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OPENSEQ.org
INSH5 - Transposase InsH for insertion sequence element IS5Y
UniProt: P76071 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:
Length: 326 (318)
Sequences: 1142
Seq/Len: 3.59
INSH5
Paralog alert: 0.49 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: INH10 INH11 INSH1 INSH2 INSH3 INSH4 INSH5 INSH6 INSH7 INSH8 INSH9
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
254_N 260_T 3.778 1.00
183_V 275_V 2.987 1.00
75_G 102_R 2.741 1.00
80_A 84_I 2.635 1.00
180_H 196_T 2.549 1.00
193_L 304_A 2.51 1.00
63_I 81_L 2.467 1.00
190_T 307_F 2.427 1.00
58_E 62_R 2.343 1.00
230_E 234_E 2.227 1.00
67_Q 77_M 2.067 1.00
81_L 91_A 1.983 1.00
232_L 237_V 1.978 1.00
40_V 120_Q 1.896 1.00
295_G 298_K 1.867 1.00
46_P 50_N 1.859 1.00
196_T 205_Q 1.849 0.99
103_T 106_M 1.833 0.99
124_T 127_R 1.815 0.99
83_E 86_S 1.801 0.99
192_S 212_G 1.778 0.99
293_Y 298_K 1.763 0.99
167_T 178_K 1.744 0.99
282_I 306_L 1.649 0.99
38_T 56_P 1.649 0.99
103_T 107_N 1.628 0.98
140_T 182_G 1.621 0.98
232_L 241_I 1.599 0.98
219_A 241_I 1.589 0.98
74_D 109_R 1.582 0.98
145_T 283_K 1.57 0.98
144_A 178_K 1.558 0.98
193_L 307_F 1.549 0.98
148_E 290_K 1.536 0.97
183_V 278_P 1.535 0.97
265_E 268_K 1.501 0.97
76_A 80_A 1.497 0.97
179_A 303_L 1.496 0.97
11_E 15_K 1.491 0.97
12_F 15_K 1.474 0.97
279_F 283_K 1.471 0.96
63_I 105_I 1.438 0.96
257_K 260_T 1.414 0.95
164_M 177_M 1.406 0.95
6_T 9_D 1.397 0.95
161_D 164_M 1.385 0.95
225_G 228_Q 1.38 0.94
189_L 314_R 1.374 0.94
66_M 70_Y 1.372 0.94
177_M 296_L 1.356 0.94
4_Q 7_F 1.345 0.93
7_F 15_K 1.334 0.93
216_F 240_L 1.325 0.93
38_T 58_E 1.324 0.93
55_Y 97_S 1.315 0.92
255_P 260_T 1.312 0.92
310_A 314_R 1.309 0.92
171_N 174_H 1.301 0.92
90_F 175_F 1.297 0.92
140_T 191_H 1.292 0.91
125_I 129_L 1.285 0.91
184_D 187_S 1.28 0.91
182_G 192_S 1.277 0.91
220_D 223_Y 1.262 0.90
127_R 131_E 1.255 0.90
314_R 317_Q 1.253 0.90
119_R 123_K 1.249 0.90
200_E 205_Q 1.247 0.89
167_T 198_A 1.234 0.89
7_F 12_F 1.232 0.89
102_R 106_M 1.229 0.89
181_I 279_F 1.228 0.88
93_L 97_S 1.227 0.88
192_S 209_L 1.227 0.88
60_M 108_F 1.221 0.88
45_Y 111_L 1.22 0.88
256_R 260_T 1.216 0.88
59_T 93_L 1.211 0.88
207_G 231_E 1.21 0.87
78_E 101_D 1.208 0.87
251_L 261_A 1.207 0.87
206_L 228_Q 1.201 0.87
29_E 62_R 1.2 0.87
284_R 289_V 1.187 0.86
121_L 308_T 1.176 0.85
309_L 313_F 1.173 0.85
180_H 209_L 1.172 0.85
88_R 99_L 1.171 0.85
68_H 302_Q 1.17 0.85
67_Q 80_A 1.167 0.85
211_H 235_V 1.164 0.85
142_V 182_G 1.163 0.85
291_A 302_Q 1.159 0.84
26_S 89_L 1.158 0.84
291_A 299_N 1.157 0.84
11_E 14_T 1.152 0.84
29_E 92_R 1.152 0.84
306_L 309_L 1.151 0.84
189_L 315_V 1.149 0.84
211_H 231_E 1.147 0.83
6_T 15_K 1.145 0.83
78_E 105_I 1.142 0.83
24_F 28_M 1.134 0.82
122_F 307_F 1.133 0.82
195_T 300_D 1.129 0.82
274_R 277_H 1.124 0.82
254_N 261_A 1.118 0.81
180_H 223_Y 1.115 0.81
12_F 16_R 1.114 0.81
181_I 278_P 1.111 0.81
148_E 174_H 1.105 0.80
282_I 310_A 1.105 0.80
255_P 258_N 1.103 0.80
138_Q 215_Q 1.1 0.80
33_P 36_N 1.099 0.80
15_K 18_Q 1.097 0.79
11_E 16_R 1.096 0.79
5_L 9_D 1.092 0.79
66_M 87_M 1.088 0.79
25_L 90_F 1.085 0.78
62_R 91_A 1.076 0.78
222_G 225_G 1.075 0.78
196_T 209_L 1.074 0.77
10_S 14_T 1.073 0.77
5_L 8_A 1.072 0.77
129_L 315_V 1.071 0.77
141_L 185_A 1.067 0.77
36_N 124_T 1.061 0.76
194_V 300_D 1.059 0.76
224_Q 244_R 1.058 0.76
60_M 219_A 1.058 0.76
142_V 206_L 1.053 0.75
288_F 306_L 1.052 0.75
293_Y 302_Q 1.047 0.75
281_I 310_A 1.045 0.75
144_A 180_H 1.045 0.75
74_D 108_F 1.045 0.75
144_A 166_Q 1.045 0.75
80_A 87_M 1.039 0.74
63_I 77_M 1.039 0.74
7_F 10_S 1.036 0.74
101_D 109_R 1.035 0.74
78_E 102_R 1.032 0.73
74_D 106_M 1.031 0.73
7_F 11_E 1.028 0.73
35_Q 38_T 1.028 0.73
63_I 100_P 1.027 0.73
311_N 314_R 1.024 0.73
169_K 176_G 1.021 0.72
10_S 18_Q 1.018 0.72
165_H 197_A 1.016 0.72
166_Q 175_F 1.016 0.72
146_I 167_T 1.014 0.72
8_A 12_F 1.013 0.71
254_N 258_N 1.013 0.71
60_M 104_T 1.012 0.71
307_F 310_A 1.01 0.71
167_T 180_H 1.006 0.71
286_F 313_F 1.002 0.70
293_Y 299_N 1.001 0.70
170_G 222_G 1.001 0.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1musA10.812996.90.915Contact Map0.508
3hotA20.8221530.956Contact Map0.62
1bcoA10.515338.40.96Contact Map0.406
3kksA20.414129.70.962Contact Map0.665
1c6vA40.435628.40.962Contact Map0.629
4dyqA20.404928.20.962Contact Map0.481
4fw1A20.4632270.963Contact Map0.593
1jkoC10.1564240.964Contact Map0.612
3l3uA20.435619.80.965Contact Map0.678
1ex4A20.429413.60.967Contact Map0.538
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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