| 387sequences-1e-10-iterations4-coverage90 -force run |
| ID: | 1441599851 |
Query Sequence |
Download Alignment We filter this alignment to remove positions that have > 75% gaps before running GREMLIN. |
| Length: | 974 (973) | ||
| Sequences: | 106 (48.5) | ||
| Seq/Len: | 0.109 | ||
| Nf(neff/√len): | 1.6 |
HHblits Results: (2015_06)
Sequences per length for each position, BEFORE the coverage/gap filter was applied
Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 0.109).
Sequences per length for each position, AFTER the coverage/gap filter was applied
Residue pairs sorted by coevolution strength:
Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.
| i | j | Scaled score | Prob |
| 266_V | 458_C | 1.829 | 0.35 |
| 437_F | 517_C | 1.785 | 0.33 |
| 374_M | 455_Y | 1.713 | 0.30 |
| 74_H | 200_S | 1.701 | 0.29 |
| 482_K | 745_K | 1.680 | 0.28 |
| 644_I | 846_D | 1.657 | 0.27 |
| 186_I | 482_K | 1.652 | 0.27 |
| 60_Y | 482_K | 1.619 | 0.26 |
| 274_F | 739_R | 1.610 | 0.26 |
| 249_D | 353_V | 1.609 | 0.25 |
| 345_P | 682_D | 1.557 | 0.24 |
| 844_P | 956_P | 1.537 | 0.23 |
| 78_Y | 257_K | 1.528 | 0.22 |
| 749_H | 876_A | 1.527 | 0.22 |
| 517_C | 520_N | 1.503 | 0.22 |
| 468_Q | 479_Y | 1.500 | 0.21 |
| 433_S | 853_K | 1.499 | 0.21 |
| 130_I | 221_A | 1.485 | 0.21 |
| 256_K | 750_D | 1.465 | 0.20 |
| 46_H | 78_Y | 1.464 | 0.20 |
| 390_N | 786_H | 1.461 | 0.20 |
| 421_L | 750_D | 1.456 | 0.20 |
| 274_F | 544_I | 1.455 | 0.20 |
| 424_V | 625_L | 1.451 | 0.20 |
| 512_I | 824_I | 1.429 | 0.19 |
| 682_D | 828_N | 1.427 | 0.19 |
| 134_G | 350_N | 1.421 | 0.19 |
| 83_Y | 511_L | 1.419 | 0.19 |
| 387_L | 824_I | 1.418 | 0.19 |
| 274_F | 424_V | 1.410 | 0.19 |
| 89_C | 328_V | 1.408 | 0.18 |
| 209_S | 580_S | 1.404 | 0.18 |
| 353_V | 452_V | 1.398 | 0.18 |
| 402_F | 857_E | 1.398 | 0.18 |
| 107_P | 556_E | 1.395 | 0.18 |
| 76_V | 927_N | 1.395 | 0.18 |
| 80_I | 117_P | 1.394 | 0.18 |
| 225_L | 397_T | 1.394 | 0.18 |
| 78_Y | 452_V | 1.393 | 0.18 |
| 7_L | 355_R | 1.392 | 0.18 |
| 117_P | 173_A | 1.386 | 0.18 |
| 274_F | 327_T | 1.379 | 0.18 |
| 437_F | 464_N | 1.375 | 0.17 |
| 430_R | 547_T | 1.374 | 0.17 |
| 250_F | 279_L | 1.366 | 0.17 |
| 86_R | 281_F | 1.365 | 0.17 |
| 426_D | 848_E | 1.361 | 0.17 |
| 292_K | 544_I | 1.360 | 0.17 |
| 458_C | 583_T | 1.357 | 0.17 |
| 192_K | 941_Y | 1.354 | 0.17 |
| 134_G | 796_L | 1.347 | 0.17 |
| 274_F | 426_D | 1.344 | 0.17 |
| 42_T | 196_I | 1.342 | 0.17 |
