| ABCA4_923_1909 -force run |
| ID: | 1492907188 |
Query Sequence |
Download Alignment We filter this alignment to remove positions that have > 50% gaps before running GREMLIN. |
| Length: | 987 (977) | ||
| Sequences: | 269 (153.8) | ||
| Seq/Len: | 0.275 | ||
| Nf(neff/√len): | 4.9 |
Jackhmmer Results: (2016_04)
Sequences per length for each position, BEFORE the coverage/gap filter was applied
Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 0.275).
Sequences per length for each position, AFTER the coverage/gap filter was applied
Residue pairs sorted by coevolution strength:
Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.
| i | j | Scaled score | Prob |
| 566_C | 570_T | 2.238 | 0.82 |
| 51_L | 194_S | 2.193 | 0.80 |
| 329_E | 340_F | 2.175 | 0.79 |
| 31_F | 192_I | 1.971 | 0.69 |
| 921_R | 925_D | 1.932 | 0.67 |
| 321_Y | 325_F | 1.911 | 0.66 |
| 267_P | 271_D | 1.869 | 0.63 |
| 194_S | 805_N | 1.852 | 0.62 |
| 54_L | 65_V | 1.843 | 0.62 |
| 880_I | 914_F | 1.814 | 0.60 |
| 930_Q | 934_D | 1.808 | 0.59 |
| 851_A | 960_M | 1.804 | 0.59 |
| 16_F | 38_A | 1.780 | 0.58 |
| 194_S | 715_A | 1.775 | 0.57 |
| 766_F | 780_I | 1.758 | 0.56 |
| 40_L | 44_G | 1.743 | 0.55 |
| 880_I | 913_V | 1.726 | 0.54 |
| 265_T | 269_H | 1.717 | 0.53 |
| 135_E | 139_D | 1.694 | 0.52 |
| 38_A | 598_E | 1.682 | 0.51 |
| 262_F | 265_T | 1.674 | 0.51 |
| 953_I | 957_L | 1.668 | 0.50 |
| 65_V | 162_I | 1.655 | 0.49 |
| 265_T | 271_D | 1.648 | 0.49 |
| 520_N | 523_L | 1.647 | 0.49 |
| 703_H | 870_Y | 1.633 | 0.48 |
| 180_D | 342_I | 1.591 | 0.45 |
| 454_Q | 703_H | 1.570 | 0.44 |
| 464_L | 734_V | 1.565 | 0.44 |
| 715_A | 870_Y | 1.565 | 0.44 |
| 287_M | 309_F | 1.564 | 0.43 |
| 454_Q | 870_Y | 1.543 | 0.42 |
| 202_D | 222_P | 1.539 | 0.42 |
| 40_L | 43_N | 1.530 | 0.41 |
| 197_H | 307_L | 1.525 | 0.41 |
| 268_A | 271_D | 1.524 | 0.41 |
| 861_F | 971_T | 1.521 | 0.41 |
| 170_V | 178_I | 1.518 | 0.41 |
| 878_L | 882_I | 1.512 | 0.40 |
| 481_L | 488_Y | 1.506 | 0.40 |
| 821_V | 903_F | 1.489 | 0.39 |
| 519_G | 522_C | 1.484 | 0.38 |
| 215_R | 851_A | 1.481 | 0.38 |
| 262_F | 267_P | 1.478 | 0.38 |
| 126_D | 184_K | 1.477 | 0.38 |
| 910_L | 948_F | 1.468 | 0.37 |
| 454_Q | 787_S | 1.465 | 0.37 |
| 522_C | 731_G | 1.465 | 0.37 |
| 40_L | 45_A | 1.460 | 0.37 |
| 432_H | 800_T | 1.459 | 0.37 |
| 65_V | 157_D | 1.456 | 0.37 |
| 58_L | 215_R | 1.455 | 0.37 |
