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OPENSEQ.org

unk

ID: 1403762044 Query Sequence

Download Alignment
We filter this alignment to remove positions that have > 50% gaps before running GREMLIN.
Length: 1272 (1220)
Sequences: 1511 (1244.5)
Seq/Len: 1.239
Nf(neff/√len): 35.6

Jackhmmer Results: (2014_04_16)
Sequences per length for each position, BEFORE the coverage/gap filter was applied

Legend: Dots above the red line, indicates positions where there is > 5 sequences per length (if visible, green bar = 20 seq/len). Point of this graphic is to give you an idea if resubmitting a sub-portion of your sequence might help increase the overall Seq/Len (which after applying the coverage filter is at: 1.239).

Sequences per length for each position, AFTER the coverage/gap filter was applied
Legend: If visible, the positions blocked in grey are regions that have > 50% gaps and were automatically trimmed and excluded in the GREMLIN analysis.

Trim query Generate MSA using: Filter MSA GREMLIN
Start: End: E-value: Iterations: Coverage: Remove gaps: Prior:

GREMLIN Results:
Residue pairs sorted by coevolution strength:

Legend: The darker and larger the blue dots, the higher strength in covariance. Below we provide the list of the top [1.5 x length] covarying residues with sequence seperation > 3. The i and j are positions as given in the input sequence.

