| acrB |
| ID: | 1411671266 |
Query Sequence |
Download Alignment We filter this alignment to remove positions that have > 75% gaps before running GREMLIN. |
| Length: | 1031 (1018) | ||
| Sequences: | 7818 (5432) | ||
| Seq/Len: | 7.680 | ||
| Nf(neff/√len): | 170.2 |
HHblits Results: (2013_03)
Sequences per length for each position, BEFORE the coverage/gap filter was applied
Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 7.680).
Sequences per length for each position, AFTER the coverage/gap filter was applied
Residue pairs sorted by coevolution strength:
Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.
| i | j | Scaled score | Prob |
| 243_E | 246_G | 4.450 | 1.00 |
| 958_G | 961_E | 4.285 | 1.00 |
| 310_A | 313_E | 4.158 | 1.00 |
| 308_E | 311_K | 4.107 | 1.00 |
| 61_T | 87_V | 4.047 | 1.00 |
| 246_G | 262_R | 3.956 | 1.00 |
| 729_D | 807_R | 3.935 | 1.00 |
| 46_A | 87_V | 3.775 | 1.00 |
| 247_K | 262_R | 3.600 | 1.00 |
| 914_A | 1008_G | 3.585 | 1.00 |
| 529_S | 1019_F | 3.537 | 1.00 |
| 303_A | 333_K | 3.440 | 1.00 |
| 585_R | 588_K | 3.339 | 1.00 |
| 590_L | 624_G | 3.315 | 1.00 |
| 531_G | 964_L | 3.261 | 1.00 |
| 2_N | 6_D | 3.203 | 1.00 |
| 730_I | 735_A | 3.083 | 1.00 |
| 735_A | 745_I | 3.008 | 1.00 |
| 141_V | 157_V | 2.999 | 1.00 |
| 187_M | 202_V | 2.985 | 1.00 |
| 149_T | 152_D | 2.974 | 1.00 |
| 425_P | 428_E | 2.971 | 1.00 |
| 306_R | 327_D | 2.925 | 1.00 |
| 759_N | 770_V | 2.907 | 1.00 |
| 74_L | 91_L | 2.898 | 1.00 |
| 57_Q | 822_P | 2.883 | 1.00 |
| 192_L | 197_L | 2.877 | 1.00 |
| 731_D | 805_S | 2.861 | 1.00 |
| 246_G | 267_I | 2.860 | 1.00 |
| 250_L | 264_V | 2.722 | 1.00 |
| 164_A | 308_E | 2.717 | 1.00 |
| 741_S | 744_D | 2.713 | 1.00 |
| 168_T | 304_A | 2.705 | 1.00 |
| 61_T | 81_S | 2.678 | 1.00 |
| 313_E | 321_K | 2.677 | 1.00 |
| 693_K | 696_Q | 2.654 | 1.00 |
| 690_G | 693_K | 2.633 | 1.00 |
| 281_N | 607_S | 2.603 | 1.00 |
| 242_T | 246_G | 2.576 | 1.00 |
| 423_G | 432_K | 2.554 | 1.00 |
| 704_E | 707_K | 2.536 | 1.00 |
| 377_G | 479_L | 2.531 | 1.00 |
| 344_V | 348_I | 2.511 | 1.00 |
| 188_N | 191_E | 2.500 | 1.00 |
| 153_I | 320_L | 2.496 | 1.00 |
| 261_L | 267_I | 2.485 | 1.00 |
| 697_A | 854_V | 2.463 | 1.00 |
| 731_D | 734_K | 2.447 | 1.00 |
| 957_K | 965_D | 2.425 | 1.00 |
| 279_E | 594_T | 2.424 | 1.00 |
| 75_M | 94_E | 2.405 | 1.00 |
| 587_Q | 591_N | 2.361 | 1.00 |
