>seq_1
MTADKEKKRSSSERRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIA
VVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVK
VYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHLMAMNSIFDSSGKGAVSEKSNFLFTKLKEEPEEL
AQLAPTPGDAIISLDFGNQNFEESSAYGKAILPPSQPWATELRSHSTQSEAGSLPAFTVPQAAAPGSTTPSATSSSSSCSTPNSPEDYYTSLDNDLKIEV
IEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVAPHSPFLLDKFQQQLESKKTEPE
HRPMSSIFFDAGSKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLHFGPTKWAVGDQRTEFLGAAPLGPPVSPPHVSTFKTRSAKGFGARGPDVLSPAMV
ALSNKLKLKRQLEYEEQAFQDLSGGDPPGGSTSHLMWKRMKNLRGGSCPLMPDKPLSANVPNDKFTQNPMRGLGHPLRHLPLPQPPSAISPGENSKSRFP
PQCYATQYQDYSLSSAHKVSGMASRLLGPSFESYLLPELTRYDCEVNVPVLGSSTLLQGGDLLRALDQAT
>sp|Q16665|HIF1A_HUMAN Hypoxia-inducible factor 1-alpha OS=Homo sapiens GN=HIF1A PE=1 SV=1
AGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGD--LDIEDDMKAQMNCFYLKALDGFVM
VLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGL--VKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIH
VYDTNS-NQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKG
QVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVDMKMTQLFT---KVES-EDTSSLFDKLKKEPDAL
TLLAPAAGDTIISLDFGSNDTEEVPLYNDVMLPSPNEKLQNIRSSADPNPESLELSFTMPQIQDQT-PSPSDGSTRQSSPEPNSPSEYCFYVVNEFKLEL
VEKLFAEDTEAKNPFSTQ-D-TDLDLEMLAPYIPMDD-DFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQTANAT----TTTATT-DELKTVTK
DREDIKILIASPSPTHI-HKETTS-ATSSPYRDQSRTASPNRA----GKG---VIEQT-------EKSHPRSPNVLSV---A-LSQRTTVPEEELNPKIL
ALQN-AQRKRKMEHDGSLFQAVGIGTDDHAATTSLSWKRVKGCKSSEQNGMEQKT---------------------------------------------
--------------IILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
>sp|Q9YIB9|HIF1A_CHICK Hypoxia-inducible factor 1-alpha OS=Gallus gallus GN=HIF1A PE=2 SV=2
PGGVTDKKRISSERRKEKSRDAARCRRSKESEVFYELAHQLPLPHTVSAHLDKASIMRLTISYLRMRKLLDAGE--LETEANMEKELNCFYLKALDGFVM
VLSEDGDMIYMSENVNKCMGLTQFDLTGHSVFDFTHPCDHEELREMLTHRNGP--VKKGKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIR
VYDTCN-NQTHCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKG
QVTTGQYRMLAKQGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVQKDLIFSLGQTECMLKPVEMKMTKIFS---KDDW-DDTNSLFEKLKQEPDAL
TVLAPAAGDTIISLDFSSNE-DEVPLYNDVMLPSSSEKLQNIRSNADPNTETLELSFTMPQVQEQP-TSPSDASTSQSSPEPSSPNDYCFDVANEFKLEL
VEKLFAIDTEAKNPFSTQ-E-TDLDLEMLAPYIPMDD-DFQLRSFDQLSPLESSSSGSQNAATI---TILQQTQ-----T------PSTAA-DEIKPV-A
ERDDVKALIVPSSPVHV-IND-TSSAPASPYSGRSRTASPIRA----GKG---TLEQT-------EKSCPGAPSLITV---T-LNKRSTAMDEELNPKML
ALHN-AQRKRKMEHDGSLFQAVGIGSGDRGGNASLAWKRVKACKTNGHNGVEQKT---------------------------------------------
--------------IILLSTDIASKLLGQSMDESGLPQLTSYDCEVNAPIQGNRNLLQGEELLRALDQVN
>sp|Q9I8A9|HIF1A_XENLA Hypoxia-inducible factor 1-alpha OS=Xenopus laevis GN=hif1a PE=2 SV=1
SVVVSEKKRISSERRKEKSRDAARCRRSNESEVFYELSHELPLPHNVSSHLDKASIMRLDHQLPAVEKVADAGD--LDGETELDKQLNCFYLKALEGFVL
VLTEEGDMIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTFRNGP--AKKRKRTNHREKFLPSYEMYINQS-----WKNREYKVSHMRTHAC
IYDNAN-NQNHCGYKKPPMTCMVVICEPIPHPSNIEFPLDSKTFLSRHSLDMKFSYCDERVTELVGYEPDELLGRSVYEYYHALDSDHLTKPNYNMFTKG
QVTTGQYRMLAKKGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSEVVEKDLILSLGQTASVLIPVEIKMPEIFT---ELNEENNSECLFDKLKQEPESL
TVLAPDAGDEIIPLDFSSGDSEDVPLYNDVMLHSTSNKLESTRSNVDPNPRTTCASIHHSTAIQA------------RQPFEPNTPEYCFDVASEFKLDL
VEKLFAIDTEAKAPFYYP-G-NDLDLEMLAPYIPMDD-DFQLRTFDQLSSLECDSSIPQTLGSMTT--LFHQSL-------------SPST-SDFK--PE
DASDLKTIIQS--PVHM-MKE-STSAPVSPYNGRSRTSSPVRP----AKA---VVDKT-------EKSRPGTPN-LPV---P-LNKRCTILDEELNPKMI
CFTQCTAEKRKMESDGPLFQAIGIGTVDPGPNSSLQWKRVKGSDSERLSSAEQRT---------------------------------------------
--------------ILLLSTDMASQLLGQSFDGTVLPQLTGYDCEVNAPVHGTRNLLQGEELLRALDQAN
>sp|Q98SW2|HIF1A_ONCMY Hypoxia-inducible factor 1-alpha OS=Oncorhynchus mykiss GN=hif1a PE=2 SV=1
GVVPEKKSRVSSDRRKEKSRDAARCRRGKESEVFYELAQELPLPHSVTSNLDKASIMRLAISYLHMRNLLSTDNEEEQEEREMDSQLNGSYLKAIEGFLM
VLSEDGDMIYLSENVNKCLGLAQIDLTGLSVFEYTHPCDHEELREMLVHRTGT--SKKSKEPNTERSFFLRMKCTLTNRGRTVNVKSATWKVLHCSDHVR
VHESPA-EQIPGGHKEPSVPYLVLVCDPIPHPSNIEAPLDTKTFLSRHTLDMKFTYCDERITELMGYDPEDLLNRSVYEYYHALDSDHLMKTHHNLFAKG
QVSTGQYRMLAKRGGFVWVETQATVIYNNKNSQPQCVVCVNYVLSGIEEEKMMLSLEQTEDMLKEEELDVIKLFT---RAVETQPLSSLYDRLKEEPEAL
TLLAPAAGDTIISLDFSSPDSKEVPLYKDVMLPSTSDKLAL-NTSVD-----------TTEVS----TGPDSS----S---PDSPLDFCFPMNAEFKLDM
VETLFAINPEPKTPFTLQ-AMEDLDLEMLAPYIPMDD-DFQLRTLSPEEPLSCGPAQPLECSSLCSSVRLTQE---------------------------
----------------------VHSYPGSPFNAGSLTASPALA----ASP---ALAAPEP----ADSPCPASL----------LTKTVPQMDREISLRSL
ASQN-AQRKRKM----SLSQAVGIGGPGPGKKL-------KVSELSHADAPFNRT---------------------------------------------
--------------ILLLPTDLASRLLGISSEGSGLPQLTRYDCEVNAPVGGRQLLLQGEELLSALDQVN
>sp|Q9JHS1|EPAS1_RAT Endothelial PAS domain-containing protein 1 OS=Rattus norvegicus GN=Epas1 PE=2 SV=1
MTADKEKKRSSSELRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIA
VVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLKTGSGFGKKNKDRSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVR
VYNNCPPHSSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVVYNPRNLQPQCIMCVNYVLSEIEKNDVVVSMDQTESCSSHTLMAMNSIFDTSDDVALSEKSNYLFTNLKEEPEDL
AQLAPTPGDAIISLDFGSQNFDESSTYGKAILPPGQPWATELRSHSAQSESRSLPAFTVPQAGSPGNATPSA---------PSSPEDYYSSLENHLKIEV
IEKLFAMDTEAKDQCSTQTDFNELDLETLAPYIPMDGEDFQLSPICPEEPLVPESPQPNPQHCFSTMSSIFQPLTPGASQGTFFLDKYPQQLESRKTESE
HWPMSTIFFDAGSKGSLPPCCGQASTPLSSMGGRSNTPWPPDPPLHLGPTKWSVGNQSAEPLLPLGLEPPSTPPHVSMFKMRSAKDFGARGPYMMSPAMI
ALSNKLKLKRQLDYEEPAFQDTSGGDPPGTSSSHLMWKRMKSLMGGTCPLMPDKTVSASMAPDEFTQKSMRGLGQPLRHLPPSQPPSTRSPGENAKSGFP
PQCYASPFQDYSPPGAQKGSGVASRLLGPSFE---LPELTRYDCEVNVPEPGSSTLLQGRDLLRALDQAT
>tr|F7G7B7|F7G7B7_ORNAN Uncharacterized protein OS=Ornithorhynchus anatinus GN=HIF1A PE=4 SV=2
--------------------------------------------------------MRLTISYLRMRKLLD-TGDL-EAEAEMEAQLNCFYLKALDGFVM
VLTEDGDMIFMSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTHRN--GSVKKGREQNTERSFFLRMKCTLTSRGRTVNIKSAAWKVLHCTGHIR
VYDACS-NQAQCGYKKPPMTCLVLICEPILHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKG
QVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVQKDLIFSLGQTECVLKPVEMKMTQIFSKAD---P-EDTSSLFDKLKKEPDAL
TLLAPAAGDTIIYLDFGNQLLDEVPLYNDVMLPSSSEKLQNLRSSADPNSEPLELTFTVPQLQERP-ASPSDASTDQSSPEPSSPSEYCFNVASEFKLEL
