May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YNCE - Uncharacterized protein YncE
UniProt: P76116 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13775
Length: 353 (290)
Sequences: 14523
Seq/Len: 50.08
YNCE
Paralog alert: 0.62 [within 20: 0.30] - ratio of genomes with paralogs
Cluster includes: 6PGL YNCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
166_I 201_T 2.686 1.00
183_T 201_T 2.341 1.00
208_L 247_I 2.332 1.00
113_V 157_I 2.328 1.00
189_G 202_T 2.306 1.00
313_P 330_V 2.298 1.00
145_E 158_S 2.246 1.00
56_W 96_I 2.215 1.00
255_V 288_V 2.191 1.00
139_R 157_I 2.121 1.00
209_I 221_R 2.111 1.00
318_S 331_S 2.107 1.00
167_W 179_A 2.094 1.00
296_V 330_V 2.078 1.00
71_V 106_G 2.072 1.00
45_E 58_A 2.013 1.00
235_N 248_T 2.012 1.00
200_Y 238_L 1.964 1.00
300_D 303_S 1.941 1.00
272_P 288_V 1.94 1.00
256_L 268_K 1.892 1.00
56_W 103_L 1.878 1.00
156_Y 192_L 1.869 1.00
156_Y 199_L 1.851 1.00
246_F 286_A 1.845 1.00
114_T 126_R 1.844 1.00
290_H 293_A 1.834 1.00
57_L 74_L 1.818 1.00
247_I 258_V 1.809 1.00
297_S 309_T 1.79 1.00
88_D 106_G 1.779 1.00
114_T 123_V 1.74 1.00
200_Y 210_T 1.732 1.00
200_Y 245_A 1.723 1.00
93_G 107_N 1.709 1.00
72_Y 84_A 1.706 1.00
276_A 289_T 1.685 1.00
147_V 191_A 1.666 1.00
75_D 78_T 1.663 1.00
287_Y 321_L 1.654 1.00
156_Y 168_V 1.643 1.00
287_Y 328_L 1.634 1.00
56_W 73_R 1.632 1.00
202_T 233_F 1.606 1.00
72_Y 81_V 1.589 1.00
117_D 120_T 1.587 1.00
47_A 95_T 1.58 1.00
246_F 279_F 1.569 1.00
240_T 283_R 1.562 1.00
201_T 211_I 1.561 1.00
59_T 68_G 1.547 1.00
249_D 252_A 1.534 1.00
157_I 169_V 1.529 1.00
287_Y 298_V 1.524 1.00
212_D 215_D 1.519 1.00
200_Y 236_I 1.512 1.00
297_S 306_V 1.505 1.00
156_Y 190_L 1.492 1.00
48_Y 329_Y 1.486 1.00
191_A 237_S 1.484 1.00
259_D 262_N 1.482 1.00
188_T 204_A 1.48 1.00
248_T 274_S 1.478 1.00
256_L 265_I 1.475 1.00
149_D 192_L 1.471 1.00
288_V 299_I 1.47 1.00
225_L 247_I 1.465 1.00
167_W 176_L 1.439 1.00
56_W 94_A 1.426 1.00
39_V 57_L 1.419 1.00
95_T 147_V 1.396 0.99
246_F 277_V 1.388 0.99
271_A 299_I 1.383 0.99
278_L 319_L 1.374 0.99
159_G 163_E 1.372 0.99
278_L 320_A 1.337 0.99
104_W 155_V 1.33 0.99
97_N 148_A 1.328 0.99
50_Q 100_T 1.325 0.99
170_D 173_N 1.319 0.99
237_S 277_V 1.306 0.99
150_D 196_G 1.303 0.99
280_N 321_L 1.297 0.99
248_T 277_V 1.294 0.99
203_N 207_E 1.278 0.99
58_A 91_P 1.275 0.99
313_P 332_V 1.273 0.99
237_S 278_L 1.27 0.99
158_S 187_S 1.266 0.99
139_R 143_P 1.26 0.99
81_V 84_A 1.259 0.99
108_T 112_A 1.254 0.99
105_F 155_V 1.248 0.99
97_N 101_Q 1.246 0.98
246_F 257_V 1.236 0.98
183_T 203_N 1.226 0.98
290_H 295_K 1.223 0.98
104_W 115_A 1.221 0.98
258_V 265_I 1.219 0.98
104_W 148_A 1.212 0.98
139_R 163_E 1.208 0.98
183_T 205_D 1.203 0.98
88_D 108_T 1.201 0.98
287_Y 319_L 1.201 0.98
98_N 152_T 1.195 0.98
209_I 218_I 1.189 0.98
47_A 94_A 1.183 0.98
123_V 126_R 1.181 0.98
159_G 165_V 1.18 0.98
218_I 221_R 1.175 0.98
58_A 94_A 1.166 0.97
139_R 159_G 1.162 0.97
183_T 187_S 1.157 0.97
306_V 309_T 1.155 0.97
149_D 153_N 1.153 0.97
239_D 279_F 1.152 0.97
244_R 266_L 1.151 0.97
249_D 254_E 1.146 0.97
194_S 238_L 1.145 0.97
192_L 213_T 1.145 0.97
257_V 269_V 1.144 0.97
285_E 298_V 1.138 0.97
225_L 249_D 1.137 0.97
332_V 336_S 1.134 0.97
44_Y 60_S 1.13 0.97
106_G 116_I 1.123 0.97
265_I 268_K 1.115 0.96
194_S 242_R 1.101 0.96
176_L 179_A 1.1 0.96
54_A 82_T 1.099 0.96
255_V 277_V 1.097 0.96
150_D 192_L 1.092 0.96
55_L 329_Y 1.089 0.96
193_D 238_L 1.081 0.95
47_A 320_A 1.075 0.95
274_S 288_V 1.075 0.95
203_N 209_I 1.071 0.95
92_F 109_V 1.069 0.95
146_L 157_I 1.068 0.95
178_T 216_N 1.065 0.95
49_S 53_N 1.059 0.95
272_P 290_H 1.057 0.95
277_V 286_A 1.05 0.94
295_K 309_T 1.047 0.94
245_A 260_T 1.045 0.94
57_L 337_T 1.045 0.94
88_D 114_T 1.038 0.94
117_D 124_K 1.035 0.94
70_V 84_A 1.031 0.94
165_V 179_A 1.031 0.94
198_R 219_L 1.025 0.93
235_N 276_A 1.022 0.93
55_L 76_P 1.021 0.93
46_M 57_L 1.021 0.93
289_T 316_P 1.019 0.93
322_S 326_K 1.009 0.93
207_E 221_R 1.007 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vyhC100.89521000.253Contact Map0.913
4j87A10.81021000.294Contact Map0.806
3sfzA10.92351000.298Contact Map0.715
1gotB10.8811000.302Contact Map0.855
3ow8A40.87251000.304Contact Map0.873
4j73A10.81871000.305Contact Map0.843
3iz6a10.91221000.307Contact Map0.686
1erjA30.8981000.318Contact Map0.887
4e54B10.91221000.329Contact Map0.676
4bzjA20.92351000.33Contact Map0.683
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.4162 seconds.