| 632_D | 635_D | 2.332 | 1.00 |
| 601_E | 653_A | 2.328 | 1.00 |
| 75_M | 92_T | 2.323 | 1.00 |
| 918_R | 1004_T | 2.308 | 1.00 |
| 185_I | 206_I | 2.283 | 1.00 |
| 535_R | 960_I | 2.281 | 1.00 |
| 896_I | 949_K | 2.276 | 1.00 |
| 527_T | 968_R | 2.273 | 1.00 |
| 696_Q | 700_Q | 2.260 | 1.00 |
| 381_V | 475_S | 2.255 | 1.00 |
| 341_K | 345_E | 2.251 | 1.00 |
| 728_I | 804_S | 2.236 | 1.00 |
| 156_Y | 320_L | 2.235 | 1.00 |
| 597_Y | 650_A | 2.171 | 1.00 |
| 192_L | 264_V | 2.168 | 1.00 |
| 203_I | 772_V | 2.151 | 1.00 |
| 187_M | 199_P | 2.150 | 1.00 |
| 300_D | 304_A | 2.142 | 1.00 |
| 729_D | 805_S | 2.138 | 1.00 |
| 799_P | 802_A | 2.137 | 1.00 |
| 730_I | 745_I | 2.130 | 1.00 |
| 181_Y | 269_L | 2.116 | 1.00 |
| 573_T | 628_V | 2.110 | 1.00 |
| 642_K | 645_A | 2.107 | 1.00 |
| 245_F | 261_L | 2.102 | 1.00 |
| 64_I | 89_I | 2.100 | 1.00 |
| 577_L | 581_A | 2.077 | 1.00 |
| 64_I | 68_M | 2.076 | 1.00 |
| 783_D | 786_G | 2.075 | 1.00 |
| 54_K | 58_D | 2.046 | 1.00 |
| 989_V | 1007_M | 2.028 | 1.00 |
| 727_K | 809_E | 2.018 | 1.00 |
| 708_H | 842_L | 2.006 | 1.00 |
| 56_V | 60_V | 2.001 | 1.00 |
| 418_V | 436_Q | 2.000 | 1.00 |
| 9_I | 888_A | 1.994 | 1.00 |
| 844_E | 866_R | 1.985 | 1.00 |
| 963_T | 1026_V | 1.981 | 1.00 |
| 702_L | 706_A | 1.973 | 1.00 |
| 679_F | 828_G | 1.973 | 1.00 |
| 536_S | 539_R | 1.971 | 1.00 |
| 705_A | 843_M | 1.970 | 1.00 |
| 834_K | 842_L | 1.961 | 1.00 |
| 786_G | 801_S | 1.961 | 1.00 |
| 243_E | 247_K | 1.950 | 1.00 |
| 546_I | 550_G | 1.940 | 1.00 |
| 414_N | 436_Q | 1.938 | 1.00 |
| 370_A | 483_V | 1.933 | 1.00 |
| 841_E | 844_E | 1.908 | 1.00 |
| 711_M | 715_V | 1.904 | 1.00 |
| 186_W | 268_E | 1.896 | 1.00 |
| 68_M | 89_I | 1.895 | 1.00 |
| 711_M | 839_A | 1.894 | 1.00 |
| 714_S | 829_Q | 1.890 | 1.00 |
| 835_S | 838_E | 1.887 | 1.00 |
| 532_G | 536_S | 1.885 | 1.00 |
| 649_R | 653_A | 1.884 | 1.00 |
| 702_L | 715_V | 1.869 | 1.00 |
| 740_V | 790_V | 1.857 | 1.00 |
| 337_H | 341_K | 1.854 | 1.00 |
| 532_G | 535_R | 1.850 | 1.00 |
| 198_T | 201_D | 1.835 | 1.00 |
| 606_E | 631_K | 1.833 | 1.00 |
| 387_F | 471_I | 1.829 | 1.00 |
| 699_N | 702_L | 1.823 | 1.00 |
| 704_E | 849_K | 1.818 | 1.00 |
| 141_V | 161_M | 1.813 | 1.00 |
| 197_L | 201_D | 1.800 | 1.00 |
| 960_I | 1026_V | 1.790 | 1.00 |
| 68_M | 91_L | 1.786 | 1.00 |
| 952_M | 1025_F | 1.785 | 1.00 |
