OPENSEQ.org - C56I - ECOLI GREMLIN

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C56I - Cytochrome b561 homolog 2

UniProt:	P75925	Sequence MSFTNTPERYGVISAAFHWLSAIIVYGMFALGLWMVTLSYYDGWYHKAPELHKSIGILLMMGLVIRVLWRVISPPPGPLPSYSPMTRLAARAGHLALYLLLFAIGISGYLISTADGKPISVFGWFDVPATLADAGAQADFAGALHFWLAWSVVVLSVMHGFMALKHHFIDKDDTLKRMLGKSSSDYGV	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG12659
Length:	188 (179)
Sequences:	1256
Seq/Len:	7.02

C56I
Paralog alert: 0.76 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: C561 C56H C56I

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
165_K	170_D	4.26	1.00
109_Y	113_T	3.272	1.00
164_L	168_F	3.266	1.00
25_V	101_L	2.926	1.00
21_S	63_L	2.857	1.00
14_S	69_W	2.553	1.00
95_L	99_L	2.536	1.00
167_H	174_T	2.478	1.00
54_S	122_F	2.244	1.00
21_S	101_L	2.205	1.00
83_S	86_T	2.173	1.00
93_G	158_M	2.071	1.00
21_S	62_G	2.033	1.00
13_I	69_W	1.975	1.00
63_L	101_L	1.948	1.00
11_G	14_S	1.929	1.00
88_L	91_R	1.888	1.00
11_G	69_W	1.837	1.00
167_H	175_L	1.767	1.00
11_G	73_S	1.749	1.00
32_G	35_M	1.739	1.00
16_A	20_L	1.732	1.00
14_S	73_S	1.66	1.00
167_H	176_K	1.635	1.00
53_K	112_S	1.512	0.99
60_M	109_Y	1.506	0.99
156_S	160_G	1.503	0.99
63_L	102_F	1.479	0.99
61_M	68_L	1.466	0.99
58_L	121_V	1.417	0.99
167_H	173_D	1.413	0.99
90_A	93_G	1.402	0.99
113_T	130_T	1.395	0.99
143_A	146_F	1.393	0.99
134_A	137_Q	1.375	0.99
137_Q	140_F	1.364	0.98
174_T	177_R	1.361	0.98
158_M	162_M	1.35	0.98
67_V	102_F	1.339	0.98
169_I	172_D	1.33	0.98
106_I	110_L	1.327	0.98
152_V	156_S	1.316	0.98
79_L	174_T	1.31	0.98
98_Y	101_L	1.276	0.97
70_R	75_P	1.273	0.97
93_G	162_M	1.271	0.97
5_N	11_G	1.257	0.97
162_M	172_D	1.244	0.97
69_W	73_S	1.226	0.96
103_A	148_L	1.22	0.96
92_A	95_L	1.218	0.96
110_L	141_A	1.203	0.96
173_D	176_K	1.2	0.96
17_F	65_I	1.195	0.96
84_P	88_L	1.194	0.96
29_F	156_S	1.186	0.95
150_W	154_V	1.155	0.94
10_Y	14_S	1.152	0.94
64_V	68_L	1.148	0.94
28_M	59_L	1.139	0.94
25_V	63_L	1.123	0.93
57_I	119_I	1.118	0.93
157_V	161_F	1.106	0.93
163_A	167_H	1.096	0.92
60_M	105_G	1.081	0.92
27_G	55_I	1.078	0.91
13_I	16_A	1.077	0.91
51_L	55_I	1.074	0.91
82_Y	174_T	1.074	0.91
88_L	92_A	1.073	0.91
99_L	161_F	1.071	0.91
119_I	127_V	1.063	0.91
84_P	87_R	1.058	0.90
107_S	149_A	1.055	0.90
175_L	179_L	1.054	0.90
32_G	49_P	1.043	0.89
101_L	105_G	1.043	0.89
154_V	158_M	1.036	0.89
92_A	96_A	1.012	0.88
67_V	95_L	1.011	0.87

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
4gd3A	2	0.9947	100	0.466	Contact Map	0.343
1kqfC	1	0.8989	99.9	0.511	Contact Map	0.516
1qleD	1	0.1915	8.4	0.952	Contact Map	0.418
1m56D	2	0.1915	7.5	0.953	Contact Map	0.539
3cx5C	2	0.6596	2.9	0.961	Contact Map	0.383
1pp9C	2	0.9255	2.7	0.962	Contact Map	0.34
1fftC	2	0.5691	2.5	0.963	Contact Map	0.117
2yevA	2	0.5532	2.3	0.963	Contact Map	0.225
4ev6A	5	0.3883	1.8	0.965	Contact Map	0.395
1v54C	2	0.5638	1.8	0.965	Contact Map	0.239

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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