>seq_1
PVLQVYLYHSLGKSEADYLTFPSGEYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYFPRWYCSGSNRAYRHGI
SRGAEAPLXXKFEVKEPGSGPSGEEIFATIIITGNGGIQWSRGKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSNESRVVTIHKQDGKNLEIELSS
LREALSFVSLIDGYYRLTADAHHYLCKEVAPPAVLENIQSNCHGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNE
NEEYNLSGTKKNFSSLKDLLNCYQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKIRNEDLIFNESLGQGTFTK
IFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLA
WAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALD
SQRKLQFYEDRHQLPAPKWAELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKG
NFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTS
QICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPP
AEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
>sp|Q75R65|JAK2_CHICK Tyrosine-protein kinase JAK2 OS=Gallus gallus GN=JAK2 PE=2 SV=1
PLLQVYLYYSPGKTGGDYLQFPAGEYVAEEICIVACKACGIMPVYHNMFALMSETERVWYPPNHIFHVDEATRLKLLYRIRFYFPHWYCNGTSRACRYGI
IRGSESPVLEVFEVKEPGGDPSGEESFATIVITGNGGIQCSRGKLKNCETLAEQDLQTYCDFPDIIDVSIKQASQEGSSERRIVTIHKQDSKNLEAEFQS
LREALSFVSLIDGYYRLTADAHHYLCKEVAPPSVLENIQSNCHGPIFMDFAINKLKKAGNQTGFYVLRCSPKDFKKYFLTFAIERENATDYKHCLITKNE
NGEYNLSGTKRSFGNLKDLLTCYQTETVRSDSIIFQFIKCCPPKPKDKSNLLVFRSNSVSDVPSSPTLQRH-NVSQMVFHKIRNEDLIFEESLGQGTFTK
IFKGIRKEVGDYGQLHQTEVLLKVLDKVHRNYSESFFEAASMMSQLSYKHLVLNYGVCVCGEENILVQEYVKFGSLDTYLKKNKNVINILWKLEVAKQLA
LAMHFLEDKGLVHGNVCAKNILLIREEDRKSGNLPFIKLSDPGISITVLPRDILLERIPWVPPECIENPRQLSLATDKWSFGTTLWEICSGGDKPLSALD
SSRKLQFYEDRHQLPAPNWTELANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNIRTGALGFSGAFEDRDPTQFEERHLKFLQQLGKG
NFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERLDHKKLLLYAS
QICKGMEYLGTKRYVHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPP
AEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYAIMKECWNNNVAQRPTFRDLAQRVDQIRDNMGG
>sp|P52333|JAK3_HUMAN Tyrosine-protein kinase JAK3 OS=Homo sapiens GN=JAK3 PE=1 SV=2
AGALHVLLPARGPGPPQRLSFSFGDHLAEDLCVQAAKASGILPVYHSLFALATEDLSCWFPPSHIFSVEDASTQVLLYRIRFYFPNWFGL--EKCHRFGL
RKDLASAILETFHVGLPGAL-GGHDGLGLLRVAGDGGIAWTQGEQ--------EVLQPFCDFPEIVDISIKQAPRVGPGEHRLVTVTRTDNQILEAEFPG
LPEALSFVALVDGYFRLTTDSQHFFCKEVAPPRLLEEVAEQCHGPITLDFAINKLKTGGSRPGSYVLRRSPQDFDSFLLTVCVQNPLGPDYKGCLIRRSP
TGTFLLVGLSRPHSSLRELLATCWDGGLHVDGVAVTLTSCCIPRPKEKSNLIVVQRGHSPPTSSLVQPQSQYQLSQMTFHKIPADSLEWHENLGHGSFTK
IYRGCRHEVVD-GEARKTEVLLKVMDAKHKNCMESFLEAASLMSQVSYRHLVLLHGVCMAGDS-TMVQEFVHLGAIDMYLRKRGHLVPASWKLQVVKQLA
YALNYLEDKGLPHGNVSARKVLLAREG--ADGSPPFIKLSDPGVSPAVLSLEMLTDRIPWVAPECLREAQTLSLEADKWGFGATVWEVFSGVTMPISALD
