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YNFH - Anaerobic dimethyl sulfoxide reductase chain YnfH
UniProt: P76173 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13846
Length: 284 (281)
Sequences: 364
Seq/Len: 1.30
YNFH
Paralog alert: 0.71 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: DMSC YNFH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
96_V 124_L 3.107 1.00
82_G 85_N 2.036 0.98
11_V 270_L 1.977 0.97
89_A 131_M 1.953 0.97
21_V 125_G 1.926 0.96
129_V 157_V 1.806 0.94
89_A 92_I 1.805 0.94
70_R 73_N 1.769 0.94
21_V 87_I 1.732 0.93
12_I 16_L 1.666 0.91
15_V 264_E 1.636 0.89
9_P 18_Q 1.602 0.88
20_V 93_F 1.584 0.87
67_S 70_R 1.558 0.86
7_E 14_T 1.53 0.85
70_R 90_G 1.515 0.84
119_L 190_I 1.497 0.83
142_P 267_G 1.487 0.82
90_G 128_F 1.457 0.81
155_L 192_C 1.425 0.79
71_A 83_L 1.421 0.78
18_Q 153_F 1.407 0.77
71_A 84_S 1.405 0.77
123_A 261_L 1.399 0.77
7_E 18_Q 1.398 0.77
128_F 140_T 1.396 0.77
11_V 155_L 1.365 0.74
92_I 116_L 1.361 0.74
160_S 164_L 1.356 0.74
75_L 91_S 1.344 0.73
18_Q 267_G 1.335 0.72
261_L 265_M 1.33 0.72
203_L 211_Q 1.329 0.71
59_I 106_I 1.312 0.70
66_G 71_A 1.31 0.70
156_T 264_E 1.31 0.70
1_M 4_G 1.303 0.69
23_A 53_L 1.302 0.69
126_V 229_V 1.271 0.66
64_H 86_E 1.27 0.66
92_I 219_D 1.269 0.66
236_G 265_M 1.268 0.66
8_W 181_F 1.268 0.66
89_A 127_I 1.267 0.66
93_F 125_G 1.263 0.66
61_S 71_A 1.262 0.66
12_I 190_I 1.261 0.66
27_S 164_L 1.26 0.66
88_A 93_F 1.258 0.65
15_V 87_I 1.255 0.65
74_S 208_S 1.246 0.64
264_E 267_G 1.243 0.64
75_L 125_G 1.236 0.63
21_V 157_V 1.231 0.63
21_V 260_I 1.228 0.63
61_S 83_L 1.223 0.62
126_V 258_I 1.222 0.62
267_G 272_Y 1.216 0.61
85_N 272_Y 1.213 0.61
66_G 149_T 1.205 0.60
99_L 127_I 1.204 0.60
48_F 168_I 1.202 0.60
89_A 99_L 1.2 0.60
98_G 102_L 1.2 0.60
122_M 126_V 1.196 0.60
147_G 186_V 1.188 0.59
62_V 91_S 1.186 0.59
233_A 240_C 1.181 0.58
95_A 141_V 1.167 0.57
73_N 141_V 1.163 0.56
18_Q 87_I 1.161 0.56
123_A 229_V 1.161 0.56
50_L 67_S 1.158 0.56
7_E 13_F 1.154 0.55
66_G 84_S 1.153 0.55
82_G 135_V 1.152 0.55
79_G 272_Y 1.15 0.55
149_T 271_F 1.146 0.55
60_A 65_L 1.145 0.55
12_I 60_A 1.143 0.54
223_L 234_G 1.142 0.54
259_L 265_M 1.138 0.54
227_R 270_L 1.136 0.54
16_L 205_S 1.13 0.53
16_L 57_G 1.128 0.53
197_V 258_I 1.127 0.53
18_Q 21_V 1.127 0.53
275_H 279_G 1.126 0.53
70_R 138_I 1.124 0.52
158_L 248_P 1.121 0.52
119_L 123_A 1.12 0.52
74_S 82_G 1.117 0.52
165_A 191_A 1.116 0.52
13_F 141_V 1.116 0.52
18_Q 22_G 1.112 0.51
258_I 262_G 1.11 0.51
124_L 127_I 1.105 0.51
276_M 279_G 1.103 0.50
121_S 125_G 1.101 0.50
79_G 85_N 1.1 0.50
54_M 94_F 1.1 0.50
87_I 91_S 1.1 0.50
123_A 246_R 1.099 0.50
65_L 256_G 1.094 0.50
3_N 255_L 1.091 0.49
236_G 258_I 1.09 0.49
25_I 123_A 1.081 0.48
18_Q 132_M 1.08 0.48
10_L 13_F 1.078 0.48
111_Q 123_A 1.072 0.47
169_L 227_R 1.068 0.47
79_G 215_A 1.067 0.47
190_I 253_L 1.061 0.46
156_T 267_G 1.059 0.46
104_A 158_L 1.053 0.45
130_W 146_N 1.049 0.45
186_V 236_G 1.048 0.45
19_C 160_S 1.046 0.45
13_F 17_G 1.045 0.45
85_N 135_V 1.043 0.44
73_N 85_N 1.04 0.44
112_A 180_P 1.039 0.44
197_V 239_L 1.036 0.44
12_I 146_N 1.036 0.44
44_V 117_W 1.033 0.43
68_P 83_L 1.033 0.43
7_E 10_L 1.033 0.43
250_V 262_G 1.03 0.43
55_G 256_G 1.03 0.43
132_M 230_L 1.03 0.43
60_A 123_A 1.029 0.43
58_F 90_G 1.019 0.42
219_D 232_C 1.017 0.42
225_V 234_G 1.016 0.42
73_N 196_I 1.014 0.42
29_I 187_L 1.012 0.41
71_A 87_I 1.011 0.41
19_C 53_L 1.004 0.41
92_I 266_I 1.004 0.41
13_F 90_G 1.004 0.41
233_A 255_L 1.003 0.41
111_Q 233_A 1.002 0.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vpzC20.845199.50.763Contact Map0.23
4gc0A10.63383.10.968Contact Map0.129
3n0rA10.21130.90.977Contact Map0.051
4h44F10.08450.90.977Contact Map0.16
2kv5A10.11620.70.979Contact Map0.009
2ls4A10.08450.70.979Contact Map0.359
3hzhA10.18660.60.979Contact Map0.089
2ayxA10.19720.60.98Contact Map0.039
1o9aB10.04230.60.98Contact Map0
4b19A10.10560.50.981Contact Map0.184
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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