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OPENSEQ.org
450sequences-noiteration -force run
ID: 1441520866 Query Sequence

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 974 (972)
Sequences: 56 (24)
Seq/Len: 0.058
Nf(neff/√len): 0.8
HHblits Results: (2015_06)
Sequences per length for each position, BEFORE the coverage/gap filter was applied

Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 0.058).

Sequences per length for each position, AFTER the coverage/gap filter was applied
Legend: If visible, the positions blocked in grey are regions that have > 75% gaps and were automatically trimmed and excluded in the GREMLIN analysis.
Trim query Generate MSA using: Filter MSA GREMLIN
Start: End: E-value: Iterations: Coverage: Remove gaps: Prior:
GREMLIN Results:
Residue pairs sorted by coevolution strength:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.

ij Scaled score Prob
421_L750_D1.9310.26
60_Y298_K1.7640.21
580_S848_E1.7530.21
556_E748_Q1.7280.20
583_T756_K1.7010.19
249_D353_V1.6730.19
786_H943_I1.6560.18
36_S234_V1.6540.18
403_K853_K1.6350.18
180_E228_E1.6320.18
682_D750_D1.6150.17
687_E773_Y1.6030.17
80_I188_K1.5760.16
133_T457_V1.5720.16
482_K566_I1.5680.16
134_G796_L1.5490.16
278_F437_F1.5460.15
470_F738_E1.5450.15
164_N748_Q1.5450.15
304_Y828_N1.5450.15
280_T807_E1.5370.15
91_G786_H1.5160.15
256_K750_D1.5060.15
46_H50_A1.5060.15
517_C520_N1.4980.14
96_Y580_S1.4950.14
134_G350_N1.4810.14
187_H337_F1.4730.14
350_N796_L1.4700.14
437_F517_C1.4620.14
437_F520_N1.4620.14
274_F922_E1.4600.14
505_F580_S1.4540.13
134_G658_L1.4520.13
282_A490_L1.4470.13
350_N658_L1.4470.13
202_R304_Y1.4460.13
843_L868_L1.4360.13
278_F517_C1.4310.13
278_F520_N1.4310.13
658_L796_L1.4300.13
82_F422_L1.4250.13
12_G896_S1.4230.13
228_E657_L1.4160.13
224_Y759_C1.4160.13
80_I117_P1.4110.13
83_Y511_L1.4060.13
117_P173_A1.4040.13
424_V656_E1.3880.12
583_T693_F1.3870.12
287_N766_N1.3810.12
403_K941_Y1.3760.12
318_D521_I1.3740.12
215_Y835_G1.3740.12
69_D211_I1.3730.12
464_N482_K1.3730.12
309_T490_L1.3630.12
107_P556_E1.3630.12
189_Q276_K1.3490.12
503_M770_I1.3490.12
312_N555_Q1.3450.11
83_Y353_V1.3340.11
139_Q544_I1.3340.11
65_V860_I1.3300.11
402_F840_T1.3280.11
902_E905_R1.3260.11
78_Y118_G1.3230.11
277_Y785_K1.3200.11
778_S857_E1.3120.11
906_M922_E1.3100.11
782_Y814_Y1.3020.11
38_A274_F1.3020.11
749_H876_A1.2990.11
19_L80_I1.2960.11
575_A748_Q1.2960.11
508_E597_S1.2950.11
107_P748_Q1.2930.11
96_Y508_E1.2910.11