VEKLFAEDTEAKNPFSAQ-DT-DLDLEMLAPYIPMDD-DFQLRSFDQLSPIETGSAGPP----NGNPIAIFLP-----P-----------TTDKLKAGTP
EGDDMKTQIVSPGHA-TETT-GAPASPYGGARSRTASPARAG------KG---VIEQT-------EMSHPRSPNLLSVT----LSKRTTALDEELNPKML
AL-QNAQRKRKMEQDSS-LQVVGI-SLDNETNTSLSWKRVKGCKSSEQSGEEQKT---------------------------------------------
--------------VVLLSSDLASRLLGQSMDESGLPQLTSYDCEVNAPIQGNRNLLQGEELLRALDQVN
>tr|G3SJ03|G3SJ03_GORGO Uncharacterized protein (Fragment) OS=Gorilla gorilla gorilla GN=HIF1A PE=4 SV=1
--------------------------------------------------------MRLTISYLRVRKLLD-AGDL-DIEDEMKAQMNCFYLKALDGFVM
VLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRN--GLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIH
VYDTNS-NQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKG
QVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVEMKMTQLFTKVE---S-EDTSSLFDKLKKEPDAL
TLLAPAAGDTIISLDFGSQQLEEVPLYNDVMLPSPNEKLQNIRSSADPNPESLELSFTMPQIQDQT-PSPSDGSTRQSSPE------YKFDS--NHKLHL
CVCL---------NFSTL-K----LLQELLPNLDLST-CFRLKNWSRLFPIAHSKLSLP---SSAFNIDIYRPLFWTDR------------MNTVIKMTI
---TYKLQFYRGIQFSEQLFSCTCQSQSVTTHQVTLKPKKTA------KL---LILDT-------HSSCLITRSILSAC----IS---------IVP-TI
SL-HCYIFSVKLSFDGHMFWGKSV-TLDHAATTSLSWKRVKGCKSSEQNGMEQKT---------------------------------------------
--------------IILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
>tr|H3BFY0|H3BFY0_LATCH Uncharacterized protein (Fragment) OS=Latimeria chalumnae GN=HIF1A PE=4 SV=1
--------------------------------------------------------MRLTISYLRMRKLLG-AGEF-EAEADLDKQLNSCYLKALDGFVM
VLTEDGDIIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTHRN--SPVKKSKEQHTERNFFLRMKCTLTSRGRTVNIKSATWKVLQCTGHIQ
VYETCK-GKTHCGYQEPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHTLDMKFSYCDERITELIGYQPEELLGRSVYVLYYALDSDHLTKTHHDLFTKG
QATSGQYRMLAKEGGYVWVETQATVIYNTKNSQPQCVVCVNYVLSGVVEKELVFSIGQAKKTVESVEAKITQLFSKIKP--A-EDSNSLFDQLKEEPEAL
TLLAPAAGDTIISLDFSKQQFDEVPLYNDVMLPSSSENLQN-CSSTDPTPEPLDLSFSVPQTQDRP-STPSEHHTSQSTP-PKSPPDYCFEVVSEFKLDL
VEKLFAIDTEPKSFFSTQ-EAEELDLEMLAPYIPMDD-DFQLRSFDQLSPLQSGSESPQ---NVGSVTNLFHQAQAPVSEKS-----TSA--------TK
EIEEIKT----VIQSPSHIN-SAPASPYSGNRSRTASPVRTGVQ---GSG---LAEPA-------DRSCPGTPNVSPVT----LNSRTITLNKELNPLTI
LL-HNVQRKRKLENEASLFQAVGI-TLSSGSN--AGCKRTKGIQSSPPNGPQQKT---------------------------------------------
--------------LILLSTDLASRLLERSED-NRLPQLTRYDCEVNAPIQDSRNLLQGEELLRALDQIN
>tr|U3JLA1|U3JLA1_FICAL Uncharacterized protein (Fragment) OS=Ficedula albicollis GN=HIF1A PE=4 SV=1
--------------------------------------------------------MRLTISYLRMRKLLD-AGEL-ETEAKMEKELNCFYLKALDGFVM
VLSEDGDMIYMSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTHRN--GPVKKGKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIR
VYDTCG-NQTHCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKG
QVTTGQYRMLAKQGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVQKDLIFSLGQTECMLKPVDMKMTKIFSKDD---L-DDTNSLFEKLKQEPDAL
TVLAPAAGDTIISLDFSSQQCDEVPLYNDVMLPSSSEKLQNIRSNADPNTEPLELSFTMPQVQEQP-TSPSDASTSQSSP-PSSPNDYCFDVASEFKLEL
VEKLFAIDTEAKNPFSTQ-ET-DLDLEMLAPYIPMDD-DFQLRSFDQLSPLESS-SSGS---PSAGSITMFQQSPPA-A-----------RAEEAKKA-A
ERDDAKAVAVPSARAAPEPG-GAPASPYGGSSSPTASPIRAG------KG---AVDQV-------EKPSPGAPSLLTVT----LNKRSTALDEELNPKML
AL-HNAQRKRKMEHDGSLFQAVGI-SLDSGGNASLAWKRVKGCKTNGHGGVEQKT---------------------------------------------
--------------IILLSTDIASKLLGQSMDESGLPQLTSYDCEVNAPIQGNRNLLQGEELLRALDQVN
>tr|K7FUG2|K7FUG2_PELSI Uncharacterized protein OS=Pelodiscus sinensis GN=HIF1A PE=4 SV=1
--------------------------------------------------------MRLTISYLRMRKLLD-SSDL-ETEAKMEKEMNCFYLKALDGFVM
VLSEDGDMIYMSENVNKCMGLTQFELTGHSVFDFTHPCDHEELKEMLTHRN--GLVKKGKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHVR
VYDTCN-NQTHCGYKKPPMTCLVLICVPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFAKG
QVTTGQYRMLAKHGGYVWVETQATVIYSTKNSQPQCIVCVNYVLSEIVQEELFFSLGQTERVLKPVEMNMTKIFSKAD---L-EDSNSLFEKLKKEPDAL
TLLAPAPGDTIVSLDFDSQQFDEVPLYNDVMLPSSSEKLQNIRSNADPNTEPLELAFSSRPRQEQP-SSPSDTSTNQSSP-PHSPNDYCFDVANEFKLEL
VEKLFAIDTEAKNPFSTQ-ET-DLDLEMLAPYIPMDD-DFQLRSFDQPPPLESGCANS-----QNVASTVFHQTQTI-S-----------AAEEIIPVKT
ECDDVKTLIVSQVLVINEID-STPASPYGGNRSRTASPIRAG------KG---TLEQT-------EKSYPGTPNLLTVT----LSNRSNPVDEELNPKML
AL-HNSQRKRKMEYDGSLFQAVGI-SLDCGTNAS-LWKRVKGCKSNGQNGVGQKT---------------------------------------------
--------------IILLSTDIASKLLGQSMDETGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
>tr|G1KSA4|G1KSA4_ANOCA Uncharacterized protein (Fragment) OS=Anolis carolinensis GN=HIF1A PE=4 SV=1
--------------------------------------------------------MRLTISYLRMRKLLD-AGDL-EAEAEMETQLNCFYLKALDGFVM
VLSEDGDMIYMSENVNKCMGLTQFDLTGHSVFDFTHPCDHEELREMLTHRN--GPVKKGKEQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIR
VYDNCN-NQTVCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELIGYDPEELLGRSIYEYYHALDSDHLTKTHHDMFAKG
QVTTGQYRMLAKQGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGVVQGDLIFSLQQTECMLKPVEMGVIKILDQTE---L-EDSNSLFEKLKKEPDAL
TYLAPAAGDTIIALDFDSQQFDEVPLYNDVMLPSSSEKLQSIRSSADPCTEPLDLSFSIRQTQDQP-ATPSDGSTSQSSPESSTPSDYCFDVASEFKLEL
VEKLFAIDPESKKPFSMQ-ET-DLDLEMLAPYIPMDD-DFQLRSFDQLSPLESSSASPP---SSGATVAGFQSTPVQLP------------PDKIPPMTI
KHEDSKTHT----HMPLETN-SVPASPYTDNSSRTASPVRTG------KG---TIEQK-------ENSSPGTPSLLTVT----LGSRSTAANEDINPKII
AL-HNIQRKRKMEQDGLLFQAVGI-TLTPGTNVSLAWKRVKGCKPNGQSEVAEKT---------------------------------------------
--------------VILLPSDIASKLLGQSMDEKGLPQLTSYDCEVNAPIQGNRNLLQGEELLKALDQVN
>tr|F6RGY6|F6RGY6_MONDO Uncharacterized protein OS=Monodelphis domestica GN=HIF1A PE=4 SV=1
--------------------------------------------------------MRLTISYLRMRKLLD-AGDL-EAEAEMEAQLNCFYLKALDGFVM
VLTEDGDMIYMSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLIHRN--GPVKKGKEQNTERSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIR
VYDTCN-NQSQCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKG
QVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIVQHDLIFSLGQTECMLKPVERKITELLTNVE---T-EDTSSLFEKLKKEPDAL
TLLAPAAGDTIISLDFDNEQQLEVPLYNDVMLPSSSEKLQNIRSNADPNPEPLELSFTMPQIQDHP-ASPSDASTRQSSP-PSSSSEYCFDVANEFKLEL
VEKLFAEDTEAKNPFSTQ-DT-DLDLEMLAPYIPMDD-DFQLRSFDQLSPLENTSTSSQ----SVSTLNIFQQSQTQEP-----------TSNEVKTVKT
EGDDNKILIASPVYVINETA-SAPASPYDGNRSRTASPDRAE------KG---VIEQM-------EKSHPRSPNLLSVT----LSYGTTALDEELNPKIL
