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OPENSEQ.org
YDET - Putative uncharacterized protein ydet
UniProt: P76137 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13802
Length: 382 (374)
Sequences: 1300
Seq/Len: 3.48
YDET
Paralog alert: 0.76 [within 20: 0.05] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
223_V 254_A 4 1.00
185_N 200_G 3.754 1.00
187_G 198_Y 3.175 1.00
215_G 250_I 3.015 1.00
213_T 244_D 2.833 1.00
345_G 363_Y 2.822 1.00
205_I 214_F 2.811 1.00
302_V 341_L 2.748 1.00
319_V 347_L 2.69 1.00
319_V 336_V 2.636 1.00
317_A 349_V 2.564 1.00
72_V 79_T 2.493 1.00
208_H 213_T 2.47 1.00
226_K 293_T 2.454 1.00
224_L 248_Y 2.351 1.00
48_F 69_G 2.286 1.00
45_G 70_L 2.269 1.00
207_A 212_I 2.213 1.00
222_M 289_I 2.184 1.00
154_S 174_S 2.165 1.00
156_Q 172_Y 2.148 1.00
125_Y 137_N 2.103 1.00
306_L 361_V 2.051 1.00
300_G 343_Q 2.045 1.00
204_G 218_L 1.946 1.00
208_H 248_Y 1.926 1.00
220_D 286_H 1.887 1.00
210_D 226_K 1.869 1.00
260_N 284_P 1.846 0.99
347_L 361_V 1.828 0.99
205_I 212_I 1.824 0.99
226_K 291_R 1.799 0.99
82_N 99_A 1.788 0.99
319_V 349_V 1.765 0.99
184_T 201_M 1.762 0.99
227_A 230_A 1.756 0.99
272_N 300_G 1.75 0.99
182_G 201_M 1.739 0.99
361_V 379_A 1.688 0.99
32_Q 54_Q 1.672 0.99
209_A 291_R 1.669 0.99
218_L 222_M 1.666 0.99
314_P 317_A 1.642 0.98
204_G 222_M 1.636 0.98
208_H 211_G 1.636 0.98
284_P 290_A 1.633 0.98
313_V 349_V 1.632 0.98
306_L 349_V 1.617 0.98
223_V 262_V 1.602 0.98
299_G 340_G 1.599 0.98
227_A 296_A 1.596 0.98
204_G 215_G 1.586 0.98
306_L 336_V 1.581 0.98
259_E 281_T 1.561 0.98
46_T 336_V 1.545 0.97
249_A 252_P 1.543 0.97
210_D 291_R 1.532 0.97
235_I 251_L 1.526 0.97
124_S 140_G 1.523 0.97
308_Y 313_V 1.507 0.97
204_G 250_I 1.468 0.96
206_I 289_I 1.467 0.96
306_L 330_V 1.456 0.96
49_F 68_F 1.455 0.96
179_G 182_G 1.45 0.96
41_L 45_G 1.437 0.96
227_A 233_V 1.431 0.95
230_A 296_A 1.431 0.95
285_T 288_A 1.413 0.95
206_I 224_L 1.402 0.95
130_D 133_G 1.39 0.94
30_R 57_W 1.38 0.94
317_A 351_W 1.376 0.94
346_Q 360_I 1.373 0.94
233_V 243_T 1.372 0.94
314_P 351_W 1.371 0.94
31_G 55_S 1.357 0.93
85_Y 96_H 1.353 0.93
206_I 222_M 1.34 0.93
213_T 224_L 1.338 0.93
71_N 80_S 1.322 0.92
275_L 278_T 1.31 0.92
53_R 62_S 1.299 0.91
145_L 153_Y 1.286 0.91
176_N 183_N 1.281 0.91
208_H 224_L 1.271 0.90
321_H 325_K 1.262 0.90
53_R 64_Q 1.253 0.89
6_V 10_T 1.247 0.89
218_L 289_I 1.246 0.89
6_V 9_P 1.245 0.89
213_T 246_R 1.238 0.88
207_A 224_L 1.238 0.88
287_G 315_F 1.235 0.88
318_I 326_N 1.216 0.87
226_K 248_Y 1.216 0.87
40_Q 130_D 1.212 0.87
80_S 101_T 1.212 0.87
36_S 50_S 1.207 0.87
178_R 216_Q 1.2 0.86
210_D 214_F 1.197 0.86
130_D 134_G 1.188 0.86
352_G 355_K 1.183 0.85
346_Q 362_E 1.183 0.85
47_T 124_S 1.182 0.85
308_Y 311_K 1.175 0.85
8_P 12_D 1.175 0.85
304_M 338_L 1.167 0.84
228_P 246_R 1.166 0.84
179_G 184_T 1.163 0.84
299_G 337_Y 1.154 0.83
41_L 70_L 1.15 0.83
344_S 364_K 1.147 0.83
301_K 339_T 1.146 0.83
129_N 134_G 1.123 0.81
304_M 377_Q 1.117 0.80
36_S 101_T 1.109 0.80
190_R 195_S 1.109 0.80
21_D 90_W 1.108 0.80
216_Q 240_G 1.106 0.79
216_Q 241_I 1.101 0.79
74_F 79_T 1.098 0.79
6_V 363_Y 1.095 0.79
38_S 48_F 1.083 0.77
55_S 62_S 1.082 0.77
280_V 292_A 1.081 0.77
42_G 45_G 1.08 0.77
86_S 273_V 1.074 0.77
224_L 291_R 1.072 0.76
352_G 357_S 1.064 0.76
50_S 67_S 1.063 0.76
331_A 335_Q 1.062 0.76
228_P 243_T 1.061 0.75
219_G 256_E 1.054 0.75
34_Q 54_Q 1.053 0.75
105_P 287_G 1.052 0.75
332_E 339_T 1.05 0.74
158_G 170_S 1.049 0.74
81_L 354_D 1.045 0.74
251_L 262_V 1.044 0.74
300_G 375_N 1.044 0.74
328_S 339_T 1.043 0.74
313_V 317_A 1.042 0.74
151_L 177_Y 1.039 0.73
125_Y 139_S 1.039 0.73
155_V 225_V 1.036 0.73
225_V 349_V 1.036 0.73
243_T 301_K 1.033 0.73
349_V 361_V 1.032 0.73
221_T 256_E 1.032 0.73
5_T 8_P 1.031 0.72
34_Q 69_G 1.031 0.72
276_D 295_N 1.028 0.72
244_D 250_I 1.026 0.72
41_L 44_Y 1.025 0.72
223_V 290_A 1.024 0.72
52_S 153_Y 1.023 0.72
300_G 366_P 1.022 0.71
204_G 207_A 1.014 0.71
39_Q 45_G 1.014 0.71
234_K 268_S 1.007 0.70
79_T 100_F 1.005 0.70
213_T 248_Y 1.004 0.70
225_V 235_I 1 0.69
148_D 235_I 1 0.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rfzB20.97641000.119Contact Map0.739
3fipA20.48171000.674Contact Map0.727
2xetA20.219999.80.763Contact Map0.793
3l48A50.219999.80.78Contact Map0.906
3e8vA10.193720.40.965Contact Map0.421
4koqA10.222517.50.966Contact Map0.18
4e1sA10.35086.70.972Contact Map0.305
2p6hA20.30636.40.972Contact Map0.027
2y0lA10.280150.974Contact Map0.522
4fspA10.28014.70.974Contact Map0.439
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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