| 97_T | 100_E | 1.444 | 0.36 |
| 764_V | 824_F | 1.443 | 0.36 |
| 289_V | 466_L | 1.441 | 0.36 |
| 159_K | 451_F | 1.439 | 0.36 |
| 856_M | 877_N | 1.410 | 0.34 |
| 229_F | 936_Y | 1.406 | 0.34 |
| 67_V | 366_G | 1.394 | 0.33 |
| 54_L | 80_R | 1.393 | 0.33 |
| 764_V | 890_I | 1.388 | 0.33 |
| 801_Y | 809_D | 1.388 | 0.33 |
| 43_N | 49_T | 1.387 | 0.33 |
| 39_F | 50_T | 1.387 | 0.33 |
| 267_P | 270_V | 1.379 | 0.32 |
| 12_L | 39_F | 1.378 | 0.32 |
| 290_V | 309_F | 1.377 | 0.32 |
| 106_A | 116_A | 1.375 | 0.32 |
| 146_R | 179_W | 1.374 | 0.32 |
| 708_F | 739_L | 1.374 | 0.32 |
| 442_Q | 640_I | 1.372 | 0.32 |
| 16_F | 99_A | 1.372 | 0.32 |
| 521_R | 597_T | 1.369 | 0.32 |
| 53_I | 294_V | 1.369 | 0.32 |
| 269_H | 272_D | 1.368 | 0.31 |
| 705_L | 868_T | 1.364 | 0.31 |
| 124_L | 321_Y | 1.352 | 0.31 |
| 52_S | 57_L | 1.347 | 0.30 |
| 38_A | 99_A | 1.341 | 0.30 |
| 290_V | 734_V | 1.339 | 0.30 |
| 308_I | 939_F | 1.335 | 0.30 |
| 267_P | 273_L | 1.329 | 0.29 |
| 45_A | 48_T | 1.322 | 0.29 |
| 870_Y | 883_N | 1.321 | 0.29 |
| 14_K | 40_L | 1.320 | 0.29 |
| 14_K | 44_G | 1.320 | 0.29 |
| 353_K | 697_F | 1.318 | 0.29 |
| 150_V | 321_Y | 1.316 | 0.29 |
| 198_M | 226_K | 1.306 | 0.28 |
| 252_E | 256_S | 1.304 | 0.28 |
| 357_D | 613_V | 1.301 | 0.28 |
| 516_P | 520_N | 1.300 | 0.28 |
| 255_C | 259_S | 1.295 | 0.27 |
| 865_V | 871_V | 1.294 | 0.27 |
| 256_S | 266_C | 1.292 | 0.27 |
| 262_F | 270_V | 1.290 | 0.27 |
| 42_H | 50_T | 1.287 | 0.27 |
| 611_F | 619_L | 1.284 | 0.27 |
| 329_E | 761_A | 1.283 | 0.27 |
| 13_V | 870_Y | 1.279 | 0.27 |
| 770_F | 808_W | 1.277 | 0.27 |
| 36_I | 182_L | 1.275 | 0.26 |
| 697_F | 811_M | 1.273 | 0.26 |
| 900_L | 952_L | 1.269 | 0.26 |
| 588_P | 870_Y | 1.267 | 0.26 |
| 906_V | 910_L | 1.266 | 0.26 |
| 120_M | 205_G | 1.265 | 0.26 |
| 853_I | 960_M | 1.262 | 0.26 |
| 468_L | 926_L | 1.261 | 0.26 |
| 39_F | 79_V | 1.260 | 0.26 |
| 610_D | 614_K | 1.259 | 0.26 |
| 771_V | 817_A | 1.254 | 0.25 |
| 893_L | 975_Q | 1.253 | 0.25 |
| 87_P | 98_V | 1.252 | 0.25 |
| 772_P | 848_Y | 1.249 | 0.25 |
| 703_H | 787_S | 1.242 | 0.25 |
| 734_V | 786_K | 1.239 | 0.25 |
| 40_L | 49_T | 1.237 | 0.25 |
| 44_G | 49_T | 1.237 | 0.25 |
| 12_L | 42_H | 1.237 | 0.25 |
| 183_L | 722_P | 1.231 | 0.24 |
| 799_T | 894_F | 1.231 | 0.24 |
| 866_P | 891_L | 1.228 | 0.24 |
| 350_I | 851_A | 1.228 | 0.24 |
| 43_N | 48_T | 1.226 | 0.24 |
