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OPENSEQ.org
YDIR - Putative electron transfer flavoprotein subunit YdiR
UniProt: P77378 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13977
Length: 312 (308)
Sequences: 1882
Seq/Len: 6.11
YDIR
Paralog alert: 0.42 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FIXB YDIR YGCQ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
297_G 302_V 5.334 1.00
288_F 294_G 3.765 1.00
258_L 279_I 3.289 1.00
199_G 260_I 2.969 1.00
24_A 31_V 2.942 1.00
195_K 253_D 2.776 1.00
22_G 154_C 2.762 1.00
197_V 250_L 2.511 1.00
85_L 95_A 2.471 1.00
200_V 210_L 2.455 1.00
32_Y 53_Y 2.426 1.00
51_C 165_E 2.363 1.00
23_G 26_Q 2.253 1.00
45_M 162_C 2.241 1.00
20_L 84_L 2.204 1.00
227_S 260_I 2.139 1.00
258_L 303_V 2.12 1.00
219_V 307_I 2.079 1.00
216_L 303_V 2.036 1.00
211_K 214_H 2.025 1.00
254_L 277_V 1.993 1.00
278_A 291_A 1.952 1.00
226_C 237_M 1.943 1.00
216_L 307_I 1.929 1.00
75_L 83_L 1.924 1.00
250_L 270_G 1.891 1.00
38_T 56_A 1.872 1.00
25_Q 50_K 1.862 1.00
237_M 241_R 1.857 1.00
200_V 213_V 1.833 1.00
211_K 215_E 1.822 1.00
215_E 307_I 1.806 1.00
214_H 224_V 1.799 1.00
199_G 243_I 1.767 1.00
270_G 273_A 1.754 1.00
213_V 258_L 1.752 1.00
111_T 132_F 1.747 1.00
117_D 136_K 1.746 1.00
198_V 216_L 1.742 1.00
11_S 33_A 1.735 1.00
255_Y 266_H 1.729 1.00
196_R 222_A 1.713 1.00
157_D 160_H 1.7 1.00
123_E 132_F 1.684 1.00
95_A 145_T 1.67 1.00
38_T 58_N 1.664 1.00
210_L 224_V 1.652 1.00
267_M 290_Y 1.643 1.00
197_V 225_G 1.636 1.00
32_Y 50_K 1.612 1.00
275_V 293_Y 1.608 1.00
258_L 299_I 1.604 0.99
30_Q 50_K 1.583 0.99
112_A 123_E 1.583 0.99
110_A 144_I 1.581 0.99
215_E 311_S 1.578 0.99
199_G 257_T 1.55 0.99
278_A 287_I 1.54 0.99
46_P 158_T 1.52 0.99
72_A 101_Q 1.513 0.99
68_A 101_Q 1.513 0.99
219_V 311_S 1.495 0.99
209_D 300_Y 1.493 0.99
30_Q 51_C 1.491 0.99
301_K 305_A 1.473 0.99
216_L 220_L 1.467 0.99
111_T 123_E 1.466 0.99
257_T 260_I 1.465 0.99
204_L 213_V 1.461 0.99
64_T 93_A 1.445 0.99
51_C 163_P 1.43 0.99
110_A 146_L 1.426 0.99
305_A 308_S 1.426 0.99
32_Y 80_P 1.423 0.99
191_L 197_V 1.422 0.99
34_I 71_I 1.421 0.98
226_C 230_I 1.399 0.98
207_Q 237_M 1.385 0.98
215_E 219_V 1.381 0.98
77_D 167_V 1.38 0.98
225_G 243_I 1.376 0.98
38_T 60_A 1.371 0.98
73_A 76_K 1.367 0.98
203_G 236_W 1.364 0.98
212_M 303_V 1.33 0.97
257_T 266_H 1.317 0.97
110_A 113_V 1.315 0.97
190_D 193_K 1.298 0.97
203_G 212_M 1.29 0.97
204_L 209_D 1.285 0.97
67_Y 94_L 1.278 0.97
209_D 212_M 1.27 0.96
19_E 62_Q 1.263 0.96
295_L 302_V 1.253 0.96
75_L 102_L 1.244 0.96
303_V 307_I 1.241 0.96
109_D 147_A 1.236 0.96
98_L 143_I 1.226 0.95
199_G 227_S 1.225 0.95
78_K 165_E 1.208 0.95
107_V 110_A 1.207 0.95
45_M 157_D 1.176 0.94
71_I 98_L 1.169 0.93
19_E 141_L 1.169 0.93
253_D 274_K 1.166 0.93
84_L 144_I 1.165 0.93
206_A 236_W 1.159 0.93
210_L 230_I 1.158 0.93
238_E 241_R 1.146 0.93
20_L 86_A 1.144 0.92
204_L 299_I 1.143 0.92
214_H 218_A 1.143 0.92
73_A 77_D 1.142 0.92
69_E 73_A 1.141 0.92
72_A 98_L 1.139 0.92
203_G 209_D 1.129 0.92
53_Y 167_V 1.121 0.91
49_P 52_L 1.115 0.91
8_W 74_L 1.112 0.91
305_A 309_Q 1.105 0.91
6_S 30_Q 1.102 0.91
14_P 18_A 1.102 0.91
21_F 47_Y 1.094 0.90
121_C 134_Q 1.091 0.90
19_E 28_G 1.088 0.90
7_V 24_A 1.088 0.90
212_M 215_E 1.086 0.90
196_R 256_L 1.082 0.89
36_Q 70_S 1.073 0.89
27_W 84_L 1.072 0.89
45_M 160_H 1.068 0.89
218_A 221_N 1.065 0.88
19_E 149_G 1.063 0.88
226_C 231_A 1.061 0.88
288_F 296_V 1.06 0.88
191_L 225_G 1.058 0.88
28_G 63_R 1.049 0.87
43_A 156_S 1.04 0.87
114_D 123_E 1.039 0.87
34_I 74_L 1.039 0.87
12_D 88_T 1.038 0.87
81_A 141_L 1.037 0.87
7_V 27_W 1.035 0.86
212_M 307_I 1.03 0.86
206_A 209_D 1.03 0.86
219_V 310_L 1.026 0.86
198_V 303_V 1.02 0.85
243_I 270_G 1.015 0.85
99_S 143_I 1.012 0.85
61_L 181_R 1.01 0.85
299_I 304_P 1.01 0.85
21_F 49_P 1.01 0.85
11_S 44_V 1.008 0.84
126_M 131_A 1.004 0.84
200_V 230_I 1 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1efvA10.97441000.073Contact Map0.809
1o97D10.96791000.076Contact Map0.686
1efpA20.94871000.092Contact Map0.784
3ih5A40.60261000.665Contact Map0.802
3fetA40.53211000.725Contact Map0.746
1efvB10.657199.90.761Contact Map0.685
1efpB20.647499.90.769Contact Map0.699
1o97C10.663599.90.775Contact Map0.7
2pgnA20.929595.20.937Contact Map0.604
1ozhA40.926395.10.938Contact Map0.655
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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