| 256_K | 279_L | 1.342 | 0.17 |
| 572_L | 684_T | 1.340 | 0.16 |
| 100_I | 275_N | 1.338 | 0.16 |
| 437_F | 583_T | 1.337 | 0.16 |
| 31_I | 952_V | 1.336 | 0.16 |
| 902_E | 905_R | 1.336 | 0.16 |
| 78_Y | 219_A | 1.333 | 0.16 |
| 275_N | 344_K | 1.330 | 0.16 |
| 706_E | 709_R | 1.327 | 0.16 |
| 306_L | 496_A | 1.326 | 0.16 |
| 821_T | 893_I | 1.323 | 0.16 |
| 464_N | 517_C | 1.323 | 0.16 |
| 8_Y | 385_E | 1.309 | 0.16 |
| 643_I | 879_V | 1.308 | 0.16 |
| 268_R | 827_E | 1.307 | 0.16 |
| 520_N | 778_S | 1.306 | 0.16 |
| 589_C | 815_I | 1.306 | 0.16 |
| 33_I | 315_S | 1.303 | 0.15 |
| 31_I | 221_A | 1.302 | 0.15 |
| 739_R | 795_L | 1.297 | 0.15 |
| 927_N | 968_I | 1.292 | 0.15 |
| 444_S | 451_L | 1.289 | 0.15 |
| 130_I | 657_L | 1.285 | 0.15 |
| 417_E | 781_D | 1.280 | 0.15 |
| 68_I | 265_Y | 1.279 | 0.15 |
| 330_S | 337_F | 1.279 | 0.15 |
| 242_C | 706_E | 1.278 | 0.15 |
| 86_R | 562_P | 1.277 | 0.15 |
| 813_R | 874_S | 1.274 | 0.15 |
| 267_L | 316_L | 1.273 | 0.15 |
| 827_E | 891_T | 1.271 | 0.15 |
| 6_Y | 375_N | 1.270 | 0.15 |
| 76_V | 552_D | 1.269 | 0.15 |
| 63_N | 585_L | 1.269 | 0.15 |
| 580_S | 785_K | 1.268 | 0.15 |
| 403_K | 566_I | 1.266 | 0.14 |
| 692_K | 790_I | 1.266 | 0.14 |
| 437_F | 544_I | 1.265 | 0.14 |
| 555_Q | 829_E | 1.264 | 0.14 |
| 225_L | 589_C | 1.264 | 0.14 |
| 15_E | 211_I | 1.261 | 0.14 |
| 186_I | 742_E | 1.261 | 0.14 |
| 168_V | 265_Y | 1.258 | 0.14 |
| 3_L | 625_L | 1.255 | 0.14 |
| 840_T | 963_L | 1.255 | 0.14 |
| 401_I | 906_M | 1.253 | 0.14 |
| 180_E | 228_E | 1.253 | 0.14 |
| 425_L | 778_S | 1.251 | 0.14 |
| 480_L | 956_P | 1.251 | 0.14 |
| 565_C | 898_S | 1.247 | 0.14 |
| 575_A | 589_C | 1.245 | 0.14 |
| 63_N | 759_C | 1.245 | 0.14 |
| 327_T | 424_V | 1.244 | 0.14 |
| 159_Y | 527_E | 1.241 | 0.14 |
| 238_I | 596_L | 1.241 | 0.14 |
| 45_Y | 860_I | 1.239 | 0.14 |
| 453_L | 708_C | 1.239 | 0.14 |
| 114_V | 250_F | 1.239 | 0.14 |
| 642_A | 798_Y | 1.236 | 0.14 |
| 50_A | 118_G | 1.236 | 0.14 |
| 480_L | 844_P | 1.235 | 0.14 |
| 189_Q | 585_L | 1.231 | 0.14 |
| 437_F | 520_N | 1.230 | 0.14 |
| 400_K | 482_K | 1.227 | 0.14 |
| 516_V | 576_T | 1.225 | 0.13 |
| 451_L | 480_L | 1.223 | 0.13 |
| 347_D | 465_I | 1.223 | 0.13 |
| 251_A | 433_S | 1.223 | 0.13 |
| 335_F | 463_E | 1.222 | 0.13 |
| 78_Y | 237_N | 1.221 | 0.13 |
| 146_K | 533_N | 1.221 | 0.13 |
| 516_V | 903_F | 1.221 | 0.13 |
| 586_W | 630_M | 1.220 | 0.13 |
| 207_F | 826_V | 1.220 | 0.13 |
