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DMLA - D-malate dehydrogenase [decarboxylating]
UniProt: P76251 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13507
Length: 361 (351)
Sequences: 3159
Seq/Len: 9.00
DMLA
Paralog alert: 0.66 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: DMLA IDH LEU3
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
179_Q 215_E 4.761 1.00
172_R 212_N 4.335 1.00
171_L 206_V 3.364 1.00
60_D 64_E 3.283 1.00
25_R 353_D 3.189 1.00
22_E 352_A 2.971 1.00
225_I 229_R 2.947 1.00
6_R 39_S 2.87 1.00
331_E 358_I 2.769 1.00
172_R 176_E 2.686 1.00
164_R 168_D 2.65 1.00
309_D 326_L 2.459 1.00
318_F 321_A 2.448 1.00
28_Q 40_F 2.432 1.00
335_H 358_I 2.392 1.00
20_L 300_T 2.344 1.00
56_K 60_D 2.305 1.00
353_D 357_K 2.284 1.00
354_A 357_K 2.276 1.00
22_E 25_R 2.254 1.00
187_T 219_D 2.251 1.00
67_S 100_F 2.166 1.00
34_W 324_G 2.13 1.00
298_I 355_I 2.122 1.00
309_D 323_N 2.062 1.00
24_I 42_Q 2.053 1.00
293_N 349_P 2.052 1.00
9_A 24_I 2.051 1.00
8_A 65_Q 2.038 1.00
168_D 208_A 2.029 1.00
301_I 355_I 2.027 1.00
64_E 68_R 2.006 1.00
17_K 21_P 1.983 1.00
323_N 327_A 1.971 1.00
168_D 205_R 1.965 1.00
209_M 212_N 1.949 1.00
293_N 347_T 1.94 1.00
332_V 358_I 1.923 1.00
44_E 53_H 1.921 1.00
171_L 241_V 1.914 1.00
206_V 218_W 1.914 1.00
50_Y 59_P 1.901 1.00
176_E 213_Y 1.853 1.00
356_C 359_I 1.853 1.00
130_Y 177_L 1.845 1.00
189_A 226_L 1.842 1.00
233_Q 236_R 1.841 1.00
188_S 206_V 1.83 1.00
347_T 350_Q 1.793 1.00
208_A 211_E 1.791 1.00
43_M 65_Q 1.778 1.00
305_A 326_L 1.768 1.00
67_S 99_E 1.745 1.00
185_T 219_D 1.698 1.00
176_E 180_S 1.691 1.00
15_I 295_A 1.673 1.00
302_W 329_I 1.65 1.00
27_L 38_L 1.645 1.00
319_Q 323_N 1.627 1.00
207_E 220_K 1.619 1.00
63_H 99_E 1.618 1.00
164_R 208_A 1.603 1.00
25_R 356_C 1.593 1.00
231_V 253_L 1.591 1.00
160_S 243_S 1.589 1.00
66_L 72_I 1.568 1.00
168_D 172_R 1.567 1.00
8_A 69_F 1.567 1.00
106_L 130_Y 1.565 1.00
327_A 331_E 1.557 1.00
293_N 348_T 1.553 1.00
10_I 45_W 1.551 1.00
352_A 356_C 1.539 1.00
309_D 322_H 1.498 1.00
337_P 354_A 1.495 1.00
183_R 238_D 1.483 1.00
172_R 213_Y 1.483 1.00
95_K 99_E 1.481 1.00
186_L 218_W 1.461 1.00
205_R 208_A 1.452 1.00
201_Y 205_R 1.451 1.00
36_F 318_F 1.449 1.00
171_L 209_M 1.444 0.99
58_M 63_H 1.439 0.99
332_V 354_A 1.431 0.99
41_E 68_R 1.417 0.99
23_G 304_G 1.415 0.99
29_A 356_C 1.413 0.99
44_E 54_H 1.407 0.99
36_F 321_A 1.402 0.99
5_M 318_F 1.393 0.99
184_K 238_D 1.362 0.99
337_P 346_A 1.362 0.99
8_A 66_L 1.355 0.99
176_E 179_Q 1.345 0.99
289_I 295_A 1.328 0.99
