>seq_1
MPTVAVPERDDTRALTVVMHTAFFVLLSASVARYLARHADGPHTPWVIALSVLLAALYVLGSALGTRPTPRRLTWLGLVVAAWALLVVLAPSFAWCAVPL
FYTGLRTLPLRAAVPLVALLTALAVAAQLRLAGWADPNVLLAPPAVAAVATTVFVVMQRQAVRRDALIDDLVRTRRELAATERREGTLAERERLAREIHD
TLAQGLSSQRMLLQAADRLWDTAPGTARDHVRTAAAIAERSLAEARRFVHDLTPADLAEGGGLLQALRAVAERETTPRLTVRVHTEGSPPDPLPAPVESA
LLRIAQGALANVREHAAATTATLTLTCLDDQIVLDVTDDGRGFDPGAPAPAPAAATDSRGHGLPAIRARLRQLGGTLTIESAPGEGTALSAAIPLEPR
>tr|C7NKJ3|C7NKJ3_KYTSD Signal transduction histidine kinase OX=478801 OS=(Micrococcus sedentarius). GN= PE=4 SV=1
-----------DRLARLLAGALLLSLLALATWRSGAQAGDGPDLPWWLAFAGLLTP--RLRNSTPRRPYTGAAVWLVALSVGWAALMTTHEAFAWVAFPL
FLLWLMHLPLVAAVPAVLALTAVVGVVELAQEDWGG---VLGPALAAALGAWTMTRLRQESEARARLVAELRSTRQELAAAHTEAGALAERHRIARDLHD
TVVQSFTSVLLLARAG--------GRPEEVLPRIEEVAADGLAESRRVVQTLRRE---PGRTLADALRRAAAGVVDPPTSFTL--TGTPRE-LPTATEVG
LLRIAQGALGNVTEHAGASQAWVELAFTPDAVRLEVRDDGRGVAPVAPGAAPGAAPGARGTGLAGARDRAEDLGGSFALRSPAGRGTHVVVEVPA---
>tr|Q9KXW6|Q9KXW6_STRCO Putative histidine autokinase OX=100226 OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). GN= PE=4 SV=1
-------ADADRRWLGAVMHVAFFLLLGGALARFLLRHPGEPRTPWILALSLTLAVLHLLGPVLSGPGPSRRLVRLGLVVVVWMVLVVLAPSFSWCAVPL
FYTGLRTLPTRAALVLVTVLTVLVVAAQFRLAGGFDPNLLLAPPAVAAIAAAVFLHTERQAARQRALIDDLIRTRRELAASERREGTLAERQRLSMEIHD
SLAQGLSSQRMLLQAAERVWESDQDKARAHVRGAASVAEHNLAEARRFVHDLAPADLARGGGLEAALRALAARESGDHLTVRVHVDDGTRVPLPDRVQSA
LLRIAQGALANVREHAGASTAALSLTLLDDEVVLDVTDDGHGFDPAGPSDAPAG---TRGHGLPAMHARLRQLGGTLTVESAPGEGTALSAAIPLDPQ
>tr|F3ZE01|F3ZE01_9ACTO Putative histidine autokinase OX=355249 OS=Streptomyces sp. Tu6071. GN=STTU_3703 PE=4 SV=1
-------AEADERRLTALLTVAFLALLAGALLRYVLRHGDSGRLSWVVALSVVLAGTQL----VRGGSARARRGRLGVVAVCWAVVVLLAPSFAWCAIPL
VHTALRVLPVRAALAAITALTALVVLAELRLADGFDPNLVLLPPVVAALATGVFLHLSRESARRGALIDDLVRTRRELAATERREGTLAERQRLSGEIHD
TLAQGLSSQRMLLQAAERQWDRDPEAARAHVRTAAGIAAEGLAEARRLVHDLGPAGLAGGTDLGAALTALAARSSHDGLAVRVHDEAGPAV-LPDRVASA
LLRTAQGALANVREHARARTATLTLTLLDDLAFLDVADDGRGFVPDLAA-RARG---PRGHGLPATRARLQQLGGTLAVESAPGEGTVLTARVPLHPT
>tr|G0CQA4|G0CQA4_CORUL Two-component system sensor kinase protein OX=945711 OS=Corynebacterium ulcerans 809. GN= PE=4 SV=1
-------MKPHVTLLRVSLHLMFAALLGFGIIRFALN-PESDS-PWKIALALVLGAFYMFGTARFARGDNLSGWWMLAITLIWALLMGASGSFTWLMFPL
MFIALNLLPIRGVLGVLTLLGIATVIPWIARPEDWTLGQLFGPIIGACFSVAVYYVLNQDAMHYRQVAAELLAAQRDLAASEHQSGRLEERERLSREIHD
TVAQGLSSIVLLSRAAHGHLERGELEVHQQLTVIEKQAGESLAEARRFVRDLAAPSL--GDSLSTALRGVEKQAALGCIDAHLELVGDAETSLPEPVTRT
ALRVAQEGLNNVVKHAQASKAVVTLGIWEDEVSIDVVDNGLGFDLDASGEQTE-----GGFGLEGLKKRISTVGGTLVIESDE-YGTALACRIPLTSR
>tr|K1VP44|K1VP44_9ACTO Signal transduction histidine kinase OX=1195457 OS=Streptomyces sp. SM8. GN= PE=4 SV=1
-------QTRDDRWLSALLTTAFVVLLAGALLRYVLKHGDSDRLPWIVGLSVVLAVVQVAGQ-ARPGSRRAGRVRLAVVVACWVVVVLLAPSFAWCAVPL
IHTALRLLPTRSAVALVTALATLVVLAELRLADGFDPNHLLLPPVVAALATGVFVYLTREATRRQHLIDDLVRTRRELAATERREGTLAERQRLSREIHD
SLAQGLSSQNMLLQAADRQWDTDPQAARTHLRTAASIAAHGLTEARRLVHDLAPADLAEGAGLAQALATLAARESRDGLTVRFHAE-GPDTHLPDQVASA
LLRTAQGALANIREHSGARTAALTLTCLDDTVALDVADDGRGFPAPGPG-GARDPLPLRGHGLPAIRARLRQLGGTLAIESTPGEGAVLTATIPLTPA
>tr|E4WBI6|E4WBI6_RHOE1 Two component system sensor kinase OX=685727 OS=Rhodococcus equi (strain 103S) (Corynebacterium equi). GN= PE=4 SV=1
-------ENADNGPLGVAIHLSFYVLLAASTARYLTYHGVSGR-WLVVALIVVLAGLYAVIVVLS----RAWQPWVWPVLTSWVALVWLAPSFAWTAFPI
FFLCTRAFPRWAAYLIVAALAVFAGIEFASFSGRTEWAVLLAPLCTGALIVLAYGQVERDSAERERLLGELVDAKSRLAETEREAGVLSERERLAREIHD
TVTQGLTSALLHLEAADEVWERSGPRARDEVRVATRSLRENLAETRNLVHYLSSPDLT-TQTLDAALLAAVRGYVPSALRVI----GEPVG-LPPDVEHA
LLRIVQSAASNIRRHADAHTVGVTLTYLPDAVALDVFDDGSGF-------VVGE---TSGFGLPAMRQRVEALGGTFSVESAPGEGTVVAAQIPI---
>tr|D9VDL3|D9VDL3_9ACTO Histidine autokinase OX=591158 OS=Streptomyces sp. AA4. GN=SSMG_05748 PE=4 SV=1
-------TDRDGRWLAATMHTAFFLLLVASIVRFLDHHHGEPAAPWVIALTGCLAAVYAVGLVLRVTGPEPYLAWLTVVTVLWVVLVLLAPSFAWCAVPL
FVTGLRTLPTRPALVLVTLVTALVVISQNRLSTGFDPNLTIVPVAVAAVTAAVITYLRRQAVR--------------LRETERRAGMLDERQRLSREIHD
ALAQGLSSQAMLLQAADRAWD-NPDLAREHLHAAQQIGTRNLAEARGLVQDLAPADLD-GHSVEEALRNVAEREPQP---VRVQVD-GPARPLPSRVQST
LVRIAQGALANAREHADASGVALTLTYLDDEVVLDITDDGRGFDPAAPS-TDG-----RGHGLPAMRARATQLGGRLTVESAPGQGTAISVAIPLG--
>tr|C9ZEX3|C9ZEX3_STRSW Putative histidine autokinase OX=680198 OS=Streptomyces scabies (strain 87.22) (Streptomyces scabiei). GN= PE=4 SV=1
-------TDPDGRWLAAVVHAAFFLLLCSSFARFLTRDQGGARTGWVIALFAVFGLLYALGQLLAPAPPPRHLTWLGSVTAVWVVLLALAPSATWCAMPL
LFAGFHTLPPRMAVPLAVLVTTLVVAAEIRVSEGINPNMVAAPPAVAAVATAVFVHLRRQAARQRVLIGDLVRTRRDLAATERRAGVLAERQRLATEIHD
TLAQGLSSQRMLLQAAERVWATDPDAARAHIARAAEITSHSLAEARRFVHDLAPADLV-ERSLPAALGALAERESGPGLTVEFRLDGRLGT-LPERAEAA
LLRIAQGALANVREHAAATRAALTLTCLDDQVSLDIADNGRGFDEAGRAGAAGR---ERGHGLPAMRVRARQSGGTLTVESTPGEGTVVSAALP--AG
>tr|H2HZ51|H2HZ51_CORDW Heme-responsive histidine kinase OX=698964 OS=Corynebacterium diphtheriae (strain PW8). GN= PE=4 SV=1
-------VKPHVTVMRVSLHVMFAALLLFGIARYLIDRPASPN-SWFLAIAVILGVFYMIGTARFARGDDLSPLWLIVVVALWALLVSTSSYFLWLMFPL
IFVMLHLKHIHGILGVASLLVIAIAIPLVTRPADWGPAHAMGPAIGAAFSIVIFATLRNDAQHYRQLAAELLAAQQDLATSEHQAGRLEERERLSREIHD
TVAQGLSSIVILARAAHGRLDKGEIEVAQQLSVIETQASDSLAEARRFVRDLAAPAL--GDSLPIALTSTTKQDALGALDVHLELVGDTSISLPEPVSRT
VVRVTQEGLNNVVKHAHATKAVVTLGVWEDEVSLDVVDNGIGFNLGTTERGTS-----SGFGLDGLRKRVDTVGGTLVIESDT-YGTALACRIPLTSR
>tr|D8I5Z7|D8I5Z7_AMYMU Two-component system histidine kinase OX=749927 OS=Amycolatopsis mediterranei (strain U-32). GN= PE=4 SV=1
-------PPRNRRFVLSGAHLAFFALVGVALIRLDTAYGA---LCWIVTISGLLAVVYVLGQTRGGLSTPWGLAWVAALVVLWALIIVLAPAYVWCAVPL
AYAGLHVLDHRAGPVAVAVITVVLVGRQVAAAGPFALEAAVVPVVAVWATLALHRAQQRNAAERQRLVDDLRSTRDVLAEEQRRAGMLEERARIARDLHD
SLAQELSGSVLMLQATERNWPDRTDAARARVREVVDRLQDELAETRRVIRDLAPSALS-ESGLDGALRLLCARAHQDGAQVRFQVAGTADCPLDEQTAAT
LFRVAQSVLANVREHARAVNVQVTLRRHPELVELEISDDGAGFDPAGRVSGTG-----RGLGLPAARTRLDRLGGALDVDSTPGRGTRVTAMVPTRVR
>tr|J7LR65|J7LR65_9MICC Putative signal transduction histidine kinase OX=1118963 OS=Arthrobacter sp. Rue61a. GN=ARUE_c04360 PE=4 SV=1
-------NQPSNGRLDAVVHSGFAVLMVASAVRYVMRHSPADN-LWTVALAIAVCALYAVTAVLAHRQPRLWIPWMVALVAAWAALVVVAPSFAWCSFAI
FFLTRTAFRGWSGYVAGGATAAATAVGLFRMSDWTDIAMLLGPLAAGALLTLIYDKIERDAALQRRLFDDVTLAQEQLAAKQREAGIATERERVSREIHD
TVTQGLASSLLLLEAAQRSWPAET--AHDDVRKATDLLRRNLADTRSLVHELSAPGLE-TGPLPEALEHAARQYVDNIVQVT----GEPQP-LPSEVRHA
LLRVTQSAAANIKLHAHANHASVTVGYLPDAVTLDVFDDGRGFDPAAVP-PPSA---NGGYGLRAMRQRVEQLGGELSVESSPGEGTIIAAQFPLTAP
>tr|D9WTQ9|D9WTQ9_9ACTO Putative signal transduction histidine kinase OX=457427 OS=Streptomyces himastatinicus ATCC 53653. GN=SSOG_08167 PE=4 SV=1
-------ADPDARWLRAVMDGAFFLLLGSSLIRFLTRDHEGTHTGSAVALFAAFGLLYVLGRLLAPAPRPRHLTWLGAVSVVWAGLLAISPSATWCAMPL
LFTGLQTLPVRTAVPLAAVLTVLVVATELRLSHELNPNVVIAPLAISAVATAVLVHLQRQAARQRVLIDDLVRTRRDLAATERREGILAERQRLASEIHD
TLAQGLSSQQMLLQAADRTWTTDPDAARRHMRDAAGIASRSLAEARRFVHDLAPADLA-DRTLAEALRALADRECGEGLTVGFRLDGVPGP-VPDRVEAA
LLRIAQGALANVREHAWATRAALTLTWLDDQISLDIADNGRGFD--RTPD-TGR---ERGHGLPAMRVRARQLGGTLTVESTRGEGTVVSAAVPL---
>tr|F2R204|F2R204_STRVP Histidine autokinase OX=953739 OS=JCM 4526 / NBRC 13096 / PD 04745). GN= PE=4 SV=1
-------TEQGDGWLRILLYVAFLLLLGSALARFLIRHTGENLAPWVVSLAVALAVLYLLDPLLGRRPTTLRHIWLGTVVAVWMALVWLAPSFGWCAVPL
FIIGLRTLRPPAAIALIALVTATSVTAHLRLSGRLDVDVVLAPPAIAAIAVAVFVQMDRQSRRQRELIDDLIRTRRELAATERREGILAERQRLSMEIHD
SLAQGLSSQQMLLQASDRVWDTDPATARTHVRTATAIAEHNLTEARRFVHDLAPADLADGKNLDHALRTLADRETGDRLTVLCHIDGAPTSPLPDRVQST
LLRIAQGALANVREHSGATTAALTLTYLDDQVVLDVSDNGHGFDTTHPDDTPTRG--PRGHGLPAIRTRTHQLGGTLTIESLPNEGTVLSAAIPLA--
>tr|D3PYN5|D3PYN5_STANL Histidine kinase OX=446470 OS=102104 / LLR-40K-21). GN= PE=4 SV=1
--------MNARLWVDRAMHAAFFLLLASSAARLVARHEVTGLTVAALVGSLLLAVVYAGGA-A------WRYVWFGAVVVLWLVTVELAPSFAWCAVPL
YFLALRLLPGRVTIAVAVVLTLAVIVGGVRIADVVEPSLFLAPIGIAVMIAAFFWLLNHEITQRQRLIDDLAATRDSLAASQREAGMLAERERLSREIHD
TLAQGLSSMGMLLQAAGRVWGTDPDAAREHVERAGAVAAENLDEARRFVRDLRPPRLD-DTSLAEALRVLCADVDRENVAVRFRLEGVETT-VDDRVRLA
VLRVAQSALSNVVEHAGASAAVVTLSFLGAELSLDVVDDGAGFARADVGSGSGP---QRGYGIPGMRDRLAELGGELTIENTPGEGTALAARIPLPPE
>tr|F2RG11|F2RG11_STRVP Histidine autokinase OX=953739 OS=JCM 4526 / NBRC 13096 / PD 04745). GN= PE=4 SV=1
-------QDPDAPWLARVMHIAFFLLLGASLARFLLRHPWEDRSPWIVALSGALASLYLLGPVVGTRAAPRRIAWLGTVVAVWILLVVLAPSFAWCAVPL
FYTGLRTLPARAALGLVTLLTAFVVFAQVQLAGGWDPNLIVAPPAVAAIATGVFVYSDRQAARQRALIDDLIRTRRELAAIERREGTLAERQRLSMEIHD
TLAQGLSSQQMLLQAADRTWDSDPATARRHVRTAESIAERNLAEARRFVHDLAPADLAEGGGLEAALRGLAAREAAAF---RV---DGAAVPLPERVQSA
LLRIAQGALANIREHAAADSAALTLTYLDDQVVLDIADDGRGFDPV---ETPGG---VRGHGLPAMRVRAAQLGGTLTVESAPGEGTVLSAAIPL-PL
>tr|G2GFK4|G2GFK4_9ACTO Histidine autokinase OX=700597 OS=Streptomyces zinciresistens K42. GN=SZN_21441 PE=4 SV=1
-------DTVDGRWLGAVMHTAFFLLLGGALARFLLRHPGQPRTPWIIALCVVLAVLHLLGPRAGRAGPRRQAAWLASVVVVWMVLVVLAPSFAWCAVPL
FYTGLRTLPQRAALVLVAVLTVFVVATQVQLAGSFDPNLVLAPPAVAALATAVFLQMERHTARQRVLIDDLIRTRHELAASERREGALAERERLSMEIHD
TLAQGLSSQRMLLQAADRVWESEPDKARAHVRTAASVAEHHLAEARRFVHDLAPADLARGGDLAEALRALAARESGPRLTVRVAVDGEERLPLPDAVQSA
LLRVAQGALANVREHAGAGTAVLTLTLLDDTVVLDVGDDGRGFDPASPPRSPGA---DRGHGLPAIRARLRALGGTLTVESAPGEGTVLSAAVPLE--
>tr|B8HBF6|B8HBF6_ARTCA Histidine kinase OX=452863 OS=JCM 12360). GN= PE=4 SV=1
-------SRPAGGSIDTAVHAGFAVLLVASTVRYVMRHPPADN-VLVLCLAAAASLLYAGVAVLA----RL--AWMSALVAVWAALVIAAPSFAWCSFAL
FFLCRAAISGVASYVAAGIIAVSTAAGLFRLSGGTDLAMLLGPLAVGAMLTLIHDRIRSDAEEQRRLHAEVSTAQGQLAASERRAGTIAERERVSREIHD
TVTQGLASSLLLLEAAGRTWPAPA--AHADLRQATSLLRDNLAETRSLVHDLASPGLE-GSPLPEALLTAARRYLPEALLVT----GEPRP-VAADVRHT
LLRVVQSAASNVRLHASATTATLTLGFLPDAVTLDVYDDGAGFDPAAAA-PPSD---AGGYGLRAMRQRVEQLGGTFSVESAPGEGTVVAAQLPAGGR
>tr|B5I5C0|B5I5C0_9ACTO Histidine autokinase OX=463191 OS=Streptomyces sviceus ATCC 29083. GN=SSEG_10050 PE=4 SV=1
-------TDPDERWLGAIVHGAFFLLLGSSFARFLSRDQGGARTGWVTALFAFFCLLYVLGHLLAPPPRPRHLVWLGSVTAVWVVLLVLAPSATWCVMPL
LFAGLHALPPRIAVPAAAVLTALVVLSEIRVADGLNPNMVVAPPAVAAVATAVLVHLQRQGARQRVLIGDLVRTRHELAATERRAGVLAERQRLSAEIHD
TLAQELSSQRMLLQAAERVWGTDQGAGRKHVRAAAEIASRSLAEARRFVHDLAPADLA-ERSLAEALGELARRESGPGLTVEFRLDGEQGP-LPERVAAA
LLRIAQGALANVREHAAATRAALTLTWLDEQVSLDVADNGRGFEQAGSPGAEGS---TRGHGLPAMRIRARQVGGTLTVESTPGEGTVVSAAVPLV--
>tr|L2T5X0|L2T5X0_9NOCA Sensor kinase, two-component system OX=1195242 OS=Rhodococcus wratislaviensis IFP 2016. GN=Rwratislav_48509 PE=4 SV=1
-------DRSDGGPLATAIHVSFYVLLATSTARYLTYHGVSGQ-FVVVVLIAALAALYTVTAVVA----RVWEPWVWPVLTTWAVLVWLAPSFAWCAFPM
FFLCTRAYPSRIAYPVVGVLAVLTSLAFFTFSGRSEWAVLVGPLCTGALIVMAYSQIERDGRERVRLLRQVAETRSRLAETEREAGMLAERERLAREIHD
TVTQGLTSSLLRLEAAEQIWAQADPRAREDVRVATGTLRENLAETRSLVHHLAAPNLE-SQPLDAALLAAARTHHPRALRIV----GTPIA-IPAEVTHA
LLRITQSAVSNIARHAHAETVGVTLTYLPDAVVLDIFDDGAGFEPAPAG-TLSA---RGGYGLRAMRGRVEQLGGTFTVESAPGEGTVVAAQIPCA--
>tr|E4NAH9|E4NAH9_KITSK Putative two-component system sensor kinase OX=452652 OS=A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae). GN= PE=4 SV=1
--------DPDAGWLTVVMRLAFLLLLGTSLHRYLAHHLYSPLTPWVVGLSLALVAGHL------TGLSERRPAWLAAVLACWAVLVLMAPSFAWCAVPL
VYTVLRALPPRAAIPLVTVLTVLVVVSELRLPGGFDPTMVLLPPAVAALATAVFLYMQRQGARQRKLITDLIRTRRELAAVERRQGALAERERLSVEIHD
TLAQGLSSQQMLLQAAERTWRHDPEAALEHVRTAASIAARNLAEARRFVHDLAPADLAEQGTLEAALEALADREAAEGLTVRFHLDGTPAP-MPAAAQSA
LLRIAQGALANTREHARAGQATITLSYLGDQAVLDVADDGCGFAPGRTG-RGEQRAGSRGHGLPAMRARLRQLGGTLTVESAPGEGTVVSAAIPLA--
>tr|D9V119|D9V119_9ACTO Two component system histidine kinase OX=591158 OS=Streptomyces sp. AA4. GN=SSMG_02449 PE=4 SV=1
--------MNPQTLDRRVLRVCLHLLLAGLLVLAVARAFAEGQPPAVLAGALAMGGVYTVGP-LLPRIGR----WLAVLGVAWLVLLWLTPDGVWLAFPL
YFLQMHLLPGPAVVALTTVLAIAGFTGGFSVGVLLGPTL-----GAAVAIATVYQVLYRESEQRRQLIEELRETRNDLAAMEHSAGVLAERERLAREIHD
TLAQGLSSIHLLLRAAERALPDRPEAAVPHVAQARQAAQDNLTEARRLVYALAPVELE-GASLPAALERLCATTQQRSLTVHFHLSGTPFD-VPTAYEVA
LLRIAQSALANTVRHAAASRAELTLSYMDTSITLDAVDDGIGFDSQEVRGGSG-------FGLPAMRARARSLGGSWTVESAPGNGTALAVSFPVDSR
>tr|I2N0T0|I2N0T0_9ACTO Integral membrane sensor signal transduction histidine kinase OX=1114943 OS=Streptomyces tsukubaensis NRRL18488. GN= PE=4 SV=1
-------ARRDDRWLDTLMNVAFLTLLCGALLRFLINHPDSPRLPWVIGLSAALAVLQLAGPRSRTGPRRAELLRFGLSVGCWVVVVLLAPSFAWCAVPL
IYTGLRALPERGALALVAVLSTLVVYAEWQLRTGIDPNLFLLPPTVAALATGVFLYMRRQADRLRALVDDLIRTRRELAATERREGTLAERQRLSMEIHD
TLAQGLSSQQMLLQAAERTWDSDPATARGHVRTAESIAERSLAEARRFVHDLAPADLAEGGGLAQALRALAGRESDGALRVRVLVDGAPAAPLPARVQSE
LLRIAQGALANVREHAAASLATITLTHLGDQVLLDVADDGRGFPAAEL--------------------------------------------------
>tr|D6K8A4|D6K8A4_9ACTO Signal transduction histidine kinase OX=645465 OS=Streptomyces sp. e14. GN=SSTG_04463 PE=4 SV=1
-----------------------------SSADARRREHPCRRRRPPADTAPAHD---------ATAPAPPALLRLGALVDVWTVLVALAPSFAWCAVPL
FYTALRTLPTRAAYTLVALFTVFVVVAQLRLADRLDVDLVVGPPAVAVLATAVFTHMDRQAARQAALIRDLVRTRRELAAIERREGTLAERQRLAMEIHD
TLAQSLSSQRMLLQAAERVWETDPERARAHVGTAAGIAESSLAEARRFVHDLAPADLAGGGGLDAALRGLAARESTAERTVTCLIDGAPGTPLPDRVQSA
LLRIAQGALANVREHSGATRAALTLTYLEDEVRLDIADDGRGLDPAALPERAAG---VRGHGLPAIRARVRRLGGTLTVESAPGDGTVVSAAVPLRPE
>tr|G0PWM5|G0PWM5_STRGR Integral membrane sensor signal transduction histidine kinase OX=649189 OS=Streptomyces griseus XylebKG-1. GN=SACT1_4322 PE=4 SV=1
------GADPDARWLAFLMHAAFFLLLGASLTRFLMRHPGEARTPWIIALSITLAVLYLLGPVLGSRPTPRRLAWLGVLVLVWMVLVVLAPSFAWCAVPL
FYTGLRILPPRAALALVALLTAFVVAAQLRLAEGFDPNLVLAPPAVAAVATAVFVHMQRQAARQRELIDDLLRTRRELAATERREGTLAERQRLSMEIHD
TLAQGLSSQQMLLQAADRTWGADPEAARRHVRTATGIAERNLAEARRFVHDLAPADLAQGGGLEAALRTLAARESAQALTVHCHVEGTPAP-LPDRVQSA
LLRIAQGALANVREHSGATAAGLTLTHLDDRVVLDIGDNGRGFTAEPAT-VRGP---DTGHGLPAIRARVHQLGGSLTIESAPGEGTVLSAAIPLA--
>tr|B2GKU3|B2GKU3_KOCRD Two-component histidine kinase OX=378753 OS=DC2201). GN= PE=4 SV=1
------STPALLRVMRVSLHVSFAALLGLAVLRTAMGDASAVGTAVVLCLAGLLAFTYVLGTTVENRVARGRADWLGSVTLLWVVLALLSRDFAWVVFPL
FFLYPVLLPPVVALTGIVVLTGVVVLSQLVPAGTFTAPMAVGPAVVAVLVSYGYRALYRDARRHLRVIRQLESTRAELARRERTAGTMTERERLSREIHD
TLAQGLTSIVLVSRAAQQALEDERDVAAARLATIEDTAAANLAEARRFVRDLASPALDES--LPSALDEVCRRTEEGALTCEFSVQGTVPQ-LTDRQRTL
FIRATQSTLANVLSHARASRVVVTLEGWEDAVTLDVVDDGVGFDPRALA-RAER---DDSFGLSHLRRRAAEVGAELTVESEPRHGTAVNVRLPLR--
>tr|E2PZ08|E2PZ08_STRC2 Putative two-component system sensor kinase OX=443255 OS=NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602). GN=SCLAV_3268 PE=4 SV=1
------GADRDDRRLDAVMNTAFIALLAAALSRFLTNHWGSAEAPFVIGLSAALAVLQLAGPAVRARPGTERLRF-ALVVGCWAVTVALAPSFAWCAVPL
IYTGLRSLPTRAAVALVAVVCVWVVIAEYRLSQAFDPILFLLPPVVAALATAVFVHMRRQADRLRALIDDLIRTRRELAATERREGTLAERQRLSMEIHD
TLAQSLSSQQMLLQAAERLWDADPARSREHVRTAESIAERSLVEARRFVHDLAPADLAEGGGLAQALRALAGRESTDALRVRFHLEGT-VA-LPDQAQSA
LLRIAQGALANVREHADASDAALTLSHLDDQVVLDIADNGGGFVPAEVA-APGA-----GHGLAAMRARVRQLGGTLTVESAPGEGTVVSAAVPLG--
>tr|E8W6I9|E8W6I9_STRFA Integral membrane sensor signal transduction histidine kinase OX=591167 OS=Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD). GN= PE=4 SV=1
------AGDPDARWLALLMHAAFFLLLGASLARFLMRHPGEARTPWIIGLSAVLAALYLLGPVLGSRPTPRRLTWLGALVVVWMVLVVLAPSFAWCAVPL
FYTGLRILPPRAALALVALLTLFVVAAQLRLATGFDPNLVLAPPAVAAVATAVFVHMQRQAVRQRELIDDLLRTRRELAATERREGTLAERQRLSMEIHD
TLAQGLSSQQMLLQAADRSWDADPATARRHVLTATGIAERNLAEARRFVHDLAPADLAEGGGLEAALHALADRETAQALTVRCHVEGAPTT-LPDRVQSA
LLRIAQGALANVTEHAEATVAALTLTHLDDRVVLDVADNGRGFSPERQT-PRQA---GGGHGLPAMRARVQQLGGTLTVESAPGEGTVLSAAVPLA--
>tr|J7LUN9|J7LUN9_9MICC Putative signal transduction histidine kinase OX=1118963 OS=Arthrobacter sp. Rue61a. GN=ARUE_c43140 PE=4 SV=1
------GAATILRVLRVSLHVGFAVLLLVAIVRLLTGTPSPVALTAGLGLSALLAAVYLAGTVLEKRHSSDPSRWLAAVMLLWLLLLLVSSDFAWVAFPL
FFLQLHLLPRGLALPAIAGSTALLVGTLWSSDGGLQLSMILGPAVFAVVTGLAYRALFLEAENQRTVADELRRTRAELARTQHDAGMLAERERLAREIHD
TLAQGFSSIVLMGRSAEKALESDVETARESLKIVQDTASANLAEARSFVRGLRSPDLEQSG-LVDTLRRLCEKTETEALRCRFELVGAPVE-LPNTYQTT
LLRAAQASLANVWAHAHARAAVVTLSFLGAEVTLDVFDDGIGFEPSTAA-GTAR---GDGVGLQSLRERLAALDGSLEIESAPGEGTVVAVRMPL---
>tr|D3LKY5|D3LKY5_MICLU ATPase, histidine kinase-, DNA gyrase B-, and HSP90-like domain protein OX=596312 OS=Micrococcus luteus SK58. GN=HMPREF0569_2102 PE=4 SV=1
----------VLAGLRVALHVTFAALLTVGLARALADASGPFPATTLVLLTAALAGVYLAGTVLERRRWARAVAWLALVLLLWGLLVAHHGDFAWVAFPL
FFVVLHVVGRRHVVGPVMVVAMAVVVVAGMASGGVRVPAVIGPAAVAVVLSEAYRALHAESERQRAVAEQLRAAQAELARTEHRAGVSAERERLAREIHD
TLTQGLASIVLVSRAAQDALDADPALARQRMETVRATAVENLAESRRFVRDLRGTG---APSLVEALERAVAGFAGTPVAADVEVVGEPVA-VAEAVETA
VLRAVQASLANVGAHAGARRARVTLGYLGDELTVDVADDGAGFDPAGADPGA-----GTGVGLASVRERLAAVGGEATVESAPGEGTVVALRVPLA--
>tr|H8E8V6|H8E8V6_9MICO ATP-binding region ATPase domain protein OX=1160710 OS=Microbacterium laevaniformans OR221. GN=OR221_0036 PE=4 SV=1
----------VLGSRR-SILVLATIAFLTTAIQVLMKAVGPLSLGTVTALAGLITALQSASLLLAPRWP--------GLAALGTVVFVLLSVPTWMPFVV
AVAMFLLASRSAAWLALVVAAASGLLGWALSTGPAGALLAFVAVAFIAPVVGATALGAWWGVRSRRVEAELAAASRAQEERIAQA-RIQERLAIAQELHD
VAAQHLAGLLSLADAAIEVDLRDPARALALIEDMRLEGRYASASLYAALRDLRAVGE--EDVALTPDLRQVPDLRGMRLEARL--ANDLDD-LPVMVSTS
AYRGIQESLTNAAKHAPGARVRVTVATEAQHLRVRVENDGA-ADGRGPTGGV-----GLGWGLDGLRERIRLLAGTVEAGPTPEGGWIVEVVIPVL--
>tr|G2P3X2|G2P3X2_STRVO Putative signal transduction histidine kinase OX=653045 OS=Streptomyces violaceusniger Tu 4113. GN=Strvi_5142 PE=4 SV=1
----------DERWLTAVLHIAFFLLLGSSLVRYLIRDTGTPPNGWVIALFVAFGALYLPGRWPAPAPSPG---WLTAVLAAWVALLVLAPSAAWCAMPL
FFTGLHTLPTRFAVPLAAVLTALVVTSKLRFMHGFDPNALIAPPAIAAVAAAVLIHLRRQSARQRVLIDDLVRTRRDLAATERRAGILAERQRLSSEIHD
TLAQGLSSQRMLLQAADRTWETDPEAARGHMRDAAEIVSRSLAEARRFVQDLAPADLA-ERSLAQALGALA---SGAGQTVDFHLDGPLGP-LPERVAAA
LLRIAQGALANVREHAGASRAALTLTCMGDQICLDIADDGRGFDTDVPAPGAD---RSRGHGLRAMRVRVRQLGGTLTVESAPGEGTVVSAAIPVP--
>tr|B8HGS2|B8HGS2_ARTCA Histidine kinase OX=452863 OS=JCM 12360). GN= PE=4 SV=1
----------ILKVLRVTLHTGFAVLLGVALVRILLAG-GPLR-WLWTAVAVVLAGVYLAGTVLEKRHAEGALLWLVLVTGLWAVLLAGSADFAWLAFPI
FFLHLHLLPRGRALLTIALMTVAVIASQWVASGPPHVAAVVGPAIFAVITGLAYAALYREALNQRRAADELRRTREELARSQHEAGVLAERERLAREIHD
TLAQGLSSIVLLGRAAEQSLAGDSTAAASQLELVQRTAAENLAEARSFVRGLSSPQLE-GSTLVDALRRLCAATAGLPLRCRVEVDGDPLE-LPQPVRVT
LLRAAQASLANVREHAGARTAVVTLAFLGTEVTMDIYDDGAGFDPDAAAAAH-----GGGFGVRSLRERVAALNGSLELESAPGEGTVVAIRLPLE--
>tr|H0QTT0|H0QTT0_ARTGO Putative two-component histidine kinase OX=1077972 OS=Arthrobacter globiformis NBRC 12137. GN=ARGLB_113_00880 PE=4 SV=1
----------ILLFLRVTLHVGFAVLLGVATLGLLAGGGGPSR-YGWVAAAAALAGVYLAGTLLEKRFAAGAVLWLGIVTVLWVVLLAGSADFSWLAFPL
FFLHLHVLPRPVALVTIALLTAAVIASQWAASGAPHVAMVLGPAAFSVVTGLAYRALYRDAENQRRVADELRRTRADLAKTQHDAGVLAERERLAREIHD
TLAQGLSSILLVARAAEKSLRDDTPAAGDRLALVQQTAAENLAEARHFVRGLASPQLQ-ESSLVEALRRLCSETRGSGLRCRLQVEDVPAE-LPQPYTVT
LLRAAQASLANVREHAHAGTAVVTLAFLGNEVTLDIFDDGVGFDPTPEGRPD-----GRGFGLRSLRERVAMLGGSLDLESAPGEGTVVAVRLPLD--
>tr|D1C0H5|D1C0H5_XYLCX Histidine kinase OX=446471 OS=/ XIL07). GN= PE=4 SV=1
----------RLGRAKASALAVAGVVFCAGVAQVLSEAWGPQPFFVAVLIAGL--ALACAGIVLARLHP-----WLLAFGTYGALLF-ALDAPGWCALPL
AVTVFLLAERRGLWVGGVTLVAGGLVHWVWAAGPTSEAGLFLVAAFAPLVSGGAVLGALHGRQSRRADAEAESLRLDQERRLMQA-REGERARVAQELHD
VAAQHLAGLLSLADAAVDLSDDDPDTALALVTEVRAEGRFTAASIYGALSDLRSPEG--ERVAPTPGVGQVADLRRTAVELTV--VGDATE-LPLVVSAT
AYRAVREALANAAKYARGAAISVSVVADPTQLTVTVENGSCHATSRGEVATT-----GLGWGLAGLRQRAALLGGVLSAGPTEQGGWRVSVQIPLT--
>tr|K6W9V6|K6W9V6_9MICO Putative two-component histidine kinase OX=1184607 OS=Austwickia chelonae NBRC 105200. GN=AUCHE_16_00280 PE=4 SV=1
----------AAKALVAGQHALFALLMGVAVVRSALH--DARPGW-VVVAALAMTGWYVLGVPLSRRARTGVPAWFTVLVTGWAGLVAASREFSWVAFAL
YLLAMHVLPRRWALSAVAVIMTAVLAAQPGAPA---PGQVLGPALVAVGVAVGYQRVIAESEERRRLLEDLVSAHDELAQAQRRAGALAERARLARDIHD
TLAQGFSSIILLSRAGLGESPAATDRQRDLLARIEAVAVENLDEARRVVHALAPAPLE-EAPLPAALDRLVTRFEQCGVEAGFTVDGTTQV-IPASHEIA
LLRFAQGALANVRQHARAGRVAVTLSYLPGSTGLDVVDDGIGFAPEENRRPD-----GSGFGLRAMRERLADVGGTLVVETEPGEGTALSAMIPLP--
>tr|F0M5B6|F0M5B6_ARTPP Signal transduction histidine kinase OX=930171 OS=23796 / Sphe3). GN= PE=4 SV=1
----------ILRVLRVTLHTGFAALLVVGVVRLLAAGAGSFP-FAWTGVAVVLAGVYLTGTVLEHRHATGGLQWLAAVTVLWVLLLVGSADFAWLAFPL
FFLHLHLLPRRAALLTITLMTTAVIASQWAASGRPHAAAVVGPAAFAVITGLAYVALYREAENQRRAADELRRTRQELAASQHQAGVLAERERLAREIHD
TLAQGLSSIVLLARAADKSLADDAGTAAARMALVQQTAADNLAEARSFVRGLSSPQLH-GTTLVEALRRLCEKTRGTTLRCRLEVDGAPAD-LPQPYRVA
LLRAAQASLANVRDHAHAGTAVITLTFLGTEVTMDIYDDGIGFDPSEGGGTG-----GGGFGLRSLQERVEALRGTLDLESAPGEGTVVAIRLPLD--
>tr|H2GLD5|H2GLD5_CORDN Heme-responsive histidine kinase OX=698972 OS=Corynebacterium diphtheriae (strain INCA 402). GN= PE=4 SV=1
----------ILTVMRVSLHVMFAVLLLFGIARYLID--SPNSWFYTLAIAVILGVFYMIGTAWENRFARGSPLWLIVVVTLWALLVGTSSYFLWLMFPL
IFVMLHLRHGIQGILGVASLLAIAIAIPLVTRPDWGPAQAMGPTAFSIVIFYGYATLRNDAQHYRQLAAELLAAQQDLATSEHQAGRLEERERLSREIHD
TVAQGLSSIVILARAAHGRLDKEIEDVAQQLSVIETQASDSLAEARRFVRDLAAPAL--GDSLPIALTSTINNLLGAPLDVHLELVGDSIS-LPEPISRT
VVRVTQEGLNNVVKHAHATKAVVTLGVWEDEVSLDVVDNGIGFNPGTTERGT-----SSGFGLDGLRKRVDTVGGTLVIESDT-YGTALACRIPLT--
>tr|I4JRV5|I4JRV5_CORDP Heme-responsive histidine kinase OX=1166015 OS=Corynebacterium diphtheriae bv. intermedius str. NCTC 5011. GN= PE=4 SV=1
----------ILTVMRVSLHVMFAGLLIFGIVRYYLE--VPTDANNAIAAAITLGIFYMIGTAWENRFARGSPVWLVIIVALWAFLVGASGYFLWLMFPL
VFVMLHLKQGIRGILGVALLLAIAIAIPLATRPEWMPAQAMGPAAFSTVIFYSYTTLRNDAQHYRQLAAELLAAQQDLATSEHQAGRLEERERLSREIHD
TVAQGLSSIVILARAAHGRLDKEIEDVAQQLSVIETQASDSLAEARRFVRDLAAPAL--GDSLPIALTSTINNLLGAPLDVHLELVGDSIS-LPEPVSRT
VVRVTQEGLNNVVKHAHATKAVVTLGVWEDEVSLDVVDNGIGFNLGTTERGT-----SSGFGLDGLRKRVDTVGGTLVIESDT-YGTALACRIPLT--
>tr|J1SBL3|J1SBL3_9ACTO Integral membrane sensor signal transduction histidine kinase OX=1160718 OS=Streptomyces auratus AGR0001. GN= PE=4 SV=1
----------VLRALRSCLHLLVAALLALACVRAVAGNAPA-----VVATAVVLLALYALGPRLPRVRSS-AARWLTAVALVWLALLALTPDGVWLAFPL
FFVQLHLLPLRRSLPAVAATTLAAIAGFGWHTH-ISVGTVLGPAAVAVAVVLGYQALYRESEQRRRLIEELTATRSELAAAERAAGRLAERERLAREIHD
TLAQGLSSIQLLLRAAERVLPHQPTAALGHVRQARTTAVDNLAEARRFVQALSPPALE-AGSLPAALERLCA--RSSGLTVHCQVSGVPLA-LPTPHEVA
LLRIAQSALANTVRHAAAGRVELTLSYMDTEVALDIVDDGGGFRPAGSAAAR-----GTGFGLAAMRARARALQGTLAVESAPGEGTAIAVTLPCP--
>tr|C7MF14|C7MF14_BRAFD Signal transduction histidine kinase OX=446465 OS=Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860). GN= PE=4 SV=1
----------LATVLRGAMHLAFAVLLSLGVLRALTV--DAVPSPLALAVAALVAAIYGTGTALAHRRRDPDLLWVVALLGAWVVASLVSSAFVWIAFPL
FFLVLFSLGRVTGPLALLLVALWAVLAPLAVGAELAVGEVLGPAVFSLVAHTVWRRLLEESERNRRLVARLRAAQAELADSERRKGVAEERQRLAQDLHD
TLAQGLNSIVLMSRAARTAHPE----AGAEFSRIEDAARSNLADARGLVRDLA------ARAPQDGLEQVLRGVPGTTTRFTLRTDGEPYV-PPPAVVET
VQRAAQSLVANVLQHAQAERCVLTLAWWPDRVSLDVVDDGRGFDPAAVRRRR-----DGGDGLALLRSRIAAAGGTVAIDSRPGEGTAVGISLPMT--
>tr|K9HHI3|K9HHI3_9MICC Uncharacterized protein OX=1236550 OS=Kocuria palustris PEL. GN=C884_2328 PE=4 SV=1
--------------MRVILHVSFAGLLGLAVGRFLIG--ASWPGALWPLALSLLLGLYLSGTVAEHRAFLGAGVWLAAVLVLWCLLALRAPDFSWVVFPL
FFVVQAVLPTMPSLIAVAGLTAVVIATQALHAGGFGTGQVIGPAVFAVIAAWAYRALWRDAQRHRRTVVALQAAREELAHREHRAGVLAERDRLSREIHD
TLAQGLASIVLFSRAAQDSLAQRPDAAAEQLRVLESTASADLAEARRFVQGLASPRL--AAGLESALRDLVDGLAGTDLSVSLRVEGEPRD-LEQATEAV
LLRAAQTCLSNVETHARASRAAVTLAYWPETVTLDVVDDGVGFDAAPHRPGR-----DGGYGLPHLRRRARELGGQLSIESRPGAGTAAALQLPAP--
>tr|I7GXY1|I7GXY1_CORUL Two-component system sensor kinase protein OX=996634 OS=Corynebacterium ulcerans 0102. GN=CULC0102_2289 PE=4 SV=1
----------ILTLLRVSLHLMFAALLGFGIIRFALN--SESPWKLIIALALGLGAFYMFGTAWENRFARGSGWWMLTITLMWALLMGTSGSFTWLMFPL
VFIALNLLPGIRGVLGVLTLLGIATIIPWLARPDWTLGQLLGPACFSVAVYYGYYVLNQDAMHYRQVAAELLAAQRDLAASEHQSGRLEERERLSREIHD
TVAQGLSSIVLLSRAAHGHLERELENVHQQLTVIEKQAGESLAEARRFVRDLAAPSL--GDSLSTALRGVINGILGCPIDAHLELVGDETS-LPEPVTRT
ALRVAQEGLNNVVKHAQASKAVVTLGIWEDEVSIDVVDNGLGFDLDASGEQT-----EGGFGLEGLKKRISTVGGTLVIESDE-YGTALACRIPLT--
>tr|F3NPH8|F3NPH8_9ACTO Histidine autokinase OX=996637 OS=Streptomyces griseoaurantiacus M045. GN=SGM_5042 PE=4 SV=1
----------DARWLGAVLHTAFLALLCSSFVRFLTHDNGGTHSALTVALFVAFPLLYATGRLLAPAPAPG---WLGAVTTAWALLLVQAPSATWCAMPL
LFTGLHALPPRLAVPLVALLTALVVGSEIRVSHTLNPNMVVAPPAIAAVATAVLVHLQRQSARRRRLIDDLVRTRRDLAATERRAGVLAERHRLSAEIHD
TLAQGLSSQRMLLQAAERLWPTDPARATAHLREATGLTAHNLAEARRLVQDLGPADLT-EHSLPGALQALA---SRAGLAVEFRLDGTPGP-LPDRVEAT
LLRIAQGALANVREHADATRAALTLTCLDDRIALDVADNGRGFDPARPDPAS-----GRGHGLPAMRIRARQAGGTLTVESGPGEGTVVTATTP-A--
>tr|H0QIM9|H0QIM9_ARTGO Putative two-component histidine kinase OX=1077972 OS=Arthrobacter globiformis NBRC 12137. GN=ARGLB_027_00090 PE=4 SV=1
----------RLGRIDAAVHLGFAVLMVASVVRYVMRH-SAQDNQLVLALAAAACALYAVIAVLAQRRRPW---WMFVLVAVWAVLVVSAPSFAWCSFAL
FFLCRIAFTGTVAYAAAGATAAATAAGLFRLS-GSDLAMLLGPLAVGVLLTLIYDRIEHDAAEQRRLHHEVSLAQGQLAASERRAGTIAERERVSREIHD
TVTQGLASSLLLLEAANRAWP-EPA-SRQDLRQASELLRRNLSDTRSLVHELASPGLD-ASPLPDALQAAS---PDARLLV----TGEPRA-VPAEVRHT
LLRVVQSAAANIKLHASADTTTITLGFLPDAVTLDIYDDGTGFDPAVAPPSD-----AGGYGLRAMRQRVEQLGGVFSVESAPGEGTVVAAQLPAK--
>tr|J7L898|J7L898_NOCAA Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein OX=1205910 OS=Nocardiopsis alba (strain ATCC BAA-2165 / BE74). GN= PE=4 SV=1
----------MLRALRLLLHACFLFLLGWATVRYAAGGGGAHPAWIVLCGAILLGLVYCLGALAVRHGAH-SLVWLAAVTALWALLAWADPDFVWLAFPL
YFLHLHLLRGAHSVVAVVVITGTVVLGQALHQG-LTAGMVLGPAMFALAIAAGYTALYRESERRRELIDTLTRTRDELAASQRRAGVLDERERLSREIHD
TLAQGLSGIVLLLRSAENALPDDPDLAVTRIAEARESASDNLAEARGFVRDLAPPSLT-GANLPEALRRLCA--RADGVEHRFRLDGAPVE-LPPGYEVA
LLRAAQAGLANVAAHAHATTVVVTLGYLDEEVTLDVYDDGVGFVPEPDG---------TGYGIAALRERVAALGGALEVESVPGEGTAVAVRLPLT--
>tr|D9VPD5|D9VPD5_9ACTO Predicted protein OX=253839 OS=Streptomyces sp. C. GN=SSNG_05730 PE=4 SV=1
----------VTRVLRLCLHALLLGLLALASARAVADRAGW-----VTGLCVLLAAVYAAGVRAPAVHRS-AGLWLAGVGAVWAALLVLSPDGLWVAFPL
YFLELHLLRLRWALAAVGVTACAAIGGFLAHGG-LTPGAFLGPGAVAVATVLGYQALYRESERRRELIEELIATRAELAAAERSAGILAERERLAREIHD
TLAQGLSSIQLLLRAAERALPEDAPAA-DHIARAREAAQDNLAEARRFVRALTPPDLE-HGSLAAALERLCS--GAPGPRVRFSVSGAPRA-LPTPYEVA
LLRIAQSALANVVRHAGAGRAEITLTFMDSSVTLDVVDDGRGFDPAGDG----------GFGLPAMRARAESLGGLFTVESDPGQGTAVAVTLPLP--
>tr|A7VMY4|A7VMY4_STRKA Putative two-component system sensor kinase OX=1946 OS=Streptomyces kasugaensis. GN= PE=4 SV=1
-----------------MLHGAFFLLLGSSLARFLIRHSGSAQLPWITALSVVLAVLYVLGPGRDLRPAPR---WLCAVVTIWVVLVVLAPSFAWCAVPL
FYTGLRTLRPRAAIGLLTLLVILVVVAQLELS-RFDPDLVFAPPAVAAIATGVFIRMERQSARQRRLIDDLIRTRRELAASERREGMLAERQRLSMEIHD
TLAQGLSSQQMLLQAAARIWGTDPVKARAHVRTAESIAEHNLTEARRFVHDLAPADLAGAGGLDEALRALA---SGDRLTVRVHIDGSRSPRLPDRVQSA
