| ABCB1 |
| ID: | 1463062188 |
Query Sequence |
Download Alignment We filter this alignment to remove positions that have > 75% gaps before running GREMLIN. |
| Length: | 925 (915) | ||
| Sequences: | 7988 (5550.3) | ||
| Seq/Len: | 8.730 | ||
| Nf(neff/√len): | 183.5 |
HHblits Results: (2016_02)
Sequences per length for each position, BEFORE the coverage/gap filter was applied
Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 8.730).
Sequences per length for each position, AFTER the coverage/gap filter was applied
Residue pairs sorted by coevolution strength:
Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.
| i | j | Scaled score | Prob |
| 900_G | 904_Q | 6.414 | 1.00 |
| 684_E | 700_G | 5.035 | 1.00 |
| 681_T | 704_E | 4.853 | 1.00 |
| 683_G | 738_K | 4.700 | 1.00 |
| 709_Q | 887_L | 4.655 | 1.00 |
| 706_K | 709_Q | 4.484 | 1.00 |
| 41_N | 57_G | 4.100 | 1.00 |
| 686_V | 700_G | 4.045 | 1.00 |
| 127_T | 131_E | 3.995 | 1.00 |
| 39_F | 42_V | 3.762 | 1.00 |
| 679_N | 704_E | 3.756 | 1.00 |
| 682_F | 685_V | 3.601 | 1.00 |
| 38_E | 61_K | 3.488 | 1.00 |
| 56_K | 250_V | 3.418 | 1.00 |
| 146_E | 158_I | 3.381 | 1.00 |
| 130_A | 166_D | 3.217 | 1.00 |
| 795_K | 800_H | 3.118 | 1.00 |
| 738_K | 745_E | 3.029 | 1.00 |
| 686_V | 696_P | 2.992 | 1.00 |
| 897_K | 911_I | 2.933 | 1.00 |
| 66_Q | 242_V | 2.920 | 1.00 |
| 80_T | 89_Y | 2.919 | 1.00 |
| 63_Q | 66_Q | 2.895 | 1.00 |
| 745_E | 748_R | 2.887 | 1.00 |
| 683_G | 740_L | 2.823 | 1.00 |
| 242_V | 254_K | 2.810 | 1.00 |
| 913_F | 917_S | 2.788 | 1.00 |
| 776_I | 790_I | 2.783 | 1.00 |
| 60_L | 244_A | 2.779 | 1.00 |
| 864_D | 884_N | 2.764 | 1.00 |
| 901_T | 904_Q | 2.757 | 1.00 |
| 493_I | 497_I | 2.756 | 1.00 |
| 147_K | 155_Y | 2.738 | 1.00 |
| 155_Y | 165_F | 2.735 | 1.00 |
| 703_L | 889_V | 2.653 | 1.00 |
| 119_S | 551_T | 2.651 | 1.00 |
| 874_V | 885_A | 2.646 | 1.00 |
| 62_V | 68_V | 2.610 | 1.00 |
| 682_F | 703_L | 2.589 | 1.00 |
| 786_S | 789_E | 2.577 | 1.00 |
| 564_M | 568_S | 2.560 | 1.00 |
| 699_Q | 895_R | 2.555 | 1.00 |
| 470_V | 653_I | 2.545 | 1.00 |
| 800_H | 810_Y | 2.544 | 1.00 |
| 861_E | 865_K | 2.470 | 1.00 |
| 773_A | 787_Q | 2.459 | 1.00 |
| 557_Q | 560_K | 2.454 | 1.00 |
| 700_G | 895_R | 2.440 | 1.00 |
| 889_V | 896_V | 2.425 | 1.00 |