406_R633_E1.2850.10
102_R927_N1.2850.10
328_V337_F1.2830.10
31_I907_I1.2800.10
46_H78_Y1.2790.10
345_P401_I1.2790.10
186_I636_F1.2770.10
50_A78_Y1.2740.10
89_C328_V1.2710.10
88_Y556_E1.2710.10
549_L688_E1.2690.10
475_S748_Q1.2670.10
269_C756_K1.2660.10
20_T65_V1.2640.10
52_M674_F1.2610.10
131_I356_T1.2610.10
141_S508_E1.2610.10
96_Y505_F1.2610.10
291_Y523_L1.2590.10
481_K782_Y1.2590.10
406_R511_L1.2520.10
695_Q714_Q1.2520.10
750_D828_N1.2500.10
345_P682_D1.2480.10
42_T290_E1.2480.10
266_V458_C1.2450.10
165_I256_K1.2440.10
739_R795_L1.2440.10
180_E739_R1.2420.10
274_F414_Q1.2390.10
446_L748_Q1.2370.10
135_N298_K1.2360.10
643_I892_Y1.2360.10
748_Q876_A1.2360.10
21_F457_V1.2360.10
131_I219_A1.2340.10
275_N328_V1.2290.10
274_F544_I1.2290.10
693_F756_K1.2280.10
230_A574_L1.2280.10
475_S556_E1.2260.10
39_C436_F1.2230.09
304_Y851_K1.2200.09
50_A605_L1.2200.09
485_N505_F1.2200.09
452_V871_S1.2180.09
835_G845_Q1.2180.09
164_N556_E1.2180.09
660_E965_V1.2170.09
345_P750_D1.2130.09
408_E812_K1.2120.09
694_L714_Q1.2120.09
100_I337_F1.2120.09
390_N786_H1.2090.09
38_A786_H1.2070.09
475_S575_A1.2070.09
50_A424_V1.2050.09
50_A422_L1.2040.09
388_I966_D1.2040.09
578_K644_I1.2040.09
111_K258_A1.2040.09
353_V511_L1.2010.09
78_Y274_F1.1990.09
421_L682_D1.1970.09
76_V252_I1.1960.09
159_Y660_E1.1930.09
508_E810_G1.1930.09
544_I871_S1.1930.09
158_L265_Y1.1890.09
446_L556_E1.1890.09
44_V254_K1.1880.09
158_L402_F1.1860.09
643_I754_K1.1860.09
682_D905_R1.1860.09
511_L728_H1.1850.09
277_Y911_K1.1850.09
324_Q386_D1.1850.09
180_E657_L1.1830.09
517_C544_I1.1800.09
520_N544_I1.1800.09
69_D964_R1.1780.09
272_K437_F1.1770.09
756_K857_E1.1750.09
573_N812_K1.1750.09
857_E871_S1.1750.09
76_V458_C1.1750.09
318_D943_I1.1740.09
309_T633_E1.1740.09
187_H290_E1.1720.09
552_D603_R1.1690.09
172_Q320_L1.1690.09
26_Y893_I1.1670.09
69_D131_I1.1670.09
251_A279_L1.1670.09
146_K328_V1.1660.09
82_F605_L1.1640.09
221_A835_G1.1640.09
392_S552_D1.1640.09
429_H578_K1.1610.09
505_F828_N1.1590.09
317_K756_K1.1590.09
754_K773_Y1.1590.09
589_C707_M1.1580.09
648_N658_L1.1580.09
555_Q754_K1.1540.08
63_N585_L1.1540.08
413_G620_A1.1540.08
367_T603_R1.1530.08
44_V295_L1.1530.08
215_Y221_A1.1500.08
692_K790_I1.1460.08
189_Q746_S1.1460.08
169_S500_A1.1450.08
265_Y555_Q1.1450.08
482_K487_I1.1450.08
209_S639_S1.1450.08
47_N300_E1.1430.08
33_I815_I1.1420.08
533_N922_E1.1420.08
743_I868_L1.1400.08
417_E781_D1.1380.08
282_A309_T1.1380.08
249_D865_P1.1370.08
80_I249_D1.1350.08