| 410_G | 968_I | 1.218 | 0.13 |
| 234_V | 601_S | 1.218 | 0.13 |
| 493_L | 701_N | 1.217 | 0.13 |
| 76_V | 321_N | 1.217 | 0.13 |
| 517_C | 870_E | 1.215 | 0.13 |
| 277_Y | 826_V | 1.212 | 0.13 |
| 470_F | 720_V | 1.208 | 0.13 |
| 601_S | 840_T | 1.207 | 0.13 |
| 35_A | 203_E | 1.203 | 0.13 |
| 683_P | 891_T | 1.203 | 0.13 |
| 813_R | 956_P | 1.202 | 0.13 |
| 228_E | 566_I | 1.201 | 0.13 |
| 147_E | 894_E | 1.194 | 0.13 |
| 221_A | 352_L | 1.194 | 0.13 |
| 265_Y | 567_E | 1.193 | 0.13 |
| 617_P | 914_Q | 1.189 | 0.13 |
| 8_Y | 625_L | 1.188 | 0.13 |
| 267_L | 342_P | 1.188 | 0.13 |
| 60_Y | 298_K | 1.187 | 0.13 |
| 91_G | 786_H | 1.186 | 0.13 |
| 617_P | 891_T | 1.186 | 0.13 |
| 426_D | 963_L | 1.183 | 0.12 |
| 565_C | 640_F | 1.183 | 0.12 |
| 112_F | 580_S | 1.182 | 0.12 |
| 264_L | 781_D | 1.180 | 0.12 |
| 64_H | 542_P | 1.180 | 0.12 |
| 640_F | 868_L | 1.179 | 0.12 |
| 617_P | 827_E | 1.178 | 0.12 |
| 39_C | 342_P | 1.178 | 0.12 |
| 240_S | 580_S | 1.177 | 0.12 |
| 387_L | 435_S | 1.177 | 0.12 |
| 205_L | 211_I | 1.175 | 0.12 |
| 452_V | 906_M | 1.173 | 0.12 |
| 50_A | 422_L | 1.173 | 0.12 |
| 664_L | 669_I | 1.173 | 0.12 |
| 246_I | 291_Y | 1.170 | 0.12 |
| 178_S | 673_G | 1.170 | 0.12 |
| 643_I | 773_Y | 1.168 | 0.12 |
| 318_D | 466_L | 1.168 | 0.12 |
| 304_Y | 571_N | 1.168 | 0.12 |
| 83_Y | 225_L | 1.167 | 0.12 |
| 160_C | 532_G | 1.164 | 0.12 |
| 78_Y | 810_G | 1.163 | 0.12 |
| 458_C | 927_N | 1.162 | 0.12 |
| 463_E | 743_I | 1.159 | 0.12 |
| 454_N | 798_Y | 1.159 | 0.12 |
| 586_W | 708_C | 1.158 | 0.12 |
| 221_A | 835_G | 1.156 | 0.12 |
| 102_R | 548_V | 1.156 | 0.12 |
| 60_Y | 186_I | 1.156 | 0.12 |
| 49_F | 190_D | 1.155 | 0.12 |
| 596_L | 625_L | 1.155 | 0.12 |
| 335_F | 516_V | 1.155 | 0.12 |
| 5_V | 923_L | 1.154 | 0.12 |
| 24_G | 112_F | 1.153 | 0.12 |
| 517_C | 778_S | 1.153 | 0.12 |
| 440_A | 743_I | 1.153 | 0.12 |
| 242_C | 586_W | 1.153 | 0.12 |
| 215_Y | 821_T | 1.153 | 0.12 |
| 242_C | 630_M | 1.151 | 0.12 |
| 50_A | 796_L | 1.150 | 0.12 |
| 31_I | 222_H | 1.150 | 0.12 |
| 93_N | 556_E | 1.150 | 0.12 |
| 756_K | 778_S | 1.150 | 0.12 |
| 743_I | 827_E | 1.150 | 0.12 |
| 475_S | 749_H | 1.150 | 0.12 |
| 765_R | 798_Y | 1.149 | 0.12 |
| 433_S | 590_S | 1.148 | 0.12 |
| 50_A | 402_F | 1.148 | 0.12 |
| 533_N | 829_E | 1.146 | 0.12 |
| 350_N | 796_L | 1.145 | 0.12 |
| 770_I | 824_I | 1.145 | 0.12 |
| 566_I | 794_K | 1.144 | 0.12 |
| 455_Y | 472_K | 1.144 | 0.12 |