| 734_K | 737_A | 1.783 | 1.00 |
| 698_R | 824_M | 1.777 | 1.00 |
| 161_M | 312_M | 1.774 | 1.00 |
| 951_L | 955_E | 1.769 | 1.00 |
| 182_A | 771_Y | 1.768 | 1.00 |
| 23_G | 27_L | 1.765 | 1.00 |
| 428_E | 432_K | 1.763 | 1.00 |
| 203_I | 207_K | 1.749 | 1.00 |
| 266_K | 775_E | 1.748 | 1.00 |
| 592_E | 595_H | 1.743 | 1.00 |
| 241_S | 244_E | 1.740 | 1.00 |
| 7_R | 892_E | 1.733 | 1.00 |
| 478_A | 482_L | 1.732 | 1.00 |
| 417_R | 969_M | 1.723 | 1.00 |
| 575_V | 593_V | 1.722 | 1.00 |
| 77_M | 91_L | 1.713 | 1.00 |
| 240_T | 244_E | 1.713 | 1.00 |
| 702_L | 717_P | 1.712 | 1.00 |
| 210_N | 759_N | 1.709 | 1.00 |
| 206_I | 248_I | 1.707 | 1.00 |
| 304_A | 307_A | 1.701 | 1.00 |
| 697_A | 700_Q | 1.700 | 1.00 |
| 189_P | 778_Y | 1.700 | 1.00 |
| 144_T | 321_K | 1.699 | 1.00 |
| 537_T | 1026_V | 1.698 | 1.00 |
| 521_K | 524_H | 1.697 | 1.00 |
| 701_L | 847_A | 1.691 | 1.00 |
| 61_T | 79_S | 1.688 | 1.00 |
| 834_K | 838_E | 1.685 | 1.00 |
| 526_Y | 967_V | 1.684 | 1.00 |
| 279_E | 587_Q | 1.677 | 1.00 |
| 187_M | 192_L | 1.674 | 1.00 |
| 19_M | 376_L | 1.670 | 1.00 |
| 949_K | 954_K | 1.669 | 1.00 |
| 951_L | 957_K | 1.662 | 1.00 |
| 775_E | 778_Y | 1.661 | 1.00 |
| 28_K | 383_A | 1.660 | 1.00 |
| 602_K | 649_R | 1.657 | 1.00 |
| 740_V | 803_F | 1.654 | 1.00 |
| 541_L | 545_L | 1.651 | 1.00 |
| 449_S | 478_A | 1.647 | 1.00 |
| 73_N | 97_T | 1.644 | 1.00 |
| 46_A | 61_T | 1.638 | 1.00 |
| 65_E | 817_R | 1.638 | 1.00 |
| 781_L | 784_D | 1.636 | 1.00 |
| 590_L | 610_A | 1.635 | 1.00 |
| 300_D | 303_A | 1.631 | 1.00 |
| 700_Q | 703_A | 1.621 | 1.00 |
| 703_A | 707_K | 1.619 | 1.00 |
| 920_L | 1004_T | 1.619 | 1.00 |
| 471_I | 475_S | 1.616 | 1.00 |
| 60_V | 121_V | 1.614 | 1.00 |
| 790_V | 803_F | 1.606 | 1.00 |
| 171_V | 290_I | 1.605 | 1.00 |
| 571_F | 628_V | 1.601 | 1.00 |
| 641_N | 649_R | 1.601 | 1.00 |
| 710_D | 842_L | 1.601 | 1.00 |
| 418_V | 423_G | 1.598 | 1.00 |
| 735_A | 740_V | 1.594 | 1.00 |
| 2_N | 431_R | 1.594 | 1.00 |
| 142_I | 323_V | 1.593 | 1.00 |
| 385_F | 475_S | 1.585 | 1.00 |
| 188_N | 266_K | 1.579 | 1.00 |
| 553_Y | 556_V | 1.578 | 1.00 |
| 303_A | 307_A | 1.578 | 1.00 |
| 25_A | 380_A | 1.576 | 1.00 |
| 596_Y | 653_A | 1.572 | 1.00 |
| 597_Y | 605_V | 1.571 | 1.00 |
| 651_T | 714_S | 1.568 | 1.00 |
| 695_T | 699_N | 1.568 | 1.00 |
| 414_N | 417_R | 1.560 | 1.00 |
| 884_F | 897_P | 1.553 | 1.00 |
