMDVVAEGVETKPQADWLASIGVRIVQGYLFGRPMSATNFEAAF--------
>tr|G4SZ12|G4SZ12_META2 Putative Diguanylate cyclase OS=Methylomicrobium alcaliphilum (strain DSM 19304 / NCIMB 14124 / VKM B-2133 / 20Z) GN=MEALZ_3813
----------------------------------------------------------------------------------------------------
--------------------------------------------------------YNIEHRLIDGKVKWLRERAELEFDRQRKMIGAVGTVQDITELKQ
AELALQQSFALLSAMSIGILFEDKAGSIEYVNLAFRRMWAIEDDDPVGQSTQVLENSTHRFHASKYVLKVLDTHEI-SERFELDLYDGRILTQV--SYPV
TDTEGRILGRLWIYEDITHERQTAQQLLYLAEHDALTGLYNRHRFQEQLDHMIAMARRNHDKFALIYFDLDEFKYINDNFGHRAGDTVLVRIAGEISVVL
REVEIFARLGGDEFAILSYLHPQNDISVLPNRINQAVAIPFRFRGTNIRLTTSVGLAFFPEHGETVEDLVAHADTAMYQAKANGKNTWAVYDPKRDGAAM
ERMSWRQRIEQALRQDLLELHFQGIYRVDNGQLCHFEVLVRMRDPQHPLVMPGQFIPIAENSGQILEIDRWVLRSSIALLSE----NSILPSLAVNISGR
SFDDPELPQFIRACLEENRVDANRLIIELTETAAVSDIRDAQRFIEGIRQAGCTVCLDDFGSGFSTFAYLKYLEVDILKIDGMFIRDLPNNRENQIFVKA
MVGIAKGMHKTVLAEFVEDAATLQMLKELGIDLAQGYHLGRPSA----------------
>tr|B8GU61|B8GU61_THISH Signal transduction protein containing a membrane domain an EAL and a GGDEF domain OS=Thioalkalivibrio sulfidiphilus (strain HL
----------------------------------------------------------------------------------------------------
--------------------------------------------------------FETLHRTRDGRDLQLE--VSLQYVLPDERPRYVAITRDISQRKE
QEKSLLKALALLSGMSIGILFEDTNGRVEYVNPAFRRMWAIGEPDLIGRPSRVLKHSTHRLHASRHILHVLDTHEI-SERFEVDLYDGRVLTQL--SYPV
ADPDGPVLGRLWIYEDITRERQTAQQLIYMAQHDALTGLYNRHRFQEHLDRMISSAQRNDSRFALLYFDLDEFKYINDTFGHRAGDTVLVRAAGEVSSLV
RSGEVFARLGGDEFAVLAEIRHDDEPSQLAERIARAISIPFRFRGSNLRLTASIGIAFFPEHGDNVEDLVAHADTAMYQAKSNGKNTWSLYDPSRNKAMM
ARMTWRGRIDQALREESLELHFQGIYSTADGELSHVETLVRMRDPADGLIMPGQFIPVAEKTGQILEIDRWVLRQSIGLLAK----HPKLRALAVNISGR
SFDEPGLPQYIQDLLQRHDVEPRRLIVELTETAAVSEMQDAQRFIEALHQTGCLIGLDDFGSGFSTFAYLKYLGVQILKIDGMFIRDLPNNRDNQAFVKA
MIDVAKGLDKLTVAEFVEDAETLAMLREFGVDMAQGYHLDRPSA----------------
>tr|D3SEI7|D3SEI7_THISK Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thioalkalivibrio sp. (strain K90mix) GN=TK90_0517 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------FETTHQHVDGHLIPVH--ISLQLVPRGERPRYVAIVHDISQRKR
NEEALLEALSLLSAMSIGILFEDRQGSIEYVNPAFRRMWAIADEDLVGQPSRVLEHSTHRFHASRHVLHVLDTHEI-SERFEVDLYDGRILTQL--SYPV
HDADERSIGRLWLYEDVTHERQTAQQLVYLAEHDPLTGLYNRHRFQRQLEQAIHTARRRGTHLALIYFDLDEFKTINDTFGHRAGDTVLVRAAGEIASLV
REEEIFARLGGDEFAILVDHAAEREPEGLAERVARAISIPFRFRGQNYRLTASIGIARYPEHGDNVEDLVAHADAAMYQAKDSGKNTWAVFDASRNERML
ERMSWSQRIGKALEGGQFELHFQGIYHLDSGALNHMEALVRMRDPLAPVVMPGQFIPVAEKTGQIVDIDRWVIRESIAHLAR----QPELPGIAINISGR
SFDEPGLPQYITNELSQQGVDPRRLVIELTETAAVSEMQDAQRFIEALQQAGCLVCLDDFGSGFSTFAYLKYLGVQVLKIDGMFVRDLPNNRDNQAFIRA
MVDVARGLDKWTVAECVEDGDTLAMLADLGVDMVQGYHLNRPSP----------------
>tr|K9ERT2|K9ERT2_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Leptolyngbya sp. PCC 7375 GN=Lepto7375DRAFT_1892 PE=4 SV=1
--------------------------------------------------------------ISD---RKQAEARLQMSEQRFRRAIAMAPFPIMIHAED
GEVLHINGTWTELTGFTQKDLPTTQ-VWAQGERATEMLETIAKNYR-LASRGDEDTQ-TINIAKGKQRIWQ-FSSAPLEKADGRRI-AITMAVDITQSCQ
TEKALRDSESIYNQAAVGLANGTLDGKFVDANPRFCEMLGYSREELLAKPISITHP--DDRDQTQVMAHRLFTNEVLFHEKRYLRKNGSFFWSNTGVSIV
KDTQGNPKHTLAVIQDISDRIKAEEKLKHDAFHDELTGLPNRSLLMERLELALKRVKRHHTQLAVLFLDLDNFKVINDSLGHSVGDRLLLAISTRLKGVI
RETDLAARLGGDEFVILLEEIGDAEATMVAERVLEVLQTPLNIANQRLFPGVSIGIALSRQQHYIASELLRDADVAMYEAKRRGRGQYVVFDSTMHLQVV
QRLHLENKLRRALENEEFSLYYQPIVNLKTQKIEAFEALLRWQHPEEGLMLPERFIDIAQEIGLIAPIDEWVLRTACQQLVLWQTYFPEHPGININFLGE
HLKE-SLLVKLEKVLAVHRPVDNSLMIEITESMLVQDCETTQPLLNQLKHFGVGVVIDNFGAGYSCLRHLHQLPVKALKIDQGFVSSMELNGVNQIIAES
IITMCQSLGLTTIAAGVKTRQQLHWLKEIGCNAVQGDYCAEPMGVEEATDLLA-------
>tr|A6F8D9|A6F8D9_9GAMM PAS sensor diguanylate cyclase and phophodiesterase OS=Moritella sp. PE36 GN=PE36_02277 PE=4 SV=1
----------------------------------------------------------------------KQTSELVESEAKLTSIFEYSPVGIFHYDNN
GIIQKINKCFEGILDSDRDTLIGFN-----MLDRLEDTV-LLNMVKQS-LQGKVSVYEGPYTSVSGRFMHLQANFVPLYSSSGEIEGGIGVYNDTTEKQR
STANLKKLSMVVEYSPESILITDISGIIEYVNPKFTAITGFTAAEVLGEKANVFRSSDTPDSVYKNMWATILAGQEWRGELKNCKKNGELFWAKVCIVPV
TN-DGVITHFIGIQVDVTEARIASQKISYQATHDMLTGLINRYEFENLLAQSIMSAQQDNTTHVLCFLDLDQFKIINDTCGHMAGDELLRQLGLLLAENI
KPQDILARLGGDEFAILMTQCGLTQAEKAAQNILELIADQFMWEKNIFSIGASIGLAEINSQTKNTTEILIGVDSACYAAKDLGRNRIHIYHAELLAKRD
GEFRWVNELKYALNENRFELYAQPIVSLSDSQKRIYEVLLRLRTRSGDIVPPGAFLPAAERYNLSNAIDRWVVDHTFA----WMEQHFQVDHLAINLSGA
SLGSNTLLNHIMQQITLHNLPPSMIKFEITETAAISNLRDATLFIKTLSEFGCQFALDDFGSGLSSFAYLKNLPVCTLKIDGMFVKDILDDPIDEAMVKS
INDIGHVMGMKTIAEFVENDAIRQRLQHMGVDFAQGYGIGKPAPINDILQPQR-------
>tr|A6F7G4|A6F7G4_9GAMM PAS sensor diguanylate cyclase and phophodiesterase OS=Moritella sp. PE36 GN=PE36_19900 PE=4 SV=1
----------------------------------------------------------------------QRTAELVQSEAKLSSIFEHSPVGIFHYNKH
GVLLRTNRHFEDIIGADKNGLIGFN-----MLKKVQNAN-LSKAIKSS-LKGQVSTFEGEYISVSHKKSYLEVDLVPLYSNTGEIDGGVGVCDDITLQQQ
NTANLKKLSRVVECSLDGIMITNTQGVIEYVNPSFTQITGYSSTESVGEKSNFFRSTTTTNATYNELWNSISNGDEWSDEVQNQHKNGDLYWAKVTIIPM
TNACGEITHFIGIQVDITKSRIISKQIAYQAKHDMLTGLINRYEFEHQLSDAVCSVQGSQLTHVLCFLDLDQFKIINDTCGHAAGDELLRQIAGLIGDNL
KPNDTLARLGGDEFAVLMRDCQLTEAVVAANEILDKVKKQFIWKKSCFSVGVSIGVAEICNTSGNTSEVLIHADLACYAAKDLGRNRVHTYHDNLLTARD
DEFRWVNEIKEALNEDRFELYAQPIVALQDAQKPIFEVLLRMQDKNGALISPGVFLPIAERYNLSEPIDRWVIDRTLQ----WMKAHSQFDHISINLSGA
SLGDSDLLQHIMTTITQAKVSPQQIMFEITETAAISNLASATIFINTLSTFGCQFALDDFGSGLSSFAYLKNLPVNTLKIDGIFIKDILTNPIDAAMVKS
INEIGHLMKLKTIAEFVENDAIKQKVETIGIDFAQGYGIGKPQPIDKMLTLNQ-------
>tr|A0A090IB71|A0A090IB71_9GAMM Putative membrane associated signaling protein, GGDEF family protein OS=Moritella viscosa GN=MVIS_1010 PE=4 SV=1
----------------------------------------------------------------------QRTAELVQSEAKLNSIFEHSPVGIFHYNKQ
GILLKTNRHFEDIIGAKKDGLIGFN-----MLENIKNKS-LSTAMKSS-LKGQISTFEGEYISISHKNSYLEVDLVPLYSSTGEIDGGVGVCDDITLQQQ
NTSNLQKLSRVVECSLDGIMITNTKGVIEYVNPRFTQITGYSSKESVGEKANFFRSRETRNATYNGLWNSISNGNEWSDEMHNQRKNGELYWAKVTIIPM
TNANDEITHFIGIQVDITESRIIAKQIAYQAKHDMLTGLINRYEFEHQLTDAVCSAQGSKLTHVLFFLDLDQFKIINDTCGHAAGDELLRQVAGMIDDNL
KPNDILARLGGDEFAILMRNCQLKDAVVAANAILNKVKKQFIWKKSCFSIGVSIGVAEISRNSGNTSEVLIHADLACYAAKDLGRNRVHTYNHNLLTTRD
GEFRWVNEIKEALNEDRFELYAQPIVALSDGHKHVFEVLLRMQAKDGKIIEPGTFLPIAERYSLSQPIDRWVFDHTLD----WMREHSQFDHISINLSGT
SLGDDDLLQHIMWNIAQAGLTPQQFMFEITETAAISNLTNATIFINTLSEFGCQFALDDFGSGLSSFAYLKNLPVNTLKIDGIFIKDILTNPIDAAMVKS
INEIGHLMKLKTVAEFVENDAIKQKIKAIGIDFAQGYGIGKPQPIDNMLYLNQ-------
>tr|A2SIL3|A2SIL3_METPP Signal transduction protein OS=Methylibium petroleiphilum (strain PM1) GN=Mpe_A2447 PE=4 SV=1
---------------------------------------------------------------------------------ALREVLDRLGPSVFLLDAD
GVLRYANQAALQAIGATPEQVLGLRFPWQGCKLSQRR---LQQALA-SASRGEASRFDVRLAIRGDTL-AMDFSLLPLYGPDGRVAWLIPSAHDVSERER
ARRQLRLTRHAVEQAHDALFLVGPDGAYRDANAAACRLLGLTRKQLLRLRVHDIDTQVN-ETSWPQRWHEMCERGSSRFETNVRHHDGHEIPVDVSVSLV
TS-DGETFAHVCV-DDLRDRRAAERRIQQLLQFDELTGLPNRQRLFEHLGATLQTS----ATTAVLVLELDRFKRINDGLGPQIGDAVLREVAGRIAATV
RSVDLVARRGGDEFVIVMPAP-SVPAPHVAQTLLETIARPMTIEGHEIHLTCGIGIAMAPADGDRADTLLRRANAALEQAKRLGRNQVNVYAGAPHDDDP
EQMALETALRHALRDEQFELHYQPQVDLAQGRIVGVEALLRWQHPTLGRISPDRFIPIAEETGLIVPIGDWVLRHAIEQAAAWQRARLPPLRMAVNLSAR
QLLQPDLARRIEGLLAATGLDPRRFGVEVTESMLIGNFDQAVQHLRALRALGVEVSLDDFGTGYSSLSYLRRLPVDVVKIDRSLVPDVTAPAEDVSITRA
IITMAHQLQMKVLAEGVESEGQAALLAANQCDQMQGWWFSAAQTAAAIEAMLRE------
>tr|A0A083Z750|A0A083Z750_CITAM Diguanylate cyclase OS=Citrobacter amalonaticus GN=DQ02_10355 PE=4 SV=1
----------------------------------------------------------------------AERKHITESEERFRNAMEYSAIGMALVGTE
GQWLQANKALCQFLGYNQDELRALT---FQQLTWPEDLHK-DLEQLTMLVSGNSYSMEKRYYTRTGEIVWALLTVSLVRHSDGTPLYFIAQIEDINDLKH
TEWVNKRNEITLDSIGEAVVCIDVDLKVTFMNPVAEKMSGWQQENAIGVPLTVLTFGDNGPLMENIYSADMSRSA-IEQEVVLHCRNGGSYDIHYSITPL
STLDGGNIGSVLVIQDVTESRKMLRQLSYSATHDALTHLTNRASFENKLKLLLQTVRSAHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELAQLMLSML
RSSDVLARLGGDEFGLLLPECNIESARFIATRIVNAVNDHFMWEGRLHRIGASAGITLIDENNCQAVEVMSQADIACYASKNGGRGQVTVYEPQQEQAHH
ERMMSLDEQWRMIKDNHLLMVARGVASPRIPERNFWLISLRLWTSEGEVMEEQAFRASLADPALSHALDRRVLHEFFHHAAPAVASK-G-LSVALPLSVA
GLISTTLIDELLAQLEQSTLPGRLLHLIVPAEALLLNPQESTKAIQTLRQAGCHIIVSQIGRDLQIFNLMTKSLADYLLLDSELSASIHGNMMDEMLVSI
IQGHAQRLGMKTIAGPVQTPIVMDTLSGIGIDQIYGDIIAEAQPLDLLL-----------
>tr|A8AEF1|A8AEF1_CITK8 Uncharacterized protein OS=Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) GN=CKO_00712 PE=4 SV=1
----------------------------------------------------------------------AEQKNITESELRFRNAMEYSAIGMALVGTE
GQWLQANKALCQFLGYSQDELRALT---FQQLTWPEDLHN-DLEQLNMLVRGNSYSMEKRYYTRDGDVVWALLAVSLVRHSDNTPLYFIAQIEDINDLKH
TERVNKRNEITLDSIGEAVVCIDVDMNVTFMNPVAEKMSGWQQEHAIGIPLTVLTFGDNGPLMENIYSADMSRSA-IEQDVVLHCRNGGRYDIHYSITPL
STLDGGNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFESHLKEILLTVRDTRQHHALVFIDLDRFKAVNDSAGHAAGDALLRELAALMLSML
RSSDMLARLGGDEFGLLLPDCNIDSARFISTRIVNAINERFTWEDREHPIGASAGITLINNANRLAADVMSQADIACYASKNNGRGRVTVYEAQQEQAHS
ERVTSQDEQWRIIKDNPLLMIARGVASPRIPECGFWLISLRLWTSDGEIMEEQAFRAGLTDPELSHALDRRVFQTFFQHAASTVASK-G-VSIALPLSAA
GLSRATFIDELLEQLERSPLPPRLLHLVIPAHVLMQESDKAIPAIQILRQAGCRIVLSQVNRDLALFDCLSAHMADYLLLDSELCASLHGNLMDEMLVSI
IQSHAQRLGVRTIAGPVQMPLIMDALSGIGIDLIYGDVIADAQPLDLLL-----------
>tr|A0A064DLF2|A0A064DLF2_CITFR Uncharacterized protein OS=Citrobacter freundii MGH 56 GN=AF42_02493 PE=4 SV=1
----------------------------------------------------------------------AERKHISESESRFRNAMEYSAIGMALVGTE
GQWLQANKALCQFLGYSQDELRSLT---FQQLTWPEDLNN-DLEQLEMLTRGNSYSMEKRYYTREGEVVWALLAVSLVRHSDDTPLYFIAQVEDINDLKH
TEWINKRNEITLDSIGEAVICIDVDMNVTFMNPVAEKMSGWQQESAIGIPLTVLTFGDNGPLMENIYSADMSRTA-IEQEVVLHCRNGNSYDIQYSITPL
STLDGGSIGSVLVIQDVTESRKMLRQLSYSASHDDLTQLANRVSFENHLKQLLHTVHDAHQRHVLVFIDLDRFKAVNDSAGHAAGDALLRELSSLMLSML
RSSDMLARLGGDEFGLLLPDCNIESARFISGRIISAVNDHFMWEGRLHRIGASAGITLIDEKNHIATDVMSQADIACYAAKNSGRGRVCVYEPQQSQAHA
SRQLSLDEQRHTITHNPMLMIARGVASPRIPEFSFWLISLRLGTAEGEVIEEHTFRNGLVDPALNQALDRRVFSEFFQNAASAVASK-G-LSIALPLSAA
GLLNSELIDELLDQLQHSPLPPRLLHLTVPASAIKTNSTQAISALHRLRQFGCRIVLSQVGRDLELFDNLKYHIVDYLLLDSELSASAHGDLIDEMWVSI
IQGHAQRLDIKTIAGPVQLPLIMDALSGIGIDMIYGDIIADAQPLDLLL-----------
>tr|I6H1Q1|I6H1Q1_SHIFL Sensory box protein OS=Shigella flexneri 1235-66 GN=SF123566_3453 PE=4 SV=1
----------------------------------------------------------------------AERKHISESESRFRNAMEYSAIGMALVGTE
GQWLQANKALCQFLGYSQEELRALT---FQQLTWPEDLNN-DLEQLGMLVRGNSYSMEKRYYTRAGDVVWALLAVSLVRHSDNTPLYFIAQVEDINDLKH
TEWMNKRNEITLDSIGEAVICIDADMNVTFMNPVAEKMSGWQQDDAIGIPLTVLTFGDNGPLMENIYSADMSRTA-IEQEVVLHCRNGGSYDIQYSITPL
STLDGGSIGSVLVIQDVTESRKMLRQLSYSASHDDLTHLANRVSFENHLKQLLQAVHDTHQRHVLVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSML
RTSDVLARLGGDEFGLLLPDCNIESARFISGRIINAINEQFRWEDRLHRIGASAGITLIDEKNYIATEVMSQADIACYAAKNSGRGRVCVYEPQQSQTHV
SRLLSFDEQKHIIAHNPMLMIARGVASPRIPEFSFWLLSLRLGTEDGDVIEEHILRTGLVDPALNHALDRRVFNEFFQHAAAAIASK-G-LSIALPLSAA
GLLSTELVDEMLAQLQRSSLPPRLLHLTIPAGVMKSHPAQSLSAIQRLRHAGCRIILSQVGRDLEIVENLKFHTVDYLLLDSEISASVHGNLMDEMWVSI
IQGHAQRLDIKTIAGPVQMPLIMDALSGIGIDMIYGDIIADAQPLDLLL-----------
>tr|D6JBW8|D6JBW8_ECOLX Putative uncharacterized protein OS=Escherichia coli B354 GN=ECEG_01394 PE=4 SV=1
----------------------------------------------------------------------AERKHISESETRFRNAMEYSAIGMALVGTE
GQWLQSNKALCQFLGYSQEELRGLT---FQQLTWPEDLNK-DLQQVEKLISGNTYSMEKRYYNRNGDVVWALLAVSLVRHTDGTPLYFIAQIEDINELKR
TEQVNQQNEITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPLTVLTFGDNGPLMENIYSADTSRSA-IEQDVVLHCRSGGSYDVHYSITPL
STLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSML
RSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDHFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRVTIYEPQQATAHS
ERAMSLDEQWRMIKENQLMMIAHGVASPRIPQRNLWLISLKLWSCEGEIIDEQTFRRRFSDPALSHALDRRVFHDFFQQAAKAVASK-G-LSIALPLSVA
GLSSATLVNELIEQLENSPLPPRLLHLIIPADAILDHA----ENVQKLRLAGCRIVFSQVGRDLQIFNSLKANMADYLLLDGELCANVQGNLMDEMLITI
IQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLIYGDVIADAQPLDLLV-----------
>tr|B1ER45|B1ER45_ESCAT Sensory box-containing diguanylate cyclase OS=Escherichia albertii (strain TW07627) GN=ESCAB7627_2245 PE=4 SV=1
----------------------------------------------------------------------AERKHISESETRFRNAMEYSAIGMALVGTE
GQWLQANKALCQFLGYSQEELRALT---FQQLTWSEDLNK-DLQHVEKLVNGNTYSMEKRYYTRNGDVVWALLAVSLVRHADGTPLYFIAQIEDINDLKR
TEQVNKQNEITLDSIGEAVVCIDLAMKITFMNPIAEKMSGWAQEEALGVPLTVLTFGDNGPLMENIYSADTSRSA-IEQDVVLHCRNGGSYDVHYSITPL
STLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRTSFEKQLRTLLQTVNSTHQRHALVFIDLDHFKAVNDSAGHAAGDALLRELASLMLSML
RSSDLLARLGGDEFGLLLPDSNIESARFIATRIIGAVNDHFIWEGHVHRVGASAGITLIDGCNHQAAEVMSQADIACYASKNGGRGRVTVYEPQQATAHS
ERVMPPDEQWLMIKENQLMMFAHGVASPRIPECNLWLISLQLQNDEGNVIDEHVFRHGFSDPALSHALDRRILHEFFQQTAKSAADK-G-LSIALPFSVA
GLSSVTLVDELLEQLEKSPLPPRLLHLIIPAEAIIDHA----QAIQKLRLADCRIVLSQVGRDLQIFNTLKANMADYLLLDSELSASVQGNLMDEMLISI
IQGHAQRLGVKTIAGPVALPLVMDTLSAIGVDLIYGDVIANIQPLDLLV-----------
>tr|V2KLV1|V2KLV1_SALET Diguanylate cyclase OS=Salmonella enterica subsp. enterica serovar London str. CFSAN001081 GN=CFSAN001081_24421 PE=4 SV=1
----------------------------------------------------------------------TERKHITESESRFRNAMEYSAIGMALVGTE
GQWLQVNKSLSHFLGYSQDELRTMT---FQQLTWPEDLNN-DLEQLNMLVRGNSYSMEKRYYTRNGDVVWALLAVSLVRHKDNKPLYFIAQIEDINDLKQ
SEQENQRNEITLDSIGEAVVCIDVAMNITFMNPIAEKMSGWRQEDALGTPLTVLTSGDKGPLLEDIYRADRSRSD-MEQEIVLHCHNGGSYDIHYSITPL
STLDGDKIGSVLVIQDVTESRKMLRQLSYSATHDALTQLANRASFEKQLQQRLQTIQESPQHHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSML
RSGDLLARLGGDEFGLLLPDCNSDSARFIATRLINAINEHFMWEGRLHRIGASAGITMINEHNCQLTEVVSQADIACYAAKNSGRGRLTVYEPQHAL-TS
SKMMPLEEQWHMIKNNHLLMLARNVAPPRTPETSFWLVSLRLWTSEGEVLEERAFRAGLADSALHHALDRRVFHEFFHHAATAVASK-G-LSVALPLSAA
GLYSATLIDELLEQLEHSPLPPRLLHLIIPADVIVKQAQTAAATLRKLRQRGCQVILSHVGRDLQLFNLLPLHIVDYLLLDSDLIANVHESLMDEMLTSI
IQGHAQHLDIKTLAGPVQNPQVLDTLSRIGVDLIYGDTIAEAQPLDLLL-----------
>tr|E3GCV4|E3GCV4_ENTLS Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Enterobacter lignolyticus (strain SCF1) GN=Entcl_1624 PE=4 SV=1
----------------------------------------------------------------------AERKHISESEERFRNAMEYSAIGMALVGTE
GQWLQVNKALCKFLGYSQNELRTMT---FQQLTWPEDLNS-DLEQLEQLVRGNSYSMEKRYYTRKGDVVWALLAVSLVRHADGSPLYFIAQVEDINDLKQ
TEWVNKRNEITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWTQPEAIKQPLNVLTFGDNGPLMENIHSGDISRTD-IEQDVVLHCRNGGKYDIHYSITPL
STLDGQNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENNLKRLLQTVQETRQRHVLVFIDLDRFKAVNDTAGHAAGDVLLRELSSLMLSQL
RTSDILARLGGDEFGLLLPDCNIESARYITTRIIDAINDRFMWEGQVHRIGASAGITVIDEHNCQSSEVMSQADIACYASKNNGRGIVTVYEPQQEGLLP
SRMMTLDEQWRIIKDNHLVLMARGVASPRVPESHFWLLSLRLWNSEGEMLEEQAFRKGLSEPELIHALDRRIYQAFFRDGAAEVAAR-G-ISVTLPLSAV
GLASPTLVDELLEGLEQHAVPPRLLHLIMHADSL--PQAGVQDGIARLRAAGCKIILSHVGQDMDLFNHLTPGQVDYVMLDPEIISNVHVNLMDEMMVTI
VQGHAQRLGMKTIAGPTNQALMMDTLSGIGVDLIYGDLIAHNQPIELML-----------
>tr|A0A084ZLT0|A0A084ZLT0_9ENTR Sensory box/GGDEF family protein OS=Trabulsiella guamensis ATCC 49490 GN=GTGU_04496 PE=4 SV=1
----------------------------------------------------------------------AERKHITESESRFRNAMEYSAIGMALVGTE
GQWLQANKALCQFLGYSQDELRALT---FQQLTWPEDLDS-DLVQLDMLVKGNSYSMEKRYYTRKGDVVWALLAVSLVRHADGSPLYFIAQIEDINDLKH
TEWVNKRNEITLDSIGEAVLCTDIHMNVTFMNPVAENMSGWTQEQALQQPLNVLTFGDNGPLMENIYSGDFSRSD-IEQDLVLHSRHGGSYDIHYSITPL
STLDGHNIGTVLVIQDVTESRKMLRQLSYSASHDALTQLGNRVSFENHLKRLLHNVHETHQTHALVFIDLDRFKAVNDTAGHAAGDALLRELSALMLSML
RTSDILARLGGDEFGLLLPDCNTESARFTATRIITAINDQFRWEDRTHRVGASAGITLIDENNSVASEVMSQADIACYTSKHGGRGMVTVYEPQQDNPP-
ARTMPPDEKWRIIKENHLVFMARSVASPRIPESHFWLLSLRLWTSEGEMLEEKAFRNSLSESELLRALDRRLLSEFFLQWAPKVAAK-G-ISVSLPLSST
SLSSVALIDELFSQLTESQIPPRLLHFVISSDCLLSEDRVMAQSILRLRQAGCKLILSHPGQDLEIFNRLTPDSADYIMLDPDTVVNVHLNLMDEMMATI
VHGHAHRLGMKTIAGPTNESLVMDTLSGIGIDMIYGDTISQNQPLELVL-----------
>tr|A0A0D0NRB5|A0A0D0NRB5_CITRO Citrobacter rodentium strain ATCC 51459 Contig72, whole genome shotgun sequence OS=Citrobacter rodentium GN=TA05_04160 PE=4 SV=
----------------------------------------------------------------------AERKHITESEERFRNAMEYSAIGMALVGTE
GQWLQVNKALCQFLGYSQDELRAMT---FQQLTWPEDLNN-DLGQLDMLVRGNSYSLEKRYYTRSSEVVWALLAVSLVRQPDGTPLYFIAQIEDINDLKQ
TERAN--NEITLDSIGEAVVCIDVDMKVTFMNPVAETMSGWQQENAIGMPLTVMTFGDSGPLMENIYSADMSRSA-IEQDVVLHCRNGGSYDIHYSITPL
STLNGGNIGSVLVIQDVTESRKMLRQLSYSATHDALTHLTNRPSFENKLRQLLQTVRGSHQHHALVFIDLDRFKAVNDSAGHAAGDALLRELSQLMLSTL
RPGDVLARLGGDEFGLLLPDCNIENARVITTRIITAVNDHFMWEGRLHRVGTSAGITLIDDNNCQPVEVMSQADIACYASKNSGRGRVTVYEPQQEMAAH
ERMMSLDEQWHMIKENHLLMIARAVASPRIPERSLWLVSLRLWTSEGEVMEEQAFRTGLADPALTHALDRRVFHEFFHHAAPAVARK-G-LSIALPLSVA
GLTSTTLMDELLRQLELSPLPGRLLHLIIPAEALLLHPQESVSAMQKLRQAGCRIILSQISRDLQIFNLMSKNMADYLLLDSDLSASIHGNLMDEMLVSI
IQGHAQRLGCKTIAGPVQAPVVMDTLSGIGIDQIYGDIIAEAQPLDLLL-----------
>tr|A4WCB7|A4WCB7_ENT38 Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Enterobacter sp. (strain 638) GN=Ent638_2681 PE=4 SV=1
----------------------------------------------------------------------AERKHITESEERFRNAMEYSAIGMALVGID
GQWLQTNKALCEFLGYSQTELQSLT---FQQLTWPEDLHT-DLESLEQLARGNSYSLEKRYYTRNGEVVWALLTVSVVRHTDGSPLYFIAQIEDINDLKH
TEWVNKRNEITLDSIGEAVLCTDVDMHVTFMNPVAEKMSGWTQQEAMGQPISVLTFSENGPPMENIHSGDMSRSD-INQDVVLHSRTGGTFDIHYSITPL
STLDGQNIGSVLVIQDVTESRKMLRQLSYSASHDGLTHLANRVSFESHLKRLLQTVHDTHQRHALVFIDLDRFKAVNDTAGHAAGDALLRELSSLMLSML
RSSDVLARLGGDEFGLLLPDCNVESSRYIAGRIIHAINDQFMWEGRLHRIGASAGITLLDDSNYQVAEVMSQADIACYASKNNGRGVVTVYEPQQERIHS
ARMMSLDEQWHMIKDNQLLMTGRSVASPRIPESNFWLISLRLWTSQGDVVEEQAFRSGLMEPDLLHALDRRIFQTFFRTYATQVATK-G-MGVALPLSAE
GLSSTTLVSELLDLLEKSPLQGRLLHLVIPVETLQNQDVHIQNGLQKLRLAGCRIVLCHVGRNMDVFNHLTPHMADYLLLDPELVTNVHGNLMDEMMVSI
IQGHAQRLGMKTIAGPSNQPLMMDTLSGIGIDYIYGDCIAEPQPLEILL-----------
>tr|K8C4R6|K8C4R6_9ENTR Uncharacterized protein OS=Cronobacter malonaticus 681 GN=BN131_938 PE=4 SV=1
----------------------------------------------------------------------EERKLITESETRFRNAMEYSAIGMALVSTE
GGFLQVNKALCTFLGYTPEQLANMS---FQQLTYPEDLHA-DMEQVEKLLNGNNYSLEKRYYTRAGDVVWALLAVSIVRQRDGSPLYFIAQVEDITELKR
TEWVNKRNEITLDSIGEAVICTDVDMNVTFMNPVAEKMSGWRQEEAIGQSIAILTFGDNGPLLDDVHSGEATGAG-IEQDVVLHCRSGGNYDIHYTITPL
STLEGENIGSVLVIHDVTESRKMLRQLSYSASHDGLTHLANRVSFETHLKRLLQSVSDTHQRHALVYIDLDRFKAVNDTAGHAAGDALLRELASLMLGML
RTTDVLARLGGDEFGLLLPDCSLENARTICERIVAAINEPFVWESRLHRIGASAGITIIDASNNQAQDVMSQADIACYTSKNAGRGVVTVYEPHQQQLHN
GRTLTAQEQQRMINEHHHVLMVRPVASPRVPEASFWLLSLRLWTSEGEMIEEHSFRAGLNDPELMQALDTRMLTDFFRDHAASVAQK-G-VGVALTLSGA
TLLNAQRLDALLAQLAASPLPPRLLHLVINSEVLMQDAATARRHLARLREAGCRVVLSHIGRELEVFEHISAACADYIMVASDLVADAHASLMDEMLLTI
VLGNARRLGLQTIAGPADQQSLLETLANIGIDLVYGETVAQTQPLTARL-----------
>tr|A0A085HPQ0|A0A085HPQ0_9ENTR Putative diguanylate cyclase OS=Leclercia adecarboxylata ATCC 23216 = NBRC 102595 GN=GLAD_00855 PE=4 SV=1
----------------------------------------------------------------------AERKHITESEERFRNAMEYSVIGMALVSTD
GQWLQANKALCQFLGYTQAELRSLN---FQQLTWPEDLES-DLAQLDQLLKGNSYSLEKRYYTRNGEVVWALLAVSLVRHADGTPLYYIAQIEDINDLKH
TEWVNKRNEITLDSIGEAVLCTDVNMNVTFMNPVAEKMSGWLQQDALSQPISVLTFGDNGPLMENIHSGDMSRSD-IEQDVVLHSRNGGSYDIHYSITPL
STLDGQNIGSVLVIQDVTESRKMLRELSYNASHDALTHLANRVSFEACLKRMLLTVQDTRQRHALVFIDLDRFKAVNDTAGHAAGDALLRELSSLMLSML
RSTDMLARLGGDEFGLLLPDCNTESARYIAGRIIDAINDHFMWEGRLHRIGASAGITQIDERNNQASEVMSQADIACYSSKNNGRGVVTVYEPQQERTLE
-ATISLDEQWHMIKDNHLLMIARSVASPRIPESTFWMLALRLWTNDGEMLEEQAFRAGLAEPELIHALDRRILQEFFRNFATPLTSK-G-TGVALPLSTA
GLASATLVDELLEMLRASPLQPRLLHLVVNVSVLALEDEHTRNNLDKLRQAGCRIILSHVGRDMEVFNHLSAQMADYLLLDPDLVVNVHANLMDEMLVTI
IQGHARRLGIKTIAGPSNQPIMMDTLSGIGIDYIFGNTIGEPQPLELLL-----------
>tr|H5UXB0|H5UXB0_ESCHE Putative diguanylate cyclase YegE OS=Escherichia hermannii NBRC 105704 GN=yegE PE=4 SV=1
----------------------------------------------------------------------EERKNISESETRFRNAMEYSSIGMALVSID
GRWLQVNKSLCQFLGYTPEKMTSMT---FQQITWPEDLHD-DLEQLESLIKGNSYSLEKRYFTQSGEVVWALMSVSVVRDSNGTPLYFIAQIEDINDLKH
TEWMNKRNEITLDSIGEAVICTDIEMNVTFMNPVAEKMSGWTQEQAMGHPLSVLTFGDKGPLMENIHSGDVSRTA-IEQDVVLHCRSGGSYDINYTVTPL
STLDGQNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQSVGENHQRHALVCIDLDRFKAVNDTAGHAAGDALLRELASLMLGML
RTTDILARLGGDEFGLLLPDCGIENAYTISSRLIQAVNDHFMWEGRLHRIGASAGITLIDANNNLASDVMSQADIACYASKNKGRGVVTIYEPQQQHLQQ
QRLLAQEEQHRIIHNNHMMLLARAVASPRIPETNFWLLSLRLWTSEGNVLEEAAFRSGVSDPALLCDLDWRVFNDFLKNHAAAIALK-G-FGVALPLSPQ
GIANDDLINQMLATLSTSSLPPRLLHLTIHSDVLLTDDDRATKNMIKLRNAGCRVIVSQVGRDMDIFNQLNRQMCDYVMIAPELVMDVHTNLMDEMMVTI
IQGHAQRLGLKCIAGPADQAMIMDTLSGIGIDMIWGDTIAQTQPLDMLL-----------
>tr|A0A071LP70|A0A071LP70_9ENTR Diguanylate cyclase OS=Mangrovibacter sp. MFB070 GN=DT73_22755 PE=4 SV=1
----------------------------------------------------------------------EERKNITASETRFRNAMEHSAIGMALVGVD
GRWLQVNKALCKFLGYTHDQLRNLT---FQQITFPEDLHT-DLQYMDKLLSGNSYSMEKRYYNSKGNIVWALLAVSVVRDANNTPLYVIAQVEDINDLKH
SEWMNKRHDITLDAIGEAVICTDVDMRITFMNPVAEKMSGWPQEQAFGQYISVLTFGENGPAMENIYSG---RSA-MEQDVILHSRTGDSFDIHYSITPL
STLDGESIGTVLVIHDVTESRKMLRQLTYSASHDGLTHLANRASFENHLKRLLASAVENRQQHALVFIDLDRFKAVNDTAGHAAGDSLLRELSTLMLSLL
RNNDFLARLGGDEFALLLPNCSVESARHIAEHITSMINDHFIWEEQTYRIGASAGITIIDEHNYDANEVLSQADIACYASKNSGRGRVSVFEAKKHTNQK
K-QLSAEEQQAIIAHNPVLITARPVASPRIPECSFYLLGVQLWNNAGDMIEENHFRAALSSTDLHKALDLRMIELFFKEHARRVIVK-G-FTVALSLSVA
GLNSGTVVETLVRLLRETRFPPARLMVIVENQVVGRIDGPVRQGLEQLVDAGCVLALSQVGDDLDIFNQIPRHLFKAILLEQSLVQHVHENLMDEMMVTI
IQGHAQRLKLQTIGGPVAQAITMDTLSGIGMDLIFGDSIGPQQPLEVLL-----------
>tr|A0A059ICQ4|A0A059ICQ4_ENTAG Diguanylate cyclase OS=Pantoea agglomerans Eh318 GN=T296_09380 PE=4 SV=1
----------------------------------------------------------------------REKLHITDSETRFRHAMEYSAIGMALVAPH
GSWLQVNRSLCQILGYPAEELKRLT---FQQITHPDDLSL-DLQHANRLLAGDTYTFEKRYFRKDGEIVWARLTVSLVRDGNQEPLYFIAQIIDISELKQ
SEQVNRRNEITLDSIGEAVISTDKEMRVAFMNPVAEKMSGWSQEQAAGQPLELLTQGRNGPEVESLLLCQLPTPG-LAEDLVLHTPDGGHIDIHYSITPL
RSEAGLEQGAVMVIQDVSESRKLMKRLSYSALHDTLTRLPNRASFELQLKRLLFDAAEHQHQHVLVFIDLDKFKAVNDSAGHAAGDALLRELSDLMQHPL
RSSDFLARLGGDEFALLMPDCDIAQAHDVVQRIVAAVNDRFQWLGRLYQVGASAGVTQISAENCQSSDVLSQADIACYNAKRSGRGRLVVYEQHRLPLSN
H--Q--GMDAAMIDALQIELPAWAVAPPKTPQAFIWLLEVQLLTADGLLLDETLLRNNLPDETLRRRLDNNILEAFFRHDVQRLNNK-G-IPVILPLNAQ
VLSDAAFVQQLCQRFVAAGLSSSGCGFAFPAASVLSQGDQLYAALLQLRQCGCRIVLQHFGRNLDAFNLLSDEVVDYLVLAPELVANVHNNLMDEMLLTI
IQGQATQRNISVLAGPVSVPALLSTLANLDVNGVWGSAVAERQPLRSLA-----------
>tr|H8DQD5|H8DQD5_9ENTR Putative diguanylate cyclase OS=Pantoea sp. Sc1 GN=S7A_06965 PE=4 SV=1
----------------------------------------------------------------------REKLHITDSETRFRHAMEYSAIGMALVAPQ
GNWLQVNRSLCQILGYPAEELKRLT---FQQITHPDDLAL-DLQQVNQLLEGDTYTFEKRYFRKDGEIVWARLTVSLVRDGDTAPLYFIAQIIDISELKK
SEQVNRRNEITLDSIGEAVISTDEAMRVAFMNPVAEKMSGWSQEQAAGKPLELLTQGQTGPEVENLLLCQLPTPD-LDEDLVLHTPDGGHIDIHYSITPL
RSEAGLEQGAVMVIQDVSESRKLMKRLSYSALHDTLTRLPNRASFELQLKRLLFDAAEHHHQHVLVFIDLDKFKAVNDSAGHAAGDALLRELSELMQHHL
RSSDFLARLGGDEFALLMADCQVDQARDVVQRIVAAVNDRFQWQERRYQVGASAGVTQISADNCISGDVLSQADIACYNAKRSGRGRLVVFEQHRLPLPN
