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OPENSEQ.org
LSRF - Uncharacterized aldolase LsrF
UniProt: P76143 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13810
Length: 291 (257)
Sequences: 584
Seq/Len: 2.27
LSRF
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
242_A 247_A 3.046 1.00
240_W 244_D 2.826 1.00
52_V 273_V 2.801 1.00
252_M 269_V 2.737 1.00
105_V 171_M 2.614 1.00
240_W 279_A 2.564 1.00
237_E 241_Q 2.412 1.00
243_I 272_V 2.375 1.00
163_G 170_T 2.323 1.00
123_V 156_I 2.299 1.00
137_A 169_P 2.23 1.00
233_R 280_D 2.22 1.00
89_R 129_D 2.166 1.00
201_I 223_V 2.102 1.00
128_D 162_A 2.036 0.99
84_V 105_V 1.98 0.99
233_R 279_A 1.967 0.99
87_C 133_L 1.909 0.99
206_Y 211_F 1.885 0.99
271_A 285_L 1.87 0.99
174_T 194_A 1.86 0.99
271_A 275_H 1.855 0.99
50_K 248_S 1.83 0.98
39_R 169_P 1.79 0.98
140_A 156_I 1.765 0.98
271_A 277_E 1.736 0.97
202_I 218_C 1.657 0.96
131_V 168_M 1.62 0.96
129_D 161_D 1.573 0.95
108_A 159_L 1.569 0.95
188_S 213_R 1.565 0.95
126_S 161_D 1.553 0.94
233_R 237_E 1.552 0.94
125_L 129_D 1.552 0.94
43_I 84_V 1.542 0.94
195_A 219_P 1.538 0.94
139_A 173_V 1.516 0.93
182_R 208_E 1.482 0.92
89_R 125_L 1.48 0.92
192_R 196_E 1.438 0.91
278_T 281_R 1.437 0.91
160_V 170_T 1.432 0.90
54_L 256_I 1.429 0.90
231_P 234_E 1.426 0.90
107_R 141_Q 1.42 0.90
107_R 173_V 1.41 0.89
256_I 269_V 1.401 0.89
52_V 250_V 1.348 0.86
107_R 143_Y 1.347 0.86
207_V 210_G 1.34 0.86
50_K 276_N 1.34 0.86
70_R 73_I 1.314 0.85
60_Y 142_V 1.311 0.84
39_R 42_R 1.295 0.83
184_Q 188_S 1.291 0.83
236_L 268_A 1.289 0.83
128_D 166_V 1.287 0.83
83_D 274_H 1.28 0.82
146_S 176_V 1.276 0.82
141_Q 173_V 1.274 0.82
107_R 189_L 1.27 0.82
146_S 152_S 1.266 0.81
156_I 172_A 1.247 0.80
207_V 211_F 1.243 0.80
143_Y 189_L 1.238 0.79
215_V 245_Q 1.235 0.79
187_F 207_V 1.231 0.79
38_S 42_R 1.226 0.78
147_E 178_K 1.212 0.77
235_A 265_M 1.211 0.77
72_D 76_A 1.2 0.76
107_R 139_A 1.199 0.76
121_E 173_V 1.198 0.76
109_S 173_V 1.178 0.74
108_A 127_M 1.172 0.74
143_Y 173_V 1.161 0.73
264_A 268_A 1.161 0.73
109_S 141_Q 1.159 0.73
162_A 165_K 1.145 0.71
139_A 143_Y 1.144 0.71
121_E 139_A 1.143 0.71
121_E 141_Q 1.141 0.71
94_S 219_P 1.137 0.71
123_V 159_L 1.134 0.70
132_R 165_K 1.133 0.70
42_R 136_C 1.132 0.70
268_A 282_A 1.132 0.70
40_L 202_I 1.13 0.70
148_Y 152_S 1.127 0.70
93_R 198_G 1.125 0.69
61_F 107_R 1.123 0.69
109_S 142_V 1.099 0.67
112_N 149_E 1.092 0.66
213_R 216_A 1.088 0.66
117_E 204_T 1.083 0.65
229_K 255_N 1.08 0.65
131_V 162_A 1.073 0.64
182_R 228_K 1.068 0.64
220_V 236_L 1.059 0.63
272_V 279_A 1.059 0.63
50_K 243_I 1.053 0.62
121_E 143_Y 1.05 0.62
107_R 121_E 1.045 0.61
127_M 159_L 1.035 0.60
283_Y 287_L 1.029 0.59
206_Y 242_A 1.025 0.59
61_F 139_A 1.022 0.59
84_V 171_M 1.02 0.58
161_D 165_K 1.018 0.58
141_Q 189_L 1.016 0.58
125_L 161_D 1.013 0.58
120_N 151_Q 1.005 0.57
235_A 239_C 1.005 0.57
166_V 170_T 1.004 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fokA100.91411000.403Contact Map0.375
3glcA2011000.418Contact Map0.645
3iv3A10.88661000.469Contact Map0.463
4mozA50.95191000.476Contact Map0.728
1to3A10.85911000.505Contact Map0.404
1w8sA100.85911000.592Contact Map0.68
2qjgA200.91071000.62Contact Map0.742
3oa3A20.90031000.699Contact Map0.207
3r12A20.81791000.705Contact Map0.224
3ndoA20.7321000.714Contact Map0.257
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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