ij Scaled score Prob
49_N62_G4.2721.00
610_V626_I3.8091.00
984_F993_L2.8851.00
840_V853_G2.8481.00
555_A577_V2.7751.00
769_G788_L2.6671.00
999_I1002_A2.5741.00
941_L966_L2.5711.00
1220_S1228_Q2.5401.00
962_N981_D2.3690.99
1145_I1156_A2.3640.99
459_N487_T2.3220.99
1098_R1116_E2.3170.99
1061_R1085_R2.2990.99
903_L917_G2.2860.99
1227_L1246_Y2.2200.99
963_G980_P2.1450.98
996_R1044_A2.1430.98
853_G885_L2.1140.98
1234_G1237_D2.0850.98
1116_E1133_K2.0830.98
1062_L1081_V2.0760.98
1152_T1155_E2.0710.98
824_L840_V2.0550.98
719_C728_C2.0550.98
1077_L1108_V2.0500.98
323_K329_L1.9950.97
727_L745_L1.9870.97
75_G100_D1.9780.97
698_L701_A1.9770.97
838_G855_V1.9660.97
888_N892_P1.9450.96
458_W488_G1.8940.96
1202_S1221_G1.8880.95
1093_Q1119_R1.8600.95
856_D882_Q1.8580.95
1088_F1141_P1.8530.95
826_W838_G1.8460.95
887_G892_P1.8460.95
1151_K1155_E1.8330.94
29_Q32_L1.8250.94
994_D1040_Q1.8110.94
101_V141_T1.8060.94
1068_V1077_L1.7750.93
982_L995_G1.7630.93
743_I771_A1.7420.92
1089_K1094_D1.7170.91
900_I903_L1.7080.91
1179_M1183_L1.7030.91
979_N1000_P1.7010.91
1007_Q1010_P1.6960.91
138_L141_T1.6940.91
1042_N1067_K1.6910.91
233_Q237_I1.6900.91
1263_A1270_F1.6870.91
1252_L1266_L1.6860.90
992_K1040_Q1.6850.90
1249_M1252_L1.6760.90
994_D1042_N1.6660.90
103_V143_V1.6590.90
1019_D1022_M1.6550.89
902_Q916_K1.6520.89
1110_Q1137_L1.6440.89
1002_A1051_V1.6440.89
1095_L1245_R1.6420.89
469_T478_A1.6400.89
1064_G1106_G1.6400.89
1222_K1225_D1.6400.89
958_V983_V1.6390.89
98_T101_V1.6380.89
612_G624_L1.6060.87
840_V852_S1.6050.87
28_T31_G1.6040.87
643_L656_L1.5870.87
1110_Q1139_D1.5860.87
1019_D1023_L1.5740.86
1097_V1115_I1.5610.85
729_V743_I1.5510.85
497_L501_E1.5500.85
1151_K1154_Q1.5210.83
1268_Y1272_F1.5210.83
458_W486_T1.5200.83
1018_S1022_M1.5180.83
1060_A1083_I1.5070.82
806_I809_D1.5060.82
838_G853_G1.4960.82
1131_G1146_F1.4930.82
998_D1046_N1.4900.81
1095_L1131_G1.4880.81
573_I594_A1.4870.81
417_A421_L1.4800.81
980_P997_I1.4790.81
1095_L1119_R1.4690.80
183_T187_G1.4680.80
34_F38_S1.4650.80
401_Y425_G1.4540.79
118_P121_P1.4360.78
936_T966_L1.4340.78
739_G775_W1.4290.78
1047_I1064_G1.4280.78
765_G771_A1.4260.77
876_Q904_K1.4260.77
1099_K1114_N1.4240.77
559_A562_L1.4230.77
687_T720_W1.4190.77
1046_N1065_A1.4160.77
1057_G1092_G1.4150.77
257_G260_P1.4130.76
591_D611_K1.4130.76
883_L894_L1.4090.76
1245_R1255_Q1.4080.76
784_A817_I1.4060.76
654_L671_G1.4060.76
624_L645_A1.4030.76
814_N825_Q1.4000.76
750_L765_G1.4000.76
470_A478_A1.3980.75
1020_E1023_L1.3930.75
857_I881_A1.3890.75
1088_F1119_R1.3860.75
1121_P1159_Y1.3840.74
960_A983_V1.3820.74
460_A488_G1.3790.74
1019_D1119_R1.3730.74
640_Q658_M1.3710.73
327_A343_L1.3710.73
316_M323_K1.3690.73
1222_K1228_Q1.3680.73
1231_Y1265_D1.3640.73
696_W725_A1.3640.73
652_H680_W1.3610.73
448_G460_A1.3590.72
321_E329_L1.3570.72
1098_R1118_I1.3560.72
927_T946_N1.3380.71
696_W722_N1.3350.71
1048_G1061_R1.3320.70
980_P1232_G1.3290.70
899_G920_D1.3250.70
448_G459_N1.3250.70
936_T1119_R1.3180.69
1222_K1226_D1.3170.69
325_Q329_L1.3140.69
749_D752_M1.3120.69
980_P1236_F1.3070.68
745_L769_G1.3050.68
996_R1046_N1.3050.68
1119_R1131_G1.3020.68
936_T974_V1.3000.68
161_W164_R1.3000.68
1228_Q1247_R1.2990.67
1119_R1259_G1.2940.67
1015_S1018_S1.2930.67