P--Q--GVDAAMIDALQIELPAWAVAPPKTPQAFIWLLEVQLLTAEGILVDETLLRHNLPDETLRRRLDSNIIEAFFRQDVGTLNKK-G-IPVILPLSEE
LLGDAAFVQQLCQRFVAAGLASSRCGFAFPAASVLSKSDRLYTALLQLRECGCRIALHHFGRNLDAFNLLSDEVVDYLVLAPELVANAHTSLMDEMLLTI
IQGQATQRHISVLAGPVSVPAVLSTLADLDVDGVWGSAVTERQPLRSLA-----------
>tr|A0A0A6W277|A0A0A6W277_9ENTR Uncharacterized protein OS=Pantoea stewartii GN=OI73_00975 PE=4 SV=1
----------------------------------------------------------------------HETRHISESETRFRNAMEYSAIGMALVSPE
GRWLQVNKSLCDTLGYPEYELKNLT---FQQITHPDDLGI-DDGKMDKLLAGLSFTLEKRYFRKDHEIVWVRLTVSLVRDSEQQPLYFIAQIVNISELKQ
SELVNQRNEITLDSIGEAVISTDQAMRVTFMNPVAEKMTGWSQEAAVGRPVELLTHGRHGAPVENLMINPTHAPY-LSEEWVLHTLNGEHIDIHYTITPL
KSESGTERGAVMVIQDVSESRKVMKRLSYSALHDTLTRLPNRASFELQLKRLLSDAAEHQHQHVLVFIDLDKFKAVNDSAGHAAGDALLSELSDLMRHHL
RSTDFLARLGGDEFAVLMPECLVDQARDVVQRIVRAVNDCFEWLGRAYQVGASAGMTQISPNNCQSSDVLSQADIACYNAKRSGRGRYMVYEQHPLALTS
H--H--SLDQATLDALQVELQVWAVAPPGKPHASVWLIEVQLFTREGLLVDEHLLRNNLTDAALKQRLEDNIVEAFFRHRIAAMSQK-G-IALILPVDVN
ALYNPVFVEKLCVRFAESGLANSNSGIALHAASVLSGGEQLLGTLMKLRQAGCRIVLQQFGRNLDAFNQLTGKVVDCLILAPELVANLHNNLMDEMLISI
IQSQTNERNIILLAGPVSVPAVLTTLTSLDVDGVWGSAVAERQPLSKLS-----------
>tr|D4GIE5|D4GIE5_PANAM YegE OS=Pantoea ananatis (strain LMG 20103) GN=yegE PE=4 SV=1
----------------------------------------------------------------------HEKRHISESETRFRHAMEYSAIGMALVSAE
GRWLQVNKSLCDTLGYPEHELTQLT---FQQITHPDDLYD-VQGRLEKLLQGYSYTLEKRYFRKDGEIVWVRLTLSLVRDQAQQPLYFIAQIIDISELKQ
SEQVNKRNEITLDSIGEAVISTDQDMCVTFMNPVAEKMTGWSQEAAAGKPVELLTHGRHGPEVDNLLLCHVPAPY-LSEEWVLHTLNGEHIDIHYSITPL
KSESGTERGAVMVIQDVSESRKVMKRLSYSALHDTLTRLPNRASFELQLKRLLSDAVEHQNQHVLVFIDLDKFKAVNDSAGHAAGDALLSELSDLMRHRL
RGSDFLARLGGDEFAVLMPECSLDQARDVVQDIVRAVGDCFEWLGRAYQVGASAGITQINAQNCQSSDVLSQADIACYNAKRSGRGRYKVYEQHALALMS
H--H--SVDLATLDALQVDMQVWAVAPPGKPHASVWLVEVQLFSPEGLLIDEHLLRNNLTDDMLKRRLEDNIVNAFFRQQIATMSQK-G-IALILPLDVH
ALYDPAFVDNLCLRFAESGLARSHSGIALNASSVLSSGDGLIGALMKLRQAGCRIVLQHFGRNLDAFNQLTGKVVDCLILSPELVANLHNNLMDEMLISI
IQSQTSQRDITLLAGPVSVPAVLTTLISLEVDGVWGSAVAERQPMSRLA-----------
>tr|A0A0A1AYL8|A0A0A1AYL8_9ENTR Uncharacterized protein OS=Pantoea sp. PSNIH2 GN=PSNIH2_05030 PE=4 SV=1
----------------------------------------------------------------------EEKKHISESEQRFRNAMEYSAIGMALVTPN
GNWLQVNQALCRLLGYQPHALQKLS---WQQITWPDDLAA-DLQQAESLLRGNYYTLEKRYIRQDGEVVWVLQAVSLMRDLEGNPLYFISQIEDISGLKQ
SQAENQRTEITLDAIGEAVISTDEELRVTFMNPVAEQMSGWTQEQAEGKPIDILTHGAHGPEMENILRSNLPVTE-LDRDLILHNASGEQFAIHYSLTPL
KTLTGENIGSVLVIQDVSESREMLKRLHYSASHDMLTRLPNRTSFEHQLKRLLLSAAEQ--QHVLAFIDLDRFKAVNDSAGHAAGDALLRELAEIMSHLL
RGNDFLARLGGDEFGLLLPDCGIGDASNVVQRIVTAINDRFLWEGKLHRIGASAGLTQIDAHNNHSSEVLAQADLSCYNAKHNGRGQLSVYETRLQQSQV
T--L-SHEDIVRLIEQPMRWQAWAVCAPHTTQANFHLLQPRLTDSQGHEIDVEAFRASLADEALCERLDRALLDSFFSRHATGVAHK-A-LNVVLPLSGE
SLLNSRTLSQLIDTLAAGPLRGERVIISLETSALLNHTEALRPVLLQLRQLGCPILLRHFGRNLEAFERLPQADIDFLQLAPDLIANVHFSLMDEMLVSI
INGQAQRLNIATVAGPVELPVALTTLASIGINAVWEPAVNGGEPLCALL-----------
>tr|W0UIQ4|W0UIQ4_YEREN Putative inner membrane protein OS=Yersinia enterocolitica (type O:5) str. YE53/03 GN=YE5303_08631 PE=4 SV=1
----------------------------------------------------------------------MEKEHIVESENRFRNAMEYSAIGMALVSPE
GKWMQVNQALCKLLGYRQETLLTLT---FQQITHPEDLSA-DLKLLDDLYHGPSYSMEKRYIRSDGEVVWALLVVSVVRDHEQQPLYYISQVEDINDLKK
SEIVNRRTEITLDSIGEAVVCTDQEMKITFMNPVAEKMTGWANTIALGQPIHIITDGIDGPEIDNPIEHCLTYSS-LNESMVLHHRDGQHYDIQESVAPL
KTLEGTIVGAVLVFQDVGESRAMMRKFSHSASHDNLTGLPNRANFENKLKAASQKSIDFDQQHALAFLDLDYFKAVNDTAGHPAGDALLKELSQLMRQHL
RNSDCVARLGGDEFGLLMLNCTLPHAKAITQSLVSMINGHFYWEDKLYRIGASAGVTQISSSNSQRSEIMAQADIACYTAKHSGRGQVYLYQPRQKQLLR
QHLLSREDVESILSENQLLLQVTPTAPPKTPLVCFYQVSFEIDRPQSPLVSQSAFEEAATLYNLLPKVDSWICEQLLVEHAQAIHQK-G-LALAIPLSEL
ALLKEDFRQSLLTLVQQTLLPPQSLYWMIDESTLLQYPFAIGNFLAKLQQLGCKLIVKEFGHNLNDFELLAEHRIDYLKFNSELIAHIHINQMDEVLISI
INGTAQRANIATLAGPVELAPTLSKLIDIGVDLADGTMIGRTEPLSEVL-----------
>tr|C4SIA6|C4SIA6_YERMO Putative uncharacterized protein OS=Yersinia mollaretii ATCC 43969 GN=ymoll0001_40130 PE=4 SV=1
----------------------------------------------------------------------MEKEHIIESENRFRNAMEYSAIGMALVSPE
GKWMQVNQALCKLLDYSQETLLTLT---FQQITHPEDLSA-DLKLLDDLYHDPSYSMEKRYIRSDGEVVWALLVVSVVRDHQQQPLYYISQVEDINDLKK
TEIINRRTEITLDSIGEAVVCTDQEMKITFMNPVAEKMTGWANTIALGQPVHIITHGVDGPEIENPIEHCLNYSS-LNESIVLHHRDGQYYDIQESVAPL
KTLEGGVVGAVMVFQDVGESRAMMRKLSHSALHDNLTSLPNRANFENKLKAAIQVSVELNQQHALAFLDLDYFKAVNDTAGHPAGDALLKELSQLMRQHL
RNSDCVARLGGDEFGLLMLNCTLPHAKAITQSLVSMINGHFYWEDKLYRIGASAGVTQISSSNNQRSEIMAQADIACYTAKHSGRGQVFLYQPRQKQLLR
QHLLSKEDVENILSESQLTLQLTPTAPPKTPLVCFYQVSFVVTRPQNMNVSQAAFQEAALLYGLLPQMDGWVCEQLLVAHAEAINRK-G-LALAIPLSEI
ALLKEDFRQSLLSLVQQTPLPPQSLYWMVDESTLLQYPFAIGNFLAKLQEQGCQLIVKEFGHNLNDFELLAEHTINYLKFNSDLIAHIHINQMDEVLVSI
INGTAQRANIATLAGPAELPPTLSKLIAIGVDLADGETIGRTQPLSEVL-----------
>tr|A0A094SLL7|A0A094SLL7_YERFR Diguanylate cyclase domain protein OS=Yersinia frederiksenii ATCC 33641 GN=DJ58_2016 PE=4 SV=1
----------------------------------------------------------------------IEKEHIIESENRFRNAMEYSAIGMALVSPE
GKWIKVNKALCKLLGYSQETLLTLT---FQQITHPEDLSA-DLKLLDDLYYDPSYSLEKRYIRSDGEIVWTLLVVSVVRDHEQQPLYYISQVEDINDLKK
TEIMNRRTEITLDSIGEAVVCTDQEMKITFMNPVAEKMTGWANTIALGQPIHIITDGVDGPEIENPIEHCLTYSS-LNESMVLHHRDGQYYDIQESVAPL
KTLEGGIVGAVLVFQDVGESRAMMRKLSHSASHDNLTGLPNRTNFENKLKVAIQKSVDQDQQHALAFLDLDYFKAVNDSAGHPAGDALLKEISQLMRQNL
RNSDCVARLGGDEFGLLMLNCTLPHSKAITQNLVSMINDHFYWENKLYRIGASAGVTQISSSNSQRSEIMAQADIACYTAKHSGRGQVYLYQPRQKQLLR
QHLLSREDIENILSKHQLLLQATPTAPPKTPLVCFYQISYEINPSQNLIVSQSTFEEAALLYNLLAEVDGWVCEQLLVEQAEAINRK-G-LALAIPLSEV
ALLKENFRQSLLTLMHNTVLPPQSLYWMVDESTLLQYPFAIGNFLAKLQQLGCKLIVKEFGHNLNDFELLAEHTIDYLKFNSELISHIHINQMDEVLVSI
INGTAQRANIATLAGPAELPPTLNKLIAIGVDLADGETIGRSQPLSDVL-----------
>tr|C4SYY4|C4SYY4_YERIN Putative uncharacterized protein OS=Yersinia intermedia ATCC 29909 GN=yinte0001_10160 PE=4 SV=1
----------------------------------------------------------------------MEKEHIIESENRFRNAMEYSAIGMALVSPQ
GQWMQVNKALCKLLGYSQESLLTLT---FQQITHPDDLSA-DLKLLDDLYHGPSYSMEKRYIRSDGEIVWTLLVVSVVRDHQQQPLYFISQVEDINELKK
TEIVNRRTEITLDSIGEAVVCADQEMKITFMNPVAEKMTGWANTIALGQPVNIITNGVDGAEIDNPIEHCLNYSS-LNESMVLHHRDGQYYDIQESVAPL
KTLEGDIVGAVLVFQDVGESRAMMRKLSHSASHDNLTGLPNRANFENKLKAAIQISVELNQQHALAFLDLDYFKAVNDTAGHPAGDALLKELSQLMRQHL
RNSDCVARLGGDEFGLLMLNCTLPHAKAITQTLVSLINGHFYWEDKLYRIGASAGVTQISSSNNQRSEIMAQADIACYTAKHSGRGQVYLYQPRQKQLLR
QHLLSREDVENILNDNQLELQLTPTAPPRTPLVCFYQISFEVNRPQGLNVSQADFQEAALLYGLLPQIDNWICEQLLMTHAQAIKHK-G-LALAIPLSEV
ALLKEEFRQSLLTLVQQTVLPPQSLYWMVDESTLLQYPFAIGNFLAKLQQLGGKLIVKEFGHNLNDFELLADHTIDYIKFNSDLISHIHINQMDEVLVSI
INGTAQRANIATLAGPAELPLTLNKLITIGVDLADGQTISSPQPLSDLL-----------
>tr|A0A0B6H959|A0A0B6H959_YERRO Diguanylate cyclase domain protein OS=Yersinia rohdei GN=CH64_1429 PE=4 SV=1
----------------------------------------------------------------------MEKEHIIESENRFRNAMEYSAIGMALVSPE
GQWLQVNKALCKLLGYNQETLLTLN---FQQITHPDDLSA-DLKLLDDLYDGPSYSMEKRYIRSDGEVVWTLLVVSVVRDHEQQPLYFIAQVEDINDLKK
TEIINRRTEITLDSIGEAVVCTDQEMKITFMNPVAEKMTGWANTIALGQPIYIITNGVNGPELDNPIEYCLSYSS-LNASMVLHHRDGQYYDIQESAAPL
KTLEGDVVGAVLVFQDVSESRAMMRKLSHSASHDNLTGLPNRTNFENKLKVAIQQSIEQNQQHALAFLDLDYFKAINDTAGHPAGDALLKELSQLMRQHL
RNSDCVARLGGDEFGLLMLNCTLPHAKAITQSLVSRINGQFYWEDKLYRIGASAGVTHISSSNSQRSELMAQADIACYTAKHSGRGQVYLYQPRQKQLLR
QHLLSREDVAGILSNNQLVLQLTPTAPAKTPLVCFYQVSFEINRPHSMRVSQSAFEEAAALYNLQTPVDTWVCEQLLTEQAEAIHHQ-G-LMLAIPLSEA
ALLHEDFRQSLLCLLQTTPLSPQNLYWMVDESTLLQYPFAIGNFLAKLQQLGCKLIVKEFGHNLHDFELLAEHSIDYLKFNSELIAHIHINQMDEVLVSI
INGTAQRANIATLAGPAAMPATLSKLIAIGVDLVDGDTIGSTQPLSKVL-----------
>tr|C4UDQ5|C4UDQ5_YERAL Putative uncharacterized protein OS=Yersinia aldovae ATCC 35236 GN=yaldo0001_23600 PE=4 SV=1
----------------------------------------------------------------------MEKEHIIESENRFRNAMEYSAIGMALVSPE
GQWMQVNKALCKLLGYNQETLLTLN---FQQITHPDDLCA-DLKLLDDLYHGPSYSMEKRYIRSDGDVVWALLVVSVVRDHEQQPLYYIAQVEDINDLKR
TEIINRRTEITLDSIGEAVVCTDQDMNITFMNPVAEKMTGWANTIALGQPIEIVTNGVDGPEISNPIEHCLTFSS-LNASMVLHHRDGQYYDIQESVAPL
KTLEGHIVGAVLVFQDVGESRAMMRKLSHSALHDNLTGLPNRADFEIRLKAAIQKASDLDQQHALAFLDLDHFKTINDTAGHPAGDALLKELSQLMRQHL
RSSDCVARLGGDEFGLLMLNCTLPHAKAITQSLVSIINGHFYWEDKLYRIGASAGVTQISSSNNQRSEIMAQADIACYTAKRSGRGQVYLYQPQQKQLLR
QHLPGLEKIESIINNNQLSLLMAPTAPPKTPLVCFYQVSVEVTRSDDMFISQAAFEEAALLYGLLPRVDSWVCEQLLLTQAKAINRK-G-LALAIPLSEV
ALLKEEFRQSLLTRVQQTQLTPQSLYWIVDESTLLQYPLVVGNFLAKLQQLGCKLIIKEFGHNLNDFDLLTAHTIDYLKFNSELITNIHTNQMDEVLISI
INGTAQRASIGTIAGPADLPLTLTKLISLDVALADGETIGPAIPLRDLL-----------
>tr|A0A084YPP1|A0A084YPP1_9ENTR Diguanylate cyclase OS=Serratia grimesii GN=CR62_14935 PE=4 SV=1
----------------------------------------------------------------------VEKQHIVESEARFRNALEYSAIGMALVSPQ
GKWLQVNQALCKLLGYTPEALRRLT---FQEITHPDDLNA-DLEQLRDLLDGSSYTLEKRYIRSDGEHVWALLAVSMVRDAEGLPLYFISQVEDISELKR
TAAENHRTEITLDAIGEGVISTDDTMHITFMNPVAEQMCGWPLSLAVGMPLGVVTNGKDGMEVENPVQCCLQQLS-ADYALVLHSRDGRHFDIQQSVSPL
KTIGGNVMGAVMVLQDVTASRELMRKLSYSAAHDALTSLPNRTSFEKRLKAAIVGAGEKQRQHALVFLDLDRFKAVNDSAGHAAGDALLRDIAQLMQRHV
RDSDCLARLGGDEFGLILFDCASEQAKSLMQQLVNHISQPFYWEGKVYHVGASAGITRIDTGSGKSGELLAQADIACYTAKHRGRGQVYLYEARQKQMLR
QHLLTRQEVMSIIADGQLMLSVKAVAPPRTPLVCFYQLKLQIMPLDPRPLNSDAFIAAAQLYGLLPDVDDWISRQILERHAEEISAK-G-LTIALPLATD
SLLDTGFRHHLITRLNASPLQPQALLLVVDEAAVLEHDDICRPFIHQLQQLGCKLIVSGFGHSLNAFDELHGRRIDYIRIDERFITHVHCNQMDELMVSM
LNGAAHRVHAQTLAGPAHQQITLNTLQALGVDLADGDAVAREQPLTELL-----------
>tr|U2N615|U2N615_SERFO Sensory box/GGDEF family protein OS=Serratia fonticola AU-AP2C GN=L581_0550 PE=4 SV=1
----------------------------------------------------------------------VEKEHIVESETRFRNALEYSAIGMALVSPE
GKWLQVNQALCKLLRYPPETLRRLT---FQEITHPDDLNA-DLTQLQDLLDGSSYTMEKRYIRSDGESVWTLLAVSLVRDPQGQPLYFISQVEDINELKR
TEAENRSAEITLDAIGEGVISTDREMRITFMNPVAEQMCGWPLELALGMPIGVVTDGKDGPEIENPVKNCLQPLP-AEYALVLHSRDGRRFDVQESVSPL
KTIEGEVMGAVMVLQDVSASRELMKKLSYNASHDALTDLKNRTSFEKRLKGAIASAAESQQQHSLVFLDLDRFKAVNDSAGHAAGDALLREIGQLMQRQL
RNSDCLARLGGDEFGLILFDCSLEQAKQLMQKMIEQIGESFCWAGKIYHVGASAGITQIGATSGKSSELLAQADIACYTAKHHGRGQVYIYEARQKQQMR
QHLLTRQEVLDIIDNQQLLLRVRAASPPKTPQVCFYQLKLYVTPPDERLLAAESFLAAAQLYGLLPDVDRWLVSQVLERHAEALHRK-G-LAIALPLATD
SVLDIDFQSYLLELLAASVLPASALYLMVDETIVLDHPEDGGDFMRRLQQMGCKLIVNGFGRNLNAFNQLNGQTIDYIRIDERFITDVHCNQMDELMVSM
IHGAAQRINTQTLAGPAHQQVTLSALTAIGVDLVDGDTVALELPLSELL-----------
>tr|W0LAJ0|W0LAJ0_9ENTR Diguanylate cyclase OS=Serratia multitudinisentens RB-25 GN=Z042_04755 PE=4 SV=1
----------------------------------------------------------------------VEKNHIVESETRFRNALEYSAIGMALVSPE
GKWLQVNQALCKLLRYPPEILHRLT---FQEITHADDLHA-DLIQWQDLFDGSSYTMEKRYIRSDGESVWTLLAVSLVRDPSGQPLYFIAQVEDINELKR
TEAENRHTEITLDAIGEGVISTNSEMRVTFMNPIAEQMSGWSLELALGMPIGVITNGKEGPEVENPVQCCLQTLP-QDYALVLHSRDGRHFDVQASVSPL
KTLEGDVMGAVMVLQDVSASRELMKKLSYSASHDALTNLQNRTSFEKSLKNAIISAANHEQRHALVFLDLDRFKAVNDNAGHAAGDALLKEIGQLMQRQL
RNSDCLARLGGDEFGLLLLDCSLEHARMLMQQMVTQISEPFYWEGKIYHVGASAGITQISATSSKSTELLAQADIACYTAKHRGRGQVYIYEARQKQLMR
KHLLTREELTAIIDKRQLKLRVKAVSPPKTPLVCFYQLALQVIPPDEHALTSDAFFSAAQLYGLLPSIDRWMVHQILELHAQTIHQK-G-ISIALPLATD
SVLDSEFQHYLQEQLAASTLPCQAILLIVDETVILDHAENGGGFIRRLQQMGCKLIVNGFGHNLNVFDQLNGQKIDYIRIDERFVTNVHSNQMDELMVSM
INGAAHRIHAQTLAGPVHQQATLNALTAIGIDLVEGDFIAQEQPLVDLL-----------
>tr|S0AHV6|S0AHV6_SERPL Putative diguanylate cyclase YegE OS=Serratia plymuthica 4Rx13 GN=yegE PE=4 SV=1
----------------------------------------------------------------------EEKRHIVESETRFRNALEYSAIGMALVSPQ
GKWLQVNQALCKLLGYTPEALHRLT---FQEITHPDDLDA-DLTQVRDLLDGSSYTLEKRYIRSDGEHVWALLAVSLVRDPEGLPLYFISQVEDISELKR
TAAENHRAGITLDAIGEGVISTDDEMHITFMNPVAEQMCGWPLGLAIGMPIGVVTNGKDGEEVENPIQCCLQALS-TDYALVLHSRDGHHFDIQQSVSPL
KTVDGEVMGAVMVLQDVTASRELMRKLSYSASHDALTGLPNRTSFEKRLKAAIAGAGEKQ-QHALVFLDLDRFKAVNDSAGHAAGDALLRDIAQLMKHHL
RNSDCLARLGGDEFGLILFDCQREQAKSLTQQLVSHISQPFFWEGKIYHVGASAGITHIDAASGNSGELLAQADIACYTAKHRGRGQVYLYEARQKTMQR
QHVLTRQEVTTIIAEGQLVLNVTAVAPPKTPQVCFYQLKLQVMPLDDRSLTRDEFIAAAQLYDLLQELDRWIIGQILTQHAADISRK-G-LSVALPLATD
SLLDAQFQRDLLTTFGASPLQPEALLLMVDDTALLEHAAICKPFIHQLQQLGCKLIVNGFGHDLNAFDELHGQKIDYIRIDERFITNVHCNQMDELMVSM
LNSAAHRVQAQTLAGPAHQPITLNTLQAIGVDLVDGDTVALELPLSELL-----------
>tr|S5EN82|S5EN82_SERLI Diguanylate cyclase OS=Serratia liquefaciens ATCC 27592 GN=M495_18250 PE=4 SV=1
----------------------------------------------------------------------VEKQHIVESETRFRNALEYSAIGMALVSPQ
GKWLQVNQALCKLLDYTPEALRRLT---FQEITHPDDLNA-DLTQLHDLLDGSSYTLEKRYIRSDGEHVWALLAVSLVRDAEGLPLYFISQVEDISELKR
TAAENHRTEITLDAIGEAVISTDDEMHITFMNPVAEQMCGWPLSLAIGMPVGVVTNGKDGEEVENPIQCCLQQLS-ADYALVLHGRDGRCFDIQQSVSPL
KTIDGNVMGAVMVLQDVTASRELMQKLSYSASHDALTTLPNRTSFEKRLKAAIANATEKRLQHALVFLDLDRFKAVNDNAGHAAGDALLKDLSLLMQHHL
RNSDCLARLGGDEFGLILFDCTREQAQSLIQQLVNHISQPFFWEGKIYHVGASAGVTRIDADAGKSSELLAQADIACYTAKHRGRGQVYLYEARQKMILR
QHLLTRQEVTDIINDGQLLLHVRAVAPPKTPLVCFYQLKLQVRDQDGQALASDDFISAARLYDLTQEVDRWIIGQILTQRAPDIARK-G-LSIALPLTTD
SLLDASFQDDLLAALDASPLQPGALLLAVDDAVVLEHAGICRPFLQQLQQRGCKLIVNGFGHSLNAFDELHGQKIDYIRVDERFITNVHCNQMDELMVSM
LNGATHRVHAQTLAGPAHQQITLNTLQAIGIDLSDGDAIALEQSLTELL-----------
>tr|A0A086GBI7|A0A086GBI7_9ENTR Diguanylate cyclase OS=Serratia nematodiphila GN=JL05_10770 PE=4 SV=1
----------------------------------------------------------------------VEKQHIVESESRFRSALEYSAIGMALVSPE
GKWLQVNQALCKLLGYPPERLYRLT---FQEITHPDDLNA-DLTQLHELLDGSSYTMEKRYIRSDGQTVWALLAVSLVRDGEGRPLYFISQVEDISDLKR
SEAENNRAEITLDAIGEGVISTDSHQRITFMNPVAEQMCGWPLDLAIGMPVGVVTNGKDGPEIENLTQ----QWP-ADYALVLHSRDGRYFDVQQSVSPL
KTLDGETMGAVMVLQDVTASRELMKKLSYSASHDALTGLPNRTRFEKQLKAAIVAGGEPSSPHSLVFLDLDRFKAVNDTAGHAAGDALLRDIAQLMRHQL
RHSDCLARLGGDEFGLILYDCRLEQAKSLVQQVVNQISQPFYWEGKIYRVGASAGITRISAD-AKSSELLAQADIACYTAKHQGRGQVYLYETRQKQLLR
QHVLSLQEVQTIISEGQLRLLTHAVAPPATPLAAFHQVTLQVMAPDDRPLSHEAFIAAAQLYGLMPDIDRWTAAQLLVKYADDIKRK-G-LSLALPLAID
SLLSADFQRYLTETVRASSLPPQALLFSVDEAAILEHAAQCRAFLRELQQQGCRLIVNGFGHNINAFDELSDQKIDIIRIDERFITNVHCNQMDELMVSM
LNGAAHRIKAQTFAGPAHQPVTLQALRDIGVDLADGDQVALEQPLAVLL-----------
>tr|A0A087KYB3|A0A087KYB3_9ENTR Diguanylate cyclase OS=Serratia sp. Ag1 GN=IV04_15985 PE=4 SV=1
----------------------------------------------------------------------VEKKRIIESETRFRNALEYSAIGMALVSPE
GKWLQVNQALCKLLHYPPETLWHLT---FQEITHPDDLNA-DLTQLQELLAGSSYTMEKRFIRSDGESVWTLLAVSLVRDPHGQPLYFISQVEDINELKL
AEAENRLTKITLDAIGEGVISTDSEMCITFMNPVAEQMSGWSLELAQGMPISVITNGRNGPIVENPVQLCLQTLP-PDYALVLHSRDSRRFDIQISVSPL
KTVEGAVMGAVIVLLDVSASRELMKKLSYSASHDALTNLQNRTSFEKQLQDAIASVADNDQQHSLVFLDLDRFKAVNDTAGHAAGDALLKEISQLMQRQL
RNHDSLARLGGDEFGLILFDCPQEQAKTRMQQIVSLIGEPFYWESKLYHVGASAGITSINASSGKSTELLAQADLACYTAKHRGRGQVYTYEARQEPPIR
QHLLTRQQVVNIINQQQLQLYVKAVSPPNAPQICFYQLILRVTADTERPLTFKNFSAAAQLYGLLPEVDRWVVEQILDQHALSLTRL-G-VSIALPLTTD
SLLDRDFQHYLRQKLAATLLPHQALLLIIDEAIILDHTENAGEFSHQLQQMGCRLIVNGFGRSLNAFDLLNNQRLDYIRIDERFITNVHNNQMDELMVSL
LNNAAHRIDAKTLAGPVELPATLNTLATLGIDLVDGDIIAPAKSLAELL-----------
>tr|S3IPS7|S3IPS7_9ENTR PAS domain S-box protein OS=Cedecea davisae DSM 4568 GN=HMPREF0201_02962 PE=4 SV=1
----------------------------------------------------------------------IERKHITESETRFRNAMEYSAIGMALVSTE
GKWIQVNKSLCKFLGYSGEELGNLT---FQEITWPEDLNL-DLQHLSKLAAGNSYSMEKRYYTSAGNVVWAMLTVSVVRNTDGSPLYYIAQIEDINDLKH
TEWINKRNEITLDSIGEAVICTDVDMNVSFMNPIAEKLSGWAQEDAVGQHIAILTFGDNGPVMENIHSGDFSRTA-IEQDVVLHCRSGGSYDIHYTITPL
TTLDGQSIGSVLVIQDVTESRKMLKQLSYSASHDSLTHLANRVSFENHLKQLLQGALDHRQRHALVFIDLDRFKAVNDSAGHAAGDALLRELAAMMLGML
RTGDFLARLGGDEFGLLLPDCSTENARYISERIIRSINDHFMWDGRLHRIGASAGITHIDGDNAIASEVISQADIACYASKNSGRGQVTVYEPNRHYMEQ
GRTMPLDEQWRVIDDNPLLMVALAVAPPRIPETCFYLLSLRFWGSEGDVIDEPAFRAGLADPALHLALDRRVFNEFFVKFAAQVTMK-G-FGVALPLSGA
GLASNSFVDELLDRLRETRTPARLLHLTINSADLLENPEPVHANLKKLRAAGCRTILSHVGRDLELFNTLSHQLFDYVMIDPELILNVHCNLMDEMMITI
VHGHAQRLALQTIAGPADMPLVMDTLSGIGVDLIYGETIVQPQPLELLL-----------
>tr|J1GHX4|J1GHX4_9ENTR Diguanylate cyclase OS=Enterobacter sp. Ag1 GN=A936_04601 PE=4 SV=1
----------------------------------------------------------------------TERKHITESETRFRNAMEYSAIGMALVSTE
GKWLQVNKSLCKFLGYSSEELSDLT---FQQITWPEDLNL-DLQHLSKLEAGNSYSMEKRYYTSAGNVVWAMLTASVVRHTDGTPLYYIAQIEDINDLKH
TEWINKRNEITLDSIGEAVICTDVDMNVSFMNPIAEKLSGWAQEAAIGQHIAILTFGDNGPVMENIHSGDFSRSA-IEQDVVLHCRNGGSYDIHYTITPL
TTLDGQSIGSVLVIQDVTESRKMLKQLSYSASHDSLTHLANRVSFENHLKRLLQGAVEHRQRHALVFIDLDRFKAVNDSAGHAAGDALLRELAAMMLSML
RTGDFLARLGGDEFGLLLPDCSTENARYISERIIRSINDHFMWDGRLHRIGASAGITHIDGDNAIASEVLSQADIACYASKNNGRGQVTVYEPHRHYMEQ
GRTMPLDEQWQVIKDNPMLMIAMAIAPPRIPETCFYLLTLRFWGNEGDVINEPAFRSGLADPALHHALDRRVFSEFFDKYAAQVARK-G-FGVALPVSGA
GLVSDTFVNELLEQLSSRTMPARLLHLTIQSSDLLAEPQRAYASLKRLRKAGCRIVLSHVGRDLELFNTLSHHLFDYVMLDPDLILNVHCNLMDEMMVTI
VHGHAQRMALQTIAGPADMPLVMDTLSGIGIDLIYGETIAQPQPLELLL-----------
>tr|A0A059XU35|A0A059XU35_9ENTR Diguanylate cyclase OS=Kosakonia sacchari SP1 GN=C813_26405 PE=4 SV=1
----------------------------------------------------------------------AERKHITESEERFRNAMEYSAIGMALVSTE
GQWLQANKALCQFLGYSQDELRLMN---FQQLTWPEDLHK-DLELLDQLVRGPTYSLEKRYYTRNGDLVWGLLAVSVVRHADGTPLYFIAQIEDINDLKQ
TEWVNKRNDITLDSIGEAVLCTDVDMKVTFMNPVAEKMSGWPQEQAIGQPLTVLTFGDNGPAMENIHSGDMSRTA-IEQDVVLHCRTGGSFDIHYSVTPL
STLDGQNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLVTVQEFHQRHALVFIDLDRFKAVNDTAGHAAGDALLREISSLMLSML
RSTDILARLGGDEFGLLLPDCNVESARYISGRMVEAINDQFMWEGRLHRIGASAGITIIDETNYQASDVMSQADIACYASKNNGRGIVTVYEAQQGLMQH
ERMMSLDEQWHMIKDNHLLMIARGVASPRVPECNFWLLSLRLWTSEGEVMEEHAFRSGLTEPELIRALDRRVFHEFFRNHATAVAGK-G-LGVALPLSVV
GLASQSLVTELLQMLESGPLPGRLLHLIIHADALMREGNTINENLKRLRHAGCRIIFSHIGHDLEVFNHLTPHMADYLLLEPELVTNVHGNLMDEMMVTI
IQGHAQRLGVKSIAGPTHQPLMMDTLSGIGIDLIYGDIISQAQPLDLML-----------
>tr|A0A0D9H4S6|A0A0D9H4S6_ENTCL Diguanylate cyclase OS=Enterobacter cloacae GN=UO88_16580 PE=4 SV=1
----------------------------------------------------------------------AERKHITESEERFRNAMEYSAIGMALVGIE
GQWLQANKALCNFLGYSQSELQSLT---FQQLTWPEDLNT-DLEQLQQLIHGNTYSLEKRYYTRSGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKQ
TEWVNKRNEITLDSIGEAVLCTDIDMNITFMNPVAEKMSGWSQSEALGQPIKVLTFGENGPLMENIHSGDMSRTD-IEQDVVLNCRNGGSFDIHYSITPL
STLEGHTIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVQETHQRHALVFIDLDRFKAVNDTAGHAAGDALLRELSSLMLTML
RSSDVLARLGGDEFGLLLPDCNVESARYIAGRLIDAINNHFSWEGRLHRIGASAGITLIDDTNYQAAEVMSQADIACYASKNSGRGVVTVYEPQQERIHS
TRMMSLDEQWHMIKDNHLLMIARSVASPRIPESSFWLISLRLWTSQGEVLEEHAFRAGLAEPELLHALDRRIFSEFFRTYAAQVAAK-G-MGVALPLSEA
GLASVTLVDELLDLITRGPLPARLLHLAIAVDVLSNTDENVQQGLQKLRQAGCRVVLTRVGRDMNVFSQLSANTADYLLLDTDMVTNVHGNLMDEMMVTI
IQGHAQRLGIKTIAGPCHQSIMMDTLSGIGVDFIYGDTIGEAQPLDLLL-----------
>tr|V5CVI3|V5CVI3_ENTCL Diguanylate cyclase domain protein OS=Enterobacter cloacae S611 GN=EDP2_2786 PE=4 SV=1
----------------------------------------------------------------------TERKHIIESEARFRNAMEYSAIGMALVGTE
GQWLQANKALCQFLGYSQEELRLMT---FQQLTWPEDLAR-DMAQLQQLTRGASYSMEKRYYTRNGDLVWGLLAVSVVRHANGTPLYFIAQVEDINDLKQ
TEWVNKRNEITLDSIGEAVLCTDVEMKVTFMNPVAEKMSGWSQESAMGQPLKVLTFGDSGPVLENIHSGDMSRTD-IEQDVVLHCRAGGSFDIHYTITPL
STLDGQNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFEANLKRLLSTVQEYHQRHALVFIDLDRFKAVNDSAGHAAGDTLLREISTLMLSLL
RSTDILARLGGDEFGLLLPECNVESARYIAGRMIEAINDRFSWEGREHRIGASAGITIIDEYNHQASEVMSQADIACYASKHSGRGRVTVYEPKQGLMQH
ERMMSLEEQWRIIKENHLLMIARGVASPRVPECNFWLLSLRLWTSEGEVMEEHAFRAGLHEPELIRALDQRVFHEFFNKHAAAITAK-G-LGVALPLSVH
GLASSSLVDELLSMLESGPMPGRLLHLVIPADALVREGHTRLENLRRLRHAGCRIILSRVGHDLDVFEHITPHMADYLLLEPELVSNVHGNLMDEMMVTI
IQGHAQRLGLKSIAGPTHQPMMMDTLSGIGIDLIYGDTISQAHPLDLML-----------
>tr|A0A085G9Y1|A0A085G9Y1_9ENTR Putative diguanylate cyclase OS=Buttiauxella agrestis ATCC 33320 GN=GBAG_2637 PE=4 SV=1
----------------------------------------------------------------------EERKHITESEARFRNAMEYSAIGMALVSTD
GQWLQVNKSLSKFLGYTSEQLRSLT---FQQITHPEDLHA-DLHQLNMLVSGNSYSMEKRYYTSKGDVVWALLAVSIVRDIDGTPLYLIAQIEDINDLKH
TEWVNKRNEITLDSIGEAVICTDVDMNITFMNPIAEKLSGWPQQQAVGQHIAILTFGDNGPVMENIHSGDYSRAT-IEHDVVLHCRNGGSYDIHYSITPL
TTLDGQSIGSVLVIQDVTESRKMLKQLSYSASHDGLTHLANRVSFENHLKRLLQSAGENRQRHALVFIDLDRFKAVNDSAGHAAGDALLRELSSLMLSML
RTGDFLARLGGDEFGLLLPDCSSDNARHISERIIQSINDHFTWNGRLHRIGASAGITQIDADNRLASEVLSQADIACYASKNGGRGRVTVFESSQHDIRK
DGNITLAEQKSIINDNPILMIALGVAPPRIPETSFYLLSLRFWGNDGVVIDEKTFRTAVTDAELHCALDLRIFNEFFSKFSQSVTNK-G-FGVALALSSH
SLPCDKVVDELLALFARSALPTRLLHLMVHCEVLQNDDEKIERNLKRLHDSGCQLILSHVGRDLDIFKRVARQYFSYIIVDEELIQNVHCNLMDEMMVTI
IQGHAQRQTLQTIAGPADIPMVMDTLSGIGVDLIFGEAVTQPLPLEMLL-----------
>tr|A0A0B1XAR5|A0A0B1XAR5_9ENTR Diguanylate cyclase OS=Enterobacter sp. E20 GN=NI40_13370 PE=4 SV=1
----------------------------------------------------------------------AERKHITESEERFRNAMEYSAIGMALVSIE
GKWLQANKALCNFLGYSQTELQSLT---FQQLTWPEDLHT-DLEQLEQLVNGNTYTLEKRYYTRDGEVVWALLAVSVVRHADGSPLYFIAQIEDINDLKQ
TEWVNKRNEITLDSIGEAVLCTDINMNVTFMNPVAEKMSGWLQTEAIGQPIKVLTFGEKGPLMENIHSGDMSRSD-IDQDVVLNCRTGGNFDIHYSITPL
STLDGQNIGSVIVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLQTVRETRQRHALVFIDLDRFKAVNDTAGHAAGDALLRELSSLMLTML
RSSDVLARLGGDEFGLLLPDCNIESARYIAGRLIHTINDHFMWEGRLHRIGASAGITLIDENNHQASEVMSQADIACYASKNSGRGMVTVYEPQQERDHN
TRMMSLDEQWHMIKDNHLMMIARSVASPRIPESNFWLLSLRLWTSQGEVQEEHAFRSGLAEPELLHALDRRIFNEFFRASAAQVASK-G-MGVALPLSEA
GLASVTLVDELLDLLDKSPMPGRLLHLVISADVVCSPDKNLQRSLQKLRQAGCRVIFSQVGRDMNVFTHLTANMADYLMLDAEVVSNVYGNLMDEMMVTI
VQGHAQRLGMKTIAGPCNQPIMMDTLSGIGIDFIYGDTIAEPQPLDLLL-----------
>tr|A0A090V046|A0A090V046_ESCVU Putative diguanylate cyclase YegE OS=Escherichia vulneris NBRC 102420 GN=yegE PE=4 SV=1
----------------------------------------------------------------------AERKHITESEARFRNAMEYSAIGMALVGTD
GQWLQVNKALCSFLGYSQDELRLLT---FQQLTWPEDLNS-DLEQLESLVRGDSYSMEKRYYTRTGDIVWALLAVSLVRHPDGTPLYFISQVEDINDLKH
TEWVNKRNEITLDSIGEAVLCTDVDMNVTFMNPVAEKLSGWQQEHAIGQALNVLTFGDNGPALENIHSGDMSRSA-IEQDVVLHCRNGGTYDIHYSVTPL
STLEGHNIGFVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFENHLKRLLHTVQETHQRHALVYIDLDRFKAVNDTAGHAAGDALLRELSSLMLSML
RSTDILARLGGDEFGLLLPDCNIESARYISGRIIHAINDRFMWEGRLHRIGASAGITLIDESNCQASEVMSQADIACYASKNNGRGVVTVYEPQQDHMHH
NRLISLEEQSRMIRDNHLLLVARGVASPRVPECNFWLLSLRLWTSEGEAMEERAFRSGLADPELIRALDRRVIHEFFTNSAAGVVRK-G-VSVALPLSSA
GLASRTVINEIVEKLAQSRMPGRLLHFVIDADALMREESSIGDGLAKLRQAGCRLIISHIGRDLEIFNHLMPQMADYVLLEPELVNNVHGNLMDEMMVTI
VQGHAHRLGMKSIAGPTNQPMMMDTLSGIGIDYIFGDTISQAQPLDLML-----------
>tr|G9Z9W9|G9Z9W9_9ENTR PAS domain S-box protein OS=Yokenella regensburgei ATCC 43003 GN=HMPREF0880_04326 PE=4 SV=1
----------------------------------------------------------------------SERKHITESEERFRNAMEYSAIGMALVGTE
GQWLQANKALCRFLGYTQDELRALT---FQQLTWPEDLNS-DLEQLEQLVNGQSYSLEKRYYTRKGDVVWAMLTVSLVRHADGTPIYFIAQVEDINDLKH
TEWVNKRNEITLDSIGEAVLCTDVEMNVTFMNPVAEKMSGWSQVQALRQPLNVLTFGDAGPMMENIYSGDFSRSD-IEQDLVLHCRNGGSFDIHYSITPL
STLDGQNIGSVLVIQDVSESRKMLRQLTYSASHDALTQLANRVSFESHLKRLLHTVYENHQRHALVFIDLDRFKAVNDTAGHAAGDALLRELSALMLNML
RTSDVLARLGGDEFGLLLPDCNIESARYISGRIIKAINDHFLWEGQHHRIGASAGITLIDENNNLATEVMSQADIACYASKNNGRGMVTVYSPQQENLV-
PRMMSQEEKWHIIKDNHLVFMARSVASPRVPESHFWLLSLRLWTSEGDMVEERAFRQGLTESEQLRALDSRVLQLFFHDWSAKVAAK-G-ISVALSLSTA
GLARPALIDDLLNQLNQRQIPARLLHFIIDSEVMLSEETLVRQGIGRLREAGCKIILNHIGQDLEVFNQLTPEMADYVLLDPDTILNVHLNLMDEMLVTI