PAKKLQFYEDRQQLPAPKWTELALLIQQCMAYEPVQRPSFRAVIRDLNSLISSDYELLSDPTGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKG
NFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSS
QICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPS
AEFLRMMGCERDVPAL-CRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRG
>sp|Q63272|JAK3_RAT Tyrosine-protein kinase JAK3 OS=Rattus norvegicus GN=Jak3 PE=2 SV=1
AGALHVLLPPRGPGPPQRLSFSFGDYLAEDLCVRAAKACGILPVYHSLFALATEDLSCWFPPSHIFSIEDVDTQVLVYRLRFYFPGWFGL--ETCHRFGL
HKDLTSAILESFLVGLPGAQ----EEPGCLRVTGDNGIAWSSKDQ--------ELFQTFCDFPEIVDVSIKQAPRVGPGEHRLVTITRMDGHILEAEFPG
LPEALSFVALVDGYFRLICDSRHFFCKEVAPPRLLEEEAELCHGPITLDFAIHKLKAAGSLPGSYILRRSPQDYDSFLLTACVQTPLGPDYKGCLIRQDP
SGAFSLVGLSQLHRSLQELLTACWHSGLQVDGTALNLTSCCVPRPKEKSNLIVVRRGRNPTPAPGHSP-SCCALTKLSFHTIPADSLEWHENLGHGSFTK
IFHGHRREVVD-GETHDTEVLLKVMDSRHQNCMESFLEAASLMSQVSYPHLVLLHGVCMAGDS-IMVQEFVYLGAIDTYLRKRGHLVPASWKLQVTKQLA
YALNYLEDKGLPHGNVSARKVLLAREG--VDGNPPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEAGTLNLEADKWGFGATTWEVFSGAPMHITSLE
PAKKLKFYEDRGQLPALKWTELEGLIAQCMAYDPGRRPSFRAILRDLNGLITSDYELLSDPTGIPNPRDELCGGAQLYACQDPAIFEERHLKYISLLGKG
NFGSVELCRYDPLGDNTGPLVAVKQLQHSGPEQQRDFQREIQILKALHCDFIVKYRGVSYGPGRQELRLVMEYLPSGCLRDFLQRHRARLHNDRLLLFAW
QICKGMEYLGARRCVHRDLAARNILVESEAHVKIADFGLAKLLPLGKDYYVVRVPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYSDKSCSPS
TEFLRMIGPEREGSPL-CHLLELLAEGRRLPPPSTCPTEVQELMQLCWSPNPQDRPAFDTLSPQLDALWRGSPG
>sp|P23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 OS=Homo sapiens GN=JAK1 PE=1 SV=2
PGVEVIFYLSDR----EPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEVWRHSP
KKQDATPLLEIFETSMLLISSDGNVLYYEVMVTGNLGIQWRHKPNVVSKNKIREEWNNFSYFPEITHIVIKE---------SVVSINKQDNKKMELKLSS
HEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKAQKQFKNFQIEVQ-
KGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQ-------EWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTH
IYSGTLMDYKDDSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLA
SALSYLEDKDLVHGNVCTKNLLLAREGID-SECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKT
LIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSE-K-------------KPATEVDPTHFEKRFLKRIRDLGEG
HFGKVELCRYDPEGDNTGEQVAVKSLKPSGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV
QICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPM
ALFLKMIGPT-HGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK----
>sp|O12990|JAK1_DANRE Tyrosine-protein kinase JAK1 OS=Danio rerio GN=jak1 PE=1 SV=1
KGLEIHFYLADT----HQLEFFKACYTAEDLCVEAAKRCRISPLCHNLFALYEESQDLWYAPNHVFKVTDETSIKLHYRMRFYFTNWHGTSEIEVWRHTL