| 537_I | 593_D | 1.144 | 0.12 |
| 392_S | 553_I | 1.144 | 0.12 |
| 699_K | 704_S | 1.144 | 0.12 |
| 480_L | 856_G | 1.143 | 0.12 |
| 60_Y | 317_K | 1.143 | 0.12 |
| 7_L | 554_L | 1.139 | 0.12 |
| 274_F | 729_S | 1.137 | 0.11 |
| 331_D | 646_D | 1.137 | 0.11 |
| 225_L | 751_N | 1.137 | 0.11 |
| 273_D | 683_P | 1.137 | 0.11 |
| 594_K | 812_K | 1.136 | 0.11 |
| 451_L | 956_P | 1.135 | 0.11 |
| 171_K | 646_D | 1.135 | 0.11 |
| 192_K | 452_V | 1.135 | 0.11 |
| 517_C | 544_I | 1.135 | 0.11 |
| 583_T | 756_K | 1.134 | 0.11 |
| 159_Y | 562_P | 1.134 | 0.11 |
| 165_I | 256_K | 1.132 | 0.11 |
| 249_D | 497_K | 1.132 | 0.11 |
| 575_A | 748_Q | 1.132 | 0.11 |
| 421_L | 905_R | 1.131 | 0.11 |
| 179_N | 973_A | 1.130 | 0.11 |
| 3_L | 706_E | 1.130 | 0.11 |
| 45_Y | 402_F | 1.129 | 0.11 |
| 200_S | 591_G | 1.127 | 0.11 |
| 452_V | 871_S | 1.127 | 0.11 |
| 856_G | 956_P | 1.127 | 0.11 |
| 202_R | 304_Y | 1.126 | 0.11 |
| 40_G | 279_L | 1.126 | 0.11 |
| 472_K | 566_I | 1.126 | 0.11 |
| 368_L | 566_I | 1.126 | 0.11 |
| 36_S | 140_W | 1.125 | 0.11 |
| 468_Q | 761_S | 1.125 | 0.11 |
| 268_R | 826_V | 1.125 | 0.11 |
| 267_L | 625_L | 1.124 | 0.11 |
| 281_F | 527_E | 1.124 | 0.11 |
| 453_L | 586_W | 1.124 | 0.11 |
| 640_F | 891_T | 1.124 | 0.11 |
| 615_P | 922_E | 1.124 | 0.11 |
| 194_L | 601_S | 1.122 | 0.11 |
| 355_R | 844_P | 1.122 | 0.11 |
| 650_L | 781_D | 1.122 | 0.11 |
| 810_G | 902_E | 1.122 | 0.11 |
| 418_T | 505_F | 1.120 | 0.11 |
| 211_I | 339_K | 1.120 | 0.11 |
| 275_N | 304_Y | 1.119 | 0.11 |
| 291_Y | 523_L | 1.115 | 0.11 |
| 316_L | 342_P | 1.115 | 0.11 |
| 422_L | 707_M | 1.115 | 0.11 |
| 451_L | 844_P | 1.115 | 0.11 |
| 114_V | 647_L | 1.115 | 0.11 |
| 583_T | 730_T | 1.113 | 0.11 |
| 566_I | 943_I | 1.113 | 0.11 |
| 421_L | 505_F | 1.112 | 0.11 |
| 494_E | 733_H | 1.112 | 0.11 |
| 353_V | 548_V | 1.111 | 0.11 |
| 355_R | 480_L | 1.111 | 0.11 |
| 18_Y | 42_T | 1.110 | 0.11 |
| 831_R | 851_K | 1.110 | 0.11 |
| 737_F | 798_Y | 1.110 | 0.11 |
| 188_K | 221_A | 1.108 | 0.11 |
| 493_L | 657_L | 1.108 | 0.11 |
| 625_L | 643_I | 1.107 | 0.11 |
| 856_G | 870_E | 1.107 | 0.11 |
| 130_I | 215_Y | 1.107 | 0.11 |
| 268_R | 437_F | 1.107 | 0.11 |
| 24_G | 203_E | 1.107 | 0.11 |
| 19_L | 848_E | 1.106 | 0.11 |
| 373_H | 470_F | 1.106 | 0.11 |
| 421_L | 749_H | 1.105 | 0.11 |
| 379_F | 863_Y | 1.105 | 0.11 |
| 208_V | 908_G | 1.105 | 0.11 |
| 516_V | 741_I | 1.103 | 0.11 |
| 489_I | 556_E | 1.103 | 0.11 |