IQGHTHRLGMKTIAGPTNESLVMDTLSGIGIDMIYGDTIAQNQPLELVL-----------
>tr|D2ZEG0|D2ZEG0_9ENTR PAS domain S-box protein OS=Enterobacter cancerogenus ATCC 35316 GN=ENTCAN_06855 PE=4 SV=1
----------------------------------------------------------------------AERKHITESEERFRNAMEYSAIGMALVGID
GQWLQANKALCNFLGYSQTELQSMT---FQQLTWPEDLHS-DIEQLDQLVNGNNYSLEKRYYTRDGEVVWALLAVSVVRHADGTPLYFIAQIEDINDLKH
TEWVNKRNEITLDSIGEAVLCTDVDMNVTFMNPVAEKMSGWPQSEAIGQPINVLTFGEKGPLMENIHSGDMSRSD-IEQDVVLNCRNGGSFDIHYSITPL
STLDGQAIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRVSFETHLKRLIQTVQETRQRHALIFIDLDRFKAVNDTAGHAAGDALLRELSSLMLTML
RSSDVLARLGGDEFGLLLPDCNIESARYITGRLIHAINNHFMWEGRLHRIGASAGITLIDETNHQAAEVMSQADIACYASKNSGRGVVTVYEPQQERIHS
ARMMSLDEQWHMIKDNHLLMIARSVASPRIPESNFWLISLRLWTSQGEVQEEQAFRSGLAEPELLHALDRRIFSEFFRAYAAQVAAK-G-MGVALPLSQA
GLSSVTLVDELIELLEKGPFPGRLLHLIISAEVLRNTDENLQQGLQKLRHAGCRVVLSQVGRDMSLFSHLSANMADYLMLDPDVVSNVHGNLMDEMMVTI
IQGHAQRLGMKTLAGPCNQPIMMDTLSGIGIDFIYGDTIGEPQPLELLL-----------
>tr|A0A085G8A8|A0A085G8A8_9ENTR PAS/PAC domain-containing protein OS=Ewingella americana ATCC 33852 GN=GEAM_2583 PE=4 SV=1
----------------------------------------------------------------------VEKSHITQSENRFRNAMEYSAIGMALVSPQ
GKWLQVNKALCNLLGYEADYLKTLT---FQEITYGEDLGK-DLTLLQKLLDGQNYQMEKRYLRRDGEIVWALLAVSLVRDDEQNPVYLIAQIEDINELKH
TEITNKRSEITLNAINDAVISTDQQMNITFMNPVAEKMTGWSQAKAQGKPVDVVTIGPDGELINDLMAMYSSHTS-LEQSLILHGYHTGQFDVQLAISPM
RKLNAEPIGLVLVLQDVSKSRELMRQLSYSASHDLLTDLANRGCFEESLKGALTLTAEQQQQHSLAFIDLDHFKAVNDTAGHAAGDELLRQLSQLMQDHI
RNSDRLARLGGDEFALLLLDCPHEQGLQVVQSLVNKINEQFMWENQIYRIGASAGITRITDASLSSSEYMAQADVACYTAKNRGRGQVFAYEEQQKRLLS
HAIFRPEDIRRVLNEDQLSLNCRAASPPKTPLVCFYQLSLQFVQPVNGIQHAELLIEAARFYDMMPEIDRWMLRQVLEVHAKGINNK-G-ICVAIPLATE
SLLQESLRQELTRLLDNTLMPMGSVNLMIEPEVLLKHPH-LRQYIAELKQRGCKIVLRNIGKNLNEFNALPEGSVDYVQIDPTFMSQLHYNQMDEVLVTI
LHGNTHRLAAQTLAGPADLNETLEKLTSIGIDLVEGDTIAPLTSLNTLL-----------
>tr|A0A0E0Z1N1|A0A0E0Z1N1_9ENTR Uncharacterized protein OS=Edwardsiella piscicida C07-087 GN=ETAC_04505 PE=4 SV=1
----------------------------------------------------------------------RESQRLAENETRLRNVMEYSAIGTALIDLR
GRWIQFNPALCRMLGYEAAILQHLR---YRSLIYPPDRLS-DKRQLADLLAGDSYTLEKRYVHRSGRIIWTLLTVSLVRSPQAEALYFVAQMKEINDIKN
NERQKQRLDITLSAIGEAVISTDPQQIIRFMNPSAEKMTGWAPTRAIGRPLQIVQDSVSGAALSVLRPPN--DGG-ENDCLRLVSRSGQRYEVQSRVAEL
RHSDGVLMGYVVVFQDVSETRTLLRQLSYSALHDPLTGLPNRVSFEQALRCALRSAIESQRYHVLVFLDLDYFKAINDSAGHAAGDVLLQNIAQMMRSLL
RPQDILARLGGDEFAMILSDCDIAQGKRMVDQLIHEIAARFYWQGGLYRIGASAGLTLLWHRNALADEAINQADAACYMAKRSGRGQAFCHQGDRLPSGL
GVEPDAAQLSELLAAQRITLLLRAVCPRSAPQILFYLLDPEARRPDGSPFSASALATACLRYQRQQDVERWLFSQLLIRHARALSQQ-P-LALAVSLSTA
SLCQPTFVSWLCDTLRSSPLPARQLLLRLEESALIEHQAQTAPALSALHHCGCRLIAEGFERRLENIARLEHSPVEYLLASNELVAQAHANRMDEVMLSL
LHTQARSCGLQTIAGPAELPATLATLNLLGIDLLFGSSVHPTLTLPQLL-----------
>tr|M0QBC4|M0QBC4_EDWTA Uncharacterized protein OS=Edwardsiella tarda ATCC 15947 = NBRC 105688 GN=ET1_20_00590 PE=4 SV=1
----------------------------------------------------------------------RERQRLQENETRLRNVMEYSAIGTALIDLQ
GEWIQCNPALCQMLGYEASTLMSMP---YQQRVHPEDRQS-DKRQQAALLAGDSYTLEKRYLHRNGQAIWTLLTVSLVRNPRAEPLYFVMQVKEINDIKN
NQRQKQRLDTTLSAIGEAVISSDPQQIIRFMNPSAEKMTGWPQGEAIGQPLTVIQESNSGKARSVLRAGA--GDD-ENEPLSLHSREGRRYEVQSRVAEL
RHGDGILMGYVVVFQDVSETRTLLRQLSYSALHDPLTGLPNRVSFEQALRRALRGAIEYHQRHVLVFLDLDYFKSINDNAGHAAGDRLLQDLAQLMRSLL
RPQDTLARLGGDEFALILCDCELSQGKLMVDQLIHEIAAPFPWQGQQYHIGASAGLTQLQHDNALADETINQADAACYQAKHRGRGRAFCHSPQRSPHSA
AREPTADQLSALLADARFTLLLRAVCPRDTPQIDFYLLDLEACQDDGTPYTSQAFTTACLRHQRQQEVEHWLLSQVLEQHAECLSQQ-P-QALAVAISTA
SLGQPAFVRWLCDALERSPLPADRLWLRLEESALIEQQTQTAPALAALRRYGCRLIAEGFERHLENIARLEHCQIDYLIASSGLVAQAHANRMDEMMLSL
LHTQAHSYGIQTIAGPAELPATLATLNMLGIDLLFGSCLHPTITLTQQL-----------
>tr|G9YBC1|G9YBC1_HAFAL PAS domain S-box protein OS=Hafnia alvei ATCC 51873 GN=HMPREF0454_03900 PE=4 SV=1
----------------------------------------------------------------------SERDHIEESETRFRNVIEFSAIGTALVGLD
GRWIQVNPALCQMLGYPADVLTDMT---FQDITHRDDLET-DLRQLNALVDGNSYSMEKRYLRSSGESIWTLLSVSLIRDPQGEPLYFVSQIKDISEIKN
NERYKQQLDITLTSIGDAVISTDSHKHVTFMNPVAEKMTGWTQLEALGLPINIVYDGVDGDTVHPLRMDEVSAKR-TEDRLILKNLQGAHFDVQSRVSEL
TDIHRNLMGYVLVFQDVSESRELLRKLSYSALHDPLTGLPNRVSFEQALKRALRQAVEEKRTHALVFLDLDRFKAVNDSAGHAAGDALLQKISQSMLSHT
RPPDMLARLGGDEFAFILLDCETHQAKEHITRIINEINDLFEWEGKLHRVGASAGMTVINSGNAIAADLMNQADIACYTAKHSGRGKLMCYEPKNKLHIY
EKLLSGEDIDAILAEDRIHILVQGIAPPKTPRIAFYNLELMPYQNNGVNILPELFLESCFQNHRREDVDRWLLRKVLNHTSQALKYK-G-VSVALPLASS
SLCNPQFTAQLVDMLQNSALPTSRLLIRIPESAVNEDYAQSQPALNALSELGCRLIVEDFGRNLSAIERLESVNIEYVMITPTLITNVHCNQMDEVLVSI
IHGNAWRHGAQTIAGPADIQATLLTLDSIKIDLAFGNMIQEVKPLTAVL-----------
>tr|A0A085GQ80|A0A085GQ80_HAFAL Sensory box/GGDEF family protein OS=Hafnia alvei ATCC 13337 GN=GHAL_3950 PE=4 SV=1
----------------------------------------------------------------------LERDHIEESETRFRNVIEFSAIGTALVALD
GRWIQVNPALCQMLGYPARTLTDMT---FQDITHRDDLES-DLSQLSALVEGSSYSMEKRYLHSSGTSIWTLLSVSLIRDPQGEPLYFVSQIKDISEIKN
NERYKQQLDITLTSIGDAVISTDSLMRVTFMNPVAEKMTGWTQEEALGLPINIVYDGIDGDSVYPLRTDENSTRR-AEDRLILKNLQGAHFDVQSRVSEL
TSINGNLMGYVLVFQDVSESRELLRKLSYSALHDPLTGLPNRVSFEQALKRALRQAVEEERTHALIFLDLDRFKAVNDSAGHAAGDALLQKISQLMHSNI
RTQDILARLGGDEFAFILIDCEADKAKEIITRVINQINDIFEWEGKLHRVGASAGMTLINIGNALAVDLMNQADIACYTAKHSGRGKLMSYEPKHKQHIY
GKLLGAEEIDDILTQNRINIQAQGIAPPKTPQIAFYNLELIPHSTAGINILPELFQESCFQNHRREEVDRWMLREVLENQAQALKSK-G-ISIAIPVATS
SLCNPTFTTQMFEMIQASQLPPTRLLIRIPESALNEDYAHAQPALNTLTELGCRLIVEDFGRNLSVTERLQSVKIEYVMITPTLITNVHCNQMDEVLVSI
IHGNAWRHGAQTIAGPADIQASLLTLDSIKIDLTFGNMIQEVKPLSSVL-----------
>tr|W0WJH6|W0WJH6_PSEAI Sensor protein OS=Pseudomonas aeruginosa MH38 GN=P38_4045 PE=4 SV=1
----------------------------------------------------------------------REQHQVAIGEAQFRGAMEFSAIGMALVSLE
GRLFKVNEALCRMLGYSAERLGELS---FQEITYVDDLEL-DLDLVRDLLAGNSYQMEKRYLRQDGETFWARISVSLVRDEEGVAQYFVTQVEDIDSRKR
AELERERAEVTLYSIGDAVLTTDAGGRVTFMNPVAEAMTGWTLQDAIGAPHLVFLDSDTGEALESPVRRCLQVFY-LEDGATLISRKGEQHDIQNCAAPV
RTRDGEIIGTVLVFQNVTKARAMQRELSYHASHDALTGLFNRTKFEEELQRALANAQERATQHALCFIDLDRFKVVNDSAGHAAGDMLLRELSRILADRT
RASDTLARLGGDEFGLLLFDCDLAEAEQVASKLIEQICSRFPWEGRLYDVGASIGITALTATSRSTSELMSQADVACYAAKHAGRNRVSVYQFGHEEVEQ
HRILLASGLREALENDRFQLQAQEIVPVGP--DRHYELLLRLYDPDGQMTPPGAFIPAAERFNLMASIDRWVINEALINFGARIAAVEG-LSIGINLSGN
SLNDPLFLPYLLDRIEHSPLRPERLYFELTETALMNQLSVASRIVAKLRDLGCKVALDDFGSGLSSFNYLKNFVVDVIKIDGSFVRNLDKSPVDQAIVDS
INQIAHRLGAVTVAEFVESREILDHLARLGVDFAQGYAVGRPQPFATVL-----------
>tr|A0A0D7FDN3|A0A0D7FDN3_9PSED Diguanylate cyclase OS=Pseudomonas oryzihabitans GN=UM91_09130 PE=4 SV=1
----------------------------------------------------------------------HHNQRLARNEARFRHALSAAPYGMALLSVE
GRLSQVNAALEAMLGYPRHSLDGRS---LKELIADGEEPL------------EEGEQTRRLLHRDGQGLWMQLALSPDHDDGDLLTGYLLQARDIDAQRR
AEATNARTTVTLASIADAVLTTDMDGRILFLNPVAEQLTGWSLADARGRPHEVFHDSQSDEVLPSPVTRCLRITS-LDEGAVLLSRQGDRHEVQDSAAPV
RTVDGRIIGAVLVFQNVTHARNLQRELSYNASHDALTGLYNRLKFEQELDAAWQQAQAGTVQHALCFIDLDRFKVVNDSAGHAAGDLLLRELGTLLRDSL
RGSDAVARIGGDEFALLLRDCDLVQAEAVAEKLIASIGARFNWQSRIYDVGASAGIVAITAETRSPAELMSQADVACYTAKHAGRNRAALYRAGSEDVEQ
HRILMASGLREALEQHRFELHAQTIVPTRS--AQHVELLLRLRDVQGQLISPATFIPAAERFGLMSSIDRWVVRQVLVELVPWLQERPG-LHVGINLSGN
SLSDPDFLPELLELIAASPLDPQRLLFELTETAVINKLSVASALISQVRERGCRIALDDFGAGLSSFAYLKHFRVDYVKIDGSFIRSLDQDPLDRAIVES
INQVAHHLGAETIAEFVESQATFELLGTIGVDYAQGYALGKPLPLQEWP-----------
>tr|V2JCG4|V2JCG4_9BURK Diguanylate cyclase OS=Cupriavidus sp. HPC(L) GN=B551_0214955 PE=4 SV=1
----------------------------------------------------------------------RDRSELRGSERRFRQAMHHSAIGMALVSVD
GRWQQVNRAICELFGYSATELSRIP---FQDITHPDDLAA-DLAQLERLVAGDSYRMEKRYRRKDGNFIWALLAVSLVRDEAGAPLHFIAQVEDIHEHKL
AQQRLEATEITLRSIGDAVICTDASLRITFINPIAEQLTGWTMAEADGRPLTVFVDETSGQPIACPVAKCLQPVY-LEDGAVLISRHGERHDVQDSAAPV
LTPRGDVIGAVLVFQDITAARALQRKLAHSAMHDALTGLPNRIWFEQRLREACESAREFDQHHALCFIDLDRFKIVNDTAGHAAGDVLLRELGHVIRSQV
RPDDLLARLGGDEFALLLRNCSVDQGERVCLKVIDAIRARFPWEGRVYDVGASVGITAIDREAPPLGELMSRADVACYAAKAAGRNRVSVYRRDESDARH
HRLQVAAGIHSALEANRFRLFAQEIRALAPSAASHIEILVRMVDEQGSLVMPGAFIPAAERYDLMGHVDRWVIQHVLRDFGARLLAVPG-LSVSINLSAN
SLGEPFLLPFLHAELSNSVLPASRIRLEITETALINNMAAANRLVADMRKAGCTMALDDFGAGLSSFAYLKQFPVDYLKIDGSFIRHLASSAVDREIVSS
INDIGHRLGILTVAESVEDEATLDVLREIGVDYAQGYAIGRPMPLEDYL-----------
>tr|U3QDV8|U3QDV8_RALPI Diguanylate cyclase OS=Ralstonia pickettii DTP0602 GN=N234_03510 PE=4 SV=1
----------------------------------------------------------------------HGAASLRRSDKRFRQAMEHSAIGMALVGRD
GRWQTVNRALTELLGYSADELCELS---FQQITHPDDLDD-DLRAARSLLAGESYRREKRYRHKDGEYRWALLAVSVVRDEHGEPQHFITQVEDIHTRKL
AQQELERTEITLRSIGDAVICTDAAMRVTFMNPIAEQLTGWTMASATGLPLQVFVDESTGNPIPSPVEACLRPAY-LQDGAVLQSLTGERHDVQDSAAPV
LTARGEVLGAVLVFQDITTARALQRELARSAMHDALTGLPNRTWFEKRLREACDAARLQGHRAALCFIDLDRFKIVNDTAGHGAGDVLLRELGYLIRNHV
RPDDVLARLGGDEFALLLKDCTVDQAEQVCQDVIDAIRGRFPWEGRVYDVGASIGIAAIDLDVPPVSELMSRADVACYAAKAAGRSRVSVYRRGESDARH
HRLEIAAGIHSALEANRFRLFAQEIRALQPGSPRHIEILVRMVDEHGELIMPGAFIPAAERYDLMGHIDRWVIHHVLRGYGERLRAVPG-LSVSINLSAN
SLGEPFLLPFLHAELEASALPASRIRLEITETALINNMSAANRLVLEMRRAGCTVSLDDFGSGLSSFAYLKQFPVDYLKIDGSFIRQLADNAVDREIVSS
INDIGHRLGVLTVAEWVEDERTLDALRAIGVDYAQGYAIGRPEPLDAFL-----------
>tr|Q46XV6|Q46XV6_CUPPJ PAS:GGDEF OS=Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) GN=Reut_A2666 PE=4 SV=1
----------------------------------------------------------------------AGRANLHSSDQRFRLAMEHSAIGMALTGLD
GRWQTVNRSLSELLGYSAAELRQQR---FQDITHPDDLDA-DLGQMQRLLAGESYRLEKRFLHQDGEYRWALLAVSLVRDQQGHPLHFIAQIEDIHTRKL
AQQQFEQTEITLQSIGDAVICTDAGMRVTFMNPIAEQLTGWTMASASGLPLRVFVDEVTGLPIPSPVEACLQPAY-LQEGAVLQSLTGERHDVQDSAAPV
LTATGTVLGAVLVFQDITTARAMQRELAHSAMHDALTGLPNRTWFEKRLREACDAARTQGHHGALCFIDLDRFKIVNDTAGHGAGDILLRELGYLIRNHV
RPDDLLARLGGDEFGLLLKDCTVDQAETIGHGVIDAIRSRFPWDGRVYDVGASIGIAAIDQDVPPVGELMSRADVACYAAKAAGRSRVSVYRRDESDARH
HRLEIAAGIHTALEGNHFRLFAQEIRALQHPRERHVEILVRMVDEHGEMVMPGAFIPAAERYDLMGHVDRWVIRNVLREYGERLCAVPG-LSVSINLSAN
SLGEPFLLPFLHAELEHSALPANRIRLEITETALINNMAAANRVVTEMRRAGCTVALDDFGSGLSSFAYLKQFPVDYLKIDGSFIRNLADNIVDREIVSS
INDIGHRLGVKTVAEWVEDERTLNALRAIGVDYAQGYAIGRPVPLDAYL-----------
>tr|A0A0C4Y5I4|A0A0C4Y5I4_9BURK Cupriavidus basilensis strain 4G11 chromosome main, complete sequence OS=Cupriavidus basilensis GN=RR42_m0823 PE=4 SV=1
----------------------------------------------------------------------RDRSELRGSERRFRQAMEHSAIGMALVGLD
GRWLQVNHAICDLFGYDAAELAELP---FPAITHPDDLAP-DLRQVERLLAGESYRIEKRFRHKDGHYRWTLLAVSLVHDENGKPLHFISQVEDIDERKT
ALEKLEATEITLRSIGDAVICTDASMGVTFMNPIAEQLTGWTMQAAAGQPLSIFVDEHTNAPIPSPVEQCLLPVY-LQDGAVLQSLTGDRHDVQDSAAPV
RTATGEVIGAVLVFQDITGARALQRELAHSASHDALTGLPNRIWFEKRLREACDAARMQQQHHALCFIDLDRFKIVNDTAGHAAGDVLLRELGHVIRYHV
RPHDLLARLGGDEFALLLMDCTVDHAERVCQKIIDAIRGRFPWEGRVYDVGASIGITAIDHETPPMGELMSRADVACYAAKAAGRSRVSVYRRDESDAQH
HQLQVAAGIHSALDANRFRLFAQEIHALQRNQERHIEILVRMVDEQGKLVMPGAFIPAAERYDLMGHVDRWVIHHVLHEFGERLSAVPR-LTVAINLSAN
SLGEPFLLPFLHAELHESVLPASRIQLEITETALINNMAAANRLVTEMRSAGCTVALDDFGAGLSSFSYLKQFPVDYLKIDGSFIRHLAGNAVDREIVSS
INDIGHRLGMLTVAESVEDEETLQALRSLGVDYAQGYVIGRPMPLELFL-----------
>tr|L2EK95|L2EK95_9BURK Diguanylate cyclase OS=Cupriavidus sp. HMR-1 GN=D769_07223 PE=4 SV=1
----------------------------------------------------------------------NGRAELRSSERRFRQALEHSAIGMALVGLD
GKWQLVNRAMVDLLGYSAEELRDLP---FQVMTHPEDLAA-DLSQLDRLLAGDAYRLEKRYRHKQGHYLWALLAVSLVRDEHGEPRHFIAQIEDIHTRKL
AQEQLEATRITLRSIGDAVICTDRVMRVTFMNPIAEQLTGWSLDAAMGQPLQVFVDEITGLTIPSPVEQCLEPAY-LQEGAVLQSLTGERHDVQDSAAPV
LTNDGGVLGAVLVFQDITSSRAMQRELAHSATHDALTGLPNRAWFEKRLREACEQARLHGHRTALCFIDLDRFKIVNDTAGHGAGDVLLRELGYVIRHHV
RPDDLLARLGGDEFALLLKDCSIDHAEQVCQKVINAIRERFPWEGRVYDVGASIGIAAIDADAPPVSELMSRADVACYAAKAAGRNRVSVYRRDESDARH
HRLEVAAGIHSALEANRFRLYVQEIQPLQP--ARHVEVLVRMVDEQGTLIMPGAFIPAAERYDLMGHVDRWVIRNVLHQFGERLARVPD-LVVSINLSAN
SLGEPFLLPFLHSTLEDSMLPAARLVLEITETALIHNMTAASRLLKEMRHAGCTVALDDFGSGLSSFAYLKQFPVDYLKIDGSFIRNLADNVVDREIVSS
INDIGHRLGVRTVAEWVEDETTLRVLRAIGVDYAQGYAIGRPMPIEIFL-----------
>tr|D8KBI9|D8KBI9_NITWC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Nitrosococcus watsoni (strain C-113) GN=Nwat_2894 PE=4 SV=1
----------------------------------------------------------------------RAEAEIIQSQARYRSLYHDTPAMLHSIDRQ
GRLLSVSAYWLTIMGYERDEVIGRR---STDFMTDASR---------------RYAIEV---------------V-------------------------
-------ETVTLESIGDGVITTDANGRINYLNPIAEAMTGWLLAAAQDKALEVFINESTCEPAADPLAPCLTIVR-STHSTVLINRHGTEYSIEISAAPI
RDSNRQVLGAVLVFHDVSEQRRLQREIAHQAQHDALTGLVNRREFEQRLQRVIEAAQTQNSEHALCYLDLDQFKVVNDTCGHTAGDSLLQQLATLFEKNI
RRHDTLARLGGDEFGLLLEHCPLDSALRIVNTLRQTVEDRFCWNGQYFRIGVSIGLVPINSANSSVASVLRAADSACYVAKDSGRNRIHIYREHDVDLAR
HGMQWVARIQQALEEDRFQLYAQPIVPFKK--GIHCELLLRLVENDGKISPPGAFMPAAERYNLAVAIDRWVVSQALRWLATHPALLDRIMLCTINLSGR
SIGDRFFHAYVLRQFDDTGLSAKKICFEITETAAVANLADATRFMQALKKRGCRFSLDDFGSGLSSFAYLKALPVDFLKIDGLFVKDIVHDPIDLAMVRS
INEIGHLLGKKTVAEYVENNAILDKLRNLGIDYGQGYGLGRPQPLSALL-----------
>tr|E3CZV3|E3CZV3_9BACT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Aminomonas paucivorans DSM 12260 GN=Apau_0451 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----TNRRFCELMGASPEDLLSRP---VEELFHPDDLITTPLVYEEVLR-GGVVTRERRLLRPWGAPLRVEMRSKLLSD--GT---VMSLFRDLSEREE
AQARLQEQQALFANAPFELWVRDAKGRMLLQNPLARKGQGNLLGEAVEE-------HRGLSEETRRLWRETNRKDVIQREMEIR--EGREICLYKVIAPI
W-REGKVRGILGVSLDVTEEKVQAQQIERMAFYDALTDLPNLRLFNAHLEERLAAVRDGGEGGALLFLDLDDFKLVNDSLGHALGDQFLVEVAARIRTVL
GPDRLAARLGGDEFLVLSAPGEGRDVDILANELLGLFEAPFEQGGVRQFLSATLGVACFPEDGLYPEALLAQADMALHKAKREGKRSFRFYDAALQEEVV
KSRELENHLRDALEAGELEVFFQPQVGVSSGRVEALEALARWHSPTLGQISPGRFIPVAERSGLIVPLGALVLREACRFAAGLEAQGLPSLRVAVNVSAR
QLLQEDFAETTLRVLEETGLAPSLLEVEITETTLMESFDRVSETLRHLREKGVRVALDDFGMGYSSLTYLRRLPLDTLKIDRSFIVDSRR-EGNRVITRA
MVRLGHDLGLEVVAEGVETEEHRAFADEAECDVIQGYWYSRPLPPEEVRAFLSR------
>tr|B3PCW8|B3PCW8_CELJU Sensory box/GGDEF domain/EAL domain protein OS=Cellvibrio japonicus (strain Ueda107) GN=CJA_1331 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------HTLYLDASFLPIKNKQGKLERVLVQLQDLSRELY
ARAALQESEAFITNSSEAIWCYDMQPRLVEANRVLLNMLGVTLDDVLGQPLSE--SGSTNYLFDL---DTFIANGQMVDDITRQDERGKKFYFQISCTGI
I-EDGYLRRIWGTTKDVTTRKRYEDKLRHQSLHDSLTGLPNREKLYQDMASCFEQRTA-EQISALMLIDLDRFKEINDTLGHNVGDRLLQMIGPRLAAEM
AEPGTVARLGGDEFAVFLPRIRSHQAVVFGHRILDALAQEYDLEVFCTQMSASIGIAIAPYQAQDHHALMRYADIAMYYAKSQML-GLSIYSPDYDPHSP
KRLAMMSELGRAIRENQLCLYYQPKVVLDECRCYGFEALIRWIHPELGFVPPDDFIPIAEFTSLIHPLTAWVLENSIEQCRHWQLQGLN-LSVAVNLSAR
NLMDENIPKLVERLLNKYQLPAARLELEITESSIMSDPNRALRILQHLHELGVHLSIDDFGTGYSSLAYLKRLPVQTLKIDNSFVRNMLGDLQDELIVNS
TIHLAHNLGLTVVAEGVENEELMKRLHDMGCDEVQGYFIGRPMTVNNADQWLVE------
>tr|A0A099JY73|A0A099JY73_9MICO Uncharacterized protein OS=Cryobacterium roopkundense GN=GY21_00785 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---LTANDRWLALSGLTIQQSLGDG--WA-QAMHPEDADRVAAAWSAAVVARTSYQGTLRFRTPEGRVSWVQVSTAPIHGPDATVTGHLATVTDITELRR
AEEAAAAARAAFASSPLGTAIVSLDGQVLEANRRLFDLAGPT--GFVGQGHEFMPPGADSSARL-----SLTDGASTRQDRRMRRGDE-ETWVKVSIAEI
-NEGEQAGEFLYQLEDITARRLAEARVEHLAFHDPLTNLPNRLLLLDRLNQALLQAGKHGLGVAVLFIDLDRFKFVNDSLGHHAGDAVLTEVGTRLRRHA
RSTDTVSRIGGDEFVVICPGVGSRDVRKIADTLQAAIAKSILVGDQVASVDASIGIAFGLGH-DDAESLLRNADQAMYLAKGRGRARYEVFDDDLRGRIE
RRLDTELALRTAVERGEIETWFQPIVDLQQQTVVATEALARWRRPDRGLVAPGEFIAIAEEVGLIKGIGTTVLGQACRAAASL--EG--HLAVSVNVSPR
QFVQDDFGAVVKLALAETGLPPDQLWLELTESAVLEAIDSAARTFQELRSLGVRLAIDDFGTGYSSFAHLKSFTVDLLKIDLTFIRDLECSDHDRAIVEG
ILRLADSLKLDVVAEGIETIGQRDLLTEMGCRYGQGYLFSKPGPAVDFGDMLSS------
>tr|E0MRE3|E0MRE3_9RHOB Putative eal/ggdef/pas/pac-domain-containing signaling protein OS=Ahrensia sp. R2A130 GN=R2A130_2987 PE=4 SV=1
------------------------------------------SLLVFLLFLAVAGFIVYSVFLR--RTLDELDP-GRVIPERVQKAFDTLSEGVIILDER
ERVLLANSAFEAMYGSAGGLETGTRIPWRKAGGYPWH-----S----AIKEGEKREEQLSLRTASGQVLNLNVNATVFTGDKNETIGAIVTFANMTDNKQ
SADQLAKAVSLLEETQRTVLMLDVHG-LAGIKASFGPAVS---DALIRCAADSARSGLTNNAPV-------GRYGSLVGEIKATFSDRTA--------DI
ASGANAVTLCVGIANDINGGDSDDQQALADRQSQRIESCKEQTQFLENATRSIVRAQDEEKSLAILQLGIASWDYFEEALGEDLSQLLLRFAKRQVDIAL
REQDTLLEE-TGQMLIELPDVEADDVSWIVKRILDRFNEPIEVGQKTVYLSCRVGAALYPQDGQDTLTLSRNAAIAMRRAQLDDTEELRFYSADMVQTSS
RTLEIETGIREALQANQFELVFQPIVNATDTSLTAAETLLRCTSERLRGVRIDQIIDIAERSSLIADIDMWVVNNSIHQMQLWDQAGVHLAKLSVNLSAN
QITKPDFMDMVVERIASCHFSPSRIQIEVTETAKMGGLEVAAQQLKRLQDMGVHIALDDFGTGQASLTYVQRLHPDVIKIDRSFIDGLNKNHANATMVAA
VTAMAHSLGITIVAEGVETEAELEFLRHISCDYIQGYFISKPIPADAMRDWIMT------
>tr|V5E2Q4|V5E2Q4_9GAMM Putative eal/ggdef/pas/pac-domain-containing signaling protein OS=Methyloglobulus morosus KoM1 GN=MGMO_9c00370 PE=4 SV=1
------------------------------------------STFKMSGFILLIGFFVYLVFML--RTLKLLDP-SAVIPERVNTAFDTLTEGIIVLDDH
EQIVLANKSVTEKLSLPLTSLMGVKLQWKSGHPFPWQ-----K----VLASGSYIGTQLKLTSSDNKVFKFVINASPIQGANAETHGVLITLDDITELEE
RNTALQTMVLRLEESQASCFMADIDH-FKAVNDNYGHAKG---DEVIKLLAELLHSNTRKVDLV-------ARYGGLPGTIRLRLKDEST--------NR
FESGPRVTASFGVASLVEENKTVDDQIETDKFSAAVTGLPNQVLFYDRINQVIERGNRYDQLAAVLVIDIGMLSQTNTTLGRSAGDKLLVEMAERLKATF
RKYDSVSRFGGDEFAVLLTELGTEAVTWIVNRLLESLSEPIDIDGNSVYAMSHVGVSLYPSDANTVDNLINNAMIAKKYSKQMHSTNYQFFDEHMQQLSI
KHVNLDKELRRAIQNEEWVLLYQPKMDIKKRSIIGVEALIRWQHPTRGLLSPFEFIDFAEQRGMIVAIGDWVIKKACLQIKEWEKSMLSDCRVAVNLSAV
QLRQDDFVTKIFQTLADTGIPPRLLELEVTESTLMNNFDVALASLKRLNSRGIAITIDDFGTGYSSLGYLKNLPINTLKIDRIFIKDICNDNNDKQIVKA
LISMAHSMGMIVVAEGVEEQNQYDLLAQYACDEIQGYLLSKPIPAIELIDMLRK------
>tr|S6AFR8|S6AFR8_9PROT Uncharacterized protein OS=Sulfuricella denitrificans skB26 GN=SCD_n00900 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---IKADDSFLGAFGVSRDESIGSD---VGNMLDAKA---LTKIVAAARNTSTTARISLNIDHRDGRRVPLEVV-ACIDDLEGEVLRCFALLM--TQNHE
EFQHRRFLASAIEVSSQAIVIANNLREIVYVNPAFTQITGYDSGEVLGKDLCEPALE-TD----ELAIAMLRQGRPVQTELLSRDKDGTSYWVDLSVVPV
KDDHGAIGHFIATAHDITQRKQVEAEMCRLAQEDHLTGLSNRRASEELLEREWNRARRGKGTFAIAIADIDRFKLVNDQYGHQVGDLVLQHVAKTMEQAL
RSGDWVGRWGGEEFLICFHGVDNGAL-IAAERLRKLIKSPLKTAQGEQPLTMSIGVSQYQPEFDDIDTMLAQSDSLLYEAKQTGRDKVLCYGCSDT-RME
SVIWEGSQVQRALHEGRLIPAYQAIVDLKNRTIVADEALARIRAKDNTLVEAKNFIEAAEALHLVASVDQSISSSAIARCSHAVLSAIAGHKHFINLSQQ
FLANGEQVGAFLARAQEYCETAKPVVIEITERQG-GDIMLLKKNLKPLTDFGFKLALDDFGSGYSSFRYLAELPVDYLKIEGWMVGRITSDKRTRLLVET
LVGTAQKLSITSIAECVENEETAQMLYDMGVDWAQGYHFAHPMPAVEMTAAH--------
>tr|A6QBP9|A6QBP9_SULNB Uncharacterized protein OS=Sulfurovum sp. (strain NBC37-1) GN=SUN_1965 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------SA-VGETI---------------------SQQF-TPTTLVFSITLILFLALYIVKREKR
KFGKIDVMQKAFEVCKDAVLILSRKQEILYANKPMRKLLKLDEDYQKTVLDNS--IKVDM----GKEWRTLSRKRTMQTKLLTHEKNEIPVNFYIDTAEE
EDDGS-SRWSIVSIHDLTEEKQ----KEEAEYCHRLTNLPNQIKALQDINVLNARLHLSDAKIALVLIDIDNLSVLRSIIGYEQTNAILKKFAEYLKNLA
KEYHFTPYHFYNNFLLTVTDVDDDEIKALTEKIQEELCTFYKIGENRLYLSASMGISIYP-DSGPMIRLFDNAYRALAKAEKAGYGRTELYLLEKKKYDY
DELTLYNDMHAGLEREQFEVYYQPIVDSKSKEIASAEALIRWRHPKYGMIPPDVFIPIMEKTGFIVELGKFVLNEVLRQQKRWELFKFQQIEVSINLSLL
ELESGNFVNNVLDRLKHHQVNPELIKYEITEGLAMKNEERSSQQFIELRKLGVAIVLDDFGTGYTSFAYLKRFPATTLKIDKELIDCIITNEENQHIVKS
IINLGHSLGMKVVIEGIENKNMVDLLENYGCDYMQGYYFSRPLPVFEFQKML--------
>tr|I2K741|I2K741_9PROT Uncharacterized protein OS=Sulfurovum sp. AR GN=SULAR_06738 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------------------QDIIAQIT---------------------REEY-ATMAILL----SILFVFYTLSRQQK
KLNNLKVFQKAFDLSDDAVLILSPQNKVIYASNAMVRLLDLKSDFLLKTFIST--AQIKV----KKEWAGLNQHRIPHITLKISADDEIPVNVYLDTIVM
EMPKG-VLCDVISIQDLSKAKE----RSAADFKHPLTHLPNQLQVYNDLPAFFSKAHLEKNKLALMLMSLDNLSRLRSIIGDEQANDILKKFATYLETLT
KNANVSVYHFDNHFLMTVTNLHSDEAKIFIENIQKKLATFYKMDGVHLHLTASAGIAIYP-DSGNIRLLLDHAYKALAQAEQEGDNNITVFLPEKFTAAY
DELRLHSDMPGALSRGEFEVYYQPIVRSKDQEVVAAEALIRWKHPQYGMIPPDVFISLMEKTGFIVKLGQFILDEVLKQQKRWELFNFKSIEVSINVSMI
EINTGEFVQHVEKKLAEHQLDPECIKFEITEGIAMLNEAQTVKYFLALKKLGVGISLDDFGTGYTSFGYLKKFPADIVKIDKSLVDYILTNEEDQRIVKA
IIELAHTLGMKIVVEGIENKQMVDMITSYGCDYLQGYHFSKPLPVFEFQKLI--------
>tr|Q21N07|Q21N07_SACD2 GGDEF domain OS=Saccharophagus degradans (strain 2-40 / ATCC 43961 / DSM 17024) GN=Sde_0660 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------GLQNLTLGVVRPDKELVWLKLNVAIINSDTNIPHGVLISFVNITAETE
AHTALEKASLALDGASIGIWDWYIDAEMIW-DDQMYRLYGMEPRQYISVREAW-EHVAHPDD-NQRVLDLLKTKKDTISEFRVLLPDKSIRHLRAYARAV
LDEDGLVQRVVGMNWDVTKEVEAEERLAHIAFTDELTSLPNRLAFSKKLKNTMKLAEKYHGKVAMLIVDLDHFKDINDSYGHPVGDSLICEVVTRLKEVL
VGDEYLARIGGDEFALILDNVRSDAALHYSRRIQKIMAEPIYLMGPVVNARVSMGVALFPDDGEDAVALIKAADLAMHQAKKSGRNTVLPYKQEYSSSLE
KKIFLEEELRSAIRDEELMLYYQPIIDLSTEKIVGCEALLRWIDRAGKFVSPVDFIPVAEESGLIYELGNWINATAFKQLKLWQTLHTDMKYISVNVSPH
QLQNADFVKDIQRLLDIHNVDPRHIQLEITEGTFLQESLNTQSQLRILGEMGFRLAIDDFGTGYSSLAYLKRFAVDVIKIDRSFVMDLEDDPADRDIVKA
IIAMTTSLGFDTLVEGVETREQSLIVGALGCGYGQGYLYGKPTFADDYAE----------
>tr|R5EAG6|R5EAG6_9CLOT GGDEF domain-containing protein OS=Clostridium sp. CAG:590 GN=BN724_01060 PE=4 SV=1
-----------------------------------------------------------------------------QAKELACRIMDLSEQAMIVIDRN
YSVVYANAKAKAIFG---EQMTNAT---CYLAMEGEGTP-----CETCP--FRESEEKDRIVRQFDRTVQVKITF---LDSEGQPVM-IYTILDSDELLL
AREQLRLSGTVVSQLHTMVFEYNKAQNTYSVSPLFKEK--FGIDEIHNINFLLYLIYEPDCDIYN-MLF-TSREDDFRETCRLRMNNGQLVWYRICIQFI
RNDKGQIVRVIGTLKDVDDATRSYETLRYRSEFDMLTNIPNVNRFYVDAGRAI--MEDESNHYAIISFDIDKFKLINDLFGMSTGDEVLKHIANVLRDRV
PENGWYCRVHSDMFLICIPYSNRDIIKKVEKIRKEIYKNSF-----SFDVNTTYGIYLVEDVTIPINLMCDRATLAARTVKGNAMNFCAFYDEQYRAEII
KNTEIERDMNAAISHKQFLMYLQPKYNLVTGKICGAEVLARWKHPVKGLIQPNDFIPLFERNGFILRLDEYMWEEACKTLARWRDEGRKLVPLSVNISRY
HIQHNDLVGAWKRLIKKYRIPTSYLTLEITETFFY-DSKDLYEVLEQLQAMGFLLEVDDFGAGYSSLNMIRQIPVDTIKIDKDFLDKKLSTEKGKIVISH
TIAMAKDLKLGVIAEGVETKEHVDFLKSSSCDVAQGFFFAKPMPVKEFEHIY--------
>tr|Q7MRY3|Q7MRY3_WOLSU Wolinella succinogenes, complete genome; segment 3/7 OS=Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 
-----------------------------------------------------------------------------TPEEILKAILDESRVMIHVIDPR
FEILYANRAMRQEFS---D-IIGRP---CFEAIHNRSIP-----CGHCMQPFSKSTQHEHINLNNGRIYLLHSHS---GQSDGRKVK-FQIAIDVTEQRL
SPQMLEVIKAT----IEGLFIFDRNQKCVYANHIALNLFGYTLEEVHSKSILFRFSQNRDQPPYE-VLG-IK-------------NDGSLF--PIMIRGK
AIELGEEKFRLSAVIDITKMREKENELFQIKRYDSLTSLPNRR-FLEDLLKSLHTSHQNGCYRALLFIGVDRFKLFNDSKGHSFGDQLLYEIAQRLKAAT
ASMGALARFGGDEFTLLLEDGSKEEIRRSARQSAKLLQAPFVLLGQSISITASIGIISFKETARSPRTLIKYATSAMHHAKKKGCNTICFFEPLLQRRFE
ERLELQEDLRDAIDKEQLELFYQKQMRVNEAECMGAEALLRWKHPARGFISPLEFIPLAEEGGYIHLLGEWVLKHALQKLQKWQKDPQKHWRLSINISAK
EFEREDFISNVQKNFNQTPCPPHRLCIELTEGILIQDPEKSIQKILALASMGILFSIDDFGTGYSSLQYLKKLPIQELKIDRCFIQNILEDEQDQILVDT
MIGIGKKFNLNVVAEGVETQEQLKKLQSMGCELFQGFLFSKPSPVLSAE-----------
>tr|Q6AIJ1|Q6AIJ1_DESPS Chromosome OS=Desulfotalea psychrophila (strain LSv54 / DSM 12343) GN=DP3110 PE=4 SV=1
---------------------------------------------------------------------------LQQEKDQYKRIVDVGIHGFWEWNLV
DESLFISAKAKKMIGYEEIDFNSSIEAWW-DLVHPEDYV---QVVETSLSPDPSYDIQYRILHRDGHYCWLQSRALGVW-QDGELLQIIGSHTDVSQRRK
REHTLQ---VLYQVSMANYLNQGL-GRYEAVHEA---IAS----------------YSQVNNFYVALWRHVMRRGSSQIDVEMKTCIGVVPASWLGVPLI
QDDRDDVYLLEAVAEQVIERDQVYERLLHQANHDNLTGLVNRQYFLDWGEKLFNPTDGERRRHALLMLDLNRFKQINDSLGHNVGDRVLVEVVVKIRSQL