| 44_I | 68_M | 1.550 | 1.00 |
| 903_V | 941_A | 1.549 | 1.00 |
| 296_A | 301_T | 1.548 | 1.00 |
| 745_I | 803_F | 1.548 | 1.00 |
| 309_L | 322_I | 1.548 | 1.00 |
| 521_K | 525_H | 1.548 | 1.00 |
| 381_V | 385_F | 1.530 | 1.00 |
| 648_M | 652_R | 1.530 | 1.00 |
| 378_T | 476_A | 1.525 | 1.00 |
| 148_M | 319_G | 1.523 | 1.00 |
| 81_S | 87_V | 1.517 | 1.00 |
| 591_N | 595_H | 1.517 | 1.00 |
| 693_K | 697_A | 1.517 | 1.00 |
| 602_K | 653_A | 1.516 | 1.00 |
| 13_V | 885_L | 1.512 | 1.00 |
| 338_E | 341_K | 1.507 | 0.99 |
| 631_K | 635_D | 1.505 | 0.99 |
| 200_V | 204_T | 1.504 | 0.99 |
| 758_V | 772_V | 1.503 | 0.99 |
| 204_T | 207_K | 1.502 | 0.99 |
| 698_R | 717_P | 1.500 | 0.99 |
| 527_T | 531_G | 1.498 | 0.99 |
| 727_K | 807_R | 1.496 | 0.99 |
| 155_D | 768_K | 1.496 | 0.99 |
| 411_V | 434_M | 1.491 | 0.99 |
| 529_S | 532_G | 1.489 | 0.99 |
| 951_L | 965_D | 1.483 | 0.99 |
| 198_T | 791_R | 1.481 | 0.99 |
| 44_I | 91_L | 1.480 | 0.99 |
| 728_I | 806_S | 1.480 | 0.99 |
| 239_L | 245_F | 1.480 | 0.99 |
| 68_M | 106_V | 1.479 | 0.99 |
| 560_S | 837_G | 1.479 | 0.99 |
| 140_G | 280_F | 1.476 | 0.99 |
| 581_A | 585_R | 1.470 | 0.99 |
| 91_L | 106_V | 1.469 | 0.99 |
| 703_A | 706_A | 1.466 | 0.99 |
| 64_I | 113_A | 1.465 | 0.99 |
| 351_F | 368_T | 1.465 | 0.99 |
| 128_V | 135_F | 1.464 | 0.99 |
| 26_I | 340_V | 1.462 | 0.99 |
| 960_I | 964_L | 1.459 | 0.99 |
| 33_Q | 568_Q | 1.455 | 0.99 |
| 838_E | 841_E | 1.455 | 0.99 |
| 98_D | 101_I | 1.450 | 0.99 |
| 575_V | 590_L | 1.447 | 0.99 |
| 6_D | 427_K | 1.444 | 0.99 |
| 842_L | 845_Q | 1.438 | 0.99 |
| 348_I | 352_L | 1.437 | 0.99 |
| 548_V | 552_A | 1.434 | 0.99 |
| 306_R | 324_Y | 1.425 | 0.99 |
| 864_Q | 867_L | 1.424 | 0.99 |
| 233_I | 753_W | 1.419 | 0.99 |
| 604_N | 646_I | 1.411 | 0.99 |
| 247_K | 260_L | 1.406 | 0.99 |
| 982_I | 1007_M | 1.405 | 0.99 |
| 418_V | 421_E | 1.404 | 0.99 |
| 244_E | 247_K | 1.404 | 0.99 |
| 204_T | 208_A | 1.401 | 0.99 |
| 239_L | 248_I | 1.398 | 0.99 |
| 982_I | 1011_V | 1.397 | 0.99 |
| 73_N | 94_E | 1.395 | 0.99 |
| 417_R | 421_E | 1.393 | 0.99 |
| 130_K | 135_F | 1.393 | 0.99 |
| 97_T | 102_A | 1.385 | 0.99 |
| 46_A | 121_V | 1.383 | 0.99 |
| 169_S | 304_A | 1.382 | 0.99 |
| 700_Q | 704_E | 1.380 | 0.99 |
| 553_Y | 557_R | 1.377 | 0.99 |
| 307_A | 311_K | 1.374 | 0.99 |
| 595_H | 600_K | 1.373 | 0.99 |
