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FHIA - Putative protein FhiA
UniProt: Q47153 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13144
Length: 579 (572)
Sequences: 932
Seq/Len: 1.63
FHIA
Paralog alert: 0.43 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: FHIA FLHA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
423_A 455_A 4.535 1.00
111_S 114_A 4.24 1.00
173_T 198_G 3.724 1.00
57_Q 60_T 3.633 1.00
97_L 120_V 3.384 1.00
90_M 94_A 3.291 1.00
170_Y 201_G 2.985 1.00
307_K 310_E 2.953 1.00
309_D 376_I 2.944 1.00
173_T 194_S 2.796 1.00
102_C 106_F 2.782 1.00
386_N 389_D 2.728 1.00
177_F 194_S 2.694 1.00
433_D 436_T 2.692 1.00
336_N 343_P 2.68 1.00
110_L 118_Q 2.547 1.00
105_I 112_A 2.316 1.00
436_T 440_V 2.27 0.99
94_A 98_I 2.248 0.99
441_L 454_L 2.234 0.99
199_F 203_R 2.228 0.99
394_H 438_A 2.226 0.99
537_L 558_L 2.203 0.99
247_S 291_N 2.174 0.99
25_I 146_T 2.151 0.99
110_L 114_A 2.066 0.99
430_S 465_S 2.023 0.98
299_Y 372_H 2.017 0.98
489_L 543_L 2.012 0.98
411_A 445_S 1.974 0.98
380_Y 383_D 1.97 0.98
412_L 441_L 1.956 0.98
548_A 552_R 1.955 0.98
54_N 57_Q 1.934 0.98
317_K 348_Q 1.917 0.98
314_P 333_V 1.904 0.98
170_Y 198_G 1.886 0.97
187_H 191_L 1.886 0.97
467_T 567_P 1.885 0.97
298_Q 310_E 1.791 0.96
521_M 551_A 1.754 0.95
25_I 141_A 1.749 0.95
320_A 347_I 1.724 0.95
123_T 127_G 1.719 0.95
421_Y 431_L 1.712 0.95
551_A 558_L 1.654 0.93
397_L 438_A 1.649 0.93
180_A 187_H 1.64 0.93
313_I 369_I 1.624 0.92
385_F 390_I 1.623 0.92
101_V 112_A 1.612 0.92
383_D 464_R 1.601 0.92
198_G 202_W 1.593 0.91
114_A 117_Q 1.554 0.90
89_G 126_D 1.547 0.90
56_A 59_Q 1.544 0.90
295_K 298_Q 1.544 0.90
412_L 417_L 1.529 0.89
364_D 367_S 1.518 0.89
18_V 134_S 1.515 0.88
12_T 91_M 1.51 0.88
183_P 190_F 1.507 0.88
323_S 361_Q 1.498 0.88
440_V 444_S 1.487 0.87
98_I 102_C 1.47 0.86
7_L 409_S 1.467 0.86
318_L 349_A 1.444 0.85
271_V 370_A 1.44 0.85
25_I 83_R 1.439 0.85
20_K 23_E 1.435 0.84
393_L 434_I 1.432 0.84
113_D 116_F 1.42 0.84
195_A 199_F 1.418 0.84
301_I 373_V 1.416 0.83
541_P 564_N 1.414 0.83
334_Q 345_T 1.397 0.82
319_M 335_G 1.39 0.82
16_I 89_G 1.383 0.81
267_R 305_G 1.379 0.81
287_R 302_F 1.375 0.81
409_S 417_L 1.375 0.81
430_S 469_P 1.37 0.81
183_P 186_P 1.361 0.80
304_N 433_D 1.353 0.79
83_R 141_A 1.351 0.79
303_I 308_A 1.35 0.79
537_L 547_L 1.349 0.79
198_G 394_H 1.333 0.78
246_L 413_N 1.322 0.77
257_D 260_Q 1.32 0.77
347_I 355_A 1.308 0.76
185_M 189_P 1.307 0.76
137_L 276_S 1.303 0.76
385_F 421_Y 1.293 0.75
417_L 441_L 1.286 0.74
387_Y 418_L 1.278 0.74
314_P 317_K 1.278 0.74
60_T 64_D 1.278 0.74
444_S 454_L 1.257 0.72
489_L 547_L 1.256 0.72
191_L 195_A 1.253 0.72
321_L 337_D 1.245 0.71
165_S 168_V 1.244 0.71
551_A 560_V 1.24 0.70
142_A 387_Y 1.234 0.70
37_M 65_V 1.231 0.70
433_D 465_S 1.23 0.70
412_L 416_Q 1.219 0.69
246_L 369_I 1.217 0.68
83_R 86_A 1.214 0.68
216_K 219_E 1.214 0.68
33_T 36_A 1.214 0.68
185_M 190_F 1.214 0.68
110_L 119_Y 1.213 0.68
338_P 371_T 1.201 0.67
86_A 134_S 1.197 0.67
45_D 86_A 1.194 0.66
14_N 409_S 1.19 0.66
74_A 106_F 1.187 0.66
382_P 426_T 1.178 0.65
53_I 61_R 1.178 0.65
273_Q 374_N 1.178 0.65
55_Q 276_S 1.176 0.65
14_N 416_Q 1.176 0.65
175_I 193_F 1.175 0.64
119_Y 256_V 1.172 0.64