1229_V1244_L1.2900.67
914_I934_I1.2900.67
1257_V1263_A1.2890.67
1104_F1111_P1.2890.67
904_K913_D1.2880.67
1081_V1097_V1.2880.67
1070_Q1075_L1.2840.66
1064_G1090_A1.2810.66
462_L484_I1.2790.66
1108_V1119_R1.2790.66
119_S122_L1.2780.66
1104_F1163_G1.2760.65
628_A641_L1.2720.65
423_A430_I1.2700.65
764_R794_G1.2690.65
1019_D1131_G1.2680.65
466_G479_K1.2650.64
439_A442_G1.2650.64
220_D224_T1.2650.64
85_C92_C1.2650.64
372_S390_T1.2600.64
1062_L1095_L1.2600.64
749_D766_V1.2600.64
647_G652_H1.2580.64
1245_R1268_Y1.2570.64
719_C980_P1.2570.64
824_L838_G1.2550.64
102_I142_R1.2530.63
1135_T1144_E1.2500.63
458_W490_L1.2500.63
980_P999_I1.2490.63
926_A948_D1.2490.63
790_G793_V1.2490.63
1057_G1095_L1.2470.63
1001_W1050_D1.2450.63
1230_K1255_Q1.2450.63
936_T1111_P1.2430.62
881_A973_M1.2420.62
786_V815_A1.2400.62
416_P439_A1.2390.62
911_P1110_Q1.2350.62
945_G959_V1.2350.62
99_R139_A1.2330.62
76_E99_R1.2330.62
1263_A1268_Y1.2320.61
915_T1244_L1.2320.61
575_G592_I1.2320.61
652_H682_G1.2320.61
506_G513_I1.2310.61
1233_M1236_F1.2300.61
680_W1090_A1.2290.61
1138_A1186_G1.2270.61
594_A608_V1.2270.61
392_L405_L1.2260.61
941_L1221_G1.2250.61
1093_Q1160_L1.2250.61
728_C980_P1.2240.61
513_I543_I1.2220.61
316_M329_L1.2210.60
1232_G1243_T1.2200.60
1223_I1227_L1.2190.60
606_G630_Q1.2190.60
1062_L1119_R1.2190.60
1227_L1244_L1.2180.60
536_L545_G1.2170.60
64_E73_N1.2170.60
1017_S1021_V1.2170.60
1100_G1117_A1.2150.60
970_L1101_Q1.2090.59
503_T506_G1.2070.59
519_A610_V1.2050.59
432_L448_G1.2050.59
1217_V1232_G1.2040.59
1216_Q1232_G1.2020.59
1181_I1184_G1.1990.58
1088_F1130_A1.1980.58
60_L63_V1.1970.58
1098_R1129_I1.1970.58
854_T884_R1.1960.58
993_L1043_L1.1960.58
648_T652_H1.1950.58
539_N559_A1.1900.57
1134_V1137_L1.1900.57
1098_R1148_E1.1880.57
1156_A1233_M1.1870.57
1186_G1227_L1.1870.57
1113_L1141_P1.1850.57
854_T882_Q1.1850.57
873_E907_G1.1830.57
967_R970_L1.1830.57
594_A630_Q1.1820.57
1052_T1061_R1.1820.57
430_I450_A1.1820.57
1185_V1231_Y1.1820.57
532_L547_L1.1820.57
1119_R1159_Y1.1790.56
1232_G1236_F1.1770.56
1255_Q1267_L1.1770.56
1101_Q1114_N1.1770.56
1129_I1148_E1.1760.56
1057_G1062_L1.1750.56
834_G840_V1.1750.56
1230_K1243_T1.1740.56
928_S949_W1.1730.56
434_R447_T1.1720.56
745_L748_F1.1720.56
1044_A1067_K1.1700.56
581_G586_P1.1700.56
980_P1159_Y1.1690.55
719_C963_G1.1690.55
1247_R1255_Q1.1690.55
973_M1062_L1.1680.55
965_K1000_P1.1680.55
652_H671_G1.1670.55
1064_G1081_V1.1660.55
120_E123_T1.1660.55
536_L539_N1.1660.55
1161_L1180_L1.1650.55
1016_A1019_D1.1650.55
442_G467_I1.1640.55
1056_F1062_L1.1610.55
680_W1091_Y1.1610.55
1230_K1233_M1.1600.55
1132_V1223_I1.1580.54
631_L638_I1.1570.54
1095_L1259_G1.1560.54
809_D815_A1.1550.54
669_L1254_L1.1530.54
1095_L1188_S1.1530.54
1036_S1049_D1.1520.54
997_I1045_I1.1490.54
327_A333_G1.1490.54
464_I467_I1.1480.53
26_L31_G1.1460.53
652_H1095_L1.1450.53
607_S629_R1.1450.53
775_W779_G1.1440.53
1252_L1255_Q1.1410.53
1093_Q1106_G1.1400.53
340_K343_L1.1390.53
1184_G1255_Q1.1390.53
417_A423_A1.1390.53
775_W782_P1.1370.52
974_V1156_A1.1370.52
911_P1221_G1.1360.52
1055_A1088_F1.1350.52
1054_D1059_K1.1350.52
1201_I1204_L1.1340.52
90_Q130_P1.1320.52
980_P1146_F1.1310.52
1091_Y1119_R1.1310.52
1118_I1129_I1.1310.52
545_G581_G1.1300.52