| 845_Q | 849_K | 1.371 | 0.99 |
| 21_A | 380_A | 1.371 | 0.99 |
| 593_V | 654_F | 1.368 | 0.99 |
| 595_H | 601_E | 1.363 | 0.99 |
| 602_K | 646_I | 1.363 | 0.99 |
| 327_D | 330_P | 1.363 | 0.99 |
| 201_D | 251_K | 1.361 | 0.99 |
| 171_V | 301_T | 1.356 | 0.99 |
| 12_W | 894_W | 1.356 | 0.99 |
| 251_K | 254_Q | 1.350 | 0.99 |
| 195_F | 259_V | 1.348 | 0.99 |
| 577_L | 589_V | 1.345 | 0.99 |
| 25_A | 383_A | 1.341 | 0.99 |
| 3_F | 10_F | 1.339 | 0.99 |
| 191_E | 194_K | 1.337 | 0.98 |
| 577_L | 586_T | 1.337 | 0.98 |
| 18_I | 377_G | 1.331 | 0.98 |
| 528_D | 532_G | 1.331 | 0.98 |
| 652_R | 655_S | 1.330 | 0.98 |
| 842_L | 846_L | 1.329 | 0.98 |
| 42_V | 106_V | 1.327 | 0.98 |
| 407_D | 939_K | 1.324 | 0.98 |
| 192_L | 202_V | 1.321 | 0.98 |
| 561_S | 921_T | 1.321 | 0.98 |
| 308_E | 312_M | 1.319 | 0.98 |
| 156_Y | 160_N | 1.318 | 0.98 |
| 52_D | 55_T | 1.313 | 0.98 |
| 590_L | 612_N | 1.313 | 0.98 |
| 201_D | 791_R | 1.312 | 0.98 |
| 911_A | 930_L | 1.310 | 0.98 |
| 949_K | 952_M | 1.308 | 0.98 |
| 42_V | 103_Q | 1.308 | 0.98 |
| 304_A | 308_E | 1.306 | 0.98 |
| 542_V | 546_I | 1.301 | 0.98 |
| 596_Y | 602_K | 1.300 | 0.98 |
| 415_V | 492_C | 1.299 | 0.98 |
| 5_I | 431_R | 1.298 | 0.98 |
| 191_E | 195_F | 1.297 | 0.98 |
| 605_V | 628_V | 1.297 | 0.98 |
| 552_A | 556_V | 1.295 | 0.98 |
| 370_A | 488_T | 1.292 | 0.98 |
| 144_T | 283_Q | 1.289 | 0.98 |
| 527_T | 965_D | 1.287 | 0.98 |
| 208_A | 736_Q | 1.286 | 0.98 |
| 596_Y | 656_Q | 1.285 | 0.98 |
| 249_L | 258_R | 1.284 | 0.98 |
| 162_K | 166_S | 1.284 | 0.98 |
| 644_E | 648_M | 1.277 | 0.98 |
| 141_V | 153_I | 1.276 | 0.98 |
| 541_L | 1027_V | 1.276 | 0.98 |
| 971_L | 975_L | 1.271 | 0.98 |
| 608_V | 626_A | 1.268 | 0.98 |
| 111_Q | 114_M | 1.262 | 0.98 |
| 750_G | 756_S | 1.262 | 0.98 |
| 130_K | 133_S | 1.261 | 0.98 |
| 791_R | 797_M | 1.260 | 0.98 |
| 57_Q | 817_R | 1.260 | 0.98 |
| 528_D | 531_G | 1.259 | 0.98 |
| 5_I | 490_A | 1.259 | 0.98 |
| 2_N | 435_G | 1.257 | 0.98 |
| 549_V | 552_A | 1.257 | 0.98 |
| 571_F | 650_A | 1.256 | 0.97 |
| 604_N | 631_K | 1.256 | 0.97 |
| 701_L | 826_I | 1.252 | 0.97 |
| 591_N | 594_T | 1.252 | 0.97 |
| 743_N | 747_T | 1.250 | 0.97 |
| 689_L | 854_V | 1.248 | 0.97 |
| 594_T | 600_K | 1.247 | 0.97 |
| 937_S | 1013_A | 1.246 | 0.97 |
| 62_Q | 817_R | 1.246 | 0.97 |
| 957_K | 961_E | 1.244 | 0.97 |
| 592_E | 659_D | 1.240 | 0.97 |