180_E795_L1.1350.08
344_K932_R1.1350.08
418_T807_E1.1350.08
348_K552_D1.1320.08
320_L683_P1.1320.08
603_R681_R1.1310.08
556_E749_H1.1310.08
437_F544_I1.1290.08
117_P349_S1.1270.08
249_D448_H1.1260.08
78_Y163_P1.1260.08
743_I843_L1.1240.08
140_W952_V1.1230.08
328_V853_K1.1230.08
259_G401_I1.1230.08
209_S386_D1.1210.08
180_E201_L1.1210.08
234_V466_L1.1210.08
682_D902_E1.1190.08
643_I687_E1.1190.08
138_I764_R1.1190.08
687_E754_K1.1190.08
693_F766_N1.1180.08
209_S324_Q1.1180.08
272_K278_F1.1180.08
37_K44_V1.1160.08
56_E628_N1.1160.08
183_V571_N1.1160.08
100_I503_M1.1160.08
425_L778_S1.1160.08
330_S716_N1.1150.08
41_I962_A1.1150.08
328_V932_R1.1150.08
452_V906_M1.1150.08
780_R898_S1.1150.08
643_I773_Y1.1150.08
248_M408_E1.1130.08
416_H848_E1.1130.08
208_V479_Y1.1110.08
61_P134_G1.1110.08
113_E828_N1.1110.08
165_I422_L1.1080.08
252_I503_M1.1080.08
246_I280_T1.1080.08
517_C778_S1.1080.08
520_N778_S1.1080.08
211_I738_E1.1070.08
272_K517_C1.1070.08
272_K520_N1.1070.08
165_I707_M1.1070.08
521_I898_S1.1070.08
328_V490_L1.1050.08
83_Y248_M1.1050.08
61_P350_N1.1030.08
744_L829_E1.1030.08
508_E787_K1.1030.08
219_A597_S1.1030.08
552_D907_I1.1020.08
131_I211_I1.1020.08
464_N472_K1.1020.08
183_V481_K1.1020.08
209_S580_S1.1020.08
269_C583_T1.1020.08
215_Y845_Q1.1000.08
165_I750_D1.1000.08
9_H80_I1.1000.08
209_S814_Y1.0990.08
780_R868_L1.0970.08
392_S793_I1.0970.08
835_G893_I1.0970.08
96_Y209_S1.0950.08
103_G583_T1.0920.08
38_A599_L1.0910.08
96_Y482_K1.0910.08
45_Y181_S1.0910.08
201_L228_E1.0890.08
139_Q278_F1.0890.08
505_F807_E1.0890.08
78_Y199_S1.0890.08
598_A828_N1.0880.08
61_P82_F1.0880.08
50_A173_A1.0860.08
458_C730_T1.0860.08
656_E739_R1.0840.08
4_Q252_I1.0840.08
585_L746_S1.0840.08
273_D521_I1.0830.08
640_F827_E1.0830.08
278_F544_I1.0830.08
780_R843_L1.0810.08
83_Y406_R1.0810.08
185_T201_L1.0810.08
547_T791_D1.0810.08
61_P796_L1.0810.08
47_N164_N1.0800.08
315_S466_L1.0800.08
458_C745_K1.0800.08
249_D452_V1.0800.08
219_A716_N1.0800.08
516_V903_F1.0760.08
590_S599_L1.0760.08
69_D786_H1.0760.08
437_F778_S1.0760.08
211_I465_I1.0750.07
568_N786_H1.0750.07
52_M562_P1.0730.07
276_K746_S1.0730.07
472_K482_K1.0730.07
78_Y605_L1.0720.07
50_A421_L1.0720.07
366_P759_C1.0720.07
610_D770_I1.0720.07
403_K473_F1.0720.07
50_A118_G1.0720.07
240_S651_F1.0720.07
277_Y385_E1.0720.07
253_S473_F1.0700.07
408_E458_C1.0700.07
172_Q887_Y1.0700.07
91_G324_Q1.0700.07
400_K472_K1.0680.07
277_Y449_K1.0680.07
60_Y301_N1.0680.07
215_Y893_I1.0670.07