| 267_P | 272_D | 1.225 | 0.24 |
| 486_W | 695_V | 1.224 | 0.24 |
| 56_G | 86_C | 1.224 | 0.24 |
| 198_M | 202_D | 1.223 | 0.24 |
| 808_W | 812_N | 1.222 | 0.24 |
| 350_I | 357_D | 1.219 | 0.24 |
| 455_I | 806_F | 1.218 | 0.24 |
| 840_A | 917_F | 1.216 | 0.24 |
| 322_A | 480_A | 1.215 | 0.24 |
| 61_T | 104_F | 1.213 | 0.23 |
| 259_S | 267_P | 1.212 | 0.23 |
| 462_V | 473_P | 1.211 | 0.23 |
| 256_S | 259_S | 1.210 | 0.23 |
| 151_A | 154_F | 1.210 | 0.23 |
| 926_L | 972_L | 1.204 | 0.23 |
| 264_T | 273_L | 1.203 | 0.23 |
| 802_W | 809_D | 1.202 | 0.23 |
| 14_K | 36_I | 1.200 | 0.23 |
| 83_L | 290_V | 1.199 | 0.23 |
| 21_R | 796_V | 1.198 | 0.23 |
| 11_N | 796_V | 1.196 | 0.23 |
| 94_H | 709_L | 1.196 | 0.23 |
| 12_L | 79_V | 1.194 | 0.23 |
| 65_V | 222_P | 1.193 | 0.22 |
| 177_S | 872_A | 1.193 | 0.22 |
| 772_P | 823_I | 1.191 | 0.22 |
| 265_T | 270_V | 1.190 | 0.22 |
| 563_S | 589_P | 1.187 | 0.22 |
| 437_L | 807_L | 1.187 | 0.22 |
| 299_L | 465_A | 1.187 | 0.22 |
| 186_R | 748_E | 1.185 | 0.22 |
| 211_I | 598_E | 1.184 | 0.22 |
| 495_F | 705_L | 1.184 | 0.22 |
| 760_V | 763_C | 1.181 | 0.22 |
| 922_G | 940_G | 1.181 | 0.22 |
| 56_G | 84_G | 1.180 | 0.22 |
| 37_T | 43_N | 1.179 | 0.22 |
| 478_Y | 883_N | 1.178 | 0.22 |
| 56_G | 87_P | 1.178 | 0.22 |
| 254_T | 262_F | 1.178 | 0.22 |
| 229_F | 516_P | 1.178 | 0.22 |
| 522_C | 718_R | 1.177 | 0.22 |
| 103_L | 205_G | 1.177 | 0.22 |
| 862_L | 958_F | 1.177 | 0.22 |
| 253_G | 258_S | 1.175 | 0.22 |
| 782_E | 796_V | 1.175 | 0.22 |
| 257_C | 260_K | 1.172 | 0.22 |
| 150_V | 953_I | 1.171 | 0.21 |
| 233_L | 319_R | 1.171 | 0.21 |
| 346_P | 810_I | 1.169 | 0.21 |
| 520_N | 596_S | 1.169 | 0.21 |
| 878_L | 971_T | 1.166 | 0.21 |
| 329_E | 927_A | 1.166 | 0.21 |
| 929_S | 947_P | 1.165 | 0.21 |
| 101_H | 172_P | 1.163 | 0.21 |
| 14_K | 23_A | 1.163 | 0.21 |
| 58_L | 297_A | 1.163 | 0.21 |
| 104_F | 119_E | 1.162 | 0.21 |
| 870_Y | 882_I | 1.161 | 0.21 |
| 80_R | 88_Q | 1.161 | 0.21 |
| 734_V | 965_V | 1.160 | 0.21 |
| 262_F | 266_C | 1.159 | 0.21 |
| 324_L | 443_H | 1.158 | 0.21 |
| 850_W | 964_G | 1.158 | 0.21 |
| 286_L | 495_F | 1.158 | 0.21 |
| 161_V | 435_A | 1.156 | 0.21 |
| 871_V | 885_S | 1.155 | 0.21 |
| 795_G | 802_W | 1.154 | 0.21 |
| 299_L | 817_A | 1.154 | 0.21 |
| 203_L | 597_T | 1.152 | 0.21 |
| 918_C | 924_I | 1.151 | 0.21 |
| 239_R | 346_P | 1.151 | 0.21 |
| 83_L | 110_G | 1.149 | 0.21 |
