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OPENSEQ.org
NHOA - N-hydroxyarylamine O-acetyltransferase
UniProt: P77567 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13780
Length: 281 (257)
Sequences: 665
Seq/Len: 2.59
NHOA
Paralog alert: 0.14 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
28_L 76_F 4.061 1.00
36_I 60_L 3.356 1.00
50_Q 55_S 3.133 1.00
59_K 71_E 3.104 1.00
152_L 161_Q 2.801 1.00
8_Y 32_H 2.46 1.00
76_F 123_V 2.427 1.00
52_D 55_S 2.297 1.00
161_Q 170_S 2.221 1.00
42_D 47_R 2.214 1.00
236_L 245_V 2.157 1.00
150_R 161_Q 2.074 1.00
58_E 63_A 2.031 1.00
51_L 56_P 2.017 0.99
68_Y 188_N 1.988 0.99
57_E 61_V 1.94 0.99
94_V 125_F 1.867 0.99
29_H 133_P 1.858 0.99
90_L 111_L 1.803 0.99
125_F 172_Y 1.737 0.98
5_L 79_V 1.736 0.98
72_Q 79_V 1.733 0.98
39_E 65_R 1.713 0.98
12_I 79_V 1.71 0.98
86_N 113_E 1.692 0.98
21_N 24_T 1.678 0.97
9_F 79_V 1.665 0.97
53_N 78_R 1.656 0.97
65_R 71_E 1.648 0.97
29_H 130_L 1.644 0.97
244_A 248_E 1.641 0.97
68_Y 192_A 1.63 0.97
205_M 246_M 1.595 0.96
56_P 60_L 1.574 0.96
159_V 173_R 1.538 0.95
79_V 83_L 1.53 0.95
43_V 49_I 1.52 0.95
26_R 133_P 1.517 0.95
49_I 192_A 1.512 0.95
135_R 142_Q 1.5 0.94
7_H 62_I 1.498 0.94
29_H 119_W 1.494 0.94
29_H 121_A 1.487 0.94
42_D 65_R 1.474 0.94
14_W 24_T 1.421 0.92
16_G 24_T 1.421 0.92
87_V 110_L 1.395 0.91
88_R 111_L 1.388 0.91
236_L 242_L 1.376 0.90
189_F 193_H 1.358 0.89
77_E 87_V 1.339 0.88
36_I 61_V 1.318 0.87
91_L 179_Q 1.312 0.87
38_F 199_F 1.302 0.86
194_W 200_R 1.289 0.86
90_L 176_L 1.285 0.86
222_F 245_V 1.282 0.85
109_L 120_I 1.278 0.85
9_F 18_A 1.271 0.85
58_E 62_I 1.263 0.84
238_D 241_S 1.259 0.84
39_E 66_G 1.247 0.83
131_T 144_T 1.242 0.83
68_Y 106_T 1.239 0.83
59_K 65_R 1.222 0.81
217_L 222_F 1.206 0.80
38_F 126_G 1.204 0.80
179_Q 184_Y 1.201 0.80
188_N 192_A 1.19 0.79
81_R 89_S 1.189 0.79
16_G 20_V 1.184 0.78
22_I 119_W 1.183 0.78
40_N 200_R 1.179 0.78
106_T 191_S 1.161 0.77
234_R 241_S 1.154 0.76
70_F 91_L 1.154 0.76
85_F 134_I 1.152 0.76
190_W 194_W 1.152 0.76
142_Q 149_Y 1.146 0.75
212_G 226_E 1.145 0.75
44_L 203_L 1.138 0.74
49_I 71_E 1.133 0.74
26_R 29_H 1.132 0.74
32_H 79_V 1.13 0.74
113_E 118_K 1.124 0.73
94_V 126_G 1.122 0.73
150_R 168_W 1.117 0.73
247_Q 253_G 1.116 0.72
64_R 253_G 1.114 0.72
181_Q 188_N 1.109 0.72
12_I 31_K 1.108 0.72
180_Q 183_D 1.107 0.72
28_L 123_V 1.102 0.71
61_V 233_Q 1.102 0.71
151_L 158_W 1.102 0.71
41_L 65_R 1.099 0.71
49_I 59_K 1.094 0.70
14_W 31_K 1.092 0.70
14_W 18_A 1.081 0.69
77_E 89_S 1.075 0.68
93_R 188_N 1.064 0.67
93_R 189_F 1.063 0.67
32_H 72_Q 1.062 0.67
126_G 199_F 1.051 0.66
237_P 241_S 1.042 0.65
167_H 234_R 1.042 0.65
77_E 110_L 1.039 0.65
239_V 243_Y 1.032 0.64
108_R 184_Y 1.031 0.64
38_F 66_G 1.03 0.64
77_E 81_R 1.029 0.63
88_R 178_E 1.024 0.63
130_L 151_L 1.023 0.63
32_H 123_V 1.021 0.63
144_T 147_G 1.018 0.62
49_I 200_R 1.016 0.62
58_E 252_L 1.014 0.62
68_Y 191_S 1.01 0.61
79_V 82_E 1.01 0.61
32_H 188_N 1.008 0.61
108_R 191_S 1 0.60
117_E 135_R 1 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1e2tA811000.062Contact Map0.738
2bszA20.96091000.099Contact Map0.735
2vfbA10.97151000.103Contact Map0.68
1w5rA20.96091000.104Contact Map0.712
4guzA40.94311000.105Contact Map0.749
3d9wA40.96441000.108Contact Map0.732
4c5pA10.97151000.108Contact Map0.683
1w4tA10.9681000.108Contact Map0.713
2ijaA10.95021000.141Contact Map0.707
3lnbA10.92531000.141Contact Map0.721
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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