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OPENSEQ.org
YBCK - Uncharacterized protein YbcK
UniProt: P77698 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13627
Length: 508 (466)
Sequences: 1632
Seq/Len: 3.50
YBCK
Paralog alert: 0.34 [within 20: 0.10] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
45_Y 69_A 6.446 1.00
273_S 276_L 5.681 1.00
199_L 220_H 5.445 1.00
62_A 65_E 4.264 1.00
179_S 190_D 4.146 1.00
205_M 276_L 3.302 1.00
216_Y 220_H 3.175 1.00
199_L 203_L 3.091 1.00
203_L 216_Y 3.046 1.00
274_D 278_Y 2.89 1.00
190_D 193_R 2.606 1.00
70_I 75_I 2.604 1.00
43_I 65_E 2.592 1.00
194_V 198_E 2.584 1.00
144_E 151_R 2.547 1.00
30_E 34_V 2.48 1.00
380_K 414_E 2.458 1.00
6_A 28_I 2.438 1.00
8_M 25_R 2.419 1.00
205_M 280_V 2.37 1.00
3_K 79_T 2.364 1.00
191_P 198_E 2.356 1.00
25_R 44_T 2.351 1.00
308_K 460_K 2.24 1.00
69_A 74_Y 2.203 1.00
308_K 315_T 2.147 1.00
199_L 216_Y 2.099 1.00
203_L 208_R 2.087 1.00
201_F 280_V 2.054 1.00
189_P 271_V 2.04 1.00
200_I 217_L 2.032 1.00
306_V 455_Y 1.948 1.00
179_S 188_V 1.939 1.00
25_R 29_A 1.917 1.00
380_K 383_E 1.898 1.00
144_E 148_K 1.89 1.00
238_E 242_A 1.867 1.00
181_D 188_V 1.865 1.00
87_D 141_A 1.864 1.00
377_L 418_A 1.864 1.00
203_L 220_H 1.858 0.99
381_I 415_L 1.852 0.99
208_R 216_Y 1.846 0.99
241_L 280_V 1.844 0.99
202_K 276_L 1.836 0.99
265_A 274_D 1.835 0.99
244_K 249_I 1.825 0.99
32_L 82_L 1.825 0.99
249_I 265_A 1.813 0.99
214_A 218_N 1.811 0.99
68_D 71_E 1.804 0.99
193_R 225_F 1.799 0.99
277_F 281_Q 1.792 0.99
307_M 349_V 1.757 0.99
202_K 206_E 1.752 0.99
249_I 274_D 1.749 0.99
63_F 66_F 1.743 0.99
314_N 333_M 1.726 0.99
83_V 111_V 1.703 0.99
89_L 100_R 1.698 0.99
87_D 151_R 1.69 0.99
5_I 75_I 1.673 0.99
26_R 30_E 1.663 0.99
310_E 464_N 1.663 0.99
29_A 44_T 1.627 0.98
201_F 246_L 1.624 0.98
63_F 100_R 1.618 0.98
194_V 271_V 1.605 0.98
201_F 272_I 1.605 0.98
214_A 237_I 1.588 0.98
242_A 284_R 1.582 0.98
303_L 461_I 1.575 0.98
346_R 350_D 1.574 0.98
301_N 318_V 1.566 0.98
92_E 142_N 1.564 0.98
176_R 196_T 1.564 0.98
200_I 240_L 1.561 0.98
94_V 98_I 1.56 0.98
56_K 145_S 1.559 0.98
247_I 274_D 1.553 0.98
209_S 212_A 1.553 0.98
128_P 135_I 1.544 0.97
407_K 410_L 1.521 0.97
4_A 38_Y 1.519 0.97
384_L 411_L 1.507 0.97
147_I 151_R 1.506 0.97
5_I 66_F 1.503 0.97
384_L 415_L 1.498 0.97
241_L 281_Q 1.489 0.97
204_R 241_L 1.482 0.96
63_F 89_L 1.462 0.96
201_F 277_F 1.457 0.96
189_P 194_V 1.456 0.96
396_S 407_K 1.445 0.96
244_K 263_E 1.445 0.96
10_F 15_Q 1.439 0.96
5_I 45_Y 1.425 0.95
382_I 385_Q 1.423 0.95
451_R 455_Y 1.417 0.95
374_N 422_L 1.409 0.95
145_S 149_S 1.393 0.95
356_E 359_F 1.387 0.94
66_F 81_L 1.38 0.94
20_S 24_Q 1.375 0.94
12_S 15_Q 1.374 0.94
415_L 419_S 1.369 0.94
176_R 232_W 1.357 0.93
65_E 69_A 1.341 0.93
302_L 329_Y 1.334 0.93
244_K 247_I 1.334 0.93
128_P 143_E 1.329 0.93
70_I 81_L 1.324 0.92
197_I 201_F 1.322 0.92
4_A 32_L 1.321 0.92
203_L 206_E 1.317 0.92
211_N 215_K 1.317 0.92
85_S 147_I 1.317 0.92
270_R 274_D 1.312 0.92
45_Y 66_F 1.305 0.92