280_T490_L1.0670.07
381_K565_C1.0670.07
350_N648_N1.0650.07
328_V533_N1.0650.07
176_E482_K1.0650.07
280_T418_T1.0650.07
165_I902_E1.0640.07
401_I688_E1.0640.07
590_S781_D1.0620.07
30_E131_I1.0620.07
218_T251_A1.0600.07
914_Q959_R1.0600.07
146_K533_N1.0590.07
165_I606_Q1.0590.07
556_E876_A1.0590.07
228_E739_R1.0570.07
454_N842_V1.0570.07
287_N475_S1.0570.07
375_N754_K1.0570.07
26_Y891_T1.0570.07
475_S766_N1.0570.07
133_T674_F1.0560.07
251_A471_V1.0560.07
424_V906_M1.0540.07
397_T842_V1.0540.07
429_H644_I1.0540.07
475_S876_A1.0540.07
165_I421_L1.0540.07
196_I247_S1.0520.07
164_N421_L1.0510.07
103_G524_I1.0510.07
164_N576_T1.0490.07
311_K417_E1.0490.07
192_K756_K1.0490.07
172_Q683_P1.0490.07
895_K903_F1.0490.07
222_H348_K1.0490.07
429_H591_G1.0490.07
365_S519_K1.0480.07
57_R504_H1.0460.07
283_V551_K1.0460.07
278_F778_S1.0460.07
603_R907_I1.0460.07
353_V589_C1.0450.07
78_Y628_N1.0450.07
171_K652_T1.0450.07
347_D552_D1.0430.07
425_L594_K1.0430.07
274_F452_V1.0430.07
376_Q898_S1.0430.07
349_S494_E1.0430.07
76_V552_D1.0430.07
730_T900_P1.0410.07
251_A465_I1.0410.07
504_H668_R1.0410.07
139_Q517_C1.0410.07
139_Q520_N1.0410.07
219_A810_G1.0410.07
31_I898_S1.0410.07
78_Y902_E1.0400.07
484_K566_I1.0400.07
459_V904_M1.0400.07
208_V518_A1.0380.07
692_K902_E1.0380.07
376_Q642_A1.0380.07
274_F363_P1.0380.07
418_T500_A1.0370.07
47_N552_D1.0370.07
386_D778_S1.0370.07
422_L750_D1.0370.07
265_Y348_K1.0370.07
200_S432_Y1.0370.07
225_L397_T1.0370.07
225_L527_E1.0370.07
339_K424_V1.0370.07
107_P432_Y1.0370.07
391_E852_V1.0370.07
104_A252_I1.0350.07
453_L852_V1.0350.07
458_C511_L1.0350.07
91_G449_K1.0330.07
86_R487_I1.0320.07
106_A516_V1.0320.07
225_L714_Q1.0320.07
47_N414_Q1.0320.07
381_K835_G1.0320.07
389_F575_A1.0320.07
292_K741_I1.0320.07
375_N962_A1.0320.07
422_L810_G1.0300.07
761_S966_D1.0300.07
26_Y835_G1.0290.07
78_Y810_G1.0290.07
544_I912_Q1.0290.07
254_K688_E1.0290.07
408_E766_N1.0270.07
238_I596_L1.0270.07
321_N403_K1.0270.07
397_T674_F1.0270.07
78_Y682_D1.0270.07
616_A686_F1.0250.07
60_Y422_L1.0250.07
188_K417_E1.0240.07
668_R673_G1.0240.07
219_A508_E1.0240.07
840_T870_E1.0240.07
66_F393_L1.0240.07
42_T653_P1.0240.07
324_Q639_S1.0240.07
534_P887_Y1.0220.07
320_L887_Y1.0220.07
95_A309_T1.0220.07
86_R511_L1.0220.07
517_C912_Q1.0220.07
520_N912_Q1.0220.07
67_H851_K1.0220.07
82_F350_N1.0220.07
187_H676_G1.0210.07
169_S824_I1.0210.07
192_K941_Y1.0210.07
98_H403_K1.0210.07
256_K422_L1.0210.07
406_R735_R1.0210.07
256_K682_D1.0190.07
