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OPENSEQ.org
LEUE - Leucine efflux protein
UniProt: P76249 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13505
Length: 212 (207)
Sequences: 4861
Seq/Len: 23.48
LEUE
Paralog alert: 0.74 [within 20: 0.23] - ratio of genomes with paralogs
Cluster includes: EAMB LEUE RHTB RHTC YAHN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
52_I 117_F 5.191 1.00
91_G 201_V 3.291 1.00
191_V 194_S 2.94 1.00
91_G 197_G 2.855 1.00
10_Y 159_T 2.771 1.00
81_Y 85_F 2.626 1.00
35_S 43_G 2.579 1.00
92_S 96_Y 2.561 1.00
77_N 80_R 2.559 1.00
56_V 121_L 2.345 1.00
88_L 204_A 2.342 1.00
121_L 125_L 2.237 1.00
30_F 46_A 2.174 1.00
16_G 137_F 2.062 1.00
88_L 201_V 2.035 1.00
88_L 92_S 1.924 1.00
27_N 50_V 1.889 1.00
164_S 168_L 1.845 1.00
54_D 124_S 1.817 1.00
84_A 208_A 1.795 1.00
95_L 194_S 1.733 1.00
93_K 96_Y 1.719 1.00
198_L 202_G 1.691 1.00
34_N 38_S 1.669 1.00
81_Y 208_A 1.667 1.00
14_L 163_V 1.657 1.00
48_C 117_F 1.642 1.00
27_N 124_S 1.642 1.00
31_V 35_S 1.638 1.00
77_N 81_Y 1.625 1.00
95_L 197_G 1.594 1.00
67_T 71_T 1.583 1.00
81_Y 84_A 1.544 1.00
84_A 204_A 1.54 1.00
74_I 77_N 1.519 1.00
149_T 152_S 1.512 1.00
46_A 120_A 1.497 1.00
190_K 194_S 1.49 1.00
30_F 123_L 1.47 1.00
35_S 172_I 1.435 1.00
74_I 78_I 1.423 1.00
91_G 204_A 1.402 0.99
43_G 47_A 1.385 0.99
134_Y 160_L 1.379 0.99
118_K 122_I 1.371 0.99
59_F 63_A 1.355 0.99
191_V 195_L 1.348 0.99
27_N 54_D 1.343 0.99
28_T 171_L 1.338 0.99
58_M 157_A 1.331 0.99
21_V 163_V 1.302 0.99
179_T 183_R 1.298 0.99
72_T 76_F 1.295 0.99
86_Y 90_L 1.285 0.99
114_G 118_K 1.282 0.99
34_N 46_A 1.282 0.99
76_F 80_R 1.267 0.99
177_F 181_Y 1.254 0.99
27_N 123_L 1.252 0.99
57_L 124_S 1.237 0.98
117_F 121_L 1.236 0.98
143_D 146_A 1.216 0.98
11_W 15_V 1.215 0.98
185_K 188_L 1.208 0.98
115_A 118_K 1.205 0.98
55_A 161_E 1.178 0.98
194_S 198_L 1.174 0.98
16_G 20_I 1.161 0.97
170_F 174_S 1.159 0.97
29_L 33_K 1.159 0.97
175_G 178_V 1.149 0.97
54_D 130_A 1.14 0.97
177_F 180_Q 1.131 0.97
34_N 119_R 1.13 0.97
13_Y 17_A 1.124 0.97
32_L 175_G 1.124 0.97
126_T 135_V 1.112 0.96
47_A 172_I 1.109 0.96
201_V 204_A 1.103 0.96
15_V 19_F 1.099 0.96
40_M 173_I 1.095 0.96
52_I 121_L 1.095 0.96
24_P 129_K 1.086 0.96
192_G 196_I 1.085 0.96
42_G 116_I 1.08 0.95
9_N 12_T 1.076 0.95
89_Y 93_K 1.07 0.95
53_G 121_L 1.059 0.95
167_Y 171_L 1.057 0.95
169_S 173_I 1.054 0.95
28_T 168_L 1.042 0.94
27_N 164_S 1.041 0.94
86_Y 89_Y 1.035 0.94
69_I 72_T 1.034 0.94
31_V 50_V 1.031 0.94
154_F 157_A 1.024 0.93
10_Y 14_L 1.019 0.93
95_L 201_V 1.019 0.93
162_L 166_C 1.013 0.93
52_I 56_V 1.011 0.93
78_I 81_Y 1.011 0.93
14_L 18_I 1.01 0.93
17_A 21_V 1.007 0.93
56_V 125_L 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
2m67A10.36792.80.953Contact Map0.33
2wswA10.47172.30.955Contact Map0.259
3j1zP20.8162.10.956Contact Map0.343
2cfqA10.90091.90.957Contact Map0.22
2h3oA10.27361.80.958Contact Map0.154
2jo1A10.1841.20.962Contact Map0.639
3wdoA10.45751.10.962Contact Map0.452
4kppA20.46231.10.962Contact Map0.55
3o7qA10.910410.963Contact Map0.274
4lepA20.471710.963Contact Map0.498
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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