838_G842_V1.1280.51
589_I613_D1.1280.51
1064_G1111_P1.1270.51
881_A1070_Q1.1250.51
696_W968_V1.1250.51
866_K875_A1.1240.51
1047_I1061_R1.1230.51
976_I1143_V1.1230.51
559_A569_L1.1220.51
442_G488_G1.1220.51
1141_P1153_Q1.1220.51
372_S375_V1.1210.51
963_G1236_F1.1210.51
1157_L1162_R1.1210.51
995_G999_I1.1180.50
825_Q839_H1.1180.50
1159_Y1165_G1.1170.50
968_V1174_A1.1160.50
748_F1058_L1.1150.50
532_L548_G1.1140.50
1016_A1020_E1.1140.50
124_E127_A1.1130.50
237_I246_E1.1110.50
150_L178_V1.1110.50
1260_M1263_A1.1100.50
419_L437_L1.1100.50
270_A277_V1.1100.50
968_V1115_I1.1090.50
1155_E1205_A1.1090.50
558_N561_G1.1080.49
1091_Y1159_Y1.1080.49
341_L355_A1.1080.49
1090_A1095_L1.1070.49
1230_K1265_D1.1060.49
1112_Y1137_L1.1060.49
165_Q175_D1.1060.49
811_V828_I1.1040.49
1114_N1226_D1.1030.49
834_G1131_G1.1030.49
416_P423_A1.1030.49
1257_V1262_Q1.1010.49
1234_G1239_L1.1010.49
1093_Q1145_I1.1000.49
28_T32_L1.1000.49
175_D178_V1.1000.49
1064_G1128_V1.0990.49
243_I246_E1.0970.48
184_P187_G1.0970.48
1263_A1267_L1.0940.48
1108_V1257_V1.0940.48
497_L536_L1.0930.48
1126_D1255_Q1.0910.48
1055_A1143_V1.0910.48
1010_P1022_M1.0910.48
1095_L1146_F1.0900.48
323_K327_A1.0900.48
1108_V1111_P1.0900.48
1106_G1117_A1.0900.48
862_L1064_G1.0900.48
1115_I1221_G1.0890.48
922_R931_S1.0880.48
232_A235_P1.0870.47
1057_G1188_S1.0860.47
32_L44_P1.0860.47
415_P425_G1.0850.47
1141_P1161_L1.0850.47
234_L237_I1.0840.47
986_A1265_D1.0840.47
654_L851_L1.0830.47
990_L1038_P1.0820.47
906_V913_D1.0820.47
435_L446_I1.0810.47
739_G971_P1.0810.47
229_P252_Q1.0810.47
671_G682_G1.0800.47
768_T791_Q1.0790.47
897_Q920_D1.0780.47
1192_V1246_Y1.0780.47
447_T461_L1.0780.47
592_I610_V1.0780.47
1252_L1259_G1.0770.46
1220_S1272_F1.0760.46
1230_K1234_G1.0760.46
1231_Y1236_F1.0760.46
1215_S1225_D1.0760.46
558_N574_K1.0760.46
561_G567_P1.0750.46
1092_G1159_Y1.0740.46
372_S378_P1.0740.46
1206_L1221_G1.0730.46
949_W1253_Y1.0730.46
1145_I1158_S1.0730.46
49_N63_V1.0730.46
924_N927_T1.0730.46
1223_I1246_Y1.0720.46
696_W971_P1.0710.46
1257_V1260_M1.0710.46
809_D813_L1.0690.46
506_G1095_L1.0680.46
1098_R1220_S1.0670.45
1132_V1159_Y1.0670.45
1092_G1119_R1.0660.45
1247_R1253_Y1.0660.45
232_A236_E1.0660.45
74_V77_L1.0660.45
744_T770_D1.0650.45
326_Q334_A1.0650.45
1183_L1204_L1.0650.45
590_A1023_L1.0630.45
1111_P1127_N1.0630.45
27_G32_L1.0630.45
784_A1130_A1.0630.45
979_N998_D1.0630.45
1093_Q1158_S1.0620.45
719_C1236_F1.0600.45
1056_F1184_G1.0600.45
991_L1039_I1.0590.45
958_V985_E1.0590.45
545_G577_V1.0580.45
320_E329_L1.0580.45
1178_A1222_K1.0570.44
767_F790_G1.0570.44
1178_A1186_G1.0570.44
1217_V1248_L1.0570.44
239_I251_K1.0560.44
1056_F1188_S1.0560.44
869_L872_G1.0550.44
1113_L1134_V1.0540.44
1159_Y1255_Q1.0540.44
1048_G1131_G1.0540.44
215_E218_L1.0540.44
1254_L1258_S1.0540.44
647_G680_W1.0530.44
897_Q922_R1.0530.44
853_G1131_G1.0530.44
936_T1108_V1.0530.44
444_A464_I1.0520.44
290_K293_L1.0510.44
957_A986_A1.0510.44
907_G961_A1.0510.44
967_R975_R1.0500.44
46_L65_Y1.0490.44
1120_N1129_I1.0480.44
1010_P1019_D1.0480.44
1247_R1269_Q1.0470.44
1099_K1116_E1.0460.43
747_R768_T1.0460.43
1267_L1270_F1.0460.43
978_V1134_V1.0460.43
1252_L1257_V1.0460.43
813_L826_W1.0450.43
487_T497_L1.0450.43
533_T542_D1.0440.43