RELDLLARLGGDEFAIILEDIVSAKVVKLVASIIKSVEAGVEIDGRTILTGVSVGLVMDICQYDNIHDVLRYADIAMYEAKYNSPKYFRVFNQKLHSRVR
KTIEIEQILTNEFDPEELVVQYQPIIDLEQRRLAGFEALVRWQNPRLGYLFPDQFLPVAEEIGIISKIDEAVLELTCANIAQWRQQTTAHIRVSVNLSQN
ELVDLNLAQRIIKTVERYGLKPSDLAIEVTESALMSNVRFGKRILMDLRESGIGIHIDDFGTGYSSFGHLADLPFDVLKVDKSFLLQAHESVQRMTVLEA
LVRMSKSLEIPVVVEGVEEREHLDLVCALGCRYGQGYHFAKPIDRDKVVDF---------
>tr|A0A0C3J4B4|A0A0C3J4B4_9RHOO Thauera sp. SWB20 PO78.SWB_20._Contig33, whole genome shotgun sequence OS=Thauera sp. SWB20 GN=PO78_4331 PE=4 SV=1
--------------------------------------------------------------------------------RQLQQAGHLARLGAWEDRRG
QGLVYWSDVCYDMHGVPRGSALPRD--YLNTFVVPEHRDRMRTQLQHCLRARSDWELEIQILRTDGRKLWVRSRGEAVLDDDGRITAMRGVMQDIDAQKR
QEESIREREALLEAASLGRWDWDLHTGLITGDAFWSTLNHLPVQASLGQARELV--GSHDIRFNQELLRHIDHDGPFDVTWRLQTAHGR--SRWLRSMGR
YDLHGRAMRMLGVCLDVTTQQEQKHSLQQLAHFDALTGLANRIELAARLHEALVQARQSQQLLGVVYLDLDGFKPINDRLGHDAGDRLLVLVAKRLQHAL
RADDCVARFGGDEFVLLLSQIHTVQCENLLQRLMASISRPYTLDGEAVQVTASIGYTLYPEDDCDADTLIRHADHAMYQVKQSGRNRIQAFDSSQERSQR
AQQIQGLRIREGLEGGEFTLYVQPKVDTRHQRVVGVEVLSRWLHPERGVLSPQDFLPLIEGTELEVPFGQWALRHAMGCIEQLIAQGLQ-LQVAVNISAR
HLQQPGFAQWVTELLQAHDVPPHWLDLEITESAALYDLQHVAQVLAQLRAQRISVTLDDFGTGYSSLTYLRGLPLDSLKIDRSFVRDMLSDPGDCAIVHG
VVSLAQAFGYSVIAEGVESADQCTALELMGCHIAQGFHFAPPMPLAQLPAWLST------
>tr|K0IAQ4|K0IAQ4_9BURK Diguanylate cyclase/phosphodiesterase OS=Acidovorax sp. KKS102 GN=C380_13100 PE=4 SV=1
----------------------------------------------------------------------VVEQVLRDSEIEQRSLIDNLMTGLVIHDAT
GAVVRCNAEASNLLGLSFEQMTGKQLAWSF--LNEEGQTMPVSDYPAVVATREPVNVVGIVRSKDADICWVLCRADPWFTPVGALDKIVVTFVDITMRRK
LTSQLQDREALFDNSMDAVLLTSPDGTVLAVNRAACRLFGLSEAQIIARGRAGLADP-TDPR-LHELLGRREQMGQAAGLLTMVRGDGSRFTAEISSSIY
GDSEGRQ-YSSMIVRDMTERLRSQAQLAEVAHFDMLTHLPNRVLLADRLQQAMAHCVRRQKSLAVAFLDLDGFKDINDRYGHAAGDEFLVAIAKRLRLAL
RDGDTLARIGGDEFVAVMSDLSTHDCEPLLLRLLQVAAEPLQVGGNSLQVSASIGVTIYPQDGSSSEQLIRHADQAMYLAKQAGKNRFHLFDVASDAA--
IRIKRESQIAAAIAQHQLVLYYQPQVNMQTGEVVGMEALVRWLHPERGLLAPGQFLPVIEDHDLAIAIGERVLDLALSQMAQWLAAGLH-LPVSVNVFSR
QLQQDDFVHKLRQALAAHPVPSSALELEIVETSALQDMAQVSGLMHACAELGVRFALDDFGTGYSSLTYLKKLPAELLKIDQSFVRDMLDDRDDLAIVQG
VVGLSKAFNRKVIAEGVDTVAHGRKLLAMGCVLGQGYGIARPMPAQQVPGWLDQ------
>tr|D5V2S6|D5V2S6_ARCNC Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Arcobacter nitrofigilis (strain ATCC 33309 / DSM 7299 / LMG 760
----------------------------------------------------------------------------------------------------
--------SKKELSNISPSQLSP--------LYQPDGRLKEKEIIQKCSKNG-FIRFEWLHIDLNKKEFWVEVTLRKS--TLKNEEIFIGSWRDISQIKE
KEKNILKKEDIIDSDSSIVSKTNTKGIITYVNNKFCEISGYEEKELLGKNHNIIRNPANSKEFFKKMWGTLENKNIFRGVISNKKKDGSIYYVNSTIIPV
LDSNNEIKEYIGIRNDVTSLFEKDEIITKQ-FTDNVTGLPNRQKLVEDSKNLLFP--------KLAMININYFRDINDTYGIDVGDFVLKEFSNKLSTLS
DLNINIYRISGDLFGILAFGNYTESLKILCLDFLEVKINPIKYDGHALNLSFSIGISSG------REWLLVEAEMALQQAKAENK--VLVMENKNNDALK
KKVELTNKIKYALKNDNLLIYGQKIINNIT-GETKYEVLMRL-KVDDKILSPYFFLEHAKKARLYHEMTRKMIKLACEYFKDKENSFSINLTI----Q-D
ITNEETVEYLTNVLLETKT--NKRIILEIVESEQINQFEKVTSFIKKMKHLGARIAIDDFGTGYSNFEYIIKLNVDILKIDGSLIRNIHKDKNIFIAVST
IVNFAKQLGLEIVAEFVDSQEVLETIKSLNIDCAQGYFLHEPEHL---------------
>tr|A0A0C7NYN1|A0A0C7NYN1_9THEM Defluviitoga tunisiensis genome assembly DTL3 OS=Defluviitoga tunisiensis GN=DTL3_1044 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------NFKRVTGFGKDEIPR--------N--------LDELIKLLREED-FHRF---QHNLNNYDYGSEWILRVS--LKEKREGFD-NFELVGKKKR
MDRDIIILRDVFDNSQQAIVITDKNNKVVTINKAFSDMMGYSLEEVVGKDPHFWSSNMHDKTFYQRMWYDLKTKGFWNGRIINKKKNGEIIFTYSNIFEI
KGYNNELIGYIAINSDITTNIKREEELTRVHKYDFQTWLPNKEFLLEKMRDVISKTTVNDAEYVLIVIKINKMHELPIVYDFEKTNIIIKEITERVTKIA
ANDFFVSRIADDEFALFGSLNSLN-IEEISNTLIKTLAEPLQIFGEKAFIKARIGISTYPHNSNDPEQLINQARTALNVSSKND---INFYSPDLSNLIK
YENLIEEEIYQALQNNKLVLFFQPQIETRF-ELIGAEALVRLQKSDGTILSPMDFLEVAKKKGLMTEIDRFVLESTTKIAKELNSS-KNRLKVFFNVSKS
FFEDEDFLNFIEIVLDKYGIDPSCLGVELTEEIFIDDFYSAQKKINALKKMGLQIALDDFGTGFSSLSYLNKLRIDKIKIDKSFVDDLLKSESSKRLVSS
IISMSHILGLEVIAEGVETEEQLSFLQSKGCYEIQGYYFSKPLPL---------------
>tr|A9BH42|A9BH42_PETMO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Petrotoga mobilis (strain DSM 10674 / SJ95) GN=Pmob_0538 PE=4 S
----------------------------------------------------------------------------------------------------
--------NLKQITGIGKNELPQ--------N--------LNELLGLIKEED-VQKI---IDKVNSSEYEAEWTLKVS--LKSNREGFN-TFDLIGKKKR
RGKDVLVLREVIDNSPQAIVITDKNNKVVRVNKAFLKMTGYTLDEVIGKDPHFWASNMHDKSFYEQMWQELKSKGFWSGRIIDRKKNGEVIFLYSNFFEI
KGYNNEVIGYMAINTDITNRVKKEEEITRVLKHDSLTGLPNSKNLLERIEEILQKNTQE-NKLALLIVEIEELHELIDFYGLETMNHVIKDVAKKIIEIV
DKKYFVSVISKHEFALLGSFEDVE-LEKFAANLLNNLSKPFQIFGERIFLKMKIGVSNYPVDSTNPEDLINQAKIALKDSEKKT---INFYSPELSKIFG
FEKKVEDEINLALENKGLLMYFQPQIDTNM-NIIGAEALIRLQKENGSILSPNEFLGIAKKNALMDRIDQFVLEETIKSSGVINESLNKNVRIFFNVSKS
FFERENFLYNIESMLHKYNLNPSYLGIELTEDLFIEDFYSAQKKIKALKEIGLKIALDDFGTGFSSLSYLNKLDIDKIKIDKSFIDNILHDETSQRLVSS
IISMSKSLGFEVIAEGVESEEQLLFLQEEGCYEVQGYYFSKPLPF---------------
>tr|R7L0R8|R7L0R8_9FIRM Signal transduction protein containing a membrane domain an EAL and a GGDEF domain protein OS=Ruminococcus sp. CAG:353 GN=BN622
------------------------------------------------------------------------------EKENLEHVIDHLNAMAVLWDTN
FSYVRVNNSLVRITGYSEEELRDPANLK--KILPADAFSELQAIV-------NNKDEEFFFKTKDGSVVCTVWNTSIVSRHNETQTIMISIGPDLTEVNK
MRNEIGESERKYALTEIGLLLREADNPKYYCSTRLRSMLGIVSEDGYIE-ESVLRKAFHDRSFASGMK-TIHDDVRVRTDFRAMSADGMYHWYNFRYKAV
SDS-GE-KCIGGAIIDITADKEKDLVIERMAYIDEVTQIYNRNKFMLMGNEILECTRDSSIDYWIIVFDIDNFHIINDTCGYANGNLLLRKFASALSVNV
SESGFAARIGGDNFALIVHTDGDQLPVRIIKSVQADIAD---IGGMGLNLTCSAGYCLMSDGGCEFAQVLDRAEFALSLSDG-TKNSILRFDNHAHDAII
QGNEIERELAKAIDNNELVLYYQPKIDLATGNVVGMEALIRWIKPDGTVVPPCNFIPVAEKSLLITKISHFVLYEACRQNKAWQDMGLAPITVSINLTAI
DFYQTNVTEVISTALRETGLAPQWLDVELTESLALKDIDHAVAQMKEIKELGVKLSMDDFGTGYSSLSYIQILPITVLKLDRSFIMYLEDDAISREIVSA
VIRIAKSKKIETIAEGIETIGQADILRESGCDQAQGYFFGKPMPADKFEQFLRE------
>tr|R6ZX05|R6ZX05_9FIRM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Ruminococcus sp. CAG:379 GN=BN633_01090 PE=4 SV=1
------------------------------------------------------------------------------NRRRIAYFIDNINTPALLWDNT
LEHIRINDSLRQVLGFAEGETLTQEQFP--ALFERQDWKQIRDIL-------RSRNAEFVIHTRSGQAVTMVWSTSGMQQ-TENTCLFMTIGVNVTETRQ
MQSEIAASEWRYSLSEIGILLTQGD-KYF-ISPELQRMLGLD--EASVS-FAAFRRLVHDTTFLRSVE-RLPQEDPIHSELRLRSADGEYHWYNYRYKAA
KLV-GADPIIGGSFINMDTEKEKDALIERLAYVDEVTGISNRNKLMLMGQETYACSLELGITYFVMVLDIDRFHLVNDAYGYECGNKTLQDFAHIMYKYL
SFGGFGARISADNFALILRDYGDELPVKTMERIQADLAQ---LGMTELALTCSAGYSRMPQDGESFAEVLEHAEFALSSAEH-RKGTVVGYNSSMHDTIV
GESELEKQLSDAIDNGELRLYYQPKIALTNGRIIGVEALIRWIRPDGTVVQPGSFVPIAETSQLIRKISDYVLSEACEQNRIWQRMGLPNIIMSINLTSA
DFYQTNVCEAVYEALARTGLEAQWLEIELTESLALKDLDMALEQMHQLRAMGVRLAMDDFGTGYSSLSYLQVLPITLLKLDRSFVVNLEQDEIAREIVAA
VIRIAKSKHIETIAEGIEHPEQARLLRIAGCDNAQGYLYGKPMPPKEIEEFMRR------
>tr|W7UZZ5|W7UZZ5_RUMFL Uncharacterized protein OS=Ruminococcus flavefaciens 007c GN=RF007C_12025 PE=4 SV=1
------------------------------------------------------------------------------DEKDITKIIEDLNTEMIIWSDN
FSYVFINKKLRDLLGISADRSDKKEAVW--TAFGINSSDNLMKIA-------GSNSYESSFRNPHGTLVSIAWSTSPVKK-YRKQSVYLSTGFNLTELKK
MRVNLASANDFFHASEIGLLMSTDR-KLFRASPELMRMLGLK--TGSIN-INEFRSLIHDRGAIRSKD--------IRNEIRIKSADGSYRWFSYRFKSI
PGT-GNTPLFGGAIIDVTQEHEKDILIERLAYIDEVTDIANRNKLVGTGQEIYDSCKVLNYSFWIIVLDIDRFHIINDTIGYSNGNYVLKNFAHILYKFV
TPGGLAARISGDNFALLLRDYGDEMPTRTVKSIQEEFSK---LAVDELNLSCSAGYSKMPEDGNSFLDVMEHAEFALKSSDG-TQGSVCGYEPSMHDSII
GNTELEKSLALAIDNNELQLFYQPKIDLASGRIMGVEALIRWIKPDGTIIKPDVFVPIAESSHLIGRISEFVLNEGCRQNKLWQKMGFPPIVMSINFASS
DFYQNDLKEKVFEALARSGLDPQWLEVELTETLALSDIDFAVDQMNKLRDLGVKLAMDDFGTGYSSLSYLQILPITLLKLDRSFITDIEHDNIAYEIVSA
VIRIAKSKKIETIAEGIENNVQESILRMAGCDYAQGFLYGKPMPPEKIQEFFDI------
>tr|E3GJT5|E3GJT5_EUBLK GGDEF domain-containing protein OS=Eubacterium limosum (strain KIST612) GN=ELI_1058 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------AEHMIHPEDSKRFLEFFDATLESGGSVIGEFRKLWVDGDFHWASLTVFPAVSGGGEDEILLCFIMDIGYKKQ
LEDIEKENELVIEQTNTLVFEWIIGTSQRYYAPKFSEIFMGS---YDGRDIKVVHPKDID-VLKQKMSME--AISNGQVEIRLCNKEGRYIWCKVVFNVL
YNEDGSIKRVVGTLNNIDESKRVHETLKYRAEFDLLTGIYNINTFYAQAERLVREH--PCQKFAVVRLDVNRFKFINDLYGREEGNRLLRFMATVISANM
GTMDAFGRMNSDVFCLCMSYASGDPLLVRIKKILKEINQF----SESYQVMPSCGICIVKDRDIQMSILCDWANLAQKTIKGSLIKQWAFYDKKLRAKQL
DERRIENEMDEALNKRQFKVYLQPKHNVQNGSVIGAEALVRWDHPERGFLTPDRFIPLFERNGFIIKLDEYVWEETCRIIKSWLDRGMVAVPVSVNVSRV
QVYNPNFYKKLLNIIRRYDIPKKFLEVELTESSFVENTVDLYRGMERLREEGIAFSMDDFGSGYSSLNMLKNVPVNTIKLDREFFNESVATQKGKTIIEH
TIGMINDLKLQVIAEGVETNEQAAFLNDCGCLAAQGYYYSRPMPVDEFEKQF--------
>tr|G1UUR0|G1UUR0_9DELT Uncharacterized protein OS=Desulfovibrio sp. 6_1_46AFAA GN=HMPREF1022_02333 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------AETLIHPEDREIFLHLLNQGESLKGYASGDVRKKCRDGQYRWARFTVFPLACAASGRPLHMICVQDVDEQKR
AVGLARENAAVLDHTNTLVFEWRDN-QPTYTSPHIPQLLAGD---YNGRWLFVLSPEDGG-IFKDCLNAL--EQGASSGTVRLRRRDGRFIWCRVTYTCL
TDPDL-GIRYIGTINDVDEVTRATQALHFRAEYDPLTGAYNMQTFFEKADLLIRQ---GDGPRHIVRFDVAGFKGINEMFGLEEGDRLLRAIAHLVREQI
DRLETFARLSGDVFVACLAGDRE-RVRHFVGWLSRQLREY----TQSYRVMLFFGICPVEKRRTPVHVLCDWAHLALKTVKGSDLTNYAFYDGELRARLL
DENNIKDQMHEALEKGQFVLYLQPKVEISSGRIVGAEALARWQHPTDGLILPGRFVPLFERNGFIVRFDEYIWEQTCKMLRLWLDKGYRPTPVSINVSRM
HFNDDRFCGKLLTLTDKYRLPRHLLELELTESAFFESERTLIRVMNDLQEQGFVFSMDDFGTGYSSLSTLRALPFNIVKLDRTFISDGTDNERGQIVARN
TVTLARQLKMKIIAEGVETVEQARFLLSIGCNYAQGYYYSRPVDPEEFEVLS--------
>tr|B8J4P9|B8J4P9_DESDA Diguanylate cyclase/phosphodiesterase OS=Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949) GN=Ddes_2284 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------LTRLVHPDDHNALLRFWDDLEKNGPFSTLDVRRKCHDLSYRWTRITAFPVRQ-PGGHFVYLVCVQDVDDLKR
AATIVRENEAVVDHTRTLVFEWRNN-DLTYISPRIGELLAGN---YDGRIPFVLYSGDSA-AFDTCLSRL--ALGIRSGTLRLRRRDGQFIWCKVTYTCL
ADDSP-GERYIGTINDVDAATRTEQALRLRAEHDPLTGAYNTQTFFEKVEALLREY--PTEPYAVLRFDVAGFKAINEAFSLEEGNRLLRAIARLIRQRI
NQCEAYARLTADVFAVCITGDIN-RIKNFIHSLSRRLEHY----SDTFRVKLFFGVCQVENRRTPAHVLCDWAYLAQKTIKGSDLANYAFYDNALRQRLH
DESYITDQMYRALEQKQFKLYLQPKVELSSGRIVGAEALVRWQHPHDGLILPGRFVPLFERNGFIVRLDEYIWDLTCQNLRMWLDKGYKPMPVSVNMSRL
HFNDGALTKKLVQLVDKYRLPRHLLELELTESAFFKNEKALIHIMCELQAEGFIFSMDDFGTGYSSLSTLRALPFNIVKLDRAFISDGTDNERGQIVARN
TIALAKDLHMQIVAEGVETLDQARFLLSCGCNCAQGFYYSQPLDQDAFEVLS--------
>tr|G1UUQ9|G1UUQ9_9DELT Uncharacterized protein (Fragment) OS=Desulfovibrio sp. 6_1_46AFAA GN=HMPREF1022_02332 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------ADTLIHPEDKAGFRQMFRRALATTRSTGAEYRKKCLDGSYRWVRIMVFPFD--ESGRERYLICFQDIDGYKH
LGASTRENVAITEQTRSLVFEWQEQ-TLTYVDAAIPRLLAGS---YDGRHLFVLFSEDRP-MFGNFLRAL--AAGDLSSTVRLRRRTGAFTWYVVSCTRI
DNTAT-GARYVGSLRDVDKAIHTAHSLRQQAEYDDLTGACTMPTFLGKTERLLRRY--PDTPRHIVRYDVTGFKSIDERFGQEEGRRLLRAISYLTKENL
SDREIFARLSGDIFLACLEGDHE-RVWKFMEWLRYGTAEY----AKAYRPELFFGVCRVDDPATPVREICERAYLALKSVKGRGMTDYAFYDDELRNRVL
DELFIKDQMYTALAEGQFVAYLQPKVEIFSGRIVGAEALARWRHPERGLIPPSRFVPFFERNGFIIQLDEYIWEEACKLLRSWLDKGYRPLPVSINVSRM
HFNDNGFCDKLRALTDKYRLPRHLLELELTESAFFENEKILQRTMHSLQENGFAFSMDDFGTGYSSLNTLRALPFNTVKLDRAFVSDSTGNQRGRIVARN
TIVLAKQLGMRIIAEGVETVEQALFLRNMGCDHAQGFYYSRPMDAREFEVFS--------
>tr|E4TF12|E4TF12_CALNY Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Calditerrivibrio nitroreducens (strain DSM 19672 / NBRC 101217 / Yu37-1) GN=Calni_1544 PE=4 SV=1
----------------------------------------------------------------------------AKTEKLTREITDSLKDFLIVLDEK
GKVIYYNPSVIKFFKDI-DNFTEK----LEYIISSSDQQI--SI----EVDGDSK---TFYLHKND-----------VI-ISGKKEATVILLLDITEKIT
LSEKFKLAYDIIRHNLSGIVVTDLNGIILDVNDAFTKITGYERNEVIGKKTSILKSGVHDDKFYTNIWENVSNRGIWEGEIWNKRKNNEIYPEYLSIFTI
KDENGKPKYFVGNFIEISEIKKYEEKLELLAYYNEVTKLPNKKFFIEKLRNFINDNK--GKDIAVCYLDLDGFKKFLDKYGLEVSNKIINQISNRIMPIL
KKSDILGHFDEDIFVIAT-IVDDKELEGYLEKIQFAIFRPITVDGVVWKFTCSIGVTIYPEDNDNPDELVRHAQQAVFQAKNRGKNRIVFFDTIMSKQLA
IKREKLAMIERGLKNKEFILYLQPKFNVEKKEVVGAEVLVRWVHPTHGLIPPSEFIPYISNSDIEVEFDKYIVSRAFECIDYLYSKGLK-VKLSINVSPN
ALLNEELIEFIRGTLTELKEKSSMIEIEIIESTSITDLNKASEILGEFNKIGFGISVDDFGTGYASLDYIKALPIDTVKIDRTFVVDMLSDPTNLNVTEV
VILLAKAFNKEIVAEGVENIETASALYKLGCNIFQGYLIAKPLPIEDFVDMYHK------
>tr|I3Y5K3|I3Y5K3_THIV6 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Thiocystis violascens (strain ATCC 17096 / DSM 198 / 6111) GN=Thivi_0201 PE=4 SV=1
--------------------------------------------------------------------EQTAEERLRESEVQLQAIFDNAFVGIMLLTGE
RLIARANDRVAQILGYRPTELIGLS---VRSLHLSEEREFGKRFFE-PLRNREQPHVEYQLRRRDGSPFYCSLSGRALDTPADLSKGAIWILDDIDELKR
IERALRESEALFESASEGMLII-RDSRFVSANQAAQRMLGLNLV--DGRSPAELSPPYQPDGQESAVKATLQQGAH-RFEWEHQRGDGGRFQVEVTLSRV
RLKDALLVSW----YDLSR----QHQIDYLSDHDQLTNLPNARLLRKRLIQTLNFAGFANARVAVLTLDLDGFKHVMDSHRHEVWEQVLKTLASRLVANS
PPATIVARISGDVFTLVLENAVDAWTTQQARRIQDCLCAPLPLNGGELCMTVCIGVALYPDDAHDAIELLRDAGSALHAAKRAGPGSLAFYTPEMTVSSA
NRLQLLQQLRQALQEDEFVLHYQPKIDLATATIIGGEALIRWRRPDGAMISPGDFIPLVETTDLVHPVGQWVLRTALHQMRIWSAASLPPQQVSINIAGP
QFASETLPDEIAAMLAETGIAPHLFQIELLESLLLDDPEKARRQLIAIRKLGVTVALDDFGTGYSSLAYLSGFPVDILKIDRSFVNNLAEDAGNLAIIRA
TIAMAHGLGIRVVAEGVETDAQIALLHRLGCDLVQGYRTGRPMPAGDFARLIAA------
>tr|M5PNG3|M5PNG3_DESAF GGDEF domain-containing protein,PAS domain-containing protein,EAL domain-containing protein OS=Desulfovibrio africanus PCS GN=P
-------------------------------------------------------------------------------EGSFRAILENTGTAAMIIAAD
MTIVHINTEFEKLVHLPRESVQGRM-SWM-DFCHPDDLERTMSYHRTRLAQKAPSAYETRLVDSAGEVRHVMVTASLIPGTS----LSIVSMRDVSELKD
ALRDLQKAYQLFERIPLATVLVDPQDRVMAVNNAFERLFGFGREESQGRSINIVPPELADEATG--ISR-QTQDGQLVAESKRRTADGRTLDVSIIGTPV
YVGQRQ-EAVFGIYQDVTEQNRTRQQLVYQANHDHLTGLSNRRRLLTRVGDAIRRGKHVDRDFAVLFLDLNRFKVVNDSLGHLFGDAMLIIIARMLQDSL
GDNGVVARLGGDDFGVLVEHQQVDFVRSFVRRVQERLRTPFQVMGRQVTTSASVGVVFGRAEYARAEDYLRDASLAMQRAKVEANENCQVFDGRMHDHAM
RRMLLESSLRTALDNQEFVMHYQPIVELVSGEKRGYEALIRWNRKGEGIVPPDEFIPLAEETGLIVPMGYWALERACLDFGRLCAPNSHELSLSVNISGK
QFRDPEIYSRVKSILRQTGMPAERLRLEITESMLMQDPENVSRILSRLKNLGIKISVDDFGTGYSSLSYLSRFPIDVLKIDKAFVAPLEQSSPTVRLVQT
IITLGNSLGLEVVAEGVESSKHVSRLTSLGCNLGQGYLFARPASLAD-------------
>tr|D3NU01|D3NU01_AZOS1 Sensory box/GGDEF/EAL domain protein OS=Azospirillum sp. (strain B510) GN=AZL_012420 PE=4 SV=1
----------------------------------------------------------------------------------------DGGMALVYLDRD
LVCRHADPHFAAVLDRSPADLIGHR---LTAIAHPVSAA-VEAAIAAPMRNAAPLDCPT--VGRDGRRFILSGSVVAHRDAAATTVGYLGSFHRTGDPDR
IAEFVRDSATLLDAAVDGIIVSDRTGVIRSINSACCRLFGYDDGELVGRNMTVLMPPDHYVGYMRTDRAKIIGIGR---ETLGQRKDGTVFPIHLSVGEA
R--LGNDVTFVGIIRDISERLAAERRASYLARHDPLTGVLTRTAFLEECETLLATCRPDGDQFALFSLDVDQFSDVNEAFGFHVGDAALKAMVSRVTEVL
PPNTIICRIAADEFAALSR-VTDDHARRLAGVLHDRLTASIYADRHWVRLRLSVGAAVRDESAGTLEDLNAKAKLALQAVQHNGGNAVCFYTPEMAAAAT
RRMMLTMHLTHAIERNELRLVYQPIVDR-NGRVRSAEALLRWDHPALGPVSPGEFIPVAEESGLIVPLTDWVLSTAIAQMARWEAAGVLPDRVFLNISGQ
QFLRGNLMLRLDELLGEHPSLRRHLGLEITEQAAVRDLKVAVRTLGELADLGIQAAIDDFGSGYSSLSYVQQLPVAKLKIDRAFVIDVPENPKSNALVRA
AVGMAHGLGLTTVAEGVETEEQRDFLVSVGCDMMQGFLFGRPMTPDALADLVRGQAAP--
>tr|A0A024QN76|A0A024QN76_MYCNE PAS/PAC sensor-containing diguanylate cyclase OS=Mycobacterium neoaurum GN=BN1047_01854 PE=4 SV=1
-------------------------------------------------------------------------DDLRQARDLFAGVLQASEQAIIGADPS
GRITVFNNGAERLLGWTRAEMLGRS--LLSIHRLPEVRSRRFEVLTRLVTPDRAEVREWTYVRRDGAFVRVSLAVSQMTDPDGSCTGYIAVATDITEQDA
AKRALAESELAFDTAPIGMFLFDVAGLITRCNQSMANLLGRRPNEVPGMHVTDLCDRELT-FFPEGLLRDLEVGDRFEAEVALRRVDGSVEWGSASAS-V
IAPDGTRPYGICMVEHITARKQAEAALQHMVLHDQLTGLANRTLLMERADRALAEAGHEDVGVGVIFLDLDDFKAVNDTWGHGVGDEVLTLVARRIQSVI
RMDDTAARLGGDEFVVLCPDIADEQIRQVAQRIRAEVRMPIQLSGHVFQLSVSAGVAMSRSDS-TAETLLRRADELMYSSKRQGKNLITLGSRSDKTTMM
VASQLISELGRAVRGGELVVHFQPIVALATGRCAAMEALLRWEHPEQGLLMPDMFLDVAENSPHMPAIGRFVLNEACRQAAQWTGSLAS-AAIHVNVSGR
QLEVGDLYSDVTDALNGSRLSSDRLVLELTETYAGRITPSAKADLVRLWKAGVRIAIDDVGTGFSSLSKIVDLPVDIVKIDKQFIAGLPHDARCAAITQA
VLSLGETLGLSTIAEGIETATQRELLLDWGCALGQGFLFGRSASLD--------------
>tr|V5XC98|V5XC98_MYCNE Diguanylate cyclase OS=Mycobacterium neoaurum VKM Ac-1815D GN=D174_12385 PE=4 SV=1
-------------------------------------------------------------------------DALREARDLFASVLQASEQAIIGTDPA
GRVTVFNNGAERLLGWARAEMVGRS--LLTIHHMPEVRSRAFEVLTHRVSPGHAEVREWTYVKRDGASIRVNLAVSQMSDPDGACSGYIGVATDITERAA
AEQALAESELAFDTAPMGMFLFDAAGRITRCNQAMANLLGRRVDEIPGMLVTDLCDCEED-SCSESLLRELLVGDRFEAEIALRRADGCVEWGSASAS-V
IAAGGAVPYGICMVEHITARKQAEATLQHMVSHDQLTGLANRAFLVDRVEQALSDAGRDGGTVGMIFLDLDGFKAVNDTWGHGEGDDVLTVVAQRIQSVI
RAGDTAARLGGDEFAVLCPDIADGVVQRVAERIRTEVSRPIQLSGHIVQLSVSAGVTLSQPDS-TAETLLRRADELMYSSKRSGKNSITLGGQFDTTTVM
FASQLISELERAVRLGELVVHFQPIVDLATGRCAAMEALLRWQHPEQGLLLPDRFLDVAENSPHMPAIGRFVLHEACRQAAQWTESLAS-AAIHVNVSGR
QLEVSDLYSDVTNALKSSQLTSDRLVLELTETYAGRIIQSAKADLVRLHKAGVRIAIDDVGTGFSSLSKIVDLPVDILKIDKQFIAGLPHDARCAAVTQA
VLSLGETLGLSTIAEGIETEMQRELLMDWGCALGQGFLFGRSAAQG--------------
>tr|I0IQK6|I0IQK6_LEPFC Putative PAS/PAC sensor-containing diguanylate cyclase/phosphodiesterase OS=Leptospirillum ferrooxidans (strain C2-3) GN=LFE_1877 PE=4 SV=1
------------------------------------------------------------------------------EELYLRWASERTSDLVIILSPE
GKIRYVNPSLASYLGSGEKGSSRKLESLSGKSIFPLAGSFLFSRIAGQLRDGHVNSLDFPFTGGDSELRWFSLRMTEISDDLLGVCGYECRFVDITSLKK
SEGELASQKITMNSIGDGVVAMDLSGRITFINRVAAFLMGINEESAMGQDISLFMVHEEKNQIELPLSRILREIATIPGPVAIRTSSGELIPITDSLAPI
HNHLGEIVGSIFVFQESTERRQAQEALWNMKYHDQLTGLPNDRLFRERLISFIALYPETGKGLCVFAVGIDHFKKINDTYGHGLGNEFLQQFAARLSETI
PSGDSLARLGGDEFLVLISDFLDERMAEKARQILMQMRKPFLLGEHKVSMTVSIGISVFPDDGQTEDLLIRNADIALNSVKDRGRNDFCFYSPLMNPNSQ
EEIELRADLQDAIREDSLELHYQPKVNAKTGEIVGVEALIRWDHPQKGMLRPHQFIKMAEEQGLIVSLGEWVLKRATRDAKILCERW-SRVSVSVNVSVR
QLVEPDFYEYVRRALLISGLDPSLLVLEVTESIFAKEIAEIEMNVQKVKEMGVKLSLDDFGTGFSSLGNLTRFSPDEIKVDKSFVDQMMSGGKELELIRT
MLSIGLTMRINVVIEGVETLEQRDYLFKRGANVFQGYFYSPPVPYKELLGLMSAGF----
>tr|R4KTC3|R4KTC3_9FIRM PAS domain S-box OS=Desulfotomaculum gibsoniae DSM 7213 GN=Desgi_3532 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----INPMFEKILGWNWQDLKNIK--WT-EITHSEDLQ---ADLKKQFKEGQGYSLEKRYLRPDGASVWTKMTIAPLLGGSESKSKHICLIEDISERKK
MEESLRESEVLLSHLPGMAYNYDREWTMQFVSEGCSQLTGYTPESLLYKELSFN--DLIAPEYHESLWK------EWEREYEITTAKGERKWVLEMGQGI
YNEQGEVEALEGIILDITDRKEIEDNLRYNNEHDLWTGLYNRRYLEDLLINDTKIKTTK--KRAIVGINMSTVQRLSLTYGFHYSQEIIKKVAEVLNLLC
TDKQQLFNTYENRFVFYVKDYTDNELTMFCENVVG--------TLESVFAAERIGGGIIDEDNKDLKNLLIASEKALYIF--DKDFGFCFFDKDMEAQII
REEQIKHELEADENNGGLYLQYQPILDLKSNKVCGFEALARLKSEKLGVVSPLEFIPMAEKTKLIIPIGQKVIRQAFRFLNKLKVSGYSGLTVSINVSAI
QLLRNDFNKKLFEMITEMQVNPADIGLEITESMFSDNYQEINRILGELKDSGIHIAIDDFGTGYSSLARERELHVSSLKIDKYFIDKLVSLKDERDVTSD
IISMAHKLGHCVIAEGVEHEKQRQYLTNYGCDKIQGYLISKPLNEEAAIDILKN------
>tr|K9WAN6|K9WAN6_9CYAN PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Microcoleus sp. PCC 7113 GN=Mic7113_1570 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----WNPAAQKIFGFSQQEALGKK--LC-ELIAPVAVR---PHLTSQLVAGTVHSVN-ENLTQEGRTIICEWYHTPLKESDGAVVGMLSMAQDITERQQ
AEQELRKKDTLARNFPNGAVLFDRNL--RYILAEGSELSALGLSSEMFFEPEIC--NLLEPVYHQALAG------I-----------ANRVYLLQV-LPV
TNRSGEILAGMAVAQDITERKHTEAQLWRYAYYDALTGLPNRALFSKRLGERIEAAKQH--NTGVLLLKLEHFEMVKYSLGHNMADQLIIATARRLEAHL
QPSATLARVGTDEFAILLTELQNDEATDDCIHRLLILP--FDLQGREVFSTSSIGIALLPPPSSSCEDFLRAADTHHAKV--QAHVSHAVFNPAMHEQAV
ARFQLETDLRRAIERQPFQVYYQPIISLAMGKITGFEALVRWIHPTRGMVSPMEFIPLAEETGLISFIDWWVLREACTQLRQAFAKDSASLTMSVNFSGL
HLVQLGLLERLDQVLRETGVEGCNLKLEITESGLLKNATSGTEILQELKTLGVKLSIDDFGTGYSSLARLHQLPIDTLKIDRSFVSRMGNEGESLEIIRA
IMMLAHSLEMDVIAEGVETQEQLSRLRSLNCEYGQGYFFSRPVDSQRAEELLAA------
>tr|A0A0D6NGU0|A0A0D6NGU0_9PROT Heme-regulated cyclic AMP phosphodiesterase OS=Acetobacter orientalis 21F-2 GN=Abor_007_015 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------GYTTEEVLGKH---FSIFFTEDDCQSPYRALATALAKGK-FEHEGFRIRRNGTSFWSQTTIDPVYDEKSQHIGFATITKNLTEQKK
NQDATNNLNLALEHMSQGLCLFDKNECMVICNDRFTQLLGINQEKFEGSTFDFLHTTSND--SISEIAKSVDRQKHFEH-AEPGKINHEEYFNGLTINFS
FLADG---GWVSTIEDITEKRKIENEVKILAHHDFLTGLKNRTSYQKKIDEIFG-AD----NNSLLFVDVDLFKEINDQFGHPAGDNILREVGKKIQKNL
SKKETVYRIGGDEFAIICRNSNFEDVLSLCGRILREFNTPIQTEWGDISLSVSIGVASS-SDCKNIDTWVQHTDLALYAAKEAGRNQFLRYEKGMREAIQ
KKRKLEFDLKKSLEHEDFFLVYQPVVNAQTHKVSSFEALLRWKHPVDGIIPPINFIPFAEEIGLMPSIDMWVVKAACKEALSWPH----HVSVSINISAK
TFELNNISESILKIIEDVNIDPGRVEIEITETSMLLNAEETINKIKKLTENNIKIALDDFGTGYSSLSFLRDIPFNRIKIDRSFIKDIESNIHSIAIIKA
IAGIGDALGVSITAEGVETASQISLLMRDKCYEHQGYYISKPFEQTHILPW---------
>tr|B9QXH8|B9QXH8_LABAD Putative uncharacterized protein OS=Labrenzia alexandrii (strain DSM 17067 / NCIMB 14079 / DFL-11) GN=SADFL11_1319 PE=4 SV=1
--------------------------------------------------------------------LVAAERQKAAAQARLETLLALSSDWLWEADAE
HRLTRIQKQFPDWTGSKLWEIIEDKAGL---DGSPAK---FHEVLTN--QQAEGFICEL--RGRDGSASHFEVHGEPRYDPRGKFLGHWGVARDVTRREA
LTRRLKFADQIINATRTPVIVGDAEGAIEWVNPAFEELTGYSLKEVAGRKPHFLRCDETDPETSARLTAAISGQKYWLDEIGVKRPDGGVQ--WLRVNPT
RNTDGRWVVSVGVRTDVTSLKRAEEEIRRIADTDSLTGASNRNVMIRELSKIAESAKAAS-ESALFIVDLDQFKSVNDTLGHDAGDLLLQETVARLERFV
DGGGTVARLGGDEFAFIVPGLGGDGGLSDMPDLHSALCQPVQLGSRTIPSTVSMGLARVPADGDTATEIFKSADLALYQAKASGRNGWRCYDALYRRSLE
RRQDLAQGLKEAIANDQITVAYQPQVEAATGRLVGFEALARWAHIG-TPVSPAEFVAIAEDAGLGVPLGCAVIKAACRDFANLINEGFDPGRLAINLSTS
QLCDPEFPDRVARQLDNLKVLQGRLEFEITENVLLDQREEIHRNLVRLHEFGVLISLDDFGTGYGSLKHLWRLPINKVKIDKSFVENLDTSESAATIVRT
TIVLAKSLGMGVVAEGVETRAQRNFLIDAGCSDIQGFLISKPDK----------------
>tr|A0A087NIE0|A0A087NIE0_9SPHN Putative signal transduction protein OS=Sphingobium sp. ba1 GN=IL54_4108 PE=4 SV=1
-----------------------------------------------------------------------LVAALRQSEDHYRYSVDLNPQMPWISDAA
GAILELSPKWEAVTGMPTADALGSG--WT-GAVHPADLPPLDLWHRTTSAPDSAVDVRYRLRDRSGVYRWHRARAQPRRGEDGTILKWYGTLEDIDDQVK
AENALRESELASRATNDIIWDCSLEQDRIDWSEAAFDVLGYAETR-TGTSRSWWVDHIHAD-DQKRVVASLEDFNQWVEQFRFRAADGRYLNLVARGYVV
RNKDGKPIRLLGSLHDVTAQLQYEAKLKWSASHDALTGLPNRAMFAERLDEALDDARRQGQCVGLIVLDVDRFKTINDTLGHHAGDAVLHDVAAKLSKRL
PVGATLARLGGDEFAIILPGLTPQARQETVDTIMGSLTGSLLHDGRHIDVSLSAGGALAFRDGLDAEELHKCADLALYAAKSEGPGQIRGFTPAMREAVD
MEKAMLTKARAALTNDHIIPFYQPKVNLRTGALEGFEALLRIHDQQQGLQPPGAIRAAFEDADLAVRLTDRMLDCIMADMVAWRDQGLAFGRIAFNGAPG
DFRRGDFVDRILGRMHKLGLPASLLELEVTETVFVGQLDRVHNCLETLAAAGVTIALDDFGTGYASLTHLQQFPVHTIKIDRSFVSRLNAAEGDAAIVGA
VIDLAKNLGITTVAEGIETAAQAAHLMVKGCDVGQGFLFGRPMARSQIAPILAKWDAP--
>tr|D3FAJ3|D3FAJ3_CONWI Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Conexibacter woesei (strain DSM 14684 / JCM 11494 / NBRC 100937 / ID131577) GN=Cwoe_0829 PE=4 SV=1
---------------------------------------------------------------------DRAEAELRAAEQRHRLLADNATDMILVFDPS
GVATYVSPASRELMGYDPEELVGRQ---PREFVHPDDTDEVVGARTRVAEQGGTITVTSRIRHRDGRYVWIEARVRGVVDATGEMKEGQAIVRDVSERVA
SEAALRESVTAFEAAPIGMALSDLEGRFIQVNDALCAITGYTREELEEMSFGEL-SHPADVEREAEMMASLLSGEYWM-EKRYVDVVGQVVWVAVHATLV
RAADGSPQHFLGQIQDVSERVRYEAQLQHMADHDPLTGLLNRRSFERELNQHIHRVERYGAEGAALVLDIDRFKHINDTLGHNVGDELIVKVAQTLRSRL
RDSDVLARLGGDEFAVLLPKGGQQEAEAVAESILASVRAQSVLTGRRRPITTSVGIALFGETGLSAEDVLVNADLAMYDAKEAGRDRAATFSSQEASRMK
ARITWAERIRDALEEDRFTLYAQPIVELRSGAVRQHEVLLRMLDEQGEVIPPAAFIGVAERFDLMQEIDRWVVARAIKEMGQQRRAGRD-LVFEVNISGA
