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OPENSEQ.org
YFBL - Uncharacterized protein YfbL
UniProt: P76482 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14096
Length: 323 (297)
Sequences: 1096
Seq/Len: 3.69
YFBL
Paralog alert: 0.29 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: IAP YFBL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
45_V 135_A 2.958 1.00
143_E 146_R 2.923 1.00
140_G 197_I 2.891 1.00
74_F 161_A 2.66 1.00
71_K 75_V 2.657 1.00
138_V 161_A 2.415 1.00
84_Q 179_V 2.402 1.00
73_V 76_S 2.36 1.00
48_L 66_S 2.324 1.00
67_A 94_K 2.202 1.00
102_P 156_G 2.202 1.00
303_L 308_M 2.151 1.00
107_L 156_G 2.131 1.00
71_K 83_S 2.08 1.00
45_V 139_A 2 1.00
141_L 161_A 1.987 1.00
111_G 162_Y 1.879 1.00
299_T 302_R 1.873 1.00
104_D 154_K 1.872 1.00
292_Q 297_G 1.845 1.00
44_T 69_Y 1.845 1.00
106_P 155_T 1.809 0.99
70_I 114_Y 1.788 0.99
42_E 46_R 1.777 0.99
112_A 138_V 1.764 0.99
300_A 305_Y 1.758 0.99
55_R 135_A 1.706 0.99
111_G 191_M 1.706 0.99
61_D 65_R 1.7 0.99
63_L 163_A 1.682 0.99
41_L 312_V 1.672 0.99
38_P 306_Q 1.665 0.99
47_Y 73_V 1.612 0.98
41_L 45_V 1.592 0.98
162_Y 177_S 1.574 0.98
141_L 159_L 1.557 0.98
42_E 305_Y 1.556 0.98
68_E 72_E 1.538 0.98
109_I 188_V 1.536 0.98
66_S 114_Y 1.504 0.97
158_Q 180_H 1.489 0.97
70_I 161_A 1.482 0.97
181_A 272_Y 1.465 0.97
135_A 139_A 1.452 0.96
135_A 161_A 1.441 0.96
41_L 308_M 1.428 0.96
292_Q 302_R 1.404 0.95
99_D 158_Q 1.389 0.95
49_T 300_A 1.385 0.95
74_F 98_A 1.368 0.94
162_Y 191_M 1.367 0.94
153_P 157_V 1.364 0.94
62_N 65_R 1.355 0.94
47_Y 50_Q 1.35 0.94
63_L 66_S 1.345 0.94
44_T 73_V 1.337 0.93
64_N 68_E 1.326 0.93
39_E 42_E 1.316 0.93
133_D 294_H 1.307 0.92
199_Y 292_Q 1.301 0.92
116_S 130_G 1.295 0.92
98_A 145_A 1.294 0.92
112_A 137_G 1.285 0.92
70_I 142_L 1.285 0.92
181_A 275_H 1.28 0.91
107_L 158_Q 1.278 0.91
40_Q 143_E 1.267 0.91
26_V 31_S 1.259 0.90
132_D 136_S 1.257 0.90
110_I 319_L 1.251 0.90
67_A 96_I 1.245 0.90
134_N 193_A 1.245 0.90
266_F 270_L 1.244 0.90
46_R 300_A 1.221 0.89
74_F 142_L 1.22 0.89
48_L 70_I 1.22 0.89
116_S 128_T 1.219 0.88
132_D 290_N 1.216 0.88
73_V 142_L 1.216 0.88
164_S 175_M 1.216 0.88
27_N 30_P 1.214 0.88
106_P 189_K 1.213 0.88
99_D 156_G 1.206 0.88
267_S 293_Y 1.203 0.88
25_W 28_A 1.193 0.87
143_E 147_L 1.19 0.87
30_P 33_P 1.189 0.87
54_P 62_N 1.187 0.87
67_A 83_S 1.182 0.86
67_A 163_A 1.179 0.86
132_D 196_M 1.175 0.86
100_Y 148_L 1.165 0.85
198_G 303_L 1.158 0.85
110_I 144_L 1.148 0.84
64_N 67_A 1.145 0.84
196_M 269_H 1.118 0.82
268_D 294_H 1.117 0.82
26_V 30_P 1.114 0.82
90_G 142_L 1.112 0.81
156_G 189_K 1.111 0.81
117_A 128_T 1.111 0.81
164_S 167_P 1.11 0.81
40_Q 73_V 1.109 0.81
123_D 126_T 1.104 0.81
97_V 160_V 1.095 0.80
113_H 268_D 1.094 0.80
81_V 98_A 1.093 0.80
181_A 184_L 1.084 0.79
195_E 281_M 1.082 0.79
49_T 131_A 1.082 0.79
51_T 129_P 1.078 0.79
83_S 96_I 1.078 0.79
311_V 314_G 1.076 0.78
167_P 175_M 1.072 0.78
166_E 294_H 1.068 0.78
270_L 274_Q 1.064 0.77
281_M 290_N 1.062 0.77
241_K 244_L 1.061 0.77
178_A 271_N 1.06 0.77
294_H 298_D 1.057 0.77
129_P 148_L 1.054 0.76
66_S 153_P 1.05 0.76
37_S 40_Q 1.048 0.76
109_I 160_V 1.043 0.75
57_A 93_Y 1.043 0.75
132_D 199_Y 1.042 0.75
134_N 195_E 1.041 0.75
72_E 306_Q 1.037 0.75
232_Q 280_I 1.037 0.75
195_E 269_H 1.036 0.75
134_N 137_G 1.035 0.74
196_M 267_S 1.031 0.74
84_Q 183_S 1.025 0.73
179_V 183_S 1.025 0.73
91_G 164_S 1.023 0.73
133_D 165_E 1.021 0.73
112_A 161_A 1.021 0.73
81_V 116_S 1.014 0.72
136_S 303_L 1.007 0.72
72_E 75_V 1.003 0.71
54_P 116_S 1.002 0.71
132_D 281_M 1.001 0.71
73_V 77_S 1 0.71
129_P 299_T 1 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2afwA20.871000.491Contact Map0.748
2ek8A10.78951000.498Contact Map0.777
3pb6X10.88541000.505Contact Map0.743
4fuuA10.86071000.507Contact Map0.698
3tc8A20.85451000.513Contact Map0.697
4faiA20.89471000.513Contact Map0.723
4f9uA20.82661000.514Contact Map0.706
3guxA20.86071000.515Contact Map0.705
1rtqA10.84521000.518Contact Map0.638
1tkjA10.76781000.52Contact Map0.714
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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