| 889_V | 899_H | 2.404 | 1.00 |
| 399_L | 403_L | 2.386 | 1.00 |
| 741_L | 841_I | 2.360 | 1.00 |
| 70_L | 81_T | 2.351 | 1.00 |
| 902_H | 912_Y | 2.339 | 1.00 |
| 43_H | 57_G | 2.337 | 1.00 |
| 534_E | 537_G | 2.317 | 1.00 |
| 256_N | 259_E | 2.315 | 1.00 |
| 679_N | 706_K | 2.277 | 1.00 |
| 57_G | 250_V | 2.269 | 1.00 |
| 729_E | 843_L | 2.253 | 1.00 |
| 82_V | 198_L | 2.238 | 1.00 |
| 887_L | 899_H | 2.227 | 1.00 |
| 330_K | 335_E | 2.226 | 1.00 |
| 892_Q | 897_K | 2.220 | 1.00 |
| 678_G | 742_D | 2.211 | 1.00 |
| 772_I | 829_I | 2.185 | 1.00 |
| 582_I | 586_T | 2.185 | 1.00 |
| 82_V | 230_I | 2.153 | 1.00 |
| 680_V | 741_L | 2.128 | 1.00 |
| 814_V | 821_L | 2.114 | 1.00 |
| 206_L | 214_V | 2.114 | 1.00 |
| 713_L | 873_I | 2.114 | 1.00 |
| 750_N | 753_W | 2.112 | 1.00 |
| 684_E | 702_S | 2.103 | 1.00 |
| 791_V | 795_K | 2.085 | 1.00 |
| 40_R | 95_M | 2.061 | 1.00 |
| 654_I | 658_E | 2.053 | 1.00 |
| 876_A | 881_T | 2.047 | 1.00 |
| 679_N | 707_K | 2.038 | 1.00 |
| 193_N | 225_R | 2.028 | 1.00 |
| 773_A | 811_S | 2.023 | 1.00 |
| 150_K | 213_V | 2.019 | 1.00 |
| 190_L | 217_A | 2.014 | 1.00 |
| 685_V | 734_P | 2.004 | 1.00 |
| 725_V | 875_I | 2.000 | 1.00 |
| 891_F | 896_V | 1.989 | 1.00 |
| 729_E | 758_L | 1.974 | 1.00 |
| 792_R | 796_E | 1.961 | 1.00 |
| 129_I | 184_I | 1.958 | 1.00 |
| 145_I | 149_V | 1.945 | 1.00 |
| 680_V | 841_I | 1.938 | 1.00 |
| 41_N | 59_N | 1.937 | 1.00 |
| 133_I | 149_V | 1.928 | 1.00 |
| 687_F | 732_Y | 1.927 | 1.00 |
| 69_A | 240_A | 1.919 | 1.00 |
| 257_H | 267_Y | 1.908 | 1.00 |
| 705_V | 711_L | 1.900 | 1.00 |
| 680_V | 873_I | 1.897 | 1.00 |
| 681_T | 740_L | 1.894 | 1.00 |
| 725_V | 843_L | 1.891 | 1.00 |
| 796_E | 866_A | 1.888 | 1.00 |
| 898_E | 905_L | 1.863 | 1.00 |
| 88_L | 553_V | 1.854 | 1.00 |
| 84_L | 89_Y | 1.845 | 1.00 |
| 701_L | 896_V | 1.845 | 1.00 |
| 402_L | 406_A | 1.838 | 1.00 |
| 142_M | 165_F | 1.834 | 1.00 |
| 155_Y | 159_M | 1.832 | 1.00 |
| 170_G | 173_G | 1.832 | 1.00 |
| 912_Y | 915_M | 1.819 | 1.00 |
| 711_L | 889_V | 1.817 | 1.00 |
| 789_E | 838_Q | 1.808 | 1.00 |
| 713_L | 724_V | 1.803 | 1.00 |
| 856_E | 860_Q | 1.802 | 1.00 |
| 729_E | 760_I | 1.782 | 1.00 |
| 730_R | 733_D | 1.760 | 1.00 |
| 462_R | 466_D | 1.748 | 1.00 |
