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OPENSEQ.org
YDCO - Inner membrane protein YdcO
UniProt: P76103 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13758
Length: 391 (383)
Sequences: 421
Seq/Len: 1.10
YDCO
Paralog alert: 0.13 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
99_V 215_A 3.105 1.00
123_S 345_E 2.756 1.00
355_V 374_A 2.754 1.00
63_L 292_A 2.709 1.00
91_N 205_D 2.574 1.00
157_V 176_I 2.482 0.99
351_V 378_C 2.447 0.99
57_S 71_T 2.438 0.99
99_V 211_S 2.385 0.99
59_L 292_A 2.367 0.99
107_C 219_F 2.206 0.98
356_T 371_G 1.886 0.94
25_S 50_L 1.836 0.93
351_V 374_A 1.785 0.92
358_S 367_S 1.741 0.90
53_A 257_F 1.641 0.87
63_L 66_R 1.631 0.86
175_I 320_I 1.617 0.86
235_K 240_S 1.601 0.85
209_A 360_L 1.592 0.84
90_L 202_I 1.585 0.84
152_G 156_L 1.582 0.84
10_T 281_H 1.548 0.82
38_A 263_Y 1.523 0.81
15_F 297_F 1.517 0.80
7_P 10_T 1.514 0.80
5_S 288_W 1.504 0.79
278_P 282_P 1.503 0.79
199_P 302_G 1.487 0.78
80_L 221_V 1.476 0.78
135_R 139_Q 1.471 0.77
51_G 263_Y 1.469 0.77
63_L 291_A 1.46 0.77
92_E 205_D 1.448 0.76
33_A 136_F 1.429 0.74
161_T 165_A 1.425 0.74
67_V 241_A 1.419 0.74
206_F 260_F 1.393 0.72
8_P 279_E 1.386 0.71
60_T 63_L 1.37 0.70
50_L 331_T 1.369 0.70
256_V 373_I 1.367 0.70
20_I 222_T 1.362 0.69
220_L 288_W 1.359 0.69
59_L 295_G 1.348 0.68
61_L 249_F 1.346 0.68
137_G 354_L 1.321 0.66
24_S 50_L 1.318 0.66
181_V 319_W 1.318 0.66
36_A 85_L 1.312 0.65
41_A 200_T 1.281 0.62
16_L 224_A 1.273 0.62
22_Y 132_I 1.267 0.61
22_Y 379_Y 1.263 0.61
108_G 251_G 1.262 0.61
70_L 291_A 1.261 0.60
137_G 332_I 1.259 0.60
159_L 340_L 1.255 0.60
170_V 173_A 1.253 0.60
138_L 303_L 1.249 0.59
7_P 288_W 1.249 0.59
296_I 300_L 1.245 0.59
162_K 340_L 1.245 0.59
25_S 54_M 1.24 0.59
286_Q 289_L 1.24 0.59
211_S 215_A 1.24 0.59
101_N 254_A 1.239 0.58
105_V 251_G 1.237 0.58
223_M 227_N 1.236 0.58
75_T 78_A 1.235 0.58
151_C 322_M 1.231 0.58
124_L 158_W 1.219 0.57
92_E 207_S 1.219 0.57
21_G 54_M 1.216 0.56
98_I 310_G 1.211 0.56
211_S 302_G 1.209 0.56
38_A 222_T 1.203 0.55
47_M 276_Q 1.188 0.54
237_A 276_Q 1.181 0.53
21_G 25_S 1.178 0.53
29_I 222_T 1.178 0.53
33_A 46_W 1.176 0.53
174_M 356_T 1.165 0.52
199_P 207_S 1.163 0.51
111_G 137_G 1.161 0.51
49_A 69_V 1.161 0.51
15_F 19_L 1.16 0.51
250_T 366_G 1.16 0.51
80_L 128_M 1.159 0.51
28_I 138_L 1.15 0.50
75_T 250_T 1.138 0.49
75_T 129_L 1.138 0.49
21_G 50_L 1.136 0.49
165_A 172_A 1.134 0.49
161_T 172_A 1.133 0.48
124_L 216_L 1.126 0.48
