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OPENSEQ.org
450sequences-coverage95 -force run
ID: 1441520791 Query Sequence

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 974 (973)
Sequences: 61 (27.7)
Seq/Len: 0.063
Nf(neff/√len): 0.9
HHblits Results: (2015_06)
Sequences per length for each position, BEFORE the coverage/gap filter was applied

Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 0.063).

Sequences per length for each position, AFTER the coverage/gap filter was applied
Legend: If visible, the positions blocked in grey are regions that have > 75% gaps and were automatically trimmed and excluded in the GREMLIN analysis.
Trim query Generate MSA using: Filter MSA GREMLIN
Start: End: E-value: Iterations: Coverage: Remove gaps: Prior:
GREMLIN Results:
Residue pairs sorted by coevolution strength:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.

ij Scaled score Prob
421_L750_D2.1340.36
256_K750_D1.7530.22
482_K566_I1.7080.21
517_C520_N1.6880.20
583_T756_K1.6830.20
403_K853_K1.6710.20
215_Y893_I1.6540.19
180_E228_E1.6510.19
83_Y511_L1.6380.19
580_S848_E1.5960.18
782_Y814_Y1.5790.17
556_E748_Q1.5760.17
38_A274_F1.5710.17
60_Y298_K1.5680.17
133_T457_V1.5610.17
505_F580_S1.5500.16
46_H78_Y1.5450.16
82_F422_L1.5430.16
749_H876_A1.5370.16
470_F738_E1.5340.16
390_N786_H1.5300.16
134_G796_L1.5230.16
437_F517_C1.5140.16
437_F520_N1.5140.16
786_H943_I1.5060.15
69_D211_I1.4830.15
265_Y555_Q1.4780.15
345_P682_D1.4750.15
228_E657_L1.4600.14
46_H50_A1.4580.14
644_I846_D1.4540.14
164_N556_E1.4460.14
83_Y353_V1.4440.14
215_Y821_T1.4430.14
44_V295_L1.4430.14
739_R795_L1.4320.14
668_R673_G1.4160.13
403_K941_Y1.4100.13
76_V458_C1.4040.13
259_G401_I1.4040.13
164_N748_Q1.4010.13
50_A422_L1.3850.13
282_A490_L1.3840.13
304_Y828_N1.3760.13
50_A78_Y1.3670.12
643_I754_K1.3670.12
225_L397_T1.3600.12
671_A674_F1.3600.12
209_S580_S1.3600.12
208_V315_S1.3570.12
468_Q479_Y1.3570.12
89_C328_V1.3560.12
50_A118_G1.3540.12
66_F185_T1.3530.12
620_A824_I1.3530.12
821_T893_I1.3510.12
102_R927_N1.3460.12
682_D750_D1.3450.12
328_V337_F1.3430.12
228_E739_R1.3430.12
249_D353_V1.3400.12
63_N585_L1.3390.12
50_A424_V1.3330.12
344_K770_I1.3310.12
80_I188_K1.3290.12
437_F544_I1.3260.12
743_I868_L1.3220.12
196_I750_D1.3190.12
117_P173_A1.3120.11
516_V903_F1.3060.11
202_R304_Y1.3030.11
278_F437_F1.3030.11
134_G350_N1.3000.11
21_F457_V1.2970.11
375_N754_K1.2940.11
517_C778_S1.2920.11
520_N778_S1.2920.11
209_S386_D1.2880.11
165_I707_M1.2860.11
186_I636_F1.2770.11
402_F840_T1.2770.11
130_I860_I1.2740.11
568_N786_H1.2720.11
165_I422_L1.2700.11
475_S748_Q1.2700.11
45_Y860_I1.2700.11
694_L714_Q1.2690.11
225_L589_C1.2670.11
575_A748_Q1.2630.11
224_Y799_T1.2610.11
192_K824_I1.2580.10
52_M674_F1.2550.10
180_E657_L1.2550.10
376_Q646_D1.2550.10
425_L778_S1.2550.10
287_N766_N1.2550.10
902_E905_R1.2530.10
795_L887_Y1.2500.10
164_N421_L1.2490.10
508_E810_G1.2440.10
375_N464_N1.2410.10
304_Y390_N1.2380.10
91_G786_H1.2360.10
475_S556_E1.2360.10
215_Y845_Q1.2360.10
309_T490_L1.2350.10
180_E739_R1.2330.10
36_S234_V1.2330.10
