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OPENSEQ.org
PTFC1 - Fructose-like permease IIC component 1
UniProt: P77579 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14154
Length: 415 (363)
Sequences: 826
Seq/Len: 2.28
PTFC1
Paralog alert: 0.59 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: HRSA PTFBC PTFC1 PTFC2 PTFLB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
290_G 393_T 5.338 1.00
134_G 170_I 3.759 1.00
123_G 127_A 3.654 1.00
38_H 121_S 3.438 1.00
49_T 132_F 3.388 1.00
294_A 307_F 3.385 1.00
115_A 170_I 3.383 1.00
347_V 396_M 3.219 1.00
295_T 315_G 3.123 1.00
252_I 258_I 3.101 1.00
111_I 167_A 3.07 1.00
177_L 207_F 2.999 1.00
248_A 346_M 2.852 1.00
282_I 386_I 2.785 1.00
252_I 346_M 2.726 1.00
355_A 359_L 2.544 1.00
337_S 340_T 2.394 1.00
351_V 392_I 2.389 1.00
106_L 133_I 2.382 1.00
109_F 136_L 2.356 1.00
296_I 319_M 2.333 1.00
307_F 398_V 2.249 1.00
264_F 267_F 2.182 1.00
45_R 128_F 2.129 1.00
289_I 390_A 2.079 0.99
362_V 377_T 2.054 0.99
277_V 280_R 1.957 0.99
60_S 100_Q 1.894 0.99
119_A 174_A 1.889 0.99
251_A 349_A 1.864 0.99
57_L 107_F 1.858 0.99
381_V 384_A 1.848 0.98
266_A 280_R 1.841 0.98
251_A 327_S 1.837 0.98
248_A 252_I 1.836 0.98
117_F 120_N 1.83 0.98
131_G 174_A 1.83 0.98
225_G 229_T 1.793 0.98
108_G 136_L 1.755 0.98
97_W 101_S 1.712 0.97
203_L 207_F 1.69 0.97
291_L 397_V 1.689 0.97
292_G 296_I 1.671 0.97
284_I 325_G 1.67 0.97
294_A 398_V 1.659 0.96
292_G 319_M 1.652 0.96
359_L 381_V 1.601 0.95
388_L 392_I 1.601 0.95
222_W 226_G 1.593 0.95
344_S 396_M 1.58 0.95
378_N 381_V 1.576 0.95
169_I 173_V 1.555 0.94
355_A 381_V 1.553 0.94
327_S 349_A 1.545 0.94
178_V 204_S 1.542 0.94
181_M 185_I 1.542 0.94
129_P 205_A 1.534 0.94
223_I 226_G 1.531 0.94
113_M 132_F 1.525 0.94
45_R 117_F 1.502 0.93
313_P 316_K 1.494 0.93
298_D 398_V 1.483 0.92
178_V 200_L 1.483 0.92
351_V 388_L 1.481 0.92
293_L 390_A 1.454 0.91
306_L 403_M 1.451 0.91
180_W 184_K 1.439 0.91
309_A 312_Y 1.431 0.90
278_T 281_S 1.427 0.90
354_T 358_W 1.425 0.90
373_W 379_L 1.392 0.89
281_S 284_I 1.384 0.88
41_S 120_N 1.358 0.87
238_G 241_M 1.353 0.87
130_A 205_A 1.351 0.87
355_A 388_L 1.35 0.87
361_A 381_V 1.339 0.86
285_V 325_G 1.328 0.85
211_A 215_V 1.318 0.85
250_T 284_I 1.31 0.84
254_L 327_S 1.31 0.84
361_A 377_T 1.309 0.84
52_M 205_A 1.295 0.83
39_V 168_L 1.291 0.83
119_A 131_G 1.28 0.82
344_S 400_L 1.279 0.82
227_I 245_G 1.277 0.82
394_A 398_V 1.274 0.82
324_M 371_W 1.274 0.82
251_A 287_P 1.271 0.82
347_V 388_L 1.271 0.82
343_P 346_M 1.267 0.82
181_M 204_S 1.264 0.81
117_F 128_F 1.264 0.81
244_M 354_T 1.262 0.81
337_S 401_R 1.248 0.80
36_P 40_M 1.248 0.80
55_V 202_I 1.24 0.80
293_L 394_A 1.237 0.79
394_A 397_V 1.23 0.79
237_K 240_L 1.23 0.79
342_I 346_M 1.229 0.79
137_M 213_Y 1.228 0.79
246_I 280_R 1.226 0.79
204_S 208_V 1.217 0.78
251_A 345_Y 1.212 0.77
100_Q 104_G 1.208 0.77
221_G 225_G 1.205 0.77
347_V 351_V 1.205 0.77
122_I 172_I 1.201 0.77
250_T 325_G 1.198 0.76
178_V 181_M 1.194 0.76
281_S 285_V 1.194 0.76
224_N 261_A 1.192 0.76
384_A 388_L 1.185 0.75
347_V 392_I 1.181 0.75
173_V 177_L 1.178 0.75
122_I 176_Y 1.176 0.74
185_I 203_L 1.174 0.74
282_I 352_G 1.172 0.74
116_A 132_F 1.166 0.73
181_M 200_L 1.164 0.73
185_I 199_L 1.157 0.73
226_G 230_V 1.151 0.72
134_G 208_V 1.15 0.72
244_M 248_A 1.142 0.71
226_G 229_T 1.137 0.71
281_S 325_G 1.137 0.71
293_L 391_V 1.131 0.70
131_G 135_G 1.129 0.70
132_F 136_L 1.129 0.70
220_G 261_A 1.129 0.70
165_I 169_I 1.109 0.68
195_K 199_L 1.098 0.67
279_A 357_V 1.096 0.67
192_L 195_K 1.094 0.67
355_A 358_W 1.091 0.66
111_I 116_A 1.088 0.66
177_L 208_V 1.083 0.65
395_L 399_F 1.079 0.65
359_L 388_L 1.079 0.65
396_M 400_L 1.079 0.65
390_A 394_A 1.077 0.65
39_V 172_I 1.073 0.64
240_L 358_W 1.063 0.63
234_A 238_G 1.062 0.63
291_L 327_S 1.043 0.61
286_I 352_G 1.034 0.60
377_T 381_V 1.02 0.59
352_G 359_L 1.019 0.58
200_L 204_S 1.016 0.58
341_A 397_V 1.016 0.58
339_I 343_P 1.013 0.58
285_V 371_W 1.012 0.58
259_N 262_A 1.012 0.58
41_S 45_R 1.011 0.57
334_A 341_A 1.007 0.57
300_R 403_M 1 0.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qnqA40.90121000.773Contact Map0.472
2kncA10.115716.60.979Contact Map0.424
3orgA40.559120.981Contact Map0.184
2l8sA10.108410.90.981Contact Map0.51
2nq2A20.33499.70.981Contact Map0.191
2kluA10.09889.20.982Contact Map0.164
2kv5A10.07956.80.983Contact Map0.296
2jwaA20.10125.40.983Contact Map0.68
2ks1B10.1065.20.984Contact Map0.383
4b19A10.07234.70.984Contact Map0.366
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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