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OPENSEQ.org
SMRA - Probable DNA endonuclease SmrA
UniProt: P76053 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13354
Length: 187 (185)
Sequences: 573
Seq/Len: 3.10
SMRA
Paralog alert: 0.53 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: SMRA YFCN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
102_V 119_I 3.546 1.00
109_A 117_V 2.407 1.00
158_H 165_Y 2.292 1.00
86_A 105_F 2.286 1.00
73_V 82_Y 2.129 1.00
13_M 16_V 2.041 1.00
123_K 162_G 1.983 1.00
139_A 143_T 1.982 1.00
117_V 166_V 1.739 0.99
109_A 114_L 1.657 0.98
124_G 134_V 1.65 0.98
120_I 162_G 1.613 0.98
4_D 7_S 1.546 0.97
135_R 153_T 1.545 0.97
106_I 117_V 1.536 0.97
4_D 8_L 1.536 0.97
155_L 165_Y 1.519 0.96
20_K 148_V 1.508 0.96
86_A 114_L 1.504 0.96
65_R 74_L 1.471 0.95
69_L 149_Q 1.462 0.95
156_P 162_G 1.43 0.94
125_R 135_R 1.406 0.94
9_F 13_M 1.403 0.94
182_H 185_R 1.403 0.94
153_T 161_S 1.374 0.93
174_A 177_E 1.338 0.91
76_K 82_Y 1.336 0.91
39_I 42_L 1.335 0.91
143_T 153_T 1.318 0.90
62_L 139_A 1.314 0.90
132_N 135_R 1.308 0.90
76_K 85_Q 1.292 0.89
152_C 158_H 1.263 0.88
17_Q 110_L 1.261 0.88
150_A 167_A 1.253 0.87
99_R 144_E 1.249 0.87
121_H 151_Y 1.239 0.86
7_S 11_D 1.23 0.86
105_F 117_V 1.229 0.86
105_F 162_G 1.221 0.85
121_H 147_D 1.22 0.85
178_N 181_R 1.208 0.84
91_L 98_C 1.203 0.84
139_A 153_T 1.192 0.83
33_Q 37_Q 1.183 0.83
86_A 109_A 1.182 0.83
72_G 115_R 1.175 0.82
96_E 119_I 1.172 0.82
118_L 165_Y 1.168 0.82
31_R 34_R 1.147 0.80
70_Q 73_V 1.146 0.80
68_G 73_V 1.146 0.80
15_D 18_P 1.138 0.79
110_L 169_R 1.128 0.78
69_L 148_V 1.125 0.78
70_Q 153_T 1.12 0.78
84_Q 155_L 1.116 0.77
110_L 147_D 1.115 0.77
165_Y 170_K 1.114 0.77
39_I 44_L 1.112 0.77
93_Q 101_M 1.112 0.77
148_V 166_V 1.104 0.76
40_D 45_D 1.099 0.76
40_D 44_L 1.097 0.76
73_V 76_K 1.096 0.76
98_C 134_V 1.091 0.75
5_D 8_L 1.085 0.75
64_F 70_Q 1.08 0.74
35_A 39_I 1.07 0.73
142_L 148_V 1.069 0.73
86_A 108_Q 1.068 0.73
86_A 117_V 1.067 0.73
76_K 115_R 1.066 0.73
108_Q 112_D 1.064 0.72
134_V 167_A 1.058 0.72
10_L 17_Q 1.053 0.71
117_V 168_L 1.051 0.71
49_T 52_F 1.05 0.71
90_L 105_F 1.049 0.71
82_Y 131_A 1.049 0.71
61_P 152_C 1.045 0.71
48_L 99_R 1.041 0.70
120_I 164_C 1.034 0.69
2_N 32_N 1.015 0.67
3_L 40_D 1.012 0.67
154_A 160_G 1.005 0.66
70_Q 121_H 1.003 0.66
75_D 135_R 1.001 0.66
102_V 148_V 1 0.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qd7X10.73261000.37Contact Map0.48
2zqeA10.443999.90.564Contact Map0.576
2d9iA10.486699.90.625Contact Map0.388
3fauA40.411899.90.643Contact Map0.556
2vkcA10.695299.80.649Contact Map0.445
1so7A10.33165.30.962Contact Map0.004
4e1pA20.32623.80.964Contact Map0.203
3ke2A30.59363.10.966Contact Map0.051
3hl2A40.310230.966Contact Map0.784
4hr6A10.21932.70.967Contact Map0.204
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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