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OPENSEQ.org
ELFC - Probable outer membrane usher protein ElfC
UniProt: P75857 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13711
Length: 866 (810)
Sequences: 1287
Seq/Len: 1.59
ELFC
Paralog alert: 0.75 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: ELFC FIMD HTRE SFMD YAGX YBGQ YEHB YFCU YHCD YQIG YRAJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
98_C 125_C 4.499 1.00
288_V 300_I 4.028 1.00
706_V 737_A 3.89 1.00
296_A 337_E 3.775 1.00
666_R 683_A 3.741 1.00
698_G 733_V 3.253 1.00
252_D 266_R 3.175 1.00
802_A 831_I 2.956 1.00
361_I 389_W 2.909 1.00
785_V 825_L 2.9 1.00
265_F 382_F 2.884 1.00
696_T 727_D 2.805 1.00
668_G 681_N 2.767 1.00
297_Q 336_K 2.725 1.00
293_K 341_S 2.682 1.00
829_G 847_Y 2.658 1.00
334_E 342_V 2.644 1.00
688_L 697_L 2.595 1.00
336_K 342_V 2.535 1.00
709_A 776_E 2.523 1.00
361_I 387_L 2.512 1.00
690_A 695_I 2.472 1.00
802_A 820_L 2.438 1.00
526_G 551_Y 2.415 1.00
691_H 696_T 2.397 1.00
218_S 230_W 2.365 1.00
293_K 343_N 2.363 1.00
800_A 833_V 2.326 1.00
181_F 201_L 2.308 1.00
301_K 306_T 2.297 0.99
638_S 655_S 2.284 0.99
332_L 344_S 2.281 0.99
335_I 343_N 2.234 0.99
433_S 479_T 2.227 0.99
553_T 560_L 2.221 0.99
789_T 845_I 2.169 0.99
707_L 731_Y 2.155 0.99
300_I 319_I 2.146 0.99
211_P 239_R 2.115 0.99
174_A 772_L 2.089 0.99
86_F 97_A 2.051 0.99
640_Q 653_S 2.043 0.99
73_V 145_R 2.042 0.99
529_Y 550_G 2.041 0.99
214_L 237_L 2.04 0.99
398_Y 427_D 2.013 0.98
70_V 86_F 1.997 0.98
206_G 215_R 1.994 0.98
70_V 139_F 1.98 0.98
427_D 447_R 1.978 0.98
687_S 698_G 1.976 0.98
693_Q 709_A 1.943 0.98
665_A 684_L 1.91 0.97
301_K 334_E 1.9 0.97
172_I 707_L 1.887 0.97
709_A 774_L 1.874 0.97
299_T 306_T 1.869 0.97
162_Y 165_P 1.866 0.97
705_N 772_L 1.862 0.97
214_L 235_S 1.845 0.97
687_S 701_L 1.844 0.97
598_Y 621_Q 1.825 0.96
260_F 400_G 1.821 0.96
445_S 467_R 1.778 0.96
691_H 731_Y 1.778 0.96
563_S 580_A 1.726 0.95
365_V 385_A 1.714 0.94
127_P 130_E 1.704 0.94
663_A 684_L 1.699 0.94
445_S 469_S 1.697 0.94
207_V 214_L 1.687 0.94
110_N 113_A 1.681 0.94
53_D 57_F 1.675 0.93
831_I 845_I 1.674 0.93
710_A 779_A 1.671 0.93
783_A 827_A 1.652 0.93
138_T 147_E 1.645 0.93
743_N 767_P 1.64 0.93
687_S 733_V 1.629 0.92
241_V 244_L 1.624 0.92
238_Q 247_E 1.622 0.92
149_S 313_S 1.62 0.92
802_A 833_V 1.607 0.92
72_I 84_V 1.606 0.91
789_T 820_L 1.603 0.91
269_Q 364_A 1.601 0.91
253_D 366_T 1.597 0.91
701_L 705_N 1.597 0.91
703_E 769_K 1.593 0.91
213_R 768_T 1.583 0.91
692_S 774_L 1.582 0.91
335_I 345_Y 1.582 0.91
299_T 336_K 1.581 0.91
288_V 331_L 1.574 0.90
275_N 769_K 1.569 0.90
445_S 538_W 1.56 0.90
444_Q 470_T 1.559 0.90
710_A 713_A 1.548 0.89
98_C 355_L 1.547 0.89
789_T 833_V 1.545 0.89
274_D 362_K 1.542 0.89
755_N 783_A 1.539 0.89
767_P 773_V 1.537 0.89
160_R 323_Y 1.537 0.89
249_T 271_A 1.533 0.89
253_D 265_F 1.526 0.88
