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DHAK - PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK
UniProt: P76015 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13901
Length: 356 (335)
Sequences: 1033
Seq/Len: 3.08
DHAK
Paralog alert: 0.28 [within 20: 0.08] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
169_S 172_A 3.584 1.00
174_A 178_R 3.182 1.00
128_T 174_A 3.096 1.00
128_T 171_D 2.969 1.00
90_A 101_L 2.918 1.00
232_D 299_R 2.639 1.00
163_A 168_D 2.611 1.00
160_V 173_C 2.601 1.00
280_A 300_L 2.589 1.00
277_R 340_L 2.567 1.00
178_R 182_N 2.559 1.00
209_N 227_P 2.554 1.00
166_R 341_A 2.511 1.00
236_D 299_R 2.407 1.00
296_V 328_F 2.347 1.00
313_R 344_D 2.314 1.00
126_K 171_D 2.26 1.00
23_H 294_Y 2.223 1.00
60_H 104_K 2.214 1.00
17_A 298_N 2.214 1.00
276_D 334_K 2.167 1.00
10_D 14_E 2.105 1.00
160_V 177_G 2.09 1.00
187_I 238_M 2.084 1.00
133_D 181_N 2.073 1.00
163_A 176_L 2.061 1.00
284_N 318_A 2.034 1.00
155_L 279_I 2 1.00
152_N 184_G 1.985 1.00
279_I 335_V 1.969 1.00
155_L 331_T 1.957 1.00
173_C 177_G 1.957 1.00
236_D 303_R 1.946 1.00
239_F 303_R 1.927 0.99
45_K 70_S 1.918 0.99
87_F 123_S 1.909 0.99
229_S 233_Q 1.884 0.99
279_I 343_W 1.883 0.99
162_A 342_L 1.844 0.99
232_D 298_N 1.843 0.99
180_L 333_L 1.84 0.99
66_Q 165_E 1.837 0.99
277_R 310_T 1.836 0.99
150_V 186_S 1.822 0.99
14_E 298_N 1.814 0.99
187_I 242_L 1.791 0.99
297_Y 314_N 1.783 0.99
240_D 244_V 1.78 0.99
179_K 336_D 1.752 0.99
37_R 165_E 1.742 0.99
230_S 233_Q 1.721 0.99
335_V 340_L 1.719 0.99
189_I 234_T 1.713 0.99
48_L 102_I 1.706 0.98
87_F 120_L 1.693 0.98
44_G 97_E 1.683 0.98
235_V 296_V 1.672 0.98
71_G 89_C 1.66 0.98
107_T 111_L 1.656 0.98
184_G 333_L 1.651 0.98
277_R 312_E 1.636 0.98
215_V 285_L 1.614 0.98
54_S 74_P 1.606 0.98
155_L 281_L 1.597 0.97
168_D 342_L 1.583 0.97
224_D 237_E 1.557 0.97
132_I 156_I 1.513 0.96
299_R 302_T 1.509 0.96
2_K 209_N 1.493 0.96
312_E 344_D 1.481 0.95
231_L 299_R 1.476 0.95
278_V 332_L 1.461 0.95
7_D 10_D 1.44 0.95
168_D 172_A 1.409 0.94
91_M 123_S 1.408 0.94
59_M 320_C 1.407 0.94
153_T 157_E 1.403 0.93
4_L 296_V 1.402 0.93
104_K 153_T 1.401 0.93
104_K 157_E 1.395 0.93
172_A 175_E 1.385 0.93
175_E 179_K 1.372 0.92
210_E 227_P 1.362 0.92
15_Q 291_S 1.353 0.92
35_V 64_I 1.343 0.91
50_S 69_L 1.325 0.91
280_A 332_L 1.313 0.90
49_L 93_V 1.312 0.90
60_H 153_T 1.302 0.90
160_V 180_L 1.299 0.89
160_V 176_L 1.299 0.89
166_R 345_A 1.298 0.89
279_I 333_L 1.297 0.89
4_L 234_T 1.296 0.89
87_F 91_M 1.283 0.89
40_A 95_G 1.278 0.88
22_A 297_Y 1.278 0.88
236_D 240_D 1.275 0.88
229_S 237_E 1.275 0.88
179_K 338_E 1.273 0.88
183_Q 334_K 1.267 0.88
21_K 298_N 1.264 0.88
90_A 120_L 1.26 0.87
45_K 165_E 1.251 0.87
207_A 210_E 1.25 0.87
107_T 145_A 1.245 0.87
99_V 125_V 1.244 0.87
282_V 300_L 1.241 0.86
151_A 281_L 1.237 0.86
101_L 117_T 1.23 0.86
73_C 86_I 1.23 0.86
185_H 245_N 1.227 0.86
130_V 174_A 1.22 0.85
110_I 131_V 1.208 0.84
166_R 342_L 1.207 0.84
36_T 92_Q 1.206 0.84
60_H 157_E 1.206 0.84
88_E 91_M 1.205 0.84
21_K 301_T 1.198 0.84
66_Q 348_H 1.187 0.83
213_F 238_M 1.181 0.82
235_V 328_F 1.181 0.82
155_L 333_L 1.174 0.82
210_E 225_R 1.172 0.82
195_T 324_D 1.168 0.81
5_I 295_G 1.163 0.81
103_I 129_T 1.16 0.81
318_A 321_T 1.158 0.81
173_C 176_L 1.156 0.81
68_M 349_T 1.148 0.80
6_N 14_E 1.146 0.80
49_L 71_G 1.144 0.80
301_T 305_Q 1.139 0.79
211_M 228_F 1.132 0.79
243_L 307_A 1.123 0.78
298_N 302_T 1.118 0.77
11_V 291_S 1.112 0.77
64_I 72_A 1.111 0.77
211_M 234_T 1.107 0.76
128_T 178_R 1.097 0.75
171_D 174_A 1.091 0.75
91_M 125_V 1.07 0.73
287_A 326_T 1.063 0.72
76_E 79_T 1.061 0.72
279_I 340_L 1.059 0.72
315_L 319_Y 1.056 0.71
282_V 330_I 1.052 0.71
153_T 217_I 1.05 0.71
17_A 302_T 1.047 0.71
60_H 217_I 1.042 0.70
60_H 103_I 1.034 0.69
104_K 217_I 1.029 0.69
240_D 303_R 1.028 0.69
312_E 340_L 1.023 0.68
68_M 161_G 1.019 0.68
2_K 210_E 1.017 0.67
299_R 303_R 1.013 0.67
236_D 306_Q 1.013 0.67
5_I 11_V 1.011 0.67
272_L 332_L 1.006 0.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1oi2A211000.007Contact Map0.775
3ct4A30.92131000.06Contact Map0.685
2iu4A20.92421000.063Contact Map0.771
1un8A20.91011000.09Contact Map0.658
3b48A60.365299.10.907Contact Map0.511
1mgpA10.747231.80.976Contact Map0.472
1u7zA30.533724.20.977Contact Map0.298
1xklA40.196622.50.978Contact Map0.154
3dqzA40.196621.70.978Contact Map0.145
2wflA10.210719.30.978Contact Map0.152
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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