LLRIAQGALANVREHSGATTAALTLTLLDDQAVLDVADDGCGFDAAPPGTAAG----VRGHGLPAMRARVGQLGGTLTIESAPGEGAVLSAAIPLE--
>tr|E2S3E1|E2S3E1_9CORY Histidine kinase ChrS OX=525264 OS=Corynebacterium pseudogenitalium ATCC 33035. GN= PE=4 SV=1
----------GQKLWVYGLHAMFAFLLVFGVTRAYVD----DRLDAVIGLAITLAVVYS-AQRWLPTW-----LWLGGLCLLWLGLMVHAQDFMWLEFPL
IFVFLRALPTMPGLVSIAVLWAAAAFIPAWLHPGWSIAAAVGPTAFAATVFFIQRRLQAEAAHHRDIAKQLRETQAELAASEHQAGRLEERERLSREIHD
TVAQGLSSILLLSRAARGTDDPTKEE---QLAVIEDVASENLAEARRFVRELAGP----DERLETQLTSLLSQMLGK--ETTFELVVSSGK-VPECIKEV
IVRAAQEGLNNVIKHAHASRAVVTLGLFEDAVTLDVVDNGCGLSASPRPSGG-----DHGFGLTGLRDRVEAVGGTMNLESGE--GTALAVRIPLK--
>tr|L7EWF4|L7EWF4_9ACTO Histidine kinase OX=698760 OS=Streptomyces turgidiscabies Car8. GN=STRTUCAR8_09455 PE=4 SV=1
--------VRGRRFLEHVPHLAFFVIVASALLQLAQIN-S-ELCWYIATVSGLLALVYTGGVAWDRFGAVGRATWIPLLLVLWGLLLALISAFVWCALPL
ACAAQRVLGRRSAAVALAVITLVLVVALAGADGRLVTEAVVVPVAAVWGTVALYRVQQRDAEARRLLVEELRDTRELVARQQRRAGVLAERTRIARDLHD
TLAQELAGGLMLLQAAERDWDERPDAARSRVRAVADGLGTNLAETRRMIRDLTPSSVA-ETGIESALRVLCARSQATAAQVRFRSVGDPQPVLDEHAATT
LFRVAQSTLANVREHAHAVNVQVTLSRRPDQVDLEVSDDGVGFDPAEVFARTSG---PRGFGLPAARARLREYGGDLDVSGAPGRGTRIRATVTAG--
>tr|L1KLL4|L1KLL4_9ACTO Histidine kinase OX=698759 OS=Streptomyces ipomoeae 91-03. GN=STRIP9103_08919 PE=4 SV=1
--------VRRGSLLRRLPDLVFLAVVGGGLLRLVDQNRYSTLCWELLPLITLLAAGYVGGLLWDRLGRRGRPLWLAALLVLWWWISWEATSYIWLALPL
AILALRMFRDRTAVAVVAVITVLLVVLIARTAEVLHPELVAPPAAALWATVALYRSQQR-------LLGELRRTRAELARGQREAGRLAERARIARDLHD
TLAQELAGSRMLLQAADRDWDRRPDLARTQVRTVADALGANLAETRTIIRDLTPPALE-HDDLAAALRSLCARDSATPSRVVFRTEGEPGH-LPCEGAAA
LLRVAQGLLANAREHAHARHVWVTLDHDDTTVTLEVRDDGVGFDPAAASTSASR---PRGLGLTAGRERLHALGGSLTVRSAPGRGTLARATLPLN--
>tr|E1VWP3|E1VWP3_ARTAR Putative signal transduction histidine kinase OX=861360 OS=Re117). GN= PE=4 SV=1
--------HRYFGSLRWGQHLVTFILVLIVLLRVFASG---QHPWLSLGLSILFVAWYSAGFIRMARSQAKLLPWLAVLLVIWVASLASSPEFMWLAFSL
WLLLGHQLPLLPSILWSVVVYAFTLLAPYLHNLEVTLAAAAGPLVGGLFAWGIYLQMERDAEVRTSLVDSLVRAQGELARSQHEAGIATERTRLAREIHD
TVAQQLSSIGLHAKAASKDPA----AATAALSRIDELSGQALTDLRRIIAALAPAELD-SQALAGALGRILENFKTSKLQTRLDIEPGLPA-LHPNVQIA
LLRTAQSALSNVLRHAQASTVALSLGSSGDEVRLDIVDDGIGFIPNTGRTQTSTH--TGGFGLTAMNQRLRELGGGLDVESSPGEGTALCAHLPL---
>tr|C9Z0E1|C9Z0E1_STRSW Putative two component system sensor kinase OX=680198 OS=Streptomyces scabies (strain 87.22) (Streptomyces scabiei). GN= PE=4 SV=1
--------VRRNPLPGRLPDALFLTVVVGGVVGLVDRN-A-AACWELVPLIMALAAGYVAGLLWDRLGRRGRPLWLGSLLALWCWISWAATAYTWLALPL
AILALRVFTGRTGIVAVAGITVLLVLLIAHASGNPHPELVVPPAVALWVTVALYRAQQR-------LLGELRCTRAELARGQREAGRLAERARIARDLHD
TLAQELAGSRMLLQAADRDWDRRPDLARTQVRTVVDALGANLAETRTIIGDLTPPALE-HDDLSTALRTLCARTTATPSRVLFRTAGEPGD-LPRDRAAA
LLRVAQGLLANACEHARARHVWVTLDHDDTAVTVEVRDDGVGFEPREAGRGRR-----RGLGLPAGRARLGALGGSLTVRSAPGRGTLARASLPVG--
>tr|L7LP09|L7LP09_9ACTO Putative two-component histidine kinase OX=1223544 OS=Gordonia sihwensis NBRC 108236. GN=GSI01S_39_00110 PE=4 SV=1
----------AERYAEWGGHILFLALLLAGMAQALAGSAPFGGAAAVIAGVAVVGGWYLLGVSHTRGRGLDTGIWVVILTLLWVALVLLSPGFVWLAFVL
AMLCWYFLEPPVSVVAEVVIVTTSIGSTLLHSPELMVGGIIGPAFGIATAVAVFRRIIAMVDERDELVADLLATRELLAAKERQAGILAERERLGGEIHD
GTGQSLASIVLLLRSATNDET--PGDQRDQVRTALDTAQKALTESRRFLRGLDGPDLR-PDGLTDALREEVD-RVSSGLPAELRVHGDTVA-LRPETRNT
LLRTAQEALTNAARHAHATRATVTLTYLPDEVHLDVVDDGVGFRPPRRSD-------GSGFGLRAMQNRVSEAGGSVSVESEPDDGTVIHARLPIG--
>tr|E8RXV3|E8RXV3_MICSL Integral membrane sensor signal transduction histidine kinase OX=648999 OS=Micromonospora sp. (strain L5). GN= PE=4 SV=1
--------TPTTRALAWCLHLLIIGLLVLAAGRAVADDR--PRAGSIVAASVACGLAYAIGPLLPRIRRSRWAAWLAAVGAAWLVLLGLSPDAIWVAFPL
YFLQLHLLPRRAGLAAVIATAAAAVAGFGAHTGSFTAATVIGPALGAAVAVGVYQALYRESEQRRQLIEELTATRADLARAEHTAGVLAERERLAREIHD
TLAQGLSSIQLLLRAAERALPGRPGAASGHVDAARQVAVDNLAEARRFVAALTPPTLE-GTTLAGALERLCTTTSAHRLAARFHLVGAPVS-LSTAHEVA
LLRIAQSALANTVRHARATTAEVTLSCLGDRIALHVVDNGQGFDPDRLPAPDVD---SGGFGLTAMRARMNALGGTLAVESAPGHGTALTAELPLT--
>tr|H5XMR4|H5XMR4_9PSEU Signal transduction histidine kinase OX=882082 OS=Saccharomonospora cyanea NA-134. GN=SaccyDRAFT_2154 PE=4 SV=1
--------TPTTRALAWCLHLLVLGLLVLAAGRAVAAGD--PRAGAVVAAATACGLVYAVGPVLPHVRRSRRAAWLTAVGAAWLVLLALSADGVWVAFPL
YFLQLHLLPRRAGLVAVVLTAAAAVAGFAAHQGSFGAAMAIGPALGAAVAVAVYQALYRESEQRRRLIEELTDTRADLAAAQHTAGVLAERERLAREIHD
TLAQGLSSIQLLLRAAERALPGTPETAAGYVDQARQAAVDNLAEARRFVAALAPPALE-DTTLAGALERLCATTSTHPITARFRLSGEAVP-LPTAHEVA
LLRIVQSAIANTVRHAHATSAEVTLRYLGDRVEVDVVDDGRGFVPGRLPSAGPQ---TGGFGLAAMRARVQSLGGTFTVDSAPGRGTALTARLPVG--
>tr|E4WEC8|E4WEC8_RHOE1 Putative two component system sensor kinase OX=685727 OS=Rhodococcus equi (strain 103S) (Corynebacterium equi). GN= PE=4 SV=1
--------APVLRAMQIGAHFLFLLLLAIGVGRVVTKG---ADGWWIVAIAVAELLWYGCGVARNGGAVDKASGWLGILVLGWLALVVSDPNFVWLVFAL
FFLCFHLLTIPQAFGATVALTAVSITASLWHGVTETVPSIVGPLIGAAVAAGMYQLLVREAAERQLLVDELTEAQDELGALQRESGALEERSRLARDIHD
TLAQGFSSILLLARAGRRG-N----DAAPIFDQIADTAQENLVEARRVVAALAPADLE-SAPLESALRRLVAQLGDTGIIGEVHTDGEDVP-LPMDYDVA
LLRVAQSSLANVRLHSRAQRVRVTLTYEADEVRLDVVDDGIGFDTRE----------AGGFGLRAMRERLAELGGTLVVESAPNDGTAVAATLPV---
>tr|I0V0L6|I0V0L6_9PSEU Signal transduction histidine kinase OX=882086 OS=Saccharomonospora xinjiangensis XJ-54. GN=SacxiDRAFT_1418 PE=4 SV=1
--------LTVVRGF---LHSLVAVLLVLACVRAVTTG---VNGAAVVAVCAVFAAVYAAAGLRPLDVTSRRGAWLAALGVVWLALLILTPDAIWVAFPL
FVLQLSLLPAHWGVATVALTTALAIGGFGWHQHALTSGMILGPLLGATVSVIGYQALHRESERRRRLLDELTATRAELAAAERSAGVLAERERLAREIHD
TVAQGLSSIQLLLRAAQRSLATGAPGAAGHIERARQAAADNLAEARRFVRDWSPPILE-GRSLPDALDTLCATTADSGLLVNLHVSGTPFP-LPTTAETT
LWRVAQSALANVVRHAEAGTAEVTLSYMDTEVALDVVDDGVGFDPGAQPAPGVD---GAGYGLAAMRARARAAGGDLVVESAPGRGTAVAVTLPCR--
>tr|Q9AK93|Q9AK93_STRCO Putative two component system histidine kinase OX=100226 OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). GN= PE=4 SV=1
--------TPTSRALAWCLHLLVVGLLVLVAARAVTDGR--TPTATIVAVAVACGLVYAAGPLLPRVRLVRRVAWLTAVGAVWLALLALSPEAVWVAFPL
YFLQLHLLSRRAGLAAVTATAVAAVAGFAAHTGSFGPAMVIGPTLGAAVAAAVYQALYRESERRRRLIEALTATRADLARAQHTAGVLAERERLAREIHD
TLAQGLSSIQLLLRAAERALPERPGTAAGHVVAARRAAVDSLAEARRFVAALTPPALE-GTTLADALERLCATARVHRITTRFHLAGTPVP-LPTAHEVA
LLRVAQSALANTVRHADAGTAEITLSHLGDHVALDVVDDGTGFDPDALPPPDPE---AGGFGLAAMRARLDALGGTLSIESAPGHGTALAARLPLV--
>tr|F1YGY0|F1YGY0_9ACTO Histidine kinase OX=644548 OS=Gordonia neofelifaecis NRRL B-59395. GN=SCNU_05491 PE=4 SV=1
--------------VRRLDAWLFVVLV--ALVVTSSLR-Y-VLRHGLGTVGVLILLGAAALIGYAVRPLLPQRTWIP---AAWSVALAAAPSFAWCAVPV
AFAVLRTLPYLWAVVCVSALVVVVTASWLRISPMLDPVVIAGPLGIALITVMSFRALDLEAKARAELIDRLVATQDDLAAEQRRVGALRERARLSRDIHD
SIGQDLSSVYLLLQAADRGWTAEPATSHDNVRTAIDASRRGLEEIRHVIHDLSASLIT-AAELHQRLGDLREHSHG-SAQVSLRIDGAPVP-LSHRSSSA
LVATARGALANVQEHSGADRAMMTLTYTPDEVRLDIRDDGRGFDPQRARSTPGS---PRGLGLKGIRDRVVELGGGADVESEIGDGTTVSVWFPIG--
>tr|C1AZX4|C1AZX4_RHOOB Two-component histidine kinase OX=632772 OS=Rhodococcus opacus (strain B4). GN= PE=4 SV=1
--------EGLRGPLGTAIHVSFYVLLATSTARYLTYHG--VSGQFVVVVALIAALAALYASTVVVARRGGAWEWVWPVLTTWAVLVWLAPSFAWCAFPM
FFLCTRAYPSRIAYPVVGVLAVLTSVAFFTFSGRTEWAVLVGPLCTGAL---IYSQIERDGRERVRLLRQVAETRSRLAETEREAGVLAERERLAREIHD
TVTQGLTSSLLRLEAAEQIWAQADPRAREDVRVATGTLRENLAETRSLVHHLAAPNLE-SQPIDAAL--LAAARS-HHPRAELRIVGTPIA-IPAEVAHA
LLRITQSAVSNITRHARAETVGVTLTYLPDAVALDIYDDGAGFDPAPTAPPT-D---RGGYGLRAMRSRVEQLGGKFTVESAPGEGTVVAAQIPCG--
>tr|B4V298|B4V298_9ACTO Two component system histidine kinase OX=465541 OS=Streptomyces sp. Mg1. GN=SSAG_01917 PE=4 SV=1
--------TPVSRVLRLCLHALFLGLLGLAAGRAVTGPE--PHAGWTVAVCALLAAGYLAGALAPAVRNSPRAGWLAGLGAAWAALLALSPDGLWLAFPL
YFLELHLLRLRWAIPAALVTAAAAIGGFLGHSGAVTPGPFLGPLLGGAVAVATYEALYRESERRRELIEELITTRAELAAAERDAGILAERERLAREIHD
TLAQGLSSIQLLLRAAERTLP-QEAPALPHIARARRAAQENLAEARRFVRALTPPDLE-HGSLPAALERLCSAVRGR---VRFSLSGTARV-LPTPYEVA
LLRIAQSALANVGRHAAAERAEITLTFMDASVTLDIVDDGTGFDPGAARAGG-----EGGFGLPAMRSRAESLGGLFTVESAPGQGTAVAVTLPL---
>tr|Q6AG23|Q6AG23_LEIXX Two-component system, sensor protein OX=281090 OS=Leifsonia xyli subsp. xyli (strain CTCB07). GN= PE=4 SV=1
--------TPVFTALRIGLHALVVGLLVRACVETASGDA--RQAGAVIAVALLFVFTYAAGG--PLRARMRGGLWLGALTAEWMLLAALTQDATLLVFPL
FFLFLHLLPSPWSVVAVGASTVAAILLFAAHS-GWTAGGVLGPAIGAGVAVAIYRALFQEAQEREQLIRDLVATREQLAASERSAGTLAERSRLARELHD
TVAQGLSSIQLLLHAAERFTT--EPAALDAVRLARETAAADLAETRRFIHALTPPALE-DKTLPGALRRLAGQTERSGLRVTVSVSGEPSP-LPMPVETA
LLRSAQGSLANVVQHAEATAARLTLTYDDDAVTLDIVDDGRGFDTATAGGGERH---PGSFGLRAMRERAAGLGGEVAIESATGRGTAVAVTVPTG--
>tr|B0RCJ5|B0RCJ5_CLAMS Putative two component sensor kinase OX=31964 OS=9667). GN= PE=4 SV=1
--------SPVFVGLRTGLHVLVAALLALVVVRVLVADG--PRTGIALALAAAFAVLYLLGARVRLVRVSRRAAWITALTAAWIALLVLVPDAAYLVFPL
FFLYLHALPRAVGPVAVVVATLVAVVALGLH-GGFTIGGVIGPLVGAGVALLIYRALARESAEREALLAELIATRDLLAATEREQGVLTERARLAREIHD
TVAQGLSSIQMLLHAAEAADGDRPG--LDHIRLARATAADGLADTRRFIRELAPPSLD-AG-LGAALGRLSAQWR-EGLRIDVAVPPLESP-LPMDVQTA
LLRIAQGAVANVAQHADASVVEIGLTVTAAHATLTVRDDGAGFDPARAAADAGA---SDSFGLRAMAQRVEQLGGTLDVDSAPGRGTIITAVLGVG--
>tr|H0JLG1|H0JLG1_9NOCA Two component system sensor kinase OX=1114960 OS=Rhodococcus pyridinivorans AK37. GN=AK37_02108 PE=4 SV=1
--------MPVLRAMQFGAHLLFFLLLAVGVVRTVTDS---AHPVPIVALAVVVAGWYLFGIFENGEPVQRRSGWFAALGLGWLALVVADVNFVWLAFAL
FFLCFPLFSTPVALTVTIMLTAIAIAATLWHGTTNTVASILGPVFGAAAAAGMYQQLVRQSAQRQQLVDELTEAQDELVALQREAGALTERSRLARDIHD
TLAQGFSSILLLSRAGQRAPD----NSAAVFAQIADTAQQNLIEARRVVDALAPVALE-SAPLESALRRLLDQLEQTGITGDLLTDSDPIP-LVTDFDVA
LLRVAQSALANVRLHSRARRVRVTLSYASDEVRLDIVDDGIGFDQRQ----------DGGFGLRSMRERLAELGGTLVVESAPGDGTAVAATLPI---
>tr|F9VYG0|F9VYG0_9ACTO Putative two-component histidine kinase OX=1027371 OS=Gordonia alkanivorans NBRC 16433. GN=GOALK_087_00470 PE=4 SV=1
----------MLRVMQVGAHLLFFLLLSVGIVRAVADS---DHPAPVVSLAAVVAAWYLCGILENGEPIERRLGWFAVLVVGWLMLMLADANFVWLAFAL
FFLCFPLFSTPIALTVTAVLTGAAIAATLWHGTTNTAASIVGPVFGAAAAAGMYQQLVRQSTQRQQLVDELTEAQDELVALQRETGALAERSRLARDIHD
TLAQGFSSILLLSRAGQRGPG----DPTAIFTQIAETAQQNLVEARRVVEALAPAALE-TAPLQSALRRLLDQLQRTGITAELITDGETMS-PIMDYDVA
LLRVAQSALANVRLHSQARRVRATLSYSSDEVRLDIVDDGIGFDQRE----------AGGFGLRSMRDRLAELGGTLVVESAPGDGTAVAATLPI---
>tr|C3PKE4|C3PKE4_CORA7 Two-component system histidine kinase OX=548476 OS=(Corynebacterium nigricans). GN= PE=4 SV=1
--------MMSNKLWTVGLHAMFGFLLVFGVLRAWADERLDARVLGLSIALAVVYTCFVI-VSRTITRPVPTTLWLAALCLLWIGLMVHAQDFMWLEFPL
VFVFIHALPFWPGIVASVILAVAAFVPAWIHPQFWTAAAAIGPFIGTCFAVAVARRVQAEAAHHEAVAKQLRETQEELAASEHQAGRLEERERLSREIHD
TVAQGLSSIVLLSRAAKNTST--QQDVTEQLALIEKVAQDNLAEARRFVKELAAPASS-IDKELRTLVDELQAQAKLGLRTYFGLKTGSAD-VPTEFSHV
ILRAAREGLTNVMKHADADRAVVTLGSFKDEITLDVADDGRGI-----EG-------PRGFGLTGLEQRVRSVGGSVQVESSPA-GTALAVRIPTG--
>tr|K9AD97|K9AD97_9MICO Signal transduction histidine kinase OX=1229781 OS=Brevibacterium casei S18. GN=C272_15647 PE=4 SV=1
--------------MEIGQHAIAVVLTVISSLRAITAG---APVLAVVAVSLVLLAWYGFGAVRAARSGSVDLAWLLVLAAIWLLMLVVSAEFIWVAFLL
WLLAGHLFSLPIAVVFTAVTYLATVAAPLIHHGSVSTPAVIGSLIGAVFALGLYIELLREGRRREELLQSLEAAQDELALTQRHAGEIEERTRVSRDIHD
TVAQEISSIRLISHADRTTDA----HAAQVLRQVEDLAAQGSRDVRRIIAALAPAELE-DAALPAAIGRLLSRLESTTILADLTVDETWPA-LPAEAEVA
LLRTAQSALANVRQHAQATRVRVSLSDLGDSIRMDIVDDGVGLADPQTRTRKT----DSGFGLDFIASRMRELGGELDIETAPGAGFAISATLPR---
>tr|E9T8A2|E9T8A2_COREQ Sensor kinase, two component system OX=525370 OS=Rhodococcus equi ATCC 33707. GN=HMPREF0724_15008 PE=4 SV=1
--------AAFRGPLGVAIHLSFYVLLAASTARYLTYHG--VSGRWLVVAGLIVVLAGLYAVIVVLSRRGGAWQWVWPVLTSWVALVWLAPSFAWTAFPI
FFLCTRAFPRWAAYLIVAALAVFAGIEFASFSGRTEWAVLLAPLCTGAL---IYGQVERDSAERERLLGELVDAKSRLAETEREAGVLSERERLAREIHD
TVTQGLTSALLHLEAADEVWDRSGPRARDEVRVATRSLRENLAETRNLVHYLSSPDLT-TQTLDAAL--LAAVRG-YVPSAQLRVIGEPVG-LPPDVEHA
LLRIVQSAASNIRRHADAHTVGVTLTYLPDAVALDVFDDGSGFVVGETS----------GFGLPAMRQRVEALGGTFSVESAPGEGTVVAAQIPVG--
>tr|L7LG11|L7LG11_9ACTO Putative two-component histidine kinase OX=1121927 OS=Gordonia hirsuta DSM 44140 = NBRC 16056. GN=GOHSU_65_00090 PE=4 SV=1
--------LTADRYIQWGGHLLFAVLVAVGLTRAIVDTD--GSVTAIVVGAALLSAWYLYGVAISVRHQAIAVPWVLILVAGWAALTALAPSFTWLAFVL
AMLSWHFLPTLLAVPVEAVIVAAAVTAALRTDP-VGVGSVIGPLIGIATAIAVVRRVIAASAAREEL------SRELVAAQLR-----VEQLRLGSEIHD
GAGQALAGIVMLLQSATDPES--PPAQRHQTVTALEMATTALAQTRGFLRGLHDPSPA-PDEVAAHLRGAVE-QARLGLPTELHIHGGVSD-LAAPAREA
LVRSAQEALANAARHSGASRAVVTLTVLEDEVHLDVVDNGTGFDPAVVGG-------GTGFGLGALTARVAECGGTASIDSEPGDGTIVHVALPAG--
>tr|E8WFN8|E8WFN8_STRFA Integral membrane sensor signal transduction histidine kinase OX=591167 OS=Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD). GN= PE=4 SV=1
----------VTTALRLCLHALLVGLLAL--TALRPTS-----GTEVVVLAGLMAALYGAGALASVQPHTAAGVWLVALGAVWLALLVLSPDALWVAFPL
YFLQLHLLPVRRGLPAVVVTAAAAIACFVLHHQAVTPGTFIGPLLGAAVAVLGYDALFRESERRRELIEELVSTRAELAEAERAAGTLAERERLAREIHD
TLAQGLSSIQLLLRAAEHTLP-VDAPATAHVRRAREAAQDNLAEARRFVRALSPPDLE-HGSLAAALSRLA-SRTSTPLTVRFAVSGTPVG-LPTPYEVA
LLRTAQSALANVVRHAGARRAGITLSFMETSVSLDVVDDGCGFDP---A-TDRG---RGGFGLPAMRARARSLGGTLSVETAPGQGTALAATLPVA--
>tr|I7L9N2|I7L9N2_9ACTN Two-component system sensor kinase OX=883169 OS=Turicella otitidis ATCC 51513. GN=BN46_1187 PE=4 SV=1
----------GEQSLTTGIHVVTSVFLVV--T-GAAAAGRPLDAAAAGIAACVFGFAYFFGSSLWRDWPRGQYAWLAVLTVLWLALMTLTTVGVYLVITL
YFVYMRVFDDWRGILAVAASTALSIA--WQIPNGLTPGAVLGPASAALVVVYAFRAVARVNVERQRLIDQLVATRGELADTQRRAGVAAERERIAHEIHD
TVAQGLSSIQMLLYAADRDLDEAAEPVARRMAQARRTAAENLAEARAMIAALQPAALT-RTSLESALRRVAESFAESGVGIDVDVDGDARQ-LPMTVEAA
ILRIAQGALGNVVKHADASACRVTLGFAPDEVRLDVVDNGKGFDPEDVA-R------VGHVGLDAIRRRAADVGGELSIESRPGGPTALSVAIPAA--
>tr|F0MAD5|F0MAD5_ARTPP Signal transduction histidine kinase OX=930171 OS=23796 / Sphe3). GN= PE=4 SV=1
----------LAG-IAAAVHLGFAVLLVASLVRYVMRHSPADNLL-VLGLAAAACLLYAVVAVLAWR----GVPWVFALVAVWAVLVIAAPSFAWCSFAL
FFLSRSALAGGAAYAAAGVTATATAAGLFRMSDGTDLAMLLGPLAVGAMLTLIYDRIQDDAQEQRRLHAEVSLAQGQLAASERRAGTIAERERVSREIHD
TVTQGLASSLLLLEAAGRAWPE--PAARADLNRATTLLRGNLSETRSLVHELASPGLD-GSALPDALLVAARQYVP---EVRLLVTGEPRP-VPAEVRHA
LLRVAQSAASNIALHSGASIATVTIGYLPDTVTLDIYDDGAGFDPAAAA-PPSN---TGGYGLRAMRQRVEQLGGTFSVQSAPGEGTIVAAQVPAP--
>tr|C3PKA7|C3PKA7_CORA7 Two-component system sensor kinase OX=548476 OS=(Corynebacterium nigricans). GN= PE=4 SV=1
-----------SDALRNGIHVLTATLLVV--AIFTTVRLPLWQGVLNLLLLVSFAVVYFGGSAYLEALPRARYGWMVILTVLWLADLAVAPAAIYLVFSL
YFVYLYVLEMIPGVICVIAATVMTVL--VQIPGGLSFGGIMGPAVSAMVTIYAFRALSSMN-------QELVKTRSQLVESERTAGMTAERQRIAHEIHD
TLAQGLSSIQMLLHAADRDLDQDIPKAQERIELARRTAADNLHEARAMIAALQPAALS-ETSLGAAMTRMADNFAATGVDVSVDVEGDTQQ-LPMKVEAA
LLRIAQGAMGNVVKHAHASKARVTVTYAPDEVRVDVVDNGQGFDVSAVN-KPAG---LGHIGLSAMRRRAEELGGEVVIESTPGSGTAVSVSVPLD--
>tr|D7W9D1|D7W9D1_9CORY Two component sensory kinase OX=585529 OS=Corynebacterium genitalium ATCC 33030. GN=HMPREF0291_10669 PE=4 SV=1
----------DNRALDTGIAALTVALLLV--SLGGVFRMHISQAVTLVLLIITFGGIYSFGALQMRRWNAARVLWMLALTAVWVAAMFLTPVAVYWVFIL
FFLFMRAFNGWYGVVGVVGVLAISIL--VQIPDGLTLGGVMGPTVSALVVIYAFKVIARVSAEREALIQELVDTQEALALKEREAGVVQERQRLAHEIHD
TVAQSLSSIQMLLHAAERDLERALASPLRRIEVARHSASDNLAETRAMIAALTPAPLS-ETSLPEALERIAGSFAQAGMDITVDVDGQPRQ-LPMRVEAG
LLRIAQGAVGNVVKHSGASMARVTLTFAPDEVRLDVVDNGQGFDVDALE-RPSG---LGHLGLDAMRTRARELGGELIIESAPSGSTALSIVVPIN--
>tr|D2PUG1|D2PUG1_KRIFD Histidine kinase OX=479435 OS=Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399). GN= PE=4 SV=1
----------ANGLVTL-LHATLVVLVAASAVRYLSGHGFGDRAPWVLAGAATLLATYAAHRVL-------SQVWLALLIAVWFGLVLLAPSFAWCAVPL
SFVALRVLPFRPACAVVAGMVVTTVVTWTRMSDRLDPTIVLGPVCVAVLAVGAYRALERDALARQALLDDLHAAQGDLADAQHRAGVLAERTRLSREIHD
SVAQGLSSINLLLQAADREWDS--AAAREHAAQAAATARDGLDEVRRVVRDLAPAELA-SGPLPAVLRQTCERLAAHSVEIRVQVHGTPVR-LDPEIETA
LLRTARGALANVLEHAAATTAVVTLTYQPDAVALDVRDDGRGLPEPPPA-DPDR-----GRGLAGIRSRLRELGGTLVLESEPGEGTALAASVPLE--
>tr|F2RCE1|F2RCE1_STRVP Hemoglobin-dependent two component system,sensory histidine kinase HrrS OX=953739 OS=JCM 4526 / NBRC 13096 / PD 04745). GN= PE=4 SV=1
----------ALRALRLCLHLLMAGLLVL--AAVRADS------AAGTVLAGVTGAVYAAGSYLSVRSSQAAAVWLAVLGASWVALLCLTPEALWVAFPL
YFLQLHLLPVRRSVPVVVLTAVAAILSYVGHGAPLNPGVFIGPLLGAAVAVLGYQALYRESERRRRLIEELIATRAELAAAERHAGTLAERERLAREIHD
TLAQGLSSIQLLLRAAERALP-PGSPAAGHIDGARRAAQDNLAEARRFVRALTPPDLE-HGSLAAALERLCQARRPGAPRVRFSVSGTPVE-LPTPYEVA
LLRIAQSALANTVRHAAAARAEITLSFMDASVTLDVVDDGAGFDPGA-V-RPSS---DGGFGLPAMRSRAESLGGTFTVESAPGQGTAVAVSLPAG--
>tr|E0DE24|E0DE24_9CORY ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein OX=553207 OS=Corynebacterium matruchotii ATCC 14266. GN=HMPREF0299_7218 PE=4 SV=1
----------GAANYRRAMNILTVALLIG--ALGAAVRTQDVQAAIVAVILCILFAFFYTMAVTRIRDRLLKIMWLAGLTAVWVIMLPIIPVSVYCVFPL
FFLYLRVLPDYRGMIAVVGATCVAIL---NFRAHLTYGAVMGPTASALVVILAFQALWKGAREREELIDELIETRSQLAATERAAGIVAERQRIAHEIHD
TLAQGLSSIQMLLRVGEQELAEEKTKVLKYMELARNTAADNLSEARAMIAALQPAALS-KTSLEGALHRVAESFV---VDWSIQVDGDERQ-LPMKTEAA
LLRIGQGAMGNVAKHANATRCAVTLTYSADEIRLDVVDDGDGFVPQDVD-RPAG---LGHIGINAMRQRAAELGGTLEVESQPGEGTAVTVALPVE--
>tr|C0XNJ5|C0XNJ5_9CORY Two component system histidine kinase OX=525263 OS=Corynebacterium lipophiloflavum DSM 44291. GN=HMPREF0298_0015 PE=4 SV=1
----------DNKALDTGITVLSASLLVV--SLLALLQMPLNSALLHIVLVSIFAFLLFYGLVEMPRWGRGQAGWLMALTGMWIADMMVTPLAVYWVFIL
FFIYLRTFNDWRGVVWVALGLGIAVG--AQVPTGLTFGGVIGPVLSALVVIYAFTTIARVSKERESLIDELLTTRQQLAETEREAGVSQERERLAHEIHD
TVAQGLSSIQMLLHAADRDLPPELARAKSRIETARRAASSNLAETRAMIAALTPAPLT-EASLRQALERIARDFSQASIGIEVESDGEHTP-LPMRCEAG
LLRIAQGAVSNAVQHSGATRIRVTLTYSPDEVRLDVVDNGRGFDPLALS-APTG---LGHLGLSAMRSRAEELGGELIVESAPGGPTAVTAAIPIN--
>tr|D2B801|D2B801_STRRD Histidine kinase OX=479432 OS=NI 9100). GN= PE=4 SV=1
----------ERGWLNWAMHLGFYLLLAASASRLVSRHGMDPRTVASLAVCGLLAVVYAAGVVLGDL----RLVWLGAVIAVWLVLVVLAPSFSWCAVPL
LFLCLRLLKPRGFMVATAALTLVVIAAQLKIAREVDPSLILAPIGVATMTAVIFWELQRESAARQRLIDDLISTRGTLADSRHRTGVLEERERLAREIHD
TLAQGLTSLGILLQAADRMWAA--ERAHAHVRRAATAAAENLDEARRFVRDLQPSGLE-GVPLPEALARLCHRTGHDTLDVRFRQEGEGYP-LEPDVQAA
LLRVAQGALANVRDHSGAETAMVTLSYLDGEITLDVFDDGAGFAE-PTP-APGR-----GYGLRAMRDRLAEVAGSLAVESAPGEGTAVAARVPAG--
>tr|G2NG39|G2NG39_9ACTO Integral membrane sensor signal transduction histidine kinase OX=862751 OS=Streptomyces sp. SirexAA-E. GN=SACTE_5476 PE=4 SV=1
----------VATGLRLCLHALLAGLLML--VAVRAVGDGAPHGTAVAVLAAVTAALYGAGVLAAVQPHTAAAVWLAGLGALWLALLVLSPDALWVAFPL
YFLQLHLLPVRRGLPAVVVTAAAAIVSFLLHGQEVTPGTFIGPLLGAAVAVLGYEALFRESDRRRELIEELVSTRAELAAAERTAGTLAERERLAREIHD
TLAQGLSSIQLLLRAAERTLP-GDAPATVHVRRAREAAQENLAEARRFVRALSPPDLE-HGSLAGALSRLS-ARTSTPLTVQCAVSGTPVE-MPLPYEVT
LLRTAQSALANTVRHADARRAEITLSFMETSVSLDVVDDGRGFDPSALG-SRSG---EGGFGLPAMRARARSLGGTLSVESAPGQGTAVAVTLPAA--
>tr|D5NYS4|D5NYS4_CORAM Putative signal transduction histidine kinase OX=649754 OS=Corynebacterium ammoniagenes DSM 20306. GN=HMPREF0281_01758 PE=4 SV=1
----------EAEIMRNGVHILTATILVV--AILMSVQMSLPLAVLNLLLLSVFAALYFVGSFYLERMNVWKLAWLVALTVVWIADILIASAGIYLLFVL
FFLYLRILGMVWGSIAVIFGTAVSVG--IQFPQGLSFGGVMGPVVSALVTVYAFKSLHEINTERTALIRELVDTRQQLAETERAAGVAGERQRIAHEIHD
TLAQGLSSIQMLLHAANRDLEGNVDKARERIDLARHTAADNLQEARAMIAALQPVALS-QTSLVGALERMADGFAATGLDIAVESDGAVHQ-LPMKLEAV
LLRIAQGAVGNVVKHAHATRARITVTYNDEGVRVDIVDNGEGFDVDAVS-RPAG---LGHIGLAAMKRRAEEVSGEVIIESTPGHGTAVSVSVPLI--
>tr|C8X6Y6|C8X6Y6_NAKMY Histidine kinase OX=479431 OS=Y-104) (Microsphaera multipartita). GN= PE=4 SV=1
----------VFVGLRTGLHVLVAGLALF--VVAQAWSAGRPSAVAITLVAAAFLVVYAAGFVTADRNRIFSRIWVAALSVLWMALIWLTPEAAYLAFPL
FFLYLEVMPGWRGPFTVALATVVAILG-SGWAGGWTAGGILGPIIGAAVAIAGYHSLQREAAEREQLVAELVATRAELAHQERAAGAAQERARLARDIHD
TLAQGLSSIQMLLQAAERADP-TG-PSAGHVRLALATTADNLAEARTLVRELTPAPLA-DAGLVAALRRLAQTQWQRPLAVTIE-ADEALD-LPMATQTA
LLRLAQGAMANVLQHARATRATIGISRRPAAVRLTVRDNGIGFDVDHWP-PAGG---PDSFGLAAARTRVEQLGGTLELTTAPGRGTTVTVELPVT--
>tr|C0VWJ7|C0VWJ7_9CORY Two-component sensory kinase OX=548477 OS=Corynebacterium glucuronolyticum ATCC 51867. GN=HMPREF0294_2189 PE=4 SV=1
----------GFSYITVGIHTITALLLAV--TVATSLSVGLLEFMQVSFLAVTFGAIYYAGNHFFEQLNSQHGLWAFGLTALWILLLPHHLSAVYLVAAL
YFVYLRSFDERISTAAILGATGVVIV--ANVPTGITVGSVVGPLLGGCVTIFVFRRMWRMSAEKEQLIDQLMKTRSQLAQTEHEAGMAAERQRIAHEIHD
TVAQGLSSIQMLLSVAEADKPKE---PLKKIAIAKKSAADNLAEARAMIAALQPAALA-KTNLEGALERIAENIE---VDVNISVEGEDRQ-LPMRTETT
LLRIAQGALGNVVKHSQATAALVTLTYDPDEVRLDVVDNGVGFDPAQVA-RPRG---LGHIGVDAMRERAREVGGTLAIESTPGQGTAISVAVPII--
>tr|G0PS78|G0PS78_STRGR Integral membrane sensor signal transduction histidine kinase OX=649189 OS=Streptomyces griseus XylebKG-1. GN=SACT1_1538 PE=4 SV=1
----------VTAALRLCLHALLTGLLAL--VVVRTASQDASHTAAVVGVAVLMAAVYAAGPLASVQPGNAGAVWLAGLGALWAPLLVLSPDALWVAFPL
YFLQLHILPMRWALPAVVVTAAAAITSFVVHRQAIEPGAFIGPLIGAAVAVLGYDALFRESERRRELIVELVATRADLAEAERTAGTLAERERLAREIHD
TLAQGLSSIQLLLRAAERSLP-EEAPAAAHVRAAREAAQANLAEARSFVRALTPPDLE-HGSPAAALERLC-ARTTGPLTVRFTVSGTPVE-LPTPYGVA
LLRTAQSALANTVRHARAGRAEITLSFMDTSVALDVVDDGQGFDPSGTV-HERG---DGGFGLPAMRARAGSLGGALSVESAPGQGTAVALTLPVP--
>tr|G0HGC8|G0HGC8_CORVD Two-component system sensor kinase OX=858619 OS=(Corynebacterium mooreparkense). GN= PE=4 SV=1
----------IRGALGLAL-----GLLLL-VTVWAAADRKDAAVTLVVVLAVPFAVVAAVGLMRPVESPHYG--WLVVLTLLWIALASQEATASYLALVL
FVLYLLLLPSPWGAVATGVATALAVM-LSVAVAGPSTGAILGPVLAGVAAIMVVRSMSAVSESRGQLIDELVRTRGLLAESERQAGIITERERLAHEIHD
TVAQGLSSIQMLLHAAERDIP-ADSGALDRVHLARSTAARSLRETRAIIAALQPDDLQ-DGSFPQALRRLA-AGSDGLIGVDLEVHADGPD-LPMRVEAG
LLRIAQSAVSNVRQHSGADRARITLTVEPGSVRLDIVDDGCGFDRDAVV-ERAG---EGHIGLSAMAHRARSIGGTLEIESTPDGGTAVVVSVPSE--
>tr|K0JVW1|K0JVW1_SACES Two-component system, sensor histidine kinase OX=1179773 OS=NBRC 15066 / NRRL 15764). GN= PE=4 SV=1
----------TRAALAWCLHLLVVGLIALALTAANAPAIADGTASRTAVVAALLAVVYAVGVVVGVSRSRSARWWLAAVCAVWVALLVLTADAVWVAFPL
YFLQLHLLPRRAGVAAVAVTALAAVTAFAVHQ-GFTPAAVLGPVLGAAVAVWGYQVLYRESERRRRLIEELTATRADLSEAQHAAGVLAERERLAREIHD
TLAQGLSSIQLLLRAAERILP-DREDAARHIAQARRTAVDNLAEARRFVAALSPPALD-GTTLAGALERLC-ATTRSP-TARFHLVGRPVP-LPTAHDVA
LLRIAQSALANTTRHARAGTAEVTLDYRDDEIALEVADDGEGFDPAALA-PDPA---AGGFGLAAMAARVRSLGGTLTVESAPGRGTTLAARLPIP--
>tr|L1MAE8|L1MAE8_9CORY ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein OX=1035195 OS=Corynebacterium durum F0235. GN=HMPREF9997_02383 PE=4 SV=1
----------GENGMRQGIHILTGLLLVV--IVASALRNSLMQMGLVALVAATFGGVYALGARRRDAMSLMSQLWLLALTLLWVVLLPIHSIAVYLVFPL
YFLYLQVMPDFRGVIAVVGATAISIF--SRLPVGITAGAILGPVVAAVVSVYAFRALWTVSQERQELIEELLETRSQLAATERAAGIAAERQRIAHEIHD
TLAQGLSSIQMLLYVAEQDISEEAEVPLKKIRLAKSTAADNLGEARAMIAALQPAALS-KTSLEGALQRAASGIH---TEIVIVVDGDERQ-LPMRTEAS
LLRIAQGALGNVAKHAQAERCHVTLSYGEKEVRLDIVDDGVGFNPELIE-RPVG---LGHIGLDAMRQRAAEQGGEVNVESSPGNGTAVSVALPVE--
>tr|C6R7D8|C6R7D8_9CORY Two-component system, sensory transduction histidine kinase OX=553206 OS=Corynebacterium tuberculostearicum SK141. GN=CORTU0001_2112 PE=4 SV=1
-----------ADALRTGIHILTAGLLVV--GIFTSARMPLSQAIINLLLLVGFAAVYFAGSVYGEYWARVRYLWLCILSVLWVADLFVAPAAIYLVFAM
FFLYLTVLDMAAGIACVIVASIITVV--VQIPQGLTFGGVMGPAVSALVTIYAFRTLSRMN-------KELIETRSQLAATERDAGMVAERQRIAHEIHD
TLAQGLSSIQMLLHSADRDLDKDAGKARERIELARRTAADNLHEARAMIAALQPPTLN-EASLEAALTRMAENFGATGIHVEVESEGEVQQ-LPMKVEAA
LLRIAQGAVGNVVKHAEASRARITVTYEGDEVRLDVVDNGKGFDPAAVS-TPAG---LGHIGLAAIRRRAQELGGEVIIESAPGEGTAVSVSMPLG--
>tr|C0WG74|C0WG74_9CORY Two-component sensory kinase OX=525260 OS=Corynebacterium accolens ATCC 49725. GN=HMPREF0276_0460 PE=4 SV=1
-----------SDALRTGIHFLTAVLLVV--GIFTSVKMPLSQSLINLLLLVGFAAVYFAGSIYAEQWPRMHYLWISILTVLWGADLFVAPAAIYLVFVM
YFLYLTVLDMAAGILCVIGATVLTIV--VQIPGGLTFGGVMGPAVSALVTVYAFRTLSRMN-------RELIETRTQLAATERDAGMVAERQRIAHEIHD
TLAQGLSSIQMLLHSADRDLDKDIPAARRRIELARRAAADNLHEARAMIAALQPPTLT-ETSLEAALTRMAENFAATAFQVEVDSEGAEQQ-LPMKIEAA
LLRIAQGAVGNIVKHAGASRARITVTYETDEVRVDVVDNGQGFEPATVS-APAG---LGHIGLSAMRRRAQELGGDVVIESAPGEGTAVSVSMPLD--
>tr|K1V481|K1V481_9ACTO Signal transduction histidine kinase OX=1195457 OS=Streptomyces sp. SM8. GN= PE=4 SV=1
-------------------------------MAVGRALVDGGGQGWAVVVAGVFGAVYAAGPVVGVRGSRGAVVWLVAVGVLWAGLLGLTADAMWLAFPL
FFVQLHLLAGRAGPWAVALTTGVAVCSYAAHQGGFTAAAAIGPVIGAAVAVRGYQALYRESEQRRRLIEELTRARADLAAAQHTAGVLAERERLAREIHD
TLAQGLSSIQLLLRAAQRSLG-GEEGAGRYVEQARQAAADNLAEARRFVAALAPQNLE-GTTLAGALERLC-ATTSATLTVRFHLAHDPGP-LPAAYEVA
LLRIAQAALGNTVRHAGARTAEVTLSGLGDAVALDVVDDGRGFDPAALA-PDPD---RGGFGIPAMRARARALGGTLTIESRPGGGTAVAAQLPVP--
>tr|G0HAR5|G0HAR5_CORVD Two-component system sensor kinase OX=858619 OS=(Corynebacterium mooreparkense). GN= PE=4 SV=1
----------LLETLRLALHLVFAALLVVSLVQFFASDA--ADASPARRLTALLAVVYLAGTVAGQTTHRFALPWLAVVLGLWLVLVVLSADAVWLLFPL
VFVVLSLTGSVAGALAVVGCWVVAAGVPLITQRSGVGGVL-GPAIGVLFAGLAYLRLTREVEYHRQVAEQLVATRDRLLAAENQAGRLAERERLSREIHD
TLAQGFNSVLLLSRAARTAIDGRTGDATDQLSVITATAHDNLIQTRVLVAEESTAAVT-ATPLAASLRRLTGDARARALGASTTIDAEATA-LPAPVAEA
LLRVAQEAVTNAVDHAGASRIRVTLGVWDTEATLDVFDDGCGFDPASVQRTE-----LGGYGIAGMRDRVTALGGEFTVDSTVGTATVVAVRVPTG--
>tr|A0K2K3|A0K2K3_ARTS2 Periplasmic sensor signal transduction histidine kinase OX=290399 OS=Arthrobacter sp. (strain FB24). GN= PE=4 SV=1
----------ILRLLRVSLHVGFAVLLLVATARVLVSGP--GLTGW--LLALLLATVYVIGTVLEKRHS-TDTWWLGAVSVLWLVLIWSSADFVWLAFPL
FFLQLHILPR-RVALPVIAASTVLVVVAWFHPALELPMAL-GPVFGAAFAVITYRALYLEAENQRLAAEELRRTRGELARSQHDAGTLTERARLAREIHD
TLAQGFSSIVLMGRSAEKALDGDTATARERLRTMQETASANLAEARNFVRGLQSPAL--EQSLAGSLRRLCEKTEAAARGAGFRCRGTPVE-LSNPYSTT
LLRAAQASLANVWVHAKASTAVVTLSFMGTEVAMDIYDDGVGFRPAPEGSGGSPRKDGSGYGLRSLRERVTALAGTLDIESAG--GTVVAIRLPLV--
>tr|G4QPG0|G4QPG0_CORPS Two-component system histidine kinase ChrS OX=935697 OS=Corynebacterium pseudotuberculosis CIP 52.97. GN= PE=4 SV=1
----------ILTLLRVSLHLMFAALLGFGIIRFTLSPD--SESPWKLCLALGLGAFYMFGTAWENRFA-RGDWWMLVITLMWAILMGASGSFTWLMFPL
VLIALNLLPGIRGILSVLLLLGIATIIPWLAEDWVLGQLL-GPIIGACFSVAIYYVLNQDAMHYRQVAAELLAAQRDLAASEHQSGRLEERERLSREIHD
TVAQGLSSIVLLSRAAHRHCEGDLENVQRQLAIIEKQAGESLAEARRFVRDLAAPAL--GESLPIALQGVIDGVKQSALGCPLDVHGDMETSLPEPVTRT
ALRVAQEGLNNVVKHAHANKAVVTLGIWEDEVSIDVVDNGLGFNAARLTTATD--QSEGGFGLGGLKKRIATVDGSLVIESDE--GTALVCRIPLT--
>tr|G7HWV0|G7HWV0_9CORY Putative signal transduction histidine kinase OX=1110505 OS=Corynebacterium casei UCMA 3821. GN=CCAS_05480 PE=4 SV=1
----------VLDGLRVGLHIMFAFLLGFGVLRSLV------DAPLNPAFSVLMAGLYMAGTVYERHRA-KQGYWLAGIIVLWLLLLTHSQDFLWLEFPL
VLLTLHIAALVPALITALGLWLVAAFVPWLHETWGVAAAV-GPLIGTVFAVAIYRALHAEVQHHRRVAQQLRATQEELAASEHQAGRLEERERLSREIHD
TVAQGLSSIVLLARAGKNSEEG------KQLDTIEEVAVENLAEARRFVRDLASPDV--QASLPQALRATVNRMRGEALGESTEFRGASEESIPQPIAAA
VLRCAQEGLSNVVKHAQAEMAVVTLGVFGDAVTIDVVDNGVGMSDAQLKSQQ----T-GSFGLAGLRRRIEGVGGTMDIESHG--GTALAARLPLT--