107_C 223_M 1.125 0.48
210_H 215_A 1.121 0.47
51_G 331_T 1.12 0.47
274_I 336_L 1.119 0.47
18_V 222_T 1.118 0.47
64_W 233_A 1.111 0.46
220_L 300_L 1.11 0.46
286_Q 352_A 1.108 0.46
222_T 264_S 1.107 0.46
31_Q 141_F 1.106 0.46
332_I 350_V 1.106 0.46
175_I 344_R 1.106 0.46
28_I 263_Y 1.104 0.46
153_S 180_I 1.102 0.46
75_T 270_I 1.1 0.45
166_P 366_G 1.1 0.45
82_V 132_I 1.099 0.45
115_R 124_L 1.097 0.45
78_A 227_N 1.093 0.45
40_T 367_S 1.093 0.45
156_L 311_M 1.091 0.44
241_A 362_L 1.089 0.44
28_I 66_R 1.088 0.44
129_L 270_I 1.085 0.44
106_L 109_I 1.083 0.44
14_G 23_A 1.082 0.44
48_T 199_P 1.08 0.43
70_L 276_Q 1.08 0.43
160_A 165_A 1.079 0.43
23_A 237_A 1.078 0.43
202_I 303_L 1.078 0.43
100_T 361_T 1.078 0.43
115_R 175_I 1.076 0.43
38_A 85_L 1.076 0.43
369_F 373_I 1.073 0.43
211_S 330_S 1.07 0.43
156_L 255_L 1.069 0.42
101_N 105_V 1.069 0.42
57_S 253_L 1.066 0.42
207_S 210_H 1.065 0.42
32_A 46_W 1.065 0.42
270_I 347_D 1.064 0.42
71_T 250_T 1.055 0.41
21_G 97_F 1.053 0.41
255_L 326_L 1.053 0.41
267_I 319_W 1.052 0.41
129_L 259_P 1.051 0.41
84_G 128_M 1.049 0.41
24_S 321_Q 1.049 0.41
38_A 90_L 1.047 0.40
37_G 376_G 1.047 0.40
18_V 71_T 1.046 0.40
348_A 363_V 1.045 0.40
98_I 296_I 1.045 0.40
120_I 170_V 1.043 0.40
101_N 255_L 1.041 0.40
72_A 298_Y 1.04 0.40
24_S 54_M 1.038 0.40
56_V 341_H 1.038 0.40
66_R 117_M 1.036 0.39
84_G 97_F 1.036 0.39
70_L 294_A 1.034 0.39
90_L 254_A 1.032 0.39
22_Y 51_G 1.032 0.39
38_A 223_M 1.03 0.39
136_F 140_A 1.03 0.39
340_L 350_V 1.03 0.39
88_L 214_V 1.029 0.39
21_G 225_S 1.027 0.39
84_G 214_V 1.026 0.38
221_V 272_A 1.026 0.38
63_L 216_L 1.025 0.38
84_G 279_E 1.023 0.38
56_V 115_R 1.02 0.38
48_T 320_I 1.019 0.38
78_A 222_T 1.015 0.38
21_G 38_A 1.012 0.37
212_L 215_A 1.01 0.37
183_A 365_I 1.009 0.37
21_G 24_S 1.007 0.37
89_T 318_S 1.005 0.37
231_I 243_V 1.005 0.37
59_L 203_T 1.004 0.37
280_A 290_A 1.004 0.37
50_L 54_M 1.004 0.37
159_L 242_P 1.003 0.36
29_I 266_G 1 0.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qe7A10.94881000.799Contact Map0.34
2cfqA10.905425.80.978Contact Map0.068
4humA10.485918.60.979Contact Map0.098
3mktA20.480815.70.98Contact Map0.142
2nq2A20.345310.90.981Contact Map0
2kluA10.104910.70.981Contact Map0
3w4tA10.496290.982Contact Map0.181
4lz6A10.4917.70.982Contact Map0.119
2onkC40.276270.983Contact Map0.099
3bz1y10.09725.70.983Contact Map0.076
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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