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YCJR - Uncharacterized protein YcjR
UniProt: P76044 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13915
Length: 262 (259)
Sequences: 5911
Seq/Len: 22.82

YCJR
Paralog alert: 0.70 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: END4 FRLC HYI SGBU ULAE YCJR YGBM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
220_D 223_A 3.313 1.00
45_K 49_K 3.195 1.00
208_D 215_G 3.159 1.00
175_Q 202_G 3.083 1.00
86_E 139_T 2.96 1.00
82_E 135_V 2.915 1.00
126_S 168_E 2.795 1.00
20_R 51_T 2.794 1.00
29_G 236_Y 2.759 1.00
86_E 135_V 2.747 1.00
46_A 50_E 2.546 1.00
164_R 168_E 2.315 1.00
142_V 175_Q 2.253 1.00
75_L 79_K 2.239 1.00
195_H 227_Q 2.126 1.00
16_L 47_A 2.112 1.00
134_Q 171_L 2.092 1.00
14_N 17_E 2.069 1.00
20_R 24_E 2.059 1.00
253_R 257_A 2.01 1.00
47_A 51_T 2.007 1.00
189_N 192_Q 2.002 1.00
142_V 202_G 1.993 1.00
89_A 139_T 1.947 1.00
78_L 131_V 1.918 1.00
144_Y 202_G 1.904 1.00
122_R 164_R 1.859 1.00
95_G 144_Y 1.839 1.00
195_H 230_A 1.82 1.00
133_E 174_V 1.787 1.00
123_K 168_E 1.785 1.00
48_I 55_V 1.778 1.00
74_R 128_S 1.748 1.00
120_G 123_K 1.744 1.00
47_A 50_E 1.743 1.00
88_L 93_G 1.743 1.00
135_V 139_T 1.65 1.00
122_R 168_E 1.644 1.00
256_L 260_R 1.64 1.00
227_Q 230_A 1.627 1.00
204_V 228_L 1.625 1.00
163_R 167_V 1.624 1.00
23_K 51_T 1.61 1.00
85_L 136_A 1.601 1.00
83_R 86_E 1.586 1.00
124_M 127_D 1.573 1.00
79_K 83_R 1.57 1.00
226_E 230_A 1.566 1.00
208_D 217_G 1.561 1.00
85_L 139_T 1.559 1.00
16_L 43_E 1.516 1.00
43_E 46_A 1.513 1.00
2_K 54_P 1.5 1.00
42_E 90_E 1.495 1.00
16_L 50_E 1.491 1.00
20_R 47_A 1.491 1.00
40_N 43_E 1.488 1.00
134_Q 138_R 1.479 1.00
41_I 90_E 1.452 1.00
126_S 130_R 1.447 1.00
147_P 183_M 1.447 1.00
137_A 173_H 1.445 1.00
144_Y 177_I 1.425 1.00
19_F 51_T 1.415 1.00
160_A 196_D 1.398 0.99
167_V 200_L 1.386 0.99
133_E 169_N 1.383 0.99
135_V 138_R 1.381 0.99
137_A 171_L 1.371 0.99
78_L 82_E 1.367 0.99
175_Q 200_L 1.356 0.99
22_I 27_F 1.348 0.99
21_Y 24_E 1.344 0.99
27_F 239_Y 1.334 0.99
257_A 261_T 1.329 0.99
46_A 49_K 1.304 0.99
222_H 226_E 1.302 0.99
79_K 82_E 1.301 0.99
247_D 250_Q 1.295 0.99
216_S 254_D 1.294 0.99
130_R 170_D 1.285 0.99
48_I 53_L 1.274 0.99
95_G 142_V 1.271 0.99
42_E 46_A 1.265 0.99
192_Q 196_D 1.255 0.99
82_E 86_E 1.255 0.99
191_A 223_A 1.253 0.99
123_K 127_D 1.242 0.98
73_R 76_N 1.241 0.98
137_A 172_K 1.24 0.98
119_D 123_K 1.239 0.98
127_D 130_R 1.221 0.98
19_F 47_A 1.214 0.98
227_Q 231_D 1.212 0.98
194_L 227_Q 1.212 0.98
81_I 132_L 1.212 0.98
17_E 20_R 1.204 0.98
134_Q 137_A 1.203 0.98
117_S 120_G 1.201 0.98
126_S 169_N 1.195 0.98
43_E 47_A 1.194 0.98
192_Q 195_H 1.182 0.98
82_E 138_R 1.181 0.98
85_L 135_V 1.172 0.98
164_R 167_V 1.158 0.97
163_R 196_D 1.155 0.97
82_E 131_V 1.139 0.97
45_K 90_E 1.137 0.97
27_F 256_L 1.137 0.97
180_F 224_L 1.135 0.97
72_E 76_N 1.135 0.97
88_L 96_I 1.135 0.97
75_L 131_V 1.13 0.97
158_T 161_D 1.114 0.96
86_E 90_E 1.113 0.96
95_G 202_G 1.109 0.96
86_E 89_A 1.106 0.96
21_Y 249_A 1.102 0.96
71_E 75_L 1.102 0.96
162_A 176_I 1.102 0.96
54_P 94_K 1.101 0.96
22_I 30_F 1.093 0.96
178_G 183_M 1.077 0.95
74_R 127_D 1.072 0.95
119_D 164_R 1.071 0.95
23_K 52_G 1.07 0.95
41_I 91_V 1.069 0.95
85_L 141_T 1.061 0.95
223_A 227_Q 1.056 0.95
157_N 161_D 1.056 0.95
25_M 256_L 1.054 0.95
250_Q 254_D 1.047 0.94
136_A 143_V 1.043 0.94
130_R 171_L 1.033 0.94
163_R 197_N 1.031 0.94
131_V 134_Q 1.031 0.94
16_L 20_R 1.028 0.94
194_L 231_D 1.018 0.93
23_K 28_D 1.015 0.93
214_P 255_S 1.015 0.93
198_R 231_D 1.011 0.93
58_A 88_L 1.01 0.93
45_K 92_G 1.008 0.93
176_I 197_N 1.007 0.93
228_L 231_D 1.004 0.93
4_G 238_V 1.004 0.93
20_R 50_E 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kwsA20.97331000.158Contact Map0.68
3vylA80.96951000.171Contact Map0.722
2qulA40.98091000.174Contact Map0.75
3vniA40.97711000.175Contact Map0.767
2hk0A40.97711000.175Contact Map0.704
2qw5A20.96181000.182Contact Map0.617
1i60A10.95421000.184Contact Map0.67
1k77A10.93891000.197Contact Map0.687
3qc0A10.95421000.199Contact Map0.673
2zvrA20.95041000.202Contact Map0.766

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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