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OPENSEQ.org
YDEM - Anaerobic sulfatase-maturating enzyme homolog YdeM
UniProt: P76134 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13795
Length: 385 (358)
Sequences: 2434
Seq/Len: 6.80
YDEM
Paralog alert: 0.56 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: ASLB MOAA YDEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
121_Q 138_A 7.089 1.00
38_T 292_N 4.133 1.00
125_D 135_G 3.794 1.00
274_D 290_N 3.435 1.00
278_C 328_C 3.321 1.00
14_L 96_I 3.233 1.00
100_N 146_R 3.17 1.00
13_N 94_N 2.942 1.00
35_D 38_T 2.928 1.00
104_A 150_Y 2.92 1.00
100_N 149_S 2.807 1.00
41_E 45_Q 2.672 1.00
274_D 287_K 2.595 1.00
173_H 177_S 2.575 1.00
36_D 73_K 2.5 1.00
137_F 174_F 2.465 1.00
120_P 123_L 2.388 1.00
121_Q 125_D 2.378 1.00
145_E 178_I 2.377 1.00
118_D 128_R 2.376 1.00
263_C 278_C 2.332 1.00
167_Y 170_E 2.327 1.00
145_E 149_S 2.296 1.00
104_A 108_E 2.17 1.00
98_L 103_C 2.155 1.00
120_P 167_Y 2.148 1.00
295_E 298_T 2.086 1.00
294_S 298_T 2.059 1.00
162_N 217_A 2.05 1.00
99_N 102_W 2.011 1.00
95_G 115_I 1.998 1.00
141_I 178_I 1.996 1.00
270_E 274_D 1.986 1.00
290_N 293_K 1.963 1.00
103_C 146_R 1.958 1.00
124_H 136_T 1.935 1.00
79_Q 109_H 1.931 1.00
139_K 142_A 1.93 1.00
115_I 143_A 1.918 1.00
115_I 144_I 1.896 1.00
44_K 85_K 1.876 1.00
34_M 38_T 1.864 1.00
100_N 150_Y 1.859 1.00
13_N 97_L 1.849 1.00
263_C 328_C 1.829 1.00
92_Q 114_G 1.816 1.00
275_I 299_M 1.79 1.00
44_K 77_Y 1.768 1.00
44_K 81_Y 1.726 1.00
58_W 89_N 1.711 1.00
123_L 167_Y 1.693 1.00
312_P 338_N 1.693 1.00
113_V 147_L 1.691 1.00
173_H 228_Q 1.677 1.00
130_S 134_N 1.675 1.00
156_T 175_L 1.671 1.00
117_I 156_T 1.67 1.00
15_K 131_N 1.656 1.00
14_L 136_T 1.65 1.00
98_L 106_L 1.628 1.00
105_F 109_H 1.616 1.00
144_I 154_F 1.606 1.00
126_R 163_V 1.602 1.00
119_G 137_F 1.598 1.00
40_K 77_Y 1.596 1.00
140_V 143_A 1.559 0.99
169_L 224_T 1.554 0.99
170_E 173_H 1.528 0.99
96_I 143_A 1.519 0.99
145_E 148_K 1.509 0.99
174_F 178_I 1.464 0.99
276_Y 287_K 1.462 0.99
130_S 139_K 1.459 0.99
17_D 129_R 1.442 0.99
13_N 62_E 1.439 0.99
16_C 19_C 1.432 0.99
41_E 44_K 1.429 0.99
12_C 19_C 1.422 0.99
156_T 180_S 1.41 0.99
40_K 72_R 1.407 0.99
38_T 41_E 1.406 0.99
11_Q 33_W 1.404 0.99
40_K 73_K 1.391 0.99
39_L 74_V 1.39 0.99
124_H 135_G 1.378 0.98
146_R 149_S 1.362 0.98
43_I 85_K 1.358 0.98
64_T 97_L 1.356 0.98
43_I 56_F 1.346 0.98