>tr|I7L895|I7L895_9ACTN Uncharacterized protein OX=883169 OS=Turicella otitidis ATCC 51513. GN= PE=4 SV=1
----------ILSTLRGAVHAVLAALLVVAALSFLAENP--AGGRTALGLAGVLGAAYLLGVLAAPLGPWAGIAWLAALVALWAALVVVSDSFVWLLFPL
VFVVLSQLPPAAGAAALAAMWALAALVPY--RDNGVAGVV-GPAFGVLVAAGAYRALSAEAQQFRRLAEELREARGRLLEAENAAGRLAERQRLSAEIHD
TLAQGFNSIVLLSRAARGQLAEQAAKLRSHVAAIEDTASDNLAEARRLVAG---RAAP-ARPLSEALRELAAKARERDLGRDVLIEPEAGP-LPDSAAAA
LYRIAAEALANALRHGEPSRVRLTLNHFGDEVALDVFDDGRGFDPDAVETTA-----EHGFGIAGMRRRAAAAGGELTVDSEP--GTVVAATIPLR--
>tr|F1YFG6|F1YFG6_9ACTO Histidine kinase OX=644548 OS=Gordonia neofelifaecis NRRL B-59395. GN=SCNU_02837 PE=4 SV=1
----------MSSDHRTGGHVLFVTLLAIGLRQAL---A--GQAPIAVGVAVVVGTVYLFGAITVTRRKSVRAGWVLALTAGWVALVLLSPGFVWVAFVL
AMLCWRFLTIPLSVVAEIVIAATSVSATLLHPDIGIGGII-GPVIGICTAAAVYGRVSRMVDERDDLIGDLIATRERLAQQEREAGTLAERERLGDEIHD
GTGQALASIVLLLRAATSP--DTPEDQRGQIETALDTAQTALAESRRFLRGLHGSDLE-PDGLTDALSRAAAQQSVAGLPTVFEVHGTPQE-LPAQARHA
LLRVAQESLTNVAKHAEARRAVITLTHLPGEIYLDVSDDGRGFDPGAVDADEH---SGSGRGLHTMRRRMSEAGGTVTVESRP--GAVVHARIRLD--
>tr|D9VR49|D9VR49_9ACTO Histidine autokinase OX=253839 OS=Streptomyces sp. C. GN=SSNG_03847 PE=4 SV=1
----------LATVMHTAFFLLLGASVARFLLRH--PGE--PRTPWVISLGIALALLYVLGPAVGVTQALRRRLWLGLVVTTWVVLVVLAPSFAWCAVPL
FFTALRTLPPRAAVALVAVLTVFVVAAQMKLSTAFDPNLLLAPPAIAALATAVFVHMERQARAQRALIDDLIRTRRELAATERREGTLAERQRLSMEIHD
TLAQHLSSQQMLLQAADRTWDSDPATARAHVRTANGIAARGLAEARRLVHDLAPPELDNGAGLAEALRAL---DAGPGVEVRFHLEGVPAP-LPDRTESA
LLRIAQGALANVREHAHAHTAALTLSFLGDQVVLDIADDGAGFTATT--SDP-----GRGHGLPAMRARVRQLGGTLTIESTP--GTVLSASIPLE--
>tr|H6RB46|H6RB46_NOCCG Histidine autokinase OX=1127134 OS=Nocardia cyriacigeorgica (strain GUH-2). GN= PE=4 SV=1
----------LAIVMHATFYVLLGASLARFLIRH--PGS--PQSGWVLALSGVLALLYVAGAPRGRR----GLVWFALLVACWAVLVVLAPSFAWCAVPL
LYTGFRILSVRVAVVLVVVLTGLVVLTQVRLAGWGDPNLLLAPPAVAAVTTALFVQMRRQTVRQAALIDDLLRTRQELAATERREGTLAERQRLAIEIHD
TLAQGLSSQRMLLQAADRIWDSDAERARSHVRTAATIAEQNLAEARRFVHDLAPADLAATGSLDAALRTLAERENSDELAVRCVIDGTPVR-LPGRIEAT
MLRIAQGALANIREHAAARTATLTLTYLDDQLLLDIADDGRGFDPATAGSGR-----DRGYGLPAIRARLQQLGGTLTIESAP--GAVLSAAIPLE--
>tr|C6R798|C6R798_9CORY Two-component system histidine kinase ChrS OX=553206 OS=Corynebacterium tuberculostearicum SK141. GN=CORTU0001_0394 PE=4 SV=1
----------VFKGQKLGLHAMFAFLLVFGVTRAYV------DDRLDARLAIALAVVYAAQ------------WWLGGLCLLWLGLMVHAQDFMWLEFPL
IFVFLRALPTVPGLVSIAVLWAAAAFIPWLHEGWSIAAAV-GPLIGTAFAATVQRRLQAEAAHHRDIAKQLRETQAELAASEHQAGRLEERERLSREIHD
TVAQGLSSILLLSRAARGTDDATKE---EQLAVIEDVASENLAEARRFVRELAGPD----ERLETQLTSLLSQMRVKALGEGPTFEGSGK--VPGRIKEV
IVRAAQEGLNNVIKHAHASRAVVTLGLFEDAVTLDVVDNGRGLSASPRPSGR----D-NGFGLSGLRGRVEGVGGTMSLES-G--GTALAVRIPLK--
>tr|E8N752|E8N752_MICTS Signal transduction histidine kinase OX=979556 OS=Microbacterium testaceum (strain StLB037). GN= PE=4 SV=1
----------MFAGLRIGLHALFAGLLVLVVVRVLVTGA--GAAP--IALTVALGLVYLAGAARRGRSG-AGIAWVLVLTAVWAALVWLVPEAAYLVFPL
FFLYLHVLPRVAGPLAVVATTALTIAAFAVHGGLTVGGVV-GPVVGAGVALLIYAALERRAAEREELMAELLATRDRLAAAEREQGTLAERGRLAREIHD
TVAQGLSSIQMLLYAAERADATGP--GIAHIRLARQTAADGLAETRRFIRELAPPSLT--QGLGPALERLARSWGEHAGVDVEVDVPDEVE-LPMDAQTA
LLRIAQGALANVAQHAAATRVRVVLTAAGHAVRLTVADDGRGFDPDAPDARGG---GTDSFGLRAMRERVDQLDGTIEVTSTP--GTTVAVTLPSG--
>tr|J1RGC4|J1RGC4_9NOCA Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein OX=745408 OS=Rhodococcus sp. JVH1. GN= PE=4 SV=1
----------MFAGLQLGLHALIAALTAVVILRAVLPDA--PQAPAIVVLSVAFLAVYAAGATRRLR----GTWWLAALTALWVALMVLAPDAAYLAFGL
FFLYLHLLPRRWGVLAVAAATVVAVVGTGMHRGWSVAGVV-GPVIGACVAVAIYRALYREAVERDRLIDELTRTRAELAEQERAAGSLAERERLAREIHD
TVAQDLSSIQMLLHAAERAAPDHP--ARDRIRLARETAADSLAETRQLIGDLTPAVLD-GQSLADALARICTQARSDTFDTIAVVEGEPVR-LPMPVEAA
LVRIAQGAVSNVVRHAHSSRMAVTLTYYEDAVRLDVVDDGIGFDAELLDREP-----SKAFGLNSIRRRVELLDGSMSVESEP--GTAVAVSFPLE--
>tr|E3BC14|E3BC14_9MICO ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein OX=188626 OS=Dermacoccus sp. Ellin185. GN=HMPREF0321_0934 PE=4 SV=1
------------IIMQAAMHVLFVVLLV-GVIRALAGDASPA---VIAAT----GLVVERRAH--------TGVWI------TLAWCLT-PDFAWVAFAL
YFLVLHVAIRPIA-AL-PLVLVAS-VAVS-RP-GRNVGTVIGPIMGMIVALGIYAQLRAENTRRRELVTQ---TQETLALAQHRAGVLAERERLAHDIHD
TLAQGFSSIVLLS---R--AAH---EMVRLLEQIESTAAQGLADSREVVHALTPSD-V-D-PLSGALERLTARLTE-GIRADTC--G-PRP-LPAPVDVA
LLRIAQSALANVRTHSKAQRVGVTLS-RLDEVGLEVIDDGVGFT--VER-APL--GG-SGFGLRAMRERLDALGGHLEIESQPGEGAALIAT-P-S--
>tr|K4R0V6|K4R0V6_9ACTO Integral membrane sensor signal transduction histidine kinase OX=1214101 OS=Streptomyces davawensis JCM 4913. GN=BN159_5517 PE=4 SV=1
------------ARLAAVMHATFFLLLG-SMARYIQRHGGER---WVIAL----GVLYVMGRP--------PRLWL------VAVWVVL-PSFAWVAVPL
FYVALRHLPPGAA-AL-GVLTVFV-IVLQ-LA-RFDLDLVVGPAAVAGFATAVLR---RQAARQRALIDD---TRRELAATERREGTLAERQRLAMEIHD
TLAQGLSSQQMLL---E--WES---KARAHVRTAESVAEHNLTEARRFVHDLAPAD-A-R-GLGEALRTLAAR----GEALTVL--G-APE-LPDRVQSA
LLRIAQGALANVREHSGAASAALTLT-LDDQAVLDVADDGHGFD--LAA-PS------GGHGLPAIRARVRQLGGTLTVESAPGEGTVLSAA-P-E--
>tr|E3FAD9|E3FAD9_CORP9 Two-component system sensor kinase protein OX=889513 OS=Corynebacterium pseudotuberculosis (strain I19). GN= PE=4 SV=1
------------A-----MNILTTVLLIVSVGGVVRLDTR--SAMIAVALSAFFALIY--L--IVLRQYT-KL-WQILLLAALTLVWVLMPVSVYMVFPL
FFLYLRVLPDIRGIIAVIGAALIAIF---SQMPDLTLGAVMGPLVSALVVIAIFEAIWKGARERDLLIRELISTRSQLAETERAAGVAAERQRIAHEIHD
TLAQGLSSIQMLLRVSEQSEA-EQAVPLKRMELARTTAADNLSEVRAMIAALQPAALS-KTSLEGALHRVAEQIVSPEISIL--VEGVERQ-LPMRTEAA
LLRIGQGALGNVAKHSQATRCQVTLTYADDEVRLDVVDNGQGFDPERPA-G------LGHIGINAMRQRAEEQGGTLEVESAPGDGTAVSVALPIR--
>tr|Q8NLK6|Q8NLK6_CORGL Two-component system, sensory transduction histidine kinases OX=196627 OS=LMG 3730 / NCIMB 10025). GN= PE=4 SV=1
------------S-----IHILTASLLVVGLGASARL------TLPMFALSCVLLFVW--F--LYFYGST-KR-VDLLGLFVLTLVWIFMPVSIYLLFPL
FFLYLQVMPDVRGIIAILGATAIAIA---SQYSGLTFGGVMGPVVSAIVTVAIFRTLWRVNNEKQELIDQLIETRSQLAVTERNAGIAAERQRIAHEIHD
TVAQGLSSIQMLLHVSEQEEK-PKEAIVKKMRLARQTASDNLSEARAMIAALQPAALS-KTSLEAALHRVTEPLLGINFVIS--VDGDVRQ-LPMKTEAT
LLRIAQGAIGNVAKHSEAKNCHVTLTYEDTEVRLDVVDDGVGFEPSTPA-G------LGHIGLTALQQRAMELHGEVIVESAYGQGTAVSAALPVE--
>tr|E6SEF2|E6SEF2_INTC7 Integral membrane sensor signal transduction histidine kinase OX=710696 OS=NBRC 12989 / 7 KIP). GN= PE=4 SV=1
------------TALLLGQHVLFAVLLL-----AWGRAAGEP---VVAAA----ALEHRSART--------ALRLL----ALLLAWFAS-PDFAWLAFPL
FFAVLRLLPSAWA-PL-GLMVLAV-FWWA-EV----LATVVGPTVGALVSIGMYQMLLHENAVRQELVDE---THESLAESRRQAGALDERARLSRDIHD
TLAQGFSSIILLA------QPG---ALRTALGAIDQQASQSLTEARAVIADLTPET-S-G-DLPAALERLVTSVSR-GIRATFM--G-ARP-LPRTHEVA
LLRLAQGALANVTAHSGATRAVVSLS-GDDGVRLDVVDDGVGFD--MRE-RED---G-TGYGLRSMRERMALLGGQLTVESARGAGTAIAAH-P-G--
>tr|G4CZK8|G4CZK8_9ACTO Two component system sensor kinase OX=997355 OS=Propionibacterium avidum ATCC 25577. GN=HMPREF9153_1880 PE=4 SV=1
------------VGMQIGIQVLFAGLVIFTVVMALVLSPP--HLWRILTWEILLILVHLMTTHVMDRTRR-DR-WRPVLVTVMVAVSILLPYAAYLTIPL
SFVYLDHLAPLHACIAVLVGAVAIVLG-VGLTSGWSVGGVVGPVAGAAVAVVVLKAMQTQAAELERLNVDLLAVQERLAASQREAGVLEERARLAREIHD
TVAQSLSSIGLLLSAVERTAP-AHP-AIEQIQLAHRTSSEALSETRGLIAELAPPTVA-DQGLPAVLKRLGATTWSLGLHVN--VDPDTSD-LSMEIQTV
LLRLCQGAMSNVVRHARARHATIRISRDESHVHLRVTDDGVGMDLDAPV-R------DGAFGLHAIRQRVDELSGEVSLTSEPGEGTIIDVDLPVH--
>tr|L7LAW0|L7LAW0_9ACTO Putative two-component histidine kinase OX=1121927 OS=Gordonia hirsuta DSM 44140 = NBRC 16056. GN=GOHSU_17_00050 PE=4 SV=1
------------MGLRLGLFVLVGVLALIVLLRALLLGES--HPLWVGALTALFLMILAARPFQNLSLSQ--RLWLGLLSAVWLVLALSGAAAAYVSFGL
IVLLMTELPVVWALVSVVLLTATSIGVGF-LHPGGLAAMVIGSILGGVVGVVIFRVLIEETDRRQLLIADLHHTRAELAEQERAAGEMAERQRLAREIHD
TVAQGLSSIQMLLHAAESEGL-LPG-AREPVRLAREVAAAGLADTRRLISALAPADLT-GRSLIDALGRVCARAPARPQVRL--AVGDPVR-LPMPIESA
LVRLTQGALSNVARHSGAVCAVVTLSYSPGKVRLDIVDDGKGFPVGADA-E------APRFGLDSMRARVEELAGEWDLQSEPGY-TAVSVTFPVT--
>tr|C8NJA6|C8NJA6_COREF Probable sensor histidine kinase OX=196164 OS=11189 / NBRC 100395). GN=HMPREF0290_0081 PE=4 SV=1
------------S-----IHILTATLLVVGLGASARL------PLPMFAVSCVLLFVW--F--LYFWGSS-RR-VTFLALFVLTLVWVLMPVSIYIVFPL
FFLFLQVMPDVRGIIAIVGATSVAIV---SQYPGLTLGGVMGPSVAALVTIAIFRTLWRVNNEKQELIDQLLETRSQLAETERNAGIAEERQRIAHEIHD
TVAQGLSSIQMLLHVAEQEDD-AAGSPLHKIRLARTTASDNLSEARAMIAALQPAALS-KTSLEGALHRVTAPLLGINFVIN--VDGDERQ-LPMKTEAT
LLRIAQGAIGNVAKHSEAKNCHVTLTYEMDQVRLDVVDDGVGFEPEQPA-G------LGHIGLNAMRQRAQELNGEVIVESAHGQGTAVSVALPIE--
>tr|F9NTF0|F9NTF0_PROAA Histidine kinase OX=1051006 OS=Propionibacterium acnes SK182B-JCVI. GN=HMPREF1162_0318 PE=4 SV=1
------------VGMPIGIQVLFAGLVIFTIVMALVLSPP--HLGRILMWSVLLAVIYLMGTHIMDRSRR-EA-WRPILVAAMVIVSVVLPYAAYLTIPL
SFAYVDHLAPFQACVAVVVEAVAIVLG-VGLTRGWSVGGVVGPVAGAAVAVVVLKAMQAQAVELERLNEDLLAVQKRLAASQRQAGVLEERARLAREIHD
TVAQSLSSIGLLLSAVERTLP-DHL-AAEQIRLAHRASSEALAETRGLIAELAPPAVV-DQGLPAVLERLGATSWSIGLHVD--VDPDTSD-LPMEIQTA
LLRLSQGAMSNVVRHAHAQHATIRILRDDDYVHLQVTDDGIGMDPDASF-G------EGSFGLQAIRQRVDELAGEVSLTSKPGEGTIVDVILPIP--
>tr|D0L9S9|D0L9S9_GORB4 Histidine kinase OX=526226 OS=10667) (Rhodococcus bronchialis). GN= PE=4 SV=1
------------TALQWSLHVLAVVLAGVVALRALIADSG--GGVAAAALALAWAITYVVGAVAIAGKTPLHPGWAAALTVAWLACLCVSAEAVYLAFVL
FFVYLHLLGMRRGTLAVCAATVVAVVG-FAAHNGWSVAALIGPVLGAGVAVVIYRGLYAEVVARQQLIDELVATRENLAAEQRAVGRARERERLSREIHD
TVAQSLSSIQMLLFAAERSVA-DAP-VPAELPVAREAAAEALTETRRLIAELSPAPLA-GRSLVSAIRRIADGAGTHIDTDV--VVGNPEV-LPMALESV
MVRIAQGAVSNVVRHSGATSLRVTITYAPDRVHLDIVDNGRGFDVE----D------AQAFGLATIRRRAEELDGQLDITSEPGN-TSVAVAFPIS--
>tr|H8G9Y8|H8G9Y8_9PSEU Signal transduction histidine kinase OX=882081 OS=Saccharomonospora azurea NA-128. GN=SacazDRAFT_00593 PE=4 SV=1
------------TALAWCLHLLVIGLLV-AAGRAVADDQPDE---LVVVA----GLMSAVGPR--------AAWWL------GAVWLVL-PDAVWVAFPL
YFLQLHLLPRRAG-GA-AATAVAA-ITAA-HT-SFSLAMVIGPALGAAVAVAVYQALYRESEQRRRLIEE---TRADLAAAQHTAGVLAERERLAREIHD
TIAQGLSSIQLLL---E--LPG---DAARHVDAARQAAVDNIAEARRFVAALTPPT-E-G-TLAGALERLCTTTST-RLTAHFL--G-PTP-LATAHEVA
LLRIAQSALANTVRHAEATSAEVTLS-LGDHVALDVVDDGRGFD--LPA-PDP--ES-GGFGLAAMRARAQALGGTLTVESAPGHGTTLAAQ-P-T--
>tr|G8VIF4|G8VIF4_PROAA Histidine kinase OX=1114967 OS=Propionibacterium acnes TypeIA2 P.acn17. GN=TIA2EST22_05335 PE=4 SV=1
------------VGMQVGIQVLFAGLVIFTLVMALVLSPP--RLGRILGWAALLIVVYLMGTHVMSRSRR-EM-WRPLLVTVMVVVSILLPYAAYLTIPL
SFVYLDHLPPLQACVAVVVGAVAILLG-VGLTGGWSVGGIVGPVAGAAVAVVVLKAMQAQAAELERLNVDLLAVQKRLADSQRQAGVLEERARLAREIHD
TVAQSLSSIGLLLSAVERTAP-DHP-AIEQIRLAHLASSDALSETRGLIAELAPPTVV-HQGLSAVLERLGATTWSIGLHVD--VDPDTSD-LPMEIQTA
LLRLCQAAMSNVVRHAHARHASIRIVRNPGHVLLRVSDDGVGMDLDAPV-R------DGAFGLQAIRQRVEAASGEVSLTSKPGEGTRVEVDLPCR--
>tr|D6A5J2|D6A5J2_9ACTO Two component system histidine kinase OX=566461 OS=Streptomyces ghanaensis ATCC 14672. GN=SSFG_06940 PE=4 SV=1
------------TALAWCLHLLIIGLLA-AAGRAGTDDRPHG---LIVGV----GLVYAVGPR--------AALWL------GVVWLVL-PDAVWVAFPL
YFLQLHLLPRRAG-AA-AATAAAA-IAAA-HQ-SFSPAMAIGPALGAAVAVAVYQALYRESEHRRRLIEE---TRADLAAAQHTAGVLAERDRLAREIHD
TLAQGFSSIQLLL---E--LPN---NAARYVDQARQAAVDNLAEARRLVAALTPPT-E-G-TLAGALERLCTTTSN-RLTARFL--G-LAP-LATAHEVA
LLRIAQSALANTVRHAEATTAEVTLS-LGDRIALDVVDDGRGFD--LPA-PDP--EA-GGFGLTAMRARVQALGGTLTVASAPGHGTALAVQ-P-T--
>tr|A4AF38|A4AF38_9ACTN Two-component system, sensor protein OX=312284 OS=marine actinobacterium PHSC20C1. GN=A20C1_10169 PE=4 SV=1
------------VGLRTSLHVLFAALTALVVVRAFMVAHP--SSLFVIALSGLLVATYVLGRVFVRSASA-YV-WLLALSLEWLVLVWLIPDAAYLVFPL
FFLYLHVLPRGWGTAAVLVSTVLSIVA-LGLHTGWTVAGVIGPLVGAGVAVVIYQSLAREAAERERLMVQLLETRDQLAKTEHEAGVLAERARLAREIHD
TVAQGLSSIQLLLHAAERA-A-PEA-GLEHVRLARETAAANLADTRRFIRELSPAALV-EQGMGAALRRLADTQWQSEREVR--IRADALD-LPMPIQTA
LLRIAQGAMANVVQHAQATQATISIDRDSAGVRLVVSDNGRGFDPAATG-T------SDSFGLTATRERVEQLGGALSISSKLGQGTTLTVELPRA--
>tr|A3TM13|A3TM13_9MICO Putative two component system histidine kinase OX=313589 OS=Janibacter sp. HTCC2649. GN=JNB_04580 PE=4 SV=1
------------MTLTVVQHILFGVLAA-CVTRSWSTGAPRP---LVVAA----GLRWGARST--------HGWWL------VACWLAL-SENVWLAFSL
WLLIPHFFPVRWA-VI-GVLAV-V-IWWF-ET-GLTVAEALGPAIGALFAFALQHQLVRDAIERQRLVDS---LHDELASSQREAGVLQERGRLSRDIHD
TLAQGFSSIVLLA------VVA---GLTDLLTQIESTASSNLTEAREVVSALAPKT-S-D-GLVQALGRIVDTLSR-GIATELV--G-PLH-LPTANEVA
LLRTAQGALANVRSHSGAGRVVVTLS-LEDRVLLEVVDDGRGFD--VAE-RAGAYSH-GGYGLPSTRARLRELGGDLVLESAPGEGTALSAH-P-G--
>tr|H5U4J5|H5U4J5_9ACTO Putative two-component histidine kinase OX=1089453 OS=Gordonia sputi NBRC 100414. GN=GOSPT_113_00420 PE=4 SV=1
------------AALRWGLHLLAVALTVVVMVRAL-IATP--TDVAAAIVAGVWLAVYFAGGLVVGNRRR--ALWLAVLTAVWLVELALTAEATYLVFVL
FFLYLHLMGRRIGLAAVTLATGVAVVG-YALHNGWSAAAIIGPVLGAGVAVVIYAQLFAEARQRERLIDELVAARADLSDQQQAIGRAEERERLAAEIHD
TVAQSLSSIQLLLHAAEQS-T-GEQ-AASSIMLARKAAGDALTETRRLIAELSPAPLD-GSSLADALRRVAADASGHITVSV--LIGDAQP-LAMPTEAA
LVRVAQGAVSNVVRHSHAGRLHLTLTYTADEVHLDIVDDGTGFASD----A------SEGYGLSTIRRRVDSLGGQVDITSDDGG-TTVAVSFPAV--
>tr|C5BWR7|C5BWR7_BEUC1 Histidine kinase OX=471853 OS=Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432). GN= PE=4 SV=1
------------AWLQAALDVLLVALVG-AVSAYADLEPPRA---LGAGL----G--YVLGRW-------WPHAWT------VATWAVL-PAALWIAFPL
MFLEMHVLGPRRG-LA-ALTTALA-VAAS-FA----VGAVLGPVIGGAVAVTVLEAVVRESQARQALIVD---TRADLARTEHARAVVAERERLAREIHD
TLAQGFSSIELLL---D--LER---GARRHVTTSREAAHANLAESRRFVADLAPPD-A-R-NLVAALERVAARVPE-GPPVDVV--G-PRA-LPAAAEAA
LLRVAQSALANVTQHARAGRARLTIS-LDDGVALDVVDDGLGFD--RAA-DG------GSFGLRAMRSRLAELGGVLTVESAPGEGTALAVH-P-D--
>tr|H5TM72|H5TM72_9ACTO Putative two-component histidine kinase OX=1108044 OS=Gordonia otitidis NBRC 100426. GN=GOOTI_114_00090 PE=4 SV=1
------------AGLRWGLHLLAVALTAVVMARAL-IASP--ADIAAAVVAAVWLAVYFAGGLALGDRRR--AAWLTVLTTVWLVELALTPEATYLVFVL
FFLYLHLLGRRRGSVAVVLATAVAVIG-YAAHSGWSAAAVIGPVLGAGVAVVIYAQLFAEAAQRERLIDELVTARADLEEQQQAVGRAAERERLAAEIHD
TVAQSLSSIQLLLHAAEQA-T-GER-AQVSIALARTAAANALTETRRLIAELSPAPLD-GSSLADALRRVAADAAGHIDTSV--VIGDVEH-LAMPTEAA
LVRIAQGAVSNVVRHSQATALHLTLTYTDDDVHLDIVDDGTGFAPD----T------SEGYGLTTIRRRVADLGGIADVSSDAGG-TTVAVSFPLA--
>tr|H6QZ92|H6QZ92_NOCCG Sensor kinase, two-component system OX=1127134 OS=Nocardia cyriacigeorgica (strain GUH-2). GN= PE=4 SV=1
------------TALRLGLHVLVTALVAVVVIRALLPGAS--YPAAVIGLSVALLAVYFAGAAVGDRRGG--MCWLGVLTVLWLLLVAFSADAIYLAFGL
FFLFLHLLPRPVNYLAVAAATGVAVAG-FGLHRGWSVAGVIGPVLGAAVAVGIYRTLFRESAERERLITELLSTRASLAEQERTAGKLAERERLAQEIHD
TVAQGLSSIQLLLHAAEQAAP-DHP-ALPQIQLARATAAEDLAETRRLIAELTPAALV-GTSLAEALARVCRRAESPLAAQV--VVGTPER-LPMPIEAA
LVRIAQGAVSNVVQHAHASRMRLTLTYAESEVLLDVVDDGAGIAPGDQP-P------PGSFGLAATRRRVEQHGGTMTVESEPGH-TAVTVSFPLP--
>tr|C2CRC5|C2CRC5_CORST Two-component sensory kinase OX=525268 OS=Corynebacterium striatum ATCC 6940. GN=HMPREF0308_1954 PE=4 SV=1
------------G-----IHILTATLLVVAIFTTVRLPLW--QAVINLLLLTAFAVVY-----FAGSVYV-EQ-WPRYLLVILTVVWMADPAAIYLVFAL
FFLYLYVLDLYAGVVCVVIATIISVT---VQIPGLTFGGVMGPAVSALVTVAIFRALSLMN-------RELIETRSQLAESERESGMIAERQRIAHEIHD
TLAQGLSSIQMLLHAADR----DVPRAKERIELARRTAADNLHEARAMIAALQPPALA-EASLEGALTRMAENFAATDVEVD--SEGDVLK-LPMKVEAA
LLRIAQGAVGNVVKHSEATRARITVTYAPGEVRVDVVDNGHGFDVTKPA-G------LGHIGLSAMRRRAEELGGEVIIESTPGSGTAVSVSMPLD--
>tr|K7S664|K7S664_PROA4 Signal transduction histidine kinase OX=1171373 OS=6432 / NBRC 12425 / NCIMB 8070). GN=PACID_23530 PE=4 SV=1
------------TGLRFGLHALLVGLAVFAVARAFLVSSP--TRIATSAVGVAFVVVYLLGAWAARSGGS-TGVWIVVLTLLWAVLVWLGPDAAYLVFPL
FFLYLHVLPGAGGVTAIVVSTGFAIGA-LGLHQGFSVGGVIGPLIGAGVALLIYRALRREARERERLLEELIRTRHQLADAEREQGALAERARLAREIHD
TVAQSLSSIQMLLRAAQAT-T-PEP-GAGYLELARETAAESLADTRQIIRELTPSRL--GDGLAAALRRLGQDQSRRGAAVS--VDQE-LD-LPMAVQTA
LLRIAQGALSNVILHAGAARIGVELTGAEDRVDLVVRDDGHGFDVSASH-E------AGSFGLQAMRERVEQFGGTFVVDSGPGRGTTVTARLPLG--
>tr|D9XWA1|D9XWA1_9ACTO Sensor kinase, two-component system OX=467200 OS=Streptomyces griseoflavus Tu4000. GN=SSRG_01600 PE=4 SV=1
-------------------------MLA-ALVRASAEHAPDG---AVTGA----AGVYAVGPR--------AACWL------GAVWLLL-PDGVWLAFPL
YFLQLHLLSRRGG-LA-AATAVAA-ITAA-HR-EFSPAVAIGPALGAAVAVAVYQALYRESERRRRLIEE---TRADLAAAQHTAGVLAERERLAREIHD
TLAQGLSSIQLLL---E--LPG---AAGAHVVQARRAAVDNLAEARRFVAALTPPA-D-G-TLAGALERLCATTGA-RVAVTFR--G-PRA-LPTALEVA
LLRVAQSALSNTVRHSGAATGEVTLA-LEDGVRLDVVDDGAGFD--LPA-PDP--AA-GGFGIAAMRARARSLGGTLAVESSPGRGTAVSAW-P-S--
>tr|H6N3K4|H6N3K4_GORPV Putative histidine kinase OX=1112204 OS=Gordonia polyisoprenivorans (strain DSM 44266 / VH2). GN= PE=4 SV=1
------------TALRLALHAMAAVLAVVVAVRAVGSEGT--TSVTAVTLAALWLAIYASGMVLVRSSPA--GWWLAALSLVWLGCLSVSADAVYLVFVM
FFLYLHLAGMRWGTACVAVSTAAAVVG-FGLHGGWSVAAAIGPVLGAAVAVVIYRRLFDEVRSRQRLIDELLATRAELAAEQQEVGRARERERLAGEIHD
TVSQSLSSIQMLIYAAERR-A-GGH-SP-ELHTARTAAADALGETRRLIDELTPAPLD-GRSLSAALQRVTDDAGGHLSTRL--VVGEPFG-LPMPVEAA
LVRVAQSAIGNVVQHARARVLRVTLTYSSDEVHLDIVDDGAGFDAD----A------ASGFGLTTMRRRVRELGGDLDVVSEPGH-TSVAVGFRVE--
>tr|G7GJ59|G7GJ59_9ACTO Putative two-component histidine kinase OX=1075090 OS=Gordonia amarae NBRC 15530. GN=GOAMR_03_01440 PE=4 SV=1
------------TGLRSGLHALLVGLAVFAVVRAFVVSSP--VAVWTLLVGAGFVGVYLSGAWAARTGIP-FTGWVIALTVLWAVLTWLRPEGAYLVFPL
FFLYLHVLRGRHGVVAVVAATAFAIVA-LGLHLGFSVGGVVGPLVGAGVALLIYRALIREAHEREQLLAELIATRSRLAETEREQGALAERARLARDIHD
TVAQGLSSIQMLLRAAERD-T-PEP-GAGYLRLARETAAGSLADTRQIIGELTPSRL--DDGLPAALRRLGDEQSRRAATIE--VSAD-VD-LPMSTQTA
LLRIAQGALSNAVRHADATHITVDLSAASETVMLTVRDDGCGFDTTDAH-E------AGSFGLRAMSERIGQLDGTLTITSAPGRGTPVAAHLPTS--
>tr|K0EZY6|K0EZY6_9NOCA Two-component histidine kinase OX=1133849 OS=Nocardia brasiliensis ATCC 700358. GN=O3I_037930 PE=4 SV=1
------------TALRYGLHVLVTALAVVVAVRALLPGAA--HPLPVVALTALFLLTYFAGSVVNGRPGG--ILWLGALTVWWLGLVVLAPDAGYLAFGL
FFLYLHLLPRPWSLVAVAASTAIAVLG-FGAHRGWSVAGVIGPIFGAAVAVGIYQALFRESAQRQRLIDELLSTRATLAERERTAGKLAERERLAKEIHD
TVAQGLSSIQLLLHAAEQSAP-EHP-ALQQIVLARETAAENLAETRRLIAELAPAALE-GQSLAQALERICLRANTPRTAQL--VVGTPER-LPMPIEAA
LVRIAQGAVANVVRHADAARLRLTLTYADAQVLLDVVDDGVGIAADARP-P------SGSFGLAAMRSRVEQQGGTMAVESEPGH-TAVTVAFPLW--
>tr|G7HXU3|G7HXU3_9CORY Signal transduction histidine kinase OX=1110505 OS=Corynebacterium casei UCMA 3821. GN=CCAS_07460 PE=4 SV=1
------------G-----IHILTATILVVAILMSVRMSLT--AAAFNLVFLSVFAALY-----FVGSFYM-DR-MSYLVLTALTVVWIVDPAGIYLLFVL
FFFYLRVLGMVWGVIAVIFGTAVSVG---IQFPGLTFGGVMGPVVSALVTVAIFDRLHAINMERAALIRELMETRQQLAETERAAGVAGERQRIAHEIHD
TLAQGLSSIQMLLHAANRGAG-NVDKARERIDLARHTAADNLQEARAMIAALQPVALS-QTSLVGALERMSEGFAAADIEVE--SDGTVHQ-LPMKLEAV
LLRIAQGAVGNVAKHANATRARITVTYEDKGVRVDVVDNGDGFDLARPA-G------LGHIGLAAMKRRAEEVGGEVVIESTPGHGTAVSVSVPLT--
>tr|D5NWP5|D5NWP5_CORAM Putative signal transduction histidine kinase OX=649754 OS=Corynebacterium ammoniagenes DSM 20306. GN=HMPREF0281_01005 PE=4 SV=1
---------------------MFAFLLGFGVLRSLFDAPL--NYAPLLSVALALLYVAVVERRAQRRGAI-SVGWLA-----IIVLWLVLQDFLWLEFPL
VFLTLHILALVPALVTVVAAAFVPLW---LHPESWALAAAIGPLIGTALAVAIYRALHAEVQHHRAVARQLRTTQEELAASEHQAGRLEERERLSREIHD
TVAQGLSSIVLLARAAKSS---ED--PQTQLATIESVAVDNLAEARRFVRDLASPDVQ-ESALRGTLARMRERGAALGEKTE--FRGDTAT-IPQPIAAA
AIRCTQEGLSNVVKHAHASTAVVTLSVFADAVTIDVVDDGVGMDTTSP---------EGSFGLAGLDRRIAALGGSLSIESQPEGGTALAARLPLT--
>tr|H5U402|H5U402_9ACTO Putative two-component histidine kinase OX=1089453 OS=Gordonia sputi NBRC 100414. GN=GOSPT_103_00370 PE=4 SV=1
----------------EVWTLRVLYLVALVVAQLVPASSTQHLVSASALIALMVFTEIWTRVNI-GPMWRRVGIFAVT-TTLIAVAIAATPIAGIASWAG
YMLYASLFTGLPMVLTISVSC--VLMTATQRYGASVLAWILNFVIGVA----VTEARETSVIRRNQLTEDLLAEQSELLEQARLVGIRDERSRLARELHD
TVAQGFVAVVTQLESVDEA--ELSDATRDRVDNAKMLAREGLGEARRAVNALRPLTLD-AQPLPTAVQDQLTAFAKRNITAVLRVDGDAHD-LGGS-DDT
VLRILQESLANIAKHAGAQRVVVTLTYLDDELLLDIRDDGDGFDVDAVRRSA-----HSGFGLTGMVERAQLLRGTVVVESDPGAGCVVSVSIPT---
>tr|E4N2R1|E4N2R1_KITSK Putative two-component system sensor kinase OX=452652 OS=A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae). GN= PE=4 SV=1
----------------RLANLAVHGLFFTLLAVLLARAAADGLGPGGWATAGALAAVYAAGGAI-RESRTLGACWLLAVAALWIGLTLEHPEFSYLAFPL
YFVCLHALPPRLGLPAVVALTAAVIAAQTTTPGGLTTAKVIGPLAGAALTAYGYAALYRENRARQRLIDDLVRTRDELAASQREAGRLAERQRLAREIHD
TLAQGLAGIVLLAREAAGTDS--TATAAPLLDEIERTASANLAEARRFVHALTPPALD-GTTLADALRRLAD--G---ADAAFHRDGEPYP-LPVEAEVA
LLRLTQEALANAVRHAAAAHIAVTLGYLDDAVTLDVYDDGTGFDPAT-APAP-----DS-FGLHGMHERIAALGGTLTVESAPGEGTAVAAVLPL---
>tr|I0V6M9|I0V6M9_9PSEU Signal transduction histidine kinase OX=882086 OS=Saccharomonospora xinjiangensis XJ-54. GN=SacxiDRAFT_3586 PE=4 SV=1
----------------PLILLAVATLIGVTDPGQTGSQRWEIIAYTLLTTVVVVLTDTGTPPGW-RTPWRNTTAFVAL-LSCASVLTLVDPVFTVFTIAA
FFRALTLRPKPAMVAGLAVTS--ALIHSLPAGGTWPFLYLTIVAVQTAGGFVLSERFIAQSEENRALVAELRTAHRQLLVQARESGVLDERQRISREIHD
TLAQGFAGIITQLTAARRS--GAPAESRRRTDLAIALARENLQQARRAVHALTPGELD-GVGLSEALAAVTARWADRAIDAEFSTTGTAVA-LHPEIETT
LLRVTQEALANVAKHARATRTVVTLSYLADQVALDIRDDGVGFSAAPSAGAR-----TGGYGLPGMLRRVQRIAGRFVVESEPGGGTAVCATVPA---
>tr|K6VIB7|K6VIB7_9MICO Putative two-component histidine kinase OX=1184609 OS=Kineosphaera limosa NBRC 100340. GN=KILIM_030_00100 PE=4 SV=1
----------------PYALLAVALAAAFGLVNALPAMPAWTMPWFVALAVLAAAVRAWGAAPA-GPARARLAFWLGL--GVTLALVLLNPAFGLYAFIF
YPDGTRLLHGVQARLGLGAVA--VVCSLAQTGGTPLFVGLF-LLVNLVSMALFDRQRQRVSDELTQANARLRAEQEQLLEQARDAGVTQERARLAREIHD
TIAQDLVAIIAQLSAASQAAAGIDDELARRLDLAERTAREALAEARRSVRALSSPRLD-SDDLPAAVQRLLDAWAQTTATARLAVRGPAVP-VEP--DGV
ALRVIQEALANAARHAGARAVDVILTYETDALEVEIADTGAGFDLAA----T-----ATGHGLPGMRQRVEQAGGALRLVSIPGQGTHVSARLPR---
>tr|H5TGD6|H5TGD6_9ACTO Putative two-component histidine kinase OX=1108044 OS=Gordonia otitidis NBRC 100426. GN=GOOTI_012_00020 PE=4 SV=1
----------------EVWTLRALYVVSLVVAQLVPASFTRHLVSASVMLALIVFTEFWIRVDI-SAMWRRVAIVVVN-TALIATAIAATPIAGIASWAG
YMLYASLFTGFPMLLSISVSC--VLMTATQRYGASILAWILNVVIGVA----VIEARETSVIRRNHLTEELLAEQSELVEQARLAGIRDERSRLARELHD
TVAQGFVAVVTQLESVDEN--ELSRATHDRLENAKALAREGLGEARRAVNALRPVTLD-AQSLPTAVREQLSAFSQRTVSAVLRVDGDARE-LAGS-DDS
VLRILQESLANIARHSGARHVVVTLTYLDDMLLLDIRDDGCGFDVGAVQRSM-----HGGFGLTGMCERAELLGGSVVVESEPRSGCVVSVSIPI---
>tr|C7QHJ0|C7QHJ0_CATAD Histidine kinase OX=479433 OS=102108 / JCM 14897). GN= PE=4 SV=1
----------------PYAGLAVSLTLALIIGPRTGVYYTVVLGGSAAAALWVR-RGRALLDAP-NPPVLRATVYYAVLLALLATLILTSPLFGFFGFTG
YLHAM-VLPGRTKLFGIAGTA--GAMATTQMGGAGVYLYLVLVAVNLLT---LTVTGAAEEEHRR----ELAEAHAQLVAQAREAGVLDERQRLAGEIHD
TIAQGLTGIVRQLEVVERF--DDVERRKHHLTLARELARESLAEARRSVQALRPGPLA-VAQLPEALAELAASWSRTAIEARVEVSGEAVA-LSPEVEVA
LFRAAQEALANAGKYSGAGRVGVTVSYTSDVVVLDVVDDGAGFDPEERRGAN-----GTGYGLSAMRSRLRQVGGTLTIESEPGDGTAISAAVPL---
>tr|H8G6A1|H8G6A1_9PSEU Signal transduction histidine kinase OX=882081 OS=Saccharomonospora azurea NA-128. GN=SacazDRAFT_01312 PE=4 SV=1
----------------PLLLLGVAAVVSVANPQHSPEQRWQVIAYTLVSAAVIVFTDTAPPPWW-RTRWWRVGAFLAL-LGCASVLTLLDPVFTVFTIAA
FFRALILRPKSVMLAGLAVTS--ALIHSLPGGGTWPYTYLVIVVVQTASGVLLSERLVAQSEERRALVAELRAAHQQLLVQARESGMLDERQRLSREIHD
TLAQGLAGIITQLTAARQA--GTAEEAARRVDTALALARENLHQARRAVHALTPGELD-GSGLCDALAAVTTRWAERSIAAEFSTSGTVRA-LHPEIEAT
LLRVTQEALANVAKHARASRTVVTVTYLPDQVALDIRDDGVGFDDDPVTRAW-----SNGYGIPGMRHRVQRIAGHFVVESERGAGTAISATVPA---
>tr|B1VT00|B1VT00_STRGG Putative two-component system sensor kinase OX=455632 OS=Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350). GN= PE=4 SV=1
----------------PPALLAVALVLAGATAAFIGMSDWWALGALAAAALVLQLWWDRTARAR-PGPHAAGATYYALRSALGFGLAWINPFCAFYAAVG
CFDVERLVPRRWIPLGLLATA--VTIAGAQIGGGSMTRWVFYGLLVAVVFLTVRHDAEKEEHRTRERVETIRELHDQLLLQAREAGIAEERRRLAAEIHD
TVAQDLTGVISQLQVVTDS--REPDTVRVHAERALQLARHSLGEARRAVVNLAPVALA-EDDLPEALRKTVARWSERTVQAEFTLTGTAEP-QHDEVRAT
LLRIAAEALSNAARHAKATRVGVTLTYLGQEVVLDVRDDGHGFDPSAPERGT-----GSGFGLAGMRARAERLAGELTVESEPGLGTVVSACVPS---
>tr|F4FFK8|F4FFK8_VERMA Histidine kinase OX=263358 OS=Verrucosispora maris (strain AB-18-032). GN= PE=4 SV=1
----------------PYGGLAVGTLLALLTPAPRGLPIWLTLTVVVAAGAWVA-WFINLHPGW-QSRRTRMAVYYAGLLTFAAVLVVASPWYGYFAWIG
YVHAFPVLSWRWRIGGVAVTA--VLLATAQGGGSGSQLWLVLVLFNVLAVIWFNIVAEREDAKRKRLVAELAAAHAQLVTQAREAGVLDERQRMAREIHD
TLAQGLTGIITQLEAAEQT--RDSGDWRRHVDNALALARESLTEARRSVRAIRPEPLE-AARLPDALTELGGRWSARHVRAEVNTTGTPRP-LHPEVEVT
LLRAAQEALANVARHAAASRVGLTLSYMSDVVTLDVRDDGTGFDAEA----P-----DGGYGLTAMRQRVTEVGGRLDVESEPGGGTAISASVPA---
>tr|H5XR40|H5XR40_9PSEU Signal transduction histidine kinase OX=882082 OS=Saccharomonospora cyanea NA-134. GN=SaccyDRAFT_3450 PE=4 SV=1
----------------PLLMLGVAAVLSVANPQQNPEQRWQTTAYVLASAAVVVFTDTAALPRW-RTPWWRAAAFVAL-LSCASVLTLVDPVFTVFTIAA
FFRALTLRPKVLMVTGLAVTS--ALIHSLPAGGSWPHVYLIIVVVQTAGGLLLSERFVAQSEERRALVAELRSAHQQLLAQARESGVLDERQRLSREIHD
TLAQGLTGIITQLTAARQT--GTPAERERRIDTATALARESLHQARRAVHALTPDELD-GTGLREALAAVTARWADRAIDAEFSATGTVRA-LHPEIEAT
LLRVTQEALANVAKHARASRTVVTLSYLADQVALDVRDDGVGFNPDRLGRAW-----ASGYGLPGMRRRVQRIAGDFVVESEPGGGTAVCATVPA---
>tr|D9V5E0|D9V5E0_9ACTO Two-component system sensor kinase OX=591158 OS=Streptomyces sp. AA4. GN=SSMG_00619 PE=4 SV=1
----------------GILALAVCTIIAAGQPHGDPAQWRTTLLLAAASGLWLLVLIPVFPRRT-RKPWLAIGFFLVLLAGATVLTSRLDP-FTAFASVG
YPIAFVLFPTRWSIFAAAATA---VVPLLAKG-QPSPPWITAVSI---PILYVAWFVGAENEQRRRTNEKLAQTHAQLLTQARQAGVLDERQRMAREIHD
TVAQGLTGIVTQLQAADRA--TEAADRQRHLAHVHTLAKDSLTEARRAVQALRPEPLA-DSHLPEALAGLANRVSDTSTKVTADVEGDARP-LLPELEVT
LYRVAQEALANAEKHARANRIGITLTYTSDLIMLDIRDDGRGFAPGDRGDG-------TGFGLEAMRQRVQRVAGSLTIESARGEGTVVHAECPA---
>tr|E8WAM4|E8WAM4_STRFA Integral membrane sensor signal transduction histidine kinase OX=591167 OS=Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD). GN= PE=4 SV=1
----------------PYTLLGIAVLMAALSSGIIGMSETYVTGLLVLAALVLQLWWGRREPGV-PPKSRPAQGYYVLRTLIAFALCWFNPFFSVYAIVG
YFDVGHLLPPRFVRPGLLCTA--VIMAGAQCGGASPVNWAAFGALFLLLTLLFGNLSAREEERTRRQTATISELHAQLLLQAREAGIADERRRLAAEIHD
TIAQGLTGIITQLQAVTST--RDPAVARAHLGRAAGLARHSLGEARRSVRDLVPAALE-EDDLPGALGRTVTDWEERTVRADFTVTGTVEP-LHGEVGST
LLRIAEESLSNAARHAGASRAGVTLSYMGDEITLDVRDDGCGFDPAASHDG--------GFGLGGMRARAERIAGTVEIETEPGQGTAVSARVPL---
>tr|H6MV32|H6MV32_GORPV Putative histidine kinase OX=1112204 OS=Gordonia polyisoprenivorans (strain DSM 44266 / VH2). GN= PE=4 SV=1
----------------EVWGLRVLTLAGLVVAQLVPATHLHHVIGAVLMLTLMAFTEFWIRIDI-TPMWRRFTVFGIT-TALLAAAIAVTPMAGIASWAG
YMLYASLFTGPPMLLCVAGSC--VLMTATQRNGASILCWALNVVIGLA----VIDARESTLLRRRELTDELIAEQQELLEQARRSGVHDERARLARELHD
TVAQGFVAVVTQLESIDED--DLASSVRDRVENAKALAREGLGEARRAVNALQPLPLA-ARSLATALQEQLALFSRRHIAATLRVDGSPRP-LVG--DDA
LLRITQESLANVARHSGATQVVTTLTYLDDTLLLDIRDNGRGFTPDETRRCP-----DGGFGLTAMAERAALINGTLEIEAEPGAGCVISVALPF---
