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OPENSEQ.org
VES - Protein ves
UniProt: P76214 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13994
Length: 191 (181)
Sequences: 210
Seq/Len: 1.16
VES
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
56_E 112_L 2.57 1.00
66_E 97_L 2.104 0.98
55_M 109_M 2.024 0.97
109_M 112_L 1.966 0.96
110_T 117_A 1.948 0.96
55_M 112_L 1.729 0.91
42_S 104_M 1.682 0.89
108_I 117_A 1.675 0.89
65_G 99_A 1.671 0.89
82_F 121_I 1.664 0.89
34_F 105_D 1.623 0.87
66_E 100_G 1.607 0.86
56_E 109_M 1.605 0.86
59_V 85_F 1.573 0.85
106_F 157_C 1.553 0.84
61_L 77_H 1.545 0.83
18_A 47_G 1.506 0.81
40_I 106_F 1.468 0.78
62_L 174_L 1.448 0.77
25_C 36_W 1.41 0.74
59_V 105_D 1.403 0.74
79_L 105_D 1.401 0.74
108_I 119_V 1.375 0.72
103_S 106_F 1.358 0.70
24_I 53_P 1.321 0.67
97_L 100_G 1.321 0.67
22_R 61_L 1.314 0.67
50_S 54_G 1.255 0.62
13_L 145_L 1.242 0.60
95_A 175_L 1.238 0.60
67_M 103_S 1.236 0.60
28_P 34_F 1.236 0.60
46_N 55_M 1.226 0.59
38_A 108_I 1.223 0.59
144_Q 169_Q 1.219 0.58
47_G 64_G 1.214 0.58
35_Y 115_C 1.212 0.58
103_S 154_Q 1.208 0.57
64_G 105_D 1.206 0.57
134_G 158_W 1.202 0.57
18_A 36_W 1.2 0.56
15_R 176_F 1.198 0.56
24_I 135_V 1.198 0.56
4_F 155_G 1.189 0.55
59_V 138_V 1.183 0.55
55_M 58_I 1.179 0.54
22_R 175_L 1.166 0.53
108_I 175_L 1.164 0.53
61_L 143_W 1.159 0.53
28_P 111_R 1.158 0.52
13_L 140_N 1.155 0.52
88_A 94_K 1.153 0.52
68_L 76_N 1.152 0.52
89_A 117_A 1.149 0.52
70_E 179_I 1.144 0.51
89_A 175_L 1.144 0.51
62_L 150_L 1.142 0.51
53_P 83_Q 1.142 0.51
15_R 47_G 1.132 0.50
72_A 118_K 1.126 0.49
150_L 154_Q 1.117 0.48
24_I 96_K 1.117 0.48
5_D 8_K 1.117 0.48
45_A 88_A 1.093 0.46
60_T 175_L 1.087 0.46
68_L 98_T 1.085 0.45
9_M 93_V 1.085 0.45
43_I 138_V 1.083 0.45
25_C 48_E 1.082 0.45
177_S 182_L 1.078 0.45
4_F 43_I 1.073 0.44
33_D 38_A 1.069 0.44
23_E 105_D 1.067 0.44
143_W 158_W 1.065 0.43
58_I 117_A 1.065 0.43
106_F 135_V 1.059 0.43
34_F 79_L 1.053 0.42
23_E 41_A 1.05 0.42
158_W 167_L 1.047 0.42
20_E 38_A 1.047 0.42
15_R 26_T 1.046 0.42
34_F 59_V 1.046 0.42
6_M 40_I 1.042 0.41
86_A 116_K 1.041 0.41
62_L 105_D 1.032 0.40
55_M 111_R 1.024 0.40
67_M 139_I 1.023 0.40
22_R 95_A 1.022 0.39
18_A 42_S 1.021 0.39
10_S 168_L 1.02 0.39
58_I 110_T 1.013 0.39
59_V 89_A 1.007 0.38
24_I 35_Y 1.006 0.38
38_A 144_Q 1.005 0.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3esgA20.94761000.228Contact Map0.289
1yllA40.95291000.244Contact Map0.33
3rnsA10.884885.80.924Contact Map0.233
1sefA10.968672.90.933Contact Map0.222
4e2qA160.921561.50.938Contact Map0.271
3fjsA40.55549.90.942Contact Map0.458
3lwcA10.586448.90.943Contact Map0.343
4axoA20.617847.40.943Contact Map0.324
2pytA20.570736.70.947Contact Map0.292
2q1zB20.4974310.949Contact Map0.288
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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