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OPENSEQ.org

GLRX1 - Glutaredoxin-1
UniProt: P68688 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10417
Length: 85 (76)
Sequences: 1668
Seq/Len: 21.95

GLRX1
Paralog alert: 0.62 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: GLRX1 GLRX3 NRDH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
72_Y 76_A 3.685 1.00
18_K 35_Y 2.474 1.00
24_L 79_V 2.139 1.00
22_E 33_Y 2.082 1.00
4_V 51_K 1.956 1.00
44_T 47_D 1.922 1.00
61_Q 68_H 1.858 1.00
17_A 62_I 1.844 1.00
19_D 23_K 1.786 1.00
16_R 72_Y 1.721 1.00
3_T 31_F 1.7 1.00
54_K 68_H 1.686 1.00
62_I 75_F 1.565 1.00
47_D 51_K 1.558 1.00
7_G 35_Y 1.549 1.00
2_Q 65_D 1.518 1.00
54_K 61_Q 1.503 1.00
77_A 81_E 1.499 1.00
9_S 37_D 1.498 1.00
20_L 79_V 1.379 0.99
5_I 21_A 1.343 0.99
49_Q 57_E 1.293 0.99
8_R 45_K 1.288 0.99
46_E 49_Q 1.285 0.99
13_Y 72_Y 1.263 0.99
20_L 72_Y 1.262 0.99
16_R 73_T 1.255 0.99
7_G 18_K 1.201 0.98
22_E 31_F 1.175 0.98
8_R 59_V 1.165 0.97
48_L 52_A 1.156 0.97
69_I 78_W 1.14 0.97
76_A 80_K 1.091 0.96
52_A 61_Q 1.087 0.96
6_F 66_Q 1.077 0.95
17_A 72_Y 1.06 0.95
37_D 42_G 1.055 0.95
16_R 76_A 1.051 0.94
34_Q 38_I 1.028 0.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jadA10.976599.80.22Contact Map0.695
1u6tA10.905999.80.275Contact Map0.545
2ct6A10.917699.70.317Contact Map0.418
2wciA20.917699.70.332Contact Map0.693
1t1vA20.941299.70.351Contact Map0.635
3l4nA10.941299.70.363Contact Map0.78
2x8gA10.941299.60.373Contact Map0.69
2wemA40.929499.60.373Contact Map0.649
3gx8A10.941299.60.375Contact Map0.568
3ctgA10.976599.60.38Contact Map0.709

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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