| 19_M | 373_V | 1.238 | 0.97 |
| 143_N | 147_T | 1.235 | 0.97 |
| 923_D | 926_F | 1.235 | 0.97 |
| 57_Q | 815_L | 1.232 | 0.97 |
| 589_V | 592_E | 1.230 | 0.97 |
| 418_V | 432_K | 1.230 | 0.97 |
| 986_M | 1007_M | 1.226 | 0.97 |
| 870_N | 873_P | 1.223 | 0.97 |
| 186_W | 266_K | 1.222 | 0.97 |
| 338_E | 999_Q | 1.222 | 0.97 |
| 586_T | 624_G | 1.222 | 0.97 |
| 139_V | 324_Y | 1.221 | 0.97 |
| 682_E | 823_S | 1.218 | 0.97 |
| 915_A | 926_F | 1.218 | 0.97 |
| 140_G | 285_A | 1.216 | 0.97 |
| 711_M | 828_G | 1.216 | 0.97 |
| 443_G | 886_C | 1.216 | 0.97 |
| 704_E | 846_L | 1.214 | 0.97 |
| 64_I | 110_L | 1.213 | 0.97 |
| 604_N | 641_N | 1.213 | 0.97 |
| 530_V | 534_L | 1.212 | 0.97 |
| 56_V | 87_V | 1.209 | 0.97 |
| 202_V | 264_V | 1.208 | 0.97 |
| 253_N | 257_S | 1.207 | 0.97 |
| 215_A | 235_A | 1.207 | 0.97 |
| 201_D | 204_T | 1.206 | 0.97 |
| 685_D | 688_G | 1.203 | 0.97 |
| 174_V | 288_L | 1.203 | 0.97 |
| 414_N | 947_F | 1.200 | 0.96 |
| 533_I | 1019_F | 1.199 | 0.96 |
| 311_K | 314_P | 1.195 | 0.96 |
| 514_W | 517_R | 1.194 | 0.96 |
| 316_F | 322_I | 1.193 | 0.96 |
| 575_V | 624_G | 1.192 | 0.96 |
| 423_G | 428_E | 1.192 | 0.96 |
| 606_E | 629_S | 1.188 | 0.96 |
| 303_A | 306_R | 1.186 | 0.96 |
| 612_N | 624_G | 1.183 | 0.96 |
| 76_Y | 819_N | 1.183 | 0.96 |
| 306_R | 310_A | 1.182 | 0.96 |
| 757_Y | 769_K | 1.181 | 0.96 |
| 697_A | 850_L | 1.180 | 0.96 |
| 648_M | 651_T | 1.178 | 0.96 |
| 959_L | 963_T | 1.175 | 0.96 |
| 846_L | 849_K | 1.173 | 0.96 |
| 549_V | 553_Y | 1.172 | 0.96 |
| 906_L | 1016_L | 1.170 | 0.96 |
| 414_N | 437_I | 1.169 | 0.96 |
| 114_M | 123_Q | 1.168 | 0.96 |
| 732_Q | 742_I | 1.168 | 0.96 |
| 44_I | 64_I | 1.167 | 0.96 |
| 260_L | 263_D | 1.167 | 0.96 |
| 588_K | 592_E | 1.163 | 0.96 |
| 592_E | 596_Y | 1.162 | 0.96 |
| 164_A | 312_M | 1.161 | 0.95 |
| 234_I | 725_Q | 1.160 | 0.95 |
| 726_F | 782_P | 1.159 | 0.95 |
| 815_L | 822_P | 1.159 | 0.95 |
| 217_Q | 230_N | 1.159 | 0.95 |
| 76_Y | 92_T | 1.158 | 0.95 |
| 818_Y | 859_T | 1.157 | 0.95 |
| 74_L | 77_M | 1.152 | 0.95 |
| 250_L | 259_V | 1.151 | 0.95 |
| 847_A | 856_Y | 1.150 | 0.95 |
| 653_A | 656_Q | 1.147 | 0.95 |
| 188_N | 778_Y | 1.147 | 0.95 |
| 15_A | 487_L | 1.146 | 0.95 |
| 137_M | 305_I | 1.145 | 0.95 |
| 792_A | 795_G | 1.145 | 0.95 |
| 760_D | 769_K | 1.143 | 0.95 |
| 432_K | 435_G | 1.141 | 0.95 |
| 114_M | 122_Q | 1.140 | 0.95 |