>tr|A0JS65|A0JS65_ARTS2 Periplasmic sensor signal transduction histidine kinase OX=290399 OS=Arthrobacter sp. (strain FB24). GN= PE=4 SV=1
----------------AVVHLGFAVLLVASAVRYVMRHSPAD-NLWVLALAVAVCSLYAVIAVL-SQRRRPWAVWMFVLVALWAVLVIAAPSFAWCSFAL
FFLCRTAFSGWVAYLAGGATAAATAVGLFRLSGGSDIAMLLGPL---AMLTLIYDRIEQDAAEQRHLHAEVSLAQGRLAASERRAGTIEERERVSREIHD
TVTQGLASSLLLLEAANRSWP--AEAAREDVLTASGMLRRNLADTRSLVHELASPGLD-TAPLPEALLQAAS----QYPGVRLLVTGEPRP-VPADVRHA
LLRVVQSAAANTKLHAGAANATVTLGFLPGAVTLDVYDDGAGFDPHSLAPPS-----DAGYGLRAMRQRVEQLGGVFSVESTPGEGTIVAAQLPT---
>tr|L7KHW4|L7KHW4_9ACTO Putative two-component histidine kinase OX=1220583 OS=Gordonia aichiensis NBRC 108223. GN=GOACH_03_05550 PE=4 SV=1
----------------AGLRWGLHLLAVALTAVVMARALIATIAAAVV--AAVWLAVYFAGGLA-LGDRRRALVWLTVLTTVWLAELALTPEATYLVFVL
FFLYLHLLGRRRGSVAVVLATAVAVIGYAAHSG-WSAAAVIGPILGAGVISAGYAQLFAEAAQRERLIDELVTARADLDEQQQAVGRAAERERLAAEIHD
TVAQSLSSIQLLLHAAEQATG--ER-AQASIALARTAAAEALTETRRLIAELSPAPLD-GSSLADALRRVAA-DASGHIDTSVVIDGDVEP-LAMPTEAA
LVRIAQGAVSNVVRHSQATTLHLTLTYTDDDVHLDIVDDGTGF-----APDA-----SEGYGLTTIRRRVADLGGIADVSSDAG-GTTVAVSFPL---
>tr|C3JP70|C3JP70_RHOER Sensor kinase, two-component system OX=596309 OS=Rhodococcus erythropolis SK121. GN=RHOER0001_5536 PE=4 SV=1
----------------AGLQLGLHVLVMALAGVVFLRALIDELTATIIALAVIFVAVYLFGVAK-RLRGNAARWWLAVLTLVWIATMAVSADAAYLAFGL
FFLYLHILRRPWSLLAVTAATAVAVVGTGLHRG-WTIAGAVGPIIGAAAIGLGYQALYREAAERGRLIDELMNTREELASTSRDAGKFAERERLAAEIHD
TVAQGLSSIQMLLHAAERADP--DSPAIRQISLARETAADSLAETRQLIAELTPAALD-GQSLADALRRICE-RASSPLEARSVVEGEAVR-LPMPLEAT
LVRIAQGAVSNVLRHADATRMAVTLTYSDDTVSLDVVDNGRGFDVAVLERGP-----AESFGLNAIRRRVELQGGTFSIESEPG-HTAVAVTFPL---
>tr|D6AYJ6|D6AYJ6_9ACTO Two component system histidine kinase OX=457425 OS=Streptomyces albus J1074. GN=SSHG_03441 PE=4 SV=1
----------------------MHLLVAALLVMAVGRALVDGQGWAVVVAGVAFGAVYAAGPVV-RGSRRGAVVWLVAVGVLWAGLLGLTADAMWLAFPL
FFVQLHLLAGRAGPWAVALTTGVAVCSYAAHQGGFTAAAAIGPVIGAAAVVRGYQALYRESEQRRRLIEELTRARADLAAAQHTAGVLAERERLAREIHD
TLAQGLSSIQLLLRAAQRSLG--EEGAGRYVEQARQAAADNLAEARRFVAALAPQDLE-GTTLAGALERLCATTSATALTVRFHLAHDPGP-LPAAYEVA
LLRIAQAALGNTVRHAGARTAEVTLSGLGDAVALDVVDDGRGFDPAA-LPAP-----DPGFGIPAMRARTRALGGTLTIESRPGGGTAVAAQLPL---
>tr|F8JWR7|F8JWR7_STREN Putative two-component system sensor kinase OX=1003195 OS=14057 / NRRL 8057). GN= PE=4 SV=1
----------------RWMRGALHGTFAVLLAVALGRAAA-GATPVVLAPGVLLGAVYAAGVRR-SPSRGRAWAWLAVVTALWAALLALDADFGYLAFPL
FFLYLHLLPARWSLPCVAAATAVVVVTQSAGPGGLTAAKVIGPLAGAGLTAYGYAALYRESRERQRLIDDLMTTRDELAAAQHEAGRLAERQRLAREIHD
TLAQGLSSIVLLTRAAEGALD--PDAAGGHIRQAGRTAAENLAEARRFVRALTPPDLQ-GASLPEALRRVAA--RHPGARVEVRVDGEPYP-LPVRAEVA
LVRLTQEALANVARHAGAGRATVTLGFLDGQVTLDVYDDGVGFDPGR-GAGR-----DS-FGLHGMRERIGELGGTLTVESAPGEGTAVAATLPV---
>tr|G4IYW0|G4IYW0_9PSEU Putative signal transduction histidine kinase OX=882084 OS=Saccharomonospora paurometabolica YIM 90007. GN=SacpaDRAFT_1185 PE=4 SV=1
--------SPAVRGLTAAVHLVAAVLVTTVVVRAVTGTAELAPFAGPTAVTVAVAWAYAVGVLVPAVTRATGRAWLAVSGVLWLVLLVLTADAVWLAFPL
FFAQLSLLPTRWALPVVVLTTGAAIAGFGWHHHELTAATVLGPALGALVTVLGYRALYRESERRRRLLVTLGRTRDELASAEHRAGMLAERERMAREIHD
TVAQGLSSIQLLLRAAERALDDRPPPGPADPVADLETAATNLAEARRFVRDRRPAALD-GTSLPEALRGLCARTTGESPVVRCHVSGAAVP-LSSATEAA
LWRVAQSALANTVAHARADRADVTLSYMDTEVALDVVDDGIGFDDPTTDPTTGPGTRWGGFGLRAMRARVEELGGSLVVESATGRGTAVAATVPAR--
>tr|E9UTC3|E9UTC3_9ACTO Two-component system sensor kinase TcsS3 OX=408672 OS=Nocardioidaceae bacterium Broad-1. GN=NBCG_01999 PE=4 SV=1
--------RSTVRAMEVGQHVIAVVLTAIGVSRAVGDGVAL-PVAVASGVA-ILGW-HTAGAVLPSRTRSRRLLWLVGFAAIWTAAVVVSAEFVWLAFLL
WLLAGHLLPLRWGLAFSALILVVVIVAPVLDRGTTSYADVFGPVIGGIFISRGYLQLLRDAAERERLVTSLAELQDELVLAQRHSGAVAERTRISRDIHD
TIAQALSSIRLLTHAGGSRTTDEDASRTFAQVEAL--AGDSLADVRRIVAALAPAELE-DAALASALRRMLDRAHDEALVAELHVDDTLPL-LRTEVEVA
LLRTAQSALSNVRLHAGATRVVVTLTDDQDSVRMDISDDGAGFDVAAWEQDAGAGS----YGLRFMRARLRELGGGLDVESTPGEGTAVSAHLPIH--
>tr|C0ZSD5|C0ZSD5_RHOE4 Probable two-component histidine kinase OX=234621 OS=Rhodococcus erythropolis (strain PR4 / NBRC 100887). GN= PE=4 SV=1
--------------LAYAIHASFFVLLSTSGVRYVTVHGTSGRFGVVLVLAVVLALLYAVMATVSSRDVVRQRLWPVLST--WAALVWLAPSFAWCAFPV
LFLCIRLYPSKIAYPLVGILGVLAGIAFYRVTGRAELVTLLGPLCTAALVAAAYGQMERDARERLRLLRQVAEAQSALADTERAAGVAAERERLAREIHD
TVTQGLASALLRLEAAEQTWNTTGSPSRADVDAAAENIRTSLMQSRDLVHDLAPAK-----GGTGDFDALVVAAARQFPTVRIRTVGEAVI-LPSDVAHA
IVRVVSSASSNIARHARAETAGVTITYLDDSVSVDIFDDGVGF-------DPGKLARYGGYGLRAMRSRIAQLGGSFTVESAPGDGTVVAAQFPLE--
>tr|B1VGA7|B1VGA7_CORU7 Two-component system sensor kinase OX=504474 OS=Corynebacterium urealyticum (strain ATCC 43042 / DSM 7109). GN= PE=4 SV=1
------------HGLWLGLQVLMIGLLILVAWRAT--HP---M-TWV---G--LGVFWVLYCSQRTRWG--APTWFALLVGAWAVMSVGQLEGAFVVFPM
FFLAVYVFSPRISAAVVAALTLGVVTMLVGH-IGWNIGAVTGPIIGAAVAWTLGVG-------FQLLLDALVAAREEALASSRKAGEADERMRLAGDIHD
TVAQGLSSIHMLLTAVENQLA-GP-NPLTQVRLARATAAENLAETRRIIAALQPAPLE-GAALPVALARLASSTPLGE-KLSFETDGAPRP-LPDEVEEG
LLRCAQSLVSNVVRHSGADRAKLSLTFHPGDVILDVVDNGAGFDPSDAID-------RRSLGLSGVYRRVEALGGEMTIESAPGEGTGISITVP----
>tr|F8DY97|F8DY97_CORRG Two-component system sensor histidine kinase OX=662755 OS=Corynebacterium resistens (strain DSM 45100 / JCM 12819 / GTC 2026). GN= PE=4 SV=1
------------TALGHSLHLLVFILLAVTVAADGM-SW---Q-VGAFAI------AYASGRILPQRP-----LWMALVLVCWVLIFIHAESAVYIVFPL
FFVALGAFRARVSVPLVILMTALAIYGIARH-LGWSPGGVIGPIIGALVAIALGLG-------FRML-RVEAKAREKE---SHRAGEMQERARIAGDIHD
TVAQGLSSINMLLHSIEGQISSDP-ELVRQIHLAQTTAQDNLLETRRIIAALQPSPMM-GADLPVALARVTSSSPLGQ-AVVFDVDGEPRN-VDAAVEQE
LVRIAQSLVSNVARHAQATRARVTLTYQPEEIVLDVVDNGEGFDPAAGTE-------LAATGLPGVLRRVKSIRGAMALETAPGAGCGVAVRVP----
>tr|Q8NP16|Q8NP16_CORGL Two-component system, sensory transduction histidine kinases OX=196627 OS=LMG 3730 / NCIMB 10025). GN= PE=4 SV=1
------------RVLIWGLHLLIAVLLVLVCWRAS--HW---G-VWVLAFG--YGVVYVAGVVPNSPFN--HPAWFLVLSLLWASLIWDGPEPAYLVFPM
FFLAVLITTPLKSAIIIAILTAIAVVTLAMH-LGFSVGVVTGPILGALVAWVMGTC-------FQLLLKELVDARASAIRASKSAGEQAERARIAGEIHD
TVAQGLSSIQMLLHAAEKRVD-DP-QALSHIRLARQTTADNLAETRQIIAALQPTPLI-GADLPVALARLSSTTPMGQ-NITFEVDGSPRV-LPDAMEAE
IVRIAQTLLGNVVRHAQADSAKMTLTYQDDQILLDVIDNGQGFDVAEVIR-------KKSIGLPTAQRRAEGLGGTIIIESTIGSGTGISARFP----
>tr|C8RTR9|C8RTR9_CORJE Two component system sensor kinase TcsS3 OX=525262 OS=Corynebacterium jeikeium ATCC 43734. GN= PE=4 SV=1
------------AYLSMGLHLLMALLMAVVIVRDGW-SW---N-AVALCF------IYVMGLWLRPTW-----LWLTLVIATWACLLLVAPSAVFMAFAL
FFLCVGVLPLWPAIVCNAVVTTLSVY---------QGGEALGPIVAAVVATVVGVG-------FKEL-RDEASAREAA---SRHAGEMGERTRLAGEIHD
TIAQGLSSIHMILQAVEKRVE-DP-EVLEDLRLARTTAEDNLAETRRIIAALQPGPLV-GGDLPIALARVSSGTPLGE-ALSFEVEGEPYD-LDEKVEQE
LTRIAQSLVSNVVKHSEATRARVTLTYQSDLLSLDVVDNGRGMDEEERMS-------LSPVGLAGVRRRANLIGATMHVESSPGAGCGVSIQVP----
>tr|C0WH52|C0WH52_9CORY Histidine kinase OX=525260 OS=Corynebacterium accolens ATCC 49725. GN=HMPREF0276_0788 PE=4 SV=1
---------------------MFTFLLLFGVARAYI-D------------DRILLAIGLAAVYAAARWI--PTLWLTGLCLLWLGLMVHAQDFMWLEFPL
IFVFLRALPKWPGLISITALAAAAFIPAWLHPDGWSIAAAIGPLIGTTFAAGVFYI-------QRRLAKQLQETQAELAASEHQAGRLEERERLSRDIHD
TVAQGLSSILLLSRAARTTDDLTK-N--EQLAVIEDTAGENLAEARRFVRELAGPD-L-ETQLDSILSQMRRREALGE-DTTFDLSGNG-S-VPSDIKQV
VVRAAQEGLNNVIKHAHASRAVVTLGLFEDAVTLDVVDNGHGVI--EPPR-------HG-SGFQGLSQRVESVGGSLSLES--GDGTALAIRIP----
>tr|D2AUR1|D2AUR1_STRRD Histidine kinase OX=479432 OS=NI 9100). GN= PE=4 SV=1
------------RTLRAGLHGVFYVLLAIGLTRVSG-S------------WALLGAVYTAGLTLGRRRT--AAVWLAAVVLVWAALGALTTDFVWLAFPL
FFLCMHLLPPRAGVPAVIAVTAVTVGTLAVHGPALNPAQVVGPAIGAMAAVLMVAG-------YTALIDELTRTRAELAETQHEAGVLAERQRLAREIHD
TLAQGLSSIVLLLRAAPP----DP-S--GYVEEARHAAEDNLAEARRFVHALTPPG-L-DGSLEEALRRLCSR----E-GAAFQLDGEP-T-LPRRAEIA
LLRIAQGGLANVSRHAEAARAALTLTYMEDEVAMDIVDDGRGFD--PLTR-------SG-LGF--IRDRAAELGGAVTVES--GLGTALAVTLP----
>tr|K0JS42|K0JS42_SACES Putative histidine kinase OX=1179773 OS=NBRC 15066 / NRRL 15764). GN= PE=4 SV=1
-----------AVWLHRAMHAGFYVLLAASAARYLAYHGADP---VVLGAALCLGALYPAGV--------RWTRALPAVLGVWLVLVWLAPSFGWCAIPL
FFQCLRQLRPRLAVPLAGVLTLAVVLAQIRLADAVEPSLVLGPVGVAVITGAVFFD-------RRRLI--------------HEAGVLAERQRLGREIHD
TLAQGLSSITLLLELGD-------------TRRAADVAKENLAEARRFVRDLSPL---QGRSLEDALRGLCDRV-----EVH----GEPYP-LTVPTEVA
LLRVAQGALANVREHAEAHTVVVTLSYLGDAVTLDVCDDGRGFDPRAVTPGEG-----RGFGLASIRSRVAELGGTLSVESAPGEGTALGVTVP----
>tr|G6HJI6|G6HJI6_9ACTO Integral membrane sensor signal transduction histidine kinase OX=298655 OS=Frankia sp. CN3. GN=FrCN3DRAFT_6318 PE=4 SV=1
----------APAGLGVLYRIIPYVGLVVSALLLVPLQAGWSHVDLGLSAVAAA--WMVWFRTAWVSRRRLMTGYLVVLLALIAVLVVRSPWFGFFAFTG
YLESTALLVGWWRLAGAAVTALIAATSQV---GGVPTVVVIFNVGVAGTMTWFAVVANEQREARGRAIAELGDAHAQLVVQAREAGILDERARLAREIHD
TLAQGLTGIITQLQAAE-----QAGARGRHISTALRLARESLTEARRSVQALRPAELA-EAALPDALADVAARWTQANVPVEVSATGLVVA-LHPEVEAT
VLRVVQESLANVAKHAAANRVGLTLSYMSDVVTVDIRDDGVGFDTDEAGPGQA----EGGFGLAAMRQRVARLAGGFSVESEPGAGTAVSAALPAI--
>tr|D3F982|D3F982_CONWI Integral membrane sensor signal transduction histidine kinase OX=469383 OS=ID131577). GN= PE=4 SV=1
----------EHREERL-LDVLPYGGLAIGALLTLVFPDAARALGWMLALVAVAVVWLTLLRT-RPARQPAGAVFYAGLAALMAALVLVSPLFGFFAFAG
YGFIHA-LPDRWKVLGVAATAAVAGTAQI---GGFPLGLMLANFLIAGTIMFFSVLTYARRDQRREALRELAETQAQLVEQARDAGVVEERQRMAREIHD
TLAQGLTGIVAQIQAAEQAAE-RPERWRRHLRTAAQLARESLAEARRSVQAVRPEALE-NARLPEAVAEVARRWSSIQVGVEVTTTGHPRP-LPTEVEVT
LLRTAQEALANVAKHARAGRVGVTLSYMEDAVTLDVRDDGVGFAVGAAAGD--------GVGLVAMRQRVEGLGGRLEIESEPGGGTAISASAPTV--
>tr|E3J1M9|E3J1M9_FRASU Integral membrane sensor signal transduction histidine kinase OX=298654 OS=Frankia sp. (strain EuI1c). GN= PE=4 SV=1
----------QERSDRL-ARLLMLPMLAISTLLVITLPAVRTQVEIGVAVVAVAALWSTGLIRYGVPPRSRWLVF-GVHLTLAATLVWLNPWYGVFAFTG
YFLADE-LGGHARRVGFVAVALVSAASQA---AGYPNIMAAFNVVAVLLMVNLTNRVMEQNTERGRMIAELAETHAQLLTQAREAGVAEERGRLAGEIHD
TLAQGLAGILTQLEAARRAHA-DPAEWSRHIELADGLARANLTEARRSVRALRPEQLE-QASLSDALADLARDWSRRTVPAEAVTTGVPVR-APAETEMA
VFRIAQEALANVARHAHATRARVTLSYLDDTLLLDVADDGAGFHPGAGAPP---------FGVTGMRRRAESVAGTLSIESAPGDGTTVNAVFPLT--
>tr|H0BLW8|H0BLW8_9ACTO Two-component system sensor kinase OX=1055352 OS=Streptomyces sp. W007. GN=SPW_6256 PE=4 SV=1
----------EDRWEQF-YRYGPYAVLTLSALVGGVAADMTRIMYVAGVLVVAAYGLQLWWGRATAPGDPAGVTYYVARTVLAFALSWLNPFFAIYAALS
YFDVEPLLPKRFVRAGLLTTAVTLAGSQS---GGLPPVLYIVNATLALFFWHVGMREEEKARIQAETIAELERTHAQLLVQAREAGVDDERRRLAAEIHD
TLAQGLTGIIAQLQVVTSVSDRDPETARLHLERAAALARHSLGEARRSVHNLAPVALE-HDELAGALGKTVAGWAEQHVRADFTVTGTVEP-VHDEIAAT
LLRIAGEALANAGRHSGASRVGVTLSFMDDELTLDVRDDGRGFDPATATPAGR----TGGFGLGGMRARAERIAGAVEVESEPGGGTAVSARVPLV--
>tr|Q9L1F1|Q9L1F1_STRCO Putative two-component system sensor kinase OX=100226 OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). GN= PE=4 SV=1
----------DERWAAF-HRWGPYALLAVGTLVAWSAADMTTGRRASGALIGAAVVLQLWWNRARPGPSPAGTCYYAVRWAIGFALTWLNPLFAFYAVVG
YFGAQYLLPRRLCRAGLFATAVTLAGSQS---GGLPPAILTVNSMLVALFAHFAALEEARSRARVETIAELERTHAQLLVQAREAGVADERRRLAAEIHD
TLAQGLTGIIAQLQVVAAAP--DPALGREHLDRALALARHSLGEARRSVHNLSPVALA-EDGLPDALKKTVTEWGARTVQARFTVTGTAEH-LHDEVAAT
LLRIAQEALSNTARHAAADRVGVTLSYMGDEVTLDIRDDGRGFDPLTARECGP----GGGFGLDGMRARAERIAGSLTVEAEPGHGTAVSARVPLV--
>tr|A0ACH5|A0ACH5_STRAM Putative two-component system sensor kinase OX=278992 OS=Streptomyces ambofaciens ATCC 23877. GN=SAMR0469 PE=4 SV=1
----------PVPEPQL-LRFSPPVLLGVGLVLAAATSSMDGTWAAAGTLAAAALVLQLWWDRVRPGPSAAGALYYALRSVLAFGLAWINPFCAFYAAVG
CFDTERLVPRRWVPLGLLATAATIAGAQI---GGLPPMLVAVNTGIFLTVQQDTEKEEDRARERVETIRELEHTHDQLMLQAREAGIADERRRLAAEIHD
TVAQDLTGVITQLQVVTDTQ--EQGPARVHAERALQLARHSLGEARRAVANLAPVALA-EDDLPGALKKTVVRWSERTVQAEFALTGSDEP-LHEEVQGT
LLRIAAEALSNTARHAKATRVGVTLSYMGEEVVLDVRDDGRGFDPSALPERDT----ASGFGLKGMRARAERLAGELTVESEPGLGTAVSARVPSV--
>tr|F3NG10|F3NG10_9ACTO Two-component system sensor kinase OX=996637 OS=Streptomyces griseoaurantiacus M045. GN=SGM_2074 PE=4 SV=1
----------SRR-TTF-ADWGPYALLGVAVLTAAGSAGMTRGLYAAAGLVAAALVLEVTGTRVRPERGRTGAFLYFLRWAIAFVLTWLNPFCAFYAVTG
YYTVGRQLPRRLMLPGVCLTAVTMAGSEI---GGMPPVVLGVNIGMVSLFTRFAEQEQARVTTQAETIAELERTHAQLLVQAREAGIADERRRLAAEIHD
TLAQGLTGIIAQLQVVTAAP--DTATARVHVERAAALARHSLGEARRSVHNLAPVALA-ADGLPEALRKTVAEWGERNTRADFTLTGTAEH-LHDEVSAT
LLRIAQEALSNAARHARAGRVGVTLSFMGDEVSLDIRDDGTGFAPAAVPARTR----GGGFGLEGMRARAERIAGSVAVESEPGQGTAVSARVPLV--
>tr|D1C419|D1C419_SPHTD Histidine kinase OX=479434 OS=Sphaerobacter thermophilus (strain DSM 20745 / S 6022). GN= PE=4 SV=1
-----------ERWER-IHGVFYFSLALGLILSLLNGPS----LDRAALLAALTAALAAWYTVMWSCDDGHILVFFLGEAVMLGTLAWLDASFLVMSFAI
FVQLFAFIPPTWATAGVIALTLILFTDAAL-DG----ALLVFSVIFTIISIFFFAAITRQSQERKRLIDELMATRAALAERERQAGVIEERQRLAREIHD
TLAQGFTSIVMHLEAAEPHIPAEATALRRHVEQARATARDSLNDARRLVWALRPEQLQ-GGSLADALARVAERWSEDTITAHVTVDGTPVP-LPPDVEVT
LFRITQEALANVRKHAQAGRVDITLSYLDDEVLLDVQDDGVGFATPGSVN--------GGFGLTGMRERLRLLGGSLMIESAPGEGTSITVALPLA--
>tr|D5ZW15|D5ZW15_9ACTO Two-component system sensor kinase OX=566461 OS=Streptomyces ghanaensis ATCC 14672. GN=SSFG_02237 PE=4 SV=1
----------DDRWAVF-DRWGPYGLLALSTLTAWTAADMSTGRRACGVLIVAAVVLELRWNRVRPGPSAAGARHYALRWAVGFALTWANPLFAFYAVIG
YFSTERLLTRRLRKAGLFATAVTLAGSQS---GGLPPALLAANTVLVLLFSHFADLEEARGRARLETIAELERTHAQLLVQAREAGVADERRRLAAEIHD
TLAQGLTGIIAQLQVVANTA--DPALAREHVDRATALARHSLGEARRSVHNLAPAALA-DDGLPKALEKTVAEWEERTTPARFTTTGTVEP-LHDEVAAT
LLRIAQEALANTARHARAGRVGVTLSYIGDEVTLDIRDDGRGFDPFRSSGGTP----TGGFGLDGMRARAERVAGSLDVESEPGQGTAVSARVPLV--
>tr|B5HK76|B5HK76_STRPR Two-component system sensor kinase OX=457429 OS=Streptomyces pristinaespiralis ATCC 25486. GN=SSDG_05565 PE=4 SV=1
----------EERWAQF-HRYGPYALLGLATVIAGAGAGMDRAMRAAGVLGVAVLALQVWWGVR-----RAGQIYYALRTVLAFALTWLNPLFSIYAVLG
YFDSGHLLPGRRAYAGLLATAVTMAGSQA---GGLPPGLYVLNASLCLLFARFGVQEAERAKERLATIQALELAHAQLLVQAREAGIADERRRLAAEIHD
TIAQGLAGIITQLQVVTSTT--DPEVAGEHLERACALARHSLGEARRSVQNLAPAALE-HATLPEALKNTVADWSRRTVRARLTVTGTEEP-LHDEVAAT
LLRIAEEALANTARHARAARAGVTLSYMGDEVTLDVRDDGRGFDPLAVAPRSG----SGGFGLDGMRARAERIAGTVAVESEPGQGTAVSARVPLV--
>tr|E3J844|E3J844_FRASU Integral membrane sensor signal transduction histidine kinase OX=298654 OS=Frankia sp. (strain EuI1c). GN= PE=4 SV=1
----------RDPAATL-VAVGPYALLAALTAYTVAQRRAEPGLTVDLALCAATALWMLALVTVWRERPVLMTVFLVGLAAITLVLVVRDPWFGVFTPAG
YVYAFRLLRWPWRLGGICAFAVVAGTAQA---SGIPRAVVVVNVVPMCALAWALERDRLRQEERLRALDEARAAQERLVGQARAAGIRDERERLAREIHD
TLAQGLTGIVAQLRAAEAAGDDDRAGWRRHVTLAAQLSRESLAEARRSVHALRPQELE-CAALGAAIADIAGRWSARHLAVQVTTTGAPGP-LRPEAEAA
LLRAAQEALANVAKHAEASRVGVTLSYLDDEVALDVRDDGRGFDPGATGGPHA----GGGFGLVAMRQRIEALDGTLQIESRPRHGTGISARVP-L--
>tr|C5C2U0|C5C2U0_BEUC1 Histidine kinase OX=471853 OS=Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432). GN= PE=4 SV=1
----------ERRAQAI-VTALPYVLLAVSTVVTLV-QDDLTVVAPVLALTAATVAWVAGFQVRGGSPAPLAAVYYAGLMIAAGGLVWLAPWYGIFAFVG
YVHAYEHLVGGWRHVGAAVTSAIMAVVYL---GGFAEAIVVVSSVLASLCFEFLDVSDRHAAEQRQALAEVHEAHAQLLVQAREAGVLDERQRMAREIHD
TLAQGLAGILTQLQAAEQAAH-EPEAWGRHVTNATDLARESLAEARRTVHAVEPEALA-DARLPEAIGDVARRWSEVNVRADLTTTGDPRP-MHVDVEVT
LLRAAQEALANVAKHARASRVGLTLSYMEDLVTLDVRDDGVGFEPDATRGQHA----DGGFGLAGMRQRVQRLAGRLDVESEPGGGTAISASVPAI--
>tr|G0Q464|G0Q464_STRGR Integral membrane sensor signal transduction histidine kinase OX=649189 OS=Streptomyces griseus XylebKG-1. GN=SACT1_0991 PE=4 SV=1
----------QDTDPRL-LRFSPPALLAVALVLAGATAAMSGAWWALGALAAAALVLQLWWDRTRPGPHAAGATYYALRSALGFGLAWINPFCAFYAAVG
CFDVERLVPRRWIPLGLLATAVTIAGAQI---GGMPPLLVAVNTGVFLTVRHDAEKEEHRTRERVETIRE----HDQLLLQAREAGIAEERRRLAAEIHD
TVAQDLTGVISQLQVVTDSR--EPDTVRVHAERALQLARHSLGEARRAVVNLAPVALA-EDDLPEALRKTVARWSERTVQAEFTLTGTAEP-QHDEVRAT
LLRIAAEALSNAARHAKATRVGVTLTYLGQEVVLDVRDDGHGFDPSAPPEPGT----GSGFGLAGMRARAERLAGELTVESEPGLGTVVSACVPSV--
>tr|F4D0G9|F4D0G9_PSEUX Histidine kinase OX=675635 OS=13855 / CB1190). GN= PE=4 SV=1
----------DKAIDRF-AALA--GLLLGTVLTAFAVSGETATWAWMAALTAVALGWIWFLSVRRARVPVVGGVYMAGLLVLMAALTWLSPFYAFMAIGG
YGHAFCYLHGRWRYVAVAGCAAFSQMGGR---LALPWALLVGNAVVAGGFNWFAAISAQQTERRKRMIAELEETHAQLVAQARQAGVQDERTRMAREIHD
TIAQGLTGIVTQLEAADAA-S-SEADVRDRLRIARGLARESLTEARRSVDALRPEPLE-RAQLPEALADLVDRWSETTVRVRRETTGATRP-LLPDVEVA
LFRVAQEALANVAKHAEATTVGITLSYMDDVVVLDVRDDGRGFDLPDRGAG--------GFGLTAMEQRVHRVSGTLTVESAPGEGTALSASVPAI--
>tr|D7BZM6|D7BZM6_STRBB Putative two-component system sensor kinase OX=749414 OS=Streptomyces bingchenggensis (strain BCW-1). GN= PE=4 SV=1
----------EERWAQF-FRYGPYALLGLATLLGAVAAPMTRRMYAAGALLFVVLALQAWWSRALLAAATAGRVYFALRTALAFALTWLNPFFAIYACLG
YFDAGRLLPPRAARAGLMVSAVAVAGSQS---GGLPPALLVFNATLAIGLNHLGAKETEKAEERAETIAAL---HAQLVLQAREAGVADERRRLAAEIHD
TIAQGLTGIITQLQVVSSTA--DPGLAREHLDRAQALARRSLGEARRSVQNLSPAALE-HDTLPEALKKTVSEWSERTVTARLTVTGTEEP-LHDEVAAT
LLRIAQEALANTGRHARAARAGVTLSYMGDEVTLDIRDDGRGFDPLAAAPRTS----SGGFGLDGMRARAERIAGTVAVESEPGQGTAISARVPLV--
>tr|H1QIE7|H1QIE7_9ACTO Two-component system sensor kinase OX=1120227 OS=Streptomyces coelicoflavus ZG0656. GN= PE=4 SV=1
----------ERQWTAY-HQWGPYGLLAVGTAVAAAASDMTARWYLAGALIAVAVGMQLGWSRTRTGPTPVSVCLYFVRCAVAFVLAWLNPLFGFYAYAG
YFGVDRLLPPRLRKPGLFLTAVTIAGSQS---GGMPPAILTVNVVLLVVFARLAEAEDARGRARVETITELERTHAQLLVQAREAGVADERRRLAAEIHD
TLAQGLTGIIAQLQVVAAAP--DPALGREHLDRALALARHSLGEARRSVHNLSPAALA-EDGLPDALKKTVTEWGERTARARFTVTGTAEH-LHDEVAAT
LLRIAQEALSNTARHAAADRVGVTLSYMGDEVTLDIRDDGRGFDPLTARRRTP----AGGFGLDGMRARAERIAGSLTVEAEPGHGTAVSARVPLV--
>tr|L7FDW8|L7FDW8_9ACTO ATPase/histidine kinase/DNA gyrase B/HSP90 domain protein OX=698760 OS=Streptomyces turgidiscabies Car8. GN=STRTUCAR8_07615 PE=4 SV=1
----------DRRMEQL-HIWGPYGLLGVSAVLAAVSAEDGPAWQAAGVLVGAALALQLWWHGTRADPSRAGTAYYVVRWAIAFLLTWINPFFAFYAATG
YMDADELIPGLWRRLGLFASAVTVAAAQA---GGLPFGLLAVNFGLQALVAHATEQEEQRSRDRAATITELERTHSQLLLQAREAGVADERRRLAAEIHD
TIAQGLTGIIAQLQVVTNTP--DRTLAREHTDRAMKLARHSLGEARRSVQNLAPVALE-SDDLPEALKKTVADWAERTVRAEFTVTGPARQ-LHAELAAT
LLRIAQEALSNTSRHARASRAGVTLTFLGDEVILDIRDDGEGFDPLAVRSRTG----TGGFGLDGMRARAERVAGALTLESEPGHGTAVSAHVPLV--
>tr|D9WQ57|D9WQ57_9ACTO Putative histidine kinase OX=457427 OS=Streptomyces himastatinicus ATCC 53653. GN=SSOG_05731 PE=4 SV=1
----------GTRWFG-LDGFFAVSYLVTATLLLLSGGS----QPLAAVAIGSLTLTVPWYAALLMIEDPRNLVYAIGLVALFSVTTAFNLVGAFALFAV
IPMLIMSLPMGWATTANLCPVLVVAVGEAL--G----VLPLLSIALSVLLGLWIKRVVRQSKERGLLIEELRRSRERVARLSHEAGISAERERLAREIHD
TLAQGLTSIISLVQAAESEVHGAPDQAVNHLSLAGRVAKESLAEARDFVAALTPPALR-GGSLVQAVRRQADGLIAETLEVRCSVMGEEQP-MPMAVSVV
LLRSVQEAIANVRKHAEQARVDVILVFDESGVRLLIRDDGEGF--PDGTQ--------EGYGLRGMQARMEEIDGMASITSSPGRGTTVEVKVPAT--
>tr|I0HEX5|I0HEX5_ACTM4 Putative two-component system sensor kinase OX=512565 OS=/ JCM 3121 / NCIMB 12654 / NBRC 102363 / 431). GN= PE=4 SV=1
----------AQEGTSMTLTWLPYATLAVSVLLVIAAGDAVVELRLILLAVAGTAVWIAFWVTSWNERRVLMVVFLLGMLGWFALLVWMSPLFGFFTWTG
YLFIGYALDGLWRLPAVLPVAAIAALSQV---GGVPTFAVLINVLIAGVMFYVEIQTEKNSIRRAQMIEELAEAHAQLLVQAREAGMLDERQRMAGEIHD
VLAQGLTGIVTQLEAAEA----DPVSRPHHLTSAKRLARESLTEARRSVQALRPQQLD-GVALPDALRDVVRGWSERTVRADLVTTGPPRR-LLPEIEAT
LLRTAQEGLANVARHAGAGRVGLTLSYMEDVVTLDVRDDGAGFDPAQPCVANA----EGGFGLRAMRERLARIAGSLEVESEPGGGTALSACVPAI--
>tr|F8JMP4|F8JMP4_STREN Histidine kinase OX=1003195 OS=14057 / NRRL 8057). GN= PE=4 SV=1
----------QRH--------LPYLGLALSALLACALGPRTTVLTVVLGLTVAAALWYGLMRVASVRRPVKAMVFYTGLLLLITALVVLSPFFGFFGFTG
YLHVGV-VPQRLRPAGIVVIAALMATTQI---GGVGNAMVLVNILIAGAITYQSIEEDRRSRARAEHIGELAEAHAQLVAQAREAGVLDERQRMAGEIHD
TIAQGLTGIVTQLEAAERFDD-DPARRARHREQALRLARESLAEARRSVRALRPGPLA-EAQLPDAVGDLADRWSRTTTPVRFEVCGTPVP-LPTALEVV
LFRAAQEGLANIAKHAGASRAGLTLSYTHEVVMLDVLDDGAGFAAGPDGAAGR----PDSYGLTAMRQRLRQVGGRLEIESAPGEGTAISASVPAL--
>tr|D3Q685|D3Q685_STANL Histidine kinase OX=446470 OS=102104 / LLR-40K-21). GN= PE=4 SV=1
----------EHRWNRI-WALLPFALLAPASVIAALDTTGWIAGLILA-LAVALAGWHIWWILCWPEQSAHMAVYFLGAIALLAALRSRDEVFVIAVSGF
FPMAFVALPGAWAYPGVVLLSLLTVP-------EAPRLLFTVGVAVASFIGAMMRTVEREAIRRREVNA-----QARLVEQARQAGVTAERARLARDMHD
TVAQGLAGIVTQLETAEDPDD-TA----RRLRIARDLARDSLVEVRRSVAALRPALLD-DADLAEALAREVDAWRHRNIAATFTVTGTPVP-LDAAVDEA
VLRVAQEALSNTARHAKASRLGVTLSYMEDMLVLDIRDDGEGFAVDAEPR--------QGFGLTAMRQRVEQLDGSVHIESKPGAGTAVSVSLPLD--
>tr|C9Z6U6|C9Z6U6_STRSW Putative two-component system sensor kinase OX=680198 OS=Streptomyces scabies (strain 87.22) (Streptomyces scabiei). GN= PE=4 SV=1
----------ERRWDQF-HTWGPYGLLGVSTVLALATSEVDAAWYATGALIAAAVLLQVWWHITRTDPSWAGTGYYVVRWAFAFALTWINPFFAFFAATG
YMDADELIPGRWRRLGLFASAVTVAGAQS---SGLPPALLAANYGLQMVVAHLTEQEEQRARERTATIAELERTHAQLLVQAREAGVADERRRLAAEIHD
TIAQGLTGIIAQLQVVANAP--DPETARAHLARAGDLARHSLGEARRSVHNLAPVALE-HDGLPEALKKTVAEWAERTTRADFTATGRVEP-LHEEVSAT
LLRIAQEALSNTARHARARRVGVTLTFLGEEVILDIRDDGRGFDPLAVPARTR----AGGFGLDGMRVRAERIAGTLTVESEPDHGTALSARVPLV--
>tr|H0JVD7|H0JVD7_9NOCA Two-component system sensor kinase OX=1114960 OS=Rhodococcus pyridinivorans AK37. GN=AK37_18368 PE=4 SV=1
----------DDPWLRT-YRWAPVGMLATGTVLSVGTATMSPARYTAAVLTAVAVGLELWRGRRMPE---GDAVYYLLRSALAFVLSWLNPFFAIYAASG
YFDAHAMLPDRWIRFGLIVTAVTVAGSQA---GGLPPLLVVLNASISMLMMRLAERDEQRSLERLAAITELERTHAQLLVHAREAGIDDERRRLAAEIHD
TLAQGLAGIVTQLQAAQDTA--DPEAARRHVERATDLARRSLGDARRSVRNLAPEALE-HRTLDDALAHEVERWSAEHIRVDLTVTGTTEP-LHDDIGVT
LFRITQEALANVAKHSSAHRAGVTVSYMDDEVSVDIRDDGCGFDPCATPG--------DGFGLRGMQSRADRIAGVVDVESEPGVGTAVSVRVPLI--
>tr|G2NZJ8|G2NZJ8_STRVO Putative signal transduction histidine kinase OX=653045 OS=Streptomyces violaceusniger Tu 4113. GN=Strvi_3805 PE=4 SV=1
----------ERHSDIL-FGGLPYLLLFLSTALSVVHGPPPARLLTTLGLAALAALWILGTYTLRRSRQPRTAVYFAGLLALSAALMARDQVFMVFAATG
FLQALVLLPTVWALVSVAATSFVVNTVP----DGFPRAAIAFQTVVIGWINLLSSRLNEQHQRRKRTVAE----HAQLITQAREAGVLDERQRMAGEIHD
TLAQGLAGIIRQLEAVEHAEG-DREVWRRHLVAAKDLARDSLAEARRSVQALRPEQLE-SRTLPDALVCLVEGWSRGRAKVAFATTGTATP-VHAELEAT
LYRVAQEALANIAKHAEASKVGITLSYMEDVVVLDVLDDGVGFDPAAAAAAAG----TSGLGLVAMRRRLGRVAGTLDIESARGEGTAISAAVPVI--
>tr|G2NQT3|G2NQT3_9ACTO Integral membrane sensor signal transduction histidine kinase OX=862751 OS=Streptomyces sp. SirexAA-E. GN=SACTE_4647 PE=4 SV=1
----------EQRREQF-HRYGPHAMIGLAVLMAWLSAGMSRATYTAGGLAAAAWALQVWWNRSLPAGSWSGRVYYVLRSAIGFALCWCNPFFSVYAILG
YFDAGTLLPKRFVRAGLLFTAATMAGSQS---GGLPPALFALHAALAFLFGDLDAREAAKARRQKETITELERTHAQLLLQAREAGIADERRRLAAEIHD
TLAQGLAGIITQLQAVTSTAGSDPALARQHLDRASALARHSLGEARRSVHNLVPAALE-DDDLPQALGKTVAAWAGRHVRAEFTVTGTVEP-LHDEVGAT
LLRIAEESLANAARHASATRAGVTLSYMGDEVTLDIRDDGRGFDPTALPPYSG----AGGFGLGGMRARAERIAGTVTVETGPGLGTAVSARVPLV--
>tr|B5HMG2|B5HMG2_9ACTO Two-component system sensor kinase OX=463191 OS=Streptomyces sviceus ATCC 29083. GN=SSEG_08411 PE=4 SV=1
----------DRYWERL-HVWGPYGLLGTGLVLAVVSAGDGPVWYLIGALVGAALLLQTWWQGTRVRPSAAGTVYYCARWAIAFLLTWLNPFFAFFAASG
YMDADELIPGRWRRLGLFASAVTVAGAQA---GGLMPALLAANFGLQSVVAHITEQEEQRSRERTSTIE-----HAQLLVQAREAGVADERRRLAAEIHD
TLAQGLTGIIAQLQVVVNTP--DQAQAREHVHRAMDLARHSLGEARRSVHNLAPVALD-DAGLPEALKQTVADWGERTVRAEFTVTGIAQQ-LHDEIAAT
LLRIAQEALSNASRHARAGRLGVTLTFLDEEVILDIRDDGVGFDPLALPPRTR----TGGFGLDGMRARAERVAGSLTVESEPGHGTALSARVPLV--
>tr|I2NBU4|I2NBU4_9ACTO Two-component system sensor kinase OX=1114943 OS=Streptomyces tsukubaensis NRRL18488. GN= PE=4 SV=1
----------DRHWATV-LKWHPYWLLATGTLLSVARPEPAGGRIATVVLIVAALVLQLWWGRARTGPDAVSAAYFALRWTLSVVLTWLNPFFAFYAATG
YIDNNELIARRWRRAGAFASSLPLAAAQA---GGVPFGLLLVNNALLTMVGYFVQHEEERSAARAATIGELERTQAQLLLQAREAGIVEERRRLAAEIHD
TIAQGMTGIIAQLQVVSGTA--DPATAHEHVERAAALARHSLGEARRSVQNLAPVGLV-HDTLPQALRKSVAQWADQHVYADFTLAGEALE-LHSELSAT
LLRITQEALTNAAKHAGASRVGVTLSYMDSEVTLDVRDNGRGFDPLRLPKRTG----TGGFGLEGMRSRAERVAGSLTVESEPGYGTAVSTRLPLV--
>tr|D9UZP5|D9UZP5_9ACTO Predicted protein OX=591158 OS=Streptomyces sp. AA4. GN=SSMG_04491 PE=4 SV=1
----------HRWFSRT-ETLLAWLLLAVSVLLTALGSTKPDDRSTTLLIAAGAAGWLLLTTVLLRDHPLTAAVAFAGVVTLGAILEARETYFVIFMVYA
FFAAMRMKPMVLAVLGIGITSLLINTMTL---GG--PGVWISLVIVQTAAVFAAVG--RQNAERKRMLDQ----QRQLLAQAREAGVLDERQRLSQEIHD
TLAQGFTGIITQLEAAAQARD-DTAEWERHLAAATQLARENLTAARRSVAALRPEPLE-AATLPEALAEVARLWSERTVPAEFSTTGTAVP-LHPELEAT
LLRITQEALSNVAKHARASRAGITLSYMGDEVTLDARDDGVGFDPAHPPAPSA----EGGHGLPGMRRRAERLAGALHVESEPGGGTAVSARLPAI--
>tr|D7B7Z6|D7B7Z6_NOCDD Integral membrane sensor signal transduction histidine kinase OX=446468 OS=JCM 7437 / NCTC 10488) (Actinomadura dassonvillei). GN= PE=4 SV=1
----------DRWWDGF-LAAAPWALLLPSAALVLSRPVADWTHAVTVGLTALTAAWV-LLGYTRDGRPLPAGIHFAVLLALASALMAHDTLFMMFTVSL
FFRAMA-LPRRLTLVGIAAVALYTNTGTD---TERPFVITIQTVAVGGGLVIASKAAEQHRERRVTV-------HAQLLTQAREAGVLDERQRMAREIHD
TLAQGLAGIVTQIQAAQRVWE-DPGAARPHADRALGLARESLAEARRSVQALRPGQLA-ESQLPEALGELTRRWAEEHVRPDLDVTGERVA-LSPAIEVV
LFRVAQEALTNVARHADASRVGVTLSYSDDVVLLDVRDDGRG--ITGHNQH--------GFGLSSMRQRVRGIGGALEIESGEGEGTAVSATVPAI--
>tr|D2B7Q9|D2B7Q9_STRRD Histidine kinase OX=479432 OS=NI 9100). GN= PE=4 SV=1
----------QPPFL-L-VNVVPYALLALLVVILMIVEDWAGGLLIDLGLCGLAAAWMLGMFTLWWDRPRIMGMFVAGLLVITAVLVARHPAFGLFTPAA
YVYSFTVLRWPWRLLGVAAAAVLAGTAQA---SGIPKIIVAFNIAMMCGCAWVLRLAEQEEERREQALEELSRTHAQLLAQAREAGVLDERQRMAREIHD
TLAQGLTGIIAQLQAAEQMHE-VPAPWRRPFGAVKNLARESLAEARRSVDALRPEPLQ-TARLSDALAGVADRWSKLHLPVQVTTTGTARP-MTPEAEFA
LLRTAQEALANVAKHAGASRVGVTLSYLEQEVALDVRDDGKGFDLASLEAG--------GFGLTIMRQRVEGLSGSLRVESEPGAGAGISACVPLT--
>tr|G8S5W0|G8S5W0_ACTS5 Histidine kinase OX=134676 OS=Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110). GN= PE=4 SV=1
----------SRRHSGVALA-------GSTVLAVIATWTDLPQLPLTLGVVGATLVWILAFRALRYQRAPSIALF-VALIVLSALLVWCNPLFGFFVWTG
YLFTAYMLPGWWALAGAAAVAVVTATAQI---GGPALTLLVLNAGISMTMTWNEIGKQRTSERRIRTIDALAQAHAQLLVQAHEAGVLDERQRMAGEIHD
VLAQGLTGIVTQLEAAEA----QPADRERHLATAKRLARESLTEARRSVQALRPQRLD-GAALPDALGEVVETWAGMHVRADLILTGTARR-LLPEIETT
LLRTAQEALANVARHANAGRVGLTLSYMEDMVTLDVRDDGDGFDPARPREVTA----AGGFGLDAMRERLARIAGTLEVESESGGGTALSACVPAI--
>tr|I4ET09|I4ET09_MODMB Two component signal transduction histidine kinase involved in sensing cell wall stress response OX=1144889 OS=Modestobacter marinus (strain BC501). GN= PE=4 SV=1
----------TAR-VV--GGVLHLAFAAVVAVALVEALD----GDR-PLLVAALAVWALSY-LLWAAVDLRAAGFLAVHVAVVAVLAWQQPSLLFV----
---MWVAYPLVWTLPAGVLWTLVLAAATA---GPLVAE--LLGAALSLLMGLWVHRLLTLSVQRDQLIAELQATRDELAVAHHERGVAAERERWAREVHD
TLAQGYTSIVVLAQTVAAQLPADPLAAAERVALIEEVARENLGEARAMVAAFAPVALD-SSTLVEALQRLAERFGRETLATRLDTSALGDG-LSRAEEIV
LLRGAQEALANVRRHASATAVVLRVSRVGTGVSVHVEDDGVGF--DAAAA--------PGVGLAGLRDRAAQVGGAVDVVSAPGEGTRVTVRVPVR--
>tr|D2AXF0|D2AXF0_STRRD Histidine kinase OX=479432 OS=NI 9100). GN= PE=4 SV=1
----------IHDWDRV-WRALPLGFLGVATLIAEADPSVPSHRAVTIALAAAVAVWHWWMVLAWPERAAPMACYFAGLLALAWVLSSRHPAYGLLVFAC