| 688_N | 735_L | 1.748 | 1.00 |
| 68_V | 242_V | 1.747 | 1.00 |
| 791_V | 800_H | 1.736 | 1.00 |
| 635_Q | 638_S | 1.734 | 1.00 |
| 625_A | 629_G | 1.733 | 1.00 |
| 146_E | 150_K | 1.732 | 1.00 |
| 911_I | 914_S | 1.726 | 1.00 |
| 790_I | 836_V | 1.715 | 1.00 |
| 186_I | 199_L | 1.710 | 1.00 |
| 690_P | 693_P | 1.702 | 1.00 |
| 444_Q | 659_K | 1.700 | 1.00 |
| 161_L | 167_T | 1.694 | 1.00 |
| 10_I | 14_I | 1.692 | 1.00 |
| 86_Q | 117_V | 1.687 | 1.00 |
| 706_K | 887_L | 1.685 | 1.00 |
| 122_P | 182_Q | 1.678 | 1.00 |
| 255_G | 259_E | 1.673 | 1.00 |
| 37_L | 228_I | 1.663 | 1.00 |
| 255_G | 260_L | 1.655 | 1.00 |
| 11_F | 15_D | 1.637 | 1.00 |
| 793_A | 797_A | 1.636 | 1.00 |
| 102_D | 105_T | 1.632 | 1.00 |
| 139_N | 143_D | 1.627 | 1.00 |
| 496_F | 503_T | 1.624 | 1.00 |
| 116_G | 194_P | 1.620 | 1.00 |
| 63_Q | 242_V | 1.608 | 1.00 |
| 55_L | 58_L | 1.597 | 1.00 |
| 79_S | 83_Q | 1.593 | 1.00 |
| 344_R | 658_E | 1.591 | 1.00 |
| 906_L | 916_V | 1.589 | 1.00 |
| 660_T | 663_I | 1.588 | 1.00 |
| 4_R | 8_Y | 1.582 | 1.00 |
| 43_H | 93_E | 1.576 | 1.00 |
| 739_V | 746_I | 1.575 | 1.00 |
| 148_A | 221_A | 1.566 | 1.00 |
| 441_M | 449_F | 1.565 | 1.00 |
| 753_W | 757_H | 1.562 | 1.00 |
| 686_V | 736_A | 1.561 | 1.00 |
| 332_A | 335_E | 1.551 | 1.00 |
| 144_E | 147_K | 1.542 | 1.00 |
| 149_V | 165_F | 1.540 | 1.00 |
| 773_A | 777_A | 1.537 | 1.00 |
| 62_V | 228_I | 1.534 | 1.00 |
| 684_E | 736_A | 1.527 | 1.00 |
| 182_Q | 204_S | 1.525 | 1.00 |
| 746_I | 754_L | 1.523 | 1.00 |
| 39_F | 85_M | 1.518 | 1.00 |
| 659_K | 662_L | 1.515 | 1.00 |
| 39_F | 60_L | 1.503 | 1.00 |
| 432_R | 436_M | 1.499 | 1.00 |
| 808_N | 812_T | 1.499 | 1.00 |
| 36_N | 61_K | 1.495 | 1.00 |
| 904_Q | 907_A | 1.493 | 1.00 |
| 68_V | 244_A | 1.492 | 1.00 |
| 142_M | 146_E | 1.491 | 1.00 |
| 776_I | 794_A | 1.489 | 1.00 |
| 243_I | 257_H | 1.486 | 1.00 |
| 892_Q | 911_I | 1.485 | 1.00 |
| 902_H | 905_L | 1.483 | 1.00 |
| 680_V | 705_V | 1.474 | 1.00 |
| 40_R | 97_S | 1.472 | 1.00 |
| 499_G | 614_M | 1.465 | 1.00 |
| 330_K | 337_I | 1.456 | 0.99 |
| 455_T | 458_A | 1.451 | 0.99 |
| 759_G | 839_P | 1.442 | 0.99 |
| 86_Q | 554_S | 1.437 | 0.99 |
| 664_D | 750_N | 1.435 | 0.99 |
| 192_R | 197_L | 1.432 | 0.99 |
| 719_C | 723_T | 1.422 | 0.99 |