330_I 345_T 1.171 0.64
275_I 429_V 1.168 0.64
116_F 521_M 1.167 0.64
137_L 142_A 1.164 0.63
124_I 185_M 1.162 0.63
65_V 69_A 1.162 0.63
101_V 105_I 1.158 0.63
18_V 139_T 1.157 0.63
16_I 83_R 1.153 0.62
196_L 199_F 1.153 0.62
194_S 198_G 1.152 0.62
33_T 244_I 1.152 0.62
38_P 41_Q 1.149 0.62
180_A 184_G 1.148 0.62
342_M 361_Q 1.147 0.62
105_I 109_N 1.147 0.62
83_R 316_D 1.145 0.61
170_Y 205_S 1.141 0.61
13_I 107_K 1.14 0.61
20_K 141_A 1.137 0.61
394_H 414_Y 1.127 0.60
98_I 111_S 1.126 0.60
113_D 523_Q 1.126 0.60
36_A 364_D 1.125 0.59
174_G 201_G 1.122 0.59
47_D 86_A 1.121 0.59
97_L 101_V 1.12 0.59
521_M 537_L 1.12 0.59
244_I 301_I 1.12 0.59
260_Q 326_T 1.12 0.59
490_T 542_Q 1.114 0.58
248_L 287_R 1.113 0.58
256_V 476_L 1.111 0.58
62_R 88_A 1.107 0.58
139_T 143_I 1.107 0.58
103_I 107_K 1.106 0.58
250_Y 296_P 1.106 0.58
99_G 124_I 1.104 0.57
72_Y 153_D 1.098 0.57
561_L 572_L 1.096 0.56
72_Y 139_T 1.094 0.56
119_Y 123_T 1.093 0.56
391_T 409_S 1.092 0.56
268_I 367_S 1.089 0.56
405_A 438_A 1.088 0.56
201_G 498_Q 1.087 0.56
351_Q 569_E 1.082 0.55
407_D 442_V 1.081 0.55
404_L 435_V 1.079 0.55
541_P 562_S 1.078 0.55
106_F 116_F 1.077 0.54
383_D 493_V 1.077 0.54
120_V 543_L 1.076 0.54
170_Y 173_T 1.074 0.54
84_G 131_Q 1.073 0.54
524_V 527_Q 1.072 0.54
114_A 118_Q 1.071 0.54
351_Q 354_K 1.07 0.54
138_S 432_R 1.069 0.54
21_G 24_R 1.068 0.54
65_V 101_V 1.068 0.54
8_L 94_A 1.065 0.53
177_F 210_A 1.064 0.53
194_S 202_W 1.064 0.53
449_K 551_A 1.063 0.53
54_N 60_T 1.063 0.53
167_S 196_L 1.062 0.53
538_L 556_P 1.061 0.53
110_L 406_E 1.06 0.53
547_L 552_R 1.059 0.53
20_K 89_G 1.057 0.52
120_V 407_D 1.057 0.52
363_I 371_T 1.056 0.52
434_I 438_A 1.055 0.52
108_Y 124_I 1.054 0.52
22_A 119_Y 1.048 0.51
15_F 172_A 1.046 0.51
525_K 537_L 1.041 0.51
279_N 381_I 1.04 0.51
188_L 203_R 1.039 0.50
124_I 402_P 1.035 0.50
429_V 470_F 1.034 0.50
26_S 388_D 1.034 0.50
304_N 436_T 1.032 0.50
315_A 430_S 1.031 0.50
268_I 373_V 1.031 0.50
252_L 288_I 1.029 0.49
244_I 377_V 1.029 0.49
66_A 70_D 1.027 0.49
384_L 425_L 1.026 0.49
113_D 210_A 1.025 0.49
56_A 111_S 1.025 0.49
300_A 310_E 1.023 0.49
436_T 465_S 1.022 0.49
142_A 276_S 1.019 0.48
146_T 388_D 1.019 0.48
144_I 149_S 1.017 0.48
324_S 342_M 1.015 0.48
14_N 398_S 1.015 0.48
398_S 406_E 1.013 0.48
88_A 122_M 1.013 0.48
340_Y 371_T 1.012 0.48
440_V 460_L 1.012 0.48
380_Y 539_V 1.009 0.47
155_A 386_N 1.009 0.47
184_G 394_H 1.009 0.47
561_L 566_V 1.009 0.47
244_I 451_H 1.009 0.47
301_I 455_A 1.006 0.47
328_G 345_T 1.005 0.47
455_A 458_V 1.003 0.47
56_A 124_I 1.003 0.47
36_A 428_G 1.003 0.47
55_Q 59_Q 1.002 0.47
414_Y 417_L 1.002 0.47
194_S 226_T 1.002 0.47
89_G 107_K 1.001 0.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3mixA10.53711000.53Contact Map0.706
3a5iA20.59071000.536Contact Map0.724
3mydA10.59241000.537Contact Map0.66
2x49A10.57511000.546Contact Map0.593
4a5pA30.51121000.557Contact Map0.645
2m0nA10.160625.90.985Contact Map0.344
1nu0A20.195225.70.985Contact Map0.222
3f6pA10.179623.90.985Contact Map0.048
1iv0A10.157218.80.986Contact Map0.196
4fhrB10.269418.60.986Contact Map0.26
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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