STGDPDLLTIIERELRENEIDPINLVLEVTETTAVANIPRAQEFAARLAELGCRFALDDFGAGFGSFYYLKHLPFDILKIDGEFVRSCTTSQTDQLLIRA
AVEIARGMGKETIAEYVGDDETVELLRTLGVDYAQGFHLGRPAPLEQ-------------
>tr|Q2S5Y4|Q2S5Y4_SALRD Sensory box/ggdef family protein, putative OS=Salinibacter ruber (strain DSM 13855 / M31) GN=SRU_0251 PE=4 SV=1
----------------------------------------------------------------------RVQQAMRTQRDRLQRMQGVAQTGGWEYDPK
SSFTGSN-EFYRLIGLPQSTNFDLE--RAFQLYPPSVRGRVKTAAQRCLEDGSPFDMEVPLVSATGQHREVRVRGSAER-EEGRTARMTGTIQDITTRKQ
REQHLRQANALFEHSQEGFLLFDLEFVIQRVNPAYEQMSGRRADEVRGRSVRDIHGEEQGAEGEPKDWEMLKTNGSWSVTVRNERKNREERWRQVNSSAV
YDGERRVVEFQTVLRDVTQQRREEARLRHRATHDQLTGLYRDSVFRERAQQAIDASD--EDKGALLYVDLDQFKSINDKNGHHVGDAVLMEAANRICSVV
RDVDPVGRMGGDEFAVWSSSVTDETAKTMAQRITLVLDQPYAVEDRCLQVGASVGFAVCDLEDQDIDGLIQDADAAMYRAKSSPDRSLSHHGPS--AGSK
KNTSLRAEVRRGIDQNEFEPLFLPVVRLSDGNLVGFEVLARWRREDGNLDPPDVFLGVAEETGMISPITQSVLEEACRKVESLQQHRGPDVALSGNFSRQ
EFFREETHEFVRHLLEEYDLAPSNLTMEVTERLLENENQTNTAVVDRLRSLGVNVEIDDFGTGYSSFHSLLQFPTDGLKLDKGLISETTASEDACVATRS
VIEMAKSLGLRVTAEGIETTAQLEVLRDLGCPLGQGFLFSRPVPAGDLPALIDS------
>tr|D5AS03|D5AS03_RHOCB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
----------------------------------------------------------------------RSAEAVRRAHDRMVTMAENAPGAIFEWQRD
GSFAFFSAALPELLGLSGEALKADGAA-VFTRILPEDIPSVQAAVTHSVETLTRFEILHRIGHPQRGLRWLHVSASPFLQDNGTIV-WYGNAMDVTEQIE
AKRREEQAASIASIAPVGLYEFDGSASFPYASPYLEDLLGIEFGLFSIAFANVQFDEL--PDFLTGQGAGPGMLDLWNQRFRVRHPRRGDIWLANSATSK
PQPDGSVVWT-GALHDVTADVAREAENERQALHDGLTGLPNRRSYDNVLARRIADAAAAGPRDCLLRVDLDHFKHVNDTLGHEAGDMVLQRVADVLRAEL
RGGDFAARIGGDEFSIILAPGQSGHAREVVERMQARLAEPLWFDGRQCRFGASFGIAETEDIAAMGTEIQLFADAALYRAKEGGRNRMEFFTPELHQNIL
FDRKLAGEIQEGLDRGEFVPFFQSQICARTGRLTGVETLLRWRHPERGLLVPDAFMHVAVQLRLVSEIDRVMMEKSAAALTSWRARGLIVPKISFNVSSG
RMHDPDVVRAARAIAE----GETKVTFELLESILVEEESEVFRHLDALRDAGIEIEIDDFGSGHASIIGLMQIAPSALKIDQRIVAPVARDPRSKNLVRA
IVEIAETLGIATVAEGVETWAQAEILRDLGCDVLQGYLFSMPQSAEDFMRICTQ------
>tr|D5APL7|D5APL7_RHOCB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
----------------------------------------------------------------------------------------------------
---------------------------------------------------GAAIEMRLSVRHPLRGLRWVSVAAAPFRREDASVC-WFGQILDVTENVE
TEARAALAASIAAVAPAGLYEIEGAATIPYASPHFRNLLGLDHRDTIGEAQEVKLDDL--PAFLTRDAASPVPPGGVARRFCIQHPLRGAVWLSNSATAK
PQPDGTVVWT-GALHDVTGDVRREAENEWQALHDGLTGLPNRRYYDQVLANRIEQAKAGGKSGCTLRIDLDHFKHVNDTLGHDAGDLVLCRVAEVLRASL
RQGDFAARLGGDEFSVILARGLGEDAGALIRRVQDRLVEPLMFAGRQCRFGASFGIAEAEDLASTGPEIQFFADAALYRAKETGRNRMEFFTPELHQNLR
RDRELAAEIQEGLDRDEFEPFFQAQVSARDHRLTGVETLLRWRHPERGLLTPHAFMHVAEQLRLVPEIDRVVMERSRESLAFWRERGLIVPKISFNVSSG
RMHDPDVVKAAQTIAR----GETRVTFELLESILVEDESDLFRHLDAIREAGIDIEIDDFGSGHASIIGLMQIGPSALKIDRRIVEPLGRDPQARHLVRA
IIEIAETLGTATVAEGVETEAQAEILRDLGCDVLQGFLFSVPLSAPDFVAFWQR------
>tr|D5ANQ6|D5ANQ6_RHOCB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
----------------------------------------------------------------------ETLEELRLAHERLDTIAQNVPGALFEMQRS
DSFPYFTHKFVELLGVTAADMLAGGPA-VFRNIPPAEFAAVYAAFERSRETLSQVEARHRVLLPDGSTRWVNLWASPSVQADGRVR-WFGKALDITDRLE
MEARATAAASILDIVPVGLFEYGGSADFPYTSGRFSELVGLDRAAIDGGLDRVLPEDR--VAMEEMTRQSAASLTPWRMRFRYIHPERGQIWLMAASLPE
AKPDGTVVWT-GALYDATPDVLREAENEHLALHDGLTRLPNRRYFDRHIETRLRAAELGGPRDCVLQIDLDHFKQINDTLGHEAGDRVLMRVADLMRSSL
QADDFAARLGGDEFCLLLAPGSTVRARKVLERLRKGLDEPLRYRGHPCRISASFGVVIAKNITDLAEELQLYADAALYRAKATGRNRVEIFDHAMAEQMH
LDRMMAAQFSAAFERDEFEPWFQPQVRAQDLRLAGVEVLVRWRNPERGLLTPDAFLRVARDLRIVPEIDRVMMEKTAAVLERLETTGIILPRISFNVCTG
RLHDPALPAAVRRVGR----GRTRVALELRETGDWQEEGCDLRTLARLRAEGIDIEIDDFGSGQTSILGLMEIRPAALKIDRRIVAALRRDTHEADLVRQ
IVQIARTLGVATIAEGVETMAQAETLRQMGCDILQGYLFAPPLEEAAFRDYLDR------
>tr|D6CLU5|D6CLU5_THIA3 Thiomonas sp. str. 3As chromosome, complete genome OS=Thiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As) GN=THI_291
------------------------------------------------------------------------TTRLHASDTSLDLLRTSPGLTVWELDLQ
TGQLWLDEAHRHEKTFTIPE-------WM-GHVAPADLPALEQAIARISAPDFVQTVETRFIRVDGSTVTTMNHGMVRERPDGVATRIFGLTWDITELRQ
TQTRLQRSEMLAELSSEWFWESDPNDVLTYITRSSRRASPLATLNLVGHNLNSLYPGQE---F-SPEWAQLRFLMEEHEEVRVPRLGPDLLWWRIDASPM
IDHLGLFQGYRGVVRDVTKAHQAEEKLELAAYRDTLTGLANRTLFEKHVEDAIAVTP-PGQSFAVLFIDLDRFKLINDALGHAVGDKVLVETAQRLVQLA
RPNNTAARFGGDEFLILARDAHDAQALRMAMLVQQSLGEPMHHAERTLQTTASIGVAVFPQHGRTTAELLGRADAAMHESKMLGRNRVESFSVALQSRIE
RRSQLEEELRAAIANRRFEVHFQPIWSRKQNEIAGVEALARWTRGNGERVQPDEFITILADCGLLDSFGPVMMSVALEGFARLRKEGFT-GTMAYNVSPR
QLHVNACVSCIFDMAASFDVPRDKLVLELTENVEIEHNPDLLAVFEQFRQMGVQLSLDDFGVGYSNLGYLTRLPVSQIKIDRAIASGVSTDRFKAAIARA
TLTMAKTLNLEVVAEGVETVADLLWMERAGCPMIQGWVFSRALNLQQTLNLLRDL-----
>tr|E6PVY5|E6PVY5_9ZZZZ Putative Adenylyl and guanylyl cyclase/Phospholipase A2 with PAS, EAL and GGDEF domains OS=mine drainage metagenome GN=CARN2_02
------------------------------------------------------------------------RSANKLQQDRASLLRHASGATFWTLDLQ
QGVLWTNPSLREEAHLTLAE-------LL-ALVPETDRNGVLKGLQAVMRSGVSPSVEARICRTDGSTIWTRSQGLVSRRASGEPLELMGISVDISATKK
ALDDLRDSETFAELSSDWFWELDAEGRFTNLSASALRNRQQVREAVLGRQWQSLNPALA---A-LPQWKALAALMQRQLPFHLPRSAG-TRWWRLNGAPV
RDAQSLLSGWRGVASDITEQREAEDKLYSTAYTDALTGLSNRTGFERLLEAALQEVRGSVVGGALLFIDLDQFKQINDSLGHSMGDRVLAEAAQRIYATR
RTGDLIGRFGGDEFLVYSRHVDAANDPALAERLRADLARPYDLDGRILHTTVSVGVAQFPRDGRTIAELLSHADTALHEAKTQGRNRVQAFTPQLLAKLQ
RRTQLEAELHAALEQQSFRIALQPIARLERHGVVGFEALARWTRPNGEEIGPAEFIPMIQDLGLISAFGFLIIRLSLQALRRLRDDGYT-GHMSVNVSPA
QLK-SGCVECLRDELAAAGIEPAALTIEITENQQVMSCPDCLLTLDTIRAMGVRVSLDDFGVGFSNLEYITRLPATQLKIDRTFTHGVAQDRYKAAVVTA
TLAMAASLGMDAVAEGVKDAADLRWIERAGCSQVQGWALWPAMDLDAACALLQAT-----
>tr|C3XB77|C3XB77_OXAFO Diguanylate cyclase (GGDEF) domain protein OS=Oxalobacter formigenes OXCC13 GN=OFBG_01481 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------RDMIHPEDANRLEDNMRRSFSEGLDYRAEFRKLLQDGSWRWASLTVFPLSGDAGSDEMYLVFIMDIDARKQ
VEEIALQNATIVEQTNTLVFEWVVNERYISQEIPKRFAGNYDDRDIMWIDDHVI--HPDDMILFEQFLKGIRKQNHVEMVARYKKRDGSYAWNRVTLSCL
YAQDGKPHRYIGTINDVDNATRSVQTLKYRAEYDVLTGIYNMQAFYDRASSMMRNNP--ERQYYIVRLDIDRFKVINDLYGLEEGDRLLKTIAGLLSDRM
KENAAYGRISGDIFCACVA-YSREEIIHFVQDVAARLAE-YPLAS---KIIPSFGICKVDNVQTPINVLCDWANLALKTVKGSFYPIYAFYDETLRHQIL
SEKKIESEMDLALLRKEFLMYLQPKVDIATSKIIGAEGLVRWNHPEEGLIPPDRFVPLFEKNGFIIQMDEYIWEQACICLKRWVDMGLEPVPVSVNVSRM
HIHDNKLNEKLLELIRKYDLPPELLELELTESIFFENEELLVGTIRKLQQDGFSISLDDFGAGYSSLNMLKDLSIETIKLDRGFFNEVIVTPRGKTVVAH
TISLAKALNINIIAEGVENQEQAEFLLNAGCPFAQGYYYSMPVPIGKFEELAF-------
>tr|C3X511|C3X511_OXAFO Diguanylate cyclase (GGDEF) domain-containing protein OS=Oxalobacter formigenes HOxBLS GN=OFAG_01450 PE=4 SV=2
----------------------------------------------------------------------------------------------------
-----------------------------ENMIHPEDAPRLADLVRKSFRDGQEYRAEFRKLWLDGTYHWASLTVFPLPADESGDEMYLVFIMDIDDKKR
AEEVALQKETIIEQTDTLVFEWIMGSRYLSPEIPLRFAGRYDERDLLHIDDGVI--HADDLSMLDELKAAIHERSHVEMVARFKKRDGHYAWHRITLSCL
YDREGKPRRYIGTINDIDNETRSVKALKYRAEFDVLTGIYNMQTFYDRASQMMESAP--GQQFYIVRLDIDRFKVINDLYGLEEGDCLLKTIAAMLSEKL
KERAVYGRISGDIFCACVD-CSREQVIEFVQEIAAALAE-YPLAS---KVIPSFGICRVDNVRTPINVLCDWANLALKTVKGSFYPFYAFYDETLRDQIL
SEKKIENEMDAALENREFVLYFQPKVDIATSRIVGAEGLVRWQHPSEGTIPPDQFIPLFERNGFIIQLDEFVWEQACVCLRKWIDQGREPVPISVNVSRM
HIHDEGLSAKLASLIGKYNLSPKWLELELTESIFFENADLLVRTVQNLQKEGFRFSLDDFGAGYSSLNMLKSLPVETIKLDRGFFNEVIVTSRGKTVVAH
TISLAKALNIDVIAEGVENREQTEFLLGAGCSLAQGYYYSPPVSATEFEIMAF-------
>tr|E5Y1P0|E5Y1P0_BILWA Diguanylate cyclase (GGDEF) domain-containing protein OS=Bilophila wadsworthia 3_1_6 GN=HMPREF0179_00111 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-----------------------------RNMLFPEDRTRLEDALRQNFAAGREYLGEFRKLWHDQEYHWASITMFPVAQPDGGDEIYLAFIMDIGDKKQ
AEEVAQQNITIVEQTDTLVFEWNLDTRYISPEIVARFAGNYDHRDLMHVEDLVI--HPDDLPLLTAFLKDSRIQRYTEMTARFRKRDSVYIWCKAALTCL
HDDKGNPKRYIGTLNDVDSATRSVLALKYRAEFDLLTDLYNMHTFYSQAAQAVHAYP--ERRYSIVRMDIDRFKVINDLYGLKEGDKLLIAIADLLREKM
AGHSVYGRLGGDVFCLCVD-YSRERILALIKELTDRLAD-YPLPY---KVVPSFGICEVDNIDTPINVLCDWANLALKTIKGNYLNSYAFYDGKLRERIL
EEKKIENQMHDALLQGQFVLYLQPKVHIPTSRIIGSEGLVRWIHPTEGLMPPDRFIPLFEKNGFIIRLDEYIWEQACITLRRWIDHGLTPTPISVNMSRM
HIHDPRLREKLLDLMRRYELPPHLLELELTESAFLENESGLFESMKALQAFGFQFSMDDFGSGYSSLNMLKSMPVDFIKIDRGFLNEVVTTERGKTVIRF
SISLAREMSIKVIAEGVETEEQAAFLLQAGCAYAQGYFYSRPLPIPQFEALAF-------
>tr|U5T6C1|U5T6C1_9GAMM Uncharacterized protein OS=Spiribacter sp. UAH-SP71 GN=SPICUR_03600 PE=4 SV=1
---------------------------------------------------------------TDVSREQAALASLDMQKRRHESLVNSVASYIWHMDAD
GVIRDIDRRWLSLAGLPKGDTRPALADIRGTYTAQRFRE---RW-AQALEAVTPFEVTYPLPANATSPRWFQDRIAPVLGDEGQLLEWFGVSQEVTALRQ
AEQNLF---RVIQNAPTGMLMVNSDGTIEYANEQAAHLFDYSVEALKGMSVDALVRDRHHRRFMA--SPSLRRMG-MNREVKGVRRDGTEFSAEIGLNSF
SDD--HERRVIASITDKTELNDAHQALERAAYTDRVTGLLSRDGFAWKLDE-LREARVLHPASLIVSIDISGLREINNAQGFAVGDEVLREAGRRLTAAV
GHANRIARPAGGEFLVIVA-VDRHTPARWRQRLAALFDTPFEVSGFRVFIGVAFGYARVGTETVDSETLMNNAELALRRSQQRLSVTWTQYTRALEQHTR
AVVTTTRELRSALECNDLRLYYQPKVDMNDGRLVSAEALLRWQHPERGLLPPAAFIPLAEQSQLIAPMGEWVLRQACQDMRQWQDAGLTVAPISVNISLV
QFQLGSVPDIVSRALTDFGIAPHQLTLEITESVFEEHCEALKVDLNAINRMGVKLSLDDFGMGYSSLGHLNDYPFDEIKIDKSFIWQLSGRAYGQAIVKA
VHAIAEAIGAQVVAEGVESAEHVEALQRLGCWIGQGFYYSRPMPASQWQ-----------
>tr|U5W2A6|U5W2A6_9ACTO Putative diguanylate cyclase/phosphodiesterase with PAS sensor OS=Actinoplanes friuliensis DSM 7358 GN=AFR_19165 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------PWVWALLHGLAVLLAVFQVV---AWGLTEAEERR
AQDSLAASQVAFDETPVPMAMLAPDGRLQRTNSAYRAWLGLPDELPPGFSVSDLTGVDDEPGNTFAELVDSPDATTITRAYR-RHDDNSLIYVEIHSNGL
RDRQGRLQSVFVHCLDVTRQQEHEAALRRQVRQDSLTGLLSRAAFEVDLVGLLAGSA---GPASVLYLDVDRFKTINDGSGHSAGDDVLRALAARLRAVV
PQGSLVARLGGDEFVVALPGSI-DTGLEVGRAVLASLAEALPVAGGRLQLSMSIGLALAH-GPDQAEQAVLAADTAMYTAKRAGGNRLEIFNDQMRVAVQ
QRIVAESRLRQALDGATLPVWFQPIVSPATGLIVGAEALVRMWTTEGELLAPGHFITTAEETGLVVPLGEHVLETALRHLTEWRHEL---GYVSVNVSPR
QLSEPDFVPMLARLLAGTLVDPSRLVLEITETALLSTSVDLKQRLDAIKALGVRLALDDFGTGYSSLTWLQSVPADIVKLDRSFVAGLADDPRKASIISA
VLWLARSLNMSVVAEGVEDLADWEALRQADCPAIQGYFFSRPVTAGDFQEMLAKT-----
>tr|R4LRG9|R4LRG9_9ACTO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Actinoplanes sp. N902-109 GN=L083_4330 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------PWLWAVLHGVAVLMAAFQVV---AWRLSEFEEQR
AQDNLDDSQIAFDETPVPTVMIGPDGKLLRTNAAYRAWLGLPDDLPAGFSVTDLTAVGTDLDNVFEKLRDARTPVTITERYW-RHDNGSLMWVETHGTSL
YDRGGRLRAIFVHCIDVTVTREHEAALQHRVEHDPLTGLLSRTGFEQGLAAMLDGRP---LPASVLYLDVDRFKSINDSSGHAAGDEVLRALARRLTAAV
PAGSLVARLGGDEFVLALPLPP-DAGHAAGKTLIAAIAEPLEIDDSRIQLSVSIGLAPAR-GRAEAEHAVLAADTAMYAAKRAGGNRIEVFSDQMRVAVQ
DRITAEARLRNALDGHTLPVWFQPIVA-GDGRIVGAEALVRMRTPQDQILAPGHFIAAAEETGLVVPLGEHVLTSALRHLLAWHHEL---GYVSVNVSPR
QLSEPGFVPMLRDLLDRPQLDPARLVLEITETAVLATSVDLQARLHAIKALGVRIALDDFGTGYSSLTWLQSVPADIVKLDRSFVAGLASDPSKSSIISA
VLWLAQSLGMTTVAEGVEDLDDWQTLCNLGCPALQGYYFSRPLPAGEFDAMLRRG-----
>tr|I0H6J8|I0H6J8_ACTM4 Putative diguanylate cyclase/phosphodiesterase with PAS sensor OS=Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / C
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------PLVWALLHGASVLLAGFQIV---SWRLTEVEEDR
ARENLDESQVAFDATPVPMAMFSPDGLALRTNAAYRVWLGLPEELPAGFGLKDLIPVDGDQASILTLFAESRESRTITRQYR-RP-DGSLIWVEVHGTGL
YDRNDQLRLIYVHCFDVTATRDHEAELSYQVRHDTLTGLLSRKAFEHDLAALLTGST---EPVSVIYLDVDRFKVINDGAGHTTGDDVLRALATRLAAVV
PAGAVLARLGGDEFVVALTGPA-GTGLRVGNSILAAVHEPVA----GVPVSLSIGVTTAF-GGVGADEVVLAADTAMYAAKRAGGNRLQVFTEDLRVPVQ
ERIAAEARLRRALAGSTLPLWFQPVVSTATGQIVGAEALVRMRTEQGTVLAPGLFIGAAEETGLIVPLGDHVLRSAVEHLVHWSDRL---GYVSVNVSPR
QLAEPDFVPKVASLLAEPYLDPSRLVLEVTETALISSTVDVSERLALLKQLGVRIALDDFGTGYSSLTWLKSLPADVVKLDRSFVAGLAEDARKASIISA
VLWLARSLGMSTIAEGVEEIADWDALRAAGCPAIQGYLISKPLPAPEFDMLLTTG-----
>tr|A0A0A6USN9|A0A0A6USN9_ACTUT Diguanylate cyclase OS=Actinoplanes utahensis GN=MB27_07815 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------------PLTWALLHGVAVLAASFQVV---AWRFNETEEQR
AEEHLSESRVAFDETPVPMAMYTPDGRMIRTNAAYREWLRLPAVLPDGFSLHDLAPAGPDEPQLGRMLTASHEPVTVTRQYR-RTDDGSLIWAQTHATGL
YGRDGELRMIFVHCLDVTAVRDHEAELRQQVRHDSLTGLLSRKAFEHDLAELLTASA---QPVSVIYLDVDRFKSINDGSGHGSGDDVLRGLARRLAGVV
PPGALVARLGGDEFIAALSGPS-GTGLRVGNGILASLAEPLSVGGSELPVSVSVGVTTAF-GPVPADDVVLAADTAMYAAKRAGGNRIQVYTDELRVPVQ
EKIAAEGRLRRALAGVTLPLWFQPVVSTVTGQISGAEALVRMRTPEGEILSPYHFIGAAEETGLIVPLGEHVLRSAVEHLLHWSDRL---GYVSVNVSPR
QLAEPDFAPMVAGVLAGPGFDPSRIVLEITETALLTSTVDVSERLTSLKQLGVRIALDDFGTGYSSLTWLKSLPADIVKLDRSFVAGLAEDPRKASIIQA
VLWLARSLSMSTIAEGVEERADWEALRAAGCPAVQGYFFSRPLPAAEFDRMLRAA-----
>tr|A0A0D8HHM9|A0A0D8HHM9_9ACTN Phytochrome-like protein cph2 OS=Acidithrix ferrooxidans GN=cph22 PE=4 SV=1
-------------------------------------------------------------------------------------IVQAMSELVWAISDD
GRIVWASPSHREVLGLSPSLLEGRRMSVYGDLLGAMDQL--------------LFEIE----DHRGNLHLLEAVALPVIHSSGAT--TVVSARDVTERRK
MEREVEESESIVEASGQGIWVVSLDGRVTYANRAMEALIDRDASDIVGCYVDFLDPMSATDPTLE--WGSGDSFPEMQHELILLRGDGKTVHGLAKISPI
RDSFGNVISRLAVVADISRHKQNESELEAALERDSLTGLLNRRGAEKGY-LEIVSNLDDGRLVALFFLDLDRFKLINDTRGHLVGDRLLVSVAKRMISAG
RDQDVVARLGGDEFIVVAGGFKDAGAEAFGVRIARNFAKPFVIDGEDYFSSASIGVATGLSDT-PWDELLRDADTAMYKAKESRSSKVAFFDKSFRSSAE
RRMVVEAALRQSLSRDEIYMAYQPILDIQSGLVVGYESLMRWNCKKLGTIGPDEFIPIAEDSGLIHLHGAFALSASVSALRTFQSFDPRRPFIAVNVSMR
QLETGSRSS-FIDLIASKNLSKGELVLEITESEMMRYPSEIAPLLRDLQSIGVLISIDDFGTGYSSLAQLSSLAPDIVKIDKQFVAKLEAD-DSRQIASA
IVAMCDALGVSTVAEGVETKMQLELLASIGCTFAQGYYIAPAL-----------------
>tr|F7PRI4|F7PRI4_9BACT Putative signaling protein OS=Haloplasma contractile SSD-17B GN=HLPCO_002172 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------YLRYIHENDVIDLREKFNKFINEDSEFRVEYRIKLEQMTYAWVLLVAQK---STESEHNFYGVQIDITELKQ
TRKELETNKLVVEHSTDLIAKIDPNGTLLFASNSLFKVFNRDQKELIGRNIFDINK-EH--GIKEEEWFKLTPPYSIQRTNKIVTNEGIKYIIWNHD-AI
LDEQDHVSYIFSVGHDITDLKKANEQLQYEAEHDLLTGLLNRRGIFKYLDHLEQHA----KKIAAFFIDIDEFKNINDFYGHDIGDDIIKLVAKRLKYIN
IPNKIVSRLSGDEFLLLIIDFDSSDLEIYREKLQSVFSEPYFLDELTLGISASLGLAVYPNDTKDPLELITYADIAMYASKRHSSKKCVRITKQLYEDVT
YKFNMTNKIKQAIESEEFFMVYQGVYDVIKSQNTFIEALVRWKDDSNTTLLPGEFIPLAEESGLMIELDQTIINTTLKEFSAIKQNDRYHLKVTINISRN
KLLQVNFPERLKKITDHYKLKSSDICIEINENTFIDKINLCKEQIKRLKELGYLIAIDDFGKEYSSLSILNKVDFDIIKVDKTFVDGIKD-KSNIEIVKM
ILNVARVKGKQVIVEGIETKEQKDVLEKLGVRLMQGYYFNYPSKLE--------------
>tr|U2FLL6|U2FLL6_9BACT Sensor diguanylate cyclase-phosphodiesterase CHASE4 protein OS=Haloplasma contractile SSD-17B GN=HLPCO_000306 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------YMELIDPSDRTRFRDLFESLKNDKEQINVEYRIKYPNSQKHWVSCRISP---KQSDANNILGIQIDITKIKE
IQHDLKESEVIIENSSDIISRINHLGQLEYVSNSYCNLFGKSKNELIGKKIFDVTD-TN--TYEETDWINTRPPYQFTQEELVSTNNGYKYIEWINN-SI
LNKNGKLDYVVSIGHDITEYKKHHEMLKHIAIHDQLTGLLNRRGLFEKLDSLQK-S----SKLALFFIDIDNFKSINDFYSHELGDQLIIKIAERLSKLE
EEGCIISRLSGDEFVLIHPNYHSEQIITIKNEIQQTIASKFVVNEHEIYITASIGLSLYPDDTDDLYKLLSYADLAMYESKNTTKNNCFRFTKDIYTTMN
QRFELINDLKVAIENREFKLVYQPILDLNSKHVEYIEALVRWDHKDKGLISPGQFLKIAEDIGVMTEIDSIVIDKSLSEFKELKESINTRVVITINISPM
KLLHNSFIAELTSKINEYNIDSNEVCIEINENTFMNNIEECAKQISELRKLGVQVALDDFGREYSSLSILDRVEFDIIKLDGLFVQNVKN-ERNRRIIKM
LVDNSETFGEKVIVEGIETEEHDFQLRQLSCKLGQGFYYARPTTID--------------
>tr|Q3IWS8|Q3IWS8_RHOS4 Rhodobacter sphaeroides 2.4.1 chromosome 2, complete sequence OS=Rhodobacter sphaeroides (strain ATCC 17023 / 2.4.1 / NCIB 8253
----------------------------------------------------------------------------------------------------
-------------------------------------------------------------YTAAGQPYWIRFNAHPLSDADGRYAGHASVETVITDRKV
LERELATRNAVLQTSVSAIVALNAEGGIVYANDEARRLLGLRMEAVLETLD-----GRP--LPEADMPSAVRATGAPLHRYAIRRPDGQFGILSINAAPL
PQA-ADDARIVISVTDITHAEASAERLRRQAAEDPLTGLANRRALADAVETRLTEA----APFALVMLDLDNFKAVNDLQRHDTGDAVLRIAADRLRAVA
GADCLVARMGGDEFMVLAPGTDAASAPRLAEALRAAISAPIEVGRQPVHLAASAGIALHPEHGTSMALLMTGADIALHAAKRAGRNRSVLLSQAQFAAEA
RRSAITQALAADVE-ADLRLVFQPQFRAC-GAFDGAEALLRWTDPRLGEIGPAEFIPIAEEAGLIQRIDAHVAVLAARQLGLWARRGWR-HRLAVNASAQ
TFARAGFAEELLQHLAEEDVCPQQLVVELTDTSLATLSSVADHNIATLRRAGVGIAIDDFGTGYASLSYLHRIEATEIKIDRGFVAGLETAEDSKPLIQA
ILSLAHALGLAVTAEGVETERQRSWLSAEGCDRLQGYLLGRPLPVEAFEAAF--------
>tr|A0A011NZ01|A0A011NZ01_9PROT Putative diguanylate cyclase YegE OS=Candidatus Accumulibacter sp. BA-94 GN=yegE_1 PE=4 SV=1
------------------------------------------------------------------ERLLRAQEEIEAQRSFLRSVIDASPHFIFVIDRA
GRIRLANQSLAKRFGQTPEQMVGRA---QADFVSDPQLQMLRSD-DEAIAACERIEREVSFIGRSGEERWFHTIKVPLKDASGAVEQLIGVSIDVTDRKR
AERRLLEARVTLDSIGDAVITTDALGRIDYMNPVAESLTGWTVAEARGRPAGVVHEETRVA-VIDPIQRCLQETGSLPGPCVLLARDGREHDINDSAAPI
HRGGGALQGVVLVFHNVTETRQLARQLAHDATHDALTGLINRAEFERRLARAVSSAQDGGARHVLCYIDLDQFKVVNDTAGHAAGDELLKQIKALLAGTF
RESDTLARIGGDEFALLQENCPLERGHAVAHAALRTICQSFSWEGRSYQVGASIGLVAITAETQDTAELLTRADVACYTAKELGRNRVHVYQPTDTETVQ
RHSELAAGLRDALERGLFRLHYQPIVGLAGFRILRYEALLRVVHDAGELVLPAAFIPAAERFGLMGAIDRWVIRRAFQEYAQGI--GTTGATLAINLSGN
SLSDESLLQFIEIQLAEFSFPAERACFEITETAAIQNLRPALGVMAALKRHGCQLALDDFGSGLSSFHYLKTLPVDFLKIDGSFVKDICSSARDEALVAA
INQMSHALGLRTVAEYVESRAIVDRLIDLGVDYAQGYFFGKPAPWGE-------------
>tr|C7RRQ6|C7RRQ6_ACCPU Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Accumulibacter phosphatis
------------------------------------------------------------------ERLLHAQREIEQQRAFLRAVIDANPHFVFVIDGQ
GTIRLANRSLAVSFDLTPAQMVGHA---LPDFVTDPDLQTLRDD-DRAILSGRRVEREIRFVDRAGVVRWFHTIKAPIVNGDGEVEQLIGVCSDISERKL
AEQALFEAKVTLHSIGDAVITTDASGHVDYLNPVAEALTGWTTAEARGRSSGIVHDQTRRP-VADPVSRCLQQGRALASHSLLVARDGQEYDIDDSAAPI
RGRDNQLLGVVLVFRNVTETRELARQLAHDATHDALTGLINRPEFERRLQRAVTSARQDGARHVLCYLDLDQFKVVNDTAGHAAGDELLQQINTILAGMF
RESDTLARIGGDEFALLQENCPLDRAYAIAQSVVRNVRERFNWQGRSYQIGVSIGLVPITAETQDTVQLLTEADIACYTAKELGRNRVHVYQRTDSESVQ
RHSEIAAGLRDALDQGLFRLHYQPIVALQGFRTVRYEALLRVAHPGGELVLPAAFIPAAERYNLMGAIDRWVIQAAFREYANGV--GLGGARLAINLSGN
SLSDESLLAFIESQFVEHAFPPERACFEITETAAIQNLGPALGLMAALKGHGCHLALDDFGSGLSSFHYLKTLPVDYLKIDGSFVKDMCEDPRDDALVAA
INQMSHAMGIQTVAEYVCSESIAERLCELGVDYAQGYFFGKPMPWGE-------------
>tr|A0A060UT44|A0A060UT44_9GAMM Putative Diguanylate cyclase OS=Acidithiobacillus ferrivorans GN=AFERRI_560015 PE=4 SV=1
-----------------------------------------------------------------------------------AALLNSLTVGVNVVRPE
RVVERANARILEIYGISSMEEMVGH---SAYEFHPDMETFVGEFSISVLAQGHGILRDVPYQRRDGTVIYIDLSGQKMRTRGGEPERIIWTHVDATERHW
NEETIRQLNSLLANTITGINLVQPERIIREVNQGFLAILGYQNADVLGHSTHEIYPDSENNQKMAQLAQELARGGASLKDVAVKRRDGRMIYVDVSGQRL
MTDPEH-PLIVWTSIDVTERHQLMEDLSRQSSTDLLTALPNRRALDMEMDRAIARANRNQTLLAVCMVDLDSFKPVNDSYGHEAGDTVLVALGKRLKASL
RKSDFVARLGGDEFVLLIEDLDHNSLAPIMNKIGDIIREPIPLEGQMVQVGLSMGVALYPFDGDNSDMLFRLADQALYESKANKADRLQFWTI-YGQETS
KH---FNRYQKLFRENGLRVFYQPVLDNRSRRIVGMEALARLQDTDGRIIAPMEFLPYFKEDDLY-DLTWQVFSQTLADIQRIDAEGPEDLWASVNLHPS
SLNER-CLAYLQVALAENPINPERITFEILEGGEFLNTEDAVEQLEDLRALGVRIALDDVGSAYSSLLRLKILPVDEIKLDQGFVRTLEQRPEDLYFVIM
MQHLAENFGVSLVVEGVETDDILDALTVLDVEIFQGYAIARPLPLEALLQFLKH------
>tr|D5AQE3|D5AQE3_RHOCB Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)
----------------------------------------------------------------------------------------ITPTSSWNVDLR
SGALNVSASWKDRLGYGAEDLEPLTHDWA-RMSHPEDVAGFESATRARLRRGALVQHLSRSRHRLGH--WVTFLSFCVRWPAGEISLLMGCDLDMTAVST
LEGALARERTILDALPSGKIVLDAQDRIVLANPEACALMGCGTGAVCGRAMFLLPIEEGRADLCAAMED-----PEHSGLIRLRRA-GRLRLLQVDLVVL
PGGDGRL---LLSLSDITTLHDLGQQLRFIATHDLMTGLPDRYLMMRRLGERLTCLEAEGGGIAVLCIDFDNHRLINDTLGHETADQLIKSAAKRLEQGL
PEGALLARTNEDEFVVLLPGADALAAESRSWDIVRAFARPMRLQRRQCFLTVSIGVALHAGPGGCAEALLRAADMAMHQSKARGRNTVTLFSPEIGAQFE
RRTAVAQALHRALEESSFELHLQPKFDVREGRLIGAEALLRLTDAELGPISPAEFIPVAEVDGLVSAIDLEVMRLAGTMMADWAARGIR-LPLAVNINAT
TLDEPGHADL-AERLLRVGLDPEQVTVELTETGLAAPGLRQRRNLERLRDVGYKIAIDDFGTGQSALGVLQSLPVAEIKIDRSFVRGLEGPEPARALMRA
ILAMAGALGLRAIAEGVETEAQFSILKEEGCPAMQGFLLGRPLGLRSFEARY--------
>tr|B0CD40|B0CD40_ACAM1 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Acaryochloris marina (strain MBIC 11017) GN=AM1_0582 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------WL-DQIHPEDRHLLETLIDQDFQGEDQFELEYRWQ-SDGQPFM-CDRGVIQRDAQGVPIRVVGVLTNIADFKR
LEENAQQQITLLADISIVIFKTDLAGHWTYLNPAWSKLTGISLEDSLGKPIDFVHPDDRPG--LQEAFHNLQTSESYNHELRFFCQQGGCAWVVVHNHVI
RAEDGTCIGTAGTLEDASERKQTEQALLHDALHDGLTQLPNRVLFMDRLEQACRSFQRHPEIFAVLFLDLDRFKIINDTLGHMVGDQLLVAVAHRLQTCL
RPEDTVARLGGDEFTLLLPNIDQEDAMHISDRILQSLKEPFTLDHTEVFITVSIGIAMSGNPEQKPDDLLRHADIALYRAKANGKGCYAVFSPEMPLQPL
AQVQIETEVRQALDDEEFRLYCQPVHSLENNEVWGFTLQMYWQHPHKGVLPSFEFLPSVTDTGLQRSLGWWVLRKACAQLHQWQRMPTEPLSIWVAVSEA
QLTSSNFLSKFERLLEKHDINPQHLVLELPPSLWPRPSKKVLAHLQDVHSRGVQLARVQDNQDFDWLSGEESLPVDWVKLSSTLLGNLDQQGY-LESIHS
LFILAASAEIKMLADGIQTPKQRLLMSALKCDYGQGHNFTDPIPAHAADPWLE-------
>tr|C8W213|C8W213_DESAS Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Desulfotomaculum acetoxidans (strain ATCC 49208 / DSM 771 / VKM B-1644) GN=Dtox_0767 PE=4 SV=1
--------------------------------------------------------------------VKRIVNALRESEAGLAKAQRIARVGNWEWDIE
NDKIYWSDEIYHMLNMKTGEFGGNFES-LMDFIHQDDRDEFKKSIEIALNENKRSCIDYRIITPGGVIRAVYGQGEVIFNERGKPVRMFGIVQDITERKK
NEEKLHMARDIIEFLPFATFVVDGRKTVIAWNKAMEELTGVSNAEVFGKDDYIFCEDKETEA----LYEFIERKGNTLAHVNFIKKST-EIVMWASASPL
FDNAGNLVGAIETIRDITERRNMEKELKYLASHDFLTGIHNRYSLEKCLEQAVKKVA-EGVKSALLFIDLDNFKLVNDTLGHAAGDQLLKTLSATIGSFL
QGGHRIFRFGGDEFAVLLENVTVEEAGMTAENLRLLIEEEFCLTKTCFNMTISIGIVIIDG-ILDFHKILAYADNSLYKAKEGGRNRVVFAQADVTARMS
ETNHKIALIKTALKEDRFILYLQPVVRMKDGKITHHETLIRMLGDNGEIISPNYFLTVAERFGLIAQIDRWVVQAAMKLLME-----YPDLKLFINLSGV
SMGDMSLLDAIEKDIIGSNLDTSRIGFEITETSAMRDIRQAEEWIGRIKKLGCSFALDDFGVGFSSFSYLKILPVDYLKIDGTFVCDIYKDSTHAALVSS
MNTIARTLGKKTIAEFVENQQIINMLIEIGVEYGQGFYLAEPSPVP--------------
>tr|F8IEB6|F8IEB6_ALIAT Diguanylate cyclase with PAS/PAC sensor OS=Alicyclobacillus acidocaldarius (strain Tc-4-1) GN=pleD PE=4 SV=1
---------------------------------------------------------------------------------------------VFGVDRE
NRVMLWSSPAARMLGWEQEEILGAHAFWW----ADGDFERLGEIEQRGRVNGRL----VKWRTKAGTETWAWSS------SSGEMIF---VVTDHVRDTE
MYAEVAQSRNFIERIADCLFAYDVSNRLIYASNACEAMCGYSSDELV-KNPHLWLSLVHPDDLALA-TEPVRTGSGARSEYRIRHRNGTERWVAVHLYPR
FGPDGRVTYLEGLAMDITDRKVHQVELQRLAFTDALTRLPNRQQFEHDLREAVEQAERRNEKLAVFLLDFDGFKYVNDTFGHQFGDATLKAIAERLQQTL
RGRAKVYRMGGDEFTVIQAGIAGEDMRETAARCLDAFREPLQVMGECIPMGISIGAAIYPDHSRDVDTLLRYADISMYAAKEQGGHRLCLYSESGDSAIH
NRLLLHNALAKAFDRGEFSLDYQPIFDVRRGVWVGAEALLRWNSPELGFVPPAVFVPFAEQWGMMQQIGAWVLETACETAARWQKHNLR-LRVSVNVSLS
QMADPRFLDGVADALRRAQLPPDHLQLEVHASLLAQYADLVGDLAHDLNRMGVSVAIDDFGHREAVLAALSAGSYDAIKLHPSLLSMAPEGERQERLMAG
VVRLAHDLGMRAIAEGVERREQEMLLARTGCDEMQGFWKARPASAEDLADWSRNVT----
>tr|A3IK67|A3IK67_9CHRO Uncharacterized protein OS=Cyanothece sp. CCY0110 GN=CY0110_03269 PE=4 SV=1
-------------------IWLETSAKVIPNQDTGEIEEIFC-TSRE---------------VTK--RKQN-QEYSKSYQQPHTFILDNLPDLVTTHTPE
GIYQYVSQVSHQLLGYFPKSLINQP---IASFSHPQDCALIKQFYQELQQKKSLASVTYRMVHKKGHYLWIETVGKAIVHQTGEIKEILCVSRDITKRKQ
IEEALIQAEKIFEKSNQGIFQLSPEGYFIDVNPALAQLYGYDSPDLLDNTNQLYVE----VNNYDHILNLLKTDGEIINPSQIYRKNREIINIEETIWGI
YDQYGKVLYYQGTVQKFENKICQKEESTGINLRDPVTNLPNRQWFYEHLQSIVLDSLNFPNNSLGIVIIHVDSLQLLHESLNITQDNNLLIQITKRLQSK