| 159_Y | 281_F | 1.103 | 0.11 |
| 796_L | 892_Y | 1.102 | 0.11 |
| 345_P | 904_M | 1.102 | 0.11 |
| 82_F | 484_K | 1.102 | 0.11 |
| 187_H | 290_E | 1.101 | 0.11 |
| 441_S | 623_A | 1.098 | 0.11 |
| 31_I | 907_I | 1.097 | 0.11 |
| 640_F | 898_S | 1.097 | 0.11 |
| 264_L | 922_E | 1.097 | 0.11 |
| 355_R | 956_P | 1.096 | 0.11 |
| 5_V | 76_V | 1.095 | 0.11 |
| 165_I | 422_L | 1.095 | 0.11 |
| 96_Y | 209_S | 1.093 | 0.11 |
| 480_L | 639_S | 1.093 | 0.11 |
| 86_R | 524_I | 1.092 | 0.11 |
| 521_I | 898_S | 1.092 | 0.11 |
| 274_F | 963_L | 1.092 | 0.11 |
| 813_R | 844_P | 1.091 | 0.11 |
| 349_S | 565_C | 1.091 | 0.11 |
| 182_R | 435_S | 1.091 | 0.11 |
| 251_A | 648_N | 1.089 | 0.11 |
| 640_F | 827_E | 1.089 | 0.11 |
| 555_Q | 567_E | 1.088 | 0.11 |
| 165_I | 707_M | 1.088 | 0.11 |
| 249_D | 871_S | 1.088 | 0.11 |
| 397_T | 589_C | 1.087 | 0.10 |
| 643_I | 754_K | 1.086 | 0.10 |
| 515_N | 956_P | 1.086 | 0.10 |
| 292_K | 741_I | 1.084 | 0.10 |
| 264_L | 940_I | 1.083 | 0.10 |
| 807_E | 851_K | 1.083 | 0.10 |
| 586_W | 706_E | 1.083 | 0.10 |
| 186_I | 335_F | 1.082 | 0.10 |
| 482_K | 943_I | 1.082 | 0.10 |
| 704_S | 867_S | 1.082 | 0.10 |
| 30_E | 534_P | 1.082 | 0.10 |
| 254_K | 304_Y | 1.081 | 0.10 |
| 780_R | 900_P | 1.081 | 0.10 |
| 107_P | 601_S | 1.081 | 0.10 |
| 311_K | 692_K | 1.081 | 0.10 |
| 37_K | 739_R | 1.079 | 0.10 |
| 299_N | 661_N | 1.079 | 0.10 |
| 24_G | 518_A | 1.079 | 0.10 |
| 566_I | 624_N | 1.079 | 0.10 |
| 8_Y | 596_L | 1.079 | 0.10 |
| 225_L | 511_L | 1.078 | 0.10 |
| 54_E | 331_D | 1.077 | 0.10 |
| 78_Y | 163_P | 1.077 | 0.10 |
| 320_L | 739_R | 1.077 | 0.10 |
| 544_I | 871_S | 1.077 | 0.10 |
| 348_K | 874_S | 1.076 | 0.10 |
| 271_P | 493_L | 1.076 | 0.10 |
| 180_E | 657_L | 1.076 | 0.10 |
| 556_E | 748_Q | 1.076 | 0.10 |
| 379_F | 623_A | 1.076 | 0.10 |
| 209_S | 639_S | 1.074 | 0.10 |
| 251_A | 453_L | 1.074 | 0.10 |
| 782_Y | 814_Y | 1.074 | 0.10 |
| 76_V | 252_I | 1.074 | 0.10 |
| 215_Y | 728_H | 1.074 | 0.10 |
| 444_S | 780_R | 1.074 | 0.10 |
| 508_E | 810_G | 1.074 | 0.10 |
| 844_P | 856_G | 1.073 | 0.10 |
| 484_K | 781_D | 1.072 | 0.10 |
| 265_Y | 684_T | 1.072 | 0.10 |
| 601_S | 946_E | 1.072 | 0.10 |
| 44_V | 295_L | 1.071 | 0.10 |
| 280_T | 345_P | 1.071 | 0.10 |
| 565_C | 868_L | 1.071 | 0.10 |
| 278_F | 517_C | 1.071 | 0.10 |
| 756_K | 857_E | 1.071 | 0.10 |
| 668_R | 784_Q | 1.069 | 0.10 |
| 441_S | 622_L | 1.068 | 0.10 |
| 8_Y | 630_M | 1.067 | 0.10 |