| 350_I | 880_I | 1.148 | 0.20 |
| 518_F | 552_F | 1.148 | 0.20 |
| 255_C | 260_K | 1.147 | 0.20 |
| 588_P | 739_L | 1.146 | 0.20 |
| 124_L | 202_D | 1.145 | 0.20 |
| 265_T | 268_A | 1.145 | 0.20 |
| 853_I | 870_Y | 1.143 | 0.20 |
| 14_K | 27_L | 1.142 | 0.20 |
| 123_M | 202_D | 1.141 | 0.20 |
| 186_R | 451_F | 1.141 | 0.20 |
| 57_L | 152_I | 1.139 | 0.20 |
| 490_Q | 894_F | 1.137 | 0.20 |
| 173_Y | 198_M | 1.137 | 0.20 |
| 342_I | 534_G | 1.137 | 0.20 |
| 780_I | 871_V | 1.137 | 0.20 |
| 624_L | 627_K | 1.136 | 0.20 |
| 267_P | 274_T | 1.136 | 0.20 |
| 150_V | 461_F | 1.134 | 0.20 |
| 265_T | 272_D | 1.134 | 0.20 |
| 786_K | 796_V | 1.134 | 0.20 |
| 835_P | 865_V | 1.134 | 0.20 |
| 257_C | 261_G | 1.133 | 0.20 |
| 261_G | 264_T | 1.132 | 0.20 |
| 12_L | 45_A | 1.131 | 0.20 |
| 940_G | 960_M | 1.131 | 0.20 |
| 7_V | 45_A | 1.130 | 0.20 |
| 713_H | 831_A | 1.130 | 0.20 |
| 838_L | 845_L | 1.130 | 0.20 |
| 65_V | 68_G | 1.130 | 0.20 |
| 122_A | 180_D | 1.130 | 0.20 |
| 16_F | 975_Q | 1.130 | 0.20 |
| 754_T | 894_F | 1.129 | 0.20 |
| 813_Y | 845_L | 1.129 | 0.20 |
| 214_G | 220_G | 1.128 | 0.20 |
| 254_T | 259_S | 1.127 | 0.20 |
| 73_E | 598_E | 1.126 | 0.20 |
| 216_L | 332_L | 1.124 | 0.19 |
| 120_M | 859_A | 1.124 | 0.19 |
| 602_D | 715_A | 1.124 | 0.19 |
| 425_G | 973_L | 1.124 | 0.19 |
| 790_L | 801_Y | 1.123 | 0.19 |
| 145_Q | 697_F | 1.123 | 0.19 |
| 119_E | 126_D | 1.123 | 0.19 |
| 856_M | 873_L | 1.123 | 0.19 |
| 222_P | 597_T | 1.120 | 0.19 |
| 205_G | 831_A | 1.120 | 0.19 |
| 813_Y | 973_L | 1.118 | 0.19 |
| 268_A | 274_T | 1.117 | 0.19 |
| 261_G | 268_A | 1.117 | 0.19 |
| 69_G | 84_G | 1.117 | 0.19 |
| 24_V | 36_I | 1.117 | 0.19 |
| 71_D | 80_R | 1.117 | 0.19 |
| 149_S | 827_F | 1.116 | 0.19 |
| 396_N | 401_G | 1.115 | 0.19 |
| 33_E | 50_T | 1.114 | 0.19 |
| 67_V | 154_F | 1.113 | 0.19 |
| 91_I | 222_P | 1.111 | 0.19 |
| 252_E | 258_S | 1.111 | 0.19 |
| 65_V | 286_L | 1.111 | 0.19 |
| 684_L | 842_V | 1.111 | 0.19 |
| 252_E | 264_T | 1.111 | 0.19 |
| 105_Y | 176_R | 1.111 | 0.19 |
| 210_I | 786_K | 1.110 | 0.19 |
| 61_T | 792_F | 1.108 | 0.19 |
| 51_L | 65_V | 1.108 | 0.19 |
| 269_H | 273_L | 1.108 | 0.19 |
| 586_G | 780_I | 1.108 | 0.19 |
| 152_I | 437_L | 1.108 | 0.19 |
| 151_A | 181_L | 1.107 | 0.19 |
| 354_V | 794_S | 1.106 | 0.19 |
| 262_F | 271_D | 1.105 | 0.19 |
| 614_K | 780_I | 1.105 | 0.19 |