159_Y527_E1.2320.10
76_V252_I1.2300.10
701_N727_Q1.2300.10
256_K421_L1.2300.10
318_D521_I1.2290.10
401_I533_N1.2250.10
78_Y810_G1.2250.10
353_V511_L1.2250.10
704_S867_S1.2240.10
458_C511_L1.2240.10
33_I374_M1.2220.10
269_C756_K1.2220.10
187_H290_E1.2220.10
397_T589_C1.2220.10
219_A265_Y1.2210.10
278_F517_C1.2190.10
278_F520_N1.2190.10
317_K756_K1.2190.10
98_H464_N1.2190.10
318_D333_I1.2180.10
222_H568_N1.2150.10
221_A835_G1.2150.10
267_L828_N1.2130.10
47_N414_Q1.2120.10
192_K941_Y1.2100.10
481_K785_K1.2070.10
96_Y508_E1.2070.10
475_S876_A1.2050.10
67_H851_K1.2020.10
88_Y556_E1.1990.10
475_S575_A1.1980.10
326_E812_K1.1980.10
583_T693_F1.1960.09
353_V576_T1.1940.09
503_M770_I1.1940.09
320_L739_R1.1940.09
517_C544_I1.1940.09
520_N544_I1.1940.09
544_I871_S1.1940.09
273_D521_I1.1940.09
376_Q898_S1.1930.09
943_I951_N1.1930.09
452_V906_M1.1910.09
159_Y694_L1.1900.09
350_N796_L1.1880.09
96_Y580_S1.1880.09
117_P349_S1.1880.09
37_K44_V1.1880.09
366_P759_C1.1880.09
76_V505_F1.1850.09
42_T55_T1.1850.09
770_I787_K1.1850.09
575_A876_A1.1840.09
280_T807_E1.1840.09
277_Y785_K1.1820.09
429_H578_K1.1800.09
845_Q893_I1.1800.09
107_P556_E1.1800.09
778_S857_E1.1800.09
274_F452_V1.1790.09
187_H337_F1.1790.09
77_L544_I1.1790.09
189_Q276_K1.1770.09
31_I907_I1.1770.09
640_F743_I1.1770.09
192_K458_C1.1760.09
168_V249_D1.1730.09
83_Y248_M1.1710.09
274_F922_E1.1710.09
505_F807_E1.1710.09
165_I682_D1.1700.09
413_G620_A1.1700.09
78_Y237_N1.1670.09
264_L815_I1.1670.09
417_E781_D1.1670.09
739_R887_Y1.1650.09
78_Y605_L1.1650.09
345_P401_I1.1630.09
275_N966_D1.1630.09
295_L750_D1.1630.09
455_Y840_T1.1620.09
80_I117_P1.1620.09
211_I738_E1.1620.09
835_G914_Q1.1600.09
388_I966_D1.1590.09
208_V518_A1.1590.09
266_V458_C1.1570.09
107_P748_Q1.1570.09
274_F544_I1.1570.09
556_E749_H1.1540.09
219_A508_E1.1530.09
367_T603_R1.1530.09
304_Y851_K1.1510.09
376_Q642_A1.1510.09
249_D448_H1.1490.09
565_C898_S1.1480.09
446_L556_E1.1480.09
455_Y583_T1.1460.09
406_R633_E1.1430.09
508_E787_K1.1430.09
555_Q754_K1.1430.09
406_R511_L1.1420.09
369_Q583_T1.1420.09
83_Y516_V1.1390.09
640_F868_L1.1390.09
437_F455_Y1.1390.09
140_W952_V1.1360.09
60_Y643_I1.1360.09
485_N505_F1.1360.09
785_K925_K1.1320.09
475_S749_H1.1320.09
189_Q756_K1.1320.09
418_T505_F1.1310.09
437_F778_S1.1290.09
748_Q876_A1.1290.09
446_L455_Y1.1260.08
640_F891_T1.1260.08
192_K344_K1.1260.08
648_N658_L1.1260.08
312_N555_Q1.1250.08
342_P580_S1.1250.08
508_E597_S1.1250.08
165_I280_T1.1230.08
215_Y835_G1.1220.08
556_E876_A1.1200.08
658_L796_L1.1200.08
78_Y274_F1.1180.08
82_F134_G1.1180.08
42_T290_E1.1170.08
272_K437_F1.1170.08
693_F756_K1.1170.08
277_Y911_K1.1150.08
219_A361_D1.1150.08
221_A547_T1.1150.08
357_N814_Y1.1140.08
249_D865_P1.1140.08
76_V552_D1.1140.08
252_I369_Q1.1140.08
211_I694_L1.1120.08
687_E773_Y1.1120.08
196_I256_K1.1120.08
45_Y402_F1.1110.08
695_Q714_Q1.1110.08
12_G896_S1.1090.08
165_I345_P1.1090.08
275_N403_K1.1090.08
455_Y544_I1.1090.08
446_L748_Q1.1080.08
426_D848_E1.1080.08
448_H865_P1.1060.08
366_P919_H1.1040.08
660_E965_V1.1040.08
78_Y682_D1.1040.08