| 845_Q | 893_I | 1.067 | 0.10 |
| 709_R | 847_K | 1.067 | 0.10 |
| 387_L | 431_N | 1.065 | 0.10 |
| 391_E | 804_K | 1.065 | 0.10 |
| 189_Q | 756_K | 1.065 | 0.10 |
| 259_G | 687_E | 1.064 | 0.10 |
| 287_N | 766_N | 1.064 | 0.10 |
| 758_V | 846_D | 1.064 | 0.10 |
| 778_S | 857_E | 1.064 | 0.10 |
| 4_Q | 252_I | 1.063 | 0.10 |
| 279_L | 626_I | 1.063 | 0.10 |
| 88_Y | 475_S | 1.063 | 0.10 |
| 215_Y | 597_S | 1.063 | 0.10 |
| 387_L | 916_I | 1.063 | 0.10 |
| 505_F | 580_S | 1.063 | 0.10 |
| 117_P | 910_D | 1.063 | 0.10 |
| 323_Y | 479_Y | 1.062 | 0.10 |
| 159_Y | 694_L | 1.062 | 0.10 |
| 515_N | 844_P | 1.062 | 0.10 |
| 743_I | 891_T | 1.059 | 0.10 |
| 70_E | 265_Y | 1.059 | 0.10 |
| 164_N | 748_Q | 1.058 | 0.10 |
| 7_L | 40_G | 1.058 | 0.10 |
| 251_A | 333_I | 1.058 | 0.10 |
| 317_K | 756_K | 1.058 | 0.10 |
| 324_Q | 745_K | 1.058 | 0.10 |
| 191_G | 521_I | 1.058 | 0.10 |
| 835_G | 876_A | 1.058 | 0.10 |
| 349_S | 745_K | 1.057 | 0.10 |
| 424_V | 812_K | 1.057 | 0.10 |
| 225_L | 749_H | 1.057 | 0.10 |
| 520_N | 872_K | 1.057 | 0.10 |
| 251_A | 280_T | 1.057 | 0.10 |
| 922_E | 953_N | 1.055 | 0.10 |
| 82_F | 422_L | 1.055 | 0.10 |
| 269_C | 756_K | 1.055 | 0.10 |
| 274_F | 736_D | 1.055 | 0.10 |
| 273_D | 568_N | 1.054 | 0.10 |
| 279_L | 856_G | 1.054 | 0.10 |
| 620_A | 824_I | 1.054 | 0.10 |
| 49_F | 168_V | 1.054 | 0.10 |
| 27_V | 475_S | 1.054 | 0.10 |
| 347_D | 552_D | 1.053 | 0.10 |
| 238_I | 510_T | 1.053 | 0.10 |
| 457_V | 461_G | 1.052 | 0.10 |
| 451_L | 487_I | 1.052 | 0.10 |
| 648_N | 656_E | 1.050 | 0.10 |
| 425_L | 520_N | 1.050 | 0.10 |
| 330_S | 921_I | 1.049 | 0.10 |
| 37_K | 73_R | 1.048 | 0.10 |
| 392_S | 761_S | 1.048 | 0.10 |
| 350_N | 422_L | 1.048 | 0.10 |
| 854_E | 923_L | 1.048 | 0.10 |
| 781_D | 940_I | 1.048 | 0.10 |
| 278_F | 455_Y | 1.046 | 0.10 |
| 387_L | 855_P | 1.046 | 0.10 |
| 273_D | 521_I | 1.046 | 0.10 |
| 482_K | 589_C | 1.046 | 0.10 |
| 616_A | 767_L | 1.045 | 0.10 |
| 379_F | 622_L | 1.045 | 0.10 |
| 320_L | 795_L | 1.044 | 0.10 |
| 402_F | 840_T | 1.044 | 0.10 |
| 379_F | 441_S | 1.044 | 0.10 |
| 505_F | 551_K | 1.044 | 0.10 |
| 693_F | 815_I | 1.044 | 0.10 |
| 21_F | 437_F | 1.043 | 0.10 |
| 240_S | 386_D | 1.043 | 0.10 |
| 211_I | 894_E | 1.043 | 0.10 |
| 313_F | 515_N | 1.041 | 0.10 |
| 268_R | 623_A | 1.041 | 0.10 |
| 440_A | 908_G | 1.040 | 0.10 |
| 454_N | 900_P | 1.040 | 0.10 |
| 444_S | 480_L | 1.040 | 0.10 |