| 687_F | 723_T | 1.422 | 0.99 |
| 838_Q | 870_R | 1.421 | 0.99 |
| 156_D | 159_M | 1.419 | 0.99 |
| 131_E | 166_D | 1.418 | 0.99 |
| 794_A | 803_I | 1.416 | 0.99 |
| 905_L | 912_Y | 1.414 | 0.99 |
| 116_G | 192_R | 1.413 | 0.99 |
| 744_K | 749_L | 1.408 | 0.99 |
| 711_L | 899_H | 1.407 | 0.99 |
| 169_V | 175_Q | 1.407 | 0.99 |
| 176_L | 184_I | 1.401 | 0.99 |
| 883_Q | 903_Q | 1.400 | 0.99 |
| 625_A | 628_F | 1.400 | 0.99 |
| 900_G | 905_L | 1.399 | 0.99 |
| 163_H | 167_T | 1.396 | 0.99 |
| 125_F | 132_N | 1.395 | 0.99 |
| 620_L | 623_F | 1.394 | 0.99 |
| 794_A | 810_Y | 1.392 | 0.99 |
| 130_A | 134_R | 1.392 | 0.99 |
| 335_E | 338_P | 1.389 | 0.99 |
| 66_Q | 241_D | 1.386 | 0.99 |
| 856_E | 864_D | 1.385 | 0.99 |
| 857_K | 861_E | 1.385 | 0.99 |
| 179_G | 183_R | 1.382 | 0.99 |
| 623_F | 626_V | 1.380 | 0.99 |
| 624_S | 627_V | 1.376 | 0.99 |
| 440_S | 661_P | 1.376 | 0.99 |
| 244_A | 254_K | 1.370 | 0.99 |
| 663_I | 733_D | 1.370 | 0.99 |
| 698_L | 701_L | 1.366 | 0.99 |
| 398_N | 402_L | 1.366 | 0.99 |
| 247_D | 252_V | 1.363 | 0.99 |
| 814_V | 818_G | 1.363 | 0.99 |
| 39_F | 44_F | 1.358 | 0.99 |
| 711_L | 887_L | 1.355 | 0.99 |
| 437_V | 653_I | 1.353 | 0.99 |
| 42_V | 84_L | 1.351 | 0.99 |
| 709_Q | 899_H | 1.349 | 0.99 |
| 792_R | 795_K | 1.347 | 0.99 |
| 715_G | 718_G | 1.344 | 0.99 |
| 466_D | 652_H | 1.344 | 0.99 |
| 253_E | 260_L | 1.341 | 0.99 |
| 889_V | 900_G | 1.338 | 0.99 |
| 821_L | 829_I | 1.337 | 0.99 |
| 337_I | 342_F | 1.330 | 0.99 |
| 39_F | 58_L | 1.329 | 0.99 |
| 703_L | 896_V | 1.324 | 0.99 |
| 802_F | 825_Q | 1.323 | 0.99 |
| 663_I | 750_N | 1.320 | 0.99 |
| 749_L | 754_L | 1.320 | 0.99 |
| 433_L | 470_V | 1.319 | 0.99 |
| 267_Y | 270_L | 1.310 | 0.99 |
| 824_G | 827_Q | 1.302 | 0.99 |
| 173_G | 177_S | 1.301 | 0.99 |
| 253_E | 263_E | 1.300 | 0.99 |
| 541_I | 545_A | 1.293 | 0.99 |
| 133_I | 145_I | 1.293 | 0.99 |
| 53_K | 56_K | 1.292 | 0.98 |
| 63_Q | 68_V | 1.291 | 0.98 |
| 626_V | 630_A | 1.290 | 0.98 |
| 701_L | 891_F | 1.290 | 0.98 |
| 36_N | 64_S | 1.289 | 0.98 |
| 734_P | 747_K | 1.289 | 0.98 |
| 563_H | 567_Q | 1.288 | 0.98 |
| 621_L | 625_A | 1.286 | 0.98 |
| 626_V | 629_G | 1.275 | 0.98 |
| 890_V | 898_E | 1.275 | 0.98 |
| 145_I | 148_A | 1.270 | 0.98 |
| 440_S | 657_I | 1.259 | 0.98 |