| 978_S | 1014_T | 1.140 | 0.95 |
| 950_D | 955_E | 1.136 | 0.95 |
| 710_D | 834_K | 1.135 | 0.95 |
| 162_K | 174_V | 1.134 | 0.95 |
| 45_S | 86_T | 1.131 | 0.95 |
| 600_K | 608_V | 1.128 | 0.94 |
| 142_I | 321_K | 1.126 | 0.94 |
| 261_L | 265_A | 1.126 | 0.94 |
| 126_V | 130_K | 1.126 | 0.94 |
| 821_L | 855_G | 1.125 | 0.94 |
| 128_V | 131_S | 1.122 | 0.94 |
| 246_G | 266_K | 1.122 | 0.94 |
| 109_K | 112_L | 1.120 | 0.94 |
| 571_F | 647_T | 1.120 | 0.94 |
| 381_V | 479_L | 1.119 | 0.94 |
| 558_L | 912_L | 1.118 | 0.94 |
| 19_M | 23_G | 1.118 | 0.94 |
| 544_Y | 1020_F | 1.117 | 0.94 |
| 961_E | 965_D | 1.116 | 0.94 |
| 249_L | 260_L | 1.116 | 0.94 |
| 525_H | 528_D | 1.113 | 0.94 |
| 373_V | 487_L | 1.112 | 0.94 |
| 965_D | 968_R | 1.112 | 0.94 |
| 67_N | 113_A | 1.112 | 0.94 |
| 948_A | 963_T | 1.111 | 0.94 |
| 792_A | 796_Q | 1.111 | 0.94 |
| 947_F | 969_M | 1.107 | 0.94 |
| 245_F | 770_V | 1.104 | 0.94 |
| 306_R | 329_T | 1.102 | 0.94 |
| 740_V | 745_I | 1.101 | 0.94 |
| 844_E | 848_S | 1.099 | 0.93 |
| 4_F | 11_A | 1.097 | 0.93 |
| 841_E | 845_Q | 1.094 | 0.93 |
| 725_Q | 811_G | 1.094 | 0.93 |
| 369_I | 491_L | 1.094 | 0.93 |
| 302_A | 329_T | 1.094 | 0.93 |
| 260_L | 733_E | 1.093 | 0.93 |
| 297_N | 300_D | 1.092 | 0.93 |
| 975_L | 979_L | 1.091 | 0.93 |
| 751_A | 756_S | 1.089 | 0.93 |
| 164_A | 315_F | 1.088 | 0.93 |
| 692_E | 695_T | 1.088 | 0.93 |
| 154_S | 158_A | 1.086 | 0.93 |
| 978_S | 982_I | 1.086 | 0.93 |
| 184_R | 773_M | 1.085 | 0.93 |
| 444_I | 481_V | 1.085 | 0.93 |
| 986_M | 990_I | 1.085 | 0.93 |
| 557_R | 916_T | 1.084 | 0.93 |
| 708_H | 846_L | 1.084 | 0.93 |
| 78_S | 92_T | 1.084 | 0.93 |
| 382_L | 387_F | 1.078 | 0.93 |
| 819_N | 857_D | 1.076 | 0.92 |
| 979_L | 983_L | 1.073 | 0.92 |
| 448_L | 939_K | 1.071 | 0.92 |
| 547_I | 909_I | 1.071 | 0.92 |
| 46_A | 64_I | 1.069 | 0.92 |
| 534_L | 963_T | 1.068 | 0.92 |
| 706_A | 715_V | 1.068 | 0.92 |
| 177_F | 289_G | 1.066 | 0.92 |
| 128_V | 133_S | 1.066 | 0.92 |
| 740_V | 793_A | 1.066 | 0.92 |
| 165_I | 174_V | 1.066 | 0.92 |
| 699_N | 703_A | 1.064 | 0.92 |
| 80_N | 90_T | 1.063 | 0.92 |
| 56_V | 81_S | 1.060 | 0.92 |
| 445_A | 481_V | 1.054 | 0.91 |
| 843_M | 858_W | 1.053 | 0.91 |
| 920_L | 1000_N | 1.052 | 0.91 |
| 539_R | 542_V | 1.050 | 0.91 |
| 545_L | 549_V | 1.049 | 0.91 |
| 780_M | 784_D | 1.048 | 0.91 |