AL-QNSQRKRKMEHEGSLFQAVGI-SLDPGTTISLSWKRVKGCKSNEQNGVEQKT---------------------------------------------
--------------VILIPSDLVSRLLGPSMDESGLPQLTSYDCEVNVPIQGNRNLLQGEELQRALDQVN
>tr|A0A0A7HSI3|A0A0A7HSI3_HETGA Hypoxia-inducible factor 1-alpha OS=Heterocephalus glaber PE=2 SV=1
--------------------------------------------------------MRLTISYLRVRKLLD-AGDL-DFEDEMKAQMNCFYLKALDGFVM
VLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMKEMLTHRN--GPVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIH
VYDTNN-NQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKG
QVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVEMKITQLFTKVE---S-EDTSSLFDKLKKEPDAL
TLLAPAAGDIIISLDFSSQQLEEVPLYNDVMFPSSSEKLQNIRSSADPNPESLELSFTMPQIQDQP-ASPSDGSTRQSSPEPNSPSDYCFDVVNVFKLEL
VEKLFAEDTEAKNPFSTQ-DN-DLDLEMLAPYIPMDD-DFQLRSFDQLSPLESSSASPQ----SVSTTTVFQQTQMQEPTTTTANTT-PPTTEELKSVTK
DSEDIQILIVSPTHLLKETAHATTSSPYSNTPSRTTSPNRAG------KG---AIEQT-------EKSHPRSPNVVPVT----LSQRNTIPEEELNPKIQ
AL-QNAQRKRKMEHDGSLFQAVGIGTLDRAATTSLSWKRVKGCKSSEQNGTEQKT---------------------------------------------
--------------IILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
>sp|O35800|HIF1A_RAT Hypoxia-inducible factor 1-alpha OS=Rattus norvegicus GN=Hif1a PE=2 SV=1
--------------------------------------------------------MRLTISYLRVRKLLD-AGDL-DIEDEMKAQMNCFYLKAPDGFVM
VLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRN--GPVRKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIH
VYDTSS-NQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKG
QVTTGQYRMLAKRGGYVWVETQATVIYNTKDSQPQCIVCVNYVVSGIIQHDLIFSLQQTESVLKPVEMKMTQLFTKVE---S-EDTSCLFDKLKKEPDAL
TLLAPAAGDTIISLDFGSQQLEDVPLYNDVMFPSSNEKL-NIRSSADPSPESLGLSFTMPQIQDQP-ASPSDGSTRQSSPEPNSPSEYCFDVVNVFKLEL
VEKLFAEDTEAKNPFSAQ-DT-DLDLEMLAPYIPMDD-DFQLRSFDQLSPLESNSPSPP----SVSTVTGFQQTQLQKPTVTAATATTATTTDESKAVTK
DNEDIKILIASPTQVPQEMTTAKASAYSG-THSRTASPDRAG------KR---VIEKT-------DKAHPRSLNL-SVT----LNQRNTVPEEELNPRTI
AL-QNAQRKRKMEHDGSLFQAAGIGTLDRAPTMSLSWKRVKGYISSEQDGMEQKT---------------------------------------------
--------------IFLIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
>tr|T1Q049|T1Q049_9ACTI Hypoxia-inducible factor 1 alpha subunit OS=Lepisosteus platostomus PE=2 SV=1
--------------------------------------------------------MRLTISYLRMRKLLSTAGDM-EEESEMDSQLNSFYLKALDGFLM
VLSEDGDMIYLSENVNKCMGLTQFDLTGHSVFDFTHPCDHEEMREMLTYRT--GSLKKAKEQNSERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIQ
VYESSD-GHNNCGYKEPPMTYLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYQPEDLLGRSVYEYYHALDSDHLTKTHHDLFAKG
QATTGQYRMLAKKGGFVWVETQATVIYNTKNSQPQCIVCVNYVLSGVVQEDLVFSLGQTESVLKPLEVEMPKIFTKAED--L-ESSNTLFEKLKEEPEAL
TLLAPAAGDTIISLDFTSQPLEEVPLYNDVMLPSSSEK----NSSLDPSADPPSFSFSIPRTQDSD-SSPSGTSTRQNSP-PSSPGDYCFQVGSEFKLDL
VEKLFAIDTEAKTPFATQ-TMDDLDLEMLAPYIPMDD-DFQLRTLDPLSPSETLSASAP---VMPSMSNVFQQIQTKPQS-------------TDTPMPT
AGEEVK---RAALHLVQEVR-NALNSPFSGSRSRTSSPAPSSTH---STS---GREQT-------DSPHSAT-------------RRIPALEGALSPKML
AI-QNAQRKRKLETGTSLSQAVGI-TLN----PAAIEKRAKVFETSGKEALTHKT---------------------------------------------
--------------ILLLPTDLASRLLECSFGSDGLPQLTRYDCEVNAPVQGRQHLLQGEELLRALDQVN
>tr|S7N5Y1|S7N5Y1_MYOBR Hypoxia-inducible factor 1-alpha OS=Myotis brandtii GN=D623_10027172 PE=4 SV=1
--------------------------------------------------------MRLTISYLRVRKLLD-AGDL-DIEDEMKAQMNCFYLKALDGFVM
VLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRN--GLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIH
VYDTNG-NQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKG
QVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNFVVSGIIQHDLIFSLQQTECVLKPVEMKMTQLFTKVE---S-EDTSSLFDKLKKEPDAL
TLLAPAAGDTIISLDFGSQQLEEVPLYNDVMLPSSNEKLQSIRSSADPNPESLELSFTMPQIQDQP-ASPSDGSTRQSSPEPTSPSEYCFDVVNEFKLEL
VEKLFAEDTEAKNPFSTQ-DT-DLDLEMLAPYIPMDD-DFQLRSFDQLSPLESSSTSPQ----SASTVTVFQLTQMEEPTTTT----TTATTDELKTLTK
DGEDIKILIASPTH-VPKETSSTTTSPYSDNRSRTASPNRAG------KG---VIEQT-------EKSHPRSPNVLSIT----LSQRTTVPEEELNPKIL
AL-QNAQRKRKIEHDGSLFQAVGI-GQGPGLGRGPGMERVQAGLRGHPHTRPMHE---------------------------------------------
--------------FQHRASNLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
>tr|T1Q069|T1Q069_PROAN Hypoxia-inducible factor 1 alpha subunit OS=Protopterus annectens PE=2 SV=1
--------------------------------------------------------MRLVISYLRMRALLSTSN-I--EDDESDKQLNSFYLKALDGFVM
VLTEDGDMIYLSENVNRCIGLTQFELTGHSVFDFMHPCDHEELREMLTHRI--GPVKKGKGQSTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCSGHIR
VYESGS-DQTHCGFKEPPLTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELMGYDPEDLLNHSVYEYYHALDSDNLTKTHHDLFTKG
QVTTGQYRMLAKEGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVEKGLIFSVEQTKSLMKSVPADKTKHLS------T-ENPGHLFEKLKEEPEAL
TLLAPAPGDTIIPLDFNNQSLDSVALYDDVMLSSDEKV--HSQSDTDPPPEPLGLSFTVAQTQKQP-NSPSDPSASQNST-PSSPSDYCFRVDNEFKLDL
VEKLFAVDTEAKNPFSAQ-VE-GLDLEMLAPYISMDD-DYQLRSFDQLPPLESDSVDEN---MAGSVTPVFQPTLAPAC-------------NEAIMMTP
EISYVSKSVSPQIRVIREIS-SAPTSPYSASRSRTSSPVRTNAQ---GKG---PTEHL-------DRSRPGTPVTSPVL----Q-HRAASSDQELSPKML
AL-QNVQRKRKMENEGSLFTAAGI-AL---MNNSSTRKRVKGYESSGRNE-EQMT---------------------------------------------
--------------LLLSSTDLASRLLGQSVESSKLPQLTSYDCEVNAPIQGNKNLLQGEDLLKALDQVN
>tr|B3FMV7|B3FMV7_RANTE Hypoxia-inducible factor 1 alpha OS=Rana temporaria GN=HIF-1a PE=2 SV=1
--------------------------------------------------------MRLTISYLRIRRLLD-AGDM-DGESEMEKQLNCFYLKALEGFVL
VLTEEGDMIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTFRN--GPSKKGKEQITERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHMR
VYDGCN-SQNHCGYKKPPMTCMVLICEPIPHPSNIEFPLDSKTFLSRHSLDMKFSYCDERVTELAGYEPDELLGQSVYDYYHALDSDHLTKAHHDMFTKG
QVTTGQYRMLAKKGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSDIVEKELILSLGQTESTLVSSESKMPQFFTKLAD--E-EDANVLYEQLKKAPEFL
NVLAPDAGDEIIPLDFSSSQYDDAPLYNDVMLHSTSKPPENIRSNADPSSEQLGLAFTIPQLS-KP-SSPSEISSNQSST-PGTPAEYCFDEAPEFKMDL
VEKLFAMDTEAKAPFSTQ-ET-DLDLEMLAPYIPMDD-DFQLRSFDQLSSMETDSAPIQ---SLGSMTNLFPPSTASSS--------------DLKPITT
EASDPKTII--HTPTNKEAL-SAPASPYNGNRSRTSSPVRTD------KA---AVK---------ERSRPGTPTITSP-------KRPAVLDDELSPKMI
AL-HNVQRKRKIESDGPLFQAVGL-TIDPGSNSPLLWKCVKVSDSDKPTGPEQRT---------------------------------------------
--------------ILLLSTDMASRLLGQSLDGTGLPQLTGYDCEVNAPIQGNRNLLQGEDLLKALDQAN
