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OPENSEQ.org
CINAL - NMN amidohydrolase-like protein YfaY
UniProt: P77808 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14087
Length: 400 (376)
Sequences: 844
Seq/Len: 2.24
CINAL
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
308_T 328_S 3.894 1.00
200_T 242_V 3.178 1.00
326_A 338_A 3.069 1.00
260_S 291_P 3.012 1.00
372_N 376_R 2.823 1.00
299_P 310_H 2.815 1.00
4_V 35_L 2.709 1.00
271_T 321_A 2.623 1.00
372_N 375_R 2.62 1.00
5_E 60_H 2.565 1.00
89_G 123_A 2.532 1.00
20_D 23_A 2.473 1.00
281_L 327_V 2.45 1.00
29_F 32_H 2.368 1.00
47_L 84_T 2.287 1.00
268_F 322_G 2.245 1.00
65_I 150_T 2.235 1.00
67_N 157_F 2.218 1.00
270_L 374_L 2.204 1.00
256_P 284_Q 2.187 1.00
305_L 309_A 2.129 1.00
315_R 324_A 2.112 1.00
284_Q 367_A 2.109 1.00
47_L 81_A 2.074 0.99
19_V 24_A 2.056 0.99
313_T 345_T 2.051 0.99
88_E 124_S 1.999 0.99
182_L 233_E 1.978 0.99
316_R 340_A 1.941 0.99
182_L 236_W 1.914 0.99
51_V 84_T 1.87 0.99
282_A 297_V 1.859 0.99
91_V 123_A 1.857 0.98
92_L 120_E 1.812 0.98
294_A 319_H 1.797 0.98
268_F 323_L 1.787 0.98
29_F 162_E 1.785 0.98
39_R 56_E 1.763 0.98
194_L 243_A 1.757 0.98
139_A 168_R 1.742 0.97
98_K 101_E 1.706 0.97
20_D 40_R 1.703 0.97
330_F 334_H 1.696 0.97
264_Q 290_A 1.678 0.97
271_T 315_R 1.663 0.96
46_N 49_D 1.642 0.96
211_Y 220_L 1.638 0.96
293_L 321_A 1.628 0.96
8_S 42_T 1.62 0.96
80_L 117_K 1.618 0.96
309_A 347_A 1.615 0.96
288_A 291_P 1.609 0.95
25_W 162_E 1.584 0.95
137_G 160_M 1.567 0.94
115_N 192_S 1.565 0.94
238_D 241_R 1.564 0.94
236_W 240_K 1.554 0.94
5_E 57_R 1.554 0.94
325_L 339_L 1.543 0.94
54_L 85_A 1.519 0.93
240_K 247_V 1.519 0.93
27_A 40_R 1.486 0.92
27_A 37_L 1.473 0.92
185_T 217_I 1.472 0.92
352_F 369_M 1.453 0.91
186_T 243_A 1.433 0.90
283_L 363_Q 1.429 0.90
104_F 115_N 1.425 0.90
148_F 165_I 1.422 0.90
58_S 145_C 1.42 0.90
206_G 224_G 1.417 0.90
222_L 236_W 1.409 0.89
5_E 41_N 1.382 0.88
118_Q 134_T 1.382 0.88
271_T 324_A 1.376 0.88
92_L 97_L 1.375 0.88
336_N 349_R 1.374 0.88
262_E 375_R 1.373 0.88
298_V 311_W 1.368 0.87
313_T 316_R 1.367 0.87
82_A 149_F 1.346 0.86
122_P 138_F 1.345 0.86
336_N 347_A 1.345 0.86
9_T 50_L 1.34 0.86
283_L 367_A 1.337 0.86
261_R 265_N 1.327 0.85
275_Q 289_G 1.313 0.84
88_E 123_A 1.312 0.84
101_E 105_H 1.301 0.83
149_F 153_V 1.297 0.83
289_G 311_W 1.293 0.83
66_V 149_F 1.29 0.83
189_R 194_L 1.285 0.82
58_S 147_M 1.276 0.82
325_L 374_L 1.272 0.81
131_P 164_E 1.271 0.81
276_F 330_F 1.271 0.81
93_H 96_W 1.269 0.81
62_D 145_C 1.266 0.81
272_L 292_L 1.261 0.81
259_I 371_L 1.261 0.81