LRPKILARLEEDEFVLLVRNQSIQEIILIAKQILNIKDHSFDINNNKVFININIGINFNNVDYKKPESMIKDARLAMYQAKAEKKENYAIFNPKIKADAL
ARIQLETDLRQAIKHKKLSLYYQPIVELNTGYLSGFEALVRWQHPLKGNISPVEFIPIAEEIGLISYLGWWVLEQACYQLQIWQNLNTKQLVINVNVSAE
QLKEENWHERLNYLLQNTGIEGTQLKLEITESCLLETVQHETQRVGQLKNLGLGLCIDDFGTGYSSLSRLHEFPIDTLKIDRSFISKLG--ISDKAIVLM
IINLAHTLGMNVVAEGIETREQFNQLQGLNCELGQGFFFAQPMTSEQATHWVMQE-----
>tr|K9SNN4|K9SNN4_9SYNE PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Synechococcus sp. PCC 7502 GN=Syn7502_00027 PE=4 SV=1
-------------------IWVRLTISLIRNIDNSPHF-FIG-ICED---------------ITI--QKQA-QEMSHSA-ELLQVILNNIPQLIFW----
----------------------------------------------------------------------------------------------------
---------------------KDRNSMYLGCNKVFADAMGLTSPQIIGMLPSIFAE----AEKYRADLQIMESDQAQLGIESQPNSNGKEMWVERNKIPI
HNSSGDVIGILGTLQDITLNKQAEISLKTSLSNLQEVQAKLKYDACHDSLTGLYNRFWLIEKLKQIMGKNSLYAVLFIDLDRFKVINDSLGHLVGDELLR
QVAQVTRLGGDEFILLLEDIDDLPIATNLATQIQSQLRLPFNLHNYEIYITASIGITFGIKTYQQPEDILRDADIAMYQAKSKGNGRYEVFNPEILAGLM
ERLSLENDLRRAIANQEFFLDYQPLISLSDQSVCGFEALVRWRHPAKGIISPNRFIPIAEETGLINPLGFWILREACQQAQFWLQAFYQPFSINVNLSPM
QLKQPDLGCQVRQILAETGLPASCLKLEITESCILETDSSQLIILNQLKEMGIKLCIDDFGTGYSSLGRLHEFPIDTLKIDRSFVKRID--SGSTEIIEM
ILALAKGLNMNTVAEGIENLEQLHRLIQLGCHYGQGYLFAQPLDLHASTQFIRKF-----
>tr|A3WJA0|A3WJA0_9GAMM Membrane-anchored signaling protein (PAS,GGDEF,EAL domains) OS=Idiomarina baltica OS145 GN=OS145_04568 PE=4 SV=1
-------------------------------------------------------------------------------------QLDEGATIIYELHKN
FRPAYVSANISHILGYTVQEALSPN--WWFDNVHPEDRALLSAIS--KVEANKTFVHRYRFRSKHGNYIWLRDELRT---FNDDDTKIAGQWTDMSQDLT
W---MRDSKAVTQRELMGFAELNEHDCIVRADNNFRNLVGLTDSLPNAHHILFISPDNESPLLAT--GIEY--------LVEFNRPSQQSLQGLLKISE-
-DKQGS--VRFVTLIDLSAFILERRRLKQIAYLQPLTGLPNIEQLKLDLQNALETAADN-ELVAVLNINIREFHKVNESYGVDDGDRVLQRVAQRFKQAL
PENAFLYCAWGDDFWVLLSGIKEMALQDLMDNLMNSLNKPILIEHKQIKASANIGACTYPLDGLTAAELLSYASSALQRARRQTSACQVIFNQEMASDSQ
SQLLVKQQLHDAIEASQFEIYYQPMCDSS-LQAQGYEALLRWNHEEEGVIAAANFLPLCDTV-TKQKLGTWAIQRIIDDLPSIPVNAEGKRNIAVNVFAE
QLDD-AFVSDMVQFSHQLSETNTHFCFELKEASLIDPSDELRQTLSRLTEAGFSLIIDDFGAGFAGLTYLREFPISAIKVEHDFIKKLDN-ERGYAIVDG
IVELSHRAGIKVHALGVESEQQLKQARALKFDLYQGRYIHPAKPLNELV-----------
>tr|Q5QVI1|Q5QVI1_IDILO Membrane-anchored signaling protein (PAS,GGDEF,EAL doamins) OS=Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) 
-------------------------------------------------------------------------------------YLGNSPTVHYELRAG
FCVDWVSTNCERILGYSTEEVMAPG--WWLNNIHPNDVKTKKTAL--RGFEEEQFVCEYRFRHQQGHYVWVRDEVRR---SSQKPLRFQGSWTNISADYY
D---TNSGKSSEHDVLSGIALLDGRRRVIAIDTPFTDISGLNESACLNSRLELLSADDIDGGFPC--NQSI--------LIVGRDIDKQRYSAILTVREA
ASFPGEA-AYIATLSDVTRMKLQQRQLQKLAFFNDLTGLPNSNSLALDLTRLLDELPSD-RLAAVIVMNVNHFHQVNDQYGHHIGDKILQRLALRLKKAV
PFGTKLYNLGGDEFAVVLNHIVEIDIQNIILEIQAAYEPPFILDQRQVQLAASIGASVYPLDGYDAEKLLAQANLAMNSAKDEHNESSTYFKQELETRSY
DEIQLEEDVRSVLQTGQMQLVYQPVLNMQ-HQVVGVEALLRWEHPDLGSLKPDQFLPQFDANGMLDTLGVWVVEQVIEQIDLWQEQDTVPGKIGINLATE
QISQ-KLYQTVSQFVKKTPKLAAKLEFDLSESSLQEPLPHTLEIIEQLHQLGITLVIDRFGKGVASMLHLKTMPVSKIKIEREFIRDLDTNERSRNLVRA
VIRMTSELGLEVQAVGVENQAQLDTLAEFGCHYWQGKLYMLPQTADTVF-----------
>tr|A1SZT9|A1SZT9_PSYIN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Psychromonas ingrahamii (strain 37) GN=Ping_3317 PE=4 SV=1
----------------------------------------------------------------------KSQSLLEKERVMLRTTADTSRDIIFFRDLE
GLLLSCNKQYEKFTGGLEKDLVGKT---VFAFL-PLDEA-ILAAQRDIIKNNKPYTWKGFFTAHNNECYFFEIKKSPIQDKDGNVQGVATVGRNLTEQLR
MQKRLQITDVVFEHSREALIVTDGDGHIISANDHACFLFGYSKDQLLAEEINLLASDNYNDEYYKNIEQILETESFWQGDITYRTKNGSVYYAWLEVYAV
EHVEENSVDRVYSYTDLTHFQVTDKKISFLSKQDPLTGLRNRISLFSRLEDIITCANYLHSAVAVMLIDIDDFKAINDNYGHNAGDKVLKEVAERLTSCV
SGKDTLGRYGNDQFIIIIDELVNFDAAMVANKIAEQFSRAFLIENSYTNLSASIGISLSPDDGMEASTLFLNAEDAMQRGKSDRSAAFNFYTASLTVGLN
KEFALEQELQQALLSEQFVMYYQPQYDFNNRQIVALEGLLHWHHPKRGILTLERFLSVAEGSHLLVPIGWEIIHKAALQAVIWEKSEIKFGRIAVNLFTI
QLSQISFIAELQTILKETGCSTGQLEFLVDKTVLQHASTDILSNLDNLNKMGITLTITNLGIDANVIDLIHRLGVQNLKISDSQINSGSGILASELQLQC
FKFFARSLSLNVVSDGLDNAEQASFVQE--------------------------------
>tr|A1SWH2|A1SWH2_PSYIN Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Psychromonas ingrahamii (strain 37) GN=Ping_2088 PE=4 SV=1
----------------------------------------------------------------------KSKYLLEKQRRILRATVDISPDMISYKDLK
SRILGGNSPFEKFVGSLEKEVLGKT---VYDFF-PLEQA-IASIKHDVIKNNKVNVQEVISTDDDGERHLLNMKKIPVQDKQGDVQGLISVGRNMTEQRK
TQKRFEIADAVFENSKESLIVTDEDGRIISANDHACIVFGYSKEQLLAQEINILASETHDGAYYKNIEQLLEADGSWQGDITYRTKIGDVCHAWLEAYEV
QHTQENRVERVYSYTDLTHFQVTDKKISFLSKQDPLTGLHNRISLFSRLEDRLTRANYQHSAVAVILVDIDDFKAINNKYGHNGGNQILKEVARRLKNCL
YGKYTLGRFVKDQFIIIIDELASHDAATVARQVTDQFSSAFIIENVHKNITASIGISLSPDDGIEVAPLFLNAEKAKRHSKNSKSTVYNFYTPGLTLGLN
KEFELEKELKQALLSDQLDLYYQPQYDLSKRQIVALQGLLRWHHPKRGILLPEHFLSVAEGSHLLVPIGWKMIRKACLKAVSWENAQFKFGRIAIDLFKI
QLSQISFIAELQTILKETGCSTGQLEFLVDKAILCDASADILSNLDNANKMGFTLTVTNFGMAEDVIDLIDRLGVANLKISDPQIKNASGSLANNAQLKS
ANVFASSLGINILSDTLDNAEQKEFVHK--------------------------------
>tr|K9Y6V8|K9Y6V8_HALP7 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Halothece sp. (strain PCC 7418) GN=PCC7418_0325 PE=4 SV=1
----------------------------------------------------------------------------------------------------
-QIKAVNQSAIAQYGYSEAEFLQMQ---L-SQLYPSSQTPLQN--VSDLVTGEWQNC-----RKDKKLIYVKLTAYPIRTANTN--TVLLLAQDITEYCY
TKIALHHYQSEIEFTPCGILGFNRENYTLAVGNALSQITQITMSEIEGKKISVFSP------YIRELFAPLQEHGYPQ-SYSFQY---HQYTYYLQGYPL
RNQKEQIIGGFLMIKNQTLSKQFEALLDRHAFYDLTTHLPNQIWFLEQLSRHIKTFS--KEGVAVFLLRLERYRIIKYGLGHKFANQLMVAVAKRLKQTL
QLKSDFARVGDAALAMFFPQLTQEKLEQIAQLIHTQLSSAIEIEGEELFCPVSIGVAIYEDSFQDPSALLHAADTAMNAARGEAMSPCVIFHPQLRYSAA
TRVQLETELRRALRLKQLDVFYQPTVTLAEGKLTGFEALVRWQHPQQGLVSPSHFIPLAQELGLIGFIDWWVLAEACEKLAIWQEMIPQTLSMNVNLSEN
MINQVGILERLEQIIQRTGIRPECLKLEVTEGIILEGKTATTGILKQLQAMGVLLSIDDFGTGYSSLQRLHQLPINTLKIDRSFTKRMLNYPEIKQIIKT
IINLAHDLNMEVIAEGIEKEEEWEALKFLNCEYGQGFLFGKPRPEADIRDLILA------
>tr|U4KSC8|U4KSC8_9MOLU Diguanylate phosphodiesterase OS=Acholeplasma brassicae GN=BN85315070 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------FRNWVVEEEHLRFDEAIKQAFLNNDVFH--IRLF-EQKIELTMQIKGSYLVDFT-----HVILAFDYTDFES
LEKTMYEENELLKNLKVGVIEIEVDYKHIYINEYFVDVVSVSKKELLEKTAKDLIPNDYLIEIYLDARK---TNK----PVSFRRITRNGRYCMITAYPS
FNDHMVV-----IYQDVTELKALNDRLAYLATHNTLNAFYNQQGLEEHISK-LK----PVKDAVCFYASISKINSIKAFYGIQFIDKLIQEIGKEFLIYK
KEGFIVANISYHHFILVLLEPKEELIFDVIDHANRSVYKKYHIIDTEINVKQNIGFSRISQEPVNLFELITQAAVANNEASQSEHNVIVKYEESHGFALK
KNINMASKLYQAIENKQIDVYYQKIVDTRTNEVRYIEALARWIDPELGFVSPDEFFELASKSNLIDYLEDYLVQLAIKKFSRYLKKDYPKAILNLNLSPA
ALFKTNFELLVLEKTISSGLKTDDVCIEISENTFIRNTDLCIETINKFKRYGFRIAIDDFGSKYSSLGILDQVPFDILKLDGVFATNIQS-PTILDIVRT
LKDIAHKGQKDIVIEKVETIEISDKFKALGIYIQQGYFYHKPEK----------------
>tr|A0A061AFL2|A0A061AFL2_9MOLU Diguanylate cyclase/Phosphodiesterase (GGDEF & EAL domains) with PAS sensor OS=Acholeplasma oculi GN=Aocu_02630 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------FYVQIKKDPSN--------QILKLDVKDI-IELN-LEGRLVTFRVSGHFNVEGH-----TTYLAFDYREIAY
LQKNLESKGDLLKNLKVGVVEIEIDYEIVYMNEAFEKISKLTLTDVIHKKMSIINPNIFKLNIYQEAYE---NRK----QISFSKASFDQKWYNISVYPS
DHERMVI-----IYSDVHEIKLVNEELEYLATHNRTNGLLNYYGMEKQIQT-IN----HYSHAICFYITINKFEEFETFYDQRTASMAIDLIAYELNQFI
DKRDILVNTKFFHYIMILIDPSEEKVEKVKRFLKESTYKKYPILDHEVIIKKNIGYTRKDDSTIDFIELIRQAQLASNAASKSEHNDIVEYMETFQEETK
TNIVMAQRLNKAIEEKSIDVYFQKIINVEDNEVEYVEALARWIDPVYGFVSPEFFFNLATEAHLIDQLEQYIVYKTFMKFKE-IKKIHPKIKLSMNISPT
SIFNEGFDAYILYQAKQASLNPNDICIEISENTFVRDTNQCVNMIEKLKKYGFMIAIDDFGSKYSSFGILDLIPFDMIKLDGMFANKINQ-TSIQMMVKT
LAEICKHTDKMILIERVEDAVIAQTFKELNVLLQQGYHHHRPEP----------------
>tr|F7PRI6|F7PRI6_9BACT Two-component system chemotaxis family CheB-CheR fusion protein OS=Haloplasma contractile SSD-17B GN=HLPCO_002170 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------YAECIHPDDQEQFKGLVES-VLENNLEEYRVRLF-DKHTYYWITTFGRKINDYT-----YNGVQVDITDLKR
TERKLYESRIIVENTS------DPDGLILYASESYMNLFSKGGNCILGKSIYEIDQTLHNTEMLQKKVS---TTN----EISI--TNIGARWFLWNNDVV
LNDHGQVLYIISVGRDITDIKHANKQLKYESEHDLLTNLYNRRGLMNQLDS-LE----TS-NLAVFFIDIDNFKDINDFYGHEVGDQVIKEVAKKLLVLK
KYNCILGRLSGDEFLLIYKNYPDGTSIKMLSLEEYLLRTKINVNHFNIHLSASIGYAVSPLHTKNISKLIAYSDIAMYQSKLHNKGRTVKFNHDMYKAVE
KKVRLANDLKEAILHDQFKLVYQSVIDHNSGEIKYVETLVRWIHGTKGPISPGEFLHVAEEIGLMQDLDELIINKAIKQYSQFSKQAYKESKLTINVSRS
TLLTTNLADTLTQIVNRYQVKPSHVCIEISESTFVNKVEESREKILRLREKRFIIALDDFGRDYSSLSILDRLDYDLIKTDRHFVKNLNR-ETNVEILKM
IHRIAMLQNKEVIIEGVEEEKQLTLIQELGFSLIQGFYYSIPNH----------------
>tr|F3KYQ9|F3KYQ9_9GAMM Uncharacterized protein OS=gamma proteobacterium IMCC3088 GN=IMCC3088_2012 PE=4 SV=1
-------------------------------------------------------------------------------------------------SRE
GSITLWNKTIEAATGLGADTVFGQN---FLDVLGQSDTQQIRYAFE-AAQSGKSRGIELNIAQRRSVPLATIFSVAPMAGTSPTQRGVIFFGQDITALKQ
ANTEISASATQLQLSLDDVVLHSANAIVWDWNLSSQD------LEFIGQSPADLKSLIHAEAFERAIARHISKDKPLEMHCRLRQKDGGYRWFLLNGQLL
TSGQSGNQHIVGSLLDMNDRIEQEHQIWRMAHLDALTQLPNRSLFNQRFEEKLNGKNKRPEPFSVAILDINDFKQINDARGHVAGDRLLTEFAELLQAHI
TGDDLVARLGGDEFAMLVSPALSEDFQILSDKLINDARQIVYTDSGDRGVQFSLGMARYPEHGISMEDLLRAADTAMYRAKRDKGSRYQLFHAGMDEIRI
QRAQLRDLVAQALENDEFRLMYQPIVALGSGDVVSAEALLRWPSG-PGVAIP-DIISVAEDSGLILKLSEIIFDQAFSLLARLQDLGLK-QTVAVNLSGV
QFRYQDIAAILTNYARAHGADTHRLIIEITESIFLDNIEKTQKTIRELSQHGVRVAIDDFGTGYSSLAYLQKLTVDWIKVDQSFITNINESNPNYQIVNA
IVQMGQALNMGLVAEGVENLAELEQLAEMGCERVQGYYFSKPLSDSDFIAFAS-------
>tr|S5STP4|S5STP4_9CORY Uncharacterized protein OS=Corynebacterium maris DSM 45190 GN=B841_04700 PE=4 SV=1
----------------------------------------------------------------------------------LEALAATIPDALLLIDRH
KRAIPINAAAHDVVFENQDGEILAR---RLREVDGEL---LDETNRPALVREMLVEAYPPAGGTDDDRRFYSVRASPLSLGEVEPGHAVLLYHDSTDEYW
RMRHLRRARALFEYAPQGVATLDDDGVILQANRALGELIGAPAAQLVGRRLDEF--SRD-GAFAGEIEAALADPGTLVQDRDFDSADGWEKRVTLSFRTI
AGGGRGSTLLLVNVVDVTHQHEFYELISHIADHDALTGLINRRRFDADLADILNDGDRDRGAGALLLIDLDRFKAVNDSLGHQAGDDLLVKFATLLQDCV
RATDLVARLGGDEFVVVLPAADRAEATAVGERILDTANRRFRNRPGVLEVTASVGAAMFSEANGSSTDLLVLADQRLYDAKNSGRNRVA----------S
NPLAGEQ-VERILKTDALRLELQPIVDMKTGRVTLAEGLVRVT-PAEGDMSAGELVAVVEKAGLGPELDALVMRRGIGLLPQLQQASP-GFRLSLNLSAQ
SLGSEEVARVIVTELTRRRVPPGSLVLEVTESAPLPDVEAARAFQRRLREHGVAFALDDFGTGFDPYRYLKQLDFDVVKIAGEFVESMTDGGVDLSVVKS
LVRLAEDEGMATVAEYVSAEQIFEAARRLGVTYGQGYHFGASLPPREFIT----------
>tr|Q8NRL0|Q8NRL0_CORGL Diguanylate cyclase/phosphodiesterase domain 2 (EAL) OS=Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / 
----------------------------------------------------------------------------------LEVVAKTLPDALFIVNKN
GTAFPVNAGAKNFVKQSPDGHYSMP---KLQNIDGEP---MDEKESPALVEGVLAKGEVLGEDPDLARRIFEISASPMYLGETEPGHALVIWHDSTNEYY
TMQQLTLAYLLFEKAPQGIAMLDPSGEIVMANRSFGDLVGTTPVRLLGRNLEDF--GVE-EGTMEYVTPVLSDPEAVVHDRSLETLRGKQKNVAMSFSSM
GNVGGRIGTLLVNVVDVTERQELIELVEHLADHDSLTGLVNRRRLESDIEELILKNERDSTDSALLLLDLDYFKEVNDSLGHEAGDQLLIEFAEILKDSV
RDSDIVGRIGGDEFVIVLPDTDRDGAEAIGIRIIELVNQHFKGRGKVLRVSVSIGGTLFSDARAQGVNPFILADQLLYDAKHAGRNRVA----------V
RRFSVEE-LSEILESHSIRLELQPILELETGRVGAAEGLLRIN-LDGTDVPTGQFVQSVEQAGLAPKLDIAVMREGINHIERLRAVCP-TFSLALNLSGY
SLSSAKIREELRAEFRARDLPRGSIRFEITETAPIEDIDAAKEFVQMLKDFGFHIVIDDFGAGHEPYQYLKKFDFSVLKIAGEFIEGMVTNRVDRSIVES
IAQLAKDEEMETVAEFVSSKEILEAVREIGVTYAQGFHIGKSKPIDEFIA----------
>tr|R5T8U7|R5T8U7_9CLOT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Clostridium sp. CAG:75 GN=BN771_00173 PE=4 SV=1
--------------------------------------------------------------ITQ---SRRNLLEAYEAKRDAELISNSIPGGVIKLRMD
FKLLYANDGFYRLAGYSKEEYQINFGDYCDRVLYPADAEMVKRQVKASVENRGLVGFEYRIISKTGDVCWSYVNGCRIDDDNGEPV-YLCIIMDITKRKQ
LEKQFEEVAIIAKFMRETTWTYDIATRVLSRGGNL--DETYSNESILEEQLEFLHP--DDVRFRQALKRREEELGGHRGVYRMKDNHGEYRHMEVASVSV
GDVSDKPVKVYGITRVLDNALADSAESSQAKFEDTLTGMIPYAKFLDKAREMLA-ERTDDKRYALMCADIDEFRKFSHHYGFSISNEILLKFSRVLQKFV
ERGGLCARVDGDYFVAIFPYQDHKTLL---KK-LSRMMHYQDENENQIGFDTTNGLYLVEPTDNELGDMLEKADLARRSIKGIKGNHYAIYTDDLQQERF
REERIIQEILDAMEKQTVEICYLPRIQGDKENVVGCTAVARIQMQDGQYLETDGILHYIERGGRLDKFSYFLLNQVCCSFGARKAKGLKTVPLAIQMTAS
QLSARNALSMIENIVVQNKMDPSDLIIEVHERYFADMTSALQVALEQLCKRGYQIVISRFASHHTALHSLRTIPVKGIKFHAECFMGGKNGEREKTILKN
IVIMAKELGMTVYCGGIHTKLQEEYAREIGCDMLEGEIFYGAMRNNVFEKCF--------
>tr|R5S7Q5|R5S7Q5_9CLOT Diguanylate cyclase/phosphodiesterase OS=Clostridium sp. CAG:122 GN=BN479_00029 PE=4 SV=1
--------------------------------------------------------------ITK---SRNNVENMFKAKHEIDVIANSIPGGVLKIRMD
MKILYANDGYYMLSGYSRAEFHINFGDYCDKIIYPADMKMVKSVFGTTVENNGLLGFEHRIVGKTGHTKWLYVNGRKIDDESGEDV-YLCVLMDVTSRKS
MEAEFEENIYVSEYLKETMWTYDINNKTFTRSGSL--GESFSKENFLRTEMELFHP--DDAIFEKNVKNRIENIGSSRYIYRIRDNSSMFRNVEICAVSV
SDGDDKPDKIYTVTRLVDNAEEISSRSAQAQAEDNITSLMPYASFMNKAEKILS-ERKEKEHYALVCADINEFRKFSHHYGFSISNRILEEFSKTLLNNL
AKEGVCSRVDGDYFVLLTKYESHKELL---RM-MSEMVRARNVEDVNIEFGTTTGIYLVQESDCELLEMLEKADMARRSIKGLRGNHYAIYTDDLKSEQF
KEEETISEVYDAVRNNDIEICYMPRIKGDRENIVGCKAVPRVQLKDGHVLESDELTRLIERGGKLSSFALATLSTVCCSVGAWKKLGNKIVPFSIEMTAS
ELSIHNVVKKIDDIVKKNGLEPKDVIIEIQERYLADMTTVLEMAIEKLCGRGYNVVISRFGTDHTAIHSIRKLNVTGIKFHGEYFNEYMTSEKECIILSK
TVEMAKSLGLTVTCGGIHTPMHEEFAKKIGCEMFEGDMYYGAVRANVFEKCF--------
>tr|R6M0C4|R6M0C4_9CLOT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Clostridium sp. CAG:253 GN=BN565_01552 PE=4 SV=1
--------------------------------------------------------------VTK---SKNNVESVFKAKHEIDVIANSIPGGVIKIRMD
MKILYANDGYFMLSGYSRAEFHINFGDYCDRIIHPSDMKMVMSTFGTTVENHGLLGFEHRLLGKMGHTKWVYVNGRKIDDESGDDV-YLCVLMDITSRKI
MEAEFEENAYVSEYLKEAMWTYDINEKKFSMSGSL--GEAFSEEKFLNTDIELFHP--DDVIFEKRIKERVEKAGSSRYIYRIRDNSALFRNVEICAVSV
SDGGEKPDKIYSVARIVDMVDGISTVSAQAKAEDNITSLMPYASFMNAAEKILS-GRKDDEHYALVCADINEFRKFSHNYGFSISNRILEEFSKTLLANL
AQDGVCSRVDGDYFVVLLKYEHHKDLL---KM-MSSMVKSRNVDEVNIEFGTTTGIYLVQETDCELLEMLEKADMARRSIKGLRGNHYAIYTEDLKSEQF
KEEDVIEQIHDAVRNHDIEICYMPRICGDKDNIVGCKAVPRVQLKDGQVLESDDLMRLIERGGKLNSFALATLSLVCCSVGAWKKMGNKIVPFSIEMTAS
ELSDKNIVKKIDDIVKQNGIEPENVIIEIQERYLADMTTVLEMAIEELCARGYKVIISRFGTDHTAVHSIRKLSVTGIKFHGEYFNKYMTSKKECIILSK
TVEMAKSLGLTVTCGGIHTPMQEEFAKKIGCEMFEGDMYYGAVRSNVFEKCF--------
>tr|R7K105|R7K105_9CLOT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Clostridium sp. CAG:277 GN=BN584_00160 PE=4 SV=1
--------------------------------------------------------------ISG---SKRHLQDVYNAKRELDLIANSIPGGVIKVRLD
FKIMYANDGFFRLAGYSRSEYSMQFHNDTSELVYPEDMDMVSMVIRQAIENRGPLAMEYRIMAKSGEIRWSYINGTRIDDDNGQPV-YLCVIVDITARKQ
AEAELADNNVITKMLRETIWTYDMDAHVLHRDGDL--GGTYSPETILEGNIAIIHP--DDVKFIQMRNSWDADAGMHQDIFRVLNGNGAYQRVQISTSTE
K-KDGQGSVVYGLTRLLLDNEQNAVKSARAKTEDTITGLLPYASFLRKAEKILA-SRREDSHYALICADINEFQSFSHHYGFYVSNRILKAFSDVLLNHL
TKDGMCARVDGDYFVVLFQYGTHKELV---NA-MSAVVRHQQVAEDNIDFGSTVGVYLIQQEDQELLEMLEKADLARRSIKGLRGNHYAIYTEDMEEQLS
REDEMVGEIRRAMDEHSVEISYLPRIRGDKDHVIGCKAIPRILMKDGQYFEYTQIMHLMERGAQLEEFSFYLLQEVADNIGAWKAKGNQVIPVSLEMTAS
QLSTRHAVERIHNIVEQNKLEPVDFIFEIPERFFADATTAFEVAIRNLTNLGYQVVISRFGADHTAVNSMRRLPVTGIKFHGEYFSEHMINEKDTVIFRK
TVEMAKEMGLTVTCGGIHTRLQEEYAKKIGCDVFEGVIYYGAMKNVVFEKCF--------
>tr|R6ECD6|R6ECD6_9CLOT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Clostridium sp. CAG:230 GN=BN547_01955 PE=4 SV=1
--------------------------------------------------------------VTQ---QRRTLAEVYDAKRQVDLITNNVPGGVIKIRID
FSILYSNDGFYRLAGYSRSEYFSLFGNHCDKVIYDQDAERVAHMIRAAVDNGGTISFEYRIIAKNGEVRWSYVNGCRVDDLNGEVV-YLCIIMDITAKKK
LEQKMADGLYLLEYMKETEWTYHIKSKKLYRNGYI--DGTYSRERELQNTLPTVHP--DDLALCAFFDERMHEIGKAKGVFKVKDSKGNYHPTEVYAITV
GAETGMPERIYGETRFLDDRSFVVSQMAREKVKDVVTGSMPYQEWIERTSSILK-NNK-EEKYGILCCDIDGFQRLTYHYGISIGNELLTSFAKLLCKHM
AYDNMCSRISGDYFVVFFKYEKHGELL---KR-VSHMLRMQKEKLSYNTYGTTSGIYLVKPGEQDLDKMLECADLARRSIKGTRGNHYSIYTEELQRNQF
LEEEVISEIGTAMMEQSIEICYLPRIYKNRDNVIGCKAIPQIQMQNGSYLSLEDLRRYIDRSEEIQQLFFYVLSNVCCSQGVWKSKGYKIKPISIDITAS
QLCLQNAVEKIDETIRENNLEPKDIILEMQEHCFKDMTTNLQMALEDLDRRGYKVFISHFGSDHTAIHSLRSLPIAGIKFHGEYFKQDISDKKEHIILKK
IVEMVKEMDLTVACGGIHTKLQEDIARSIGCDILEGEIYYGAVRNEVYEKCF--------
>tr|R6VGQ8|R6VGQ8_9FIRM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Roseburia sp. CAG:380 GN=BN635_00298 PE=4 SV=1
--------------------------------------------------------------ISG---SKRHLQDVYNAKRELDLIANSIPGGVIKVRLD
FKILYANDGFFRLAGYSRSEYSMQFHNDTSKLVYPEDLDMVTSLIRQAIENRGPLAVEYRIMAKSGEIRWSYINGTRIDDDDGKPV-YLCVIVDITARKQ
AEAELADNNVVTSMLKETIWTYDLENQVLRRDGDL--GESYSPESILEGKLTIIHP--DDVKFMEMRNFWIEQEGRYQDVFRVINSHGAYHRMRISTCTE
K-RPGKGAVVYGLTRLLSDGEQTALKSARAKTEDTITGLLPYASFLRKAEKILA-NRREDSHYALICADINEFQSFSHHYGFYVSNRILKAFSDVLLNHL
TKDGMCARVDGDYFVVLFQYGSHKELV---RA-MSAVVRHQQEVEDNIDFGSTVGVYLIQQEDHELLEMLEKADLARRSIKGLRGNHYAIYTEDMEQQLS
REDEMAGEIRRAMDERTVEISYLPRIRGDKDHVIGCKAIPRILMKDGQYFEYTQIMHLMERGTHLEEFSFYLLQEVADNIGAWKAKGNTVIPVSLEMTAS
QLSTRHAVERIHNIVERNNLEPEDFIFEIPERFFADATTAFEVAIRNLTNLGYRVIISRFGADHTAVNSMRRLPVTGIKFHGEYFSEHMINEKDTVVFQK
TVEMAKEMGLTVTCGGIHTRLQEEYAKKIGCDVFEGVIYYGAMKNVVFEKCF--------
>tr|R7HT59|R7HT59_9CLOT MorA OS=Clostridium sp. CAG:411 GN=BN648_01449 PE=4 SV=1
--------------------------------------------------------------ITS---MKVSYQDLAKSKQELDVISNSVPGGVAKIRAD
FKLLYANNTYFEIAGYSRLEYEEKFDNICIGLVLPEDATKLQEKVQKALREHSPFTAEYRIMHKSGQIRWSHLHATLMEDTDGSPI-FLCVIINNTIQKQ
YQRELEFFHILAELTNERLWEYDVRTNVMQRSGKL--DASFSLDETIPDQDKVIHV--DDQTFLNAFQFSRNTKKNIKLEIRMKNNIGIYIWYRMQGIVM
YDDTGNPYQVIGKTIDIDASKQIDQKNQKRNYYDRLTGLYSLPAFILEGETQMD--QKQDKKIAIVYFDINSFRIFNANYGFTIGNKILKYFARVLEEEK
RENEMCCHVEKDEFVCMLYYDTAQDLA---LR-FTDMKTHFSANEDYFRLNFTCGVYFSTGEREDLASMIDKANYARKATKGVTVSHYAVYNGDTEKKAK
KQLAIEASIEQAMKNEEIVPFFQPQYSLHTEQMVGIEALARWKTTDGTSLLPEDFFPVLEENGFIVELDFYIIEQTLKIFKSWMEKGLPLFPVSFNISGS
HLLTTNFVERLVALMTQYSVPINYLELEISEKVFVTSPETTVFLVQELKDLGFKIILDDFGREFSAINSLKDLDIDGVKLDTAFFNGKIRKEKERIIFKK
IIEMAKELKLSVSSEGVETTLQAEQLKDFGCDFAQGFLFHNPMSATEFEEYI--------
>tr|R7AFY9|R7AFY9_9FIRM Diguanylate cyclase/phosphodiesterase OS=Ruminococcus sp. CAG:379 GN=BN633_00569 PE=4 SV=1
--------------------------------------------------------------ISH---IKRLQAKFNETEMELEALIQNLPGSVSIVEIE
MHLLHATEDYFHQFGYTREEYM---GGILGKLFYPQDLPILNQHIAAIARGEKTIFMQVRVIRKDQSLMWVDVRGQFLRIQNGNPL-FYLATFDITKAKQ
RDEELRLQTLIAEHTDELFYDYDVKHDTMNLPLNP--VRQGKIPAVIPGIPKVVHP--EDYRFLRELMSCLTEEKKTSIEVRMRPGAEDYEWYRLVCVCS
ANEQGEIVRLFGRQTSVDNLRR----IERLSTTDPVTGLLNRVAFKERSALYLE-EADTNACYAFVYSDFNDFSYVNDNFGYDSGNTMLYEFGSIISSSP
A-TVFGSRINSDYFLCLMKTDTRDELE---RL-VRERDALFVQKYPASEIQVATGISFIDPRHFEVTEEMDNANLARRKAKTGKDDLCCIYYEALRTARA
REKAIAAELHGAIASRTVELFLQPKFMMDDLRIIGAEALVRWRNPDGTYRMPSEFIDILEKVGYIVELDFFMYEEVLRSLRQWQDNGMPLVPISVNFSRL
HNNYPNFVDRVIGLAKKYQIDSRYIEVEVTESAFASDAQQMERNMCRLREVGFSIDIDDFGKGYSSLSLLMGSPIDVVKVDKAFVDSIELSEKHREYIKR
MCMLIQATEKEIVFEGVENRKQADFLCACGFKKAQGWLLDKAVPVSVFEQKY--------
>tr|R6CBY7|R6CBY7_9FIRM Diguanylate cyclase/phosphodiesterase OS=Ruminococcus sp. CAG:579 GN=BN718_00004 PE=4 SV=1
--------------------------------------------------------------NSD---HAALKRKYESAEKEMDAIAESVSDGLVMVRID
PEMVKASDEYYRIIGMDKDSCCGLMECVKTKLLFEQDLPI----------------------CRSGERAWLRLRARYLDPPEGEAM-LYCAIADITENKM
AEYRLKKQGMIADNTEEKFFEYNAERDELSITAGV--MKQFGSNGIMRNTAGLIHP--DDIVFYKTWENALASPQKGTADFRCLIKKGTYRWYRMPYISV
ENENGEITGVYGMFFNIDHVKT----IERLSTTDAVTGLLNRGAFEKAAAASLKELFPTGDCFAVCYSDINDFSYVNENFGYEAGDKMLADFADIIMNCG
V-CVAGCRIYSDYFVSLYRAKDREKLI---DK-IGERNRKFSEKYPLSNIQVSCGLYFMRAADEDINTAIDNANLARRSVKGSTDIPGGIYAERMRIKRS
HDQAIASEIFNAIKTGAIELFLQPKFNMKTRGLIGSEALARWRNADGSYKLPYEFIDVLENVGYITQLDFYIYEQVLINLAKWKREGRPLYPVSVNFSRK
HNIYPNFVSKIAELADRYDVEKSLIEIEVTESCFTQDVKNLFTNMKKLREHGFKIDIDDFGMGYSSLSVLMDAPVDIVKVDKVFIDNIENNEKSREYIDR
ICNLIQTASKEIIFEGVETEKQAEILCSSGHKMAQGWLFDKAIPVAEFEKKY--------
>tr|F1Z3U4|F1Z3U4_9SPHN Response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Novosphingobium nitrogenifigens DSM 19370 GN=Y88_1813 PE=4 SV=1
---------------------------------------------------------------------------------------------VLCIGPD
GCITYANDSFLRCTGHSFPDISGRH---YSCVVDLEDMDFLPDAANAGAGDG-ERAGPIPLIRKDKETFWSYGTLQPMT-GEGQDGTCLACAFDGPGR--
---------MLFEQAAMHFLIYAIDGALMAANARFLEAFHYRAEDVIGQDHAIFLSEAYAVSEYANFWKSFRLGASHSHDVRFGRHRRE-VWIDAVYFTV
ADSRGTPVKVVQIGRDLTLQKQAEQDRARAESIDCLTGLENRTSFMRSVQKYFNPVT-NCTPFLLAVIDINRFSAINTAYGNEAGDAILWVVAKRLKSAL
RSHDISSRIDSDMFGVFIESLPPDGHKTVIERILREISAPIEFGDEQIALTASAGVVTGDGREAGEDDILACAQAALKAAKTLDLNAYRLFDIEFAHAAK
RRMTIGRDLDSAMQAETITLHYQPVVSFTDKRPVGYEALARWTHDTMGPIAPPEFISIAEETGAIHCLGKYLFDKAVKFASTLDD----NLWVAINVSPI
QLQRKEFSTGAMDIVRRYGIHPHRIDIEITESASLDMSRTVQDNLRNLRDFGFSISLDDFGTGFSSLSQLLNLRADRIKIDQSFTRGCLQSPEKVGIIRS
ILGLSAAMGMQVVAEGIETPEISDLLQDLGCDYGQGYLFGKPMDL---------------
>tr|M5A150|M5A150_9ACTN Uncharacterized protein OS=Ilumatobacter coccineus YM16-304 GN=YM304_21630 PE=4 SV=1
---------------------------------------------------------------------AALDASLRRAE-LFERGFEAASVGLQIVDED
GVFLRVNRSFATMIGRKREELVGLH--WT-AVTHPDDIA-MHEDVRRRLDRGAMYRDVKRYVTADGSIKFGDITITSVTGKTDMPFR-LVQVVDVTEQIR
SLNDLAAAESLVEPAPDAVLRIGADGIVADANASAERIFEFDAS--VGAPVSLLP--AVFADEVAAMVRTVMVTGAQDQRQRLRLGDGTSRWFLTRIVAE
-DSTGTSPTAHVVMSDITQMVEHEERLSAMARVDAVTGVANRVALYERLEVALAALGESDTCVAVAAIGLDHFKTVNDSFGHAFGDEAIRLFARAVDATL
GPDDMFGRLGGDEFLLVLDNQPTDDAKRVVERLVDMI-TPLELDGRTISLSASLGLVVVT-SADDVDDVIEMADSALLEAKRTGRGRLKVAGASSGDGAS
LRVQLL-DLLDADSRGEFELLYQPIIGAD-GRVRSVEALIRWNHPDRGQLTPDHFIDALIHSGRIEGVGRWVVSTAVRQIEEWDAIGLGGLSININVSPG
ELAHPGFCSHLRTTIAESSIDPSRIRIEITELALAGT-FVPTAMLDDLSNIGARIVLDDFGTGVSSLSHLRVKSLSGIKIDKSFLRHAADNIVDRGIVEG
MIALAHNIGVDVTVEGVETRDQAHWLASTGCEAMQGWLFSRAVSATDVP-----------
>tr|A0A0D6AXY6|A0A0D6AXY6_RHOSU Diguanylate cyclase OS=Rhodovulum sulfidophilum GN=NHU_00594 PE=4 SV=1
----------------------------------------------------------------------------------------------------
----------------------------------------------------TPFEMRLRVCRPEGGFRSVLVASLPFSREDGTVV-WYGNVFDITDRLD
AERRAAEAARVHERLSSVAMIAQADGSIPYTTPKFEDIMGLTREEIDVRLPRLLDSIEDS----------ARDLTLWSQRFRIRHPERGLIWLSGASAPR
RQEDGTIL-WAGALHDVTGDVQREAENERQALHDGLTGLPNRRFYDRVLSSRIEAARAGQPDCVLIRIDLDHFKYVNDTLGHEAGDRVLIRVAEVLRQML
RAVDFVARIGGDEFSILLGDMNQDNARELIERVQGALSRPLTYEGRLCRFGASFGIAHTGDITELGAELQLFADAALYRAKEGGRNRMEFFTAELHRNIL
NDRRIAVELHEALERDEFEPFFQPQIAAEDGRLVGAETLLRWRHPEKGLLSPDDFMHVAEQLRIVSEIDRIMMRKTRSALARWQDQGLVLPKISFNVSSG
RMHDPDVVSLAR-SMAG---GGTRVTFELLESILVEEESDAFRHLDQIREAGIDIEIDDFGSGHASIIGVMEIAPKALKIDRRIVRPVACDMRSRNLVRA
IIEIAETLGIATVAEGVETEEQAKILRGVGCQVLQGYLFSHPLDEGDFLAFTRA------
>tr|K2PQU1|K2PQU1_9THEM Cyclic diguanylate phosphodiesterase (EAL) domain protein OS=Thermosipho africanus H17ap60334 GN=H17ap60334_02418 PE=4 SV=1
----------------------------------------------------------------------------------KENLILNISDGIILVDKN
NYVLDLNKPAQKIIGKEFNQIINRK---L------EDNF----------K-------NGQIIEKNGKYYSIEV-----IDEKGSIY----YFRDVTKEMK
YSKRQEIANNLFNNIPDPLALVTPSGKIVDCNSAFTKTFGYKKLENIENVPDYLKEES-------KILILILKKGHVSYETVRKSKSGKNIFVRIYASKF
--EIENQTFIYIIYSDISKEKKLSQQISNLIEKDPLTKTFNKVYIIKRLKNLKP-----LLYHSLIFIDIKDFQRINSLKGNVFGDKVLKIVANKLKECT
--NYIISRAHADEFWILAEELDIKKAYSKNKELILHIDNCKNIKVDDTSLKFHIGTYIFKND-ENIDEVIRKTSLSLSRSKDE--DKIITYSKEIEDEIR