>tr|V9KA26|V9KA26_CALMI Hypoxia-inducible factor 1 alpha OS=Callorhynchus milii PE=2 SV=1
--------------------------------------------------------MRLTISYLRMRKLLSP-RDV-EVEPDREKQLNSFYLKALEGFVL
VLTQDGDMIYMSENVNKYMGLTQFELIGHSIFDFTHPCDHEEMREMLSHRQG-LQ-KKGKDQITERSFFLRMKCTLTSRGRTVNIKSSSWKVLHCTGHIQ
VHEG-S-DQTPCGYKEPPMTCLALVCEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDER-TELMGYQPDELLGRSVYEYYHAMDSDHLTKTHHDLFSKG
QATTCQYRMLSKEGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGVVEKGVVFSLDQTESVPVTDETTG--KSYNS----P-TESNDLFNKLKEEPEAL
TQLAPAAGDTIISLDFSP-EMQHFPLYNDVMLPSSTEQKPV-NL----NPESLELSFTIPQMKEQP-NS----------PSPSSPSEYCYNVSNVFKLDI
VEKLFAVDPEAKNPFSVQ-DVDGLDLEMLAPYIPMDD-DFQLRSLDQLSPLTDIQASPPHSQSVSSIVNLFQSAPKSAKTEKYAPLKISL-----E----
NTSLSASQSSP-LHMMDEVS-STPGSPYSKPTSRTASPVRTSGKGLSE--------QM-------DASRSGSP------MSPVLTAAGGNLQEEVDAKLL
SL-HNLQRKRKIENAASLFQAAGI-LLIP---APQIWKRAKRSDT-T----KEKT---------------------------------------------
--------------LAS--TDTVSRLLMHSSETRKLPTLTSYDCEVNAPIQNNRNLLQGEDVLRALDQVN
>tr|V8NR02|V8NR02_OPHHA Hypoxia-inducible factor 1-alpha OS=Ophiophagus hannah GN=HIF1A PE=4 SV=1
--------------------------------------------------------MRLTISYLRMRKLLD-ADDL-EAEAEMETQLNCFYLKALDGFVM
VLSEDGDMIYTSENVNKCMGLTQFELTGHR------------------------SVKKGKDQNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIR
VYENCN-NQNVCGYKKPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDERITELIGYDHEELLGHSVYEYYHALDSDHLTKTHHDMFAKG
QVTTGQYRMLAKQGGYVWVETQATVIYNTKNSQPQCIVCVNYVLSGIVQGDLVFSLQQTERMLKPVDMGMMKVLNKSD---V-EDSSSLFEKLKKEPDAL
AYLAPAAGDTIIALDFDNQPSDDVPLYNDVMLPSSSEKLQNICSSADPSTEPLDLTFSSRRTQDQP-ATPSDGSTSQSSPENSPPNDYCFSMSSEFKLEL
VEKLFAIDPESKNPFSMQ-ET-DLDLEMLAPYIPMDD-DFQLRTFDQLSPLEGNTASPS---SSVTPVTGFQQTPMQSL------------TDTMKSTTI
KHTAPKMLVINPLPDPAPII-SAPTSPYAKNESRTSSPIRTG------KG---TIDQT-------DQMSPGAPDLLTVT----FG-RSPEVNEDISPRII
AL-HNIQRKRKMEQDGLLFQAVGI-TLPPGTNISLAWKRVKGCRSNRQNEVAEKT---------------------------------------------
--------------VILLPSDIASKLLGQSMDEKGLPQLTSYDCEVNAPIQGNRNLLQGEELFRALDQIN
>tr|B4Y034|B4Y034_MUSCA Hypoxia-inducible factor 1 alpha OS=Mustelus canis GN=HIF-1a PE=2 SV=1
--------------------------------------------------------MRLTISYLRMRKLLDA-GNA-EIEADVEKHLNSFYLKALEGFVM
VLTQDGDMIYMSENVNKCVGLTQFELIGHSVFDFTHPCDHEEMREMLSHRQG-PL-KKGKDQNTERNFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIR
VYKS-N-NQTHCGYKEPPMTCLVLICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDER-TELMGYQPEELLGRSVYEFYHAMDSDHLTKTHHDLFTKG
QATTGQYRMLGKEGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSGLVEKEVVLSLDQTECAPVSDE--S--KSPVS----S-TKADNLFDKLKEEPEAL
TQLAPAAGDTVVSLDFSPQPFKEVPLYNDVMLPSSTNQKTV-NL----NQESLEFSFTIPQMNEQP-SS----------SSPSSPSDYCFNVSNEFKLDI
VEKLFAIDPEAKHPFSVQ-DINDLDLEMLAPYIPMDD-DFQLRSLDQTSPLADSQTTSTKTPSLNTMVGVFSDTGTSDNPDKHMPLKKTM-----E----
NIPPVATKSSL---RTNQIV-STPGSPQNEKSSRTASPVRTGGKEITQ--------QT-------DTSHPQST------MSSLLTATREAPNEDLSPMVL
LL-HNSPRKRKLENAASLFQAVGI-LLDP---TSQTWKRAKEFDA-N----EQKT---------------------------------------------
--------------LVL--TDIVTRLLTHSAEGSSLPTLTNYDCEVNAPIQGNRTLLQGEEVLRALDQVN
>tr|B7SCS8|B7SCS8_9CHON Hypoxia-inducible factor 1 alpha OS=Hemiscyllium ocellatum GN=HIF-1a PE=2 SV=1
--------------------------------------------------------MRLTISYLRMRKLLNA-GDM-EVEADLEEQLNSFYLKALEGFVM
VLTQDGDMIYMSENVNKCMGLTQFELIGHSVFDFTHPCDHEEMREMLSHRQG-LL-KKGKDQNTERNFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHIR
VYKS-S-NQTHCGYKEPPMTCLILICEPIPHPSNIEVPLDSKTFLSRHSLDMKFSYCDER-TELMGYQAEELLGRSVYEFYHALDSDHLTKTHHDLFTKG
QATTGQYRMLGKEGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSGLVEKEVILSLDQIECVPVE----S--KHPVS----S-TETNNLFDKLKEEPEAL
TQLAPAAGDTVVSLDFNPQQFNEVPLYNDVMLPSSTNQKTV-NL----NQESMEFSFAIPQMNEQS-SS----------SSPSSPSDYCFNVSNEFKLDI
VEKLFAIDPEAKHPFSVQ-DIDNLDLEMLAPYIPMDD-DFQLRSLDQLSPFSDCQTTPTSTPNVNAMVDI-SEAGTSVNPNKYMSLKNTG-----K----
NDSSAATKPTP---HTIKRD-NGPSSSQNKKSNRTTSPVRTGIQKLTQ--------QM-------DISRPQSS------LSALLAAIGEAPKEELSPQLL
IL-HNSPRKRKLENAASLFQAVGI-LLDA---TSQTWKRAKGLED-S----EQKT---------------------------------------------
--------------LVL--TDIVSRLLTHSAESSSLPTLTNYDCEVNAPIQGNRTLLQGEEVLRALDQIN
>tr|T1Q067|T1Q067_POLSE Hypoxia-inducible factor 1 alpha subunit OS=Polypterus senegalus PE=2 SV=1
--------------------------------------------------------MRLTISYLRVRKLLSQATEK-LEESELDSQMNCFYLKALEGFVM
VLSEDGDMVYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREVLTHRAG-AA-KKGKEVNTERSFFLRMKCTLTSRGRTVNIKSATWKVLHCLGHIR
AYES-C-EQNDCGYKKPLVTSLVVICEPIPHPSNIEVPLDSKTFLSRHSLEMKFSYCDER-TELMGYQPEDLLGRSVYEYYHAMDSDHLTKTHHNLFAKG
QATTGQYRMLAKNGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSGVVEKDLIFSLSQTETLPVKAITVK--VTGKT----V-PDGDSLFDKLKEEPEAL
TVLAPAAGDTIISLDFSTSSFEEVPLYNDVMLPSPNE-----NL----NAEPLELSFSIPQIHNSR-TS----------SSPNSPVDYSFEVSSEFKLDL
VEKLFAIDTEAKTSFVSQ-AGDDLDLEMLAPYIPMDD-DFQLRTMDQMSPMESLPSNPLIMENMNSL---FQPAETSASSNTETFLNTVE-----K----
NT--KPLLRSP-LHMIHNVQ-SLSDSSFSIQTNEAASLLNNSPSALDR--------HC-------N-QSSIQT------L---L-KTICTLDEELSPRTC
-----AQRKRKLQIADSLSKALEI-SVD----SVGAWKRAKACKA-S----KHKT---------------------------------------------
--------------IIL--TDLASRLLASSFESSGLPQLTRYDCEVNAPLQGRQNLLQGEELLRALDQVN
>sp|Q9I8A9|HIF1A_XENLA Hypoxia-inducible factor 1-alpha OS=Xenopus laevis GN=hif1a PE=2 SV=1
--------------------------------------------------------MRLDHQLPAVEKVADA-GDL-DGETELDKQLNCFYLKALEGFVL
VLTEEGDMIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTFRNG-PA-KKRKRTNHREKFLPSYEMYINQ-----SWKNREYKVSHMEGHAC
IYDN-A-NQNHCGYKKPPMTCMVVICEPIPHPSNIEFPLDSKTFLSRHSLDMKFSYCDER-TELVGYEPDELLGRSVYEYYHALDSDHLTKPNYNMFTKG
QVTTGQYRMLAKKGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSEVVEKDLILSLGQTASVLI-PVMPE--IFTEL----N-ENSECLFDKLKQEPESL
TVLAPDAGDEIIPLDFSSKPYEDVPLYNDVMLHSTSNKL-E-NR----NPRTTCASIHHSTAIQAR-QP----------FRPN-TPEYCFDVASEFKLDL
VEKLFAIDTEAKAPFYY--PGNDLDLEMLAPYIPMDD-DFQLRTFDQLSSLECDSSIPQT-LGSM--TTLFHQSLSPS---TSDFPEDAM-----S----
----DLKTISP-VHMMKEST-SAPVSPYNGNRSRTSSPVRPAKAV-VD--------KT-------EKSRPGTP------NLPL--KRCTILDEELNPKMI
CFTQCTAEKRKMESDGPLFQAIGI-TLDP---SSLQWKRVKGSDS-E----EQRT---------------------------------------------
--------------ILL--TDMASQLLGQSFDGTVLPQLTGYDCEVNAPVHGTRNLLQGEELLRALDQAN