959_V1191_L1.0440.43
1164_E1234_G1.0440.43
48_I169_K1.0430.43
580_R684_L1.0420.43
152_L173_I1.0410.43
1090_A1093_Q1.0410.43
1127_N1162_R1.0410.43
539_N652_H1.0400.43
1118_I1146_F1.0400.43
1056_F1255_Q1.0390.43
1146_F1159_Y1.0390.43
1263_A1272_F1.0390.43
52_N59_R1.0380.43
412_Q415_P1.0380.43
886_G895_F1.0370.43
825_Q840_V1.0370.43
630_Q639_R1.0350.42
1265_D1270_F1.0340.42
1102_I1115_I1.0340.42
463_T483_R1.0340.42
1246_Y1265_D1.0330.42
731_K775_W1.0330.42
911_P970_L1.0330.42
936_T1062_L1.0330.42
228_K231_L1.0330.42
1227_L1250_P1.0320.42
1090_A1119_R1.0320.42
852_S885_L1.0320.42
986_A1056_F1.0320.42
1190_Q1193_G1.0310.42
980_P1000_P1.0310.42
295_G306_N1.0310.42
797_Q1095_L1.0300.42
826_W840_V1.0300.42
857_I882_Q1.0290.42
726_Q746_T1.0290.42
860_L1083_I1.0280.42
1191_L1198_T1.0270.42
1106_G1128_V1.0270.42
1006_V1055_A1.0260.42
1221_G1231_Y1.0250.41
25_I28_T1.0250.41
769_G1178_A1.0240.41
1130_A1160_L1.0240.41
82_N94_E1.0240.41
1248_L1251_R1.0220.41
1047_I1050_D1.0220.41
971_P1006_V1.0220.41
834_G838_G1.0210.41
446_I460_A1.0210.41
54_G59_R1.0210.41
1198_T1202_S1.0200.41
1119_R1157_L1.0180.41
355_A367_K1.0180.41
295_G298_T1.0180.41
561_G565_L1.0180.41
825_Q828_I1.0180.41
100_D140_N1.0180.41
594_A597_I1.0170.41
277_V282_L1.0160.41
1247_R1252_L1.0160.41
923_F1235_I1.0160.41
1091_Y1265_D1.0150.40
355_A368_L1.0150.40
269_Q281_R1.0150.40
974_V1077_L1.0150.40
765_G792_G1.0150.40
241_V245_V1.0150.40
1091_Y1131_G1.0140.40
1243_T1255_Q1.0140.40
131_I138_L1.0140.40
883_L896_G1.0130.40
857_I860_L1.0120.40
928_S1253_Y1.0120.40
416_P421_L1.0120.40
963_G1000_P1.0110.40
921_I1225_D1.0100.40
107_T145_I1.0100.40
768_T771_A1.0090.40
215_E220_D1.0090.40
720_W911_P1.0090.40
1156_A1243_T1.0070.40
1095_L1258_S1.0070.40
788_L935_E1.0060.40
717_S730_P1.0060.40
1019_D1234_G1.0050.40
25_I29_Q1.0050.40
437_L592_I1.0050.40
907_G930_L1.0050.40
715_I718_H1.0050.40
570_A598_K1.0050.40
1246_Y1256_A1.0040.39
1216_Q1243_T1.0040.39
1155_E1159_Y1.0040.39
1212_G1235_I1.0040.39
1160_L1208_T1.0040.39
260_P263_I1.0030.39
331_L370_L1.0030.39
626_I677_K1.0020.39
230_L233_Q1.0020.39
971_P1243_T1.0020.39
1133_K1144_E1.0010.39
1215_S1218_V1.0010.39
761_T1088_F1.0000.39
1231_Y1234_G1.0000.39
636_L806_I1.0000.39
Legend: Only predictions with Scaled Score > 1 are listed. For all 3L/2 predictions, click on one of the links below.
Prob = P(contact | scaled_score, seq/len).
Scaled Score = (raw_score/average(raw_scores)).
NEW Features
HHsearch Results: (21Jun14)
GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled Score > 1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-position alignment confidence. Inter oligomeric contacts in the pdb are in shades of red.
PDB M Cov P(%) HHΔ  
3lycA160.177746.90.983Contact Map
4c69X10.183244.90.983Contact Map
3petA20.157231.90.984Contact Map
3jx8A60.182428.20.985Contact Map
3hpeA20.116419.10.986Contact Map
4opwA20.179213.70.987Contact Map
1m56D20.018112.50.987Contact Map
1qleD10.018111.30.987Contact Map
1oo0A10.03777.80.988Contact Map
4bbjA10.04727.20.988Contact Map
M = number of chains, if homo-oligomer
Cov = coverage of hit
P(%) = probability

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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