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OPENSEQ.org

DRD2

ID: 1487092725 Query Sequence

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 443 (414)
Sequences: 689 (457.9)
Seq/Len: 1.664
Nf(neff/√len): 22.5

HHblits Results: (2016_02)
Sequences per length for each position, BEFORE the coverage/gap filter was applied

Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 1.664).

Sequences per length for each position, AFTER the coverage/gap filter was applied
Legend: If visible, the positions blocked in grey are regions that have > 75% gaps and were automatically trimmed and excluded in the GREMLIN analysis.

Trim query Generate MSA using: Filter MSA GREMLIN
Start: End: E-value: Iterations: Coverage: Remove gaps: Prior:

GREMLIN Results:
Residue pairs sorted by coevolution strength:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.

ij Scaled score Prob
70_N205_T2.0970.99
422_N426_Y2.0270.99
75_S368_E2.0190.99
59_V74_V1.8940.98
107_C182_C1.8400.97
160_W201_P1.8040.96
122_I390_F1.7920.96
122_I415_G1.7870.96
418_N422_N1.7500.96
75_S124_N1.7370.95
433_F437_F1.7350.95
48_I84_A1.7250.95
72_L393_H1.6960.94
142_Y418_N1.6920.94
390_F415_G1.6180.92
119_T122_I1.5610.91
422_N434_R1.5550.90
110_F372_T1.5190.89
75_S160_W1.5170.89
62_E439_K1.5090.89
80_D422_N1.4860.87
45_I92_V1.4850.87
382_F422_N1.4670.87
125_L205_T1.4620.86
422_N433_F1.4600.86
80_D132_R1.4270.84
205_T209_Y1.4020.83
169_P205_T1.4000.83
416_Y423_P1.4000.83
100_W142_Y1.3980.83
115_V122_I1.3970.83
100_W103_S1.3920.82
130_I134_T1.3920.82
126_C376_A1.3790.82
100_W201_P1.3770.81
426_Y433_F1.3750.81
209_Y416_Y1.3580.80
415_G425_I1.3550.80
115_V389_F1.3510.80
126_C389_F1.3480.80
164_F410_A1.3370.79
100_W121_S1.3250.78
92_V430_N1.3210.78
115_V429_F1.3170.77
119_T390_F1.3160.77
384_I404_P1.3150.77
416_Y419_S1.3130.77
389_F415_G1.3120.77
51_G129_S1.3030.76
418_N433_F1.3020.76
51_G77_A1.3010.76
54_L139_P1.2900.75
134_T139_P1.2850.75
46_A387_L1.2800.74
81_L379_L1.2790.74
116_M208_V1.2770.74
139_P192_Y1.2690.74
95_E409_S1.2660.73
416_Y430_N1.2620.73
73_I387_L1.2580.73
65_L413_W1.2550.72
213_Y375_L1.2510.72
137_A219_R1.2490.72
92_V370_K1.2440.71
114_D368_E1.2420.71
193_S380_G1.2390.71
413_W423_P1.2360.71
69_T135_A1.2350.71
114_D118_C1.2340.71
389_F425_I1.2290.70
84_A152_V1.2200.69
119_T415_G1.2200.69
77_A125_L1.2200.69
102_F213_Y1.2180.69
77_A128_I1.2180.69
190_V193_S1.2150.69
200_V398_H1.2100.68
160_W413_W1.2090.68
115_V415_G1.2070.68
87_V390_F1.2030.68
83_V385_C1.2030.68
68_T72_L1.2020.68
419_S422_N1.2020.68
87_V122_I1.1980.67
124_N367_K1.1940.67
208_V420_A1.1940.67
362_K384_I1.1940.67
73_I173_G1.1930.67
55_V77_A1.1930.67
75_S114_D1.1910.67
73_I143_N1.1910.67
62_E125_L1.1900.67
55_V198_F1.1860.66
415_G429_F1.1810.66
160_W423_P1.1770.65
124_N429_F1.1760.65
385_C436_A1.1750.65
79_A419_S1.1730.65
83_V390_F1.1720.65
193_S389_F1.1680.64
131_D418_N1.1640.64
145_R148_S1.1600.64
389_F429_F1.1580.63
370_K427_T1.1580.63
96_V211_K1.1500.63
416_Y427_T1.1470.62