| 194_L | 234_V | 1.040 | 0.10 |
| 23_S | 228_E | 1.040 | 0.10 |
| 313_F | 426_D | 1.040 | 0.10 |
| 335_F | 517_C | 1.040 | 0.10 |
| 804_K | 807_E | 1.039 | 0.10 |
| 79_R | 941_Y | 1.039 | 0.10 |
| 133_T | 253_S | 1.039 | 0.10 |
| 163_P | 774_L | 1.039 | 0.10 |
| 281_F | 707_M | 1.039 | 0.10 |
| 68_I | 353_V | 1.038 | 0.10 |
| 686_F | 873_F | 1.038 | 0.10 |
| 130_I | 728_H | 1.038 | 0.10 |
| 868_L | 891_T | 1.038 | 0.10 |
| 422_L | 682_D | 1.038 | 0.10 |
| 426_D | 515_N | 1.038 | 0.10 |
| 853_K | 907_I | 1.036 | 0.10 |
| 203_E | 786_H | 1.036 | 0.10 |
| 853_K | 943_I | 1.036 | 0.10 |
| 108_L | 932_R | 1.036 | 0.10 |
| 517_C | 814_Y | 1.035 | 0.10 |
| 265_Y | 590_S | 1.035 | 0.10 |
| 349_S | 640_F | 1.034 | 0.10 |
| 475_S | 860_I | 1.034 | 0.10 |
| 78_Y | 605_L | 1.033 | 0.09 |
| 265_Y | 555_Q | 1.033 | 0.09 |
| 79_R | 345_P | 1.033 | 0.09 |
| 630_M | 706_E | 1.033 | 0.09 |
| 291_Y | 519_K | 1.033 | 0.09 |
| 154_Q | 804_K | 1.031 | 0.09 |
| 130_I | 738_E | 1.031 | 0.09 |
| 274_F | 807_E | 1.030 | 0.09 |
| 299_N | 664_L | 1.030 | 0.09 |
| 72_T | 192_K | 1.029 | 0.09 |
| 357_N | 455_Y | 1.029 | 0.09 |
| 256_K | 332_N | 1.029 | 0.09 |
| 304_Y | 741_I | 1.029 | 0.09 |
| 54_E | 265_Y | 1.029 | 0.09 |
| 565_C | 891_T | 1.029 | 0.09 |
| 69_D | 373_H | 1.029 | 0.09 |
| 44_V | 770_I | 1.029 | 0.09 |
| 602_Q | 815_I | 1.028 | 0.09 |
| 625_L | 812_K | 1.028 | 0.09 |
| 589_C | 651_F | 1.028 | 0.09 |
| 480_L | 487_I | 1.028 | 0.09 |
| 556_E | 592_G | 1.026 | 0.09 |
| 433_S | 642_A | 1.026 | 0.09 |
| 107_P | 840_T | 1.026 | 0.09 |
| 46_H | 163_P | 1.026 | 0.09 |
| 364_T | 756_K | 1.024 | 0.09 |
| 215_Y | 893_I | 1.022 | 0.09 |
| 18_Y | 102_R | 1.022 | 0.09 |
| 208_V | 388_I | 1.022 | 0.09 |
| 781_D | 827_E | 1.022 | 0.09 |
| 69_D | 960_D | 1.021 | 0.09 |
| 60_Y | 963_L | 1.021 | 0.09 |
| 406_R | 699_K | 1.021 | 0.09 |
| 266_V | 568_N | 1.021 | 0.09 |
| 392_S | 552_D | 1.021 | 0.09 |
| 437_F | 870_E | 1.021 | 0.09 |
| 497_K | 650_L | 1.020 | 0.09 |
| 251_A | 708_C | 1.020 | 0.09 |
| 669_I | 672_L | 1.019 | 0.09 |
| 205_L | 596_L | 1.019 | 0.09 |
| 242_C | 709_R | 1.019 | 0.09 |
| 251_A | 642_A | 1.017 | 0.09 |
| 323_Y | 528_D | 1.016 | 0.09 |
| 475_S | 876_A | 1.016 | 0.09 |
| 455_Y | 505_F | 1.016 | 0.09 |
| 10_S | 164_N | 1.015 | 0.09 |
| 134_G | 317_K | 1.014 | 0.09 |
| 237_N | 251_A | 1.014 | 0.09 |
| 8_Y | 242_C | 1.014 | 0.09 |
| 320_L | 424_V | 1.014 | 0.09 |
| 265_Y | 482_K | 1.014 | 0.09 |
