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OPENSEQ.org

ULAB - Ascorbate-specific phosphotransferase enzyme IIB component
UniProt: P69822 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12494
Length: 101 (93)
Sequences: 653
Seq/Len: 7.02

ULAB
Paralog alert: 0.77 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: PTKB SGCB ULAB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
29_Q 85_G 4.351 1.00
23_V 55_I 3.082 1.00
40_A 43_E 2.556 1.00
30_S 89_L 2.312 1.00
20_K 24_D 2.203 1.00
83_D 87_K 2.118 1.00
86_P 90_E 2.005 1.00
4_R 35_T 1.937 1.00
85_G 89_L 1.899 1.00
82_A 86_P 1.681 1.00
27_L 34_H 1.575 1.00
7_A 23_V 1.505 0.99
39_C 43_E 1.503 0.99
19_M 75_V 1.477 0.99
26_F 30_S 1.447 0.99
87_K 90_E 1.388 0.99
6_L 39_C 1.37 0.98
89_L 93_K 1.344 0.98
19_M 57_S 1.285 0.97
82_A 85_G 1.27 0.97
11_N 41_V 1.252 0.97
56_A 60_I 1.223 0.96
31_N 89_L 1.191 0.96
84_F 88_L 1.175 0.95
83_D 86_P 1.171 0.95
5_I 27_L 1.168 0.95
26_F 85_G 1.158 0.95
17_M 38_S 1.152 0.94
30_S 86_P 1.129 0.94
80_S 83_D 1.125 0.93
73_V 91_V 1.118 0.93
17_M 57_S 1.106 0.93
91_V 94_E 1.095 0.92
20_K 36_V 1.084 0.92
14_G 21_M 1.082 0.92
77_N 88_L 1.082 0.92
90_E 93_K 1.078 0.91
27_L 33_D 1.075 0.91
6_L 54_I 1.071 0.91
59_H 78_M 1.059 0.90
13_Q 17_M 1.036 0.89
22_K 74_G 1.034 0.89
25_Q 81_P 1.032 0.89
22_K 84_F 1.024 0.88
51_A 54_I 1.021 0.88
11_N 24_D 1.008 0.87
24_D 28_T 1.004 0.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1tvmA10.90199.70.403Contact Map0.322
1e2bA10.960499.60.409Contact Map0.437
4mgeA20.970399.60.423Contact Map0.468
3czcA10.920899.60.424Contact Map0.673
2l2qA10.950599.50.45Contact Map0.341
1vkrA10.960499.50.458Contact Map0.46
3nbmA10.90199.50.459Contact Map0.406
2m1zA10.940699.40.485Contact Map0.317
2kyrA10.960499.40.501Contact Map0.512
3sqnA20.851598.80.61Contact Map0.389

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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