| 798_N | 858_V | 1.259 | 0.98 |
| 604_F | 608_L | 1.257 | 0.98 |
| 338_P | 341_S | 1.256 | 0.98 |
| 800_H | 804_E | 1.256 | 0.98 |
| 45_S | 92_T | 1.255 | 0.98 |
| 128_T | 131_E | 1.255 | 0.98 |
| 257_H | 261_M | 1.255 | 0.98 |
| 180_Q | 183_R | 1.250 | 0.98 |
| 898_E | 910_G | 1.249 | 0.98 |
| 40_R | 59_N | 1.249 | 0.98 |
| 620_L | 624_S | 1.246 | 0.98 |
| 727_L | 739_V | 1.245 | 0.98 |
| 151_E | 154_A | 1.243 | 0.98 |
| 583_F | 586_T | 1.243 | 0.98 |
| 903_Q | 907_A | 1.242 | 0.98 |
| 749_L | 753_W | 1.238 | 0.98 |
| 692_R | 695_I | 1.237 | 0.98 |
| 130_A | 165_F | 1.233 | 0.98 |
| 533_K | 536_E | 1.230 | 0.98 |
| 778_Y | 781_N | 1.229 | 0.98 |
| 177_S | 180_Q | 1.223 | 0.98 |
| 206_L | 213_V | 1.220 | 0.98 |
| 146_E | 155_Y | 1.218 | 0.98 |
| 909_K | 913_F | 1.218 | 0.98 |
| 624_S | 628_F | 1.214 | 0.98 |
| 679_N | 743_G | 1.208 | 0.97 |
| 90_D | 104_R | 1.206 | 0.97 |
| 620_L | 625_A | 1.205 | 0.97 |
| 726_Q | 732_Y | 1.204 | 0.97 |
| 905_L | 915_M | 1.204 | 0.97 |
| 256_N | 260_L | 1.203 | 0.97 |
| 210_S | 717_S | 1.199 | 0.97 |
| 195_K | 225_R | 1.193 | 0.97 |
| 564_M | 567_Q | 1.192 | 0.97 |
| 468_A | 472_G | 1.190 | 0.97 |
| 785_V | 789_E | 1.190 | 0.97 |
| 130_A | 142_M | 1.189 | 0.97 |
| 335_E | 340_V | 1.189 | 0.97 |
| 715_G | 720_G | 1.188 | 0.97 |
| 860_Q | 881_T | 1.187 | 0.97 |
| 688_N | 696_P | 1.186 | 0.97 |
| 818_G | 826_K | 1.185 | 0.97 |
| 687_F | 727_L | 1.184 | 0.97 |
| 257_H | 260_L | 1.183 | 0.97 |
| 245_G | 255_G | 1.180 | 0.97 |
| 129_I | 169_V | 1.176 | 0.97 |
| 382_G | 386_R | 1.175 | 0.97 |
| 822_S | 827_Q | 1.173 | 0.97 |
| 118_V | 182_Q | 1.172 | 0.97 |
| 771_S | 774_E | 1.172 | 0.97 |
| 559_Q | 563_H | 1.171 | 0.97 |
| 789_E | 836_V | 1.171 | 0.97 |
| 231_A | 236_T | 1.170 | 0.97 |
| 822_S | 825_Q | 1.167 | 0.97 |
| 211_E | 236_T | 1.166 | 0.97 |
| 118_V | 189_A | 1.164 | 0.97 |
| 129_I | 158_I | 1.164 | 0.97 |
| 801_A | 804_E | 1.161 | 0.96 |
| 541_I | 568_S | 1.159 | 0.96 |
| 402_L | 405_L | 1.159 | 0.96 |
| 851_L | 859_V | 1.159 | 0.96 |
| 337_I | 341_S | 1.155 | 0.96 |
| 158_I | 165_F | 1.155 | 0.96 |
| 860_Q | 878_R | 1.155 | 0.96 |
| 125_F | 561_F | 1.154 | 0.96 |
| 114_I | 195_K | 1.150 | 0.96 |
| 378_S | 381_I | 1.148 | 0.96 |
| 58_L | 251_I | 1.148 | 0.96 |