347_V 355_L 1.526 0.88
552_N 561_G 1.523 0.88
177_L 205_S 1.521 0.88
292_A 312_V 1.515 0.88
289_R 318_E 1.512 0.88
687_S 705_N 1.506 0.88
796_L 833_V 1.506 0.88
706_V 745_I 1.496 0.87
125_C 355_L 1.483 0.86
688_L 695_I 1.477 0.86
716_T 726_T 1.476 0.86
660_G 663_A 1.473 0.86
285_A 357_R 1.472 0.86
459_T 468_Y 1.472 0.86
513_K 535_Q 1.469 0.86
395_T 416_F 1.456 0.85
597_S 624_G 1.452 0.85
176_L 705_N 1.451 0.85
430_Q 444_Q 1.451 0.85
67_V 83_N 1.449 0.85
69_R 83_N 1.443 0.84
100_T 103_S 1.441 0.84
332_L 346_S 1.441 0.84
208_N 215_R 1.439 0.84
797_R 800_A 1.436 0.84
170_E 242_I 1.425 0.83
791_K 796_L 1.422 0.83
353_P 382_F 1.407 0.82
274_D 360_R 1.398 0.82
409_A 429_T 1.386 0.81
530_L 549_F 1.382 0.81
240_A 247_E 1.379 0.81
173_N 207_V 1.375 0.80
522_L 526_G 1.374 0.80
240_A 768_T 1.371 0.80
265_F 366_T 1.368 0.80
713_A 779_A 1.363 0.79
137_V 148_I 1.36 0.79
566_Y 577_Q 1.359 0.79
175_L 207_V 1.357 0.79
527_S 820_L 1.357 0.79
73_V 78_I 1.353 0.79
65_P 651_N 1.352 0.79
742_E 764_N 1.349 0.78
279_D 741_R 1.348 0.78
216_N 235_S 1.34 0.78
689_V 772_L 1.338 0.78
689_V 707_L 1.332 0.77
261_D 475_T 1.324 0.77
181_F 199_Y 1.322 0.76
718_V 734_V 1.322 0.76
843_C 865_C 1.318 0.76
710_A 716_T 1.316 0.76
103_S 107_M 1.312 0.76
390_G 422_G 1.305 0.75
183_G 682_Y 1.304 0.75
295_N 337_E 1.304 0.75
461_F 517_N 1.3 0.75
413_G 422_G 1.3 0.75
216_N 232_N 1.297 0.75
402_Q 476_L 1.292 0.74
457_L 520_Q 1.292 0.74
693_Q 774_L 1.291 0.74
333_V 347_V 1.291 0.74
286_P 390_G 1.287 0.74
791_K 794_I 1.286 0.74
204_N 217_N 1.282 0.73
689_V 705_N 1.282 0.73
369_K 381_K 1.274 0.73
613_I 618_H 1.272 0.72
98_C 347_V 1.272 0.72
358_Q 393_W 1.27 0.72
173_N 772_L 1.267 0.72
732_T 735_P 1.266 0.72
845_I 863_A 1.263 0.72
785_V 849_L 1.262 0.72
350_S 355_L 1.261 0.72
782_G 824_G 1.258 0.71
691_H 694_G 1.258 0.71
758_L 761_A 1.251 0.71
516_V 530_L 1.246 0.70
391_G 786_L 1.246 0.70
179_Y 686_G 1.245 0.70
301_K 332_L 1.244 0.70
398_Y 413_G 1.241 0.70
266_R 371_R 1.238 0.70
789_T 796_L 1.238 0.70
249_T 253_D 1.238 0.70
299_T 309_Q 1.229 0.69
797_R 835_W 1.229 0.69
265_F 269_Q 1.227 0.69
787_M 861_M 1.227 0.69
173_N 692_S 1.225 0.68
696_T 729_R 1.222 0.68
459_T 520_Q 1.221 0.68
555_I 560_L 1.219 0.68
457_L 464_M 1.217 0.68
172_I 772_L 1.216 0.68
789_T 814_I 1.215 0.67
709_A 731_Y 1.214 0.67
534_Q 543_Q 1.21 0.67
140_N 147_E 1.208 0.67
358_Q 392_P 1.208 0.67
734_V 745_I 1.208 0.67
73_V 147_E 1.207 0.67
512_G 536_T 1.206 0.67
390_G 396_T 1.204 0.66
296_A 339_D 1.201 0.66
727_D 733_V 1.198 0.66
125_C 347_V 1.198 0.66
422_G 450_Y 1.195 0.66
297_Q 309_Q 1.193 0.65
241_V 270_L 1.192 0.65
711_P 726_T 1.191 0.65
660_G 665_A 1.19 0.65
708_I 833_V 1.185 0.65
800_A 835_W 1.181 0.64
170_E 211_P 1.179 0.64
427_D 445_S 1.177 0.64
74_L 155_I 1.177 0.64
511_R 538_W 1.176 0.64
104_L 109_V 1.174 0.64
614_D 617_G 1.174 0.64
71_D 74_L 1.172 0.63
172_I 692_S 1.17 0.63
