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OPENSEQ.org

RL25 - 50S ribosomal protein L25
UniProt: P68919 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10885
Length: 94 (93)
Sequences: 1317
Seq/Len: 14.16

RL25
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
5_N 64_V 3.313 1.00
43_D 46_K 2.897 1.00
25_K 41_E 2.838 1.00
20_L 41_E 2.702 1.00
30_I 40_I 2.271 1.00
62_T 69_E 2.094 1.00
47_V 89_I 2.058 1.00
7_E 25_K 2.018 1.00
30_I 63_I 1.886 1.00
30_I 72_V 1.81 1.00
4_I 9_R 1.761 1.00
25_K 43_D 1.657 1.00
29_I 39_A 1.639 1.00
64_V 69_E 1.61 1.00
60_V 94_A 1.6 1.00
15_G 18_R 1.552 1.00
13_G 17_S 1.505 1.00
62_T 71_K 1.484 1.00
70_I 93_R 1.432 1.00
7_E 66_D 1.401 0.99
28_A 40_I 1.399 0.99
11_E 19_R 1.369 0.99
8_V 66_D 1.366 0.99
28_A 89_I 1.358 0.99
49_N 52_A 1.328 0.99
6_A 9_R 1.326 0.99
33_G 93_R 1.3 0.99
3_T 62_T 1.275 0.99
44_H 48_M 1.27 0.99
75_Q 92_V 1.253 0.99
19_R 23_A 1.243 0.98
17_S 20_L 1.209 0.98
3_T 64_V 1.178 0.98
26_F 47_V 1.177 0.98
77_V 89_I 1.16 0.97
51_Q 86_L 1.148 0.97
28_A 47_V 1.105 0.96
6_A 65_V 1.103 0.96
30_I 70_I 1.098 0.96
7_E 41_E 1.089 0.96
9_R 21_R 1.087 0.96
44_H 85_K 1.03 0.94
48_M 52_A 1.017 0.93
8_V 68_K 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1b75A111000.03Contact Map0.706
1feuA20.946899.90.122Contact Map0.77
2zjrS10.904399.90.146Contact Map0.448
3s51A40.86176.70.916Contact Map0.133
2z7bA10.85114.70.921Contact Map0.21
1htwA30.80854.30.923Contact Map0.039
4j2nA50.55323.80.925Contact Map0.382
2r01A10.64893.80.925Contact Map0.196
2vvfA60.79793.70.926Contact Map0.16
1z4hA10.57453.50.926Contact Map0.248

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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