| 159_M | 164_K | 1.147 | 0.96 |
| 211_E | 215_Q | 1.147 | 0.96 |
| 446_V | 450_D | 1.144 | 0.96 |
| 141_T | 144_E | 1.140 | 0.96 |
| 584_G | 588_S | 1.140 | 0.96 |
| 246_F | 251_I | 1.138 | 0.96 |
| 615_S | 618_D | 1.136 | 0.96 |
| 406_A | 410_I | 1.131 | 0.96 |
| 634_G | 638_S | 1.126 | 0.96 |
| 212_A | 216_V | 1.123 | 0.96 |
| 710_T | 885_A | 1.120 | 0.95 |
| 39_F | 81_T | 1.119 | 0.95 |
| 42_V | 91_P | 1.118 | 0.95 |
| 149_V | 158_I | 1.118 | 0.95 |
| 592_A | 596_F | 1.117 | 0.95 |
| 777_A | 790_I | 1.117 | 0.95 |
| 70_L | 228_I | 1.114 | 0.95 |
| 581_H | 584_G | 1.113 | 0.95 |
| 847_A | 876_A | 1.112 | 0.95 |
| 95_M | 102_D | 1.112 | 0.95 |
| 882_I | 888_I | 1.108 | 0.95 |
| 268_F | 272_T | 1.106 | 0.95 |
| 681_T | 702_S | 1.105 | 0.95 |
| 144_E | 148_A | 1.105 | 0.95 |
| 773_A | 790_I | 1.104 | 0.95 |
| 203_T | 206_L | 1.102 | 0.95 |
| 793_A | 836_V | 1.100 | 0.95 |
| 789_E | 792_R | 1.099 | 0.95 |
| 44_F | 91_P | 1.099 | 0.95 |
| 128_T | 166_D | 1.096 | 0.95 |
| 551_T | 555_L | 1.094 | 0.95 |
| 149_V | 190_L | 1.093 | 0.95 |
| 591_Q | 595_Y | 1.093 | 0.95 |
| 335_E | 341_S | 1.093 | 0.95 |
| 383_V | 386_R | 1.090 | 0.94 |
| 696_P | 699_Q | 1.090 | 0.94 |
| 128_T | 168_L | 1.088 | 0.94 |
| 730_R | 751_V | 1.087 | 0.94 |
| 529_L | 644_A | 1.084 | 0.94 |
| 35_G | 38_E | 1.083 | 0.94 |
| 426_G | 475_G | 1.083 | 0.94 |
| 396_N | 399_L | 1.082 | 0.94 |
| 803_I | 806_L | 1.081 | 0.94 |
| 768_F | 775_N | 1.080 | 0.94 |
| 38_E | 97_S | 1.079 | 0.94 |
| 60_L | 251_I | 1.079 | 0.94 |
| 258_D | 262_K | 1.078 | 0.94 |
| 331_E | 334_D | 1.078 | 0.94 |
| 624_S | 630_A | 1.077 | 0.94 |
| 182_Q | 186_I | 1.076 | 0.94 |
| 683_G | 702_S | 1.074 | 0.94 |
| 890_V | 905_L | 1.073 | 0.94 |
| 41_N | 93_E | 1.072 | 0.94 |
| 342_F | 345_I | 1.072 | 0.94 |
| 715_G | 721_K | 1.071 | 0.94 |
| 197_L | 225_R | 1.070 | 0.94 |
| 603_R | 607_Y | 1.068 | 0.94 |
| 67_T | 218_L | 1.065 | 0.94 |
| 146_E | 149_V | 1.061 | 0.93 |
| 845_D | 848_T | 1.061 | 0.93 |
| 72_G | 77_G | 1.060 | 0.93 |
| 264_K | 268_F | 1.059 | 0.93 |
| 505_L | 604_F | 1.058 | 0.93 |
| 35_G | 99_D | 1.058 | 0.93 |
| 772_I | 803_I | 1.051 | 0.93 |
| 71_V | 245_G | 1.051 | 0.93 |
| 501_Q | 504_L | 1.050 | 0.93 |
| 856_E | 878_R | 1.049 | 0.93 |