189_R 246_S 1.254 0.80
275_Q 331_E 1.251 0.80
153_V 159_V 1.247 0.80
329_G 332_N 1.247 0.80
35_L 169_L 1.246 0.80
289_G 329_G 1.246 0.80
275_Q 304_T 1.239 0.79
289_G 331_E 1.236 0.79
36_P 225_P 1.236 0.79
275_Q 329_G 1.235 0.79
289_G 303_E 1.23 0.78
305_L 349_R 1.23 0.78
260_S 288_A 1.228 0.78
272_L 295_C 1.227 0.78
150_T 153_V 1.227 0.78
275_Q 332_N 1.225 0.78
33_Q 166_L 1.214 0.77
270_L 285_L 1.209 0.77
54_L 64_L 1.203 0.76
104_F 111_M 1.198 0.76
316_R 324_A 1.193 0.75
26_L 161_V 1.192 0.75
131_P 163_H 1.191 0.75
272_L 282_A 1.188 0.75
280_L 363_Q 1.184 0.75
303_E 331_E 1.182 0.74
46_N 208_T 1.182 0.74
18_I 24_A 1.179 0.74
253_E 261_R 1.167 0.73
289_G 332_N 1.153 0.72
181_C 223_T 1.151 0.72
86_K 140_V 1.146 0.71
308_T 326_A 1.145 0.71
58_S 85_A 1.143 0.71
121_L 127_F 1.137 0.70
327_V 366_C 1.137 0.70
184_L 236_W 1.131 0.70
55_R 59_Q 1.128 0.69
276_F 334_H 1.127 0.69
92_L 116_R 1.125 0.69
280_L 367_A 1.122 0.69
222_L 232_M 1.121 0.69
153_V 157_F 1.117 0.68
186_T 189_R 1.117 0.68
113_P 116_R 1.112 0.68
43_V 53_I 1.109 0.68
104_F 190_S 1.094 0.66
4_V 63_V 1.09 0.66
330_F 333_E 1.088 0.65
217_I 248_I 1.087 0.65
186_T 247_V 1.087 0.65
259_I 285_L 1.085 0.65
287_R 311_W 1.084 0.65
94_E 98_K 1.083 0.65
11_D 49_D 1.082 0.65
327_V 370_A 1.081 0.65
275_Q 311_W 1.078 0.64
303_E 329_G 1.077 0.64
329_G 356_R 1.076 0.64
201_L 239_V 1.075 0.64
277_T 356_R 1.072 0.64
42_T 211_Y 1.069 0.63
259_I 375_R 1.064 0.63
310_H 314_E 1.062 0.63
195_A 199_D 1.055 0.62
128_I 139_A 1.054 0.62
5_E 39_R 1.049 0.61
121_L 136_C 1.045 0.61
5_E 61_A 1.04 0.60
311_W 331_E 1.039 0.60
161_V 166_L 1.039 0.60
259_I 262_E 1.038 0.60
9_T 66_V 1.037 0.60
289_G 304_T 1.037 0.60
322_G 342_P 1.037 0.60
304_T 331_E 1.035 0.60
275_Q 303_E 1.034 0.60
240_K 250_E 1.025 0.59
115_N 118_Q 1.025 0.59
337_F 350_V 1.024 0.58
186_T 194_L 1.023 0.58
276_F 333_E 1.02 0.58
287_R 329_G 1.016 0.58
311_W 329_G 1.016 0.58
271_T 319_H 1.013 0.57
51_V 81_A 1.013 0.57
269_S 293_L 1.011 0.57
273_S 311_W 1.008 0.57
340_A 345_T 1.004 0.56
305_L 336_N 1.004 0.56
6_M 30_F 1 0.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kbqA20.4251000.667Contact Map0.717
2a9sA20.34251000.732Contact Map0.643
2is8A30.4051000.759Contact Map0.633
1y5eA30.38751000.761Contact Map0.652
2pjkA30.38251000.764Contact Map0.721
2g2cA10.39251000.765Contact Map0.606
3pzyA10.391000.767Contact Map0.589
1mkzA20.41000.768Contact Map0.608
3rfqA30.38751000.77Contact Map0.671
4lhbA30.38751000.775Contact Map0.61
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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