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OPENSEQ.org
DPAL - Putative diaminopropionate ammonia-lyase
UniProt: P66899 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13054
Length: 398 (343)
Sequences: 5270
Seq/Len: 15.36
DPAL
Paralog alert: 0.81 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: CYSK CYSM DPAL SDHD TDCB TRPB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
131_A 138_A 4.239 1.00
213_A 372_L 4.225 1.00
254_H 308_Q 3.879 1.00
174_L 177_Q 3.792 1.00
61_K 370_V 3.355 1.00
316_V 349_A 3.259 1.00
227_V 244_L 3.1 1.00
226_H 256_I 2.911 1.00
49_A 61_K 2.853 1.00
144_K 165_D 2.851 1.00
148_Q 152_D 2.824 1.00
177_Q 181_Q 2.819 1.00
261_D 313_Q 2.762 1.00
137_N 160_E 2.688 1.00
44_P 215_E 2.67 1.00
139_V 160_E 2.464 1.00
44_P 216_Q 2.439 1.00
87_Q 201_W 2.415 1.00
237_A 306_A 2.366 1.00
267_Y 271_V 2.324 1.00
264_D 268_R 2.298 1.00
89_L 92_K 2.293 1.00
241_L 305_C 2.22 1.00
313_Q 316_V 2.218 1.00
141_Y 178_H 2.163 1.00
139_V 162_I 2.142 1.00
47_L 372_L 2.138 1.00
192_W 238_G 2.126 1.00
227_V 240_V 2.121 1.00
245_V 307_T 2.041 1.00
49_A 63_L 1.994 1.00
207_A 211_D 1.992 1.00
210_A 240_V 1.937 1.00
49_A 54_A 1.912 1.00
51_D 55_N 1.86 1.00
240_V 374_I 1.832 1.00
56_L 323_V 1.83 1.00
225_T 369_A 1.829 1.00
289_L 342_V 1.782 1.00
155_L 160_E 1.78 1.00
222_V 370_V 1.773 1.00
45_T 70_R 1.727 1.00
272_K 276_V 1.715 1.00
224_P 372_L 1.696 1.00
213_A 240_V 1.696 1.00
277_N 293_E 1.684 1.00
84_A 194_G 1.677 1.00
366_N 369_A 1.656 1.00
63_L 370_V 1.639 1.00
237_A 302_L 1.636 1.00
256_I 308_Q 1.636 1.00
35_F 83_Y 1.631 1.00
323_V 348_A 1.629 1.00
228_L 347_L 1.578 1.00
47_L 217_M 1.544 1.00
85_I 134_L 1.542 1.00
26_Q 30_K 1.542 1.00
226_H 254_H 1.54 1.00
217_M 372_L 1.532 1.00
225_T 370_V 1.532 1.00
62_I 347_L 1.524 1.00
210_A 243_Y 1.507 1.00
258_V 346_V 1.505 1.00
193_E 296_P 1.502 1.00
64_V 324_L 1.501 1.00
343_G 373_V 1.492 1.00
124_G 154_I 1.475 1.00
315_S 319_L 1.472 1.00
310_I 346_V 1.472 1.00
152_D 155_L 1.449 1.00
321_M 380_T 1.443 1.00
41_G 82_A 1.44 1.00
27_S 30_K 1.425 1.00
185_E 198_I 1.423 1.00
240_V 255_S 1.421 1.00
142_M 154_I 1.409 1.00
57_F 348_A 1.402 0.99
52_D 55_N 1.398 0.99
172_V 176_M 1.398 0.99
340_G 376_T 1.391 0.99
286_M 317_A 1.388 0.99
203_M 301_I 1.379 0.99
267_Y 311_S 1.379 0.99
73_L 129_W 1.368 0.99
318_A 338_E 1.343 0.99
230_Q 376_T 1.341 0.99
139_V 184_W 1.335 0.99
270_G 309_F 1.332 0.99
324_L 344_L 1.328 0.99
142_M 163_V 1.319 0.99