FPMAFAALPGRYAYLGVATTALVAVG-------G-PSSVPLTGAVLAAFIGWSIRAMEAEVERRHAANRALESAQGRLLAAARQTGVAGERGRLAREFHD
TVAQGLVAIVTQIEATEEAVN-DADAVRRRLAVVRSLARESLAEVRRSLDDLRPGPLA-ETRLPEALSALVSGWSATHLPAMLTVTGTARL-LHPEVEVT
VYRAVQEALANVARHAEAGKTGVTLSYMEDVVVADIRDDGVGFDSSGAGG--------GGFGLTAMRQRVVRLAGNVEVESAPGQGTAVSVTVPAI--
>tr|E9UU64|E9UU64_9ACTO Putative signal transduction histidine kinase OX=408672 OS=Nocardioidaceae bacterium Broad-1. GN=NBCG_02250 PE=4 SV=1
----------DQRWVR--LKVLPLALIVLATTICIATLPPSTLRAAFGGLVAAVAVWSWWWAYV---HGGPHPVGYIGRTLLIAVLTVMHPLFCIVAWVG
FLDAFDSFRGRLRWVAMGVTAVIMAVGQT---GGPPPLLFVVNFGLATLMGHYSEHLDAISRERGETI------QEQLLAQSRSAGVRDERERLAREIHD
TIAQSLAGVVAQLQAAQGSS--DAEDVRRRVARSTEMARTALVEARRSVQDLAPAELA-DASLSDALSALVEGWRDDHVEASFVVVGEATA-LHSEVEAT
LLRIAQEALANVAKHASARRVGVTVTFDGSEVILDVRDDGSGFDPAAPRR-SS----A--FGLGVMRDRAQRLTGTFTLESAPGSGTAVSASIPAL--
>tr|D2XDW7|D2XDW7_9PSEU AzicR1 OX=703222 OS=Kibdelosporangium sp. MJ126-NF4. GN= PE=4 SV=1
----------------V-TGVVPYTLLGLLAVVTVPIRWSDGQPAVDLVLCALAATWMLWVFTLWRERPFVMAVFFTVLIVIMAVLVVRAPWFGFFTPAG
YIFAFRVLRWPWQVVAVAAVAVLAGTAQA---YDVDKAVVVANVLPMCAFAWFAQRGELRNEERVRALADAREAHEQLVTQARQAGVRDERQRMAREIHD
TLAQGLTGIISQLRAAEHAGD-DPAGWRRHLAAATGLARESLQEARRSVHALRPEPLR-TARLGEALGSVADRWSTLNIPVQVTTTGTASP-MRPEAEVA
LLRAAQEALSNVAKHARASRVGVTLSYMEHEVALDVRDDGGGFDPALPGNP--------GFGLVAMRQRIEGLSGSLQVESEPGAGTGISARVP-L--
>tr|I0H9L3|I0H9L3_ACTM4 Putative two-component system sensor kinase OX=512565 OS=/ JCM 3121 / NCIMB 12654 / NBRC 102363 / 431). GN= PE=4 SV=1
----------EPPRL-L-VTAVPYGVLALLTVYLLADWRANAG----LLLCAAAAGWMAGMFVRY---PAMM---FCGLLAITLLLVLREPAFGFFTTAA
YIYAFAFLPWPGRVPAIAAVAVVAGIAQA---SSFDKVIIALNVLIMTVMAWVLRLDE-------RNSDELSRAHARLLAQAREAGVLEERQRMAREIHD
TVAQGLTGIITQLQAAEQRHE-VPDEWRRPFDAITGLARQSLTEARRSVDALRPEQLE-TARLADALTGVAERWTALHLPVRVTTTGTPLP-LPADAEFA
LLRTAQEALANVAKHAGATRAGVTLSYLEHEVALDVLDDGTGFDPSSLKDG--------SYGLTIMRQRVEAFGGTLQIESEPGAGTGVSARVPVR--
>tr|K0JW84|K0JW84_SACES Putative histidine kinase OX=1179773 OS=NBRC 15066 / NRRL 15764). GN= PE=4 SV=1
----------ERRLGVL-ANLIPYLALLLPTLMYLVLVPDPPERLVTLSIVAGAVAWMLWWHTLWRARSGLMVVFFLGVLVFYAVLGLDDPIFGFYSFAG
YVYAIDCLHGRMKFVGVLINALIASASLY---GGFPSYVVITFFIVMVAMTFTTLGTAEQSRRRKEMVAE----HAQLLIQAREAGVLDERQRLAGEIHD
TLAQGFTGIITQLQAVDEP--------SRRVDTALRLARENLAEARRSVHALRPPALE-DANLPDALVEVASGWTDQTVPASVATTGAARP-LHPEVEVA
LLRTAQEALSNVAKHASASRVGLTLSYMEDVVTLDVRDDGTGFDPGRETE---------GYGLVGMRQRVSRLAGALAVESEPGAGTAVSASVPAI--
>tr|K0JW31|K0JW31_SACES Putative histidine kinase OX=1179773 OS=NBRC 15066 / NRRL 15764). GN= PE=4 SV=1
----------ERRWNHA-WALAPFGLLLLTCAVSMVFDPAPVERLVTSGIAVGLAVWHWWFVVAWCGRNWAMALYYVGLLAFTVVLVLRNDAFLLFVPAC
YVLAFVTLPGWAAYLGVVAANL-------------PWTLLAVVTPLAALIGGMIRAMEREAIRRRETNS-----HAMLVEQARETGIAEERARMAREIHD
TVAQGLTGIVTQLEAVEEPAP-LAGPVRDRLDTARRLARTSLVEVRRSIEALRPGPLQ-DARLGDAVRQTVTTWREQYVEATFTVTGTPLP-VHSEVEVT
VLRAAQEALSNVGRHAEARRVDVTLSYMEDVIVLDVRDDGAGF--DPSTS--------DGFGLTALRQRVRALAGSVDFESAPGAGTAISVSVPVI--
>tr|D7CBC5|D7CBC5_STRBB Putative two-component system sensor kinase OX=749414 OS=Streptomyces bingchenggensis (strain BCW-1). GN= PE=4 SV=1
----------IRRWNS--AGWVVFGLLP-PAVAVLDASP----ARR-YWLLGLLTLIALCY-TVLTRPDLRRRTYLVVLALVLGATSYLLDGGAAF----
---YVVSLPQFWAPRDAITLSGAAAATVF---GGMLGNVVVVAYVAGVGLGLWVHRFVGQSHEREQLATELAVTQKELAAAYQQQGAAEERERLAREIHD
TLAQGFASIVVLAEAARAVTVTDPVRCAEQLTSIEQTARENLAEARVLVGSAPESGVA-PGSLATTLRRTLDRFVQDTLTVTTELPDI--D-LDQRTRVA
LLHCTQESLANVRKHSGASTVGVVLTELAGGVELEITDDGCGF--VVEES--------RGFGLDGMRRRLAELDGELAVTSSLGDGTRVLASLPTH--
>tr|I6Y0G3|I6Y0G3_PROPF Histidine kinase OX=767029 OS=Propionibacterium propionicum (strain F0230a). GN= PE=4 SV=1
----------MERYESIAARWGPFVLLAVSVIIGWALTG----IEPGGMLVSLCPTVLILLGRVVRPPSRAAFVFVAGNLLLALASSLLNPFMCIYVFSS
YPDVERLVTGSFRVPATIATGLVIAVGQA---GGIPGLLALVNIGIAFLMLTLSRERERQVRIR-------EEAHEELMTQARQMGIDQERARLSREIHD
TVAQGLIGVIRQLEALPSSLD-DPA--QERVRRAEQVARDCLTEARRAVQALAPRQLD-DDPLADALHEIIKGWGRVNIVTELDADDA--P-ATSPHDGV
LIRVAQESLANIARHSDASQVWVRLDGTPAGPRIRITDDGVGFTP-----A-------AGHGLSGMRDRLAEIGGSLRVDSAPGKGCTVTAVVP----
>tr|D6ACT1|D6ACT1_STRFL Two component system histidine kinase OX=457431 OS=Streptomyces roseosporus NRRL 15998. GN=SSGG_05989 PE=4 SV=1
-------------------------------------------TAAVVVVTMLTAGLYAAGAVRSARPRRAGAWWLGGLWVLWAALLVLSPDALWVAFPL
YFLQLHFLPMRWALPAVVVTAAAAITSFVVHRQEIEPGAFIGPLIGAAVAVAGYDALFRESERRRELIVELVATRADLAEAERTAGTLAERERLAREIHD
TLAQGLSSIQLLLRAAERSLPENA-PATPHVRAAREAAQANLAEARSFVRALTPPDLE-HGSLAAALERLCARTTAPELTVRFAVSGTPVE-LPTPYEVA
LLRTAQSALANTVRHAEARRAEITLSFMDTSVALDVVDDGRGFDPSGAPVGTG---GDGGFGLPAMRARAGSLGGALSVESAPGQGTAVALTLPLP--
>tr|E2MXF5|E2MXF5_9CORY Two-component system sensor kinase OX=553204 OS=Corynebacterium amycolatum SK46. GN=CORAM0001_1174 PE=4 SV=1
------------QLLRFALDVLVLVLLAVCVV------P-DPQ-WRIITYAACFLAVYIAGSVGPIGRARTKPGWLVILLLCWAALAFATLDASFLVFPL
FFVILQVTGGLTAVIMVAATTATAIGA-IAVHTPLTFGGVLGPILGGTFVLTVFRLLQKETIEKTKALEELSAARAHSEALSRRAGELDERARLAADIHD
TVAQGLSSIQLLLHSVESRMD---QASVDSLQLARKVAADNLAETRRILQP---APLE-GADLSGALEKVCSSTVLGD-AVSFCVDGTPTR-LPATVEAT
IIRVAQASLANVIKHAHATRCRVTLTYQPDEVLLDCVDNGIGFDPT---APTN----DDSVGIANARRRVEKLGGTFTIESEPGRGCGVSVSIPHE--
>tr|C0XR02|C0XR02_9CORY Histidine kinase ChrS OX=525263 OS=Corynebacterium lipophiloflavum DSM 44291. GN=HMPREF0298_0872 PE=4 SV=1
------------VFLRVSLHVLVAVLLAVGL-AGA-LQE-G-----ALCLGALFAVVYLVGTV---------AWWLAVITALWVALTWVSPTFVWLEFPL
VILVSYLF----GLLISAVILGYTLT------PESGVGGIVGPTIGTAMALLIYSALRREADHYKQLVVDLQAAQMELAAAEHSAGVSAERARMSREVHD
TIAQGLSSIVLLGRALDKQLTA---SARETLDTIRSTAADSLTEARRIVA-G--DAGP---PLSVRVERLA-QRALGS-HIE--VVD-----LPEPAANV
VERVVREGLSNIVRHAGATQAVVTVDRLGDQATVDVYDNGRGI--------TG----EEGFGLRGLRERLREAGGKLTI-----EGNVLAATLPVK--
>tr|D4YKR4|D4YKR4_9MICO Probable sensor histidine kinase OX=585530 OS=Brevibacterium mcbrellneri ATCC 49030. GN=HMPREF0183_0524 PE=4 SV=1
------------RAMRVTLHVAFAVMLGVGVVRFIDQHP-AVL-MMILILTLMLAGLYLVGTVAEMQHSKRS-WWLAAILILWAGLMLSSMSFAWVSFPL
FFIVLHAYRPYVAAPVILVMLFTILAS-SYRHGVFNTGYLLGPTIGACVATVVYQELRKEAEAMGNAYEELQRAQTQISLSQHRAGRLAEREKLAADVHD
TLSQGFTSILLLSRSLEPHVD---TSGRETLHLIEDTAQSNLQQAREFLHG---SPLG-TSDLHPTLRAECASTAVGA-DIDFEVTGDPYP-LTPEVKQS
LIRATQSLLSNVSFHSRCTRAKVTLAYWDAHVSLDVVDNGVGF--------AG----AYGYGLRALTERVASVRGQLSVETAVGEGCSVHIVIPVE--
>tr|C2CT39|C2CT39_CORST Histidine kinase ChrS OX=525268 OS=Corynebacterium striatum ATCC 6940. GN=HMPREF0308_2568 PE=4 SV=1
---------------RAGLHVMFAFLLLFGL-RAG-LDE-R-----ALGLAVALAVVYALRRV-----------WLVGLCVLWCGLMVHAQDFMWLEFPL
VFAFLSSL----GIACSGLLWALAAF------AEWTIAAAIGPFIGTAFAIGAGRMVQAEAAHHAAVARQLRATQAELAASEHQAGRLEERERLSREIHD
TVAQGLSSIVLLSRAAQKD------PSPETLALIEKVASENLSEARRFVS-E--LAAP---SLEEALQQVV-AAALGK-DTD--VSG-----VPEAHRQD
LLRAAQEGLNNMLKHSGARRAVVTLGCFKGETTLDIVDDGEGMDP----TSPS----QGGFGLRGLRQRVEGHGGTLTV-----EGTALAIRIPQK--
>tr|F4H6S0|F4H6S0_CELFA Integral membrane sensor signal transduction histidine kinase OX=590998 OS=/ NCIMB 8980 / NCTC 7547). GN= PE=4 SV=1
------------FWVRRGWDIGFYAITAVAAVPILVEADSPGALVAGLGLAVLVVAYLLLGRPAIRGDVRLTRPYLLVLVAVLLVEVSVANLGAFVAYSQ
IWFFSTTRLEGVAWCVVLTVAFATALVVADPSAVAEPRALLGLVGQAIALGLWITWVSEQSEERAALVERLGAAQAELASTHHAAGVLAERARLAQEIHD
TLAQGFTSVVMLAQAASAEIADRLAPAAERVDQIEAVARDNLAQARALVAAFGPPELE-SGTLADALDRLATRFEAETVRVEVGLD-GLGA-VGPEQAVV
LLRAAQEALANVRKHAGAQAVRLSVRRDGDDVLLEVADDGRGLPVDV----------VEGVGLRGMRERVDAGGGTLEVGSGPGGGTRVSVTLPTA--
>tr|D1BCA7|D1BCA7_SANKS Signal transduction histidine kinase OX=446469 OS=ST-74). GN= PE=4 SV=1
------------AWDRTFWHVAFYLLTGFTAAAIVVSDDRASSIPSLVALGVLVVAYATFGQRAARGPDGAAWAYLALLVVVTCVVTSLDPLGTFVAYSQ
VWLLTPSIRVGAWLSALLAVAS---TLALLARLRDIGEGSWATVFQMMLMGLWLHWILRQGVQRAALLESLQATRAELGRTQHAAGVAAERERVAREIHD
TLAQGFTSIVMLAQTASAEAQGDDEQVARRLELIERTARENLAEARSLVSASSPAPLA-GSSLPEAIERLGARLTEETIEVVTRCT-GPAE-LPSPVEVV
LLRTVQESLSNVRRHSGASRVSVTLETTSSEAVVTVTDDGTGLHPSS----------VEGFGLRGMRERVTASGGSVRVEDAPGGGTRVVARVPTS--
>tr|C7Q8I4|C7Q8I4_CATAD Histidine kinase OX=479433 OS=102108 / JCM 14897). GN= PE=4 SV=1
------------SWK-ARWWAVGWHFGLAISVVLVAVEHK--PVWLYGALAGMSLSYLLLQHRLLDGNPRAVYYHLAIVCTLCFAMVWAD-LSLSSVVLS
QFAPLAGFRIAILAAAAAVLT-F-PIAA---SDGFTSGDLVAWGLTALFIGLFFGEMLNDHDRRGALIRELEATRAELERAHHEAGVREERERLAREIHD
TLAQGFTSLLMLVQAAEATLDTDPATTRERLDLAARTARENLAEARALIGGDPTAGL----PLDAALQRAAARIGEELMATSVDIGGSART-LTATVQVV
TLRVAQEALANVRKHARAASVTVWLTYGADRLTLAVEDDGVGMPEAP----------CGGFGMRSMRERVEQVGGELTITSAPGAGTRVEAEVPYE--
>tr|C5BYM1|C5BYM1_BEUC1 Histidine kinase OX=471853 OS=Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432). GN= PE=4 SV=1
----------------REWSSLVWLYVPLLALLVLGVATPM-VLAVSAAVVVWHVGWVVL-HPWPERFLPMA-VYLVGLFVFFPV--------LFAM---
CFVVLPGGWAYAATAVTGVLT----VTDR---DGLDLSGPFLAILLGSVIG-WTIRSSERQERRERLRVELELAHEDLVREAHDAGVAAERARLAGEIHD
TLAQGLAGVTAQLEAAEAEL-GDAHPSVRRVRLARDLARESLREARRSVAALRPGPLA-EGRFLEAVRGAVAAWQERSATADVRLAEPPDR-LGADVEHA
LLRALTECLANVARHARAGTASVSLTYPPGVVVLRVRDDGVGFAPGS----------DGGYGLTALAARATALGGTVDVVSAPGAGTTVTVRLPRQ--
>tr|G2P312|G2P312_STRVO Putative signal transduction histidine kinase OX=653045 OS=Streptomyces violaceusniger Tu 4113. GN=Strvi_3041 PE=4 SV=1
------------VYYRRRWD----VYFAIVFAFVLGGSDPGTLRVVAASFFAATAPWYVLGRPLAEEDQPRALVYLVGLFLLFVVPSALVGETRFALAPQ
CFMLLRMRGALIAVTVINVVP----VVVWAFVERPDSGDLFFNSLFALIIGSWIIMVLQQSAERARLIAELDASREEVARLSAAHGALAERERLTREIHD
TLAQGFTSLVMLVQAVESEL-DHDMPLARRLGLMARTARENLAEARALVAGAGPADLD-GSSLPDALRRLAARHGEQTSAARVEVSGAVRP-LPAAVEVV
ALRGCQEALSNARRHAGPGTATIALGYGEDALRLRVRDTGRGFDPRP----------REGYGLAGLRARAGEVGGTAEVTAAPGEGTTVTLELPVQ--
>tr|D2PW73|D2PW73_KRIFD Histidine kinase OX=479435 OS=Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399). GN= PE=4 SV=1
------------VWIRLGWHVVFYTLLAVVALAAATSDLSSQKTAYLILVAVLALAYRFIAMPMTSRNVLRSNLYRLLMIGCIAAAVAIYPQSVFIVSPQ
IWLLSQRTLDAIVLSLLLLVAV---GTAQLWAAGWTTDAFWNILPWMSLMGTWIDRVISQSEQRAELIEQLEAARDELAEAHHTAGVMAERERMAREIHD
TLAQGMTSIVMLAQTAAVELQGGTASAATRLAAIEDTARENLAEARALVAAFTPVALA-EAPLADVLRRQAERFAAETVDVQVALDDEVAA-LPQGQQVV
LLRAAQEALANVRKHAGATSVLITLTMAPDGVRIEISDDGSGFTAAP----------VTGYGLAAMRGRVEESGGTVQVDSAPGRGTRVQVLIPST--
>tr|F7ZZF6|F7ZZF6_CELGA Integral membrane sensor signal transduction histidine kinase OX=593907 OS=Cellvibrio gilvus (strain ATCC 13127 / NRRL B-14078). GN= PE=4 SV=1
------------FWRRRAWDIAFWIMVAITAAFSVPTAPSVAGSAALAGYVTLVVAYHLLGRRARADDTRLTQAYLVVLVVVTSTEAWLVELGIFVSYSQ
IWFFAVDRVRGVMWTVALTLGI---IVATALRVEADPGDLPEIAGQAIGLGLWVTYVAEQSEERAYLLDGLRETQAALAASHHAEGVLAERARLAQEIHD
TLAQGYTSIVMLAQTAAAELEEHTGSARERVEQIEAVARDNLAEARALVAAFAPPALE-DGDLPAALRRLGARFAAETTAVDVAVD-DVAD-VPQDVAVA
LLRAAQESLANVRRHAGATHVHLRFARVDDDVELEVTDDGRGLRDDD----------LEGNGVRGLRDRARAGGGELALVGSVGRGTRVLLRLPLG--
>tr|D7C133|D7C133_STRBB Putative two-component system sensor kinase OX=749414 OS=Streptomyces bingchenggensis (strain BCW-1). GN= PE=4 SV=1
------------FWAARRWNAVCWVLFAAMAVGLAATDRP--GGSRYGALALLGCVVLCYALLRFPNPVVRPHVYLSVLVLALGGIAYLRSSYAMVTLPH
YWMFGRTPRSMGFLGLATAAT----LAGTWSRQGWSLEFFSETLVSTVLIGLWAHSVVAQSTERARLIVELERTQAELSEAHQRQGAADERERMARDIHD
TLAQGFASIVVLAEAARAGLAADPARSAQQLRSIESTARENLAEARELVGSAQRQDAA-AGSVARTLRRILDRFAEDTLTVAADLADV--G-CDQQTRIA
LLRCTQESLANVRKHARASTVGVILARRPYGVELEVTDDGTGFVPEE----------SAGFGLDGMRKRLAELGGRLTVTSSVGDGTRILAVIPLE--
>tr|A3TPE1|A3TPE1_9MICO Two-component system, sensor protein OX=313589 OS=Janibacter sp. HTCC2649. GN=JNB_15583 PE=4 SV=1
------------MWRGKWWHLSCYAIIATACAIALVDAPGEHRLPTLLLLLGIALAYTLFGRRIQREGTVYAVLYQLSAWACVLAVILIDPESWFCLFPQ
IW-ATFEKRHALIGTGLALLAL---FTATVLPSDDPADMVPAALVSVATLGLFIHRIIREAEERALVIDELQSTRAQLAAVEHAQGVQDERSRLSREIHD
TLAQGFTSVIALSRAASSALEDDVDKARERLAMIESTAVDNLAEARVIVAELTPGHLQ-SRTLVEALARLAETMTRETIQVSSSVAGEPAP-LGGNAEVV
VLRGAQEALSNVRRHSGAKAAAVTLTYEAERVALEVKDDGAGFPTTA----------QMGFGLDGLRSRATELGGEVSIARAKPRGTRLVMELPR---
>tr|H2K7B0|H2K7B0_STRHJ Putative two-component system sensor kinase OX=1133850 OS=Streptomyces hygroscopicus subsp. jinggangensis (strain 5008). GN= PE=4 SV=1
------------LWATRRWNTVCWALFGAMAVGLVATAPP--GGSAYQALGLLACVVLCYAALRFPNPVVRPHVYLSVLVLALGGLAYLGSSYAMVTLPH
YWMFGRTPRSMVFLALATGST----LTGALVRQGWSAEFFGETVVSTVLIGLWAHSVVEQSSERARLIEELERTQAQLSEAHQRQGAADERERIARDIHD
TLAQGFASIIVLAEAARAGMAGDPARSAQQLRSIESTARENLAEARELVGSARQPGVA-TGSVARTLRRTLDRFAEDTLTVVADLADP--E-CDQQTRIA
LLRCTQESLANVRKHARASTVGVVLARRPYGVELEVTDDGTGFVVEE----------SRGFGLDGMRKRLAELGGRLTVTSSVGDGTRILAVVPLT--
>tr|G0FY71|G0FY71_AMYMD Two-component system histidine kinase OX=713604 OS=Amycolatopsis mediterranei S699. GN=RAM_27550 PE=4 SV=1
------------GWLLLLGWHASFALMGVVLVVLAAFERD--PWFVYAVVALIGVAYAVVGAPLGGAPAGYGWLFLALAFAGTLGMVAVDGLMSYVLLPA
AFALLQPIRIAVWACLAVTLASDVLILG---RRGWTPGAVSDVAVQTLLVGFFVTQLLTENRRRGELIAELENVRSELTESYHEAGVQSERYRLAQEIHD
TVGQGLTSLLMLIRAADAAIPADPERAHERLALAQKTATENLAEVRAVISASGPAGLS-ASPLDVAIGKVVARLGQELIEASAEVLGEPRA-PSTDVQVV
LLRAVQEALANVRKHAHATRVRVRVRYHARSVQLEVADNGRGFVTGG----------PSGFGLAGMRARVEQVSGMMTVSSTPGSGTTIKIEVSC---
>tr|H1Q5W6|H1Q5W6_9ACTO Putative two-component system sensor kinase OX=1120227 OS=Streptomyces coelicoflavus ZG0656. GN= PE=4 SV=1
------------LVPELRWNAAGWTLFGLLPPAVAVLDAS--PARRHWMLALLAVVALCHTAVVRPNRVLRPHAYLVVLTLVLGATSWLLNGGATVSLPQ
FWLLARAPRAVALSGAAAALT----VLGSTLGQGWSPQFLTGNVVFTTGLGLWVHRFVSRSNERQQLTNELSTAQEELMVAYQERGAAEERERIAREIHD
TLAQGFASIVVLAEAARASAVSDPGRCAEQLTSIEQTARENLAEARVLVGSAPESGVA-PGSPATTLRRTLDRFVQDTLTVTAELADV--E-LDQRTRVA
LLRCTQESLANVRKHADASTVGVVLTEHAGVVELEITDDGHGFVVEE----------SRGFGLDGMRRRLAELGGDLAVTSSLGDGTRVFARLPTH--
>tr|D7AVD4|D7AVD4_NOCDD Integral membrane sensor signal transduction histidine kinase OX=446468 OS=JCM 7437 / NCTC 10488) (Actinomadura dassonvillei). GN= PE=4 SV=1
------------------------------AIALVTSDRWPL-----GLMAAVTAVYYLFARRLVMREERPAVL-MAVLLVLCLPAVTVNPALTFLVVAV
APLCFITSPVPAAVSTVGAILLVPMPLRGLLG-WDDVNLLINGVMVGYTLGGWLGRIIEQSYERANLIRELRESRLEVVRLSEETGAMAERERLAREVHD
TLAQGFTSIVALTQAVESEMDSDPELARRHLALMRETAAENLAEARAMVAARQPVGLD-SQTLEAALDRIASRLGGELVPVDTEVLGAPTA-LSNDLQIC
LLRTAQEALANVRRHARAGHVRVALEYSPGPVELTVADDGVGFDPGRTAP---------GNGLANMRRRADDAGGAVEVGSAPGRGTRVRMSLPL---
>tr|B5I029|B5I029_9ACTO Sensor kinase OX=463191 OS=Streptomyces sviceus ATCC 29083. GN=SSEG_09625 PE=4 SV=1
------------------------------VFVLGTGYRVTA-----ALLVPLVPLFVRVGRPLLRQDPPEALLYLGAMLALFLPSAILVGETRLMTFAL
VPQCFMTLRMRWALTAVAVINLAPVVGWALV--WWPQEVFFNGLFAVVTLGSYVIRIIEQSQERAALIAELDASRHEVSRLSAAHGALTERERMAREIHD
TLAQGFTSLLMLVQAVEAELDHDVSQARRHLALMDETARLNLAEARALVADGTPADLE-GSSLPDALCRLAARHAAKL-----DVTGQVRP-LPAGPEVV
ALRSCQEALTNCRKHASAAAVGIGLAYADDSLTLFVRDDGHGFDPGAVHD---------GYGLAGLRARAAEAGGTVRVHSVPGDGTTVTVRLPI---
>tr|I0HFQ1|I0HFQ1_ACTM4 Putative two-component system sensor kinase OX=512565 OS=/ JCM 3121 / NCIMB 12654 / NBRC 102363 / 431). GN= PE=4 SV=1
------------------------------LAAVVIVDGFSSERGVAAALTAMIVLHVVIGRPLILRDYPTSRVVLLVQLTLFAIAIFAVPLSTWLMFAV
IPLIFQMVTVRLAIVLIVVTNLVPPVADLLNDPGLDIAAISTG--AGICMGLWIMRALAQSDERAALIVELEASRAELARLSHEAGAAAERNRLAGEIHD
TLAQGFTSIITLVQAADPQL------ADERLALAVRTARENLAESRALIAALSPAALA-SASLPEAVRRQAARFSEEAVPSTVRVTGEPRD-LPTRVEVV
LLRAAQEALTNVRRHAGATEVGVVLAYAASSVRLVVRDDGRGFDPAGVRSAG-----GGGFGLSNIRARAAQVGGQVAVRSGGPGGTIIELEIPA---
>tr|I9JHQ9|I9JHQ9_MYCAB Histidine kinase OX=1001709 OS=Mycobacterium massiliense 2B-1231. GN=MM2B1231_2787 PE=4 SV=1
------------------------------VAMALLNHRFPGNVPVAAALAAIAVATPTVGRRVITSRRSAAAAFAATTVTLWVVAVWSSPVAIAAIPAM
YPVLFASLSLGAALCVTGLVTLTPLAITLLTDGYLTAACTLVGLVAAPVIGTMIMTSMRQRARLSTLIDDLKESRAESARLSHEAGVAAERERLAREIHD
TLAQGFTSIITLAQAVEAELDGAPAAARAHIALIGATARENLGEARGMVTQLTPTALD-QGSVSAAIQRLCERLSAETITVTTAISRPLPE-LGMATDVV
LLRAAQEALTNVAKHSRASSAHLKLAPAAENVRLTVVDNGVGFSAASME----------GFGLRGMRTRIAQVGGTIFVSATAGGGATVTIEVPA---
>tr|I8Z824|I8Z824_MYCAB Histidine kinase OX=1001734 OS=Mycobacterium abscessus 5S-1215. GN= PE=4 SV=1
------------------------------VAMTLLNHGFPGNVPVAAALAAIAIITPTVGRRVIRSRRSTAAAFAATVVALWVIAVWSSPVAIAAIPAM
YPVLFASLPLGAALCVTALVTLTPLAITVLTDGYLALACTLVGLVAAPVIGTMIMTSMRQRARLATLIDDLRASRAESARLSHEAGVAAERERLAREIHD
TLAQGFTSIAALTQAVEAELDSDPTAARAHIALIGNTARENLSEARGMVTQLIPPALD-RGTVCAAIQRLCERLSAETIAATTAISRPLPE-LGMATDVV
LLRATQEALTNVAKHSHASSVHVRLAPTAQSVRLSLVDNGIGFTDDSME----------GFGLRGMRARIARVGGTISVSPTPGGGATVTIEVPT---
>tr|G8RUF3|G8RUF3_MYCRN Signal transduction histidine kinase OX=710685 OS=Mycobacterium rhodesiae (strain NBB3). GN= PE=4 SV=1
------------------------------VAVVLLDHRFPGNVVGAIALSAMAAVVLAFGRRVTRSPDRRAVAFVTMVVGLWILAMLASPVSVAAVIAT
YPVVFSTLPLRTALVVTTIVNLIPLGILLLTHGNLTVAITLIGVVAAPVVGTVITRSMKQRRQLALLVAELAATRAESARLSREAGTAAERERLAREIHD
TLAQGFTSIVMLAQAIEPELESDTAAAKRHVELIGATARENLAEARAMVAELTPSPLE-E-PLPAAIARQCDRLAAETAAMTVRIDGDLPA-QSMSSDVV
LLRAAQEAFANIRKHARADAVTVELTPTGTGVRLAVTDNGIGFN-GHPE----------GFGLRGMRARVAQVGGTMTLATAEGGGTRLTVEVPS---
>tr|H1JXR0|H1JXR0_9MYCO Integral membrane sensor signal transduction histidine kinase OX=710687 OS=Mycobacterium tusciae JS617. GN=MyctuDRAFT_2216 PE=4 SV=1
------------------------------FAVVVLDHRFPGNMAVAGAIAGMMLCVVTLGRRVFILPENGAVLFVGLVVALWTLALWASPVAVAAVPTI
YPLVFATLTLRVALVITTAINLIPVALVLVREGDLGIAFTLIGVIIAPVIGTVIITSMRQRRQLAALVAELAATRAESARLSREAGTAAERERLAREIHD
TLAQGFTSIVMLAQAVEPELESDTAAAKRHVELIGATARENLAEARAMVAELTPSPLE-E-TLPAAIQRQCDRLAAEIATVTVDIADDLPP-QSMAADVV
LLRATQEAFANIRKHAHASTVAVELSPSDSGVRLTVTDNGVGLNDGQTD----------GFGLRGMRSRVAQAGGAMTVSSAAGGGTTLSVEVPS---
>tr|G0G1C2|G0G1C2_AMYMD Two-component system histidine kinase OX=713604 OS=Amycolatopsis mediterranei S699. GN=AMES_8327, RAM_43410 PE=4 SV=1
------------------------------TVLVLLDERDPVRTAAAGALTALALTYLLWGRRIVRDDGHRRWTLALVVVALVAAAMLATTTTSFILFMV
CPLLFTTLDFRPAAVLNTAVILMSPASSIVNNGTLHLPMTAILVVFGVLSGKFILHVVEESRGRADLITRLEESQAEVARLSREAGTAAERERLAREIHD
TLAQGFTSIVTLAQAIESELDSDPAAARRHAELATRTARDNLTEARAMVAALAPADLA-AGSLVDAVRRQADRLAEETVPVEYEVDDALPP-IGMAGEVV
LLRGAQEALNNVRRHAAASAVSVRLSAVDGSVRLSVRDDGAGFDPDHAT----------GFGLRGMRSRAEQVGGRLSVRSSPSG-TELTLEVPA---
>tr|K0VJP6|K0VJP6_MYCFO Signal transduction histidine kinase OX=1214102 OS=Mycobacterium fortuitum subsp. fortuitum DSM 46621. GN=MFORT_05919 PE=4 SV=1
------------------------------VAVVLLRRTFGGNLPVATALAAMVGLVLIFGRNIIREADPSTAAFVSAAIGLWLIAIVAAAPAVAAIPAL
YPLIFATLPLTVALVLTFAVTLVPLALAVATHGSLPAAVTLVGAVAAPIIGTTIMTTMRQRQQLVETVADLAASRAETARLSREAGVAAERERLAREIHD
TLAQGFTSIVALAQAVQAESDSDPAAAARHVELIRNTARDNLAEARTMVTRLTPAALE-QGSLSAALRRQCERLAAETIAVEVDIDDDLPP-LRMATDVV
LLRSAQEAMTNVRRHSRASELHVRLQPAPGGVRLSLSDNGIGLRPDHVD----------GFGLRGIQARLDQVGGTLTLSVPDGGGVRVVVAVPA---
>tr|Q6ADI4|Q6ADI4_LEIXX Two-component system, sensor protein OX=281090 OS=Leifsonia xyli subsp. xyli (strain CTCB07). GN= PE=4 SV=1
-------------------------------------------------------------------------------SVAWMPLVMVAPSFAWCAIPL
FVLLHNAFSRAAALVAAAVLTITVSVSVYLLAGASDLVMMFGPLVAGLLLSFAMDALNRALDARQRLVDELVTAQDRLARTEREAGTLAERHRLAAEIHD
TVVQGAASALLLLEAAEQTWS-DRDAARVSIASAEQTLRNNLAETRRLVHRLASDSLT--GTLFEAVETVAGDAGGRA-TF----IGEPVP-LPPETEHA
LLRVVQGAVANAQRHADADRIIVTLTYYEHSISVDIADDGRGFDPKAVP-APGP---EGGYGLRAMRLRVEKLGGRLVVESEPGAGTVVAGHLP----
>tr|H2HK16|H2HK16_CORDK Two component system histidine kinase OX=698969 OS=Corynebacterium diphtheriae (strain HC03). GN= PE=4 SV=1
--------RPGAALYYRSMNVLTSVLLLVSLAGVVSLDRRSA--IVAVILSALFALFYAAAAVS-HRRAMWTKALLVILTVLWVFMLPIIPVSIYMVFPL
FFLYLRVLPIRGIILVVGA-TAIAITSQLA---QLTIGAVMGPVVSALVVIAIFEAIWKGAREREELIDELLATRNQLAETERAAGIAAERQRIAHEIHD
TLAQGLSSIQMLLRVAEQDIKSEQQAPLHRMELARSTAAENLSEARAMIAALQPAALS-KTSLEGALNRIAEHVVGPE--ISIEVDGEERQ-LPMRVEAA
LVRIAQGALGNVAKHSGATHCHLTLSYGEEEVRLDVVDNGHGFDPEQVAQRPAG---LGHVGISAMQQRAAELGGELIVESEPGQGTAVSVALPVD--
>tr|G6WZC9|G6WZC9_CORGT Two component sensor kinase OX=1079988 OS=Corynebacterium glutamicum ATCC 14067. GN=KIQ_11000 PE=4 SV=1
--------QPGATSYRNSIHILTASLLVVGLGASARLTLP---------------FLY-----------------LFVLTLVWIFMVPIVPVSIYLLFPL
FFLYLQVMPVRGIIAILGA-TAIAIASQYSV--GLTFGGVMGPVVSAIVTVAIFRTLWRVNNEKQELIDQLIETRSQLAVTERNAGIAAERQRIAHEIHD
TVAQGLSSIQMLLHVSEQEILAPKEAIVKKMRLARQTASDNLSEARAMIAALQPAALS-KTSLEAALHRVTEPLLGIN--FVISVDGDVRQ-LPMKTEAT
LLRIAQGAIGNVAKHSEAKNCHVTLTYEDTEVRLDVVDDGVGFEPSEVSSTPAG---LGHIGLTALQQRAMELHGEVIVESAYGQGTAVSAALPVE--
>tr|H5UVY3|H5UVY3_9MICO Putative two-component histidine kinase OX=1089455 OS=Mobilicoccus pelagius NBRC 104925. GN=MOPEL_135_01290 PE=4 SV=1
------------RYLECGQHLLFALLLVLGTARAVLVHGTADRGVAALVGAALTAVWYVVGAVMSARGARGGLAWFVVLVACWLGLLWISPDFSWVAFAL
FLLAIHLLSTPAALGTIAALTCCVVASQVS-AGVPSPGRIVGPVVVAAGAGLIYRRILAESEDRRRLVAELVVAQDELAATQREAGVLTERQRLARDIHD
TLAQGLSSIVLLSRAGL---AG-DDAARTVLRQIEATAADNLEEARRVVHALTPASLE-AAPLPTALTRLLERLREQTLETTIDVDGDMTT-LGTSGEVA
LLRVAQSALSNVRLHARADRVVVALTNTGDAVMLDVVDDGRGFDPARLDAAPL---GGTGFGLRAMRERLATLGGALGVDSAPGEGTTLTATVPLA--
>tr|H6RTH6|H6RTH6_BLASD Two component signal transduction histidine kinase OX=1146883 OS=Blastococcus saxobsidens (strain DD2). GN= PE=4 SV=1
----------------LVLHIAFGLLVALALLAVALGDVDGDRAVLVGALGGWALAYVLLGPAIGGRESWRATGFLVVHVAVFGVLAWEQPSLLFLGYPL
VWFLVE--SVRDGVLWTLALAFAATLGPIAWTRGDEP--LWGPGLVLAMGLWVHRV-LEQSAQRAQLIRDLESTRAELAAAHREQGVVAERERLAREVHD
TLAQGYTSIVVLAQTAAAALPGSPPVAAERLALIEDVARENLAEARAMVAAFAPVALD-SATLVEALGRLAERFGRETIATRLDTDAL-TGGLSRAEEIV
LLRGAQEALANVRRHASAGAVVLRVGRVGAQVSVHVEDDGVGFDPAAAP----------GVGLAGLRDRAEEVGGAVDVASAPGEGTRVTVRVPAR--
>tr|F6FVU4|F6FVU4_ISOV2 Putative signal transduction histidine kinase OX=743718 OS=Isoptericola variabilis (strain 225). GN= PE=4 SV=1
----------------VWWDLGFALIVTLTGVALPLGVRGTPLLVAYAALATLVVAYVAAGPAARTRDQRRARAYVAVMVAGVAVVVGGGGTGTFIGFTH
VWMLLE--PVRHAIVGCVVLGLAVTVA-LSSTEGFEAALARVAPGVVGLGLWTSLT-MRRADEHARLVGELRAAQAELAASNHAAGVAAERERMAREIHD
TLAQGFTSVVTQAQAAIAALDGEHDAARERLRLVESTARENLAEARALVAAFAPVPLQ-NGTLAEALRRLADRFAAETIAVRLEVADD-GTPRDAASDVV
LLRAAQEALANVRRHADARAVTVRLDRDAGTVGLEVTDDGRGLPPGHAD----------GIGLSGMRERVSAVGGSIDVGPGDRGGTRVRVRVPVA--
>tr|D1BWR4|D1BWR4_XYLCX Histidine kinase OX=446471 OS=/ XIL07). GN= PE=4 SV=1
----------------VWWHVAFYVAVALVVLSLVTSTPGRALVVQLACVAAIVVAYALLGRAARTREPVLTWAYLGILVAATIVAMAQGEIASLVAFTH
GWMLSE--RVRDGLVVTVALTVGTFLA-LWGATGWDPALEDVVPAVGGLGLFVART-MRQAEENARLVARLRAAQAELAATQHAAGVTAERERLAREIHD
TLAQGFMSVVTQVQVASSALDGDDAAARERLAIVEATARDNLAEARGLVAAFAPVSLQ-GGSLADALRRLAERWSAETLRAVVEAADD---PLAADEEVV
LLRAAQEALTNVRRHAGASAVWLSLEGGGGAVRLEVVDDGGGIPAATRE----------GYGLRGMRDRVVAVGGALDVQAGDDGGTVLSVRLPAR--
>tr|D2S9S7|D2S9S7_GEOOG Integral membrane sensor signal transduction histidine kinase OX=526225 OS=G-20). GN= PE=4 SV=1
----------------VGVHVISAVVWTLAVVSAAVDAVDDDRRTALAVLAALAVAYAALGPAIGAGARRRAVAYLVVLVAAFGLLGWLASGLLFLAYPH
VWFAVQ--GTLTGITWTLLLGLASAVGPLSATSARSPGLLLETG-VLALGVWISRV-LRESAERASLIAQLEATRSELAAAERERGVLAERERLAQEVHD
TLAQGYTSIVVLAQTADALLPADPEAARERLAVIEEVARDNLAEARAVVAAFRPVALD-GSTLVEALRRLAERFARETLEVRVDTGAL-DAGLRRDEEVV
LLRGAQEALTNVRRHAGATAVVLRLSRVGSQVSVHVEDDGVGFDPASAS----------VSGLEGLRGRVEQVGGEVDVASLPGAGTRVTVRVPGA--
>tr|D2ARZ7|D2ARZ7_STRRD Histidine kinase OX=479432 OS=NI 9100). GN= PE=4 SV=1
-------------------------------------------------MAAILPVYFLFGRSAILTERRRGAVYLAVLVVLFTPAAFIEPSAAFALFGL
CPQCFMVFPAKPAVGVVIVLNAGPVVRFLVENQGDTFNFLSVSTIVIFFSGIWMERIMRQSEERAALIAELEAQRAEVSRLSAERGALAERERLAGEIHD
TLAQGFTSIIMLIQAAEA------QSDPARLSLAVQTARENLAEARALIAALSPAPLD-GSTLDEALVRLAGRLREETIATAFSLRGESRP-LPPPTEVV
LLRAAQEALANVRKHAAAGRVEVSASYGPETVALEIRDDGRGFDPAVAE----------GYGLRGMRARVEQVGGTLTLTSSPAGGTTLEAVLPA---
>tr|G8SC56|G8SC56_ACTS5 Histidine kinase OX=134676 OS=Actinoplanes sp. (strain ATCC 31044 / CBS 674.73 / SE50/110). GN= PE=4 SV=1
-------------------------------------------------IVAMLIVHATVGWRAARGPGPFSIAVLGVQVALFMLAAASAPVASWLLFAV
IPLIFQLAPVRLAIGAVVLVTLVPPAVDLAAGTGNLKTDLVISAISAGSGGLWIIRVIRQSTERANLIAELEESRAEVARLSHEAGVTAERTRLAGEIHD
TLAQGFTSIITLIQASDP------ELRDERLALAVRTARENLAESRAIVAALSPSALD-AG-LTDAVRRQTARFTEETLAASFRTTGEPRD-LATPIEVV
LLRATQEALTNVRRHARANEAAVLLAYSPSSVRVVVRDDGCGFDTTTNG----------GFGLPGMRQRAEQVGGTLTVRSDPDTGTTIELEVPA---
>tr|K1DZ24|K1DZ24_9MICO Signal transduction histidine kinase OX=1210046 OS=Janibacter hoylei PVAS-1. GN=B277_06358 PE=4 SV=1
------STDPTGRWLRLGQHTLLAVLVLVCGGRSIADHPVAE-----LATLAAFVAWYAVGPRLA-RAGRGGTAWFVGLVVLWGLLVLVSPENVWLAFPL
WLLAGHVLPLLPAVLISLAVLVVVALEPVRHTGEASYAAMIGPCIGMVVALGVAQALVRDGIERQRLIASLYAAQEELARVQRAEGASSERTRLSRDIHD
GIAQGFSSIVLLARAART--EEDPQRVRELLAHLEDGATRGLEESRRVVAALAPADLD-EGSLAGAVRSVTDRFGTESVDAQVDVIGQL-PPLPTTTEVT
LLRCVQGALANVRTHARARRVVVTLDATDDTVRVDVVDDGRGFDTDAWGAAPS---GEGGYGLRATRARLREVGGGLAVESTPGEGTAVSAWAPLP--
>tr|G2NZW6|G2NZW6_STRVO Putative signal transduction histidine kinase OX=653045 OS=Streptomyces violaceusniger Tu 4113. GN=Strvi_0414 PE=4 SV=1
--------------------------------------PAGGSKYQAIALLGCVVLCYAVLDRFPGNPVVRPRVYLSVLVLALGGLAYLGSSYAMVTLPH
YWMFGRT--PRASMGFLGLATGATLAGSLVRQGFFGETLMSTLIVVAVIGLWAHSVVAQSSERA-RLIEELERTQAQLSEAHQRQGAADERERIARDIHD
TLAQGFASIIVLAEAAQAGIDHDPATSAQQLRSIESTARENLAEARELVGS-AGQGQVAAGSVARTLRRTLDRFAEDTLAVDAD---LADLECDQQTRIA
LLRCTQESLANVRKHAHASMVGVVLVRRPHGVELEITDDGTGF-------RVGE---STGFGLDGMRKRLAELGGRLTVTSSVGDGTRILAMIPVV--
>tr|D7CG38|D7CG38_STRBB Histidine kinase OX=749414 OS=Streptomyces bingchenggensis (strain BCW-1). GN= PE=4 SV=1
--------------------------------------ESSARKYGTLGLLVLVALCHIVVLTRPDNPVLGRRAYLAVLALVLGATSYFLDGVAMMSLPQ
FWLYTRA--PRDAVTLSGAAAVLAVFGGAVGQNFRTGNLVVTVVAYVALGLWVHRFIDQSNERQEQLAAELVSTQEELAAAYQRQGAAEERERLAREIHD
TLAQGFASIVVLAEAARAAADGDPERCAQQLISIEQTARENLAEARVLVGS-VPKGAVAAGSLAATLRRTLDRFTQDTLTATAE---LPDIDLDQHTRVA
LLRCMQESLANIRKHSGASTVGVLFSASPGVVELEITDDGHGF-------VVED---ARGFGLDGMRRRLAELDGELTVTSSPGEGTRVLATLPTH--
>tr|B1VNL1|B1VNL1_STRGG Putative two-component system sensor kinase OX=455632 OS=Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350). GN= PE=4 SV=1
--------------------------------------APGTTRLPVLGLLAVLALSYAAVGLFPGNPVLSPRPYLYVQVVGLGALSYLLDGGAVVTLPH
FWIYTAS--ARAAIALSGLAAAAVVTGNVVRQGFFTGNVIFTLIGYAAIGSGVRHITEDADERARRLRAELEEARLRLVEAHHRQGAADERERLAREIHD
TLAQGFASIVVLAEAARSGLATDPGTSGKHLLAIENTARENLAEARVLVGS-APQGGAATGSVADTLRRTLRRFTEDTTPVTSE---LPDVTCDQRTRIA
