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OPENSEQ.org
YAGX - Uncharacterized protein YagX
UniProt: P77802 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13563
Length: 841 (737)
Sequences: 1014
Seq/Len: 1.38
YAGX
Paralog alert: 0.79 [within 20: 0.04] - ratio of genomes with paralogs
Cluster includes: ELFC FIMD HTRE SFMD YAGX YBGQ YEHB YFCU YHCD YQIG YRAJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
628_T 644_T 3.655 1.00
660_G 697_Y 3.599 1.00
251_Q 265_Y 3.578 1.00
668_V 700_L 3.557 1.00
750_V 787_D 3.363 1.00
287_V 299_L 2.998 1.00
295_G 336_V 2.922 1.00
362_L 398_G 2.903 1.00
651_W 656_I 2.831 1.00
767_I 793_I 2.82 1.00
671_N 741_E 2.805 1.00
791_P 807_L 2.792 1.00
264_I 391_L 2.723 1.00
765_A 795_F 2.692 1.00
657_A 691_L 2.664 1.00
177_L 195_L 2.653 1.00
439_A 473_Q 2.649 1.00
212_G 227_Y 2.607 1.00
362_L 396_T 2.587 1.00
300_T 305_L 2.585 1.00
498_G 519_Y 2.517 1.00
501_S 518_D 2.471 1.00
296_E 335_I 2.415 1.00
649_V 658_A 2.392 1.00
292_P 339_R 2.381 0.99
292_P 341_I 2.31 0.99
335_I 340_V 2.293 0.99
754_I 805_V 2.251 0.99
521_Q 531_L 2.244 0.99
299_L 318_V 2.239 0.99
331_E 347_R 2.217 0.99
667_G 737_V 2.216 0.99
648_S 660_G 2.162 0.99
652_Q 657_A 2.109 0.98
648_S 663_D 2.102 0.98
298_H 305_L 2.099 0.98
669_I 695_R 2.068 0.98
333_E 340_V 2.011 0.98
300_T 333_E 1.987 0.97
671_N 739_V 1.984 0.97
205_E 233_R 1.935 0.97
767_I 782_F 1.934 0.97
268_S 365_Q 1.928 0.97
597_N 617_Y 1.921 0.97
161_I 164_S 1.895 0.96
654_K 671_N 1.886 0.96
627_G 645_A 1.875 0.96
648_S 667_G 1.868 0.96
490_L 498_G 1.858 0.96
653_G 739_V 1.845 0.96
599_S 615_G 1.828 0.95
630_N 642_N 1.825 0.95
762_L 795_F 1.778 0.94
672_T 675_E 1.777 0.94
748_V 789_K 1.755 0.94
350_K 356_R 1.75 0.94
567_A 578_A 1.745 0.94
169_L 737_V 1.743 0.94
663_D 667_G 1.718 0.93
406_A 433_N 1.698 0.92
232_E 241_A 1.69 0.92
648_S 697_Y 1.687 0.92
170_S 737_V 1.678 0.92
172_N 667_G 1.672 0.92
696_N 699_P 1.667 0.91
252_S 367_W 1.663 0.91
366_V 394_A 1.661 0.91
652_Q 695_R 1.66 0.91
767_I 795_F 1.65 0.91
334_V 341_I 1.647 0.91
243_G 270_G 1.632 0.90
207_H 733_Y 1.623 0.90
665_N 734_P 1.615 0.90
298_H 308_V 1.611 0.89
622_A 625_A 1.606 0.89
132_L 143_L 1.596 0.89
133_D 142_Q 1.589 0.89
672_T 744_V 1.579 0.88
711_Q 714_K 1.576 0.88
159_E 322_G 1.558 0.87
752_G 819_G 1.548 0.87
532_G 556_D 1.537 0.86
274_S 734_P 1.521 0.86
273_A 363_A 1.52 0.85
520_Y 532_G 1.519 0.85
264_I 367_W 1.518 0.85
175_Y 647_G 1.518 0.85
754_I 782_F 1.514 0.85
177_L 193_S 1.495 0.84
654_K 739_V 1.488 0.84
410_Y 470_I 1.488 0.84
566_S 581_S 1.484 0.84
172_N 737_V 1.483 0.84
501_S 504_Y 1.463 0.82
533_L 555_L 1.461 0.82
168_T 236_A 1.458 0.82
803_C 823_C 1.449 0.82
436_N 442_S 1.443 0.81
298_H 335_I 1.441 0.81
