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OPENSEQ.org
DHAL - PTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL
UniProt: P76014 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13900
Length: 210 (207)
Sequences: 1127
Seq/Len: 5.44
DHAL
Paralog alert: 0.22 [within 20: 0.04] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
127_D 175_R 3.581 1.00
190_Q 195_T 3.27 1.00
102_T 105_E 3.213 1.00
161_I 165_A 2.837 1.00
163_E 202_Q 2.682 1.00
167_Q 170_I 2.672 1.00
111_R 142_R 2.585 1.00
133_V 165_A 2.535 1.00
131_C 135_V 2.45 1.00
22_E 25_Y 2.391 1.00
114_A 131_C 2.154 1.00
114_A 138_V 2.095 1.00
166_A 198_M 2.086 1.00
160_S 164_S 1.952 1.00
87_F 113_G 1.935 1.00
38_H 196_S 1.908 1.00
159_S 205_A 1.864 1.00
135_V 139_E 1.861 1.00
90_R 116_G 1.792 1.00
125_P 135_V 1.732 1.00
173_Q 187_I 1.732 1.00
69_G 92_A 1.73 1.00
150_S 153_V 1.726 1.00
23_S 43_N 1.717 1.00
118_I 124_E 1.703 1.00
140_S 144_S 1.678 1.00
163_E 167_Q 1.671 1.00
164_S 168_S 1.628 0.99
15_C 200_M 1.579 0.99
17_D 21_T 1.576 0.99
20_S 43_N 1.51 0.99
159_S 198_M 1.493 0.99
95_T 109_M 1.468 0.99
182_L 185_R 1.457 0.98
111_R 115_D 1.433 0.98
60_D 63_F 1.43 0.98
137_V 165_A 1.423 0.98
168_S 172_M 1.421 0.98
114_A 135_V 1.419 0.98
9_V 13_T 1.41 0.98
133_V 161_I 1.407 0.98
4_S 7_Q 1.403 0.98
13_T 54_P 1.383 0.98
68_T 88_F 1.382 0.98
49_V 53_L 1.381 0.98
136_P 165_A 1.356 0.97
141_L 154_A 1.345 0.97
98_R 105_E 1.324 0.97
20_S 47_S 1.322 0.97
133_V 136_P 1.297 0.96
80_S 130_M 1.282 0.96
140_S 161_I 1.281 0.96
110_F 141_L 1.276 0.96
133_V 137_V 1.269 0.95
12_L 68_T 1.267 0.95
43_N 47_S 1.254 0.95
11_W 15_C 1.25 0.95
168_S 171_T 1.248 0.95
86_T 116_G 1.215 0.94
25_Y 28_G 1.215 0.94
22_E 199_F 1.207 0.94
87_F 91_A 1.195 0.93
139_E 143_Q 1.189 0.93
17_D 50_V 1.187 0.93
87_F 117_V 1.179 0.92
48_K 75_S 1.147 0.91
20_S 50_V 1.144 0.91
137_V 161_I 1.139 0.91
69_G 73_L 1.137 0.91
18_I 22_E 1.136 0.91
91_A 113_G 1.135 0.90
44_R 79_A 1.121 0.90
26_L 39_G 1.121 0.90
118_I 135_V 1.12 0.90
123_A 131_C 1.117 0.90
133_V 166_A 1.117 0.90
42_M 196_S 1.102 0.89
14_R 206_L 1.085 0.88
76_V 82_P 1.083 0.87
18_I 199_F 1.082 0.87
29_L 192_P 1.075 0.87
128_K 186_S 1.075 0.87
149_L 153_V 1.072 0.87
122_K 176_K 1.066 0.86
13_T 50_V 1.066 0.86
125_P 131_C 1.063 0.86
49_V 71_T 1.061 0.86
125_P 172_M 1.053 0.85
33_I 179_A 1.049 0.85
84_F 130_M 1.048 0.85
117_V 121_G 1.044 0.85
33_I 79_A 1.039 0.84
15_C 19_F 1.028 0.84
38_H 77_G 1.028 0.84
41_N 76_V 1.026 0.83
28_G 32_E 1.023 0.83
169_T 194_A 1.02 0.83
80_S 84_F 1.015 0.82
89_I 92_A 1.014 0.82
197_V 201_M 1.013 0.82
86_T 120_R 1.011 0.82
19_F 46_F 1.008 0.82
38_H 128_K 1.006 0.82
36_A 90_R 1.003 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3pnlB111000.125Contact Map0.674
1un8A20.94291000.184Contact Map0.599
3cr3A20.91431000.191Contact Map0.671
4htpA20.714327.60.949Contact Map0.059
3l2pA10.861918.60.953Contact Map0.045
1ashA10.566718.30.953Contact Map0.244
3jpzA20.62389.10.959Contact Map0.254
3l2fA180.62387.30.961Contact Map0.298
1qh4A40.633370.961Contact Map0.257
1x9fD30.54296.90.961Contact Map0.238
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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