| 532_G | 923_L | 1.014 | 0.09 |
| 328_V | 337_F | 1.012 | 0.09 |
| 565_C | 827_E | 1.012 | 0.09 |
| 79_R | 797_Q | 1.011 | 0.09 |
| 437_F | 912_Q | 1.011 | 0.09 |
| 664_L | 667_M | 1.011 | 0.09 |
| 421_L | 902_E | 1.011 | 0.09 |
| 78_Y | 194_L | 1.011 | 0.09 |
| 52_M | 225_L | 1.010 | 0.09 |
| 397_T | 695_Q | 1.010 | 0.09 |
| 46_H | 413_G | 1.010 | 0.09 |
| 268_R | 622_L | 1.010 | 0.09 |
| 770_I | 787_K | 1.010 | 0.09 |
| 871_S | 874_S | 1.010 | 0.09 |
| 27_V | 178_S | 1.009 | 0.09 |
| 798_Y | 851_K | 1.007 | 0.09 |
| 40_G | 147_E | 1.006 | 0.09 |
| 617_P | 943_I | 1.006 | 0.09 |
| 556_E | 749_H | 1.006 | 0.09 |
| 449_K | 732_E | 1.006 | 0.09 |
| 192_K | 329_R | 1.006 | 0.09 |
| 294_C | 727_Q | 1.006 | 0.09 |
| 268_R | 441_S | 1.006 | 0.09 |
| 134_G | 422_L | 1.006 | 0.09 |
| 36_S | 952_V | 1.005 | 0.09 |
| 282_A | 295_L | 1.005 | 0.09 |
| 401_I | 519_K | 1.005 | 0.09 |
| 743_I | 917_V | 1.004 | 0.09 |
| 211_I | 738_E | 1.004 | 0.09 |
| 31_I | 352_L | 1.002 | 0.09 |
| 871_S | 912_Q | 1.002 | 0.09 |
| 630_M | 708_C | 1.002 | 0.09 |
| 134_G | 328_V | 1.002 | 0.09 |
| 451_L | 856_G | 1.001 | 0.09 |
| 444_S | 844_P | 1.001 | 0.09 |
| 315_S | 799_T | 1.001 | 0.09 |
| 107_P | 234_V | 1.000 | 0.09 |
| 383_R | 430_R | 1.000 | 0.09 |
| 391_E | 709_R | 1.000 | 0.09 |
| 780_R | 891_T | 1.000 | 0.09 |
| 615_P | 760_Y | 1.000 | 0.09 |
| 295_L | 770_I | 1.000 | 0.09 |
| 317_K | 523_L | 1.000 | 0.09 |
| 403_K | 807_E | 1.000 | 0.09 |
| 355_R | 451_L | 1.000 | 0.09 |
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
- Text file of contact predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
- Import to GREMLIN BETA - features includes ability to upload PDB and latest P(contact) calculation based on eLife 2015 fitting to PDB data.
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | M | Cov | P(%) | HHΔ | |
| 4oliA | 1 | 0.5534 | 100 | 0.745 | Contact Map |
| 4po6A | 1 | 0.3357 | 100 | 0.828 | Contact Map |
| 4e5wA | 2 | 0.3008 | 100 | 0.862 | Contact Map |
| 4fl3A | 1 | 0.5267 | 100 | 0.863 | Contact Map |
| 2ozoA | 1 | 0.5359 | 100 | 0.872 | Contact Map |
| 3ugcA | 1 | 0.2813 | 100 | 0.873 | Contact Map |
| 2w1iA | 2 | 0.2916 | 100 | 0.874 | Contact Map |
| 3lxpA | 1 | 0.2916 | 100 | 0.878 | Contact Map |
| 4rt7A | 1 | 0 | 100 | 0.881 | Contact Map |
| 1qcfA | 1 | 0.4507 | 100 | 0.885 | Contact Map |
Cov = coverage of hit
P(%) = probability
Sequence Conservation (Image Generated using WebLogo v3)