22_E 293_N 1.325 0.99
188_S 220_K 1.315 0.99
23_G 300_T 1.313 0.99
106_L 132_V 1.306 0.99
40_F 304_G 1.292 0.99
45_W 96_F 1.287 0.99
221_Q 225_I 1.282 0.98
204_E 208_A 1.271 0.98
132_V 173_Y 1.269 0.98
26_V 359_I 1.264 0.98
131_V 251_S 1.263 0.98
49_E 53_H 1.259 0.98
132_V 177_L 1.258 0.98
8_A 43_M 1.253 0.98
221_Q 229_R 1.247 0.98
351_V 355_I 1.247 0.98
294_I 340_P 1.24 0.98
44_E 50_Y 1.236 0.98
113_P 334_A 1.228 0.98
126_D 235_E 1.227 0.98
30_A 325_I 1.22 0.98
139_E 160_S 1.217 0.98
167_V 171_L 1.209 0.98
298_I 351_V 1.207 0.98
346_A 350_Q 1.206 0.98
41_E 69_F 1.206 0.98
64_E 67_S 1.205 0.98
192_S 203_D 1.2 0.97
172_R 209_M 1.191 0.97
229_R 236_R 1.175 0.97
309_D 319_Q 1.173 0.97
110_R 128_D 1.167 0.97
181_R 238_D 1.167 0.97
110_R 330_E 1.166 0.97
24_I 28_Q 1.163 0.97
175_F 216_I 1.162 0.97
146_R 204_E 1.161 0.97
118_P 123_Q 1.155 0.97
23_G 73_Y 1.154 0.97
131_V 254_G 1.153 0.97
114_G 334_A 1.149 0.96
221_Q 237_F 1.147 0.96
185_T 217_R 1.147 0.96
162_F 243_S 1.145 0.96
227_C 250_L 1.144 0.96
164_R 205_R 1.143 0.96
270_N 275_F 1.143 0.96
350_Q 353_D 1.14 0.96
11_P 42_Q 1.13 0.96
289_I 340_P 1.125 0.96
26_V 325_I 1.121 0.96
59_P 62_W 1.121 0.96
33_R 324_G 1.119 0.96
25_R 352_A 1.118 0.96
74_F 93_L 1.118 0.96
308_L 321_A 1.117 0.96
41_E 65_Q 1.116 0.96
4_T 39_S 1.113 0.96
61_D 64_E 1.111 0.95
324_G 359_I 1.107 0.95
175_F 186_L 1.098 0.95
177_L 181_R 1.098 0.95
139_E 243_S 1.098 0.95
50_Y 54_H 1.097 0.95
104_V 170_I 1.081 0.94
156_V 201_Y 1.08 0.94
168_D 209_M 1.08 0.94
219_D 236_R 1.077 0.94
121_G 125_G 1.074 0.94
293_N 350_Q 1.073 0.94
189_A 223_I 1.07 0.94
135_N 268_N 1.068 0.94
129_F 230_F 1.067 0.94
178_A 186_L 1.061 0.94
6_R 41_E 1.06 0.94
101_D 169_R 1.054 0.93
154_E 164_R 1.041 0.93
31_A 38_L 1.039 0.93
175_F 213_Y 1.03 0.92
175_F 210_A 1.025 0.92
288_D 340_P 1.023 0.92
192_S 222_H 1.021 0.92
346_A 354_A 1.02 0.92
305_A 309_D 1.013 0.92
83_V 88_S 1.012 0.92
227_C 253_L 1.01 0.91
76_A 283_H 1.009 0.91
27_L 304_G 1.006 0.91
73_Y 304_G 1.005 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3flkA40.99721000.054Contact Map0.78
2y3zA10.95291000.073Contact Map0.741
3u1hA20.96681000.078Contact Map0.764
1a05A20.96121000.078Contact Map0.781
3uduA80.95571000.081Contact Map0.841
1cnzA20.97231000.081Contact Map0.821
3r8wA40.96951000.083Contact Map0.765
3vmkA20.97231000.089Contact Map0.766
3ty4A20.95011000.092Contact Map0.725
2e0cA20.95841000.093Contact Map0.814
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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