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OPENSEQ.org
FLHA - Flagellar biosynthesis protein FlhA
UniProt: P76298 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14273
Length: 692 (671)
Sequences: 914
Seq/Len: 1.36
FLHA
Paralog alert: 0.43 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: FHIA FLHA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
543_N 575_T 4.041 1.00
234_S 237_H 3.759 1.00
220_I 243_T 3.26 1.00
296_A 321_L 3.198 1.00
213_I 217_V 3.131 1.00
180_E 183_K 2.985 1.00
426_E 429_S 2.924 1.00
293_L 324_A 2.874 1.00
505_G 508_E 2.844 1.00
122_N 230_Q 2.695 1.00
553_D 556_T 2.653 1.00
455_V 462_N 2.546 1.00
225_L 229_L 2.544 1.00
428_G 495_L 2.516 1.00
648_L 669_L 2.374 0.99
513_L 558_L 2.358 0.99
366_E 410_N 2.329 0.99
296_A 317_T 2.328 0.99
67_R 187_E 2.325 0.99
99_E 102_T 2.318 0.99
233_M 241_S 2.236 0.99
148_I 269_T 2.164 0.99
300_G 317_T 2.106 0.98
322_G 326_W 2.103 0.98
418_Y 491_H 2.078 0.98
610_L 654_L 2.063 0.98
417_R 429_S 2.012 0.98
528_V 537_L 1.995 0.98
81_T 260_I 1.985 0.97
293_L 321_L 1.985 0.97
556_T 560_T 1.95 0.97
550_P 585_A 1.945 0.97
659_S 663_R 1.934 0.97
228_V 235_M 1.919 0.97
44_L 92_S 1.917 0.97
531_V 565_A 1.914 0.97
561_L 574_L 1.91 0.97
433_Y 452_E 1.894 0.96
587_T 678_S 1.869 0.96
54_L 81_T 1.863 0.96
532_V 561_L 1.848 0.96
432_A 488_V 1.84 0.95
662_L 669_L 1.816 0.95
148_I 264_A 1.8 0.95
217_V 221_V 1.765 0.94
246_T 250_G 1.751 0.94
442_P 480_T 1.741 0.93
436_R 467_E 1.731 0.93
49_T 110_V 1.715 0.93
34_M 91_A 1.674 0.91
483_E 486_T 1.671 0.91
499_H 502_E 1.66 0.91
179_D 182_K 1.64 0.90
414_Q 417_R 1.638 0.90
516_V 558_L 1.619 0.90
90_V 133_L 1.601 0.89
306_P 313_F 1.598 0.89
439_A 466_I 1.594 0.89
502_E 584_R 1.589 0.88
532_V 537_L 1.569 0.88
504_F 509_A 1.55 0.87
221_V 225_L 1.546 0.86
406_H 421_L 1.542 0.86
92_S 111_V 1.53 0.86
310_N 314_L 1.529 0.86
148_I 206_R 1.523 0.85
422_M 427_I 1.509 0.85
55_S 212_G 1.5 0.84
49_T 313_F 1.495 0.84
303_G 310_N 1.495 0.84
98_M 125_I 1.486 0.83
632_T 662_L 1.477 0.83
390_I 489_A 1.466 0.82
212_G 249_D 1.462 0.82
560_T 564_H 1.457 0.82
112_E 116_H 1.448 0.81
512_L 554_M 1.447 0.81
143_K 146_G 1.445 0.81
67_R 70_E 1.444 0.81
541_L 551_I 1.438 0.81
308_M 312_V 1.432 0.80
100_G 233_M 1.423 0.80
513_L 534_L 1.418 0.79
77_I 281_M 1.408 0.79
420_I 492_L 1.405 0.78
648_L 658_L 1.404 0.78
41_A 428_G 1.403 0.78
124_A 225_L 1.398 0.78
141_I 257_A 1.395 0.78
652_H 675_L 1.387 0.77
504_F 541_L 1.387 0.77
145_A 242_Y 1.386 0.77
423_K 553_D 1.385 0.77
224_L 235_M 1.385 0.77
433_Y 436_R 1.381 0.77