476_L588_I1.1040.08
56_E252_I1.1040.08
349_S891_T1.1030.08
238_I596_L1.1030.08
50_A682_D1.1030.08
191_G508_E1.1030.08
209_S814_Y1.1030.08
458_C730_T1.1030.08
640_F646_D1.1030.08
317_K583_T1.1010.08
170_I829_E1.1010.08
192_K756_K1.1000.08
280_T424_V1.1000.08
183_V785_K1.1000.08
224_Y759_C1.1000.08
114_V631_D1.1000.08
8_Y455_Y1.0970.08
692_K868_L1.0970.08
141_S508_E1.0970.08
113_E828_N1.0950.08
843_L868_L1.0950.08
235_L561_V1.0940.08
282_A589_C1.0940.08
183_V481_K1.0940.08
511_L633_E1.0940.08
282_A750_D1.0920.08
397_T674_F1.0910.08
780_R843_L1.0910.08
640_F827_E1.0910.08
168_V932_R1.0890.08
565_C640_F1.0890.08
139_Q517_C1.0870.08
139_Q520_N1.0870.08
318_D943_I1.0870.08
74_H200_S1.0870.08
626_I764_R1.0860.08
88_Y475_S1.0840.08
275_N328_V1.0840.08
346_K647_L1.0840.08
444_S451_L1.0830.08
134_G658_L1.0830.08
172_Q320_L1.0830.08
4_Q252_I1.0830.08
135_N298_K1.0830.08
228_E795_L1.0830.08
96_Y505_F1.0810.08
264_L781_D1.0810.08
131_I356_T1.0800.08
323_Y479_Y1.0800.08
39_C436_F1.0800.08
215_Y221_A1.0800.08
418_T807_E1.0800.08
887_Y902_E1.0800.08
22_P628_N1.0780.08
548_V798_Y1.0780.08
434_E764_R1.0770.08
86_R281_F1.0770.08
12_G146_K1.0770.08
320_L887_Y1.0770.08
744_L829_E1.0750.08
347_D465_I1.0750.08
191_G402_F1.0730.08
766_N821_T1.0700.08
82_F707_M1.0700.08
139_Q544_I1.0700.08
292_K544_I1.0700.08
527_E714_Q1.0690.08
57_R504_H1.0690.08
253_S957_S1.0690.08
274_F344_K1.0690.08
511_L728_H1.0690.08
224_Y496_A1.0690.08
36_S89_C1.0670.08
19_L102_R1.0670.08
344_K932_R1.0670.08
547_T791_D1.0660.08
52_M589_C1.0660.08
239_Q915_M1.0660.08
386_D778_S1.0660.08
547_T642_A1.0660.08
590_S599_L1.0660.08
281_F527_E1.0660.08
452_V871_S1.0640.08
455_Y555_Q1.0640.08
131_I211_I1.0640.08
389_F575_A1.0630.08
470_F483_N1.0630.08
275_N414_Q1.0630.08
128_A941_Y1.0630.08
349_S903_F1.0610.08
111_K258_A1.0590.08
743_I891_T1.0580.08
82_F89_C1.0560.08
45_Y181_S1.0560.08
333_I421_L1.0560.08
350_N422_L1.0560.08
182_R435_S1.0560.08
524_I766_N1.0560.08
464_N517_C1.0560.08
464_N520_N1.0560.08
349_S745_K1.0550.08
158_L402_F1.0550.08
41_I962_A1.0550.08
590_S781_D1.0550.08
603_R907_I1.0530.08
19_L80_I1.0530.08
422_L707_M1.0530.08
49_F190_D1.0530.08
552_D603_R1.0530.08
756_K778_S1.0530.08
756_K857_E1.0530.08
424_V906_M1.0520.08
280_T345_P1.0520.08
693_F766_N1.0520.08
565_C743_I1.0520.08
159_Y660_E1.0520.08
778_S814_Y1.0520.08
475_S766_N1.0500.07
857_E871_S1.0500.07
169_S824_I1.0500.07
22_P446_L1.0490.07
521_I941_Y1.0490.07
465_I782_Y1.0490.07
882_F892_Y1.0490.07
640_F898_S1.0490.07
392_S552_D1.0490.07
789_R922_E1.0470.07
835_G891_T1.0470.07
376_Q565_C1.0470.07
182_R615_P1.0460.07
185_T228_E1.0440.07
309_T633_E1.0440.07
455_Y814_Y1.0440.07
272_K517_C1.0440.07
272_K520_N1.0440.07
906_M922_E1.0440.07
280_T790_I1.0440.07
180_E795_L1.0420.07
165_I606_Q1.0420.07
347_D552_D1.0420.07
287_N475_S1.0410.07
603_R681_R1.0410.07
103_G583_T1.0390.07
780_R898_S1.0390.07
76_V321_N1.0390.07
69_D403_K1.0380.07
118_G571_N1.0380.07
238_I428_A1.0380.07
565_C683_P1.0360.07
566_I773_Y1.0360.07
219_A810_G1.0360.07
517_C851_K1.0350.07
520_N851_K1.0350.07