336_S 375_S 1.313 0.99
262_K 314_D 1.313 0.99
226_H 371_V 1.31 0.99
264_D 267_Y 1.303 0.99
346_V 350_V 1.298 0.99
264_D 311_S 1.283 0.99
324_L 336_S 1.279 0.99
227_V 255_S 1.266 0.99
302_L 306_A 1.265 0.99
324_L 375_S 1.25 0.99
320_G 345_G 1.239 0.98
289_L 339_S 1.239 0.98
217_M 370_V 1.237 0.98
151_V 163_V 1.235 0.98
56_L 327_P 1.231 0.98
297_L 300_E 1.228 0.98
176_M 180_Q 1.223 0.98
53_L 344_L 1.221 0.98
228_L 258_V 1.221 0.98
211_D 243_Y 1.215 0.98
300_E 303_R 1.21 0.98
257_I 309_F 1.21 0.98
321_M 341_A 1.209 0.98
33_R 215_E 1.207 0.98
173_R 177_Q 1.2 0.98
174_L 178_H 1.199 0.98
268_R 271_V 1.195 0.98
226_H 369_A 1.191 0.98
61_K 368_D 1.19 0.98
188_Q 194_G 1.181 0.98
132_Q 138_A 1.166 0.97
194_G 201_W 1.164 0.97
90_C 110_G 1.161 0.97
141_Y 174_L 1.156 0.97
36_H 40_A 1.155 0.97
260_P 289_L 1.154 0.97
365_L 369_A 1.151 0.97
228_L 350_V 1.151 0.97
210_A 244_L 1.15 0.97
318_A 388_V 1.149 0.97
195_Y 201_W 1.148 0.97
63_L 217_M 1.142 0.97
248_Y 253_L 1.14 0.97
217_M 224_P 1.135 0.97
300_E 304_N 1.132 0.97
325_G 335_I 1.132 0.97
284_T 290_A 1.131 0.97
266_I 294_P 1.13 0.97
28_Q 31_L 1.128 0.97
209_L 374_I 1.115 0.96
215_E 219_E 1.111 0.96
203_M 242_G 1.097 0.96
52_D 327_P 1.096 0.96
254_H 369_A 1.095 0.96
224_P 253_L 1.089 0.96
250_P 253_L 1.081 0.95
82_A 86_A 1.08 0.95
268_R 272_K 1.072 0.95
273_G 303_R 1.071 0.95
46_P 69_K 1.07 0.95
209_L 236_M 1.07 0.95
231_A 237_A 1.068 0.95
231_A 309_F 1.063 0.95
151_V 155_L 1.063 0.95
149_E 382_V 1.06 0.95
117_T 140_I 1.057 0.95
67_E 376_T 1.056 0.95
352_Y 362_K 1.054 0.95
320_G 344_L 1.048 0.94
178_H 182_H 1.043 0.94
90_C 112_K 1.042 0.94
312_C 345_G 1.039 0.94
340_G 375_S 1.036 0.94
322_R 389_V 1.036 0.94
31_L 35_F 1.03 0.94
228_L 256_I 1.03 0.94
170_D 173_R 1.028 0.94
323_V 327_P 1.025 0.93
256_I 310_I 1.022 0.93
293_E 296_P 1.021 0.93
228_L 346_V 1.021 0.93
195_Y 297_L 1.015 0.93
296_P 300_E 1.012 0.93
301_I 305_C 1.01 0.93
265_C 269_S 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4d9iA20.98491000.267Contact Map0.76
1tdjA10.84671000.287Contact Map0.714
1v71A10.81161000.307Contact Map0.759
2gn0A40.84671000.31Contact Map0.852
3ss7X10.94221000.313Contact Map0.606
1ve5A40.78141000.325Contact Map0.778
3l6bA10.84171000.327Contact Map0.754
4h27A10.87691000.345Contact Map0.683
2rkbA50.79151000.348Contact Map0.713
3iauA20.85431000.369Contact Map0.776
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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