KELEKEIQIKKAIEKGEFIPFFQPI-ATHNMEIVGAEALIRWVK-DGKVIPPFEFLDFLEKTGLIEQASKQIFENVCKLLSK--TKKL--KFVDVNISPI
QLKNTNFSKDYLKILEKYNIQSSQITIEITENLFIDYNDIVRENLNLLKSEGFKLCLDDFGTGYSSLNYLRNIPFDIIKIDREFISNID-DEKNLNLLKA
IYSIAESFKMGAIPEGVENEKQLEILTMIGFRLFQGYYFGKPMPESEFLSILS-------
>tr|A6LL12|A6LL12_THEM4 Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Thermosipho melanesiensis (strain BI429 / DSM 12029) GN=Tmel_07
----------------------------------------------------------------------------------KQKLLMTLSDGIILVDKK
GYVMDLNETASKIIRLDFNNIVNKT---L------SKNF----------D-------EGEIIFQNESYYMVKK-----IPEDGTAY----FFRDVTKEME
FSKKHNIADTLFKNIPDGVAIITPKGKIIDCNKQFTKLFGLKRLENLETVPPLLKQES-------KLLILVLKNGYATYETIRRSKDGKEIYVKIKAIKF
--EIDDKVFIYTIYTDISKEKTLSEQLTKLIEKDPLTNTYNKTYITKQIKYLSN-----IFFHSLIFVDIKDFKWINSIKGYKYGNELLRNIAAKLMDKI
--DAIISRAQNDEFWILIKDIDIQKAYQKNKKLIEKIKQKS-----TFEQKFYIGSHLFKNS-EDLEEIIRKTTLALSKSKDV--EMEIVYSKEMEEQVI
KEVTKEIQIKQAIKNRDFIPFLQPI-SKENMEIVGAEMLLRWEK-EGKIIPPSDFLDYIERSGQIHEISLQVFEKTMEFLKK--HPNL--KFIDVNISPI
QLKDKNFFDEYLKIIEKFNISPKKIAFEITENLFLSYDEQVKENISKIKKEGIKLCLDDFGTGYSSLSYLRNLPFDMLKIDREFIKNID-NERNTNLLKA
IYSICETFNLTPIPEGVETVKQLEILSMIGFKLFQGYYFGKPMSLEEFEKIVS-------
>tr|A7HKA4|A7HKA4_FERNB Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S) OS=Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 
----------------------------------------------------------------------------------LIKSIEQANTIV-LLDED
DNVLYINEAGLKFIGLSRDEIIGKK---N------EEIK----------T-------SNHLIEKNGKTYRFSL-----QENAGKVL----IINDITSGNK
SFSSIDILSSLFDNVPDGVVIIKEDGTILKCNRQFLEMFGYSKDEVIGEVPEDLSNEP-------KLLREVKNQKTLRVETIRKRKDGKKIEVRLTVAKI
--KNNAEDLIYAFYTDITSEKEALNIVRNTLQKDMLTGLYTRSYFLRRLTSLSEFS-LIGDHHGIILIDIDNFSQINILKNHAFGDEILRQVALRIKN--
--GDIISRPYADEFWIIIEKAGKQQAREVINNIVSKIFNEYYIDGEVIELKFSSGLHVFSII-DNADEVMRKANLALKRAKSSK-DKIIFYNILIDNELQ
EKSTKERDLREAFHNRELKIFLQPI-CKYDKTIVGAEALLRWVKKDGSVLPPIEFIQLLEENGMIVSVGEEILRQVCEVLSE--NNEL--KFIDINVSPV
QLRDEKMAERFFNIVSSYEIDPSKIVIEITENILIDMNDIVKNNIDKLLKYGFELCIDDFGTGYSSLAYLTLLPLKKIKIDKSFVFRLPDDRKSIKLLEA
IYNIAKAFQLEAIPEGVENEKQLEILSMIGYKLFQGFFFGKPVPTYEFLKRLT-------
>tr|H9UAX0|H9UAX0_FERPD PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein OS=Fervidobacterium pennivorans (strain DSM 9078 / Ven5)
----------------------------------------------------------------------------------RYSAYEHAEEGIVIDKRS
ERVIDINEKAAHLLNLDRKAIVGRK---D------ENVE----------R-------SGEIVFEANKYLKIST-----IENGTLLV----VVKDVTAEII
SKKDIEKVQTLFENIPDGAVILDEKGKVIECNKQFLSMFGYTKEEVLGKAPDDLKNEP-------EKLQKAIEQKASRVETIRKRKDGSLIEVRVTVSTM
--ETGEETFMQAVYTDLKAEREAMNRVRNILQKDTLTGLYTRQYFIRKLSSVIEFS-STNDYNAVIAINIRGFSLFNSTRGHNFGDDLLREISRRLKS--
--GDTIARPYADEFWILLEKVGKRQAKVTVANIVGKLESEYNINGEILDIRFSTGIYIFTSM-DSPEDVLRKLNLALARAKTST-DGVVYYSALIDNELQ
ELAARERELKEAVYNGELKIFLQPI-CNSYSEVVGAEALLRWVKKDGSVVPPMDFIRVIEENGMIITVGEEVLRQVCEFILDN-DTSI--GFIDVNVSPV
QLRYPNMADRFIDIISAHKIDPRKIVIEFTENILIEMNQIVKDNIEKLLNFGCQLCIDDFGTGYSSLSYLTLLPLNKIKIDRSFVSRIPEDSRSVKLLEA
IFNIARSFNLDAIPEGVENEKQLEVLSMIGYRLFQDYYFGKPMPVEDFAKILR-------
>tr|L8D999|L8D999_9GAMM Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) OS=Pseudoalteromonas luteoviolacea B = ATCC 29581 GN=PALB_35110 PE=4 SV=1
-----------------------------------------------------------------------------------DEIQKIAKVGGWQYDLQ
NGELYWSDETYRIYGYPVGSEIDPSK-GISHYL-GEDQQTIANDFDALINQQKPYTRELRFIDAKGKFKWVRTSGRL-RTQNGKALYAYGAFEDITILKD
LIDAHRYLATVIDNLNDVIVTISEDGIILTANSKLKAVFGYEPHELIGQNVCLMPSP------YKEMHQSYLKTGKAQGELPAIKKNNEIFPIELALTEV
K--QGEQRIFIGIVKDISERKTAEDKLYKLAYFSPLTNLPNAFSFEEQITKHIEKVRLVNGRLLVIKIDIDNFSKINLAHSRKAGDYAISMIADRLRLFS
NDYFELYHLRGDIFYLVSRNSQQTECDSLATQIKQQLANEVIIEGMPYRLSASIVSAIIDGEYASVEVLYELLAMAVKRLKLGGGNQHTIVDNHAHQYLE
RRARIKSMLPSALLNNEFFLVLQPQFDIH-KQYTSSEVLIRWNSKEFGFISPGEFIEIAEESGDIIAIGYWILEQVAKLLSLQ----QPKGRLAINISAK
QLAKPEFEETLFHYFTHYNVSLKKIILEVTETTLVQDLEQIREKLKRLTALGIEFSIDDFGTGYSSLSYLQNLGIHEIKIDKSFIDEIDGV-TPVPIVDS
IIQLANSLGARVVAEGVENQTQFDYLVHKECDVIQGYLLSKPLPIEDWVK----------
>tr|K2KIW6|K2KIW6_9GAMM Diguanylate cyclase OS=Gallaecimonas xiamenensis 3-C-1 GN=B3C1_03230 PE=4 SV=1
------------------------------------------------------------------------EAQQKAASERLALATRAGKIGIWEYVPH
QGLLTWDSLMYSIYRLEPDESQDLMARWR-GRVLAEDLPDLLTRFEDTLNLGQHLDSLFRIRLPDGALRYIRTMAEPQLDEAGMVKRVVGCNWDVTDFKR
SEQALFEEKVTLGSIGDAVVCTDAAGRVSYFNHVAEELLGWPLDEAMGWDFRIFYDERTDNALPNPVLQCIEENSHPAQDMVMVNRYGKRFDIISSAAPV
RDSDGLPQGAVMVFQDMTRTRALQRELSHAAAHDALTGLLNRAQFEQSLERCIDKVHRSGKVAQFCFFDLDSFKILNDSAGHSAGDALLVELGQQWRQLI
RSDDVLARLGGDEFGLLLEHCNQDKARQIAEEMLAAAKLNFRWEGQDYDVSACVGIASITPATQSLAEVMSHADVACYAAKSSGRAKVCIYNGDDAQLNH
QELMMASKLKAAIQEEKFMLYCQGME-AFNGDERFVELLLRLKSDDGGVIGPAAFIPAAERYDLMEHLDLWVLDQVLRQAQLLADAKVD--CYFVNLSAN
SLSSELFAKQLLDKLTNSPLGPSRVCFEITETALINQMSNATRLVQQIRTIGGRIAIDDFGSGLSSFAYLRHFQVDFIKIDGCFVQSAAHNPLDRTIISS
ISNIAHKMQAQSIAEWVEDDVTATLLHKMGLDYGQGFYFGRPAPLAEFLR----------
>tr|I8I382|I8I382_9GAMM Uncharacterized protein OS=Hydrocarboniphaga effusa AP103 GN=WQQ_05830 PE=4 SV=1
---------------------------------------------------------------------------------SYREALEVSATLGAVLDEH
GHLLEVNPTLLTFLGSNAEALLAAG-EWTRLLRQEMDLHLIGDHAAP------ARVSLSRWQTAQGPRLIVEWRLEPEPGPPGDFLH---LVR-------
---------TGLRIMGEGVIATDALGSIDLINPAAERLTGWSQAEALGLGHSVLKSQGQA-VAASPVWRCLRREGETLIERQLLGRDGRRLRVRLTCARL
-VEDGVVLGALLLLQDITEQSLLVAELAYRSAHDSLTGLYNRGEFERRLSAALALAKSGEATHWLALIDIDQFKVINDTLGHYAGDELLRRLAPVLRSQL
RSDDAVARLGGDEFGVLIRAGDATEARRIIDLLLDAVRGRFAWDERSYSVTVSVGVAEVSAQSEDMARVFANADAACFAAKDAGRDRSRWHGDADIRQRH
AEMSMVGRIGKALDEQQFLLFYEDVIPASGTQVHYRELLVRMLDDDGTLVQPAAFIAAAERYYLMTALDRWVVDHACAGIARLPADG---VIYAINVSGM
SLSDDQFLAFVIGCIERYGVAPERICFEITETAAISHLSEAMSFINRLADLGCRFALDDFGVGMASFSYLKTLPVHFVKIDGSFVRTMHSSAVDRSMVEA
INRLGHDMGLRTIAEHVEDAQTLCALGALGVDWVQGKAIAPGRPFNE-------------
>tr|I1AVV2|I1AVV2_9RHOB Diguanylate cyclase/phosphodiesterase OS=Citreicella sp. 357 GN=C357_12891 PE=4 SV=1
----------------------------------------------------------------------------------------------------
---------------------------------------------------------------THGGTRWVTSTAQPVGIENG-VVRWFGFMFDSTEQMQ
AEQRAAQASVMADNAPGAIVEFRIKVRFLYCSPRLAELMGLPLDPLRGRTVYA----NVPPEDLDGVMAAVKDTGDGPGTFRHRVNHPGERWLRVSLSPN
GDSEG-IIG-FGSAIDVTDDVHRERENERQAMHDGLTGLPNRRSYDREIESRRSAAQ---KAGTIIRVDLDYFKSVNDTLGHEAGDALLQRVADVLRARI
GPEDFAARVGGDEFSILPDPSLPEAVCALVETIRKQLAEPFFFEGRQCRFGASFGIARSDDMAADATDLPVFADAALYRAKNLGRNRLEIFTPELRQTIL
GERRLAIDLHEALERDEFEPWFQPQFSAQGEQLVGVETLLRWRCPDGRILTPESFMQVAEHLRIVPEIDRIMMLKARDALDFWQADGVFIPKISFNVSSG
RMRDPDVVALGRQVA--TG--KTRVTFELLESILVEEESDAFRHLDLVRESGIDIEIDDFGSGHASIIGLMEISPTALKIDKRIVLPVARDVRSRNLVRA
IIEIADTLGIATVAEGVETIEQVHILRDMGCDVLQGFHYAPALDMVT-------------
>tr|B8EEU6|B8EEU6_SHEB2 Anthranilate phosphoribosyltransferase OS=Shewanella baltica (strain OS223) GN=Sbal223_2204 PE=3 SV=1
---------------------------------------------------------------------KKENKHLRTAERTWQGMLAASPDGILIIGSD
GIIEQANLLACAQLGIEYQEVSGRS---YGQLVHLDNIK-------EAISTGKAIRWDDSLDHS-----HLGLTAIPIDDGSGVI----LICRDLTQQMH
IAARLK---TLIETLPDLIWLMDTNGCLLNCNSKFENLVGLAESQLKGHSIDILPQTLQDN-ATQVLWRKAAHSREWFT----YAADKHREYVEIILTPF
IDYLGDIKGIMCVARDVTAFRLNEEELERQLYTDKLTGLPSRQAQ---LEHIEALA-ANNSTFSIIGISLNRYSRVISNFGLAMSELLIIKAVSAIAEVI
PEGCQFGSSTDIRFSIVVANVVDNILADIAKKIIDRMCIPLKIDDATVFVNISIGIASYPTHGNSTDLVIRNTYIALTEAEQIDGSAMHFFESSMLTKVQ
QLQWLDQNLRLAFEKDQFELHYQPKVNLTDNTIHSVEALIRWVHPERGNIRPDEFINRCEANGLIIPIGNWVINTAAQQAAIWCEQGNP-LRIAINLSVS
QLADPELICRLRTAQTQ---ASGLLDIEITESCLISNQAGMLEFINQCRELKFGIHLDDFGTGYSSLSVLASLPLTNIKLDKIFVQRIGKEGNGEPLLKS
MISMAKELGIAVVAEGVETQSQADFLKEQRVLMAQGWLYAPAMKANTLNAW---------
>tr|A3IWQ8|A3IWQ8_9CHRO Diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(S) (Fragment) OS=Cyanothece sp. CCY0110 GN=CY01
---------------------------------------------------------------------YQMEQELKEKTAFLQLVLDNIPQLIFWKDTN
SVFLGCNRLWAKAAGYEPEQVVSKT---DYDIYDPNNQH-LDPPYRKVIETGPELNFVEQKHNPEGQEVWYNTNKIPIKDNEGNIVGILGTIENITEQKL
VERSLFEEKVTLNSIGEAVITTNPQGIIEDFNPIAQQLTGFTIQEAIYQPINILKKTGKTNLINKILQNSQNQPKRHTG--ILENKNGEKCEIDIVINLI
RGQNNQILGTVLIFRDVTQASQLAHQLSWEASHDNLTGLANRRELEKQLSLAIESYKNEDVEHILCYLDLDQFKIINDTCGHVAGDELLKQVTNLLQTRV
RSSDILARLGGDEFALLLKGCSLGKAKTIANNLRQ-LVKNFRFTNEIFSVGVSIGIVSINQEIQTITSVINAADSACYTAKSRGRNCVYVYKESDDEAT-
KKIGWIIRLNQALDENLFHLYSQKIVSIQSTEKVHHEVLLRLLDDSGNLVSPLAFFPSAERYNLMEEIDQWVISNFLKKQSNLKKANFN-HVHTINLSAI
SVKNDQLCNFIEEKLSYYNVNPKHLCFEITETTAITNLSQTIKLIEGIKQLGCYFAIDDFGSGMSSLSYLKNLPVDYLKIDGNFVKHLADDSLNHCLV--
------------------------------------------------------------
>tr|B1WPM3|B1WPM3_CYAA5 Uncharacterized protein OS=Cyanothece sp. (strain ATCC 51142) GN=cce_2243 PE=4 SV=1
---------------------------------------------------------------------YQVEQELKEKKAFLQLVLDNIPQLIFWKDTN
SIFLGCNRLWAKAAGIDPEQVRGKT---DYDIYDPNNKH-LDPPYREVINTGPQLNFVEQKRNPEGQEVWYNTNKIPIKDSKGNIVGVLGTIENITERKL
VERALFEEKVTLNSIGEAVITTDSQGIIQDFNPIAQQLTGWTTKEAIYQPIKIFKNGGNSNPIYEVLRSSQNQRERRTG--ILQAKNREQYEIDMVITPI
RGQNYQILGTVLIFRDITQASQLAHQLSWEASHDPLTGLVNRRELEKQLTLALEAYKSENIEHILCYLDLDQFKVINDTCGHVAGDELLKEVTHLLQARV
RSSDILARLGGDEFGLLLKGCSLKKAEAIANNLRQ-LVKNFRFTNQVFSIGVSIGIVAINQDIKTITSFLNAADAACYAAKERGRNCVYVYQDSDYEVT-
QQIGWIVRLNNALTDNRFRLYSQKIISIQSPEKVHHEILLRLLDESGNLVSPFAFIPAAERYNLMADIDQWVISNFFKTQPDLDTTEFK-SLYTINLSAI
SLKNSQLCHFIEEQLSSYKVNPQHLCFEITETTAITNLTEAVQLIEAIKRLGCYFALDDFGSGMSSLSYLKHLPVDYLKIDGSFVKNLTKDSVNYGLI--
------------------------------------------------------------
>tr|A0A099CYH9|A0A099CYH9_9GAMM Uncharacterized protein OS=Xanthomonadaceae bacterium 3.5X GN=LF63_0104330 PE=4 SV=1
------------------------------------------------------------------------------SQALNQSMLESATVGVVL-TRN
NVVLHANRRAAEILGAADAVALEGHSASFYDSEHGRW---LAEQTRRAFDNDRRAIIEIPARRMDGERIWLRLEGAPFHH---QDYDEIWSLIDQTEQHR
AMDQQELMANALASVQEGVIITDTQQRIVYINQAFRDLTGYDFGQVRGGNYSLLQGPETDKGTIRRIHATLQDESEFVGDILNYRKDGSTFWSLLTINPL
RDSQGCLSHYVWVQRDITDLRRLTARMEYLAFHDELTGLPNRRALEHYLADALPRAMTDHHVIAVAIIDLDDFKIINDTHGHVTGDHLLNDLAQAIKPQL
TEHDFFARLGSDEFVVVFHESSPHAEHKRFASIGQCLRTPFDAGGQSIYIGLSMGVALAPRHATEGGMLLRLADEALLKAKRHKLERFSFYALVNLIEAS
QRAQLEVRLRRRLFKDGLCMLLQPIVDLHTGRLIKVEALARLTMENGALLGPDIFLPLLRNAELD-TLFQRGLDMALGDLVALERQGLH-INLTLNISPH
TLAEPECRAWVSDALERHGVPPQRLFLEILENQRVDRQAR-DDGVRRLVELGVRFAIDDLGSGYSSLRRLASLPFDAVKVDQDLLARLHIDPVQITLISA
VVQIGRDFGCEVIAEGLEDSGMIEVAQMLGAGMGQGYAIARPMKAAELPDWNRQFTL---
>tr|E6QTK2|E6QTK2_9ZZZZ Uncharacterized protein OS=mine drainage metagenome GN=CARN7_1358 PE=4 SV=1
---------------------------------------------------------------------------------VQNALLNSSVVGIIL-LRR
RVIQGCNAYYAKMLGYASAEDLRGRDTRFFTTAEFER---FGEQHDILREQGSTHVSAQKFMRQDGTVMLVDMSGTLLSGA--DDNLTVWTIEDVTARER
TRQLYQLLAQSLQSCGEADMLASTIFHAVWISQPDAQSAISVLAQAGAGASTLTDVPLVAQAKTAYHHDNLADAQGWLSSLAIPVFRGDKLWGVIDFVAD
HTQQLCQRVADFLGHGLHALSTLQTQEAYRARHDSLTGLPNRFALENYLPQALARMRRTDKLLAVGLLDLDDFKPVNDQYGHEAGDQLLREFAQRMRTDV
RESDFIARLGGDEFVVVLEDLDAQIGTVSMNRLHQSVESPFTLDGAQVMVGMTIGLALFPHDAQEADALLRQADAAMYQNKLRKVQRGRFYAELMITARA
QHLELELQLRKQLFSGGLLMLVQPIVNLHTGALVKVEALARLKLPDGEVVLPNVFLPLLSSVELN-QLFRLGLDQALSTLTALEGQGVL-VGISVNLPPS
TLLDGHCVRWVETALRHHGIAPQRLTLELLETDRIEHTTQ-DEHFMQLRQLGVGMCMDDLGSGFSSLQRLSQTRFTSIKMDQSLLAKIYLHPIQLSLLSI
IVQMGRDFDCEVVIEGLENADLIETATLMGASYGQGYGLAHPMLAQDLLAWRQNFKL---
>tr|E0URH0|E0URH0_SULAO Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Sulfurimonas autotrophica (strain ATCC BAA-671 / DSM 16294 / JC
-------------------------------------------------------------------------------KEELSELLHYLPLVAYRTRIF
KYQITVSNAIEKLTGFTRKEVESSP-SWWQEHIYEPDRE---EVLSAELFQKGYLEHQYRLECKDGSYIWIDNRAINLN-KDDMLQDILGFWNEITTLKL
HEAANK---AIAKIDRHFLIQNDEEEIFFYICK---HTVEFCEQVVLTRQSGKKYSYPESATNFK-MQKHL--EVAYADEVKIT-KH-ELFEN---IFTA
F-KNNVETGLKALLH--------ERRLNYLTYTDIICGFPNANALVEKIK----D---YKKPFALAMINIRAFSSINLLYGFEFGNEVLCRVADIIKKIL
RKEDIVYHLSGDRFCVFIN-IEADILDKIVKKIAKECAYNIMVEQRHIPISCRFGMAKYPDDSNNSSQIKDLAMTALSYASRDKKE-TVFYEDKMKEMLN
NHAETETRLIDAIAHNKFEFYYQPIVDAKTQKVVHCEALIRLKDENNKPISPEYMIHVAEELGLIKKITKIVTKNVAMQQKIWQQKGLH-VKVAINLSSY
DIEDEDFSLFFAQTIVKYGLNNKSIAVEITERTAVQNYEAAQKFLQHMKELGIPVEIDDFGVANSSLHQITEMEFDTLKIDKSFVDKILEDEKDREIVNV
ILQTAKILNVTTLAEGVETKEQYEWLKDKGCDMIQGYYFSKPLCVKDFEAYMLSYKEP--
>tr|A6Q2H2|A6Q2H2_NITSB Uncharacterized protein OS=Nitratiruptor sp. (strain SB155-2) GN=NIS_0567 PE=4 SV=1
-------------------------------------------------------------------------------QQRFEKLLEVSPLVVYEVDVD
TKENYVSQSLKKYTGFEQTD--ITS-SWWMENIHPQDKK---EVLEKELFTNGSLEHTYRFKTKDGPYIWIKDRVYVIQ-KNDENVRLLGFWIDKTKEQV
LSDLSL---RVDEILKELPRFTTKEDILRFSCQ---ELTKTFSHAWISQKCGVHQEYPDRITAYRELHNEA--MKPWRDEMALR-ID-DLYSS---MRNI
F-TKDVVQGLQSAFQ--------NIE---SNYFNHITKLPNKNSLFHDLQ----N---CHDNYLLVLVNIKDFSKFNLNFGFEFGDKLLQSIAHLLSSFL
DENRGLYHVSADHFALIVK-VSEDDAIQLLDEIQKVAKSGIIVDEVTISVILNGGA-VF-DGGEEPKRVYRKCELAMFYGKRSNS--FQIFQDWMEEHTK
EYLHYEEVLLRLLNQKDFLLYYQPIYNLKSNRFETAEVLLRVPGEK-GFYNPEKIVEVANELGYLQDLTRVILEKGIAEI---AQMQNM-LRFAFNVNVS
DLLNKDFLPFLEDLLLRHQLGTDTIALELTEKDVIANYEVLKPVITRLKERGIAMEIDDFGVGHSNFKEVVHLDFQILKIDKSLIDGMIDDSKSREIVGF
LILFSKEFHMQSLAEGVETHEQVDFLKKMGCDYAQGYYFAKPMPKERLVEFLKRNTDG--
>tr|M5AL79|M5AL79_9ACTN Uncharacterized protein OS=Ilumatobacter coccineus YM16-304 GN=YM304_17810 PE=4 SV=1
---------------------------------------------------------------------RRAESELRRSEALLRIANRAAQMSEWSIDVR
TGVVTWPDDTCALHEVPPGTSPTQE--EVLDFFVPEDRDTMRAHMRRCIDDGTPFDDELQLVSATQRRLCVRVFGLAERDRDGQIVRLECAYQDISERKA
AEMALAESHVTLMSIGDAVITADPSGDVEWMNPVAERLTGWSAEEARGKPLRVFHIEETRQPTENPMATCLQEQ-RIVGRTLLLSRTGEEYGIEDSAAPI
RDEYGQVLGVVLVFHDVTEQRLLSGEMTYRASHDELTDLINRSEFENRLRRLLQRSHDDHSQHAMMFIDLDQFKLVNDACGHSVGDQLLQQVSALLSEAV
RSHDTVARLGGDEFGVLLDHCTITQAQRIAEVICERMSERFQHEEHRFRVGASIGLVPVDEQWSTAAEVMQAADTACYAAKEAGRNRVHWYDTD--AAIR
EEMQWTTRIERALDDDRFVLYGQKIESLNE-PALHAEVLLRMCRKDGSLVQPGAFLPAAERYHLATRVDRWVLRHAT----DWLVELPDVEMLCINLSGQ
SIGDRAFHRHAVELLD--ALPPERLCLEITETAAITNLADASNFIEQIGGLGVKIALDDFGAGASSFGYLKSLDVDILKIDGQFIKDLLDDPLDDAAVRC
FVDVARLVDMKTVAEFVDRPDVLNRVRELGIDYGQGYLLHKPEPLDQLLDSL--------
>tr|C8PEZ5|C8PEZ5_9PROT Diguanylate cyclase (GGDEF) domain protein OS=Campylobacter gracilis RM3268 GN=CAMGR0001_2635 PE=4 SV=1
-------------------------------------------------------------------------RGLQEDLDFYRTVIETRNFCTCLIDLD
AQTLSFDKNYFKILKYRGKRLNSFGE--FSYEIYFADLENFNKMIRECT-AGSDFSCEFRLRNAANAYTWISMQGYVTEKHGSRSRLVKTTLEDISSRKQ
TELELNLNANVFSRSLEAILITDESGRVLRANNAFYEITGYSESQTIGKIPNFFAPTEGGADVMERIRKNLVKQTSYKDEIYGLKRGGGTFPALFTAIAI
KDDFSLTSNFILMFTEISQIKQKESELAKIAHHDALTGLPNRVYFMKAAQRFTANSGENSKLMAVLFIDFDGFKAINDTYGHEVGDMFLQAISKAMSGLL
RKGDILARLGGDEFGAIIGDLQSDAAHVLLDRLLGISKMKFNLKGNEISASISVGAAFYDGSKIDFPGLLSRADRAMYRAKTSGKNRYCIFERAEADGP-
----SEEGIAAAIEEGEFFVLYQPIISG--AQIYGYELLLRWDRGKRGILAPQDFAQILSEPRFELPISKFA----FSKMMEFNAQTG--ANCSINVSLA
VLTNDEFYDFVAHSLRDRANAKGELMFEITDFSE-QNFKEFAPARGRYADLGIKFALNS--ANKNNIPFLNAQPFDIVKIDRELCLDIGKKKNARTMVEI
TGKLKREFGFALGAQGVENALSLRLLNNLKFNYLQGNFIAKALDRKEIDAFIAR------
>tr|G2FHS0|G2FHS0_9GAMM Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=endosymbiont of Tevnia jerichonana (vent Tica) GN=TevJSym_aw006
------------------------------------------------------------------------LDVLREKEQRYRQMFETNQAIKLILDAC
GDIIEANSAASRFYGYPEETLRSLG---FHDLNQAEPLR-LGQ-LLGSIRQGQLSSFQETHRLASGREREVEIQAGPVT--TGDTELIYLIINDVTEREQ
SLKALRDNESLVEAATEGIAMLDDDGLVQLFNPAAEMMFGRLEEDLIGVGFQLFEPGEQALAWYLSNWGFSEDGG-IR-ELIGYRSNGDEFPLRLSLSPF
EL--DQRPHYLLLMQDLSESREAEQRLAYLAQHDVLTGLLNRAELERRLAVLLSTPASPRPHHVVCFMDIDQFKLVNDTGGHDAGDELLRQLAILIKSQL
KGFDLLGRVGGDEFGVILTDCSVERAESISSNLLQTIRSFFFSQERSYDVAVSIGLFGFKPGDESTSSILSSANVACQMAKEQGRNRLHTYHTGDTALVH
GDMHLVAGINQALQEGRFHLYVQPIVPVNGADGRHYEVLVRMIDEAGDTVVPDHFIPAAERYILMPAIDRWIISELFETLRQWAEVNQQEFLFAINLSGT
SLSDDGFLNYLERLFDEWRIPFRSICFEITETAAVANLEHVKVMIKRLKSFGCRFALDDFGTGLSSYSYLKELPVDYLKIDGSFVRNMATDPVDYAMVES
INQIGHILGLETIAEWAENQTILNQLRVLNVDYAQGYGVGEPMPLKEFR-----------
>tr|K0C4L6|K0C4L6_CYCSP Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor OS=Cycloclasticus sp. (strain P1) GN=Q91_1431 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------------------------------------------------------TGDGETIHTEFHGSLLNY-NGS-RHYHVSLYDQTEKIR
NQQQLQSYSAIMEASDDGMLVEDTDRKAIAINQTFFNTFDIPPSLLKEKTLEMLKAGMDKMQDAEKIAQSLSPSSEVKTSTLIYLKNGTIL--DLASFPI
H--DKTIKGRVWYFKDITENTLLTQKLGFEATHDPLTKLVNRRGFDEELSRSINDLKDSNAVHALLYLDLDQFKIINDSSGHAAGDMALIEVSQLLLKQV
RSADLLARVGGDEFCILLKDCPPDVAHALGEQIRQDIEDFIFISDKEYNLGVSIGIVTIDQSFNSYEDVLKLADTSCYLAKEAGRNQIHIHTNADQAVA-
LRLNIVSQINDALKANRFECYVQKIRTVSKNTLSNYEVLVRMLDADGSIIAPNVFLPAAERYKLMYKIDHWVIKNSIQAMATIQEQV---DWFSINLSGQ
TIAHQGSFELIKKCIDDANIPPQKICFEITETAAITNPEFGVSFLNKLQQLGCLIALDDFGSGLSSYEYLKRLPADILKIDGQFIQNMLYNPLDLAMVKS
INEISHIMGKKTVGEFVENEATLKKMKDIGIDFAQGFYLDTPKPLRTI------------
>tr|F5ZD59|F5ZD59_ALTSS Sensory box/GGDEF/EAL domain-containing protein OS=Alteromonas sp. (strain SN2) GN=ambt_11500 PE=4 SV=1
---------------------------------------------------------------------------------LLNEIGRISHVGGWELDLH
ASLVSWTRETYLLFGVTPGRDITVER--ALANFPQASREKIAKAMKASRKSMSTFALEVEYINAEGYRRWLKMTGTPQTDHQEKVYRIYGSVQDITEHKR
LSDTQHNTETILDSMADALVTIDVDGTVITANNSVEHVLGYDADELIGQDIGILVPKVESQEHLET----F-MKGDRKTHHFVSHKNGGLIPVDISLSSF
HDMQ---KRIVVVFRDMSVRKQLADQVYQAAYYDSITQLPNTKLFDKALKGVIRKAGVTYADIYCAQIAIDNISQYKQAFGQPTADYVMRILASRLTRTF
SKPFAIFRGAEDNFYLLYEDIITEDIDAVRRQFTDEVCSDITLHNSPHKIYAVVTICQLKGMKANVRHMLENTPVVFHSASSVGYDRYNFIR--------
------QSLGAAVSNHELFIQLQPQYESD-GSMVCAEALVRWQHPQLGLITPAEFIPIAEESDAIVEIGQWVMNECGKLLYECNKSGLR-TRLSINISAK
HMARADFTEKMLAVIAHWNVPKGSLTIELREAVLIGSFALVRNSMKELADKGVSFSIDHFGSGNLNLSYLRDLCIKEVKLDRHFIDEEDKIGAQSPLLNS
IFDIAKIFELRTVAEGIENTTQFNDAIKRGCHVFQGYFLDKPLNVTDWRAKL--------
>tr|A0A075NYE8|A0A075NYE8_9ALTE Uncharacterized protein OS=Alteromonas australica GN=EP13_07430 PE=4 SV=1
---------------------------------------------------------------------------------LLNEIGRISHTGGWEFDVA
QREITWTHETYCLFGMTPGRQVTLDR--ALGNFTEKSRKHIRAAILEVLRKGNAFTLEAEFINGEGHKRWLKMTGKAQCIKRPKVYRIFGSAQDITETKR
LSDTQHNTQTILNNLGHALLTLDEEGTVITANNLVRQVFGYDPDEMIGQEIFILMDKNESGSYAKG----Y-SQQSSCMALVMKRKNGGNFCADVIFSTF
FDNQ---RRTVALCRDMTEQNFQLEQLKDAAYLDRVTKLPNLHAFDTTLKRTIRECKATLGYLFCLRINIVNLDQYRQAFGGATTDYITRIIAARLERSF
SGTYTVYSESRDSYLVMYEAPLQGEINEVEWKLVNDVFGHITLHNSPHYLQANVNTCWLEGKNLCVKHMIFHERVRLYQGSTARYERYQYIK--------
------QSLLRSVENKELFIVLQPQYGDA-GNIIGAEALLRWQHPQLGLISPGEFIPIAEESDIIVEIGQWVMNETCKLLCDCQEVGIQ-TRLAINVSAK
HIARADFSESLLSIVDRWKVPPGSITLELTEGTLIHSFGLVRKRIRELALKGFVFSIDDFGRGNSNLSYLKELPIKELKVDRHFIDEVNLDGSKSLLINS
ICDMAKIFDLRAVAEGIENTHQLRYAKDCGCTGFQGYFLDKPMRVHVWREKL--------
>tr|K0CZB4|K0CZB4_ALTMS Sensory box/GGDEF/EAL domain-containing protein OS=Alteromonas macleodii (strain Black Sea 11) GN=AMBLS11_06685 PE=4 SV=1
---------------------------------------------------------------------------------LLEEVSSISKVGAWEIDRF
SGVLTLTEVMKALIGLPRVKNVSLHD--VLDLLKPSDRENLKQRVFKALRNDRQFVKHFDFHDKQGRKRSIKLTVFLQVQNGIKLTRLYGAVQDETEIQR
LSDSQHNSDSLLNNVDSVVLSIDEHGTILTANERVYPILGFEPEELIGQDIKLISTKLQNSSCFLN----L-AEG-LCSNECLRHKNGKRIACEVNLSKC
SHNQ---QLIVATVRDVTVHNHEVDHYKQLALTDLVTGLPNLNQFERYLSENPHVDRSSKPFATFLRVAICNVKEYENAFGEPTIDYILRILASRFIRIF
EVSASVFKCERGAFYIHLHQYVSEVARDCANLIHDHVLAPITLHNSLLSIETQIISCTVPTKHFSIKELLSPTGHEYFHVNASDIERYNYIK--------
------HSLSRAISNNELFVELQPQYDVN-NTVISSEVLLRWKHPHLGSVNPAEFIPIAEENDFISELGLWVCNEACKLLSECQSLKIK-TKLSVNISAK
HLARADFVSKFVATVNRWRVPHKELTLELTEGALIRGVSIIQRRVRELAEHGFSLSIDDFGIGDSNLNYLQDLPITELKVDRVFIEAIEGSQQKTLLVTS
ICNMAKALHLNTVAEGIETTGQLDQAKACGCSAFQGYFLDKPMSIEDWRLKI--------
>tr|S5AFV3|S5AFV3_ALTMA Uncharacterized protein OS=Alteromonas macleodii str. 'English Channel 615' GN=I633_07535 PE=4 SV=1
---------------------------------------------------------------------------------LLEEVSAISKVGAWELDRA
TGVFAATEVTRNLLGIRRVKSVNLNE--ILDTMVPSERAALKYKVFKAMKGERQFVRHIDIKDKQGRTKNVKLTVFLQIQGALRLTRLFGVIQDETDVQR
LSDSQHDTDSLLNSVDSIVLSIDENGTILSANECVTKVLGFEPDDLIGQDVKLIATKVQNSSYFLN----L-DAG-ICARECLRHKNGKRISCEVSFTTC
IHEQ---KLVVATIRDVTTQRYEIEHFKQLALTDAVTGLPNLNKFEHYLAEKAHEDKSAKPFSVFMRVSVRNIKEYEDAFGEPTIDYLLRILASRFVRTF
EINASVFKCDRGNFFFHLHQYFNEGAKTYAQLIQEQVLAPITLHNSLLTIETQTISCTVPIKYFSIRELLSSLTHDYFHINASDIERYNYIK--------
------NSLSRAISNNELFVQLQPQYDGQ-GSVVSSEVLLRWQHPHLGVVKPSEFIPIAEENEFIAEFGLWVCNEACRLLSDCQSQHID-TKLSVNISAK
HLARADFVSKFVGIVNRWQIPHSKLTLELTEGALIRGVSIIQYRVRELAEQGFSLSIDDFGIGDSNLNYLQDLPIKELKVDRVFIEAMEASQQKTLLVTS
ICNMAKALHLGTVAEGIETTQQLDQAKACGCSAFQGYYLDKPMNVEDWFKKV--------
>tr|K0EHD3|K0EHD3_ALTMB Sensory box/GGDEF/EAL domain-containing protein OS=Alteromonas macleodii (strain Balearic Sea AD45) GN=AMBAS45_06995 PE=4 SV=1
---------------------------------------------------------------------------------LLEEVSSISKVGAWEIDRF
TGVLSLTEVMKALLGLPRVKSVGLNE--VLDMLTSSDRRDLKQRVFKALKEDREFVKHFEFHDKQGRRKSIKLTVFLQVQSGIKLTRLYGAVQDETEIQR
LSDSQHNTDSLLNNVDSVVLSIDEHGTILTANERVYSVLGFEPEELIGQDIKLISTKVQNTSCFIN----L-PAG-WCSNECLRHKNGKRIACEVNLSKC
SHNQ---QLIIASVRDITNQNHEIEHYKQLALIDTVTGLPNLHQFERYLGDKAHDDKSSKPFATFMRVAICNIKEYENAFGEPTIDYILRILASRFIRIF
EISASIFKCERGAFYIHLHQYFSEAAHDCAILIHDHVLAPITLHNSLLNIETQTISCTVPTKHFSIKELLSKSEHEYFHVNASDIERYNYIK--------
------HSLSRAISNNELYIELQPQYDAT-KSVISSEVLLRWKHPHMGTVSPSEFIPIAEENDFIAELGLWVCNEACRLLSECQSENIN-TKLSVNISAM
HLARADFVSKFVAIVNKWRVSHKNLTLELTEGALIRGVSVIQRRVRELAEQGFSLSIDDFGLGDSNLNYLQDLPITELKVDRVFVEAMEGSQQKTLLVTS
ICNMAKALHINTVAEGIETTGQLDQAKACGCGAFQGYYLDKPMSVDDWKSKI--------
>tr|A0A0B3ZHF2|A0A0B3ZHF2_9ALTE Diguanylate cyclase OS=Alteromonas marina GN=RJ41_00635 PE=4 SV=1
---------------------------------------------------------------------------------LLEEVSAISKVGAWQIDRF
SGAFSSTEIIKSLLGLVYSKSINLQD--VLDVISNHDLDDLKLKVLRAIRGKRQFEKYFDITDKQGRRKNIKLIVFLQVESALKLTRLYGVVQDETETQR
LSDSQHSTDNLLNSIDSAVLSVDKNGTILTANENVTSLLGFEPEELIGQDIKLIATKIQNVSYLFN----L-DSG-QCISECLRHKNGKRIACDVNLKSC
SGPQ---DLVVVSIRKVSHLLTEVERFKQLAFFEPLTGLPNLHYLERYLSESSANYSAEKALSVFIKVSIVNIKEYEDAFGEPTVDYILRIMASRFVRAF
DVNVSVFKYDRKDFVLHLCTCLKDNAEKCVNFLRENVLVPITLHNSALAIETQTVSCAIPSKYFSVKEFLSEKEHLYSHFSASDIDRYNYIQ--------
------QSLGRATANNELFIELQPQYNGA-GSLVSSEVLLRWNHPHLGIVTPLEFIPIAEQNESIADIGLWVCNEACKLLSECQTKNIN-TKLSINISAK
HLARADFVSKFVAIVNRWRVEHKCLTLELTEAALIKGVSIIQRRVRDLAQQGFCLSIDDFGIGDSNLNYLQDLPINELKVDKVFIEAIEGRKEKKVMVTN
ICNMAKALELDTVAEGVETTGQLNEAKACGCSAFQGYYLDKPMSVDEWRGKI--------
>tr|A0A010QAG6|A0A010QAG6_9ALTE PAS domain S-box OS=Alteromonas sp. ALT199 GN=H978DRAFT_0855 PE=4 SV=1
---------------------------------------------------------------------------------LLEEVSSISKVGAWQIDRL
SGAFSSTEIVKNLLGLLNSRSVSLKD--VLSVISSDDLDDLKQRVFKAVKESRHFVKHFNISDKQGRTKHIKLTVFLQVEFGLKLSRLYGVVQDETEIQR
LSDSQHNTDTLLNSIDSVVLSIDTNGTILSANEYVTSVLGFEPEELIGQDIKLIATKVQNISYLLN----L-DAG-RCSSECLRHKNGKRIVCDINLRTC
SHKQ---SLIVATIRNVSNLHCEVERFKQLALHDPLTGIPNLYHFEQYSMKKAAHALSEKTLSVFMWISIINIKEYESAFGEPTVDYILRILASRFVRAF
DVNVSVFKYDRGAFILHLHRSFSDNAEECLNFLQNDVLLPITLHNSALAIETMTVSYAIPFKHFSFKELLSHKEHVYSHVSANDIERYNYIK--------