466_I 474_A 1.381 0.77
233_M 237_H 1.375 0.76
318_A 322_G 1.373 0.76
73_A 77_I 1.367 0.76
306_P 309_P 1.361 0.75
141_I 262_T 1.36 0.75
177_G 180_E 1.359 0.75
438_L 454_T 1.352 0.75
32_L 91_A 1.349 0.74
386_R 424_G 1.348 0.74
610_L 658_L 1.338 0.73
35_M 90_V 1.335 0.73
102_T 108_G 1.333 0.73
453_A 464_I 1.332 0.73
603_D 690_G 1.331 0.73
672_L 683_I 1.329 0.73
506_R 538_H 1.324 0.72
135_I 214_L 1.322 0.72
321_L 325_W 1.321 0.72
92_S 212_G 1.319 0.72
635_A 638_R 1.318 0.72
188_V 192_A 1.316 0.72
553_D 585_A 1.311 0.71
550_P 589_Q 1.31 0.71
89_N 212_G 1.308 0.71
537_L 561_L 1.295 0.70
127_I 239_A 1.289 0.69
365_M 533_T 1.288 0.69
26_I 29_L 1.288 0.69
137_N 536_T 1.283 0.69
206_R 264_A 1.282 0.69
376_D 379_Q 1.279 0.69
35_M 133_L 1.276 0.68
236_G 239_A 1.276 0.68
139_M 212_G 1.27 0.68
297_A 324_A 1.264 0.67
127_I 243_T 1.256 0.67
206_R 435_G 1.255 0.66
35_M 98_M 1.254 0.66
183_K 187_E 1.252 0.66
369_Y 415_P 1.247 0.66
247_I 308_M 1.246 0.66
461_L 480_T 1.246 0.66
534_L 537_L 1.24 0.65
569_S 662_L 1.239 0.65
61_V 285_L 1.235 0.65
160_M 188_V 1.235 0.65
78_L 260_I 1.231 0.64
527_L 565_A 1.23 0.64
57_M 295_S 1.228 0.64
80_F 540_V 1.221 0.63
51_N 260_I 1.221 0.63
48_F 51_N 1.213 0.63
69_L 561_L 1.205 0.62
37_L 91_A 1.203 0.62
44_L 91_A 1.202 0.62
398_M 500_A 1.199 0.61
658_L 663_R 1.198 0.61
195_Y 262_T 1.197 0.61
321_L 513_L 1.188 0.60
32_L 206_R 1.187 0.60
178_E 395_A 1.182 0.60
375_V 597_V 1.181 0.59
419_R 429_S 1.18 0.59
50_F 54_L 1.179 0.59
532_V 536_T 1.172 0.59
523_L 555_R 1.169 0.58
288_N 291_V 1.164 0.58
242_Y 375_V 1.154 0.57
143_K 264_A 1.154 0.57
662_L 671_V 1.153 0.57
437_W 468_S 1.153 0.57
265_G 506_R 1.152 0.57
457_P 490_T 1.152 0.57
168_D 209_A 1.149 0.56
365_M 488_V 1.149 0.56
551_I 554_M 1.147 0.56
143_K 212_G 1.146 0.56
69_L 289_P 1.146 0.56
363_L 420_I 1.143 0.56
195_Y 276_D 1.14 0.55
22_L 25_P 1.138 0.55
64_F 213_I 1.138 0.55
206_R 209_A 1.138 0.55
242_Y 246_T 1.136 0.55
440_I 456_D 1.135 0.55
64_F 294_L 1.134 0.55
247_I 657_L 1.134 0.55
298_V 316_F 1.133 0.55
197_S 689_I 1.13 0.54
233_M 242_Y 1.128 0.54
209_A 257_A 1.127 0.54
367_V 406_H 1.125 0.54
58_V 81_T 1.125 0.54
92_S 95_I 1.122 0.54
138_F 257_A 1.12 0.53
49_T 316_F 1.119 0.53
528_V 558_L 1.118 0.53
260_I 395_A 1.116 0.53
224_L 238_A 1.115 0.53
300_G 314_L 1.11 0.52
261_S 552_R 1.109 0.52
517_A 525_E 1.108 0.52
406_H 517_A 1.107 0.52
51_N 595_D 1.105 0.52
575_T 597_V 1.103 0.52
39_L 363_L 1.103 0.52
549_V 590_W 1.102 0.52
178_E 538_H 1.099 0.51
32_L 259_V 1.098 0.51
28_I 63_M 1.097 0.51
66_Q 70_E 1.096 0.51