385_E925_K1.0190.07
88_Y475_S1.0190.07
503_M720_V1.0190.07
676_G695_Q1.0190.07
26_Y215_Y1.0190.07
646_D767_L1.0190.07
323_Y479_Y1.0170.07
60_Y643_I1.0170.07
544_I869_T1.0170.07
60_Y256_K1.0170.07
320_L739_R1.0170.07
363_P452_V1.0170.07
425_L857_E1.0170.07
25_E265_Y1.0160.07
554_L744_L1.0160.07
91_G313_F1.0160.07
392_S569_P1.0160.07
54_E739_R1.0140.07
472_K505_F1.0140.07
219_A969_R1.0140.07
117_P188_K1.0140.07
385_E916_I1.0140.07
385_E785_K1.0140.07
46_H118_G1.0140.07
238_I904_M1.0130.07
221_A547_T1.0130.07
256_K421_L1.0130.07
147_E734_L1.0130.07
117_P910_D1.0130.07
657_L683_P1.0110.07
239_Q915_M1.0110.07
517_C870_E1.0110.07
520_N870_E1.0110.07
288_V651_F1.0110.07
307_S916_I1.0110.07
128_A941_Y1.0110.07
275_N403_K1.0110.07
511_L600_D1.0110.07
248_M633_E1.0100.07
373_H959_R1.0100.07
71_S347_D1.0100.07
27_V100_I1.0100.07
88_Y293_H1.0080.07
101_S239_Q1.0080.07
446_L475_S1.0080.07
257_K305_N1.0080.07
83_Y478_T1.0060.07
511_L633_E1.0060.07
606_Q750_D1.0060.07
565_C898_S1.0060.07
186_I576_T1.0060.07
307_S734_L1.0060.07
8_Y785_K1.0060.07
78_Y544_I1.0060.07
197_E863_Y1.0060.07
377_M739_R1.0060.07
778_S840_T1.0060.07
377_M795_L1.0050.07
426_D848_E1.0050.07
395_Q738_E1.0050.07
164_N254_K1.0030.07
482_K589_C1.0030.07
46_H750_D1.0030.07
219_A361_D1.0030.07
290_E676_G1.0030.07
61_P171_K1.0030.07
215_Y821_T1.0030.07
639_S648_N1.0030.07
82_F134_G1.0020.07
189_Q840_T1.0020.07
790_I870_E1.0020.07
22_P628_N1.0020.07
253_S403_K1.0020.07
348_K898_S1.0020.07
321_N787_K1.0020.07
376_Q646_D1.0020.07
764_R782_Y1.0020.07
61_P658_L1.0000.07
321_N828_N1.0000.07
159_Y527_E1.0000.07
224_Y835_G1.0000.07
304_Y390_N1.0000.07
238_I551_K1.0000.07
277_Y738_E1.0000.07
Legend: Only predictions with Scaled Score > 1 are listed. For all 3L/2 predictions, click on one of the links below.
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
NEW Features 		HHsearch Results: (06Aug15)
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
PDB M Cov P(%) HHΔ  
4oliA10.55341000.783Contact Map
4po6A10.33261000.856Contact Map
4fl3A10.51751000.876Contact Map
4e5wA20.30081000.881Contact Map
3ugcA10.28131000.883Contact Map
2ozoA10.52361000.883Contact Map
2w1iA20.29161000.884Contact Map
4rt7A101000.894Contact Map
3lxpA10.29161000.896Contact Map
4otwA10.27311000.897Contact Map
M = number of chains, if homo-oligomer
Cov = coverage of hit
P(%) = probability
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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