May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YEAZ - Uncharacterized protein YeaZ
UniProt: P76256 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13512
Length: 231 (227)
Sequences: 1729
Seq/Len: 7.62
YEAZ
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
38_I 77_I 2.826 1.00
221_N 224_W 2.716 1.00
56_I 87_L 2.508 1.00
43_Q 47_T 2.5 1.00
7_D 62_G 2.469 1.00
57_N 87_L 2.407 1.00
26_H 44_D 2.391 1.00
60_A 198_A 2.381 1.00
14_S 191_A 2.297 1.00
82_A 89_M 2.259 1.00
97_T 194_M 2.246 1.00
59_L 78_A 2.209 1.00
2_R 19_N 2.148 1.00
80_G 84_G 2.123 1.00
26_H 48_T 2.109 1.00
17_L 45_I 2.09 1.00
78_A 89_M 2.048 1.00
76_G 80_G 2.038 1.00
25_A 45_I 2.025 1.00
58_A 90_I 1.993 1.00
59_L 87_L 1.815 1.00
2_R 57_N 1.788 1.00
201_M 206_K 1.742 1.00
93_S 141_E 1.733 1.00
45_I 49_S 1.677 1.00
209_A 212_H 1.645 1.00
16_A 191_A 1.618 1.00
124_W 149_V 1.614 1.00
125_A 137_G 1.596 1.00
112_L 126_E 1.591 1.00
53_L 56_I 1.587 1.00
2_R 51_T 1.586 1.00
63_R 91_G 1.582 1.00
75_I 213_A 1.572 1.00
25_A 190_A 1.55 1.00
9_A 62_G 1.524 1.00
117_A 123_Y 1.524 1.00
3_I 58_A 1.521 1.00
18_W 195_L 1.51 0.99
3_I 60_A 1.501 0.99
96_M 127_Y 1.501 0.99
44_D 48_T 1.49 0.99
13_C 41_M 1.478 0.99
59_L 81_L 1.455 0.99
111_V 135_W 1.444 0.99
51_T 55_D 1.4 0.99
141_E 216_V 1.394 0.99
58_A 88_P 1.388 0.99
9_A 94_T 1.374 0.99
60_A 194_M 1.345 0.99
28_E 37_R 1.332 0.98
15_V 42_V 1.327 0.98
39_L 77_I 1.319 0.98
19_N 22_T 1.318 0.98
80_G 83_L 1.312 0.98
93_S 216_V 1.311 0.98
199_C 203_A 1.31 0.98
71_V 75_I 1.308 0.98
121_E 143_V 1.304 0.98
33_E 36_Q 1.295 0.98
61_Y 91_G 1.283 0.98
5_A 198_A 1.282 0.98
145_K 148_I 1.281 0.98
90_I 198_A 1.271 0.98
61_Y 74_G 1.27 0.98
92_V 197_I 1.269 0.98
63_R 213_A 1.266 0.98
21_G 199_C 1.266 0.98
137_G 140_T 1.261 0.98
53_L 81_L 1.256 0.97
116_D 219_R 1.247 0.97
6_I 42_V 1.242 0.97
221_N 226_K 1.238 0.97
42_V 77_I 1.236 0.97
93_S 96_M 1.224 0.97
15_V 45_I 1.222 0.97
17_L 51_T 1.221 0.97
68_F 219_R 1.211 0.97
110_R 113_A 1.211 0.97
52_S 55_D 1.205 0.97
110_R 128_Q 1.199 0.96
96_M 137_G 1.197 0.96
61_Y 75_I 1.185 0.96
63_R 216_V 1.171 0.96
5_A 195_L 1.169 0.96
62_G 94_T 1.167 0.96
121_E 219_R 1.164 0.96
98_M 163_V 1.162 0.95
195_L 198_A 1.159 0.95
17_L 56_I 1.151 0.95
127_Y 137_G 1.149 0.95
7_D 14_S 1.147 0.95
11_E 165_T 1.145 0.95
8_T 74_G 1.134 0.95
104_R 193_D 1.131 0.95
81_L 85_A 1.125 0.94
6_I 74_G 1.119 0.94
17_L 49_S 1.11 0.94
60_A 195_L 1.108 0.94
10_T 115_I 1.107 0.94
96_M 201_M 1.105 0.94
79_Q 213_A 1.104 0.94
91_G 208_V 1.092 0.93
53_L 85_A 1.087 0.93
67_S 79_Q 1.081 0.93
200_Q 204_E 1.067 0.92
58_A 202_F 1.066 0.92
60_A 90_I 1.052 0.91
5_A 60_A 1.051 0.91
114_A 167_W 1.046 0.91
109_T 161_V 1.044 0.91
94_T 115_I 1.043 0.91
119_M 222_V 1.04 0.91
122_V 166_G 1.031 0.90
126_E 139_E 1.028 0.90
119_M 221_N 1.025 0.90
128_Q 158_G 1.025 0.90
128_Q 136_H 1.018 0.89
101_G 193_D 1.017 0.89
6_I 78_A 1.014 0.89
100_Q 135_W 1.005 0.89
98_M 113_A 1.004 0.88
113_A 163_V 1.002 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zeuA20.99571000.143Contact Map0.706
3r6mA40.91771000.215Contact Map0.759
2a6aA20.88311000.225Contact Map0.576
3en9A20.887499.90.602Contact Map0.765
3venA10.861599.90.628Contact Map0.284
3zeuB20.904899.80.634Contact Map0.721
4k25A10.922199.80.637Contact Map0.666
2ivnA10.896199.80.664Contact Map0.652
3enoA20.917799.80.665Contact Map0.662
1iv0A10.3983860.915Contact Map0.518
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 1.0601 seconds.