>tr|V9KF35|V9KF35_CALMI Hypoxia-inducible factor 2 alpha OS=Callorhynchus milii PE=2 SV=1
--------------------------------------------------------MRLTISFLRTRKLLTSGLEN---ETDSERQMDSLYLKALEGFIT
VVTQDGDIIFLSENVNKHMGIAQVELTGHSIFDFTHPCDHEEIRENLTLKNAPGFGKKNKDLNTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGHIK
MYNTCL--HTLCGYKEPPLTCLIMMCEPIQHPSNIDVPLDSKTFLSRHSMDMKFTYCDERVTTLMGYHPEELLGRSVYEFYHALDSDHMTKSHQNLCTKG
QAVTGQYRMLAKHGGYVWVETQGTVIYNSRNSQPQCIVCVNYVLSDVEEKNVMFSMDQTESLFKPCLRNV--NGRYING-AS-VDSELLFSKLKEEPEEL
AQLAPTAGDAIISLDFGI-QLEKTSLYNK---GAMPP-----LT----PP-LDLHSFVVPRVTSG-----------NATPSPSSPGDYY---DNDLKIEL
TEKLFSMDTQ------QV-ELSDLDLETLAPYIPMDE-DFQLSPICCEEPPTSENTSETQ-KCCTNINSLFQPLAPNSV-SSLISCTTLKKSNF------
---------T--HIPPLPQYHGSVNTPVSSMGGRPSIQWPPDPHFGTFFG---TPSGH-------PAHLQSLYKQ-PLQCVKS--FG--QHGKDISPALT
AFTNNLKRKRQLEFGEL-SLSAEC----R---AQFLWKRMKAIKCET-----------------------------------------------------
-------------------TGMASRLLGSSFVSYSLPELTRYDCEVNAPVVGNSTLLQGRELLRALDQAT
>tr|H2ZZT4|H2ZZT4_LATCH Uncharacterized protein OS=Latimeria chalumnae GN=EPAS1 PE=4 SV=1
--------------------------------------------------------MRLTISFLRIHKLLSSACPDDE--TETDNQMDNFYLKSLEGFIA
VVTQDGDMIFLSENINKYMGLTQVELTGHSIFDYTHPCDHEEIRENLSLKTGSGFGKKNKDINTERDFFMRMKCTVTNRGRTVNLKSATWKVLRCTGHIK
VYNACH-PH-MCGYKEPLLTCLIMMCQPIPHPSNIDIPLDSKTFLSRHSMDMKFTYCDERITELVGYHPEELLGHSAYEFYHALDSENMTKSHQNLCAKG
QAISGQYRMLAKHGGYVWLETQGTVIYNTRNSQPQCIVCVNFVLSKIEDNDVVFSMDQTESLFKPHL-TMNSIFSNS-I--L-MKGELLFTKLKEEPEEL
AQLAPTPGDAIISLEF--QKFEEASLY---VM-----------------EVANLSTFTVPQVP-SG-CSTPSA--------PSSPGDYY---DNNLKVEL
IEKLFAMDTESKSPCNQA-DFNELDLETLAPYIPMDE-DFQLNPICQDEQPPSDNPQNTQ-QPFSNMAALFQ---PTIPQSQLITIQRAA---SEK-NNH
SPPPVAQSPYNRKNVALSPYHAPASIPLSPMGCQPDIQWPPDPPFSGSLP---G------------SQPGS-PVH-TLYKKRS--FGQ-HGED-LNPVFT
AL-NNFKRKRQLDFG-QRFQQI-Q--G-G---LQIIWKRMKGIKGE--QNLNYRE---------------------------------------------
--------------FSM-LKGMASRLLGPSFETYSLPELTRYDCEVNAPVLGYSKLLQGSELLRALDQAT
>tr|Q9W7C6|Q9W7C6_CHICK Endothelial PAS domain protein 1 OS=Gallus gallus GN=EPAS1 PE=2 SV=1
--------------------------------------------------------MRLAISFLRTHKLLSSVCADNENELEADQQMDNLYLKALEGFIA
VVTQDGDMIFLSENVNKYMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGPGFGKKNKEMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVK
VYNTCP-PHTLCGYKEPLLTCLIIMCEPIQHPSNIDIPLDSKTFMSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVTGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIICVNYVLSEIEKNDIVFSMDQTESLFKPHL-TMSSAFENG-I--S-GKSDLLFTKLKEEPEEL
AQLAPTPGDAIISLDFELQKFEEAPAY---AV-----------------ETLTIPSFTMPQIA-PG-SSTPSA---------NSPEDYY---DDDLKIEV
IEKLFAMDTESKSQCNQT-DFNELDLETLAPYIPMDE-DFQLSPICQEERTLSESAQNTQ-QSLSSMSTIFQPLA---SQNQFLPPQLSN---KNINP-G
---HGSLSSFNNSRSSLPPYHNQASTPLSSMGGRPNTQWPPDPPLSGTLS---S------------SPSGP-PVR-PIYKKRP--LGQ-RGID-INPARI
ALSNSLKLKRQLDYE-QALQQL-S----V---PQLMWKRMKFLKGE--ESPHYQD---------------------------------------------
--------------YTVQSSGVTSRLLGSSFEPYLLPELTRYDCEVNVPVLGSSTLLQGSELLRALDQAT
>tr|H9G8J6|H9G8J6_ANOCA Uncharacterized protein OS=Anolis carolinensis GN=EPAS1 PE=4 SV=2
--------------------------------------------------------MRLAISFLRTHKLLSSVCTENKKEIESDQQMDNLYLKALEGFIT
VITQDGDMIFLSENISKYMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGPGFGKKNKEMSMERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQIK
VYNTCP-PHALCGYKEPLLSCLVLMCEPIQHPSNTDIPLDSKTFLSRHSMDMKFTYCDDRITELVGYHPDELLGRSAYEFYHALDSENMTKSHQNLCAKG
QVVTGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIICVNYVLSEIENNDIVFSMDQTESLFKPRM-AMNSVYDNG-I--P-VKSDFLFTKLKEEPEEL
AQLAPTPGDAIISLDF--QKFEEISTY---AV-----------------EKLSVPSFTLPQVA-PG-STTPSA---------SSPGDYY---DEDLKIEM
IEKLFAMDTNAKNQCSQT-DFNELDLETLAPYIPMDE-DFQLSPICQEERPLSENAQLTQ-QSLSNMNSLFQPLA---PQNQFLLPQMSD---KNINT-G
---QGTLPPFNNQSASLLPYYAQATTPLSSMGGRPNTQWPPDPPLSKSMA---S------------TPSGP-PLH-NLYKKRS--FGQ-RGID-INPARI
ALANSLKLKRHLEYE-QAFQHL-N-PQ-G---THLMWKRMKILRGE--NNPPYQD---------------------------------------------
--------------FSVPQSGMTSRLLGSSFEPYLLPELTRYDCEVNVPMVGSSMLLQGSDLLRALDQAT
>tr|T1Q070|T1Q070_ACISI Hypoxia-inducible factor 2 alpha subunit OS=Acipenser sinensis PE=2 SV=1
--------------------------------------------------------MRLAISFLRTRKLVSSIWPDNE--SESDKQMDGLYLKALEGFIA
VVTQDGDMIFLSENINKIMGLTQVELTGHSIFDFTHPCDHDEMRENLSLRNGLGFGKKNKDLNTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQVK
VYNSCP-PHTLCGFKEPPLTCVVMMCEPIPHPSNIDMPLDSKTFLSRHSMDMKFTYCDERVTELMGYWPEELLGRSVYEFYHALDSDRMTKSHQNLCTKG
QAVSSQYRMLAKHGGYVWVETQGTVIYNTRNSHPQCIVCVNFVLSDIEENSVIFSLDQTESLLKPHV-SMNSFFNSG-V--P-AASEQLFTRLKEEPEEL
AQLAPTPGDTIISLDF--PPFEEAPLY---VM-----------------EGKSLAAFSVPQGS-PA-R---TP--------PSSPGDYY---DNDLKVEL
TEKLFAMDTAAKAQCTEL-ELNDLDLETLAPYIPMDE-DFQLNPICQEEPPLSENSDNSSSHSFSTIASLFQ---PLASPSHVLSAPMHP---SAQKRNP
SPAPDPRTPYMG--TLVPFYHTPTSTPLSSMGGRQNVQWPPDPPFLPG------------------CQS-------SLYKQRS--FFE-QGKD-VTPART
AVASHYKRKRQAEYR-QPLFQQ-L--L-S---PEMMWKRMKALKAD--EGPNYRE---------------------------------------------
--------------FNM-LMGMASRLLGPSFETYSLPELTRYDCEVNVPVLGNLNLLQGGDLLRALDQAS
>tr|K7G1Q3|K7G1Q3_PELSI Uncharacterized protein OS=Pelodiscus sinensis GN=EPAS1 PE=4 SV=1
--------------------------------------------------------MRLAISFLRTHKLLSSVCVDNESDLDIDQQIDNLYLKALEGFIA
VVTQDGDMIFLSENINKYMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKTGPGFGKKNKEMSTDRDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVK
VYNSCP-SHSLCGYKEPLLTCLIIMCEPIQHPSNMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCAKG
QIVTGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIVCVNYVLSEIEKNDIVFSMDQTESLFKPHL-TMNTIFDNG-V--P-VKSDFLFTKLKEEPEEL
AQLAPTPGDAIISLDFAQQKFEEASIY---AV-----------------ETMTMPSFTMPQVA-PG-SSTPSA--------PSSPGDCY---DEDLKIEM
IEKLFAMDTESKNQCNQT-DFNELDLETLAPYIPMDE-DFQLSPICQEERPLPENAPNTQ-QSLRSMSAIFQPLA---PQNEFLLQQISN---KNTNP-N
---HGPLSSFNSSKSSLPPYHVRGSTPLASMVGRPGTQWPPDPPLYGSLA---S------------SSSGP-PVH-SLYKKRS--FEQ-HGID-INPART
ALANSLKLKRQMDYE-QIFQQR-T----T---SHLMWKRMKILKGE--ESSHYQN---------------------------------------------
--------------FNVQPSGVTSRLLGQSYEPYLLPELTRYDCEVNVPVLGSSTLLQGSDLLRALDQAT
>tr|W5NHS9|W5NHS9_LEPOC Uncharacterized protein OS=Lepisosteus oculatus PE=4 SV=1