719_S 748_V 1.439 0.81
400_L 751_S 1.438 0.81
625_A 645_A 1.435 0.81
650_G 669_I 1.434 0.81
210_L 229_A 1.428 0.80
313_M 318_V 1.421 0.80
169_L 653_G 1.405 0.79
179_V 643_L 1.404 0.79
300_T 331_E 1.393 0.78
288_I 317_E 1.39 0.78
259_I 408_T 1.39 0.78
278_F 704_G 1.389 0.78
805_V 821_V 1.384 0.77
172_N 650_G 1.383 0.77
459_S 485_G 1.372 0.76
234_D 276_T 1.36 0.76
487_T 501_S 1.354 0.75
520_Y 557_L 1.349 0.75
457_G 466_E 1.339 0.74
750_V 809_L 1.336 0.74
264_I 268_S 1.319 0.72
678_G 690_P 1.316 0.72
588_E 680_I 1.313 0.72
273_A 361_P 1.309 0.72
754_I 762_L 1.305 0.71
722_I 725_G 1.304 0.71
756_A 760_T 1.298 0.71
484_I 502_I 1.297 0.71
403_L 422_L 1.291 0.70
406_A 421_R 1.281 0.69
284_A 358_V 1.279 0.69
291_L 311_F 1.275 0.69
200_V 209_V 1.267 0.68
274_S 483_A 1.266 0.68
265_Y 273_A 1.262 0.67
144_V 312_T 1.26 0.67
350_K 470_I 1.257 0.67
334_V 350_K 1.256 0.67
793_I 805_V 1.253 0.67
648_S 737_V 1.251 0.67
481_N 507_D 1.25 0.66
707_E 726_R 1.247 0.66
706_Y 732_L 1.244 0.66
795_F 805_V 1.244 0.66
370_S 388_E 1.242 0.66
332_V 348_V 1.232 0.65
754_I 795_F 1.231 0.65
691_L 697_Y 1.23 0.65
752_G 782_F 1.23 0.65
586_F 596_A 1.224 0.64
675_E 744_V 1.223 0.64
661_R 687_R 1.214 0.63
199_N 210_L 1.21 0.63
234_D 350_K 1.207 0.62
649_V 656_I 1.207 0.62
661_R 688_I 1.205 0.62
135_S 138_Q 1.202 0.62
181_N 191_T 1.202 0.62
287_V 330_V 1.201 0.62
748_V 810_N 1.197 0.61
234_D 241_A 1.195 0.61
371_F 474_L 1.194 0.61
341_I 410_Y 1.194 0.61
491_N 500_F 1.193 0.61
566_S 669_I 1.19 0.61
260_S 469_R 1.188 0.61
629_L 757_E 1.188 0.61
173_L 199_N 1.188 0.61
399_S 404_S 1.187 0.61
258_A 419_E 1.185 0.60
442_S 508_R 1.183 0.60
727_K 740_I 1.182 0.60
490_L 519_Y 1.178 0.60
618_A 629_L 1.178 0.60
622_A 627_G 1.177 0.60
326_G 690_P 1.172 0.59
282_Q 324_P 1.171 0.59
255_P 268_S 1.171 0.59
663_D 737_V 1.164 0.58
287_V 622_A 1.163 0.58
673_G 693_G 1.161 0.58
207_H 234_D 1.16 0.58
427_G 520_Y 1.159 0.58
534_R 537_I 1.158 0.58
502_I 517_A 1.156 0.57
176_N 227_Y 1.154 0.57
613_S 802_T 1.153 0.57
705_R 729_R 1.148 0.57
557_L 824_S 1.146 0.56
299_L 349_N 1.146 0.56
650_G 667_G 1.145 0.56
791_P 809_L 1.145 0.56
313_M 574_G 1.145 0.56
256_M 553_I 1.143 0.56
331_E 349_N 1.14 0.56
537_I 551_K 1.139 0.56
491_N 498_G 1.135 0.55
668_V 708_V 1.134 0.55
251_Q 334_V 1.134 0.55
298_H 570_T 1.132 0.55
523_V 531_L 1.131 0.55
143_L 501_S 1.131 0.55
241_A 352_F 1.126 0.54
460_S 503_S 1.125 0.54
449_S 460_S 1.123 0.54
276_T 596_A 1.122 0.54
201_T 208_V 1.122 0.54
431_N 775_R 1.119 0.54
299_L 557_L 1.118 0.54
252_S 264_I 1.117 0.54
506_D 513_H 1.116 0.53
669_I 739_V 1.116 0.53
152_T 319_D 1.115 0.53
518_D 532_G 1.112 0.53
172_N 777_D 1.11 0.53
423_T 431_N 1.108 0.53
507_D 512_S 1.108 0.53
143_L 634_A 1.108 0.53