| 65_G | 226_T | 1.045 | 0.93 |
| 60_L | 81_T | 1.044 | 0.93 |
| 681_T | 743_G | 1.043 | 0.93 |
| 441_M | 448_W | 1.042 | 0.93 |
| 803_I | 809_K | 1.042 | 0.93 |
| 690_P | 695_I | 1.042 | 0.93 |
| 142_M | 151_E | 1.040 | 0.93 |
| 581_H | 588_S | 1.034 | 0.92 |
| 259_E | 263_E | 1.034 | 0.92 |
| 211_E | 214_V | 1.033 | 0.92 |
| 469_Q | 649_S | 1.031 | 0.92 |
| 787_Q | 791_V | 1.028 | 0.92 |
| 586_T | 590_T | 1.026 | 0.92 |
| 740_L | 745_E | 1.026 | 0.92 |
| 796_E | 865_K | 1.025 | 0.92 |
| 216_V | 220_K | 1.025 | 0.92 |
| 718_G | 721_K | 1.025 | 0.92 |
| 62_V | 226_T | 1.023 | 0.92 |
| 701_L | 724_V | 1.023 | 0.92 |
| 368_G | 372_A | 1.023 | 0.92 |
| 898_E | 912_Y | 1.022 | 0.92 |
| 705_V | 873_I | 1.021 | 0.92 |
| 424_K | 428_I | 1.020 | 0.92 |
| 343_W | 347_K | 1.015 | 0.91 |
| 757_H | 840_H | 1.015 | 0.91 |
| 403_L | 406_A | 1.014 | 0.91 |
| 75_G | 78_K | 1.014 | 0.91 |
| 846_E | 877_H | 1.008 | 0.91 |
| 439_R | 443_R | 1.007 | 0.91 |
| 397_S | 401_S | 1.005 | 0.91 |
| 441_M | 463_L | 1.004 | 0.91 |
| 581_H | 585_I | 1.003 | 0.91 |
| 244_A | 251_I | 1.003 | 0.91 |
| 177_S | 183_R | 1.002 | 0.91 |
| 36_N | 63_Q | 1.002 | 0.91 |
| 379_K | 383_V | 1.002 | 0.91 |
| 72_G | 78_K | 1.001 | 0.91 |
| 788_E | 792_R | 1.001 | 0.91 |
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
- Text file of contact predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
- See coupling matrix (for protein design or mutagenesis)
- Import to GREMLIN BETA - features includes ability to upload PDB and latest P(contact) calculation based on eLife 2015 fitting to PDB data.
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | M | Cov | P(%) | HHΔ | |
| 4q9hA | 1 | 0.9297 | 100 | 0.221 | Contact Map |
| 4f4cA | 1 | 0.9405 | 100 | 0.221 | Contact Map |
| 4ry2A | 2 | 0 | 100 | 0.538 | Contact Map |
| 4a82A | 4 | 0.6216 | 100 | 0.541 | Contact Map |
| 3wmgA | 1 | 0.6249 | 100 | 0.551 | Contact Map |
| 4q4hB | 1 | 0.6303 | 100 | 0.555 | Contact Map |
| 3zdqA | 1 | 0.6141 | 100 | 0.561 | Contact Map |
| 3b60A | 4 | 0.6184 | 100 | 0.565 | Contact Map |
| 4q4hA | 1 | 0.6184 | 100 | 0.565 | Contact Map |
| 3b5xA | 2 | 0.6184 | 100 | 0.567 | Contact Map |
Cov = coverage of hit
P(%) = probability
Sequence Conservation (Image Generated using WebLogo v3)