--------------------------------------------------------MRLTISFLRTRKLLSSTWPDNV--SEADRQMDSLYLKALDGFIA
VVTQDGDMIFLSENINKFLGLTQVELTGHSIFDFTHPCDHDEIRENLSFKPGQGFGKKNKDLNTERDFFMRMKCTVTSRGRTVNLKSASWKVLHCTGHLK
VYNSCP-PHVLCGFKEPPLTCVIMMCVPIPHPSNIDMPLDSKTFLSRHSMDMKFTYCDDRVTELMGYCPEDLLGRSVYEFYHALDSDSMTKSHQNLCTKG
QAISGQYRMLAKHGGYVWVESQGTVIYNSRNSQPQCIVCVNYVLSEIEESLVLFSMDQTESLFKPHV-SMGSFFSNG-A--A-ASSELLFTKLKEEPEDL
AQLAPTPGDAIIALDF--PQYEEAQMY---AM-----------------EVPSVAAFSVTQPP-PG-STTPSL--------PSSPGDYY---DNELKVEL
TERLFALDTDPKSPYTQS-EVSDLDLETLAPYIPMDE-DFQLNPICQDEVPLPDSSPSSTHHSFSNIANLFQ---PLSSPGQFC---------SAEKRNS
SSSPDPRPAYPA--TVMPPYHTPSSTPLSSMGGRQNLQWPPDPPFRPS------------------NQGPQ-PLP-PLYKQRS--FVQ-PQKD-MSPSRI
ALVNSFKRKRLLELA-QHPFQP-L--P-G---SEMIWKRMRNLKTE--TGTSYRE---------------------------------------------
--------------YSM-PEGMVSWLLGPSFESYSLPELTRYDCEVNIPLQGNLNLLQGSDLLRALDQAT
>tr|T1Q051|T1Q051_POLSP Hypoxia-inducible factor 2 alpha subunit OS=Polyodon spathula PE=2 SV=1
--------------------------------------------------------MRLAISFLRTRKLVSSTWPGN--ESKSDKQMDGLYLKALEGFIA
VVTQDGDMIFISENINKIMGLTQVELTGHSIFDFTHPCDHEEMRENLSLRNGLG--KKIKDLNTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQVK
VYNSCP--HTLCGFKEPPLTCVVMICEPIPHPSNIDMPLDSKTFLSRHTMDLKFTYCDERITELMGYCPEELLGRSVYEFYHALDSDSMTKSHQNLCTKG
QAVSSQYRMLAKHGGYVWLETQGTVIYNTRNSQPQCIVCVNFVLSDIEENSVIFSLDQTESLLKPHVMNS--FFNS--G-VP-VTSEQLFTSLKEEPEEL
AQLAPTPGDTIVSLDFGG-PFEDAPLYKT----IIPP-----SQ----EG-KSLATFSALQGSPA-----------RTPLSPSSPGDYY---DNDLKVER
TEKLFAMETA------EL-ELNDLDLETLAPYIPMDE-DFQLNPICQEEPPLSENSANSSSHSFSTVASLFQPLALPLH----SHCAPMQPSTEKRNPSP
AAGPHTP-LT--GTTLVPPYHTHTSTPLSSMGGIQNVQWPPDPPFACQ-------------------S------H-SLYNQRS--FF--QQGKDVTPART
ALASHYKRKRQTEYRDL-LQQLLM----S---PEMMWKRMKALKADS-GGSNYRE---------------------------------------------
--------------FNMLP-GMASRLLGPSFETYSLPELTRYDCEVNVPVLSNLNLLQGGDLLRALDQAS
>tr|F6VTD1|F6VTD1_XENTR Uncharacterized protein (Fragment) OS=Xenopus tropicalis GN=epas1 PE=4 SV=1
--------------------------------------------------------MRLTISFLRTHKLLSSVCADRNIETASEKQLDNLYLKALEGFVA
VVTQDGDMIFLSENVNKYLGLTQVELTGHSIFDFTHPCDHDEIKENLSMKTGVGSGKKNKDANTEHDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGHVK
AYNSYY-PHSLCGYKEPVLSCLIMMCQPIQHPSNIDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSESMTKSHQNLCAKG
QVVTGQYRMLAKHGGYLWVETQSTVIYNTRNSQPQCIVCVNYVLSEIEKNDVVFSMDQTESLFKPHL-TMNSIFSSS-V-----KSDFLFTKLKKEPEDL
AQLAPTPGDEIVSLDF--QTFDEQSNF---VQ-----------------DIINLPSFKAPQVS-TG-NSTPSA--------PSSPEAYY---DEDLKIEL
IEKLFAMDTEAKNQCNQN-DFNDLDLETLAPYIPMDE-DFQLNPICQEESTISDTPQKAQ-QNLSSISSLFQ---PSTPQNQFLQQTTAA---KSNNGSQ
DPPSV----NNEKALPLTPYHTGASPPLSSVGGRPNVQWPPDPPVNGSLS---S------------LPSGP-PVH-PLYKQRS--FGQ-RGKD-LHPAEI
PFCNSMKRKRQLDYG-QGFPQL-D--V-G---PLIMWKRMKALKSG---SCSYHD---------------------------------------------
--------------YNM-QKGLTSRLIAPSFEPYLLPELTRYDCEVNVPVLGSSTLLQGSDLLRALDQTT
>tr|F7F7N2|F7F7N2_MONDO Uncharacterized protein OS=Monodelphis domestica GN=EPAS1 PE=4 SV=1
--------------------------------------------------------MRLAISFLRTHKLLSSVCTENETEVETDQQMDNLYLKALEGFIA
VVTQDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKSGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVK
VYNSCA-PHSLCGYKEPLLTCLIVMCEPIQHPSTMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSESMTKSHQNLCTKG
QVISGQYRMLAKHGGYVWLETQGTVIYNTRNLQPQCIICVNYVLSEIEKNDVVFSMDQTESLFKPHL-AMNNIFDT--E-IP-VKSNFLFAKLKEEPEEL
AQLAPTPGDAIISLDFG-QSFEESSTY---LL-----------------EA----SFTVPQMAPPG-STTPSA--------PSSPGDYY---DENLKMEM
IEKLFAMDTESKNQCNQT-DFNELDLETLAPYIPMDE-DFQLSPICQEERPQLENTQPSPQPNFSTMSSIFQPLAPTS-QSPFMLQQMES---KKSDVDP
----QPMSFFDGSKMTLPPCYGPASTPLSSMGGRSNTQWPPDPPLAKSL--------R-------RSPSGP-PLP-SMYKKSL--LGP-RGPDKMNPAVI
ALSNKLKMKRQLEYE-QNFQDM-S--G-G---PHLMWKRMKSLKGG--EAPAYQD---------------------------------------------
--------------YNP-PSGMTSRLLGPSFEPYLLPELTRYDCEVNVPVPGSSTLLQGSELLRALDQAT
>tr|T1Q050|T1Q050_POLSE Hypoxia-inducible factor 2 alpha subunit OS=Polypterus senegalus PE=2 SV=1
--------------------------------------------------------MRLTISFLRTRKLLSSTIPSS--DSGSDKYIDSLYLKTLDGFIA
VVTQDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSPKHGPGFSKKNREASSVRDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLK
MYNSHH--HTLCGFKEPPLNCVIMICEPIPHPINIDIPLDSKTYLSRHSMDMKFTYCDERITELMGYSPEELLGRSIYDFYHALDSDSLTKSHHNLCTKG
QAVSGQYRMLAKHGGYVWIETQGTVIYNSRNSQPQCIVCINYVLSEIEEDSIIFSMDQTESLFKPHVMSN--FFSS--G-MP-TSSELLFTKLKEEPEEL
AQLAPTPGDAIISLDFGA-PFDEPPIFNQ---KAIHP-----SH----EA-NNLGAFIVPQGAPG-----------SCTPSPSSPGDYY---DSELKVEL
TEKLFAMDTE------QP-ELSDLDLETLAPYIPMDE-DFQLNPICQEEHPLVEKPPSNRNPSFSNVTSLFQPLV--------SDCSVFAPPNEKPTSNT
VPRPHTL-LA--GSNVAPPYLTPSSTPLSSMGGRQNIQWPPDPPFGIT-------------------AHQ--PHH-SVYKQRS--FF--HQNKEMIAVQQ
DFISSFKRKRHLEFSQA-FQEEAL----P-----ATWKKLKAVKAEN-AGPGYRE---------------------------------------------
--------------FTVLPEGMATRLLGPTFDSYSLPELTRYDCEVNVPLHGHLNLLQGSDLLRALDQGS
>tr|F7D2J8|F7D2J8_HORSE Uncharacterized protein OS=Equus caballus GN=EPAS1 PE=4 SV=1
--------------------------------------------------------MRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIA
VVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVK
VYNNCP-PHNLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHL-AMNGIFDNSGE-VA-AKSNFLFTKLKEEPEEL
AQLAPTAGDAIISLDFAMQNFEESSAY---IL-----------------EARSLPAFTVPQAAAPG-STTPSA--------PSSPGDYY---NDDLKIEA
IEKLFAMDTEAKDQCSHT-DFNELDLETLAPYIPMDE-DFQLSPICPEERLLPENPQSIPQQCFSTMTNIFQPLAPVD-HRPFLLQQLES---KKIEPEH
----RPMSSFDGTKASLPLCCGQASTPLSSMGGRSNTQWPPDPPLTESLG---A------------SPLGP-PVT-SMFKKRS--FGP-RDPDTMSPAMI
ALSNKLKLKRQLEYE-QAFQDM-S--G-G---SHLMWKRMKSLRGGG-EAPQYQD---------------------------------------------
--------------YGL-PSGMASRLLGPSFEPYLLPELTRYDCEVNVPVPGSSTLLQGGDLLRALDQAS
>tr|F1M8I5|F1M8I5_RAT Endothelial PAS domain-containing protein 1 OS=Rattus norvegicus GN=Epas1 PE=4 SV=2
--------------------------------------------------------MRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIA
VVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLKTGSGFGKKNKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVR
VYNNCP-PHSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRILELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVVYNPRNLQPQCIMCVNYVLVGIEKNDVVFSMDQTESLFKPHL-AMNSIFDSSDD-VA-LKSNYLFTKLKEEPEDL