| 414_N | 418_V | 1.047 | 0.91 |
| 678_G | 685_D | 1.047 | 0.91 |
| 139_V | 322_I | 1.046 | 0.91 |
| 206_I | 758_V | 1.044 | 0.91 |
| 669_A | 672_E | 1.044 | 0.91 |
| 698_R | 702_L | 1.043 | 0.91 |
| 773_M | 779_R | 1.042 | 0.91 |
| 693_K | 854_V | 1.040 | 0.91 |
| 784_D | 787_D | 1.037 | 0.91 |
| 641_N | 645_A | 1.035 | 0.90 |
| 182_A | 272_E | 1.033 | 0.90 |
| 785_I | 806_S | 1.031 | 0.90 |
| 982_I | 1010_M | 1.030 | 0.90 |
| 950_D | 954_K | 1.030 | 0.90 |
| 450_A | 882_V | 1.030 | 0.90 |
| 550_G | 554_L | 1.030 | 0.90 |
| 302_A | 306_R | 1.029 | 0.90 |
| 15_A | 373_V | 1.029 | 0.90 |
| 186_W | 775_E | 1.028 | 0.90 |
| 154_S | 179_S | 1.027 | 0.90 |
| 247_K | 733_E | 1.026 | 0.90 |
| 197_L | 250_L | 1.025 | 0.90 |
| 533_I | 1023_V | 1.024 | 0.90 |
| 307_A | 310_A | 1.023 | 0.90 |
| 877_A | 881_I | 1.021 | 0.90 |
| 948_A | 966_A | 1.021 | 0.90 |
| 914_A | 1004_T | 1.020 | 0.90 |
| 378_T | 475_S | 1.017 | 0.89 |
| 205_A | 248_I | 1.015 | 0.89 |
| 245_F | 267_I | 1.015 | 0.89 |
| 277_I | 587_Q | 1.015 | 0.89 |
| 202_V | 772_V | 1.015 | 0.89 |
| 597_Y | 626_A | 1.013 | 0.89 |
| 701_L | 846_L | 1.010 | 0.89 |
| 79_S | 817_R | 1.010 | 0.89 |
| 446_M | 886_C | 1.009 | 0.89 |
| 683_L | 701_L | 1.007 | 0.89 |
| 141_V | 322_I | 1.003 | 0.89 |
| 597_Y | 628_V | 1.003 | 0.89 |
| 527_T | 964_L | 1.000 | 0.88 |
| 10_F | 889_A | 1.000 | 0.88 |
| 246_G | 265_A | 1.000 | 0.88 |
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
- Text file of contact predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
- Import to GREMLIN BETA - features includes ability to upload PDB and latest P(contact) calculation based on eLife 2015 fitting to PDB data.
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | M | Cov | P(%) | HHΔ | |
| 4k0jA | 6 | 0.9302 | 100 | 0.244 | Contact Map |
| 3w9iA | 6 | 0.9942 | 100 | 0.284 | Contact Map |
| 4dx5A | 3 | 1 | 100 | 0.301 | Contact Map |
| 4mt1A | 1 | 0.9719 | 100 | 0.305 | Contact Map |
| 3ne5A | 1 | 0.9612 | 100 | 0.307 | Contact Map |
| 3aqpA | 2 | 0.6731 | 100 | 0.749 | Contact Map |
| 2ew9A | 1 | 0.1445 | 61.5 | 0.985 | Contact Map |
| 1p6tA | 1 | 0.1455 | 55.6 | 0.985 | Contact Map |
| 2l3mA | 1 | 0.0689 | 35.8 | 0.987 | Contact Map |
| 2ropA | 1 | 0.1329 | 31.7 | 0.987 | Contact Map |
Cov = coverage of hit
P(%) = probability
Sequence Conservation (Image Generated using WebLogo v3)