LLRCTQESLANIRKHAAASTVDVVLTAQPYGIELEITDDGTGF-------VTAD---SRGFGLHGMRGRLAELGGELTVTSSVGDGTRVLAMIPTD--
>tr|C7Q3P6|C7Q3P6_CATAD Histidine kinase OX=479433 OS=102108 / JCM 14897). GN= PE=4 SV=1
--------------------------------------LPAETKSWSLALLAVLGLCYAAVRFVPGNLVLRPQAFLALLAIGLGVQAYVLKGGAIISLPQ
FWILAAG--PRRAIALSGAAALACLAGGAA---FLTGNTVFTCIGYAAIGLLMNWYIRQSDERARRLSAELEETQRQLAEANRREGAAQERQRLAREIHD
TLAQGFASIIVLAEAARAGIAASPAKSSQQLLSIERTARENLAEARVLVGS-APH--VVQGSVAQSLRRTLDRFVEDTLAVSAE---LPDIECDQQTRIA
LLRCTQESLANARKHAAASTIGVVLTPHPHGIELEITDDGRGF-------VVGR---SRGFGLDGMRKRLADLGGELTVTSSPGDGTRVLAMIPTN--
>tr|D2B559|D2B559_STRRD Histidine kinase OX=479432 OS=NI 9100). GN= PE=4 SV=1
-----------AGWVR-VFHLLFYTCLTVATIVVLEG---GPD-PATLALTALMAGWYAFFVAR--RPALNPMAWHLVLIALQSALIRMDSAYETTLFGM
FALPYLLLPGRWGYAGTVML----VFSS-SAAGGHDPSVLVGNIMLATVMGLFARDLIRHSE------------------QNRVVGTLEERARLAREIHD
TLAQGFSGIIAQLEAAQQGID-DPDTVRKRISLAKQLARDSLNEARRSVDALRPEPLE-RAELHEALAAVAERWSAATVLVTVSVDGELRR-LPSEMETT
VLRAAQEALANVARHARAGRAALTLSYMDEEVTLDVLDDGTGFDPAATG---------GGYGLIAMRERASRSGGTVTVESAPGGGTALCVSIPY---
>tr|D6TIF7|D6TIF7_9CHLR Integral membrane sensor signal transduction histidine kinase OX=485913 OS=Ktedonobacter racemifer DSM 44963. GN=Krac_10757 PE=4 SV=1
----------------------------------------------------------------------------GYLIIGWALWVGLISDFS-CFVLV
LYTQVFLFPMPWKVLLALALTGLYLWCEVVSTGSWDSLIFFLSITVLCIIIAVFVAVVRQSHIRQRLFSELEATRQELAQIERQAGITEERQRLAHEIHD
TLAQGFIGIVMHLETADAVLQGETETARQHLDQARFIARENLVEARRLMWALQPEALD-RAPLSEVLGSFVACWSQESISATTLVTGQARGQRP-ERELA
LLRAAQEALTNVRKHAHASRVTVTLSYMEDMVTLDVQDNGIGFEQNERYSFPQ--EHASGFGLKGLRERVKKLQGTLAIESMPGEGTTLAVALPE---
>tr|Q1J3L3|Q1J3L3_DEIGD Periplasmic sensor signal transduction histidine kinase OX=319795 OS=Deinococcus geothermalis (strain DSM 11300). GN= PE=4 SV=1
--------------------------------------------------------------------GAEALPWAGFLTVSAAYLFSLVGSLAVLLLAV
AGTTVSLIVLSHALGFIVSVTLLFLGASL--PLR---PLVALPAVALTVWTVVFGRSVRLGEELREANAALARHAAQAE----ELAMLRERTRLARELHD
TLGHALTTITVQLEAGERLLEKNPQKARTLFERSRDLSRSATAELRASLGELRRGEMG-SL--GDELRALARSGDPDGPQVDVQVAEVS---LSPQQEHA
LARVAREALHNVRRHAGAAHVRLDLRRTPEGLVLQVTDDGLGFDPSLVP---------AHYGLSGMRERLALLGGHLTIDSQPGQGTRLTATLPLR--
>tr|F4CUI6|F4CUI6_PSEUX Histidine kinase OX=675635 OS=13855 / CB1190). GN= PE=4 SV=1
----------------------------------------------------------------------AHLGFVGVLVATSVALMCVQPGPAGMLLAV
LCVAR-LLPVRVGVPVLVVGVGLEVFETV--TGQ---Q-YVTILVLGSL-AALYGRLVAANRQAERLLAELHESRLAQA----QAAGLAERQRLAREMHD
VLAHSLSGLMLQLEGARMLVEGDPARLRATVERAHHLCRTGLDEARRAIGTLRDDDLP-G---PERLPALAEAFGDHGVACDYVETGTPQE-LGSQARLA
VYRVAQEALTNVARHAAPDRVEMRLDWTGRRVRLTVEDVGSGNAGGSGA---------AGYGLTGMRERAELLGGTLDAGPT-GHGFRVTLEVPVG--
>tr|D2PUX4|D2PUX4_KRIFD Histidine kinase OX=479435 OS=Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399). GN= PE=4 SV=1
--------------------------------------------------------------------AVLAVGFLGTFLMTSRALLSLGPALVLMLVGI
TDIAVMTFPLRRNLPLLAVGAGLVASAAW--FGR---SEFFSQLLWMAV-LVLFGRYDEVRQQTAELLEQTRLAQREHA----RAAALDERTRIARELHD
VLAHSLGALSVQLEVAEALLAERGDGALERVRRSRRLAVQGLTEARNAVATLRQDDVP-AL--PEALAALTEQHRDHGAEARFGVIGVARP-LDPGVVVA
LLGTAREALTNAARHAPGQPVEVGLEYRHAVVRLGVRNALAAGRKPSEP---------V-YGLAGMRERLALVGGTLTAGAK-GGDWVVLAEVGYE--
>tr|I0KZK6|I0KZK6_9ACTO Two-component system sensor histidine kinase OX=1150864 OS=Micromonospora lupini str. Lupac 08. GN=MILUP08_41922 PE=4 SV=1
----------------------------------------------------------------------AYVVFVGAMLVSSVTLVAVQPASVAVLVAV
LCAATGLMPVRVAVPVLIAAVVLEMVASI--TGQ---D-FGFLAVLAGF-AVLFGRLAEAQRETKRLLAELEAGQVALA----EAAGLAERQRLAREMHD
VLAHSLSGLSLQLEGARMLIAEDPTRLPAVVDRAHHLARTGLQEARRAIGMLRDDDLP-G---PDRLAALAEQFTDQAVPCDFVVSGEPRP-LESEARLA
LYRVAQEAMTNVTRHASPARVSLRLTYESTVTRLIVEDFAARPPVVPDE---------TGYGLTGMRERAELLGGTLSAGAT-AQGFRVELAVPA---
>tr|E0MU82|E0MU82_9CORY Histidine kinase OX=862512 OS=Corynebacterium accolens ATCC 49726. GN=HMPREF0277_0066 PE=4 SV=1
----------------WGLHAMFAFLLLFGVARAYIDDRLDAR---AILLAIALAAVYAAAR--------WIPLWLTGLCLLWLGLMVHAQDFMWLEFPL
IFVFLRALPKWPGLISITAWAAAAFIPAWLHPDGWSIAAAIGPLIGTTFAAGVFYRLQAEAAHHRDIAKQLQETQAELAASEHQAGRLEERERLSRDIHD
TVAQGLSSILLVSRAARNT--DDLATKNEQLAVIEDTAGENLAEARRFVRELAGPDERLETQLDSILSQMRRRTEALGTTFDLVVSG-SGS-VPSDIKQV
VVRAAQEGLNNVIKHAHASRAVVTLGLFEDAVTLDVVDNGHGVVA--PPRHR----GDSGFGLQGLSQRVESVGGSLSLESGD--GTALAIRIPLK--
>tr|I0L6F4|I0L6F4_9ACTO Two-component histidine kinase OX=1150864 OS=Micromonospora lupini str. Lupac 08. GN=MILUP08_44276 PE=4 SV=1
--------------------------------------------------------------------------------LLAVAICLIDD-LTINQVGA
SWALLEVTGRARTIWLTAGLLAAVDLTDSIGDPLRQVASGVVGLGVG---VPVLGLVIRANRELGRQTVERALAEQRRRESESRAARADERSAIARELHD
VVAHHVASMVLRVGVARHVLTDLDPRVDEVFDDVHGTGTAALAELRRLVAVLRNPDVIEPSALPSALGASVDRARQAGITVEADIDAAIGS-LDAVRGLA
VLRLTQEALTNVARHAGQARAHLTVAVHDGAVHWEVTDDGGGVSAAA---PA-----GGGHGITGMRERVEVLGGRLEAGPTGTG-WRVRTVLP----
>tr|D4YJJ1|D4YJJ1_9MICO Integral membrane sensor sensor histidine kinase OX=585530 OS=Brevibacterium mcbrellneri ATCC 49030. GN=HMPREF0183_0101 PE=4 SV=1
--------------------------------------------------------------------------------ATGFVYALTFAFPHHALITV
PVTVHAVTPRRWGKIFIGIVAAFVFAASNFTYFHVSGDATAGELLVLAALLAWTGDIHWRKRYDAQRIAERNALLERERENEIRLASDAERMRIAREMHD
IVAHSMSVIITQADGGRYAAKASPQAAVDALETIAETGREALGNLRGMLGVLRDPSST-PMPGIEDLGALVENVRAAGLEVTL-HVAPDPA-LAPAAQLA
VFRIVQEALTNTMKHGGPARAEVTVEPGELGVVARVVSTGRA-ESAA---P-------SGAGIQGMKERAHIHGGSLVAEPTET-GFLVELSLPED--
>tr|L7F618|L7F618_9ACTO Uncharacterized protein OX=698760 OS=Streptomyces turgidiscabies Car8. GN=STRTUCAR8_03055 PE=4 SV=1
--------------------------------------------------------------------------------AASVVESVTADPRAPVAMSA
VIALYTVADRTTSWRVGLLTMTVLTGSAMLAGP--LPQENLGIFA--WTGMAATGDAVRSRRAFIDAIRERAERAERTREEEARRRVAEERLRIARDLHD
VVAHHIALVNVQAGVAAHVMDKRPDQAKEALAHVREASRSALNELRATVGLLRQGDATEPAPGLHRLDELVGTFHNAGLRVEVARADQDTT-LPAAIDLA
AYRVIQEALTNVQKHAGPAKAEVSVVRVGANIEITVLDNGQA-GQKG---PE-----EGGHGLLGMRERVTAVGGDCTTGPRYGGGFRVHAILPSP--
>tr|C0ZZ40|C0ZZ40_RHOE4 Putative two-component histidine kinase OX=234621 OS=Rhodococcus erythropolis (strain PR4 / NBRC 100887). GN= PE=4 SV=1
--------------------------------------------------------------------------------VIVAVDAALGPTLPMW-LVL
SDLTYAAVTARLGRVVCSLTAVTVAALTALVYLSTQDAAAGAGVVALFFGTPVWALVIRRQVELTEAERERSRVHEALAALDREAAVAHERATMARDLHD
VIASHLSAIAIHSEAALSTSALSDDGLREMIGAIRSSSLAGLSEMRSMIELLHAGDEDSSPPRLTELPVVLDAVRAAGGTVHVAIDIDAAD-LPSVVDHT
AYRITQEALTNALKHAPGAPISMSISLQHNALQVEIRNPVGP-DTSH---PR-----AGTRGLANMRHRAELLGGSLDA--LPVDGWTVCAQLPVP--
>tr|D9TDP2|D9TDP2_MICAI Histidine kinase dimerization and phosphoacceptor region OX=644283 OS=NBRC 16125 / INA 9442). GN= PE=4 SV=1
--------------------------------------------------------------------------------LLVAALVLVDD-VMINQVGA
SWALLELTTRPRTVWLGAGLLAVVDLTSLIGEPVRAALTGLFGLAVG---LPLLGLVVRTTRELGRQAEERAEAERRRRESESRAARADERGAIARELHD
VLAHHVASMVLRVGVARHVLPDLDPRVGEVFDDVHATGTAALTDLRRLVAVLRDPDLIEPTALPAALGAAVDRARQAGVVVEADIDPAVGT-LDAVRGQA
VLRLTQEALTNVAKHAGAARAHLTVSVEDGAVHWTVTDDGRG-AAGV---PT-----GGGHGIVGMRERVEVLGGRLEAGPTGSG-WRVRTVLP----
>tr|C7MI24|C7MI24_BRAFD Signal transduction histidine kinase OX=446465 OS=Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860). GN= PE=4 SV=1
--------------------------------------------------------------------------------PLSLAEILLGGQISAY-FLL
FEALFEPVSRRLALLTTRAAIALGVLCLLAALVAGLPAVLLVAMLALMISTPLLGWEVRHHREARRAAEQLAGLEHELAATRAAHAVEAERRTIAHDLHD
VIAGHLSAVSLHTGLAASLED--PAARDRSLTTARDCAHAALRDLRSMIGVLSSAEG-ALPAVTLDWPSLTARLRWRDPQARVELDPAVAR-IEPSVQAA
LLRIAAEAVTNAVRHGEA-PLTMTVVLEDGPGAVTFTLTNRR-ATTA---AP-----GTGVGRGTIAHRAEAVGGSAGSALAREDPWQVRARLPAR--
>tr|D6X8S5|D6X8S5_STRPR Predicted protein OX=457429 OS=Streptomyces pristinaespiralis ATCC 25486. GN=SSDG_05957 PE=4 SV=1
--------------------------------------------------------------------------------ACMIGHVLNGTPGSWAAFPV
LAAVHAAARRRAGVVAGALFLAVFFAA--DTARSSEGSVERAVLLLGWFLCAGVGLIDKNWQAYLRQTEQRALEAERGREEAALRRAGEERLRIARELHD
TLTHSISIVKLQAGVAVHLARKRGEDVPAALLAIQEASGEAMRELRSTLEVLR-TE-REPAAGLVRVGELAERARAAGIPVSVTVSGEQRA-LRPDVDRA
AFRIVQEALTNVARHADRARTGIRLEYGLDDVAVTVEDDGPA-APGV---TV-----VPGTGLTGMRERVTALGGTLDTAPRPCGGFAVHARIPLD--
>tr|D9WD18|D9WD18_9ACTO Putative two component sensor kinase OX=457427 OS=Streptomyces himastatinicus ATCC 53653. GN=SSOG_04794 PE=4 SV=1
--------------------------------------------------------------------------------ACGLGQLALDVRINIVDFAM
LVIVYTVAGRRTSRLAAAICAPSLATLRWPTEHESSGEAAVSTVFIPFV-LAWVGDSIRTRRAYYAQLEERASRLEKEREAQSKVAVAAERARIARELHD
VVAHNVSVMVVQADGAAYVLDASPDQARQALETISGTGRQALAEMRRLLGVLRTGEGS-PQPDVEQIDELVEQARGSGLPVDFKVVGSPQ--LPSGVELT
AYRIVQEALTNTRKHGGPVGANVRITYFDDGLGLLVEDDGRG-AQEG---GA-----DSGHGLIGMRERVGMVGGTLDAGPRPGGGFRISALLPLK--
>tr|C9Z203|C9Z203_STRSW Putative two-component system sensor kinase OX=680198 OS=Streptomyces scabies (strain 87.22) (Streptomyces scabiei). GN= PE=4 SV=1
--------------------------------------------------------------------------------VVCLPDAGLVPTMAQA-AVW
V-VVFSQITARMRHSALALLGVSVVLDAQQHIRMMNQTPPLMALYVMTFTVPLACAVADTVRGRVQLATAQAAQAERLRELDARTAAHNERLRLARELHD
VVANRLSAVAMRITAAGHVRRLPATSESDVLDEIGEEIDSALGELRSMLGTLRSDGGTAAPPSLANVDELADSARRAGAEVEIVIKGTPVP-LPSMLDLT
AYRILQEALANVSRHARPPCATLTVDYRTDGVYLRVDDEGGH-AG-P---DA-----LPGHGIIGMRERAALCGGRATTGARPDGGWTVEAALPLP--
>tr|D1A1W0|D1A1W0_THECD Histidine kinase OX=471852 OS=NCIMB 10081). GN= PE=4 SV=1
--------------------------------------------------------------------------------PAAIADIALGPSLGTL-LIY
TDALYAAGPRRTGERLLVATAAVTVLLAGAALPLAADAAVIVGGVGMTFVSPVLAMVVRGHRDRAELERQRAEQLARLAELDRRNAVAAERARMARELHD
VVAGHLSAVALHSAALLRLPDMDRDSVHRAMTVIRENSVQGLAEMRRMIGLLREGREDPAAPRLADLEQLAERAARPDLTVGLKVTGTVRE-LPAAVELA
AYRIVQESLTNALKHAGPGRAEVLIEHHPQRLCITVDSPLGA-QRTE---LP-----GAGSGLIGMRERASILGGTFQA--GPDAGWRVRAELPTA--
>tr|F4F3S0|F4F3S0_VERMA Integral membrane sensor signal transduction histidine kinase OX=263358 OS=Verrucosispora maris (strain AB-18-032). GN= PE=4 SV=1
--------------------------------------------------------------------------------LLAVAIPLLDD-ITINQVGA
SWALLELTEATRTIWLTAAGLAAVALTDSIGEPLPRFLAGVVGLLVG---VPLLGLVVRTTRELTTQAQQRAAEEQRRRESEARAARADERSAIARELHD
VVAHHVASMVLRVGVARHVITDLDPRVDAVFGDVHATGTAALADLRRLVAVLRDPDVIEPSALPAALGAAVDRARQAGITVEADIDPAIGA-IDAVRGLA
VLRLTQEALTNVARHAGPAVARLTVRMRDGAVHWEVVDDGRG-PVPV---PA-----GGGHGIPGMRERVEVLGGRLAAGPVGTG-WRVQTVLP----
>tr|D9TC94|D9TC94_MICAI Histidine kinase dimerization and phosphoacceptor region OX=644283 OS=NBRC 16125 / INA 9442). GN= PE=4 SV=1
--------------------------------------------------------------------------------VVILGYYALDLPPVGVAAPA
AAVLYRVSRVVPAAVVAGSLLAVSVVARLAEGDDIAV-VVGTELGAALLLAVIAGDAVRNRRSLRAALVRQAVAADEERHREAARQVEAERLRIAREVHD
TLGHTMSVITLQSAVAREALDSDPAQAESALAAIRSVSGSAMAELRATLGTLR-REPREPAPGFDRLPALVDGVRRGGLTVDLRIEGPVDT-LPAVVGST
VYRVVQEALTNVLRHAEATRVTVTVRATPGRLALEVVDDGRG-GPPA---GR-----RGGQGLRGMAERVALLGGTVEAATGTGGGFRVSVYLPLG--
>tr|D6EEZ3|D6EEZ3_STRLI Two-component sensor kinase OX=457428 OS=Streptomyces lividans TK24. GN=SSPG_07178 PE=4 SV=1
--------------------------------------------------------------------------------ACAAASVALGYLISPLLLPV
LIALYELAPQRTAYACYGATVALVVPAALLSARDGRPDESVGPVF--WILLPVLGTAVRNRRAHLDAVHTRAEHAERTREEEARHRVAEERIRIARELHD
VVAHHMALANAQASTAAHLARTHPEQAHEILAHLTGTTASALRELKATVGLLRTGDGDDPPPGLGRLPELVSAFGSAGLHVTVTVRGTRRP-LPPGVDLT
AFRIVQEALTNVTKHTDAGTADVHLAYAHDRLTLTVTDDGGA-SPRP---PG-----PGGFGLVGMRERAETSGGGLSAGTLADGGFAVTAELPAP--
>tr|C1B303|C1B303_RHOOB Putative two-component histidine kinase OX=632772 OS=Rhodococcus opacus (strain B4). GN= PE=4 SV=1
--------------------------------------------------------------------------------AVTVLYVARGYGYGPVFLSL
VVAFLSAASR---WRTYVLAVGYVLIVFAVPAV----SDAEAPSLIAWLLVLLAAEIIRQRRGTLDARRQRAEAAERAALDEQRRRASEERLAIARELHD
VLAHSLSLINVQASVALELWDSRPEQSQEALSAIKVASRDAIGDVHALLASLRGNDSTAPTAGIGDLDGVVERARTAGLAVTTVVEGTPRS-LPAVVDVA
AARIVQESLTNVARHSGGSPAVVTVTYTPTSVRIRIDDDGRG-PDSA---PT-----VGGNGIPGMRERARALGGELTAGSGPGGGFRVQATLPHD--
>tr|I0L6X4|I0L6X4_9ACTO Two-component system sensor kinase OX=1150864 OS=Micromonospora lupini str. Lupac 08. GN=MILUP08_44446 PE=4 SV=1
--------------------------------------------------------------------------------AAMLALHIRVHSGVSAAFPV
LGVVYVAARRAAAAAASLAFLGGFLARDVSVAPVDRPNAERTALLLGWFVAANVGLVGRQRRAYLEQVEQRAIEAERTREEMALRRAGEERLRIARDLHD
SLTHSISVIKVQAGIAVHLARKHGDEPSATLLAIQEASSAAMRELRTTLDVLR-AP-DDDRVGLARVDELAERTRAVGVPVQVTVTGRPRH-LPDDVDQA
GYRVIQEALTNVARHAGPATAHVHVEYAPAGLTVAVTDDGQA-SQAR---PP-----TPGVGLRGMRERVTGLGGTLHAAARDGHGFGVRATFPLD--
>tr|H0BR99|H0BR99_9ACTO Two-component system sensor kinase OX=1055352 OS=Streptomyces sp. W007. GN=SPW_7787 PE=4 SV=1
--------------------------------------------------------------------------------LCLFGYVVLAQPGSWAAFPV
VVAVHAAAHRAYGIGAGAAFLAGYAGVLFVSGPGAGETVERALLLLGWFLCAGVGLIDKNWQAYLHQTEQRASDAERTREETALRRAGEERLRIARELHD
SLTHSISIVKLQAGVAVHLAHKRGVAVDPALLAIQEAGGEAMRELRATLEVLR-TDELSPGAGLARIGELTERARAAGIALSVRTDGDART-LPEDVDRT
AYRIVQEALTNVARHAGRARTVVRIGYTERILTVAVLDEGPC-APGS---AI-----TPGTGLTGMRERVAALGGTLVAAPRPDGGFAVHAELPLA--
>tr|E8WEK1|E8WEK1_STRFA Integral membrane sensor signal transduction histidine kinase OX=591167 OS=Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD). GN= PE=4 SV=1
--------------------------------------------------------------------------------LCMFGYAVHAHPGSWVALPV
VVAVHAAAYRAQAAGVGAVFLVAYSVVLLVSVPGIQDTVERVLLLAGWFLCAGVGLIDKNWQAYLRQTEQRALDAERTREEAALRRAGEERLRIARELHD
SLTHSISIVKLQAGVAVHLARKRGAEVEPALLAIQEASGEAMRELRSTLEVLR-TD-VDPRTGLARMDELAGRARAAGIELTVHVEGDVRR-LPAEVDGA
AYRIVQEALTNVARHADRAGTSVRLTYADTALVVLVDDDGPC-LPGD---RV-----TPGTGLTGMRERVTALGGTLDAAPAARGGFSVRAELPLA--
>tr|D7B147|D7B147_NOCDD Integral membrane sensor signal transduction histidine kinase OX=446468 OS=JCM 7437 / NCTC 10488) (Actinomadura dassonvillei). GN= PE=4 SV=1
--------------------------------------------------------------------------------VLVVANYVLQLPVIGLAVPV
AAALYSAARTLWSVGLAAALVLVSTFTRLQQGQDPAY-LLGYELPVAVMGAATAGHVQWQRRRAEHQRVRIEVLDRQARESEAAERQALERTRIARDLHD
AVGHHLSVVSLHAGVAAEALDDDPADARAELDHVARASRAGLSELRATVRALR-EADGDRVSSLAHLDELVATVRAAGVDVEVTGVPAPGE-VPGMVDAT
AYRIVQEALTNTLRHARAPRARVAFSRRDGMLDVTVTDEGTA-VPVA---SP-----G-GSGLAGMRERVRLVGGSVEAAPRPGGGFGVRALLPLG--
>tr|D3Q6W0|D3Q6W0_STANL Histidine kinase OX=446470 OS=102104 / LLR-40K-21). GN= PE=4 SV=1
--------------------------------------------------------------------------------AAVAVYSQFNTMSMLGSVPL
LAAVFNSMHRWFSVTLVAPVIVVLTTINLIEEPDRPLRPEASGIPLGWVVAAGVGEVFRQYRAYVDQAEQRAIEAERGREEMALRRAGEERLRIARELHD
SLTHAISVIKMQSSVAVHLAAKQGQRPSEALTAIQQASIEANRELRSTLKVLR-DD-QPPEPGLHRLSELVEQIRLAGVRATVTVEGERGA-VPTEVDWT
AFRIVQESLTNVARHAGAETAQVLLRYSPGALEVNVTDDGRA-DPSM---PP-----VPGVGLTGMNERVAGIGGRLRAGPKPGGGFAVSAVLPLG--
>tr|D2B1S2|D2B1S2_STRRD Histidine kinase OX=479432 OS=NI 9100). GN= PE=4 SV=1
--------------------------------------------------------------------------------ACMLVVAAHIQPGPPAAFPV
LVSVFGAVHRLAPALAGVLFLGVDLVAHLPGADGSGQNLHSAALLVGWFVAAGVATMIRHRQAYLEEAEQRAAEAERTREEAALRRAGEERLRIARELHD
SLTHSISVIKVQAGVAVHLARKRGEDVPPALLAIQEASGDAMRELRATLEVLR-DSSEVPASGLDRLDDLVERARSTGLPATVTISGTRRE-LSAEVDRA
AYRIVQEALTNVSRHAGGAAAAVRIDYADEELVVQVDDDGKA-DPDA---PP-----VPGTGLLGMRERVASLGGRLRAEPRPTGGFTVRAELPLG--
>tr|J7LXC1|J7LXC1_9MICC Putative sensor histidine kinase OX=1118963 OS=Arthrobacter sp. Rue61a. GN=ARUE_c26540 PE=4 SV=1
--------------------------------------------------------------------------------LVCLVQWAVAAEPVAGQIAV
PLVIYATAPAWASRTVAGLLGGVMLTTRLFSTTAESGGLTIGALYLIWMLVSWTGDLTRVRRLQLQALEDRTRRLEVEQMQERKLAAADERSHIAREMHD
IVAHSLSVIITQADGARYAAAAKPELATEALATIAATGRDSLGEMRRLLGVLRSDDSR-PQPRLSDLDELLLGFRAATLQVTFEQSGAPRA-LPAGAELT
AYRIIQEALTNVMKHAGPATAAVTLAWQARGLQVDVVDDGRG-AAAP---PT-----AGGNGLRGMGERVSLYDGSLTAGPEQGGGFRVSAFIPYS--
>tr|D0WKH2|D0WKH2_9ACTO Sensor histidine kinase OX=649743 OS=Actinomyces sp. oral taxon 848 str. F0332. GN=HMPREF0972_00273 PE=4 SV=1
---------------------------------------------------------------------------FAAVTVVSVWGAALADRNAIYAIPE
LFIALA---YRRALAVAAVMNFGLVAVQ-ALGGEPTPDN-LSKWAVAAVATVVLTLLAETNMRNQELVEQLQARNAQIARLSHLEGTARERERIAREMHD
TIAQGLASILALARAAAAEVAQGPRQASRHLAMIVELAQEGLDDTRRMIADASPRALD-GRGLAEAVGRAADRLEREGIAVARSLDSTLPP-LPQPARVA
ILRIAQEAIANVARHSRAANVAVSLRSVAGVAVLEVRDDGVGFDPATAGAVPGRAPDDSGFGIPDMRGRAADLGGSVSIDSSPGSGTRVLARIPVE--
>tr|B5JFN8|B5JFN8_9BACT Histidine kinase domain protein OX=382464 OS=Verrucomicrobiae bacterium DG1235. GN=VDG1235_3284 PE=4 SV=1
----------------------------------------------ILQLILWAAFAWVFQGYFGVDRSSLRARWREIVLVFGPLCFAYTGYFGVLMFVL
AGFSTLVFPVWLAL---VYLVYQT-IVWI-FLSRFMWGWMQIDTMFSGLFSSMMFYIFRRERESRALTLDLDEANEKLSGQIEELAATQERNRIAREIHD
TIGHSLTVVNMQLETSKALIDSDKEKAKRFLEKAQEVTRQGLTDVRSSVASLRSSPLD-GKSLPGALEGMMSASFGGGVKTRFELKGEVAA-LNPASEAA
LYRSAQEALTNVRKHADASEVKLSLDFFPECVKLVVADNGKGSE------K-----VEGGFGIMGIRERIQLLDGEMRVSTSPGQGLELSLSLPR---
>tr|K2C541|K2C541_9BACT Histidine kinase protein OX=77133 OS=uncultured bacterium. GN= PE=4 SV=1
----------------------------------------------LITVIILLGIAYITNGIYGSRKGTMSTKIIYFALILGGLIVYYGRGAGLILLPL
VAHTAMLLDDWMLAAVGIILTFIL-AVYL-YSSRLVIVWASVPVFFAGVFILIFTQMAVTEQRARNLAAELSEANKHLADRVRELTITQERNRMAREIHD
GLGHYLTTINMQIKAARAILTKDNKKALSLMENAQNLSSVALVDVRNSVFALRQDPEE-MPPLFQRIAEITKSASTTNRKIELIIKGEPRP-VNAQQDLT
LFRAAQETINNANKHSNATSVKLTLDYDPNRIGLESVDDGIGSD------E-----INHGFGLIGIQERVRLLNGETQIVTSSGKGFKIKINIPS---
>tr|B1ZUT3|B1ZUT3_OPITP Integral membrane sensor signal transduction histidine kinase OX=452637 OS=Opitutus terrae (strain DSM 11246 / PB90-1). GN= PE=4 SV=1
----------------------------------------------W--LVFALGALYAILGVLG----RWR----YVVTALATAIVFVTPLKGLVTMPA
ASLVVLELSPWAT-LLELF------------------ALTSAPSYGIAVFVVVFSLVTRQARESRQLSQELAAANEQLAAEAGELATTRERNRIAREIHD
GIGHYLTTINVQLEAARAVFTAQPAQAATALDQAARLSREALEDVRRSVGTLRADST-R-PPLPETLRAL----ANLGLNATVRVQGAPRT-LPANVEHA
LFRSAQEGLTNVCKHAAATAIDVALDFQEQRIALTLADDGQG-G------H-----PTKGHGLQGLRERVELLGGMVRFGNRPEGGFTLRVELPT---
>tr|E8N566|E8N566_ANATU Two-component sensor histidine kinase OX=926569 OS=UNI-1). GN= PE=4 SV=1
----------------------------------------------WLTLMILLGIGYLTTGVYGAHDDRLLIRVGYFLIPLGALSIILSGQVGIILLPL
VGHSVFLLPAWKYLILLIVFSYGA-IVHL-MTASWEFVWASVPVFGAGVFILVFTQMMLNEEKARSLVVQLREANDRLAIQAEELAIVKERNRLAREIHD
GLGHYLTTLNMQIKAASAVLETDLEAARQLLAKAEGVTHKALLDIRQSVRALRDPSLP-VKSVEEILAGLLEECEHSGIHTLMEVKGEPRK-VDQELKAS
IIRLVQESISNTLKHSKATLYQLVLDYQSDCIILEMKDNGVGGE------I-----SAVGFGLLGMQERVALLKGKMEIATTNGAGFSIKIILPG---
>tr|C7QGR8|C7QGR8_CATAD Histidine kinase OX=479433 OS=102108 / JCM 14897). GN= PE=4 SV=1
--------------------------------------------------------------------------MLGVCSLAVAVHLALVPTVVDLSAVL
LATVAARCPRRVSAVALGGMLVLMAGWCFDGARLWSAVALLGSVLLAAWAGSANGSRRDYLHQLHARAADLERERDQQAAL----AVAAERGRISREMHD
VVAHGLSLIVIQAQGADAALDNRPADTRSALRAIVRTGRDSLADMRRVLAALGEVEDAPQPGLAQ-LPGLLEQVRTAGTAVRLRVAGTPAA-LPSAVDLS
AYRIVQEALTNVMKHAGGASADVVVEYSDTEIAVEVGDDGRIPN-GHG---P-----GVGNGLRGMDRRVQLLGGRLSAEPEAGGGFRVRATLPI---
>tr|C5BWN4|C5BWN4_BEUC1 Histidine kinase OX=471853 OS=Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432). GN= PE=4 SV=1
--------------------------------------------------------------------------AFAAAMVAAVAQMALGAVPADLAVPT
LYTVAAHRSRRVSLPLLGAALAVVVAWSVFVAVDWGGILLLAPTVGVAWAGWGARSRRAYLGELEARARDAERESDQQAAL----AVAAERARLTREMHD
VVAHGLAVIVMQAQGGAAAFDRRPADTLAALEAIVATGRASLADMRQALGTSAQLHDAPAPGLAE-LPRLVDRVRRSGTPVRLHVDGEPRP-LPAGVDVA
SYRILQESLTNTMKHAGGAAAQVLVCFDHDVLVLEISDNGAGGT-SVV---A-----GGGNGLRGMRERAGLLRGEVTAGPGTDGGYVVRARLPL---
>tr|I0H569|I0H569_ACTM4 Putative two-component system sensor kinase OX=512565 OS=/ JCM 3121 / NCIMB 12654 / NBRC 102363 / 431). GN= PE=4 SV=1
--------------------------------------------------------------------------LLAVCCAAAVIPLAGPLTIINLSVPL
LYTVAVRHGWARSLAVLAALLVLAVGSSTFAVREWNDLPGLILILVAAWAGSGTRSRRAYLAELRARAVDRERERGQQAVL----AVAAERGRISRELHD
VVAHGLSVMVIQAQGGAAALDNRPADTRAALEAIIKTGRDSLADMRRVLSTVGEVDDAPQPGLAM-LPALVDQVRTTGTPVGLRVEGTAVP-VPSAVDLS
AYRIVQEALTNTMKHAGGAGADVVVAYATGSVEITVSDDGSVP----A---H-----HDGTGLRGMRERVRLLGGRFDAGPGPQGGFVVRAVLPV---
>tr|E3IZ02|E3IZ02_FRASU Integral membrane sensor signal transduction histidine kinase OX=298654 OS=Frankia sp. (strain EuI1c). GN= PE=4 SV=1
--------------------------------------------------------------------------MFLLCVLAAAARLAAPPTVVDLAVPL
LATVAARYPRSVSLPVLGGLLLLGTVWLTYGTLTWGAPSVLGSVLIAAWAGAGDRNRRAYLAQLQARAQDLRRERDQRAAL----AVAAERGRISREVHD
VVAHGLALIVVQAQGGEAALDSHPAATRSALRTIVTTGRDSLADMRRVLTAFDDLEHAPPPGLTQ-LPGLLTRVRAAGTPVRLRVEGTATM-LPSAVDLS
AYRIVQEALTNVVKHAGGASAEVVVSYRDTEVGIEVSDDGE------G---T-----VAGNGLRGMRRRVTLLSGDLEAGPGDKGGFVVRAALPV---
>tr|B5H912|B5H912_STRPR Two-component system sensor kinase OX=457429 OS=Streptomyces pristinaespiralis ATCC 25486. GN=SSDG_01551 PE=4 SV=1
--------------------------------------------------------------------------VLAVTGLCAVGYQAADVPA--VAYLA
VYAAVRAGHRTLTVVASVVMLASLPLAGLVSGLS-GEAFQARGALEIAWLAA-GAA-GEALRQAERRADEAERTREETARR----RADEERLHIARELHD
SLTHQISIIKVQAEVAVHVARRRGEQVPEALLAIQEAGREATRELRATLEALRDDDTTP--GLDH-VKELVERARSTGLDATLTIEG-PRPDVPAAVDRT
VYRIVQESLTNIARHACAGTASVRIDCRPDALKIRIDDDGKAAP-GSA---P-----VPGVGLLGMRERVTALGGRLRAEPRGEGGFTVQAELPV---
>tr|E3J3V8|E3J3V8_FRASU Integral membrane sensor signal transduction histidine kinase OX=298654 OS=Frankia sp. (strain EuI1c). GN= PE=4 SV=1
---------------VLGLHLAFVVLVTLATVTVLTVDEQAAWRPAGLASLGAITVAYAVVRFRTRRQTRVVTAYLVVLVLGIGVLARVAPDGLFIAYPQ
VWS-LEERRAPSVVWTVLVFVASLAGVLLHQEQHLGLVAAIGNVAFSLIGFWVH-RLFDRNRDQAGLIAELGRTKAEVAALERDRGAQAERERLARDVHD
TLAQGYTSILMLARTALAQLGTDPAGARERLQLVEEVAQENLAQARALVAAQSRVELD-GTSLRDALTQLARRFTRETIDVDVRVAGEPTDPLPAAQELV
LLRAAQEALTNARRHASPSRVSLVLAGGPGEAILRVVDDGVGFAAGT----------EPGTGLTGLRRRVEAAGGELRVTSAPGTGTEVLARL-----
>tr|G6HJJ6|G6HJJ6_9ACTO Integral membrane sensor signal transduction histidine kinase OX=298655 OS=Frankia sp. CN3. GN=FrCN3DRAFT_6331 PE=4 SV=1
---------------LVGLHGSFVILAALAVLTILTNDLSEPWRPAALAAIGAIVLAYAVARVVSPRGRALIVVYLVVLVAGIGVLARTDPDTLFIVYAQ
VWS-LVDRPLPGTFWSLALVTASIVGMALRPARRPDLVSLIANVAFALMGIWVH-SLFDRSREQARLIEKLESARAEVAALERERGAQAERDRMARDVHD
TLAQGYTSILMLARTAIAQLGADPAAARERLELVEEVASENLAQARALVAAQSPVELD-GTSLRDALTQLAGRFTRETIEVDIRFTPEPTGNDGDAEELM
LLRAAQEALTNARRHASPSGVTVALDARPGEATLRVVDDGVGFAVGT----------ETGSGLVGMRRRVEEAGGELLVTSAPGAGTQVVARV-----
>tr|E4ADD2|E4ADD2_PROAA Histidine kinase OX=765124 OS=Propionibacterium acnes HL037PA3. GN=HMPREF9622_00812 PE=4 SV=1
---------------QIGIHVLFASLAIFTIAMALVLS--PPHLGRVLVWAVLLIVVYTIGTHVMDRSRRKSRPFLVAMIVVSILLAIDFPYAAYLTIPL
SFVYLDHLPLQACVGVVVAVAVVV---GVGLTSGWSVGGIVGPVAGAAVAVFVLKAMQAQASELERLNVDLLAVQKRLAASQHQAGVLEERARLAREIHD
TVAQSLSSIGLLLSAVERTDPEHP--AVEQIQLAHRTSLEALSETRGLIAELAPPTIT-HQGLPAVLERLGATWSIGGLHVD--VD-CPDTSLPMEIQTA
LLRLCQGAMSNVVRHADASHASIRIRPSPERVLLRVSDDGGGMVLEAPVS-------DGSFGLQAIRQRVEDLSGEVSLTSRPGEGTIVDVGLPVP--
>tr|E1VZP3|E1VZP3_ARTAR Putative signal transduction histidine kinase OX=861360 OS=Re117). GN= PE=4 SV=1
------------GWLVAGVWVIF---LVFPIMDLLVEYPLSTR-IIGLGMVALFAGVYLQSYSGRGTSTRAHVNFLILCVIILVGIPVTGL--TAMGFPF
ITYAAFLLTRKWLIGTYAIVLVL----SFALPLAFGRFLDA---IFLILNAITVAAISRSA-SAEKIRS--------------DYLLVAEQERVARDVHD
GIGHSLTALNLKAQLALRLLDEEDGQVRGELEQLSALAVNALDSVRTTVQGLSRQDLAAE--LAELQQACTDN----N--LEFTVAGTAEQ-IPLTLRSH
IAWILREAVTNVLRHAHASTVVIHIGS----TRVSVDDDGDGLQPN-----------AVGHGIRGMQERARQASCSVGASRLG--GTSVQVVFA----
>tr|H5THN6|H5THN6_9ACTO Putative two-component histidine kinase OX=1108044 OS=Gordonia otitidis NBRC 100426. GN=GOOTI_036_00050 PE=4 SV=1
------------RWVFTAVWMIF---LAYPITAVVTSHSTVTK-TIGLTILTVFACGYLWASVTGRNATDRGIPFVLLTCLMVALLPIINE--NAFGAPF
LMVAAFCFP--TRWALLCIGALV--VSSVALPRLFGWSTDASIVLVLLVGIIREGEREREEERRRELDA--------------RLAIVAERERVARDVHD
ILGHSLTVISVKTELAQRLVELDPPRAQRELGEINQLTRDALAQVRATVGRMRTPDLPDT--IAGADSALRAA----G--IEATLPEPTVA-T-D-HAEL
FAWVLRETVTNVVRHSGARHCDVRIDA----SSISVHDDGRGLGDA-----------EHGNGLRGLRERVESAGGTVLFDSDS-TGMTVRVQIS----
>tr|E0MXR2|E0MXR2_9CORY Two component system sensor kinase OX=862512 OS=Corynebacterium accolens ATCC 49726. GN= PE=4 SV=1
------------NAVFASVWLIF---LLFSLILNFVQGVDATQ-RLSTACVIAFSALYFFSFGYYPRGWNRAARWSALALIALIAIPFFGV--YATTVPY
LAFLGFQLPLRRAL-----LWVL--LTGLVVTGAL-WSVDSGTFIVIFWP-VMLGTMSQREDSRTDLEH--------------QLDLARQREDIATDVHD
LLGHSLTVINLKSELAQRLVDVDPTRARNELQEISDLSRKSLAEVRSTVTRMRMPTFEGE--VQAARRAFDTT----G--IQAHLPANVQA-V-GLYDAA
FSWALRELTTNVIRHSGAQNCWVSITQ----NKLQVVDDGCGFDPK-----------KQSGGLHGLHKRMKDSGGKLIINGDT-ELLPLDSEVE----
>tr|I7LB38|I7LB38_9ACTN Uncharacterized protein OX=883169 OS=Turicella otitidis ATCC 51513. GN=BN46_0036 PE=4 SV=1
------------RALYSVIWVVF---LLTPLTLAATSAHPGWV-ALAVGATIAFGAAYVAGIAAEPRG---AAACLALAALAAATIPAIGPG-GALTTPY
FSLVAFGLPARRGIPAAIALWALP-ATGYVAAGGIVWHA--GP-----IG-IVVIRLAEAAESRAAVEE--------------QKRLAEDRERVARDVHD
LLGHSLTVVSLKAQLASRLVEADPQRARAELDEIYSLSRDALHEIRETVTRLREPTLESE--AAAARRALAAA----G--IDADVDVSPGG---GERDDL
LAWALREAVTNVIRHSRATRCTVSAAG----GSLTVADDGVGIDER-----------SRPGGIAGLKERAAAHRARLSVPGTT-PEQP-GTRIE----
>tr|L7LMH9|L7LMH9_9ACTO Putative two-component histidine kinase OX=1223544 OS=Gordonia sihwensis NBRC 108236. GN=GSI01S_28_00380 PE=4 SV=1
------------RWLFAAVWLLF---MGYPIAGIITAARWLMK-ALALAIIAVFVVVYLLLCVFDPRSAPRNAAIALLAVLMIGLMPLLRA--DAFSAPF
VMAVAFAAPWRVGYSLAGVAAVL--VSAVVVPELFGWELDSGFLIVLLVGVMRDGERDRELERQRELNG--------------QLAVVAERERVARDVHD
ILGHSLTVISVKSELAGRLVDLDPARAKQEMAELNALARQALAEVRSTVGNLRAPELPSV--VAAAEIALTAA----E--IDADLPDPDAY-D-GPHAAL
FAWVLRESVTNVVRHSGATRCVVTLTD----HSLTVADNGHGSPLL-----------TFGNGLRGLAERVDAGGGRLTVDSDA-TGTTVTASVD----
>tr|I4EUY2|I4EUY2_MODMB Two component signal transduction histidine kinase OX=1144889 OS=Modestobacter marinus (strain BC501). GN= PE=4 SV=1
------------QAIWALPWLLF---QYFPISDLVTTRPAAAR-WVGAVGLLAFTLVY-----RAGQLGRRRADFVVMVGLAAALAVGFGA--DWSGMIY