| 215_R | 264_T | 1.104 | 0.19 |
| 36_I | 738_P | 1.104 | 0.19 |
| 261_G | 265_T | 1.102 | 0.19 |
| 261_G | 267_P | 1.102 | 0.19 |
| 290_V | 722_P | 1.101 | 0.19 |
| 350_I | 963_E | 1.100 | 0.19 |
| 923_L | 964_G | 1.099 | 0.18 |
| 52_S | 110_G | 1.098 | 0.18 |
| 180_D | 315_N | 1.098 | 0.18 |
| 205_G | 208_I | 1.097 | 0.18 |
| 197_H | 521_R | 1.096 | 0.18 |
| 598_E | 693_I | 1.096 | 0.18 |
| 14_K | 43_N | 1.096 | 0.18 |
| 76_L | 793_I | 1.095 | 0.18 |
| 50_T | 54_L | 1.093 | 0.18 |
| 918_C | 956_N | 1.093 | 0.18 |
| 254_T | 268_A | 1.092 | 0.18 |
| 141_S | 146_R | 1.088 | 0.18 |
| 14_K | 48_T | 1.088 | 0.18 |
| 345_T | 353_K | 1.086 | 0.18 |
| 466_L | 820_V | 1.085 | 0.18 |
| 126_D | 354_V | 1.085 | 0.18 |
| 74_T | 229_F | 1.085 | 0.18 |
| 106_A | 697_F | 1.085 | 0.18 |
| 97_T | 101_H | 1.085 | 0.18 |
| 342_I | 479_P | 1.084 | 0.18 |
| 224_F | 789_H | 1.082 | 0.18 |
| 28_N | 186_R | 1.082 | 0.18 |
| 56_G | 88_Q | 1.082 | 0.18 |
| 148_L | 167_T | 1.082 | 0.18 |
| 208_I | 222_P | 1.080 | 0.18 |
| 557_W | 708_F | 1.080 | 0.18 |
| 132_K | 181_L | 1.079 | 0.18 |
| 737_Q | 794_S | 1.079 | 0.18 |
| 254_T | 407_P | 1.079 | 0.18 |
| 290_V | 761_A | 1.079 | 0.18 |
| 85_M | 130_H | 1.079 | 0.18 |
| 264_T | 267_P | 1.079 | 0.18 |
| 67_V | 79_V | 1.079 | 0.18 |
| 248_R | 255_C | 1.079 | 0.18 |
| 40_L | 48_T | 1.079 | 0.18 |
| 44_G | 48_T | 1.079 | 0.18 |
| 115_E | 704_A | 1.078 | 0.18 |
| 9_V | 34_N | 1.078 | 0.18 |
| 143_G | 163_L | 1.077 | 0.18 |
| 260_K | 268_A | 1.077 | 0.18 |
| 900_L | 917_F | 1.076 | 0.18 |
| 769_S | 774_S | 1.075 | 0.18 |
| 66_L | 552_F | 1.074 | 0.17 |
| 461_F | 837_N | 1.074 | 0.17 |
| 147_K | 173_Y | 1.074 | 0.17 |
| 53_I | 132_K | 1.073 | 0.17 |
| 141_S | 179_W | 1.073 | 0.17 |
| 256_S | 269_H | 1.073 | 0.17 |
| 173_Y | 794_S | 1.071 | 0.17 |
| 107_Q | 697_F | 1.070 | 0.17 |
| 844_L | 922_G | 1.069 | 0.17 |
| 342_I | 548_I | 1.069 | 0.17 |
| 251_S | 259_S | 1.069 | 0.17 |
| 27_L | 157_D | 1.069 | 0.17 |
| 772_P | 779_L | 1.068 | 0.17 |
| 262_F | 268_A | 1.068 | 0.17 |
| 433_V | 468_L | 1.068 | 0.17 |
| 35_Q | 87_P | 1.068 | 0.17 |
| 611_F | 682_D | 1.068 | 0.17 |
| 90_N | 132_K | 1.068 | 0.17 |
| 542_P | 577_L | 1.067 | 0.17 |
| 684_L | 855_M | 1.067 | 0.17 |
| 596_S | 600_L | 1.066 | 0.17 |
| 790_L | 809_D | 1.066 | 0.17 |
| 260_K | 384_P | 1.065 | 0.17 |
| 924_I | 931_A | 1.065 | 0.17 |
| 76_L | 83_L | 1.064 | 0.17 |