548_V952_V1.0350.07
254_K549_L1.0350.07
330_S716_N1.0350.07
65_V860_I1.0350.07
200_S913_G1.0330.07
472_K482_K1.0330.07
646_D743_I1.0330.07
633_E965_V1.0330.07
163_P173_A1.0330.07
527_E694_L1.0330.07
59_W806_M1.0320.07
800_S860_I1.0320.07
780_R868_L1.0300.07
276_K746_S1.0300.07
464_N790_I1.0300.07
642_A646_D1.0300.07
643_I687_E1.0300.07
835_G893_I1.0300.07
376_Q547_T1.0300.07
122_S828_N1.0300.07
254_K422_L1.0300.07
687_E754_K1.0300.07
221_A433_S1.0300.07
422_L682_D1.0300.07
425_L594_K1.0280.07
274_F363_P1.0270.07
546_I914_Q1.0270.07
585_L596_L1.0270.07
248_M353_V1.0270.07
425_L517_C1.0250.07
425_L520_N1.0250.07
490_L589_C1.0250.07
5_V275_N1.0250.07
12_G957_S1.0240.07
238_I573_N1.0240.07
311_K617_P1.0240.07
83_Y225_L1.0240.07
868_L891_T1.0240.07
159_Y281_F1.0220.07
27_V741_I1.0220.07
78_Y93_N1.0220.07
63_N835_G1.0220.07
188_K906_M1.0220.07
73_R295_L1.0210.07
188_K939_E1.0210.07
221_A642_A1.0210.07
272_K278_F1.0210.07
239_Q671_A1.0210.07
311_K417_E1.0210.07
743_I827_E1.0210.07
196_I247_S1.0190.07
575_A749_H1.0190.07
30_E508_E1.0190.07
835_G845_Q1.0190.07
192_K511_L1.0190.07
38_A599_L1.0180.07
83_Y406_R1.0180.07
282_A309_T1.0180.07
490_L750_D1.0180.07
421_L475_S1.0160.07
353_V589_C1.0160.07
26_Y891_T1.0160.07
83_Y186_I1.0160.07
267_L391_E1.0160.07
52_M562_P1.0160.07
549_L688_E1.0160.07
406_R735_R1.0160.07
517_C912_Q1.0150.07
520_N912_Q1.0150.07
472_K505_F1.0150.07
246_I280_T1.0150.07
521_I898_S1.0150.07
458_C745_K1.0130.07
692_K743_I1.0130.07
248_M511_L1.0130.07
159_Y714_Q1.0110.07
320_L683_P1.0110.07
69_D787_K1.0100.07
581_F752_I1.0100.07
26_Y827_E1.0100.07
278_F968_I1.0100.07
424_V656_E1.0100.07
240_S519_K1.0100.07
82_F796_L1.0100.07
33_I733_H1.0100.07
95_A406_R1.0080.07
70_E265_Y1.0080.07
470_F911_K1.0080.07
610_D668_R1.0070.07
52_M225_L1.0070.07
100_I503_M1.0070.07
682_D692_K1.0070.07
66_F453_L1.0050.07
240_S448_H1.0050.07
376_Q640_F1.0050.07
286_E470_F1.0050.07
328_V490_L1.0050.07
392_S553_I1.0050.07
86_R562_P1.0050.07
46_H810_G1.0040.07
435_S701_N1.0040.07
435_S727_Q1.0040.07
770_I824_I1.0040.07
430_R547_T1.0040.07
328_V533_N1.0020.07
374_M455_Y1.0020.07
575_A589_C1.0020.07
7_L40_G1.0010.07
225_L288_V1.0010.07
193_N442_M1.0010.07
165_I527_E1.0010.07
248_M773_Y1.0010.07
482_K745_K1.0010.07
455_Y571_N1.0010.07
Legend: Only predictions with Scaled Score > 1 are listed. For all 3L/2 predictions, click on one of the links below.
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
NEW Features 		HHsearch Results: (06Aug15)
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
PDB M Cov P(%) HHΔ  
4oliA10.55341000.766Contact Map
4po6A10.33261000.843Contact Map
4fl3A10.52161000.871Contact Map
4e5wA20.30081000.873Contact Map
3ugcA10.28131000.879Contact Map
2ozoA10.53181000.88Contact Map
2w1iA20.29161000.88Contact Map
4rt7A101000.889Contact Map
3lxpA10.29161000.889Contact Map
1qcfA10.45071000.891Contact Map
M = number of chains, if homo-oligomer
Cov = coverage of hit
P(%) = probability
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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