VSAAAAALPWRWVWPAVVAAALL--CLVVILADEDSGLLFLPPICLLTFGTGYLMTVNRELQEAREELA--------------RSAVAEERMRFARDLHD
LLGHSLSLIALKSELARRLAEVDPPRARQEMADVEEAARRALAEVRDAVSGYRQVSCAQA--LAEARAALTGA----G--VAVRLPDVVPV-LPGGVDAA
LGWVVREATTNVLRHSGAARVTVELTEDGVRAVLTVTDDGAGTGERLTV------LGGSGAGLAGLRERVAALGGELAAGPVD-GGAEVPLLPA----
>tr|D7BKW0|D7BKW0_ARCHD Integral membrane sensor signal transduction histidine kinase OX=644284 OS=15585 / NCTC 8452 / 11018). GN= PE=4 SV=1
------------GLFMSLIWLAF---LAFPTYYIATGYSTTLK-ITGFILTTIFCIVYAIGCSREDKKEERAATAIPLLGITFIILKLFNI--SGLSFPY
LFLAGMLLEFRYAISVVFT---L--STIIELAGWWQNHLAEAHSFLLVLGTRYFDHAERE---KRALSA--------------REAVASERDRLARDVHD
VLGHSLTILALKSELALRVFDSDPQRARSELEAISSLTRSAIAEVRATVSGLRMQLLTEE--LDNSLRVIRDS----G--LTVTVDGEPDA-VDPRFRFV
FAWVVREASTNILRHARASHVTIVLRS----GIVSVEDNGIGISNV------------PGNGLLGLRERVENAGGQLQIEPTH-PGTRISALMD----
>tr|F1YP75|F1YP75_9ACTO Signal transduction histidine kinase OX=644548 OS=Gordonia neofelifaecis NRRL B-59395. GN=SCNU_18622 PE=4 SV=1
--------------MFAAVWLIF---IVYPVVAVITSSSAAVK-AIGLALLALFVVVYLLLCVFDDGSVARNTAIAALAALMVGLMPILHT--DAFAAPF
LMAVSFAAPWKPRYSLAAVVAII--AAAVVVPEIVGWELDTGFLIVMVVGVMRDSQREREEERQRELNA--------------RLAVVAERERVARDVHD
ILGHSLTVISVKSELAGRLVDLDPDRAKTELAELNALAREALAEVRATVGNLRAPELPSV--VAAAEIALTTA----G--IDADLPDPDSC-D-GVHAEL
FAWVLREAVTNVVRHSGATRCTVTLTA----ESISIADNGRGSPLL-----------TFGNGLRGLAERVDAGGGRLVVDSDA-TGTTVTATVG----
>tr|D4YKQ8|D4YKQ8_9MICO Possible two component histidine kinase OX=585530 OS=Brevibacterium mcbrellneri ATCC 49030. GN=HMPREF0183_0518 PE=4 SV=1
------------N-MYGLIWLVF---LIIPLV-LVWTHPVAVK-VLGTCGTVLFGVVY----CVSQKPFDVKIRHVVLLIPVCLTIPSLGV--AVTSAPY
FALGVFGLSFVAALCWSTATLFF----TVAVPLIFSPQSFL---MSVAPALVKFIEV-REV-AEQKMKN--------------ELDLVKEREAISRDVHD
MLGHTLTVVSLKSQLALKTVHTDPARCEAELRELMTLNQRALEDVRTTVGRLRTPDLATQ--VDEAENAMRAA----G--VHVTRQGDWAT-WDPERRAV
VAWAVREASTNIIRHANATSCTLAFDD----NGVTVTDNGNGLEGS-----------REGHGLTGLRRRVDEAGGTVTLSDMG-DGTELRVEFA----
>tr|L1MAI9|L1MAI9_9CORY Histidine kinase OX=1035195 OS=Corynebacterium durum F0235. GN=HMPREF9997_02350 PE=4 SV=1
------------RYVLAGVWLIF---LTLFITDVSKSHSAVIK-TTSYALTALFIAVYLLSMMHPRIRIDVAWVVVLLAIVTIGWLTRLPS--TA-TVPY
IIVILYKLEWR-----MVIPTTI--TLLIALPLLIVGLINDDYGPITLIV-IIAGRYGVEVFVRRDVEQ--------------QLAIVQERERVARDVHD
VLGHSLTVINLKSELARKLIDHDPEQARREIEAVAELSRSALGEARATVTHLRTPDLARE--LVSAAEALATA----S--IRATVPAPHHA-TIDDTSRV
FAWALKEAVTNVIRHSGATHCVVELAP----SRLVVRDDGRGFRST-----------HRGNGLGGLEARVAESGGTLTITSDS-SGTELNITMD----
>tr|G2GIJ9|G2GIJ9_9ACTO Two component sensor kinase OX=700597 OS=Streptomyces zinciresistens K42. GN=SZN_26696 PE=4 SV=1
-----------------------------------------------------------FAALLVRRRYPLTVLGCVLVI----AG-NNVWAMVVVPCLV
WSAARRVTPVRAWAVAGTGGAGAVLL-SVAAQ--FPGGPYLAAGVAALFLPALSGVMMGR---RRPLTRLLREYLEQTRFLTEEAARSEERTRIAAEMHD
LLGHRISLLSMHAGALQLAAERQAPALAAQAELLHTTAGTAMDELRGILGVLRHRSGEERGTRE-DLSALVEDSRNAGADAELHWN-APES-VDAHARTA
VHRVVREGLTNALKHASGAPVRVTFQDDGDSVVVAVANG------APPVPCP-----PGRSGLVGLHERVGLLGGVLHAGPRPDGGFLLSARIPVR--
>tr|F5XQW2|F5XQW2_MICPN Two-component system histidine kinase OX=1032480 OS=NBRC 101784 / NCIMB 13414 / VKM Ac-1990 / NM-1). GN= PE=4 SV=1
-----------------------------------------------------------TSSLLVRRSHPVALAWATTASLLQVLP-TPTLSIVVVPMIV
YAVTRNASPRTGLVALWIGLAGAVIG-PAR----WSGLIAFAVTACAAIGAYLLGRQLREQQNRRQRAQAELELQQSEQEQRARAVAIDERSRIARELHD
IVAHSLSVIVVQAEGGRAVVLKRPEVGAEVLDTIAETGRTSLAEMRRIVDVLRGGSAELSPGLG-DLAELVAR---SGDRFQLLVRGTTPA-VPAAIGLT
VYRVVQESITNVLKHAPAATAQIRIDYLPASIEIEVSDDGRG---AAAHAAP-----EPGHGLRGMAERVSLMHGRLDARPRPGGGFVVRASIPLP--
>tr|C6WLG1|C6WLG1_ACTMD Histidine kinase OX=446462 OS=3971). GN= PE=4 SV=1
-----------------------------------------------------------LGTVLLRRRRPAVLAVATVITAIGVAR-WPAPSGLFLLLSV
YSAALHSRHRHACLAWGATALAGFAA-GPAQW--WSP-EQFS---LFACGGAGIGDSVRM---RHAYVAEVTEQAEETREQEARRRVLDERLRIARELHD
VVAHHIAVISVHAGAAGHVLRDRPDQVWPVLGHIRGAADAVLDEVKSVIGVLRDPDEAQTPGLD-HLPALLAGLEAAGFSVRREESGAPRR-LPSVVDLA
AYRIAQEALTNAHKHG-DGSAELTITRTPEGITVEVVNR-IG---PGRAGGP-----GSGFGLIGMGERASATGGSLTSGRLPGGRFRVRAELPAP--
>tr|D2PPC0|D2PPC0_KRIFD Histidine kinase OX=479435 OS=Kribbella flavida (strain DSM 17836 / JCM 10339 / NBRC 14399). GN= PE=4 SV=1
-----------------------------------------------------------LGPLVWRRKYPLVFFGVSGVAVLQWAG-VDLVGNIGLLVAL
YTISVYGEVRYSRIALGVGGLGVLMA-TARYYADWRQQVAFG---AVVFGVWAFGERRRT---RGLYVAQLEEQLERDRDREAALAVSNERTRIAREIHD
VVAHGLSIMIVQADGGLYAADASPEQAKKALATIGDTGRASLTEMRKMLGLLKQDEQNPQPGVD-SLPELIENVREAGLSVDYQVTGTPRD-LPALLGLT
AYRIVQEGLTNTLKHAPGAHACVTLHFGREMLTVVVTDDGRG---AGVASSS-----DPGHGLVGMRQRASISGGTVSAGPKAGGGYEVVAKLPYD--
>tr|C8X891|C8X891_NAKMY Histidine kinase OX=479431 OS=Y-104) (Microsphaera multipartita). GN= PE=4 SV=1
-----------------------------------------------------------LLPLIFRRTAPTVFAVIVVVAGLQWLG-LPLAADVGVLIAL
YTVATRFALRTAVLAGGVVEIGALLA-AGR----WPHGMAFV---LTVFAAVMTGAYVRD---RRRTIEALRAHLRRERDQQARLAAAEERNRIAREMHD
IIAHSLAIMITLADAAAGKVQTDPDRARGVLRQLAGTGRATLDEARQLVGVLRTDPLAPPPSVR-DLPELVERIRDAGLTASLTVTGDPEA-VPAASGLA
AYRIAQEALTNTVKHARPTRATLTVEISPTATLLTVRDDGRA---AGRRSGP-----AGGHGLVGMRERAAMGHGTLVAGPDPTGGWTVRARLPHA--
>tr|C3JG85|C3JG85_RHOER Integral membrane sensor signal transduction histidine kinase OX=596309 OS=Rhodococcus erythropolis SK121. GN=RHOER0001_4222 PE=4 SV=1
-----------------------------------------------------------TVPLAWRRSRPLSGMVIAGFAVLHVIG-NTLASAVVVPISL
YALAAYGARWSSLTGLVLALLGSIAG-TVRYFGGIPVSQAVA---VMIFAVWAFGDLRRV---RTKQLEGLTELLELERAQEAEIATISERSRIAREMHD
IVAHSLTVVIAQADGGRYSAAKDPQAAIQALETIASTGRQALTDMRSLLSVLREDTPRVIPGAG-DIDSLFHELRSSGLDIAVSVTGEPRE-LSAGAGLT
AYRIVQESLTNVLKHAPGAQASVEMTWAETELVLGITDDGRGG-SAALVESS-----PGGQGLIGMAERAKLHGGKVTAGPKSGGGYSVRAVLPYE--
>tr|F3NMF4|F3NMF4_9ACTO Two component system sensor kinase OX=996637 OS=Streptomyces griseoaurantiacus M045. GN=SGM_4157 PE=4 SV=1
----------------------------------------------------------------------WWLSLAVGFVTAEAVRPWTQASLAAHALVL
LLLALRV-PGRISAEALVLTALVTYAVEGLQASVYSPTGLLAVVVFATVLLGTALRGRRVART--QLVEQATLTAEER----ARRTVLEERSRIARELHD
VVAHHMSVISIQAQVVPHLVENPSAELRENVEGIRGNALEALTELRRVLGVLRSEGSADGQPTLDDVDALVDNVRAAGLEVSTGVTGRRRP-LPPGVELS
AYRIVQEGLSNALRHAPGSRVTVELEHSPEGVRVRVVNSR----PTRTAPPSP----GAGHGLLGMRERTTMLGGTLIATVTPPGGFLVEAFLPGP--
>tr|Q82ES9|Q82ES9_STRAW Putative two-component system sensor kinase OX=227882 OS=NCIMB 12804 / NRRL 8165 / MA-4680). GN= PE=4 SV=1
----------------------------------------------------------------------WWLSLAVTAVSAEAARPWTSQGIMACAFVL
FLLALRV-PVRASIGVLALTTLVTYFLQGIQATAYSPTGLLAVLVFATVLVGAALRGRREART--QLVEQASLTAEER----ARRTVLEERSRIARELHD
VVAHHMSVISIQAQVAPHLVENPSEELRENLAGIRQNALEALTELRRVLGVLRSEGSGTGQPTLARLDALVENTRAAGLTVLTEISGDARP-LPPGVELS
AYRIIQEALSNALRHAPGSTVRVELTHFPRGVQVRVINSR----PQRPVPPSP----GAGHGLLGMRERAAMLGGTLVTSETSCGGYAVAAFLPRS--
>tr|D7C966|D7C966_STRBB Putative two-component system sensor kinase OX=749414 OS=Streptomyces bingchenggensis (strain BCW-1). GN= PE=4 SV=1
----------------------------------------------------------------------WWIAFIADTVGALAVLPWQPPNIIGCLFLL
LFLALRE-PRRTLVAVWLVTGGVGVVLGIP-ARYSDGTNVLMFVLGGVVLVGGALRERGDAQR--RLAEQETISEAER----ARRTLLEERARIARELHD
VVAHHMSVITVQADSAPYRIGGLPPEAEREFGTIAATARESLAEMRRLLGVLRSE-DARGQPGLDRVPQLVEATVRAGIPTTLSIAKDVGT-LPQAVDLS
AYRIVQEALANVVRHAPGAPTNVSISADRTGLTVLVVNGP----PGTPGPPTT----GTGHGLIGMRERVRLVGGTLDTGPLPEGGFRLAARLPLV--
>tr|D6A985|D6A985_9ACTO Two-component system sensor kinase OX=566461 OS=Streptomyces ghanaensis ATCC 14672. GN=SSFG_03367 PE=4 SV=1
----------------------------------------------------------------------WWLSVAAMLVGAMAVRPWTSAGLIAHLFVL
LLLALRV-RTRVSFEALALTGLLTSAVQGLIGRNYQPTGQLAVVLFAVVVLGTALRGRREARA--ELGRQTTLTAEER----ARRTLLEERSRIARELHD
VVAHHMSVISIQAQVAPHLVKDPPEELKENLAGIRQNAVEALTELRRVLDVLRSEEGGSGQPTLDRLGALVENTRAAGLTVTTEVTGERRP-LPPGVELS
AYRIVQEALSNVLRHAPGATAHVTLTYDPRGLRVEVVNTG----PTREAPPSA----GAGHGLLGMRERAVMLGGRLTAGPWSGRGYKVDAHLPVF--
>tr|L1L1Y0|L1L1Y0_9ACTO Histidine kinase OX=698759 OS=Streptomyces ipomoeae 91-03. GN=STRIP9103_05326 PE=4 SV=1
----------------------------------------------------------------------WWASMVVTVVVALGVRPWSPPGMIAHAVIL
FLLALRL-PTRVAVEVLALTALATYVVQGVIAPAYSSTSTLAMALFIGVLLGSTMRGRREART--QLVEQAGLTAEER----ARRTVLEERSRIARELHD
VVAHHMSVISIQAQVAPHLVENPPDELKENLNGIRQNALEALTELRRVLGVLRAEAAAEGQPTLDRLDALVENTRAAGLAVTTEIHGDVRP-LPPGVELS
AYRIVQEALSNALRHAPGSTVRVELTHFPRGLQLRVINSR----PDRPAQPSP----GAGHGLLGMRERAAMLGGTLMATETSHGGFAVVAFLPRN--
>tr|G2NBT8|G2NBT8_9ACTO Integral membrane sensor signal transduction histidine kinase OX=862751 OS=Streptomyces sp. SirexAA-E. GN=SACTE_1868 PE=4 SV=1
----------------------------------------------------------------------WWIVFGADVVGALVLLPWSPTVVISYLFVL
LALGLRE-TRRTLLAVWLTTGTAGLLLYLI-PERDASGVVLLPVLGAVVVITAALRERGEAQR--RLVEQETISETER----AGRTLLEERTRIARELHD
VVAHHMSVITVQADSAPYRISGLPEQAREEFGSIAASARESLTEMRRLLSVLRSD-GTEGQPGLDRIQQLVEATVRSGLPVELSMGTDVDG-LPQAVDLS
AYRIVQEALANVVRHAPGARTRVSVTAAGSHLTVLVVNDR----AQRPGSPAT----GTGHGLVGMRERVRLTGGTLDTGPLPDGGFRVAARLPLS--
>tr|F2R0W1|F2R0W1_STRVP Two-component system sensor kinase OX=953739 OS=JCM 4526 / NBRC 13096 / PD 04745). GN= PE=4 SV=1
----------------------------------------------------------------------WWVIFTADVLGAVVLLPWPPTVVVGYCALM
IALGLRE-SRRALFGVWLATGVAGYALDVV-PAGSTSVHTLLVVLSGVLLLTSAVRARGDAQR--RLVEQETISEAER----SRRTLLEERARIARELHD
VVAHHMSVITVQADSAPYRIPGLPDAAREEFGSIATSARESLAEMRRLLAVLRSD-GTEGQPGLDRLQQLVEATVRAGVPAELRLAADLGD-VPQAVDLS
AYRIVQEALANVVRHAPGASTRVSVRADGGWLTVLVVNGP----SAEAGSQAS----GTGHGLVGMRERVRLTGGSLDTGPLPDGGFRVAARLPLT--
>tr|B5GTE0|B5GTE0_STRC2 Two-component system sensor kinase OX=443255 OS=NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602). GN=SSCG_02649 PE=4 SV=1
----------------------------------------------------------------------FWISLLSTPVVSLSSSPWSLSGFLCHLGVL
VLAALRT-RPGIAGWMWGLTALYTMLAQIFLGGA-PPNSPLMLFFAAVLLITTLVHIRRKAER--DVAAEQSVTAVER----DRRTLLEERTTIARELHD
VVAHHMSVVAIQAEAAPYRVENPPPELEKAFATIRENAVAALTELRRILGVVRAE-----QPVLADLDTLLDNVREAGLTTRKTVTGAVRT-LPQGVELS
AYRIIQEALSNTLRHAPGSTADIEVSYVLGGLGLRIVNTA----PQGLVKPSP----GAGHGLTGMKERVSMLNGGMTHGPTDDGGYEVTAFIPVP--
>tr|F8K3P9|F8K3P9_STREN Putative two-component system sensor kinase OX=1003195 OS=14057 / NRRL 8057). GN= PE=4 SV=1
----------------------------------------------------------------------WWASTGAAALGAWTATAWNGPGLATQAGVV
FLVALLT-RPRVAVEVLVISVLLVTAWDRLLGAGFDHN--LAYEVLVIAIVGAALRSRGVART--QLVVQAELTAEER----GRRTLLEERNRIARELHD
VVAHHMSVISIQAQVAPHLVEAPSAELTENLAGIRQNAVEALAELRRVLGVLRSEALAEGQPTLARLDELVGNVRGAGLAVTTRTTGQPRP-LPPGVELS
AFRIVQEALSNAMRHAPGAGVRVALGYHDTTLTVRVTNTA----PERAASPSP----GVGHGLLGMRERAAMLGGELATGPTPDGGYEVSAILPVQ--
>tr|Q45RA0|Q45RA0_STRFR Probable sensor kinase OX=1906 OS=Streptomyces fradiae (Streptomyces roseoflavus). GN= PE=4 SV=1
----------------------------------------------------------------------WWTIFTADVLGGLALLPWTPMIVVGYQPLM
VLLGLRE-SPRTLIAVWLATGAAGLFFETV-GDRGGGIHLLLFVLSGVTVLTYALRSRGEARQ--RLAEQETISEAER----ARRTLLEERARIARELHD
VVAHHMSVITVQADSAPYRIPGLSPEAREEFDSIAAGARESLAEMRRLLVVLRSE-EARGQPGLDKLQQLVESTVRAGVPAALSLAADVGE-VGQAVGLS
AYRIVQEALANVVRHAPGASTEVSVRADGADLTVRVVNGP----APGPVSPRG----GTGHGLVGMRERVRLTGGTLDVGPLPDGGFRVVAGIPLR--
>tr|D6AZ32|D6AZ32_9ACTO Two component system sensor kinase OX=457425 OS=Streptomyces albus J1074. GN=SSHG_01417 PE=4 SV=1
----------------------------------------------------------------------WWVIFTADIVAAVAMLPWTPMNIVGYQLLM
ICLGLRA-GRRTLLAVWLATGGAGLFFEVL-QEHSDGTQLLTFTLSGALLLSATLRERGDAQR--RLVEQETISEAER----SQRTLLEERNRIARELHD
VVAHHMSLITVQADSARYRIPHLDEEAAREFSSIAESARESLTEMRRILSVLRSE-DAEGQPGLRQLSQLVAATVRAGVPVTMSRTEEIAD-LPASLDLS
LYRIVQEALANVVRHAPEARTTISVSVERDSVTVVIVNGP----GRARRVPTT----GTGHGLVGMRERVRLVGGTLDTGPLPGGGFRVAARLPRR--
>tr|E8WD68|E8WD68_STRFA Integral membrane sensor signal transduction histidine kinase OX=591167 OS=Streptomyces flavogriseus (strain ATCC 33331 / DSM 40990 / IAF-45CD). GN= PE=4 SV=1
----------------------------------------------------------------------WWIVLTADVLGALVLLPWTPPAVVGYLFVL
LALGLRE-SRRTVIGVWLTTGVAGLLLYAL-SARSGGNGVLLFVLGGLVVIGAAVRERSEAQR--RLVEQETISEAER----AQRTLLEERTRIARELHD
VVAHHMSVITVQADSAPYRIGGLSEEARAEFASIAAGARESLTEMRRLLSVLRSD-GTRGQPGLDRVQQLVEATVRAGLPAELSLEADVGG-VPQAVDLT
AYRIVQEALANVVRHAPGARTRVSVTARDGHLTVLVVNDS----PEIPGSATS----GTGHGLVGMRERVRLTGGTLDTGPLPDGGFRVAARLPLP--
>tr|J1S2A5|J1S2A5_9ACTO Signal transduction histidine kinase OX=1160718 OS=Streptomyces auratus AGR0001. GN= PE=4 SV=1
----------------------------------------------------------------------WWVIFAADVVCALALTPWPPPVIVGYLALM
LALSLRE-RRRTLIAVWLTTGAAGILFELA-PAHVQNTWVLLFVLSGVMMMGATLRERGDAQR--KLIEQETISEAER----ARRTLLEERTRIARELHD
VVAHHMSVITVQADSAPYRISGIPKAAEDEFGAIAATARESLAEMRRLLGVLRSE-ETERQPGIGMLPKLVEGTVRAGVPVELALPEESAV-LEPAVDLS
AYRIVQEALANVVRHAPGARTRVSLTADGARLTVLVVNSA----PPAPATPTG----GTGHGLVGMRERVRLVDGSLDTGPLPDGGFRVAAQLPLA--
>tr|H1QTQ7|H1QTQ7_9ACTO Two-component system sensor kinase OX=1120227 OS=Streptomyces coelicoflavus ZG0656. GN= PE=4 SV=1
----------------------------------------------------------------------WWLSLAAMLVGAFAVRPWTAAGLVAHLFVL
LLLALRV-RTRVSLEALALTALLTYLTQGVVGQNFQPTGQLAVILFTVVVLGIALRGRREART--QLAEQTTLTAEER----ARRTLLEERGRIARELHD
VVAHHMSVISIQAQVAPLLVENPPDELKENLAGIRQNALEALTELRRVLGVLRAEEAGDGQPTLDRLDALVDNIRAAGLIVTTGSSGTRRP-LPPGVELS
AYRIVQEALSNVLRHAPGATARVHLTHLPIGLRVEVSNTR----PKRAPAPSQ----GAGHGLLGMRERVAMLDGTLTAHPMPDGGYQVAAFLPAD--
>tr|H0R6S5|H0R6S5_9ACTO Putative two-component histidine kinase OX=1077974 OS=Gordonia effusa NBRC 100432. GN=GOEFS_132_00070 PE=4 SV=1
----------------------------------------------------------------------WGISVVTAVVMTLFVPPWSIQ--VTHIIAL
LVLTAMT-CLRGPIRQIPLVAACTMVLLWF-AAPPDQRGGWIFAI-GFIVVSALLRYLFQSRR--LLAERTEETELAQ----SQQAVLRERARIARDLHD
VVAHRMSTVVVMAQTAQYRLPEELGPLTAEFDGIAVAARESLDEVRQLLGVLRLDNGALANPGMAEIDSLISATRGAGVAVTFTDTTDHTQ-IGESSALV
IYRIVQESLANATRHAPGAQVIVALVGTPDATVLTVVNSV----PITESLDAG----GSGVGLLGMDERAKSVGGQVDTGPTSDGGFAVHAVIPNR--
>tr|C9Z425|C9Z425_STRSW Putative two component system sensor kinase OX=680198 OS=Streptomyces scabies (strain 87.22) (Streptomyces scabiei). GN= PE=4 SV=1
----------------------------------------------------------------------WWLSTVLMAVAAVGARPWTGSGIFAHATVL
FLLALRL-PTRVSAEVLALTALLTYVLQEFVSANHEPSGMLALAMFTGVILGGALRGRREART--QLVAQTSITAEER----ARRTVLEERSRIARELHD
VVAHHMSVISIQAQVAPHLTENPSEELKENLHGIRQNALEALTELRRVLGVLRSEGVTEGQPTLDRLDALVDNTRAAGLAVVTEIHGEVRP-LPPGVELS
AYRIVQEALSNALRHAPGSTVRVELTHFPRGLQVRVINSR----PAREAPPSP----GAGHGLLGMRERAAMLGGTLMATETSHGGFAVVAFLPRD--
>tr|D9X3P7|D9X3P7_STRVR Two-component system sensor kinase OX=591159 OS=Streptomyces viridochromogenes DSM 40736. GN=SSQG_04225 PE=4 SV=1
----------------------------------------------------------------------WWLALGAFVTGAFLLHPWTAAGIVGLLLVL
LLLALRV-PTRAAIAALAVTVLVTFGLESLLGEEYDDTGAIAVPLSAVVVVGTALRGRREARA--QLVEQTTLTAEER----TRRTLLEERSRIARELHD
VVAHHMSVISIQAQVAPHLVENPPDELKENLAGIRQNALEALTELRRVLGVLRSEPIGPGQPTLDRLDALVENTRAAGREVTTEINGERRP-LPPGVELS
AYRIVQEALSNVLRHAPGASAKVRLTYQADGLEVEIVNSR----PTGPAPPST----GAGHGLLGMRERVAMLGGTMTAHPWHWDGFKVTAFLPDT--
>tr|D9WUT1|D9WUT1_9ACTO Putative two component system sensor kinase OX=457427 OS=Streptomyces himastatinicus ATCC 53653. GN=SSOG_06177 PE=4 SV=1
----------------------------------------------------------------------WWIVFLADVTTALVVLPWQPPAIIGYLFLL
LALALRE-PRRTLVAVWLVTGGSGLALGMA-QTKSDGSNVLLFVLSGVVLVGGALRERGDVQR--RLAEQETISEAER----AHRTLLEERARIARELHD
VVAHHMSVITVQADSAPYRIGGLPPEAEQEFGTIAATARESLAEMRRLLGVLRSE-ETRGQPGLRQVPQLVEATVRAGIPTELSLGDEVGA-LPQAVDLS
AYRIVQEALANVVRHAPGAATRVAVAEDGSGLTLLIVNGP----PEGPATPTS----GTGHGLVGMVERVRLVGGSLDTGPLPDGGFRVAARLPLV--
>tr|D9VUV2|D9VUV2_9ACTO Two component system sensor kinase OX=253839 OS=Streptomyces sp. C. GN=SSNG_06323 PE=4 SV=1
----------------------------------------------------------------------WGAVLLADVVGAVLLLPWTPMVVVGYLALM
VCVGLRE-PVRTLVRVGLATGAAGVVLGFF-PAGVTNTVALLFVLSGCVAVTGALRGLGDARQ--RIAEQESISEAER----ARRTLLEERARIARELHD
VVAHHMSVITVQADSAPYRLPGMEEAVREEFAVIAASARESLAEMRRLLTVLRGDPGADGQPGIARIQQLVEATVRAGQPVECSLAAALAP-VPPAVDLS
AYRIVQEALANVVRHAPGAPARVSVSAQDGEVLVLVVNGP----APDAVVERS----GTGHGLVGMRERVRLTGGTLDAGPLPEGGFRVAARLPLD--
>tr|B5HHS7|B5HHS7_STRPR Two component system sensor kinase OX=457429 OS=Streptomyces pristinaespiralis ATCC 25486. GN=SSDG_04753 PE=4 SV=1
----------------------------------------------------------------------WWIVLGADVAGAVVLLPWTPMAVVGYLMLM
ACLGLRE-PRRTLLAVWLATGAAGFALELV-HDLGDGVHLLLFVLSGVVVVTGALRERGDVQR--RLIVQETISEAER----AQRTLLEERARIARELHD
VVAHHMSVITVQADSAPYRIEALPDAAREEFASIASSARESLTEMRRLLAVLRSE-DAQGQPGLDRVQQLVEATVRAGVPAELSLAADLGA-VPQAVDMS
GYRIVQEALANVVRHAPGAPTRVSVTSDGSDLTVLVVNGP----APAPTSPTT----GTGHGLVGMRERVRLTGGSLDTGPLPDGGFRVAARLPLT--
>tr|G2NWJ8|G2NWJ8_STRVO Putative signal transduction histidine kinase OX=653045 OS=Streptomyces violaceusniger Tu 4113. GN=Strvi_7532 PE=4 SV=1
----------------------------------------------------------------------WWIVFLSDIVCALVVLPWLPGPIIGYLFLL
LALALRE-PRRTLVAVWLVTGTAGLSLGMA-PDKSNGSNVVLFVLGGVVLVAGALRERGDAQR--RLAEQETISEAER----AHRTLLEERTRIARELHD
VVAHHMSVITVQADSAPYRIGGLPAEAEREFSTIAATARESLAEMRRLLGVLRSE-ETRGQPGLRQVPQLVEATVRAGIPTTLTIADEVEP-LPQAVGLS
AYRIVQEALANVVRHAPGAATRVAIADDRSALTLLVVNGP----PSAPTKPTS----GTGHGLVGMVERVRLVGGMLDTGPLPDGGFRVAARLPLV--
>tr|D6AUM4|D6AUM4_STRFL Two component system sensor kinase OX=457431 OS=Streptomyces roseosporus NRRL 15998. GN=SSGG_01564 PE=4 SV=1
----------------------------------------------------------------------WWIIFPADIVGALVLLPWPPPTLVAYLFLL
LALGLRE-TRRTVVAVWAATAAAGAVLHLI-SDRATGSALLLPILGAVVVIGAAVRERGEATR--RLAEQETISEAER----AQRTLLEERTRIARELHD
VVAHHMSVITVQADSAPYRISGLSEPAREEFASIAAAARESLGEMRRLLSVLRSD-GTEGQPGLDRLQQLVEATVRAGLPVTLSRAADLGE-VPSAVDLS
AYRIVQEALANVVRHAPGARTQVSVRAAAGHLNVLVVNGP----APKPASPSA----GTGHGLVGMRERVRLTGGTLDTGPLPDGGFRVAARMPLP--
>tr|F8K3C6|F8K3C6_STREN Two-component system sensor kinase OX=1003195 OS=14057 / NRRL 8057). GN= PE=4 SV=1
----------------------------------------------------------------------WWLSLAAMASYAGLSAPWPEPALLAHLIVT
FLTAWRV-RTAVFIAQWALSTAVGAVAWAFFPPGIVPDLLPFAVVSAFGSVLAGLRVRDEARR--TLRKQQRLTEVER----ARRAMLEERTRIARELHD
VVAHHMSVVAVQAEAAPYRVAEPPNELVESFAGIRENALAALTEMRHILGMLRDD-----QPSLDNLDELLDNVRTAGLTVSAAVSGTPRT-LPKRVELS
AFRIVQEALSNALRHSPGSRVEVEVGYRPDAVELRVANSP----ATARVRRQP----GSGHGVLGMRERATTLGGTLRAGRRDDGWYEVVACLPYA--
>tr|I0HJK9|I0HJK9_ACTM4 Putative two-component system sensor kinase OX=512565 OS=/ JCM 3121 / NCIMB 12654 / NBRC 102363 / 431). GN= PE=4 SV=1
----------------------------------------------------------------------WWLGLIAAMPYLILIGPWSVGGIVAILATG
MMVAYQV-PYPVALAQWLIVSAVSVAAELIFDRPQLNNGLVLSGFYAAGAVIATARWLRDVRR--ELRRQVGLTEQER----VQRTALEERARIARELHD
VVAHHMSVIAVQAEAAPYRVTALDPIAAESFTSIRQNALAALTEMRHILGMLRSE-----QPTLADLDQLFDNCRSAGLSLRTDIHGDVWS-LPAQVELI
AYRVLQEALSNAIRHAPGSDVEVEVGYGPAVLNLRVSNSP----APAIPAPRA----G-GHGLTGMRERAAVLGATLRAGPRDDGWYEVSVALPVT--
>tr|D9XJU9|D9XJU9_9ACTO Two-component system sensor kinase OX=467200 OS=Streptomyces griseoflavus Tu4000. GN=SSRG_02999 PE=4 SV=1
----------------------------------------------------------------------WWLSMAATLVGAVLLHPWTASGIVAHLFVL
LLLALRV-PTRVSVEAWGLTFLLTYLLQGVWAVSYQPTGQVLVPLSAVVILGTALRGRREARV--ELGRQTTLTAEER----ARRTLLEERSRIARELHD
VVAHHMSVISIQAQVAPHLVPDPTDELKENLAGIRQNAVEALTELRRVLDVLRSE-----QPTLDRLASLVENTRAAGLTVITEITGERRP-LPPGVELS
AYRIVQEALSNVLRHAPGATAHITLAYAPRGLRVTVVNTG----PTREAPPSA----GAGHGLLGMRERAVMLGGTLTAGPWAGKGYKVDARLPAP--
>tr|K1VIP3|K1VIP3_9ACTO Signal transduction histidine kinase OX=1195457 OS=Streptomyces sp. SM8. GN= PE=4 SV=1
----------------------------------------------------------------------WWLSIGAAVVCAAAMHPWTPAGIVAHLLVL
LLLALRV-PTRAAVATLALTALATWTVQLLLSTREQPVSVLVTSLSAAVALGILVRSRRETHA--ELGRLTALTAEEQ----ARRMLLEERSRIARELHD
VVAHHMSVISIQAQVAPHLVTEPPQELKENLAGIRQNALEALNELRLVLGVLRSEGQDAGQPTLDRLDALVDNTRAAGLTVSVEVTGERRP-LPPGVELS
AYRITQEALSNVLRHAPGATAEIRLEHTRTGLRLTVLNSP----PQQPAPPSP----GAGHGLLGMHERTAMLGGVLTTHRLPDGGYEVSAFLPAD--
>tr|B5GQM7|B5GQM7_STRC2 Two component system sensor kinase OX=443255 OS=NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602). GN=SCLAV_1618, SSCG_01651 PE=4 SV=1
----------------------------------------------------------------------WWIVGAADVLGAVVVLPWSMPGIVGYLVLM
VFLGLRE-TRRTLLAVWLATAAVGMAFELV-QTRSEGTHVLLTVLSGVVLFTGALRERGEAQR--RLAAQETISEQER----TRRTLLEERARIARELHD
VVAHHMSVITVQADSAPYRIEGLPPQAREEFTAIASGARESLTEMRRLLAVLRSE-SAGGQPGLSRLQQLVEATVRAGVPARLALGVAPEG-VPSAVDLS
AYRIVQEALANVVRHAPGAETRVSVTSDGTDLVVLVVNGA----AGAPVSPGA----GTGHGLVGMRERVRLTGGTLDTGPLPDGGFRVAARLPLT--
>tr|F2RJA0|F2RJA0_STRVP Two-component system sensor kinase OX=953739 OS=JCM 4526 / NBRC 13096 / PD 04745). GN= PE=4 SV=1
----------------------------------------------------------------------RVLCFTGAVSFAELVNTRPAT-IAMSAVVA
LYTVASR-TDRPTTWRVGLVTTVLLTAAAMFPTPWYAQNIGIIAWTGMAAAGDAVRSRRDAIR--ERAERAERTREEE----AGRRVAEERLRIARDLHD
VVAHHIALVNVQAGVAAHVMDKRPDQAKEALAHVREASRSALDELRATVGLLRQYGDPEAAPGLAVLDGLLDSFRKAGLPVALARADGDPP-LPATVDLA
AYRIVQEALTNVRKHAPDAEAEVSVVRVGRTVEITVLDNGA--APAAPAEPPP----HSGHGLLGMRERVGALGGTLTAAPRYGGGFRVQAILPVT--
>tr|D9X2A7|D9X2A7_STRVR Two-component sensor kinase OX=591159 OS=Streptomyces viridochromogenes DSM 40736. GN=SSQG_04094 PE=4 SV=1
----------------------------------------------------------------------AAVTVAGSCTVTAIALYLVTPLLLAPIMAA
LYWLAAL-TDRRSIRVYGLTTLVAVTLAAVFDSMNHVSTIGPIFWLMLPAAGKTTQLRRQSVH--ARAEHAERTREEE----ARLRVTEERMRIARELHD
VVAHHMALANAQAGTAAHLALTHPEQTQKILTDLTGTTSSALRELKATLGLLRQNGDTSGSPGLARLPELVSACASAGLEVTVTTEGEPRP-LSPGVDLT
AFRIVQEALTNVSKHAAEA-ARVTLEYTGARLLITVTNDG----PSKP-EAPA----GRGFGVMGMRERAHSIGGELRAGPRPQGGFEVATALPLQ--
>tr|F8K0Z1|F8K0Z1_STREN Two-component system sensor kinase OX=1003195 OS=14057 / NRRL 8057). GN= PE=4 SV=1
----------------------------------------------------------------------TVLAATCLITAGYTVAPLATTPLVITVVVA
VFTVASR-TDRSTTWRLGAATCLGMTAVVMYPGPWYAQHFGVLAWTGLAAVGDAVRSRRAAME--ERAVRAERTREEE----ARRRVAEERMRIARELHD
VVAHHIALVNVEAGVAAHVMESRPDQARAALAHVRQASRSALDELRATVGLLRQAGDPEAAPRLAALDDLLAGFARAGLHADLVRGEAAGP-LPAAVELT
AYRVVQESLTNVHKHAPGARAQVRLVRTPGRLEITVEDDGR--GPAG--DPVA----GGGHGLIGMRERAAALGGVCRAGPRPEGGFRVFVTLPSA--
>tr|A7NID8|A7NID8_ROSCS Integral membrane sensor signal transduction histidine kinase OX=383372 OS=Roseiflexus castenholzii (strain DSM 13941 / HLO8). GN= PE=4 SV=1
------------------------VMIVGALIAAVTAQP-WKRGVVVGALSILLALN--LSD-IRPRSTPQTAIYLMLASALYFVAFSLSSGAASTVISM
LLFLLQAL-------------IGV-CGMIA---GLEVALQSAAFSFGVVFVTMFVRYEQQ-ARAEELLAQLQASHDELAARERELKMIEERVRLARDIHD
GLGHYLTILNVQLQAASRLLQRDPERAAAVIVTCREVAQTALDEVRRSVAAMQPSPLD-GHSLDVAIERLIDDFRLSTIDVRFVQAGDLPA-LPQTLAMT
LYRAVQEGLTNARKHGNASQIDVTLTFLPETARLTIRDNGQP---NNGA-------HEGGFGLTGLRERIERLGGVLRAGPLPEGGFLLDIIAPVA--
>tr|A5UYS5|A5UYS5_ROSS1 Integral membrane sensor signal transduction histidine kinase OX=357808 OS=Roseiflexus sp. (strain RS-1). GN= PE=4 SV=1
------------------------VMIVGALIAAVTAQL-WRRGIVVGALSLLLALN--FTN-TRSRPESRVALYLTVASPLYLVAFGMSSGPASSVIVM
LLFLLQAL-------------IGV-SAIIA---SLEAALQIAALGFGIVFVMMFIRYEQQ-ARAEELLAQLQASHAELAARERELKMIEERVRLARDIHD
GLGHYLTILNVQLQAAARLLQRDPQRAAAVIATCREVAQTALEEVRRSVAAMQPSPLD-GQSLDAAIEHLINEFRTSTLDIHFEQSGDLPV-LPQTLAMT
LYRAVQEGLTNARKHSNATRIVVNLTCLPETVHLAIRDNGQP---VNGV-------GQSGFGLTGLRERIERLGGSLHAGPHPDGGFLLDIVAPAD--
>tr|B8G5G0|B8G5G0_CHLAD Histidine kinase OX=326427 OS=Chloroflexus aggregans (strain MD-66 / DSM 9485). GN= PE=4 SV=1
------------------------AMISTALVEFILFHPPERFYVVIVLLSVLLSLNAVWER-LQQRWGNADRVFFSTSSIIFLAANYIGLDAGWTFLPF
LLFVIQALGVWRGLGVSLLLYLGW-CGVLWLRGPLIQIVVQAPIALGLIFVLIFSRLVEQTARAERLAAELQSVNVALAAREREVELAEERVRLAREIHD
GLGHHLTALNVQLQAAARLLNRDPERAAQALAICREEAQAALNEVRQSVAVMRNAPVN-GRPLPEVIAKLVADFKRVSLHVQFVVEGEIGE-LPLTVAMA
LYRAVQEGLTNAQKHGQGTTVTVRLIGEVGQVRLEVVNDGPP---APPV-------AETGFGLAGLRERAARLGGTLHAEPLPAGGFRLAMVVPHV--
>tr|B9LK89|B9LK89_CHLSY Integral membrane sensor signal transduction histidine kinase OX=480224 OS=Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl). GN= PE=4 SV=1
------------------------AVITVALVEYILFHPAERFYPVIVLLSLLLALNAAWDS-LQLRWGDANRLFFGLSSLIFLVVNYLGLDEGWTFLPF
ILFVIQALGIWPGLALSLLLYAGW-NGVLWLRGSSTQILTQAPIALGLIFTLIFSRLSEQMARTERLAAELRAANEALASRERELALAEERVRLAHEIHD
GLGHHLTALHVQLQVAARLLEHDPVRAAQALHLCREAAQAALTEVRQSVAIMRSNPLA-EQPLPVVIERLVHDFSRVAFQIRFEQAGEIGE-ISPAMVMT
LFRAAQEGLTNVQKHAQATCVTVRLIADTESVRLDVINDGPP---APAI-------GETGFGLAGLRERVSRLGGEIQAAPQPEGGFRLAIVLPRR--
>tr|F2RDL6|F2RDL6_STRVP Putative two-component system sensor kinase OX=953739 OS=JCM 4526 / NBRC 13096 / PD 04745). GN= PE=4 SV=1
----------------------------------------------------------------------RRWATTLSAQALLTYLPIAVFHSQWGAMAG
FLAGSLLLPSRWAWPAYGVVGLTMLGPPT-LD-GLTFQETFYLCLSTLLTGLVVFGL----SRMTELVQALHATRGQLAGL----AVTKERLRFARDLHD
LLGYTLSAITLKSELIHRLIPTHPERAMHEVSEVLVISRQSLADVRSVSSGLRRMSLEQE--LGAARSLLQA----ADVDVRTDIRL--AG-LDGQVDSM
LAAVLREAVTNLLRHSDVRTCTLEAVQEHGWVRLTVINDGVDPAYRESP--------DSGSGLGNLRARLLNASGRLTVARGPAGTFSLTAEAPAR--
>tr|D6K3L5|D6K3L5_9ACTO Two-component system sensor kinase OX=645465 OS=Streptomyces sp. e14. GN=SSTG_03906 PE=4 SV=1
----------------------------------------------------------------------RQKTVTLGAQALLTYLPILLFHAQWGGMAG
FLAGSLLLPPRIAWASYAAVGLSMLLPPV-LD-GRSLVDSFYLCQSTLLTGIVVFGL----TRLADLVHVLHDTRGRLARM----AVTKERLRFARDLHD
LLGYSLSAITLKSELIHRLLPGNSQRALTEIREVLAISRQSLADVRTVASGMRDMSLVEE--VNAAEGLLVA----ADVDTRVTLQQ--GT-MSPQVSTV
LAAVLREAVTNLLRHSKADGCVIEAVQHGGRIRLVVENNGVQPDYCLSV--------HSGSGLGNLASRMREIAGELHTGFGPDDTFRLVAEAPAF--
>tr|E2Q9C9|E2Q9C9_STRC2 Putative two-component sensory kinase OX=443255 OS=NBRC 13307 / NCIMB 12785 / NRRL 3585 / VKM Ac-602). GN=SCLAV_0473 PE=4 SV=1
----------------------------------------------------------------------RWGRWTLALQALLTYLPLFAFGFVWGGMAG