114_D119_T1.1460.62
115_V390_F1.1430.62
208_V212_I1.1420.62
198_F386_W1.1410.62
56_C74_V1.1380.61
134_T145_R1.1340.61
70_N88_M1.1340.61
62_E436_A1.1320.61
87_V115_V1.1300.61
83_V415_G1.1300.61
59_V415_G1.1240.60
375_L434_R1.1230.60
395_L410_A1.1220.60
132_R388_P1.1220.60
151_R375_L1.1210.60
423_P426_Y1.1160.59
202_F383_I1.1140.59
67_T430_N1.1130.59
200_V369_K1.1130.59
115_V167_S1.1120.59
107_C386_W1.1090.58
418_N426_Y1.1080.58
79_A124_N1.1070.58
80_D418_N1.1070.58
75_S419_S1.1060.58
129_S370_K1.1060.58
166_I196_V1.1050.58
121_S142_Y1.1050.58
125_L169_P1.0990.57
118_C385_C1.0980.57
129_S220_R1.0910.57
385_C425_I1.0910.57
100_W160_W1.0860.56
69_T129_S1.0860.56
140_M172_F1.0840.56
86_L212_I1.0840.56
115_V425_I1.0830.56
69_T134_T1.0820.56
201_P413_W1.0810.56
33_H37_Y1.0800.55
212_I418_N1.0800.55
190_V393_H1.0790.55
64_A136_V1.0770.55
419_S423_P1.0770.55
359_S378_V1.0760.55
106_H202_F1.0750.55
83_V159_V1.0750.55
97_V161_V1.0740.55
96_V203_I1.0720.55
65_L70_N1.0700.54
218_R424_I1.0700.54
115_V119_T1.0670.54
71_Y373_Q1.0670.54
87_V119_T1.0660.54
364_S367_K1.0650.54
380_G432_E1.0640.54
52_N80_D1.0600.53
105_I136_V1.0580.53
120_A200_V1.0580.53
136_V394_I1.0560.53
197_S415_G1.0550.53
375_L433_F1.0550.53
51_G125_L1.0540.53
110_F114_D1.0530.53
190_V197_S1.0520.52
89_P436_A1.0510.52
418_N438_L1.0510.52
134_T138_M1.0500.52
118_C389_F1.0490.52
128_I419_S1.0450.52
75_S201_P1.0430.52
89_P116_M1.0400.51
63_K96_V1.0400.51
111_V412_T1.0390.51
102_F432_E1.0390.51
375_L386_W1.0390.51
84_A110_F1.0380.51
77_A129_S1.0340.51
190_V194_S1.0340.51
122_I198_F1.0330.50
114_D124_N1.0320.50
156_I377_I1.0280.50
47_V105_I1.0210.49
100_W419_S1.0210.49
70_N201_P1.0200.49
122_I389_F1.0200.49
119_T197_S1.0190.49
114_D386_W1.0190.49
64_A140_M1.0190.49
69_T139_P1.0190.49
393_H412_T1.0170.49
119_T385_C1.0170.49
370_K436_A1.0170.49
51_G107_C1.0160.49
182_C198_F1.0130.48
55_V386_W1.0120.48
320_D323_A1.0120.48
84_A428_T1.0120.48
114_D198_F1.0110.48
72_L152_V1.0110.48
72_L417_V1.0100.48
106_H130_I1.0090.48
76_L79_A1.0070.48
91_V122_I1.0070.48
66_Q432_E1.0060.48
139_P205_T1.0060.48
72_L141_L1.0060.48
37_Y172_F1.0040.47
121_S198_F1.0030.47
114_D199_Y1.0020.47
287_T291_E1.0020.47
69_T208_V1.0020.47
Legend: Only predictions with Scaled Score > 1 are listed. For all 3L/2 predictions, click on one of the links below.
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
NEW Features
HHsearch Results: (06Aug15)
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
PDB M Cov P(%) HHΔ  
3pblA20.90071000.425Contact Map
4iarA10.84881000.426Contact Map
2rh1A10.92781000.432Contact Map
3uonA10.9211000.445Contact Map
4pxzA10.83521000.448Contact Map
3rzeA10.90071000.454Contact Map
3emlA10.91651000.454Contact Map
3oduA20.92781000.457Contact Map
4grvA10.91871000.46Contact Map
3vw7A10.90071000.464Contact Map
M = number of chains, if homo-oligomer
Cov = coverage of hit
P(%) = probability

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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