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OPENSEQ.org
QUEF - NADPH-dependent 7-cyano-7-deazaguanine reductase
UniProt: Q46920 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13173
Length: 282 (282)
Sequences: 328
Seq/Len: 1.16
QUEF
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
88_I 123_A 2.852 1.00
241_L 269_N 2.584 1.00
68_K 156_T 2.529 1.00
191_L 226_N 2.463 0.99
178_E 206_R 2.402 0.99
191_L 227_E 2.392 0.99
85_V 124_Q 2.39 0.99
105_F 111_V 2.302 0.99
84_S 125_G 2.236 0.99
149_C 184_H 2.183 0.98
210_I 244_C 2.046 0.97
70_L 153_Q 1.956 0.96
59_L 76_G 1.93 0.96
38_N 41_P 1.927 0.96
227_E 235_R 1.879 0.95
224_H 279_L 1.867 0.94
68_K 154_D 1.846 0.94
233_V 253_A 1.828 0.94
93_F 115_L 1.79 0.93
182_V 202_Q 1.724 0.91
102_Q 224_H 1.682 0.89
248_K 270_S 1.64 0.88
106_N 110_E 1.626 0.87
36_S 40_D 1.608 0.86
39_R 256_T 1.578 0.85
148_T 212_R 1.573 0.85
13_L 31_Q 1.572 0.85
81_D 125_G 1.569 0.84
38_N 231_Q 1.547 0.83
59_L 78_V 1.524 0.82
157_I 220_V 1.522 0.82
123_A 157_I 1.498 0.80
37_L 40_D 1.495 0.80
231_Q 235_R 1.449 0.77
250_S 268_S 1.447 0.77
98_N 101_N 1.447 0.77
62_L 115_L 1.444 0.77
38_N 227_E 1.44 0.77
19_T 192_I 1.42 0.75
159_N 163_T 1.404 0.74
33_V 162_F 1.404 0.74
24_T 104_R 1.392 0.73
134_L 137_L 1.373 0.72
54_T 79_E 1.37 0.71
107_N 110_E 1.354 0.70
78_V 93_F 1.329 0.68
123_A 261_L 1.326 0.68
163_T 166_Y 1.321 0.67
23_D 224_H 1.32 0.67
33_V 192_I 1.318 0.67
42_L 184_H 1.315 0.67
227_E 256_T 1.312 0.67
31_Q 37_L 1.308 0.66
109_D 113_Q 1.305 0.66
268_S 271_D 1.299 0.66
179_E 205_Y 1.289 0.65
98_N 119_L 1.279 0.64
149_C 182_V 1.275 0.63
127_I 233_V 1.272 0.63
114_T 117_R 1.271 0.63
175_K 209_Q 1.262 0.62
56_I 60_Y 1.26 0.62
88_I 261_L 1.256 0.62
133_R 136_E 1.233 0.60
189_N 255_Y 1.224 0.59
6_N 88_I 1.215 0.58
14_T 122_C 1.21 0.57
33_V 122_C 1.206 0.57
174_E 245_Q 1.199 0.56
130_A 242_R 1.191 0.56
81_D 120_S 1.19 0.55
31_Q 122_C 1.183 0.55
76_G 82_Y 1.183 0.55
54_T 280_V 1.179 0.54
93_F 261_L 1.179 0.54
32_G 82_Y 1.175 0.54
206_R 248_K 1.175 0.54
101_N 119_L 1.163 0.53
210_I 240_L 1.162 0.53
165_D 240_L 1.161 0.53
206_R 270_S 1.158 0.52
105_F 114_T 1.15 0.52
5_A 8_Q 1.148 0.51
137_L 280_V 1.148 0.51
85_V 125_G 1.139 0.51
22_R 26_D 1.129 0.50
166_Y 214_K 1.126 0.49
14_T 31_Q 1.121 0.49
11_A 199_G 1.12 0.49
72_Q 203_I 1.117 0.48
87_L 217_R 1.117 0.48
155_I 217_R 1.116 0.48
187_K 255_Y 1.116 0.48
240_L 246_P 1.112 0.48
78_V 115_L 1.111 0.48
219_L 236_I 1.104 0.47
179_E 212_R 1.103 0.47
81_D 85_V 1.103 0.47
44_L 155_I 1.098 0.47
81_D 124_Q 1.094 0.46
226_N 231_Q 1.093 0.46
191_L 235_R 1.09 0.46
42_L 202_Q 1.09 0.46
194_H 199_G 1.09 0.46
208_R 242_R 1.083 0.45
10_L 38_N 1.074 0.44
116_E 247_E 1.068 0.44
3_S 124_Q 1.067 0.44
58_T 252_Y 1.066 0.44
37_L 122_C 1.066 0.44
42_L 246_P 1.066 0.44
22_R 191_L 1.064 0.43
145_F 202_Q 1.062 0.43
66_N 203_I 1.061 0.43
41_P 231_Q 1.056 0.43
201_L 219_L 1.056 0.43
150_I 214_K 1.051 0.42
206_R 247_E 1.051 0.42
49_L 115_L 1.042 0.41
113_Q 117_R 1.04 0.41
71_P 207_G 1.04 0.41
191_L 231_Q 1.034 0.41
222_F 235_R 1.034 0.41
37_L 192_I 1.03 0.40
40_D 46_A 1.029 0.40
36_S 122_C 1.028 0.40
8_Q 138_E 1.025 0.40
160_Y 179_E 1.022 0.39
70_L 78_V 1.021 0.39
227_E 231_Q 1.014 0.39
199_G 226_N 1.013 0.39
79_E 128_S 1.01 0.38
38_N 42_L 1.01 0.38
3_S 9_A 1.008 0.38
199_G 255_Y 1.006 0.38
179_E 187_K 1.006 0.38
5_A 9_A 1.005 0.38
58_T 142_I 1.003 0.38
224_H 250_S 1.002 0.38
54_T 202_Q 1 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3uxjA40.99291000.175Contact Map0.516
4f8bA50.51421000.694Contact Map0.635
1wurA50.691596.70.948Contact Map0.481
2f62A20.407843.80.974Contact Map0.387
3ehdA20.407818.40.979Contact Map0.379
3ceiA20.319111.80.98Contact Map0.346
4gioA20.294310.90.981Contact Map0.048
4jenA30.41137.30.982Contact Map0.524
1dt0A30.29084.80.984Contact Map0.256
4jelA10.40434.20.984Contact Map0.169
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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