FLGASLVLPSRLAWPLFGAVGVIACVTGP-ML-DRDIVTSVYIGVSTILTGLIVYGL----SRLANLVIEVQEAQQALARL----AVSQERLRFARDLHD
LLGYSLSAITLKSELARRLVHCEADRALEELENILEISRQALSDVRTVARGYRDMSLATE--AVSARAVLEA----GGIQATVEIRG--KL-PEGETSTI
MATVLREAVTNLLRHSKAEHCRIESWTTAGRLVLTIANDGVEREQLPSG--------RDGSGLHNLQFRLAAIGGRLSSHVDDKGWFVLTAEAPIS--
>tr|G2NX80|G2NX80_STRVO Putative signal transduction histidine kinase OX=653045 OS=Streptomyces violaceusniger Tu 4113. GN=Strvi_8160 PE=4 SV=1
----------------------------------------------------------------------GARRWTLTLQAVLTFAPFAVFKHAWLGMPG
FLAGSLVLAPALAWPMFAAILLCTDALLF-QV-GFGWGQVAYTSVSTALTGLVVFGL----SRLSGLVAEVSRSRAELARL----AVAQERLRFSRDVHD
LLGYSLSTITLKCELVHRLVPRQNSRAQQELSEILQTCRQALADVRAVASGYRKMSLSAE--SATARSMLAA----AGISATSAIDC--GP-LPELVDTV
LASVLREGLTNVLRHSKADHCAIEARRSGHQVWLTLVNDGVGRPSTDST--------DGGSGIGNLRVRVENLGGRLRAGVRPDGCFELRAEAPSR--
>tr|K1W3J7|K1W3J7_9ACTO Histidine kinase OX=1195457 OS=Streptomyces sp. SM8. GN= PE=4 SV=1
----------------------------------------------------------------------LRRCATLGCQAVLTFAPLVFFQSQWGSMAG
FLAGSLLLPPRWAWPAYGVVGLTMALPPL-LE-GLPLRDAFYLAQSTLLTGLVVYGL----SRLAELVQVLHHTRVELTRM----AVTQERLRFARDLHD
LLGYSLSVITLKSELIHRLVPSHPERAMEEVGEVLAVSRKSLADVRSVAAGLRGMSLEQE--LSSAESLLRS----ADVTVHADIRL--GA-IDPEVDTV
LAAVAREAITNLLRHSRAGVCAITAVREGGNVRLRISNDGVDPGYRMSP--------HSGSGLGNLETRLRAVQGRLTVSRAEAETFALTAEAPAR--
>tr|C9ZCC8|C9ZCC8_STRSW Putative two-component sensor kinase OX=680198 OS=Streptomyces scabies (strain 87.22) (Streptomyces scabiei). GN= PE=4 SV=1
----------------------------------------------------------------------RWHRWTLTAQALMTYLPLFVLGFGWGGMAG
FLGASLVLRPQVAWPLFGLVAVAAAATGP-LL-GKDLVDSAYITVATVLTGLIVYGL----NRLAQLVVEVHAAQTELARL----AVTQERLRFARDLHD
LLGFSLSAVTLKSELACRLVPAAPDRALEELRSILEISRQALSDVRTVARGYRDMSLTSE--AVSAQAVLAA----AGIQAEVRCSA--EP-PEGEVNTI
MATVLREAITNLLRHSKAEHCRIDCRRTSGKLVLTIANDGVQKTATSSG--------ADGSGLGNLQFRLASIGGRLTSGLDEEGWFVLRATAPLH--
>tr|G0PXP1|G0PXP1_STRGR Integral membrane sensor signal transduction histidine kinase OX=649189 OS=Streptomyces griseus XylebKG-1. GN=SACT1_3095 PE=4 SV=1
----------------------------------------------------------------------RRRWWLLLVQAVLTYLPLLLFNYRWLSLLG
FLAGALTLPPNASVPIALAVGASGPVLST-TD-LITTDRSLSILLSTAITASTVFAV----AHLALLAARLGANREHTAHL----AEQRERARMQQDLHD
LVGSSLTAIVLQGEVALRSPSPAPERARGALTEIIALARRLHDDVRSISRPDGDLSLSDE--LAHAQRVLAA----SGVEVRTVLPPW-AE-PDPAVVGC
LRFVLREAVGNVLQHSRATSCEIALRADGGQMRLTVRNDGAAEGR--APAD-----GAPGRGLAGLAGRVIALGGTFTTT-SEDGTFVLTAAVPAA--
>tr|C7R5B4|C7R5B4_JONDD Histidine kinase dimerisation and phosphoacceptor region OX=471856 OS=(Listeria denitrificans). GN= PE=4 SV=1
-----------------------------------------------VGLVIGFAVVYMWGFRFVFGPPERSVWWVFVVLTALTGLSVLVGPVALATLPV
AAACYLLRRPVAVVVAMFY--VLGVVTVLRGLGVWD-ELSFIPWVAGVFA--GFVLSS---VF----IGDVRT-----MQVEQELAVTRERERLARDVHD
SLGHTLTVVSIKAELASRLVSSQPERAARELVEVRDHVRDALSQVRDVVTGLT------HHSIADHVSA--LRYSMDGAGLDVEVTGSMQG-VPQRVVES
VGWIVREAGTNVLRHARASRCTIAVTS----RDLTITDNGVGIPAVAAG-SDTMSMRGPGHGITSMTQRAADAGLTLTITVPAGGGTTLTV-------
>tr|C3JE80|C3JE80_RHOER Two-component system sensor kinase OX=596309 OS=Rhodococcus erythropolis SK121. GN=RHOER0001_2511 PE=4 SV=1
-----------------------------------------------ILATIAFSALYLYTFRRMTRPTIREAALALSALTALAVMIVSVGPTGLTAAPL
AVTAVTLLPTVAGGILALV--FAASVEIVSLSSGWG-NYSGLSLCAAAFATWGMSLIS---RN----FAILHE-----REEQEQRAIMEERTRMARDLHD
ILGHSLTVITIKAELANRLLDVDIERARNELDDLERLSRDALADVRSAVEGFR------GISLPVEIAR--AREALRAAGIEDEVPSSTDM-VPTRLREL
FAWTIREGVTNVVRHSGATHCRITVDE----NSASVVDDGRG-----AE-ST-----SSGNGLIGLRERAGASGARVIITHPQPQGFALVV-------
>tr|I6X4U7|I6X4U7_PROPF Histidine kinase OX=767029 OS=Propionibacterium propionicum (strain F0230a). GN= PE=4 SV=1
-----------------------------------------------LLALVLFVPVYLAGFDLLDAAGRR---WQLLFVLAVMVLCWAIGLDAISLLPV
TFASYGLWPPVRLPAVVVL--VGSGFLILTLMNEPD-AGNSVNMITALVAVLGLTVKT---IE----SGIVIS-----EQNRRRAAL-EQRERMARDVHD
LLGHSLTVANLQLQLAERLFDSDPERARAELARTRIFLGEAQEELRRSVTDHR------GRTIEEELDG--VRGVLLSGGLEVAVTGDSDE-TTGPIGLV
LGWVLREAATNVLRHAHATRVEISFAP----GRFSVADDGDGYA--G----------GEGNGLTGMRERVAAAGGELRCGASPLGGFEVVV-------
>tr|K0YJM8|K0YJM8_9ACTN Uncharacterized protein OX=742818 OS=Slackia piriformis YIT 12062. GN= PE=4 SV=1
---------------------------------------------------------------------RRVAPWLAIVLACFFFSSGYMSGFALSAIPM
VAVCSYLLDRRHAV-VAGLLTATVM--LLAPTPLPSETLATVMVVAAALAGFALRTYRAYMAETHRRLEEAERSREELAARR----VAEERVRIARDVHD
ITAHSLSAVAIQAAAAERLVDSDPAAAKEAIADIRLVSKGALDEIRSMIGVLR-GDEKPESEGTERLADVVEYLRRASLEVTCATKGYRREDVPAIVDMA
LFSLVREAATNTVRHAQANSVDILLRSTATQASLVFSDDGV--GLADDV----------GHGLEGMKERIEALGGVFSI-DGSHGGCVLKAEIPLE--
>tr|C7MLQ8|C7MLQ8_CRYCD Signal transduction histidine kinase OX=469378 OS=Cryptobacterium curtum (strain ATCC 700683 / DSM 15641 / 12-3). GN= PE=4 SV=1
---------------------------------------------------------------------RRRFPWLVFTFTLFVMSQGLAPSYSFSIIPA
IALFAVERPRTEII-IALAISIVVL--FWMPPPGENDSIRLVVLALSAGIGVAYHMHRSFLREVEQRVAEVERTREKEAARR----VEEERVRIAREIHD
ITAHSLSAVSIQAAAAERLIDRDPAAARGAIAEVRKTAKSALEEIRSMIGVLRNESQEVETNGTDRLPDLCAYACNAGLEATLETDGYDAHKVPAYVDVT
VFGIAREALTNVVRHAQAKKVRITLSQEADQVHLRIEDDGCGIPEGPSASMKASAASGRGHGLQGMEERVYVLHGSFSAANRPQGGFAVDVRIPLQ--
>tr|C8WN47|C8WN47_EGGLE Histidine kinase OX=479437 OS=11813 / VPI 0255) (Eubacterium lentum). GN= PE=4 SV=1
---------------------------------------------------------------------RRRFPWFLFCLVSFLGLQNAFNGFSLTIVPV
VALYASERGRAETV-AAVLLAVAGL--LFADAHAATANMVLFTAVAAGLAGYAYRTHRAYVKATEDRAAEAERTREEEAARR----VEEERVRIAREVHD
ITAHSLSAVSIQAAAAERMIDRDPAAAKEAISAVRTTAKGALADIRSMIGVLRCGDDAAETSGTERLDDLRAYLGNAGIETTLDAAAYCRADVPAHVDMA
LFGIAREAATNIVRHAGAHKALIRLAVEDGRARLVVEDDGVGCGLSASAAASGALVDGEGHGIAGMAERVHLLGGTFSAGDRAGGGFRVVACLPMK--
>tr|D9WWD8|D9WWD8_9ACTO Putative two-component system sensor kinase OX=457427 OS=Streptomyces himastatinicus ATCC 53653. GN=SSOG_06308 PE=4 SV=1
----------------------WLFMLTPDARHLFDRGTP---LPWLLGLTAF-VGAYVAATGLDPRR-R--RAPLLALAGLAAVAFALGIGYAWLLFPL
LSLTGIVLRGHRPVILVFACSAGVIASL---RGGPDSFTIGYGTVLSGLVTAAVLSLFE-------TVAQLRATRQELART----AVEKERLRFSRDLHD
LLGHTMSVVVVKAEAVRRLAPRDLEAALGQAADIEAVGRQALTEIREAVTGYREGSLDTE--LDRARSALDA----SGIEADV------GPPLSPQAEAL
LGWVVREGVTNVVRHSGADHCEIDVRGGIGRVRLVITDNGHGVG--------S-----GGTGLKGLAERLAVAGGSLESGPDGRRGFRLVAELP----
>tr|D6JZ82|D6JZ82_9ACTO Two-component sensor kinase OX=645465 OS=Streptomyces sp. e14. GN=SSTG_01075 PE=4 SV=1
----------------------WLLMGLGSLSNVLKGETP---NPWIVGLLAF-NSLYVYVRAFDKER-R--RSTRVVLVVMGVLTTALALGYGWLLFPL
LGLTGATVRGPSRVGLLLAAFAGAVSGY---REGWNGINIAYATFLSTMVTAAILSLSE-------AVRELRAAREELARR----AVEEERLRFSRDLHD
LLGHTLSVIVVKSEAARRLAPRSMDAALSQITDIESVGRQALTEIREAVTGYREGSLSTE--LDRARSALTA----AGIEPVV------GPPLTPQTEAL
LGWVVREAVTNAVRHSGAARCEITVAGAAERVRLTVSDDGRGAS--------A-----GGTGLKGLTERLATAGGSLTAGPSARGGFTVTAELP----
>tr|H2K069|H2K069_STRHJ Two-component sensor kinase OX=1133850 OS=Streptomyces hygroscopicus subsp. jinggangensis (strain 5008). GN= PE=4 SV=1
----------------------WLLLGMGSLSNVLQGETP---NPWILGLLAF-NSLYVYVRAFDRAR-R--ASTRVALGLLGLVTTGLTLGYGWLMFPL
LGLTGATLRGPWRVGLLLTLYAGAATWL---RDGWDDASIAYATFLSSMVTAAILSLSE-------AVRELRAAREELARR----AVAEERLRFSRDLHD
LLGHTLSVVVVKSEAARRLAPRDLDAALAQVSDIESVGRQALTEIREAVTGYREGSLATE--LTRARSALSA----ASVQPVV------GAPLAPQTEAL
LGWVVREAVTNVVRHSRADRCEITVEGAADRVRLTVTDNGTGTG--------T-----GGTGLTGLTERLAAAGGSLTAGPAPRGGFTVTADLP----
>tr|J1RSA1|J1RSA1_9ACTO Two-component system sensor kinase OX=1160718 OS=Streptomyces auratus AGR0001. GN= PE=4 SV=1
----------------------WLLYLAGPVGRMLEPGISLAE-RIWLGLTLF-VLAYCLLRHLWRKT--GLLPMYG-LAVMLALSVTLSWVLDWLVFIF
TSVSAVVLPWQQAIPLITAVVLAIG---ANIHGYYFAYG--LPALGSGFMMVGVQYLIR-------TTTELRAARQEVARL----AANDERLRLARDLHD
LLGHSLSLITLKSELAGRMLPDRPEDAARQVADIEQVSRQALVDVREAVTGYRRPRLAVE--LAGARAALRT----AGITVTAALEG-EYRGLAADEEGV
LAWALREAVTNVLRHSGAHRCELLLSEEWEFLCLTVLDDGAGPP--------R----ADGNGLSGLRERLGPVGGRLETGPARGRGFALRAYVP----
>tr|G2NT00|G2NT00_STRVO Putative signal transduction histidine kinase OX=653045 OS=Streptomyces violaceusniger Tu 4113. GN=Strvi_1449 PE=4 SV=1
----------------------WMAYMGAPVSDLADGHHTVPA-TVCLGLLAF-VAIYLVLRHTGRV---LSRAVFGALGTSCVLAAVLTLTMGWLVCVY
VSVYGAVLPLRLAIPLNTAFMVAVG---VLVRGSHLLSALVIPSLLGGFAMSGVRQMVR-------TTRALRAARATVAQL----AANEERLRLARDLHD
LLGHSLSLITLKSELAGRMLPDKPEQAARQVADIERVSRQALVDVREAVSGFRRPTLEAE--VAGARTALAA----AGIAADLSRAT-QHSDLPPDQEGA
LAWALREAVTNAVRHSGARRCAVTLDETDDELCLTVTDDGRGAT--------G----PHGNGLTGLAERLQLADGRLETGPGERGGFTLRALVP----
>tr|E4NGI6|E4NGI6_KITSK Putative two-component system sensor kinase OX=452652 OS=A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae). GN= PE=4 SV=1
----------------------WALYLAYPVQDLTGGQHTPAA-STAVALAAF-LACYLSLIRNHP----GLREARRYLALMAGIAVTTSYTLGWLTFTY
TSVASVILPGRYGVLATTGLFAAVG---LTADAETVSIG--LPCLMAGLAMLAMQRLVT-------TMRELREARAAVAHL----AASEERLRLARDLHD
LLGHSLSLIAIKSELTGRLMDAGKADAARQVADIEQVARQSLADVRGAVSGFRRPTLPVE--LAAARTALAA----SQIALDARLAE-ERPGLAAEESGV
LAWALREAVTNVVRHTGATRCAVHLDETWEYAVLEVVDNGAGPG--------K----SAGNGLAGLGERLAQAGGRLETGPARGRGFRLRALVP----
>tr|D7CB53|D7CB53_STRBB Two-component system sensor kinase OX=749414 OS=Streptomyces bingchenggensis (strain BCW-1). GN= PE=4 SV=1
----------------------WLFMLTGDVKDLIQGKTP---LPWLLGVTAF-CALYATTAGLDKRR-R--RRCLASLAGLAALTYALSIGYAWLLFPL
LSLTGIVVRRRQPLLLAYSGSAGIISGW---RGGSDALTVGYGTMMSGLVTAAILSLFD-------TVAELRATRQELART----AVEKERLRFSRDLHD
LLGHTMSVVVVKAEAVRRLAPRDLDAALGQAADIEAVGRQALTEIREAVTGYREGSLATE--LDRARSLLDA----SGIDAVV------GPPLPPQTEAL
LGWVVREGVTNVVRHSGAGRCEIEVRQEADQVRLEIVDDGNGVG--------S-----AGTGLKGLAERLAAAGGSLETGPAGRRGFRLAAALP----
>tr|G8WUQ0|G8WUQ0_STREN Two-component system sensor kinase OX=1003195 OS=14057 / NRRL 8057). GN= PE=4 SV=1
----------------------YMLYMASAVGNLVAVRHSTPG-LVFLGLAAF-VGPYLYLTRKGRR---GFQLWQGALVWLYALATGLTFAYGWLVLIY
VAISGAVLPVRKAVPGVALSLLGVG---LLVHGNEMLAGEFFPALLGGAAMFGVVQMRR-------TMRELREARATVARL----AATEERLRLARDLHD
LLGHSLSLITLKSELAGRMLPDRPDDAAKQVADIEQVSRQALVDVREAVSGFRRPTLGVE--LAGARTALRT----AGVEASISAHQ-RPPGLGPEEEGA
LAWALREAVTNIVRHSGAGHCELLLDEVWEYLRLEISDDGRGPG--------R----AAGNGLGGLEERLALSGGRLRTGPSRTAGFCLQAYVP----
>tr|G2P6T4|G2P6T4_STRVO Putative signal transduction histidine kinase OX=653045 OS=Streptomyces violaceusniger Tu 4113. GN=Strvi_7394 PE=4 SV=1
----------------------WLFMLSGDVQALFKGKTP---LPWLAGAAAF-VALYVTATSLDERR-R--RTPILALAGLAVVTYALGVGYAWLLFPL
LSLSGIVLRGGRPVILVLSGSAGIIAGI---RGGADSLTVSYGTILSGLVTAAILSLFE-------TVAQLRATRQELART----AVEKERLRFSRDLHD
LLGHTMSVVVVKAEAVRRLAPKDLEAALGQAADIEAVGRQALTEIREAVSGYREGSLATE--LDRAHSALDA----AGIEAAV------GPPLAPQTEAL
LGWVVREGVTNVVRHSGAARCEIEVRGGMDRVRLEITDDGGGVG--------S-----GGTGLKGLAERLSAAGGSLESGPGGRRGFRLVAELP----
>tr|F8K355|F8K355_STREN Putative two-component sensor kinase OX=1003195 OS=14057 / NRRL 8057). GN= PE=4 SV=1
----------------------WVLMAFAPAADILHQRAT---PPVVAGLAVH-VALYVATSAFRPGT-K--PLPRRLLAALAVVTYALAIAFGFDMFIL
LSLCGALLRGLRQVMMALGASAGLVAAL---RGADDAVSTGYSTMLSGLVTAAILTLHD-------AVSQLRATRQELART----AVSQERLRFSRDLHD
LLGHTMSVVVVKAEAVRRLAPRDLDAALAQAADIESVGRQALTEIREAVSGYRECSLATE--LDRARSALDA----SGITPRV------GPPVPPQTEAL
LGWVVREGVTNVVRHSGAGSCVITVDTGGDRARLEITDDGDGSG--------A-----SGTGLTGLTERLAMAGGSLRAGPDARRGFRLVAELP----
>tr|A0LRA8|A0LRA8_ACIC1 Putative signal transduction histidine kinase OX=351607 OS=Acidothermus cellulolyticus (strain ATCC 43068 / 11B). GN= PE=4 SV=1
----------------------WLFYLLGPLIAAWRSSSP---VAVVFLLLAF-SVVYLFGRVWPAAR-R--RRDVVLVSGTLVILSAASIALIALAWVF
VAVWVVLLRWQIPLVLALAAAALAVPQH---VPGWHLRGPQWSLAASAFASFAVLAVVR-------ANQSLAAARAEVAQL----AAERERLRIARDLHD
LLGHSLTTITVKAALAARLADRDLTRARNEIADVEALARRTLADVRAAVAGYRDVRLATE--IATAREVLAA----AGIEADL------VDDVPAELAGL
FGWVVREGVTNVVRHSQAKRVRITV----DQRVIEVVDDGVGVL--------S-----GGHGLLGLAERVAAAGGRLITGPAGAPGFRLRVEVP----
>tr|L1L863|L1L863_9ACTO Histidine kinase OX=698759 OS=Streptomyces ipomoeae 91-03. GN=STRIP9103_06506 PE=4 SV=1
----------------------WLAYLSAPVGDLLHGGHSDGV-VVLIGLVAF-VAWYFALRTGRGE---TEGVVLGSLAVLATQSTVLALTLGWLVFVY
VAISGAALPFRLTIPAVSVLLTGVA---LAIPGGAFLAGLLFPALLGGFSMTGVRELIR-------TTIELREARATVAQL----AANEERLRLARDLHD
LLGHSLSLITLKSELAGRMLPAHPDKAAQQVADIEQVSRQALVDVRAAVSGYRRPRLSAE--LAGAKVALTA----AGVTADLPAET-DLADVPETSESA
LAWALREAVTNVVRHSGARRCTVGLVHRQTVIELTVEDDGTGGK--------D----NPGNGLTGLAERLQKAGGTLDAGPSRH-GFRLVARAP----
>tr|B5HXU1|B5HXU1_9ACTO Two-component system sensor kinase OX=463191 OS=Streptomyces sviceus ATCC 29083. GN=SSEG_09428 PE=4 SV=1
----------------------WLVYLSAPVSDLLHGGHGAVA-VVLLGLAGF-VAWYLALRTGRRN---AQEFVLVSLAVLSAESTLLVLTLGWLVFVY
VSISGAALPLRLTIPAASALMAILA---LLVADGTYIGALLIPALLGGFAMTGVRELVR-------TTIELREARARVAQL----AANEERLRLARDLHD
LLGHSLSLITLKSELAGRMLPAHPDKAAQQVADIEQVSRQALVDVREAVSGFRRPRLAAE--LAGAQVALTA----AGVTATLPPEP-DLAGVPEESESA
LAWALREAVTNVVRHSGARGCTVELLHRQTRLELTVEDDGSGGA--------G----NPGNGLTGLTERLEKAGGTLEATGTRR-GFRLVARVP----
>tr|D9XD11|D9XD11_STRVR Two-component system sensor kinase OX=591159 OS=Streptomyces viridochromogenes DSM 40736. GN=SSQG_05165 PE=4 SV=1
----------------------WLVYLSAPVTDLLHGGHSTGV-SILLGLAAF-VAWYMALRTGRGE---RDGLVLGSLGVLAAQSTLLALTLGWLVFVY
VSISGAALPLRMTIPAACALLTAVA---LAVPGGHFLGGLLIPALLGGFAMTGVRELVR-------TTIALREARATVAQL----AANEERLRLARDLHD
LLGHSLSLITLKSELAGRMLPDHPGKAAQQVADIEQVSRQALVDVREAVTGYRRPRMSGE--LAGARVALTA----AGVTAELPADT-DLADVPEESESA
LAWALREAVTNVVRHSGARRCTVELLRRQTVLELTVEDNGSGGR--------G-----HGNGLTGLTERLTKAGGTLEAAPYKH-GFRLVARVP----
>tr|D9VXU7|D9VXU7_9ACTO Two-component system sensor kinase OX=253839 OS=Streptomyces sp. C. GN=SSNG_04658 PE=4 SV=1
----------------------WLFYLSAPVTDLVSGGHSTGA-RLLLGLLAF-TCWYLVLRTVKMM---PVPRVLVSLAVLATQATVLSLTLGWLVFVY
VSISGAALPGEVTVPGATALLTAVA---LAVPGGTYLAGLVVPALMGGFAMVGVRAMIR-------TTIELRQARATVAEL----AANEERLRMARDLHD
LLGHSLSLITLKSELAGRMLPEHPERAAQQVADIERVSRQALVDVREAVSGYRRPTLPGE--LAGARTALAA----AGVAADLPAGC-DDAELPEETESA
LAWSLREAVTNVVRHSGARRCTVTLTTRQTVVELSVTDDGTGGP--------A----VPGNGLTGLTERLEAVGGTLSAGPVGRTGFRLLARVP----
>tr|Q82IK0|Q82IK0_STRAW Putative two-component system sensor kinase OX=227882 OS=NCIMB 12804 / NRRL 8165 / MA-4680). GN= PE=4 SV=1
----------------------WLVFLSSPVHDLASGHHTPAA-TAALGLAAF-VGIYLTLRNMGRA---LNGPAVAALVVLGVLAVVLCLSLGWLGFVY
VSVCGTTFPLRVTIPLTAVAMLLVG---L--HGGEDARNLVLLVVLIGFAMTGVRQLVR-------TTVELRKARATVAQL----AANEERLRLARDLHD
LLGHSLSLITLKSELAGRMLPDHPEKAAQQVADIEQVSRQALVDVREAVTGYRRPRLAGE--LAGMQVALTA----AGVTADLPAEP-DLDGVPEESESA
LAWALREAVTNVVRHSGARRCVVELVHRQTVLELSVEDDGSGGS--------G----SPGNGLTGLTERLEKAGGSLDAGRVRR-GFRLVARVP----
>tr|G2NFJ7|G2NFJ7_9ACTO Integral membrane sensor signal transduction histidine kinase OX=862751 OS=Streptomyces sp. SirexAA-E. GN=SACTE_4361 PE=4 SV=1
----------------------WLAFMSAPVRDVVSGDHTVTA-RVLAGLLVF-VAVYLVLRHTSRA---PARRALRSIAVLAVLAVVLSLTLGWLVFVY
VAVAGATLPLRTLIPAATAVMVLIG---LSAGHARIVTALVFPALLGGFAMSGVQQMIR-------TTIELREARATVAQL----AANEERLRLARDLHD
LLGHSLSLITLKSELAGRMLPGRPDRAAEQVADIERVSRQALADVRSAVTGYRRPTLPGE--LAGARTALAA----AGIIADVPTEA-PD-DVPEEQEEV
LAWGLREAVTNVVRHSGARRCSVALTSRQTVVELSVSDDGRGAA--------G----TAGNGLTGIAERLATVDGTLATTTAGPAGFALTLRVP----
>tr|D2SCX1|D2SCX1_GEOOG Integral membrane sensor signal transduction histidine kinase OX=526225 OS=G-20). GN= PE=4 SV=1
----------------------WLLFQFFPVADLVTTDRPLVV-RLVAGLLVF-TVVYLDVRAFGSC---WTGSLLGRLAVVAALGVALAVWMGWAGLIY
VSASAAALPTRWPAVVAAAAVCAAV---LVLHGERGLLILPVLCLLTAFALRGTRHLIS-------VNAELAEAREELARN----AVAEERLRFARDLHD
LLGHSLSLIALKSELAGRLAEADPARARAEMADVEAAARRALAEVRDAVSGYRQVSCAQA--LAEARSALSG----AGIAVRL---A-RVPALPGPVDAA
LGWVVREATTNVLRHSGARSVTVSLTEDGGEAVLTVSDDGRGPA--------D----DPGSGLTGLAERVGALGGALTGGAGRDGGYELRAVLP----
>tr|D3EEC0|D3EEC0_GEOS4 Integral membrane sensor signal transduction histidine kinase OX=481743 OS=Geobacillus sp. (strain Y412MC10). GN= PE=4 SV=1
-------------FNARAAHTIFIVAFFILIMPEYPFLHI---HVLIVYAAFAACYIWM-----AAAPKGWWNAKRCILAGITLIIRIVHSDYDHRIWPL
LYMLGVA-DPKWNRVTLAVFTVCLIL-AMMLVDKVSYGALI-------AAVLMFISLLREAHRTRKQLEQLNTAYSELQQTSMGYAAMTERTRLARDIHD
GFGHQMTSLIVQLQALKLMIPQDPAGAANSVDETLKVARKGMNEVRLAVKEWSDD-EK-G-LGPIALKGLVSQIEANSVQIQYKEIG-PIGEWPVECSVI
LYRILQEALTNILKHADAKTVNIVIEEENEHVKLLITDDGHFSG-QK--------PLNFGFGLSGMIERCKSAGGSIVFSTNSPNGLKIQAVIPLN--
>tr|L5MU06|L5MU06_9BACL Two-component sensor histidine kinase OX=1246477 OS=Brevibacillus agri BAB-2500. GN=D478_11794 PE=4 SV=1
-------------IQKRLLIIWFSILIVLAL-DSFMRETP---LQFSLTIVLFFCYIVV-----FWISKRNWKPYQVMLGTMALLKSVFAGGEFGMMLPL
AVFIGYIE--------FFG-----------------------------ILIGCYIRIQSEAYKTQAHLEELQEAHSQLQEAALQVAVLEERTRIARDIHD
ALGHSLTSLIVQLHALKYMLQDGPEHAQEAVRNMLGVAKQSLEEIRTSVHTLAMD-KT-S-LGLTPLRALLSQAQKHTIKMELISSE-LDIPLSQELTIT
FYRILQEAITNTLRHSNAKEIQVMIEQREGSLYFSIQDDGDITP-QD--------QIKPGFGLTGIAERIKQLNGSLSYSAKEPHGFKLDVRLPLE--
>tr|J2GJL6|J2GJL6_9BACL Signal transduction histidine kinase OX=1144308 OS=Brevibacillus sp. BC25. GN=PMI05_04866 PE=4 SV=1
-------------IQKRLLIMWFSILIVLAL-DSFKRETP---LQFSLTIVLFICYLVV-----FWTSKKKWKPFQVVLGIVSLLKSLILGGEFGLMLPL
AVFIGHIH--------FFG-----------------------------ILVGCYIRIQTEAYETQQHLEQLQEAHLQLQEAALQVAVLEERTRIARDIHD
ALGHSLTSLIVQLHALKYMLQDGPDNAQEAVRNMLGVAKQSLEDIRTSVHTLALD-KT-S-LGLTPLRALLSQAQKHTIKMELMCSD-LDIPLSQEMTIT
FYRILQEAITNSLRHSDAKEILVIIEQKKDILLLSIRDDGSITS-DQ--------KIKPGFGLTGISERIQLLNGTLAYRIREPHGFQLDFSFPIG--
>tr|J8F6F0|J8F6F0_BACCE Uncharacterized protein OX=1053220 OS=Bacillus cereus MSX-A1. GN= PE=4 SV=1
-------------ILQKVFKVIISIAGFVFYYRYFSTQGQ---LSLMICICYIIIYLFM-----LWIPKYWWSPSKSLLIGTVLVIHLLMEFEAKLLWPL
VCLLAIS-PVKFIVSLQALLAIGVIL-EISWINNFPYANLF-------GLGGLYVSLLREAYQIQEQFIELEATHAELQEATMKYAALTERTRIARDIHD
GLGHQMTSLVVQLQALELMLPNDPQTATKTVNQLLKIARSGMEEIRVTVHEWASD-EK-G-LGIIAIRGFISQTASNSIKFHLKEEG-GFSEWNEDISIT
IFRVLQEAITNVIRHSGANEVEICIQENDQKISLVVSDNGRFIN-TS--------SFQNGFGVKGMIERCQSIGGTCTFSASKEGGLKIKIIIPIE--
>tr|K6UBQ4|K6UBQ4_9CLOT Signal transduction histidine kinase OX=1196322 OS=Clostridium sp. Maddingley MBC34-26. GN=A370_00837 PE=4 SV=1
-------------ILGLHFYSVFAIIAFIFYHRVFENVRG---MPLIVCIVILFFEIVL-----IWSKKTKWNSMTIFIIAMGMILQYCYGVESTILWPL
IWAFGVM-PGTYNNVVLAFLTTVLIL-IMSYTFPFPFGTLF-------NLVGVYLRIRQEAYRTQLHLSELNEAHAELQEASMRYAALEERTRLAREIHD
GIGHQLTSLIVQLQALEIMLPQDPGKASELVSQLLKISRQTMAEVRVAVKEWSDD-EM-G-LGLIALKGLISQTQARSIQFSFIQES-EITEWPIEISIV
LYRILQESLTNILRHSNAISVEVRIKETNDQVVLIVSDNGRYTE-NT--------PLTPGFGIKGIMERCKLQGGTCNIIPERPHGLRVEVILPIE--
>tr|J2H447|J2H447_9BACL Signal transduction histidine kinase OX=1144308 OS=Brevibacillus sp. BC25. GN=PMI05_01276 PE=4 SV=1
-------------LRSRFLLICFFVLISFFL-NAYMHEPT---IPFIITLIIIFCFLLM-----FLRPQKNWRPFQIVLGTVSFIKVLYVGEEIGLSLPL
VAFIGHIL--------FFG-----------------------------IVIGWYISLQNQAKEAQQHLKQLQEAHSELQAASLRAAVLEERTRIARDVHD
ALGHSLTSLIVQLNALKYMLQGGPSDAQEAVRDMLSVSKQSLDDIRSSVHTLAAD-KS-S-LGITPLRILLSRAQQHTIKMHLISPN-PDIPLSQQMTIT
LYRILQEAITNSIRHSDATEIFITIEKKQNFIFLSIWDNGNITN-HH--------QIKLGSGLTGIAEQTKQLNGDLSYSIRAPHGFQIDISFPL---
>tr|C2YIY3|C2YIY3_BACCE Histidine kinase dimerization and phosphoacceptor region containing protein OX=526991 OS=Bacillus cereus AH676. GN= PE=4 SV=1
-------------IDSHAGNAIGSILICVFFYKGFAPYGT---FAIWVCSVFVSIYLWM-----LYSPKSWWNAGRSILISLSCVLYFSHPSFNYALWPL
IGFLAAA-EPKWTRKILAAITGIVII-LLLHANTFPYQETL-------IIIGLYVSKLKEAYQKQKQLKELDEAHAELQETTMQYAAFAERTKLAREIHD
GLGHQMTSLIIQLQALKIMLRKNPAAAQDHVEELLKVARKGMEEIRVAVKEWTSD-EK-D-LGLTSLKGLISQVQANSLQIEFIQAG-SITEWSMEESTI
LYRILQESLTNVLRHSYADSVIVNVTEINGVVKLTIDDNGIYTG-DK--------PLKYGFGLNGMIKRCQSVGGNCSFSLNEPKGLRVEAIIPIQ--
>tr|J7WX39|J7WX39_BACCE Uncharacterized protein OX=1053183 OS=Bacillus cereus BAG3X2-1. GN= PE=4 SV=1
-------------IGSHVGNAIGSILLCLFFYKGFAPYGT---FAIWVCSIFVAIYLWM-----LNAPKYRWNEIKSVLVILSCIVHFFYPGYNFVLLPL
LIFLAAA-EPKWARTVLSAITGIILI-LFISSSMFPYQEIL-------MITGIYVSKLKEAYQKQKQLKELDEAHAELQETTMRYAAFAERTKLAREIHD
GLGHQMTSLIIQLQALKIMLKKNPSAAHDSVDDLLKVARKGMEEIRTAVREWTSD-EK-D-LGLTSLKGLISQVQANSLQIEFIHSE-KISEWTMEESTI
LYRILQESLTNILRHSHADSVIVSVTEIDGVVKLSVADNGIFMG-DK--------ELEFGFGLNGMIKRCESVGGSCSFTLNEPKGLRVEARIPIH--
>tr|G0FMG8|G0FMG8_AMYMD Two-component system histidine kinase OX=713604 OS=Amycolatopsis mediterranei S699. GN= PE=4 SV=1
----------------------------------------------------AFAVGYLLAAAAAARRAA-RPFWLGGCAVLFAVAIPFAHADAFLAAVV
LSLAVPRLPRRVAFGLVAAAALAAVLGPWP--GGPGWTQ-----AVALVFTVLMVSAFAEAIRAN---TALVEARAEV---AR-LASEAERTRIARDLHD
LLGHSLTAITVKSTLARRLVTAEAARAGEEMAAVETLARQALTDVRAAVSGYREVTLA-G-ELARGRELLRACGVAADLPTATDVVGS--------AHQE
LFGVVREGLTNVARHARATRCSVTLS----ASTVEVVDDGVGG-------AA-----SGGSGLDGLRERVLAAGGGFSAGPLHPRGWRLRVTV-----
>tr|C5C4C1|C5C4C1_BEUC1 Histidine kinase OX=471853 OS=Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432). GN= PE=4 SV=1
--------------------------------------------IWWACYVGYLVALVVSSFQHEVRRRVALAAFGAQVAFGIV-LVASAPGAGWTPILL
VYTAAALVRWRTTAAVVVANSATVAFTAWAATGQ---------VLDAVLGGGLYTAQLREVEMRSALAVELRATSTLLASA----TRADERLRIARELHD
AVGHQLTVLALELEIAS-HR--SAPPAAEHVVRARGIARDLLADVRQVVGELRERA----PDLRRTLASLVADL--PAPRVHLDVA--DDVEADEIRTIA
LVRCVQEVVTNAIRHSGAEHLWIEVRLGDGALVLEASDDGRGAERI-----------VVGNGLRGLAERVADLGGEATFSA--RGGFHVRARVPA---
>tr|F6EHH8|F6EHH8_AMYSD Histidine kinase OX=443218 OS=Amycolicicoccus subflavus (strain DSM 45089 / DQS3-9A1). GN= PE=4 SV=1
--------------------------------------------LWWVVAFAAMLGAALAAFAFEHRTGPRHLALGTAVAASWI-VVAGAPSLGFLPILL
IAMAALTTRLAGTAFIVMLNTLVIGAIAVRYSDS---------LQEAAIVTGLYLAITREQQLRRQLTEELRAATALLAES----ARTSERLRISRDLHD
TIGHQLTVLSLELEAAR-HR--EGSRAREHVERAQSVARDLLRDVRSTVGELRNGS----ADLAATLSEIVKDL--PGLNISVEVE--PAVEVGEDESTA
LILAVQEIITNTIRHASARELWIEIARDTGATVLTAADDGRGADSL-----------VLGNGLRGMKERFEEIGGNVRIGGLAGRGLTITARVPA---
>tr|F4FD29|F4FD29_VERMA Histidine kinase OX=263358 OS=Verrucosispora maris (strain AB-18-032). GN= PE=4 SV=1
--------------------------------------------GWWLALFVLLLAALLTATAAPEQGRSRYVAYGVAVVAAWT-LVLTARHLGLLPVLL
VLTAAVVVPLSVGLTVVGLNTAVIILVAVPTTRT---------PAELTLIVGFYLTLLREQRMRRELAAELKAAGLRLEES----ARTEERLRISRELHD
LIGHQLTVLTLELETAR-HR--DGAAAREHVERADRVARDLLGDVRATVGQLRTET----VDLGQALRRMARDL--PGLDVSIDVS--ADVQVDEERAAA
FVRAAQEIITNTIRHAEAQRLRISVTGDGGAAVLDAHDDGRGARRP-----------TFGNGLRGLRERFEALGGEVVIDG--SAGFRVTARVPT---
>tr|F3NML7|F3NML7_9ACTO Two-component system sensor kinase OX=996637 OS=Streptomyces griseoaurantiacus M045. GN=SGM_4381 PE=4 SV=1
--------------------GIWLVFLNSPFLDLFSGEHSTATAGGWLGLTVF-VGLYLALVSREGRAFPRWLHGIIAALGALAVLLTLTLGSHWVGLFV
YVACGLALPLRAAYWAVPGTTALMALVVAYVDLD-QLSSMVLLTLLIGFAMTSVSQLVR-------TTIELRRARATVA----RLAANEERLRLARDLHD
LLGHSLSLITLKSELAGRMLPAHPDKAAQQVADIESVSRQALVDVREAVSGYRRPRLAEE--LAGAQVAL----AAAGVTADLPAEPALDG-VPEERESA
LAWALREAVTNVVRHSGARRCAVSLILDGPVLELSVEDDGPGGSGG-----------GHGNGLTGLTERLQKVGGSLETGR-VGRGYRLVARVPA---
>tr|H2K0H0|H2K0H0_STRHJ Two-component system sensor kinase OX=1133850 OS=Streptomyces hygroscopicus subsp. jinggangensis (strain 5008). GN= PE=4 SV=1
--------------------GVWLVFLSSPVGDLVGGHHTARTLAGSLGLAAF-VGVYLALVFRNGRSFAPRTVGLIAVLAVLAPVLAYTLGSAWLGLFV
YLACGATLPVRASYWAIPATAALMYLVGLHSNEK-EARGLLLLVGLIGFAMVGVGQLVR-------TTIELRKARATVA----QLAANEERLRLARDLHD
LLGHSLSLITLKSELAGRMLPGHPDKAAQQVADIEQVSRQALVDVREAVTGYRRPRLAAE--LAGAQVAL----TAAGVVAEVPAEPDLAG-VPEEAESA
LAWALREAVTNVVRHSGADRCVVRLLLDGPVLELSVEDSGSGGSGK-----------GPGNGLTGLTERLEKAGGSLEAGR-VGHGFRLVARVP----
>tr|L7FBY3|L7FBY3_9ACTO Histidine kinase OX=698760 OS=Streptomyces turgidiscabies Car8. GN=STRTUCAR8_07242 PE=4 SV=1
--------------------GVWLAYLGAPADDLLHGGHSTGQFLGWLGLVVF-VAYYAALVFRTGRGETTRLVVSLALLAVQSTVLALSLGREWLVLFV
YVSSGAALPLRMSRWAIAANAALMTAVALAVPGG-HSAGLIVPALLGGAAMAGVRQLVR-------TTIELREARATVA----QLAANEERLRLARDLHD
LLGHSLSLITLKSELAGRMLPAHPEKAAQQVADIEQVSRQALVDVREAVSGYRRPRLAGE--LAGAQVAL----TAAGIAAALPEDAVAADAVDEDAEAA
LAWALREAVTNVVRHSGAGRCTVEVLLDGPVLELSVEDDGSGGGSA-----------GPGNGLTGLAERLEKAGGSLETSR-TKRGFRLVARVPM---
>tr|D6JZU5|D6JZU5_9ACTO Two-component system sensor kinase OX=645465 OS=Streptomyces sp. e14. GN=SSTG_03223 PE=4 SV=1
--------------------GVWLVFLSSPVHDLAAGNHSAARVGGWTGLAVF-VAAYLALVFRNGRPFRRRTVSLIVFLGALAVLLCLTLGPAWLGLFC
YVACGATLPVRAAYGAIPATAAVMVLTGLGTDVA-DARSLVLLVLLIGFAMVGVSQLVR-------TTIELREARATVA----QLAANEERLRLARDLHD
LLGHSLSLITLKSELAGRMLPGHPDKAAQQVADIEQVSRQALVDVREAVTGYRRPRLAAE--LAGARVAL----TAAGVEARLPAEPGLDD-VPEESESA
LAWALREAVTNVVRHSGARWCAVDLVLDGPVLELSVEDDGQGGAGG-----------LPGNGLTGLSERLQKAGGMLEAGR-LKRGFRLVARVPR---
>tr|J9HHA7|J9HHA7_9BACL Histidine kinase OX=1200346 OS=Alicyclobacillus hesperidum URH17-3-68. GN=URH17368_0072 PE=4 SV=1
------------------------------------------------FMMLIFGIAYACTFRAEERPRVRLLGCFIMVALLWTMMATFSLNFIYLAYPV
AGL--ATFPLRKNLLLYVACLTGTIALDMSLGQPLPA-HFAYALAGLVFITSTMIFMLRWHHQVRAMNEQLAVAHEEIARLS----KQAERARISRDLHD
VMGHQLSLISLKAQVAARVLRGDADRVLMEIELIERSARESLGKVRDYVANMRQPDFFEE--WQS-ARTL---LDAAGIVVTME------------AEQT
FAMCLRETVTNVVRHSQASRCAIFLRQTGGVVWMAIADDGRGLVQYRDL---RP-DGTGCNGIAGIKARVERLAGTCHVFSQTQIGCCVVVSAPT---
>tr|F8IDB5|F8IDB5_ALIAT Histidine kinase OX=1048834 OS=acidocaldarius). GN= PE=4 SV=1
------------------------------------------------GSLAAFGALYVVAFLTPRNSPWRIAAFFGQLAILLTLMAAFSLNYVYLLFPV
ATI--LYGPLRRTMALFVVLCASVGAVERAHHIPFPQ-GFHYLLIGALFGGSILIYMMRAWAALEQTNARLQAAQSEIARLS----QAEERARIGRDLHD
LLGHQLSLITLKAQVAGRILEGDVPRARDEIEQIERVSRATLESVRAYVADMRATDWQDA--WRA-AEEV---LAAAGIEAHMACEM--DA-VPKTVEHA
YAMCLREAVTNVVRHSGARRCAVRMWRDGPLVVLAVADDGEGAAEFATIP-T-----CGGSGIAGMRARMAQIGGECERLGRDEPGWVVVLKAPV---
>tr|K6WME3|K6WME3_9MICO Putative two-component histidine kinase OX=1184609 OS=Kineosphaera limosa NBRC 100340. GN=KILIM_015_00260 PE=4 SV=1
-----------------AYAIAFLVFLAFPAVELWSEGGW--RAAVGLPLLALFVLAYAGGRLLGMRAFRGPWPWLIGLTALAAGLTAILPGLT-CLTYV
AAGAGATLPTRQSLSAIAACGMAMFIGTLAYTGSWLWASGL--AFWTAIIVWGSVAMSRH-------SDALTRAREEKA----ELAVELERTRLARDLHD
ILGHSLTVITVKAELAGRLIDTDPAQAKAEIIDLERLARDALADVRTTVSGYRQLSL------PTELIRARKALQSAGI--TARVPGAADL-VDTRLRDL
FAWVVREGVTNVVRHSGASTCEITLGAD----EVVVRDDGTGPGGEM----------EPGNGLTGLRERARQVGAQATAGRAADGGFELCVRA-----