------HSLNRAIASNELFVELQPQYSGS-GSLLSSEVLLRWNHPHLGLVTPAEFIPIAEQNDLIADVGLWVCNEACKLLSECQARNIN-TKLSINISVK
HLARADFVSKFVAIVKRWRVAHKNLTLELTEGALIKGVSVIQRRVRDLAKQGFSLSIDNFGLSDSNLKYLQDLPINELKVNRVFIEAIEGSKERNLLVTN
ICNMAKALKLDTVAEGIETTGQLIEAKACGCSAFQGYYLDKPMRVDDWWHKI--------
>tr|R8AXS9|R8AXS9_9ALTE PAS sensor diguanylate cyclase and phosphodiesterase OS=Marinobacter lipolyticus SM19 GN=MARLIPOL_15162 PE=4 SV=1
-------------------------------------------------------------------QAASAYISLRDTTALVRLAESSAGFGFWELNVR
NNNLTWTDGFYTLLELRPGTDITPEQALFYCQ---SGQNRIRAFFRRCVRSGQSFSISFDLLTAKQQHRRVELTGKAIERENGRIHKIGGTLVDHTSAMH
SEQALRQSEATANATNDLVASVDRQLNLVYFNHAFSRQFGQLPR--PGGNLEMLQDFPNERRLIERLWNRALERDSFVVEMPLAQQNRDLPVYEFHYQRV
INEHGEVTGAVHVGKDISSRLNHASSREYRTLHDPITGLMNRKAFADRLRRLIKSPRRENTTDALLYLDLDDFHHVNNGAGSGTCDRYLRELASNLGVRV
RQRDALARLSGDTFALLIESCPESQARKIADSILELIGN-FEFDGHQLQTTASGGLLILTAHPDDPEQLLSQAADLCHTAKTSGRNRIHAAAPGPEEGVG
TLV---EQIRSALDNNHLILEYQAVASVTWGDH--IEILSRIPGSGQPSLQPAEFLPIAERFDLAKRLDRQVIR----QTVQWLTSQPLPKYCGFNLSLA
SVLDDTFAEFMASVLTDIPFAADCFCLEIRESHATQYPDDVAVLCDALHRVGCRVALDGAGASVESYSLAARLPVDIIKLDRRMMQHLHDDPVQQVMVEA
LHKIAEASGKTTVATFIEDDDTLRKVRTLGIHYGQGYRLYRPRPLKELKP----------
>tr|W5YNF7|W5YNF7_9ALTE Diguanylate cyclase OS=Marinobacter salarius GN=AU15_03365 PE=4 SV=1
-------------------------------------------------------------------QAASAFISQRDHSPLIRLTETSAGVGIWELDLH
SNELIWTDGMYHLLELRPGSEITPEQALFYCQ---SSQGRIRALFRRCIRTGQPFSLTLDLITARQNVRQVTLTGRALK-AGERIQRLGGTLVDHTPERN
HTLARQQAEATINATNDLVVAVDRQLNLLHFNRAFSRQFGLRPE--SGSNLAALQGFPNERRLIERLWHRAFERDSFVVEMPMAQQHRELPLYEIHYQRL
TNDQGDVIGAVHVARDISDRLQNSSSSEYRVQHDPVTGLMNRKAFLGRLQRTLEQKPRRESSDSLLYLDLDGFDHFNDIAGSGTCDRYLRELAGNLGVKI
RQRDALARLAGDTFALLIENCPEARARKIADSILELIGG-FVFHDKQLQTTASGGLLFLDDDPTDSEQLLTQAADLCHTAKTSGRNRIHAASLSLDEGTN
EVL---AQIQQALDSGHLKLEYQSVASVTWGDH--IEILTRIPGPDSPPLTPDAFLPVAERFDLAKRLDRQVIR----QTLAWLEQHRLPKYCGFNLSLA
SVLDDSFADFMEAALKGSPFAPECFCLEIREAHATQYPDDVAVLCDSLHRIGCRVALDGAGASVESYGLAAKLPVDIIKLDHKIMQHLNDDPVQQVMVEA
LHKIAEASGKVTVATFIENDDTLRKVRTLGIHYGQGFRLYRPRPLEELKP----------
>tr|G6YTQ7|G6YTQ7_9ALTE Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Marinobacter manganoxydans MnI7-9 GN=KYE_11246 PE=4 SV=1
-------------------------------------------------------------------KAASATIALCDSSSLLRAAESSAGFGIWELDTR
TNEMTWTEGMFQLLELRPGAEITPEQALFYCQ---TGQARVRAMFRRCLRTGDAFSLNLDIVTSQQNHRRVTLSCRALK-QGGRITGLGGTLVDRTADMK
LDRARQHANAVTSATSDLVVAVDLSFNLLHFNDAWARQFGGRPE--AGDNLDLLQEFPNERRLMERLWHRAFERDNFVVEMPMAQQSRQLPVHEFHYQRL
TNDQGEITGAVHVARRIEPRLNHASSEEYRIRHDPVTGLMNRKAFIARVLRTLEQKTHRESCDSLLYLDLDEFERFNDLAGSGTCDRYLRELAGNLGVRV
RQRDALARLAGDTFALLIENCPEARARKIAQETLDLIGD-FVFDGHSLQTTASGGLLILDNDPADPEQLLVQAADLCHTAKTSGRNRVHAAANQTDDSVS
KRV---EQIRDALDKQSLILEYQAVASPTWGDH--IEILCRIPTDDETTLLPDDFLPIAERFDLAKRLDRQVIR----QTLEWLGNQPLPKYCGFNLSLA
TVLDDTFADFMADALNQSPFAPDCFCLEIREAHATQYPDDVAVLCDALHRAGFRVALDGAGASVESYSLAARLPVDIIKLDRRMVQQLEEDPVQQVMLEA
LHRIAEAAGKVTVATFIESDDALRKVRTLGIHYGQGYRLCRPEPLDELTP----------
>tr|M7D8Y6|M7D8Y6_9ALTE PAS sensor diguanylate cyclase and phosphodiesterase OS=Marinobacter santoriniensis NKSG1 GN=MSNKSG1_17091 PE=4 SV=1
-------------------------------------------------------------------QAATATITPRDISGLIKSAEGLAEFGLWELDIA
SNEMFWSDGMYQQLALRTSTRITPEQALFYCQ---TGQARVRALFRRCVRTGHPFHLDLNVLTSRQTLKRMTLTGRPIK-QGGRIQRLAGTLINQTATME
QEQALERATATGEATPDLVAAVDTRLTLLHCNYPYASQFGRTPT--PGDNLELLGDFPNERRLIERLWQRAFERGGFVVEMPLAQQNRDLPVHEFHYQRI
TNSHGETLGAVQVGRNIDNQIQHAGSSEYHTRHDPVTGLMNRREFIARLLRTLEQKTHRESCDSLLYLDLDDFERFNDIAGSGTCDRYLRELAGNLGVRV
RQRDALARLSGDTFALLIENCPEAKARDIAQSILELIRN-FVFDGQKLSTTASGGLLIMEGDPRDPEELLSQAADLCHTAKTSGRNRIHAATEAMDDTVA
QRL---EQIRQALAQGELVLEYQTVASATWGDH--IEILCRIPGDNAPVLHPDEFLPVAERFDLAKKLDRQVIR----QTLHWLNGHRLPKYCGFNLSLA
SVLDDSFADFMEAELARSPFAPECFCVEIREAHATQYPDDVSVLCDALHRVGCRVALDGAGASVESYRLAARLPVDIIKLDRQMMDHLEDDPVQQVMVEA
LHRIAEAAGKDTVATFIENDDALRKARTLGIHFGQGFRLSRPQPLDALTP----------
>tr|A0A072NAZ4|A0A072NAZ4_9ALTE Uncharacterized protein OS=Marinobacter sp. AK21 GN=D777_03411 PE=4 SV=1
-------------------------------------------------------------------KAASATISYRSSANLVRSAEGSAAFGAWELNVS
QNDMAWSEGLFRILELKPGTEITPEQALYYCQ---TGQPRVRAMFRRCIRDGRPFSLSLSILTAKQHVRQVTLNGQRLS-NNTGAPKLGGILVDHTRDMI
RDNDLRKAQATTQATSDLTAAVDTNLNLLHCNHAYARQFGVVPA--VGQNLTLLEDFPNERRLAERLWKKAFERDSFVVEMPMAHLNRDLPVFEFHYQRM
TDEQGEPQGAVHVARDVSSRTNHAGSSDYRIRHDPVTGLMNRREFMNRLQRALEQKKRRQSCDSLLFLDLDDFESVNERVGNGTCDRYLRELAGNLGIRV
RQRDALARLSGDTFAILIENCPQNRARQLGDEILSLIAD-FVFEGQTVQTTASGGLLVMDTDPGEPEQLLSQAADLCHTAKTSGRNRIHTAVRQADDITG
QQV---DQIRAALDEGRLILEYQSVASATWGDH--IEILCRIPGDNQELLRPDQFLPIAERYDLAKRLDRQVIS----TTLEWLNQHELPKYCSFNLSLA
SVLDDTFADFMEQSLRHISFDPSCFCLEIREAHATQYPDDVAVLCDALHRVGCKVALDGAGASVESYSLAAKLPVDIIKLDRRMVANLEEDEVQQVMVEA
LHRIAEAAGKTTVATFIENDDTLRKVRTLGIHYGQGFRLSRPQPLAELKP----------
>tr|W5YIF8|W5YIF8_9ALTE Diguanylate cyclase OS=Marinobacter similis GN=AU14_11480 PE=4 SV=1
-------------------------------------------------------------------TAANASIHQQDSRHLLKQAECNAAFGLWQLDAR
SNEMTWTEGVFRLLELRPDSDITPEQALFYCQ---TGQSRIRALYRRCLRTGKPFTLELTLLTARQRSRRVRLYGRALK-DGQQVRRVGGSLVDLTREME
QNQARQHAEATTLATPDLVAAVDRELNLLHCNAPFQLQFGVSPS--AGDNLQLLAEHPNERRLIERLWQRAFDRDTFVVEMPLAQQNRELPVYEFHYQRL
TNNQGEVTGAVQVAKDISQRIQHSASSDYRIRHDPVTGLMNRRAFTARVLRTLEQKTHRDSCDSLLYLDLDGFDDFNDRAGSGTCDRYLRELAGTLGIRV
RQRDALARLSGDTFALLIENCPEPRARKIAEDILRLIGE-FVFEGQTLQTTASGGLLVMETDPSDPEQLLNQAANLCHTAKTSGRNRVHTASCQADDTTN
QQL---DLIRRALEDNNLTLVYQAVTSVTWGDH--IEILCRIPGEDPEPLQPEQFLPIAERFDLAKRLDRRVIS----ETLAWLSSQPLPKYCGFNLSLT
SVLDDTFPDFMETQLRQSPFPAHCFCLEIREAHATQYPEEVTVLCDALHRLGCRVALDGAGASVESYSLAANLPVDIIKLDRRIMENLDEDPVQQVMAEA
LHRIAEVAGKQTVATFIENDDTLRKVRTLGIHYGQGFRLARPQPLTELTP----------
>tr|U7NV97|U7NV97_9ALTE Diguanylate cyclase OS=Marinobacter sp. C1S70 GN=Q667_02080 PE=4 SV=1
-------------------------------------------------------------------QAATASITLRDSDAIQRLAEQNAGFGLWELDMP
SNEISWSEGMYRLLELKAGSELTPEQALFYCQ---TGQNRVRAMFRRCMRTGQPFSMDLTILTSRQRPQRVTLAGRALK-NGGRVQKLGGVMVNHSEAMV
HDLEKQQAQATTAASSDLVVAIDTEFRLLHFNTPWCQQFDLTPK--TGDNLSLLKDFPNERRLIERLWQRAFDREHFVAEMPLNRQGEGLPIYEFHFQSI
RGDRGEVTGAVHVARDISNRIQHTSNSDYRMRHDPVTGLMNRRSFIEHLERAMGHRHKRQSTDGLLFLDLDNFEQFNEDAGSGTCDRYLRELAAMLGLRV
RQRDALARLAGDTFALFIENCPEPRARKIAEEIREQIAQ-FQFEGHTLQTTTSGGLLILDSEPERADTLLTQAADLCHTAKTSGRNRIHTAPDAAGDTGD
KQL---EQLRQALDQHQLILEFQAVASVTWGDH--IEILCRIPGPDDTTLLPGQFLPLAERFDLAKRLDRQVIR----QTLDWLGQHRLPKYCGFNLSLA
SVLDDTFADFMEQLLAPSPFRAECFCLEIREAHATQYPDEVAVLCDALHRIGCRVALEGAGASVESYSLAAHLPVDIIKLDRRVMDHLEDDPVQQVMVDA
LHRIAEAAGKETVATFIESDETLRKVRTLGIHFGQGYRLSKPSPLAELKP----------
>tr|U7GR08|U7GR08_9ALTE Uncharacterized protein OS=Marinobacter sp. ES-1 GN=Q666_00185 PE=4 SV=1
-------------------------------------------------------------------QAASAEITLRDSIALLKLAEQSARFGLWELDIV
SNEIGWTEGVYRLLELQPGTGLTPEQALFYCQ---AGQNRVRALFRRSIRTGKPFRIDLSILTGKQNPQTVTLAGGTLG-DSREPQRLGGVIVNHSEAMR
HDDEKQRVRAIGNATEDLVLAVNTRLDLLHFNKPWARQFGLSPS--VGDNLKLLDDFPNERRLIERLWQRALERDSFVAEMPLNRQGEGFPVYEFHFQSL
RDPHNEVVGAAHVARDISDRLKRNLDDDRRTRFDPVTGLLNRRAFLEHLERALTHQHRRQFTDSLLLLDLDNFEQCQDSAGSGACDRYLRELAATLGLRV
RQRDALARLAGDTFALYIENCPEPRVRKLADEIREQIAS-FQFDGQQLQTTASGGLLILGGEPEHPEQLLSQAANLCHTAKISGRDRIHAAHGEQPAGSD
QQL---EQLRNALDNNHLLLEFQSVASVTWGDH--IEILCRIPGPDDTPLTPNQFLPIAERFDLVKRLDRQVIR----QTLDWLARHPLPKYCGFNLSLA
SILDDSFAEFMAQAVAPLAYKPECFCLEIRGAHATQYPDEVAVLCDALHRAGFRVALEGAGASVESYSLAADLPVDIIKLDQRVMKHLEKDPVQQIMVDA
LHRIAEAAGKETVATFIENDETLRKVRTLGIHFGQGFRLAEPQPLEQLKP----------
>tr|N6X0X1|N6X0X1_9ALTE PAS sensor diguanylate cyclase and phosphodiesterase OS=Marinobacter nanhaiticus D15-8W GN=J057_05061 PE=4 SV=1
-------------------------------------------------------------------QAATAAIQPRGRDPLLQMAETSGQFGIWQLDTY
NNQMTWSDGLYHLFDLRPGSDITPEHALFYFQ---EYQHRVRALFRRCIRSGAPFTRDLHILTAKQRLRPVRITGQALK-AGEKIIAVAGTLVDLSERLH
QRRARTEIEGIMAATDDLVLALDPNHQILAINHAMAAQFDVRPR--VGEDLRLLAEFPNERRLAQRLWDKAMRRDQFTVEMPLAQQERDLPVYEVRFQRL
KDRQGHTIGAVHIARDISHRLRTRDNLNYLSSHDPMTGLLNRRELLHRLQRAIDKTSHESPGHALLYIDLDHVTRFNETAGAGACDRYLRELATMLSSRV
RQRDALARVSADKFVLVLDTCAEPEARRVAQALTDQIGQ-FMFEGYPLQTTASGGLVPFGPAPSSAEELLTLAADLCQTAKNAGRNRIHVHGSNMLESEQ
KLL---GQLQECVREDRIVLMHQAVTSATWGEH--IEILARLEH-AEGFWLPNDFLPVAERFDLARDIDRRVIR----KTLDWLRQHPLPKLCSFNISLA
SVLDEDFANFMSRELARIAFAPDRFCFEIRESDATQYPDEVSVFCDVVHEVGCKVALDGAGASVQSYALAARLPVDVIKLDRSLMRDLHEDPVQQVMVEA
LHRIAETAGKTTVATFIESDETLRQVRRLGVHFGQGFRLSPPRPLEDLAP----------
>tr|G9PXD0|G9PXD0_9BACT Diguanylate cyclase (GGDEF) domain-containing protein OS=Synergistes sp. 3_1_syn1 GN=HMPREF1006_00519 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------HERGTSLSFEHKFMIEPGRPSWIRTNIVMVKNETGDVEGY-------TCAKN
IEAEKTTR-MLVDKFYEFAALIDVKNETFSVGAAFLPPLGLSDYDVIMNRLKCVPAGAQEQDFLERITEELEKRGAYKCYISLRAEDGHMEKRW-SY-TY
LDSSRSV--IACMRRDVTDVYASE--------TDAVTGIYNYSGFRRAVRRMIADNP--EIDFCMIRMDLDHFKVYNDLYGIRAGDELLAAIGAVGRSHS
APLRVYGHLQGDHFIACVPVLDVRSIDDVAKKL-RAIQPDFSF-----V--VRCGIYNIDDSGLDVGIMGDRALMALRSTKGRYDADFAYYDESMRAEVF
EKQELASAMKQALSGGEFRVYLQPQYDQASGKIVGAEALARWFHKG-EILSPAKFIEVFEQNGFIMQLDEYIWEQVCALMRRWLDEGRPVAPISVNISRI
DIYNPKLRKILNGLVEKYRLSTEMLRLEITETAYTQNPGQLIGVVKRLREDGFFVEMDDFGSGYSSLNMLKDVVVDMIKLDMRFLSASAGDGRSGMILNA
MVRMAHWLNVPVIAEGVETPRQADFLKTIGCSLAQGYLYAKPMPAAEFEECLSAG-----
>tr|A0A097ENW5|A0A097ENW5_9GAMM Uncharacterized protein OS=Francisella sp. FSC1006 GN=LO80_04265 PE=4 SV=1
-------------------------------------------------------------------------------------ALQALEFGMWELDLL
TNKLIWDREMLSLYETEFKEFDSSYDFWL-EKIHPEDRKAFDNEIKQSCQQKKSFGTIFRINTSDKTK-FIQLFANYLQKGNNQSKKLVGVCWDVTEKVG
LENYLRNSEKTFSNSKFGFTILDDRRKTFYLNSKDKKIQDTSIDP--STIPELLKK-----ALYEGV---IGKD-----NKAFKKSLKGLFEEDLDIVPI
FGDDKKVVGCLGIISSIGAINEQYNEIERLANKDSLTNCYSRRFFENQLDKELSNYANSQESFAVLIMDIDNFKKINDLYGHKVGDKILKEFASRVYSKT
KEKDILARLGGDEFVLLCKDTCVESIRKIAERIIETCEKPYIINNMNLNCTTCIGGAIYNTKD-SHSSLMNHADYALYEAKKEKP-SICIFDDDVRTRYI
RSNNLNVLTNKILKEESFNIVYQPIIDIKNNRCARIEALIRPQDH-LNDLRIDQVIHLIEKNGFAERLNTIVFNKVFEDMQNIKDIKEE-LVVSINISPM
VKNFPDYMLKLCDLIQQKKKDKIIIELEITESAFMKFSETDLGAIKKLHKHNIRLAVDDFGVEYSSLNRVVAYDFDTLKIDKSLTDGLEKQNNIASVFKA
LFDVAKQINLDIVVEGVETKQQLDKIHEFGGAFIQGFYFSRPQPLSEI------------
>tr|D6Z1P6|D6Z1P6_DESAT Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(S) OS=Desulfurivibrio alkaliphilus (strain DSM 19089 / UNIQEM U267 / AHT2) GN=DaAHT2_0767 PE=4 SV=1
------------------------------------------------------------------------IQELRCREGRERTVIEQAPIAICIVDQE
HRIRTVNPMLERMFGYDAEQLLQNS---LFTLL-PEVV--WHDVVPPAERRGGEFM----LQNRRGEKLTVLASAVALKEDDKPLTAL--FLTDITGRKR
TEQALAEAKVTLAAIGEGVITTNNRGVVDYLNPAAERLTGWTREDVMGMELDVFDL--RDEESRQPLSNPLDRTVNITRRALLVTNDSREFSLQITATPI
HDRQQKIIGAVMVFRDVSKIRVAERRMAREAKYDELTGLRNRREFNALLNQALAAASEEGKEHVLGYLDLDKFKIINDTCGHDAGDEVLKQVAELMQAQL
RNTDILARLGGDEFAILLSSCPMEAGHKIAEQIRRALEERFTWHGRAFELSVSIGLVQLQADSGTLDDVLKAADTACYQAKEQGRNRIQQYQPQASQGSA
AGALWQDRIRQGIAENRFTLWARRSRILSSQRLHYYELSLTLRDDQGHYLPESSFLPMAERHQLIMDVEKWKISTLMARVATTCDPNLKLATMALQVSE-
-----QLCPFILQQAERCGLNSKNIAFEINETDLTANFTRVKRLFKALKKAGFRLTIDRFGYNRGSFGHLEELAVDFLKLDAGITNSLLENHVDYILAET
VSRVGQLMRLPVIATGVDDASLLAAMEEMKIDYVLGEVIDPGRPLEEII-----------
>tr|K2JDE9|K2JDE9_9RHOB Uncharacterized protein OS=Celeribacter baekdonensis B30 GN=B30_06861 PE=4 SV=1
--------------------------------------------------------LPYAYLVQL----TDITE-MNRNSRLYKMTLEEGPALLLVQDAR
RLTLNVAPALCDSLGYDRADLIGHD---IADLTSPNTRSFVDQM--RAFGDGPPGNKVLELTTKSGKVRKMTAQRRIIDPAQGDQPKYVILLTDVTELE-
--AQRSLTETLLNRNAAIVLSQDRDWRLLSVSDAWSAHFGYTREETLGRDLDFMPVEDQSKSFRRHLLANTRNKETISNTLTLLTKSGEPRIVELRSVIE
EN-EDRWLNII-MVIDITDISVARQKLEHLVDHDELTGLYSRRGFNSRFAD-----RKRRQDVDVFLIDVDHFKSVNDAYGHETGDELLRKVAGVLKDKT
RAHGCASRIGGEEFAIIRTATQGCPNRKFAEDLARAISETAVTASGPVTRTVSIGVARLTQDM-RLEDGMNWADWALREAKEGGRNRIVIADEGFSQKLR
DKLTTHRDIISALEAGEINKYVQPIWDVTRAEIVGFEALMRWQRASGEVVLPRQFLPLAEEYAHIPSIRRSLLNTAC-----------PGTYICFNTR--
-LESLGFQGAAQAILREFEPLSHSIVLEIGEQAITDRIDQVMVEIAILRARGIRVALDDFGKEGSNLNRLTHLPIDIVKIDKSLIDRIVIDRRSREALRS
IARLAEALEFEVIAEGVETEAQRDMLLDLGLHLHQGFLYARPMSAEAANALY--------
>tr|A0A011WRL3|A0A011WRL3_RUMAL Diguanylate cyclase OS=Ruminococcus albus SY3 GN=RASY3_07305 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------DDDFFRYTGYSHDYVLENE-LTFFSLFDENVREDIEEYVSNAANDNRAFCVRQPITARDGHSIFIHCCGII-ND----RSRVQVVFSDCRCHDR
LMRKVQEQRMIAENTDDVYYDYEVKRDIMHLTVSITRLDYDSLENFLGTRAEFLH--PEDRDAYFDAWEEALQKP-MKGEFRTKAYDDDYCWYSDAYISF
ADESGKVTEVFGRLSNIQKLKSDTEYIKFLLQSDQLTGLYNRKGFTQQAMDIL--AKREKMVYALVYSDINEFSYVNENFGYETGNAMLRDYT----NCL
RGGASFCRIYSDFFICLCKAKTRPALIRSVEQFTTMQKKKF--PSGD--IRIACGMYILPDGEIELNTAIDNANLARRSVKHSSSILCGIYSQRMRMQKL
YEQSICNELHAAIRNRQIEMFLQPKFHLEKRVIIGAEALARWRNPNGTYKMPFEFIPVLEKVGYIDELDFFIYGEVLRTLEKWKHDGRKVLPISVNFSQH
HITQPKFVENIIRTADCYDVDRGDIEIEITESCFSGDTQSLFSVMDKLRNEGFKVSIDDFGIGYSTLSVLMNAPVDIVKIDKSFIDNIEQNKTDRDFVAN
MCSLIDTAKKDIIFEGVETDAQAAILCQSGYTKAQGWLFDRAMPLSDFEKK---------
>tr|E6UE30|E6UE30_RUMA7 Diguanylate cyclase/phosphodiesterase OS=Ruminococcus albus (strain ATCC 27210 / DSM 20455 / JCM 14654 / NCDO 2250 / 7) GN=Ruma
----------------------------------------------------------------------------------------------------
------DDDFFRSTGYSLDYVLEKE-VSFYSLFEDKAREDIEAQINSAAEVGGVFCVRHNIITRDGSSMFVHCCGIV-KN----LKCVDIIVSDCNCHDR
LIRKVEEQRMVAENTDDVYYDYDVKRDIMHLTVSITRLDYDCLENFLGSRAEFLH--PDDCEAYFDGWKSALERP-MKGEFRTKAYDDDYCWYSDAFISF
ADESGKVTEVFGRLSNIQKLKKDSEYIRFLLQTDQLTGLYNRKGFTQNAANAL--SERQEMVYAIVYSDINDFSYVNENFGYETGNTMLRDYT----ACL
RGGASYCRIYSDYFICLCRSKNRAALIRSVEQFTTMQKKKF--PSGD--IRIACGMYILPDGDIELNTAIDNANLARRSVKHSSSILCGIYSQRMRMQKI
YEQSICNELHSAIKNRQIEMFLQPKFHLEKRVIIGAEALARWRNPNGTYKMPFEFIPVLEKVGYIDELDFFIYGEVLRTLEKWKHDGRSIIPVSVNFSQH
HITQPKFVENIIKTADKYDVDKGDVEIEITESCFSGDTQALFSVMDKLRSVGFKVSIDDFGIGYSTLSVLMNAPVDIVKIDKSFIDNIEQNKNDRDFVAN
MCSLIDTAKKDIIFEGVETDAQAAILCQSGYTKAQGWLFDKAMPLDDFEQK---------
>tr|E9SAX5|E9SAX5_RUMAL Diguanylate cyclase (GGDEF) domain protein OS=Ruminococcus albus 8 GN=CUS_8088 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------DDDLFGFTGYSQDYVRENE-LTVFSLFDRAYREDTETILNDAAKEGRVFCIRQPMNCRDGSSLFVHCCGYV-RD----CSRVEMVISDCRCHDS
LMRQITEQQMIAENTDDVYYQYDVKHDLMHLTVSITRLDYDCLENFLGRRAEFMH--PDDVKAYFDEWEKALKKP-TKGEFRTKAYDDDYCWYSDAYISF
ADENGEVMEVFGRLANIQKLKSDSEYIKYLLQSDQLTGLYNRKGFTQQAGNLL--SRREEYIYALVYSDINDFSYVNENFGYETGNTMLRDFA----ECL
KAGSTYCRIYSDFFITLCRAKSRAELIKSVEVFTALQKLKF--PSGD--IRISCGMYILPDGEVELNTAIDNANLARRSVKHSSSILCGIYSQRMRMQKL
YEQSICNELHAALENRQIEMFLQPKFHLEKRVIIGAEALARWRNPNGTYKMPFEFIPVLEKVGYIDELDFFIYEEVLRTLEKWKRDDRVLLPISVNFSQH
HITQPKFVENLIDTANRFDVDKSFVEIEITESCFSGDTQALFSVMERLRNEGFKVSIDDFGIGYSTLSVLMNAPVDIVKIDKSFIDNIERNKNDRDFVAN
MCSLIDTANKDIIFEGVETDAQAAILCQSGYTKAQGWLFDKAMPLSDFEGK---------
>tr|R7MTE9|R7MTE9_9FIRM Diguanylate cyclase/phosphodiesterase OS=Ruminococcus sp. CAG:624 GN=BN739_00336 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------TKKFYDIIGYSPEEYLANG-GYIDQLFSDEERERVLKIIYASIKDKIEFSVRTEMFKSDKSEIFVQINGAV-YV----TPKLQLAYTDITEN--
-ENIIRLQNILEETTEEFFFDYNVADDIFTLPVKCIDIFGRVFHGYLKNDLNFIQ--KSDYWKYITVLRSASISP-QKNDIRINAFTGDMQWYRIHYVSL
PNISGKISHIYGRIKNIENEKESEEAIKRLSSTDYVTGLLNRHSFNEKANKII--SKYNGDSLAIVYSDINNFSYINENFGYDAGDNMLFDFS----SSL
NKLDNMSRINSDFFAYIINNPDRETVISSVDRFINLQKQKY--PECE--IGVSTGIYFITDNTIDATVAMDNANLARRHIKRDNNSSICIYDEQLRMARK
QEQKIISQLRTAIDEGFIEMFLQPKFSITTRQVIGAEALSRWRNVDGSYKFPTEFIGILEKTGYIGELDFYIYELALRLIRKWLDEGYEPIPISVNFSRI
NNSDTCFTEKIISLAEKYNVDRKYIELEITESAFTENSKSLLLNMKHLRERGFKVDIDDFGIGYSSLSLLLDAPIDVVKVDKYFVDSIDNSSLHKEYLRQ
MCLLINTTKKEIIFEGVETEDQAEFLNACGFDSAQGWLFDKAICVNEFENK---------
>tr|A3JQI1|A3JQI1_9RHOB Sensory box/GGDEF domain/EAL domain protein OS=Rhodobacteraceae bacterium HTCC2150 GN=RB2150_05958 PE=4 SV=1
----------------------------------------------------------------------------------------------------
--------------GFSRDETIGKD---FVSFLVEEERDRREARQVAETQTGDEAVNTWTLRTKSGAKLQVTIMGAGVTVPTAQETMSVSSVSDVTDLAK
Q---KTLAETLLNRNAAMIISQSDDWKIQTCSDAWVTQLGYTREETVGHDLTFM--EPEDAIISKEFRETLKSENVVHNTLRFRSKVGELRQIKLQ-SVV
AALEGNFVNIVTL-VDVTDIMHTQNQLQMLVNQDELTGLYSRRGFKDRYSDGMRK-----KTAGVYIFDLDHFKSVNDSYGHEAGDALLSAMGQTMKRLT
ETNGCAARLGGEEFAIIRPW-QGEEAKEFGDALRLALEQTVVVRARPISRTASIGIAMLPVSE-ALSDAMRLADDFAREAKKRGRNMVCASEEEELRALG
LRFITLKDLQSALEGGEMQYYVQPIWNVKKKRIEGFEALIRWIQPEGIIVMPGLFIGLLHEV--IRKPKYLSFK---TQLRKDLLSAFPSQYVSFNFNLE
QLSYAGAAQDVHKTLSGIDHPGREIIIEISEKAMNSRTNLVKAEIVALQDYGYKIALDDFGVEASNLNRMQQFPISILKIDQALIKDINTSEVQRATLRG
LELITQSLGIKVIVEGIESIDQAHYLYQIGFYSHQGYLHAHPMPPEDVVANLSAIGF---
>sp|P38097|YEGE_ECOLI Probable diguanylate cyclase YegE OS=Escherichia coli (strain K12) GN=yegE PE=2 SV=2
---------------------------------------------------------------------------------RITLANEAGGIGIWEWELK
PNIFSWDKRMFELYEIPPH--IKPNWVWY-ECVLPEDRQHAEKVIRDSLQSRSPFKLEFRITVKDGIR-HIRALANRVLNKEGEVERLLGINMDMTEVKQ
LNEALFQEKITLDSIGEAVVCIDMAMKITFMNPVAEKMSGWTQEEALGVPLTVLHIGDNGP-LMENIYSATSRSAIEQ-DVVLHCRSGGSYDVHYSITPL
STLDGSNIGSVLVIQDVTESRKMLRQLSYSASHDALTHLANRASFEKQLRILLQTVNSTHQRHALVFIDLDRFKAVNDSAGHAAGDALLRELASLMLSML
RSSDVLARLGGDEFGLLLPDCNVESARFIATRIISAVNDYFIWEGRVHRVGASAGITLIDDNNHQAAEVMSQADIACYASKNGGRGRVTVYEPQQAAAHS
ERAAMDEQWR-MIKENQLMMLASPRIPEARN--LWLISLKLWSC-EGEIIDEQTFRRSFSDPALSHALDRRVFHEFFQQAAKAVAKG---ISISLPLSVA
GLSSATLVNDLLEQLENSPLPPRLLHLIIPAEAILDHAES----VQKLRLAGCRIVLSQVGRDLQIFNSLKANMADYLLLDGELCANVQGNLMDEMLITI
IQGHAQRLGMKTIAGPVVLPLVMDTLSGIGVDLIYGEVIADAQPLD--------------
>tr|D6CMS0|D6CMS0_THIA3 Thiomonas sp. str. 3As chromosome, complete genome OS=Thiomonas arsenitoxydans (strain DSM 22701 / CIP 110005 / 3As) GN=THI_3252 PE=4 SV=1
------------------------------------------------------------------------------------DFIGSLRDVVFRTRGK
TFWSYLSPAWTTLTGFTVEESLGRN---ILDFVYPDDRP-ANSLRKQQLESGSASRHTKRLLRRDGSFVWIEVDLRVLYDGDGAFLGSVGTIRNISDRIA
LENAIRHERVTLMALSDGVLTLDPQRRIEFLNHAAADLLGLKLIDYALHRPTALESGDIRARAQQQM-HT------LDGRCRLHATEADWSDVDLTVIPL
SEAD---EGCIIVLRDVREQRALQARLHHQARHDALTQALNRVGMLDELGRTHAGFLRTGATFSNILLDLDHFKRVNDQHGHAAGDEALRLVARAIQGAL
RADDHLARWGGEEFLCLLPHTSLEQAIAIAERIRAEVQA-LELKRQPIPLTISAGVSASPDRGDTLEQMLQRADFSLYEAKQAGRNC--VWHERMTGEG-
-VLDLASQAQEALRAGRLDLMYQPIISLTTGAQVGQEGFARMRLPDGTPLKAARFMPALQQMH----RAHWVDEEDCLQGRL---QG----DCFINLSAD
LLRRPTLMHALDDFLQRTAHSRGRIVLELDFRAQQLDLGAACTALQPWMAAGARLALKQSGPDLPTLAHWTELPIRFLKIHAAHLKRAATAPKAHLILSS
IVRLAKQLGCLTVADQVDQIDQPDLLRELGLDWLQGDHADQPPP----------------
>tr|D0I8U2|D0I8U2_GRIHO Uncharacterized protein OS=Grimontia hollisae CIP 101886 GN=VHA_002279 PE=4 SV=1
----------------------------------------------------------------------------------------VGELGIWEYEPH
TATLYWNREMYALYGISEEEEITLE-TWRERLL-DADRHPFDTLFNLGRIHNEHLTLNIQVKHTSDLIVNHSISARII--HAESGTRLAGFCQETTRLQK
ENVVLTRESAAIESVNDGIIVLDSLLRITFINQHAAELTGYPASDLIGSTIDVF--DHHSQYAFAHLLSDYHQDFCLSGTFTLQTEQFQETLVYLEATPV
APHNNATNGWVLTFRIQDALPSRAANSEGRYSVDPITKFPGKRAFEQILQNHTDNLHYETVSHVLVMIELKGLETLADAFGDPVKDQLIKSAAILIKSYA
--TKSVARLSESRFGLLLDNQGLGSMSSLSEKICALKYQ---PGETAYHLECVMGMTLIEGNQKTPFQIIYQAQVAMESVSDDCHPAISVFDPSSLTDSF
RRDFLLQRIDIAITNRSFSLLCMPIMSNRNGLQNWHEVLVRLITEEGQLLLPAEFLPAAEPTGRLISIERWVFNEVLEQAQTLAAAGL---NIAINISAS
AFYNESFIDYCLALIKKSNLPSRRLCIEIKESTLLIDTLRAKDVVSSLRKLGCEVAVDNFGTELTSFSYLRKFNVSIIKIDGSLIAMMKASLVDRRIVES
IKQICDSLRIKTAAQKVNSDEDLRLVQAAGLDYIQGYVFGDPLPLARVI-----------
>tr|R1ITW6|R1ITW6_9GAMM Uncharacterized protein OS=Grimontia indica GN=D515_04881 PE=4 SV=1
----------------------------------------------------------------------------------------VCDFGLWEYTPE
TEQLYWNEEMYALFELHNGEHMTTS-LWRERVL-PSDRHQLDSMFNITRMNNDQLSFNIQVQNAHGHVVYHHILARVI--HSESGSRLVGLCQETTLIQR
ENVQLEREATAAESVTDGIVALDSLLRITFINRHASVFTGFSPEELVGTNIDIF--DRQNQYTFAHLLSAYHQDFRLRGTFTLQTEHNQEKLVYLEATPV
ILDGAAPSGWVLTFHYQTATAERIAGLEEKSAIDTLTKLPNQRAFEHRLQSHIDSLKG-TEPHALVVIEISGLDILTDAFGEQIRDQLIKSVALLIKALG
--KQCVARISDTQFSMLLEHESVEHLVTLAEKIGALKYQ---QGDFSYPLGCSMGLTAADDTNNTPFQLIYQAQVALESISEGSQHAISIFDASLLKDSF
RRDFLLQRIDTAISANSFSLLSMPIVPTNQEDQTWHELLVRLITEDGDLLLPAEFLAAAEPTGRLISIERWVFNEVLTQASALAQTGM---SVAVNISSG
AFYNDSFMSYCLGLIKKSALPAQQVCIEVKESTLLIDTVRSQQIVSSLRKLGCEVAVDSFGAELTSFGYLRKFNISLLKIDGSIISMMKSSKVDRRIVES
IKQVSDSLKVKTAAQKVNSDEDLRQVMEVGLDYTQGYIYGEPVPLARII-----------
>tr|A0A0D8HJU8|A0A0D8HJU8_9ACTN Cyclic di-GMP phosphodiesterase Gmr OS=Acidithrix ferrooxidans GN=gmr3 PE=4 SV=1
----------------------------------------------------------------------------------------------------
------------------------------------------------------------YRTITGEKVFLDMSGRLLNFGD-GITRIVWTQIDVTDRVE
ADRQRNEIGVLLNNTVAGIDLVEPTRRIIEANLAFAEMLGYGDTELIGMNTSTLYTLDSENARMAALSRSVLSSG--QGDLQVLKKDGSTIYVDIHGRYL
DGGDSESQVVVWTSVDVTGRHQLNDELRRFANFDSLTNLPNRRALHQYLEEAIARARSDERHLAVGVIDLDDFKPVNDVYGHLSGDELLKEFARRLKSVL
RSGDFASRLGGDEFVVILEGLSKSQLETVLLRLYETVESPFEIDGHLVNVGMSMGISFSNPTIDEPDILVRMADSAMFAIKKLKGNRKRFYDDEMNIRSI
DRLRLEARLRKLLYSGALTMYAQPIVDIASGDTIKVEMLARLTSFDGSVITPGQFLPSFSDGDLD-TLFLQGLDQSLRQLQAWDRQGLK-IDLSMNIAPS
TVLNPQSNLWLKQHLDTYSIDPQRITLELVENQEIAG-DRHSDAVRTLSKIGIRLAIDDLGSGYSSLKRLASLPFDVIKVDQSIVRALKYDPIALSLIRT
IIQIGDDFDRYVIVEGLESRAEIEAIHLLGATIAQGFEIAKPMPAGMIYKW---------
>tr|A0A069I3E4|A0A069I3E4_9BURK Uncharacterized protein OS=Cupriavidus sp. SK-3 GN=CF70_021460 PE=4 SV=1
------------------------------------------------------------------------------PHHDYRALVDGIEDIVFETDAD
ATFHFLNHAWKSVTMLDVHLCLHTP---VFRYVHPDEQALREQFLTILSQNSDACRYETRLICHDGRPRWMEVRLRPRFDGHGRVTGTTGMMTDIQSRKR
AEDVLRARDTLLDHLPGMAFRNDRRWTMEFVSDGCFELTGMEAVDLLNHPSELIHP--DDRAY---VWDYLAQHRAFHLRYRIRTHAGQEKWVSERSRGI
FAGNGTLLAIEGFISDISSQKRDEERAEREPLHDRLTGLKSRALLLDRIDLALR----YGAPFMLLCLDVDNLKRINERHGRAFGDQLLARLGERLATCC
GPGISAGRSGGDEFAILVLQAPAEGALTLVDTIAAMLETPFEIDGISASINARLGIAIRIANQPDARSLLRDALRAVYSAQWQSANRYAFAGEAARRTAQ
AWRRSLGEFARAFSSQGLQVSVAQVIPLGDGP-RWAEGSACWHSTRSGTIPAAHLFLYAAQAGTLDQLAERYLLAIFDQAYPLLEPQQ---RLCLCLDAV
PL-DAMVLRGLQGALRAIGDKATLARIDVLLPQFADRGLALDVTLAGLRRDGVRLGVDLTP-----AAAHDGPPLPTLLADFWRIR-MDAGAADTSRLAR
LLRIAARHGIPVAAAGEPDA----------------------------------------
>tr|I9W7F3|I9W7F3_9RALS Uncharacterized protein OS=Ralstonia sp. PBA GN=MW7_0909 PE=4 SV=1
------------------------------------------------------------------------------RERDYRALVNRVDDVIFETDTD
ATLTFLSDAWKNVTLLDVQACLHTP---LFRYLHPDDHALREQFLTLLSNRGGPGRYETRLINRDGQQCWVELRIRPLTDRRGTVTGITGVMSDIQSRKR
AEDILRARDTLLDHLPGMAFRNDRSWTMEFVSDGCFDLTGYEAVDLLNQPSKLIHA--EDRRY---VWDYLAQGKAYHLRYRLRTREGQEKWVDERGRGV
FAGDGALLAIEGFVSDISSQKREEERVEREPLRDTLTGLKSRALLTDRITSAME----QQRPFLVLCIDIDNLKRINERHGRAAGDALLRGVGERLAALC
ASGLAAARHGGDEFAILAPLDHPPEGLALADRIARLLERPFVIADRTLSLTARIGIALSTDKHADAGAVLQSALHAAYSAQWSDTGRYAFAGDDVRQAAL
AWRHSAAEFAREFNMTDLSVTLARVIALATLP-DWREARLQWHSPRIGIVPTAHLFTHAAANGTLGTLAEAATRLLCARALPQLQAGE---RLCLSFEDA
LP-DNALLLGVQHGLPATDAG-TSATCDILVPALPEPLTALDAAFTTLREAGVRIGIDITI-----LGHANEIPAPLGRADYWRIR-FDATRPLPARLAR
MIETAAAHGIPVVAAGATTH----------------------------------------