| 522_C | 568_C | 1.064 | 0.17 |
| 586_G | 614_K | 1.063 | 0.17 |
| 564_P | 585_G | 1.063 | 0.17 |
| 253_G | 271_D | 1.062 | 0.17 |
| 127_T | 194_S | 1.061 | 0.17 |
| 262_F | 269_H | 1.061 | 0.17 |
| 464_L | 697_F | 1.061 | 0.17 |
| 888_T | 954_G | 1.061 | 0.17 |
| 193_M | 492_Y | 1.061 | 0.17 |
| 59_P | 900_L | 1.061 | 0.17 |
| 106_A | 202_D | 1.061 | 0.17 |
| 8_C | 30_T | 1.060 | 0.17 |
| 757_D | 868_T | 1.060 | 0.17 |
| 154_F | 347_L | 1.059 | 0.17 |
| 904_N | 908_R | 1.059 | 0.17 |
| 313_N | 321_Y | 1.059 | 0.17 |
| 652_E | 727_P | 1.059 | 0.17 |
| 31_F | 916_H | 1.058 | 0.17 |
| 708_F | 715_A | 1.057 | 0.17 |
| 923_L | 929_S | 1.057 | 0.17 |
| 611_F | 703_H | 1.055 | 0.17 |
| 102_M | 130_H | 1.055 | 0.17 |
| 447_S | 760_V | 1.055 | 0.17 |
| 642_G | 931_A | 1.054 | 0.17 |
| 31_F | 178_I | 1.054 | 0.17 |
| 780_I | 824_F | 1.053 | 0.17 |
| 160_V | 466_L | 1.053 | 0.17 |
| 736_S | 793_I | 1.052 | 0.17 |
| 135_E | 286_L | 1.052 | 0.17 |
| 698_N | 900_L | 1.052 | 0.17 |
| 467_M | 793_I | 1.050 | 0.17 |
| 452_L | 700_K | 1.050 | 0.17 |
| 698_N | 719_A | 1.049 | 0.17 |
| 83_L | 713_H | 1.049 | 0.17 |
| 742_T | 848_Y | 1.049 | 0.17 |
| 97_T | 140_L | 1.047 | 0.16 |
| 87_P | 108_L | 1.047 | 0.16 |
| 852_V | 870_Y | 1.047 | 0.16 |
| 325_F | 345_T | 1.046 | 0.16 |
| 60_P | 182_L | 1.045 | 0.16 |
| 149_S | 154_F | 1.045 | 0.16 |
| 452_L | 977_H | 1.044 | 0.16 |
| 248_R | 253_G | 1.044 | 0.16 |
| 247_Q | 409_G | 1.044 | 0.16 |
| 129_L | 309_F | 1.044 | 0.16 |
| 69_G | 517_G | 1.043 | 0.16 |
| 709_L | 803_V | 1.043 | 0.16 |
| 454_Q | 882_I | 1.043 | 0.16 |
| 261_G | 266_C | 1.042 | 0.16 |
| 590_P | 831_A | 1.042 | 0.16 |
| 263_S | 266_C | 1.042 | 0.16 |
| 842_V | 969_L | 1.042 | 0.16 |
| 519_G | 718_R | 1.041 | 0.16 |
| 914_F | 917_F | 1.041 | 0.16 |
| 20_G | 203_L | 1.041 | 0.16 |
| 474_P | 513_L | 1.041 | 0.16 |
| 174_S | 286_L | 1.041 | 0.16 |
| 21_R | 437_L | 1.041 | 0.16 |
| 101_H | 348_E | 1.041 | 0.16 |
| 180_D | 623_S | 1.040 | 0.16 |
| 98_V | 108_L | 1.040 | 0.16 |
| 744_E | 822_G | 1.040 | 0.16 |
| 289_V | 924_I | 1.040 | 0.16 |
| 202_D | 339_S | 1.040 | 0.16 |
| 193_M | 221_T | 1.039 | 0.16 |
| 258_S | 514_N | 1.038 | 0.16 |
| 88_Q | 163_L | 1.038 | 0.16 |
| 787_S | 840_A | 1.038 | 0.16 |
| 37_T | 45_A | 1.037 | 0.16 |
| 75_S | 290_V | 1.037 | 0.16 |
| 249_K | 253_G | 1.037 | 0.16 |
| 38_A | 976_R | 1.036 | 0.16 |
| 468_L | 494_F | 1.035 | 0.16 |