318_V 699_P 1.105 0.52
211_D 805_V 1.105 0.52
697_Y 745_K 1.104 0.52
443_S 465_Q 1.102 0.52
337_N 793_I 1.101 0.52
432_V 649_V 1.1 0.52
571_H 574_G 1.094 0.51
234_D 733_Y 1.093 0.51
234_D 237_G 1.093 0.51
233_R 337_N 1.086 0.50
240_F 271_N 1.085 0.50
417_V 435_Q 1.08 0.50
792_T 804_E 1.078 0.50
571_H 575_Y 1.078 0.50
424_L 430_I 1.077 0.50
469_R 477_S 1.076 0.49
398_G 516_T 1.075 0.49
506_D 511_N 1.072 0.49
403_L 556_D 1.07 0.49
149_A 664_G 1.07 0.49
150_L 267_L 1.07 0.49
524_Y 528_F 1.069 0.49
139_L 357_G 1.068 0.49
43_P 46_F 1.067 0.49
365_Q 562_G 1.067 0.49
490_L 503_S 1.066 0.48
372_H 687_R 1.065 0.48
341_I 424_L 1.063 0.48
434_L 500_F 1.063 0.48
357_G 643_L 1.062 0.48
748_V 817_W 1.061 0.48
322_G 644_T 1.058 0.48
400_L 405_W 1.056 0.47
762_L 765_A 1.055 0.47
698_L 708_V 1.055 0.47
752_G 784_M 1.055 0.47
759_G 780_G 1.054 0.47
236_A 733_Y 1.052 0.47
134_L 141_L 1.051 0.47
235_F 238_H 1.049 0.47
229_A 460_S 1.049 0.47
389_S 474_L 1.049 0.47
690_P 749_T 1.048 0.47
420_T 722_I 1.047 0.47
203_L 617_Y 1.046 0.46
265_Y 372_H 1.046 0.46
650_G 737_V 1.046 0.46
645_A 658_A 1.044 0.46
335_I 716_S 1.042 0.46
286_P 319_D 1.039 0.46
565_F 581_S 1.039 0.46
443_S 468_T 1.038 0.46
457_G 472_N 1.037 0.46
652_Q 669_I 1.037 0.46
287_V 754_I 1.035 0.45
293_A 341_I 1.034 0.45
634_A 638_Y 1.034 0.45
295_G 337_N 1.032 0.45
753_R 820_D 1.031 0.45
231_Y 292_P 1.028 0.45
208_V 533_L 1.027 0.45
619_Q 626_S 1.025 0.44
597_N 669_I 1.025 0.44
176_N 646_N 1.024 0.44
750_V 786_V 1.024 0.44
752_G 805_V 1.024 0.44
671_N 695_R 1.023 0.44
282_Q 322_G 1.022 0.44
500_F 608_D 1.022 0.44
256_M 326_G 1.021 0.44
321_R 324_P 1.02 0.44
459_S 664_G 1.02 0.44
257_T 363_A 1.02 0.44
135_S 142_Q 1.019 0.44
255_P 670_F 1.018 0.44
399_S 428_G 1.018 0.44
645_A 648_S 1.016 0.43
638_Y 666_A 1.015 0.43
710_L 725_G 1.015 0.43
174_S 751_S 1.014 0.43
150_L 312_T 1.013 0.43
258_A 397_S 1.01 0.43
229_A 668_V 1.01 0.43
174_S 355_G 1.009 0.43
173_L 614_G 1.008 0.43
134_L 697_Y 1.005 0.42
305_L 335_I 1.004 0.42
171_S 697_Y 1.003 0.42
273_A 281_S 1.002 0.42
361_P 616_A 1.001 0.42
572_Q 713_S 1 0.42
657_A 693_G 1 0.42
417_V 628_T 1 0.42
353_S 356_R 1 0.42
420_T 556_D 1 0.42
359_G 401_S 1 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rfzB20.88351000.31Contact Map0.635
3fipA20.53631000.565Contact Map0.624
3fcgA20.103499.90.858Contact Map0.726
2xetA20.096399.10.918Contact Map0.782
3l48A50.107990.922Contact Map0.9
4b0mA10.146396.50.956Contact Map0.68
3bwuD10.134495.60.96Contact Map0.779
3e8vA10.0844860.969Contact Map0.388
3pe9A40.110652.40.976Contact Map0.651
2chhA10.13252.30.976Contact Map0.542
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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