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OPENSEQ.org
YAIS - Uncharacterized deacetylase YaiS
UniProt: P71311 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13302
Length: 185 (165)
Sequences: 1650
Seq/Len: 10.00
YAIS
Paralog alert: 0.37 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
71_N 74_K 3.489 1.00
35_A 168_V 3.206 1.00
52_M 134_V 2.677 1.00
86_F 101_A 2.54 1.00
48_A 109_Q 2.534 1.00
39_R 43_K 2.526 1.00
42_Q 175_V 2.526 1.00
21_A 37_L 2.48 1.00
133_A 136_Q 2.355 1.00
18_G 46_Y 2.307 1.00
22_I 138_S 2.303 1.00
75_I 182_K 2.299 1.00
42_Q 172_Y 2.243 1.00
40_L 45_I 2.086 1.00
46_Y 79_H 2.023 1.00
39_R 172_Y 2.022 1.00
82_I 108_N 1.995 1.00
48_A 82_I 1.952 1.00
19_I 40_L 1.933 1.00
37_L 41_A 1.926 1.00
98_M 137_A 1.921 1.00
40_L 120_Y 1.852 1.00
20_L 50_V 1.842 1.00
178_A 181_K 1.824 1.00
50_V 105_I 1.788 1.00
21_A 29_I 1.747 1.00
121_T 138_S 1.668 1.00
38_A 76_L 1.632 1.00
20_L 106_I 1.59 1.00
22_I 50_V 1.557 1.00
54_T 66_H 1.553 1.00
50_V 102_L 1.542 1.00
71_N 182_K 1.531 1.00
175_V 178_A 1.523 1.00
48_A 80_Q 1.504 1.00
84_L 101_A 1.467 1.00
33_C 120_Y 1.455 1.00
75_I 178_A 1.437 1.00
119_V 142_C 1.405 0.99
66_H 70_R 1.384 0.99
67_E 71_N 1.382 0.99
82_I 105_I 1.379 0.99
101_A 104_D 1.378 0.99
38_A 175_V 1.372 0.99
36_S 166_E 1.369 0.99
37_L 47_I 1.322 0.99
103_E 107_K 1.307 0.99
51_V 69_S 1.297 0.99
65_R 88_D 1.296 0.99
18_G 112_S 1.285 0.99
76_L 179_A 1.283 0.99
30_E 72_A 1.275 0.99
105_I 109_Q 1.254 0.99
102_L 137_A 1.25 0.99
35_A 176_K 1.244 0.98
35_A 167_S 1.236 0.98
32_G 151_Y 1.233 0.98
34_G 76_L 1.229 0.98
24_A 122_M 1.227 0.98
36_S 40_L 1.226 0.98
39_R 170_E 1.225 0.98
64_D 185_S 1.197 0.98
67_E 70_R 1.192 0.98
38_A 179_A 1.172 0.98
27_D 128_H 1.153 0.97
99_I 140_V 1.147 0.97
66_H 83_H 1.142 0.97
23_G 29_I 1.124 0.97
54_T 85_N 1.121 0.97
20_L 109_Q 1.115 0.96
132_L 136_Q 1.112 0.96
58_G 88_D 1.107 0.96
37_L 76_L 1.088 0.96
72_A 179_A 1.068 0.95
49_A 73_L 1.063 0.95
75_I 175_V 1.057 0.95
34_G 179_A 1.042 0.94
41_A 47_I 1.036 0.94
45_I 120_Y 1.03 0.94
71_N 75_I 1.024 0.93
57_S 87_A 1.011 0.93
174_T 178_A 1.005 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ixdA20.87571000.278Contact Map0.8
1uanA20.86491000.284Contact Map0.7
3dffA10.91891000.327Contact Map0.691
3dfiA10.91891000.329Contact Map0.719
1q74A40.89731000.337Contact Map0.775
3ot5A40.875778.40.918Contact Map0.677
2x0dA20.848668.20.924Contact Map0.402
2r60A10.8541650.926Contact Map0.508
3ih5A40.794659.80.928Contact Map0.595
1vgvA40.783857.40.929Contact Map0.646
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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