12_C 16_C 1.322 0.98
107_K 150_Y 1.322 0.98
17_D 126_R 1.321 0.98
121_Q 137_F 1.321 0.98
257_C 263_C 1.312 0.98
142_A 146_R 1.304 0.98
147_L 152_V 1.3 0.98
62_E 93_T 1.284 0.97
46_Y 56_F 1.279 0.97
20_F 59_Q 1.273 0.97
223_S 227_M 1.267 0.97
143_A 146_R 1.266 0.97
116_S 159_V 1.256 0.97
315_C 318_C 1.252 0.97
78_Q 89_N 1.236 0.96
72_R 108_E 1.232 0.96
71_F 102_W 1.232 0.96
103_C 143_A 1.23 0.96
127_Y 161_N 1.229 0.96
119_G 128_R 1.227 0.96
75_I 105_F 1.226 0.96
142_A 145_E 1.22 0.96
138_A 142_A 1.22 0.96
69_D 73_K 1.219 0.96
120_P 170_E 1.211 0.96
103_C 107_K 1.21 0.96
10_F 271_S 1.201 0.96
157_L 279_D 1.201 0.96
148_K 179_G 1.198 0.95
172_Y 176_K 1.198 0.95
107_K 151_Q 1.196 0.95
159_V 188_L 1.19 0.95
104_A 107_K 1.185 0.95
139_K 143_A 1.178 0.95
36_D 40_K 1.175 0.95
91_L 113_V 1.172 0.95
146_R 150_Y 1.17 0.95
94_N 97_L 1.168 0.95
97_L 143_A 1.159 0.94
315_C 324_C 1.151 0.94
39_L 73_K 1.141 0.94
68_L 102_W 1.134 0.93
103_C 150_Y 1.131 0.93
257_C 278_C 1.128 0.93
166_H 220_K 1.126 0.93
257_C 328_C 1.124 0.93
158_T 183_M 1.115 0.93
138_A 141_I 1.112 0.93
37_S 41_E 1.102 0.92
73_K 76_H 1.097 0.92
315_C 345_C 1.095 0.92
168_P 224_T 1.091 0.92
40_K 81_Y 1.089 0.91
125_D 136_T 1.086 0.91
40_K 44_K 1.085 0.91
318_C 324_C 1.068 0.90
14_L 130_S 1.063 0.90
157_L 186_I 1.061 0.90
141_I 174_F 1.06 0.90
68_L 105_F 1.059 0.90
175_L 180_S 1.056 0.90
119_G 123_L 1.053 0.90
128_R 133_G 1.052 0.89
59_Q 92_Q 1.052 0.89
286_Y 333_I 1.05 0.89
107_K 152_V 1.049 0.89
319_A 353_S 1.043 0.89
318_C 345_C 1.043 0.89
100_N 104_A 1.036 0.89
114_G 157_L 1.031 0.88
320_Y 353_S 1.03 0.88
76_H 105_F 1.025 0.88
34_M 39_L 1.025 0.88
112_L 155_N 1.023 0.88
313_A 316_Q 1.021 0.88
72_R 105_F 1.017 0.87
314_K 342_S 1.012 0.87
62_E 94_N 1.011 0.87
75_I 109_H 1.009 0.87
147_L 154_F 1.006 0.86
91_L 106_L 1.004 0.86
144_I 180_S 1.004 0.86
64_T 143_A 1.002 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4k36A20.97141000.268Contact Map0.723
1tv8A20.79481000.586Contact Map0.637
4m7tA10.60781000.617Contact Map0.546
3c8fA10.56361000.671Contact Map0.562
2yx0A10.62699.90.705Contact Map0.555
2z2uA10.597499.90.714Contact Map0.621
3rfaA20.680599.90.719Contact Map0.481
2qgqA80.724799.90.723Contact Map0.63
2a5hA40.698799.90.735Contact Map0.51
4jc0A20.724799.90.735Contact Map0.545
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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