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OPENSEQ.org
TAUA - Taurine-binding periplasmic protein
UniProt: Q47537 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13300
Length: 320 (291)
Sequences: 4730
Seq/Len: 16.25
TAUA
Paralog alert: 0.60 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: SSUA TAUA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
47_K 230_D 4.006 1.00
48_E 226_K 3.975 1.00
238_N 247_E 3.773 1.00
124_R 152_E 3.715 1.00
234_P 238_N 3.627 1.00
94_E 211_K 3.438 1.00
121_I 150_Q 3.354 1.00
212_D 216_K 3.346 1.00
250_S 260_E 3.25 1.00
48_E 230_D 3.245 1.00
309_D 312_Q 3.186 1.00
92_P 211_K 3.029 1.00
116_K 119_D 2.931 1.00
222_K 226_K 2.917 1.00
126_A 170_I 2.856 1.00
211_K 215_E 2.849 1.00
213_F 217_H 2.806 1.00
291_I 295_Q 2.805 1.00
24_N 52_T 2.798 1.00
240_D 264_P 2.687 1.00
24_N 54_D 2.677 1.00
45_F 228_A 2.665 1.00
28_A 73_V 2.633 1.00
115_S 119_D 2.544 1.00
26_T 54_D 2.521 1.00
42_D 247_E 2.412 1.00
146_I 150_Q 2.402 1.00
147_K 150_Q 2.389 1.00
44_T 230_D 2.388 1.00
41_A 254_R 2.242 1.00
219_E 223_A 2.191 1.00
295_Q 299_E 2.146 1.00
209_V 214_A 2.145 1.00
233_Q 237_A 2.101 1.00
75_I 209_V 1.985 1.00
177_A 181_N 1.98 1.00
115_S 188_K 1.962 1.00
44_T 227_S 1.923 1.00
118_E 121_I 1.834 1.00
250_S 254_R 1.826 1.00
217_H 220_V 1.825 1.00
209_V 221_V 1.812 1.00
123_K 171_D 1.809 1.00
134_H 138_L 1.797 1.00
247_E 250_S 1.769 1.00
156_L 164_A 1.741 1.00
120_L 172_G 1.722 1.00
44_T 47_K 1.714 1.00
260_E 264_P 1.699 1.00
234_P 247_E 1.697 1.00
259_P 262_D 1.693 1.00
298_K 307_A 1.685 1.00
75_I 221_V 1.674 1.00
124_R 154_V 1.657 1.00
118_E 144_W 1.656 1.00
142_K 299_E 1.656 1.00
141_L 151_V 1.623 1.00
44_T 234_P 1.623 1.00
75_I 224_F 1.599 1.00
125_I 172_G 1.546 1.00
213_F 220_V 1.521 1.00
218_P 222_K 1.514 1.00
113_T 188_K 1.495 1.00
223_A 227_S 1.493 1.00
235_Y 248_N 1.492 1.00
42_D 234_P 1.49 1.00
249_I 264_P 1.471 1.00
97_L 225_A 1.456 1.00
192_D 195_Q 1.434 1.00
213_F 221_V 1.433 1.00
40_Q 46_A 1.422 1.00
94_E 315_T 1.415 1.00
117_P 144_W 1.414 1.00
48_E 223_A 1.402 0.99
87_A 211_K 1.401 0.99
214_A 221_V 1.4 0.99
264_P 268_K 1.394 0.99
229_I 233_Q 1.382 0.99
253_A 260_E 1.355 0.99
141_L 146_I 1.351 0.99
39_A 45_F 1.327 0.99
110_V 188_K 1.318 0.99
184_E 265_G 1.31 0.99
43_N 46_A 1.296 0.99
261_G 264_P 1.293 0.99
117_P 140_A 1.283 0.99
71_G 212_D 1.253 0.99
265_G 268_K 1.251 0.99
38_V 42_D 1.249 0.99
210_R 213_F 1.247 0.99
124_R 171_D 1.246 0.98
295_Q 307_A 1.243 0.98
137_L 153_I 1.241 0.98
61_G 82_P 1.23 0.98
112_K 188_K 1.221 0.98
249_I 260_E 1.218 0.98
296_F 300_Q 1.215 0.98
316_S 320_Q 1.214 0.98
214_A 318_F 1.199 0.98
96_F 221_V 1.195 0.98
247_E 251_K 1.182 0.98
94_E 214_A 1.182 0.98
96_F 225_A 1.173 0.98
96_F 209_V 1.172 0.98
95_V 206_V 1.172 0.98
48_E 227_S 1.172 0.98
39_A 231_A 1.165 0.97
26_T 74_Q 1.164 0.97
35_P 232_Q 1.161 0.97
288_K 292_D 1.159 0.97
108_L 120_L 1.157 0.97
69_A 91_V 1.156 0.97
121_I 146_I 1.153 0.97
139_A 142_K 1.144 0.97
218_P 221_V 1.136 0.97
125_I 151_V 1.134 0.97
26_T 56_R 1.125 0.97
157_Q 160_A 1.125 0.97
51_A 223_A 1.121 0.97
41_A 255_L 1.119 0.96
63_S 66_R 1.116 0.96
58_F 67_A 1.111 0.96
107_A 180_V 1.109 0.96
213_F 218_P 1.108 0.96
28_A 58_F 1.101 0.96
219_E 222_K 1.1 0.96
111_K 168_G 1.094 0.96
68_L 73_V 1.092 0.96
68_L 76_G 1.091 0.96
38_V 234_P 1.082 0.96
287_N 311_S 1.079 0.95
75_I 96_F 1.061 0.95
44_T 48_E 1.059 0.95
25_V 213_F 1.053 0.95
211_K 214_A 1.048 0.94
185_K 261_G 1.032 0.94
185_K 265_G 1.028 0.94
170_I 173_A 1.022 0.93
64_I 76_G 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2x26A20.88751000.349Contact Map0.748
3qslA20.95631000.36Contact Map0.732
3ix1A20.89691000.376Contact Map0.73
2de3A20.91871000.378Contact Map0.629
2g29A10.93751000.379Contact Map0.744
3un6A10.93131000.382Contact Map0.561
4eswA20.89061000.395Contact Map0.709
2x7qA10.90311000.402Contact Map0.676
2i49A10.94061000.41Contact Map0.68
3uifA10.90941000.426Contact Map0.676
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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