AQLAPTPGDAIISLDFG-QNFDESSTY---IL-----------------ESRSLPAFTVPQAGSPG-NATPSA--------PSSPEDYY---ENHLKIEV
IEKLFAMDTEAKDQCSQT-DFNELDLETLAPYIPMDE-DFQLSPICPEEPLVPESPQPNPQHCFSTMSSIFQPLTPGA-QGTFFLQQLES---RKTESEH
----WPMSTFDASKGSLPPCCGQASTPLSSMGGRSNTQWPPDPPLAEPLG---PLPLG-------TSQLEP-PST-SMFKMRS--FGA-RGPYMMSPAMI
ALSNKLKLKRQLDYE-PAFQDT-S--G-G---SHLMWKRMKSLMGG--EASPFQD---------------------------------------------
--------------YSP-PSGVASRLLGPSFEPYLLPELTRYDCEVNVPVPGSSTLLQGRDLLRALDQAT
>tr|H0VQK6|H0VQK6_CAVPO Uncharacterized protein (Fragment) OS=Cavia porcellus GN=EPAS1 PE=4 SV=1
--------------------------------------------------------MRLAISFLRTHKLLSSVCSENESEVEADQQMDNLYLKALEGFIA
VVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLKNGSGFGKKGKEISTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVK
VYNSCA-PHSLCSYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCINYVLSEIEKNDVVFSMDQTESLFKPHV-AMNSIFDNSDE-MA-AKSNFLFTKLKEEPEEL
AQLAPTPGDAIISLDFG-QNFKESSAF---IL-----------------EAGSLPAFTVPQVADPG-SSTPSA--------PSSPGDYY---GDDLKIEV
IEKLFAMDTEAKDQCSQT-DFNELDLETLAPYIPMDE-DFQL--------------QPTPQPCFSAMSSIFQPLAPVA-HSPFLLQQLEG---EKTEPDH
----RPMSSFDANKGSLPSCCGQASTPLSSMGGRSNTQWPPDPPLTESLG---T------------SPLGN-STA-SMFKMRS--CGP-RGADALGPWVA
L-AAPLPLHL------PF--FR-G--R-G---SHLIWETHEAPPGA--DAAPYQD---------------------------------------------
--------------YSL-PSGLASRLLGPSFEPYLLPELTRYDCEVNVPVPGSSTLLQGGDLLRALDQAT
>tr|I3IZ44|I3IZ44_ORENI Uncharacterized protein OS=Oreochromis niloticus GN=epas1 PE=4 SV=1
--------------------------------------------------------MRLAISFLRTRKLLAISCSSN-SDSEDNGQMDSLYLKSLEGFIT
VVTSDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHDEIRENLSLKTTSGFGKKGKELSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQLR
MYNSCP--RVLCGFKEPPLTCAVLMCEPIPHPSNIDTPLDSKTFLSRHSMDMKFTYCDERVTELMGYTPEDLLGRSIYDFYHALDSDSVTKSHQNLCTKG
QAVSGQYRMLAKNGGYVWVETQGTVIYNSRNSQPQCIVCINYVLSDIEEKSMILSLEQTESLFKPRH-SS--FFSP-GV-GM-SPGDALFTKFKEEPEDL
AQLAPTPGDTIISLDFSR-QFEEPQ-YSQVSASAMAP-----AP----VGKMAGGAFTVQQNP-P----------PGSA--PSSPDDYY---ESDLRVEL
TEKLFALDTEG-----ER-DLSDLDLETLAPYIPMDE-DFQLNPIVPESEPLEAAPAGSMGQSFNNVASLFQPLSTSSQ-GHYQRASSSWAGGEKRVSSQ
GNDPHGR-SMM-GHLHNPPYRAQASTPLSSMGGTQNLQWPPDPLLLEE-----------------RPSCKQNMPHG---------FV--QAYRDMSPARV
AMANSMKR--------S-FSQMAV----G---PEFIWKKIR---SDS-SSCDYRE---------------------------------------------
--------------YNMLPEGIASRLLGPSFEPSFLPELTRYDCEVNVPLQGNLHLLQGCDLLRALDQAT
>tr|Q6PI54|Q6PI54_XENLA Hif1a-prov protein OS=Xenopus laevis GN=hif1a PE=2 SV=1
--------------------------------------------------------MRLTISYLQIRKLLD-AGDL-DGETELDKQLNCFYLKALEGFVL
VLTEEGDMIYLSENVNKCMGLTQFELTGHSVFDFTHPCDHEELREMLTFRN--GPAKKGKEQITERSFFLRMKCTLTSRGRTVNIKSATWKVLHCTGHMR
VYDNAN-NQNHCGYKKPPMTCMVVICEPIPHPSNIEFPLDSKTFLSRHSLDMKFSYCDERVTELVGYEPDELLGRSVYEYYHALDSDHLTKAHHNMFTKG
QVTTGQYRMLAKKGGYVWVETQATVIYNSKNSQPQCIVCVNYVLSEVVEKDLILSLGQTASVLIPVEIKMPEIFTELNE--E-NNSECLFDKLKQEPESL
TVLAPDAGDEIIPLDFSSKPYEDVPLYNDVMLHSTSNKLESTRSNVDPNPEQLELAFTIPQLS-KP-DSPSDISSSQSST-PN-TPEYCFDVASEFKLDL
VEKLFAIDTEAKAPFTTQ-ET-DLDLEMLAPYIPMDD-DFQLRTFDQLSSLECDSSIPQ---TLGSMTTLFHQSLSPST--------------DFKPE--
DASDLKTII--QVHMMKEST-SAPVSPYNGNRSRTSSPVRPA------KA---VVDKT-------EKSRPGTPNLPVP-------KRCTILDEELNPKMI
AL-HNVQRKRKMESDGPLFQAIGI-TLDPGPNSSLQWKRVKGSDSERLSSAEQRT---------------------------------------------
--------------ILLLSTDMASQLLGQSFDGTVLPQLTGYDCEVNAPVHGTRNLLQGEELLRALDQAN
>tr|F7EH03|F7EH03_MACMU Uncharacterized protein (Fragment) OS=Macaca mulatta GN=EPAS1 PE=4 SV=1
--------------------------------------------------------MRLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIA
VVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGILNCVYFLLAPTGWESASPLSTSIREIA-HGLAMQEKWIVLHCTGQVK
VYNNCP-PHNLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESLFKPHL-AMNSIFDSSGK-GA-VKSNFLFTKLKEEPEEL
AQLAPTPGDAIISLDFG-QNFEESSAY---IL-----------------EAGSLPAFTVPQAAAPG-STTPSA--------PNSPEDYY---DNDLKIEV
IEKLFAMDTEAKDQCSQT-DFNELDLETLAPYIPMDE-DFQLSPICPEERLLAENPQSTPQHCFSAMTNIFQPLAPVA-HSPFLLQQLES---KKTEPEH
----RPMSSFDASKASLPPCCGQASTPLSSMGGRSNTQWPPDPPLTEFLG---A------------APLGP-PVS-STFKTRS--FGA-RGPDVLSPAMV
ALSNKLKLKRQLEYE-QAFQDL-S--G-G---SHLMWKRMKNLRGG--EATQYQD---------------------------------------------
--------------YSL-SSGMASRLLGPSFESYLLPELTRYDCEVNVPVLGSSTLLQGGDLLRALDQAT
>tr|W5P6T6|W5P6T6_SHEEP Uncharacterized protein (Fragment) OS=Ovis aries PE=4 SV=1
--------------------------------------------------------MRLAISFLRTHKLLSSVCSENESEADADQQMDNLYLKALEGFIA
VVTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHCTGQVK
VYSNCP-PPKFCNTHSPNAENLPLLC-PLQHQTHLRIPVQSSVFLERISLNLLFFFSQFRITELVGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKG
QVVSGQYRMLAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIEKNDVVFSMDQTESPFKPHL-TMNSIFDNSGK-VA-VKSNFLFTKLKEEPEEL
AQLAPTAGDTIISLDFG-PNFEESSAY---IL-----------------EAGSLPAFTVPQAAALG-NSTPSA--------PSSPGDYY---DDNLKIEA
IEKLFAMDTEAKDQCGQT-DFNELDLETLAPYIPMDE-DFQLSPICPEESLLPETPQSTPQHCFSTMSNIFQPLAPMA-HSTFLLQQLES---KKTEPEQ
----RRVSFFDGSKVSLLQRCGQTYTPLSSMGGISSTQWPPDPPLAEALG---T------------VPLGA-PIA-ATFKKRS--FGP-QGPDVMSPAMI
ALSNKLKLKRQLEYE-QAFQDL-S--G-G---SHLMWKRMKSLRGGG-EAPQYQD---------------------------------------------
--------------YSL-PSGMASRLLGPSFEPYLLPELTRYDCEVNVPVPGTSTLLQGGDLLRALDQAT
>tr|Q8QGM4|Q8QGM4_FUNHE Hypoxia-inducible factor 2 alpha OS=Fundulus heteroclitus PE=2 SV=1
--------------------------------------------------------MRLAISFLRTRKLIATSSGSGGCNGAEDELMDNMYLKSLEGFIT
VVTSDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKSAS-FRKKGKDVSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLK
MYDGCP--RVLCGYKEPPLTCAVLMCEPIQHPSNIEAPLDSRTFLSRHNMDMKFTYCDDKVTELIGYSPEDLMGRSIYEFYHALDSDSVTKSHHNLCTKG
QAVSGQYRMLAKNGGYVWVETQGTVIYNSRNSQPQCIVCINYVLSDVEEKSVIFSLEQTEALFKTPH-SR--FFTAEGA-GR-TPGDSLFTTFKEEPDEL
AQLAPTPGDTIISLDFGH-ELEKSQPFTPVSSASMHP-----AS----VP-NRAGAFTVQQNP-P----------PGSA--PSSPGDYY---ESDQRLEL
TEKLFALETEG-----EE-DLSDLDLETLAPYIPMDE-DFQLNPIIPESEPLEVAQTGSMGQSCNNVASLFQPLTSPRQ-NRYPPPQASWATGERRGSNP
ASDTRQR-SMM-GPTQSPHFRGPASTPLSSM------QWPPDPIIGEE-----------------RPSCQQNISYL---------FV--QAYKDVNPARV
