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OPENSEQ.org
C56H - Cytochrome b561 homolog 1
UniProt: P76345 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14050
Length: 176 (174)
Sequences: 1273
Seq/Len: 7.32
C56H
Paralog alert: 0.77 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: C561 C56H C56I
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
158_F 163_Q 4.202 1.00
157_L 161_Y 3.149 1.00
103_I 107_A 3.144 1.00
19_V 95_F 2.841 1.00
15_T 57_M 2.704 1.00
8_Q 63_I 2.504 1.00
89_I 93_I 2.438 1.00
160_H 167_T 2.334 1.00
26_M 29_R 2.226 1.00
48_N 116_L 2.22 1.00
7_T 63_I 2.046 1.00
87_M 151_A 2.039 1.00
15_T 95_F 2.031 1.00
77_P 80_Q 1.976 1.00
15_T 56_L 1.942 1.00
57_M 95_F 1.879 1.00
5_S 8_Q 1.871 1.00
5_S 63_I 1.87 1.00
82_K 85_S 1.861 1.00
160_H 168_L 1.836 1.00
5_S 67_Y 1.738 1.00
10_Y 14_I 1.701 1.00
160_H 169_L 1.677 1.00
57_M 96_L 1.571 1.00
8_Q 67_Y 1.541 1.00
149_I 153_A 1.536 1.00
136_N 139_E 1.526 0.99
47_Y 106_M 1.497 0.99
52_F 115_F 1.488 0.99
151_A 155_A 1.412 0.99
160_H 166_N 1.395 0.99
162_I 165_D 1.388 0.99
130_I 133_L 1.379 0.99
63_I 67_Y 1.377 0.99
54_W 103_I 1.367 0.99
167_T 170_R 1.353 0.98
100_L 104_A 1.344 0.98
55_V 62_I 1.329 0.98
107_A 123_F 1.308 0.98
38_T 42_M 1.294 0.98
87_M 155_A 1.281 0.98
86_L 89_I 1.276 0.98
145_G 149_I 1.258 0.97
104_A 134_I 1.253 0.97
84_A 87_M 1.247 0.97
26_M 31_W 1.237 0.97
11_L 59_S 1.236 0.97
61_L 96_L 1.235 0.97
27_E 31_W 1.223 0.97
127_N 130_I 1.221 0.97
27_E 32_F 1.217 0.96
25_A 31_W 1.203 0.96
51_I 113_W 1.16 0.95
7_T 10_Y 1.151 0.95
19_V 57_M 1.151 0.95
78_A 82_K 1.148 0.95
97_A 141_W 1.147 0.95
150_A 154_G 1.145 0.95
38_T 41_L 1.144 0.95
92_Y 95_F 1.142 0.94
155_A 165_D 1.139 0.94
23_Y 149_I 1.135 0.94
64_K 69_D 1.125 0.94
4_F 8_Q 1.123 0.94
39_Y 42_M 1.106 0.93
46_H 50_G 1.105 0.93
21_I 49_A 1.103 0.93
82_K 86_L 1.101 0.93
22_T 53_V 1.099 0.93
25_A 29_R 1.098 0.93
78_A 81_M 1.089 0.92
147_F 151_A 1.083 0.92
73_V 167_T 1.082 0.92
25_A 33_P 1.082 0.92
58_F 62_I 1.071 0.92
95_F 99_P 1.069 0.92
28_L 33_P 1.059 0.91
54_W 99_P 1.057 0.91
166_N 169_L 1.055 0.91
52_F 116_L 1.037 0.90
101_L 142_A 1.031 0.89
143_N 147_F 1.024 0.89
45_T 49_A 1.009 0.88
15_T 19_V 1.009 0.88
86_L 90_M 1.008 0.88
76_P 167_T 1.006 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gd3A20.99431000.432Contact Map0.345
1kqfC10.897799.90.498Contact Map0.504
1q16C10.914816.90.94Contact Map0.419
3cx5C20.67057.80.948Contact Map0.437
1qleC10.56823.20.957Contact Map0.194
1v54C20.568230.957Contact Map0.257
1fftC20.57392.90.958Contact Map0.129
1pp9C20.67052.60.959Contact Map0.383
1m56C20.55112.40.96Contact Map0.242
2yevA20.55682.30.96Contact Map0.252
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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