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OPENSEQ.org

RCNA - Nickel/cobalt efflux system RcnA
UniProt: P76425 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14071
Length: 274 (269)
Sequences: 385
Seq/Len: 1.43

RCNA
Paralog alert: 0.23 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
156_A 163_R 2.488 1.00
210_V 214_S 2.032 0.98
63_H 185_I 1.973 0.98
171_T 218_A 1.759 0.94
63_H 217_L 1.754 0.94
140_H 143_H 1.748 0.94
127_H 132_H 1.743 0.94
129_H 132_H 1.734 0.94
96_V 100_S 1.668 0.92
127_H 131_D 1.649 0.91
136_H 140_H 1.618 0.90
131_D 135_H 1.609 0.90
63_H 188_P 1.58 0.89
66_V 211_V 1.551 0.88
185_I 217_L 1.539 0.87
5_T 211_V 1.524 0.86
142_H 145_E 1.502 0.85
141_H 144_H 1.501 0.85
134_H 137_D 1.485 0.84
140_H 146_H 1.484 0.84
136_H 143_H 1.474 0.84
138_H 145_E 1.465 0.83
182_G 202_A 1.455 0.83
137_D 140_H 1.442 0.82
140_H 144_H 1.429 0.81
139_G 143_H 1.424 0.81
141_H 146_H 1.406 0.80
140_H 145_E 1.398 0.79
137_D 143_H 1.385 0.78
65_A 185_I 1.366 0.77
23_L 30_E 1.359 0.76
137_D 146_H 1.355 0.76
69_L 259_L 1.353 0.76
138_H 142_H 1.333 0.74
133_E 136_H 1.327 0.74
137_D 145_E 1.32 0.73
180_L 211_V 1.316 0.73
14_W 18_P 1.315 0.73
241_G 255_L 1.302 0.72
4_F 11_G 1.294 0.71
139_G 144_H 1.277 0.70
134_H 143_H 1.271 0.69
137_D 141_H 1.266 0.69
4_F 9_Q 1.262 0.69
138_H 146_H 1.257 0.68
141_H 147_G 1.25 0.67
128_H 136_H 1.247 0.67
185_I 188_P 1.244 0.67
30_E 213_F 1.242 0.67
57_L 222_V 1.242 0.67
139_G 142_H 1.24 0.67
138_H 143_H 1.238 0.66
122_G 126_E 1.235 0.66
135_H 143_H 1.233 0.66
3_E 6_T 1.228 0.65
29_L 229_A 1.224 0.65
29_L 57_L 1.222 0.65
257_I 260_V 1.217 0.64
139_G 147_G 1.211 0.64
55_L 179_G 1.21 0.64
127_H 136_H 1.209 0.64
142_H 146_H 1.201 0.63
60_T 221_L 1.2 0.63
139_G 145_E 1.196 0.62
120_M 124_D 1.183 0.61
127_H 134_H 1.182 0.61
132_H 138_H 1.18 0.61
99_I 258_G 1.18 0.61
78_S 81_F 1.175 0.60
46_K 196_I 1.166 0.60
22_L 111_R 1.156 0.59
135_H 140_H 1.156 0.59
137_D 144_H 1.154 0.58
122_G 125_Y 1.151 0.58
23_L 189_A 1.144 0.57
141_H 145_E 1.142 0.57
135_H 141_H 1.137 0.57
133_E 137_D 1.136 0.57
143_H 146_H 1.136 0.57
132_H 137_D 1.134 0.56
106_F 254_S 1.13 0.56
111_R 184_L 1.128 0.56
127_H 135_H 1.128 0.56
254_S 261_G 1.127 0.56
134_H 140_H 1.126 0.56
3_E 9_Q 1.121 0.55
57_L 223_T 1.119 0.55
193_V 212_S 1.116 0.55
67_V 170_V 1.109 0.54
183_G 220_T 1.108 0.54
139_G 146_H 1.105 0.53
188_P 217_L 1.103 0.53
54_M 93_I 1.102 0.53
20_A 40_A 1.1 0.53
195_L 205_L 1.099 0.53
236_A 239_W 1.096 0.53
134_H 139_G 1.092 0.52
91_Q 213_F 1.085 0.51
132_H 135_H 1.085 0.51
133_E 139_G 1.082 0.51
133_E 138_H 1.081 0.51
243_N 264_M 1.075 0.50
20_A 209_L 1.073 0.50
133_E 140_H 1.073 0.50
128_H 135_H 1.072 0.50
108_R 174_Q 1.071 0.50
53_V 68_W 1.068 0.50
55_L 217_L 1.068 0.50
63_H 213_F 1.067 0.50
60_T 182_G 1.064 0.49
135_H 138_H 1.064 0.49
144_H 147_G 1.061 0.49
106_F 251_Y 1.055 0.48
138_H 144_H 1.054 0.48
72_F 75_M 1.053 0.48
127_H 137_D 1.053 0.48
213_F 217_L 1.052 0.48
29_L 95_A 1.051 0.48
34_S 102_A 1.05 0.48
129_H 143_H 1.05 0.48
104_W 221_L 1.049 0.48
136_H 139_G 1.047 0.48
52_A 196_I 1.046 0.47
175_I 224_V 1.046 0.47
106_F 258_G 1.043 0.47
262_V 266_V 1.04 0.47
139_G 270_M 1.039 0.47
135_H 139_G 1.039 0.47
61_I 208_T 1.035 0.46
17_I 176_L 1.031 0.46
15_F 169_E 1.03 0.46
91_Q 188_P 1.03 0.46
185_I 213_F 1.026 0.45
48_T 227_G 1.024 0.45
136_H 146_H 1.022 0.45
10_Q 231_S 1.021 0.45
105_M 224_V 1.019 0.45
5_T 9_Q 1.011 0.44
91_Q 185_I 1.006 0.43
63_H 66_V 1.005 0.43
153_H 157_H 1.002 0.43
95_A 98_I 1.002 0.43
36_T 182_G 1.002 0.43
241_G 259_L 1.002 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
4g1uA20.361313.10.961Contact Map0.368
3dh4A40.43810.50.962Contact Map0.184
2f93B10.35410.20.963Contact Map0.098
4dveA30.45999.40.963Contact Map0.199
4knfA50.41247.60.965Contact Map0.239
3llqA20.47087.50.965Contact Map0.204
4hyjA20.4275.60.967Contact Map0.081
3h90A40.35045.20.967Contact Map0.476
4bx8A20.41244.70.968Contact Map0.139
3fewX10.39783.10.971Contact Map0.188

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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