| 251_S | 265_T | 1.035 | 0.16 |
| 771_V | 830_K | 1.035 | 0.16 |
| 14_K | 45_A | 1.035 | 0.16 |
| 822_G | 963_E | 1.035 | 0.16 |
| 253_G | 261_G | 1.033 | 0.16 |
| 252_E | 255_C | 1.033 | 0.16 |
| 36_I | 40_L | 1.032 | 0.16 |
| 36_I | 44_G | 1.032 | 0.16 |
| 23_A | 55_T | 1.032 | 0.16 |
| 99_A | 158_A | 1.032 | 0.16 |
| 933_T | 944_S | 1.030 | 0.16 |
| 55_T | 796_V | 1.030 | 0.16 |
| 309_F | 720_S | 1.029 | 0.16 |
| 251_S | 254_T | 1.029 | 0.16 |
| 23_A | 50_T | 1.029 | 0.16 |
| 194_S | 760_V | 1.029 | 0.16 |
| 638_I | 707_S | 1.029 | 0.16 |
| 542_P | 557_W | 1.029 | 0.16 |
| 791_Q | 802_W | 1.029 | 0.16 |
| 271_D | 274_T | 1.028 | 0.16 |
| 657_F | 675_E | 1.028 | 0.16 |
| 253_G | 263_S | 1.028 | 0.16 |
| 177_S | 880_I | 1.027 | 0.16 |
| 332_L | 974_V | 1.027 | 0.16 |
| 101_H | 104_F | 1.027 | 0.16 |
| 612_L | 634_R | 1.027 | 0.16 |
| 856_M | 871_V | 1.027 | 0.16 |
| 157_D | 523_L | 1.026 | 0.16 |
| 766_F | 875_C | 1.026 | 0.16 |
| 310_L | 670_G | 1.026 | 0.16 |
| 251_S | 257_C | 1.025 | 0.16 |
| 951_D | 968_F | 1.025 | 0.16 |
| 15_I | 21_R | 1.024 | 0.16 |
| 708_F | 749_I | 1.024 | 0.16 |
| 880_I | 963_E | 1.023 | 0.16 |
| 151_A | 604_T | 1.023 | 0.16 |
| 264_T | 268_A | 1.023 | 0.16 |
| 49_T | 186_R | 1.023 | 0.16 |
| 714_N | 732_I | 1.022 | 0.16 |
| 919_L | 923_L | 1.021 | 0.16 |
| 289_V | 931_A | 1.021 | 0.16 |
| 37_T | 40_L | 1.021 | 0.16 |
| 37_T | 44_G | 1.021 | 0.16 |
| 45_A | 49_T | 1.021 | 0.16 |
| 780_I | 808_W | 1.020 | 0.16 |
| 69_G | 783_R | 1.020 | 0.16 |
| 342_I | 852_V | 1.020 | 0.16 |
| 868_T | 947_P | 1.020 | 0.16 |
| 232_G | 446_R | 1.020 | 0.16 |
| 65_V | 468_L | 1.020 | 0.16 |
| 337_L | 611_F | 1.020 | 0.16 |
| 146_R | 802_W | 1.019 | 0.16 |
| 233_L | 967_Y | 1.019 | 0.16 |
| 154_F | 854_P | 1.019 | 0.16 |
| 343_S | 954_G | 1.019 | 0.16 |
| 532_P | 811_M | 1.019 | 0.16 |
| 205_G | 859_A | 1.019 | 0.16 |
| 753_T | 946_N | 1.017 | 0.15 |
| 577_L | 708_F | 1.017 | 0.15 |
| 40_L | 88_Q | 1.017 | 0.15 |
| 44_G | 88_Q | 1.017 | 0.15 |
| 268_A | 273_L | 1.017 | 0.15 |
| 767_S | 873_L | 1.017 | 0.15 |
| 950_W | 976_R | 1.016 | 0.15 |
| 202_D | 449_K | 1.016 | 0.15 |
| 345_T | 349_E | 1.016 | 0.15 |
| 91_I | 219_S | 1.016 | 0.15 |
| 256_S | 273_L | 1.016 | 0.15 |
| 267_P | 280_D | 1.015 | 0.15 |
| 260_K | 274_T | 1.015 | 0.15 |
| 212_A | 497_M | 1.015 | 0.15 |
| 820_V | 870_Y | 1.014 | 0.15 |
| 927_A | 937_A | 1.014 | 0.15 |