85_S 151_R 1.305 0.92
458_F 461_I 1.294 0.91
6_A 40_L 1.293 0.91
381_I 418_A 1.292 0.91
388_I 415_L 1.292 0.91
50_L 57_H 1.288 0.91
178_L 246_L 1.281 0.91
329_Y 346_R 1.278 0.91
247_I 273_S 1.276 0.90
71_E 107_H 1.271 0.90
127_E 146_E 1.265 0.90
218_N 232_W 1.263 0.90
223_K 232_W 1.262 0.90
222_V 232_W 1.252 0.89
177_W 246_L 1.251 0.89
90_S 134_A 1.248 0.89
144_E 147_I 1.247 0.89
373_A 421_S 1.243 0.89
97_A 134_A 1.236 0.88
31_W 35_N 1.235 0.88
276_L 280_V 1.23 0.88
462_I 471_D 1.23 0.88
45_Y 74_Y 1.226 0.88
390_N 395_L 1.222 0.88
196_T 200_I 1.218 0.87
197_I 271_V 1.217 0.87
32_L 36_S 1.215 0.87
28_I 82_L 1.212 0.87
385_Q 415_L 1.209 0.87
249_I 266_G 1.205 0.87
205_M 279_A 1.205 0.87
272_I 280_V 1.204 0.87
246_L 280_V 1.204 0.87
169_I 187_F 1.203 0.87
247_I 277_F 1.203 0.87
200_I 213_I 1.202 0.87
207_R 213_I 1.202 0.87
32_L 40_L 1.202 0.87
404_I 408_I 1.198 0.86
149_S 152_V 1.197 0.86
7_Y 47_D 1.191 0.86
60_S 177_W 1.185 0.85
214_A 234_P 1.185 0.85
216_Y 219_D 1.176 0.85
303_L 353_I 1.174 0.85
250_C 267_Y 1.171 0.85
113_T 118_T 1.169 0.84
406_E 410_L 1.163 0.84
83_V 113_T 1.159 0.84
411_L 415_L 1.153 0.83
301_N 304_R 1.15 0.83
205_M 283_I 1.149 0.83
383_E 387_K 1.148 0.83
70_I 109_I 1.148 0.83
71_E 103_L 1.147 0.83
58_A 63_F 1.139 0.82
131_L 135_I 1.139 0.82
95_G 102_K 1.138 0.82
246_L 272_I 1.137 0.82
197_I 246_L 1.136 0.82
148_K 152_V 1.13 0.82
8_M 44_T 1.128 0.81
278_Y 282_E 1.126 0.81
210_L 238_E 1.126 0.81
90_S 97_A 1.123 0.81
8_M 21_L 1.115 0.80
303_L 350_D 1.112 0.80
387_K 397_V 1.111 0.80
94_V 131_L 1.109 0.80
29_A 33_K 1.1 0.79
67_L 100_R 1.095 0.79
395_L 404_I 1.089 0.78
151_R 154_L 1.082 0.78
311_A 340_D 1.08 0.77
307_M 329_Y 1.078 0.77
52_A 90_S 1.076 0.77
277_F 280_V 1.075 0.77
202_K 205_M 1.07 0.76
197_I 240_L 1.068 0.76
94_V 134_A 1.065 0.76
249_I 267_Y 1.065 0.76
208_R 212_A 1.061 0.76
131_L 134_A 1.058 0.75
105_L 127_E 1.053 0.75
217_L 232_W 1.052 0.75
86_L 130_S 1.05 0.74
312_C 331_C 1.048 0.74
196_T 217_L 1.047 0.74
458_F 463_I 1.047 0.74
10_F 49_G 1.045 0.74
303_L 307_M 1.045 0.74
410_L 414_E 1.044 0.74
204_R 283_I 1.043 0.74
196_T 222_V 1.041 0.74
244_K 251_V 1.04 0.73
27_L 84_E 1.038 0.73
195_K 198_E 1.038 0.73
419_S 423_K 1.037 0.73
129_Y 136_L 1.033 0.73
200_I 237_I 1.031 0.73
213_I 237_I 1.025 0.72
47_D 62_A 1.022 0.72
413_K 417_R 1.02 0.71
58_A 90_S 1.018 0.71
247_I 270_R 1.017 0.71
110_D 121_N 1.012 0.71
181_D 184_R 1.008 0.70
84_E 154_L 1.007 0.70
306_V 454_A 1.003 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4bqqA20.57681000.454Contact Map0.658
4kisA40.60631000.548Contact Map0.815
2r0qC40.39571000.677Contact Map0.634
1gdtA20.35831000.701Contact Map0.652
3guvA10.3151000.703Contact Map0.586
3g13A20.31891000.708Contact Map0.665
3uj3X10.3781000.723Contact Map0.348
3bvpA20.26381000.754Contact Map0.722
3lhkA40.29921000.768Contact Map0.687
3ilxA20.267799.90.778Contact Map0.603
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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