180_S 718_V 1.169 0.63
690_A 707_L 1.168 0.63
726_T 784_R 1.166 0.63
787_M 822_M 1.163 0.63
139_F 144_L 1.161 0.62
445_S 466_Y 1.158 0.62
359_G 422_G 1.156 0.62
699_Q 723_G 1.154 0.62
830_T 844_H 1.153 0.62
240_A 347_V 1.146 0.61
240_A 343_N 1.145 0.61
353_P 451_A 1.141 0.60
71_D 81_T 1.134 0.60
711_P 729_R 1.133 0.60
457_L 532_G 1.133 0.60
768_T 771_A 1.128 0.59
805_D 809_A 1.127 0.59
534_Q 545_R 1.127 0.59
240_A 740_Y 1.125 0.59
784_R 823_A 1.125 0.59
239_R 248_L 1.124 0.59
696_T 707_L 1.121 0.58
250_V 268_V 1.118 0.58
462_Q 515_Q 1.117 0.58
150_V 300_I 1.114 0.58
335_I 347_V 1.112 0.57
319_I 735_P 1.109 0.57
120_L 131_I 1.108 0.57
398_Y 447_R 1.102 0.56
388_Q 784_R 1.1 0.56
132_I 135_A 1.1 0.56
836_G 839_P 1.1 0.56
236_Y 770_G 1.099 0.56
528_F 597_S 1.096 0.56
701_L 772_L 1.095 0.56
517_N 582_N 1.093 0.55
259_F 411_M 1.087 0.55
294_S 409_A 1.085 0.55
691_H 707_L 1.085 0.55
172_I 689_V 1.082 0.54
334_E 344_S 1.079 0.54
63_I 141_V 1.078 0.54
286_P 413_G 1.077 0.54
104_L 473_F 1.076 0.54
114_F 154_A 1.075 0.54
144_L 356_Q 1.069 0.53
317_F 337_E 1.068 0.53
464_M 516_V 1.068 0.53
157_S 320_S 1.064 0.52
629_L 637_Y 1.064 0.52
246_G 363_Y 1.061 0.52
98_C 704_T 1.06 0.52
286_P 422_G 1.06 0.52
105_D 156_K 1.059 0.52
428_A 528_F 1.059 0.52
232_N 252_D 1.058 0.52
149_S 314_P 1.057 0.52
246_G 272_S 1.055 0.51
611_T 619_T 1.055 0.51
130_E 300_I 1.055 0.51
67_V 85_N 1.055 0.51
522_L 551_Y 1.055 0.51
782_G 821_Y 1.051 0.51
272_S 277_L 1.049 0.51
696_T 731_Y 1.047 0.51
168_W 766_V 1.044 0.50
391_G 397_W 1.042 0.50
816_D 823_A 1.042 0.50
86_F 95_I 1.041 0.50
261_D 445_S 1.041 0.50
471_S 745_I 1.041 0.50
63_I 95_I 1.04 0.50
398_Y 798_F 1.038 0.50
205_S 216_N 1.034 0.49
109_V 132_I 1.033 0.49
132_I 154_A 1.033 0.49
398_Y 538_W 1.032 0.49
657_D 664_D 1.032 0.49
176_L 689_V 1.031 0.49
125_C 476_L 1.03 0.49
148_I 196_G 1.03 0.49
624_G 653_S 1.029 0.49
295_N 314_P 1.029 0.49
369_K 379_E 1.027 0.48
415_G 425_S 1.027 0.48
176_L 772_L 1.02 0.48
433_S 561_G 1.02 0.48
232_N 706_V 1.019 0.48
707_L 774_L 1.019 0.48
699_Q 724_L 1.016 0.47
281_L 284_F 1.016 0.47
447_R 824_G 1.015 0.47
167_R 402_Q 1.013 0.47
433_S 474_Y 1.01 0.47
314_P 617_G 1.008 0.47
598_Y 611_T 1.008 0.47
297_Q 311_Y 1.006 0.46
693_Q 697_L 1.003 0.46
426_F 446_Y 1.002 0.46
105_D 718_V 1.001 0.46
171_G 302_Q 1.001 0.46
429_T 445_S 1 0.46
263_V 402_Q 1 0.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rfzB20.941000.109Contact Map0.719
3fipA20.54971000.477Contact Map0.72
3fcgA20.10391000.842Contact Map0.776
4b0mA10.15361000.853Contact Map0.854
3bwuD10.14431000.868Contact Map0.866
2xetA20.098299.80.906Contact Map0.879
3l48A50.09799.70.914Contact Map0.951
4kdwA10.130558.50.981Contact Map0.482
3e8vA10.085538.20.983Contact Map0.428
3txaA10.084326.40.985Contact Map
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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