363_L 496_I 1.093 0.51
340_P 469_A 1.092 0.51
195_Y 267_I 1.09 0.50
83_L 263_A 1.088 0.50
239_A 243_T 1.087 0.50
516_V 527_L 1.087 0.50
459_F 490_T 1.084 0.50
652_H 673_S 1.083 0.50
482_V 490_T 1.082 0.50
176_I 184_R 1.08 0.49
432_A 438_L 1.08 0.49
308_M 313_F 1.079 0.49
62_A 267_I 1.077 0.49
470_L 473_Q 1.077 0.49
41_A 206_R 1.073 0.49
21_I 25_P 1.073 0.49
28_I 80_F 1.073 0.49
94_R 132_I 1.072 0.49
207_G 254_Q 1.071 0.49
303_G 307_G 1.071 0.49
222_G 247_I 1.069 0.48
614_L 618_G 1.068 0.48
216_M 595_D 1.068 0.48
392_K 493_N 1.067 0.48
138_F 295_S 1.067 0.48
78_L 220_I 1.065 0.48
564_H 574_L 1.062 0.48
73_A 317_T 1.06 0.47
265_G 395_A 1.06 0.47
48_F 308_M 1.057 0.47
149_A 552_R 1.056 0.47
185_R 211_A 1.055 0.47
84_L 270_R 1.053 0.47
80_F 266_V 1.052 0.47
503_L 545_L 1.051 0.47
138_F 254_Q 1.05 0.46
524_T 558_L 1.049 0.46
135_I 233_M 1.048 0.46
226_V 230_Q 1.048 0.46
423_K 556_T 1.047 0.46
221_V 648_L 1.047 0.46
363_L 571_P 1.047 0.46
554_M 558_L 1.045 0.46
600_I 651_N 1.045 0.46
314_L 318_A 1.044 0.46
499_H 650_V 1.043 0.46
106_A 137_N 1.042 0.46
83_L 264_A 1.039 0.45
387_I 486_T 1.039 0.45
237_H 241_S 1.037 0.45
458_A 479_Y 1.036 0.45
412_D 440_I 1.036 0.45
369_Y 372_I 1.033 0.45
136_I 230_Q 1.033 0.45
149_A 507_Q 1.031 0.45
21_I 290_S 1.03 0.44
611_L 653_A 1.028 0.44
85_R 208_D 1.028 0.44
34_M 87_A 1.027 0.44
510_Q 514_D 1.027 0.44
71_F 77_I 1.024 0.44
363_L 422_M 1.024 0.44
237_H 240_E 1.023 0.44
243_T 526_D 1.022 0.44
267_I 272_S 1.021 0.44
63_M 83_L 1.021 0.44
25_P 95_I 1.021 0.44
291_V 598_H 1.02 0.43
625_A 661_F 1.019 0.43
372_I 424_G 1.018 0.43
34_M 92_S 1.017 0.43
37_L 282_V 1.017 0.43
606_L 628_L 1.017 0.43
220_I 514_D 1.016 0.43
170_D 209_A 1.016 0.43
48_F 137_N 1.014 0.43
143_K 254_Q 1.01 0.42
194_F 457_P 1.009 0.42
368_G 479_Y 1.007 0.42
128_V 239_A 1.006 0.42
91_A 206_R 1.005 0.42
177_G 184_R 1.005 0.42
119_V 265_G 1.005 0.42
60_L 128_V 1.005 0.42
367_V 373_P 1.005 0.42
226_V 297_A 1.003 0.42
496_I 677_L 1.002 0.42
506_R 535_T 1.001 0.42
137_N 362_S 1.001 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3a5iA20.56211000.617Contact Map0.737
3mixA10.54191000.62Contact Map0.715
3mydA10.51731000.626Contact Map0.65
2x49A10.4741000.637Contact Map0.608
4a5pA30.52021000.646Contact Map0.65
1abvA10.189349.70.986Contact Map0.121
2zy9A20.252942.30.987Contact Map0.269
3dz1A10.203838.70.987Contact Map0.119
2ehhA40.190835.10.988Contact Map0.229
2ojpA20.189334.30.988Contact Map0.226
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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