| 205_G | 211_I | 1.014 | 0.15 |
| 104_F | 108_L | 1.014 | 0.15 |
| 437_L | 676_A | 1.013 | 0.15 |
| 173_Y | 339_S | 1.013 | 0.15 |
| 259_S | 276_E | 1.012 | 0.15 |
| 906_V | 948_F | 1.012 | 0.15 |
| 916_H | 960_M | 1.011 | 0.15 |
| 256_S | 260_K | 1.011 | 0.15 |
| 796_V | 894_F | 1.011 | 0.15 |
| 179_W | 802_W | 1.010 | 0.15 |
| 16_F | 158_A | 1.010 | 0.15 |
| 336_G | 447_S | 1.010 | 0.15 |
| 254_T | 260_K | 1.010 | 0.15 |
| 350_I | 914_F | 1.010 | 0.15 |
| 627_K | 630_V | 1.010 | 0.15 |
| 263_S | 268_A | 1.009 | 0.15 |
| 714_N | 738_P | 1.009 | 0.15 |
| 828_Q | 838_L | 1.009 | 0.15 |
| 392_P | 396_N | 1.008 | 0.15 |
| 45_A | 50_T | 1.008 | 0.15 |
| 160_V | 603_L | 1.008 | 0.15 |
| 661_L | 825_I | 1.008 | 0.15 |
| 304_G | 776_V | 1.008 | 0.15 |
| 35_Q | 59_P | 1.007 | 0.15 |
| 250_G | 261_G | 1.007 | 0.15 |
| 157_D | 520_N | 1.006 | 0.15 |
| 795_G | 801_Y | 1.006 | 0.15 |
| 229_F | 477_E | 1.006 | 0.15 |
| 785_N | 807_L | 1.006 | 0.15 |
| 350_I | 496_S | 1.005 | 0.15 |
| 194_S | 447_S | 1.004 | 0.15 |
| 65_V | 433_V | 1.003 | 0.15 |
| 263_S | 267_P | 1.003 | 0.15 |
| 332_L | 455_I | 1.003 | 0.15 |
| 877_N | 907_L | 1.003 | 0.15 |
| 64_T | 159_K | 1.002 | 0.15 |
| 424_T | 437_L | 1.002 | 0.15 |
| 790_L | 802_W | 1.001 | 0.15 |
| 24_V | 37_T | 1.001 | 0.15 |
| 813_Y | 849_G | 1.000 | 0.15 |
| 297_A | 309_F | 1.000 | 0.15 |
| 48_T | 52_S | 1.000 | 0.15 |
| 878_L | 975_Q | 1.000 | 0.15 |
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
- Text file of contact predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
- Import to GREMLIN BETA - features includes ability to upload PDB and latest P(contact) calculation based on eLife 2015 fitting to PDB data.
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | M | Cov | P(%) | HHΔ | |
| 4yerA | 2 | 0.2877 | 100 | 0.825 | Contact Map |
| 3tuiC | 4 | 0.3374 | 100 | 0.852 | Contact Map |
| 4rvcA | 1 | 0.2361 | 100 | 0.853 | Contact Map |
| 1vplA | 1 | 0.2361 | 100 | 0.853 | Contact Map |
| 4u00A | 1 | 0 | 100 | 0.857 | Contact Map |
| 4ymuJ | 2 | 0 | 100 | 0.858 | Contact Map |
| 2oljA | 2 | 0.2401 | 100 | 0.858 | Contact Map |
| 4mkiB | 2 | 0.2695 | 100 | 0.859 | Contact Map |
| 4huqB | 1 | 0.2725 | 100 | 0.859 | Contact Map |
| 1z47A | 2 | 0.3404 | 100 | 0.859 | Contact Map |
Cov = coverage of hit
P(%) = probability
Sequence Conservation (Image Generated using WebLogo v3)