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YCGE - HTH-type transcriptional repressor YcgE
UniProt: P75989 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13886
Length: 243 (234)
Sequences: 466
Seq/Len: 1.99

YCGE
Paralog alert: 0.51 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: MLRA YCGE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
167_L 178_L 3.011 1.00
4_Y 44_E 2.266 1.00
12_R 51_E 2.189 1.00
129_V 139_S 2.133 0.99
48_Q 51_E 2.108 0.99
22_A 25_R 1.875 0.98
6_I 32_P 1.69 0.96
56_W 112_P 1.662 0.95
92_L 100_L 1.658 0.95
15_I 19_T 1.626 0.95
108_G 149_Y 1.563 0.93
204_P 209_T 1.559 0.93
9_V 47_I 1.548 0.93
15_I 36_E 1.54 0.92
13_C 50_I 1.494 0.91
91_I 95_A 1.471 0.90
16_N 63_V 1.461 0.89
9_V 13_C 1.456 0.89
24_Q 32_P 1.417 0.88
6_I 24_Q 1.404 0.87
20_L 25_R 1.402 0.87
15_I 57_I 1.381 0.86
164_E 191_H 1.357 0.84
140_S 143_D 1.351 0.84
41_L 146_L 1.34 0.83
129_V 177_R 1.336 0.83
10_A 22_A 1.329 0.83
13_C 37_G 1.329 0.83
165_A 185_L 1.309 0.81
9_V 30_L 1.291 0.80
139_S 173_E 1.291 0.80
22_A 34_R 1.28 0.79
139_S 196_A 1.28 0.79
129_V 143_D 1.28 0.79
139_S 143_D 1.28 0.79
111_Y 120_V 1.27 0.78
129_V 196_A 1.27 0.78
66_V 70_L 1.266 0.78
53_I 56_W 1.249 0.77
24_Q 147_I 1.248 0.77
129_V 140_S 1.238 0.76
140_S 177_R 1.237 0.76
55_R 192_I 1.219 0.74
39_H 66_V 1.217 0.74
8_D 162_G 1.213 0.74
121_Y 178_L 1.211 0.74
158_R 163_K 1.208 0.73
36_E 120_V 1.206 0.73
56_W 70_L 1.202 0.73
6_I 18_V 1.196 0.72
50_I 158_R 1.19 0.72
24_Q 34_R 1.187 0.72
37_G 66_V 1.186 0.71
22_A 32_P 1.184 0.71
20_L 117_I 1.183 0.71
45_E 71_E 1.18 0.71
29_L 53_I 1.176 0.70
44_E 48_Q 1.172 0.70
53_I 66_V 1.171 0.70
10_A 17_P 1.165 0.69
42_F 150_A 1.164 0.69
8_D 111_Y 1.152 0.68
16_N 64_G 1.15 0.68
121_Y 226_E 1.148 0.68
195_L 199_I 1.143 0.67
5_S 66_V 1.141 0.67
102_A 197_D 1.138 0.67
173_E 196_A 1.136 0.67
16_N 19_T 1.13 0.66
165_A 190_W 1.129 0.66
13_C 16_N 1.128 0.66
225_N 228_L 1.128 0.66
22_A 41_L 1.126 0.66
6_I 21_R 1.125 0.66
53_I 70_L 1.118 0.65
6_I 38_G 1.113 0.64
230_H 234_Q 1.108 0.64
37_G 57_I 1.107 0.64
108_G 116_L 1.106 0.64
140_S 173_E 1.105 0.64
49_R 73_T 1.1 0.63
18_V 37_G 1.099 0.63
89_M 127_R 1.099 0.63
99_K 161_P 1.097 0.63
21_R 26_R 1.096 0.63
128_L 140_S 1.096 0.63
43_D 46_D 1.096 0.63
112_P 116_L 1.09 0.62
187_L 216_T 1.087 0.62
9_V 20_L 1.084 0.61
16_N 47_I 1.08 0.61
226_E 230_H 1.08 0.61
34_R 38_G 1.08 0.61
53_I 63_V 1.077 0.61
6_I 42_F 1.073 0.60
57_I 66_V 1.067 0.60
22_A 70_L 1.066 0.59
97_P 203_R 1.065 0.59
105_I 146_L 1.061 0.59
125_R 143_D 1.06 0.59
18_V 66_V 1.058 0.59
168_M 196_A 1.056 0.58
32_P 38_G 1.054 0.58
154_L 183_W 1.052 0.58
53_I 57_I 1.052 0.58
19_T 39_H 1.048 0.57
19_T 22_A 1.046 0.57
16_N 29_L 1.039 0.56
216_T 221_T 1.037 0.56
9_V 50_I 1.036 0.56
147_I 179_W 1.034 0.56
16_N 22_A 1.031 0.56
48_Q 156_E 1.031 0.56
15_I 58_S 1.028 0.55
7_G 18_V 1.025 0.55
17_P 25_R 1.018 0.54
37_G 41_L 1.016 0.54
97_P 141_M 1.015 0.54
45_E 166_I 1.014 0.54
30_L 203_R 1.01 0.53
62_P 100_L 1.01 0.53
125_R 129_V 1.009 0.53
113_V 170_W 1.009 0.53
18_V 22_A 1.005 0.53
32_P 41_L 1.003 0.52
6_I 53_I 1 0.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i2xB80.810799.80.702Contact Map0.345
3ezxA10.674999.80.704Contact Map0.292
1y80A10.666799.80.706Contact Map0.694
4hh0A20.971299.80.707Contact Map0.283
3bulA10.691499.70.709Contact Map0.281
4jgiA20.662699.70.715Contact Map0.285
4hh3C10.736699.70.724Contact Map0.396
3hh0A40.57299.60.74Contact Map0.42
3kp1A40.942499.60.741Contact Map0.204
2jmlA10.316999.60.741Contact Map0.261

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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