SKQEGTPLLEIFKPKNLKVTGLGNGMGYEVQVYGTTGISWRRKPAPNQ-KKKDSGWTLFSDFHEITHIVIKD---------CCVTIYRQDNKTMELDLFY
RDAALSFAALVDGYFRLTVDAHHYLCTDVAPSSVVQNLENGCHGPICTEYAIHKLRQEGNEEGTYVLRWSCTEYNFIIMTVVCIELPVPQYKNFQIETS-
PQGYRLYGTDTFRPTLKELLEHLQGQLLRTDNLRFQLRRCCPPQPREISNLLVMTTDREP------VPQKKTQVSQLSFDRILKEEIVQGEHLGRGTRTN
IYAGILKPKSDDGYSQEVKVVLKVLGSGHRDISLAFFETASMMRQISHKHTALLYGVCVRHQENIMVEEFVQYGPLDLFMRRQTTPLSTAWKFQVAKQLA
SALSYLEDKKMVHGYVCSKNILVARDGLD-GEGGPFIKLSDPGIPITVLSREECVDRIPWIAPECVKDTANLTIAADKWSFGTTLWEICYNGEIPLKDKK
LSEKERFYAAQCQLATPDCDELAKLMTHCMTYDPRQRLFFRAIVRDIVMVEKQNPSIQ---P-------------VPMLEVDPTVFEKRFLKKIRDLGEG
HFGKVELCRYDPRGDRTGELVAVKSLKPNREEQSNNLWREIHILRELYHENIVKYKGICNEEGGRSIKLIMEFLPAGSLKEYLPRNKAHINLKTLHNYSV
QICQGMDYLGSRNYIHRDLAARNVLVENEGTVKIGDFGLTKSIKDNEGYYTVKDDLDSPVFWYAPECLIHCKFYRASDVWSFGVTMYELLTYCDASCSPM
SVFLKLIGPT-HGQMTVTRLVKVLEEGKRLPRPDDCSEQLYNLMRRCWEATPEKRIDFKSLIANFQQMLDNL--
>sp|Q09178|JAK1_CYPCA Tyrosine-protein kinase JAK1 OS=Cyprinus carpio GN=jak1 PE=2 SV=1
KGLEIHFYLPDT----HQLEYFKDCHTAEDLCVEGCQEDATSHLCDNLFALSEESQDLWYAPNHAFKITEETSIKLHYRMRFYFTNWHAPVRTEVWRHSL
FKHEGTPLLETIEPKILKVSGSGDGLGYEVQVSGTTGISWRRKPVPNIMTKRKTVMTIFSDFFEITHIVIKE---------SCATIYSQDNKTMELDLFY
RDAALSFAALVDGYFRLTVDAHHYLCTEVAPSSVVQNLENGCHGPICTEYAIHKLRQEGNEEGTYVLRWSCTDYNYIIMTVVCIEMPVPQYKNFQIETS-
PQGYRLYGTDTFRPTLKELLEHLQGQNLRTENLRFQPVLVGLGQPRKISNLLVMTRDREP------DSQRQPQVSQLSFHRILKEEIVQGEHLGRGTRTN
IYSGVLKLKSEDGYSQEVKVILKVLGSGHRDISLAFFETASMMRQISHKHIALLYGVCVRHQENIMVEEFVQYGPLDLFMRRQSIPLSTAWKFQVAKQLA
GALSYLEDKKLVHGNVCSKNILVARDGLD-GEGGPFIKLSDPGIPITVLSREECVDRLPWIAPECVQDTANLSIAADKWGFGTTLWEICYNGEIPLKDKK
LTEKERFYAAQCQLASPDCEELAKLMTHCMTYDPRQRLFFRAIVRDIDMVEKQNPSIQ---P-------------VPMLEVDPTVFEKRFLKKIRDLGEG
HFGKVELCRYDPRGDRTGELVAVKSLKPNREEQSSNLWREIHILRELYHENIVKYKGIWHEEGGRSIKLIMEFLPAGSLKEYLPRNKAHIDLKTLLNYAV
QICQGMDLLASRNYIHRDLAARNVLVENENTVKIGDFGLTKSIKDNEGYYTVKDDLDSPVFWYAPECLIHCKFYRASDVWSFGVTMYELLTYCDISCSPM
SVFLTMIGPT-HGQMTVTRLVKVLEEGKRLPKPDGCSDRLYCLMRRCWEATPEKRIDFKGLIANFQQMIDNQ--
>sp|Q9R117|TYK2_MOUSE Non-receptor tyrosine-protein kinase TYK2 OS=Mus musculus GN=Tyk2 PE=1 SV=2
GCLMVLLHWPGPEGGEPWVTFSQTSLTAEEVCIHIAHKVGITPPCLNLFALYNAQAKVWLPPNHILDTSQD--MNLYFRMRFYFRNWHGMNPQEVYRCGF
PGAQGVQLLERIPVCHLEVLASGGPPTHEVLVTGTGGIQWHPLQTQESESPQEPPWTYFCDFQDISHVVLKE---------RRVHIHLQDNKCLLLCLCS
QAEALSFVALVDGYFRLTADSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQAKLWP---EDGLYLIQWSTSHLHRLILTVAHRNPRGLRLRKFPITQQ-
PGAFVLDGWGRSFASLGDLRLALQGCSLRAGDDCFPLHXCCLPRPREISNLVIMRGSRA--------HTRPLNLSQLSFHRVHQDEITQLSHLGQGTRTN
VYEGLLRVG---TSGQQLRVVLKVLDPSHHDIALAFYEXASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLA
SALSYLEDKNLVHGNVCGRNILLARLGLE-EGTNPFIKLSDPGVGQGALSREERVERIPWTAPECLSGGSSLGTATDMWGFGATLLEICFDGEAPLQGRG
PSEKERFYTKKHQLPEPSCPELATLTRQCLTYEPAQRPSFRTILRDLTRLQPQNLVGTSAVN-------------SDSPASDPTVFHKRYLKKIRDLGEG
HFGKVSLYCYDPTNDGTGEMVAVKALKECGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC--VGLAQLLLFAQ
QICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPH
TKFTELIGHT-QGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQTAQEKYQG
>sp|P29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 OS=Homo sapiens GN=TYK2 PE=1 SV=3
GGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREVYRCGP
PGTQGMQLLERVPVCHLRLLASGGPPTHEVLVTGTGGIQWWPVEEEVNDRPREPLWAYFCDFRDITHVVLKE---------HCVSIHRQDNKCLELSLPS
RAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRP---EDGLYLIHWSTSHPYRLILTVAQRSQQSLRLRKFPIEQQ-
DGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARA--------SPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTN
VYEGRLRVEGSGDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLA
SALSYLENKNLVHGNVCGRNILLARLGLA-EGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGNSLSTAMDKWGFGATLLEICFDGEAPLQSRS
PSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVN-------------PDSPASDPTVFHKRYLKKIRDLGEG
HFGKVSLYCYDPTNDGTGEMVAVKALKACGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS--IGLAQLLLFAQ
QICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPP
TKFLELIGIA-QGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQG
>tr|M7AKN2|M7AKN2_CHEMY Tyrosine-protein kinase OS=Chelonia mydas GN=UY3_17936 PE=3 SV=1
GGLKVYLHWN-GEEEERCQTYTQGVLSAEEICINIAQKIGITPLCYSLFALCDVQTRVWLPPNHVFEISKDTNLNLFFRMRYYFRNWHGMSDKAVYRNVP
RQSDNMALKTSFKGCIPGSENGGRPATHEVLVTGTDGIQWRTVPVCQPVERSEAKWVRFCDFQEITHIVLKDC---------KVSINRQDNKCLELVLPS
HETALSLVSLVDGYFRLTADSSHYLCHEVAPPRLVMSVLNGIHGPMQEEFVFAKLKRE-EQDGLYVIRWSVLNFNRLILSVV-KRDTTPTYRQFRI-QKR
GVSFVLEGWEREFSTVRELMDVLKGCTLKSGEESFAVRRCCPPKPGEISDLIIARKVKDS-------TRQILNLTQLSFHQIRKNEITQRAHLGQGTRTN
IYEGVLHVCGGANNSREMHVVLKVLDPSHRDIALAFFETASLMSQVSHIHLAFVHGVCVRGSENIMVEEYVEHGPLDVLLRKEKGRVTVGWKVTVAKQLA
SALSYLEDKNLVHGNVCAKNILLARKG-LEDGLLPFVKLSDPGVSFTVLSREERVDRIPWIAPECVQDVSSLSTAADKWSFGTTLLEICFDADVPLKERT
PSEKERFYEKKHRLPEPSCKELAALISQCLTYAPSERPSFRTILRDLTQLQPHNLVVTSVS---PDF-----------PVSDPTVFQKRYLKKIRELGEG
HFGKVSLYCYDPTNDGTGEMVAVKSLKSGSQQLLTSWKREIEILKTLYHENIVKYKGCCSEQGEKIVQLIMEYVPLGSLRDYLPKHN--VSLAHILLFAQ
QICEGMAYLHSLHYIHRDLAARNVLLENENVVKIGDFGLAKAIPEGHEYYRVCEDGDSPVFWYAMECLKECKFYYASDVWSFGVTLYELLTRCDSSQSPP
VKFIEMIG-VTQGQMTVLRLIELLDRGKRLPSPKDCPCEIYCLMRNCWESKASFRPAFKNLVPILKSFHEKYK-