AMNNSIKR--------S-FNQMAL----G---TDVVWKKMR---GDG-RSCSYTE---------------------------------------------
--------------YNPLPEGIASRLLGPTFEPSCLPELTRYDCEVNVPLQGSLHLLQGCDLLQALDQCI
>tr|A0A0B5L0B6|A0A0B5L0B6_SCHPR Hypoxia-inducible factor 2 alpha B OS=Schizothorax prenanti PE=2 SV=1
--------------------------------------------------------MRLAISYLRTRKLLTSACATATETTDVDRLMDSWYLKSLGGFIS
VVTSDGDMIFLSENINKLMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKAGMG--KKGKELSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLK
VYNGCP--RVLCGFKEPPLACVVLWCEPIAHPSNIDTPLDSKTFLSRHSMDMKFTYCDDRVTELMGYSPEDLLGRSAYEFYHALDSDNVTKSHQNLCTKG
QAVSGQYRMLAKNGGYVWVETQGTVIYNSRNSQPQCIVCVNYVLSDVEEKSMIFSMDQTESLFKAQH-NR--FFSPSKG-GL-GPGEVLFTKLKEEPEDL
TQLAPTPGDTIISLDFGN-QYEEHPMYSK---VSVVA-----YA----MA-KMATTFSVPQAPPA-----------SST--PSSPGDYF---DSDLKVEL
TEKLFSLDTQE-----ET-DLSDLDLETLAPYIPMDE-DFQLNPICQEEPSS-EIGALGTNQSFSNITSLFQPLSSPSV----ALPN-MSSGGDKQSING
GSESWPS-VSR-GPMQMPPYHDPASTPLSSMGGRQNLQWPPDPPLAKR-------------------SCQTVPAN-HPYLQRP--FV--QNYRDISPARL
ALANNFKR--------S-FTQMTM----P---QHTMWKRLR---NES-A-CNYRE---------------------------------------------
--------------FNMQPDGIASRLIGPSFKTYSLPELTRYDCEVNIPLQGNLHLLQGSDLLRALDQAT
>tr|B3DJD1|B3DJD1_DANRE Epas1 protein OS=Danio rerio GN=epas1b PE=2 SV=1
--------------------------------------------------------MRLAISFLRTRKLVNSGYNTPTEMTDADRLMDSWYLKSLGGFIT
VVTSDGDMIFLSENINKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKAGIG--KKGKELSTERDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLK
VCNGCP--RVLCGFKEPPLTCVVMMCEPIVHPSNIDTPLDSKTFLSRHSMDMKYTYCDERVTELMGYNPEDLLGRSAYEFYHALDAENVTKSHQNLCTKG
QAVSGQYRMLAKNGGYVWVETRGTVIYNSRNSQPQCIVCVNYVLSDVEEKSLIFSMDQTESLFKPHK-NG--FFSPK-E-AL-GPADLLFTKLKEEPEDL
TQLAPTPGDTIISLDFGQ-QYEEHTVYNK---VSSVA-----YS----MA-KMAATFSVPQSAPP-----------SSA--PSSPDDYY---DSDLKVEL
TEKLFSLDTQE-----ET-DLSDLDLETLAPYIPMDE-DFQLNPICPEEPPS-EIGTLGTNQCFSNITSLFQPLSSPSA----AHPK-MSSGGDKQNING
GSESWPP-VSR-DPMQMPPYHDPASTPLSSMGGRQNLQWPPDPPLAKR-------------------SCQGMPAN-APFMQRP--FV--QNYRDTSPARL
ALANSFKR--------S-FSQMAM----P---QQTVWKKLR---HES-N-CNYRE---------------------------------------------
--------------FNMQPDGIASRLIGPSFETYSLPELTRYDCEVNVPLQGNLHLLQGSDLLRALDQAT
>tr|A0A0B5KPE5|A0A0B5KPE5_HYPMO Hypoxia-inducible factor 2 alpha A OS=Hypophthalmichthys molitrix PE=2 SV=1
--------------------------------------------------------MRLAISFLRTRKLFNSGRTVQQTRYQDDSQMDSLYLKSLEGFVA
VVTSDGDMIFLSENVSKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSVKSGPVYGRRGKDMSTGRDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLQ
VCSSRP--QVLCGFSDPPLTCVTMLCAPIPHPSNVDTPLDSKTFMSRHSMDMKFIYCDERVSSLIGYRPEELLGRSVYEFCHALDSESMTKSHQNLCNKG
QVVSGQYRMLAKHGGYVWVETQATVIYNNRNSQPQCIICINYVLSSVEEQSLIFSLDQTEALFKPYHMGE--LFSQGGA-SS-VAQDNLFTKLKEEPEEL
AQLAPMPGDAIIALDFER-EFEEPTYFSK---STKL------PD----LS-SMPSTFSVPQAPPVG---------PCTTPCPSSPVDYC---ECDLKVEL
TEKLFTPESV------QL-DLSNLDLETLAPYIPMDE-DFQLHPICLEEPVPDTSPGLSTAHSFSSVADLFQPLSPFPP-K--------------SSPNT
---------CP-DTAHVQPYQTATNVPHSSEEGRQNLQWTPDPPSTAD-----------------P--RQ-TCSF-ALPQQRF--FAP--VQKDMSVRQI
ALLNNFKRKRPSEFSLS-FSDIPK----P---ADGMQKRMKTMNVDS-SSPSNRQ---------------------------------------------
--------------YHMMPSGMISQLLGPSFDSYCLPELTRYDCEVNVPLQGTLHLLQGSDLLRALDQSK
>tr|E7FAJ1|E7FAJ1_DANRE Uncharacterized protein OS=Danio rerio GN=epas1a PE=4 SV=1
--------------------------------------------------------MRLAISFLRTRKLFSSGHTVQQMRSQNLGQMDNLYLKSLEGFVI
VVTSDGDMIFLSENVSKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSIKSGPVYGRKGKEMSTSRDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGHLQ
VCSSRP--QILCGFSEPPLTCITMLCAPIPHPSNVDTPLDSKTFMSRHSMDMKFIYCDERVSSLIGYRPEELLGRSVYEFCHALDSENMTKSHQNLCNKG
QVVSGQYRMLAKNGGYVWVETQATVIYNNRNSQPQCIICINYILSSVEEQSVIFSLDQTEALFKPYHMGE--IFSQNT---S-IPQNNLFTTLKEEPEEL
AQLAPMPGDAIIALDFER-EFEEATFFSK---SSKLP-----PE----LS-SLPSSFTVPQVPPAG---------PCTTPCPNSPVDCC---EWDLKVEL
TEKLFAPESG------QL-NLSDLDLETLAPYIPMDE-DFQLHPICLEEPVPDAGPGLSAAHSFSSVADLFQPLGQYPP-K--------------NRPST
---------CP-DSTHIQPYQTTPNIPLSSEKQRQSLHWPPDQLSTGG-----------------P--GQ-TCNF-PPPHQRF--FTP--VQKGMSLGQR
ALLNNFKRKRQSEFPLS-FSDIPK----A---TDGMRKRMKPMNDDS-PSNSSRQ---------------------------------------------
--------------YNMMPTGMISQLLAPSFDSYCLPELTRYDCEVNMPLQGNLHLLQGSDLLRALDQST
>tr|A0A0B5L0B1|A0A0B5L0B1_9TELE Hypoxia-inducible factor 2 alpha A OS=Gymnodiptychus pachycheilus PE=2 SV=1
--------------------------------------------------------MRLAISFLRSRKLFNSGRTVLQTQSQDDSQMDSLLMKSLEGFVA
VVTSDGDMIFLSENVSKFMGLTQVEMTGHSIFDFTHPCDHEEIRENLSVKSGTLYGRRGRDMSTGRDFFMRMKCTVTNRGRTVNLKSASWKVLHCTGQLQ
VCSSRP--QVLCGFSEPPLTCVTMLCAPIPHPSNVDTPLDSKTFMSRHSMDMKFIYCDERVSSLIGYSPEELLGRSVYEFCHALDSESMTKSHQNLCNKG
QVVSGQYRMLAKHGGYVWMETQATVIYNNRNSQPQCIICINYILSSVEEQSVIFSLDQTESLFKPYHMGE--LFSQGGA-SS-VAEDILFTKLKEEPEEL
AQLAPMPGDAIIALDFDR-DFEEPTFFSK---STKLP-----PD----LP-NMPSTFTRPQVPSAG---------PCSTPCPSSPVDYC---ECDLKVEL
TAKLFASESV------RL-DLSDLDLETLAPYIPMDE-DFQLHPVCLEEPVSDTGPGLNKAHSFSSVADLLQPLGPFPP-K--------------SSTNT
---------CP-DTAHVQPYQTTPNVPFSSREGRQILQWPPGPPSTAD-----------------P--GQ-ACNF-ALPQHRF--FAP--VQKLMTVGQI
ALVNNFKRKRSSEFSSS-FTDIPK----A---ADGMQKRMKTMNVDS-SSPSNRQ---------------------------------------------
--------------YHMMPTGMISQLLGPSFDSYCLPELTRYDCEVNVPLQGNLHLLQGSDLLRALDQTT
>tr|S4RYA8|S4RYA8_PETMA Uncharacterized protein (Fragment) OS=Petromyzon marinus PE=4 SV=1
--------------------------------------------------------MRFAISFLRMRKLLASDGST--EHIDSMGDIDPAFLKVLEGFFL
VMNHDGDIVYLSDNVSKYLGTTHVDLVGQSIFDFTHPCDHEEIKEILSCKQVLGSAKKNKETPTEIDFLMRMKCTITNRGRTVNLKSASWKVLNCSGHQK
VCGSSS-SESSHGFKDPAQTYLVLICQPIPHPAELEAPLDSHTFLSRHTLDMKFSYCDDRVVDLIGYCPEELLGKSVYEYYHALDSDNITKSHHSLFSKG
QAKTGQYRMLAKHGGYVWVQTQASVIYNSRSAQPQSVVCIHYVLSGVEENTTIFSLEQTERLFKLQDGAEGDEACP-RE-AP-QDSGRLYAMLKEEPDEL
AQLAPTPGDTIVPLQFNS-VFIYTYNYNS---APL-------AP----SGDTQVSPFTAHQMSTR-----------TSTPSPGSPEDVY---CNDLRVEL
VEKLFAKSTDI-----QD-DYSTVDLEMVAPYIPMDE-DFQLCSLSLQEQMATPSPLQLSNHCCRQGSSIKLQIPSHSQ-Q-AASLPDAWASQGI-----
--VTKPA-I-----YNDSSFYGATDQGL-AAAGKCGSSWPYKSNSGEK-G---FKR-------------DASVAA-QMYQRNR--FGPCKRS--------
PELSNLKRKWHLDGGIK-NPYTHM----A---SHPPWKRSKVWDDTS-KACPPLQ---------------------------------------------
--------------QQYLSTGLASCLLGRSFEGVHLPTLTSYECEVNAPVQDIQNLLQGKDLLMALDQAT